FedInvent™ Patent Applications
Application Details for Thursday, May 25, 2023
This page was updated on Thursday, May 25, 2023 at 12:28 PM GMT
Department of Health and Human Services (HHS)
| US 20230157622 | Mannoh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emmanuel A. Mannoh (Nashville, Tennessee); Anita Mahadevan-Jansen (Nashville, Tennessee) |
| ABSTRACT | One aspect of the invention relates to a method for intraoperative detection of parathyroid gland viability in a surgery, comprising obtaining speckle contrast images of a parathyroid gland of a patent; and displaying the speckle contrast images of the parathyroid gland in real-time. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/065707 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/0075 (20130101) A61B 5/0086 (20130101) A61B 5/415 (20130101) Original (OR) Class A61B 5/418 (20130101) A61B 5/742 (20130101) A61B 5/4227 (20130101) A61B 34/20 (20160201) A61B 2034/2055 (20160201) A61B 2505/05 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 21/6456 (20130101) G01N 2021/6439 (20130101) G01N 2201/0221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230157658 | Dey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Damini Dey (Los Angeles, California); Sebastien Cadet (Los Angeles, California); Piotr Slomka (Los Angeles, California); Rajendra Makkar (Beverly Hills, California) |
| ABSTRACT | Calcific and noncalcific aortic tissue components can be quantified. Pre-intervention planning computed tomography angiography imaging data is received. A region of interest is defined between the lower coronary ostium and the virtual basal ring. Cross-sectional images of the region of interest are rendered and calcific and noncalcific tissue components are identified based on Hounsfield unit thresholds. The volumes of the identified calcific and noncalcific tissue components are calculated and used to determine a total tissue volume (e.g., fibrocalcific volume) for the valve, as well as component percentages of the total tissue volume for the calcific and noncalcific components. These volumes and/or component percentages can be leveraged to predict severe AS, identify prognosis of post-TAVI outcomes, or otherwise facilitate planning of medical intervention. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993819 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/504 (20130101) Original (OR) Class A61B 6/5217 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230157755 | KIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); University of Maryland (College Park, Maryland); Children's National Hospital (Washington, District of Columbia) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Byeol KIM (College Park, Maryland); Xiaolong LIU (College Park, Maryland); Axel KRIEGER (Alexandria, Virginia); Mark D. FUGE (College Park, Maryland); Phong Danh NGUYEN (College Park, Maryland); Rachel HESS (College Park, Maryland); Pratham Vijay NAR (College Park, None); Laura OLIVIERI (Washington, District of Columbia); Narutoshi HIBINO (Baltimore, Maryland); Yue-Hin LOKE (Washington, District of Columbia); Paige MASS (Washington, District of Columbia); Seda ASLAN (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods of generating optimized models of vascular grafts for subjects in certain embodiments. Methods of treating subjects in need of vascular grafts are also provided. Related systems and computer program products are additionally provided. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/906798 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) Original (OR) Class A61B 2034/102 (20160201) A61B 2034/108 (20160201) Image Data Processing or Generation, in General G06T 7/149 (20170101) G06T 19/20 (20130101) G06T 2207/10088 (20130101) G06T 2207/30104 (20130101) G06T 2219/2004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230157961 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter X. Ma (Ann Arbor, Michigan); Ming Dang (Maple Grove, Minnesota); Laurie K. McCauley (Ann Arbor, Michigan) |
| ABSTRACT | In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099810 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/204 (20130101) A61K 9/205 (20130101) A61K 9/2031 (20130101) Original (OR) Class A61K 9/5031 (20130101) A61K 9/7007 (20130101) A61K 38/29 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230157965 | Popov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexey Popov (Waltham, Massachusetts); Elizabeth M. Enlow (Waltham, Massachusetts); James Bourassa (Somerville, Massachusetts); Colin R. Gardner (Concord, Massachusetts); Hongming Chen (Belmont, Massachusetts); Laura M. Ensign (Towson, Maryland); Samuel K. Lai (Carrboro, North Carolina); Tao Yu (Baltimore, Maryland); Justin Hanes (Baltimore, Maryland); Ming Yang (Towson, Maryland) |
| ABSTRACT | Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100363 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/5031 (20130101) Original (OR) Class A61K 9/5089 (20130101) A61K 9/5138 (20130101) A61K 31/12 (20130101) A61K 31/56 (20130101) A61K 31/58 (20130101) A61K 31/341 (20130101) A61K 31/405 (20130101) A61K 31/409 (20130101) A61K 31/496 (20130101) A61K 31/522 (20130101) A61K 31/569 (20130101) A61K 31/573 (20130101) A61K 31/635 (20130101) A61K 31/662 (20130101) A61K 31/675 (20130101) A61K 47/34 (20130101) A61K 49/0089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230157967 | Irvine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); La Jolla Institute for Immunology (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell J. Irvine (Arlington, Massachusetts); Murillo Silva (Lancaster, Massachusetts); Shane Crotty (San Diego, California); Yu Kato (San Diego, California) |
| ABSTRACT | Non-liposome, non-micelle particles formed of a lipid, an additional adjuvant such as a TLR4 agonist, a sterol, and a saponin are provided. The particles are porous, cage-like nanoparticles, also referred to as nanocages, and are typically between about 30 nm and about 60 nm. In some embodiments, the nanocages include or are administered in combination with an antigen. The particles can increase immune responses and are particularly useful as adjuvants in vaccine applications and related methods of treatment. Preferred lipids, additional adjuvants including TLR4 agonists, sterols, and saponins, methods of making the nanocages, and method of using them are also provided. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/151182 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/19 (20130101) A61K 9/51 (20130101) Original (OR) Class A61K 9/141 (20130101) A61K 39/02 (20130101) A61K 39/0011 (20130101) A61K 39/39 (20130101) A61K 2039/55555 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230157978 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chapman University (Orange, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sun Yang (Orange, California); Keykavous Parang (Orange, California); Richard Chamberlin (Irvine, California); Frank L. Meyskens, JR. (Orange, California) |
| ABSTRACT | Apurinic/apuyrimidinic endonuclease 1/Redox Factor-1 (APE/Ref-1) inhibitors are provided along with methods of using the same. The inhibitor has the structure of Formula I: or a pharmaceutically acceptable salt thereof. n is an integer from 4 to 14, X and X′ are each independently H or OH, and Y and Y′ are each independently H or OH. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 17/990401 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158006 | Grammas |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paula Grammas (Lakewood Ranch, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paula Grammas (Lakewood Ranch, Florida) |
| ABSTRACT | The present invention relates to the treatment of neurodegenerative diseases by administering an endothelial interrupter. More specifically, the endothelial interrupter is a direct thrombin inhibitor. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/919264 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4439 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158019 | HERGENROTHER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Paul J. HERGENROTHER (Champaign, Illinois); Jessie PEH (Champaign, Illinois); Matthew BOUDREAU (Newton, Massachusetts) |
| ABSTRACT | The discovery of mutant or fusion kinases that drive oncogenesis, and the subsequent approval of specific inhibitors for these enzymes, has been instrumental in the management of some cancers. However, acquired resistance remains a significant problem in the clinic, limiting the long-term effectiveness of most of these drugs. Herein is demonstrated a strategy to overcome this resistance through drug-induced MEK cleavage (via direct procaspase-3 activation) combined with targeted kinase inhibition. This combination effect is shown to be general across diverse tumor histologies (melanoma, lung cancer, and leukemia) and driver mutations (mutant BRAF or EGFR, fusion kinases EML4-ALK and BCR-ABL). Caspase-3-mediated degradation of MEK kinases results in sustained pathway inhibition and substantially delayed or eliminated resistance in cancer cells in a manner superior to combinations with MEK inhibitors. These data suggest the generality of drug-mediated MEK kinase cleavage as a therapeutic strategy to prevent resistance to targeted anticancer therapies. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/059024 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/495 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/4184 (20130101) A61K 31/4523 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158025 | Lui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Li LUI (Rockville, Maryland); Ya-qin ZHANG (Rockville, Maryland); Surendra KARAVADHI (Rockville, Maryland); Juan MARUGAN (Rockville, Maryland); Matthew HALL (Rockville, Maryland); Min SHEN (Rockville, Maryland); Samarjit PATNAIK (Rockville, Maryland); UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah); NATIONAL INSTITUTES OF HEALTH (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Li Lui (Rockville, Maryland); Ya-qin Zhang (Rockville, Maryland); Surendra Karavadhi (Rockville, Maryland); Juan Marugan (Rockville, Maryland); Matthew Hall (Rockville, Maryland); Min Shen (Rockville, Maryland); Samarjit Patnaik (Rockville, Maryland); Kent Lai (Salt Lake City, Utah); Manshu Tang (Salt Lake City, Utah); Francis G. Whitby (Salt Lake City, Utah); Christopher P. Hill (Salt Lake City, Utah); Bijina Balakrishna (Salt Lake City, Utah) |
| ABSTRACT | Described herein are compounds that inhibit galactokinase (GALK) and other kinases and methods for producing the same. Also described are methods for using Structure-Activity Relationships (SAR) to develop compounds with enhanced activity. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/995519 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class A61K 31/527 (20130101) A61K 31/5377 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158028 | Vergnes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laurent Vergnes (Oakland, California); Karen Reue (Oakland, California) |
| ABSTRACT | The compounds and methods of the present disclosure exhibit induce Ucp1 transcription, enhance of mitochondrial respiration, activate protein kinase A, increase lipolysis, and increase p38 MAPK phosphorylation in cells, particularly brown adipocytes and white adipocytes. They also protect primary cardiomyocytes against hypertrophy induced by adrenergic agonists. Such compounds and methods are useful in the treatment and prevention of conditions such as obesity and associated complex metabolic, endocrine, and hemodynamic changes, as well as related conditions as dyslipidemias, cardiovascular disease, and type 2 diabetes. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/917194 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/517 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158042 | GIUS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Galera Labs, LLC (Malvern, Pennsylvania); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David R. GIUS (Chicago, Illinois); Robert A. BEARDSLEY (University City, Missouri); Yueming ZHU (Chicago, Illinois); Jon HOLMLUND (Carlsbad, California); Jeffery L. KEENE (St. Louis, Missouri) |
| ABSTRACT | A method of treating a cancer in a mammalian subject, where the cancer has multi-therapy resistance, comprises administering to the mammalian subject a therapeutically effective amount of a pentaaza macrocyclic ring complex corresponding to the Formula (I) below, optionally with administration of a further anti-cancer therapy. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/072223 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/555 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158063 | DAVIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana); AIRBASE BREATHING COMPANY, LLC. (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael D. DAVIS (Bloomington, Indiana); Stacey D. GILK (Bloomington, Indiana); Benjamin GASTON (Bloomington, Indiana); Christopher M. ROBINSON (Bloomington, Indiana); Diala EZZEDDINE (Indianapolis, Indiana) |
| ABSTRACT | The present disclosure relates to a method of treating or preventing a viral infection by raising the pH of the airways of a subject. The effect can be mediated directly by administering a pharmaceutically acceptable basic solution. Additionally, the method provides co-administering an anti-viral composition to the subject. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/916684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0078 (20130101) A61K 31/245 (20130101) A61K 31/675 (20130101) A61K 33/00 (20130101) Original (OR) Class A61K 47/02 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158075 | BOT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kite Pharma Inc. (Santa Monica, California); United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, Maryland) |
| ASSIGNEE(S) | Kite Pharma Inc. (Santa Monica, California); United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, Maryland) |
| INVENTOR(S) | Adrian BOT (Santa Monica, California); Jeffrey WIEZOREK (Santa Monica, California); William GO (Santa Monica, California); Rajul JAIN (Santa Monica, California); James N. KOCHENDERFER (Bethesda, Maryland); Steven A. ROSENBERG (Bethesda, Maryland) |
| ABSTRACT | The invention provides methods of increasing the efficacy of a T cell therapy in a patient in need thereof. The invention includes a method of conditioning a patient prior to a T cell therapy, wherein the conditioning involves administering a combination of cyclophosphamide and fludarabine. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/954070 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/664 (20130101) A61K 31/675 (20130101) A61K 31/7076 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 38/2013 (20130101) A61K 38/2053 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158085 | Nagler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cathyrn R. Nagler (Chicago, Illinois); Gabriel Nunez (Ann Arbor, Michigan); Yun-Gi Kim (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are compositions and methods for the inhibition of enteric infection. In particular, compositions comprising bacteria of the class Clostridia are administered to human and/or animal subjects to prevent or decrease susceptibility to enteric infection. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/812873 |
| CURRENT CPC | Fodder A23K 10/18 (20160501) A23K 50/75 (20160501) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/40 (20160801) A23L 33/135 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0031 (20130101) A61K 9/0053 (20130101) A61K 9/0056 (20130101) A61K 31/194 (20130101) A61K 35/742 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158108 | Con Yost et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Con Yost (Salt Lake City, Utah); Joshua D. Schiffman (Salt Lake City, Utah) |
| ABSTRACT | Disclosed are methods for treating neutrophil extracellular trap (NET) mediated inflammatory tissue damage in a patient having COVID-19, comprising administering to the patient having COVID-19 an effective amount of a pharmaceutical composition comprising a NET-inhibitory peptide (NIP) and a pharmaceutically acceptable carrier to reduce a pathological effect or symptom of the NET-mediated inflammatory tissue damage Disclosed are methods for inhibiting NET formation in a patient having COVID-19 comprising administering to the patient having COVID-19 an effective amount of a pharmaceutical composition comprising a NIP and a pharmaceutically acceptable carrier to substantially inhibit NET formation. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/923180 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158112 | Brenner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Brenner (Fredrick, Maryland); Lydia Lynch (Newton Highlands, Massachusetts); Ayano Kohlgruber (Brighton, Massachusetts) |
| ABSTRACT | Methods of promoting or inhibiting weight loss by modulating activity or levels of γδ T cells. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/929209 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/20 (20130101) A61K 38/191 (20130101) Original (OR) Class A61K 38/1793 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Peptides C07K 16/244 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158114 | Chavez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Xalud Therapeutics, Inc. (Berkeley, California); The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | Xalud Therapeutics, Inc. (Berkeley, California); The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| INVENTOR(S) | Raymond A. Chavez (Alameda, California); Linda May Rothblum Watkins (Boulder, Colorado); Robert Landry (Erie, Colorado) |
| ABSTRACT | This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/159161 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2066 (20130101) Original (OR) Class A61K 48/005 (20130101) A61K 48/0075 (20130101) A61K 48/0091 (20130101) Peptides C07K 14/5428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158144 | Kubanek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jan Kubanek (Salt Lake City, Utah); Natalya Y. Rapoport (Salt Lake City, Utah) |
| ABSTRACT | Described herein are high-boiling-point-based nanoparticles that release drugs specifically at the focus of ultrasound. The specific conjunction of the high-boiling-point-based nanoparticle formulation with low-frequency ultrasound can be used to deliver therapeutics in a safe and effective manner. The effectiveness and safety of the release is validated in vitro and in non-human primates. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993693 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 9/5153 (20130101) A61K 31/05 (20130101) A61K 31/135 (20130101) A61K 31/5377 (20130101) A61K 41/0047 (20130101) Original (OR) Class A61K 49/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158146 | MURPHY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE WISTAR INSTITUTE (Philadelphia, Pennsylvania); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maureen E. MURPHY (Philadelphia, Pennsylvania); Joseph SALVINO (Philadelphia, Pennsylvania); Donna L. GEORGE (Philadelphia, Pennsylvania); Julia LEU (Philadelphia, Pennsylvania) |
| ABSTRACT | The disclosure provides in one aspect compounds, and compositions comprising such compounds, that can be used to treat, ameliorate, and/or prevent cancer, especially colorectal cancer (CRC). In certain embodiments, the compounds of the disclosure inhibit HSP70. In other embodiments, the compounds of the disclosure promote or increase immune cell recruitment to a cancer. In yet other embodiments, the compounds of the disclosure promote and/or increase immune cell infiltration in a cancer. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/914659 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/18 (20130101) A61K 47/20 (20130101) A61K 47/22 (20130101) Original (OR) Class A61K 47/24 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158149 | Pruitt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beth L. Pruitt (Santa Barbara, California); Erica A. Castillo (Santa Barbara, California); Anna Kim (Santa Barbara, California); Gabriela Villalpando Torres (Santa Barbara, California); Kerry V. Lane (Santa Barbara, California) |
| ABSTRACT | A method for performing protein patterning is provided. In particular, the method comprises generating a photoresist pattern on a wafer using photolithography; dicing the photoresist patterned wafer into wafer chips; and performing lift-off protein patterning on the photoresist patterned wafer chips. This manufacturing technique scales up the photolithography stage of the lift-off fabrication workflow to generate high quantities of shelf-stable photoresist patterned glass substrates, which can be used to incorporate a protein pattern onto the surface of a hydrogel. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/972306 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/42 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158162 | Santich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian H. Santich (New York, New York); Mahiuddin Ahmed (New York, New York); Nai-Kong V. Cheung (New York, New York) |
| ABSTRACT | The present invention relates to compositions and methods employing conjugates that include a self-assembly and disassembly (SADA) polypeptide and a binding domain. The present invention encompasses the recognition that conjugates with a SADA polypeptide have certain improved biological properties. SADA-conjugates are described, along with uses thereof (e.g., as therapeutic or diagnostic agents) and methods of manufacture. |
| FILED | Wednesday, January 11, 2023 |
| APPL NO | 18/153228 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/547 (20170801) A61K 47/641 (20170801) Original (OR) Class A61K 51/10 (20130101) A61K 51/0495 (20130101) A61K 51/1096 (20130101) Peptides C07K 14/4746 (20130101) C07K 14/7155 (20130101) C07K 16/44 (20130101) C07K 16/3084 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) C07K 2317/622 (20130101) C07K 2319/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158180 | Bradbury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sloan-Kettering Institute for Cancer Research (New York, New York); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle S. Bradbury (New York, New York); Ulrich Wiesner (Ithaca, New York); Oula Penate Medina (Kiel, Germany); Andrew Burns (Niskayuna, New York); Jason S. Lewis (New York, New York); Steven M. Larson (New York, New York) |
| ABSTRACT | The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. In order to target a specific cell type, the nanoparticle may further be conjugated to a ligand, which is capable of binding to a cellular component associated with the specific cell type, such as a tumor marker. In one embodiment, a therapeutic agent may be attached to the nanoparticle. To permit the nanoparticle to be detectable by not only optical fluorescence imaging, but also other imaging techniques, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), computerized tomography (CT), bioluminescence imaging, and magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857413 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 49/0093 (20130101) A61K 51/1244 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) G01N 33/552 (20130101) G01N 33/574 (20130101) G01N 33/582 (20130101) G01N 33/587 (20130101) G01N 33/54346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158209 | Chai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (Los Angeles, California); Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Chai (Los Angeles, California); Mengfei Yu (Los Angeles, California) |
| ABSTRACT | Disclosed herein are compositions of biodegradable scaffolds combined with mesenchymal stem cells and methods of use thereof for the regeneration of cranial sutures and treatment of craniosynostosis, which can help reverse increased intracranial pressure and skull and neurocognitive abnormalities. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 18/057125 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/222 (20130101) A61L 27/227 (20130101) A61L 27/3633 (20130101) A61L 27/3834 (20130101) Original (OR) Class A61L 2300/412 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158279 | Desai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaydev P. Desai (Atlanta, Georgia); Yash Chetan Chitalia (Atlanta, Georgia); Seokhwan Jeong (Atlanta, Georgia) |
| ABSTRACT | The current disclosure generally relates to systems and methods of guidewire control, and in particular to systems and methods for the control of multiple degrees-of-freedom bending and the bending length of a coaxially aligned robotically steerable guidewire. The current disclosure is manually actuated, and in others, is automatically/robotically actuated. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/919763 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/09041 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158305 | Weber et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Douglas Weber (Pittsburgh, Pennsylvania); Robert Gaunt (Pittsburgh, Pennsylvania); Timothy Bruns (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods and apparatuses for monitoring and regulating physiological states and functions are disclosed. Several embodiments include application of one or more microelectrode arrays to a dorsal root ganglion for measurement of sensory neuron activity, or stimulation of sensory reflex circuits. The methods and apparatuses can be used, for example, for monitoring or controlling bladder function in a patient. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902627 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) A61B 5/112 (20130101) A61B 5/202 (20130101) A61B 5/205 (20130101) A61B 5/1107 (20130101) A61B 5/4064 (20130101) A61B 5/4255 (20130101) A61B 5/4393 (20130101) A61B 5/4519 (20130101) A61B 5/4824 (20130101) A61B 5/4836 (20130101) A61B 5/7246 (20130101) A61B 2560/0223 (20130101) A61B 2562/04 (20130101) A61B 2562/028 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/0551 (20130101) A61N 1/36003 (20130101) A61N 1/36007 (20130101) A61N 1/36062 (20170801) A61N 1/36071 (20130101) A61N 1/36082 (20130101) A61N 1/36107 (20130101) A61N 1/36139 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158321 | SHELTRAW et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DANIEL J. SHELTRAW (ALBANY, California); BENJAMIN A. INGLIS (Lafayette, California); RICHARD IRWIN IVRY (El Cerrito, California); LUDOVICA LABRUNA (Kensington, California) |
| ABSTRACT | A magnetic stimulation system has at least two magnetic coils, each coil to generate an induced electric field of a magnitude having a desired effect on a brain, at least two frequency controllers, wherein each coil is electrically connected to a corresponding frequency controller, the frequency controllers to adjust a frequency of power supplied to the corresponding coils according to a desired interference pattern, and at least one power source to provide power to the frequency controllers corresponding to each coil. A method of operating a magnetic stimulation system includes generating two or more signals to apply to two or more coils, each signal corresponding to one of the at least two coils, wherein at least two coils receive different signals and the different signals differ at least in frequency according to a desired temporal interference pattern. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/921563 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/40 (20130101) A61N 2/02 (20130101) A61N 2/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158322 | Gao |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Wei Gao (Santa Clarita, California) |
| ABSTRACT | A patient transfer assembly can transfer patients (e.g., young, sleeping patients or patients unable to move freely/easily) onto a destination surface (e.g., an imaging table of an imaging device) gently (e.g., with a reduced chance of waking). The assembly can include rollers permitting the assembly to be rolled into a position above or adjacent the destination surface. A support surface upon which the patient rests can be moved to a deployed position (e.g., lowered and/or slid out) and/or the destination surface can be raised until the support surface rests upon the destination surface. The support surface can then be detached, allowing the patient and the support surface to remain on the destination surface without needing to remove the patient from the support surface. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 18/011589 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) Original (OR) Class A61N 2/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158455 | MONTGOMERY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cellphire, Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | Cellphire, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Joshua Donald MONTGOMERY (Silver Spring, Maryland); Braden Carl ISHLER (Montgomery Village, Maryland); Stephen Edward AMOS (Buckeystown, Maryland); Keith Andrew MOSKOWITZ (Westfield, Indiana); Amber Nicole LEE (Montgomery Village, Maryland); Rafael JORDA (Merignac, France); Glen Michael FITZPATRICK (North Potomac, Maryland); Michael Alexander MATHEWS (Arlington, Virginia) |
| ABSTRACT | Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099796 |
| CURRENT CPC | Separation B01D 61/14 (20130101) Original (OR) Class B01D 2311/12 (20130101) B01D 2315/10 (20130101) B01D 2315/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158495 | KANSO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eva KANSO (Los Angeles, California); Janna NAWROTH (Munich, Germany); Feng LING (Los Angeles, California); Kakani Katija YOUNG (Carmel Valley, California); Margaret Jean McFALL-NGAI (Kailua, Hawaii); Michael SHELLEY (Los Angeles, California) |
| ABSTRACT | A method for designing a microfluidic device includes steps of: a) receiving an input design of a bare microfluidic channel to which one or more cilia layers are to be added, the bare microfluidic channel having a predetermined cross section, the bare microfluidic channel defining an inner surface and an outer surface, a first direction being a fluid flow direction along a length of the bare microfluidic channel and a second direction perpendicular to the first direction; b) receiving operation parameters for a ciliated microfluidic channel formed from the bare microfluidic channel, the operation parameters including fluid viscosity and an opposing pressure gradient in an adverse direction to the fluid flow direction; and c) determining cilia design parameters for the one or more cilia layers to be attached to and distributed over the inner surface, the cilia design parameters being determined from the incompressible Brinkman equation. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947837 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 3/502707 (20130101) B01L 2300/16 (20130101) B01L 2300/0645 (20130101) B01L 2400/043 (20130101) B01L 2400/0493 (20130101) Electric Digital Data Processing G06F 30/28 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158498 | Frydman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Galit H. Frydman (Boston, Massachusetts); Mehmet Toner (Charlestown, Massachusetts); Ronald G. Tompkins (Boston, Massachusetts); Pavan Bendapudi (Boston, Massachusetts) |
| ABSTRACT | Methods and devices for evaluating coagulation are described, including methods and devices for detecting an anticoagulant agent or a coagulation abnormality. In various embodiments, the methods and devices of the invention measure coagulation of a sample in response to a gradient of one or more coagulation factors. These responses can be evaluated to accurately profile coagulation impairments of the sample, including the presence of anticoagulant medication. In various embodiments, the invention provides point-of-care or bedside testing with a convenient, microfluidic device that can be used by minimally trained personnel. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/159276 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/4846 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) Original (OR) Class B01L 2300/165 (20130101) B01L 2400/088 (20130101) B01L 2400/0406 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) G01N 33/4905 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158499 | Frydman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Galit H. Frydman (Boston, Massachusetts); Mehmet Toner (Charlestown, Massachusetts); Ronald G. Tompkins (Boston, Massachusetts); Pavan Bendapudi (Boston, Massachusetts) |
| ABSTRACT | Methods and devices for evaluating coagulation are described, including methods and devices for detecting an anticoagulant agent or a coagulation abnormality. In various embodiments, the methods and devices of the invention measure coagulation of a sample in response to a gradient of one or more coagulation factors. These responses can be evaluated to accurately profile coagulation impairments of the sample, including the presence of anticoagulant medication. In various embodiments, the invention provides point-of-care or bedside testing with a convenient, microfluidic device that can be used by minimally trained personnel. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/159283 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/4846 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) Original (OR) Class B01L 2300/165 (20130101) B01L 2400/088 (20130101) B01L 2400/0406 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) G01N 33/4905 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159475 | Chopra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Gaurav Chopra (West Lafayette, Indiana); Prageeth Wijewardhane (West Lafayette, Indiana); Krupal P. Jethava (West Lafayette, Indiana); Jonathan Fine (Jersey City, New Jersey) |
| ABSTRACT | The present invention generally relates to new compounds for therapeutic uses. In particular, the disclosed series compounds with immunomodulatory activities are useful for treatment of dysfunctions of the immune system and various cancers. Pharmaceutical composition matters and methods for treating a patient with an immune disease and/or a cancer by administering therapeutically effective amounts of such compound alone or together with other therapeutics are within the scope of this disclosure. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/908530 |
| CURRENT CPC | Heterocyclic Compounds C07D 211/32 (20130101) C07D 277/24 (20130101) Original (OR) Class C07D 319/20 (20130101) C07D 413/06 (20130101) C07D 413/14 (20130101) C07D 419/04 (20130101) C07D 419/14 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159500 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chapman University (Orange, California); The Board of Regents of The University of Texas System (Austin, Texas); Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miao Zhang (Orange, California); Keykavous Parang (Orange, California); Naglaa Ibrahim (Orange, California); Young Woo Nam (Orange, California); Ilya Bezprozvanny (Austin, Texas); Meng Cui (Boston, Massachusetts) |
| ABSTRACT | A compound according to Formula (I) or a pharmaceutically acceptable salt thereof: is provided. X1 is N or C-Y; Y is H, halogen, NH2, OH, SH, alkyl, aryl, alkoxy, or aryloxy; A is O, NH, S, Se, or CH2, B is X2 is N or CH; and Z is NH, CH2, S, O, or Se. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956553 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/04 (20130101) Original (OR) Class C07D 403/14 (20130101) C07D 413/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159514 | Werner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Inhibikase Therapeutics, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milton H. Werner (Marietta, Georgia); Terence A. Kelly (Ridgefield, Connecticut) |
| ABSTRACT | The present invention provides compounds for the prevention or treatment of cancer or a bacterial or viral infection. Additionally, the present invention provides compositions and methods for using these compounds and compositions in the prevention or treatment of cancer or a bacterial or viral infection in a subject. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/14 (20130101) C07D 413/14 (20130101) C07D 417/14 (20130101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159516 | Ghosh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Hiroaki Mitsuya (Kumamoto, Japan); Monika Yadav (West Lafayette, Indiana); Andrew Mesecar (West Lafayette, Indiana) |
| ABSTRACT | Bis-amide inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/996898 |
| CURRENT CPC | Heterocyclic Compounds C07D 417/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159542 | Nabors et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama); SOUTHERN RESEARCH INSTITUTE (Birmingham, Alabama); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama); SOUTHERN RESEARCH INSTITUTE (Birmingham, Alabama); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | Louis B. Nabors (Birmingham, Alabama); Natalia Filippova (Birmingham, Alabama); Xiuhua Yang (Birmingham, Alabama); Subramaniam Ananthan (Birmingham, Alabama); Vibha Pathak (Birmingham, Alabama); Peter King (Birmingham, Alabama) |
| ABSTRACT | This disclosure provides compounds that inhibit RNA-binding proteins, such as Human antigen R protein (HuR). The compounds described herein have a high affinity for HuR multimers and inhibit the pathological processes that promote cancer and inflammation. The compounds are highly water-soluble and have good biodistribution for both systemic and central nervous system disease processes. The compounds provide a unique therapeutic option for disease processes related to neoplastic progression or acute or chronic inflammation. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/996886 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 29/00 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159552 | BOGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRISTOL-MYERS SQUIBB COMPANY (Princeton, New Jersey); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dale L. BOGER (La Jolla, California); Naidu S. CHOWDARI (Dublin, California); Sanjeev GANGWAR (Foster City, California) |
| ABSTRACT | Compounds according to formula (I), where R is as defined herein, have anti-cancer properties. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/916947 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/35 (20130101) Heterocyclic Compounds C07D 493/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159573 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shaomeng Wang (Superior Township, Michigan); Haibin Zhou (Ann Arbor, Michigan); Renqi Xu (Ann Arbor, Michigan); Longchuan Bai (Ann Arbor, Michigan); Donna McEachern (Ann Arbor, Michigan); Jeanne Stuckey (Fenton, Michigan); Chao-Yie Yang (Ann Arbor, Michigan) |
| ABSTRACT | The present disclosure provides compounds represented by Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1b, R3a, R4, A, E1, E2, M, and Q are as set forth in the specification. Compounds of Formula (I) are STAT protein degraders and thus are useful for the treatment of cancer and other diseases. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/911728 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6561 (20130101) Original (OR) Class C07F 9/655354 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159596 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Holland Cheng (Oakland, California); Chun Chieh Chen (Oakland, California); Mohammad Ali Baikoghli (Oakland, California); Marie Stark (Oakland, California) |
| ABSTRACT | A Hepatitis E virus (HEV)-based virus like nanoparticle (HEVNP) made with a modified capsid protein containing at least a portion of open reading frame 2 (ORF2) protein conjugated with gold nanocluster is provided. Also provided are methods of targeted delivery of a nucleic acid using the HEVNP. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/935682 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/62 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159597 | POROTTO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matteo POROTTO (New York, New York); Anne MOSCONA (New York, New York); Samuel GELLMAN (Madison, Wisconsin); Victor OUTLAW (Madison, Wisconsin); Zhen YU (Madison, Wisconsin) |
| ABSTRACT | Described herein is a composition and method of treating COVID-19 with lipid-peptide fusion antiviral therapy. Also described is a composition and method of treating Ebola with lipid-peptide fusion antiviral therapy. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/996917 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/60 (20170801) A61K 47/543 (20170801) A61K 47/545 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159602 | Somasundaram et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Wistar Institute (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajasekharan Somasundaram (Philadelphia, Pennsylvania); Kar Muthumani (Philadelphia, Pennsylvania); David Weiner (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to recombinant optimized polynucleotide encoding a cytokine or cytokine receptor and to methods of making a recombinant optimized polynucleotide encoding a cytokine or cytokine receptor. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937005 |
| CURRENT CPC | Peptides C07K 14/53 (20130101) Original (OR) Class C07K 14/505 (20130101) C07K 14/575 (20130101) C07K 14/715 (20130101) C07K 14/5403 (20130101) C07K 14/5418 (20130101) C07K 14/5443 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159614 | Levin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Noam Levin (Rockville, Maryland); Rami Yoseph (Gaithersburg, Maryland); Biman C. Paria (Germantown, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed are isolated or purified T cell receptors (TCRs), wherein the TCRs have antigenic specificity for a mutated RAS amino acid sequence presented by a human leukocyte antigen (HLA) Class II molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802464 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001111 (20180801) Peptides C07K 14/7051 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5748 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159616 | Farzan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INCORPORATED (Gainsville, Florida); EMMUNE, INC. (Juno Beach, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Farzan (Juno Beach, Florida); Matthew Gardner (Jupiter, Florida); Ina Fetzer (Palm Beach Gardens, Florida); Michael Alpert (Jupiter, Florida); Charles Bailey (Jupiter, Florida) |
| ABSTRACT | The invention relates to proteins that contain the CD4 domain 1 and the CD4 domain 2 (CD4 D1D2), wherein the CD4 D1D2 contains one or more mutations compared to wild-type human CD4 D1D2, and to methods of using the proteins for treating a human immunodeficiency virus (HIV) infection in a subject. |
| FILED | Thursday, March 21, 2019 |
| APPL NO | 16/982134 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/70514 (20130101) Original (OR) Class C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159622 | Raines et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald T. Raines (Cambridge, Massachusetts); Matthew D. Shoulders (Cambridge, Massachusetts); Jonathan A. Hodges (Durham, North Carolina) |
| ABSTRACT | Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly)n, where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. Methods are also disclosed for making the novel collagen mimics. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855372 |
| CURRENT CPC | Peptides C07K 5/0821 (20130101) C07K 14/001 (20130101) C07K 14/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159626 | OGEMBO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Javier Gordon OGEMBO (San Dimas, California); Lorraine Zvichapera MUTSVUNGUMA (Duarte, California); Alison Evelynn ONDRUS (Pasadena, California) |
| ABSTRACT | Disclosed herein are antibodies or immunogenic fragments thereof that specifically bind to Epstein-Barr virus (EBV) glycoprotein 350 (gp350) or 220 or one or more epitopes of EBV gp350 and neutralize EBV infection. Also disclosed are immunogenic peptides comprising one or more gp350 epitopes, EBV antibody-small molecule conjugates and pharmaceutical compositions comprising the antibody or an immunogenic fragment thereof, one or more epitopes of EBV gp350, one or more immunogenic peptides, or the EBV antibody-small molecule conjugate. The antibodies, epitopes, immunogenic peptides, conjugates, and pharmaceutical compositions can be used to treat or prevent EBV infections and EBV-associated conditions and diseases. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816188 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/763 (20130101) A61K 38/162 (20130101) A61K 39/42 (20130101) A61K 39/245 (20130101) A61K 47/65 (20170801) A61K 47/6811 (20170801) A61K 47/6839 (20170801) Peptides C07K 16/085 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/16222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159629 | Medof et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Edward Medof (Pepper Pike, Ohio); Devin Cao (Cleveland, Ohio); Daniel Counihan (Cleveland, Ohio); Shiva Sridar (Cleveland, Ohio) |
| ABSTRACT | A method of modulating growth factor responses of cells expressing C3a receptor (C3aR) and C5a receptor (C5aR) and at least one growth factor receptor includes administering to the cells a thrombin inhibitor. |
| FILED | Thursday, January 12, 2023 |
| APPL NO | 18/096349 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/06 (20130101) A61K 38/08 (20130101) A61K 38/57 (20130101) A61K 38/58 (20130101) A61K 45/06 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/28 (20130101) C07K 16/248 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159649 | Croft et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | La Jolla Institute for Immunology (Jolla, California) |
| ASSIGNEE(S) | La Jolla Institute for Immunology (La Jolla, California) |
| INVENTOR(S) | Michael Croft (La Jolla, California); Rana Herro (La Jolla, California) |
| ABSTRACT | Provided herein are methods for one or more of reducing or inhibiting a fibrotic disease in a subject in need thereof; treating a skin disease or inflammation in a subject in need thereof; treating an autoimmune disorder in a subject in need thereof; treating a respiratory disease in a subject in need thereof, which comprises modulating the activity of LIGHT (p30 polypeptide) and the activity of TNF-like Ligand 1A (TL1A) in the subject. Also disclosed herein include pharmaceutical compositions, combinations, and kits for use with one or more of the methods disclosed herein. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/916548 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 37/00 (20180101) Peptides C07K 16/2875 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159653 | NIKOLOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York); The U.S.A, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maine) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DIMITAR NIKOLOV (New York, New York); NAYANENDU SAHA (New York, New York); ZHONGYU ZHU (Frederick, Maryland); DIMITER STANCHEV DIMITROV (Frederick, Maryland); DOROTHEA ROBEV (New York, New York); THOMAS EDGEWORTH WHITE (Norwalk, Connecticut) |
| ABSTRACT | The present invention provides various ADAM17 binding molecules (including antibodies and fragments thereof), compositions comprising such ADAM17 binding molecules, and methods of using such ADAM17 binding molecules and compositions, for example in inhibiting binding of ADAM17 to ADAM17 substrates (such as ErbB ligands), in inhibiting the proliferation of cancer cells, and in treating cancer. |
| FILED | Saturday, March 07, 2020 |
| APPL NO | 17/437065 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159758 | HELGASON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VitroLabs Inc (Milpitas, California); King's College London (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ingvar HELGASON (South San Francisco, California); Dusko ILIC (London, United Kingdom) |
| ABSTRACT | Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/092816 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 89/06 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0625 (20130101) C12N 5/0629 (20130101) C12N 5/0698 (20130101) C12N 11/02 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2502/13 (20130101) C12N 2502/091 (20130101) C12N 2502/094 (20130101) C12N 2506/45 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) Chemical Treatment of Hides, Skins or Leather, e.g Tanning, Impregnating, Finishing; Apparatus Therefor; Compositions for Tanning C14C 3/02 (20130101) C14C 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159887 | Parent et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Audrey Parent (San Francisco, California); Matthias Hebrok (Belmont, California); Mark Stuart Anderson (Larkspur, California) |
| ABSTRACT | The present description provides improved methods for generating thymic epithelial progenitor (TEP) cells from pluripotent stem (PS) cells in vitro. Also provided are isolated invitro cell populations, compositions, and systems comprising TEP cells produced in vitro. Compositions and systems of cell populations of thymic epithelial cells and subpopulations thereof, as well as cells formed during different stages of differentiation of PS cells into thymic epithelial cells and subpopulations thereof are provided. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/921739 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0617 (20130101) Original (OR) Class C12N 2500/25 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/30 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/415 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159890 | GOLDMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. GOLDMAN (Webster, New York); John Mariani (Rochester, New York) |
| ABSTRACT | A genetically modified glial cells, and use of such cells for rejuvenating glial cell population or treating glial cell-related disorders are disclosed. A method of treating a disorder of the brain and/or brain stem in a subject by introducing a population of genetically modified glial progenitor cells into the brain and/or brain stem of the subject, wherein the genetically modified glial progenitor cells have increased expression of one or more genes compared to the same type of glial progenitor cells that have not been genetically modified, wherein said increased expression of the one or more genes in the genetically modified glial progenitor cells confer competitive advantage over native or already resident glial progenitor cells in the subject. |
| FILED | Sunday, October 16, 2022 |
| APPL NO | 18/046928 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 5/0623 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159894 | Loh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle M. Loh (Piscataway, New Jersey); Lay Teng Ang (Stanford, California); Alana T. Nguyen (Stanford, California); Jonas Fowler (Stanford, California); Irving L. Weissman (Stanford, California) |
| ABSTRACT | Methods are provided for the efficient differentiation of hPSCs into HSC-like cells and endothelial cells in defined, monolayer conditions solely using extracellular signals to guide differentiation. The instant disclosure also provides methods of screening for cellular responses of the generated hematopoietic stem cells, endothelial cells and derivatives thereof. Treatment methods making use of the generated hematopoietic stem cells and endothelial cells are also provided. The instant disclosure also provides systems, compositions, and kits for practicing the methods of the disclosure. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/995274 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 5/0691 (20130101) C12N 2500/38 (20130101) C12N 2501/155 (20130101) C12N 2501/165 (20130101) C12N 2501/235 (20130101) C12N 2501/415 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159895 | Radtke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Stefan Radtke (Seattle, Washington); Hans-Peter Kiem (Seattle, Washington); Jennifer E. Adair (Seattle, Washington) |
| ABSTRACT | Strategies to assess and/or produce cell populations with predictive engraftment potential are described. The cell populations can be used for a variety of therapeutic and research purposes. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 18/057098 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 2501/26 (20130101) C12N 2501/125 (20130101) C12N 2501/145 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) G01N 2333/70589 (20130101) G01N 2333/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159896 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Arun Sharma (Los Angeles, California); Samuel Sances (Santa Monica, California); Clive Svendsen (Pacific Palisades, California) |
| ABSTRACT | Described herein is a human, cardiovascular platform for assessing cardiotoxicity of novel/existing chemotherapeutic agents that takes advantage of microfluidic organ chip systems to examine interaction between hiPSC-derived cardiovascular cells in an integrated system. Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) and human induced pluripotent stem cell derived endothelial cells (hiPSC-ECs) can serve as an in-vitro platform for assessing disease pathology, including infectious disease, evaluate drug efficacy, toxicity, cardiotoxicity and cardioprotection. This includes evaluating VEGFR2/PDGFR-inhibiting tyrosine kinase inhibitors and drug efficacy in a viral infection model, including coronaviruses. They are scalable, functionally-active cell types that mimic the cells comprising the myocardium and systemic vasculature. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/921217 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) C12M 29/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) C12N 5/0657 (20130101) Original (OR) Class C12N 5/0697 (20130101) C12N 2506/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159897 | KLEMKE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard KLEMKE (La Jolla, California); Huawei WANG (San Diego, California) |
| ABSTRACT | Provided herein are cytoplasts, compositions comprising cytoplasts, methods of using cytoplasts, and methods of treating a subject, such as providing benefits to a healthy or unhealthy subject, or treating or diagnosing a disease or condition in a subject. In some embodiments, methods of treating a subject include: administering to the subject a therapeutically effective amount of a composition comprising a cytoplast. Also, provided herein are compositions (e.g., pharmaceutical compositions) that include a cytoplast. Also, provided herein are kits comprising instructions for using the compositions or methods. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992372 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/12 (20130101) A61K 35/28 (20130101) A61K 38/2066 (20130101) A61K 39/215 (20130101) A61K 39/001102 (20180801) A61K 2039/515 (20130101) A61K 2039/545 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0662 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2501/999 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159906 | Vlahos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Elias Vlahos (Los Altos, California); Xiaojing Gao (Redwood City, California); Jeewoo Kang (Redwood City, None) |
| ABSTRACT | To program intercellular communication for biomedicine, it is crucial to regulate the secretion and surface display of signaling proteins. If such regulations are at the protein level, there are additional advantages, including compact delivery and direct interactions with endogenous signalling pathways. A modular, generalizable design is provided called Retained Endoplasmic Cleavable Secretion (RELEASE), with engineered proteins retained in the endoplasmic reticulum and displayed/secreted in response to specific proteases. The design allows functional regulation of multiple synthetic and natural proteins by synthetic protease circuits to realize diverse signal processing capabilities, including logic operation and threshold tuning. By linking RELEASE to additional novel sensing and processing circuits, one would be able to achieve elevated protein secretion in response to “undruggable” oncogene KRAS mutants. RELEASE enables the local, programmable delivery of intercellular cues for a broad variety of fields such as neurobiology, cancer immunotherapy and cell transplantation. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 17/985624 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/723 (20130101) C07K 14/70517 (20130101) C07K 2319/04 (20130101) C07K 2319/036 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/506 (20130101) Original (OR) Class Enzymes C12Y 304/22044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159920 | Bradley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Robert K. Bradley (Seattle, Washington); Omar Abdel-Wahab (New York, New York); Daichi Inoue (New York, New York) |
| ABSTRACT | The current disclosure relates to methods and compositions for increasing functional expression of BRD9 in a cell. The methods and compositions can be incorporated into methods for treating cancer through the administration of BRD9 activating therapies. Accordingly, aspects of the disclosure relate to compositions and methods for treating cancer, a pre-malignant disease, or a dysplastic disease in a subject. The method can comprise administering a BRD9 activating therapy to the subject. |
| FILED | Thursday, June 25, 2020 |
| APPL NO | 17/621429 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159927 | Gersbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles A. Gersbach (Chapel Hill, North Carolina); Nahid Iglesias (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are fusion proteins for the targeted activation of genes as well as compositions and methods and DMA Targeting Systems comprising the same. The fusion protein may include at least one first polypeptide domain and at least one second polypeptide domain. The first polypeptide domain includes a DMA binding protein, such as a zinc finger protein, a TALE, or a Cas protein, that targets the fusion protein for binding to a specific DNA sequence. The second polypeptide domain includes a modulator of chromatin structure. The fusion protein may further include a third polypeptide domain, the third polypeptide domain including a transcriptional activator domain. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/922751 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159931 | LIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Hening LIN (Ithaca, New York); Mingming ZHANG (Ithaca, New York); Tao YU (Ithaca, New York) |
| ABSTRACT | This disclosure is directed to methods for treating an inflammatory disorder, comprising administering to a patient suffering from the disorder an effective amount of an inhibitor of an enzyme that regulates the S-palmitoylation of a pro-inflammatory transcription factor. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/919650 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159943 | JACOBSEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Steve E. JACOBSEN (Agoura Hills, California); Zheng LI (Los Angeles, California); Jennifer DOUDNA (Berkeley, California); Patrick PAUSH (Berkeley, California); Basem AL-SHAYEB (Berkeley, California) |
| ABSTRACT | The present disclosure relates to CRISPR-Cas systems that utilize Cas 12J for editing nucleic acids in plants. Methods and compositions for using these systems for editing nucleic acids in plants are provided herein. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/919503 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/8213 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159952 | Daigle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ALLEN INSTITUTE (Seattle, Washington) |
| ASSIGNEE(S) | ALLEN INSTITUTE (Seattle, Washington) |
| INVENTOR(S) | Tanya Daigle (Lake Forest Park, Washington); Lucas T. Graybuck (Seattle, Washington); Brian Edward Kalmbach (Poulsbo, Washington); Edward Sebastian Lein (Mercer Island, Washington); Boaz P. Levi (Seattle, Washington); John K. Mich (Seattle, Washington); Adriana Estela Sedeño Cortés (Seattle, Washington); Bosiljka Tasic (Seattle, Washington); Jonathan Ting (Lake Forest Park, Washington); Hongkui Zeng (Seattle, Washington) |
| ABSTRACT | Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. Particularly, the artificial expression constructs can be used to selectively express synthetic genes and/or modify gene expression in neocortical glutamatergic layer 5 neurons, such as glutamatergic layer 5 extratelencephalic-projecting (L5 ET) neurons. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/996910 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159953 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Lina Li (Potomac, Maryland); Robert Kotin (Bethesda, Maryland) |
| ABSTRACT | Closed-ended, linear, duplex (CELiD) DNA molecules, recombinant AAV (rAAV), particles comprising CELiD DNA, methods of making such molecules and particles, and therapeutic applications of such particles. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/151803 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2310/532 (20130101) C12N 2750/14123 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159957 | MARSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander MARSON (Oakland, California); Brian SHY (Oakland, California); Jonathan ESENSTEN (Oakland, California) |
| ABSTRACT | The disclosure provides compositions and methods for modifying a target nucleic acid that use a donor construct including at least one donor template comprising a single-stranded homology directed repair template (ssHDRT) and one or more DNA-binding protein target sequences, in which at least one DNA-binding protein target sequence forms a double-stranded duplex with a complementary polynucleotide sequence. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/911391 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159973 | DELISA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew P. DELISA (Ithaca, New York); Aravind NATARAJAN (Menlo Park, California) |
| ABSTRACT | The present application relates to recombinant prokaryotic host cells expressing one or more 4-epimerases, one or more glycosyl-1-phosphate transferases, one or more O-oligosaccharyltransferases, and, optionally, one or more ß1,3-galactosyltransferase enzymes capable of transferring galactose to undecaprenyl pyrophosphate-linked N-Acetylgalactosamine. Also disclosed are methods for producing an O-glycosylated protein. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/920532 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) C12N 9/1048 (20130101) C12N 9/1205 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class Enzymes C12Y 204/01122 (20130101) C12Y 207/0106 (20130101) C12Y 501/03002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159986 | Chiu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Mammoth Biosciences, Inc. (Brisbane, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles Chiu (Oakland, California); Janice Sha Chen (Brisbane, California); Xin Miao (Brisbane, California) |
| ABSTRACT | The disclosure provides methods for characterizing a target DNA present in a sample. The methods involve contacting the sample with one or more universal primers to amplify target DNA; contacting the amplified target DNA with a type V CRISPR/Cas effector protein and one or more guide RNAs, where the contacting generates a cleavage product comprising a 5′ overhang; and ligating a double-stranded nucleic acid adapter to the cleavage product, to generate a ligation product. The ligation product includes the target DNA, which can be sequenced. The sample can be subjected to one or more amplification steps prior to the contacting step, with primers that provide for amplification of nucleic acids of, e.g., specific pathogens, categories of pathogens, two or more different pathogens, or two or more different categories of pathogens. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/920571 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6893 (20130101) C12Q 1/6895 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159992 | PATNO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mammoth Biosciences, Inc. (Brisbane, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy James PATNO (Barrington, Illinois); Jesus CHING (Saratoga, California); James Paul BROUGHTON (South San Francisco, California); Xin MIAO (Mountain View, California); Janice Sha CHEN (San Francisco, California); Clare Louise FASCHING (Redwood City, California); Alexander HIRSCHI (Redwood City, California); Raymond Weibang MEI (Castro Valley, California); Wesley Wendell ADDISON, II (Oakland, California); Nazmiye Emel ALPAY (Mountain View, California); Farzaneh TONDNEVIS (San Jose, California); Sara ANSALONI (Mountain View, California); Deepika VERMA (Belmont, California) |
| ABSTRACT | Disclosed herein are systems and methods for providing a high-throughput DETECTR assay in a single chamber. The single chamber may be one well of a microplate, and multiple assays may be conducted in a staggered fashion in separate chambers. The methods described herein implement a process including lysing a sample, isolating nucleic acid molecules, eluting the nucleic acid molecules, amplifying the nucleic acid molecules, and detecting a presence of a target nucleic acid. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155675 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/6806 (20130101) C12Q 1/6823 (20130101) Original (OR) Class C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159998 | PHILLIPS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BIOFIRE DEFENSE, LLC (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cynthia L. PHILLIPS (Salt Lake City, Utah); Kenneth K.C. BRAMWELL (Salt Lake City, Utah); Kirk M. RIRIE (Salt Lake City, Utah); Mark Aaron PORITZ (Salt Lake City, Utah) |
| ABSTRACT | Systems, methods, and apparatus are provided for external control testing of an assay system. |
| FILED | Tuesday, January 29, 2019 |
| APPL NO | 16/965853 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 7/52 (20130101) B01L 2200/16 (20130101) B01L 2300/18 (20130101) B01L 2300/0654 (20130101) B01L 2300/0861 (20130101) B01L 2400/0481 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160003 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Shoujun Xu (Houston, Texas); Qiongzheng Hu (Houston, Texas); Yuhong Wang (Housjton, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices. |
| FILED | Monday, June 11, 2018 |
| APPL NO | 16/620571 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 7/52 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160014 | Khatri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purvesh Khatri (Menlo Park, California); Timothy E. Sweeney (Truckee, California) |
| ABSTRACT | This disclosure provides a gene expression-based method for determining whether a subject having sepsis has an Inflammopathic phenotype, an Adaptive phenotype or a Coagulopathic phenotype. A kit for performing the method is also provided. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099910 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160025 | KIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GoDx, Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chang Hee KIM (Waunakee, Wisconsin); Jacob Jerome TOKAR (Madison, Wisconsin); Fernando R. MOREIRA (Madison, Wisconsin); Xiao JIANG (Madison, Wisconsin) |
| ABSTRACT | The present invention provides compositions comprising primers for loop-mediated isothermal amplification of a target nucleotide sequence of SARS-CoV-2, as well as point-of-care diagnostic devices and kits comprising said compositions. Methods of using the compositions, devices, and kits to detect SARS-CoV-2 in a sample are also provided. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049552 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160806 | ZHAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weian ZHAO (Irvine, California); Enrico GRATTON (Irvine, California); Per N. HEDDE (Irvine, California) |
| ABSTRACT | Provided are processes, methods, kits, devices and software for testing and detecting proteins such as antigens, cytokines or antibodies, particles or cells in specimens of or samples from human or animals; and in alternative embodiments the protein are induced by or derived from viruses, bacteria, an immune system, a cancer cell or any cell which can cause a disease, infection or condition such as a COVID-19 infection. Provided are portable imaging systems comprising flat static surfaces or slides, wherein the flat static surfaces or slides can be fabricated as printed microarrays, or biochips that can support protein or bioparticle precipitates. Provided are portable imaging systems comprising imaging systems with light sheet illumination to image two dimensional (2D) planes in liquids to detect proteins, bioparticles, cells, and organisms. Portable imaging systems provided herein can be used for point-of-care diagnosis, immunity analysis, epidemiological surveillance, and therapeutics and vaccine development. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/921014 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) G01N 15/1434 (20130101) Original (OR) Class G01N 33/54306 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0008 (20130101) G02B 21/16 (20130101) G02B 21/086 (20130101) G02B 21/361 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/10722 (20130101) Pictorial Communication, e.g Television H04N 25/71 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160898 | CONBOY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOHN CONBOY (Salt Lake City, Utah); KRYSTAL SLY (San Diego, California) |
| ABSTRACT | Disclosed are methods of detecting an analyte of interest comprising introducing a sample comprising an analyte of interest to an antibody or antibody fragment; incubating the sample and antibody or antibody fragment under conditions sufficient to allow binding of the analyte of interest to the antibody or antibody fragment; and detecting the binding of the analyte of interest to the antibody or antibody fragment using a label-free second harmonic detection system. Also disclosed are methods of screening and diagnosing using antibodies or antibody fragments and a label-free second harmonic detection system. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/150039 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/05 (20130101) G01N 21/636 (20130101) G01N 33/543 (20130101) G01N 33/57484 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160908 | Greene et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark I. Greene (Penn Valley, Pennsylvania); Douglas B. Cines (Wynnewood, Pennsylvania); Zheng Cai (Wynnewood, Pennsylvania); Zhiqiang Zhu (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides a humanized antibody or antibody fragment comprising (a) a humanized light chain comprising 1) Complementarity Determining Region (CDR)-L1, the sequence of which is identical to the sequence of SEQ ID NO: 3; 2) CDR-L2, the sequence of which is identical to the sequence of SEQ ID NO: 4; and 3) CDR-L3, the sequence of which is identical to the sequence of SEQ ID NO: 5, and (b) a humanized heavy chain comprising 1) CDR-H1, the sequence of which is identical to the sequence of SEQ ID NO: 6; 2) CDR-H2, the sequence of which is identical to the sequence of SEQ ID NO: 7; and 3) CDR-H3, the sequence of which is identical to the sequence of SEQ ID NO: 8, as well as methods for treating, diagnosing, and monitoring the progression of HIT. The present invention also provides methods for assessing the antigenicity and ability to cause HIT of anionic anticoagulants. The present invention also provides a mutant protein which has the same amino acid sequence of a wild type PF4 monomer except that (i) at least one amino acid of the wild type PF4 monomer has been deleted, (ii) at least one amino acid of the wild type PF4 monomer has been replaced by another amino acid, or (iii) a combination of such changes has been made. The present invention also provides methods of treating or reducing the likelihood of HIT, treating angiogenesis, treating abnormal cell growth, or affecting coagulation pathologies that lead to thrombus formation, by administering such mutant proteins to a patient. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/929524 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/195 (20130101) A61K 39/3955 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/522 (20130101) C07K 16/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) G01N 33/6863 (20130101) Original (OR) Class G01N 2333/522 (20130101) G01N 2400/40 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160983 | ALIPOUR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Akbar ALIPOUR (New York, New York); Priti BALCHANDANI (New York, New York); Alan C. SEIFERT (New York, New York) |
| ABSTRACT | A radiofrequency (RF) resonator array device for use in magnetic resonance imaging (MRT), The RF resonator array device includes a substrate. An army of coupled split ring resonators are located on the substrate. Each of the coupled split ring resonators includes a first split ring resonator positioned on a first side of the substrate and a second split ring resonator positioned on a second side of the substrate located opposite the first side. The second split ring resonator is inductively coupled to the first split ring resonator. Methods of making and using the RF resonator device are also disclosed. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/922912 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/343 (20130101) Original (OR) Class G01R 33/3642 (20130101) G01R 33/34076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160987 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Yi Wang (New York, New York); Zhe Liu (New York, New York); Youngwook Kee (New York, New York); Alexey Dimov (New York, New York); Yan Wen (New York, New York); Jingwei Zhang (Woodside, New York); Pascal Spincemaille (New York, New York) |
| ABSTRACT | Exemplary quantitative susceptibility mapping methods, systems and computer-accessible medium can be provided to generate images of tissue magnetism property from complex magnetic resonance imaging data using the Bayesian inference approach, which minimizes a cost function consisting of a data fidelity term and two regularization terms. The data fidelity term is constructed directly from the complex magnetic resonance imaging data. The first prior is constructed from matching structures or information content in known morphology. The second prior is constructed from a region having an approximately homogenous and known susceptibility value and a characteristic feature on anatomic images. The quantitative susceptibility map can be determined by minimizing the cost function. Thus, according to the exemplary embodiment, system, method and computer-accessible medium can be provided for determining magnetic susceptibility information associated with at least one structure. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/151860 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/0263 (20130101) A61B 5/7203 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/24 (20130101) G01R 33/50 (20130101) G01R 33/5608 (20130101) Original (OR) Class G01R 33/56527 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161810 | Daugharthy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan R. Daugharthy (Cambridge, Massachusetts); Vivek Dasari (Cambridge, Massachusetts); George M. Church (Brookline, Massachusetts) |
| ABSTRACT | Methods, systems, and computer-readable media for processing spatially related sequence data received from a sequencing device are presented. In one or more embodiments, a computing platform may receive, from a sequencing device, image data associated with a sample. The computing platform may identify, based on the image data received from the sequencing device, a first sequence located at first spatial coordinates. Subsequently, the computing platform may store, in a spatially searchable database, a first data element comprising the first spatial coordinates and a first identifier corresponding to the first sequence to spatially relate the first sequence to other sequences present in the sample. In some instances, the image data received from the sequencing device may include spatial information, temporal information, and color information associated with the sample, and the computing platform may present, on a display device, information identifying a presence of the first sequence at the first spatial coordinates. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/157848 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/532 (20190101) Original (OR) Class G06F 16/538 (20190101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/70 (20170101) G06T 7/90 (20170101) G06T 7/187 (20170101) G06T 7/194 (20170101) G06T 2200/04 (20130101) G06T 2207/10056 (20130101) G06T 2207/10148 (20130101) G06T 2207/30024 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 30/00 (20190201) G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162479 | Feng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Xue Feng (Lexington, Kentucky); Quan Chen (Lexington, Kentucky); Kanchan Ghimire (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xue Feng (Lexington, Kentucky); Quan Chen (Lexington, Kentucky); Kanchan Ghimire (Arlington, Virginia) |
| ABSTRACT | The present disclosure relates to a method and apparatus for training a convolutional neural network (CNN) that is robust to missing input information. The method includes: receiving multiple three-dimensional (3D) images per case obtained by different imaging systems such as computed tomography (CT), magnetic resonance (MR), and positron emission tomography (PET); processing the 3D images to fuse the information from multiple imaging modalities; building a deep learning framework using CNNs for image segmentation; adapting the deep learning framework to handle either a single missing input modality or multiple modalities by emulating missing modalities in training; post-processing the output from the deep learning framework to obtain the final segmentation. |
| FILED | Saturday, November 20, 2021 |
| APPL NO | 17/531720 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/80 (20220101) G06V 10/95 (20220101) G06V 10/774 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162816 | Ellington et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Ellington (Austin, Texas); Austin Cole (Austin, Texas); Raghav Shroff (Austin, Texas); Ross Thyer (Austin, Texas) |
| ABSTRACT | A computer-implemented method of training a neural network to improve a characteristic of a protein comprises collecting a set of amino acid sequences from a database, compiling each amino acid sequence into a three-dimensional crystallographic structure of a folded protein, training a neural network with a subset of the three-dimensional crystallographic structures, identifying, with the neural network, a candidate residue to mutate in a target protein, and identifying, with the neural network, a predicted amino acid residue to substitute for the candidate residue, to produce a mutated protein, wherein the mutated protein demonstrates an improvement in a characteristic over the target protein. A system for improving a characteristic of a protein is also described. Improved blue fluorescent proteins generated using the system are also described. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/059180 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 30/00 (20190201) Original (OR) Class G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230157851 | Hansen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); Fraunhofer-Gesellschaft zur Foerderung de Angewandten Forschung e. V. (München, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Hansen (Minneapolis, Minnesota); Sara Koehler-Mcnicholas (Minneapolis, Minnesota); Eric Nickel (Minneapolis, Minnesota); Kyle Barrons (Minneapolis, Minnesota); Felix Starker (München, Germany); Spencer Mion (Minneapolis, Minnesota); John Ferguson (Minneapolis, Minnesota); Stuart Fairhurst (Minneapolis, Minnesota); Ellankavl Ramasamy (München, Germany); Karl Koester (Minneapolis, Minnesota); Urs Schneider (München, Germany) |
| ABSTRACT | Breathable residual-limb system that admits air and allows sweat to evaporate from the surface of the residual limb. In an embodiment, the system comprises a liner sock to be worn on the residual limb, and comprising air-permeable textile forming a substantially cylindrical portion that is closed on a distal end and open on a proximal end and comprising an internal surface and an external surface. The liner sock further comprises a friction-interface material that covers only a portion of the internal surface of the air-permeable textile, such that, when worn on the residual limb, the friction-interface material contacts a surface of the residual limb, and an uncovered portion of the air-permeable textile which the friction-interface material does not cover allows air to pass between an external environment of the liner sock and the surface of the residual limb. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993303 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/80 (20130101) A61F 2/5044 (20130101) A61F 2/7812 (20130101) Original (OR) Class A61F 2002/785 (20130101) A61F 2002/5055 (20130101) A61F 2002/7818 (20130101) A61F 2013/00136 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230157961 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter X. Ma (Ann Arbor, Michigan); Ming Dang (Maple Grove, Minnesota); Laurie K. McCauley (Ann Arbor, Michigan) |
| ABSTRACT | In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099810 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/204 (20130101) A61K 9/205 (20130101) A61K 9/2031 (20130101) Original (OR) Class A61K 9/5031 (20130101) A61K 9/7007 (20130101) A61K 38/29 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158305 | Weber et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Douglas Weber (Pittsburgh, Pennsylvania); Robert Gaunt (Pittsburgh, Pennsylvania); Timothy Bruns (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods and apparatuses for monitoring and regulating physiological states and functions are disclosed. Several embodiments include application of one or more microelectrode arrays to a dorsal root ganglion for measurement of sensory neuron activity, or stimulation of sensory reflex circuits. The methods and apparatuses can be used, for example, for monitoring or controlling bladder function in a patient. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902627 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) A61B 5/112 (20130101) A61B 5/202 (20130101) A61B 5/205 (20130101) A61B 5/1107 (20130101) A61B 5/4064 (20130101) A61B 5/4255 (20130101) A61B 5/4393 (20130101) A61B 5/4519 (20130101) A61B 5/4824 (20130101) A61B 5/4836 (20130101) A61B 5/7246 (20130101) A61B 2560/0223 (20130101) A61B 2562/04 (20130101) A61B 2562/028 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/0551 (20130101) A61N 1/36003 (20130101) A61N 1/36007 (20130101) A61N 1/36062 (20170801) A61N 1/36071 (20130101) A61N 1/36082 (20130101) A61N 1/36107 (20130101) A61N 1/36139 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158441 | Jackson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Jackson (Tucson, Arizona); Raymond S. Lickson (Tucson, Arizona) |
| ABSTRACT | An aeration assembly includes an aeration rod extending along a longitudinal axis between a first end and a second end and having a plurality of longitudinal grooves extending along the longitudinal axis from the first end at least partially to the second end around at least a portion of a circumference of the aeration rod. The aeration assembly also includes an air-activated material adjacent the aeration rod at least along the plurality of longitudinal grooves. The plurality of longitudinal grooves are configured to distribute air from the first end of the aeration rod to the air-activated material adjacent the aeration rod. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532278 |
| CURRENT CPC | Separation B01D 53/261 (20130101) B01D 53/0446 (20130101) Original (OR) Class Ammunition Fuzes; Arming or Safety Means Therefor F42C 99/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158497 | Rubenstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | H. Mitchell Rubenstein (Beavercreek, Ohio); Douglas Adkins (Albuquerque, New Mexico); Patrick Lewis (Albuquerque, New Mexico); John Rogers (Wilmette, Illinois); Sungbong Kim (Champaign, Illinois); Steve Kim (Dayton, Ohio); Michael Brothers (Lebanon, Ohio) |
| ABSTRACT | A system, apparatus, and method include a pump to deliver vapor including airborne contaminants including organic compounds including a target analyte; a collector to transfer the airborne contaminants by autonomous liquid extraction into a mobile organic liquid phase; a micro-fluidic chamber including immobilized biorecognition elements that bind to analytes delivered from the mobile organic liquid phase; a mechanism to introduce the mobile organic liquid phase to a buffer containing a plurality of substrates causing a series of biochemical reactions that create a change corresponding to a concentration of the target analyte; and a detector to perform real-time analysis that correlates to a concentration of the organic compounds to determine a presence of the target analyte. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/151935 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159072 | Bernal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Alexander Bernal (Huntsville, Alabama); Caleb Daniel Rideout (Tumacacori, Arizona); Jacob L. Wymore (Arab, Alabama); Herald Harrington (Clarkdale, Arizona); Kevin Brault (Chandler, Arizona) |
| ABSTRACT | A lift cart includes a lift table that moves between a raised position and a lowest position and a braking device attached to the lift cart. A braking device includes an actuator, a linkage bar, and a first brake assembly. The linkage bar connects to the actuator. The linkage bar translates in a first direction upon activation of the actuator. The first brake assembly connects to the linkage bar. The first brake assembly moves from a deployed state to a retracted state as the linkage bar translates in the first direction. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531422 |
| CURRENT CPC | Hand-propelled Vehicles, e.g Hand Carts or Perambulators; Sledges B62B 3/02 (20130101) Original (OR) Class B62B 5/049 (20130101) B62B 2206/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159149 | Slocum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LTAG SYSTEMS LLC (Bow, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan T. Slocum (Bow, New Hampshire); Alexander Slocum (Bow, New Hampshire) |
| ABSTRACT | According to one aspect, a reactor for generating lifting gas may include a first port, a second port, a coupling releasably securable in fluid communication with an aerostat, and a tank including a base and a crown defining at least a portion of a chamber therebetween, the first port and the coupling each supported on the crown, the second port supported on the tank away from the crown, the chamber in fluid communication with each one of the first port, the second port, and the coupling, the chamber expandable between the crown and the base from an uninflated state to an inflated state and, with the tank in the inflated state, a maximum height of the chamber less than a maximum dimension of the base. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 17/967818 |
| CURRENT CPC | Lighter-than Air Aircraft B64B 1/62 (20130101) Original (OR) Class Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 37/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159156 | Fegely et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TEXTRON INNOVATIONS INC. (Providence, Rhode Island) |
| ASSIGNEE(S) | TEXTRON INNOVATIONS INC. (Providence, Rhode Island) |
| INVENTOR(S) | Cody Fegely (Irving, Texas); Kenneth Stephen Wittmer (Sandy Hook, Connecticut) |
| ABSTRACT | There is disclosed in one example a flight control computer for a rotary aircraft, including: a first interface to communicatively couple to a flight control input; a second interface to communicatively couple to flight geometry actuators; a data source; a multi-dimensional lookup table including a data structure to correlate flight control inputs to flight geometry actuator outputs according to a third-factor; and circuitry and logic instructions to: receive an input via the first interface; query the data source for the third-factor; query the multi-dimensional lookup table for a control input modifier according to the flight control input and the third-factor; and compute and send via a third interface a flight geometry output according to the control input modifier. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/818863 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 13/503 (20130101) Original (OR) Class B64C 27/04 (20130101) B64C 27/57 (20130101) B64C 2027/8209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159340 | KAMYSBAYEV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | VLADISLAV KAMYSBAYEV (Chicago, Illinois); Dmitri V. Talapin (La Grange Park, Illinois) |
| ABSTRACT | Methods for modifying the surface termination of two-dimensional (2D) transition metal carbides (MXenes) are provided. The methods, which allow for versatile chemical modification of the terminating anions via halide exchange or substitution and elimination reactions in molten inorganic salts, provide a processing approach that is widely applicable to MXenes as a broad class of functional materials. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/922848 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/914 (20170801) C01B 32/921 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/20 (20130101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159600 | KHALIL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Ahmad S. KHALIL (Lexington, Massachusetts); Wilson Wai Chun Wong (Brookline, Massachusetts); Divya Israni (Boston, Massachusetts); Huishan Li (Brookline, Maryland) |
| ABSTRACT | The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938787 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) Original (OR) Class C07K 2319/09 (20130101) C07K 2319/20 (20130101) C07K 2319/50 (20130101) C07K 2319/81 (20130101) C07K 2319/715 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159602 | Somasundaram et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Wistar Institute (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajasekharan Somasundaram (Philadelphia, Pennsylvania); Kar Muthumani (Philadelphia, Pennsylvania); David Weiner (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to recombinant optimized polynucleotide encoding a cytokine or cytokine receptor and to methods of making a recombinant optimized polynucleotide encoding a cytokine or cytokine receptor. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937005 |
| CURRENT CPC | Peptides C07K 14/53 (20130101) Original (OR) Class C07K 14/505 (20130101) C07K 14/575 (20130101) C07K 14/715 (20130101) C07K 14/5403 (20130101) C07K 14/5418 (20130101) C07K 14/5443 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159872 | Varone et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio Varone (Cambridge, Massachusetts); Norman Wen (Cambridge, Massachusetts); Daniel Levner (Cambridge, Massachusetts); Richard Novak (Cambridge, Massachusetts); Lori McPartlin (Cambridge, Massachusetts); Donald E. Ingber (Cambridge, Massachusetts); Youngjae Choe (Cambridge, Massachusetts); Lian Leng (Cambridge, Massachusetts); Justin K. Nguyen (Cambridge, Massachusetts) |
| ABSTRACT | A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 18/056035 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) C12M 25/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) C12N 5/0629 (20130101) C12N 5/0656 (20130101) C12N 5/0679 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159920 | Bradley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Robert K. Bradley (Seattle, Washington); Omar Abdel-Wahab (New York, New York); Daichi Inoue (New York, New York) |
| ABSTRACT | The current disclosure relates to methods and compositions for increasing functional expression of BRD9 in a cell. The methods and compositions can be incorporated into methods for treating cancer through the administration of BRD9 activating therapies. Accordingly, aspects of the disclosure relate to compositions and methods for treating cancer, a pre-malignant disease, or a dysplastic disease in a subject. The method can comprise administering a BRD9 activating therapy to the subject. |
| FILED | Thursday, June 25, 2020 |
| APPL NO | 17/621429 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159927 | Gersbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles A. Gersbach (Chapel Hill, North Carolina); Nahid Iglesias (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are fusion proteins for the targeted activation of genes as well as compositions and methods and DMA Targeting Systems comprising the same. The fusion protein may include at least one first polypeptide domain and at least one second polypeptide domain. The first polypeptide domain includes a DMA binding protein, such as a zinc finger protein, a TALE, or a Cas protein, that targets the fusion protein for binding to a specific DNA sequence. The second polypeptide domain includes a modulator of chromatin structure. The fusion protein may further include a third polypeptide domain, the third polypeptide domain including a transcriptional activator domain. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/922751 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159935 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida); GRYPHON BIO THERAPEUTICS, INC. (South San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin K-Wang WANG (Gainesville, Florida); Xiaowei LI (Gainesville, Florida); Weihong TAN (San Ranon, California); Bang WANG (Gainesville, Florida); William HASKINS (South San Francisco, California) |
| ABSTRACT | The lack of blood-brain barrier (BBB) penetrating ability has hindered the delivery of many therapeutic agents for tauopathy therapeutic treatment. A circular bifunctional aptamer reported here has been able to enhance the in vivo BBB penetration for improved therapy. The circular aptamer includes one transferrin receptor (TfR) aptamer to facilitate TfR-aptamer recognition-induced transcytosis across BBB endothelial cells, and one Tau protein aptamer selected to inhibit Tau phosphorylation and other tauopathy-related pathological events in the brain. This bispecific construct exhibits strong specificity towards Tau and enhanced plasma stability in comparison to linear Tau aptamer. In vivo administration of circular Tau-TfR aptamer results in a rapid uptake into relevant brain regions after crossing the BBB, such as hippocampus and cortex. A Y-shaped trispecific aptamer including one aptamer for L1CAM, one aptamer for Tau and one aptamer for TfR reported here has enhanced BBB and neuron cell membrane permeation. Bispecific and trispecific Tau aptamer coupled to a signaling moiety (such as dodecane tetraacetic acid (DOTA) or DOTA complexed to Gd+3) for neuroimaging, and bispecific or trispecific Tau aptamer coupled to protein aggregate binding moiety (such as methylene blue) for enhanced ability to disrupt tau aggregation are also contemplated in this invention. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/797217 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2310/51 (20130101) C12N 2310/532 (20130101) C12N 2310/3513 (20130101) C12N 2310/3517 (20130101) C12N 2310/3519 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159973 | DELISA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew P. DELISA (Ithaca, New York); Aravind NATARAJAN (Menlo Park, California) |
| ABSTRACT | The present application relates to recombinant prokaryotic host cells expressing one or more 4-epimerases, one or more glycosyl-1-phosphate transferases, one or more O-oligosaccharyltransferases, and, optionally, one or more ß1,3-galactosyltransferase enzymes capable of transferring galactose to undecaprenyl pyrophosphate-linked N-Acetylgalactosamine. Also disclosed are methods for producing an O-glycosylated protein. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/920532 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) C12N 9/1048 (20130101) C12N 9/1205 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class Enzymes C12Y 204/01122 (20130101) C12Y 207/0106 (20130101) C12Y 501/03002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159981 | Fleming et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Guild Associates Inc. (Dublin, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ian Fleming (Hilliard, Ohio); Scott V. Angus (Worthington, Ohio); Ada S. Cowan (Delaware, Ohio) |
| ABSTRACT | A device for concentrating and preserving samples for subsequent analysis, wherein the samples include but are not limited to, biological samples, environmental samples, industrial samples, and the like. The present disclosure further includes a method for utilizing the device for containment, concentration, and preservation of the sample until analysis can take place. The disclosed device is simple to operate and can function without auxiliary equipment and/or sources of power making it particularly suitable for use in locations distanced and isolated from analytical facilities. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992790 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159986 | Chiu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Mammoth Biosciences, Inc. (Brisbane, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles Chiu (Oakland, California); Janice Sha Chen (Brisbane, California); Xin Miao (Brisbane, California) |
| ABSTRACT | The disclosure provides methods for characterizing a target DNA present in a sample. The methods involve contacting the sample with one or more universal primers to amplify target DNA; contacting the amplified target DNA with a type V CRISPR/Cas effector protein and one or more guide RNAs, where the contacting generates a cleavage product comprising a 5′ overhang; and ligating a double-stranded nucleic acid adapter to the cleavage product, to generate a ligation product. The ligation product includes the target DNA, which can be sequenced. The sample can be subjected to one or more amplification steps prior to the contacting step, with primers that provide for amplification of nucleic acids of, e.g., specific pathogens, categories of pathogens, two or more different pathogens, or two or more different categories of pathogens. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/920571 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6893 (20130101) C12Q 1/6895 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159996 | Kishi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Jocelyn Yoshiko Kishi (Cambridge, Massachusetts); Brian Beliveau (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts); Yu Wang (Cambridge, Massachusetts); Sinem K. Saka (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein, in some embodiments, are methods and compositions for highly multiplexed in situ signal amplification via hairpin-mediated concatemerization. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/938273 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159998 | PHILLIPS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BIOFIRE DEFENSE, LLC (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cynthia L. PHILLIPS (Salt Lake City, Utah); Kenneth K.C. BRAMWELL (Salt Lake City, Utah); Kirk M. RIRIE (Salt Lake City, Utah); Mark Aaron PORITZ (Salt Lake City, Utah) |
| ABSTRACT | Systems, methods, and apparatus are provided for external control testing of an assay system. |
| FILED | Tuesday, January 29, 2019 |
| APPL NO | 16/965853 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 7/52 (20130101) B01L 2200/16 (20130101) B01L 2300/18 (20130101) B01L 2300/0654 (20130101) B01L 2300/0861 (20130101) B01L 2400/0481 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160018 | Merino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vanessa Ferreira Merino (Townson, Maryland); Martin Pomper (Baltimore, Maryland); Saraswati Sukumar (Columbia, Maryland) |
| ABSTRACT | CKYPB2 induces EMT, sternness, protein synthesis and cell cycle progression through regulation of nucleolin, con-tributing to an increase in tumor growth and metastasis. CKYPB2 can be used as a prognostic marker in African American women with TNBC. CKYPB2 can further select patients with TNBC and ER positive tumors that will likely benefit from inhibitors of ribosomal RNA synthesis, CDK4 and nucleolin. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/919152 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/551 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160042 | PITTARI, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John J. PITTARI, III (Nottingham, Maryland); Steven M. Kilczewski (Belcamp, Maryland); Jeffrey J. Swab (Fallston, Maryland); Kristopher A. Darling (Havre De Grace, Maryland); Billy C. Hornbuckle (Aberdeen, Maryland); Heather A. Murdoch (Baltimore, Maryland); Robert J. Dowding (Abingdon, Maryland) |
| ABSTRACT | A sintered cemented carbide body including tungsten carbide, and a substantially cobalt-free binder including an iron-based alloy sintered with the tungsten carbide. The iron-based alloy is approximately 2-25% of the overall weight percentage of the sintered tungsten carbide and iron-based alloy. The tungsten carbide may be approximately 90 wt % and the iron-based alloy may be approximately 10 wt % of the overall weight percentage of the sintered tungsten carbide and iron-based alloy. The tungsten carbide may comprise a substantially same size before and after undergoing sintering. The iron-based alloy may be sintered with the tungsten carbide using a uniaxial hot pressing process, a spark plasma sintering process, or a pressureless sintering process. The sintered tungsten carbide and iron-based alloy has a hardness value of at least 15 GPa and a fracture toughness value of at least 11 MPa√m. |
| FILED | Friday, August 12, 2022 |
| APPL NO | 17/886949 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/14 (20130101) B22F 3/105 (20130101) Alloys C22C 1/051 (20130101) C22C 29/02 (20130101) Original (OR) Class C22C 29/08 (20130101) C22C 29/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160661 | Cole et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Aaron Cole (Bloomington, Indiana); John D. Rodriguez (San Diego, California) |
| ABSTRACT | Provided is a tool for providing long distance shooters with the ability to receive information from others in the field to adjust their weapon system for the best advantage based on distance, location, and range. The tool may implemented as an application on a mobile device such as a smart phone, for example, making the tool light weight, space efficient, and portable for use in the field. The communication ability allows for tracking shooting partners as well as on-the-spot coordination. The tool further provides range markings, yard lines, and topographic data that allow the shooter to make decisions based on real time data. Shooters are therefore afforded a tool that is portable, easy to use, and flexible enough to use in high-pressure environments. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977299 |
| CURRENT CPC | Weapon Sights; Aiming F41G 3/165 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230160666 — Composite Enclosure for Explosive Reactive Armor and Methods of Manufacturing the Same
| US 20230160666 | Klann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Shawn C. Klann (Warren, Michigan); Frederick C. Rickert, II (Royal Oak, Michigan); David B. Witherspoon (Port Huron, Michigan); William T. Hoffman (Howell, Michigan) |
| ABSTRACT | An explosive reactive armor (ERA) enclosure for an ERA tile includes a bottom and a plurality of sidewalls extending from the bottom, where the plurality of sidewalls are continuous with each other and with the bottom so as to define an internal volume. The plurality of sidewalls are formed from a fiber-reinforced composite material having a plurality of plies of fiber sheet material. Additionally, a sidewall seam defined by abutting edges of the first ply is offset from a sidewall seam defined by abutting edges of the second ply. Methods of manufacturing ERA enclosures, including applying wrap layers and forming attachment structures for securing the fiber-reinforced composite ERA enclosure to an armor element, are also described. The composite enclosure is inexpensive and lightweight and improves the dynamic capabilities of armored vehicles using such ERA tiles. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/084314 |
| CURRENT CPC | Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/007 (20130101) Original (OR) Class F41H 5/013 (20130101) F41H 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160670 | Skalny et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | David Anthony Skalny (Shelby Township, Michigan); John Michael Zwally (Canton, Michigan); Byron Chan Wong (Sterling Heights, Michigan); Alexander William Hundich (Royal Oak, Michigan); Edward Thomas O'Connell, III (Lynn Township, Michigan) |
| ABSTRACT | A target stand is described that may comprise a frame; first and second rails; and a trolley. The frame may support the first and second rails. The trolley may comprise a base, a first wheel assembly coupled to the base and in contact with the first rail, and a second wheel assembly coupled to the base and in contact with the second rail, wherein the trolley is movable between respective lower ends of the first and second rails and respective upper ends of the first and second rails via the first and second wheel assemblies contacting the first and second rails. The base of the trolley may comprise a proximal portion and a cantilevered portion extending away from the proximal portion to a free end, wherein the first and second wheel assemblies are coupled to the proximal portion and the cantilevered portion extends over the first and second rails. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532145 |
| CURRENT CPC | Targets; Target Ranges; Bullet Catchers F41J 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160682 | GILBERT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Noah GILBERT (Waltham, Massachusetts); Joshua BROWN (Newton, Massachusetts) |
| ABSTRACT | A polarization-separated, phase-shifted interferometer can generate interferograms without moving parts. It uses a phase shifter, such as an electro-optic phase modulator, to modulate the relative phase between sample and reference beams. These beams are transformed into orthogonal polarization states (e.g., horizontally and vertically polarized states) and coupled via a common path (e.g., polarization-maintaining fiber) to a polarizing beam splitter (PBS), which sends them into separate sample and reference arms. Quarter-wave plates in the sample and reference arms rotate the polarization states of the sample and reference beams so they are coupled out of the PBS to a detector via a 45° linear polarizer. The polarizer projects the aligned polarization components of the sample and reference beams onto the detector, where they interfere with known relative phase to produce an output that can be used to map surface topography of the test object. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572353 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/0201 (20130101) Original (OR) Class G01B 9/02067 (20130101) G01B 11/2441 (20130101) G01B 2290/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160817 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongming Li (Notre Dame, Indiana); Gregory Hartland (Granger, Indiana); Masaru Ken Kuno (Notre Dame, Indiana) |
| ABSTRACT | Mid-infrared photothermal heterodyne imaging (MIR-PHI) techniques described herein overcome the diffraction limit of traditional MIR imaging and uses visible photodiodes as detectors. MIR-PHI experiments are shown that achieve high sensitivity, sub-diffraction limit spatial resolution, and high acquisition speed. Sensitive, affordable, and widely applicable, photothermal imaging techniques described herein can serve as a useful imaging tool for biological systems and other submicron-scale applications. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/149245 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/35 (20130101) G01N 21/171 (20130101) G01N 21/3563 (20130101) Original (OR) Class G01N 2021/1712 (20130101) G01N 2021/1714 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/02 (20130101) G01Q 60/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160950 | Krishnamoorthy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas); NSWC Crane (Crane, Indiana) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); NSWC Crane (Crane, Indiana) |
| INVENTOR(S) | Harish Krishnamoorthy (Missouri City, Texas); Joshua Hawke (Bloomington, Indiana) |
| ABSTRACT | The systems and methods described herein are for remaining useful life prediction in electronics and include measuring a plurality of circuit parameters for each of a plurality of circuit components at a plurality of different temperatures, determining a probability density function of failure as a function of time for each of the plurality of circuit components and combining the probability density functions for each of the plurality of circuit components as a function of a circuit that contains the plurality of circuit components. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/961803 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2834 (20130101) Original (OR) Class G01R 31/2837 (20130101) G01R 31/2844 (20130101) G01R 31/2846 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161059 | Penny et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Decision Sciences International Corporation (Poway, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert D. Penny (San Diego, California); Michael James Sossong (Ramona, California); Matthew Steiger (El Cajon, California); Young K. Lee (San Diego, California) |
| ABSTRACT | A volume interrogation system can use an accelerated beam of charged particles to interrogate objects using charged-particle attenuation and scattering tomography to screen items such as portable electronic devices, packages, baggage, industrial products, or food products for the presence of materials of interest inside. The exemplary systems and methods in this patent document can be employed in checkpoint applications to scan items. Such checkpoint applications can include border crossings, mass transit terminals (subways, buses, railways, ferries, etc.), and government and private-sector facilities. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/986349 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 5/08 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/32 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/001 (20130101) H05H 7/04 (20130101) H05H 13/00 (20130101) H05H 2007/002 (20130101) H05H 2007/045 (20130101) H05H 2277/1405 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161069 | Ulmer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTELLISENSE SYSTEMS, INC. (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Ulmer (San Pedro, California); Jeremy Frank (Redondo Beach, California); David Miller (San Pedro, California); Jeffrey Norell (Los Angeles, California); David Gustavson (Los Angeles, California); Gregory Peng (Long Beach, California); Matthew Barnhart (Seal Beach, California); Thomas Vu (Rancho Palos Verdes, California) |
| ABSTRACT | An assembly and method for using weather sensors with enhanced modular capability is disclosed. The weather sensor assembly generally comprises a cap module, middle module, and a base module, where the cap module, middle module(s) and the base module are stacked adjacently to provide environmental sealing, weather sensing, and electrical connectivity to the weather sensor assembly. One or more ring mechanisms may be included that interlock the cap module, middle module(s), base module to form the weather sensor assembly into an integrated unit. Moreover, the ring mechanisms enable further modules to be added to the weather sensor assembly for additional capabilities. By doing so, each of the modules in the weather sensor assembly may be independent units that can be removed, reordered, swapped, and added for desired sensing modalities and environments. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099757 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/42 (20130101) G01S 17/95 (20130101) Meteorology G01W 1/02 (20130101) Original (OR) Class G01W 1/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161172 | Braunreiter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis Braunreiter (San Diego, California); Aaron Stonely (McKinney, Texas); Daniel Young (Allen, Texas) |
| ABSTRACT | A system includes a high energy laser (HEL) configured to transmit a HEL beam and a beacon illumination laser (BIL) configured to transmit a BIL beam. The system also includes at least one fast steering mirror (FSM) configured to steer the BIL beam to be offset from the HEL beam. The system further includes at least one Coudé path FSM configured to correct for atmospheric jitter of the HEL beam and the BIL beam while maintaining the offset of the BIL beam from the HEL beam. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/157645 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/90 (20200101) Optical Elements, Systems, or Apparatus G02B 26/0816 (20130101) G02B 27/648 (20130101) Original (OR) Class Transmission H04B 10/1125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161219 | McManamon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Exciting Technology LLC (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul F. McManamon (Dayton, Ohio); Abtin Ataei (Oakwood, Ohio) |
| ABSTRACT | A device may include a high-side electrode layer comprising a plurality of discrete electrodes. A device may include a low-side electrode layer. A device may include an electro-optic (EO) layer comprising a solid EO active material at least partially interposed between the high-side electrode layer and the low-side electrode layer, thereby forming a plurality of active cells of the EO layer. A device may include a controller, comprising: a steering request circuit structured to interpret a steering request value, a steering configuration circuit structured to determine a plurality of EO command values in response to the steering request value; and a steering implementation circuit structured to provide a plurality of voltage commands in response to the plurality of EO command values. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/973261 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/139 (20130101) G02F 1/292 (20130101) G02F 1/311 (20210101) G02F 1/3133 (20130101) Original (OR) Class G02F 1/3138 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161639 | Vega et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Augusto Vega (Mount Vernon, New York); Alper Buyuktosunoglu (White Plains, New York); Pradip Bose (Yorktown Heights, New York); Vaidyanathan Srinivasan (Bangalore, India); Ranjal Gautham Shenoy (Bangalore, India) |
| ABSTRACT | Systems, computer-implemented methods and/or computer program products that facilitate management of resources are provided. In one embodiment, a computer-implemented method comprises: employing, by a system operatively coupled to a processor, at least one model to predict respective token needs by a set of processing elements during execution of a workload; and exchanging, by the system, one or more tokens between a subset of the processing elements as a function of the predicted token needs. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/150894 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5044 (20130101) G06F 9/5061 (20130101) G06F 9/5083 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/043 (20130101) G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161822 | Agrawal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dakshi Agrawal (Monsey, New York); Raghu K. Ganti (Elmsford, New York); Mudhakar Srivatsa (White Plains, New York); Petros Zerfos (New York, New York) |
| ABSTRACT | A system and method are provided for discovering k-nearest-neighbors to a given point within a certain distance d. The method includes constructing an index of geometries using geohashes of geometries as an indexing key to obtain an indexed set of geometries, and calculating a geohash representation of the given point with a resolution equal to a magnitude value of d. The method includes searching for a closest-prefix geometry from the indexed set using the geohash representation of the given point, and identifying geometries from the indexed set having a same prefix as the closest-prefix geometry. The method further includes calculating distances between the given point and the geometries identified from the indexed set having the same prefix as the closest-prefix geometry, and determining k geometries with respective shortest distances less than d from the geometries identified from the indexed set having the same prefix as the closest-prefix geometry. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/150950 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/29 (20190101) G06F 16/9014 (20190101) G06F 16/90344 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161892 | Mosko |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Marc E. Mosko (Kensington, California) |
| ABSTRACT | A system and method are provided to facilitate securing windows discretionary access control. During operation, the system determines a Windows domain model including capability assignments of principals on resources, wherein a respective capability assignment comprises a permission of a respective principal to a respective resource and wherein a respective principal comprises a user or a group of users. The system specifies desired effective permissions of each principal to each resource. The system generates, based on the specified desired effective permissions, access control entries for the respective principal to the respective resource. The system generates, based on the specified desired effective permissions, group memberships indicating which users belong to which groups. |
| FILED | Wednesday, August 31, 2022 |
| APPL NO | 17/900458 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/45 (20130101) G06F 21/6218 (20130101) Original (OR) Class G06F 2221/2141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162074 | DEBNATH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); IonQ, Inc. (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shantanu DEBNATH (College Park, Maryland); Norbert M. LINKE (Stevenson, Maryland); Christopher R. MONROE (Columbia, Maryland); Caroline FIGGATT (Denver, Colorado) |
| ABSTRACT | Aspects of the present disclosure describe techniques for controlling quantum states of ions in an ion chain for a quantum operation. For example, a method is described that includes providing, from a first direction, a global optical beam to the ions in the ion chain, and providing, from a second direction different from the first direction, to each ion in a subset of the ions in the ion chain, a respective addressing optical beam. The method further includes dynamically controlling each of the addressing optical beams being provided by using a respective channel in a multi-channel acousto-optic modulator (AOM) to implement, with the ion chain, one or more quantum gates in a sequence of quantum gates of the quantum operation. Aspects of a quantum information processing (QIP) system that includes the multi-channel AOM for performing the method are also described. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/969258 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/113 (20130101) G02F 1/116 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162432 | Youngblood et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory M. Youngblood (Minden, Nevada); Matthew Shreve (Mountain View, California); Mark J. Stefik (Portola Valley, California); Robert Thomas Krivacic (San Jose, California); Lester D. Nelson (Santa Clara, California); Jacob Le (Palo Alto, California) |
| ABSTRACT | A system and method for translating a 2D image to a 3D image is provided. A 2D image having pixels grouped into tiles is obtained. Contour lines associated with an altitude value are located on the 2D image. The altitude values are determined. Each tile in the 2D image is represented using at least one voxel. A height map of the voxels is generated based on the contour lines and altitude values as a base layer for a 3D image. A terrain type of each of the voxels of the 3D image is determined and objects are placed in the 3D image. The 3D image is output. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/152068 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 15/04 (20130101) G06T 15/10 (20130101) Original (OR) Class G06T 15/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162758 | Borgstrom et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bengt J. Borgstrom (Lexington, Massachusetts); Michael S. Brandstein (Acton, Massachusetts) |
| ABSTRACT | A neural network-based end-to-end single-channel speech enhancement system designed for joint suppression of noise and reverberation, which can include attention masking. The neural network architecture can contain both an enhancement and an autoencoder path, so that disabling the masking mechanism causes reconstruction of the input speech signal. The autoencoder path and the enhancement can be simultaneously trained using a loss function that includes a perceptually-motivated waveform distance measure. Examples enable dynamic control of the level of suppression applied via a minimum gain level. A novel loss function can be utilized to simultaneously train both the enhancement and the autoencoder paths, which includes a perceptually-motivated waveform distance measure. Examples provide significant levels of noise suppression while maintaining high speech quality. Examples can also improve the performance of automated speech systems, such as speaker and language recognition, when used as a pre-processing step. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991473 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/24 (20130101) G10L 25/30 (20130101) G10L 25/84 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162816 | Ellington et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Ellington (Austin, Texas); Austin Cole (Austin, Texas); Raghav Shroff (Austin, Texas); Ross Thyer (Austin, Texas) |
| ABSTRACT | A computer-implemented method of training a neural network to improve a characteristic of a protein comprises collecting a set of amino acid sequences from a database, compiling each amino acid sequence into a three-dimensional crystallographic structure of a folded protein, training a neural network with a subset of the three-dimensional crystallographic structures, identifying, with the neural network, a candidate residue to mutate in a target protein, and identifying, with the neural network, a predicted amino acid residue to substitute for the candidate residue, to produce a mutated protein, wherein the mutated protein demonstrates an improvement in a characteristic over the target protein. A system for improving a characteristic of a protein is also described. Improved blue fluorescent proteins generated using the system are also described. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/059180 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 30/00 (20190201) Original (OR) Class G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162965 | Cooks |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for conducting reactions and screening for reaction products. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/101265 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0013 (20130101) H01J 49/165 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163549 | Helle |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Michael H. Helle (Arlington, Virginia) |
| ABSTRACT | A fully programmable laser field shaping apparatus that can configure a beam of laser pulses in both shape and time to generate laser pulses with varying spatio-temporal profiles for adaptive nonlinear optical propagation. The laser field shaping scheme in accordance with the present invention, Adaptive Spatio-Temporal Optical Pulse Shaper (A-STOPS), utilizes dispersive elements and a programmable spatial varying optical element (e.g. deformable mirror, spatial light modulator, etc.) to impose spatial variations on each frequency component of a laser pulse. Each frequency component maps directly to a temporal slice within a chirped laser pulse. The result is the ability to generate complex spatio-temporal variation on a laser pulse with wide ranging applications in linear and nonlinear optics. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 18/050063 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163571 | LYAKH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (ORLANDO, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ARKADIY LYAKH (OVIEDO, Florida); MATTHEW SUTTINGER (Orlando, Florida) |
| ABSTRACT | A QCL may include a substrate, and a sequence of semiconductor epitaxial layers adjacent the substrate and defining an active region, an injector region adjacent the active region, and a waveguide optically coupled to the active region. The active region may include stages, each stage having an upper laser level and a lower laser level defining respective first and second wave functions. The upper laser level may have an upper laser level average coordinate, and the lower laser level may have a lower laser level average coordinate. The upper laser level average coordinate and the lower laser level average coordinate may have spacing of less than 10 nm. Wave functions for all active region energy levels located below the lower laser level may have greater than 10% overlap with the injector region. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938817 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/20 (20130101) H01S 5/22 (20130101) H01S 5/026 (20130101) H01S 5/3402 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163829 | Learned |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachel E. Learned (Waltham, Massachusetts) |
| ABSTRACT | In some embodiments, a method for mitigating interference in a channel having multiple users includes: transmitting, by a transmitter, a signal of interest (SOI) to a sequential interference cancellation (SIC) receiver at a transmit power; determining a packet drop rate as seen by the receiver; and decreasing the transmit power in response to determining the packet drop rate exceeds a predetermined maximum packet drop rate. The transmitter's coding rate and/or modulation level may also be lowered based on the decrease in transmit power. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 16/880410 |
| CURRENT CPC | Wireless Communication Networks H04W 52/241 (20130101) H04W 52/367 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163848 | Buen |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Josh Buen (Washington, District of Columbia) |
| ABSTRACT | Methods, systems, and devices to realize Quality of Service (QoS) in a Free Space Optics (FSO) communications link. In operation, the application generating the data source assigns a QoS value to each data packet for optical transmission. The FSO system converts this value to a QoS metric based on the capability of the system to synthesize transmit signals of varying bandwidths. The QoS modulator synthesizes a waveform with bandwidth selected by the QoS metric. This implementation may take the form of time-division multiplexing either at the intra- or inter-packet level; there are fixed time intervals arranged between the transmit and receive FSO systems for specific waveform bandwidths. The transmit and receive process continues in a typical fashion until the signal reaches the QoS optical receiver followed by the QoS demodulator. Here the bandwidth set by the QoS metric is accounted for in either the analog or digital domain and the recovery of the original data source follows. This process provides the advantage of improved resiliency of critical networking packets in an FSO communications link. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992867 |
| CURRENT CPC | Transmission H04B 10/112 (20130101) Original (OR) Class Selecting H04Q 11/0062 (20130101) H04Q 2011/0084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163853 | Pascoguin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bienvenido Melvin L. Pascoguin (San Diego, California); Brittany Lynn (San Diego, California) |
| ABSTRACT | A system for electromagnetic communication with a vortex beam concurrently conveys multiple topological charges of orbital angular momentum. The system includes a source, at least one vortex-sensing diffraction grating, and an array of photodetectors. The source generates the vortex beam concurrently conveying a respective number of selected topological charges during each of the time intervals. The selected topological charges for each time interval are selected from a set of available topological charges. The selected topological charges for each time interval encode a symbol of data. The vortex-sensing diffraction grating combines a vortex phase pattern and a linear phase pattern. The vortex sensing diffraction grating produces a diffraction pattern from diffracting the vortex beam received from the source. The array of photodetectors detects portions of the diffraction pattern and from the detected portions recovers the selected topological charges encoding the symbol of each time interval. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/535281 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/4233 (20130101) Transmission H04B 10/27 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163980 | Cambou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bertrand F. Cambou (Flagstaff, Arizona); Donald Telesca (Rome, New York); H. Shelton Jacinto (Rome, New York) |
| ABSTRACT | Methods and systems for managing access to encrypted digital files are proposed. A remote or client device including an array of physical unclonable function (PUF) devices is provided. A server device has an image of the PUF, with previously measured responses. The server device randomly selects a set of responses from a first list PUF devices in its image. The server device then generates masking data to select among the first list to generate response bitstream. The response bitstream is used to encrypt a file, which sent to the client for storage. The random number is also sent. Later, the server generates an encrypted message digest from which the client can retrieve the masking data, which is used with the random number to generate a response bitstream from the client PUF to decrypt the file. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991706 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0869 (20130101) H04L 9/3278 (20130101) Original (OR) Class H04L 63/0428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230164410 | Holmes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Richard B. Holmes (Albuquerque, New Mexico); Steven F. Griffin (Kihei, Hawaii) |
| ABSTRACT | A retrofittable subassembly that enhances the operational availability of a terrestrial optical surveillance system is disclosed. In various embodiments, the subassembly comprises a diffusely reflective and insulating external cover, a highly uniform plate-glass cover, an wide angle FOV camera and a passive thermal control system. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499564 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 23/51 (20230101) H04N 23/52 (20230101) H04N 23/55 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230157587 | Javey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ali Javey (Lafayette, California); Hnin Yin Yin Nyein (Berkeley, California); Brandon Nguyen K. Tran (Garden Grove, California) |
| ABSTRACT | In certain embodiments a microfluidic patch is provided that allows continuous analysis of natural sweat at various body locations of sedentary individuals. In certain embodiments the patch provides integrated electrical sweat rate sensor and electrochemical sensors to enable simultaneous detection of sweat rate and compositions such as pH, Cl−, and levodopa. The patch can facilitate dynamic sweat analysis related to light physical activities, hypoglycemia-induced sweating, and levodopa sensing for Parkinson's disease management. The device enables routine analysis of natural sweat dynamics arising from different physical and physiological functions which cannot be realized by current wearable sweat sensors. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/919983 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1477 (20130101) A61B 5/6833 (20130101) A61B 5/14517 (20130101) Original (OR) Class A61B 5/14546 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158149 | Pruitt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beth L. Pruitt (Santa Barbara, California); Erica A. Castillo (Santa Barbara, California); Anna Kim (Santa Barbara, California); Gabriela Villalpando Torres (Santa Barbara, California); Kerry V. Lane (Santa Barbara, California) |
| ABSTRACT | A method for performing protein patterning is provided. In particular, the method comprises generating a photoresist pattern on a wafer using photolithography; dicing the photoresist patterned wafer into wafer chips; and performing lift-off protein patterning on the photoresist patterned wafer chips. This manufacturing technique scales up the photolithography stage of the lift-off fabrication workflow to generate high quantities of shelf-stable photoresist patterned glass substrates, which can be used to incorporate a protein pattern onto the surface of a hydrogel. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/972306 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/42 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158321 | SHELTRAW et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DANIEL J. SHELTRAW (ALBANY, California); BENJAMIN A. INGLIS (Lafayette, California); RICHARD IRWIN IVRY (El Cerrito, California); LUDOVICA LABRUNA (Kensington, California) |
| ABSTRACT | A magnetic stimulation system has at least two magnetic coils, each coil to generate an induced electric field of a magnitude having a desired effect on a brain, at least two frequency controllers, wherein each coil is electrically connected to a corresponding frequency controller, the frequency controllers to adjust a frequency of power supplied to the corresponding coils according to a desired interference pattern, and at least one power source to provide power to the frequency controllers corresponding to each coil. A method of operating a magnetic stimulation system includes generating two or more signals to apply to two or more coils, each signal corresponding to one of the at least two coils, wherein at least two coils receive different signals and the different signals differ at least in frequency according to a desired temporal interference pattern. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/921563 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/40 (20130101) A61N 2/02 (20130101) A61N 2/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158474 | WEI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei David WEI (Gainesville, Florida); Jiawei HUANG (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides for methods for designing and constructing metal/semiconductor heterostructures as catalysts for a wide range of applications such as oxygen activation. In a particular aspect, the present disclosure provides for the manipulation of atomic structures at MJ/TiO2 interface (e.g., Au/TiO2 interface) that significantly alters the interfacial electron distribution and prompts O2 activation. In an aspect, the present disclosure provides for a M/TiO2 composites (e.g., heterostructures) having a N defect-free M/TiO2 interface and method of making the M/TiO2 composites having a defect-free M/TiO2 interface. The M can be Au, Ag, Cu, Al, Pt, Ni, or Pd, for example. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/917163 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/063 (20130101) Original (OR) Class B01J 23/52 (20130101) B01J 35/0013 (20130101) B01J 37/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158495 | KANSO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eva KANSO (Los Angeles, California); Janna NAWROTH (Munich, Germany); Feng LING (Los Angeles, California); Kakani Katija YOUNG (Carmel Valley, California); Margaret Jean McFALL-NGAI (Kailua, Hawaii); Michael SHELLEY (Los Angeles, California) |
| ABSTRACT | A method for designing a microfluidic device includes steps of: a) receiving an input design of a bare microfluidic channel to which one or more cilia layers are to be added, the bare microfluidic channel having a predetermined cross section, the bare microfluidic channel defining an inner surface and an outer surface, a first direction being a fluid flow direction along a length of the bare microfluidic channel and a second direction perpendicular to the first direction; b) receiving operation parameters for a ciliated microfluidic channel formed from the bare microfluidic channel, the operation parameters including fluid viscosity and an opposing pressure gradient in an adverse direction to the fluid flow direction; and c) determining cilia design parameters for the one or more cilia layers to be attached to and distributed over the inner surface, the cilia design parameters being determined from the incompressible Brinkman equation. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947837 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 3/502707 (20130101) B01L 2300/16 (20130101) B01L 2300/0645 (20130101) B01L 2400/043 (20130101) B01L 2400/0493 (20130101) Electric Digital Data Processing G06F 30/28 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159340 | KAMYSBAYEV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | VLADISLAV KAMYSBAYEV (Chicago, Illinois); Dmitri V. Talapin (La Grange Park, Illinois) |
| ABSTRACT | Methods for modifying the surface termination of two-dimensional (2D) transition metal carbides (MXenes) are provided. The methods, which allow for versatile chemical modification of the terminating anions via halide exchange or substitution and elimination reactions in molten inorganic salts, provide a processing approach that is widely applicable to MXenes as a broad class of functional materials. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/922848 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/914 (20170801) C01B 32/921 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/20 (20130101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159346 | Sant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav N. Sant (Los Angeles, California); Laurent G. Pilon (Los Angeles, California); Erika Blanca Callagon La Plante (Los Angeles, California); Bu Wang (Los Angeles, California); Zongsu Wei (Los Angeles, California); Sara Vallejo Castaño (Los Angeles, California) |
| ABSTRACT | Divalent ions are extracted from solids by leaching to form a divalent ion-containing solution. The divalent ion-containing solution is subjected to concentration to form a concentrated divalent ion-containing solution. Precipitation of a divalent ion hydroxide salt is induced from the concentrated divalent ion-containing solution. In other cases, the concentrated divalent ion-containing solution is exposed to carbon dioxide to induce precipitation of a divalent ion carbonate salt. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100283 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 5/22 (20130101) C01F 5/24 (20130101) C01F 5/145 (20130101) C01F 11/005 (20130101) C01F 11/16 (20130101) C01F 11/181 (20130101) Original (OR) Class C01F 11/185 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/66 (20130101) C02F 1/441 (20130101) C02F 1/442 (20130101) C02F 1/4691 (20130101) C02F 1/5236 (20130101) C02F 9/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159390 | Fini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Elham Fini (Phoenix, Arizona); Amirul Islam Rajib (Tempe, Arizona); Shuguang Deng (Mesa, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elham Fini (Phoenix, Arizona); Amirul Islam Rajib (Tempe, Arizona); Shuguang Deng (Mesa, Arizona) |
| ABSTRACT | A composite including a polymeric material or emulsion and biochar. The composite includes 1 wt % to 20 wt % of the biochar. Making the composite includes combining biochar with a polymeric material or emulsion to yield a modified polymeric material or emulsion, and homogenizing the modified polymeric material or emulsion to yield the composite. Functionalizing biochar includes removing contaminants from the biochar to yield decontaminated biochar, oxidizing the decontaminated biochar to yield oxidized biochar, and functionalizing the oxidized biochar. Making nitrogen-doped biochar includes combining urea and wood residue to form a mixture, and heating the mixture in an oxygen-free environment to form the nitrogen-doped biochar. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993355 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/192 (20170801) C01B 32/198 (20170801) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 18/101 (20130101) Original (OR) Class C04B 18/0481 (20130101) C04B 20/023 (20130101) C04B 26/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159435 | Gopalan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Padma Gopalan (Madison, Wisconsin); Balamurugan Ayyakkalai (Madison, Wisconsin); Ri Chen (Madison, Wisconsin) |
| ABSTRACT | Formamide group-containing monomers and polymers made by polymerizing the monomers are provided. Also provided are methods of polymerizing the monomers and methods of synthesizing functionalized polymers by pre- and/or post-polymerization functionalization. The monomers are non-toxic and can generate highly reactive isocyanate and isonitrile precursors in a one-pot synthesis that enables the incorporation of complex functionalities into the side-chain of the polymers that are synthesized from the monomers. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/149345 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 225/14 (20130101) C07C 225/16 (20130101) Original (OR) Class C07C 2602/42 (20170501) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 12/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159595 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Baker (Seattle, Washington); Jacob B. BALE (Seattle, Washington); Neil P. KING (Seattle, Washington); William H. SHEFFLER (Seattle, Washington); Daniel ELLIS (Seattle, Washington) |
| ABSTRACT | Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/934343 |
| CURRENT CPC | Peptides C07K 14/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159600 | KHALIL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Ahmad S. KHALIL (Lexington, Massachusetts); Wilson Wai Chun Wong (Brookline, Massachusetts); Divya Israni (Boston, Massachusetts); Huishan Li (Brookline, Maryland) |
| ABSTRACT | The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938787 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) Original (OR) Class C07K 2319/09 (20130101) C07K 2319/20 (20130101) C07K 2319/50 (20130101) C07K 2319/81 (20130101) C07K 2319/715 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159678 | Bowman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher N. Bowman (Boulder, Colorado); Dillon Love (Monroe, North Carolina) |
| ABSTRACT | Provided herein are methods of using aryl thiols as photoinitiators. The thiol compounds are useful as oxygen insen-sitive photoinitiators for applications such as bulk polymerizations and for specialty polymer synthesis by preparing aromatic thiol functionalized macroinitiators. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 18/011106 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 120/12 (20130101) C08F 120/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159690 | Ellison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. Ellison (Eden Prairie, Minnesota); Marc A. Hillmyer (Minneapolis, Minnesota); Hee Joong Kim (Minneapolis, Minnesota) |
| ABSTRACT | Polymers, including homopolymers, copolymers, block copolymers, comprising poly(pentadecyl caprolactone), methods of making the polymers, and pressure sensitive adhesives including the polymers. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/917848 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 293/00 (20130101) Original (OR) Class Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 167/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159841 | Cholli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Polnox Corporation (Lowell, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashok L. Cholli (Lowell, Massachusetts); Murat Tonga (Arlington, Massachusetts) |
| ABSTRACT | Disclosed are multifunctional compounds represented by structural formula (I): methods of producing compounds represented by structural formula (I) and their use in inhibiting corrosion in corrodible material. |
| FILED | Thursday, January 12, 2023 |
| APPL NO | 18/096281 |
| CURRENT CPC | Edible Oils or Fats, e.g Margarines, Shortenings, Cooking Oils A23D 7/00 (20130101) A23D 9/00 (20130101) Acyclic or Carbocyclic Compounds C07C 67/08 (20130101) C07C 67/14 (20130101) C07C 69/604 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/19 (20130101) C10L 1/1905 (20130101) C10L 1/1981 (20130101) C10L 10/04 (20130101) Original (OR) Class Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 129/72 (20130101) C10M 169/04 (20130101) C10M 169/041 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2030/64 (20200501) Fatty Acids From Fats, Oils or Waxes; Candles; Fats, Oils or Fatty Acids by Chemical Modification of Fats, Oils, or Fatty Acids Obtained Therefrom C11C 3/003 (20130101) Detergent Compositions; Use of Single Substances as Detergents; Soap or Soap-making; Resin Soaps; Recovery of Glycerol C11D 3/0073 (20130101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 11/128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159876 | Skerlos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Skerlos (Ann Arbor, Michigan); Lutgarde Raskin (Ann Arbor, Michigan); Timothy Fairley-Wax (Ann Arbor, Michigan); Nishant Jalgaonkar (Ann Arbor, Michigan) |
| ABSTRACT | The disclosure relates to bioreactors, for example for biological treatment and, more specifically to bioreactor insert apparatus including biofilms and related methods. The bioreactor insert apparatus provides a means for circulation of reaction medium within the bioreactor, a biofilm support, and biological treatment of an inlet feed to die reactor/insert apparatus. The bioreactor insert apparatus has a high relative surface area for biofilm attachment and is capable of generating complex flow patterns and increasing treatment efficiency/biological conversion activity in a biologically-active reactor. The high surface area structure incorporates multiple biofilm support structures such as meshes at inlet and outlet portions of the structure. The biofilm support structures and biofilms thereon can increase overall reaction rate of the bioreactor and/or perform some solid/liquid separation in the treatment of the wastewater or other influent. |
| FILED | Thursday, January 12, 2023 |
| APPL NO | 18/153689 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/10 (20130101) C02F 3/1268 (20130101) C02F 3/2806 (20130101) C02F 3/2853 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/06 (20130101) C12M 25/00 (20130101) C12M 27/14 (20130101) C12M 29/26 (20130101) Original (OR) Class C12M 33/14 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159927 | Gersbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles A. Gersbach (Chapel Hill, North Carolina); Nahid Iglesias (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are fusion proteins for the targeted activation of genes as well as compositions and methods and DMA Targeting Systems comprising the same. The fusion protein may include at least one first polypeptide domain and at least one second polypeptide domain. The first polypeptide domain includes a DMA binding protein, such as a zinc finger protein, a TALE, or a Cas protein, that targets the fusion protein for binding to a specific DNA sequence. The second polypeptide domain includes a modulator of chromatin structure. The fusion protein may further include a third polypeptide domain, the third polypeptide domain including a transcriptional activator domain. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/922751 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159948 | Weiss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ron Weiss (Newton, Massachusetts); Ross D. Jones (Cambridge, Massachusetts); Breanna E. DiAndreth (Cambridge, Massachusetts); Domitilla Del Vecchio (Cambridge, Massachusetts); Yili Qian (Madison, Wisconsin) |
| ABSTRACT | The present disclosure, at least in part, relates to an engineered incoherent feed forward loop (iFFL) comprising a first transcription unit encoding an endoribonuclease and a second transcription unit encoding an output molecule and an endoribonuclease target site located in the 5′ UTR of the output molecule coding sequence. The engineered iFFL, at least in part, can be used for sustained expression of an output molecule despite of transcription resource disturbance in a given environment. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/153276 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2830/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159972 | Jewett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); Cornell Univerwsity (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Jessica Carol Stark (Evanston, Illinois); Matthew P. DeLisa (Ithaca, New York); Thapakorn Jaroentomeechai (Ithaca, New York) |
| ABSTRACT | Disclosed are components and systems for cell-free glycoprotein synthesis (CFGpS). In particular, the components and systems include and utilize prokaryotic cell lysates from engineered prokaryotic cell strains that have been engineered to enable cell-free synthesis of glycoproteins. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/811051 |
| CURRENT CPC | Peptides C07K 14/473 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/52 (20130101) C12N 15/62 (20130101) C12N 2330/50 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/18 (20130101) C12P 21/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159973 | DELISA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew P. DELISA (Ithaca, New York); Aravind NATARAJAN (Menlo Park, California) |
| ABSTRACT | The present application relates to recombinant prokaryotic host cells expressing one or more 4-epimerases, one or more glycosyl-1-phosphate transferases, one or more O-oligosaccharyltransferases, and, optionally, one or more ß1,3-galactosyltransferase enzymes capable of transferring galactose to undecaprenyl pyrophosphate-linked N-Acetylgalactosamine. Also disclosed are methods for producing an O-glycosylated protein. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/920532 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) C12N 9/1048 (20130101) C12N 9/1205 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class Enzymes C12Y 204/01122 (20130101) C12Y 207/0106 (20130101) C12Y 501/03002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160003 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Shoujun Xu (Houston, Texas); Qiongzheng Hu (Houston, Texas); Yuhong Wang (Housjton, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices. |
| FILED | Monday, June 11, 2018 |
| APPL NO | 16/620571 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 7/52 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160073 | WEI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei David WEI (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides for a composition that includes a modified M/TiO2 composite, method of making the modified M/TiO2 composite, an electrode having modified M/TiO2 composite surface and a photoelectrochemical cell including the electrode, and methods of photoelectrochemical oxidation of water. The modified M/TiO2 composite can be used in an electrode configuration, for example, in a photoelectrochemical cell for the photoelectrochemical oxidation of water. The present disclosure provides for a modified M/TiO2 composite that has a catechol compound(s) (e.g., oligo-catechol) adsorbed onto at least the M (metal) on the surface of the modified M/TiO2 composite. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/917150 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) Original (OR) Class C25B 1/55 (20210101) C25B 5/00 (20130101) C25B 11/081 (20210101) C25B 11/085 (20210101) C25B 11/087 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160685 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Genda CHEN (Rolla, Missouri); Jie GAO (Rolla, Missouri); Chuanrui GUO (Rolla, Missouri) |
| ABSTRACT | A miniature, micrometer-accuracy, three-dimensional (3D) position-to-optical displacement sensor that has at least one extrinsic Fabry-Perot interferometer (EFPI) in Z direction and a series of plasmonic metasurface resonators with distinctive wavelength-selective characteristics in X and Y directions. The interferometer comprises at least one single mode optic fiber for light propagation, and a substrate mirror to create a light interference fringe as a function of distance between the mirror and the distal end of the optic fiber. Each plasmonic resonator is capable of modifying the substrate mirror and comprises an array of multiple unit nanostructure unit cells that are arranged in a two-dimensional (2D) square lattice or array in the X-Y plane. The nanostructure unit cells are preferably inscribed in the top layer of a three-layer thin film via the focused ion beam (FIB). |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/919158 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02058 (20130101) Original (OR) Class G01B 2290/25 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160802 | Schultz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William W. Schultz (Ann Arbor, Michigan); Subramaniam Balakrishna (Ann Arbor, Michigan) |
| ABSTRACT | Methods and systems for characterizing multiple parameters of viscous fluid simultaneously are provided. By imposing an oscillatory deformation profile on a filament formed of the viscous fluid between two plates, a nonlinear fit to the deformation profile captured at different times is analyzed against a filament model dependent upon the plates radius, viscous fluid density, and the oscillation frequency of the imposed deformation profile. The Reynolds number, Weber number, and the aspect ratio of the viscous fluid are thus determined, for identifying the Newtonian fluid. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991502 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/165 (20130101) Original (OR) Class G01N 33/487 (20130101) G01N 2203/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160817 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongming Li (Notre Dame, Indiana); Gregory Hartland (Granger, Indiana); Masaru Ken Kuno (Notre Dame, Indiana) |
| ABSTRACT | Mid-infrared photothermal heterodyne imaging (MIR-PHI) techniques described herein overcome the diffraction limit of traditional MIR imaging and uses visible photodiodes as detectors. MIR-PHI experiments are shown that achieve high sensitivity, sub-diffraction limit spatial resolution, and high acquisition speed. Sensitive, affordable, and widely applicable, photothermal imaging techniques described herein can serve as a useful imaging tool for biological systems and other submicron-scale applications. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/149245 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/35 (20130101) G01N 21/171 (20130101) G01N 21/3563 (20130101) Original (OR) Class G01N 2021/1712 (20130101) G01N 2021/1714 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/02 (20130101) G01Q 60/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160866 | Mavrikakis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emmanouil Mavrikakis (Middleton, Wisconsin); Jake Gold (Houston, Texas); Trenton Wolter (North St. Paul, Minnesota); Nicholas Abbott (Lansing, New York); Nanqi Bao (Ithaca, New York); Huaizhe Yu (Ithaca, New York); Ayushi Tripathi (Ithaca, New York) |
| ABSTRACT | Methods for monitoring catalytic chemical reactions are provided. Such a method may comprise (a) exposing a solid surface to conditions to induce a chemical reaction of reactants at an interface formed between the solid surface and a liquid crystal, wherein the solid surface catalyzes the chemical reaction and the liquid crystal is characterized by an anchoring orientation that changes during the chemical reaction; and (b) measuring the anchoring orientation of the liquid crystal at one or more time points and at one or more locations on the solid surface during step (a). Systems for carrying out the methods are also provided. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/530692 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0006 (20130101) B01J 19/24 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/12 (20130101) C09K 2019/0437 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 31/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160903 | Wolf et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Wolf (Arlington, Virginia); Fathima Yushra Thanzeel (Washington, District of Columbia) |
| ABSTRACT | The present invention relates to compositions and methods for determining the absolute configuration of D/L-cysteine and/or the enantiomeric composition of cysteine and/or the concentration of total cysteine in a sample. Uses of the composition and method are also described. |
| FILED | Saturday, November 26, 2022 |
| APPL NO | 17/994322 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 309/65 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/33 (20130101) G01N 21/64 (20130101) G01N 33/52 (20130101) G01N 33/6815 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161678 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tongping Liu (Boston, Massachusetts); Jin Zhou (Boston, Massachusetts); Jiaxun Tang (Boston, Massachusetts); Hanmei Yang (Boston, Massachusetts) |
| ABSTRACT | Various examples are provided related to cache miss classification. In one example, a method for classification of cache misses includes detecting a susceptible instruction of a program with frequent cache misses based upon performance monitoring units (PMU) based course grain sampling; collecting a memory access pattern of the susceptible instruction using breakpoint-based fine-grain sampling; and classifying a type of cache miss associated with the susceptible instruction. The type of cache miss can be classified as a capacity miss, a conflict miss, or a coherence miss using the memory access pattern of the susceptible instruction. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992119 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/3037 (20130101) Original (OR) Class G06F 11/3072 (20130101) G06F 11/3409 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161769 | Rejaie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Oregon (Eugene, Oregon); Niksun Inc (PRINCETON, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reza Rejaie (Eugene, Oregon); Ramakrishnan Durairajan (Eugene, Oregon); Christopher H. MISA (Eugene, Oregon); Walter Willingger (Madison, New Jersey) |
| ABSTRACT | A method for network dataplane telemetry includes: a) receiving telemetry queries, where each query includes a requested network telemetry task, and associated query result accuracy and query result latency weights; b) every epoch, scheduling the telemetry queries to produce a schedule associating to each sub-epoch of an epoch for a subset of the telemetry queries; c) every sub-epoch, reprogramming a programmable dataplane device to execute scheduled telemetry queries associated the sub-epoch; d) every sub-epoch, collecting and aggregating intermediate query results from the programmable dataplane device; e) every epoch, returning aggregated results of completed queries; wherein scheduling the telemetry queries uses a multi-objective optimization that uses multiple objective functions weighted by the query result accuracy and query result latency weights to balance resource requirements of the runtime programmable network switch, query result accuracy, and query result latency. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/097147 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4881 (20130101) G06F 16/2462 (20190101) G06F 16/24556 (20190101) Original (OR) Class G06F 16/24578 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 43/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163461 | Afzal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Hamidreza Afzal (Davis, California); Omeed Momeni (Davis, California); Rouzbeh Kananizadeh (Folsom, California); Razieh Abedi (Irvine, California); Payam Heydari (Irvine, California) |
| ABSTRACT | Techniques, systems and architectures for generating desired phase shifts in a phased array to control the directions of radiation in a wide range of angles are disclosed. Particularly, phased array architectures based on novel PLL-coupled phase shifting techniques for implementation in millimeter-wave (mm-wave) and sub-terahertz (sub-THz) operations range are described. In one aspect, a phased array including an array of unit cells is disclosed. In some embodiments, each unit cell in the array of unit cells includes a dual-nested PLL that is configured to effectuate phase locking and frequency locking to a reference signal from an adjacent unit cell. Moreover, each PLL includes control circuitry that can generate a wide range of phase shifts between adjacent unit cells to facilitate phased-array operations. Note that using the dual-nested PLL to generate a desired phase shift between adjacent radiating elements eliminates the use of conventional lossy phase shifters in the phased array. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/151697 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/36 (20130101) Original (OR) Class Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/0802 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163830 | POLESE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michele POLESE (Boston, Massachusetts); Francesco RESTUCCIA (Boston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts) |
| ABSTRACT | A system and method for beam management in a wireless network are provided. A learning module having a trained classification module processes received I/Q input samples to determine transmitted beam information of incoming RF transmissions. The learning module includes a beam inference engine to determine waveforms waveform characteristics of incoming RF transmissions beams, and an angle of arrival engine operative to determine an angle of arrival of the incoming RF transmissions beams on an antenna array. An incoming RF transmission beam and angle of arrival are selected based on the determined waveforms for beam management operations. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/093602 |
| CURRENT CPC | Transmission H04B 7/086 (20130101) Original (OR) Class H04B 7/088 (20130101) H04B 7/0695 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230158520 | Fedorov |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrei G. Fedorov (Atlanta, Georgia) |
| ABSTRACT | Embodiments of the present disclosure provide for methods and systems for making structures using an electrospray system while under vacuum. In particular, embodiments of the present disclosure provide for methods and systems for ultra-fast growth of high aspect ratio nano/meso/micro-structures with three dimensional topological complexity and control of phase and composition of the structure formed. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/158666 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/16 (20130101) Original (OR) Class B05B 5/035 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/04 (20130101) B05D 3/068 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/145 (20190501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158712 | Rodgers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. Rodgers (Bloomfield Twp., Michigan); Terrence Wathen (Sterling Heights, Michigan); Selina Xinyue Zhao (Rochester Hills, Michigan); Venkateshwar R. Aitharaju (Troy, Michigan) |
| ABSTRACT | The present application discloses a method of making a preform for use in manufacturing a component made of a composite material. The method includes stitching fibers onto a film to form a fiber bed in a two-dimensional shape, removing the film from the fiber bed, and adjusting the fiber bed into a three-dimensional shape to form the preform. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531318 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 11/16 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158752 | Cook et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam W. Cook (Albuquerque, New Mexico); Mathias C. Celina (Albuquerque, New Mexico); Carl Erik Linde (Albuquerque, New Mexico); Leah N. Appelhans (Tijeras, New Mexico); Devin J. Roach (Albuquerque, New Mexico) |
| ABSTRACT | Direct ink write (DIW) printing of reactive resins presents a unique challenge due to the time-dependent nature of the rheological and chemical properties of the ink. As a result, careful print optimization or process control is important to obtain consistent, high quality prints. The present invention uses a flow-through characterization cell for in situ chemical monitoring of a resin ink during DIW printing. Additionally, in-line extrusion force monitoring can be combined with off-line post inspection using machine vision. By combining in-line spectroscopy and force monitoring, it is possible to follow reaction kinetics (for example, curing of a reactive resin) and viscosity changes during printing, which can be used for a closed-loop process control. Additionally, the capability of machine vision to automatically identify and quantify print artifacts can be incorporated on the printing line to enable real-time, AI-assisted quality control of the printed products. Together, these techniques can form the building blocks of an optimized process control strategy when complex reactive ink must be used to produce printed hardware. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 17/967083 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/264 (20170801) B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158789 | Selter |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Thomas Matthew Selter (Blue Springs, Missouri) |
| ABSTRACT | A fixture for lap shear bonding a bottom panel to a top panel comprises a bottom tool, a first spacer, a second spacer, and a top tool. The bottom tool has a quadrilateral shape including a top surface, a bottom surface, and four side surfaces and is configured to retain the bottom panel on the top surface. The first spacer is attached to the top surface of the bottom tool adjacent to one edge. The second spacer is attached to the top surface of the bottom tool adjacent to an opposing edge. The top tool has a quadrilateral shape including a top surface, a bottom surface, and four side surfaces and is configured to retain the top panel on the bottom surface. The top tool is further configured to attach to the first spacer and the second spacer such that the top panel contacts the bottom panel. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533962 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 38/1833 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159340 | KAMYSBAYEV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | VLADISLAV KAMYSBAYEV (Chicago, Illinois); Dmitri V. Talapin (La Grange Park, Illinois) |
| ABSTRACT | Methods for modifying the surface termination of two-dimensional (2D) transition metal carbides (MXenes) are provided. The methods, which allow for versatile chemical modification of the terminating anions via halide exchange or substitution and elimination reactions in molten inorganic salts, provide a processing approach that is widely applicable to MXenes as a broad class of functional materials. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/922848 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/914 (20170801) C01B 32/921 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/20 (20130101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159346 | Sant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav N. Sant (Los Angeles, California); Laurent G. Pilon (Los Angeles, California); Erika Blanca Callagon La Plante (Los Angeles, California); Bu Wang (Los Angeles, California); Zongsu Wei (Los Angeles, California); Sara Vallejo Castaño (Los Angeles, California) |
| ABSTRACT | Divalent ions are extracted from solids by leaching to form a divalent ion-containing solution. The divalent ion-containing solution is subjected to concentration to form a concentrated divalent ion-containing solution. Precipitation of a divalent ion hydroxide salt is induced from the concentrated divalent ion-containing solution. In other cases, the concentrated divalent ion-containing solution is exposed to carbon dioxide to induce precipitation of a divalent ion carbonate salt. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100283 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 5/22 (20130101) C01F 5/24 (20130101) C01F 5/145 (20130101) C01F 11/005 (20130101) C01F 11/16 (20130101) C01F 11/181 (20130101) Original (OR) Class C01F 11/185 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/66 (20130101) C02F 1/441 (20130101) C02F 1/442 (20130101) C02F 1/4691 (20130101) C02F 1/5236 (20130101) C02F 9/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159722 | Kratish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yosi Kratish (Evanston, Illinois); Tobin J. Marks (Evanston, Illinois) |
| ABSTRACT | Provided are methods for depolymerizing polyesters, e.g., PET, PBT, and PEN. In embodiments, a method for depolymerizing a polyester comprises combining a polyester comprising a plurality of ester linking groups (R′C(O)OR), a metal triflate catalyst, and a hydrogenation catalyst, under conditions to cleave a C—O bond in an alkoxy group (OR) of an ester linking group of the plurality of ester linking groups. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/972166 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/16 (20130101) Original (OR) Class C08J 2367/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160043 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa); National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Iver E. Anderson (Ames, Iowa); Emma Marie Hamilton White (Des Moines, Iowa); Duane Johnson (Ames, Iowa); Nicolas Argibay (Ames, Iowa); Andrew B. Kustas (Elizabeth, Colorado); Michael Chandross (Albuquerque, New Mexico); Raymond V. Puckett (Albuquerque, New Mexico) |
| ABSTRACT | Refractory-reinforced multiphase high entropy alloys (RHEAs) advantageously providing high strength and fracture toughness in an as-AM deposited condition and other conditions are described. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/803779 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/082 (20130101) B22F 2301/052 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Alloys C22C 30/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160608 | Ho |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clifford K. Ho (Albuquerque, New Mexico) |
| ABSTRACT | Systems and methods for falling particle receivers are disclosed that include shield or deflector structures around the receiver aperture to reduce wind effects and/or heat losses from the falling particles. External and internal structures are disclosed that can be tailored to reduce particle, thermal, and radiative losses from within the cavity receiver due to external wind and the falling particles that are irradiated within the receiver. Structures of varying shapes, sizes, and composition (transparent, reflective) are described. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/094652 |
| CURRENT CPC | Solar Heat Collectors; Solar Heat Systems F24S 20/20 (20180501) F24S 40/10 (20180501) Original (OR) Class F24S 80/20 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160707 | KIBALAMA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DELPHI TECHNOLOGIES IP LIMITED (Belleville, Barbados); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis KIBALAMA (Columbus, Ohio); Shreshta RAJAKUMAR DESHPANDE (Columbus, Ohio); Shobhit GUPTA (Columbus, Ohio); Nicola PIVARO (Adria, Italy); Marcello CANOVA (Columbus, Ohio); Karim AGGOUNE (Auburn Hills, Michigan); Peter M. OLIN (Ann Arbor, Michigan) |
| ABSTRACT | A method for controlling vehicle propulsion includes receiving signal data corresponding to a signaled intersection of a route being traversed by a vehicle. The method further includes determining an intersection propulsion profile for the signaled intersection based on at least a current vehicle speed and the signal data. The method further includes determining, based on the intersection propulsion profile, whether to deviate from a vehicle energy consumption profile corresponding to the route being traversed by the vehicle. The method further includes, in response to a determination to deviate from the vehicle energy consumption profile, selectively controlling vehicle propulsion of the vehicle according to the intersection propulsion profile. The method further includes, in response to traversing the intersection, selectively controlling vehicle propulsion according to the vehicle energy consumption profile. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/534621 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 58/30 (20190201) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 20/20 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3469 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161117 | Neidigk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Neidigk (Albuquerque, New Mexico); Thomas M. Rice (Albuquerque, New Mexico) |
| ABSTRACT | A system or method for a magnetic self-aligning coupling device for a fiber optic cable. The device includes a first end coupling comprising a first magnet and a second magnet. Both magnets include a mating surface and an annular ring defining an axial aperture. The aperture receives a distal end of a segment of fiber optic cable in a tight fit. The fiber optic cable has an exterior sleeve and a fiber core. The fiber core of the first segment and the second segment of the fiber optic cable are axially aligned by magnetic force in the first and second apertures to create a continuous fiber optic path. A method for detecting a security breach of a door using the self-aligning couplings is also described. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/104693 |
| CURRENT CPC | Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 8/16 (20130101) Optical Elements, Systems, or Apparatus G02B 6/354 (20130101) G02B 6/3572 (20130101) G02B 6/3886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161220 | Pooser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raphael C. Pooser (Oak Ridge, Tennessee); Benjamin J. Lawrie (Oak Ridge, Tennessee); Petro Maksymovych (Oak Ridge, Tennessee) |
| ABSTRACT | A truncated non-linear interferometer-based sensor system includes an input port that receives an optical beam and a non-linear amplifier that amplifies the optical beam with a pump beam and renders a probe beam and a conjugate beam. The system’s local oscillators have a relationship with the respective beams. The system includes a sensor that transduces an input with the probe beam and the conjugate beam or their respective local oscillators. It includes one or more phase-sensitive detectors that detect a phase modulation between the respective local oscillators and the probe beam and the conjugate beam. Output from the phase-sensitive-detectors is based on the detected phase modulation. The phase-sensor-detectors include measurement circuitry that measure the phase signals. The measurement is the sum or difference of the phase signals in which the measured combination exhibit a quantum noise reduction in an intensity difference or a phase sum or an amplitude difference quadrature. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100157 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 35/00 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02 (20130101) G01B 9/02003 (20130101) G01B 9/02079 (20130101) G01B 9/02081 (20130101) G01B 2290/55 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 20/02 (20130101) G01Q 60/24 (20130101) G01Q 60/38 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/29 (20130101) G02F 1/3538 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/10076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162116 | Halsema et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John A. Halsema (Vienna, Virginia); Christopher A. Guryan (Vienna, Virginia); Steven Prescott (Vienna, Virginia); Ben Russell (Vienna, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Halsema (Vienna, Virginia); Christopher A. Guryan (Vienna, Virginia); Steven Prescott (Vienna, Virginia); Ben Russell (Vienna, Virginia) |
| ABSTRACT | A method of integrating a probabilistic risk assessment (“PRA”) tool and a security risk assessment (“SRA”) tool, said method comprising creating at least one simulation by the SRA tool; communicating the at least one simulation to the PRA tool; continuing the at least one simulation for a period of time; and monitoring, by the PRA tool, a site's condition. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/866843 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0635 (20130101) Original (OR) Class G06Q 10/06375 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162875 | Snuggerud |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NuScale Power, LLC (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross Douglas Snuggerud (Corvallis, Kansas) |
| ABSTRACT | A damping area or “dash pot” on the upper ends of control rods absorb energy from dropped control rod assemblies without narrowing the diameter of guide tubes. As a result, coolant can freely flow through the guide tubes reducing boiling water issues. The dampening area reduces a separation distance between an outside surface of the control rod and an inside surface of the guide tubes decelerating the control rods when entering a top end of the guide tubes. In another example, the dampening area may be located on a drive shaft. The dampening area may have a larger diameter than an opening in a drive shaft support member that decelerates the drive shaft when dropped by a drive mechanism. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/104764 |
| CURRENT CPC | Nuclear Reactors G21C 3/322 (20130101) G21C 3/3315 (20130101) G21C 7/11 (20130101) G21C 7/20 (20130101) Original (OR) Class G21C 7/117 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162879 | Liszkai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NuScale Power, LLC (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tamas R. Liszkai (Corvallis, Oregon); Todd Sorensen (St Joseph, Michigan) |
| ABSTRACT | Steam generator systems including tubesheet assemblies, such as for use in nuclear reactor systems, and associated devices and methods are described herein. A representative steam generator system can be installed in a nuclear reactor vessel positioned to house a primary coolant. The steam generator system can include a tubesheet assembly defining a plenum and comprising a tubesheet and a flexible connection portion coupling the tubesheet to the reactor vessel. The tubesheet can include a plurality of perforations fluidly coupled to the plenum. The steam generator system can further comprise a plurality of heat transfer tubes fluidly coupled to the perforations and configured to receive a flow of a secondary coolant. The connection portion can be more flexible than the tubesheet and the reactor vessel to reduce stresses on the tubesheet and the connections (e.g., tube-to-tubesheet (TTS) welds) between the tubes and the tubesheet during operation of the nuclear reactor system. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991837 |
| CURRENT CPC | Methods of Steam Generation; Steam Boilers F22B 37/002 (20130101) Nuclear Power Plant G21D 5/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163286 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies, Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Eugene Michael BERDICHEVSKY (Alameda, California); Alexander Thomas JACOBS (Atlanta, Georgia); Alper NESE (Alameda, California); Damian HARRIS (San Francisco, California); Bogdan ZDYRKO (Atlanta, Georgia) |
| ABSTRACT | Battery electrode compositions and methods of fabrication are provided that utilize composite particles. Each of the composite particles may comprise, for example, a high-capacity active material and a porous, electrically-conductive scaffolding matrix material. The active material may store and release ions during battery operation, and may exhibit (i) a specific capacity of at least 220 mAh/g as a cathode active material or (ii) a specific capacity of at least 400 mAh/g as an anode active material. The active material may be disposed in the pores of the scaffolding matrix material. According to various designs, each composite particle may exhibit at least one material property that changes from the center to the perimeter of the scaffolding matrix material. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154368 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/362 (20130101) H01M 4/386 (20130101) H01M 4/388 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163315 | Park et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jae Hyung Park (Bolingbrook, Illinois); Deborah J. Myers (Lisle, Illinois) |
| ABSTRACT | Systems for creating electrodes for polymer electrolyte membrane fuel cells include an XY stage having a heated vacuum table physically coupled to the XY stage. The vacuum table has a working face with a plurality of channels formed therein to communicate vacuum pressure from a port coupled to a vacuum source to the channels. A sheet of perforated heat-conductive material has staggered holes configured to evenly distribute the vacuum pressure from the channels through the perforated sheet. A heat-conductive wire mesh is placed over the perforated sheet, and has openings smaller than the staggered holes such that a membrane material placed on the wire mesh is not deformed by the vacuum pressure. A nanopipette or micropipette coupled to a pump is configured to deposit electrode ink onto an exposed surface of the membrane material as the controller device causes the XY stage to move the vacuum table to control deposition of the electrode ink onto the surface of the membrane material. |
| FILED | Thursday, January 12, 2023 |
| APPL NO | 18/096051 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/02 (20130101) Apparatus for Applying Fluent Materials to Surfaces, in General B05C 11/1013 (20130101) B05C 11/1034 (20130101) B05C 13/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/881 (20130101) H01M 4/8828 (20130101) Original (OR) Class H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163346 | KUMTA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | PRASHANT N. KUMTA (PITTSBURGH, Pennsylvania); PARTHA SAHA (PITTSBURGH, Pennsylvania); MONI KANCHAN DATTA (PITTSBURGH, Pennsylvania); AYYAKKANNU MANIVANNAN (MORGANTOWN, West Virginia) |
| ABSTRACT | The invention relates to Chevrel-phase materials and methods of preparing these materials utilizing a precursor approach. The Chevrel-phase materials are useful in assembling electrodes, e.g., cathodes, for use in electrochemical cells, such as rechargeable batteries. The Chevrel-phase materials have a general formula of Mo6Z8 (Z=sulfur) or Mo6Z18-yZ2y (Z1=sulfur; Z2=selenium), and partially cuprated Cu1Mo6S8 as well as partially de-cuprated Cu1-xMgxMo6S8 and the precursors have a general formula of MxMo6Z8 or MxMo6Z18-yZ2y, M=Cu. The cathode containing the Chevrel-phase material in accordance with the invention can be combined with a magnesium-containing anode and an electrolyte. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/100722 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 19/002 (20130101) C01B 19/007 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/006 (20130101) C01G 39/06 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/581 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 10/054 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163587 | Lu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Fei Lu (Wynnewood, Pennsylvania); Hua Zhang (Philadelphia, Pennsylvania); Reza Kheirollahi (Philadelphia, Pennsylvania) |
| ABSTRACT | There may be two active snubbers for direct current (dc) solid-state circuit breakers (SSCBs): metal-oxide-varistor with resistor-capacitor-switch (MOV-RCS) and active-MOV with resistor-capacitor-diode (AMOV-RCD). In the snubber branch, either half- or full-controlled switch can be used, leading to four topologies. The improved snubbers offer several improvements: 1) MOV is disconnected from the power line during SSCB OFF-state, which enhances reliability as neither voltage nor power appears on MOV; 2) voltage utilization rate ηv of the main switch is remarkably increased, which improves efficiency and power density, and reduces design cost shows experiments of five prototypes are conducted including four proposed snubbers and a comparison with conventional MOV-RCD snubber. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 18/058447 |
| CURRENT CPC | Resistors H01C 7/108 (20130101) Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 9/16 (20130101) H01H 9/542 (20130101) H01H 2009/543 (20130101) Emergency Protective Circuit Arrangements H02H 3/087 (20130101) Original (OR) Class Pulse Technique H03K 17/687 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163682 | Shah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suyash Sushilkumar Shah (Raleigh, North Carolina); Subhashish Bhattacharya (Raleigh, North Carolina); Sagar Kumar Rastogi (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to parallel-connected resonant converters and their operation. In one example, a system includes a plurality of resonant converters connected in parallel and an output voltage regulator that can generate a common control reference signal provided to each of the plurality of resonant converters. The common control reference signal can be based upon a signal from a single output voltage sensor, where operation of the resonant converters is controlled in response to the common control reference signal. In another example, a method includes monitoring an output voltage of a plurality of resonant converters connected in parallel using a single output voltage sensor; generating a common control reference signal using a signal from the single output voltage sensor; and providing the common control reference signal to each of the resonant converters, where operation of the resonant converters is controlled in response to the common control reference signal. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992476 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/0009 (20210501) H02M 3/01 (20210501) Original (OR) Class H02M 3/06 (20130101) H02M 3/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230163850 | Buckley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon Walter Buckley (Walnut Creek, California); David Simon Perlmutter (Oakland, California); Peter Thomas Setsuda DeVore (Livermore, California); Apurva Shantharaj Gowda (Mountain View, California); Jason Thomas Chou (Walnut Creek, California) |
| ABSTRACT | Devices, systems and methods for encoding information using optical components are described. An example photonic filtered sampler includes a spectral shaper configured to receive an optical pulse train, a dispersive element positioned to receive an output of the spectral shaper and to expand spectral contents thereof in time, and a modulator configured to receive an output of the dispersive element and a radio frequency (RF) signal, and to produce a modulated output optical signal in accordance with the RF signal. In this configuration, one or more characteristics of the modulated output optical signal is determined based on a spectral shape provided by the spectral shaper and dispersive properties of the dispersive element. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/159054 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/21 (20130101) G02F 1/212 (20210101) G02F 1/365 (20130101) G02F 2/004 (20130101) G02F 2/006 (20210101) Transmission H04B 10/2557 (20130101) Original (OR) Class Multiplex Communication H04J 14/0221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230164904 | Romanenko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FERMI RESEARCH ALLIANCE, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Romanenko (Batavia, Illinois); Sam Posen (Arlington Heights, Illinois); Anna Grassellino (Batavia, Illinois) |
| ABSTRACT | A system and method for treating a cavity comprises preparing a superconducting radio frequency (SRF) cavity for removal of a dielectric layer from on an inner surface of the SRF cavity, subjecting the SRF cavity to a heat treatment in order to remove the dielectric layer from the inner surface of the SRF cavity, and preventing the development of a new dielectric layer on the inner surface of the SRF cavity by preventing an interaction between the inner surface of the SRF cavity and atmospheric gasses. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/898065 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/06 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/20 (20130101) Original (OR) Class Electric solid-state devices not otherwise provided for H10N 60/01 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230157586 | Dorin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); The Florida International University Board of Trustees (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard I. Dorin (Albuquerque, New Mexico); Clifford R. Qualls (Mesa, Arizona); Frank K. Urban (Palmetto Bay, Florida) |
| ABSTRACT | Methods, systems, and apparatuses for modeling and determining of the cortisol elimination rate in patients are described. One or more physiological measurements associated with a patient may be determined and applied to a multi-compartment model. One or more physiological parameters, including the cortisol elimination rate, may be determined based on applying the one or more physiological measurements to the multi-compartment model. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993282 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/145 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230157851 | Hansen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); Fraunhofer-Gesellschaft zur Foerderung de Angewandten Forschung e. V. (München, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Hansen (Minneapolis, Minnesota); Sara Koehler-Mcnicholas (Minneapolis, Minnesota); Eric Nickel (Minneapolis, Minnesota); Kyle Barrons (Minneapolis, Minnesota); Felix Starker (München, Germany); Spencer Mion (Minneapolis, Minnesota); John Ferguson (Minneapolis, Minnesota); Stuart Fairhurst (Minneapolis, Minnesota); Ellankavl Ramasamy (München, Germany); Karl Koester (Minneapolis, Minnesota); Urs Schneider (München, Germany) |
| ABSTRACT | Breathable residual-limb system that admits air and allows sweat to evaporate from the surface of the residual limb. In an embodiment, the system comprises a liner sock to be worn on the residual limb, and comprising air-permeable textile forming a substantially cylindrical portion that is closed on a distal end and open on a proximal end and comprising an internal surface and an external surface. The liner sock further comprises a friction-interface material that covers only a portion of the internal surface of the air-permeable textile, such that, when worn on the residual limb, the friction-interface material contacts a surface of the residual limb, and an uncovered portion of the air-permeable textile which the friction-interface material does not cover allows air to pass between an external environment of the liner sock and the surface of the residual limb. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993303 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/80 (20130101) A61F 2/5044 (20130101) A61F 2/7812 (20130101) Original (OR) Class A61F 2002/785 (20130101) A61F 2002/5055 (20130101) A61F 2002/7818 (20130101) A61F 2013/00136 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230158293 | Bogie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Govemment as Represented by the Department of Veterans Affairs (Washington, District of Columbia); CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kath M. Bogie (Cleveland, Ohio); DHRUV SESHADRI (Cleveland, Ohio); MEDHA SRIGIRI (Cleveland, Ohio); CHRISTIAN A. ZORMAN (Euclid, Ohio) |
| ABSTRACT | An electrode can comprise carbon black and one of polydimethylsiloxane (PDMS) or PVA, wherein the carbon black has a weight of between 10% and 50% of a weight of the PDMS or PVA. The electrode can be suitable for bioelectronics. A pattern of hydrogel can be deposited on the electrode for providing adhesion to a subject. The electrode can be used in wound treatment and/or monitoring devices or in various other bioelectronics applications. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/917452 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0531 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/00068 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0468 (20130101) Original (OR) Class Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159542 | Nabors et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama); SOUTHERN RESEARCH INSTITUTE (Birmingham, Alabama); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama); SOUTHERN RESEARCH INSTITUTE (Birmingham, Alabama); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | Louis B. Nabors (Birmingham, Alabama); Natalia Filippova (Birmingham, Alabama); Xiuhua Yang (Birmingham, Alabama); Subramaniam Ananthan (Birmingham, Alabama); Vibha Pathak (Birmingham, Alabama); Peter King (Birmingham, Alabama) |
| ABSTRACT | This disclosure provides compounds that inhibit RNA-binding proteins, such as Human antigen R protein (HuR). The compounds described herein have a high affinity for HuR multimers and inhibit the pathological processes that promote cancer and inflammation. The compounds are highly water-soluble and have good biodistribution for both systemic and central nervous system disease processes. The compounds provide a unique therapeutic option for disease processes related to neoplastic progression or acute or chronic inflammation. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/996886 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 29/00 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159758 | HELGASON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VitroLabs Inc (Milpitas, California); King's College London (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ingvar HELGASON (South San Francisco, California); Dusko ILIC (London, United Kingdom) |
| ABSTRACT | Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/092816 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 89/06 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0625 (20130101) C12N 5/0629 (20130101) C12N 5/0698 (20130101) C12N 11/02 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2502/13 (20130101) C12N 2502/091 (20130101) C12N 2502/094 (20130101) C12N 2506/45 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) Chemical Treatment of Hides, Skins or Leather, e.g Tanning, Impregnating, Finishing; Apparatus Therefor; Compositions for Tanning C14C 3/02 (20130101) C14C 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230158138 | Talaat et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adel Talaat (Madison, Wisconsin); Shaswath Chandrasekar (Madison, Wisconsin) |
| ABSTRACT | The present invention provides both QuilA-loaded chitosan (QAC)-encapsulated NA vaccine compositions and viral vaccine compositions that encode an Infectious Bronchitis Virus (IBV) spike (S) protein, an IBV nucleocapsid (N) protein, or both the S protein and the N protein. Additionally, the present invention provides methods in which the disclosed vaccines are administered to a subject to induce an immune response against IBV or to vaccinate the subject against IBV. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 18/058513 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/55577 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) C12N 2770/20043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230159596 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Holland Cheng (Oakland, California); Chun Chieh Chen (Oakland, California); Mohammad Ali Baikoghli (Oakland, California); Marie Stark (Oakland, California) |
| ABSTRACT | A Hepatitis E virus (HEV)-based virus like nanoparticle (HEVNP) made with a modified capsid protein containing at least a portion of open reading frame 2 (ORF2) protein conjugated with gold nanocluster is provided. Also provided are methods of targeted delivery of a nucleic acid using the HEVNP. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/935682 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/62 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230160256 | Isaacs |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mark Isaacs (Bay St. Louis, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Isaacs (Bay St. Louis, Mississippi) |
| ABSTRACT | A window glazing assembly that can convert an existing or already-installed window, or be used to assemble new construction windows as a multi-pane or multi-glazed window unit, is provided herein. In particular, the glazing assembly includes an attachment assembly (e.g., peel-and-stick double-sided adhesive tape) and one or more glazing layers. Some embodiments further include a spacer assembly comprising a plurality of spacer bars that may be individually installed, e.g., one by one, around the perimeter of the window such as, to the window sash, window frame, or glass window pane, itself. The glazing layer(s) can then be secured or adhered to the spacer assembly, for example, around the perimeter thereof. Some embodiments may include additional or intermediate glazing layers, providing additional insulating airspaces and enhanced performance. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849135 |
| CURRENT CPC | Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 3/56 (20130101) E06B 3/6733 (20130101) E06B 3/66323 (20130101) E06B 3/66352 (20130101) E06B 3/66376 (20130101) E06B 9/02 (20130101) Original (OR) Class E06B 2009/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230160783 | Houston et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward F. Houston (Bristow, Virginia); Manfred Foxx-Gruensteidl (Amissville, Virginia) |
| ABSTRACT | A content management system for customizing and controlling data distribution is disclosed. Data items can be customized and dispersed to disparate reception terminals according to various control mechanisms where they can convey relevant information to local or remote stakeholders. Data items can be integrated into existing data distribution structures in real time according to applicable control mechanisms and distribution protocols. Data resources can be efficiently used in distributing data under predefined and configurable conditions. Control mechanisms and distribution protocols can be determined based on an interested user's recognized status within the system. Design of the distribution system allows for informed delivery of essential information in a controlled and automated fashion such that users can interact with the system in receiving or distributing current and relevant information across the distribution network for others to access. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 18/057180 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 99/00 (20130101) Original (OR) Class Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/182 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/63 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230161827 | Bonnell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clayton C. Bonnell (Fairfax, Virginia); Gary C. Reblin (Falls Church, Virginia) |
| ABSTRACT | A method and system for generating a location identifier using a location code and a grid coordinate. The location code corresponds to a defined geographical area, such as a postal code or an area code. A grid coordinate can be determined based on destination location information, such as an address, a GPS-determined position, or other reference to a specific physical location. The location identifier is combined with the location code to generate a location identifier, which can be encoded in a computer readable format and placed on items for use in a distribution network. The location identifier can be used to facilitate domestic or international distribution of items using a common format or addressing scheme. The domestic and foreign distribution networks read and interpret location identifiers in order to deliver items. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/158397 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/9537 (20190101) Original (OR) Class G06F 16/24578 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/083 (20130101) G06Q 10/08355 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 29/007 (20130101) G09B 29/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162132 | BRIGGMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chandra A. BRIGGMAN (Springfield, Virginia); Jane Elizabeth QUENK (Washington, District of Columbia); Timothy M. MORAN (National Harbor, Maryland); Kelley A. SULLIVAN (Alexandria, Virginia); Robert E. DIXON, JR. (Washington, District of Columbia) |
| ABSTRACT | A method, electronic device, and computer-readable storage medium. A request is received to display a calendar identifying incoming physical item deliveries regarding a user's delivery point. User-associated shipment information is accessed identifying at least one first item scheduled for physical delivery and at least one second item scheduled for electronic delivery, and includes a record of physical delivery items and electronic delivery items. A sender's address is automatically populated to a recipient's address book, when a notification is received regarding the physical delivery item being in transit. Tracking data associated with the at least one first item from an integrated mail database and an integrated mail processing equipment is acquired and includes at least an expected delivery date. A notification regarding the at least one first item is displayed within a portion of an interface representative of the expected delivery date on the calendar. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152559 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/10 (20130101) G06Q 10/083 (20130101) G06Q 10/0833 (20130101) Original (OR) Class G06Q 10/1093 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 51/42 (20220501) H04L 51/234 (20220501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230157926 | Oaks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Tristan Oaks (Arlington, Virginia); Wesley Russell (Washington, District of Columbia); Sadie Simons (Ware, Massachusetts); Breanna Wood (Milton, Florida); Michael Plumley (Groton, Connecticut); Ronald Adrezin (East Lyme, Connecticut) |
| ABSTRACT | A method for cardiopulmonary resuscitation (CPR) includes supplying an inflation gas at an operative pressure to an inflation actuated soft gripper device to change form from an undeployed state to a deployed grip state that accommodates and grips a human torso. The inflation actuated soft gripper device includes a first inflatable gripper arm having a first distal end and a second inflatable gripper arm having a second distal end. The first distal end and the second distal end approach one another from the undeployed state to the deployed grip state. The first and second distal ends are spaced apart from one another further in the undeployed state than in the deployed grip state. An actuator power and a CPR control signal are delivered to a CPR pressure application device to cyclically extend and retract a pressure applicator along an axis in alignment with a sternum of the human torso. |
| FILED | Thursday, January 12, 2023 |
| APPL NO | 18/096124 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 31/004 (20130101) A61H 31/006 (20130101) Original (OR) Class A61H 2201/0103 (20130101) A61H 2201/0107 (20130101) A61H 2201/149 (20130101) A61H 2201/0157 (20130101) A61H 2201/1215 (20130101) A61H 2201/1621 (20130101) A61H 2201/1647 (20130101) A61H 2201/1664 (20130101) A61H 2201/5015 (20130101) A61H 2201/5025 (20130101) A61H 2201/5043 (20130101) A61H 2201/5097 (20130101) A61H 2205/084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162206 | Ellison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Chang Ellison (Arlington, Virginia); Kelli L. Biegger (Fort Worth, Texas); Daniel A. Boyd (Arlington, Virginia); Brandon P. Gutierrez (Johns Creek, Georgia); Jason Lim (Alexandria, Virginia) |
| ABSTRACT | In an example, a subject using a user mobile-identification-credential device (UMD) requests vetting by a vetting system, which receives verified subject information associated with a level-n mobile identification credential (MIC-n) that UMD received from a level-n authorizing party system (APS-n). MIC-n is linked to lower level MIC-0 to MIC-(n-1). The vetting system, as level-n relying party system (RPS-n), uses the verified subject information associated with the linked MIC-0 to MIC-n to verify or not verify the identity of the subject, develops an identity profile of the subject, and determines a vetting result of the subject by calculating a composite trust score based on MIC trust values for the multiple levels of MIC. MIC-i (i = 1 to n) is linked to MIC-(i-1) which UMD received from APS-(i-1), and APS-i is RPS-(i-1) which verified the identity of the subject using verified subject information associated with MIC-(i-1), such that MIC-0 to MIC-n are linked. |
| FILED | Thursday, January 12, 2023 |
| APPL NO | 18/096366 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/018 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3213 (20130101) Wireless Communication Networks H04W 12/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230160256 | Isaacs |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mark Isaacs (Bay St. Louis, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Isaacs (Bay St. Louis, Mississippi) |
| ABSTRACT | A window glazing assembly that can convert an existing or already-installed window, or be used to assemble new construction windows as a multi-pane or multi-glazed window unit, is provided herein. In particular, the glazing assembly includes an attachment assembly (e.g., peel-and-stick double-sided adhesive tape) and one or more glazing layers. Some embodiments further include a spacer assembly comprising a plurality of spacer bars that may be individually installed, e.g., one by one, around the perimeter of the window such as, to the window sash, window frame, or glass window pane, itself. The glazing layer(s) can then be secured or adhered to the spacer assembly, for example, around the perimeter thereof. Some embodiments may include additional or intermediate glazing layers, providing additional insulating airspaces and enhanced performance. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849135 |
| CURRENT CPC | Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 3/56 (20130101) E06B 3/6733 (20130101) E06B 3/66323 (20130101) E06B 3/66352 (20130101) E06B 3/66376 (20130101) E06B 9/02 (20130101) Original (OR) Class E06B 2009/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230162614 | Bell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Future Engineers (Burbank, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deanne Bell (Burbank, California) |
| ABSTRACT | A system for managing innovation challenges includes a computing apparatus having a processor and a memory with computer readable program code, wherein the processor under control of the computer readable program code is configured to implement, a content management system that operates to automatically generate an innovation challenge for students based on a common template that includes student eligibility requirements, a user management system that operates to collect user information, obtains parental or guardian consent, and determines individual student eligibility for specific innovation challenges, a submission management system that operates to automate ingestion, display, storage, and judging of challenge entry submissions, and a dashboard display that operates to manage innovation challenge participation. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/094977 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06398 (20130101) G06Q 50/20 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/00 (20130101) G09B 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 20230162614 | Bell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Future Engineers (Burbank, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deanne Bell (Burbank, California) |
| ABSTRACT | A system for managing innovation challenges includes a computing apparatus having a processor and a memory with computer readable program code, wherein the processor under control of the computer readable program code is configured to implement, a content management system that operates to automatically generate an innovation challenge for students based on a common template that includes student eligibility requirements, a user management system that operates to collect user information, obtains parental or guardian consent, and determines individual student eligibility for specific innovation challenges, a submission management system that operates to automate ingestion, display, storage, and judging of challenge entry submissions, and a dashboard display that operates to manage innovation challenge participation. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/094977 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06398 (20130101) G06Q 50/20 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/00 (20130101) G09B 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20230162044 | Grgicak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); National University of Ireland Maynooth, Maynooth University (Maynooth, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Catherine M. Grgicak (New Brunswick, New Jersey); Desmond S. Lun (New Brunswick, New Jersey); Kenneth R. Duffy (Dublin, Ireland) |
| ABSTRACT | Systems and methods of the present disclosure enable automated analyses of a biological sample by receiving signal profiles of each allele of a set of cells in the sample. Cell vectors are generated by concatenating allele vectors derived from the signal profiles of each cell. A cluster model is utilized to generate clusters of the signal profiles based on the cell vectors to represent contributors. A first probability of observing the cluster given a target contributor donated their DNA and a second probability of observing the cluster given a random contributor donated are determined by comparing the target signal profile to each cluster. A likelihood ratio is determined from a ratio of the first and second probabilities, and the likelihood ratio is averaged across all clustered to output a probability of the target contributor having contributed to the sample. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/100727 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 40/20 (20190201) G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20230160685 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Genda CHEN (Rolla, Missouri); Jie GAO (Rolla, Missouri); Chuanrui GUO (Rolla, Missouri) |
| ABSTRACT | A miniature, micrometer-accuracy, three-dimensional (3D) position-to-optical displacement sensor that has at least one extrinsic Fabry-Perot interferometer (EFPI) in Z direction and a series of plasmonic metasurface resonators with distinctive wavelength-selective characteristics in X and Y directions. The interferometer comprises at least one single mode optic fiber for light propagation, and a substrate mirror to create a light interference fringe as a function of distance between the mirror and the distal end of the optic fiber. Each plasmonic resonator is capable of modifying the substrate mirror and comprises an array of multiple unit nanostructure unit cells that are arranged in a two-dimensional (2D) square lattice or array in the X-Y plane. The nanostructure unit cells are preferably inscribed in the top layer of a three-layer thin film via the focused ion beam (FIB). |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/919158 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02058 (20130101) Original (OR) Class G01B 2290/25 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20230159758 | HELGASON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VitroLabs Inc (Milpitas, California); King's College London (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ingvar HELGASON (South San Francisco, California); Dusko ILIC (London, United Kingdom) |
| ABSTRACT | Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/092816 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 89/06 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0625 (20130101) C12N 5/0629 (20130101) C12N 5/0698 (20130101) C12N 11/02 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2502/13 (20130101) C12N 2502/091 (20130101) C12N 2502/094 (20130101) C12N 2506/45 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) Chemical Treatment of Hides, Skins or Leather, e.g Tanning, Impregnating, Finishing; Apparatus Therefor; Compositions for Tanning C14C 3/02 (20130101) C14C 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20230162074 | DEBNATH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); IonQ, Inc. (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shantanu DEBNATH (College Park, Maryland); Norbert M. LINKE (Stevenson, Maryland); Christopher R. MONROE (Columbia, Maryland); Caroline FIGGATT (Denver, Colorado) |
| ABSTRACT | Aspects of the present disclosure describe techniques for controlling quantum states of ions in an ion chain for a quantum operation. For example, a method is described that includes providing, from a first direction, a global optical beam to the ions in the ion chain, and providing, from a second direction different from the first direction, to each ion in a subset of the ions in the ion chain, a respective addressing optical beam. The method further includes dynamically controlling each of the addressing optical beams being provided by using a respective channel in a multi-channel acousto-optic modulator (AOM) to implement, with the ion chain, one or more quantum gates in a sequence of quantum gates of the quantum operation. Aspects of a quantum information processing (QIP) system that includes the multi-channel AOM for performing the method are also described. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/969258 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/113 (20130101) G02F 1/116 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230162532 | Ratha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nalini K. Ratha (Yorktown Heights, New York); Sharathchandra Pankanti (Fairfield County, Connecticut); Lisa Marie Brown (Pleasantville, New York) |
| ABSTRACT | Generating visual data by defining a first action into a first set of objects and corresponding first set of motions, and defining a second action into a second set of objects and corresponding second set of motions. A relationship is then determined for the second action to the first action in terms of relationships between corresponding constituent objects and motions. Objects and motions are detected from visual data of first action. Visual data is composed for the second action from the data by transforming the constituent objects and motions detected in first action based on the corresponding determined relationships. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533770 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/7553 (20220101) G06V 40/23 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, May 25, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230525.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page