FedInvent™ Patent Applications
Application Details for Thursday, May 11, 2023
This page was updated on Thursday, May 11, 2023 at 09:02 AM GMT
Department of Health and Human Services (HHS)
| US 20230140976 | Muschler |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | John L. Muschler (Lake Oswego, Oregon) |
| ABSTRACT | The present disclosure relates to delivering payloads to the interior of a cell. In particular, the present disclosure provides three monoclonal antibodies that bind dystroglycan (DG) on the surface of cells. The antibodies are internalized into endocytic vesicles inside the cells once they are bound to DG. Thus, these antibodies can be used to selectively target and deliver payloads to cells, such as epithelial cells in cancer. The disclosed antibodies bind to DG independent of variable DG glycosylation. The targeted delivery enables selective treatment, imaging, and surveillance of cells in cancer, such as bladder cancer, along with other uses. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/907534 |
| CURRENT CPC | Peptides C07K 16/28 (20130101) Original (OR) Class C07K 2317/77 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141003 | Osman et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Iman Osman (Jersey City, New Jersey); Judy Zhong (New York, New York); Paul Johannet (Scarsdale, New York) |
| ABSTRACT | Provided are compositions and methods for determining baseline serum autoantibodies (autoAbs) for use in patient selection and for treatment with immune checkpoint blockade agents to promote avoidance of development of severe immune related adverse events (IRAEs). The treatments include administering anti-cancer agents that are not predicted to cause toxicity to selected patients, and administering agents to reduce predicted toxicity in selected patients. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 18/054043 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141413 | BIGNER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darell BIGNER (Mebane, North Carolina); Vidyalakshmi CHANDRAMOHAN (Durham, North Carolina); Ira H. PASTAN (Potomac, Maryland) |
| ABSTRACT | Provided is a combination and a method of using combination therapy to treat tumor in an individual. An immunotoxin and an immunostimulator are administered to the individual, wherein the immunotoxin comprises a single chain variable region antibody fused to a PE38 truncated Pseudomonas exotoxin, and the immunostimulator comprises an anti-CD40 agonist antibody. The combination may further comprise a checkpoint inhibitor comprising one or more of an anti-PD-1 antibody and an anti-PD-L1 antibody. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/773494 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6829 (20170801) Original (OR) Class A61K 47/6849 (20170801) A61K 47/6851 (20170801) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2863 (20130101) C07K 16/2878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141434 | YOON et al. |
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| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
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| INVENTOR(S) | Young-Sup YOON (Atlanta, Georgia); Sang Ho Lee (Atlanta, Georgia); Seongho BAE (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to using a ETV2 gene or gene products including DNA, RNA, mRNA, ETV2 proteins, or protein containing exosomes, to directly reprogram and convert resident non-endothelial cells of host into endothelial cells in situ, i.e., in places of the body or tissue where ETV2 is injected. In certain embodiments, it is contemplated that directly reprogrammed and converted endothelial cells will enhance blood vessel regeneration in the tissues where blood vessels have been damaged. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 18/000865 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/34 (20130101) Original (OR) Class A61K 38/1709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) C12N 15/86 (20130101) C12N 2506/1307 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141620 | Wilson et al. |
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| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
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| INVENTOR(S) | Thomas S. Wilson (San Leandro, California); Michael Keith Hearon (College Station, Texas); Jane P. Bearinger (Berwyn, Pennsylvania) |
| ABSTRACT | This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/082726 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 48/00 (20190201) B29C 48/03 (20190201) B29C 61/06 (20130101) B29C 67/20 (20130101) B29C 71/02 (20130101) B29C 71/04 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/83 (20130101) C08G 18/673 (20130101) C08G 18/675 (20130101) C08G 18/722 (20130101) C08G 18/758 (20130101) C08G 18/3206 (20130101) Original (OR) Class C08G 63/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141661 | Padron |
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| FUNDED BY |
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| APPLICANT(S) | H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida) |
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| INVENTOR(S) | Eric Padron (Tampa, Florida) |
| ABSTRACT | As disclosed herein, the long non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is overexpressed and prognostic in Chronic Myelomonocytic Leukemia (CMML). MALAT1 depletion is disclosed herein as therapeutic strategy for treating CMML and other MALAT1 overexpressing leukemias. Also disclosed herein is a method of treating a subject with a leukemia that involves co-administering to the subject a MALAT1 silencing agent and a therapeutically effective amount of a differentiation agent, such as all-trans retinoic acid (ATRA). |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/624125 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/203 (20130101) A61K 31/573 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141664 | Shawber et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
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| INVENTOR(S) | Carrie J. Shawber (Township of Washington, New Jersey); June K. Wu (New York, New York); Ajit Muley (San Mateo, California) |
| ABSTRACT | Provided herein are methods and compositions for treating and preventing vascular malformations including lymphatic, venous, capillary, arteriovenous, and combinations thereof. Methods of treatment and prevention include the administration of proteasome inhibitors, omipalisib, disulfiram, and agents which target genes in the PI3K/AKT/mTOR or RAS/RAF/MAPK pathways, including but not limited to Pik3ca, Pik3r3, Tsc2, Rasa1, Map2k2, and Glmn. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/984734 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) Original (OR) Class A61K 31/145 (20130101) A61K 31/407 (20130101) A61K 31/501 (20130101) A61K 38/06 (20130101) A61K 38/07 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141925 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
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| INVENTOR(S) | Tiezhi Zhang (St. Louis, Missouri); Qinghao Chen (St. Louis, Missouri); Shuang Zhou (St. Louis, Missouri); Yuewen Tan (St. Louis, Missouri) |
| ABSTRACT | A CT scanning method compensates gantry motion blurring in projection measurement based on synchronized focal spot movement and detector data shifting. Tube power is increased by moving the focal on the target and reducing focal spot dwell duration. The CT scanning method is used on helical CT and cone beam with a rotating anode source and CBCT and TBCT with a linear array x-ray source. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 18/053551 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/4021 (20130101) Original (OR) Class A61B 6/4435 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142111 | Katz |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
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| INVENTOR(S) | David M. Katz (Cleveland, Ohio) |
| ABSTRACT | A method of treating a pervasive development disorder in a juvenile or adolescent subject in need thereof includes administering subanesthetic doses of an NMDAR antagonist at a first dosing interval effective to alleviate at least one neurological symptom associated with the pervasive development disorder, wherein time between subanesthetic doses of the NMDAR antagonist during the first dosing interval is at least 12 hours. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867364 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/135 (20130101) Original (OR) Class A61K 31/453 (20130101) A61K 31/498 (20130101) A61K 31/5365 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142283 | BAKER et al. |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
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| INVENTOR(S) | David BAKER (Seattle, Washington); Matthew BICK (Seattle, Washington); TJ BRUNETTE (Seattle, Washington) |
| ABSTRACT | Disclosed herein are junction polypeptides that can be used, for example, to join together protein building blocks via a rigid fusion to generate a wide range of protein shapes; fusion proteins comprising such junction polypeptides, polymers thereof, and methods for designing such junction polypeptides. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/759175 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) C07K 14/47 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1068 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) Original (OR) Class G16B 35/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142496 | CHENG |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
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| INVENTOR(S) | Ke CHENG (Raleigh, North Carolina) |
| ABSTRACT | A stem cell biomimetic microparticle and methods of manufacture are provided that comprise a core nanoparticle and an outer layer disposed on the core nanoparticle, the core nanoparticle comprising at least one stem cell-derived secreted factor or a population of stem-cell derived exosomes embedded in a biocompatible polymer core nanoparticle, and an outer layer obtained from a cell membrane. Also provided is a method of treating a pathological condition of a patient by delivering to the patient a composition comprising the stem cell biomimetic microparticle comprising at least one stem cell-derived secreted factor or population of stem cell-derived exosomes embedded in a biocompatible polymer core microparticle and an outer layer derived from red blood cell membranes or platelet membranes disposed on the biocompatible polymer core microparticle. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/253159 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/4866 (20130101) A61K 9/5068 (20130101) A61K 35/28 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 9/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142508 | Burns et al. |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); Instituto Carlos Slim de la Salud, A.C. (Mexico, D.F., Mexico) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); Instituto Carlos Slim de la Salud, A.C. (Mexico, D.F., Mexico) |
| INVENTOR(S) | Sean M. Burns (Boston, Massachusetts); Bridget K. Wagner (Cambridge, Massachusetts); Amedeo Vetere (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are methods for inducing insulin secretion in a glucose-dependent manner and compounds for use in these methods. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991792 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101) Acyclic or Carbocyclic Compounds C07C 235/84 (20130101) Heterocyclic Compounds C07D 213/30 (20130101) C07D 231/12 (20130101) C07D 237/08 (20130101) C07D 261/08 (20130101) C07D 413/12 (20130101) Original (OR) Class C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142852 | Khanna et al. |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Hemant Khanna (Sutton, Massachusetts); Laura Moreno Leon (Shrewsbury, Massachusetts) |
| ABSTRACT | Aspects of the disclosure relate to compositions and methods for modulating expression of certain RPGR retinitis pigmentosa GTPase regulator (RPGR) proteins in a cell or subject. In some embodiments the disclosure provides expression vectors encoding one or more RPGR proteins and/or one or more inhibitory nucleic acids that target certain isoforms of RPGR, for example RPGRCONST. In some aspects, the disclosure relates to methods of treating retinitis pigmentosa (RP) in a subject by administering compositions that modulate RPGR expression or activity. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/909148 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142910 | Bassaganya-Riera et al. |
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| APPLICANT(S) | Landos Biopharma, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | Landos Biopharma, Inc. (Blacksburg, Virginia) |
| INVENTOR(S) | Josep Bassaganya-Riera (Blacksburg, Virginia); Adria Carbo Barrios (Blacksburg, Virginia); Richard Gandour (Blacksburg, Virginia); Julian D. Cooper (Blacksburg, Virginia); Raquel Hontecillas (Blacksburg, Virginia) |
| ABSTRACT | Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/085018 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4439 (20130101) Acyclic or Carbocyclic Compounds C07C 65/40 (20130101) Heterocyclic Compounds C07D 213/69 (20130101) C07D 213/79 (20130101) C07D 307/60 (20130101) C07D 307/68 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142955 | ISSADORE et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Aaron ISSADORE (Philadelphia, Pennsylvania); Zijian YANG (Philadelphia, Pennsylvania); Erica L. CARPENTER (Wyndmoor, Pennsylvania); Ben Z. STANGER (Merion Station, Pennsylvania) |
| ABSTRACT | Disclosed herein are methods for evaluating a disease or a condition in a subject. More particularly, disclosed herein are methods for determining or diagnosing a disease, methods for classifying a stage of a disease, methods for treating a disease or methods for assessing the efficacy of a therapy for treating a disease based on the measurement and the computational analysis of various disease-specific biomarkers. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/905129 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1013 (20130101) C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143102 | Anwar et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Moshiur M. Anwar (San Francisco, California); Catherine Park (San Francisco, California); Bernhard Boser (Berkeley, California) |
| ABSTRACT | The disclosed apparatus, systems and methods relate to the use of optical nanoparticles in the illumination and imaging of tissues such as cancer tissues. Optical nanoparticles such as upconverting nanoparticles can be introduced into a patient and illuminated at a first time and wavelength and then imaged at a second time and wavelength to improve resolution and reduce imager size. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/639722 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/043 (20130101) A61B 1/000094 (20220201) A61B 1/0684 (20130101) A61B 1/3132 (20130101) A61B 5/0091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143228 | AMARA et al. |
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| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rama Rao AMARA (Atlanta, Georgia); Sailaja GANGADHARA (Atlanta, Georgia); Nanda Kishore ROUTHU (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to methods of promoting immune responses against coronavirus, such as SARS-CoV-2, and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for coronavirus comprising administering to the subject a composition disclosed herein. In certain embodiments, the composition comprises a recombinant virus such as recombinant MVA that encodes a coronavirus spike protein. In certain embodiments, the coronavirus spike protein comprises a proline mutation at position 986. In certain embodiments, the coronavirus spike protein comprises a proline mutation at position 987. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/918431 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/53 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2770/20022 (20130101) C12N 2770/20023 (20130101) C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143233 | Sajda et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); MEDICAL UNIVERSITY OF SOUTH CAROLINA (Charleston, South Carolina) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); MEDICAL UNIVERSITY OF SOUTH CAROLINA (Charleston, South Carolina) |
| INVENTOR(S) | Paul Sajda (New York, New York); Truman R. Brown (Mt. Pleasant, South Carolina); Mark S. George (Sullivans Island, South Carolina); Robin Goldman (Madison, Wisconsin); Josef Faller (Afing, Austria); Jaycee Doose (Charleston, South Carolina); James McIntosh (New York, New York); Joshua B. Teves (Charleston, South Carolina); Yida Lin (Seattle, Washington); Golbarg T. Saber (Chicago, Illinois); Aidan Blankenship (Charleston, South Carolina); Spiro P. Pantazatos (New York, New York); Xiaoxiao Sun (Chongqing, China PRC) |
| ABSTRACT | The present subject matter relates to techniques for systems and methods for determining alpha phase in brain of subjects undergoing depressive disorder. The disclosed system for a closed-loop operation in simultaneous functional magnetic resonance imaging (fMRI)-electroencephalogram (EEG)-transcranial magnetic stimulation (TMS), can include a processor that be configured to receive and process a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and/or transcranial magnetic stimulation (TMS) pulse simultaneously. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054447 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class A61B 5/4064 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) A61N 2/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143415 | ZOU |
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| FUNDED BY |
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| APPLICANT(S) | Georgia State Research Foundation, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ming-Hui ZOU (Atlanta, Georgia) |
| ABSTRACT | The present invention provides methods for detecting and/or treating a subject having an aneurysm or at risk for developing an aneurysm. It has been discovered that a key metabolite of the kynurenine (Kyn) pathway, a major route for the metabolism of essential amino acid tryptophan (Trp) into nicotinamide adenine dinucleotide (NAD+), plays a critical role in the formation of aneurysms, for example abdominal aortic aneurysms. In particular, it has been discovered that 3-Hydroxyanthranilic acid (3-HAA), a product of kynureninase (KYNU), plays a causative role in the formation of aneurysms by, for example exerting pro-inflammatory effects on vascular smooth muscle cells. It has further been discovered that elevated levels of 3-HAA are indicative of the presence and/or progression of an aneurysm, and 3-HAA levels correlate with the size (aortic diameter) of the aneurysm. |
| FILED | Monday, July 04, 2022 |
| APPL NO | 17/810620 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/197 (20130101) A61K 31/423 (20130101) A61K 31/426 (20130101) A61K 31/664 (20130101) A61K 31/4965 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143470 | WOLAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis W. WOLAN (La Jolla, California); Ian A. WILSON (La Jolla, California); Yao YAO (Seattle, Washington); Seiya KITAMURA (San Diego, California); Nicholas C. WU (Champaign, Illinois); Rameshwar U. KADAM (San DIego, California); Chang-Chun LEE (San Diego, California) |
| ABSTRACT | Disclosed are small molecule inhibitors of influenza HA, and methods of using them to treat or prevent HA-mediated diseases and conditions. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/915559 |
| CURRENT CPC | Heterocyclic Compounds C07D 413/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143626 | Kermekchiev et al. |
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| FUNDED BY |
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| APPLICANT(S) | DNA POLYMERASE TECHNOLOGY, INC. (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milko B. Kermekchiev (St. Louis, Missouri); Zhian Zhang (Ballwin, Missouri) |
| ABSTRACT | Amino acid substitutions that provide for increased elongation rates, resistance to PCR inhibitors, and reverse transcriptase activity of Thermus aquaticus (Taq) DNA polymerase enzymes are provided. Also provided are related methods of using the Taq DNA polymerase enzymes to rapidly detect nucleic acids of interest in crude biological samples, without DNA/RNA extraction. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 18/045369 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144076 | Wald et al. |
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| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lawrence L. Wald (Cambridge, Massachusetts); Clarissa Zimmerman-Cooley (Boston, Massachusetts); Patrick C. McDaniel (Boston, Massachusetts); Sai Abitha Srinivas (Boston, Massachusetts) |
| ABSTRACT | Asymmetric, single-channel radio frequency (“RF”) coils are provided for use with portable or other low-field magnetic resonance imaging (“MRI”) systems. In general, the asymmetric, single-channel RF coils make use of asymmetric, optimized winding configurations in order to reduce B1+ inhomogeneities and to reduce signal sensitivity outside of the desired imaging field-of-view (“FOV”). |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/996857 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/6803 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/34007 (20130101) G01R 33/34084 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144336 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joshua R. Smith (Seattle, Washington); Xingyi Shi (Seattle, Washington) |
| ABSTRACT | Examples of charging systems are described which may utilize a network of resonator circuits. Control methods are described which may locate a charging location at which an electronic device is placed proximate the charging system and identify a path of resonator circuits to activate to charge the electronic device. Individual resonator circuits in the path may be activated by selecting a resonant frequency of the resonator circuit such that power may be transferred by the resonator circuit at an operating frequency. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/905163 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0063 (20130101) H02J 7/342 (20200101) H02J 50/005 (20200101) H02J 50/12 (20160201) H02J 50/80 (20160201) H02J 50/502 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144342 | Sussillo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior Unversity (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David Sussillo (Portola Valley, California); Jonathan C. Kao (Stanford, California); Sergey Stavisky (San Francisco, California); Krishna V. Shenoy (Palo Alto, California) |
| ABSTRACT | A brain machine interface (BMI) to control a device is provided. The BMI has a neural decoder, which is a neural to kinematic mapping function with neural signals as input to the neural decoder and kinematics to control the device as output of the neural decoder. The neural decoder is based on a continuous-time multiplicative recurrent neural network, which has been trained as a neural to kinematic mapping function. An advantage of the invention is the robustness of the decoder to perturbations in the neural data; its performance degrades less—or not at all in some circumstances—in comparison to the current state decoders. These perturbations make the current use of BMI in a clinical setting extremely challenging. This invention helps to ameliorate this problem. The robustness of the neural decoder does not come at the cost of some performance, in fact an improvement in performance is observed. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/937745 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/044 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144405 | Walter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Roland B. Walter (Seattle, Washington); George S. Laszlo (Seattle, Washington) |
| ABSTRACT | A suite of novel human anti-CD33 antibodies is described. The provided antibodies are pan-binders, binding the C2-set Ig-like domain in the presence or absence of the V-set Ig-like domain of CD33 or are V-set binders, binding the V-set Ig-like domain of CD33. The antibodies provide novel therapeutic and diagnostic tools against CD33-related disorders, such as acute myeloid leukemia (AML). |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/907655 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Peptides C07K 16/2809 (20130101) C07K 16/2896 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144767 | Wipf et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittdburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittdburgh, Pennsylvania) |
| INVENTOR(S) | Peter Wipf (Pittdburgh, Pennsylvania); Marie-Celine Frantz (Seine Saint Denis, France) |
| ABSTRACT | Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/093704 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 47/64 (20170801) Acyclic or Carbocyclic Compounds C07C 237/16 (20130101) Heterocyclic Compounds C07D 209/44 (20130101) C07D 209/46 (20130101) C07D 211/58 (20130101) C07D 211/94 (20130101) C07D 221/22 (20130101) C07D 279/06 (20130101) C07D 401/12 (20130101) C07D 417/12 (20130101) C07D 471/08 (20130101) Peptides C07K 5/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144834 | Chou |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Janice J. Chou (North Bethesda, Maryland) |
| ABSTRACT | Modified G6PC (glucose-6-phosphatase, catalytic subunit) nucleic acids and glucose-6-phosphatase-α (G6Pase-α) enzymes with increased phosphohydrolase activity are described. Also described are vectors, such as adeno-associated virus (AAV) vectors, and recombinant AAV expressing modified G6Pase-α. The disclosed AAV vectors and rAAV can be used for gene therapy applications in the treatment of glycogen storage disease, particularly glycogen storage disease type Ia (GSD-Ia), and complications thereof. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 18/058457 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/47 (20130101) A61K 45/06 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 15/66 (20130101) C12N 15/85 (20130101) C12N 15/8645 (20130101) Original (OR) Class Enzymes C12Y 301/03009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144845 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jing Huang (Los Angeles, California); Min Chai (Los Angeles, California); Meisheng Jiang (Thousand Oaks, California); Xudong Fu (Los Angeles, California); Heejun Hwang (Los Angeles, California) |
| ABSTRACT | Disclosed herein are methods and compositions for treating, inhibiting, or reducing hair loss, treating, inhibiting, or reducing pigmentation loss, improving or stimulating hair growth, and/or improving or stimulating pigmentation production in a subject with one or more alpha-ketobutyrate compounds and/or one or more glutarate compounds. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154498 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/365 (20130101) A61K 9/0014 (20130101) A61K 9/0017 (20130101) A61K 31/19 (20130101) Original (OR) Class A61K 31/194 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/00 (20180101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 7/00 (20130101) A61Q 19/02 (20130101) A61Q 19/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144866 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiliang Cheng (Newtown, Pennsylvania); Andrew Tsourkas (Bryn Mawr, Pennsylvania); Ling Qin (Moorestown, Pennsylvania) |
| ABSTRACT | Therapeutic compositions, comprising: an anti-reactive oxygen species agent and a pervious polymersome, the pervious polymersome encapsulating the anti-reactive oxygen species agent, and the pervious polymersome having therein channels defined by a channel diblock copolymer, the channels being arranged so as to retain at least some of the anti-reactive oxygen species agent within the pervious polymersome while allowing reactive oxygen species to pass into the pervious polymersome. Method of treating a patient, comprising: administering an effective amount of a therapeutic composition, the therapeutic composition comprising an anti-reactive oxygen species agent disposed within a pervious polymersome, the pervious polymersome encapsulating the anti-reactive oxygen species agent, and the pervious polymersome having therein channels defined by a channel diblock copolymer, the channels being arranged so as to retain at least some of the anti-reactive oxygen species agent within the pervious polymersome while allowing reactive oxygen species to pass into the pervious polymersome. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 18/054586 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1273 (20130101) A61K 38/446 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/02 (20180101) A61P 19/02 (20180101) A61P 39/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145065 | LIVENGOOD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TAKEDA VACCINES, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | TAKEDA VACCINES, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | Jill A. LIVENGOOD (Cambridge, Massachusetts); Holli Giebler (Cambridge, Massachusetts); Hansi Dean (Cambridge, Massachusetts); Tatsuki Satou (Hikari-shi, Japan); Raman Rao (Singapore, Singapore); Jackie Marks (Cambridge, Massachusetts); Mark Lyons (Cambridge, Massachusetts); Asae Shintani (Hikari-shi, Japan); James Gifford (Cambridge, Massachusetts); Sushma Kommareddy (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/931887 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/5252 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145121 | Gillanders et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Gillanders (St. Louis, Missouri); Ted Hansen (North Potomac, Maryland); S. Peter Goedegebuure (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to compositions and methods of treating Triple Negative Breast Cancer (TNBC) in a human subject. A method of treating TNBC in a human subject includes administering a therapeutically effective amount of a neoantigen vaccine composition comprising a fusion protein comprising at least one TNBC-associated neoantigen epitope joined to a mutant ubiquitin protein, or a nucleic acid molecule encoding such a protein. |
| FILED | Wednesday, August 31, 2022 |
| APPL NO | 17/823937 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) C07K 14/4748 (20130101) Original (OR) Class C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 2800/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145185 | Chapelin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fanny Chapelin (Lexington, Kentucky); Roberto Gedaly (Lexington, Kentucky); Aman Khurana (Lexington, Kentucky); Francesc Marti (Lexington, Kentucky) |
| ABSTRACT | The present disclosure generally relates to methods and compositions for obtaining magnetic resonance images of labelled cells. The methods include internalizing a superparamagentic iron oxide nanoparticle within a desired population of cells and then observing the cells through the contrast provided in magnetic resonance imaging. The methods are applicable for in vivo use to monitor desired cells types. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054387 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/16 (20130101) Original (OR) Class A61K 49/1875 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145281 | FAIRCHILD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KAREN D. FAIRCHILD (Charlottesville, Virginia); Douglas E. LAKE (Charlottesville, Virginia) |
| ABSTRACT | Provided are a system and method for predicting risk of diagnosis for Autism Spectrum Disorder (ASD) using neonatal analytics. Such analytics assess heart rate pattern data for a given period of admission in a Neonatal Intensive Care Unit to determine correlation with heart rate characteristics indicative of ASD. Relative to a finding of one or more correlations, such analytics offer the opportunity for earliest screening and intervention for ASD, as appropriate. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/909170 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/024 (20130101) A61B 5/7275 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145297 | Gonen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tamir Gonen (Los Angeles, California); Michael Martynowycz (Los Angeles, California); Johan Hattne (Los Angeles, California) |
| ABSTRACT | Methods of collecting diffractionpatterns from a microcrystal having an ordered array of a molecule are disclosed, which nclude using an exposure rate of at most 0.02 electrons per square angstrom per second on the microcrystal and using a direct electron etector to record electron diffraction patterns. Also disclosed are methods of determining a structural model for a molecule, identifying a material present in a trace amount within a sample, identifying a polymorph, and identifying the stereochemistry of a molecule. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/920659 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/2055 (20130101) G01N 23/20058 (20130101) Original (OR) Class G01N 33/6803 (20130101) G01N 2458/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145514 | ALBERINI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cristina Maria ALBERINI (New York, New York); Emmanuel CRUZ (New York, New York) |
| ABSTRACT | Provided are methods for treatment of seizures associated with neurodevelopmental disorders, such as Angelman Syndrome and autism comprising administering to an individual a composition comprising IGF-2. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/996862 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/30 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145599 | Falo, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwelth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louis Falo, Jr. (Wexford, Pennsylvania); Andrea A. Gambotto (Pittsburgh, Pennsylvania); Geza Erdos (Wexford, Pennsylvania) |
| ABSTRACT | Provided herein are microneedle array devices for delivery of recombinant adenovirus particles, methods of making the devices, and used for the devices. The microneedle array devices are storage-stable at 4° C., retaining adenovirus infectivity for at least one month. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/917873 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/235 (20130101) A61K 2039/53 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0023 (20130101) A61M 2037/0053 (20130101) A61M 2037/0061 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145832 | Marasco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul D. Marasco (Lakewood, Ohio); Jonathon S. Schofield (Davis, California); Courtney E. Shell (Round Rock, Texas); Zachary C. Thumser (Cleveland, Ohio); Dylan Beckler (Lyndhurst, Ohio); Jonathan Sakai (Rocky River, Ohio) |
| ABSTRACT | A cognitive illusion of ownership over a proxy extremity (e.g. a hand) is provided by discordant touch and visual information to a user. While the user feels the touch on their real extremity, they see a corresponding touch on the proxy extremity. The user's internally modeled reality is then updated to move the felt location of the real extremity to the seen location of the proxy extremity. As a result, the user embodies the proxy extremity, thereby disembodying the real extremity. Pain associated with medical procedures performed on the real extremity is then mitigated. And because an epileptic brain is less stringent when resolving conflict between what is seen and what is felt, correlations in time or space can shift attribution of the sensation of the felt touch on the user's real extremity to the location of the proxy extremity. This can be helpful in treating and/or diagnosing epilepsy. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980164 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/52 (20130101) A61M 21/02 (20130101) Original (OR) Class A61M 2021/0022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146239 | BOGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| INVENTOR(S) | Dale L. BOGER (La Jolla, California); Zhi-Chen WU (San Diego, California) |
| ABSTRACT | A series of vancomycin C-terminus guanidine modifications are disclosed that improve antimicrobial activity, enhance the durability of antimicrobial action against selection or induction of resistance, and provide two synergistic mechanisms of action independent of D-Ala-D-Ala binding that cause inhibition of cell wall biosynthesis, while inducing bacterial cell permeability. A contemplated compound contains two combined peripheral modifications, a (4-chlorobiphenyl)methyl (CBP) and C-terminus guanidine modification, that provide new treatments against not only vancomycin-sensitive, but especially vancomycin-resistant bacteria. The data demonstrate that the synergistic behavior of the peripheral modifications requires the presence of both the CBP and guanidine modifications in a single molecule versus their combined use as an equimolar mixture of singly modified compounds. A prototypical member of the series, G3-CBP-vancomycin (15), exhibits no hemolytic activity, displays no mammalian cell growth inhibition, and possesses improved and especially attractive in vivo pharmacokinetic (PK) properties. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/918448 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 9/008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146253 | Beane-Ebel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts); HEALTH RESEARCH, INC. (Buffalo, New York) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts); HEALTH RESEARCH, INC. (Buffalo, New York) |
| INVENTOR(S) | Jennifer E. Beane-Ebel (Fort Collins, Colorado); Avrum E. Spira (Newton, Massachusetts); Marc Lenburg (Brookline, Massachusetts); Mary E. Reid (Buffalo, New York); Sarah Mazzilli (Abington, Massachusetts) |
| ABSTRACT | The technology described herein is directed to methods of treating and diagnosing bronchial premalignant lesions, e.g. by determining the lesion subtype using one or more biomarkers described herein. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/093066 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5023 (20130101) Original (OR) Class G01N 33/5091 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146256 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Frank Jonathan LEE (Minneapolis, Minnesota); Yushun WAN (Chongqing City, China PRC); Jian SHANG (Zhengzhou City, China PRC) |
| ABSTRACT | The present disclosure provides an isolated or purified SARS-CoV-2 Receptor Binding Domain (RBD) polypeptide and cells for producing such a polypeptide, as well as compositions and methods thereof. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/918835 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/02 (20130101) C07K 2319/21 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20022 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146286 | SAITO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (Kanagawa, Japan); TOSOH CORPORATION (Yamaguchi, Japan) |
| ASSIGNEE(S) | JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (Kanagawa, Japan); TOSOH CORPORATION (Yamaguchi, Japan) |
| INVENTOR(S) | Yoshiro SAITO (Kanagawa, Japan); Ryosuke NAKAMURA (Kanagawa, Japan); Noriaki ARAKAWA (Kanagawa, Japan); Yasuo OHNO (Kanagawa, Japan); Takashi IZUMI (Kanagawa, Japan); Motonobu SATO (Ibaraki, Japan); Takayoshi NISHIYA (Tokyo, Japan); Michiko AIHARA (Kanagawa, Japan) |
| ABSTRACT | Biomarkers for diagnosing the disease activity, disease severity or disease type of severe cutaneous adverse drug reactions (SCARs) such as drug-induced hypersensitivity syndrome and Stevens-Johnson syndrome/toxic epidermal necrolysis are provided. Also provided is a method of testing SCARs, comprising measuring the expression of at least one protein selected from the group consisting of stratifin, TNF receptor superfamily member 8 (CD30/TNFRSF8), interleukin-1 receptor antagonist (IL-1Ra), and TNF receptor superfamily member 6B (DcR3/TNFRSF6B) in a sample derived from a subject. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/918449 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/50 (20130101) G01N 2800/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146391 | Marr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Marr (Golden, Colorado); Keith Neeves (Golden, Colorado) |
| ABSTRACT | Methods and systems are provided for aerosolization of individual building blocks of medical microrobots and subsequent in situ assembly into microrobots capable of medical intervention deep within lung tissues of a subject. The methods and systems of the disclosure may allow for microrobot-based therapy of pulmonary diseases that have previously been difficult to effectively treat using conventional therapeutic approaches. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/983933 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 11/001 (20140204) A61M 11/003 (20140204) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146428 | Madabhushi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Golnoush Asaeikheybari (Cleveland Heights, Ohio); Amogh Hiremath (Cleveland, Ohio); Mina K. Chung (Shaker Heights, Ohio); John Barnard (Cleveland, Ohio) |
| ABSTRACT | Systems, methods, and apparatus are provided for generating an atlas image of a branched structure and predicting a likelihood of success of certain treatments based on the atlas image. In one example, a method includes registering a plurality of images of instances of a branched structure to generate an aligned image for a cohort, wherein the branched structure comprises a central structure and at least one primary branch connected to the central structure; for each primary branch of the branched structure, iteratively registering respective portions of a plurality of images containing the primary branch to generate an aligned image portion of the primary branch; and applying a control grid of the aligned image portion of the primary branch to respective image portions containing the central structure and the other primary branches prior to iteratively registering a next primary branch; and generating an atlas image for the cohort based on the aligned image portions. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/984624 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 7/33 (20170101) Original (OR) Class G06T 2207/10081 (20130101) G06T 2207/20224 (20130101) G06T 2207/30041 (20130101) G06T 2207/30048 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) G06T 2207/30101 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 10/764 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146821 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Evan R. Daugharthy (Cambridge, Massachusetts); Richard C. Terry (Carlisle, Massachusetts) |
| ABSTRACT | The present disclosure provides methods that combine RNA fluorescent in situ sequencing (FISSEQ) with other molecular detection modalities, forming an integrated panomic detection platform. In various embodiments, the present disclosure provides systems and methods to prepare a biological sample to preserve the spatial relationships of biomolecules of interest within the biological sample for FISSEQ detection. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/884808 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) A61L 2400/16 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 2300/0636 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6834 (20130101) C12Q 1/6874 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146829 | Narayanan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramesh Narayanan (Cordova, Tennessee); Thamarai Ponnusamy (Mamphis, Tennessee); Duane D. Miller (Collierville, Tennessee); Yali He (Germantown, Tennessee); Dong-Jin Hwang (Arlington, Tennessee) |
| ABSTRACT | This invention is directed to selective androgen receptor degrader (SARD) compounds including heterocyclic rings and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject. |
| FILED | Wednesday, August 24, 2022 |
| APPL NO | 17/894482 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Original (OR) Class A61K 31/415 (20130101) A61K 31/416 (20130101) A61K 31/422 (20130101) A61K 31/4188 (20130101) A61K 31/4192 (20130101) A61K 31/4245 (20130101) A61K 31/4439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146860 | Kamm et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger Kamm (Cambridge, Massachusetts); Huu Tuan Nguyen (Cambridge, Massachusetts); Sharon Wei Ling Lee (Cambridge, Massachusetts) |
| ABSTRACT | Microfluidic devices with open ports and gel channels for forming perfusable hydrogel vascular networks with holes or ports for samples, and methods of making and using, are provided which integrate interstitial flows to an ex vivo vascularized tissue model. Samples of cells, spheroids, organoids, and tissues can be used for screening of agents for efficacy, toxicity and dosage. The devices create interstitial flow from the top of the gel hole, through the sample toward the vascular networks, and/or luminal flows generated by a pressure difference between two media channels across the vascular network. This system is useful for studying angiogenesis, immune cell migration and testing new immunotherapy drug candidates. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 17/678729 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) A01N 1/0284 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 25/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0691 (20130101) C12N 5/0697 (20130101) C12N 2513/00 (20130101) C12N 2533/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146870 | Peterson |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Blake Peterson (Columbus, Georgia) |
| ABSTRACT | This disclosure relates to methods of quantifying affinity and selectivity of compounds for target proteins in living cells. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 18/051711 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1055 (20130101) Original (OR) Class C12N 15/1086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146923 | Chou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tsui-Fen Chou (Pasadena, California); Shan Li (Pasadena, California); Feng Wang (Pasadena, California); Nadia Houerbi (Pasadena, California) |
| ABSTRACT | Provided herein are methods and compositions for inhibiting p97, for the treatment of a cancer in a subject, or a symptom thereof. Upon treatment, the cancer, or a symptom thereof is reduced in the subject. Additionally, methods for measuring sensitivity of a subject to p97 inhibition, methods of assessing a pharmaceutical agent for p97 inhibition activity, and methods of assessing the effect of a pharmaceutical agent for p97 inhibition activity in a subject are provided herein. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/982901 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/1137 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146932 | BenMohamed |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lbachir BenMohamed (Irvine, California) |
| ABSTRACT | Multi-epitope, pan-coronavirus recombinant vaccine compositions featuring a combination of highly conserved B cell epitopes, highly conserved CD4+ T cell epitopes, and highly conserved CD8+ T cell epitopes, at least one of which is derived from a non-spike protein. The present invention uses several immuno-informatics and sequence alignment approaches and multiple immunological assays in vitro using human blood and saliva samples from COVID patients and healthy patients to identify several human B cells, CD4+ and CD8+ T cell epitopes that are highly conserved and antigenic in vitro. The Invention also used an in vivo unique mouse model of ACE2/HLA-A0201/HLA-DR triple transgenic mouse model to test the immunogenicity and the protective efficacy against SARS-CoV-2 infection and COVID-Like symptoms, of the identified B and T cell epitopes and of the resulting multi-epitope-pan-Coronavirus vaccine candidates. The vaccine compositions herein have the potential to provide long-lasting B and T cell immunity regardless of Coronaviruses mutations. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046862 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 37/04 (20180101) Peptides C07K 14/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146937 | Porreca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank Porreca (Tucson, Arizona); Hisakatsu Ito (Tucson, Arizona); Edita Navratilova (Tucson, Arizona) |
| ABSTRACT | Chronic pain patients complain about sleep disturbance with a high probability, while sleep loss increases pain in chronic pain patients. Sleep problems and pain promote a vicious spiral, suggesting a need for simultaneous treatment of both. The present invention provides a method to treat pain-related sleep disorders through distribution of a therapeutic amount of a KOR antagonist. The use of KOR antagonist could be a novel therapeutic agent for sleep disturbance in chronic pain patients. Additionally, KOR antagonists could be used to improve sleep in other conditions, such as depression or general anxiety disorder, where KOR signaling is induced. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/906541 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/485 (20130101) Original (OR) Class A61K 31/4709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/04 (20180101) A61P 25/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146950 | LIANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Weibin LIANG (Princeton, New Jersey); James C. STURM (Princeton, New Jersey); Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weibin LIANG (Princeton, New Jersey); James C. STURM (Princeton, New Jersey) |
| ABSTRACT | Provided are microfluidic sorting devices comprising: a sample inlet, a single column comprising a plurality of bumping features configured for lateral displacement situated in a microfluidic channel, and a plurality of outlets, wherein the single column creates a main channel and a secondary channel in the microfluidic channel, wherein the sample inlet, the plurality of outlets, and the main channel and secondary channel are in fluid connection. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/907523 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/027 (20130101) B01L 2200/0652 (20130101) B01L 2300/0864 (20130101) B01L 2400/086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146985 | Levner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Levner (Boston, Massachusetts); Je-Hyuk Lee (Allston, Massachusetts); George M. Church (Brookline, Massachusetts); Michael Super (Lexington, Massachusetts) |
| ABSTRACT | The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/146483 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6816 (20130101) C12Q 1/6837 (20130101) C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147004 | Green et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alexander Green (Chestnut Hill, Massachusetts); Duo Ma (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Green (Chestnut Hill, Massachusetts); Duo Ma (Tempe, Arizona) |
| ABSTRACT | The present invention provides loop-mediated riboregulators for the detection of SARS-CoV-2. Also provided are DNA constructs encoding the loop-mediated riboregulators and methods of using the loop-mediated riboregulators to detect the presence of SARS-CoV-2 in a sample. |
| FILED | Thursday, August 25, 2022 |
| APPL NO | 17/822213 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147035 | Ray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sangeeta Ray (Ellicott City, Maryland); Martin G. Pomper (Baltimore, Maryland) |
| ABSTRACT | Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer are disclosed. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/049288 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0482 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) C07B 2200/05 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/003 (20130101) C07F 7/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147702 | Lee |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wonjae Lee (Palo Alto, California) |
| ABSTRACT | Described herein is a microfluidic chip comprising a first channel in fluid communication with an adjacent second channel through a opening, wherein the height of the first channel and the second channel are chosen to generate sufficient surface tension at the opening such that a liquid injected into the first channel or the second channel is substantially confined within the first channel or the second channel, respectively, or that flow of the liquid therebetween is controlled, the surface tension producing a non-physical microfluidic barrier that limits or selectively controls passage of the liquid. Also described are in vitro microphysiological systems that use such microfluidic chips in modeling the structure and functions of human organs, such as a blood-brain barrier, and studying in vivo-like physiological responses of such organs to various investigative or therapeutic agents. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/920541 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/0652 (20130101) B01L 2300/161 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147733 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Cassandra Elizabeth Callmann (Evanston, Illinois) |
| ABSTRACT | The disclosure is generally related to nanoparticles have an oxidized tumor cell lysate encapsulated therein and oligonucleotides on the surface thereof. Methods of making and using the nanoparticles are also provided herein. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/917871 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 47/64 (20170801) A61K 47/545 (20170801) A61K 47/6915 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 15/117 (20130101) C12N 2310/17 (20130101) C12N 2310/315 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147744 | Allbritton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy L. Allbritton (Seattle, Washington); Yuli Wang (Lynnwood, Washington); Christopher E. Sims (Seattle, Washington); Cecilia Villegas Novoa (Seattle, Washington) |
| ABSTRACT | Provided are new strategies, methods and systems, described herein as vasoactive intestinal peptide (VIP)-assisted air-liquid-interface (ALI) culture, to significantly increase the number of enteroendocrine (EEC) and enterochromaffin (EC) cells over the traditional submerged culture, while at the same time maintaining a high barrier integrity of monolayers. The new strategies, methods and systems overcome the limitations of the existing EEC enrichment methods by maintaining high cell viability and barrier integrity and without requiring complicated procedures of cocultures or genetic engineering/induction. The created EEC-enriched, contiguous monolayer platform acts as a robust analytical tool to enable functional studies of hormone secretion from EEC cells with high signal background ratio and repeatability. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/916683 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 25/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0679 (20130101) Original (OR) Class C12N 2501/30 (20130101) C12N 2501/415 (20130101) C12N 2503/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147832 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianhua Yu (Duarte, California); Michael A. Caligiuri (Pasadena, California) |
| ABSTRACT | Provided herein, inter alia, are compositions and methods including recombinant oncolytic viruses expressing human IL-15 and human IL-15Rα-sushi domain for the treatment of cancer and immune disorders. The recombinant oncolytic viruses may be used in combination with immune cells expressing chimeric antigen receptors (CAR) targeting EGFR and EGFR mutants. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/794913 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/5443 (20130101) C07K 14/7155 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147855 | YOON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Young-Sup YOON (Atlanta, Georgia); Kyung Hee KIM (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to methods of making vascular smooth muscle like cells from precursor stem cells. In certain embodiments the vascular smooth muscle like cells are able to contract in response to vasoactive agents, In certain embodiments, the methods comprise contacting pluripotent stem cells with a mesoderm induction growth medium, followed by replicating the cells in a serum-free vascular smooth muscle cell growth medium in the presence of collagen, and purifying replicated cells that express cadherin-2. In certain embodiments, the purified cells are used to treat or prevent a cardiovascular disease or condition. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/917315 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0661 (20130101) Original (OR) Class C12N 2501/11 (20130101) C12N 2501/15 (20130101) C12N 2501/115 (20130101) C12N 2501/135 (20130101) C12N 2506/45 (20130101) C12N 2509/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148179 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Wang (Tucson, Arizona); Chunlong Ma (Tucson, Arizona) |
| ABSTRACT | This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical agents which function as inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral replication and/or SARS-CoV-2 related viral 3CL protease (Mpro) activity. The invention further relates to methods of treating and/or ameliorating symptoms related to conditions caused by the SARS-CoV-2 virus (e.g., COVID-19), comprising administering to a subject (e.g., a human patient) a composition comprising one or more pharmaceutical agents which function as inhibitors of SARS-CoV-2 viral replication and/or inhibitors of SARS-CoV-2 related Mpro activity. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/917789 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 38/05 (20130101) A61K 38/06 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Acyclic or Carbocyclic Compounds C07C 323/41 (20130101) Peptides C07K 5/081 (20130101) Original (OR) Class C07K 5/0606 (20130101) C07K 5/0808 (20130101) C07K 5/0812 (20130101) C07K 5/06034 (20130101) C07K 5/06078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148317 | Gibbs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | Summer L. Gibbs (West Linn, Oregon); Lei G. Wang (Portland, Oregon); Connor W. Barth (Portland, Oregon) |
| ABSTRACT | This invention concerns novel oxazine-based fluorophore compounds useful in in vivo nerve imaging, as well as compositions comprising them and methods for their use. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/794932 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0028 (20130101) Original (OR) Class Heterocyclic Compounds C07D 265/38 (20130101) C07D 413/04 (20130101) C07D 413/14 (20130101) C07D 498/04 (20130101) C07D 498/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148447 | Flusberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Pacific Biosciences of California, Inc. (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Flusberg (Atlanta, Georgia); Stephen Turner (Eugene, Oregon); Jon Sorenson (Alameda, California); Kevin Travers (Menlo Park, California); Cheryl Heiner (La Honda, California) |
| ABSTRACT | Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid. |
| FILED | Wednesday, August 26, 2020 |
| APPL NO | 17/003388 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/32 (20130101) A61F 2/30721 (20130101) Original (OR) Class A61F 2002/30062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230141261 | Moser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Alex E. Moser (Alexandria, Virginia); Nicholas D. Pierce (Ruther Glen, Virginia); Cherelda V. Stephens (Stafford, Virginia) |
| ABSTRACT | A technique for determining armor weight requirements for a specific set of ballistic threats at specific stand-offs or velocities allows for the selection of armor that is not excessively heavy, thus improving mobility, comfort, and survivability. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/862621 |
| CURRENT CPC | Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/00 (20130101) Electric Digital Data Processing G06F 16/24575 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141310 | Voigt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Christopher A. Voigt (Belmont, Massachusetts); Fang-Yuan Chang (Somerville, Massachusetts) |
| ABSTRACT | Disclosed herein, in some embodiments, are vectors encoding biosynthetic enzymes from gut microbiome-derived bacterium (e.g., Clostridia enzymes), engineered cells comprising the vectors, and methods of using biosynthetic enzymes from gut microbiome-derived bacterium (e.g., Clostridia enzymes) to produce fatty acid amides. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/812156 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/02 (20130101) Original (OR) Class Enzymes C12Y 203/01041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141370 | Mi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zetian Mi (Ann Arbor, Michigan); David Laleyan (Ann Arbor, Michigan); Ping Wang (Ann Arbor, Michigan) |
| ABSTRACT | A method of fabricating a semiconductor device includes providing a substrate, implementing a growth procedure to form a semiconductor layer supported by the substrate, performing an anneal of the semiconductor layer, the anneal being conducted at a higher temperature than the growth procedure, and repeating the growth procedure and the anneal. The anneal is conducted at or above a decomposition temperature for the semiconductor layer. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/912830 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/025 (20130101) C30B 29/403 (20130101) C30B 33/02 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/0254 (20130101) H01L 21/02381 (20130101) H01L 21/02546 (20130101) H01L 21/02631 (20130101) Original (OR) Class H01L 21/02667 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141422 | Underwood et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon Underwood (Brick Township, New Jersey); Glenn Minko (Staten Island, New York) |
| ABSTRACT | Various embodiments that relate to a circular disk configured to radiate a signal. The radiating disk can include edge openings. Within these edge openings power supplies can rest. When the power supplies function, they can cause the circular disk to radiate with either a dipole pattern or a cardioid pattern. A controller can manage how these power supplies function depending on if the dipole pattern or the cardioid pattern is desired. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/522950 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/12 (20130101) H01Q 9/045 (20130101) Original (OR) Class H01Q 9/0464 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141643 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David R. Smith (Durham, North Carolina); Zhiqin Huang (Chapel Hill, North Carolina); Daniel L. Marks (Durham, North Carolina) |
| ABSTRACT | Various examples of out-of-plane multicolor waveguide holography systems, methods of manufacture, and methods of use are described herein. In some examples, a multicolor waveguide holography system includes a planar waveguide to convey optical radiation between a grating coupler and a metasurface hologram. The grating coupler may be configured to couple out-of-plane optical radiation of three different color incident at three different angles into the planar waveguide. The combined multicolor optical radiation may be conveyed by the waveguide to the metasurface hologram. The metasurface hologram may diffractively decouple the three colors of optical radiation for off-plane propagation to form a multicolor holographic image in free space. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/149253 |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/2645 (20130101) Original (OR) Class G03H 2222/13 (20130101) G03H 2223/23 (20130101) G03H 2225/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141664 | Shawber et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carrie J. Shawber (Township of Washington, New Jersey); June K. Wu (New York, New York); Ajit Muley (San Mateo, California) |
| ABSTRACT | Provided herein are methods and compositions for treating and preventing vascular malformations including lymphatic, venous, capillary, arteriovenous, and combinations thereof. Methods of treatment and prevention include the administration of proteasome inhibitors, omipalisib, disulfiram, and agents which target genes in the PI3K/AKT/mTOR or RAS/RAF/MAPK pathways, including but not limited to Pik3ca, Pik3r3, Tsc2, Rasa1, Map2k2, and Glmn. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/984734 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) Original (OR) Class A61K 31/145 (20130101) A61K 31/407 (20130101) A61K 31/501 (20130101) A61K 38/06 (20130101) A61K 38/07 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141697 | Chu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Hetao Chu (Chengdu, China PRC); Jinsong Leng (Harbin, China PRC); Ray H. Baughman (Dallas, Texas); Xinghao Hu (Plano, Texas); Na Li (Milwaukee, None); Carter S. Haines (Murphy, Texas); Shaoli Fang (Richardson, Texas); Zhong Wang (Dallas, Texas); Mu Jiuke (Plano, Texas) |
| ABSTRACT | Previous electrochemically-powered yarn muscles cannot be usefully operated between extreme negative and extreme positive potentials, since strokes during electron injection and during hole injection partially cancel because they are in the same direction. Unipolar-stroke carbon nanotube yarn muscles are described in which muscle strokes are additive between extreme negative and extreme positive potentials, and stroke increases with potential scan rate. These electrochemical artificial muscles include an electrically conducting twisted or coiled yarn and a material that dramatically shifts the potential of zero charge of the electrochemically actuated yarn. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 17/380746 |
| CURRENT CPC | Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/16 (20130101) D02G 3/26 (20130101) D02G 3/441 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2401/16 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/012 (20210801) F03G 7/025 (20210801) Original (OR) Class F03G 7/029 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142352 | Derkacs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SolAero Technologies Corp. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Derkacs (Albuquerque, New Mexico); John Hart (Albuquerque, New Mexico); Zachary Bittner (Albuquerque, New Mexico) |
| ABSTRACT | An inverted metamorphic multijunction solar cell including an upper first solar subcell, a second solar subcell and a third solar subcell. The upper first solar subcell has a first band gap and positioned for receiving an incoming light beam. The second solar subcell is disposed below and adjacent to, and is lattice matched with, the upper first solar subcell, and has a second band gap smaller than the first band gap. The third solar subcell is disposed below the second solar subcell, and is composed of a GaAs base and emitter layer so as to optimize the efficiency of the solar cell after exposure to radiation. In some implementations, at least one of the solar subcells has a graded band gap throughout its thickness. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/149902 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/041 (20141201) H01L 31/065 (20130101) Original (OR) Class H01L 31/1844 (20130101) H01L 31/03046 (20130101) H01L 31/06875 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142413 | Fisher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric C. Fisher (Poway, California); Marcio C. de Andrade (San Diego, California); Brian A. Higa (San Diego, California); Michael O'Brien (San Diego, California) |
| ABSTRACT | A receiver for detecting at least one electromagnetic signal while the receiver is moving relative to the Earth's magnetic field, the receiver comprising: an SQUID array for generating an output that is a transfer function of SQUID array magnetic flux that is supplied from a combination of an oscillating magnetic field of the at least one electromagnetic signal, the Earth's magnetic field, and a bias magnetic field; a bias-tee configured to divide the SQUID array output into a DC signal and an RF signal; a memory store configured to store a plurality of voltage and flux bias values, wherein each voltage value has a corresponding flux bias value that results in maximum SQUID array sensitivity; and a logic circuit configured to find a voltage value in the memory store that most closely matches the DC signal, and to apply to the SQUID array a flux bias corresponding to the most closely matched voltage value. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/460767 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0354 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142819 | Turer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); UPMC (Pittsburgh, Pennsylvania); Department of the Army (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Michael Turer (Pittsburgh, Pennsylvania); Cameron Good (Joppa, Maryland); Benjamin Schilling (Pittsburgh, Pennsylvania); Heng Ban (Wexford, Pennsylvania); Jason S. Chang (Bridgeville, Pennsylvania); J. Peter Rubin (Pittsburgh, Pennsylvania); Lucas A. Dvoracek (Pittsburgh, Pennsylvania) |
| ABSTRACT | A biocontainment assembly for use with a patient suspected of having or diagnosed with a transmissible disease(s) capable of respiratory, airborne, contact, or droplet transmission includes a housing configured to be positioned over and at least partially enclose a head, neck, and/or torso of the patient. A sidewall of the housing includes an open portion contiguous with an at least partially pen bottom portion of the housing, sized to fit over at least a portion of the head, neck, and/or a torso of the patient. The housing also includes an airflow opening for evacuating fluid from an interior defined by the housing. The assembly also includes a drape configured to extend across the open portion of the sidewall having a first portion removably connected to the housing and an opposing second portion configured to be draped over the torso, abdomen, waist, and/or legs of the patient. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/917890 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 46/20 (20160201) A61B 90/05 (20160201) Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 10/005 (20130101) Original (OR) Class A61G 10/023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142846 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Kyle Christopher Smith (Champaign, Illinois); Erik Richard Reale (Martinez, California); Irwin Cunnie Loud, IV (Oak Park, Illinois); Vu Quoc Do (Urbana, Illinois) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, a porous electrode that includes a porous layer, and a pattern of flow channels defined in the porous layer, wherein a first flow channel in the pattern of flow channels has a shape that at least partially approximates a cube-root profile. Additional embodiments are disclosed. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980017 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/861 (20130101) H01M 4/8626 (20130101) H01M 8/188 (20130101) Original (OR) Class H01M 8/04432 (20130101) H01M 8/04783 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142896 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Evelyn Wang (Cambridge, Massachusetts); Cody Jacobucci (Pilesgrove, New Jersey); Xiangyu LI (Somerville, Massachusetts); Bachir EL FIL (Cambridge, Massachusetts) |
| ABSTRACT | A simplified method of making an adsorbent layer can permit design and analysis of sorption systems having improved performance can include generation of one dimensional channels. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/982727 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/3078 (20130101) B01J 20/3236 (20130101) Original (OR) Class B01J 20/3238 (20130101) B01J 20/28085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143048 | Larson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natalie M. Larson (Cambridge, Massachusetts); Jochen Mueller (Baltimore, Maryland); Jennifer A. Lewis (Cambridge, Massachusetts) |
| ABSTRACT | A printhead comprises a plurality of ink cartridges and a nozzle, where the nozzle and the ink cartridges are configured to rotate together about an axis during printing. The nozzle includes a nozzle body comprising an inlet end, an outlet end, and one or more internal passageways extending through the nozzle body from the inlet end to the outlet end. The one or more internal passageways terminate at one or more outlets at or near the outlet end. The nozzle also includes plurality of nozzle inlets at the inlet end for delivery of flowable inks into the internal passageways, where each nozzle inlet is in fluid communication with a dispensing end of one of the ink cartridges. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/982877 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/255 (20170801) B29C 64/264 (20170801) B29C 64/336 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143102 | Anwar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Moshiur M. Anwar (San Francisco, California); Catherine Park (San Francisco, California); Bernhard Boser (Berkeley, California) |
| ABSTRACT | The disclosed apparatus, systems and methods relate to the use of optical nanoparticles in the illumination and imaging of tissues such as cancer tissues. Optical nanoparticles such as upconverting nanoparticles can be introduced into a patient and illuminated at a first time and wavelength and then imaged at a second time and wavelength to improve resolution and reduce imager size. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/639722 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/043 (20130101) A61B 1/000094 (20220201) A61B 1/0684 (20130101) A61B 1/3132 (20130101) A61B 5/0091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143233 | Sajda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); MEDICAL UNIVERSITY OF SOUTH CAROLINA (Charleston, South Carolina) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); MEDICAL UNIVERSITY OF SOUTH CAROLINA (Charleston, South Carolina) |
| INVENTOR(S) | Paul Sajda (New York, New York); Truman R. Brown (Mt. Pleasant, South Carolina); Mark S. George (Sullivans Island, South Carolina); Robin Goldman (Madison, Wisconsin); Josef Faller (Afing, Austria); Jaycee Doose (Charleston, South Carolina); James McIntosh (New York, New York); Joshua B. Teves (Charleston, South Carolina); Yida Lin (Seattle, Washington); Golbarg T. Saber (Chicago, Illinois); Aidan Blankenship (Charleston, South Carolina); Spiro P. Pantazatos (New York, New York); Xiaoxiao Sun (Chongqing, China PRC) |
| ABSTRACT | The present subject matter relates to techniques for systems and methods for determining alpha phase in brain of subjects undergoing depressive disorder. The disclosed system for a closed-loop operation in simultaneous functional magnetic resonance imaging (fMRI)-electroencephalogram (EEG)-transcranial magnetic stimulation (TMS), can include a processor that be configured to receive and process a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and/or transcranial magnetic stimulation (TMS) pulse simultaneously. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054447 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class A61B 5/4064 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) A61N 2/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143306 | Cabahug et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | T-Worx Holdings, LLC (Sterling, Virginia) |
| ASSIGNEE(S) | T-Worx Holdings, LLC (Sterling, Virginia) |
| INVENTOR(S) | Eric Cabahug (Fairfax, Virginia); James Dodd (Linden, Virginia); John Schroeder (Leesburg, Virginia); Hector Tapia (Ashburn, Virginia); Ben Feldman (Reston, Virginia) |
| ABSTRACT | The present invention is related to weapons systems. In particular, the present invention is directed to accessory attachment systems for rifles and small arms weapons that enable attached accessory devices to draw power from a central power source and communicate with the user and/or other devices. The present invention embodies firearm systems comprising at least one mounting rail comprising at least one power connection, at least one power source, at least one rail accessory comprising a rail grabber or mount, wherein the at least one rail accessory receives electrical power from the power source. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877608 |
| CURRENT CPC | Smallarms, e.g Pistols, Rifles; Accessories Therefor F41C 23/16 (20130101) F41C 27/00 (20130101) Original (OR) Class Weapon Sights; Aiming F41G 11/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143686 | Koemel |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Koemel (Stillwater, Oklahoma) |
| ABSTRACT | Thermal insulation blankets and methods of using the same to repair articles, such as components of turbine engines are disclosed. The thermal insulation blankets are a multilayer composite material that includes: a first flexible fiberglass fabric layer having two sides that are coated with a coating that covers the fiberglass fibers; an intermediate second fiberglass insulation blanket layer made of continuous glass fibers; and a third layer of flexible heat reflective material. The method involves wrapping a component, such as a component of a turbine engine, with one or more thermal insulation blankets in order to retain heat within the confines of a prescribed area for installing or removing parts with a precision fitment. The blankets allow enough heat to induce even thermal expansion of the components. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522295 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/024 (20130101) B32B 5/262 (20210501) B32B 7/09 (20190101) B32B 2250/03 (20130101) B32B 2250/20 (20130101) B32B 2255/02 (20130101) B32B 2255/26 (20130101) B32B 2260/021 (20130101) B32B 2260/048 (20130101) B32B 2262/101 (20130101) B32B 2262/0269 (20130101) B32B 2307/304 (20130101) B32B 2307/518 (20130101) B32B 2556/00 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/005 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/80 (20130101) F05D 2300/611 (20130101) F05D 2300/5024 (20130101) F05D 2300/6012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144342 | Sussillo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior Unversity (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David Sussillo (Portola Valley, California); Jonathan C. Kao (Stanford, California); Sergey Stavisky (San Francisco, California); Krishna V. Shenoy (Palo Alto, California) |
| ABSTRACT | A brain machine interface (BMI) to control a device is provided. The BMI has a neural decoder, which is a neural to kinematic mapping function with neural signals as input to the neural decoder and kinematics to control the device as output of the neural decoder. The neural decoder is based on a continuous-time multiplicative recurrent neural network, which has been trained as a neural to kinematic mapping function. An advantage of the invention is the robustness of the decoder to perturbations in the neural data; its performance degrades less—or not at all in some circumstances—in comparison to the current state decoders. These perturbations make the current use of BMI in a clinical setting extremely challenging. This invention helps to ameliorate this problem. The robustness of the neural decoder does not come at the cost of some performance, in fact an improvement in performance is observed. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/937745 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/044 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144796 | DePoy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DeepSig Inc. (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel DePoy (Arlington, Virginia); Timothy Newman (Arlington, Virginia); Nathan West (Arlington, Virginia); Tamoghna Roy (Arlington, Virginia); Timothy James O'Shea (Arlington, Virginia); Jacob Gilbert (Arlington, Virginia) |
| ABSTRACT | Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for positioning a radio signal receiver at a first location within a three dimensional space; positioning a transmitter at a second location within the three dimensional space; transmitting a transmission signal from the transmitter to the radio signal receiver; processing, using a machine-learning network, one or more parameters of the transmission signal received at the radio signal receiver; in response to the processing, obtaining, from the machine-learning network, a prediction corresponding to a direction of arrival of the transmission signal transmitted by the transmitter; computing an error term by comparing the prediction to a set of ground truths; and updating the machine-learning network based on the error term. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587640 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4052 (20130101) G01S 13/426 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145015 | Hammig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Hammig (Dexter, Michigan); Nicholas Kotov (Ann Arbor, Michigan) |
| ABSTRACT | A detector includes a substrate including a matrix of aramid nanofibers, a distribution of nanoparticles across the matrix of aramid nanofibers, and a plurality of organic capping ligands. Each organic capping ligand of the plurality of organic capping ligands bonds a respective nanoparticle of the plurality of nanoparticles to a respective aramid nanofiber of the matrix of aramid nanofibers. The detector further includes first and second electrodes disposed along opposite sides of the substrate to capture charges generated by photons or particles incident upon the detector. Each nanoparticle of the plurality of nanoparticles has a semiconductor composition. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/912834 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/366 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/085 (20130101) Original (OR) Class H01L 31/0224 (20130101) H01L 31/0384 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145368 | Xiong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chi Xiong (Yorktown Heights, New York); Jason S. Orcutt (Katonah, New York); Ricardo Alves Donaton (Cortlandt Manor, New York); Stephen M. Gates (Ossining, New York); SWETHA KAMLAPURKAR (Yorktown Heights, New York); Abram L Falk (Port Chester, New York) |
| ABSTRACT | Techniques regarding microwave-to-optical quantum transducers are provided. For example, one or more embodiments described herein can include an apparatus that can include a microwave resonator on a dielectric substrate and adjacent to an optical resonator, and a photon barrier structure at least partially surrounding an optical resonator, wherein the photon barrier structure is configured to provide isolation of the microwave resonator from optical photons in the dielectric substrate outside the photon barrier structure. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191178 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0356 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145418 | Whiteley |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Whiteley (Sunnyvale, California) |
| ABSTRACT | The present disclosure relates to improved electronic structures for propagating logic states between superconducting digital logic gates using a three-junction interferometer in a receiver circuit to reduce reflecting signals that otherwise result in distortions in the signals being transmitted between the gates. Other improved electronic structures comprise passive transmission lines (PTLs) with transmission line matching circuitry that has previously been avoided. The matching circuity minimizes generation and propagation of spurious pulses emitted by Josephson junctions used in the digital logic gates. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181869 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/035 (20130101) Original (OR) Class Pulse Technique H03K 19/195 (20130101) Electric solid-state devices not otherwise provided for H10N 60/12 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145532 | Broderick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Inovio Pharmaceuticals, Inc. (Plymouth Meeting, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kate Broderick (San Diego, California); Jay McCoy (Temecula, California); Stephen V. Kemmerrer (San Diego, California); Feng Lin (San Diego, California); Rune Kjeken (Oslo, Norway) |
| ABSTRACT | A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/814703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 2039/53 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) Original (OR) Class A61N 1/0502 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145627 | Leng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haoyang Leng (State College, Pennsylvania); Yongke Yan (Port Matilda, Pennsylvania); Shashank Priya (State College, Pennsylvania) |
| ABSTRACT | Embodiments relate to a piezoelectric ceramic and methods of making the same that is suitable for use as a high-power piezoelectric ceramic, and in particular a piezoelectric ceramic that exhibits both good hard properties and good soft properties. Embodiments involve generating the piezoelectric ceramic via the combination of chemical modification/doping and/or a texturing method so that the piezoelectric material exhibits a large figure of merit, as well as other hard and soft properties. The chemical modification involves Cu and Mn doping a piezoelectric material composition having a relaxor-lead titanate based ferroelectric structure. The texturing involves templated grain growth (TGG) texturing using a BaTiO3 (BT) template. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 17/909468 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/499 (20130101) Original (OR) Class C04B 2235/3236 (20130101) C04B 2235/3255 (20130101) C04B 2235/3267 (20130101) C04B 2235/3281 (20130101) Electric solid-state devices not otherwise provided for H10N 30/045 (20230201) H10N 30/097 (20230201) H10N 30/8548 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145832 | Marasco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul D. Marasco (Lakewood, Ohio); Jonathon S. Schofield (Davis, California); Courtney E. Shell (Round Rock, Texas); Zachary C. Thumser (Cleveland, Ohio); Dylan Beckler (Lyndhurst, Ohio); Jonathan Sakai (Rocky River, Ohio) |
| ABSTRACT | A cognitive illusion of ownership over a proxy extremity (e.g. a hand) is provided by discordant touch and visual information to a user. While the user feels the touch on their real extremity, they see a corresponding touch on the proxy extremity. The user's internally modeled reality is then updated to move the felt location of the real extremity to the seen location of the proxy extremity. As a result, the user embodies the proxy extremity, thereby disembodying the real extremity. Pain associated with medical procedures performed on the real extremity is then mitigated. And because an epileptic brain is less stringent when resolving conflict between what is seen and what is felt, correlations in time or space can shift attribution of the sensation of the felt touch on the user's real extremity to the location of the proxy extremity. This can be helpful in treating and/or diagnosing epilepsy. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980164 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/52 (20130101) A61M 21/02 (20130101) Original (OR) Class A61M 2021/0022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146098 | Tuncdemir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Safakcan Tuncdemir (Linden, Pennsylvania); Joshua Gambal (Linden, Pennsylvania); Gareth Knowles (Linden, Pennsylvania) |
| ASSIGNEE(S) | QorTek, Inc. (Linden, Pennsylvania) |
| INVENTOR(S) | Safakcan Tuncdemir (Linden, Pennsylvania); Joshua Gambal (Linden, Pennsylvania); Gareth Knowles (Linden, Pennsylvania) |
| ABSTRACT | A semi-wave transducer is provided that comprises a circular or elliptic transduction shell that has sidewalls captured between identical opposing upper and lower circular or elliptic conical segments (platens), each having a surface geometry of a radially symmetric wave shape that includes a center region and a rim wherein the distance between the center region of the upper and lower platens greater than the distance between the rims of the upper and lower platens. In some embodiments, the surface geometry of the platens may be a jinc function or a recurve function. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/911945 |
| CURRENT CPC | Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 9/22 (20130101) G10K 9/121 (20130101) Original (OR) Class Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146816 | Fischer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INNOVAPREP LLC (Drexel, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Fischer (Lee's Summit, Missouri); Bryan Long (Odessa, Missouri); Steven D. Graham (Drexel, Missouri); Sidney J. Spry (Lexington Park, Maryland); Alec Adolphson (Raymore, Missouri); John D. Birkenholz (Kansas City, Missouri); Andrew E. Page (Smithton, Missouri); David S. Alburty (Drexel, Missouri) |
| ABSTRACT | Devices, systems, and methods are disclosed which relate to using a use large area surface sampler with invertible bag for collection of biological and non-biological particles prior to subsequent analysis. The large area surface sampler with invertible bag uses an inverted bag with bonded sampling material to first serve as a sampling device followed by the bag being turned right side out and the captured particles being extracted inside of the bag. The device includes measures for sealing liquid in the sampling material using a protective cup at time of manufacture. This enables users to simply remove the protective cup and perform wet surface sampling prior to turning the bag right side out and removing captured particles from the sampling material with repeated compressions. The described device, systems and methods allow users to capture and elute surface samples for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/984204 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/505 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147042 | STROBEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Institution of Washington (Washington, District of Columbia) |
| ASSIGNEE(S) | Carnegie Institution of Washington (Washington, District of Columbia) |
| INVENTOR(S) | Timothy STROBEL (Washington, District of Columbia); Li ZHU (Washington, District of Columbia) |
| ABSTRACT | The present invention provides carbon-based clathrate compounds, including a carbon-based clathrate compound that includes a clathrate lattice with atoms of at least one element selected from the group consisting of carbon and boron as a host cage structure; guest atoms encapsulated within the clathrate lattice; and, substitution atoms that may be substituted for at least one portion of the carbon and boron atoms that constitute the clathrate lattice. In one embodiment, the invention provides a carbon-based clathrate compound of the formula LaB3C3. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/951939 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/30 (20200101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/38 (20130101) C01P 2006/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147091 | Gressick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Barron Associates, Inc. (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William T. Gressick (Charlottesville, Virginia); Brian R. Clark (Charlottesville, Virginia); Clifford Schultz (Perkins, Oklahoma) |
| ABSTRACT | Embodiments of a controlled odor emission system and device include an odor presentation port tube and an odor tray securely retained against a platform, a valve housing securable to the platform adjacent the tray, a valve secured within the valve housing and an actuator for moving the valve. By controlling movement of the valve, precise amounts of an odor can be dispensed under programmatic control for training animals. Further, a system incorporating a central control unit and a reward dispenser in communication with an odor emission device to facilitate animal training. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/096839 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 5/0275 (20130101) A01K 15/02 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 9/032 (20130101) A61L 9/035 (20130101) Original (OR) Class A61L 2209/11 (20130101) A61L 2209/134 (20130101) Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 13/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147160 | Gienger, IV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edwin B. Gienger, IV (Washington, District of Columbia); John B. Helder (Columbia, Maryland); Morgana M. Trexler (Baltimore, Maryland); Catherine M. Carneal (Silver Spring, Maryland); Christopher J. Dohopolski (Baltimore, Maryland); James C. Gurganus (Aberdeen Proving Ground, Maryland); William H. Mermagen (Aberdeen Proving Ground, Maryland); Michael S. Horsmon (Gunpowder, Maryland) |
| ABSTRACT | A blunt force sensor array for application to a non-planar surface includes a flexible thin-film substrate, a plurality of force sensors secured to the flexible thin-film substrate proximate to a center measurement point, a strain gauge secured on the flexible thin-film substrate proximate to the center measurement point, and a sensor interface configured to connect to external measurement and control circuitry. The sensor interface may be electrically connected to each of the force sensors and the strain gauge via traces disposed on the flexible thin-film substrate. The flexibility and shape of the flexible thin-film substrate may permit the blunt force sensor array to be applied to the non-planar surface to detect forces and strains experienced by the non-planar surface in response to a blunt force event on the non-planar surface. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/588538 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4504 (20130101) Original (OR) Class A61B 2562/18 (20130101) A61B 2562/164 (20130101) A61B 2562/0219 (20130101) A61B 2562/0261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147345 | Adams et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard J. Adams (Charlestown, Massachusetts); Gordon O. Salmela (Framingham, Massachusetts) |
| ABSTRACT | A spring-loaded ball valve includes a spring, a first pin, a second pin, and a handle. The spring is configured to apply pressure to the first pin and second pin when the ball valve is in both the fully open and fully closed positions. The spring applies maximum torque when the ball valve is in the fully open or fully closed position to ensure the valve remains in the fully open or fully closed position. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/454131 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 5/0647 (20130101) F16K 31/563 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147640 | RIVERA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELYSIUM ROBOTICS LLC (Cedar Park, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rodrigo Alvarez-Icara RIVERA (Cedar Park, Texas) |
| ABSTRACT | Disclosed herein are methods and systems for making DEMAs by forming a mechanical and electrical connection between a bundle of dielectric elastomer microfibers comprising a direct mechanical connection between the face of each microfiber and a supportive element, and a direct electrical connection between the core of all microfibers and a metallic contact. Also disclosed are dielectric elastomer (DE) microfibers comprised of an inner electrode, a hollow tube, and an outer electrode, wherein the ratio alpha between the outer and inner diameter maximizes the electromechanical performance of such fiber as an actuator. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/995353 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/12 (20130101) B25J 9/1075 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147873 | Hirbe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Angela Hirbe (St. Louis, Missouri); Dana Borcherding (St. Louis, Missouri); Neha Amin (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Angela Hirbe (St. Louis, Missouri); Dana Borcherding (St. Louis, Missouri); Neha Amin (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of methods of treating cancer in a subject comprising administering a TYK2 inhibiting agent and a MEK inhibiting agent. In some embodiments, the subject has a malignant peripheral nerve sheath tumor (MPNST), neurofibromatosis Type 1 (NF1) cancer predisposition syndrome, benign plexiform neurofibromas (PN), or atypical neurofibromas (ANNUBP). Methods of inhibiting TYK2 and MEK in a subject in need thereof are also provided. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 18/053935 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/166 (20130101) A61K 31/501 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147927 | FISHER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| INVENTOR(S) | Nathan T. FISHER (Westminster, Maryland); Charles A. RILEY (Washington, District of Columbia); Joseph S. KRIVDA (Kensington, Maryland); Steven S. HONG (Alexandria, Virginia); Timothy C. BLOOD, Jr. (Silver Spring, Maryland); Jonathan N. PERKINS (Rockville, Maryland); Douglas S. RUHL (DuPont, Washington) |
| ABSTRACT | An airway management isolation enclosure and a method for protecting medical personnel from infectious agents when treating a patient having an infectious disease, comprising: (a) a frame that is positioned over the head and anterior thoracic region of the patient; (b) a transparent barrier supported by frame, which covers and forms a seal around the head and anterior thoracic region of the patient and allows medical personnel to create sealable entry ports; and (c) an air flow entry and a vacuum exit connection to direct the infectious agents in the form of respiratory droplets and particles produced by the patient to flow away from the head of the patient and out of the transparent covering while the medical personnel manages the airway and upper aerodigestive tract of the patient. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/917605 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 90/05 (20160201) Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 10/005 (20130101) Original (OR) Class A61G 10/023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148063 | Crouch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David D. Crouch (Farragut, Tennessee); Hooman Kazemi (Thousand Oaks, California); Alexander Borisovich Brailovsky (Irvine, California) |
| ABSTRACT | A planar conductive millimeter-wave lens includes: a planar conductive plate with a first surface and a second surface, wherein the first surface is parallel to the second surface; a plurality of openings from the first surface through the planar conductive plate to the second surface, where an axis of each opening is perpendicular to the first surface and the second surface. A size of each opening is a function of a position of said each opening on the planar conductive plate such that an insertion phase collectively imposed by the openings on an incident wave causes the incident wave to pass through the first surface and the planar conductive plate, exit from the second surface and to focus at a predetermined distance from the second surface. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524644 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/38 (20130101) H01Q 19/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148108 | CARLISLE, IV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Graf Research Corporation (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward CARLISLE, IV (Atlanta, Georgia); Jonathan GRAF (Blacksburg, Virginia); Scott HARPER (Blacksburg, Virginia); Steven FREDERIKSEN (Christiansburg, Virginia) |
| ABSTRACT | A computer system obtains and/or assists in creation of a natural language description file corresponding to a design, where the design is a hardware design or a software design and processes the natural language description file to extract semantic expressions. One or more intermediate representation data structures is generated from selected ones of the semantic expressions. Each intermediate representation data structure includes natural language design objects, natural language design object properties, and relationships between natural language design objects and/or natural language design object properties. The computer system transforms each intermediate representation data structure into one or more corresponding design verification statements derived from the natural language description file. Those design verification statements are subsequently evaluated against one or more design implementation files corresponding to the design. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/850275 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/398 (20200101) Original (OR) Class G06F 40/30 (20200101) G06F 40/284 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148273 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ASCENTIA IMAGING, INC. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Johnson (Boulder, Colorado); Edward R. Dowski, JR. (Steamboat Springs, Colorado) |
| ABSTRACT | A coded localization system includes a plurality of optical channels arranged to cooperatively capture information from a scene. Each optical channel includes (i) a respective multi-pixel detector and (ii) a respective localization code, located between the respective multi-pixel detector and the scene, that modifies electromagnetic energy passing therethrough. Each localization code (i) includes at least one of an amplitude mask, a phase mask, and a polarizer, and (ii) differs from the respective localization code of each other of the plurality of optical channels. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/986518 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/002 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/16 (20130101) G01S 19/42 (20130101) G01S 19/48 (20130101) G01S 19/485 (20200501) Systems for Controlling or Regulating Non-electric Variables G05D 1/02 (20130101) G05D 1/0251 (20130101) G05D 1/0278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148397 | Tassev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing HVPE heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and ternary-forming gasses (V/VI group precursor), to form a heteroepitaxial growth of a binary, ternary, and/or quaternary compound on the substrate; wherein the carrier gas is H2, wherein the first precursor gas is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the ternary-forming gasses comprise at least two or more of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), H2Te (hydrogen telluride), SbH3 (hydrogen antimonide, or antimony tri-hydride, or stibine), H2S (hydrogen sulfide), NH3 (ammonia), and HF (hydrogen fluoride); flowing the carrier gas over the Group II/III element; exposing the substrate to the ternary-forming gasses in a predetermined ratio of first ternary-forming gas to second ternary-forming gas (1tf:2tf ratio); and changing the 1tf:2tf ratio over time. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/046950 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/024 (20130101) H01L 21/02387 (20130101) H01L 21/02538 (20130101) H01L 21/02551 (20130101) H01L 21/02568 (20130101) H01L 21/02658 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148437 | HAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Seunghoon HAN (Seoul, South Korea); Amir ARBABI (Pasadena, California); Andrei FARAON (Pasadena, California); Sungwoo HWANG (Seoul, South Korea); Jangwoo YOU (Seoul, South Korea); Byounglyong CHOI (Seoul, South Korea); Hyeonsoo PARK (Suwon-si, South Korea) |
| ABSTRACT | Provided an imaging apparatus including a first optical device, a second optical device disposed such that light transmitted through the first optical device is incident on the second optical device, and a third optical device disposed such that light transmitted through the second optical device is incident on the third optical device, wherein at least one of the first optical device, the second optical device, and the third optical device includes a plurality of nanostructures, and heights of at least two nanostructures of the plurality of nanostructures are different from each other. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 16/800468 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 3/08 (20130101) G02B 5/1876 (20130101) G02B 9/10 (20130101) G02B 9/12 (20130101) G02B 9/14 (20130101) Original (OR) Class G02B 13/003 (20130101) G02B 13/18 (20130101) G02B 13/0035 (20130101) G02B 13/0055 (20130101) G02B 2207/101 (20130101) Pictorial Communication, e.g Television H04N 5/2254 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 999/99 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148461 | Glavin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Glavin (Springboro, Ohio); Christopher Muratore (Kettering, Ohio); Melani K. Muratore (Kettering, Ohio) |
| ABSTRACT | A process of making sensors and sensor arrays that provided real time notification of any centerline deviation. Such production process can be adjusted in real time. Thus, large numbers of units can be made—even in millions of per day—with few if any out of specification units being produced. Such process does not require large-scale clean rooms and is easily configurable. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523721 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/28 (20130101) Original (OR) Class B05D 3/06 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230141283 | CALVEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Hugh CALVEY (Denver, Colorado); Christopher W. JOHNSON (Denver, Colorado) |
| ABSTRACT | Disclosed herein are compositions and methods to improve Cupriavidus sp. as a host for formate conversion. Also disclosed herein are compositions and methods to improve growth of non-naturally occurring Cupriavidus sp. on carbon dioxide, succinate, formate and fructose as sole carbon sources. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 18/053696 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class C12N 15/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141526 | Alahyari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abbas A. Alahyari (Glastonbury, Connecticut); Joseph Turney (Amston, Connecticut); Jagadeesh Kumar Tangudu (South Windsor, Connecticut); Kimberly Rae Saviers (Glastonbury, Connecticut) |
| ABSTRACT | Aircraft electric motors are described. The aircraft electric motors include a motor unit having a rotor and a stator, wherein the stator includes a plurality of windings and cooling channels arranged to provide cooling to the plurality of windings, a drive unit configured to drive operation of the motor unit, and a cooling system having at least one directional feature forming a portion of at least one cooling channel, the at least one directional feature configured to prevent backflow of a cooling fluid that passes through the at least one cooling channel. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/519749 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 33/08 (20130101) Dynamo-electric Machines H02K 5/203 (20210101) Original (OR) Class H02K 9/20 (20130101) H02K 11/33 (20160101) H02K 21/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230141620 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas S. Wilson (San Leandro, California); Michael Keith Hearon (College Station, Texas); Jane P. Bearinger (Berwyn, Pennsylvania) |
| ABSTRACT | This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/082726 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 48/00 (20190201) B29C 48/03 (20190201) B29C 61/06 (20130101) B29C 67/20 (20130101) B29C 71/02 (20130101) B29C 71/04 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/83 (20130101) C08G 18/673 (20130101) C08G 18/675 (20130101) C08G 18/722 (20130101) C08G 18/758 (20130101) C08G 18/3206 (20130101) Original (OR) Class C08G 63/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142019 | Saviers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kimberly Rae Saviers (Glastonbury, Connecticut); Abbas A. Alahyari (Glastonbury, Connecticut); Jagadeesh Kumar Tangudu (South Windsor, Connecticut); Joseph Turney (Amston, Connecticut) |
| ABSTRACT | Aircraft electric motors are described. The aircraft electric motors includes a motor unit having a rotor and a stator, wherein the stator includes a plurality of windings and cooling channels arranged to provide cooling to the plurality of windings, a drive unit configured to drive operation of the motor unit, and a cooling system. The cooling system includes at least one cooling channel integrally formed within at least one winding, wherein the at least one cooling channel comprises an inlet to receive a two-phase cooling fluid and an outlet configured to discharge the two-phase cooling fluid, wherein a cross-sectional area of the at least one cooling channel at the inlet is less than a cross-sectional area of the at least one cooling channel at the outlet. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522118 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 33/08 (20130101) Dynamo-electric Machines H02K 5/20 (20130101) H02K 9/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142862 | Steiner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ford Global Technologies, LLC (Dearborn, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bernd Steiner (Duesseldorf, Germany); Ravi Gopal (Novi, Michigan); Ronald Semel (West Bloomfield, Michigan); Jody Michael Slike (Farmington Hills, Michigan); Jan Mehring (Koeln, Germany) |
| ABSTRACT | Methods and systems are provided for a cooling arrangement. In one example, a system comprises a separator arranged in a block coolant jacket. The separator fluidly separates an upper portion of the block coolant jacket from a lower portion of the block coolant jacket. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/454218 |
| CURRENT CPC | Cooling of Machines or Engines in General; Cooling of Internal-combustion Engines F01P 3/14 (20130101) F01P 5/10 (20130101) Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 1/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143150 | Srinivasan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sudharsanan Srinivasan (Santa Barbara, California); Di Liang (Santa Barbara, California) |
| ABSTRACT | Examples described herein relate to an optical device with an integrated light-emitting structure to generate light and a waveguide integrated capacitor to monitor light. The light-emitting structure may emit light upon the application of electricity to the optical device. The waveguide integrated capacitor may be formed under the light-emitting structure to monitor the light emitted by the light-emitting structure. The waveguide integrated capacitor includes a waveguide region carrying at least a portion of the light. The waveguide region includes one or more photon absorption sites causing the generation of free charge carriers relative to an intensity of the light confined in the waveguide region resulting in a change in the conductance of the waveguide region. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/454410 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4274 (20130101) G02B 6/4295 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143362 | DATSKOS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ALLIANCE FOR SUSTAINABLE ENERGY, LLC (Golden, Colorado); UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Panagiotis George DATSKOS (Golden, Colorado); Nickolay LAVRIK (Knoxville, Tennessee) |
| ABSTRACT | Described herein is using an array of microelectromechanical systems (MEMS) oscillators to produce unique identifiers. At least some of the MEMS oscillators will “couple” or influence each other when exposed to an external stimulus, such that the frequency of the device is not equal to the combination of individual MEMS oscillator frequencies. The frequency of the device provides a unique “fingerprint” that allows the device to be identified with accuracy but is incredibly difficult to copy, meaning the response may be a physical unclonable function (PUF). |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/910697 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/067 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 3/0077 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0866 (20130101) Original (OR) Class H04L 9/3278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143600 | Saviers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kimberly Rae Saviers (Glastonbury, Connecticut); Abbas A. Alahyari (Glastonbury, Connecticut); Jagadeesh Kumar Tangudu (South Windsor, Connecticut); Joseph Turney (Amston, Connecticut) |
| ABSTRACT | Aircraft electric motors are described. The aircraft electric motors include a motor unit having a rotor and a stator, wherein the stator includes a plurality of windings and cooling channels arranged to provide cooling to the plurality of windings, a drive unit configured to drive operation of the motor unit, and a cooling system. The cooling system includes an oscillating heat pipe containing a first working fluid, wherein the oscillating heat pipe is arranged to pick up heat from at least one winding, the oscillating heat pipe having an evaporator section arranged in thermal contact with the at least one winding and a condenser section arranged away from the evaporator section and a heat pickup portion arranged to receive a second working fluid to remove heat from the condenser section of the oscillating heat pipe. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/519766 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 33/08 (20130101) Dynamo-electric Machines H02K 5/203 (20210101) H02K 9/20 (20130101) H02K 9/225 (20210101) Original (OR) Class H02K 11/33 (20160101) H02K 21/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143622 | ROBERTS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ADVANCED MICRO DEVICES, INC. (SANTA CLARA, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DAVID A. ROBERTS (BOXBOROUGH, Massachusetts); GREG SADOWSKI (BOXBOROUGH, Massachusetts); STEVEN RAASCH (BOXBOROUGH, Massachusetts) |
| ABSTRACT | Exemplary embodiments provide thermal wear spreading among a plurality of thermal die regions in an integrated circuit or among dies by using die region wear-out data that represents a cumulative amount of time each of a number of thermal die regions in one or more dies has spent at a particular temperature level. In one example, die region wear-out data is stored in persistent memory and is accrued over a life of each respective thermal region so that a long term monitoring of temperature levels in the various die regions is used to spread thermal wear among the thermal die regions. In one example, spreading thermal wear is done by controlling task execution such as thread execution among one or more processing cores, dies and/or data access operations for a memory. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/152022 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Electric Digital Data Processing G06F 1/20 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/34 (20130101) Original (OR) Class H01L 25/0657 (20130101) H01L 2225/06589 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144017 | REED et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. (New Orleans, Louisiana); THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne Frederick REED (New Orleans, Louisiana); Rick D. MONTGOMERY (New Orleans, Louisiana); Michael Felix DRENSKI (New Orleans, Louisiana); Aide WU (New Orleans, Louisiana) |
| ABSTRACT | Devices and methods for determining the cumulative distribution of a polymer property in a reactor without physical separation of reaction subcomponents. The device includes a means of measuring an instantaneous property of the polymers being produced in a reaction vessel a plurality of times during a polymerization reaction as well as a means of determining the corresponding change in polymer concentration in the reaction vessel between measurements of the instantaneous polymer property. The device also includes a means of computing a statistical distribution appropriate to the polymer characteristic and applying the statistical distribution to a recently measured instantaneous value of the polymer property so as to have an instantaneous distribution of the polymer property and a means of adding together the instantaneous distributions of the polymer property in order to obtain the cumulative distribution of the polymer property in the reactor. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/951721 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0006 (20130101) B01J 2219/002 (20130101) B01J 2219/00186 (20130101) B01J 2219/00218 (20130101) B01J 2219/00231 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 20/56 (20130101) C08F 2400/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/75 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144524 | WOOD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VERSA POWER SYSTEMS, LTD (Danbury, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony WOOD (Calgary, Canada); Zheng TANG (Calgary, Canada); Tahir JOIA (Calgary, Canada) |
| ABSTRACT | A method of manufacturing a proton-conducting fuel cell includes assembling a green anode-electrolyte half-cell by forming an anode substrate layer having an upper surface and a lower surface, forming an anode functional layer on the upper surface of the anode substrate layer, forming an electrolyte layer on an upper surface of the anode functional layer, and forming a stress balancing layer on the lower surface of the anode substrate layer. The method further includes positioning the green anode-electrolyte half-cell on kiln furniture inside a sintering kiln and sintering the green anode-electrolyte half-cell using SSRS to an anode-electrolyte half-cell. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/942468 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8885 (20130101) Original (OR) Class H01M 8/10 (20130101) H01M 2004/8684 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144778 | Kautz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Kautz (Shawnee, Kansas); Marcus Kautz (Arvada, Colorado); David Allendorfer (Olathe, Kansas); Jeremy Sims (Pleasant Hill, Missouri) |
| ABSTRACT | Systems, methods, and devices are provided for producing and using a low-value inductor which is stable at high frequencies, the inductor including a plurality of radial spokes extending between two concentric rings. The inductance of the inductor is controlled by the number and dimensions of the plurality of spokes, as well as the materials of the inductor. In some cases, the inductor is used as a low value inductance standard for directly measuring a low value electrical inductance. |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/521370 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/28 (20130101) Original (OR) Class H01F 27/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144856 | LIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongxia LIU (Clarksville, Maryland); Yonggang YAO (College Park, Maryland); Liangbing HU (Potomac, Maryland); Qi DONG (Newton, Massachusetts) |
| ABSTRACT | One or more reactants are flowed into thermal contact with a heating element in a reactor for a first time period. During a first part of a heating cycle, the one or more reactants are provided with a first temperature by heating with the heating element, such that one or more thermochemical reactions is initiated. The one or more thermochemical reactions includes pyrolysis, thermolysis, synthesis, hydrogenation, dehydrogenation, hydrogenolysis, or any combination thereof. The first heating element operates by Joule heating and has a porous construction that allows gas to flow therethrough. During a second part of the heating cycle, the one or more reactants are provided with a second temperature less than the first temperature, for example, by de-energizing the heating element. A duration of the first time period is equal to or greater than a duration of the heating cycle, which is less than five seconds. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/911159 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 4/008 (20130101) B01J 6/008 (20130101) B01J 15/005 (20130101) Original (OR) Class B01J 19/0013 (20130101) B01J 19/2475 (20130101) B01J 2204/005 (20130101) B01J 2219/00058 (20130101) B01J 2219/00135 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/26 (20130101) C01B 2203/085 (20130101) C01B 2203/0277 (20130101) C01B 2203/1241 (20130101) Ammonia; Cyanogen; Compounds Thereof C01C 1/0417 (20130101) C01C 1/0452 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 7/08 (20130101) C08J 7/12 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 15/08 (20130101) C10G 50/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145097 | Kiran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Mariam Kiran (San Ramon, California); Nicholas Buraglio (Berkeley, California); Scott Campbell (Lake Oswego, Oregon) |
| ABSTRACT | A method and apparatus for dynamically routing traffic from a first network device to a second network device is described. In one implementation, the method includes sampling one or more qualified packets from an ingress stream using neural network classification criteria, appending a flow encapsulation header with the path information, providing the path information to the path computation engine at user approved time intervals, transmitting the packets to destination network device, and collecting real-time network telemetry data. Real-time network telemetry data is stored in a network health database. When a new network transfer is introduced, the system correctly identifies the characteristics of the transfer, in terms of size, throughput, jitter, latency, loss, and completion times. A corrective action is introduced that inputs the current network health information and transfer characteristics by generating corrective control rules to allow the transfer to be optimally routed (e.g., automatically) through the network. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 18/052614 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/16 (20130101) H04L 41/147 (20130101) H04L 47/127 (20130101) Original (OR) Class H04L 47/2483 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145136 | Marks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tobin J. Marks (Evanston, Illinois); Yanshan Gao (Evanston, Illinois); Yosi Kratish (Evanston, Illinois); Jiaqi Li (Evanston, Illinois) |
| ABSTRACT | A method for depolymerizing a polyester may comprise heating a polyester at a temperature and for a period of time in the presence of a supported metal-dioxo catalyst, optionally, in the presence of H2, to induce hydrogenolysis of ester groups in the polyester and provide monomers of the polyester. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/915299 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 51/09 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/16 (20130101) Original (OR) Class C08J 2367/02 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/012 (20180101) C08K 2003/2258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145233 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaowen CHEN (Littleton, Colorado); Michael E. HIMMEL (Littleton, Colorado); Richard T. ELANDER (Evergreen, Colorado); Melvin P. TUCKER (Lakewood, Colorado) |
| ABSTRACT | Disclosed herein are processes for ethanol production from a lignocellulosic feedstock. These processes provide DMR of lignocellulosic biomass comprising two-stage deacetylation followed by mechanical refining so as to increase fermentable sugar yield while reducing hydrolytic enzyme loading requirements. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 17/976303 |
| CURRENT CPC | Derivatives of Natural Macromolecular Compounds C08H 8/00 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145347 | Sampayan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Opcondys, Inc. (Manteca, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Sampayan (Manteca, California); Kristin Cortella Sampayan (Manteca, California) |
| ABSTRACT | Devices, methods and techniques are disclosed to suppress electrical discharge and breakdown in insulating or encapsulation material(s) applied to solid-state devices. In one example aspect, a multi-layer encapsulation film includes a first layer of a first dielectric material and a second layer of a second dielectric material. An interface between the first layer and the second layer is configured to include molecular bonds to prevent charge carriers from crossing between the first layer and the second layer. The multi-layer encapsulation configuration is structured to allow an electrical contact and a substrate of the solid-state device to be at least partially surrounded by the multi-layer encapsulation configuration. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/150000 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/762 (20130101) H01L 29/0611 (20130101) Original (OR) Class H01L 29/0649 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145436 | BAMMES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DIRECT ELECTRON, LP (San Diego, California) |
| ASSIGNEE(S) | DIRECT ELECTRON, LP (San Diego, California) |
| INVENTOR(S) | Benjamin BAMMES (San Diego, California); Robert BILHORN (San Diego, California) |
| ABSTRACT | A method of, and a detector for, performing energy sensitive imaging of ionizing radiation are provided, including acquiring a first frame having a plurality of pixels, each pixel of the plurality having an energy of detection and a location; grouping, into a cluster, pixels of the plurality having an energy of detection above a predetermined threshold and a location along with at least one other pixel also having an energy of detection above the predetermined threshold and being within a predetermined distance of the location; summing the energy of detection of all pixels within the grouped cluster to determine a cluster energy; determining a location of the cluster based on a distribution and an intensity of the summed energy of detection; and generating an image of the cluster based on the determined cluster energy and the determined location of the cluster. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/905128 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/2955 (20130101) Original (OR) Class H01J 2237/2446 (20130101) H01J 2237/2803 (20130101) H01J 2237/24475 (20130101) H01J 2237/24495 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145719 | BRINDZA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jefferson Science Associates, LLC (Newport News, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PAUL DANIEL BRINDZA (NEWPORT NEWS, Virginia) |
| ABSTRACT | A self-supporting inorganic and radiation-hard neutron shielding panel for use in absorbing thermal neutrons. The panel is constructed substantially of concrete and includes a high level of boron by weight to enhance the absorption of thermal neutrons. A layer of radiation-resistant fiber reinforcement within the panel enables production of a thin, strong panel that is self-supporting and easily transportable. Mounting means are included on the panel to facilitate easy mounting on a wall or similar surface. The panels are constructed entirely of inorganic materials and include at least 58% boron by weight to maximize their effectiveness in shielding against thermal neutrons. Further disclosed are methods for forming the neutron-shielding panels. |
| FILED | Tuesday, December 17, 2019 |
| APPL NO | 17/769661 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 28/04 (20130101) C04B 2111/00862 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 1/12 (20130101) Original (OR) Class G21F 1/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145851 | Li |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Li (Tempe, Arizona) |
| ABSTRACT | A white organic light emitting device comprises a first emissive layer comprising a phosphorescent emitter; a second emissive layer comprising a fluorescent emitter; and an interface layer, disposed between the first emissive layer and the second emissive layer; wherein the interface layer comprises a high energy gap material represented by Formula I, Formula II, or Formula III. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054209 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/006 (20130101) H01L 51/42 (20130101) H01L 51/0052 (20130101) H01L 51/0054 (20130101) H01L 51/0059 (20130101) H01L 51/0061 (20130101) H01L 51/0067 (20130101) H01L 51/0072 (20130101) Original (OR) Class H01L 51/0073 (20130101) H01L 51/0074 (20130101) H01L 51/0084 (20130101) H01L 51/0087 (20130101) H01L 51/0094 (20130101) H01L 51/5016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146205 | Malzahn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua R. Malzahn (Salt Lake City, Utah); Eric G. Eddings (Salt Lake City, Utah) |
| ABSTRACT | Methods and systems for producing mesophasic (between liquid and solid phases) carbon materials from plastic waste. The method and system includes a 2-stage pyrolysis reactor, including first and second pyrolysis stages where a carbon feedstock material is subjected to pyrolysis. The first pyrolysis stage may subject the carbon feedstock material to pyrolysis at a first temperature in a range of 500° C. to 700° C., and the second pyrolysis stage may operate at a second temperature in a range of 800° C. to 1000° C., providing secondary gas phase reactions (SGR). A residence time of the carbon feedstock material in the reactor may be no more than 10 seconds. After pyrolysis and SGR, a sparging and thermal treatment stage may convert pyrolysis tar products to an anisotropic pitch product suitable for use in production of carbon fiber or bulk graphite for use in fabrication of graphite electrodes. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 17/981133 |
| CURRENT CPC | Destructive Distillation of Carbonageous Materials for Production of Gas, Coke, Tar, or Similar Materials C10B 53/07 (20130101) Original (OR) Class C10B 57/02 (20130101) C10B 57/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146249 | McKisson et al. |
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| FUNDED BY |
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| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (Newport News, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John E. McKisson (Williamsburg, Virginia); Brian Kross (Yorktown, Virginia); John McKisson (Yorktown, Virginia) |
| ABSTRACT | A subsurface continuous radioisotope environmental monitor that provides a continuous monitoring of the possible presence of radioactive species in subsurface groundwater. The detector and all supporting system elements are specifically constructed and equipped to be permanently mounted in a well or borehole to continuously detect and record radiation decay of radioactive species that are borne by subsurface water flow to that sampling area. The system operates by placing a detection element in a housing such that subsurface water that reaches the bore or well can flow in contact with the detection element. The system can employ several detection modes and materials. The detector includes SiPMs operating in a coincidence spectroscopy configuration to significantly reduce spurious signals due to thermal noise as well as increasing the total amount of signals collected. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977310 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/17 (20130101) G01T 1/201 (20130101) G01T 1/2006 (20130101) G01T 1/20185 (20200501) G01T 1/20188 (20200501) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/06 (20130101) Original (OR) Class G01V 5/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146527 | VILLA-ALEMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ELIEL VILLA-ALEMAN (AIKEN, South Carolina); MICHAEL C. MAXWELL (EVANS, Georgia); DON D. DICK, JR. (NORTH AUGUSTA, South Carolina) |
| ABSTRACT | Double-walled containment cells are described as may be used for storage, transport, and examination of a sample held within the cell by use of optical analysis techniques. A double-walled containment cell can include multiple types of windows that can be located as desired on the containment cells and thereby provide for optical access to a sample for multiple optical analysis techniques. Disclosed containment cells can be sized and designed for use with existing optical analysis systems, e.g., laser ablation, X-ray diffraction, spectral analysis (e.g., Raman spectroscopy, infrared spectroscopy, laser-induced breakdown spectroscopy, etc.), imaging analysis, etc. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523333 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/01 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146566 | Kassen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron G. Kassen (Sinking Spring, Pennsylvania); Iver E. Anderson (Ames, Iowa); Emma Marie Hamilton White (Des Moines, Iowa); Matthew J. Kramer (Ankeny, Iowa); David J. Byrd (Boone, Iowa); Liangfa Hu (Newark, California) |
| ABSTRACT | Improved manufacturing processes and resulting anisotropic permanent magnets, such as for example alnico permanent magnets, having highly controlled and aligned microstructure in the solid state are provided. A certain process embodiment involves applying a particular orientation and strength of magnetic field to loose, binder-coated magnet alloy powder particles in a compact-forming device as they are being formed into a compact in order to preferentially align the magnet alloy powder particles in the compact. The preferential alignment of the magnet alloy powder particle is locked in place in the compact by the binder after compact forming is complete. After removal from the device, the compact can be subjected to a subsequent sintering or other heat treating operation. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/803661 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/086 (20130101) Original (OR) Class H01F 7/021 (20130101) H01F 41/0273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146859 | Dai et al. |
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| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongtao Dai (West Hartford, Connecticut); Ram Ranjan (West Hartford, Connecticut); Robert H. Dold (Monson, Massachusetts) |
| ABSTRACT | A turbine rotor includes a base and a plurality of blades. A central nose is radially inward of the blades and defines an axis of rotation. A plurality of cooling manifolds is disposed within the turbine rotor and includes impingement cooling jets extending through a rear surface of the turbine rotor. An internal cooling manifold extends radially inward of the impingement cooling jets and extends between the base and the rear surface of the turbine rotor. A central nose cooling manifold extends into the central nose and is fluidically connected to the internal cooling manifold. A base cooling manifold is fluidically connected to the central nose manifold and extends radially outward from the central nose cooling manifold. A blade cooling manifold is fluidically connected to the base cooling manifold and extends within the blade. Trailing edge jets extend from the blade cooling manifold and through the trailing edge of blades. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/453804 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/046 (20130101) Original (OR) Class F01D 5/048 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/24 (20130101) F05D 2260/201 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147042 | STROBEL et al. |
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| FUNDED BY |
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| APPLICANT(S) | Carnegie Institution of Washington (Washington, District of Columbia) |
| ASSIGNEE(S) | Carnegie Institution of Washington (Washington, District of Columbia) |
| INVENTOR(S) | Timothy STROBEL (Washington, District of Columbia); Li ZHU (Washington, District of Columbia) |
| ABSTRACT | The present invention provides carbon-based clathrate compounds, including a carbon-based clathrate compound that includes a clathrate lattice with atoms of at least one element selected from the group consisting of carbon and boron as a host cage structure; guest atoms encapsulated within the clathrate lattice; and, substitution atoms that may be substituted for at least one portion of the carbon and boron atoms that constitute the clathrate lattice. In one embodiment, the invention provides a carbon-based clathrate compound of the formula LaB3C3. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/951939 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/30 (20200101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/38 (20130101) C01P 2006/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147086 | Saito et al. |
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| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tomonori Saito (Knoxville, Tennessee); Sungjin Kim (Knoxville, Tennessee); Md Anisur Rahman (Knoxville, Tennessee) |
| ABSTRACT | A crosslinked polymeric composition comprising a base polymer containing unconjugated carbon-carbon double bonds of the formula —CRa═CRb—, wherein a portion of said unconjugated carbon-carbon double bonds in said base polymer are interconnected by a crosslinker (L) as shown in the following structure: wherein: Ra and Rb are independently selected from hydrogen atom and hydrocarbon groups, wherein Ra and Rb may optionally interconnect to form a ring; x represents the molar percentage of segments that are linked with the linker L throughout the crosslinked polymeric composition; L is a crosslinker having the formula: —S—R1-La-R2-Lb-R1—S—; R1 and R2 are independently selected from hydrocarbon linking groups containing at least one carbon atom; La and Lb independently represent dynamic reversible crosslinking groups; and Za and Zb independently represent remaining portions of the base polymer. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/982953 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) Original (OR) Class C08J 2353/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147320 | Knowlton |
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| FUNDED BY |
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| APPLICANT(S) | Boise State University (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William B. Knowlton (Boise, Idaho) |
| ABSTRACT | Using nucleotide architectures to very closely and precisely place chromophores on a nucleic acid template to form dye aggregates that produce quantum coherent excitons, biexcitons, and triexcitons upon excitement to create excitonic quantum wires, switching, and gates that would then form the basis of quantum computation. Creating the various excitons and controlling the timing of the excitons would be performed using light of the corresponding wavelength and polarization to stimulate the corresponding chromophores. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/249159 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Original (OR) Class Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 11/08 (20130101) C09B 23/06 (20130101) C09B 23/083 (20130101) Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147503 | Analytis et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | James G. Analytis (Berkeley, California); Shannon C. Haley (Oakland, California); Eran Maniv (Ramat Raziel, Israel) |
| ABSTRACT | Switchable antiferromagnetic (AFM) memory devices are provided based on an active material, FexNbS2, where x>1/3 and FexNbS2 where x<1/3, that exhibits the ability to manipulate spin information “non-locally” i.e. tens of microns away from the electrical stimulus. Spin information can be transported and stored non-locally in the FexNbS2 material. The devices leverage two long range effects: collective excitations to carry spin and strong magnetoelastic coupling to allow complex domain structures to propagate over large distances. The application of current pulses across the material can rotate or switch the AFM order between multiple directions. Non-local resistance measurements can detect the orientation of the AFM order as high or low resistance states. The state of the device can be set by input current pulses, and read-out by the resistance measurement, forming a non-volatile, AFM memory storage bit. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054318 |
| CURRENT CPC | Static Stores G11C 11/161 (20130101) Original (OR) Class G11C 11/1673 (20130101) G11C 11/1675 (20130101) Electric solid-state devices not otherwise provided for H10N 50/20 (20230201) H10N 50/85 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147819 | DALMASO et al. |
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| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MICHAEL J. DALMASO (MARTINEZ, Georgia); DANIEL KREMENTZ (AUGUSTA, Georgia); RICHARD E. KOENIG, II (EVANS, South Carolina) |
| ABSTRACT | A tamper-indicating assembly for a drum enclosure assembly is provided. The tamper-indicating assembly includes a tamper-indicating device that defines a cavity sized to receive and surround at least a portion of the closure bolt, the first flanged end, and the second flanged end to prevent movement of the closure bolt. A tab extends radially outward from the tamper-indicating device with respect to an axial centerline of the tamper-indicating assembly. The tamper-indicating assembly further includes a pin non-removably coupled to the tamper-indicating device. The pin extends through the tamper-indicating device and across the cavity such that the tamper-indicating device and the pin collectively surround the closure bolt. The exemplary tamper-indicating device described herein includes features that facilitate the robotic application of the tamper-indicating device to a drum enclosure. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524035 |
| CURRENT CPC | Machines, Apparatus or Devices For, or Methods Of, Packaging Articles or Materials; Unpacking B65B 7/2842 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 7/045 (20130101) B65D 45/322 (20130101) B65D 55/02 (20130101) Original (OR) Class Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 5/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230141247 | Bottiglio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca Bottiglio (Hamden, Connecticut); Shanliangzi Liu (New Haven, Connecticut); Dylan Shah (New Haven, Connecticut); Lina Mercedes Sanchez Botero (New Haven, Connecticut) |
| ABSTRACT | Provided are biphasic compositions including a quantity of a conductive liquid and a plurality of a particulate suspended in the quantity of conductive liquid, wherein there is sufficient wetting between the solid particles and the conductive liquid and wherein the resistance of the compositions are less than the resistance for a bulk conductor when strained as defined by Pouillet's law. Also provided are stretchable circuit board assemblies including the biphasic compositions and methods of using the stretchable circuit board assemblies including the biphasic compositions. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/148500 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/18 (20130101) H05K 1/092 (20130101) H05K 1/115 (20130101) H05K 1/0283 (20130101) Original (OR) Class H05K 3/284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142139 | Stanley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George Geoffrey Stanley (Baton Rouge, Louisiana); Drew Michael Hood (Baton Rouge, Louisiana) |
| ABSTRACT | Disclosed are highly active cationic cobalt phosphine complexes, both mono- and bimetallic, that can catalyze hydroformylation reactions. The disclosed catalysts can be utilized in methods that provide reaction processes that are hundreds of times faster than high pressure HCo(CO)4 or phosphine-modified HCo(CO)3(PR3) catalysts and operate at considerably lower pressures and temperatures. Also disclosed are methods of hydroformylation using the described transition metal complexes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089365 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2409 (20130101) Original (OR) Class B01J 2231/321 (20130101) B01J 2531/0216 (20130101) B01J 2531/845 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142369 | Hsu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Po-Chun Hsu (Durham, North Carolina); Xiuqiang Li (Durham, North Carolina); Boran Ma (Durham, North Carolina); Catherine Brinson (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes a multimodal adaptive textile with moisture-responsive flaps composed of a nylon/metal heterostructure, which can simultaneously regulate convection, sweat evaporation, and mid-infrared emission to accomplish heat transfer tuning in response to human perspiration vapor. A metal layer contributes to low-emissivity radiative heating and enhances the bimorph actuation performance. The multimodal adaptive mechanism expands the thermal comfort zone compared to traditional static textiles and single-modal adaptive textiles without any electricity or energy input. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 18/054640 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/002 (20130101) A41D 27/28 (20130101) Original (OR) Class A41D 31/12 (20190201) A41D 31/065 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142611 | Zhan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jixun Zhan (North Logan, Utah) |
| ASSIGNEE(S) | UTAH STATE UNIVERSITY (Logan, Utah) |
| INVENTOR(S) | Jixun Zhan (North Logan, Utah) |
| ABSTRACT | The present invention relates to an in vitro or in vivo process for producing a glucuronide comprising a glucuronic acid moiety bound to a phenolic hydroxyl group or a phenolic carboxyl group. Also provided are expression vectors, nucleic acids, polypeptides, and recombinant microbial cells useful in carrying out the process and prodrugs produced by the process. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/822733 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/1051 (20130101) C12N 9/1241 (20130101) C12N 15/62 (20130101) C12N 15/63 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/60 (20130101) Original (OR) Class Enzymes C12Y 101/01022 (20130101) C12Y 204/01017 (20130101) C12Y 207/07009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142846 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Kyle Christopher Smith (Champaign, Illinois); Erik Richard Reale (Martinez, California); Irwin Cunnie Loud, IV (Oak Park, Illinois); Vu Quoc Do (Urbana, Illinois) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, a porous electrode that includes a porous layer, and a pattern of flow channels defined in the porous layer, wherein a first flow channel in the pattern of flow channels has a shape that at least partially approximates a cube-root profile. Additional embodiments are disclosed. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980017 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/861 (20130101) H01M 4/8626 (20130101) H01M 8/188 (20130101) Original (OR) Class H01M 8/04432 (20130101) H01M 8/04783 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230142881 | RINALDI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matteo RINALDI (Boston, Massachusetts); Flavius POP (Boston, Massachusetts); Bernard HERRERA (Cambridge, Massachusetts) |
| ABSTRACT | Devices for ultrasonic transmission and/or reception having a piezoelectric micromachined ultrasonic transducer (pMUT). The device employs a material such as lithium niobate as a piezoelectric layer in a membrane suspended over a cavity. Two activation electrodes on an upper surface of the membrane can activate one or more flexural modes of mechanical vibration in the membrane, the flexural modes of vibration including a displacement in a cross-sectional plane of the membrane. The device can be used individually or in an array. The device can be configured for use in a liquid medium or in biological tissue. A method of operating an ultrasonic transducer is provided. A method of fabrication of an ultrasonic transducer is provided. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/986280 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0021 (20130101) Original (OR) Class B81B 2201/0271 (20130101) B81B 2203/04 (20130101) B81B 2203/0127 (20130101) B81B 2203/0315 (20130101) B81B 2207/053 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/1138 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143048 | Larson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natalie M. Larson (Cambridge, Massachusetts); Jochen Mueller (Baltimore, Maryland); Jennifer A. Lewis (Cambridge, Massachusetts) |
| ABSTRACT | A printhead comprises a plurality of ink cartridges and a nozzle, where the nozzle and the ink cartridges are configured to rotate together about an axis during printing. The nozzle includes a nozzle body comprising an inlet end, an outlet end, and one or more internal passageways extending through the nozzle body from the inlet end to the outlet end. The one or more internal passageways terminate at one or more outlets at or near the outlet end. The nozzle also includes plurality of nozzle inlets at the inlet end for delivery of flowable inks into the internal passageways, where each nozzle inlet is in fluid communication with a dispensing end of one of the ink cartridges. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/982877 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/255 (20170801) B29C 64/264 (20170801) B29C 64/336 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230144336 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joshua R. Smith (Seattle, Washington); Xingyi Shi (Seattle, Washington) |
| ABSTRACT | Examples of charging systems are described which may utilize a network of resonator circuits. Control methods are described which may locate a charging location at which an electronic device is placed proximate the charging system and identify a path of resonator circuits to activate to charge the electronic device. Individual resonator circuits in the path may be activated by selecting a resonant frequency of the resonator circuit such that power may be transferred by the resonator circuit at an operating frequency. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/905163 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0063 (20130101) H02J 7/342 (20200101) H02J 50/005 (20200101) H02J 50/12 (20160201) H02J 50/80 (20160201) H02J 50/502 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145232 | CHAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhimin CHAI (Revere, Massachusetts); Adnan KORKMAZ (Edison, New Jersey); Cihan YILMAZ (Campbell, California); Ahmed A. BUSNAINA (Needham, Massachusetts) |
| ABSTRACT | Interfacial convective assembly can assemble any type of nanoparticles or other nanoelements in minutes to form microscale and nanoscale patterns in vias or trenches in patterned substrates. The nanoelements can be assembled on both hydrophilic and hydrophobic surfaces. Nanoparticles can fuse during the process to provide solid or single crystalline electrical circuit components. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/918211 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00063 (20130101) B81C 1/00373 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145742 | Ellison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Christopher J. Ellison (Eden Prairie, Minnesota); Timothy M. Kowalewski (St. Paul, Minnesota); Lorraine F. Francis (Minnetonka, Minnesota); Matthew M. Hausladen (Minneapolis, Minnesota); Boran Zhao (Minneapolis, Minnesota); Matthew Kubala (Minneapolis, Minnesota) |
| ABSTRACT | Some aspects of the present disclosure relate to systems and methods for polymer-based extrusion. Some non-limiting embodiments provide for extrusion of a liquid photopolymerizable monomer in a channel/die with the aid of a lubricating component, such as poly(dimethylsiloxane)-graft-poly(ethylene oxide) grafted copolymer (PDMS-PEO), and driven by fluid pressure (e.g., a fluid pump). Other aspects of the present disclosure relate to growing soft robots. Some non-limiting embodiments provide a novel class of robots which grow in an environment by growing at their tip (or robot head) by using the self-lubricated photopolymerization extrusion techniques of the present disclosure. Emulating biological tip growth, this process is facilitated by converting an internal monomer fluid into the solid body of the growing robot through polymerization. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 17/985488 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 18/02 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/09 (20190201) B29C 48/91 (20190201) B29C 48/94 (20190201) B29C 2948/92066 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146427 | Schiros et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Theanne SCHIROS (New York, New York); Helen H. LU (New York, New York); Romare M. ANTROBUS (New York, New York); Christan JOSEPH (New York, New York); Adrian M. CHITU (New York, New York); Shanece ESDAILLE (New York, New York); Susanne GOETZ (New York, New York); Anne VERPLOEGH CHASSÉ (New York, New York); ESPOSITO DANIELLA (New York, New York); Arianna WONG (New York, New York); Dylon SHEPELSKY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theanne Schiros (New York, New York); Helen H. Lu (New York, New York); Romare M. Antrobus (New York, New York); Christian Joseph (New York, New York); Adrian M. Chitu (New York, New York); Shanece Esdaille (New York, New York); Susanne Goetz (New York, New York); Anne Marika Verploegh Chassé (New York, New York); Daniella Esposito (New York, New York); Arianna Wong (New York, New York); Dylon Shepelsky (New York, New York) |
| ABSTRACT | A biomaterial may be produced by employing bacterial nanocellulose which are biologically functional and can be enhanced via an enzyme tanning treatment, to form a functional biotextile that has improved functionality and various desirable and/or enhanced properties. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/793030 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 16/003 (20130101) Original (OR) Class D06M 2101/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146689 | REDA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sherief REDA (Barrington, Rhode Island); Hokchhay TANN (North Reading, Massachusetts); Soheil HASHEMI (Boston, Massachusetts); R. Iris BAHAR (Providence, Rhode Island) |
| ABSTRACT | A hardware neural network system includes an input buffer for input neurons (Nbin), an output buffer for output neurons (Nbout), and a third buffer for synaptic weights (SB) connected to a Neural Functional Unit (NFU) and a control logic (CP) for performing synapses and neurons computations. The NFU pipelines a computation into stages, the stages including weight blocks (WB), an adder tree, and a non-linearity function. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/061884 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Original (OR) Class G06N 3/084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146821 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Evan R. Daugharthy (Cambridge, Massachusetts); Richard C. Terry (Carlisle, Massachusetts) |
| ABSTRACT | The present disclosure provides methods that combine RNA fluorescent in situ sequencing (FISSEQ) with other molecular detection modalities, forming an integrated panomic detection platform. In various embodiments, the present disclosure provides systems and methods to prepare a biological sample to preserve the spatial relationships of biomolecules of interest within the biological sample for FISSEQ detection. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/884808 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) A61L 2400/16 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 2300/0636 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6834 (20130101) C12Q 1/6874 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147004 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alexander Green (Chestnut Hill, Massachusetts); Duo Ma (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Green (Chestnut Hill, Massachusetts); Duo Ma (Tempe, Arizona) |
| ABSTRACT | The present invention provides loop-mediated riboregulators for the detection of SARS-CoV-2. Also provided are DNA constructs encoding the loop-mediated riboregulators and methods of using the loop-mediated riboregulators to detect the presence of SARS-CoV-2 in a sample. |
| FILED | Thursday, August 25, 2022 |
| APPL NO | 17/822213 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147113 | Varnavski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oleg Varnavski (Ann Arbor, Michigan); Theodore Goodson, III (Ann Arbor, Michigan) |
| ABSTRACT | The present disclosure pertains to two-photon microscopy, and specifically to methods and systems for optimizing the performance of entangled two-photon absorption (ETPA) microscopy. An ETPA microscope is described with time delay tunability to optimize the coincidence of entangled photons on a sample. The optimization allows for increased two-photon absorption by the sample, resulting in increased luminescence of the sample. The ETPA microscopy systems and methods described allow for nonlinear imaging using excitation energy intensities six orders of magnitude lower than comparable two-photon absorption microscopy techniques using classical light. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/802607 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230147365 | Cui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Honggang Cui (Baltimore, Maryland); Charles Williams Flexner (Baltimore, Maryland); Maya Monroe (Baltimore, Maryland); Han Wang (Baltimore, Maryland) |
| ABSTRACT | Disclosed are therapeutic self-assembling molecules including a peptide sequence conjugated to one or more antiviral therapeutics to form a peptide-based antiviral prodrug capable of self-assembly into supramolecular structures with varying morphology in aqueous solutions, which can be injected subcutaneously or intramuscularly for the long-acting treatment of chronic viral infections. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/981595 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 31/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230141247 | Bottiglio et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca Bottiglio (Hamden, Connecticut); Shanliangzi Liu (New Haven, Connecticut); Dylan Shah (New Haven, Connecticut); Lina Mercedes Sanchez Botero (New Haven, Connecticut) |
| ABSTRACT | Provided are biphasic compositions including a quantity of a conductive liquid and a plurality of a particulate suspended in the quantity of conductive liquid, wherein there is sufficient wetting between the solid particles and the conductive liquid and wherein the resistance of the compositions are less than the resistance for a bulk conductor when strained as defined by Pouillet's law. Also provided are stretchable circuit board assemblies including the biphasic compositions and methods of using the stretchable circuit board assemblies including the biphasic compositions. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/148500 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/18 (20130101) H05K 1/092 (20130101) H05K 1/115 (20130101) H05K 1/0283 (20130101) Original (OR) Class H05K 3/284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230143154 | Priedeman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Lake Priedeman (Northport, Alabama); Gregory Bruce Thompson (Tuscaloosa, Alabama) |
| ABSTRACT | Various implementations include a device for deposition of conformal coatings. The device includes a powder container, a connecting rod, and a crankshaft. The powder container has a first side configured to contain a powder and a second side. The connecting rod has a first end directly hingedly coupled to the second side of the powder container and a second end. The crankshaft has a longitudinal axis, a main shaft portion extending along the longitudinal axis, and a cam portion radially offset from and rotatable about the longitudinal axis. The second end of the connecting rod is directly rotatably coupled to the cam portion. Rotation of the crankshaft about the longitudinal axis causes the second end of the connecting rod to rotate about the longitudinal axis, causing the powder container to linearly oscillate between a first position and a second position. |
| FILED | Wednesday, November 02, 2022 |
| APPL NO | 17/979392 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/16 (20130101) Original (OR) Class C23C 14/28 (20130101) C23C 14/35 (20130101) C23C 14/3407 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 3/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146048 | Jones et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Todd J. Jones (Altadena, California); Shouleh Nikzad (Valencia, California) |
| ABSTRACT | A detector including a detector membrane comprising a semiconductor sensor and a readout circuit, the detector membrane having a thickness of 100 micrometers or less and a curved surface conformed to a curved focal plane of an optical system imaging electromagnetic radiation onto the curved surface; and a mount attached to a backside of the detector membrane. A maximum of the strain experienced by the detector membrane is reduced by distribution of the strain induced by formation of the curved surface across all of the curved surface of the detector membrane, thereby allowing an increased radius of curvature of the curved surface as compared to without the distribution. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/955679 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14683 (20130101) H01L 27/14875 (20130101) Original (OR) Class H01L 31/03926 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146689 | REDA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sherief REDA (Barrington, Rhode Island); Hokchhay TANN (North Reading, Massachusetts); Soheil HASHEMI (Boston, Massachusetts); R. Iris BAHAR (Providence, Rhode Island) |
| ABSTRACT | A hardware neural network system includes an input buffer for input neurons (Nbin), an output buffer for output neurons (Nbout), and a third buffer for synaptic weights (SB) connected to a Neural Functional Unit (NFU) and a control logic (CP) for performing synapses and neurons computations. The NFU pipelines a computation into stages, the stages including weight blocks (WB), an adder tree, and a non-linearity function. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/061884 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Original (OR) Class G06N 3/084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230140941 | Fletcher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Fletcher (Baltimore, Maryland); Alexander MacKerell (Baltimore, Maryland); Paul Shapiro (Baltimore, Maryland); Jeffrey Hasday (Timonium, Maryland) |
| ABSTRACT | Compounds that inhibit p38a MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/906254 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/61 (20130101) C07D 215/14 (20130101) C07D 295/135 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230145832 | Marasco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul D. Marasco (Lakewood, Ohio); Jonathon S. Schofield (Davis, California); Courtney E. Shell (Round Rock, Texas); Zachary C. Thumser (Cleveland, Ohio); Dylan Beckler (Lyndhurst, Ohio); Jonathan Sakai (Rocky River, Ohio) |
| ABSTRACT | A cognitive illusion of ownership over a proxy extremity (e.g. a hand) is provided by discordant touch and visual information to a user. While the user feels the touch on their real extremity, they see a corresponding touch on the proxy extremity. The user's internally modeled reality is then updated to move the felt location of the real extremity to the seen location of the proxy extremity. As a result, the user embodies the proxy extremity, thereby disembodying the real extremity. Pain associated with medical procedures performed on the real extremity is then mitigated. And because an epileptic brain is less stringent when resolving conflict between what is seen and what is felt, correlations in time or space can shift attribution of the sensation of the felt touch on the user's real extremity to the location of the proxy extremity. This can be helpful in treating and/or diagnosing epilepsy. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980164 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/52 (20130101) A61M 21/02 (20130101) Original (OR) Class A61M 2021/0022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230142910 | Bassaganya-Riera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Landos Biopharma, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | Landos Biopharma, Inc. (Blacksburg, Virginia) |
| INVENTOR(S) | Josep Bassaganya-Riera (Blacksburg, Virginia); Adria Carbo Barrios (Blacksburg, Virginia); Richard Gandour (Blacksburg, Virginia); Julian D. Cooper (Blacksburg, Virginia); Raquel Hontecillas (Blacksburg, Virginia) |
| ABSTRACT | Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/085018 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4439 (20130101) Acyclic or Carbocyclic Compounds C07C 65/40 (20130101) Heterocyclic Compounds C07D 213/69 (20130101) C07D 213/79 (20130101) C07D 307/60 (20130101) C07D 307/68 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230146098 | Tuncdemir et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Safakcan Tuncdemir (Linden, Pennsylvania); Joshua Gambal (Linden, Pennsylvania); Gareth Knowles (Linden, Pennsylvania) |
| ASSIGNEE(S) | QorTek, Inc. (Linden, Pennsylvania) |
| INVENTOR(S) | Safakcan Tuncdemir (Linden, Pennsylvania); Joshua Gambal (Linden, Pennsylvania); Gareth Knowles (Linden, Pennsylvania) |
| ABSTRACT | A semi-wave transducer is provided that comprises a circular or elliptic transduction shell that has sidewalls captured between identical opposing upper and lower circular or elliptic conical segments (platens), each having a surface geometry of a radially symmetric wave shape that includes a center region and a rim wherein the distance between the center region of the upper and lower platens greater than the distance between the rims of the upper and lower platens. In some embodiments, the surface geometry of the platens may be a jinc function or a recurve function. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/911945 |
| CURRENT CPC | Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 9/22 (20130101) G10K 9/121 (20130101) Original (OR) Class Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230142090 | Bosire et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (lthaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erick Maosa Bosire (Ithaca, New York); Craig Altier (Freeville, New York) |
| ABSTRACT | Disclosed herein is a method for inhibiting or preventing Vibrio cholera toxin production in a subject, the method comprising enterally administering to the subject a pharmaceutically effective amount of a fatty acid dissolved or suspended in a pharmaceutically acceptable carrier, wherein the fatty acid contains 10 to 30 carbon atoms, such as an unsaturated fatty acid such as a cis-2-unsaturated fatty acid, such as a fatty acid having the formula: wherein n is an integer of 6-26, and the fatty acid optionally includes a second carbon-carbon double bond resulting from removal of two hydrogen atoms on adjacent carbon atoms. Also disclosed herein is a method for treating or preventing a Vibrio infection comprising administering to a subject in need of treatment an effective amount of a genetically engineered bacterium, wherein the genetically engineered bacterium comprises an exogenous nucleic acid encoding an enzyme that produces a diffusible signal factor (DSF) by introducing a cis-2 double bond to a fatty acid. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/916368 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/201 (20130101) Original (OR) Class A61K 35/745 (20130101) A61K 35/747 (20130101) A61K 47/10 (20130101) A61K 47/20 (20130101) A61K 47/44 (20130101) A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Enzymes C12Y 503/03013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230145015 | Hammig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Hammig (Dexter, Michigan); Nicholas Kotov (Ann Arbor, Michigan) |
| ABSTRACT | A detector includes a substrate including a matrix of aramid nanofibers, a distribution of nanoparticles across the matrix of aramid nanofibers, and a plurality of organic capping ligands. Each organic capping ligand of the plurality of organic capping ligands bonds a respective nanoparticle of the plurality of nanoparticles to a respective aramid nanofiber of the matrix of aramid nanofibers. The detector further includes first and second electrodes disposed along opposite sides of the substrate to capture charges generated by photons or particles incident upon the detector. Each nanoparticle of the plurality of nanoparticles has a semiconductor composition. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/912834 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/366 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/085 (20130101) Original (OR) Class H01L 31/0224 (20130101) H01L 31/0384 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20230147640 | RIVERA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELYSIUM ROBOTICS LLC (Cedar Park, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rodrigo Alvarez-Icara RIVERA (Cedar Park, Texas) |
| ABSTRACT | Disclosed herein are methods and systems for making DEMAs by forming a mechanical and electrical connection between a bundle of dielectric elastomer microfibers comprising a direct mechanical connection between the face of each microfiber and a supportive element, and a direct electrical connection between the core of all microfibers and a metallic contact. Also disclosed are dielectric elastomer (DE) microfibers comprised of an inner electrode, a hollow tube, and an outer electrode, wherein the ratio alpha between the outer and inner diameter maximizes the electromechanical performance of such fiber as an actuator. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/995353 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/12 (20130101) B25J 9/1075 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20230141697 | Chu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Hetao Chu (Chengdu, China PRC); Jinsong Leng (Harbin, China PRC); Ray H. Baughman (Dallas, Texas); Xinghao Hu (Plano, Texas); Na Li (Milwaukee, None); Carter S. Haines (Murphy, Texas); Shaoli Fang (Richardson, Texas); Zhong Wang (Dallas, Texas); Mu Jiuke (Plano, Texas) |
| ABSTRACT | Previous electrochemically-powered yarn muscles cannot be usefully operated between extreme negative and extreme positive potentials, since strokes during electron injection and during hole injection partially cancel because they are in the same direction. Unipolar-stroke carbon nanotube yarn muscles are described in which muscle strokes are additive between extreme negative and extreme positive potentials, and stroke increases with potential scan rate. These electrochemical artificial muscles include an electrically conducting twisted or coiled yarn and a material that dramatically shifts the potential of zero charge of the electrochemically actuated yarn. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 17/380746 |
| CURRENT CPC | Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/16 (20130101) D02G 3/26 (20130101) D02G 3/441 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2401/16 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/012 (20210801) F03G 7/025 (20210801) Original (OR) Class F03G 7/029 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20230145418 | Whiteley |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Whiteley (Sunnyvale, California) |
| ABSTRACT | The present disclosure relates to improved electronic structures for propagating logic states between superconducting digital logic gates using a three-junction interferometer in a receiver circuit to reduce reflecting signals that otherwise result in distortions in the signals being transmitted between the gates. Other improved electronic structures comprise passive transmission lines (PTLs) with transmission line matching circuitry that has previously been avoided. The matching circuity minimizes generation and propagation of spurious pulses emitted by Josephson junctions used in the digital logic gates. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181869 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/035 (20130101) Original (OR) Class Pulse Technique H03K 19/195 (20130101) Electric solid-state devices not otherwise provided for H10N 60/12 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230143826 | Turner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alison Frankowski Turner (Arlington, Virginia); Marc D. McCrery (Arlington, Virginia); James J. Boldt (Leesburg, Virginia) |
| ABSTRACT | A system and method of augmenting a delivery route. Exemplary methods include first location information from a first position device and receiving second location information from a second position device, storing first and second location information, and determining, based on at least one of the first and second information, a time and a location for each of a plurality of stops. Exemplary methods also include reconciling determined time and locations of each of the plurality of stops with a stored route, the stops having a stored location and a stored time associated therewith and estimating a plurality of transition times between pairs of the plurality of stops. Exemplary methods include constructing an updated timeline based on the plurality of stored stops, the plurality of determined stops, and the plurality of transition times and updating the delivery route based on the constructed timeline. |
| FILED | Monday, January 02, 2023 |
| APPL NO | 18/149146 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 50/045 (20130101) B60W 2050/046 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3492 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/047 (20130101) G06Q 10/08355 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230148411 | Amari |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Martin Richard Amari (Glastonbury, Connecticut) |
| ABSTRACT | A system for bleeding air from a core flow path of a gas turbine engine is disclosed. In various embodiments, the system includes a bleed valve having a bleed valve inlet configured to receive a bleed air from a first access point to the core flow path and a bleed valve outlet; and an air motor having a first air motor inlet configured to receive the bleed air from the bleed valve outlet and a first air motor outlet configured to exhaust the bleed air, the air motor configured to pump the bleed air from the core flow path of the gas turbine engine. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893640 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/27 (20130101) F02C 9/18 (20130101) Original (OR) Class Non-positive-displacement Pumps F04D 27/0207 (20130101) F04D 27/0215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, May 11, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230511.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page