FedInvent™ Patent Applications
Application Details for Thursday, May 18, 2023
This page was updated on Friday, May 26, 2023 at 02:43 AM GMT
Department of Health and Human Services (HHS)
20230148587 — PRESERVATION OF NATURAL AND BIOENGINEERED TISSUES AND METHODS OF STORING AND TRANSPORT
| US 20230148587 | CAMPBELL et al. |
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| FUNDED BY |
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| APPLICANT(S) | TISSUE TESTING TECHNOLOGIES LLC (North Charleston, South Carolina) |
| ASSIGNEE(S) | TISSUE TESTING TECHNOLOGIES LLC (North Charleston, South Carolina) |
| INVENTOR(S) | Lia H. CAMPBELL (Mount Pleasant, South Carolina); Kelvin G.M. BROCKBANK (CHARLESTON, South Carolina) |
| ABSTRACT | Described herein are methods for preserving biomaterials by vitrification while reducing or preventing the loss of viability associated with conventional preservation methods. Also described herein are cassettes and methods for using these cassettes for cryopreserving biomaterials (e.g., a bioengineered construct or natural tissue sample). |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/987404 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148852 | Liang |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rongguang Liang (Tucson, Arizona) |
| ABSTRACT | Systems, devices and methods for imaging hard-to-view and hard-to-reach places in the oral cavity, such as at the base of the tongue and tonsillar regions, are described. An example mobile intraoral imaging system includes a white light source and a blue or ultraviolet light source for illuminating a region in the oral cavity. The system includes a mobile device configured to receive information associated with reflected and autofluorescent light from the region in the oral cavity, as well as a semi-flexible probe that includes a bendable tip; the probe is changeable in shape to allow insertion in the oral cavity and includes a camera that is positioned at a section of its tip to capture the reflected and autofluorescent light. The system enables quick acquisition of high-quality images, and allows remote imaging and diagnosis of suspicious lesions in the oral cavity. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/995595 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/24 (20130101) Original (OR) Class A61B 1/043 (20130101) A61B 1/00096 (20130101) A61B 1/0646 (20130101) A61B 1/0661 (20130101) A61B 5/0071 (20130101) A61B 5/0088 (20130101) A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148909 | Bijan |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Najafi Bijan (Houston, Texas) |
| ABSTRACT | A system for patient activity monitoring may include a wearable device and a personal terminal. The personal terminal may include a processor. The processor of the personal terminal may be configured to receive, from the wearable device, proximity detection information specifying proximity detected by the wearable device between the wearable device and a tag device and sensor data received by the wearable device from the tag device. The processor of the personal terminal may be further configured to determine, based on the proximity detection information and the sensor data, that an action was performed by a patient. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/995540 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/746 (20130101) A61B 5/1112 (20130101) A61B 5/1113 (20130101) Original (OR) Class A61B 5/4088 (20130101) A61B 5/6801 (20130101) A61B 2562/0219 (20130101) A61B 2562/0257 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148951 | Thatcher et al. |
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| FUNDED BY |
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| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey E. Thatcher (Irving, Texas); Wensheng Fan (Plano, Texas); Kevin Plant (Richardson, Texas); Faliu Yi (Allen, Texas) |
| ABSTRACT | The present disclosure relates to systems and methods for assessing or predicting the status of wounds such as burns. Systems can include at least one light detection element and one or more processors configured to receive a signal from the at least one light detection element representing light reflected from a tissue region, generate an image having a plurality of pixels depicting the tissue region, and determine a burn status of a subset of pixels of the image using one or more deep learning algorithms. Systems can further be configured to generate a classified image of the tissue region and/or determine a predictive score associated with healing of the wound. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152654 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/445 (20130101) Original (OR) Class A61B 5/4842 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20084 (20130101) G06T 2207/30088 (20130101) G06T 2207/30101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149000 | MILNER et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Thomas E. MILNER (Austin, Texas); Jason B. KING (Austin, Texas); Nitesh KATTA (Austin, Texas); James W. TUNNELL (Austin, Texas) |
| ABSTRACT | Apparatus and methods for tissue excision. In certain aspects, the apparatus and methods include an annular converging laser beam. The annular converging laser beam can be directed to a surface of a tissue and displace a portion of the tissue in a single or multiple laser pulses. In particular aspects, the dosimetry of the laser beam (e.g. the beam shape, pulse energy and pulse duration) can be controlled to eject the portion of the tissue in a manner to reduce damage to the displaced tissue and the surrounding tissue. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/995865 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/02 (20130101) Original (OR) Class A61B 18/22 (20130101) A61B 2018/00761 (20130101) A61B 2018/2205 (20130101) A61B 2018/2266 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149089 | TRAYANOVA et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Natalia A. TRAYANOVA (Baltimore, Maryland); Eric SUNG (Baltimore, Maryland); Adityo PRAKOSA (Baltimore, Maryland); Shijie ZHOU (Baltimore, Maryland) |
| ABSTRACT | A method for guiding ablation of atrial or ventricular arrhythmia in a patient's heart is provided. A digital representation of the electrical functioning of atria or ventricles of the patient's heart is generated based on imaging data of the patient's heart that reveals the presence of adipose tissue. The arrhythmias arising in the presence of the adipose tissue in the digital representation of the patients atria or ventricles are determined. The method further includes identifying, in the digital representation, ablation targets that need to be ablated to terminate determined arrhythmias; executing, in the digital representation, a mock-up of a clinical ablation procedure of the patient to determine the electrical response of the patients heart to ablating the ablation targets, and to determine whether the heart continues to generate new arrhythmias post-procedure; and generating a final set of ablation targets based on the mock-up of the clinical ablation procedure. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/995148 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1477 (20130101) A61B 34/10 (20160201) Original (OR) Class A61B 2018/00577 (20130101) A61B 2034/104 (20160201) A61B 2034/105 (20160201) A61B 2034/107 (20160201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149216 | Knox et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne Knox (Rochester, New York); Jonathan D. Ellis (Tucson, Arizona); Krystel R. Huxlin (Rush, New York); Daniel R. Brooks (Rochester, New York); Kaitlin T. Wozniak (Rochester, New York) |
| ABSTRACT | Refractive index writing system and methods employing a pulsed laser source for providing a pulsed laser output at a first wavelength; an objective lens for focusing the pulsed laser output to a focal spot in an optical material; a scanner for relatively moving the focal spot with respect to the optical material at a relative speed and direction along a scan region for writing one or more traces in the optical material defined by a change in refractive index; and a controller for controlling laser exposures along the one or more traces in accordance with a calibration function for the optical material to achieve a desired refractive index profile in the optical material. The refractive index writing system may be for writing traces in in vivo optical tissue, and the controller may be configured with a calibration function obtained by calibrating refractive index change induced in enucleated ocular globes. A real-time process control monitor for detecting emissions from the optical material transmitted through the objective lens at a second wavelength may further be employed while writing the one or more traces. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099402 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00804 (20130101) A61F 9/00827 (20130101) Original (OR) Class A61F 2009/00855 (20130101) A61F 2009/00897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149295 | McKEON et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas); The Board of Regents of The University of Texas System (Austin, Texas); Tract Pharmaceuticals, Inc. (West Hartford, Connecticut) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); The Board of Regents of The University of Texas System (Austin, Texas); Tract Pharmaceuticals, Inc. (West Hartford, Connecticut) |
| INVENTOR(S) | Frank McKEON (Houston, Texas); Rahul NEUPANE (Houston, Texas); Jingzhong XIE (Houston, Texas); Wa XIAN (Houston, Texas); Matthew VINCENT (West Hartford, Connecticut); Shan WANG (Houston, Texas) |
| ABSTRACT | The present disclosure addresses IBD from the standpoint of inhibiting or ablating pathogenic mucosal stem cells cloned from defined regions of disease in the gastrointestinal tract. In the case of Crohn's disease, for example, isolation of those stem cells according to the methods of the present disclosure reveals a pattern of inflammatory gene expression in stem cells from the terminal ileum and colon that is epigenetically maintained despite months of continuous cultivation in the absence of immune or stromal cells, or of intestinal microbes. Superimposed on this distributed inflammatory phenotype is a differentiation defect that profoundly and specifically alters the mucosal barrier properties of the terminal ileum. The co-existence of diseased and normal stem cells within the same endoscopic biopsies of Crohn's disease patients implicates an epigenetically enforced heterogeneity among mucosal stem cells in the dynamics of this condition. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/906027 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149307 | BAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (Montréal, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guangyu BAO (Montréal, Canada); Jianyu LI (Verdun, Canada); Luc MONGEAU (Mont Royal, Canada); Sareh TAHERI (Montréal, Canada); Sepideh MOHAMMADI (Montréal, Canada) |
| ABSTRACT | There is provided a porous double-network hydrogel comprising: a first network comprising a first polymer; a second network comprising a second polymer. The porous double-network hydrogel comprises pores having a diameter of at least 1 μm, and the porous double-network hydrogel is perfusable and injectable. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054292 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) Original (OR) Class A61K 9/0019 (20130101) A61K 35/36 (20130101) A61K 47/32 (20130101) A61K 47/36 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) A61P 17/02 (20180101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 2305/08 (20130101) C08J 2333/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149319 | Morris et al. |
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| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Morris (Duarte, California); Tristan Scott (Duarte, California) |
| ABSTRACT | Provided herein are, inter alia, recombinant fusion proteins and exosomes comprising recombinant fusion proteins; wherein the recombinant fusion proteins comprises exosome membrane-associated proteins and exogenous target proteins; pharmaceutical compositions; and methods of using the recombinant fusion proteins, exosomes, and pharmaceutical compositions to treat diseases such as cancer, HIV, and COVID-19. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/912450 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5184 (20130101) Original (OR) Class Peptides C07K 16/1063 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149321 | Du et al. |
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| FUNDED BY |
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| APPLICANT(S) | DuPage Medical Technology, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoping Du (Chicago, Illinois); Ying Liu (Clarendon Hills, Illinois) |
| ABSTRACT | Provided herein is a method of producing peptide nanoparticles comprising vortex-mixing (a) a hydrophobic or amphiphilic peptide or peptide conjugate, (b) one or more lipids that are free of a water-soluble polymer, (c) one or more lipids covalently attached to a water-soluble polymer, and (d) a hydrophilic solvent, to provide peptide nanoparticles. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/802917 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 9/5123 (20130101) A61K 9/5146 (20130101) A61K 9/5192 (20130101) Original (OR) Class A61K 38/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149327 | Marchant et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Stephen Marchant (Brookfield, Wisconsin); Tom Paul Aufderheide (Wauwatosa, Wisconsin) |
| ABSTRACT | Described herein are methods for treating COVID-19 or preventing COVID-19 in a subject exposed to SARS-CoV-2 by administering to the subject a therapeutically effective amount of salmeterol or the pharmaceutically acceptable salt thereof. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/920611 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149338 | SIMPSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Sierra SIMPSON (San Diego, California); Olivier GEORGE (Lemon Grove, California) |
| ABSTRACT | The present disclosure provides a novel treatment for addiction disorders, particularly opioid addiction. More specifically, the present disclosure provides a treatment for opioid addiction comprising a combination use of any one or more of SCFAs in combination with one or more carnitines, providing effective depletion of microbiome in certain brain regions. A diagnosis method for the progress of the addiction treatment is also provided. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/916610 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/205 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149358 | GIUS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Galera Labs, LLC (Malvem, Pennsylvania); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David R. GIUS (Chicago, Illinois); Robert A. BEARDSLEY (University City, Missouri); Yueming ZHU (Chicago, Illinois); Jon HOLMLUND (Carlsbad, California); Jeffery L. KEENE (St. Louis, Missouri) |
| ABSTRACT | A method of treating a cancer in a mammalian subject with a tumor signature characterized by any one or more of (i) a level of sirtuin (SIRT3) protein that is below a first predetermined threshold level, (ii) a level of manganese superoxide dismutase acetylated at the lysine 68 residue (AcK68) that exceeds a second predetermined threshold level, and (iii) expression levels of hypoxia-inducible factor 2α (HIF2α) that exceed a third predetermined threshold level indicative of lineage plasticity for stemness, the method comprising administering to the mammalian subject a therapeutically effective amount of a pentaaza macrocyclic ring complex corresponding to the Formula (I) below, optionally with administration of a further anti-cancer therapeutic agent. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/071724 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4166 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0089 (20130101) Enzymes C12Y 115/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149403 | Siracusa |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, the State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, the State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Mark C. Siracusa (New Brunswick, New Jersey) |
| ABSTRACT | The invention provides methods and compositions that are useful for treating allergic diseases, bacterial infections, fungal infections, viral infections, mastocytosis, mast cell-mediated inflammation and parasite infections (e.g., helminth infections). |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855501 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/423 (20130101) A61K 31/433 (20130101) A61K 31/451 (20130101) A61K 31/505 (20130101) A61K 31/513 (20130101) Original (OR) Class A61K 31/542 (20130101) A61K 31/4184 (20130101) A61K 31/7048 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230149442 — Biodegradable, Antioxidant, Thermally Responsive Injectable Hydrogel and Uses Therefor
| US 20230149442 | Wagner et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. Wagner (Gibsonia, Pennsylvania); Yasumoto Matsumura (Pittsburgh, Pennsylvania); Murugesan Velayutham (Pittsburgh, Pennsylvania); Yang Zhu (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are antioxidant, thermally-responsive polymeric compositions and methods of making and using the compositions, e.g., for treatment of ischemia reperfusion injury or radiation exposure. |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/098473 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0024 (20130101) A61K 31/79 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/145 (20130101) A61L 2400/06 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/54 (20130101) C08F 290/061 (20130101) C08F 299/045 (20130101) C08F 2438/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149460 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Jianzhu Chen (Lexington, Massachusetts); Jerome Ritz (Lincoln, Massachusetts); Rizwan Romee (Wellesley, Massachusetts); Han Dong (Boston, Massachusetts); Guozhu Xie (Cambridge, Massachusetts); James Dongjoo Ham (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to cytokine-induced memory-like NK cells expressing a chimeric antigen receptor polypeptide that binds to a neoepitope of mutant nucleophosmin (NPM1c) in complex with, or presented by, a class I major histocompatibility complex (MHC class I) protein, or cells expressing such compounds, and their use in methods for treating, or ameliorating one or more symptoms of, cancer. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/910776 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/3061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149467 | MONTGOMERY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cellphire, Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | Cellphire, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Joshua Donald MONTGOMERY (Silver Spring, Maryland); Braden Carl ISHLER (Montgomery Village, Maryland); Stephen Edward AMOS (Buckeystown, Maryland); Keith Andrew MOSKOWITZ (Westfield, Indiana); Amber Nicole LEE (Montgomery Village, Maryland); Rafael JORDA (Merignac, France); Glen Michael FITZPATRICK (North Potomac, Maryland); Michael Alexander MATHEWS (Arlington, Virginia) |
| ABSTRACT | Provided herein are materials and methods for the preparation of blood products. In some aspects, provided herein are compositions that include populations of platelet derivatives, including freeze-dried platelet derivatives, methods of producing the same, as well as methods of using the same to treat a subject. Such platelet derivatives have improved properties, as disclosed herein. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 18/052709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 35/19 (20130101) Original (OR) Class A61K 47/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149469 | Frank et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Markus H. Frank (Cambridge, Massachusetts); Natasha Y. Frank (Cambridge, Massachusetts); Dennis P. Orgill (Belmont, Massachusetts); George F. Murphy (Boston, Massachusetts) |
| ABSTRACT | The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947360 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 38/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/3834 (20130101) A61L 27/3886 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/063 (20130101) C12N 5/0668 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149501 | Szeto |
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| FUNDED BY |
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| APPLICANT(S) | Cornell Research Foundation, Inc. (New York, New York) |
| ASSIGNEE(S) | Cornell Research Foundation, Inc. (New York, New York) |
| INVENTOR(S) | Hazel H. Szeto (New York, New York) |
| ABSTRACT | The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic peptide. The aromatic cationic peptide has (a) at least one net positive charge; (b) a minimum of three amino acids; (c) a maximum of about twenty amino acids, (d) a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; (e) a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 3a or 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1; and (f) at least one tyrosine or tryptophan amino acid. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493551 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) Original (OR) Class A61K 38/08 (20130101) A61K 38/10 (20130101) Peptides C07K 5/1019 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149503 | Deb |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arjun Deb (Los Angeles, California) |
| ABSTRACT | The present disclosure relates to compositions and methods for treating a dysregulated wound healing, for improving wound healing, for inhibiting scar formation, for treating a subject with Ehlers Danlos syndrome (EDS), and for treating a subject diagnosed with a heart attack. The present disclosure further relates to compositions and methods for predicting future cardiac risk in a subject who has suffered a heart attack, and predicting risk of future cardiac disease in a subject suffering a heart attack. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/916337 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 19/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149518 | Sauer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karin Sauer (Binghamton, New York); Amber L. Doiron (Vestal, New York) |
| ABSTRACT | A method of treating a biofilm on a surface, comprising: providing a surface having a biofilm; and administering to the surface a treatment that reduces a concentration of pyruvate of the biofilm, comprising pyruvate produced by at least a portion the biofilm, under conditions effective reducing maintenance of the biofilm on the surface. A composition, comprising purified enzyme, within a particle, effective for reducing pyruvate concentration in an aqueous suspension of the composition. |
| FILED | Monday, January 02, 2023 |
| APPL NO | 18/092429 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/18 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/44 (20130101) Original (OR) Class A61K 45/06 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/38 (20210501) Enzymes C12Y 102/04001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149552 | Koehler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Universität Zürich (Zürich, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Angela Nicole Koehler (Belmont, Massachusetts); Shelby Doyle (Cambridge, Massachusetts); Becky Leifer (Malden, Massachusetts); Matthew Henley (Brighton, Massachusetts); Beat W. Schaefer (Zürich, Switzerland); Marco Wachtel (Zürich, Switzerland) |
| ABSTRACT | The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety. Also provided are pharmaceutical compositions containing such compounds and methods of using such compounds. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946898 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149554 | Disney |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Matthew D. Disney (Jupiter, Florida) |
| ABSTRACT | Embodiments of methods are disclosed for inhibiting, regulating and/or otherwise affecting or managing the pri-miR-17-92 cluster, and certain pre-miRNA's embedded in the cluster as well as the pre-miRNA's themselves as isolated forms, as members of a library, present in oncogenic and/or polycystic cell lines and/or that are present in breast cancer, prostate cancer and/or polycystic kidney disease in animals or humans, or present in any other disease in which the pri-miR-17-92 cluster and the certain pre-miRNAs within in it cause or contribute to disease. The methods utilize compounds that target the structural feature or features of the pri-miR-17-92 cluster and/or the certain pre-miRNA's. The pre-miRNA's are members of the pre-miRNA-X group which includes one or more of pre-miR-17, pre-miR-18a, pre-miR-19a, pre-miR-19b-1, pre-miR-20a, and pre-miR-92a-1 or any combination thereof. The compounds incorporate a dimeric formula of a binding moiety for the certain pre-miRNA-X's. The binding moiety can bind or complex with structural feature(s) of the certain pre-miRNA-X's without specificity for the particular nucleotide sequence of the structural features. The binding moiety nevertheless is selective for the certain structural feature(s) so that it does not bind with other pre-miRNA's not having the certain structural feature(s). |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/915985 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/22 (20130101) A61K 47/64 (20170801) Original (OR) Class A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/08 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149656 | Hall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Gregory W. Hall (Belmont, Massachusetts); Ian J. Gillerman (Somerville, Massachusetts); Sina Mohsenian (Billerica, Massachusetts); Aubrey Ortiz (Boston, Massachusetts); Christopher Miles (Acton, Massachusetts); Wolfgang Scholz (Beverly, Massachusetts); Adam J. Young (Dedham, Massachusetts); Benjamin Apollonio (Lunenburg, Massachusetts); Ziad F. Elghazzawi (Newton, Massachusetts) |
| ABSTRACT | Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/049013 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/12 (20130101) Original (OR) Class A61M 16/024 (20170801) A61M 2202/0275 (20130101) A61M 2205/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149745 | KONOFAGOU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Elisa E. KONOFAGOU (New York, New York); Gesthimani Samiotaki (New York, New York) |
| ABSTRACT | Methods and systems for modulation and mapping of brain tissue in a subject using an ultrasound assembly are provided. An exemplary method for modulation uses an ultrasound assembly including a housing and an ultrasound transducer joined to the housing. The method includes securing the housing to the head of the subject with the ultrasound transducer aligned with a region of the brain tissue to target the region of the brain tissue for modulating, and providing focused ultrasound at an acoustic pressure to the targeted region using the ultrasound transducer to induce cavitation proximate the targeted region. The method further includes detecting a cavitation signal magnitude from the induced cavitation corresponding to the acoustic pressure and modulating the targeted region. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/151052 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/13 (20130101) A61B 8/42 (20130101) A61B 8/481 (20130101) A61B 8/0808 (20130101) A61B 8/4254 (20130101) A61B 8/4427 (20130101) A61B 8/4477 (20130101) A61B 8/5261 (20130101) A61B 8/5269 (20130101) A61B 17/225 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/0065 (20130101) A61N 2007/0095 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/52041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149919 | CAMPBELL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TISSUE TESTING TECHNOLOGIES LLC (North Charleston, South Carolina) |
| ASSIGNEE(S) | TISSUE TESTING TECHNOLOGIES LLC (North Charleston, South Carolina) |
| INVENTOR(S) | Lia H. CAMPBELL (Mount Pleasant, South Carolina); Gregory J. WRIGHT (HOT SPRINGS, North Carolina); Elizabeth GREENE (MONCKS CORNER, South Carolina); Kelvin G.M. BROCKBANK (CHARLESTON, South Carolina) |
| ABSTRACT | Described herein are cassettes and methods for using these cassettes for cryopreserving biomaterials (e.g., a bioengineered construct or natural tissue sample) by vitrification while reducing or preventing the loss of viability associated with conventional preservation methods. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/987257 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) Original (OR) Class B01L 3/523 (20130101) B01L 3/5085 (20130101) B01L 9/543 (20130101) B01L 2200/026 (20130101) B01L 2300/0609 (20130101) B01L 2300/0816 (20130101) B01L 2300/0829 (20130101) B01L 2300/0858 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149929 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Newomics Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daojing WANG (Moraga, California); Po Ying YEH (Pleasanton, California) |
| ABSTRACT | Disclosed herein are devices, methods, and systems for separating one or more biological particles from a fluid sample. The devices may comprise a substrate with a fluidic channel disposed therein. The fluidic channel has disposed therein an array of obstacles with a vertical spacing. The vertical spacing may be configured to separate one or more particles from a fluid stream when the stream flows through the fluidic channel. The devices, methods, and systems may be able to separate various types of biological particles at a high efficiency, sensitivity, and/or specificity. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946892 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0816 (20130101) B01L 2400/086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150922 | Brugarolas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pedro Brugarolas (Ithaca, New York); YuPeng Zhou (East Boston, Massachusetts) |
| ABSTRACT | Described herein are fluorinated derivatives of gabapentin and methods of synthesis and methods of use thereof, e.g., in imaging and therapy. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/919848 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0402 (20130101) A61K 51/0446 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 39/00 (20130101) C07B 59/001 (20130101) C07B 59/002 (20130101) C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 229/32 (20130101) Original (OR) Class C07C 235/14 (20130101) Heterocyclic Compounds C07D 209/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150933 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas); Wichita State University (Wichita, Kansas); University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyeong-Ok Chang (Manhattan, Kansas); Yunjeong Kim (Manhattan, Kansas); William C. Groutas (Wichita, Kansas); Stanley Perlman (Iowa City, Iowa) |
| ABSTRACT | Compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: (I) where X comprises a cyclic moiety, R2 is a branched or unbranched alkyl, cycloalkyl, aryl, arylalkyl, alkenyl, alkynyl, amino acid side chain, bicyclic or tricyclic side chain, combinations, and substituted forms thereof, and Z is selected from the group consisting of C1-C6 hydroxyalkyl, aldehydes, alpha-ketoamides, and bisulfite salts, and in particular —CH2OH, —CHO, —CH(0H)S03−Na+, and -[0(C=0)Rw]S03−Na+. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/907745 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/26 (20130101) Original (OR) Class C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150935 | Kwon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ohyun Kwon (Los Angeles, California); Changmin Xie (Los Angeles, California); Jiannan Zhao (Los Angeles, California); Nathan John Dupper (Los Angeles, California); Aslam Shaikh (Los Angeles, California); Jau-Nian Chen (Los Angeles, California); Adam Langenbacher (Los Angeles, California) |
| ABSTRACT | The present disclosure relates to compounds that are capable of modulating calcium ion homeostasis and treating disorders related thereto. The disclosure further relates to methods of making the aforementioned compounds. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/799521 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) Heterocyclic Compounds C07D 207/48 (20130101) Original (OR) Class C07D 401/04 (20130101) C07D 405/04 (20130101) C07D 409/04 (20130101) C07D 413/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150943 | Goodson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Boyd M. Goodson (Carbondale, Illinois); Eduard Y. Chekmenev (Troy, Michigan); Bryce E. Kidd (Carbondale, Illinois); Jamil A. Mashni (Carbondale, Illinois); Miranda Limbach (Creal Springs, Illinois); Yuqing Hou (Carbondale, Illinois); Fan Shi (Houston, Texas) |
| ABSTRACT | The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/149740 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/12 (20130101) B01J 2531/827 (20130101) Heterocyclic Compounds C07D 213/46 (20130101) C07D 213/63 (20130101) C07D 233/60 (20130101) Original (OR) Class C07D 241/12 (20130101) C07D 401/06 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6506 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) G01R 33/282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150948 | Betts et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | H. LEE MOFFITT CONCERT CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Betts (Tampa, Florida); Said M. Sebti (Tampa, Florida); Harshani Lawrence (Tampa, Florida); Nicholas Lawrence (Tampa, Florida); Claudio Anasetti (Tampa, Florida); Joseph Pidala (Tampa, Florida) |
| ABSTRACT | Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft-versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible Treg. In certain aspects, disclosed are compounds of Formula I-V. |
| FILED | Thursday, January 19, 2023 |
| APPL NO | 18/098990 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 239/48 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150960 | Nevler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avinoam Nevler (Narberth, Pennsylvania); Christopher William Schultz (Riverton, New Jersey); Jonathan Robert Brody (Philadelphia, Pennsylvania) |
| ABSTRACT | Described herein are compounds of Formula I and methods of using said compounds for treating, ameliorating, and/or preventing cancer. The compounds are cyanine dyes, and have increased effects in hypoglycemic environments. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/796570 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) A61K 31/428 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 263/56 (20130101) C07D 277/64 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) G16B 25/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150990 | Tu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhude Tu (St. Louis, Missouri); Vijai Kumar Reddy Tangadanchu (St. Louis, Missouri); Hao Jiang (St. Louis, Missouri); Buck Rogers (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of SphK inhibitors and methods of making and using same. An aspect of the present disclosure provides for an SphK2 inhibiting agent, wherein the SphK2 inhibiting agent is a 1,2,3-triazole having SphK2 inhibiting activity and SphK2 selectivity. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/820137 |
| CURRENT CPC | Heterocyclic Compounds C07D 413/10 (20130101) C07D 413/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151021 | Robertson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); BARUCH S. BLUMBERG INSTITUTE (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erle S. Robertson (Wynnewood, Pennsylvania); Yonggang Pei (Philadelphia, Pennsylvania); Yanming Du (Cheshire, Connecticut) |
| ABSTRACT | The present disclosure relates, in part, to certain compounds comprising brusatol derivatives, or a pharmaceutically acceptable salt, solvate, or polymorph thereof, which are useful for the treatment of hematological malignancies, including but not limited to leukemia and lymphoma. In certain embodiments, the present disclosure relates to pharmaceutical compositions of the compounds of the present disclosure. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/920663 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Heterocyclic Compounds C07D 493/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151029 | Reddy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | QPEX BIOPHARMA, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raja K. Reddy (San Diego, California); David C. Griffith (San Marcos, California); Emily Rigsbee (West Lafayette, Indiana); Serge Henri Boyer (San Diego, California); Scott J. Hecker (Del Mar, California); Matthew Jonathan Jones (Linz, Austria) |
| ABSTRACT | Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs). The boronic acid derivatives disclosed herein can be used in combination with various antibiotics to treat resistant bacteria. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/906340 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151052 | REDDY |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A&M UNIVERSITY SYSTEM (COLLEGE STATION, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DOODIPALA SAMBA REDDY (BRYAN, Texas) |
| ABSTRACT | Described herein is the chemical structure of neurosteroid derivative compounds, methods of synthesizing the derivatives, and their uses in treating disorders, including those of the central nervous system. These compounds are readily synthesized and have improved pharmaceutical properties, including water solubility, compared to known neurosteroids. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/091431 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) Steroids C07J 5/0015 (20130101) C07J 41/0088 (20130101) C07J 43/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230151053 — METHODS FOR ASSEMBLY OF TETRACYCLIC COMPOUNDS BY STEREOSELECTIVE C9-C10 BOND FORMATION
| US 20230151053 | Micalizio |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Glenn C. Micalizio (Norwich, Vermont) |
| ABSTRACT | The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 18/050730 |
| CURRENT CPC | Steroids C07J 1/0055 (20130101) C07J 75/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151058 | KRISHNA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REALTA HOLDINGS, LLC (Norfolk, Virginia) |
| ASSIGNEE(S) | REALTA HOLDINGS, LLC (Norfolk, Virginia) |
| INVENTOR(S) | Neel K. KRISHNA (Norfolk, Virginia); Kenji CUNNION (Norfolk, Virginia) |
| ABSTRACT | The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated, purified peptide of 30 amino acids derived from human astrovirus protein, called CP1. The invention is directed to peptide compounds that are peptide mimetics, peptide analogs and/or synthetic derivatives of CP1 having, for example, internal peptide deletions and substitutions, deletions and substitutions at the N-terminus and C-terminus, and that are able to regulate complement activation. The invention further provides pharmaceutical compositions of therapeutically effective amounts of the peptide compounds and a pharmaceutically acceptable carrier, diluent, or excipient for treating a disease or condition associated with complement-mediated tissue damage. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/821032 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/03 (20130101) A61K 38/10 (20130101) A61K 38/162 (20130101) A61K 45/06 (20130101) Peptides C07K 7/08 (20130101) Original (OR) Class C07K 14/005 (20130101) C07K 14/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151064 | VINETZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph VINETZ (New Haven, Connecticut); Michael MATTHIAS (New Haven, Connecticut) |
| ABSTRACT | The invention provides compositions and methods for using Leptospiral virulence modifying (VM) proteins or fragments or fusions thereof, as vaccines and as therapeutic agents for the treatment of cancer. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/760134 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Peptides C07K 14/20 (20130101) Original (OR) Class C07K 2319/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151071 | Sathyanesan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); UNIVERSITY OF SOUTH DAKOTA (Vermillion, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Newton Sathyanesan (Vermillion, South Dakota); Monica Sathyanesan (Vermillion, South Dakota); Jason Petersen (Washington, District of Columbia) |
| ABSTRACT | Disclosed are polypeptides comprising an engineered recombinant EPO. For example, disclosed are polypeptides comprising the sequence of SEQ ID NO: 1. Disclosed are variant Epo polypeptides comprising three amino acid substitutions at positions 20, 45 and 97 of wild type human Epo. Disclosed are polynucleotides comprising a nucleic acid capable of encoding one or more of the disclosed polypeptides. Disclosed are vectors comprising any of the polynucleotides disclosed herein. Disclosed are compositions comprising the disclosed polypeptides, polynucleotides or vectors. Disclosed are cells comprising one or more of the disclosed polypeptides, one or more of the disclosed polynucleotides, and/or one or more of the disclosed vectors. Disclosed are methods of using a therapeutically effective amount of one or more of the disclosed polypeptides, nucleic acids or vectors to a subject in need thereof. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/917264 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/505 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151073 | Topp et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Elizabeth M. Topp (West Lafayette, Indiana); Karthik B. Chandrababu (West Lafayette, Indiana); Harshil K. Renawala (Thana, India) |
| ABSTRACT | The present invention generally relates to peptides with no or substantially reduced fibrillation and their therapeutic uses, in particular to phosphorylated calcitonin peptides that have no measureable or substantially reduced fibrillation in an aqueous environment. Also described herein are pharmaceutical compositions of such compounds and methods for treating a patient suffering from pain, osteoporosis, Paget's disease, and/or hypercalcemia by administering therapeutically effective amounts of such compound alone, or together with other therapeutics, or in a pharmaceutical composition to a patient in need of relief. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/914207 |
| CURRENT CPC | Peptides C07K 14/585 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151075 | Cao |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xu Cao (Baltimore, Maryland) |
| ABSTRACT | A method for treating low back pain (LBP) and/or osteoarthritic pain in a subject in need of treatment thereof, the method comprising administering to the subject a composition comprising a recombinant parathyroid hormone (PTH) and a pharmaceutically acceptable carrier is disclosed. |
| FILED | Wednesday, December 02, 2020 |
| APPL NO | 17/781185 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Peptides C07K 14/635 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151094 | Turtle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Cameron J. Turtle (Seattle, Washington); Roland B. Walter (Seattle, Washington); George S. Laszlo (Seattle, Washington); Salvatore Fiorenza (Seattle, Washington) |
| ABSTRACT | Chimeric antigen receptors (CARs) with binding domains derived from a novel suite of CD33-binding antibodies are described. The CARs include optimized short and intermediate spacer regions. The current disclosure also provides methods of cell expansion/activation processes utilizing IL-2, IL-7, IL-15, and/or IL-21 that improve cellular proliferation and cell lysis of the CARs as described. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/995085 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001111 (20180801) A61K 2039/5156 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2501/2302 (20130101) C12N 2501/2307 (20130101) C12N 2501/2315 (20130101) C12N 2501/2321 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151316 | Huh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongeun Huh (Villanova, Pennsylvania); Mark Mondrinos (Philadelphia, Pennsylvania) |
| ABSTRACT | The presently disclosed subject matter provides a biomimetic organ model, and methods of its production and use. In one exemplary embodiment, the biomimetic organ model can be a multi-layer model including a at least two microchannels and at least one chamber slab with at least one membrane coated with cells disposed between at least one microchannel and the at least one chamber slab. In another exemplary embodiment, the biomimetic organ disease model can be a five-layer model including a first and second microchannel with a membrane-gel layer-membrane coated or encompassing cells disposed between the microchannels. In certain embodiments, at least one device can be coupled to the biomimetic organ model that delivers an agent to at least one microchannel. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/814948 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/22 (20130101) A61L 27/50 (20130101) A61L 27/52 (20130101) A61L 27/3633 (20130101) A61L 27/3804 (20130101) Compositions of Macromolecular Compounds C08L 83/04 (20130101) Apparatus for Enzymology or Microbiology; C12M 3/00 (20130101) C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 23/20 (20130101) C12M 25/02 (20130101) C12M 25/14 (20130101) C12M 29/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0062 (20130101) C12N 5/0068 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) C12N 2535/00 (20130101) C12N 2537/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) G01N 33/5044 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/30 (20130101) G09B 23/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151327 | Gamm et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Gamm (Waunakee, Wisconsin); Steven Mayerl (Colorado Spring, Colorado) |
| ABSTRACT | This disclosure relates to genetically engineered retinal organoids that can be used to test therapeutic treatments. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/820488 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) Original (OR) Class C12N 2503/02 (20130101) C12N 2503/04 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151342 | CHOUDHARY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC (CAMBRIDGE, Massachusetts); THE BRIGHAM AND WOMEN’S HOSPITAL, INC. (BOSTON, Massachusetts); THE GENERAL HOSPITAL CORPORATION (BOSTON, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Donghyun LIM (Cambridge, Massachusetts); Sreekanth VEDAGOPURAM (Boston, Massachusetts); Benjamin EBERT (Boston, Massachusetts); Max JAN (Boston, Massachusetts) |
| ABSTRACT | The disclosure includes compositions comprising synthetic zinc finger degrons, and their use with non-naturally occurring or engineered programmable nucleases. Compositions specifically targeting the engineered programmable nucleases for control of gene editing outcomes, and compositions, systems and method of use are further detailed. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802932 |
| CURRENT CPC | Peptides C07K 14/00 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151363 | JU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| INVENTOR(S) | Jingfang JU (East Setauket, New York); Andrew FESLER (Sound Beach, New York) |
| ABSTRACT | The present disclosure provides modified short-interfering ribosomal nucleic acid compositions that have one or more uracil bases replaced a 5-fluorouracil molecule. More specifically, the present disclosure reveals that the replacement of uracil nucleotides within an siRNA nucleotide sequence with a 5-fluorouracil increases the ability of the short interfering RNA to inhibit cancer progression and tumorigenesis when compared to known cancer therapeutics. As such, the present disclosure provides various short-interfering nucleic acid compositions having 5-fluorouracil molecules incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions comprising the modified nucleic acid compositions, and methods for treating cancers using the same. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/912688 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/335 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151364 | Dudley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel C. Dudley (Minneapolis, Minnesota); Gyeoung-Jin Kang (Minneapolis, Minnesota) |
| ABSTRACT | A method of increasing sodium current in a cardiac cell generally includes introducing into the cardiac cell an miR-488 inhibitor in an amount effective to decrease miR-488 suppression of SCN5A mRNA transcription, thereby increasing sodium current in the cardiac cell. A method of increasing translation of SCN5A mRNA in a cell generally includes introducing into the cell an miR-488 inhibitor in an amount effective to decrease miR-488 suppression of SCN5A mRNA transcription. A method of decreasing arrhythmia in a cardiac cell generally includes introducing into the cardiac cell an miR-488 inhibitor in an amount effective to decrease miR-488 suppression of SCN5A mRNA transcription. A method of treating arrhythmia in a patient having, or at risk of having, arrhythmia generally includes administering to the patient an miR-488 inhibitor in an amount effective to decrease the likelihood or extent of arrhythmia in the patient. In some embodiments of all methods, the miR-488 inhibitor can be an miR-488 antagomir or an miR-488 sponge. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/919307 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151367 | CHATURVEDI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes, A Testamentary Trust Established Under the Will of J. David Glads (San Franciso, California); VxBiosciences, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sonali CHATURVEDI (San Francisco, California); Robert RODICK (Berkeley, California); Leor S. WEINBERGER (San Francisco, California) |
| ABSTRACT | Described herein are compositions defective SARS-CoV-2 constructs and particles that can interfere with or block infection of uninfected cells and methods for generating such defective SARS-CoV-2 constructs and particles. The compositions and methods described herein are useful for treatment of SARS-CoV-2 infections. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/920682 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/1058 (20130101) C12N 15/1065 (20130101) C12N 15/1131 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2770/20021 (20130101) C12N 2770/20022 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151389 | Asokan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Aravind Asokan (Durham, North Carolina); Trevor Gonzalez (Durham, North Carolina); Lawrence Patrick Havlik (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides adeno-associated virus (AAV) vectors, comprising coevolved capsid variant proteins, pharmaceutical compositions, methods of making, and methods for delivering such to a subject. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/922962 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151423 | Kaminsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); UNIVERSITY OF MARYLAND (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary Kaminsky (Ottawa, Canada); Jennifer L. Payne (Baltimore, Maryland); Todd Gould (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of post-partum depression. More specifically, the present invention relates to the use of biomarkers to diagnose post-partum depression or predict a risk thereof. In a specific embodiment, a method for identifying a likelihood of PPD in a patient comprises the steps of (a) providing a sample from the patient; (b) measuring white blood cell type counts and DNA methylation levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises HP1BP3 and TTC9B and the white blood cell type counts comprise monocytes and non-monocytes; and (c) identifying the patient as likely to develop PPD based on the relative DNA methylation levels at the biomarker loci relative to the ratio of monocytes:non-monocytes. |
| FILED | Tuesday, August 11, 2020 |
| APPL NO | 16/990572 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/118 (20130101) C12Q 2600/154 (20130101) C12Q 2600/158 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151430 | Peled et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Jonathan U. Peled (Roosevelt Island, New York); Marcel R.M. Van Den Brink (New York, New York); Antonio Gomes (New York, New York) |
| ABSTRACT | The present disclosure relates to compositions and methods for predicting cancer survival in a subject after receiving a treatment (e.g., allogeneic hematopoietic-cell transplantation). The present disclosure further discloses compositions and methods for treating said subject. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890694 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151434 | Gabrilovich |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dmitry I. Gabrilovich (Villanova, Pennsylvania) |
| ABSTRACT | Provided herein are methods of method of inhibiting the recurrence of cancer in subject associated with stress-induced β-adrenergic pathway signaling. In certain embodiments, the methods include treating a subject with an inhibitor of S100A8/A9. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/995539 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152256 | YU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (BALTIMORE, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yihua (Bruce) YU (Ellicott City, Maryland); Marc B. TARABAN (North Potomac, Maryland) |
| ABSTRACT | A method of using the transverse relaxation rate (R2) of solvent NMR signal to detect filling errors of an alum-containing product in real-time in-line during manufacturing, for example during a fill-finish unit operation. This technique can be used for quality control in vaccine manufacturing to ensure the delivery of the correct concentration of alum-containing product to the product container such as a vial or pre-filled syringe. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/149233 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/084 (20130101) Original (OR) Class G01N 24/085 (20130101) G01N 33/15 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152313 | Farris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oklahoma Medical Research Foundation (Oklahoma City, Oklahoma); The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | A. Darise Farris (Edmond, Oklahoma); Sherri Longobardi (Oklahoma City, Oklahoma) |
| ABSTRACT | The present invention includes a method and kit of determining that a patient negative for anti- Ro autoantibodies has Sjögren’s syndrome (SS) without performing a lip biopsy comprising: obtaining a liquid biological sample from the patient suspected of having SS; determining that the patient is negative for anti-Ro autoantibodies; and detecting autoantibodies to 1, 2, 3, 4, 5, 6, 7, 8, or 9 proteins selected from: CCDC155, DDB1, MUM1L1, NFU1, RPS29, SOX5, TCP10, ZNF655, or RPAP3, which indicate(s) that the patient has SS. Also, a lack of certain autoantibodies such as KCNAB1, KCNAB2, or as listed in Table 1, Table 2, or Table 3, and |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/797619 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152322 | Mahajan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinit Mahajan (Palo Alto, California); Gabriel Velez (Palo Alto, California); Prithvi Mruthyunjaya (Redwood City, California) |
| ABSTRACT | Compositions, methods, and kits are provided for diagnosing and treating uveal melanoma. In particular, biomarkers have been identified that can be used to diagnose uveal melanoma and subtype eye tumors according to their gene expression profile (GEP) class or PRAME status. These biomarkers can be used alone or in combination with one or more additional biomarkers or relevant clinical parameters in prognosis, diagnosis, or monitoring treatment of uveal melanoma. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/796179 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) Original (OR) Class G01N 33/57488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152324 | Hanks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent A. Hanks (Durham, North Carolina); Balamayooran Theivanthiran (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes methods and markers in the NLRP3-HSP70 axis useful for making treatment decisions regarding cancer. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 18/055406 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57488 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152325 | Cukierman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Institute For Cancer Research d/b/a The Research Institute Of Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edna Cukierman (Philadelphia, Pennsylvania); Janusz Franco-Barraza (Philadelphia, Pennsylvania); Neelima Shah (Philadelphia, Pennsylvania) |
| ABSTRACT | Methods for intervening in conditions of active desmoplasia comprise detecting increased levels of active alpha5-beta-1 integrin and the localization of this active integrin intracellularly away from three dimensional matrix adhesions within the stroma of affected tissues, as well as detecting the concomitant enhanced activity of focal adhesion kinase. Once active desmoplasia is detected, treatments may ensue, which induce a desmoplastic extracellular matrix to revert to a normal/innate phenotype, or which alter the standard of care to improve an outcome that would be less beneficial without the detection of a treatment-impeding desmoplasia condition. Liquid biopsies for detecting active desmoplasia are provided. |
| FILED | Monday, June 26, 2017 |
| APPL NO | 16/310566 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) Original (OR) Class G01N 2333/7055 (20130101) G01N 2333/91205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152329 | Ghosh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Indraneel Ghosh (Tucson, Arizona); Matthew Bienick (Tucson, Arizona); Sean Campbell (Bronx, New York); Carl Buchholz (Roanoke, Virginia) |
| ABSTRACT | A method to produce novel split-protein sensors are described herein. The method implements a sequence dissimilarity (SD) based design that can identify potential split-sites in proteins to generate a split-protein pair, and then employs structure guided mutagenesis of the fragmented protein interface to generate split-protein sensors. The sensors have a signal to background ratio >200 and can be readily used to monitor protein-protein interactions and their inhibition in cells. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/905675 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/66 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152331 | Ardehali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Reza Ardehali (LOS ANGELES, California); Shuin Park (LOS ANGELES, California) |
| ABSTRACT | Methods for the detection, monitoring, and treatment of cardiac fibrosis, progression of cardiac fibrosis, or heart failure in a subject comprising: (a) contacting a sample obtained from the subject with a binding agent that binds a region of cartilage intermediate layer protein 1 (CILP) that spans the cleavage site of the CILP precursor or a nucleotide encoding same. The cardiac fibrosis may be associated with one or more of: ischemia, congenital defect, familial fibrosis, infiltrative fibrosis, idiopathic fibrosis, amyloidosis, hemosiderosis, valvular disease, and other idiopathic cardiomyopathies. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/995266 |
| CURRENT CPC | Peptides C07K 14/78 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6887 (20130101) Original (OR) Class G01N 2800/325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152398 | THEIS et al. |
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| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas THEIS (Raleigh, North Carolina); Milad ABOLHASANI (Raleigh, North Carolina); Patrick TOMHON (Raleigh, North Carolina); Sören LEHMKUHL (Raleigh, North Carolina); Suyong HAN (Raleigh, North Carolina) |
| ABSTRACT | In one aspect, the disclosure relates to a compact membrane reactor for parahydrogen induced hyperpolarization, the reactor including an inner tube constructed of a semipermeable membrane, an outer tube surrounding the inner tube, and a means for controlling the magnetic field surrounding the outer tube. In some aspects, multiple compact membrane reactors can be arranged in parallel. In other aspects, the compact membrane reactor is equipped with a mechanism for magnetic field control. Also disclosed are fluid handling systems and sample preparation systems comprising the compact membrane reactors disclosed herein. The compact membrane reactor can be operated in a batch mode, a stopped-flow mode, or a continuous flow mode and can be configured to work with existing NMR spectrometers and MRI instruments. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/916703 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) G01R 33/282 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152403 | Zu |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ZhongLiang Zu (Nashville, Tennessee) |
| ABSTRACT | Imaging methods for assessing the macromolecular content, such as myelin, are of great interest for understanding brain tissue microstructure, and have shown potentials in diagnosing and prognosing demyelinating diseases. for example. Magnetization transfer (MT) is a MRI contrast mechanism that enables detection of macromolecules. Previously, the MT effect has been analyzed by a semi-quantitative method termed magnetization transfer ratio (MTR) or by a quantitative magnetization transfer (qMT) method. However, because MTR does not have enough sensitivity and specificity to myelin, and qMT takes a very long scan time, their translation into clinical scenarios has been limited. This disclosure describes a MT data analysis metric using double saturation pulse offsets and powers (dopMTR). Simulations and experiments using the systems and methods described in this disclosure show that the dopMTR yields much better sensitivity and specificity to MT effect than the conventional MTR, and requires much less scan time than the qMT. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/982190 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5605 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152407 | Jeong et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eun-Kee Jeong (Salt Lake City, Utah); Kyle Jeong (Salt Lake City, Utah); John W. Rose (Salt Lake City, Utah) |
| ABSTRACT | A method for applying a diffusion-weighting gradient during acquisition of diffusion-weighted imaging signals from a selected portion of a nervous system of a subject. Planar diffusion-weighted spin-echo (DWSE) imaging signals and planar diffusion-weighted stimulated-echo (DWSTE) imaging signals can be obtained to provide a plurality of sets of imaging signals. At least one set of imaging signals includes DWSTE signals that are associated with a high-b-value. A signal difference between DWSE imaging signals and DWSTE imaging signals can be corrected based on respective sets of DWSE imaging signals and DWSTE imaging signals having b-values at or near zero. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 17/989096 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) G01R 33/5616 (20130101) G01R 33/56341 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154009 | Feng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xue Feng (Lexington, Kentucky); Quan Chen (Lexington, Kentucky); Kanchan Ghimire (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xue Feng (Lexington, Kentucky); Quan Chen (Lexington, Kentucky); Kanchan Ghimire (Arlington, Virginia) |
| ABSTRACT | The present disclosure relates to a method and apparatus for automatic head and neck organ segmentation. The method includes: receiving 3D images obtained by a CT system or an MRI system; processing the 3D images to transform to patient coordinate system and have the same spatial resolution and matrix size; building a deep learning framework using CNN models for organ segmentation; doubling the size of training dataset by emulating uncollected training data with mirrored images and their corresponding labels; improving the performance by predicting on original and mirrored images and averaging the output probabilities; and post-processing the output from the deep learning framework to obtain final organ segmentation. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/529188 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/168 (20170101) Original (OR) Class G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20216 (20130101) G06T 2207/30004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154215 | Bharti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Kapil Bharti (Potomac, Maryland); Nathan A. Hotaling (Bethesda, Maryland); Nicholas J. Schaub (Gaithersburg, Maryland); Carl G. Simon (Gaithersburg, Maryland) |
| ABSTRACT | A method is provided for non-invasively predicting characteristics of one or more cells and cell derivatives. The method includes training a machine learning model using at least one of a plurality of training cell images representing a plurality of cells and data identifying characteristics for the plurality of cells. The method further includes receiving at least one test cell image representing at least one test cell being evaluated, the at least one test cell image being acquired noninvasively and based on absorbance as an absolute measure of light, and providing the at least one test cell image to the trained machine learning model. Using machine learning based on the trained machine learning model, characteristics of the at least one test cell are predicted. The method further includes generating, by the trained machine learning model, release criteria for clinical preparations of cells based on the predicted characteristics of the at least one test cell. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/983963 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/2148 (20230101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10056 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 20/69 (20220101) Original (OR) Class G06V 20/695 (20220101) G06V 20/698 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154561 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianlin Cheng (Columbia, Missouri); Elham Soltanikazemi (Columbia, Missouri); Raj Shekhor Roy (Columbia, Missouri); Farhan Quadir (Columbia, Missouri) |
| ABSTRACT | Deep learning systems and methods for predicting structural aspects of protein-related complexes are described herein. An example method for predicting inter-chain distances of protein-related complexes includes receiving data associated with a protein-related complex, where the data associated with the protein-related complex includes at least one of a tertiary structural feature and a multiple sequence alignment (MSA)-derived feature. The method also includes inputting the data associated with the protein-related complex into a deep learning model. The method further includes predicting, using the deep learning model, an inter-chain distance map for the protein-related complex. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 17/988461 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/045 (20230101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) G16B 15/30 (20190201) Original (OR) Class G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154586 | Castle et al. |
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| FUNDED BY |
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| APPLICANT(S) | James Castle (Lexington, Kentucky); Quan Chen (Lexington, Kentucky); Xue Feng (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Castle (Lexington, Kentucky); Quan Chen (Lexington, Kentucky); Xue Feng (Lexington, Kentucky) |
| ABSTRACT | The present disclosure relates to a method and apparatus for fast Monte Carlo (MC) dose calculation using a virtual source model (VSM). The method includes: receiving three-dimensional (3D) images obtained by a computed tomography (CT) system; receiving 3D planned dose images, 3D organ segmentation contour images, and radiotherapy plans generated by a treatment planning system (TPS); processing all 3D images to have the same spatial resolution and matrix size; processing 3D CT images to convert image intensity to density; processing the radiotherapy plans to generate instructions on how to simulate plan delivery; building VSM using inverse cumulative density function (CDF) tables for the simulation of radiotherapy plans, wherein the step of building VSM comprises: receiving output data files containing phase-space information for the radiation output of a specific medical linear accelerator treatment head; calculating the probability of particles' inplane and crossplane positions reverse transported from the phase-space surface back to the treatment head; calculating the Gaussian means and standard deviations of particles' positions at the treatment head and determining the criteria for particle source; calculating the probabilities for each particle source; calculating the probabilities for the medical linear accelerator treatment head to produce different particle species; binning the inplane position probability information of particles into a single histogram for each source and particle species; binning the crossplane position probability information of particles into histograms for each bin of the inplane position histogram for each source and particle species; binning the inplane direction cosine probability information of particles into histograms for each bin of the inplane position histogram for each source and particle species; binning the crossplane direction cosine probability information of particles into histograms for each bin of the crossplane position histogram for each source and particle species; binning the kinetic energy probability information of particles into radially binned histograms for each source and particle species; converting probability densities for inplane and crossplane positions, inplane and crossplane direction cosines, and kinetic energies histograms into cumulative probability densities for each source and particle species; and inverting cumulative probability densities and converting into probability binned inverse CDF tables; simulating and transporting external beams using VSM through virtual treatment machines to the 3D CT densities according to radiotherapy plans to produce 3D images of simulated patient dose; and post-processing 3D planned dose, organ segmentation contour, and simulated patient dose images to obtain a final report comparing planned versus simulated dose. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528590 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10081 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 20/10 (20180101) Original (OR) Class G16H 30/40 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154618 | Enderling et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heiko Enderling (New Tampa, Florida); Stefano Pasetto (Tampa, Florida) |
| ABSTRACT | Systems and methods utilizing a Bayesian framework for tumor forecasting are described herein. An example method may include: inputting a plurality of patient data for a patient into a multi-model framework; predicting, using the multi-model framework, a probability of a given treatment producing a given outcome for the patient; and outputting an assessment for the given treatment. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 18/055956 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230148878 | Buller |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark J. Buller (Douglas, Massachusetts) |
| ABSTRACT | The invention in at least one embodiment includes a system and method for detecting and evaluating an adaptive physiological strain index (aPSI) of an individual with a processor and in a further embodiment taking into account the fitness, age and clothing of the individual based upon physiology. The invention in at least one embodiment includes a system and method to calculate the aPSI using physiological measures. In at least one embodiment, the method obtains an individual's skin temperature and heart rate in order to calculate the individual's aPSI. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100361 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/11 (20130101) A61B 5/441 (20130101) A61B 5/725 (20130101) A61B 5/02055 (20130101) Original (OR) Class A61B 2503/20 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230148951 | Thatcher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey E. Thatcher (Irving, Texas); Wensheng Fan (Plano, Texas); Kevin Plant (Richardson, Texas); Faliu Yi (Allen, Texas) |
| ABSTRACT | The present disclosure relates to systems and methods for assessing or predicting the status of wounds such as burns. Systems can include at least one light detection element and one or more processors configured to receive a signal from the at least one light detection element representing light reflected from a tissue region, generate an image having a plurality of pixels depicting the tissue region, and determine a burn status of a subset of pixels of the image using one or more deep learning algorithms. Systems can further be configured to generate a classified image of the tissue region and/or determine a predictive score associated with healing of the wound. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152654 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/445 (20130101) Original (OR) Class A61B 5/4842 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20084 (20130101) G06T 2207/30088 (20130101) G06T 2207/30101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149256 | Blackburn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); North Carollna State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Troy Blackburn (Chapel Hill, North Carolina); Richard Lawrence Goldberg (Chapel Hill, North Carolina); Jackson Richards (Raleigh, North Carolina); Eric Nathan Markley (Oakland, California); Ola Lars Anders Harrysson (Raieigh, North Carolina); Harshad Srinivasan (Burnaby, Canada); Vishnu Veeramachaneni (Fremont, California) |
| ABSTRACT | A wearable local muscle vibratory stimulator includes a frame including a concave surface for conforming to a treatment surface of a subject. The stimulator further includes an electromagnetic oscillator located in the frame for applying vibratory stimulus to a treatment region of the subject located beneath the treatment surface. The stimulator further includes a waveform generator coupled to the oscillator for generating an electrical signal that causes the electromagnetic oscillator to oscillate. The stimulator further includes an accelerometer coupled to the oscillator for measuring frequency and acceleration of oscillation of the oscillator. The stimulator further includes a controller user interface for receiving user input regarding a desired frequency and acceleration of oscillation of the oscillator. The stimulator further includes a controller coupled to the oscillator and the accelerometer for receiving measurements of frequency and acceleration of oscillation of the oscillator from the accelerometer and controlling the frequency and acceleration of oscillation of the oscillator to minimize a difference between the desired frequency and acceleration of oscillation of the oscillator and the frequency and acceleration of oscillation measured by the accelerometer. The stimulator further includes means for securing the frame to the subject so that the oscillator is wearable. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/914305 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 23/0236 (20130101) Original (OR) Class A61H 2201/165 (20130101) A61H 2201/5043 (20130101) A61H 2201/5076 (20130101) A61H 2201/5084 (20130101) A61H 2201/5097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149388 | FUKHARI et al. |
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| FUNDED BY |
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| APPLICANT(S) | EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amir FUKHARI (Potomac, Maryland); Ryan LOUGHLIN (Babridge, Ireland); Vladimir SAVRANSKY (Rockville, Maryland); Andrew WALKER (Dublin, Ireland) |
| ABSTRACT | The present disclosure relates to pharmaceutical compositions comprising an opioid antagonist, isotonicity agent, a preservative agent, a stabilizing agent and citric acid. The pharmaceutical compositions are stable under various storage conditions. Methods of using the pharmaceutical compositions are also disclosed including methods of treatment |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/919574 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 47/12 (20130101) A61K 47/183 (20130101) A61K 47/186 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149606 | BURBANK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NxStage Medical, Inc. (Lawrence, Massachusetts) |
| ASSIGNEE(S) | NxStage Medical, Inc. (Lawrence, Massachusetts) |
| INVENTOR(S) | Jeffrey H. BURBANK (Manchester, Massachusetts); Dennis M. TREU (Castle Rock, Colorado); Daniel Joseph RUBERY, Jr. (Nashua, New Hampshire); Scott W. NEWELL (Ipswich, Massachusetts); James M. BRUGGER (Newburyport, Massachusetts); William J. SCHNELL (Libertyville, Illinois); William K. WEIGEL (Portland, Maine); Steven A. WHITE (Hudson, Massachusetts); Mark T. WYETH (Andover, Massachusetts); Jerome JAMES (Vestavia, Alabama); David DESOUZA (Essex, Massachusetts); Joseph E. TURK, Jr. (North Andover, Massachusetts); Garrett CASEY (Methuen, Massachusetts) |
| ABSTRACT | The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879455 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/34 (20130101) A61M 1/165 (20140204) A61M 1/341 (20140204) A61M 1/1605 (20140204) Original (OR) Class A61M 1/1613 (20140204) A61M 1/1615 (20140204) A61M 1/1647 (20140204) A61M 1/3403 (20140204) A61M 1/3434 (20140204) A61M 1/3437 (20140204) A61M 1/3441 (20130101) A61M 1/3444 (20140204) A61M 1/3448 (20140204) A61M 1/3607 (20140204) A61M 1/3609 (20140204) A61M 1/3635 (20140204) A61M 2205/15 (20130101) A61M 2205/058 (20130101) A61M 2205/502 (20130101) A61M 2205/702 (20130101) A61M 2205/3331 (20130101) A61M 2205/3334 (20130101) A61M 2205/3341 (20130101) A61M 2205/3351 (20130101) A61M 2205/3355 (20130101) A61M 2205/3365 (20130101) A61M 2205/3368 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149760 | Morgan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah Morgan (Raleigh, North Carolina); Gregory Parsons (Raleigh, North Carolina); Morgan Leyonna Willis (Raleigh, North Carolina) |
| ABSTRACT | Provided are MOF-fabric composites having a crystalline MOF adhered directly to fibers of the fabric and methods of making MOF-fabric composites. A solution is adsorbed onto a fabric. The solution can include a metal salt, a linker, and a solvent. The solution is adsorbed onto the fabric and the fabric suspended over a heated vapor. The vapor releases onto the fabric, causing the metal salt, the linker, and the solvent to diffuse out of the polymer fibers. The linker links metal from the metal salts to form crystals attached to the fabric, and the vapor aids crystallization. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/987113 |
| CURRENT CPC | Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/30 (20130101) Original (OR) Class A62D 2101/02 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) B01J 20/261 (20130101) B01J 20/262 (20130101) B01J 20/321 (20130101) B01J 20/3212 (20130101) B01J 20/3219 (20130101) B01J 20/3265 (20130101) B01J 20/28033 (20130101) Treating Textile Materials Using Liquids, Gases or Vapours D06B 5/22 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 11/20 (20130101) D06M 13/335 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149887 | Rogers |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ODH IP CORP. (New York, New York) |
| ASSIGNEE(S) | ODH IP CORP. (New York, New York) |
| INVENTOR(S) | Luke Rogers (Rockville, Maryland) |
| ABSTRACT | A reactor filter washer dryer (R-FWD) apparatus and methods of using the apparatus for producing washed and dried product of a reaction is disclosed. The R-FWD comprises a vessel defining a process chamber, a filter plate laterally disposed on the vessel base, an agitator assembly, a solids discharge port in the vessel operable to remove the solid fraction of the slurry retained by the filter plate, and a filtrate outlet in the vessel for outflowing the liquid phase of the slurry filtered through the filter plate. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/931220 |
| CURRENT CPC | Separation B01D 29/05 (20130101) B01D 39/2027 (20130101) Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 27/90 (20220101) B01F 35/2215 (20220101) B01F 2101/2204 (20220101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0013 (20130101) B01J 19/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150197 | Collino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachel Collino (Goleta, California); Tyler Ray (Goleta, California); Matthew Begley (Goleta, California) |
| ABSTRACT | A method of three-dimensional (3D) printing includes applying a solution to a channel. The solution includes a plurality of anisotropic particles suspending in the solution. Acoustic waves are applied to the channel. The frequency of the acoustic waves is configured to organize the plurality of anisotropic particles into one or more columns of organized anisotropic particles. The channel is connected to a printhead and a waste outlet. The solution comprising the one or more columns of organized anisotropic particles is deposited on a substrate via the printhead outlet. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/091816 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) B29C 64/209 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2063/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150240 | Shah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LaunchBay LLC (North Billerica, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Apoorva P. Shah (Burlington, Massachusetts); Binod Giri (Tewksbury, Massachusetts); Arjan Giaya (Shrewsbury, Massachusetts) |
| ABSTRACT | A biaxially stretchable laminated fabric composite material includes a four-way stretchable fabric and a barrier film. The barrier film and the fabric are selectively attached at a plurality of individual bond points. When the fabric is in an unstretched state, random folds are formed in the unbonded regions of the barrier film. When the fabric is in a stretched state, the random folds are partially or fully flattened to allow the biaxially stretchable laminated fabric composite material to biaxially stretch. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 18/056441 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/14 (20130101) Original (OR) Class B32B 27/12 (20130101) B32B 27/40 (20130101) B32B 27/306 (20130101) B32B 37/0076 (20130101) B32B 37/203 (20130101) B32B 38/1875 (20130101) B32B 2038/0076 (20130101) B32B 2250/04 (20130101) B32B 2305/18 (20130101) B32B 2329/04 (20130101) B32B 2375/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150630 | Morozov et al. |
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| FUNDED BY |
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| APPLICANT(S) | TELEDYNE INSTRUMENTS, INC. (Thousand Oaks, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrey K. Morozov (North Falmouth, Massachusetts); Clayton P. Jones (Falmouth, Massachusetts) |
| ABSTRACT | A sound source for acoustic communication, navigation, and networking of an underwater glider may include a cylindrical body, a rigid front section disposed anteriorly to the cylindrical body, a plurality of metal rods, a resonant pipe surrounding the rods, and a rod-mounted piezo-ceramic transducer disposed between the body and the front section. Each rod may be attached at a first end to an anterior portion of the body and at a second end to a posterior portion of the front section. The pipe may be disposed between the body and the front section. The transducer may be disposed within the pipe. A posterior end of the pipe may be separated from the anterior portion of the body by a first orifice, and an anterior end of the pipe may be separated from the posterior portion of the front section by a second orifice. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/455483 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0651 (20130101) B06B 2201/74 (20130101) Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/04 (20130101) B63G 8/39 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150668 | Allwein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Atomics Aeronautical Systems, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Joseph Allwein (San Luis Obispo, California); Kevin David Koller (Ramona, California); Ryan Bylard (San Diego, California); Roy Hultenius (Encinitas, California) |
| ABSTRACT | Features for in-flight recovery of an unmanned aerial vehicle (UAV). A towline may be deployed by a host aircraft in-flight to recover an in-flight target UAV. The towline or portion thereof may be oriented nearly vertical. The towline may have a fitting thereon. A capture mechanism on the target UAV may have one or more deployable flaps that engage with the near vertical towline and fitting. The flaps may stow to secure the target aircraft to the towline and fitting. The host aircraft may then retract the towline to pull in the target UAV to the host aircraft using a hoist system having a winch. A latching system located in a pylon of the host aircraft, which may be under a wing, may have a towline connector that engages with and secures the target UAV. The host aircraft may have multiple hoist systems for deployment and/or recovery of multiple target UAV's. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/455383 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/021 (20130101) B64C 2201/206 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 3/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150691 | Allwein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Atomics Aeronautical Systems, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Joseph Allwein (San Luis Obispo, California); James William Groves (La Mesa, California); Kevin David Koller (Ramona, California); Ryan Bylard (San Diego, California); Roy Hultenius (Encinitas, California) |
| ABSTRACT | Features for in-flight recovery of an unmanned aerial vehicle (UAV). A towline may be deployed by a host aircraft in-flight to recover an in-flight target UAV. The towline or portion thereof may be oriented nearly vertical. The towline may have a fitting thereon. A capture mechanism on the target UAV may have one or more deployable flaps that engage with the near vertical towline and fitting. The flaps may stow to secure the target aircraft to the towline and fitting. The host aircraft may then retract the towline to pull in the target UAV to the host aircraft using a hoist system having a winch. A latching system located in a pylon of the host aircraft, which may be under a wing, may have a towline connector that engages with and secures the target UAV. The host aircraft may have multiple hoist systems for deployment and/or recovery of multiple target UAV's. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/455376 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/182 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/029 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150943 | Goodson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Boyd M. Goodson (Carbondale, Illinois); Eduard Y. Chekmenev (Troy, Michigan); Bryce E. Kidd (Carbondale, Illinois); Jamil A. Mashni (Carbondale, Illinois); Miranda Limbach (Creal Springs, Illinois); Yuqing Hou (Carbondale, Illinois); Fan Shi (Houston, Texas) |
| ABSTRACT | The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/149740 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/12 (20130101) B01J 2531/827 (20130101) Heterocyclic Compounds C07D 213/46 (20130101) C07D 213/63 (20130101) C07D 233/60 (20130101) Original (OR) Class C07D 241/12 (20130101) C07D 401/06 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6506 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) G01R 33/282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150986 | Lindsley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig W. Lindsley (Brentwood, Tennessee); P. Jeffrey Conn (Nashville, Tennessee); Aaron M. Bender (Spring Hill, Tennessee); Katrina A. Bollinger (Murfreesboro, Tennessee); Trever R. Carter (Nashville, Tennessee); Jerri M. Rook (Nashville, Tennessee); Jonathan W. Dickerson (Nashville, Tennessee); Julie L. Engers (Brentwood, Tennessee); Kayla J. Temple (Spring Hill, Tennessee); Changho Han (Nashville, Tennessee); Matthew Spock (Nashville, Tennessee); Logan A. Baker (Thompson's Station, Tennessee); Thomas M. Bridges (Nashville, Tennessee) |
| ABSTRACT | Disclosed herein are 2,3,5-trifluorophenyl-pyridazine substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/784365 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) C07B 2200/09 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 405/14 (20130101) Original (OR) Class C07D 409/14 (20130101) C07D 498/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151287 | Trelles et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan Pablo Trelles (Sudbury, Massachusetts); Hsi-Wu Wong (Burlington, Massachusetts); John Hunter Mack (Arlington, Massachusetts) |
| ABSTRACT | A first voltage source produces a first voltage such as an AC voltage. Further, a first electrode of a hydrogen generation system conveys the first voltage. The first voltage conveyed over the first electrode generates low-temperature plasma extending between the first electrode and the mass of material. Presence of the low-temperature plasma releases gas from the mass of material. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/984673 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/088 (20130101) B01J 2219/0809 (20130101) B01J 2219/0869 (20130101) B01J 2219/0879 (20130101) B01J 2219/0896 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/02 (20130101) Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/72 (20130101) Original (OR) Class C10J 2300/0946 (20130101) C10J 2300/1238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151342 | CHOUDHARY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC (CAMBRIDGE, Massachusetts); THE BRIGHAM AND WOMEN’S HOSPITAL, INC. (BOSTON, Massachusetts); THE GENERAL HOSPITAL CORPORATION (BOSTON, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Donghyun LIM (Cambridge, Massachusetts); Sreekanth VEDAGOPURAM (Boston, Massachusetts); Benjamin EBERT (Boston, Massachusetts); Max JAN (Boston, Massachusetts) |
| ABSTRACT | The disclosure includes compositions comprising synthetic zinc finger degrons, and their use with non-naturally occurring or engineered programmable nucleases. Compositions specifically targeting the engineered programmable nucleases for control of gene editing outcomes, and compositions, systems and method of use are further detailed. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802932 |
| CURRENT CPC | Peptides C07K 14/00 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151352 | FUNKNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CureVac Manufacturing GmbH (Tübingen, Germany) |
| ASSIGNEE(S) | CureVac Manufacturing GmbH (Tübingen, Germany) |
| INVENTOR(S) | Andreas FUNKNER (Tübingen, Germany); Stefanie DORNER (Tübingen, Germany); Stefanie SEWING (Tübingen, Germany); Johannes KAMM (Tübingen, Germany); Norbert BROGHAMMER (Tübingen, Germany); Thomas KETTERER (Gomaringen, Germany); Thorsten MUTZKE (Reutlingen, Germany) |
| ABSTRACT | The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF). |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/820242 |
| CURRENT CPC | Separation B01D 61/145 (20130101) B01D 71/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1017 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/02 (20130101) G01N 2030/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151367 | CHATURVEDI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes, A Testamentary Trust Established Under the Will of J. David Glads (San Franciso, California); VxBiosciences, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sonali CHATURVEDI (San Francisco, California); Robert RODICK (Berkeley, California); Leor S. WEINBERGER (San Francisco, California) |
| ABSTRACT | Described herein are compositions defective SARS-CoV-2 constructs and particles that can interfere with or block infection of uninfected cells and methods for generating such defective SARS-CoV-2 constructs and particles. The compositions and methods described herein are useful for treatment of SARS-CoV-2 infections. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/920682 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/1058 (20130101) C12N 15/1065 (20130101) C12N 15/1131 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2770/20021 (20130101) C12N 2770/20022 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151434 | Gabrilovich |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dmitry I. Gabrilovich (Villanova, Pennsylvania) |
| ABSTRACT | Provided herein are methods of method of inhibiting the recurrence of cancer in subject associated with stress-induced β-adrenergic pathway signaling. In certain embodiments, the methods include treating a subject with an inhibitor of S100A8/A9. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/995539 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151437 | Cohen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Adam Ezra Cohen (Cambridge, Massachusetts); Dingchang Lin (Cambridge, Massachusetts); Xiuyuan E. Li (Cambridge, Massachusetts); Doyeon Kim (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides methods for profiling cellular events in a cell over time using protein assemblies. Methods for profiling the effect of a stimulus, such as a candidate therapeutic agent, are also provided by the present disclosure. Proteins, polynucleotides (e.g., vectors), and pairs of polynucleotides for use in the methods described herein, as well as systems and kits comprising such proteins, polynucleotides, and pairs of polynucleotides, are also provided herein. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 18/046076 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151492 | Timler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Science Applications International Corporation (Reston, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Timler (River Ridge, Louisiana); David M. Morris (Bloomington, Indiana) |
| ABSTRACT | Catalyst ink may be directly printed to a substrate using a stamp. Printed catalyst ink may converted to a pattern of one or more metal traces. Materials for a stamp and/or a substrate, and/or components of a catalyst ink, may be selected based on attraction of one or more of components of the catalyst ink to one or more print surfaces of the substrate and/or to one or more write surfaces of the stamp. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/527607 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/44 (20130101) B01J 35/006 (20130101) B01J 35/0013 (20130101) B01J 37/345 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/03 (20130101) C09D 11/14 (20130101) C09D 11/107 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/30 (20130101) C23C 18/38 (20130101) C23C 18/1608 (20130101) C23C 18/2053 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151779 | Nemanick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Joseph Nemanick (Santa Monica, California); Andrea Hsu (El Segundo, California); John Schilling (Lancaster, California); John Desain (Redondo Beach, California); Brian Brady (Seal Beach, California); Andrew Cortopassi (Running Springs, California) |
| ABSTRACT | Solid rocket motors are provided herein. In certain embodiments, a solid rocket motor includes a housing containing thin layers of fuel and thin layers of an inert oxidizer, separated by a thin nonconductive layer. The housing has a nozzle at the end for gas release and channeling. Prior to use, the inert oxidizer is activated by electrochemical oxidation which can generate an active oxidizer and additional fuel. Ignition of the oxidizer and fuel can be triggered whereby the contents of the housing can ignite, generating hot gasses to be channeled out through the nozzle to generate thrust. Replacing current state solid rocket motors with embodiments described herein can improve cost, safety and increase capability. The disclosed embodiments can be safe to transport, store, and handle. Additionally, there can be no moving parts unlike hybrid or liquid rocket motors. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/454691 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152167 | Hubble et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David O. Hubble (King George, Virginia); Peter L. Wick, Jr. (Fredericksburg, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | David O. Hubble (King George, Virginia); Peter L. Wick, Jr. (Fredericksburg, Virginia) |
| ABSTRACT | A spinning flat plate calorimeter device is provided for receiving and measuring laser energy. The device includes a circular disk, a shaft, a structure and a motor. The circular disk has temperature-detection instrumentation for measuring temperature from the laser energy. The shaft is supported by distal and proximal bearings. The structure supports the disk, shaft and its bearings. The motor turns the shaft and the disk. Additionally, the disk further includes a flat plate, a yoke wheel and a plurality of spacers. The plate has an obverse face for receiving the laser energy and a reverse face with a spiral groove for attaching the instrumentation. The yoke wheel attaches to the shaft. The thermal isolator spacers mechanically attach the yoke wheel to the flat plate. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 17/975888 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/18 (20130101) G01K 17/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152309 | Glavin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Glavin (Springboro, Ohio); Christopher Muratore (Kettering, Ohio); Melani K. Muratore (Kettering, Ohio) |
| ABSTRACT | The present invention relates to sensor arrays that are more accurate, more sensitive, and more specific with respect to the material that is detected and capable of detecting one or more materials over a wide range. Such sensor arrays can comprises sensors comprising pattern illumination-based annealed coated substrate and one or more functional molecules and process of using same. The method of designing and process of making the sensors for such sensor array yields components that can have one or more electronic and/or optical functionalities that are integrated on the same substrate or film and to which one or more functional molecules can be attached to yield a sensor. Such processes when coupled with the design methods provided herein, allow for the rapid, efficient device prototyping, design change and evolution in the lab and on the production side. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523705 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/0623 (20130101) C23C 14/5813 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/125 (20130101) G01N 33/5438 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152430 | Pascoguin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Bienvenido Melvin L. Pascoguin (San Diego, California); Brittany Lynn (San Diego, California) |
| ABSTRACT | A method for jamming a target includes aiming a pulsed laser at the target using a tracking system. The pulsed laser emits a pulsed laser beam at the target, thereby generating plasma that causes sound waves equal to or less than 5 ft from the target. The pulsed laser beam is swept with a frequency range to find a target frequency, thereby jamming the target. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526406 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/495 (20130101) Original (OR) Class G01S 17/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152478 | DRUKIER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IMAGE INSIGHT INC. (East Hartford, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gordon A. DRUKIER (New Haven, Connecticut); Eric P. RUBENSTEIN (Ellington, Connecticut); Yonatan B. RUBENSTEIN (Ellington, Connecticut); Joshua C. KESSLER (San Diego, California); Peter R. SOLOMON (West Hartford, Connecticut); Marek A. WOJTOWICZ (East Hartford, Connecticut) |
| ABSTRACT | Systems and methods for calibrating multiple electronic devices are described herein. Such methods may include obtaining, by a processor, data from a plurality of reference electronic devices, analyzing, by a processor, the data and calibrating, by the processor, the electronic device based on the analyzed data obtained from the plurality of reference electronic devices. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/869159 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/02 (20130101) G01T 7/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152486 | Ulmer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTELLISENSE SYSTEMS, INC. (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Ulmer (San Pedro, California); David Miller (San Pedro, California); Anthony Michael (Los Angeles, California); Thomas Vu (Rancho Palos Verdes, California); Jeffrey Norell (Los Angeles, California); David Gustavson (Los Angeles, California); Gregory Peng (Long Beach, California); Drew Yenzer (Culver City, California); Haider Rasool (Redondo Beach, California) |
| ABSTRACT | An assembly and method for using weather sensors with enhanced modular capability is disclosed. The weather sensor assembly generally comprises a cap module, middle module, and a base module, where the cap module, middle module(s) and the base module are stacked adjacently to provide environmental sealing, weather sensing, and electrical connectivity to the weather sensor assembly. One or more ring mechanisms may be included that interlock the cap module, middle module(s), base module to form the weather sensor assembly into an integrated unit. Moreover, the ring mechanisms enable further modules to be added to the weather sensor assembly for additional capabilities. By doing so, each of the modules in the weather sensor assembly may be independent units that can be removed, reordered, swapped, and added for desired sensing modalities and environments. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099716 |
| CURRENT CPC | Meteorology G01W 1/04 (20130101) Original (OR) Class G01W 1/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152550 | Hubble et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David O. Hubble (King George, Virginia); Evan Manley Bates (Fredericksburg, Virginia); Peter L. Wick, JR. (Fredericksburg, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | David O. Hubble (King George, Virginia); Evan Manley Bates (Fredericksburg, Virginia); Peter L. Wick, JR. (Fredericksburg, Virginia) |
| ABSTRACT | An actuator mechanism is provided for disposing a plurality of filters into and out of a camera line-of-sight. The mechanism includes a base, a pair of frames, an axial shaft, a plurality of filter housings and a plurality of pivotable drivers. The base includes an auxiliary platform. The frames flank the base, and the shaft is disposed between the frames. Each filter housing holds a corresponding optical filter and is disposable in a deployment position in the line-of-sight and a withdrawn position out of the line-of-sight. The drivers are disposed on the platform. Each driver corresponds to an associated housing and is rotatable along the shaft to swing at least one housing between deployment and withdrawn positions upon command. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/524886 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 7/006 (20130101) Original (OR) Class Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 11/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152754 | ALLEN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | David W. ALLEN (Fairfax, Virginia) |
| ABSTRACT | A system and method for periodically varying a center frequency for assured time transfer in order to securely transfer a signal from a source to a receiver, without adding additional encryption to signal. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529657 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/04 (20130101) G01S 19/215 (20130101) Original (OR) Class Wireless Communication Networks H04W 12/03 (20210101) H04W 12/108 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153124 | ZHAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intelligent Fusion Technology, Inc. (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qi ZHAO (Germantown, Maryland); Yi LI (Germantown, Maryland); Mingjie FENG (Germantown, Maryland); Li LI (Germantown, Maryland); Genshe CHEN (Germantown, Maryland) |
| ABSTRACT | An edge network computing system includes: a plurality of terminal devices; a plurality of edge servers connected to the terminal device through an access network; and a plurality of cloud servers connected to the plurality of edge servers through a core network. Each edge server is configured to: receive a plurality of computing tasks originated from one of the plurality of terminal devices; use a deep Q-learning neural network (DQN) with experience replay to select one of the plurality of could servers to offload a portion of the plurality of computing tasks; and send the portion of the plurality of computing tasks to the selected cloud server and forward results of the portion of the plurality of computing tasks received from the selected cloud server to the originating terminal device. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/490861 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4806 (20130101) G06F 9/44594 (20130101) Original (OR) Class G06F 2209/509 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153573 | Principe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose C. Principe (Gainesville, Florida); Bo Hu (Gainesville, Florida) |
| ABSTRACT | Various embodiments are directed to configuring or training deep neural network (DNN) machine learning models comprising one or more hidden layers and an output layer. Various embodiments provide technical advantages in training DNN machine learning models, including improved computational efficiency and guaranteed optimality. In one embodiment, an example method includes identifying a nonlinear-model-based representation for each hidden layer, which may be a Bank of Wiener Models, a nonlinear units of the hidden layer, and/or the like. The method further includes individually and sequentially configuring the hidden layers, each configured by determining a correlation measure (e.g., a correlation ratio) between the layer output and a target signal. Parameters of the particular hidden layer are modified by maximizing the correlation measure to yield maximal correlation over the space of functions. The method further includes performing automated tasks using the DNN machine learning model after configuring its parameters on a training set. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 18/052400 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Original (OR) Class G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153595 | Fok et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Femtosense, Inc. (San Bruno, California) |
| ASSIGNEE(S) | Femtosense, Inc. (San Bruno, California) |
| INVENTOR(S) | Sam Brian Fok (San Leandro, California); Alexander Smith Neckar (Redwood City, California) |
| ABSTRACT | Systems, apparatus, and methods for thread-based scheduling within a multicore processor. Neural networking uses a network of connected nodes (aka neurons) to loosely model the neuro-biological functionality found in the human brain. Various embodiments of the present disclosure use thread dependency graphs analysis to decouple scheduling across many distributed cores. Rather than using thread dependency graphs to generate a sequential ordering for a centralized scheduler, the individual thread dependencies define a count value for each thread at compile-time. Threads and their thread dependency count are distributed to each core at run-time. Thereafter, each core can dynamically determine which threads to execute based on fulfilled thread dependencies without requiring a centralized scheduler. |
| FILED | Monday, January 02, 2023 |
| APPL NO | 18/149142 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/48 (20130101) G06F 9/3802 (20130101) G06F 9/3818 (20130101) G06F 9/3836 (20130101) G06F 9/3838 (20130101) G06F 9/3851 (20130101) G06F 9/3885 (20130101) G06F 11/3024 (20130101) G06F 11/3433 (20130101) G06F 15/7807 (20130101) G06F 16/901 (20190101) G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 3/10 (20130101) G06N 3/045 (20230101) G06N 3/048 (20230101) G06N 3/063 (20130101) Original (OR) Class Coding; Decoding; Code Conversion in General H03M 7/702 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153596 | Fok et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Femtosense, Inc. (San Bruno, California) |
| ASSIGNEE(S) | Femtosense, Inc. (San Bruno, California) |
| INVENTOR(S) | Sam Brian Fok (San Leandro, California); Alexander Smith Neckar (Redwood City, California) |
| ABSTRACT | Systems, apparatus, and methods for thread-based scheduling within a multicore processor. Neural networking uses a network of connected nodes (aka neurons) to loosely model the neuro-biological functionality found in the human brain. Various embodiments of the present disclosure use thread dependency graphs analysis to decouple scheduling across many distributed cores. Rather than using thread dependency graphs to generate a sequential ordering for a centralized scheduler, the individual thread dependencies define a count value for each thread at compile-time. Threads and their thread dependency count are distributed to each core at run-time. Thereafter, each core can dynamically determine which threads to execute based on fulfilled thread dependencies without requiring a centralized scheduler. |
| FILED | Monday, January 02, 2023 |
| APPL NO | 18/149145 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/48 (20130101) G06F 9/3802 (20130101) G06F 9/3818 (20130101) G06F 9/3836 (20130101) G06F 9/3838 (20130101) G06F 9/3851 (20130101) G06F 9/3885 (20130101) G06F 11/3024 (20130101) G06F 11/3433 (20130101) G06F 15/7807 (20130101) G06F 16/901 (20190101) G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 3/10 (20130101) G06N 3/045 (20230101) G06N 3/048 (20230101) G06N 3/063 (20130101) Original (OR) Class Coding; Decoding; Code Conversion in General H03M 7/702 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153605 | TANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE MITRE CORPORATION (MCLEAN, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HUANG TANG (MCLEAN, Virginia) |
| ABSTRACT | Disclosed herein are system, method, and computer program product embodiments for generating a disease severity index based on a machine learning system executing a one-dimensional convolutional neural network (CNN) using a large kernel. An embodiment operates by collecting training data sets, extracting a training data feature set from the training data sets, weighting features in the training data feature set to generate a weighted training data feature set, selecting a large kernel comprising the weighted training data feature set, executing a one-dimensional convolution of the weighted training data feature set based on the large kernel to generate an aggregation of weighted occurrences and generating an index based on the aggregation of weighted occurrences. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947637 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153669 | McKay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David C. McKay (Ossining, New York); Jay M. Gambetta (Yorktown Heights, New York) |
| ABSTRACT | A quantum computing device including a first plurality of qubits having a first resonance frequency and a second qubit having a second resonance frequency, the second resonance frequency being different from the first resonance frequency; and a first tunable frequency bus configured to couple the first plurality of qubits to the second qubit. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/151039 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153676 | Freedman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danna E. Freedman (Evanston, Illinois); David D. Awschalom (Chicago, Illinois); Dan W. Laorenza (Evanston, Illinois); Majed S. Fataftah (New Haven, Connecticut); Sam L. Bayliss (Chicago, Illinois); Berk Diler (Chicago, Illinois); Peter J. Mintun (Chicago, Illinois) |
| ABSTRACT | A molecular-spin qubit is formed from a coordination complex having a plurality of strong-field ligands bound to a metal-atom center. The ground state has non-zero spin, and the resulting ground-state magnetic sublevels are separated by microwave or millimeter-wave frequencies, even in the absence of an external field. Two of these sublevels may be used as a quantum resource for quantum information processing, quantum communication, quantum memory, sensing, and other applications. Optical pumping to an excited state may be used to spin-polarize the molecular-spin qubit, and to measure its population by detecting photoluminescence. The energy-level structure of the metal-atom center can be modified due to its interaction with the ligands, therefore allowing the molecular-spin qubit to be “chemically tuned” based on the number and type of ligands. Ensembles of these molecular-spin qubits can be controllably deposited on a surface, or otherwise integrated into devices and structures. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/995825 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/2208 (20130101) C07F 11/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154639 | Levy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Jeremy Levy (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described is a method comprising directing an ultra-low voltage electron beam to a surface of a first insulating layer. The first insulating layer is disposed on a second insulating layer. The method includes modifying, by the application of the ultra-low voltage electron beam, the surface of the first insulating layer to selectively switch an interface between a first state having a first electronic property and a second state having a second electronic property. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/917669 |
| CURRENT CPC | Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 5/04 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 37/28 (20130101) H01J 37/147 (20130101) H01J 37/3174 (20130101) H01J 2237/004 (20130101) Electric solid-state devices not otherwise provided for H10N 52/01 (20230201) H10N 60/01 (20230201) H10N 60/30 (20230201) H10N 70/041 (20230201) H10N 70/257 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154717 | Borchard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dymenso LLC (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philipp Borchard (San Francisco, California); Joseph S. Hoh (Richmond, California) |
| ABSTRACT | A high-power vacuum electron device source of 10 mm-0.1 mm wavelength radiation is composed of an electron gun joined to a RF vacuum electronic circuit. The electron gun includes a cathode, a focus electrode, and a grid. It generates an electron beam that is injected into the circuit for amplifying RF waves. The circuit is composed of metal circuit plates, e.g., copper alloy, that mate with each other and are shaped to provide a beam tunnel and RF circuit envelopes. Precision alignment pins made of nickel super alloy, are used to mutually align the metal circuit plates using elastic averaging implemented by positioning the precision alignment pins in precision alignment holes in the metal circuit plates. Preferably, the electron gun is aligned with the circuit using quasi-kinematic coupling. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/530042 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 29/04 (20130101) H01J 29/54 (20130101) H01J 29/66 (20130101) Original (OR) Class H01J 2223/083 (20130101) H01J 2229/481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154875 | Piedra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Analog Devices, Inc. (Wilmington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Piedra (Somerville, Massachusetts); James G. Fiorenza (Carlisle, Massachusetts); Puneet Srivastava (Wilmington, Massachusetts); Andrew Proudman (Medford, Massachusetts); Kenneth Flanders (Reading, Massachusetts); Denis Michael Murphy (Concord, Massachusetts); Leslie P. Green (Framingham, Massachusetts); Peter R. Stubler (Andover, Massachusetts) |
| ABSTRACT | Gallium nitride-based monolithic microwave integrated circuits (MMICs) can comprise aluminum-based metals. Electrical contacts for gates, sources, and drains of transistors can include aluminum-containing metallic materials. Additionally, connectors, inductors, and interconnect devices can also comprise aluminum-based metals. The gallium-based MMICs can be manufactured in complementary metal oxide semiconductor (CMOS) facilities with equipment that produces silicon-based semiconductor devices. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/148982 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/8252 (20130101) H01L 21/28575 (20130101) H01L 23/66 (20130101) Original (OR) Class H01L 23/481 (20130101) H01L 23/53214 (20130101) H01L 27/0605 (20130101) H01L 27/0629 (20130101) H01L 28/60 (20130101) H01L 29/205 (20130101) H01L 29/452 (20130101) H01L 29/2003 (20130101) H01L 29/7786 (20130101) H01L 29/66462 (20130101) H01L 2223/6616 (20130101) H01L 2223/6683 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155136 | Smith |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Kyle Christopher Smith (Champaign, Illinois) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, a porous device, comprising a porous material, and a hierarchical network of flow channels defined in the porous material, wherein at least one flow channel in the hierarchical network of flow channels has a shape that at least partially approximates a cube-root profile or a quartic-root profile. Additional embodiments are disclosed. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980023 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8626 (20130101) Original (OR) Class H01M 4/8878 (20130101) H01M 8/0258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155168 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bioenno Tech LLC (Santa Ana, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhigang Lin (Santa Ana, California); Chunhu Tan (Santa Ana, California); Tianyu Meng (Santa Ana, California) |
| ABSTRACT | Electrolyte-infiltrated composite electrode includes an electrolyte component consisting of a polymer matrix with ceramic nanoparticles embedded in the matrix to form a networking structure of electrolyte. Suitable ceramic nanoparticles have the basic formula Li7La3Zr2O12 (LLZO) and its derivatives such as AlxLi7-xLa3Zr2-y-zTayNbzO12 where x ranges from 0 to 0.85, y ranges from 0 to 0.50 and z ranges from 0 to 0.75, wherein at least one of x, y and z is not equal to 0. The networking structure of the electrolyte establishes an effective lithium-ion transport pathway in the electrode and strengthens the contact between electrode layer and solid-state electrolyte resulting in higher lithium-ion electrochemical cell's cycling stability and longer battery life. Sold-state electrolytes incorporating the ceramic particles demonstrate improved performance. Large dimensional electrolyte-infiltrated composite electrode sheets can be used in all solid-state lithium electrochemical pouch cells which can be assembled into battery packs. |
| FILED | Monday, January 16, 2023 |
| APPL NO | 18/097384 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2004/021 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155179 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lin Ma (Silver Spring, Maryland); Marshall A. Schroeder (Pasadena, Maryland); Oleg A. Borodin (Laurel, Maryland); Travis P. Pollard (Rockville, Maryland); Michael S. Ding (Potomac, Maryland); Kang Xu (Potomac, Maryland) |
| ABSTRACT | An electrochemical cell includes a negative electrode including a metal, metal alloy, or an electrode active material that reversibly intercalates and de-intercalates cations; a positive electrode including (i) an electrode active material that reversibly intercalates and de-intercalates cations or anions, or (ii) an inert host that reversibly catalyzes an external reactant; a separator between the negative electrode and the positive electrode; and an electrolyte including one or more alcohol-based solvents, with one or more salts. The solvents may include methanol, ethanol, isopropanol, triglycerol, 2,2,2-trifluoroethanol, an organic small molecule or macromolecule that contain at least one hydroxyl (OH) group, or a combination thereof. The electrochemical cell may include a mixture of multiple alcohol-based solvents or a mixture of the one or more alcohol-based solvents with water, mixed at select ratios. The electrochemical cell may include one or more additives having a concentration range between 0.01% to 20% by weight. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528719 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/42 (20130101) H01M 4/463 (20130101) H01M 4/466 (20130101) H01M 10/0567 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 50/417 (20210101) H01M 50/437 (20210101) H01M 2300/0042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155836 | Burnett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Architecture Technology Corporation (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin L. Burnett (Prior Lake, Minnesota); Jafar Al-Gharaibeh (Eden Prairie, Minnesota) |
| ABSTRACT | In general, the techniques of this disclosure describe a system for secure serverless authentication. An authenticator node of the system may receive indications of values of authentication factors associated with an entity. The authenticator node may hash the values of the authentication factors to generate double hashed values of the authentication factors. The authenticator node may compare the double hashed values of the authentication factors with trusted authentication information that is encoded in entity credentials associated with the entity. The authenticator node may determine, based at least in part on comparing the double hashed values of the authentication factors with the trusted authentication information, whether the entity is a trusted entity. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/931407 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0643 (20130101) H04L 9/3231 (20130101) H04L 9/3236 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155962 | Ho et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thang Hoang Ho (San Diego, California); Christina Marie de Jesus (La Mesa, California) |
| ABSTRACT | A system with flexible communication interconnections includes devices and a layer-one switch interconnecting disjoint pairings of communication interfaces. The devices each have at least one communication interface. The layer-one switch has ports, each coupled to a respective one of the communication interfaces, which include the communication interface of each of the devices. For every pairing of a first and different second one of the ports within the disjoint pairings, the layer-one switch is configurable to interconnect bidirectional communications between the respective communication interface for the first port and the respective communication interface for the second port. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/530310 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/0866 (20130101) H04L 49/15 (20130101) Original (OR) Class H04L 69/323 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230156473 | MELODIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tommaso MELODIA (Newton, Massachusetts); Francesco RESTUCCIA (Boston, Massachusetts); Salvatore D'ORO (Allston, Massachusetts) |
| ABSTRACT | A method of determining a response of a radio frequency wireless communication system to an adversarial attack is provided. Adversarial signals from an adversarial node are transmitted to confuse a target neural network of the communication system. An accuracy of classification of the incoming signals by the target neural network is determined. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/128437 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/16 (20130101) Wireless Communication Networks H04W 12/122 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230149528 | Rieder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Triad National Security, LLC (LOS ALAMOS, New Mexico); KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (MANHATTAN, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aida E. Rieder (WESTBROOK, Connecticut); KATHERINE M. PFLAUM (MIDDLETOWN, Connecticut); FAYNA C. DIAZ SAN SEGUNDO (BLUE POINT, New York); WILLIAM M. FISCHER (LOS ALAMOS, New Mexico); TATJANA SITT (ESSEX, Connecticut) |
| ABSTRACT | Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype O FMDV strains. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/889737 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/135 (20130101) Original (OR) Class A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149877 | Cummings et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Laura Christine Cummings (Kansas City, Missouri); Eric Benjamin Cole (Lee's Summit, Missouri); Connor Daniel Pearson (Overland Park, Kansas) |
| ABSTRACT | An apparatus, methods, and systems for forming microspheres comprises a furnace and an ultrasonic nozzle. The furnace has a channel and is operable to generate heat in the channel. The ultrasonic nozzle is configured to receive precursor solution and spray precursor droplets into the channel so that the heat in the channel causes the precursor droplets to form the microspheres. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/987654 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/04 (20130101) Original (OR) Class Spraying Apparatus; Atomising Apparatus; Nozzles B05B 17/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149912 | TAIT, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven L. TAIT, JR. (Bloomington, Indiana); Iyad Syed ALI (Chesterton, Indiana); Linxiao CHEN (Issaquah, Washington) |
| ABSTRACT | The invention describes metal catalysts such as Pt single-site centers on metal oxide supports, e.g., powdered supports, such as MgO, Al2O3, CeO2 or mixtures thereof with phenyl or biphenyl ligands substituted with two or more carboxylic acid groups. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/921012 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/10 (20130101) B01J 31/26 (20130101) B01J 31/1815 (20130101) B01J 31/2239 (20130101) Original (OR) Class B01J 2231/323 (20130101) B01J 2531/828 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/1876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150007 | Reyes |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Joseph Reyes (Gladstone, Missouri) |
| ABSTRACT | A tool for handling a die assembly, the tool including a rocker and a swivel. The rocker includes a foot and a backrest. The foot engages a base of the die assembly when the tool is upright and stabilizes the die assembly as the tool is leaned from being upright to reclined. The backrest extends vertically from the foot when the tool is upright. The swivel supports an outer shell and other components of the die assembly on the backrest and translates and rotates relative to the backrest when the tool is reclined to rotate the outer shell and other components from an inverted orientation to a non-inverted orientation. The foot stabilizes the die as the tool is leaned from being reclined to upright and can be moved horizontally out of engagement with the base when the tool is upright. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/527793 |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 37/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150021 | Tappan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Bryce Tappan (Santa Fe, New Mexico); Andrew Schmalzer (Los Alamos, New Mexico); Alexander H. MUELLER (Santa Fe, New Mexico) |
| ABSTRACT | Processes for tailoring the macroscopic shape, metallic composition, mechanical properties, and pore structure of nanoporous metal foams prepared through combustion synthesis via direct write 3D printing of metal energetic ligand precursor inks made with water and an organic thickening agent are disclosed. Such processes enable production of never before obtainable metal structures with hierarchical porosity, tailorable from the millimeter size regime to the nanometer size regime. Structures produced by these processes have numerous applications including, but not limited to, catalysts, heat exchangers, low density structural materials, biomedical implants, hydrogen storage medium, fuel cells, and batteries. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/098035 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1121 (20130101) Original (OR) Class B22F 10/00 (20210101) B22F 10/60 (20210101) B22F 2998/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/52 (20130101) Alloys C22C 1/08 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150022 | Whalen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott A. Whalen (West Richland, Washington); Jens T. Darsell (West Richland, Washington); MD. Reza-E-Rabby (Richland, Washington); Brandon Scott Taysom (West Richland, Washington); Tianhao Wang (Richland, Washington); Darrell R. Herling (Kennewick, Washington); Xiao Li (Richland, Washington) |
| ABSTRACT | A method for preparing a shear-assisted extruded material from a powder billet is provided, the method comprising providing a billet of material in substantially powder form; applying both axial and rotational pressure to the material to deform at least some of the contacted material; and extruding the material to form an extruded material. A method for preparing shear-assisted extruded material is provided, the method comprising applying both axial and rotational pressure to stock material to form an extruded material at a rate between 2 and 13 m/min. A method for preparing shear-assisted extruded material is provided. The method comprises applying both axial and rotational pressure to stock material to form an extruded material; and aging the extruded material for less than 3 hours. A method for preparing shear-assisted extruded material is provided. The method comprises providing a stock material for shear-assisted extrusion; and applying both axial and rotational force to the stock material to form an extruded material, wherein the axial force does not decrease during the extrusion. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/093636 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/20 (20130101) Original (OR) Class B22F 3/24 (20130101) B22F 2003/248 (20130101) B22F 2301/052 (20130101) B22F 2302/25 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150502 | Dickson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | Cummins Inc. (Columbus, Indiana) |
| INVENTOR(S) | Jonathan A. Dickson (Columbus, Indiana); Kenneth M. Follen (Greenwood, Indiana); Arun Prakash Thunga Gopal (Columbus, Indiana); J. Steven Kolhouse (Columbus, Indiana); Manik Narula (Columbus, Indiana); Apurva Arvind Chunodkar (Greenwood, Indiana) |
| ABSTRACT | Systems, methods, and apparatuses for improving predictive cruise control and predictive engine off coasting for a vehicle are provided. An apparatus includes one or more processing circuits having one or more memory devices coupled to one or more processors, the one or more memory devices configured to store instructions thereon that, when executed by the one or more processors, cause the one or more processors to: receive look ahead information and store the look ahead information in the one or more memory devices; receive vehicle information regarding operation of a vehicle including an engine; determine a coasting opportunity for the vehicle based on the look ahead information and the vehicle information; modulate a cruise control set speed based on the determined coasting opportunity; and turn the engine off during the determined coasting opportunity for the vehicle based on modulation of the cruise control set speed. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/984735 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/143 (20130101) B60W 30/18072 (20130101) Original (OR) Class B60W 50/14 (20130101) B60W 2030/1809 (20130101) B60W 2510/06 (20130101) B60W 2510/10 (20130101) B60W 2510/30 (20130101) B60W 2552/15 (20200201) B60W 2554/00 (20200201) B60W 2554/802 (20200201) B60W 2555/20 (20200201) B60W 2555/60 (20200201) B60W 2710/1005 (20130101) B60W 2720/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150821 | Gailus |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nanocomp Technologies Inc. (The Woodlands, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Gailus (Merrick, New Hampshire) |
| ABSTRACT | The present disclosure provides a method for producing elongated non-entangled nanotube filaments using a vertical upward flow floating catalyst chemical vapor deposition system. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/916860 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/162 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151031 | Luo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tianyi Luo (Baltimore, Maryland); Michael Tsapatsis (Baltimore, Maryland); Zhiyong Xia (Baltimore, Maryland) |
| ABSTRACT | The present disclosure relates to modified metal-organic frameworks (MOFs) and a post-synthetic modification method that simultaneously enhances hydrophilicity and water stability to achieve high-performance water sorption materials. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 18/054956 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151033 | Even |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dakota Even (Overland Park, Kansas) |
| ABSTRACT | A method for forming monosubstituted diphenylsilanes is broadly provided. The method involves reacting diphenylsilane with an alcohol in the presence of a catalyst and a strong base activator. The reaction results in high selectivity to addition at only one hydrogen site. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528747 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2273 (20130101) B01J 2531/16 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151340 | BECKHAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); University of Portsmouth (Portsmouth, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregg Tyler BECKHAM (Golden, Colorado); Erika Marie ERICKSON (Berkeley, California); John E. MCGEEHAN (Portsmouth, United Kingdom) |
| ABSTRACT | The present disclosure relates to a non-naturally occurring enzyme that includes a first polypeptide that catalyzes the hydrolysis of a polyester to produce mono-(2-hydroxyethyl) terephthalate (MHET), a second polypeptide that catalyzes the cleavage of MHET to produce at least one of terephthalic acid or ethylene glycol, and a third polypeptide that links the first polypeptide with the second polypeptide. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/921833 |
| CURRENT CPC | Disposal of Solid Waste B09B 3/60 (20220101) B09B 2101/75 (20220101) Peptides C07K 2319/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/105 (20130101) C08J 2367/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151450 | Codd et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Daniel S. Codd (San Diego, California); Joseph J. McCrink (Carlsbad, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel S. Codd (San Diego, California); Joseph J. McCrink (Carlsbad, California) |
| ABSTRACT | An integrated welding and thermal processing method includes heating adjoining surfaces, at least one of which is a creep strength enhanced ferritic (CSEF) steel alloy, to a sufficiently high temperature above their melting points to form a weld. The weld is allowed cool below the martensitic start temperature of one or both CSEF alloys. Thereafter, a supplemental heat source tempers the CSEF alloys by reheating the weld area at a rate of 10° C. per second or greater to above the CSEF alloys’ martensitic start temperatures, but not above the austenitization temperature of the CSEF alloys. After the weld’s heat affected zone is maintained at a temperature between the CSEF alloys’ martensitic finish temperature and martensitic start temperature, the weld is allowed to cool at a rate of 15° C. per minute or greater. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/987484 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 31/027 (20130101) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 1/42 (20130101) C21D 6/002 (20130101) C21D 6/005 (20130101) C21D 9/08 (20130101) Original (OR) Class C21D 2211/008 (20130101) Alloys C22C 38/001 (20130101) C22C 38/04 (20130101) C22C 38/22 (20130101) C22C 38/24 (20130101) C22C 38/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151499 | Feaster et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jeremy Taylor Feaster (Fremont, California); Roger D. Aines (Livermore, California); Sneha Anil Akhade (Oakland, California); Sarah E. Baker (Dublin, California); Patrick G. Campbell (Oakland, California); Maira R. Cerón Hernández (Brentwood, California); Jonathan Tesner Davis (Oakland, California); Eric B. Duoss (Dublin, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy Taylor Feaster (Fremont, California); Roger D. Aines (Livermore, California); Sneha Anil Akhade (Oakland, California); Sarah E. Baker (Dublin, California); Patrick G. Campbell (Oakland, California); Maira R. Cerón Hernández (Brentwood, California); Jonathan Tesner Davis (Oakland, California); Eric B. Duoss (Dublin, California) |
| ABSTRACT | An advanced manufactured electrochemical reactor to convert air (N2+O2) to nitric acid (HNO3) and ammonia (NH3). The electrochemical reactor platform can be tailored via advanced manufacturing to improve activity, selectivity, energy efficiency and stability of the reactions. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 18/052310 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/22 (20130101) C25B 1/27 (20210101) Original (OR) Class C25B 11/077 (20210101) C25B 11/081 (20210101) C25B 11/089 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151868 | Bird |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Portland State University (Portland, Oregon) |
| ASSIGNEE(S) | Portland State University (Portland, Oregon) |
| INVENTOR(S) | Jonathan Bird (Portland, Oregon) |
| ABSTRACT | Various examples of a variable stiffness magnetic spring with a linear stroke length are provided. The stiffness of the magnetic springs is varied through rotation of one or more magnets, and both positive and negative spring constants are achievable. In one example, a variable stiffness magnetic spring includes a first magnetic component and a second magnetic component, wherein the first magnetic component is coaxial with the second magnetic component, the first magnetic component is rotatable about an axis and relative to the second magnetic component to adjust a stiffness of the variable stiffness magnetic spring, and the second magnetic component is translatable along the axis and relative to the first magnetic component. While such variable stiffness magnetic springs exhibit highly linear stroke lengths, such variable stiffness magnetic springs can be positioned in series to achieve an even longer linear stroke length. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966734 |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 6/005 (20130101) Original (OR) Class F16F 2222/06 (20130101) F16F 2228/066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152090 | MUKHERJEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Saptarshi MUKHERJEE (Milpitas, California); Tammy CHANG (San Ramon, California) |
| ABSTRACT | The present disclosure relates to a system for detecting and analyzing droplets of feedstock material being ejected from an additive manufacturing device. The system makes use of a split ring resonator (SRR) probe including a ring element having a gap, with the gap being positioned adjacent a path of travel of the droplets of feedstock material. An excitation signal source is used for supplying an excitation signal to the SRR probe. An analyzer analyzes signals generated by the SRR probe in response to perturbations in an electric field generated by the SRR probe as the droplets of feedstock material pass the ring element. The signals are indicative of dimensions of the droplets of feedstock material. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/455549 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/00 (20141201) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 15/00 (20130101) G01B 21/12 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152362 | Tilles |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julia Napolin Tilles (Albuquerque, New Mexico) |
| ABSTRACT | An interferometric radioimager provides real-time, high-fidelity radioimaging of high voltage breakdown (HVB) both internal and external to electrical components at sub-nanosecond and sub-millimeter resolution and has an ability to resolve multiple/spatially-extensive HVB simultaneously. Therefore, radioimaging can be used to screen for early life weakness/failure and enable non-destructive screening of defective electrical components. In particular, radioimaging can detect precursors to catastrophic HVB, allowing for early detection of weakness in critical electrical components. Radioimaging can also be used to track HVB and pinpoint defects in electrical components real time, including transformers, capacitors, cables, switches, and microelectronics. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 17/990405 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/12 (20130101) G01R 31/1218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153676 | Freedman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danna E. Freedman (Evanston, Illinois); David D. Awschalom (Chicago, Illinois); Dan W. Laorenza (Evanston, Illinois); Majed S. Fataftah (New Haven, Connecticut); Sam L. Bayliss (Chicago, Illinois); Berk Diler (Chicago, Illinois); Peter J. Mintun (Chicago, Illinois) |
| ABSTRACT | A molecular-spin qubit is formed from a coordination complex having a plurality of strong-field ligands bound to a metal-atom center. The ground state has non-zero spin, and the resulting ground-state magnetic sublevels are separated by microwave or millimeter-wave frequencies, even in the absence of an external field. Two of these sublevels may be used as a quantum resource for quantum information processing, quantum communication, quantum memory, sensing, and other applications. Optical pumping to an excited state may be used to spin-polarize the molecular-spin qubit, and to measure its population by detecting photoluminescence. The energy-level structure of the metal-atom center can be modified due to its interaction with the ligands, therefore allowing the molecular-spin qubit to be “chemically tuned” based on the number and type of ligands. Ensembles of these molecular-spin qubits can be controllably deposited on a surface, or otherwise integrated into devices and structures. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/995825 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/2208 (20130101) C07F 11/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153699 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRIAD National Security, LLC. (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yue Chen (Los Alamos, New Mexico); Youzuo Lin (Los Alamos, New Mexico); Rafael Pires de Lima (Los Alamos, New Mexico); Saurabh Sinha (Los Alamos, New Mexico) |
| ABSTRACT | A method includes receiving a plurality of data sets, wherein the plurality of data sets includes a measured low-energy electrons that is less than or equal to 1.5 MeV, and wherein the plurality of data sets further includes data associated with solar wind. The method further includes receiving measured data associated with higher electron events of greater than or equal to 2 MeV In response to a selection of at least two data sets from the plurality of data sets, and further in response to a selection of one or more machine learning (ML) algorithms from a plurality of ML algorithms, and further in response to a selection of a number of window size, a plurality of ML models is generated based on the selections as an input and the measured data associated with higher electron events of greater than or equal to 2 MeV as its output. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499591 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 5/00 (20130101) Computer Systems Based on Specific Computational Models G06N 20/20 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154555 | RAASCH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ADVANCED MICRO DEVICES, INC. (SANTA CLARA, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | STEVEN RAASCH (BOXBOROUGH, Massachusetts); GREG SADOWSKI (BOXBOROUGH, Massachusetts); DAVID A. ROBERTS (BOXBOROUGH, Massachusetts) |
| ABSTRACT | Exemplary embodiments provide wear spreading among die regions (i.e., one or more circuits) in an integrated circuit or among dies by using operating condition data in addition to or instead of environmental data such as temperature data, from each of a plurality of die regions. Control logic produces a cumulative amount of time each of the plurality of die regions has spent at an operating condition based on operating condition data wherein the operating condition data is based on at least one of the following operating characteristics: frequency of operation of the plurality of die regions, an operating voltage of the plurality of die regions, an activity level of the plurality of die regions, a timing margin of the plurality of die regions, and a number of detected faults of the plurality of die regions. The method and apparatus spreads wear among the plurality of same type of die regions by controlling task execution among the plurality of die regions using the die wear-out data. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154372 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/064 (20130101) G06F 3/0616 (20130101) G06F 3/0679 (20130101) G06F 9/50 (20130101) G06F 12/0223 (20130101) G06F 12/0246 (20130101) G06F 2212/1036 (20130101) G06F 2212/7211 (20130101) Static Stores G11C 7/04 (20130101) G11C 11/4076 (20130101) G11C 16/349 (20130101) G11C 16/3418 (20130101) G11C 16/3495 (20130101) Original (OR) Class G11C 29/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154561 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianlin Cheng (Columbia, Missouri); Elham Soltanikazemi (Columbia, Missouri); Raj Shekhor Roy (Columbia, Missouri); Farhan Quadir (Columbia, Missouri) |
| ABSTRACT | Deep learning systems and methods for predicting structural aspects of protein-related complexes are described herein. An example method for predicting inter-chain distances of protein-related complexes includes receiving data associated with a protein-related complex, where the data associated with the protein-related complex includes at least one of a tertiary structural feature and a multiple sequence alignment (MSA)-derived feature. The method also includes inputting the data associated with the protein-related complex into a deep learning model. The method further includes predicting, using the deep learning model, an inter-chain distance map for the protein-related complex. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 17/988461 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/045 (20230101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) G16B 15/30 (20190201) Original (OR) Class G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154635 | ARNDT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Jeffrey L. ARNDT (Pittsburgh, Pennsylvania); Paolo FERRONI (Pittsburgh, Pennsylvania); Cory A. STANSBURY (Gorham, Maine) |
| ABSTRACT | A non-invasive eddy current flow meter embedded into a coolant channel for measuring the coolant flow velocity of liquid metal coolant in a nuclear reactor. The eddy current flow meter measures the coolant flow velocity in pool-type nuclear reactors and narrow coolant channels without creating bottlenecks that impede the coolant flow within the nuclear reactors. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/454920 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/588 (20130101) Nuclear Reactors G21C 17/032 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 9/0081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155153 | Huo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Twelve Benefit Corporation (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ziyang Huo (Moraga, California); Chengtian Shen (Irvine, California); Kenneth X. Hau (San Jose, California); Angelica L. Reyes (Berkeley, California) |
| ABSTRACT | Aspects of this disclosure pertain to catalyst compositions that include electrically conductive support particles; and metal catalyst particles attached to the electrically conductive support particles. The catalyst compositions may be used in cathodes of carbon oxide reduction electrolyzers. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 18/053945 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/926 (20130101) H01M 4/8673 (20130101) H01M 4/9041 (20130101) H01M 4/9083 (20130101) H01M 8/1004 (20130101) Original (OR) Class H01M 2250/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155155 | Song et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ESS TECH, INC. (Wilsonville, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Song (West Linn, Oregon); Kenneth Kiyoshi Fisher (Porland, Oregon); Timothy McDonald (Portland, Oregon) |
| ABSTRACT | Methods and systems are provided for transporting and hydrating a redox flow battery system with a portable field hydration system. In one example, the redox flow battery system may be hydrated with the portable field hydration system in a dry state, in the absence of liquids. In this way, a redox flow battery system may be assembled and transported from a battery manufacturing facility to an end-use location off-site while the redox flow battery system is in the dry state, thereby reducing shipping costs, design complexities, as well as logistical and environmental concerns. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/150751 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/86 (20130101) H01M 8/188 (20130101) Original (OR) Class H01M 8/04119 (20130101) H01M 8/04225 (20160201) H01M 8/04283 (20130101) H01M 50/60 (20210101) H01M 2004/8684 (20130101) H01M 2004/8689 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155175 | Zhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wildcat Discovery Technologies, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ye Zhu (San Diego, California); Gang Cheng (San Diego, California); Deidre Strand (San Diego, California); Jen-Hsien Yang (San Diego, California) |
| ABSTRACT | Additives to electrolytes that enable the formation of comparatively more robust SEI films on silicon-based anodes. The SEI films in these embodiments are seen to be more robust in part because the batteries containing these materials have higher coulombic efficiency and longer cycle life than comparable batteries without such additives. The additives preferably contain a dicarbonate group or are an organo-metallic hydride. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/870460 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/134 (20130101) H01M 4/386 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155384 | Chinthavali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Madhu Sudhan Chinthavali (Oak Ridge, Tennessee); Michael Starke (Oak Ridge, Tennessee); Radha Krishna Moorthy (Oak Ridge, Tennessee); Steven Campbell (Oak Ridge, Tennessee) |
| ABSTRACT | A hierarchical approach is provided to integrate functions and components into the various systems and subsystems within a distribution network, including standardization of modular and scalable power electronics power blocks with embedded diagnostics and prognostics. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 17/989373 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 1/14 (20130101) H02J 1/084 (20200101) H02J 3/16 (20130101) Original (OR) Class H02J 3/381 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155389 | Chinthavali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Madhu Sudhan Chinthavali (Oak Ridge, Tennessee); Michael Starke (Oak Ridge, Tennessee); Radha Krishna Moorthy (Oak Ridge, Tennessee); Steven Campbell (Oak Ridge, Tennessee) |
| ABSTRACT | A hierarchical approach is provided to integrate functions and components into the various systems and subsystems within a distribution network, including standardization of modular and scalable power electronics power blocks with embedded diagnostics and prognostics. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 17/989376 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/06 (20130101) H02J 3/16 (20130101) H02J 3/381 (20130101) Original (OR) Class H02J 2203/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155390 | Chinthavali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Madhu Sudhan Chinthavali (Oak Ridge, Tennessee); Michael Starke (Oak Ridge, Tennessee); Radha Krishna Moorthy (Oak Ridge, Tennessee); Steven Campbell (Oak Ridge, Tennessee) |
| ABSTRACT | A hierarchical approach is provided to integrate functions and components into the various systems and subsystems within a distribution network, including standardization of modular and scalable power electronics power blocks with embedded diagnostics and prognostics. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 17/989379 |
| CURRENT CPC | Boards, Substations, or Switching Arrangements for the Supply or Distribution of Electric Power H02B 1/00 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/381 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230156380 | McDonald et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Spring, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas McDonald (Fort Collins, Colorado); Gary Gostin (Plano, Texas); Alan Davis (Palo Alto, California) |
| ABSTRACT | A system for hot swapping a network switch without disconnecting the network switch connectors is provided. The system disaggregates the switch faceplate network cable connectors from the internal components of the network switch so that the internal switch components may be removed from the switch without disconnecting the switch network cables. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154580 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 49/15 (20130101) H04L 49/30 (20130101) H04L 49/45 (20130101) Selecting H04Q 11/0005 (20130101) Original (OR) Class H04Q 2011/0041 (20130101) H04Q 2011/0052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230157039 | ZHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai ZHU (Littleton, Colorado); Jinhui TONG (Golden, Colorado); Qi JIANG (Lakewood, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes a perovskite phase having the stoichiometry ABX3 and a perovskite-like phase having the stoichiometry A′2A″B′2X′, where A is a first cation, B is a second cation, X is a first anion, A′ is a third cation, A″ is a fourth cation, B′ is a fifth cation, X′ is a second anion, and A′ is different than A″. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/814433 |
| CURRENT CPC | Organic electric solid-state devices H10K 30/57 (20230201) Original (OR) Class H10K 85/50 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230149216 | Knox et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne Knox (Rochester, New York); Jonathan D. Ellis (Tucson, Arizona); Krystel R. Huxlin (Rush, New York); Daniel R. Brooks (Rochester, New York); Kaitlin T. Wozniak (Rochester, New York) |
| ABSTRACT | Refractive index writing system and methods employing a pulsed laser source for providing a pulsed laser output at a first wavelength; an objective lens for focusing the pulsed laser output to a focal spot in an optical material; a scanner for relatively moving the focal spot with respect to the optical material at a relative speed and direction along a scan region for writing one or more traces in the optical material defined by a change in refractive index; and a controller for controlling laser exposures along the one or more traces in accordance with a calibration function for the optical material to achieve a desired refractive index profile in the optical material. The refractive index writing system may be for writing traces in in vivo optical tissue, and the controller may be configured with a calibration function obtained by calibrating refractive index change induced in enucleated ocular globes. A real-time process control monitor for detecting emissions from the optical material transmitted through the objective lens at a second wavelength may further be employed while writing the one or more traces. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099402 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00804 (20130101) A61F 9/00827 (20130101) Original (OR) Class A61F 2009/00855 (20130101) A61F 2009/00897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149620 | Turer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); UPMC (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); UPMC (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | David Turer (Pittsburgh, Pennsylvania); William W. Clark (Wexford, Pennsylvania); April Lawrence (Pittsburgh, Pennsylvania); Ehsan Qaium (Pittsburgh, Pennsylvania); Joseph P. Rubin (Pittsburgh, Pennsylvania); Cameron Dezfulian (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed cannula systems can detect the tissue type within which the cannula tip is located in real time using electrodes adjacent the cannula tip. The sensing cannula system can differentiate when the cannula tip is in adipose tissue or muscle based on electrical impedance. The system can be used in fat grafting and liposuction procedures, for example. An operator can detect if the cannula tip enters muscle by watching for an indicator light or audible alarm that is automatically activated by the device based on a change in sensed impedance. The device may also stop the flow of fat through a pump halting injection into the sub-muscular space. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/149394 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/73 (20210501) A61M 1/743 (20210501) Original (OR) Class A61M 2202/08 (20130101) A61M 2205/581 (20130101) A61M 2205/584 (20130101) A61M 2205/587 (20130101) A61M 2205/3584 (20130101) A61M 2230/65 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149832 | Menkhaus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NANOPAREIL, LLC (Dakota Dunes, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd J. Menkhaus (Dakota Dunes, South Dakota); Steven Schneiderman (Dakota Dunes, South Dakota) |
| ABSTRACT | The present disclosure provides surface functionalized affinity membranes. The surface functionalized affinity membranes can provide increased binding capacity through improved coupling chemistries, ligand densities, spacer arm types, and spacer arm lengths. Methods of preparing the surface functionalized affinity membranes and methods of using the surface functionalized affinity membranes to isolate targets of interest, including nucleic acid molecules and proteins, from a sample are also provided. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937251 |
| CURRENT CPC | Separation B01D 15/3828 (20130101) Original (OR) Class B01D 67/0002 (20130101) B01D 67/00931 (20220801) B01D 69/02 (20130101) B01D 69/144 (20130101) B01D 69/1071 (20220801) B01D 2323/36 (20130101) B01D 2325/12 (20130101) B01D 2325/36 (20130101) B01D 2325/38 (20130101) B01D 2325/42 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/3255 (20130101) B01J 20/3274 (20130101) B01J 20/28038 (20130101) B01J 2220/54 (20130101) B01J 2220/80 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54353 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149923 | Hui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elliot En-Yu Hui (Irvine, California); Hinesh Vipul Patel (Irvine, California) |
| ABSTRACT | The present invention is directed to the fabrication and use of phase-change material (PCM) membranes in microvalves for microfluidic systems. The microvalve may be fabricated by using a tissue-sectioning instrument to slice a thin membrane of PCM off of a block of PCM. The membrane may then be sandwiched between a plurality of microfluidic flow sections to act as a microvalve. At room temperature, the membrane may exist in a solid state to act as a zero-leakage seal and microvalve. Applying heat to the membrane may bring the membrane to a melting point, causing it to reach a liquid state. The microvalve in the liquid state may experience a surface tension effect by a material of the microfluidic flow sections, causing it to displace from a flow path and allow a fluid to pass from one microfluidic flow section to another. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/995842 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 2200/0689 (20130101) B01L 2300/0861 (20130101) B01L 2400/0677 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150192 | Sant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); Technical University of Munich (Munich, Germany); Master Builders Construction Chemicals (Beachwood, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav Sant (Los Angeles, California); Sharu Bhagavathi Kandy (Los Angeles, California); Torben Gädt (Traunstein, Germany); Iman Mehdipour (Los Angeles, California); Thiyagarajan Ranganathan (Los Angeles, California); Samanvaya Srivastava (Los Angeles, California); Paul Seiler (Aurora, Ohio) |
| ABSTRACT | A thermoresponsive suspension composition for use in additive manufacturing includes an aqueous suspension of a thermosetting resin, a crosslinking agent configured to react with the thermosetting resin, and a mineral particulate, wherein the thermosetting resin and crosslinking agent react at or above a trigger temperature. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529763 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/245 (20130101) C08G 59/4064 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/26 (20130101) C08K 3/36 (20130101) C08K 5/3445 (20130101) C08K 2003/265 (20130101) Compositions of Macromolecular Compounds C08L 63/00 (20130101) C08L 2201/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230150943 | Goodson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Boyd M. Goodson (Carbondale, Illinois); Eduard Y. Chekmenev (Troy, Michigan); Bryce E. Kidd (Carbondale, Illinois); Jamil A. Mashni (Carbondale, Illinois); Miranda Limbach (Creal Springs, Illinois); Yuqing Hou (Carbondale, Illinois); Fan Shi (Houston, Texas) |
| ABSTRACT | The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/149740 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/12 (20130101) B01J 2531/827 (20130101) Heterocyclic Compounds C07D 213/46 (20130101) C07D 213/63 (20130101) C07D 233/60 (20130101) Original (OR) Class C07D 241/12 (20130101) C07D 401/06 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6506 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) G01R 33/282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151062 | FOX et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerome FOX (Boulder, Colorado); Ankur SARKAR (Boulder, Colorado); Akarawin HONGDUSIT (Boulder, Colorado); Edward KIM (Oakland, California) |
| ABSTRACT | This invention relates to the field of genetic engineering. Specifically, the invention relates to the construction of operons to produce biologically active agents. For example, operons may be constructed to produce agents that control the function of biochemical pathway proteins (e.g., protein phosphatases, kinases and/or proteases). Such agents may include inhibitors and modulators that may be used in studying or controlling phosphatase function associated with abnormalities in a phosphatase pathway or expression level. Fusion proteins, such as light activated protein phosphatases, may be genetically encoded and expressed as photoswitchable phosphatases. Systems are provided for use in controlling phosphatase function within living cells or in identifying small molecule inhibitors/activator/modulator molecules of protein phosphatases associated with cell signaling. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816937 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/47 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Enzymes C12Y 205/0101 (20130101) C12Y 205/01001 (20130101) C12Y 207/01036 (20130101) C12Y 207/04002 (20130101) C12Y 301/01048 (20130101) C12Y 401/01033 (20130101) C12Y 402/03017 (20130101) C12Y 402/03018 (20130101) C12Y 402/03024 (20130101) C12Y 402/03056 (20130101) C12Y 503/03002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151128 | CABANERO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DAVID C. CABANERO (New York, New York); TOMISLAV ROVIS (New York, New York) |
| ABSTRACT | Exemplary methods, catalysts, catalyst compositions and systems are provided to activate a latent ruthenium olefin metathesis catalyst using a deep red to near infrared light (e.g., 600-800 nm) in conjunction with an osmium (II) photocatalyst that is directly excited to its triplet state via spin-forbidden excitation. An excited state single electron reduction of a latent solvent coordinated, cationic pre-catalyst is proposed as the operating mechanism for activation and photocontrol, as probed via in situ LED NMR kinetic studies and cyclic voltammetry. Excellent levels of spatiotemporal control can be found under light irradiation. NIR olefin metathesis exhibits improved light penetration through barriers over lower wavelengths of light, a control element that was deployed to mold dicyclopentadiene via Ring Opening Metathesis Polymerization (ROMP). |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977146 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/46 (20130101) C08F 4/80 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151211 | Hallinan, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Hallinan, Jr. (Tallahassee, Florida); Justin G. Kennemur (Tallahassee, Florida); Karen I. Winey (Philadelphia, Pennsylvania); Benjamin A. Paren (Philadelphia, Pennsylvania); Kyoungmin Kim (Sandy, Utah); Michael Patrick Blatt (Tallahassee, Florida) |
| ABSTRACT | Polymer blends that may be used as electrolytes. Devices that include polymer blends. Methods of forming polymer blends. The polymer blends may include a polysolvent and a polymer, such as a polymer that includes a negatively charged sidechain. The devices may include a lithium ion battery. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 18/056562 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 71/02 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0565 (20130101) H01M 2300/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151354 | FOX et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerome FOX (Boulder, Colorado); Ankur SARKAR (Boulder, Colorado) |
| ABSTRACT | The disclosure provides systems, methods, reagents, apparatuses, vectors, and host cells for the discovery and evolution of metabolic pathways that produce small molecules that modulate enzyme function. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859509 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 15/52 (20130101) C12N 15/70 (20130101) C12N 15/1055 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/007 (20130101) Enzymes C12Y 205/01029 (20130101) C12Y 402/03017 (20130101) C12Y 402/03018 (20130101) C12Y 402/03038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151405 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong WANG (State College, Pennsylvania); Brandon J. DAVIS (State College, Pennsylvania); Peng SHI (State College, Pennsylvania) |
| ABSTRACT | The present invention provides methods for signal amplification. The methods use DNA hybridization chain reaction to build labeled nanoscaffolds off of target analytes. The methods are reversible, as the detectable signal can be removed using DNA hybridization and hydrolysis. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/919225 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/5308 (20130101) G01N 2458/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151576 | FROST et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James David FROST (Atlanta, Georgia); John A. HUNTOON (Atlanta, Georgia); Seth D. MALLETT (Atlanta, Georgia) |
| ABSTRACT | Various implementations include a ground anchoring apparatus including a longitudinal body, first and second retaining members, and a set of expanding linkage assemblies. The first retaining member is rigidly coupled to the longitudinal body. The second retaining member is movably coupled to the longitudinal body. Each expanding linkage assembly includes first and second linkage members. The first linkage member has first and second portions, and the second linkage member has third and fourth portions. The first portion is rotatably coupled to the first retaining member. The fourth portion is rotatably coupled to the second retaining member. The third portion is rotatably coupled to the second portion. The set of expanding linkage assemblies is movable between a collapsed and expanded configuration. The second retaining member is closer to the first retaining member and the third portion is further from the central axis in the expanded configuration than in the collapsed configuration. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/915900 |
| CURRENT CPC | Foundations; Excavations; Embankments; Underground or Underwater Structures E02D 5/803 (20130101) Original (OR) Class E02D 2600/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152230 | FAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Xudong FAN (Ann Arbor, Michigan); Qiushu CHEN (San Bruno, California); Yunlu SUN (Ann Arbor, Michigan) |
| ABSTRACT | The present disclosure provides an imaging system. The imaging system may include a laser cavity that is configured to receive a biological sample, where the biological sample is treated with a dye; an excitation light source that is configured to direct energy at the laser cavity so as to cause an emission from the biological sample, where the emission includes a laser emission at a first spectral band and a fluorescence emission at a second spectral band; a first detector that is configured to measure the laser emission generated by the biological sample; a second detector that is configured to measure the fluorescence emission generated by the biological sample; a splitter that is configured to direct the laser emission to the first detector and the fluorescence emission to the second detector; and a controller interfaced with the excitation light source, the first detector, and the second detector. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/919671 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) Original (OR) Class G01N 2021/6421 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152329 | Ghosh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Indraneel Ghosh (Tucson, Arizona); Matthew Bienick (Tucson, Arizona); Sean Campbell (Bronx, New York); Carl Buchholz (Roanoke, Virginia) |
| ABSTRACT | A method to produce novel split-protein sensors are described herein. The method implements a sequence dissimilarity (SD) based design that can identify potential split-sites in proteins to generate a split-protein pair, and then employs structure guided mutagenesis of the fragmented protein interface to generate split-protein sensors. The sensors have a signal to background ratio >200 and can be readily used to monitor protein-protein interactions and their inhibition in cells. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/905675 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/66 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152672 | Bidwell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Circle Optics, Inc. (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Bidwell (Bergen, New York); Christopher M. Muir (Rochester, New York); Eugene Sisto (Rochester, New York); Andrew F. Kurtz (Macedon, New York); Allen Krisiloff (Rochester, New York); John Bowron (Burlington, Canada); Zakariya Niazi (Rochester, New York); Robert Stanchus (Wolcott, New York); James Mazzarella (Fairport, New York); Robert Baldino (Spencerport, New York); Deanan DaSilva (Playa del Rey, California); Jose Manuel Sasian-Alva (Tucson, Arizona); Charles E. Brugger (Webster, New York) |
| ABSTRACT | A low parallax imaging device includes a plurality of imaging lens elements arranged to capture adjacent fields of view. In some examples, adjacent imaging lens elements may contact at datum features to maintain a desired spacing. The spacing may allow for partial overlapping of low-parallax volumes associated with the respective imaging lens elements. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/908158 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 7/14 (20130101) G02B 13/06 (20130101) G02B 27/0025 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 17/14 (20130101) Original (OR) Class G03B 17/561 (20130101) G03B 37/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153287 | Stephens et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AirMettle, Inc. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donpaul C. Stephens (Houston, Texas); Joshua R. Fuhs (Columbus, Indiana) |
| ABSTRACT | A technique of partitioning compressed data includes splitting the compressed data into multiple portions. The technique further includes storing a decompression state in association with a current portion, wherein the decompression state is based on data of a previous portion and enables decompression of the current portion independently of other portions. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 17/978609 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/278 (20190101) G06F 16/1744 (20190101) G06F 16/2282 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153676 | Freedman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danna E. Freedman (Evanston, Illinois); David D. Awschalom (Chicago, Illinois); Dan W. Laorenza (Evanston, Illinois); Majed S. Fataftah (New Haven, Connecticut); Sam L. Bayliss (Chicago, Illinois); Berk Diler (Chicago, Illinois); Peter J. Mintun (Chicago, Illinois) |
| ABSTRACT | A molecular-spin qubit is formed from a coordination complex having a plurality of strong-field ligands bound to a metal-atom center. The ground state has non-zero spin, and the resulting ground-state magnetic sublevels are separated by microwave or millimeter-wave frequencies, even in the absence of an external field. Two of these sublevels may be used as a quantum resource for quantum information processing, quantum communication, quantum memory, sensing, and other applications. Optical pumping to an excited state may be used to spin-polarize the molecular-spin qubit, and to measure its population by detecting photoluminescence. The energy-level structure of the metal-atom center can be modified due to its interaction with the ligands, therefore allowing the molecular-spin qubit to be “chemically tuned” based on the number and type of ligands. Ensembles of these molecular-spin qubits can be controllably deposited on a surface, or otherwise integrated into devices and structures. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/995825 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/2208 (20130101) C07F 11/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230153692 | Hong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingyi Hong (Wayzata, Minnesota); Haoran Sun (Bellevue, Washington); Xiao Fu (Albany, Oregon) |
| ABSTRACT | A wireless communication system includes memory configured to store a model for predicting one or more parameters of the system, and one or more processors configured to: receive samples of the wireless communication system over a plurality of sequential batches, each of the batches represents a different, non-overlapping period of time; for each of the batches: select, based on a sample selection criteria, a subset of the samples from a first batch as representative samples for the first batch, wherein the sample selection criteria is based on a system performance metric computed for each of the samples; store the subset of the samples for one or more of the sequential batches in the memory; and upon receiving samples for a second batch, train the model to predict the one or more parameters using the samples from the second batch and the subset of the samples stored in the memory. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054479 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154178 | Krista |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larisza D. Krista (Erie, Colorado) |
| ABSTRACT | A system for forecasting when solar flares will occur and identifying their possible locations creates a mask to analyze an image of a solar disk. The system also creates an intensity histogram using the solar disk. Additionally, the system stores a resulting full-disk image and a sub-image identifying possible flare signature sites. Further, the system applies a method to filter out false positive detections by using an equation that enhances true positive pre-flare signatures and minimizes false positive signatures. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 17/985727 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/22 (20220101) G06V 10/36 (20220101) G06V 20/13 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154465 | KELLY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate (DENVER, Colorado) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate (DENVER, Colorado) |
| INVENTOR(S) | SEAN P. KELLY (PITTSBURGH, Pennsylvania); SIDNEY D'MELLO (BOULDER, Colorado) |
| ABSTRACT | A method of analyzing instructor discourse includes recording an audio signal representing speech of the instructor during a class session, converting the audio signal to a session transcript comprising speech data for the session using an automatic speech recognition tool and segmenting the transcript into utterances, extracting a set of features from the session transcript, filtering student talk out from the utterances, analyzing a first subset of the features to produce a number of local context predictions for each utterance of the session transcript, analyzing a second subset of the features to produce a number of global context predictions for the session transcript, and combining a subset of the number of local context predictions and the number of global context predictions into a classification that attends to differential reliability. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/917429 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/01 (20130101) G10L 15/26 (20130101) Original (OR) Class G10L 21/0272 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154561 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianlin Cheng (Columbia, Missouri); Elham Soltanikazemi (Columbia, Missouri); Raj Shekhor Roy (Columbia, Missouri); Farhan Quadir (Columbia, Missouri) |
| ABSTRACT | Deep learning systems and methods for predicting structural aspects of protein-related complexes are described herein. An example method for predicting inter-chain distances of protein-related complexes includes receiving data associated with a protein-related complex, where the data associated with the protein-related complex includes at least one of a tertiary structural feature and a multiple sequence alignment (MSA)-derived feature. The method also includes inputting the data associated with the protein-related complex into a deep learning model. The method further includes predicting, using the deep learning model, an inter-chain distance map for the protein-related complex. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 17/988461 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/045 (20230101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) G16B 15/30 (20190201) Original (OR) Class G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154641 | Watkins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | James Watkins (South Hadley, Massachusetts); Michael R. Beaulieu (Chicopee, Massachusetts); Nicholas R. Hendricks (South Deerfield, Massachusetts) |
| ABSTRACT | Aspects relate to patterned nanostructures having a feature size not including film thickness of below 5 microns. The patterned nanostructures are made up of nanoparticles having an average particle size of less than 100 nm. A nanoparticle composition, which, in some cases, includes a binder, is applied to a substrate. A patterned mold used in concert with electromagnetic radiation function to manipulate the nanoparticle composition in forming the patterned nanostructure. In some embodiments, the patterned mold nanoimprints a pattern onto the nanoparticle composition and the composition is cured through UV or thermal energy. Three-dimensional patterned nanostructures may be formed. A number of patterned nanostructure layers may be prepared and joined together. In some cases, a patterned nanostructure may be formed as a layer that is releasable from the substrate upon which it is initially formed. Such releasable layers may be arranged to form a three-dimensional patterned nanostructure for suitable applications. |
| FILED | Thursday, January 19, 2023 |
| APPL NO | 18/098804 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/118 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/08 (20130101) Original (OR) Class H01B 3/10 (20130101) H01B 13/003 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/04 (20130101) H01M 6/40 (20130101) H01M 8/124 (20130101) Organic electric solid-state devices H10K 71/211 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154736 | Jarrold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. Jarrold (Bloomington, Indiana); Andrew W. Alexander (Bloomington, Indiana); Aaron R. Todd (Bloomington, Indiana) |
| ABSTRACT | A CDMS may include an ion source to generate ions from a sample, a mass spectrometer to separate the generated ions as a function of ion mass-to-charge ratio, an electrostatic linear ion trap (ELIT) having a charge detection cylinder disposed between first and second ion mirrors, wherein ions exiting the mass spectrometer are supplied to the ELIT, a charge generator for generating free charges, a field free region between the charge generator and the charge detection cylinder, and a processor configured to control the charge generator, with no ions in the charge detection cylinder, to generate a target number of free charges and cause the target number of free charges to travel across the field-free region and into contact with the charge detection cylinder to deposit the target number of free charges thereon and thereby calibrate or reset the charge detection cylinder to a corresponding target charge level. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/149743 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0009 (20130101) H01J 49/022 (20130101) H01J 49/025 (20130101) Original (OR) Class H01J 49/4245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230154741 | JARROLD et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. JARROLD (Bloomington, Indiana); Daniel BOTAMANENKO (Bloomington, Indiana) |
| ABSTRACT | A charge detection mass spectrometer may include an ion source to generate ions, a mass spectrometer to separate the generated ions as a function of ion mass-to-charge ratio to produce beam of separated ions, an electrostatic linear ion trap (ELIT) including a charge detection cylinder disposed between a pair of coaxially aligned ion mirrors, and means for controlling a trajectory of the beam of separated ions entering the ELIT to cause the ions subsequently trapped in the ELIT to oscillate therein with different planar ion oscillation trajectories angularly offset from one another about the longitudinal axis with each extending along and crossing the longitudinal axis in each of the ion mirrors or with different cylindrical ion oscillation trajectories radially offset from one another about the longitudinal axis to form nested cylindrical trajectories each extending along the longitudinal axis. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/146768 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/623 (20210101) Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) H01J 49/025 (20130101) H01J 49/426 (20130101) H01J 49/482 (20130101) H01J 49/4245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155090 | VISELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yon VISELL (Goleta, California); Shantonu BISWAS (Santa Barbara, California) |
| ABSTRACT | A method of manufacturing a stretchable electronic device includes the steps of: a) depositing a release layer on a temporary rigid substrate; b) depositing a sacrificial layer on the release layer; c) fabricating conductive traces and electrical contacts on top of the sacrificial layer; d) mounting surface mount components (SMCs) to the electrical contacts; e) depositing a first stretchable polymer layer over the conductive traces and SMCs to form a stretchable substrate; f) separating the rigid substrate and release layer from the sacrificial layer and the stretchable substrate at an interface between the release layer and the sacrificial layer; g) removing the sacrificial layer from the stretchable substrate; and h) depositing a second stretchable polymer layer on a surface of the stretchable substrate exposed by removing the sacrificial layer. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/798325 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 25/167 (20130101) H01L 33/005 (20130101) H01L 33/44 (20130101) H01L 33/62 (20130101) Original (OR) Class H01L 2933/0025 (20130101) H01L 2933/0066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155136 | Smith |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Kyle Christopher Smith (Champaign, Illinois) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, a porous device, comprising a porous material, and a hierarchical network of flow channels defined in the porous material, wherein at least one flow channel in the hierarchical network of flow channels has a shape that at least partially approximates a cube-root profile or a quartic-root profile. Additional embodiments are disclosed. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980023 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8626 (20130101) Original (OR) Class H01M 4/8878 (20130101) H01M 8/0258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155371 | Mysore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pratap Gopal Mysore (Plymouth, Minnesota); Daniel Kelly (St. Paul, Minnesota); Ned Mohan (St. Paul, Minnesota) |
| ABSTRACT | A method is provided for operating an inverter of an inverter-based power resource providing electric power to a grid through one or more transformers. The method includes measuring voltages associated with terminals on a selected primary winding and/or measuring voltages associated with terminals on a selected secondary winding; and injecting currents into the primary terminals of the selected primary winding during a fault condition based on the measured voltages being indicative of the type of fault occurring. Preferably the inverter is operated to emulate at least some characteristics of fault currents provided by a generator having rotating magnets or electrical windings. An apparatus is configured to operate in accordance with the method and includes an electrical switching device circuit having input terminals for an inverter-based power resource and output terminals for providing AC electric power to an electric power grid. An inverter controller operates the electrical switching device circuit. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/917112 |
| CURRENT CPC | Emergency Protective Circuit Arrangements H02H 3/40 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/539 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230157144 | LIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lih-Yuan LIN (Seattle, Washington); Chen ZOU (Seattle, Washington); Ethan G. KEELER (Seattle, Washington) |
| ABSTRACT | A method includes forming a barrier layer on a substrate, removing a portion of the barrier layer to yield a patterned barrier layer and an exposed portion of the substrate within a hole in the patterned barrier layer, forming a first portion of a perovskite on the patterned barrier layer and a second portion of the perovskite on the exposed portion of the substrate, and removing the patterned barrier layer, thereby removing the first portion of the perovskite. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/915819 |
| CURRENT CPC | Organic electric solid-state devices H10K 59/35 (20230201) H10K 71/15 (20230201) H10K 71/211 (20230201) Original (OR) Class H10K 85/50 (20230201) H10K 85/111 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230149146 | GIORDANO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julio GIORDANO (Ithaca, New York); David ERICKSON (Ithaca, New York); Yue REN (Ithaca, New York); Magdalena Masello SOUZA (Washington, District of Columbia) |
| ABSTRACT | An automated controlled device for livestock management and methods of use thereof. The device includes a housing configured to be inserted into a body cavity. One or more reservoirs are configured to be located within the housing and to store a fluid. One or more pumps are coupled to the one or more reservoirs. The one or more pumps are configured to deliver fluid stored in the one or more reservoirs to an area external to the housing during use. A microcontroller is coupled to the one or more pumps. The microcontroller is configured to operate the one or more pumps to deliver a predetermined volume of the fluid stored in the one or more reservoirs to the area external to the housing at a scheduled time |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/920475 |
| CURRENT CPC | Veterinary Instruments, Implements, Tools, or Methods A61D 19/022 (20130101) A61D 19/027 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2205/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149528 | Rieder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Triad National Security, LLC (LOS ALAMOS, New Mexico); KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (MANHATTAN, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aida E. Rieder (WESTBROOK, Connecticut); KATHERINE M. PFLAUM (MIDDLETOWN, Connecticut); FAYNA C. DIAZ SAN SEGUNDO (BLUE POINT, New York); WILLIAM M. FISCHER (LOS ALAMOS, New Mexico); TATJANA SITT (ESSEX, Connecticut) |
| ABSTRACT | Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype O FMDV strains. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/889737 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/135 (20130101) Original (OR) Class A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152232 | KIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MOON S. KIM (ASHTON, Maryland); JIANWEI QIN (ELLICOTT CITY, Maryland); DIANE E. CHAN (ODENTON, Maryland); LYNDEL MEINHARDT (COLLEGE PARK, Maryland); INSUCK BAEK (BURTONSVILLE, Maryland); KENNETH BARTON (PALM CITY, Florida); FARTASH VASEFI (SHERMAN OAKS, California) |
| ABSTRACT | The contamination sanitation inspection system (CSIS) allows a user to capture an image of a large scene (such as a food processing line, a food service facility, a food products storage area, or a plant production area/facility) and identify contamination within the scene and preferably represent the contamination on a spatially accurate map (or floorplan) so that contamination within the inspection map area is clearly identified and recorded for subsequent treatment. In an alternative embodiment, the CSIS also includes a decontamination system to sanitize any identified contamination. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/529019 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/10 (20130101) A61L 2/28 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/94 (20130101) G01N 21/6486 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230149248 | Walker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Walker (Shaker Heights, Ohio); Michael Fu (Mayfield Heights, Ohio) |
| ABSTRACT | Methods and systems for dynamically prescribing therapeutic games for treatment of ocular disorder are disclosed. The methods and systems include: performing an eye position calibration technique in a virtual reality environment to calibrate the virtual reality environment to a user; performing an eye movement measurement to produce a diagnosis result; selecting a virtual reality therapeutic game based on the diagnosis result; performing the virtual reality therapeutic game to receive a game user input in the virtual reality therapeutic game; and dynamically adjusting difficulty of the virtual reality therapeutic game based on the game user input. Other aspects, embodiments, and features are also claimed and described. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 18/056249 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 5/00 (20130101) Original (OR) Class A61H 5/005 (20130101) A61H 2201/1604 (20130101) A61H 2201/5007 (20130101) A61H 2201/5043 (20130101) A61H 2230/00 (20130101) Card, Board, or Roulette Games; Indoor Games Using Small Moving Playing Bodies; Video Games; Games Not Otherwise Provided for A63F 13/67 (20140902) A63F 13/213 (20140902) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230149469 | Frank et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Markus H. Frank (Cambridge, Massachusetts); Natasha Y. Frank (Cambridge, Massachusetts); Dennis P. Orgill (Belmont, Massachusetts); George F. Murphy (Boston, Massachusetts) |
| ABSTRACT | The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947360 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 38/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/3834 (20130101) A61L 27/3886 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/063 (20130101) C12N 5/0668 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230151071 | Sathyanesan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); UNIVERSITY OF SOUTH DAKOTA (Vermillion, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Newton Sathyanesan (Vermillion, South Dakota); Monica Sathyanesan (Vermillion, South Dakota); Jason Petersen (Washington, District of Columbia) |
| ABSTRACT | Disclosed are polypeptides comprising an engineered recombinant EPO. For example, disclosed are polypeptides comprising the sequence of SEQ ID NO: 1. Disclosed are variant Epo polypeptides comprising three amino acid substitutions at positions 20, 45 and 97 of wild type human Epo. Disclosed are polynucleotides comprising a nucleic acid capable of encoding one or more of the disclosed polypeptides. Disclosed are vectors comprising any of the polynucleotides disclosed herein. Disclosed are compositions comprising the disclosed polypeptides, polynucleotides or vectors. Disclosed are cells comprising one or more of the disclosed polypeptides, one or more of the disclosed polynucleotides, and/or one or more of the disclosed vectors. Disclosed are methods of using a therapeutically effective amount of one or more of the disclosed polypeptides, nucleic acids or vectors to a subject in need thereof. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/917264 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/505 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230150663 | McCall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ATA, LLC (Vienna, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Micaela McCall (Albuquerque, New Mexico); Boris Boiko (Baltimore, Maryland); Matthew Scott Drew (Alexandria, Virginia); John S. Eberhardt, III (Vienna, Virginia); Mitchell Horning (Reston, Virginia); James Hughes (Austin, Texas); Eric Kucks (Annandale, Virginia); Cameron Peterson (Logan, Utah); Zack Radeka (Reston, Virginia); Emily Richards (St. Charles, Missouri) |
| ABSTRACT | A method includes receiving a first navigation path risk request that includes first navigation path information associated with a first navigation path for a first unmanned vehicle through a first environment. The method also includes selecting a first risk model from a plurality of risk models based on the first navigation path information. The method also includes obtaining first data used as one or more inputs to run the first risk model from one or more data sources. The method also includes operating the first risk model with the first data to output a first risk score. The method also includes providing a first navigation path risk response in response to the first navigation path risk request that includes the first risk score that is associated with at least a portion of the first navigation path. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947549 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Original (OR) Class B64C 2201/145 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230152008 | Brewer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Blueshift, LLC dba Outward Technologies (Broomfield, Colorado) |
| ASSIGNEE(S) | Blueshift, LLC dba Outward Technologies (Broomfield, Colorado) |
| INVENTOR(S) | Andrew Timon Brewer (Wheat Ridge, Colorado); Ryan Garvey (Lafayette, Colorado); Alan Thomas Carter (Arvada, Colorado); Austin Kenneth Miller (Niwot, Colorado); Troy Southard (Edgewater, Colorado) |
| ABSTRACT | A solar energy particle receiver system and method of use for precise and controlled heating, sintering, and/or phase change of particles. In one embodiment, the solar energy particle receiver system directs sunlight from a primary concentrator into supplemental concentrating reflective optic where the emitted sunlight is used to heat and sinter, melt, or induce a phase change of the particles such as regolith at a controlled temperature, the supplemental concentrating reflective optics cooled to prevent overheating and a sweeping gas directed at the reflective surface to prevent optical fouling. In one aspect, the supplemental concentrating reflective optic is a compound reflective concentrator. In one application, the particles are a regolith, such as a lunar regolith. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/983266 |
| CURRENT CPC | Solar Heat Collectors; Solar Heat Systems F24S 23/71 (20180501) F24S 40/55 (20180501) F24S 50/80 (20180501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155545 | Bolisay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | L'Garde, Inc. (Tustin, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linden Bolisay (Las Vegas, Nevada); Arthur Palisoc (Tustin, California) |
| ABSTRACT | Exemplary embodiments described herein may include lightweight, low stow volume solar concentrator. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/929275 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 99/00 (20220801) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/22 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230149528 | Rieder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Triad National Security, LLC (LOS ALAMOS, New Mexico); KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (MANHATTAN, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aida E. Rieder (WESTBROOK, Connecticut); KATHERINE M. PFLAUM (MIDDLETOWN, Connecticut); FAYNA C. DIAZ SAN SEGUNDO (BLUE POINT, New York); WILLIAM M. FISCHER (LOS ALAMOS, New Mexico); TATJANA SITT (ESSEX, Connecticut) |
| ABSTRACT | Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype O FMDV strains. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/889737 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/135 (20130101) Original (OR) Class A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230156465 | Boyd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Daniel A. Boyd (Arlington, Virginia); Kelli L. Biegger (Fort Worth, Texas); Chang Ellison (Arlington, Virginia); Brandon P. Gutierrez (Johns Creek, Georgia); Jason Lim (Alexandria, Virginia); William Washington (North Potomac, Maryland) |
| ABSTRACT | A vehicle information remote retrieval method includes an emergency personnel or first responder vehicle (FRV) establishing a vehicle connection between an infotainment system of a vehicle and the FRV. The FRV sends a vehicle information request to the infotainment system of the vehicle, via the vehicle connection, seeking release of vehicle information. The FRV obtains authentication of the vehicle information received in response to the vehicle information request. The FRV determines occupant status based on the vehicle information. The FRV communicates the passenger status to a first responder. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100040 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10 (20130101) Wireless Communication Networks H04W 4/46 (20180201) H04W 12/02 (20130101) H04W 12/04 (20130101) Original (OR) Class H04W 12/08 (20130101) H04W 12/033 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230150663 | McCall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ATA, LLC (Vienna, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Micaela McCall (Albuquerque, New Mexico); Boris Boiko (Baltimore, Maryland); Matthew Scott Drew (Alexandria, Virginia); John S. Eberhardt, III (Vienna, Virginia); Mitchell Horning (Reston, Virginia); James Hughes (Austin, Texas); Eric Kucks (Annandale, Virginia); Cameron Peterson (Logan, Utah); Zack Radeka (Reston, Virginia); Emily Richards (St. Charles, Missouri) |
| ABSTRACT | A method includes receiving a first navigation path risk request that includes first navigation path information associated with a first navigation path for a first unmanned vehicle through a first environment. The method also includes selecting a first risk model from a plurality of risk models based on the first navigation path information. The method also includes obtaining first data used as one or more inputs to run the first risk model from one or more data sources. The method also includes operating the first risk model with the first data to output a first risk score. The method also includes providing a first navigation path risk response in response to the first navigation path risk request that includes the first risk score that is associated with at least a portion of the first navigation path. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947549 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Original (OR) Class B64C 2201/145 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230155168 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bioenno Tech LLC (Santa Ana, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhigang Lin (Santa Ana, California); Chunhu Tan (Santa Ana, California); Tianyu Meng (Santa Ana, California) |
| ABSTRACT | Electrolyte-infiltrated composite electrode includes an electrolyte component consisting of a polymer matrix with ceramic nanoparticles embedded in the matrix to form a networking structure of electrolyte. Suitable ceramic nanoparticles have the basic formula Li7La3Zr2O12 (LLZO) and its derivatives such as AlxLi7-xLa3Zr2-y-zTayNbzO12 where x ranges from 0 to 0.85, y ranges from 0 to 0.50 and z ranges from 0 to 0.75, wherein at least one of x, y and z is not equal to 0. The networking structure of the electrolyte establishes an effective lithium-ion transport pathway in the electrode and strengthens the contact between electrode layer and solid-state electrolyte resulting in higher lithium-ion electrochemical cell's cycling stability and longer battery life. Sold-state electrolytes incorporating the ceramic particles demonstrate improved performance. Large dimensional electrolyte-infiltrated composite electrode sheets can be used in all solid-state lithium electrochemical pouch cells which can be assembled into battery packs. |
| FILED | Monday, January 16, 2023 |
| APPL NO | 18/097384 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2004/021 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20230149855 | Sirkar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey); Applied Membrane Technology, Inc. (Minnetonka, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kamalesh Sirkar (Bridgewater, New Jersey); Dhananjay Singh (Kearny, New Jersey); Lin Li (Kearny, New Jersey); Thomas J. McEvoy (Tofte, Minnesota) |
| ABSTRACT | Exemplary embodiments in desalination by direct contact membrane distillation present a cylindrical cross-flow module containing high-flux composite hydrophobic hollow fiber membranes. The present embodiments are directed to a model that has been developed to describe the observed water production rates of such devices in multiple brine feed introduction configurations. The model describes the observed water vapor production rates for different feed brine temperatures at various feed brine flow rates. The model flux predictions have been explored over a range of hollow fiber lengths to compare the present results with those obtained earlier from rectangular modules which had significantly shorter hollow fibers. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/085724 |
| CURRENT CPC | Separation B01D 61/364 (20130101) B01D 61/366 (20130101) Original (OR) Class B01D 63/04 (20130101) B01D 2313/10 (20130101) B01D 2313/12 (20130101) B01D 2313/21 (20130101) B01D 2315/10 (20130101) B01D 2325/38 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/447 (20130101) C02F 2103/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, May 18, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
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https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230518.html
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