FedInvent™ Patent Applications
Application Details for Thursday, June 08, 2023
This page was updated on Monday, June 19, 2023 at 11:21 PM GMT
Department of Health and Human Services (HHS)
| US 20230172443 | Bec et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Julien Bec (Davis, California); Laura Marcu (Davis, California) |
| ABSTRACT | The system includes a catheter with an internal optical fiber that carries an optical beam and an optical element, which reflects the optical beam substantially orthogonal to a rotational axis of the catheter and is coupled to the end of the optical fiber. A motor drive unit (MDU) is coupled to the catheter, wherein the MDU comprises: a rotary collimator; a catheter interface, which couples the optical fiber to the rotary collimator; and a drive motor, which rotates the rotary collimator. The MDU also includes a first dichroic mirror that combines optical paths for a fluorescence-lifetime imaging (FLIm) system and an optical coherence tomography system into a single optical path, which is coupled to the optical fiber through the rotary collimator and the catheter interface. The MDU additionally includes a multispectral detector for the FLIm system, which is electrically coupled to a data acquisition unit forthe FLIm imagin system. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/923711 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/043 (20130101) Original (OR) Class A61B 5/066 (20130101) A61B 5/0084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172509 | Amir |
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| FUNDED BY |
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| APPLICANT(S) | SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nader Amir (San Diego, California) |
| ABSTRACT | Systems and methods for treating patients with an anxiety disorder are disclosed. The systems comprise a screen for displaying sets of stimuli, a computer to control the display of stimuli onto the screen during at least one treatment session and the ability for the patient to interact with the screen in response to the displayed stimuli. The interaction of the patient with the system during the treatment session is capable of treating patient anxiety associated with an anxiety disorder, such as social anxiety. Also provided are computer programs capable of being used in the systems and methods of the present invention for treating anxiety. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/105111 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/165 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 70/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172513 | Kuzum et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duygu Kuzum (La Jolla, California); Yichen Lu (Richmond, California); Xin Liu (San Diego, California); Jeong-hoon Kim (La Jolla, California) |
| ABSTRACT | Flexible, insertable, transparent microelectrode arrays that allow integration of electrophysiological recordings with any optical imaging or stimulation technology are disclosed. In some embodiments of the disclosed technology, a microelectrode array includes a flexible substrate layer including a shank member extending in a first direction and a tapered tip at an end of the shank member, and a plurality of electrode wires arranged in the first direction on the flexible substrate layer, wherein the plurality of electrode wires includes adjacent electrode wires having different lengths from each other such that an electrode wire arranged closer to a centerline of the flexible substrate layer is longer than an adjacent electrode arranged further away from the centerline of the flexible substrate. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/063040 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0084 (20130101) A61B 5/293 (20210101) Original (OR) Class A61B 2562/04 (20130101) A61B 2562/028 (20130101) A61B 2562/125 (20130101) A61B 2562/164 (20130101) A61B 2562/0209 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 1/008 (20130101) B81B 2201/12 (20130101) B81B 2203/04 (20130101) B81B 2203/0361 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172522 | Simeral et al. |
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| FUNDED BY |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Simeral (Greenwich, Rhode Island); Thomas Hosman (Providence, Rhode Island); Carlos Vargas-Irwin (Providence, Rhode Island); Daniel Thengone (Providence, Rhode Island); Leigh Hochberg (Providence, Rhode Island); Tyler Singer-Clark (Falmouth, Massachusetts) |
| ABSTRACT | Neural signals of a subject intending certain postures can be decoded and a controllable device can be commanded to perform certain actions based on the decoded intended postures with a system, and method of use thereof, including a brain machine interface (BMI) device. The system also includes electrodes in communication with the subject's nervous system to record the neural signals and the controllable device, both in communication with the BMI device. The BMI device can store instructions and previously calibrated neural activity patterns for the certain postures and a processor for receiving the neural signals, pre-processing the neural signals, decoding the neural signals into neural activity patterns, and matching the neural activity patterns to the previously calibrated neural activity patterns. If a match is determined, then the BMI device can send a command, previously linked to the intended posture, to the controllable device to perform the action. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075811 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/375 (20210101) Original (OR) Class A61B 5/384 (20210101) A61B 5/1116 (20130101) A61B 5/7267 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172525 | Hsieh et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julien Wen Hsieh (Geneva, Switzerland); Andreas Keller (Astoria, New York); Leslie Birgit Vosshall (New York, New York) |
| ABSTRACT | Disclosed are compositions and methods for measuring olfactory sensitivity, olfactory resolution, and combinations thereof. Such measurements can be made during a single test, or over consecutive tests, which may be performed during a single testing period, such as in a single day, or over a series of testing periods. The tests may be performed by a health care professional, or may be conveniently self-administered by the user. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160624 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4011 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172531 | Voor, Ph.D. et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Michael J. Voor, Ph.D. (Louisville, None); Stuart J. Williams, Ph.D. (Prospect, None); Maxwell Boakye, M.D. (Louisville, None) |
| ABSTRACT | Provided are bone quality and/or strength measuring devices. In some embodiments, the devices include a body and a detector disposed therein designed to interact with a bone, determine the quality and/or strength thereof, and communicate an evaluation thereof to a user. The presently disclosed devices can also include a torque and/or force sensor that facilitates placement of the device and/or that is in communication with the detector to cause the detector to evaluate the bone; an output that feedback to a user based on the quality and/or strength of the bone determined by the detector, and/or a piston that interacts with the detector to cause the detector to interact with and thereby evaluate the bone. Also provided are methods for determining if a region of a bone is appropriate for placement of an orthopedic hardware piece and methods for reducing risk of a complication of spinal surgery associated with failure of an orthopedic hardware piece. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/923830 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0053 (20130101) A61B 5/4504 (20130101) Original (OR) Class A61B 5/4566 (20130101) A61B 5/6878 (20130101) A61B 17/7001 (20130101) A61B 2017/564 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172869 | Nel et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andre E. Nel (Sherman Oaks, California); Huan Meng (Los Angeles, California); Tian Xia (Los Angeles, California); Qi Liu (Los Angeles, California); Sean Allen (Culver City, California) |
| ABSTRACT | In various embodiments immunogenic nanoparticles are provided that are capable of raising an immune response directed against one or more viral proteins and/or protein fragments. In certain embodiments the immunogenic nanoparticles raise an immune response directed against a virus (e.g., SARS-CoV-2 (2019-nCoV), SARS-CoV-2, and MERS-CoV, and the like). In certain embodiments the immunogenic nanoparticles comprise a nanoparticle formed from one or more biocompatible polymer(s), one or more viral proteins or fragments thereof encapsulated within or attached to the biocompatible polymer(s) where the viral protein or fragment thereof comprises an antigen to which an immune response is to be induced by administration of the immunogenic nanoparticle to a mammal and where the immunogenic nanoparticle further comprises an adjuvant (e.g., a STING agonist). |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/919734 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/215 (20130101) A61K 47/6937 (20170801) A61K 2039/572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172870 | Piotrowski-Daspit et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandra Piotrowski-Daspit (Wethersfield, Connecticut); Claire Albert (New Haven, Connecticut); W. Mark Saltzman (New Haven, Connecticut) |
| ABSTRACT | Nanoparticles useful for drug delivery are described. In one aspect, the nanoparticles contain poly(amine-co-ester)s or poly(amine-co-amide)s (PACE) modified with poly(ethylene glycol) (PACE-PEG), and can be optionally blended with a second PACE polymer optionally containing endgroup modifications. In another aspect, the nanoparticles contain a core containing a PACE polymer optionally containing endgroup modifications, and a polymeric surfactant non-covalently conjugated to the surface of the nanoparticles. The nanoparticles contain a peptide or protein targeting moiety that is covalently conjugated to the PACE-PEG polymer or to the surfactant on the surface of the nanoparticles via a linkage that contains a succinimide or substituted sulfone moiety, respectively. The nanoparticles provide as a versatile platform for the delivery of nucleic acids, such as mRNA. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063613 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) Original (OR) Class A61K 47/34 (20130101) A61K 47/60 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172872 | Sanders et al. |
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| FUNDED BY |
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| APPLICANT(S) | Io Therapeutics, Inc. (Spring, Texas); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin E. Sanders (Spring, Texas); Powel H. Brown (Houston, Texas); Cassandra Moyer (Houston, Texas); Abhijit Mazumdar (Houston, Texas) |
| ABSTRACT | The present specification provides improved methods of treating Her2+ cancers in which an RXR agonist and a taxane are administered to a subject having a Her2+ cancer. Thyroid hormone and other anticancer agents may also be administered. Related compositions and combination are also disclosed |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/076992 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/015 (20130101) Original (OR) Class A61K 31/56 (20130101) A61K 31/192 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172877 | Ravichandran et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Kodimangalam S. Ravichandran (, None); Christopher B. Medina (, None) |
| ABSTRACT | Disclosed aspects include characterizing of the metabolite secretome of apoptotic cells, deciphering metabolite-based communication between dying cells and neighboring live cells, and harnessing components of the secretome for beneficial effects in vivo. In representative embodiments, a composition comprising, consisting essentially of, or consisting of an effective amount of a plurality of metabolite compounds derived from an apoptotic cell is disclosed, as are methods of treating an inflammatory condition in a subject and modulating gene expression in a subject using the composition. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/910613 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/132 (20130101) Original (OR) Class A61K 31/661 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172885 | Fahy et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oaklamd, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Vincent Fahy (San Francisco, California); Irina Gitlin (San Francisco, California); Wilfred Raymond (San Francisco, California) |
| ABSTRACT | Provided herein, inter alia, are methods and compositions including thiol-containing compounds for treating coronavirus infection. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/924661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/095 (20130101) A61K 31/145 (20130101) A61K 31/185 (20130101) A61K 31/194 (20130101) A61K 31/198 (20130101) Original (OR) Class A61K 31/381 (20130101) A61K 31/661 (20130101) A61K 38/063 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 29/00 (20180101) A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172890 | Sanders et al. |
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| FUNDED BY |
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| APPLICANT(S) | Io Therapeutics, Inc. (Spring, Texas); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin E. Sanders (Spring, Texas); Powel H. Brown (Houston, Texas); Cassandra Moyer (Houston, Texas); Abhijit Mazumdar (Houston, Texas) |
| ABSTRACT | The present specification provides combinations of active agents for the improved treatment of Her2+ cancers and associated methods of treatments. The combinations comprise an RXR agonist and a Her2-targeted therapeutic agent and may optionally further comprise thyroid hormone. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/076997 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/216 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172911 | Dealwis et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chris G. Dealwis (Cleveland, Ohio); Rajesh Viswanathan (Cleveland, Ohio); Sarah E. Huff (Cleveland, Ohio); William Harte (Cleveland, Ohio) |
| ABSTRACT | A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a triazole or an oxadiazole ribonucleotide reductase modulator (RRmod), the amount being effective to inhibit neoplastic cell growth. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/943986 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4245 (20130101) Original (OR) Class A61K 31/4439 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172932 | Augelli-Szafran et al. |
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| FUNDED BY |
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| APPLICANT(S) | SOUTHERN RESEARCH INSTITUTE (Birmingham, Alabama); THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | SOUTHERN RESEARCH INSTITUTE (Birmingham, Alabama); THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| INVENTOR(S) | Corinne E. Augelli-Szafran (Homewood, Alabama); Omar Moukha-Chafiq (Birmingham, Alabama); Mark J. Suto (Homewood, Alabama); Anath Shalev (Mountain Brook, Alabama); Lance Thielen (Lenexa, Kansas); Junqin Chen (Vestavia Hills, Alabama); Gu Jing (Vestavia Hills, Alabama) |
| ABSTRACT | In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 18/052268 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/06 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172947 | Dellinger |
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| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thanh Dellinger (Azusa, California) |
| ABSTRACT | Provided herein are, inter alia, methods and compositions for treating cancer in a subject in need thereof comprising a therapeutically effective amount of a stilbenoid compound and a progestin. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/810924 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/10 (20130101) A61K 9/48 (20130101) A61K 9/0053 (20130101) A61K 9/0095 (20130101) A61K 9/2004 (20130101) A61K 31/09 (20130101) A61K 31/57 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172962 | Ambati et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Jayakrishna Ambati (Charlottesville, None); Kameshwari Ambati (Charlottesville, None) |
| ABSTRACT | Methods for treating and/or inhibiting progression of diseases, conditions, and/or disorders. In some embodiments, the methods include administering to as subject in need thereof a composition that includes a nucleoside reverse transcriptase inhibitor (NRTIs), an NRTI metabolite, an NRTI analog, a pharmaceutically acceptable salt and/or metabolite thereof, a prodrug of an NRTI, or any combination thereof. Also provided are methods for inhibiting development of macular degeneration in subjects; methods for inhibiting development and/or progression of viral infection and/or a disease, condition, disorder, and/or symptom associated therewith in a subject in need thereof; methods for inhibiting development and/or progression of acute respiratory distress syndrome in subjects; methods for inhibiting development and/or progression of cytokine storm syndrome in subjects; methods for inhibiting development and/or progression of fibrosis in subjects, and compositions for use in the presently disclosed methods. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/912805 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/513 (20130101) A61K 31/7072 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172965 | Pajvani et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Utpal Pajvani (Leonia, New Jersey); Brent Mayfield (New York, New York) |
| ABSTRACT | This invention relates to the treatment of fatty liver disease. More specifically, embodiments of the invention provide a pharmaceutical composition comprising a pharmaceutical carrier and a compound that reduces LTBP3 activity in liver cells. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154702 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 29/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172971 | RICE |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHARLES V. RICE (Norman, Oklahoma) |
| ABSTRACT | Compositions, kits, and methods of use of branched poly(ethylenimine) (BPEI) compounds, including polyethylene glycol (PEG)-branched poly(ethylenimine) conjugates (PEG-BPEI) for treatment of diseases, bacterial infections, bacterial biofilms, and conditions associated with inflammation, including wounds. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/922674 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/785 (20130101) Original (OR) Class A61K 31/7048 (20130101) A61K 31/7052 (20130101) A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 29/00 (20180101) A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172993 | SADOWSKY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Michael J. SADOWSKY (Roseville, Minnesota); Alexander KHORUTS (Golden Valley, Minnesota); Alexa R. WEINGARDEN (St. Paul, Minnesota); Matthew J. HAMILTON (Burnsville, Minnesota) |
| ABSTRACT | The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896539 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) A61K 9/0053 (20130101) A61K 9/1617 (20130101) A61K 9/1623 (20130101) A61K 35/24 (20130101) A61K 35/37 (20130101) Original (OR) Class A61K 35/74 (20130101) A61K 35/741 (20130101) A61K 35/742 (20130101) A61K 45/06 (20130101) A61K 47/08 (20130101) A61K 47/26 (20130101) A61K 2035/11 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172994 | TSENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | TissueTech, Inc. (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scheffer TSENG (Pinecrest, Florida); Frank YOUNG (Miami, Florida); Szu Yu CHEN (Miami, Florida); Ying-Tieng ZHU (Homestead, Florida) |
| ABSTRACT | Disclosed herein are methods of promoting vasculogenesis, promoting neurovasculogenesis, or treating an ischemic condition, comprising contacting a tissue with a fetal support tissue product. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/620650 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/50 (20130101) Original (OR) Class A61K 35/51 (20130101) A61K 35/545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173024 | Song et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenchao Song (Bryn Mawr, Pennsylvania); Hangsoo Kim (Nagoya, Japan); Takashi Miwa (Bala Cynwyd, Pennsylvania); Damodara Rao Gullipalli (Mount Laurel, New Jersey) |
| ABSTRACT | This invention relates to factor B inhibitors or nucleic acid molecules encoding thereof and selective inhibition of the alternative pathway (AP) of the complement system using said factor B inhibitors or nucleic acid molecules encoding thereof or compositions thereof. The invention also provides methods of treating an AP complement-mediated disease or AP complement-mediated disorder in a subject by administering a therapeutically effective amount of the factor B inhibitor or nucleic acid molecules encoding thereof or composition thereof. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/995194 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5068 (20130101) A61K 38/1725 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) Peptides C07K 14/472 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173037 | Gentry et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew S. Gentry (Lexington, Kentucky); Ramon C. Sun (Lexington, Kentucky); Lance A. Johnson (Lexington, Kentucky); Peter T. Nelson (Lexington, Kentucky); Frank Gilliam (Lexington, Kentucky) |
| ABSTRACT | A method for treating a neurodegenerative disease is provided. The method for treating a neurodegenerative disease includes administering, to a subject in need thereof, one or more of a small molecule glycogen synthase (GYS) inhibitor, an antisense oligonucleotide targeting glycogen synthase, an antibody-enzyme fusion compound targeting polyglucosan bodies (PGBs), or combinations thereof. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/908827 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/085 (20130101) A61K 31/366 (20130101) A61K 31/438 (20130101) A61K 31/4196 (20130101) A61K 31/4436 (20130101) A61K 38/47 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/18 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2414 (20130101) C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2310/531 (20130101) Enzymes C12Y 302/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173043 | Kolls et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Jay K. Kolls (Pittsburgh, Pennsylvania); Michael Zheng (Pittsburgh, Pennsylvania); Karen Norris (Pittsburgh, Pennsylvania); Heather Kling (Pittsburgh, Pennsylvania) |
| ABSTRACT | A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat fungal infections. The novel vaccine can provide protective immunity, even for immunocompromised individuals such as HIV patients having reduced levels of CD4+ T cells. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/865080 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/191 (20130101) A61K 39/00 (20130101) A61K 39/0002 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/55 (20130101) A61K 2039/545 (20130101) A61K 2039/5256 (20130101) A61K 2039/55516 (20130101) Peptides C07K 14/70575 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/58 (20130101) C12N 9/60 (20130101) Enzymes C12Y 304/21061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173049 | Yarchoan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Yarchoan (Baltimore, Maryland); Elizabeth Jaffee (Lutherville, Maryland); Aditya Mohan (Baltimore, Maryland) |
| ABSTRACT | The invention features compositions and methods for treating and preventing cancer. In one aspect, isolated fusion proteins are provided that comprise a DNAJBI portion and a PRKACA portion. In a further aspect, compositions are provided, including immunogenic compositions that comprise an isolated fusion protein comprising a DNAJBI portion and a PRKACA portion. In a yet further aspect, a cancer vaccine is provided that comprises an isolated fusion protein comprising a DNAJBI portion and a PRKACA portion. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/789858 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001162 (20180801) Original (OR) Class A61K 45/06 (20130101) Peptides C07K 14/47 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 15/625 (20130101) Enzymes C12Y 207/11011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173056 | Hartigan-O'Connor |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Dennis Hartigan-O'Connor (Oakland, California) |
| ABSTRACT | Provided herein are recombinant polynucleotides including a first nucleic acid sequence encoding an antigen, and a second nucleic acid sequence encoding an enzyme of an amino acid catabolic pathway. The provided recombinant polynucleotides are particularly useful for inducing long-lived immune responses having improved memory characteristics. Also provided are pharmaceutical compositions, viral particles, and host cells including the disclosed recombinant polynucleotides, and methods for using the disclosed materials. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 18/013863 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class A61K 39/215 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/18 (20180101) A61P 37/04 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/78 (20130101) C12N 15/86 (20130101) C12N 2740/15034 (20130101) C12N 2740/15071 (20130101) C12N 2740/16234 (20130101) C12N 2740/16271 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) C12N 2770/20034 (20130101) C12N 2770/20071 (20130101) Enzymes C12Y 305/03001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173060 | BenMohamed |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lbachir BenMohamed (Irvine, California) |
| ABSTRACT | Pan-coronavirus vaccines for inducing efficient, powerful and long-lasting protection against all Coronaviruses infections and diseases, comprising multiple highly conserved large sequences which may comprise one or more conserved B, CD4 and CD8 T cell epitopes that help provide multiple targets for the body to develop an immune response for preventing a Coronavirus infection and/or disease. In certain embodiments, the large sequences are conserved proteins or large sequences, e.g., sequences that are highly conserved among human coronaviruses and/or animal coronaviruses (e.g., coronaviruses isolated from animals susceptible to coronavirus infections). |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046875 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/70 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173070 | Papadopoulou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The Regents of the University of Colorado (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Virginie Papadopoulou (Chapel Hill, North Carolina); Paul Alexander Dayton (Carrboro, North Carolina); Sarah Elizabeth Conlon (Durham, North Carolina); Brian Patrick Conlon (Durham, North Carolina); Phillip Gregory Durham (Chapel Hill, North Carolina); Mark A. Borden (Boulder, Colorado) |
| ABSTRACT | A method for applying ultrasound to activate a cavitation enhancing agent in the presence of a therapeutic compound and a microbial biofilm is provided. The ultrasound energy causes the cavitation enhancing agent to cavitate in the ultrasound field. The cavitation of the resultant bubble causes fluid streaming and shear forces at and near the biofilm, causing enhanced penetration of the therapeutic compound into the biofilm, and resulting in improved efficacy of the therapeutic compound against the biofilm. The method further includes cavitation enhancing agents which can be loaded with oxygen gas or combined with microbubbles which carry oxygen gas, which further potentiate antibiotic efficacy against the biofilm. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/922522 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/351 (20130101) A61K 31/496 (20130101) A61K 31/538 (20130101) A61K 31/702 (20130101) A61K 31/5377 (20130101) A61K 31/7036 (20130101) A61K 33/00 (20130101) A61K 38/12 (20130101) A61K 38/15 (20130101) A61K 41/0047 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 47/12 (20130101) A61K 47/26 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0092 (20130101) A61M 2037/0007 (20130101) A61M 2202/0208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173090 | Isacoff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ehud Y. Isacoff (Berkeley, California); Prashant Chandra Donthamsetti (Oakland, California) |
| ABSTRACT | The present disclosure provides conjugates and systems for modulating the activity of a ligand-binding polypeptide such as a D1 dopamine receptor. The present disclosure provides methods of modulating the activity of a D1 dopamine receptor. The present disclosure provides methods of treating Parkinson’s disease in an individual. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/928850 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/00 (20130101) A61K 47/65 (20170801) A61K 47/545 (20170801) A61K 47/6425 (20170801) A61K 47/6849 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173097 | Ruoslahti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sanford-Burnham Medical Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erkki Ruoslahti (La Jolla, California); Tambet Teesalu (La Jolla, California); Kazuki Sugahara (La Jolla, California) |
| ABSTRACT | Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/681380 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/62 (20170801) A61K 47/64 (20170801) A61K 47/6923 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173110 | GOLDMAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. GOLDMAN (Webster, New York) |
| ABSTRACT | The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and restoring normal brain interstitial potassium levels. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/096718 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) A01K 2207/12 (20130101) A01K 2207/15 (20130101) A01K 2227/105 (20130101) A01K 2267/0318 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) A61K 35/545 (20130101) A61K 45/06 (20130101) A61K 49/0008 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/06 (20130101) C12N 5/0622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101) G01N 33/5085 (20130101) G01N 2800/28 (20130101) G01N 2800/2814 (20130101) G01N 2800/2821 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173141 | LIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wanjun LIU (Ithaca, New York); Minglin MA (Ithaca, New York); James A. FLANDERS (Ithaca, New York); Longhai WANG (Ithaca, New York); Daniel T. BOWERS (Ithaca, New York); Qingsheng LIU (Ithaca, New York) |
| ABSTRACT | The present application relates to implantable therapeutic delivery system, its method of making and use. The therapeutic delivery system includes a nanofiber core substrate having proximal and distal ends, and an interior nanofiber wall defining an internal space extending longitudinally along the core substrate, with one or more therapeutic agents positioned within the internal space. A hydrogel surrounds the nanofiber core substrate, where the hydrogel includes 0.1% to 20% of an alginate mixture. The alginate mixture includes zwitterionically modified alginate and pure alginate in a ratio of 1:1000 to 1000:1 (v/v). Also disclosed is a thermo sealing device useful for the formation of the implantable therapeutic delivery system. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/916215 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/34 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) Original (OR) Class A61L 27/56 (20130101) A61L 2400/12 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173156 | Roy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shuvo Roy (San Ramon, California); William Fissell (Brentwood, Tennessee); Nathan Wright (San Francisco, California); Mark Goodin (Hudson, Ohio); Steven G. Goebel (Victor, New York); Amanda Buck (Nashville, Tennessee); Joey Groszek (Nashville, Tennessee) |
| ABSTRACT | Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/986397 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/34 (20130101) Original (OR) Class A61M 1/1621 (20140204) A61M 1/1631 (20140204) A61M 1/1678 (20130101) A61M 5/165 (20130101) A61M 2205/04 (20130101) A61M 2205/75 (20130101) A61M 2205/3334 (20130101) A61M 2206/11 (20130101) Separation B01D 63/082 (20130101) B01D 63/085 (20130101) B01D 2313/105 (20130101) B01D 2313/125 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2009/029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173203 | LONGEST et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Worth LONGEST (Richmond, Virginia); Dale FARKAS (Richmond, Virginia); Karl BASS (Richmond, Virginia); Michael HINDLE (Richmond, Virginia) |
| ABSTRACT | Exemplary embodiments include dry powder inhalers (DPIs) and patient interfaces which improve delivery of aerosols to patients, especially children. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/794660 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 15/0021 (20140204) Original (OR) Class A61M 15/0086 (20130101) A61M 2202/064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173255 | Brooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin Brooks (Lincoln, Nebraska); Ruiguo Yang (Lincoln, Nebraska); Ikhlaas Mungloo (Lincoln, Nebraska) |
| ABSTRACT | Electroporation devices and methods of making the same. An electroporation device includes a plurality of independently controllable or addressable electrode pairs, a plurality of reaction chambers, each reaction chamber including a first chamber, a second chamber and a porous substrate separating the first chamber from the second chamber, and each reaction chambers being disposed between one of the plurality of independently controllable or addressable electrode pairs, a plurality of first microfluidic channels configured to deliver a cargo solution from a cargo inlet port to the plurality of first chambers, and a plurality of second microfluidic channels configured to deliver a cell culture from a cell inlet port to the plurality of second chambers. In operation, application of a voltage to an electrode pair permeabilizes the membranes of the cells adhered to the porous substrate in the reaction chamber disposed between the electrode pair. |
| FILED | Wednesday, September 21, 2022 |
| APPL NO | 17/933947 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) A61N 1/0408 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173256 | Risi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cochlear Limited (Macquarie University, Australia); University of Washington Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank Risi (Newtown, Australia); Colin Irwin (Nice, France); Jay T. Rubinstein (Seattle, Washington); Felipe Santos (Boston, Massachusetts); James O. Phillips (Seattle, Washington) |
| ABSTRACT | A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/162340 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/361 (20130101) A61N 1/0526 (20130101) Original (OR) Class A61N 1/0551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173292 | Rubin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clinton Rubin (Port Jefferson, New York); Janet Rubin (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/969131 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/00 (20130101) A61M 31/002 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/05 (20130101) A61N 2/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173294 | Lu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Hanbing Lu (Ellicott City, Maryland); Qinglei Meng (Catonsville, Maryland); Hieu Nguyen (Baltimore, Maryland); Yihong Yang (Ellicott City, Maryland) |
| ABSTRACT | A system for administering transcranial magnetic stimulation to a subject is provided. The system includes a coil a controller, and a high-power switching module. The controller is configured to generate low voltage control signals for administering a treatment protocol via the coil. The high-power switching module is configured to generate a high voltage current delivered to the coil based on the low voltage control signals. In some embodiments, the high-power switching module includes a printed circuit board used to reduce intrinsic resistance and parasitic capacitance of the circuit such that the current delivered to the coil over a sequence of bursts remains stable. A new protocol for administering transcranial magnetic stimulation, referred to as high-density Theta Burst Stimulation (hdTBS), utilizes a pulse frequency of at least 40 Hz and a number of pulses per burst of four or greater. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/076071 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) Original (OR) Class A61N 2/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173296 | POTASEK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Simphotek, Inc. (Newark, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mary POTASEK (Princeton, New Jersey); Karl BEESON (Princeton, New Jersey); Evgueni PARILOV (Brooklyn, New York) |
| ABSTRACT | A method of generating a treatment plan for delivering treatment light for intracavitary photodynamic therapy to a targeted region within a cavity of a patient may include receiving shape information for an interior surface of the cavity. A first set of control points located on a first trajectory within the cavity is initialized by assigning, to each of the first set of control points, one or more axis positions of a treatment light emitter relative to the interior surface of the cavity. A simulated total treatment dose is iteratively optimized relative to a set of one or more optimization goals when the treatment light emitter is activated to emit treatment light at each of the first set of control points. The treatment plan is then generated to provide a total treatment dose to the targeted region. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/997870 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 5/0603 (20130101) Original (OR) Class A61N 2005/063 (20130101) A61N 2005/0626 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173300 | Green |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hadiyah-Nicole Green (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hadiyah-Nicole Green (Atlanta, Georgia) |
| ABSTRACT | Methods, structures, devices and systems are disclosed for implementing a photothermal therapy using nanostructures. In one aspect, a device to produce a photothermal effect includes a particle having a molecular layer functionalized onto the external surface of the particle and structured to attach to one or more targeting molecules capable of binding to a receptor site of a cell, in which the particle is configured to absorb light energy at a particular wavelength to produce a plasmon resonance effect that causes the particle to emit heat energy. In some implementations, the device is deployed in an organism having a tumor that includes a plurality of the cell and binds to the receptor site of the tumor by the targeting molecules, in which the light energy is emitted at a region of the organism that contains the tumor and the heat energy causes cellular death of the tumor cell. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/159860 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 2005/063 (20130101) A61N 2005/0644 (20130101) A61N 2005/0659 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 3/108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173301 | Shafirstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Health Research, Inc. (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gal Shafirstein (Amherst, New York); David Bellnier (Buffalo, New York) |
| ABSTRACT | The present disclosure provides a method and a system for treating a tissue using photodynamic therapy (PDT). A photosensitizer is administered to the tissue and one or more optical fibers are placed in the tissue. A treatment light is applied to the tissue by way of the one or more optical fibers. A temperature of the tissue is measured during application of the treatment light, and a fluence rate of the treatment light is modified based on the temperature of the tissue. For example, the fluence rate may be modified to be lower if the temperature of the tissue is higher than a predetermined threshold. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/162995 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 5/0601 (20130101) A61N 2005/063 (20130101) A61N 2005/0612 (20130101) A61N 2005/0628 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173449 | De Rutte et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Joseph De Rutte (Los Angeles, California); Dino Di Carlo (Los Angeles, California); Sohyung Lee (Los Angeles, California) |
| ABSTRACT | A method of fabricating shaped particles is disclosed. The method involves generating a plurality of droplets within dispersion media (e.g., oil and surfactant), the plurality of droplets formed from a mixture of precursor materials that are in a miscible state. A stimulus or change of conditions is then introduced to the droplets so as to cause the mixture of precursor materials to become immiscible and phase-separate from one another. The phase-separated droplets are then crosslinked to form shaped particles. The stimulus or change of conditions may include one or more of the following: a change in temperature, a change in pH, a change in osmolarity, a change composition of the droplets, a change in the composition of the dispersion media. The shaped particles may be washed to remove un-crosslinked material and one or more affinity capture agents may be immobilized onto the shaped particles. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/996927 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/14 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/585 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173489 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Di Wu (Pasadena, California); Mikhail G. Shapiro (Pasadena, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in sorting a population of cells. In some embodiments, the method comprises flowing a fluid sample comprising a population of cells through a microfluidic channel. The population of cells can be configured to express gas vesicles (GVs) in a context-dependent manner. The expression of GVs within a cell can increase the compressibility (β) and reduce the density (ρ) of said cell, thereby modulating the acoustic contrast (Φ) of said cell relative to the fluid in the microfluidic channel. The method can comprise applying ultrasound to the microfluidic channel. Applying ultrasound can generate acoustic standing wave(s) in the microfluidic channel, thereby positioning pressure antinode(s) in the microfluidic channel. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/073102 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0654 (20130101) B01L 2400/0436 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 5/0686 (20130101) C12N 15/70 (20130101) C12N 15/85 (20130101) C12N 2800/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174506 | DAI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingii DAI (Alpharetta, Georgia) |
| ABSTRACT | One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/060922 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 229/34 (20130101) Heterocyclic Compounds C07D 209/50 (20130101) C07D 211/14 (20130101) C07D 211/62 (20130101) C07D 263/56 (20130101) C07D 295/145 (20130101) C07D 311/16 (20130101) C07D 333/34 (20130101) C07D 401/06 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 403/06 (20130101) C07D 405/14 (20130101) C07D 409/12 (20130101) C07D 409/14 (20130101) C07D 413/14 (20130101) C07D 491/107 (20130101) Steroids C07J 43/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174548 | Natarajan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amarnath Natarajan (Elkhorn, Nebraska) |
| ABSTRACT | Provided herein are compounds and methods for modulating the NFKB pathway. More particularly, provided are inhibitors of the NFkB pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, such as ovarian cancer. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/912706 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/08 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 491/107 (20130101) Original (OR) Class C07D 493/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174574 | WOOD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Webster WOOD (Dublin, Ohio); Joseph TARIS (Columbus, Ohio) |
| ABSTRACT | Disclosed herein is a protein purification system and methods of making such a system. Specifically, the invention relates to a method of immobilizing an N-terminal intein segment to a solid support, the method comprising: exposing an N-terminal intein segment to a cognate folding partner under conditions that promote association between the N-terminal intein and the cognate folding partner; immobilizing the N-terminal intein to a solid support; subjecting the N-terminal intein to conditions that disrupt association between the N-terminal intein and the cognate folding partner; and washing the solid support to remove non-bound material, thereby immobilizing an N-terminal intein segment to a solid support. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/922472 |
| CURRENT CPC | Peptides C07K 1/22 (20130101) Original (OR) Class C07K 14/47 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174587 | Kwong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH and HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Peter Kwong (Washington, District of Columbia); Guillaume Stewart-Jones (Cambridge, Massachusetts); Jason Gorman (New York, New York); Li OU (Potomac, Maryland); Tongqing Zhou (Boyds, Maryland); Baoshan Zhang (Bethesda, Maryland); Wing-Pui Kong (Germantown, Maryland); Yaroslav Tsybovsky (Brunswick, Maryland); John Mascola (Rockville, Maryland); Peter Collins (Kensington, Maryland); Ursula Buchholz (Silver Spring, Maryland) |
| ABSTRACT | Metapneumovirus (HMPV) F ectodomain trimers stabilized in a prefusion or postfusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the HMPV F ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HMPV in a subject. In additional embodiments, the therapeutically effective amount of the HMPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing HMPV infection. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/919733 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2299/00 (20130101) C07K 2319/03 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18322 (20130101) C12N 2760/18334 (20130101) C12N 2760/18371 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174593 | RULLAN-LIND et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PUERTO RICO (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlos Ralph RULLAN-LIND (San Juan, Puerto Rico); Abel Juan BAERGA-ORTIZ (San Juan, Puerto Rico) |
| ABSTRACT | The disclosure provides artificially linked acyl earner proteins that enhance fatty acid biosynthesis and methods for mating the artificially linked acyl earner proteins. The fused dimer comprises acyl carrier proteins and peptide linkers. |
| FILED | Tuesday, August 18, 2020 |
| APPL NO | 17/636470 |
| CURRENT CPC | Peptides C07K 14/28 (20130101) C07K 14/245 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174595 | Matoba |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nobuyuki Matoba (Owensboro, Kentucky) |
| ABSTRACT | Polypeptides are provided that include an actinohivin variant polypeptide. The actinohivin variant polypeptide can be operably connected to an antibody fragment, such as a fragment crystallizable (Fc) region of immunoglobulin (Ig) G. Nucleic acid sequences, expression vectors, and transformed plant cells useful for producing the polypeptides are also provided. Further provided are methods for treating a viral infection or a cancer in a subject and include the step of administering the actinohivin variant polypeptide to the subject. |
| FILED | Friday, February 09, 2018 |
| APPL NO | 16/485021 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 11/00 (20180101) A61P 31/18 (20180101) A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 14/36 (20130101) Original (OR) Class C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174600 | McCray, JR. et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul B. McCray, JR. (Iowa City, Iowa); Patrick Sinn (Iowa City, Iowa); Laura Marquez Lora (Iowa City, Iowa) |
| ABSTRACT | Provided herein are polynucleotides, lentiviral vectors, pharmaceutical compositions, and methods of making and using the same, e.g., for treatment of cystic fibrosis (CF). |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/921510 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0078 (20130101) A61K 45/06 (20130101) A61K 48/0058 (20130101) Peptides C07K 14/4712 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15043 (20130101) C12N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174611 | KOLLS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Administrators of the Tulane Educational Fund (New Orleans, Louisiana) |
| ASSIGNEE(S) | Administrators of the Tulane Educational Fund (New Orleans, Louisiana) |
| INVENTOR(S) | Jay K KOLLS (New Orleans, Louisiana); Naoki IWANAGA (New Orleans, Louisiana) |
| ABSTRACT | The invention provides compositions and methods for preventing, or reducing the effects of, an infection by coronaviruses, including SARS-CoV-2, that bind human ACE2. The compositions are fusion proteins with mutated forms of the extracellular domain of the ACE2 receptor which can bind viral particles of these coronaviruses. When sprayed or inhaled into an individual’s nasal passages or airway, the inventive fusion proteins bind particles of such coronaviruses, keeping them from reaching and infecting the individual’s cells. When administered parenterally, the fusion proteins can enter the fluid lining the inside of the lung, binding particles of such coronaviruses and keeping them from binding to and infecting cells. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/919507 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/705 (20130101) Original (OR) Class C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174612 | ROYBAL et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kole T. ROYBAL (San Francisco, California); Iowis ZHU (San Francisco, California); Raymond LIU (San Francisco, California); Ahmad S. KHALIL (Boston, Massachusetts); Divya ISRANI (Boston, Massachusetts) |
| ABSTRACT | The present disclosure generally relates to, inter alia, a new class of chimeric Notch receptors containing a synthetic zinc finger transcriptional effector (synZTE) module, engineered to modulate gene expression and cellular activities in a ligand-dependent manner. The new Notch receptors surprisingly retain the ability to transduce signals in response to ligand binding despite that the Notch extracellular subunit (NEC), which includes the negative regulatory region (NRR) previously believed to be essential for the functioning of Notch receptors, is partly or completely deleted. In addition, the synZTE is designed to bind orthogonal DNA target sequences in target organisms which in turn facilitates precise regulation of therapeutic gene expression with minimal off-target activity. Also provided are compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/995765 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class C07K 14/70517 (20130101) C07K 16/2803 (20130101) C07K 2317/24 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/035 (20130101) C07K 2319/81 (20130101) C07K 2319/715 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174614 | FRY |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Terry J FRY (Denver, Colorado); The Regents of the University of Colorado, A Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Terry J. FRY (Denver, Colorado) |
| ABSTRACT | The present disclosure provides multispecific chimeric antigen receptors (CARs) having antigenic specificity for FLT3 and CD19, FLT3 and CD22, FLT3 and CD123 or FLT3 and CD33. Nucleic acids, expression constructs, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the multispecific CARs are disclosed. Methods of treating or preventing ALL, AML and/or other forms of cancer in a mammal are also disclosed. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/997575 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/70503 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174618 | Jaeger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carla A. Jaeger (Seattle, Washington); Colin E. Correnti (Seattle, Washington); Stanley R. Riddell (Sammamish, Washington) |
| ABSTRACT | Engineered trimeric CD70 proteins for use in ex vivo T cell manufacturing are described. Use of the proteins during manufacturing creates expanded T cell populations with enhanced properties such as earlier proliferation in culture; selective expansion of nave and memory T cell subsets; longer persistence in vivo following administration to a subject; and improved therapeutic effect. Use of the proteins as therapeutics provide anti-cancer and anti-viral effects. The proteins can also be used as agonistic cell culture reagents in in vitro uses. |
| FILED | Thursday, October 08, 2020 |
| APPL NO | 17/767843 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2039/5156 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/00 (20130101) C07K 14/21 (20130101) C07K 14/78 (20130101) C07K 14/7051 (20130101) C07K 14/7056 (20130101) C07K 14/43504 (20130101) C07K 14/43563 (20130101) C07K 14/70517 (20130101) C07K 14/70575 (20130101) Original (OR) Class C07K 14/70578 (20130101) C07K 2319/20 (20130101) C07K 2319/21 (20130101) C07K 2319/22 (20130101) C07K 2319/30 (20130101) C07K 2319/41 (20130101) C07K 2319/42 (20130101) C07K 2319/43 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174623 | WITTRUP et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl Dane WITTRUP (Boston, Massachusetts); Noor MOMIN (Cambridge, Massachusetts); Joseph PALMERI (Cambridge, Massachusetts); Magnolia CHINN (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides immunomodulatory fusion proteins comprising a collagen-binding domain operably linked to an immunomodulatory domain. The disclosure also features compositions and methods of using the same, for example, to treat cancer. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 18/056825 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/001104 (20180801) A61K 39/001106 (20180801) A61K 39/001129 (20180801) Peptides C07K 14/78 (20130101) Original (OR) Class C07K 14/473 (20130101) C07K 14/4741 (20130101) C07K 14/7051 (20130101) C07K 14/7155 (20130101) C07K 14/70521 (20130101) C07K 14/70532 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174629 | McIlwain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin C. McIlwain (Ann Arbor, Wisconsin); Randy B. Stockbridge (Ann Arbor, Michigan) |
| ABSTRACT | Disclosed herein are compositions and methods for determining the structure of a membrane protein. An epitope from a membrane-proximal external region (MPER) from a viral envelope protein can be grafted on to a variety of diverse membrane proteins to allow for binding structurally characterized antibody fragments, which can aid structural studies. t,25 |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/997720 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/622 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174633 | GEISSMANN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederic GEISSMANN (New York, New York); Nehemiah COX (New York, New York) |
| ABSTRACT | The present technology provides compositions and methods for the treatment of diseases associated with abnormal lipid accumulation. In some embodiments, the present technology also provides methods of treating lipodystrophy, and disorders characterized by abnormal lipid accumulation and/or lipid storage in adipose tissue. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/915990 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1858 (20130101) A61K 38/1866 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 35/00 (20180101) Peptides C07K 16/22 (20130101) Original (OR) Class C07K 16/2866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174668 | PLUVINAGE et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Vincent PLUVINAGE (Atherton, California); Anton WYSS-CORAY (Palo Alto, California) |
| ABSTRACT | Provided herein are compositions and methods to treat lysosomal storage disorders. In particular, provided herein are compositions, methods, kits and uses for inhibition or modification of soluble CD22 (sCD22) and its ligand interactions as therapeutic targets in lysosomal storage disorders including Niemann-Pick Disease Type C. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/924612 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Peptides C07K 16/2863 (20130101) C07K 16/2896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174679 | SCHOENFISCH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (CHAPEL HILL, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MARK H. SCHOENFISCH (CHAPEL HILL, North Carolina); MONA JASMINE R. AHONEN (CHAPEL HILL, North Carolina); LEI YANG (CARRBORO, North Carolina); HAIBAO JIN (CARRBORO, North Carolina); EVAN SCOTT FEURA (CARRBORO, North Carolina); SARA ELIZABETH MALONEY (CHAPEL HILL, North Carolina) |
| ABSTRACT | Several embodiments of NO releasing structures are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The covalently modified polymer structures may be tailored to release nitric oxide in a controlled manner and are useful for treatment of various medical conditions. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/806323 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 31/717 (20130101) A61K 31/726 (20130101) A61K 31/728 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/34 (20130101) A61L 2300/404 (20130101) Polysaccharides; Derivatives Thereof C08B 15/04 (20130101) Original (OR) Class C08B 37/0063 (20130101) C08B 37/0072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174690 | Izgu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Enver Izgu (Piscataway, New Jersey); Zhaojun Jia (Piscataway, New Jersey) |
| ABSTRACT | Compositions and methods for functionalizing a variety of surfaces are provided herein. The compositions include compounds of formula (I), which react with azido compounds (R-N3) to form cycloadducts that can spontaneously polymerize on a surface. The R-group in the azido compound can be any molecule of interest, including small molecules and macromolecules |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/789057 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 38/02 (20130101) Original (OR) Class C08F 138/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174912 | HE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoming HE (Bethesda, Maryland) |
| ABSTRACT | The disclosure relates generally to a system, device, and method for cell culturing. In certain embodiments, the system, device, and method may be used to encapsulate single cells in embryo-like, core-shell microcapsules. In some embodiments, microfluidic devices may be utilized to fabricate core-shell hydrogel microcapsules, which may be used to encapsulate individual cells. In some embodiments, the disclosed system and method are utilized to encapsulate cancer stem cells. The disclosed system, device, and method can be used to isolate and culture CSCs, to facilitate the understanding of cancer biology and etiology, and to advance the development of effective CSC-targeted cancer therapies. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/920440 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 25/16 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 2533/74 (20130101) C12N 2533/78 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174934 | O'Neil et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard T. O'Neil (Nashville, Tennessee); Matthew H. Wilson (Nashville, Tennessee) |
| ABSTRACT | Disclosed herein are engineered cell-based peptide delivery platforms based on T cells lacking Perforin function. Perforin-null T cells lack cytotoxic effector function and thus are not capable of killing target cells by conventional Perforin dependent pathways. However, they efficiently home to target tissues where they can invade, persist, and proliferate. The homing ability of perforin lacking T cells can therefore be used to deliver anti-cancer or pre-immune peptides to tumors, or therapeutic peptides to other target tissues based on antigen recognition. Because the cells lack cytotoxic effector function due to loss, knockdown, or inhibition of Perforin, they can be targeted to tissues based on antigen recognition without destroying the target tissue directly. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/996963 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174945 | KIMURA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | KANEKA CORPORATION (Osaka-shi, Osaka, Japan); NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE (Tokyo, Japan) |
| ASSIGNEE(S) | KANEKA CORPORATION (Osaka-shi, Osaka, Japan); NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE (Tokyo, Japan) |
| INVENTOR(S) | Keiichi KIMURA (Asaka-shi, Japan); Masato IBUKI (Kawagoe-shi, Japan); Hitoshi OKOCHI (Tokyo, Japan); Shigeharu YABE (Tokyo, Japan) |
| ABSTRACT | A method for inducing differentiation into pancreatic α cells includes: a step (a) of culturing endodermal cells, which have been induced to differentiate from pluripotent stem cells, in the presence of a bone morphogenetic protein (BMP) signaling inhibitor, and retinoic acid or a retinoic acid analog to induce differentiation into primitive gut tube (PGT) cells; a step (b) of culturing the primitive gut tube (PGT) cells to induce differentiation into pancreatic endocrine precursor (EP) cells; and a step (c) of culturing the pancreatic endocrine precursor (EP) cells to induce differentiation into pancreatic α cells, in which the step (b) and the step (c) are performed in the absence of ascorbic acid. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/912747 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0676 (20130101) Original (OR) Class C12N 2500/02 (20130101) C12N 2500/05 (20130101) C12N 2500/24 (20130101) C12N 2500/38 (20130101) C12N 2501/15 (20130101) C12N 2501/33 (20130101) C12N 2501/42 (20130101) C12N 2501/72 (20130101) C12N 2501/105 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2506/23 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174946 | Stripp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Barry R. Stripp (Malibu, California); Apoorva Mulay (Los Angeles, California); Bindu Konda (Redondo Beach, California); Arun Sharma (Los Angeles, California); Clive Svendsen (Pacific Palisades, California); Vaithilingaraja Arumugaswami (Los Angeles, California); Dhruv Sareen (Porter Ranch, California); Hanan Shaharuddin (Sun Valley, California); Victoria Wang (San Diego, California); Roberta S. Santos (Los Angeles, California) |
| ABSTRACT | Described herein are particular infection model systems, methods of studying infection, and method of screening compounds in various model systems. Particularly, SARS-CoV-2 is studied in these organ and infection models. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/922162 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 5/0676 (20130101) Original (OR) Class C12N 5/0688 (20130101) C12N 2503/02 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174949 | Mali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Mali (La Jolla, California); Amir Dailamy (La Jolla, California); Udit Parekh (La Jolla, California) |
| ABSTRACT | Provided are methods and compositions for tissue engineering including methods and compositions for the generation of vascularized organoids in vitro. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/074402 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2501/60 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174952 | Pokorski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Pokorski (San Diego, California); Nicole Steinmetz (San Diego, California); Parker Lee (Los Angeles, California) |
| ABSTRACT | A method of producing plant virus-like particles includes freeze drying an aqueous solution of plant virus particles to produce a substantially RNA-free plant virus-like particles. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868144 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2770/18023 (20130101) C12N 2770/18051 (20130101) C12N 2770/32023 (20130101) C12N 2770/32051 (20130101) Enzymes C12Y 301/27005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174982 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE METHODIST HOSPITAL SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nan ZHANG (Houston, Texas); Tetsuo ASHIZAWA (Seabrook, Texas) |
| ABSTRACT | The present disclosure relates to engineered nucleic acids that target CAG repeat sequences or viral polynucleotides. The present disclosure also relates to the uses of the engineered nucleic acids for treating polyglutamine diseases or a viral infection. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/910622 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/127 (20130101) C12N 2310/3181 (20130101) C12N 2310/3231 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174987 | Bennett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ionis Pharmaceuticals, Inc. (Carlsbad, California); University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | Ionis Pharmaceuticals, Inc. (Carlsbad, California); University of Rochester (Rochester, New York) |
| INVENTOR(S) | C. Frank Bennett (Carlsbad, California); Susan M. Freier (San Diego, California); Robert A. MacLeod (San Diego, California); Sanjay K. Pandey (Encinitas, California); Charles A. Thornton (Rochester, New York); Thurman Wheeler (Rochester, New York); Seng H. Cheng (Natick, Massachusetts); Andrew Leger (Boston, Massachusetts); Bruce M. Wentworth (Northborough, Massachusetts) |
| ABSTRACT | Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/814120 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/00 (20180101) A61P 25/18 (20180101) A61P 35/00 (20180101) A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/341 (20130101) C12N 2310/346 (20130101) C12N 2310/3181 (20130101) C12N 2310/3231 (20130101) C12N 2310/3341 (20130101) C12N 2310/3525 (20130101) Enzymes C12Y 207/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174988 | Devlin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc (Boston, Massachusetts) |
| INVENTOR(S) | Abigail Sloan Devlin (Cambridge, Massachusetts); Snehal N. Chaudhari (Cambridge, Massachusetts); Eric Garland Sheu (Brookline, Massachusetts); David A. Harris (Middleton, Wisconsin) |
| ABSTRACT | The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Selective transport of the microbial metabolite lithocholic acid (LCA) from the gut to the liver after bariatric surgery activates hepatic vitamin D receptor (VDR), thereby inducing expression of bile acid sulfotransferase SULT2A, which produces the antidiabetic molecule CA7S. Provided herein is a method for treating diabetes, obesity, or an inflammatory disease in a subject, the method comprises administering to a subject in need thereof a compound of Formula I-XV or Formula F-XV′ or an agent that increases levels or activity or cholic acid 7-sulfate or upstream targets in a subject. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/923891 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/575 (20130101) Steroids C07J 9/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175015 | YOUNG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MYOGENE BIO LLC (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Courtney YOUNG (San Diego, California); Melissa SPENCER (San Diego, California); April PYLE (San Diego, California) |
| ABSTRACT | Provided are methods related generally to the fields of molecular biology and virology, in particular the use of immunosuppressive agents and methods for treating using gene therapy, notably Duchenne muscular dystrophy. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/998454 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/225 (20130101) A61K 31/436 (20130101) A61K 31/519 (20130101) A61K 31/573 (20130101) A61K 31/5377 (20130101) A61K 38/1774 (20130101) A61K 38/2013 (20130101) A61K 39/3955 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175065 | KAMITAKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Nolan KAMITAKI (Cambridge, Massachusetts); Steven MCCARROLL (Cambridge, Massachusetts) |
| ABSTRACT | As described herein, the present invention features compositions and methods for evaluating the propensity of a subject for having or developing an autoimmune and/or inflammatory disease or disorder and for treating autoimmune and inflammatory diseases or disorders. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/923872 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 16/40 (20130101) C07K 2317/24 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175069 | WANG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEAL TH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaosong WANG (Sewickley, Pennsylvania) |
| ABSTRACT | Disclosed herein are compositions and methods for detecting ESR1/CCDC170 gene fusions relating to cancer. Also disclosed herein are compositions and methods for diagnosing and treating cancers that include detecting an ESR1/CCDC170 gene fusion. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/922027 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 14/721 (20130101) C07K 14/4738 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175071 | Wong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Wong (Beverly Hills, California); Fang Wei (Northridge, California); Charles Strom (San Clemente, California); Michael Tu (Cupertino, California); Wei Liao (Northridge, California); Jordan Cheng (Oakland, California); David Chia (Oakland, California); Hieu Tang (Westminster, California); Qianlin Ye (Oakland, California); Feng Li (Oakland, California) |
| ABSTRACT | A liquid biopsy system and method for the detection of biomarkers in bodily fluids is described. In particular, the system is suitable for detecting biomarkers of lung cancer in a subject. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/998051 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 2300/0645 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175072 | Zheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Li Zheng (Arcadia, California); Binghui Shen (La Verne, California); Haitao Sun (Duarte, California); Mian Zhou (Duarte, California) |
| ABSTRACT | Provided herein, inter alia, are methods of detecting 3′ flap Okazaki fragments for treating and diagnosing cancer. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/073397 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175077 | CHIOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CENTERS FOR DISEASE CONTROL, MINISTRY OF HEALTH AND WELFARE (Taipei City, Taiwan) |
| ASSIGNEE(S) | CENTERS FOR DISEASE CONTROL, MINISTRY OF HEALTH AND WELFARE (Taipei City, Taiwan) |
| INVENTOR(S) | Chien-Shun CHIOU (Taichung City, Taiwan); Hui-Yung SONG (Taichung, Taiwan); Bo-Han CHEN (Taichung, Taiwan); Yu-Ping HONG (Taichung, Taiwan); Min-Chi LU (Taichung, Taiwan); Hui-Ling TANG (Taichung City, Taiwan) |
| ABSTRACT | Provided is a diagnostic system for identifying target microorganisms and/or resistance genes in a sample, including a cell lysis unit, a target nucleic acid enriching unit, a sequencing unit, and a sequence analyzing unit, wherein the cell lysis unit is configured to lyse non-target cells in the sample, the target nucleic acid enriching unit equipped with an immobilized adsorption device is configured to deplete nucleic acids of the non-target cells and to enrich nucleic acids of the target microorganisms, and the sequencing unit and the sequence analyzing unit are configured to produce identification results of the microbial species and/or resistance genes from the sequences of the enriched nucleic acids. Also provided is a method for enriching target nucleic acids in a sample and a method for identifying target microorganisms and/or resistance genes by sequencing the enriched nucleic acids of the target microorganisms. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/062181 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175948 | Lo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yu-Hwa Lo (San Diego, California); Chun Hao Randy Chen (Arcadia, California); Sung Hwan Cho (La Jolla, California); Shang-Feng Tsai (Sunnyvale, California) |
| ABSTRACT | Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and diagnostic measurements. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/161800 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1425 (20130101) Original (OR) Class G01N 15/1434 (20130101) G01N 15/1459 (20130101) G01N 15/1484 (20130101) G01N 2015/145 (20130101) G01N 2015/1006 (20130101) G01N 2015/1415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175965 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Ji-Xin Cheng (Newton, Massachusetts); Yi Zhang (Boston, Massachusetts); Cheng Zong (Boston, Massachusetts) |
| ABSTRACT | Microscopic analysis of a sample includes a fluorescent dye disposed within the sample. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. An optical source generates a probe beam directed to impinge on the sample. A detector detects fluorescent emissions from the sample when the probe beam impinges on the sample. A data acquisition and processing system acquires and processes the detected fluorescent emissions from the sample to: (i) generate a signal indicative of infrared absorption by the sample, (ii) generate a signal indicative of temperature in the sample based on the signal indicative of infrared absorption by the sample, (iii) generate an image of the sample using the signal indicative of temperature in the sample. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080481 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) Original (OR) Class G01N 33/5044 (20130101) G01N 2021/655 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176040 | Montell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Denise Montell (Santa Barbara, California); Ho Lam Tang (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of anastasis, i.e., the process of reversal of apoptosis. More specifically, the present invention provides methods and compositions useful for studying anastasis. In one embodiment, the present invention provides an in vivo biosensor comprising (a) a transcription factor complex comprising the Gal4 transcription factor linked to an enzyme cleavable linker, wherein the transcription factor complex is tethered to the plasma membrane via a transmembrane domain; and (b) a reporter system comprising (1) a first nucleic acid encoding flippase operably linked to the upstream activating sequence that binds Gal4; and (2) a second nucleic acid comprising an FRT-flanked stop codon cassette separating a constitutive promoter and a fluorescent protein open reading frame. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/854989 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2227/105 (20130101) A01K 2267/0393 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/5091 (20130101) Original (OR) Class G01N 33/6872 (20130101) G01N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176041 | Dawson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ted Dawson (Baltimore, Maryland); Valina Dawson (Baltimore, Maryland); Tae-In Kam (Baltimore, Maryland); Liana Rosenthal (Lutherville, Maryland); Shaida Andrabi (Birmingham, Alabama) |
| ABSTRACT | Poly(ADP-ribose) (PAR) is a protein implicated in numerous neurodegenerative disease states including Parkinson's disease (PD). To date, no routine laboratory test has been developed to diagnosis, assess or monitor patients suffering from PD. Disclosed herein a novel method to assess the PAR concentration in the cerebral spinal fluid (CSF) of a patient and correlate that concentration to the medical condition of a patient with PD. Also disclosed is the use of PAR as a biomarker for PD. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 18/049773 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176057 | Wells et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. Wells (Oakland, California); Susanna Elledge (Oakland, California); Xin Zhou (Oakland, California); Tanja Kortemme (Oakland, California); Jeff Glasgow (Oakland, California); Anum Glasgow (Oakland, California); Irene Lui (Oakland, California) |
| ABSTRACT | Provided herein are protein biosensors, fusion proteins, compositions, and methods that are useful in detecting SARS-CoV-2 viruses in a sample from a subject. The viral detection assays described herein are solution-based, rapid, and quantitative. The protein biosensors and fusion proteins herein are able to bind to SARS-CoV-2 viral proteins. Use of the fusion proteins in proximity assays (e.g., split reporter assays) allows sensitive detection of SARS-CoV-2 virus in samples. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/997875 |
| CURRENT CPC | Peptides C07K 16/10 (20130101) C07K 2319/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54386 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176068 | Wang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHAN ZUCKERBERS BIOHUB, INC. (San Francisco, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taia Wang (Main Quad, California) |
| ABSTRACT | The present disclosure provides materials and methods for identifying patients that are at risk of progression to clinically significant COVID-19 infection or disease. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/923672 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 33/56983 (20130101) G01N 2440/38 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176069 | Hunt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald F. Hunt (Charlottesville, Virginia); Jeffrey Shabanowitz (Charlottesville, Virginia); Robert Anthony D’Ippolito (Frederick, Maryland); Maria C. Panepinto (Charlottesville, Virginia); Keira Mahoney (Charlottesville, Virginia) |
| ABSTRACT | The presently disclosed subject matter relates to a method for characterizing a protein. The method can comprise disposing a protein in a digestion buffer; disposing a hydrolyzing agent inhibitor in the digestion buffer; passing the digestion buffer comprising said protein and said hydrolyzing agent inhibitor through a reaction chamber comprising at least one hydrolyzing agent, wherein said protein contacts said hydrolyzing agent in the presence of said inhibitor and is present in the chamber for a period of time (t) sufficient to produce protein fragments and provide digestion of said protein in the chamber, wherein the passing of the digestion buffer comprising the protein and the hydrolyzing agent inhibitor through the chamber is done at an adjustable flow rate; and performing multi-segment liquid chromatography tandem mass spectrometry (LC MS/MS) to characterize the protein. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/796203 |
| CURRENT CPC | Peptides C07K 16/30 (20130101) C07K 16/2809 (20130101) C07K 2317/31 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6857 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176558 | Mhatre et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Anand Ashok Mhatre (Columbus, Ohio); Jonathan L. Pearlman (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system for monitoring a condition of a mobility system includes a number of sensors coupled to the mobility system, the number of sensors being structured and configured to generate data indicative of use of the mobility system during use, and a controller implementing a trained machine learning system. The controller is structured and configured to receive the data, characterize a lifecycle stage of the mobility system using the trained machine learning system based on at least the received data, and generate an alert for required maintenance for and/or predicted breakdown of the mobility system based on the characterized lifecycle stage. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/933616 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/10 (20130101) A61G 2203/36 (20130101) A61G 2203/46 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 23/027 (20130101) G05B 23/0243 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178173 | Kaazempur-Mofrad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad R. Kaazempur-Mofrad (Lafayette, California); Mohammad Soheilypour (Danville, California) |
| ABSTRACT | Methods and systems are provided for simulating metabolic interactions between a microbiome and a chemical compound. In one embodiment, a method includes predicting, with a trained deep neural network, a plurality of enzymes potentially responsible for metabolism of a chemical compound, generating a three-dimensional individual-specific model of a microbiome including one or more microorganisms associated with the plurality of enzymes, and simulating, with the three-dimensional individual-specific model, metabolism of the chemical compound in the microbiome over time. In this way, the individual-specific metabolism of chemical compounds, such as drug compounds, in microbiomes, such as human gut microbiomes, may be reliably predicted in a high-throughput fashion while accounting for three-dimensional compound structure. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/995250 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 15/30 (20190201) Original (OR) Class G16B 40/20 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178179 | Ekim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baris Ekim (Somerville, Massachusetts); Bonnie Berger Leighton (Newtonville, Massachusetts); Rayan Chikhi (Paris, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baris Ekim (Somerville, Massachusetts); Bonnie Berger Leighton (Newtonville, Massachusetts); Rayan Chikhi (Paris, France) |
| ABSTRACT | A method for computation- and memory-efficient DNA sequencing. In one embodiment, the approach herein is used to facilitate genome assembly for state-of-the-art and low-error long-read data. In this embodiment, the approach herein implements a minimizer-space de Bruijn graph, which—instead of building an assembly over sequence bases (in a base-space wherein an alphabet sequence comprises nucleotide letters)—performs assembly in a minimizer-space (wherein an alphabet sequence comprises an ordered sequence of minimizers), and later converts the assembly back to base-space assemblies. Specifically, and in a preferred implementation, each read is initially converted to an ordered sequence of its minimizers. The order of the minimizers is maintained to facilitate reconstructing the entire genome as an ordered list. To aid in assembly of higher-error rate data, a partial order alignment (POA) algorithm designed to operate in minimizer-space instead of base-space in implemented, and it effectively corrects only the bases corresponding to minimizers in the reads. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903654 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) Original (OR) Class G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178184 | Putnam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dovetail Genomics, LLC (Scotts Valley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas H. Putnam (Waltham, Massachusetts); Jonathan C. Stites (Santa Cruz, California); Brandon J. Rice (Santa Cruz, California) |
| ABSTRACT | Disclosed herein are compositions, systems and methods related to sequence assembly, such as nucleic acid sequence assembly of single reads and contigs into larger contigs and scaffolds through the use of read pair sequence information, such as read pair information indicative of nucleic acid sequence phase or physical linkage. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/163421 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 30/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178187 | Gurcan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Metin Gurcan (Winston-Salem, North Carolina); Caglar Senaras (Eindhoven, Netherlands); Gerard Lozanski (West Dublin, Ohio) |
| ABSTRACT | Disclosed herein are systems, methods and computer-program products to create synthetic immunohistochemistry (IHC) stained digital slides generated using artificial neural networks (ANNs). In some implementations, the created digital slides can be used as a ground truth to evaluate a method of analyzing IHC stained tissues. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/104662 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) Computer Systems Based on Specific Computational Models G06N 3/045 (20230101) G06N 3/088 (20130101) G06N 20/20 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/30 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178218 | Papaioannou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vasileios K. Papaioannou (Baltimore, Maryland); Quan Chen (Lexington, Kentucky); Xue Feng (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vasileios K. Papaioannou (Baltimore, Maryland); Quan Chen (Lexington, Kentucky); Xue Feng (Lexington, Kentucky) |
| ABSTRACT | The present disclosure relates to a method and apparatus for robust and automatic face de-identification from CT and MRI. The method includes: receiving DICOM files of patient bodies obtained by a CT or MM system; normalizing the images; extracting the heads from bodies; creating face masks; and writing DICOM files back with de-identified faces. |
| FILED | Saturday, December 04, 2021 |
| APPL NO | 17/542409 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) Original (OR) Class G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178243 | Wilmanski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Institute for Systems Biology (Seattle, Washington) |
| ASSIGNEE(S) | Institute for Systems Biology (Seattle, Washington) |
| INVENTOR(S) | Tomasz Wilmanski (Seattle, Washington); Noa Rappaport (Bellevue, Washington); Andrew T. Magis (Seattle, Washington); Sean M. Gibbons (Seattle, Washington) |
| ABSTRACT | Predicting therapy from gut compositional data is described herein. In an example, a system accesses gut compositional data including a taxonomic abundance, a taxonomic diversity, and/or an enterotype for a subject. The system generates a gut microbiome signature for a safety and an efficacy of a statin therapy for the subject by applying a classifier to the gut compositional data. The safety of the statin therapy is characterized by an insulin resistance of the subject and the efficacy of the statin therapy is characterized by a blood hydroxymethylglutarate level of the subject. The system determines a recommended therapy for the subject based on the gut microbiome signature and one or more taxa of the gut compositional data of the subject. The recommended therapy is selected from a statin therapy intensity, a probiotic therapy, a prebiotic therapy, or a combination thereof. The system outputs the recommended therapy. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160678 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 40/67 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178350 | HUNT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia); THERMO FINNIGAN LLC (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald F. HUNT (Charlottesville, Virginia); Ann M. ENGLISH (Andover, Massachusetts); Scott A. UGRIN (Charlottesville, Virginia); Dina L. BAI (Charlottesville, Virginia); Jeffrey SHABANOWITZ (Charlottesville, Virginia); John Edward Philip SYKA (Charlottesville, Virginia) |
| ABSTRACT | The present disclosure relates to novel and improved methods of analyzing proteins, peptides and polypeptides by mass spectrometry using ion-ion reactions. More specifically the disclosure relates to improved methods for implementing the m/z selective arresting of ion-ion reactions within the ion-ion reaction cell of a mass spectrometer system during a period where ion-ion reactions are performed. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/063975 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 2560/00 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/04 (20130101) H01J 49/0031 (20130101) H01J 49/0072 (20130101) Original (OR) Class H01J 49/4295 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230172513 | Kuzum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duygu Kuzum (La Jolla, California); Yichen Lu (Richmond, California); Xin Liu (San Diego, California); Jeong-hoon Kim (La Jolla, California) |
| ABSTRACT | Flexible, insertable, transparent microelectrode arrays that allow integration of electrophysiological recordings with any optical imaging or stimulation technology are disclosed. In some embodiments of the disclosed technology, a microelectrode array includes a flexible substrate layer including a shank member extending in a first direction and a tapered tip at an end of the shank member, and a plurality of electrode wires arranged in the first direction on the flexible substrate layer, wherein the plurality of electrode wires includes adjacent electrode wires having different lengths from each other such that an electrode wire arranged closer to a centerline of the flexible substrate layer is longer than an adjacent electrode arranged further away from the centerline of the flexible substrate. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/063040 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0084 (20130101) A61B 5/293 (20210101) Original (OR) Class A61B 2562/04 (20130101) A61B 2562/028 (20130101) A61B 2562/125 (20130101) A61B 2562/164 (20130101) A61B 2562/0209 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 1/008 (20130101) B81B 2201/12 (20130101) B81B 2203/04 (20130101) B81B 2203/0361 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230172917 — Methods of Treating Bone Marrow Failure Syndromes and Compositions for Use in the Same
| US 20230172917 | Sakamoto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathleen Miho Sakamoto (Stanford, California); Mark Wilkes (Stanford, California) |
| ABSTRACT | Methods of treating a subject for a bone marrow failure syndrome, e.g., DBA, are provided. Aspects of the methods include administering to the subject an effective amount of a Nemo-Like Kinase (NLK) inhibitor. Also provided are compositions that find use in practicing embodiment of the invention. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/924601 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/4375 (20130101) Original (OR) Class A61K 36/258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172977 | Beckman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Joseph Beckman (Corvallis, Oregon); James Hurst (Beaverton, Oregon); John Sirois (Corvallis, Oregon); Chris Beaudry (Corvallis, Oregon) |
| ABSTRACT | Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/102474 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/4545 (20130101) A61K 33/34 (20130101) Original (OR) Class A61K 45/06 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173419 | Tour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | James M. Tour (Bellaire, Texas); Michael G. Stanford (Houston, Texas); John Li (Houston, Texas); Yieu Chyan (Houston, Texas); Christopher John Arnusch (Midreshet Ben-Gurion, Israel); Steven E. Presutti (Houston, Texas) |
| ABSTRACT | Virus and microbe-killing, self-sterilizing resistive heated air filters and methods of making and using same methods. The air filter is includes laser-induced graphene (LIG), a porous conductive graphene foam formed through photothermal conversion of a polyimide film (or another source or source of polymer or other LIG precursor material) by a laser source. The LIG in the air filter can capture particulates and bacteria. The bacteria cannot proliferate even when submerged in culture medium. Through a periodic Joule-heating mechanism, the filter easily reaches greater than 300° C. This destroys any microorganisms including bacteria, along with molecules that can cause adverse biological reactions and diseases such as viruses, pyrogens, allergens, exotoxins, endotoxins, teichoic acids, mycotoxins, nucleic acids, and prions |
| FILED | Monday, August 10, 2020 |
| APPL NO | 16/969131 |
| CURRENT CPC | Separation B01D 39/2055 (20130101) Original (OR) Class B01D 46/0001 (20130101) B01D 46/48 (20130101) B01D 46/84 (20220101) B01D 46/785 (20220101) B01D 2201/088 (20130101) B01D 2221/10 (20130101) B01D 2279/65 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173449 | De Rutte et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Joseph De Rutte (Los Angeles, California); Dino Di Carlo (Los Angeles, California); Sohyung Lee (Los Angeles, California) |
| ABSTRACT | A method of fabricating shaped particles is disclosed. The method involves generating a plurality of droplets within dispersion media (e.g., oil and surfactant), the plurality of droplets formed from a mixture of precursor materials that are in a miscible state. A stimulus or change of conditions is then introduced to the droplets so as to cause the mixture of precursor materials to become immiscible and phase-separate from one another. The phase-separated droplets are then crosslinked to form shaped particles. The stimulus or change of conditions may include one or more of the following: a change in temperature, a change in pH, a change in osmolarity, a change composition of the droplets, a change in the composition of the dispersion media. The shaped particles may be washed to remove un-crosslinked material and one or more affinity capture agents may be immobilized onto the shaped particles. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/996927 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/14 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/585 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173711 | Sonkusale |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sameer Sonkusale (Lincoln, Massachusetts) |
| ABSTRACT | In an apparatus for manufacturing a coated thread, a thread extends between first and second spools and passes through a cartridge having ink reservoirs in which the stretched thread is dipped while the thread and a sensor that provides, to a controller, a value of a parameter indicative of an extent to which the thread has been dipped in the ink reservoir. The controller uses this parameter as a basis for controlling rotation of a motor that rotates one of the spools. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/916294 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 15/125 (20130101) Original (OR) Class Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/36 (20130101) D02G 3/404 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174254 | Youtsey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MICROLINK DEVICES, INC. (Niles, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Youtsey (Libertyville, Illinois); Mark Osowski (Vernon Hills, Illinois); Rao Tatavarti (Mount Prospect, Illinois) |
| ABSTRACT | Systems and methods are presented including solar cells or solar sheets having textured coversheets that provide increased light collection efficiency. Some embodiments include a textured solar sheet configured for installation on a surface of a UAV or on a surface of a component of a UAV. The textured solar sheet includes a plurality of solar cells and a polymer layer to which the plurality of solar cells are attached. Some embodiments include a kit for supplying solar power in a battery-powered or fuel cell powered unmanned aerial vehicle (UAV) by incorporating flexible, textured solar cells into a component of a UAV, affixing flexible, textured solar cells to a surface of a UAV, or affixing flexible, textured solar cells to a surface of a component of a UAV. The kit also includes a power conditioning system configured to operate the solar cells within a desired power range and configured to provide power having a voltage compatible with an electrical system of the UAV. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/962101 |
| CURRENT CPC | Unmanned aerial vehicles [UAV]; equipment therefor B64U 30/10 (20230101) B64U 50/31 (20230101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0543 (20141201) H01L 31/03926 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174434 | Kovacs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. Kovacs (Columbus, Ohio); Timothy J. Haugan (Dayton, Ohio) |
| ABSTRACT | The present invention relates to a metal-halide composite, articles comprising a metal-halide composite and method of making and using same. The metal-halide matrix materials used in such composite have the desired properties of high thermal conductivity, resistance to thermal induced microstructural changes, and ease of use. As a result, they permit the fabrication of higher performance cryogenic magnets, motors, generators, and cables. Additionally, they permit the fabrication of plate reinforced composites that are useful in lightweight armor and other articles. Additionally, an optoelectronic composite could be built depending on the choice of metal-halide matrix and reinforcement. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 17/988845 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/82 (20130101) Original (OR) Class C04B 35/657 (20130101) C04B 35/6269 (20130101) C04B 35/62881 (20130101) C04B 35/62886 (20130101) C04B 2235/444 (20130101) C04B 2235/522 (20130101) C04B 2235/616 (20130101) C04B 2235/5256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174510 | Iuvone et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Michael Iuvone (Decatur, Georgia); Frank Edward McDonald (Tucker, Georgia); Christopher Lee Walker (Loganville, Georgia) |
| ABSTRACT | This disclosure relates to N-acetylserotonin derivatives that have neuroprotective properties for uses in treating or preventing traumatic brain injury, vision loss, neuronal cell ischemia, and retinal degenerative diseases. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising the N-acetylserotonin derivative and a pharmaceutically acceptable excipient. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/922131 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174563 | Chaloux et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian L. Chaloux (Washington, District of Columbia); Andrew P. Purdy (Washington, District of Columbia); Albert Epshteyn (Washington, District of Columbia) |
| ABSTRACT | Cyanophosphines other than P(CN)3 react with lithium dicyanamide to produce lithiated carbon phosphonitrides with mobile Li+ ions. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/983662 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/5036 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174572 | Thomas, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Dale Arlington Thomas, III (Hampden, Maine); Alexander James Mijalis (Shreveport, Louisiana); Bradley L. Pentelute (Cambridge, Massachusetts); Mark David Simon (Boston, Massachusetts); Andrea Adamo (Cambridge, Massachusetts); Patrick Louis Heider (Midland, Michigan); Klavs F. Jensen (Lexington, Massachusetts) |
| ABSTRACT | Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 17/747952 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/24 (20130101) B01J 2219/24 (20130101) Peptides C07K 1/045 (20130101) C07K 1/084 (20130101) Original (OR) Class C07K 7/06 (20130101) C07K 14/47 (20130101) C07K 14/60 (20130101) C07K 14/61 (20130101) C07K 14/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174595 | Matoba |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nobuyuki Matoba (Owensboro, Kentucky) |
| ABSTRACT | Polypeptides are provided that include an actinohivin variant polypeptide. The actinohivin variant polypeptide can be operably connected to an antibody fragment, such as a fragment crystallizable (Fc) region of immunoglobulin (Ig) G. Nucleic acid sequences, expression vectors, and transformed plant cells useful for producing the polypeptides are also provided. Further provided are methods for treating a viral infection or a cancer in a subject and include the step of administering the actinohivin variant polypeptide to the subject. |
| FILED | Friday, February 09, 2018 |
| APPL NO | 16/485021 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 11/00 (20180101) A61P 31/18 (20180101) A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 14/36 (20130101) Original (OR) Class C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174612 | ROYBAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kole T. ROYBAL (San Francisco, California); Iowis ZHU (San Francisco, California); Raymond LIU (San Francisco, California); Ahmad S. KHALIL (Boston, Massachusetts); Divya ISRANI (Boston, Massachusetts) |
| ABSTRACT | The present disclosure generally relates to, inter alia, a new class of chimeric Notch receptors containing a synthetic zinc finger transcriptional effector (synZTE) module, engineered to modulate gene expression and cellular activities in a ligand-dependent manner. The new Notch receptors surprisingly retain the ability to transduce signals in response to ligand binding despite that the Notch extracellular subunit (NEC), which includes the negative regulatory region (NRR) previously believed to be essential for the functioning of Notch receptors, is partly or completely deleted. In addition, the synZTE is designed to bind orthogonal DNA target sequences in target organisms which in turn facilitates precise regulation of therapeutic gene expression with minimal off-target activity. Also provided are compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/995765 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class C07K 14/70517 (20130101) C07K 16/2803 (20130101) C07K 2317/24 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/035 (20130101) C07K 2319/81 (20130101) C07K 2319/715 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174627 | FROUDE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jeffrey W. FROUDE (Walkersville, Maryland); John M. DYE (Frederick, Maryland); Andrew S. HERBERT (Frederick, Maryland); Philippe THULLIER (Frederick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey W. FROUDE (Walkersville, Maryland); John M. DYE (Frederick, Maryland); Andrew S. HERBERT (Frederick, Maryland); Philippe THULLIER (Frederick, Maryland) |
| ABSTRACT | Formulations and methods of treatment for a patient infected with Sudan vims are provided. The formulation comprises a therapeutically effective combination of: (i). a first monoclonal antibody comprising a heavy chain variable region comprising an amino acid sequence deduced from the nucleic acid molecule as set forth in SEQ. ID NO: 5, and a light chain variable region comprising an amino acid sequence deduced from the nucleic acid molecule as set forth in SEQ ID NO: 6, therapeutically effective mutations, and humanized variants thereof, and humanized variants thereof; (ii). a second monoclonal antibody comprising a heavy chain variable region comprising an amino acid sequence deduced from the nucleic acid molecule as set forth in SEQ. ID NO: 13 and a light chain variable region comprising an amino acid sequence deduced from the nucleic acid molecule as set forth in SEQ ID NO: 14, therapeutically effective mutations, and humanized variants thereof. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/611391 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174858 | Frontiera et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renee Frontiera (Minneapolis, Minnesota); Jill Millstone (Pittsburgh, Pennsylvania); Chris Warkentin (Minneapolis, Minnesota); Xing Yee Gan (Pittsburgh, Pennsylvania); Emily Keller (Minneapolis, Minnesota) |
| ABSTRACT | A device includes chalcogenide nanoparticles and a light-sensitive material configured to absorb upconverted light generated by the chalcogenide nanoparticles. A method includes receiving, at chalcogenide nanoparticles, input light having a first wavelength; and upconverting the input light using the chalcogenide nanoparticles, to generate output light having a second wavelength, in which the second wavelength is less than the first wavelength. A device includes a transparent material, the transparent material being transparent to at least one of infrared light and visible light, and chalcogenide nanoparticles embedded in the transparent material. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/923824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5115 (20130101) A61K 41/0057 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/02 (20130101) C09K 11/881 (20130101) Original (OR) Class Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/209 (20130101) H01G 9/2009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/055 (20130101) Organic electric solid-state devices H10K 30/35 (20230201) H10K 30/87 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174953 | VIGNUZZI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INSTITUT PASTEUR (PARIS CEDEX 15, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MARCO VIGNUZZI (Paris, France); BJORN MEYER (Paris, France); VERONICA REZELJ (Paris, France); LAURA LEVI (Paris, France); VERONIKA BERNHAUEROVA (Paris, France); THOMAS VALLET (Paris, France); TANGUY PIEPLU (Paris, France); DJOSHKUN SHENGJULER (Paris, France); STEPHANIE BEAUCOURT (Paris, France); HERVE BLANC (Paris, France); NATHALIE PARDIGON (Paris, France); GIOVANNA BARBA-SPAETH (Paris, France); MARIA-CARLA SALEH (Paris, France) |
| ABSTRACT | Method for producing a defective interfering viral genome (DVG), defective interfering particles comprising the DVG, and methods and uses thereof. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/907424 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2770/20021 (20130101) C12N 2770/20034 (20130101) C12N 2770/32321 (20130101) C12N 2770/32334 (20130101) C12N 2770/32721 (20130101) C12N 2770/32734 (20130101) C12N 2770/36121 (20130101) C12N 2770/36134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174975 | Qi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Lei S. Qi (Stanford, California); Marie F. LA RUSSA (Stanford, California); Timothy R. ABBOTT (Stanford, California); David B. LEWIS (Stanford, California) |
| ABSTRACT | Described herein are systems for targeting viral genomes. Also described herein are methods for targeting viral genomes utilizing the systems described in the instant disclosure. In some cases, systems and methods disclosed herein can be used to treat viral infections. In preferred embodiments, the systems utilise a CRISPR/Cas13d complex to target the genome of an RNA virus such as coronavirus or influenza virus. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/911079 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2320/31 (20130101) C12N 2740/15043 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175023 | Tracewell et al. |
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| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cara Ann Tracewell (Walnut Creek, California); Alexander Glennon Shearer (San Francisco, California); Anupam Chowdhury (Emeryville, California) |
| ABSTRACT | The present disclosure describes the engineering of microbial cells for fermentative production of 3,4-dihydroxybenzoic acid and provides novel engineered microbial cells and cultures, as well as related 3,4-dihydroxybenzoic acid production methods. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/917221 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 9/1022 (20130101) C12N 9/1085 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class Enzymes C12Y 202/01002 (20130101) C12Y 205/01054 (20130101) C12Y 402/0101 (20130101) C12Y 402/01011 (20130101) C12Y 402/01118 (20130101) C12Y 402/03004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175069 | WANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEAL TH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaosong WANG (Sewickley, Pennsylvania) |
| ABSTRACT | Disclosed herein are compositions and methods for detecting ESR1/CCDC170 gene fusions relating to cancer. Also disclosed herein are compositions and methods for diagnosing and treating cancers that include detecting an ESR1/CCDC170 gene fusion. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/922027 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 14/721 (20130101) C07K 14/4738 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175118 | Kummel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California, a California (Oakland, California); Merck Patent GmbH (Darmstadt, Germany); Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Kummel (San Diego, California); Cheng-Hsuan Kuo (San Diego, California); SeongUk Yun (Carlsbad, California); Ravindra Kanjolia (North Andover, Massachusetts); Mansour Moinpour (San Jose, California); Daniel Moser (Manitowoc, Wisconsin) |
| ABSTRACT | A method of forming a conformal layer including TiN in a via includes introducing a precursor into a reaction chamber according to a first exposure schedule. The precursor includes non-halogenated metal-organic titanium. The first exposure schedule indicates precursor exposure periods. Each precursor exposure period is associated with a particular duration of time and a particular duty cycle over which to introduce the precursor during the particular duration of time. The method includes introducing a co-reactant into the reaction chamber according to a second exposure schedule. The co-reactant includes nitrogen. The second exposure schedule indicates co-reactant exposure periods. Each co-reactant exposure period is associated with a particular duration of time and a particular duty cycle over which to introduce the co-reactant during the particular duration of time. The method includes providing the conformal layer including TiN in the via based on said introducing the precursor and the co-reactant. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/062274 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/34 (20130101) C23C 16/045 (20130101) Original (OR) Class C23C 16/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175133 | Kummel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Merck Patent GmbH (Darmstadt, Germany); Samsung Electronics Co., Ltd. (Suwon-si, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Kummel (San Diego, California); Michael Breeden (La Jolla, California); Victor Wang (Whittier, California); Ravindra Kanjolia (North Andover, Massachusetts); Mansour Moinpour (San Jose, California); Harsono Simka (Saratoga, California) |
| ABSTRACT | Described are low resistivity metal layers/films, such as low resistivity ruthenium (Ru) layers/films, and methods of forming low resistivity metal films. Ru layers/films with close-to-bulk resistivity can be prepared on substrates using Ru(CpEt)2 + O2 ALD, as well as a two-step ALD process using Ru(DMBD)(CO)3 + TBA (tertiary butyl amine) to nucleate the substrate and Ru(EtCp)2 + O2 to increase layer/film thickness. The Ru layer/films and methods of preparing Ru layers/films described herein may be suitable for use in barrierless via-fills, as well as at M0/M1 interconnect layers. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/062502 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/18 (20130101) C23C 16/56 (20130101) C23C 16/45553 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/28568 (20130101) H01L 23/5226 (20130101) H01L 23/53209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175158 | CHOI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the Stevens Institute of Technology (Hoboken, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| INVENTOR(S) | Chang-Hwan CHOI (Tenafly, New Jersey); Junghoon LEE (Busan, South Korea) |
| ABSTRACT | A method for creating oil-filled porous anodic oxide coatings for metallic surfaces is disclosed. The coating has anti-corrosion and omniphobic properties to resist both underwater and atmospheric conditions. To realize oil-impregnated three-dimensional bottle-shaped pores in the oxide layer in anodizing aluminum, the following steps may be taken. First, the target surface may be cleaned and electropolished. Then, a first anodizing step at a lower voltage is applied to create relatively small-diameter pores in the entrance (i.e., top) region of the oxide layer, followed by a second anodizing step at a higher voltage to subsequently create larger-diameter pores in the base (i.e., bottom) region of the oxide layer. Pore widening follows to enlarge the overall pore diameters. To fill the porous coating with an oil, a solvent exchange method may be utilized. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 17/976614 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 11/18 (20130101) C25D 11/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175408 | Heeter et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Heeter (Noblesville, Indiana); Daniel E. Molnar, JR. (Lebanon, Indiana) |
| ABSTRACT | A guide vane assembly includes a fan case, a vane, and a retention ring. The fan case extends circumferentially partway about an axis. The vane extends radially inward away from the fan case and is coupled to the fan case. The retention ring extends circumferentially partway about the axis and is coupled with the fan case and supports the vane. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/541752 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/042 (20130101) Original (OR) Class F01D 25/246 (20130101) Jet-propulsion Plants F02K 3/06 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2230/60 (20130101) F05D 2240/12 (20130101) F05D 2240/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175922 | Crotser et al. |
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| FUNDED BY |
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| APPLICANT(S) | Redwire Holdings, LLC (Jacksonville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dave Crotser (Longmont, Colorado); Heather Passe (Boulder, Colorado); Lee Peterson (Placitas, New Mexico) |
| ABSTRACT | The present disclosure provides for systems and methods for quasi-static and dynamic characterization and adjustment of radio frequency aperture and transmission. The system may comprise a transmission structure with a plurality of sensors. The system may comprise a plurality of optical metric markers. The system may receive corrective signals, shape, or deflection knowledge, or any combination thereof, from an estimator to one or more controllers. The method may comprise association of distance measurements received from a plurality of sensors through physical system identification to plot cartesian coordinates in three-dimensional space as a function of time. When the system comprises one or more controllers, the controllers may be actuated in response to shape or deformation knowledge provided by the computation module. The estimator may comprise phase correction of a large array from sparse data that is then translated to controller actuation. |
| FILED | Saturday, November 05, 2022 |
| APPL NO | 17/981417 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/16 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/3172 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4808 (20130101) G01S 17/89 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176003 | Cao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brewer Science, Inc. (Rolla, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xi Cao (Tracy, California); Christopher Landorf (Springfield, Missouri); Jonathan J. Fury (Springfield, Missouri); Cody Simmons (Springfield, Missouri); Weston Bowen (Springfield, Missouri) |
| ABSTRACT | Composites comprising metal-oxide-functionalized carbon nanotubes with metal nanoparticles deposited thereon are provided. These composites can be used as a working electrode in an electrochemical sensor to detect arsenite in aqueous solutions. The composite can electrochemically reduce As3+ to As0 due to increasing adsorption capability. In one embodiment, Au nanoparticles are deposited on the TiOx/CNT electrode to facilitate the adsorption of As3+ on the electrode surface for further electrochemical reduction process. Square wave voltammetry (SWV) is performed to detect the electrochemical reduction of arsenite in water. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856687 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/301 (20130101) Original (OR) Class G01N 27/333 (20130101) G01N 33/1813 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176072 | ZHOU et al. |
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| FUNDED BY |
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| APPLICANT(S) | Zymeron Corporation (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan ZHOU (Durham, North Carolina); Zhiguo ZHOU (Durham, North Carolina); Qian LI (Durham, North Carolina) |
| ABSTRACT | An immunoassay platform and methodology are described for discriminatively detecting target microorganism antibodies to a target antigen in a biological sample derived from a host animal, from among antibodies of cross-reactively-related microorganism(s) potentially present in the biological sample, by use of contemporaneous assays conducted with and without blocking antibodies exogenous to the host animal. Attenuation of detection reagent signal between the contemporaneous assays may be used to determine a target antigen previously infected or non-infected status of the host animal. An assay system is described, including: a single-use cartridge containing test strips constituted to perform the immunoassay; an integrated sample collection and processing device engageable with the single-use cartridge for delivery of sample thereto, and for operatively initiating immunoassay performance in the single-use cartridge; and a portable immunoassay reader for reading immunoassay output signals from the test strips of the single-use cartridge. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/541065 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/6887 (20130101) Original (OR) Class G01N 33/54306 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176073 | YOHANNES et al. |
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| FUNDED BY |
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| APPLICANT(S) | Government of The United States, As Represented By The Secretary of The Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth H. YOHANNES (University Place, Washington); Avedis A. KAZANJIAN (Olympia, Washington); Richard O. BURNEY (University Place, Washington) |
| ABSTRACT | A method including detecting a presence of at least one analyte in a sample from a subject wherein the at least one analyte is selected from the group consisting of: mesothelin, Galectin-3-binding protein, Clusterin, Polymeric immunoglobulin receptor, Neutrophil gelatinase-associated lipocalin, Leucine-rich alpha-2-glycoprotein, Osteopontin, Alpha-amylase 1, WAP four-disulfide core domain protein 2, Mucin-16, GSTP1, PRDX5, TXN, PRDX6, and SOD1, and determining the subject has hydrosalpinx if the sample comprises an increased level of mesothelin, Galectin-3-binding protein, Clusterin, Polymeric immunoglobulin receptor, Neutrophil gelatinase-associated lipocalin, Leucine-rich alpha-2-glycoprotein, Osteopontin, Alpha-amylase 1, WAP four-disulfide core domain protein 2, and/or Mucin-16 relative to a control, and/or a decreased level of GSTP1, PRDX5, TXN, PRDX6, and/or SOD1, relative to the control, is provided herein. The method may further include if the subject is determined to have hydrosalpinx, administering a hydrosalpinx therapy to the subject. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879330 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2333/46 (20130101) G01N 2333/4704 (20130101) G01N 2333/90283 (20130101) G01N 2333/91177 (20130101) G01N 2800/367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176095 | Ashokkumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Infineon Technologies LLC (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jayant Ashokkumar (Colorado Springs, Colorado); Gregory W. Pauls (San Jose, California) |
| ABSTRACT | In accordance with an embodiment, a circuit includes a plurality of comparators disposed on an integrated circuit, the plurality of comparators having inputs coupled to a monitored power supply line; and a voting circuit having inputs coupled to outputs of the plurality of comparators. An output of the voting circuit is configured to provide a signal indicative of a brown out condition of a power source coupled to the monitored power supply line. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/654482 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 19/16566 (20130101) Original (OR) Class Pulse Technique H03K 19/0021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176119 | Bohman, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Carl Bohman, JR. (Springfield, Ohio); Aaron Jennings (Miamisburg, Ohio); Christian Eakins (Columbus, Ohio); Mark Skouson (Beavercreek, Ohio); Richard Ott (Dayton, Ohio) |
| ABSTRACT | Methods and systems for authenticating electronic devices via multi tone analysis. A method for authenticating a device under test (DUT) of a type of DUT includes imparting voltage tones to the DUT. The voltage tones are proximate a frequency of interest that is associated with the type of DUT. Using a measurement response of the DUT to the voltage tones, an electronic signature of the DUT is determined. The DUT is determined to be authentic when the electronic signature of the DUT substantially matches an electronic signature of an authority DUT of the type of DUT. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/063060 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2837 (20130101) G01R 31/2841 (20130101) G01R 31/31719 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176158 | KARUNASIRI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gamani KARUNASIRI (Pacific Grove, California); Fabio Durante Pereira ALVES (Marina, California) |
| ABSTRACT | A microelectromechanical system configured to be submerged in a fluid having an acoustic sensor assembly having a substrate, interdigitated comb finger capacitors, one or more sensor, a boot assembly a boot assembly having a cavity being configured to contain dielectric fluid and to enclose the acoustic sensor assembly, where the acoustic sensor assembly is communicably coupled to the dielectric fluid and boot, the acoustic sensor assembly being configured to receive the one or more sound waves from a source through the boot and dielectric fluid with near unity acoustic transmission, and a flange assembly disposed at a top side of the boot assembly and configured to cover and seal the acoustic sensor assembly and the dielectric fluid in the boot assembly. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496674 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 3/801 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176176 | Sarma |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Ashwin Sarma (East Greenwich, Rhode Island) |
| ABSTRACT | A method is provided for localizing an underwater vehicle using acoustic ranging. The method includes receiving, using an acoustic receiver, a time series signal based on one or more acoustic signals transmitted from an acoustic source having a known location; determining a travel time of the waveform from the known location of the acoustic source to the acoustic receiver; and determining a range of the underwater vehicle with respect to the acoustic source based on the travel time of the waveform and a sound speed field taken along a ray trajectory extending from the known location of the acoustic source and intersecting with the acoustic receiver at an expected arrival time and depth of the acoustic signal at the underwater vehicle. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539790 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176604 | Zonte |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Infineon Technologies LLC (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cristinel Zonte (Colorado Springs, Colorado) |
| ABSTRACT | In accordance with an embodiment, a circuit includes: a trimmable reference current generator having a temperature dependent current output node, the trimmable reference current generator including: a proportional to absolute temperature (PTAT) current generation circuit; a first programmable current scaling circuit coupled to the PTAT current generation circuit and including a first output coupled to the temperature dependent current output node; a constant current generation circuit; a second programmable current scaling circuit coupled to the constant current generation circuit and including a first output coupled to the temperature dependent current output node; and a reference interface circuit having an input coupled to the temperature dependent current output node and an output configured to be coupled to a reference current input of a memory sense amplifier. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/653409 |
| CURRENT CPC | Systems for Regulating Electric or Magnetic Variables G05F 3/265 (20130101) Original (OR) Class Static Stores G11C 16/26 (20130101) G11C 16/30 (20130101) G11C 16/0466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176939 | Rosenkranz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua M. Rosenkranz (White Plains, New York); Pranita Sharad Dewan (New York, New York); Mudhakar Srivatsa (White Plains, New York); Praveen Jayachandran (Bangalore, India); Chander Govindarajan (Chennai, India); Priyanka Prakash Naik (Mumbai, India); Kavya Govindarajan (Chennai, India) |
| ABSTRACT | An ensemble of autoencoder models can be trained using different seeds. The trained ensemble of autoencoder models can be run on new time series data to generate a prediction associated with the new time series data. The new time series data can include multiple dimensions per time step. Reconstruction errors can be determined for the prediction. Dimensions having highest reconstruction errors can be selected among the multiple dimensions based on a threshold. The prediction can be segmented based on bursts of the reconstruction errors over time, where temporal segments can be obtained. At least one common pattern including a set of dimensions among the selected dimensions across the temporal segments can be obtained to represent a failure fingerprint. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/541453 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/076 (20130101) Original (OR) Class G06F 11/079 (20130101) G06F 11/0709 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230177058 | Ackermann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher F. Ackermann (Fairfax, Virginia); Charles E. Beller (Baltimore, Maryland); Michael Drzewucki (Woodbridge, Virginia) |
| ABSTRACT | The method provides for receiving a plurality of documents including mentions of a target entity from a search query about the entity. The mentions of the target entity are identified in respective documents of the plurality of documents. Content surrounding the one or more mentions of the target entity are extracted with the mentions within the respective documents and form section. A respective document includes a plurality of sections. Metrics of relevance and irrelevance to the target entity are determined within the plurality of sections of the respective documents. A density score is generated for the plurality of sections of the respective documents. A relevancy score is assigned to respective documents of the plurality of documents, based on the density scores of the sections of the respective documents. The documents are ranked based on the relevancy score and presented in an order based on the ranking. |
| FILED | Saturday, December 04, 2021 |
| APPL NO | 17/542412 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/93 (20190101) G06F 16/248 (20190101) G06F 16/24578 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230177323 | Le et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thai F. Le (West Palm Beach, Florida); Supriyo Chakraborty (White Plains, New York) |
| ABSTRACT | A first instance of data and a second instance of data can be received, which have been classified differently. The first instance can be input to a first neural network, the first neural network generating a first encoding associated with the first instance. The second instance can be input to a second neural network the second neural network generating a second encoding associated with the second instance. The first neural network and the second neural network form neural network architecture trained to learn similarities in given pair of input objects. Based on the first encoding and the second encoding, a difference can be identified in features of the first instance and the second instance, which contributed to the first instance and the second instance being classified differently. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545358 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/285 (20190101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178125 | Roy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaushik Roy (West Lafayette, Indiana); Amogh Agrawal (West Lafayette, Indiana); Mustafa Fayez Ahmed Ali (West Lafayette, Indiana); Indranil Chakraborty (West Lafayette, Indiana); Aayush Ankit (West Lafayette, Indiana); Utkarsh Saxena (West Lafayette, None) |
| ABSTRACT | Sparsity-aware reconfiguration compute-in-memory (CIM) static random access memory (SRAM) systems are disclosed. In one aspect, a reconfigurable precision succession approximation register (SAR) analog-to-digital converter (ADC) that has the ability to form (n+m) bit precision using n-bit and m-bit sub-ADCs is provided. By controlling which sub-ADCs are used based on data sparsity, precision may be maintained as needed while providing a more energy efficient design. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/643215 |
| CURRENT CPC | Static Stores G11C 7/16 (20130101) Original (OR) Class G11C 7/109 (20130101) G11C 7/1012 (20130101) G11C 7/1063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178177 | Meeks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); Dxige Research, Inc. (Courtenay, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua J. Meeks (Western Springs, Illinois); Andrew Gordon Robertson (Courtenay, Canada); Aurélien de Reyniès (Paris, France); Clarice S. Groeneveld (Paris, France) |
| ABSTRACT | Disclosed are methods and systems for diagnosing, staging, stratifying, prognosing, and/or treating bladder cancer. In particular, the invention relates to methods and systems for classifying Stage T1 bladder cancer. The disclosed methods may include generating an mRNA expression profile for a sample of Stage T1 bladder cancer and classifying the sample based on the expression profile. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 18/003911 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178448 | Andre et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laura B. Andre (Ann Arbor, Michigan); Long Cheng (Ann Arbor, Michigan); Stephen C. Rand (Ann Arbor, Michigan) |
| ABSTRACT | An illumination source is configured to illuminate a medium with light at a wavelength selected based on an emission band of a selected absorption band of the medium. The selected absorption and emission bands being associated with an electric-dipole-allowed transition of the medium. Upon illumination by the light the medium is cooled. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/073871 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/34 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178667 | Aifer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward H. Aifer (Arlington, Virginia); Jerry R. Meyer (Catonsville, Maryland); Chadwick Lawrence Canedy (Washington, District of Columbia); Igor Vurgaftman (Severna Park, Maryland); Jill A. Nolde (Takoma Park, Maryland) |
| ABSTRACT | An infrared detector and a method for forming it are provided. The detector includes absorber, barrier, and contact regions. The absorber region includes a first semiconductor material, with a first lattice constant, that produces charge carriers in response to infrared light. The barrier region is disposed on the absorber region and comprises a superlatice that includes (i) first barrier region layers comprising the first semiconductor material, and (ii) second barrier region layers comprising a second semiconductor material, different from, but lattice matched to, the first semiconductor material. The first and second barrier region layers are alternatingly arranged. The contact region is disposed on the barrier region and comprises a superlattice that includes (i) first contact region layers comprising the first semiconductor material, and (ii) second contact region layers comprising the second semiconductor material layer. The first and second contact region layers are alternatingly arranged. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879440 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/109 (20130101) H01L 31/1844 (20130101) H01L 31/03046 (20130101) H01L 31/035236 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178809 | Buttry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Daniel Buttry (Tempe, Arizona); Joseph Rheinhardt (Phoenix, Arizona) |
| ABSTRACT | Disclosed is a calcium salt, Ca(HMDS)2, where HMDS is the hexamethyldisilazide anion (also known as bis(trimethylsilyl)amide), enables high current densities and high coulombic efficiency for calcium metal deposition and dissolution. These properties facilitate the use of this salt in batteries based on calcium metal. In addition, the salt is significant for batteries based on metal anodes, which have higher specific energies than batteries based on intercalation anodes, such as LiC6. In particular, a calcium based rechargeable battery includes Ca(HMDS)2 salt and at least one solvent, the solvent suitable for calcium battery cycling. The at least one solvent can be diethyl ether, diisopropylether, methyl t-butyl ether (MTBE), 1,3-dioxane, 1,4-dioxane, tetrahydrofuran (THE), tetrahydropyran, glyme, diglyme, triglyme or tetraglyme, or any mixture thereof. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160423 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/44 (20130101) H01M 10/0565 (20130101) H01M 10/0568 (20130101) Original (OR) Class H01M 10/0569 (20130101) H01M 2300/0025 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179219 | Tantawy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Senseics Corporation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramy Tantawy (Columbus, Ohio) |
| ABSTRACT | An integrated circuit (IC) includes an analog to digital converter (ADC) circuit having an ADC input and an ADC output. The ADC circuit is configured to receive an input signal at the ADC input and generate a digital output signal at the ADC output based on the input signal. An ADC circuit path is coupled between the ADC input and the ADC output. The ADC circuit comprises a plurality of capacitors coupled between reference voltage sources and the ADC circuit path. The ADC has a reconfigurable resolution and a reconfigurable sampling rate. The ADC circuit is configured to scale the reference voltage sources and/or the plurality of capacitors based on the reconfigurable resolution. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/102941 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 1/129 (20130101) H03M 1/442 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179265 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTELLIGENT FUSION TECHNOLOGY, INC. (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhonghai WANG (Germantown, Maryland); Xingping LIN (Germantown, Maryland); Genshe CHEN (Germantown, Maryland); Khanh PHAM (Kirtland AFB, New Mexico); Erik BLASCH (Arlington, Virginia) |
| ABSTRACT | A hidden chamber detector includes a linear frequency modulated continuous wave (LFMCW) radar, a synthetic aperture radar (SAR) imaging processor, and a time division multiple access (TDMA) multiple input multiple output (MIMO) antenna array, including a plurality of transmitting and receiving (Tx-Rx) antenna pairs. A Tx-Rx antenna pair is selected, in a time division manner, as a Tx antenna and an Rx antenna for the LFMCW radar. The LFMCW radar is configured to transmit an illumination signal, receive an echo signal, convert the echo signal to a baseband signal, collect baseband samples, and send the collected samples to the SAR imaging processor. The SAR imaging processor is configured to receive the collected samples, collect structure/configuration of the antenna array and scanning information, and form an SAR image based on the collected samples, the structure/configuration of the antenna array, and the scanning information. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 16/813250 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/354 (20130101) G01S 13/888 (20130101) G01S 13/9017 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179420 | Ramanujan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARCHITECTURE TECHNOLOGY CORPORATION (Eden Prairie, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ranga S. Ramanujan (Medina, Minnesota); Deborah K. Charan (Minneapolis, Minnesota); Barry A. Trent (Chanhassen, Minnesota); Jordan C. Bonney (Bloomington, Minnesota) |
| ABSTRACT | Embodiments for a computer readable medium including a software module are provided. The software module causes one or more processing devices to obtain a biometric identifier from a user. Access to a resource is requested by providing a software credential token and the biometric identifier. The software credential token corresponds to a hardware credential token, and the hardware credential token is one of a set of hardware credential tokens that are used to access the resource. An indication that access to the resource has been granted is received and after receiving the indication an indication that the access to the resource has been revoked is received. After receiving the indication that access to the resource has been revoked, a biometric identifier is re-obtained from a user and access to the resource is re-requested by providing a software credential token and the re-obtained biometric identifier. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/145841 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3213 (20130101) Original (OR) Class H04L 9/3228 (20130101) H04L 9/3234 (20130101) H04L 9/3263 (20130101) H04L 63/083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179434 | Ganji et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | Technische Universitaet Berlin (Berlin, Germany) |
| INVENTOR(S) | Fatemeh Ganji (Gainesville, Florida); Shahin Tajik (Gainesville, Florida); Jean-Pierre Seifert (Werder Havel, Germany); Domenic Forte (Gainesville, Florida); Mark M. Tehranipoor (Gainesville, Florida) |
| ABSTRACT | Combined physical unclonable function (PUFs); methods, apparatuses, systems, and computer program products for enrolling combined PUFs; and methods, apparatuses, systems, and computer program products for authenticating a device physically associated with a combined PUF are described. In an example embodiment, a combined PUF includes a plurality of PUFs and one or more logic gates. Each PUF includes a plurality of stages and an arbiter configured to generate a single PUF response based on response portions generated by the plurality of stages. The one or more logic gates are configured to combine the single PUF response for each of the plurality of PUFs in accordance with a combination function to provide a combined response. |
| FILED | Tuesday, April 07, 2020 |
| APPL NO | 16/841873 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179512 | Drusinsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by The Secretary of The Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Doron Drusinsky (Cupertino, California); James Bret Michael (Pebble Beach, California) |
| ABSTRACT | Methods, and systems, for Multiagent Pathfinding for Non Dynamic Programming Problems, including a CE method which provides for sampling from a complex probability distribution that is not necessarily known in a closed form. The applications of this method include rare-event simulation, variance reduction for estimation problems, and stochastic optimization. The method iteratively searches for a probability distribution that is “close” to the intended distribution, where the closeness of distributions is measured using the Kullback-Liebler (KL) divergence between the distributions. At each step, the method generates samples according to a current candidate distribution from the family. Next, it uses those current candidate distribution samples to move the distribution toward a new candidate distribution that is closer in the sense of KL divergence to the target distribution. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/076807 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/24 (20130101) Original (OR) Class H04L 45/123 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179610 | Rondeau et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher M. Rondeau (Kettering, Ohio); Michael A. Temple (Huber Heights, Ohio); Juan Lopez, JR. (Loudon, Tennessee); J. Addison Betances (Beavercreek, Ohio) |
| ABSTRACT | A method for cyber security monitor includes monitoring a network interface that is inputonly configured to surreptitiously and covertly receive bit-level, physical layer communication between networked control and sensor field devices. During a training mode, a baseline distinct native attribute (DNA) fingerprint is generated for each networked field device. During a protection mode, a current DNA fingerprint is generated for each networked field device. The current DNA fingerprint is compared to the baseline DNA fingerprint for each networked field device. In response to detect at least one of RAA and PAA based on a change in the current DNA fingerprint to the baseline DNA fingerprint of one or more networked field devices, an alert is transmitted, via an external security engine interface to an external security engine, |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106533 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/145 (20130101) H04L 63/0869 (20130101) H04L 63/1416 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179628 | Porras et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Phillip Porras (Menlo Park, California); Kenneth Nitz (Menlo Park, California); Keith Skinner (Menlo Park, California); Dayne Freitag (Menlo Park, California) |
| ABSTRACT | A method of determining an adversarial attack playbook includes receiving, from an adversarial actor, an electronic communication intended for a target user. The method includes engaging in a deep dialog with the adversarial actor by deploying a synthetic persona dynamically during the electronic communication. The deep dialog includes multiple rounds of communication exchanges. The method includes determining a length and type of the deep dialog to obtain attributes related to the adversarial actor. The method includes identifying a conversational pattern from the deep dialog. The conversational pattern comprises dialog interaction elements utilized by the adversarial actor. The method includes dynamically producing, based on the conversational pattern, the playbook associated with the adversarial actor. The playbook is indicative of a dialog interaction strategy implemented by the adversarial actor. The method includes providing the playbook to a social engineering attack (SEA) system in order to detect, avoid and/or mitigate future attacks. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/059496 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/30 (20200101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1483 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230180138 | El-Jamous et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTELLIGENT AUTOMATION, LLC (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ziad El-Jamous (Rockville, Maryland); Yalin Evren Sagduyu (Gaithersburg, Maryland); Kemal Davaslioglu (Ellicott City, Maryland) |
| ABSTRACT | Wireless networks with plural nodes having a respective transceiver and a processor configured to, and methods to, obtain current state data, calculate a reward, store such state data and rewards in a collected parameters database, provide such current state data and data from such collected parameters database to a reinforced neural network, select an action using the reinforced neural network, and output the action to the respective transceiver so as to selective modify its transmit power level. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544649 |
| CURRENT CPC | Wireless Communication Networks H04W 52/06 (20130101) H04W 52/223 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230180609 | Feigelson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Boris N. Feigelson (Springfield, Virginia); Kevin P. Anderson (Arlington, Virginia); Benjamin L. Greenberg (Alexandria, Virginia); James A. Wollmershauser (Alexandria, Virginia); Alan G. Jacobs (Rockville, Maryland) |
| ABSTRACT | Thermoelectric (TE) nanocomposite material that includes at least one component consisting of nanocrystals. A TE nanocomposite material in accordance with the present invention can include, but is not limited to, multiple nanocrystalline structures, nanocrystal networks or partial networks, or multi-component materials, with some components forming connected interpenetrating networks including nanocrystalline networks. The TE nanocomposite material can be in the form of a bulk solid having semiconductor nanocrystallites that form an electrically conductive network within the material. In other embodiments, the TE nanocomposite material can be a nanocomposite thermoelectric material having one network of p-type or n-type semiconductor domains and a low thermal conductivity semiconductor or dielectric network or domains separating the p-type or n-type domains that provides efficient phonon scattering to reduce thermal conductivity while maintaining the electrical properties of the p-type or n-type semiconductor. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061020 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/117 (20130101) C04B 35/488 (20130101) C04B 35/6261 (20130101) C04B 35/62813 (20130101) C04B 35/62823 (20130101) C04B 35/62884 (20130101) C04B 2235/428 (20130101) C04B 2235/614 (20130101) C04B 2235/781 (20130101) C04B 2235/785 (20130101) C04B 2235/3217 (20130101) C04B 2235/3244 (20130101) C04B 2235/5454 (20130101) Electric solid-state devices not otherwise provided for H10N 10/01 (20230201) Original (OR) Class H10N 10/852 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230172189 | Farnoud et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio University (Athens, Ohio) |
| ASSIGNEE(S) | Ohio University (Athens, Ohio) |
| INVENTOR(S) | Amir M. Farnoud (Athens, Ohio); Amid Vahedi (Athens, Ohio) |
| ABSTRACT | Methods for extending the shelf life of donor blood and/or red blood cells (RBC) with a cyclodextrin composition are described. The cyclodextrin composition contains at least one cyclodextrin complexed with at least one exogenous lipid. Also described are such treated donor blood and/or RBC. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/919364 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0226 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0641 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172513 | Kuzum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duygu Kuzum (La Jolla, California); Yichen Lu (Richmond, California); Xin Liu (San Diego, California); Jeong-hoon Kim (La Jolla, California) |
| ABSTRACT | Flexible, insertable, transparent microelectrode arrays that allow integration of electrophysiological recordings with any optical imaging or stimulation technology are disclosed. In some embodiments of the disclosed technology, a microelectrode array includes a flexible substrate layer including a shank member extending in a first direction and a tapered tip at an end of the shank member, and a plurality of electrode wires arranged in the first direction on the flexible substrate layer, wherein the plurality of electrode wires includes adjacent electrode wires having different lengths from each other such that an electrode wire arranged closer to a centerline of the flexible substrate layer is longer than an adjacent electrode arranged further away from the centerline of the flexible substrate. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/063040 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0084 (20130101) A61B 5/293 (20210101) Original (OR) Class A61B 2562/04 (20130101) A61B 2562/028 (20130101) A61B 2562/125 (20130101) A61B 2562/164 (20130101) A61B 2562/0209 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 1/008 (20130101) B81B 2201/12 (20130101) B81B 2203/04 (20130101) B81B 2203/0361 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173144 | Schmidt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christine E. Schmidt (Gainesville, Florida); Scott A. Zawko (Austin, Texas); Sarah M. Mayes (Austin, Texas) |
| ABSTRACT | A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/159756 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/0077 (20130101) A61F 2002/009 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/16 (20130101) A61L 31/041 (20130101) A61L 31/145 (20130101) Original (OR) Class A61L 31/148 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 5/18 (20130101) C08J 2305/04 (20130101) C08J 2405/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173255 | Brooks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin Brooks (Lincoln, Nebraska); Ruiguo Yang (Lincoln, Nebraska); Ikhlaas Mungloo (Lincoln, Nebraska) |
| ABSTRACT | Electroporation devices and methods of making the same. An electroporation device includes a plurality of independently controllable or addressable electrode pairs, a plurality of reaction chambers, each reaction chamber including a first chamber, a second chamber and a porous substrate separating the first chamber from the second chamber, and each reaction chambers being disposed between one of the plurality of independently controllable or addressable electrode pairs, a plurality of first microfluidic channels configured to deliver a cargo solution from a cargo inlet port to the plurality of first chambers, and a plurality of second microfluidic channels configured to deliver a cell culture from a cell inlet port to the plurality of second chambers. In operation, application of a voltage to an electrode pair permeabilizes the membranes of the cells adhered to the porous substrate in the reaction chamber disposed between the electrode pair. |
| FILED | Wednesday, September 21, 2022 |
| APPL NO | 17/933947 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) A61N 1/0408 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173300 | Green |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hadiyah-Nicole Green (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hadiyah-Nicole Green (Atlanta, Georgia) |
| ABSTRACT | Methods, structures, devices and systems are disclosed for implementing a photothermal therapy using nanostructures. In one aspect, a device to produce a photothermal effect includes a particle having a molecular layer functionalized onto the external surface of the particle and structured to attach to one or more targeting molecules capable of binding to a receptor site of a cell, in which the particle is configured to absorb light energy at a particular wavelength to produce a plasmon resonance effect that causes the particle to emit heat energy. In some implementations, the device is deployed in an organism having a tumor that includes a plurality of the cell and binds to the receptor site of the tumor by the targeting molecules, in which the light energy is emitted at a region of the organism that contains the tumor and the heat energy causes cellular death of the tumor cell. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/159860 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 2005/063 (20130101) A61N 2005/0644 (20130101) A61N 2005/0659 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 3/108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173437 | Howarter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | John Alan Howarter (West Lafayette, Indiana); Michael D. Toomey (West Lafayette, Indiana); Logan Kearney (Long Grove, Illinois) |
| ABSTRACT | The separations membrane system includes a substrate, a microporous layer, and a selective layer. The microporous layer may be disposed over the substrate. The selective layer may be disposed over the microporous layer, thereby sandwiching the microporous layer between the selective layer and the substrate. The microporous layer includes a thermoplastic material. The selective layer includes a polyamide structure of 2,2-Dimethyl-1,3-propanediamine and/or 1,3,5-Benzenetricarbonyl chloride. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/075144 |
| CURRENT CPC | Separation B01D 61/025 (20130101) B01D 67/0006 (20130101) B01D 67/0095 (20130101) B01D 69/02 (20130101) B01D 69/1071 (20220801) B01D 69/1216 (20220801) B01D 69/1251 (20220801) B01D 71/56 (20130101) B01D 71/68 (20130101) B01D 71/82 (20130101) Original (OR) Class B01D 2323/36 (20130101) B01D 2323/40 (20130101) B01D 2323/219 (20220801) B01D 2325/04 (20130101) B01D 2325/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173479 | Di Carlo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Dino Di Carlo (Los Angeles, California); Chueh-Yu Wu (Los Angeles, California) |
| ABSTRACT | Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/161322 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0262 (20130101) Original (OR) Class B01L 3/502715 (20130101) B01L 3/502784 (20130101) B01L 2300/021 (20130101) B01L 2300/0816 (20130101) B01L 2300/0877 (20130101) B01L 2300/0896 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/04 (20130101) C12N 5/0625 (20130101) C12N 5/0636 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5432 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173744 | Qui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas); The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | TEXAS TECH UNIVERSITY SYSTEM (Lubbock, Texas); THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| INVENTOR(S) | Jingjing Qui (College Station, Texas); Shiren Wang (College Station, Texas) |
| ABSTRACT | Methods and systems of 3D printing non-photocurable thermosetting polymer materials and continuous fiber composites that reduces the manufacturing time and energy required by implementing fast, self-sustaining, and self-propagating, in-situ curing of the polymer and the and continuous fiber composites as the non-photocurable thermosetting polymer materials are being printed. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/922547 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Original (OR) Class B29C 64/264 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173751 | CORMIER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRISAM LLC (Rochester, New York) |
| ASSIGNEE(S) | PRISAM LLC (Rochester, New York) |
| INVENTOR(S) | DENIS CORMIER (Pittsford, New York); PRITAM PODDAR (Rochester, New York); XAVIER TARR (Rochester, New York); JUSTIN KON (Rochester, New York); ADAM FOSTER (Rochester, New York) |
| ABSTRACT | An apparatus for additive manufacturing having a body; a plurality of articulated arms, each having a jointed connection to the body opposite a free end, the plurality of articulated arms movable relative to each other and the plurality of articulated arms having opposable motions about the jointed connection; an extruder at the free end of each of the plurality of articulated arms, the extruder having an extruder nozzle extending from the free end; and at least one cooling nozzle extending from the free end of each of the plurality of articulated arms. |
| FILED | Monday, September 05, 2022 |
| APPL NO | 17/929721 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/30 (20170801) B29C 64/118 (20170801) B29C 64/209 (20170801) Original (OR) Class B29C 64/227 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174084 | OLSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Edwin OLSON (Ann Arbor, Michigan); Acshi HAGGENMILLER (Ann Arbor, Michigan) |
| ABSTRACT | An uncertainty-aware framework is presented for high-variance planning problems with multiple dynamic agents. Planning when surrounded by multiple uncertain dynamic agents is hard because one cannot be certain of either the initial states or the future actions of those agents, leading to an exponential explosion in possible futures. Many important real-world problems, such as autonomous driving, fit this model. To address these difficulties, Multi-policy Decision Making (MPDM) and Monte Carlo tree search (MCTS) are combined and a policy tree search performed with marginal action cost estimation and repeated belief particles. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/074944 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/143 (20130101) B60W 30/18163 (20130101) B60W 50/06 (20130101) Original (OR) Class B60W 60/0015 (20200201) Electric Digital Data Processing G06F 16/2246 (20190101) G06F 16/2455 (20190101) Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174468 | ISAACS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lyle David ISAACS (Silver Spring, Maryland); Weijian XUE (College Park, Maryland) |
| ABSTRACT | Provided are sulfated pillararenes and methods of making and using same. The pillararenes have macrocycle core having a plurality of aryl groups, attached (e.g., covalently bonded) in a para orientation to the adjacent methylene groups. The pillararenes have a hydrophobic cavity. The hydrophobic cavity may be used to sequester various materials or to deliver materials sequestered therein. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/822863 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) Acyclic or Carbocyclic Compounds C07C 305/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174477 | DAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingji DAI (Alpharetta, Georgia); Hunter SIMS (Decatur, Georgia) |
| ABSTRACT | Methods for the synthesis of a tricyclic-prostaglandin D2 metabolite methyl ester or a pharmaceutically acceptable salt thereof. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/061969 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 405/0075 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174593 | RULLAN-LIND et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PUERTO RICO (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlos Ralph RULLAN-LIND (San Juan, Puerto Rico); Abel Juan BAERGA-ORTIZ (San Juan, Puerto Rico) |
| ABSTRACT | The disclosure provides artificially linked acyl earner proteins that enhance fatty acid biosynthesis and methods for mating the artificially linked acyl earner proteins. The fused dimer comprises acyl carrier proteins and peptide linkers. |
| FILED | Tuesday, August 18, 2020 |
| APPL NO | 17/636470 |
| CURRENT CPC | Peptides C07K 14/28 (20130101) C07K 14/245 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174711 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainsville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen A. Miller (Gainesville, Florida); Olivier Nsengiyumva (Gainesville, Florida) |
| ABSTRACT | In one aspect, the disclosure relates to biorenewable polyesters and polyester copolymers derived from camphoric acid, methods of making same, and articles comprising same. The disclosed biorenewable polyesters can have a Mn of from about 5,000 Da to about 500,000 Da. Also disclosed herein is the preparation of various monomers useful in the reactions disclosed herein, e.g., cis-1,4-anhydroerythritol and bis(2-hydroxyethyl) camphorate. In various aspects, the disclosed biorenewable polyesters and polyester copolymers can be used to the production of various articles utilizing a conventional polyester or polyester copolymer, that is, to replace, in part or in whole, a conventional non-biorenewable polyester or polyester copolymer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089345 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 67/08 (20130101) Heterocyclic Compounds C07D 307/20 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/199 (20130101) Original (OR) Class C08G 2230/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174814 | Dachavaram et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Soma Shekar DACHAVARAM (Little Rock, Arkansas); BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas); Bioventures, LLC (Little Rock, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas); Bioventures, LLC (Little Rock, Arkansas) |
| INVENTOR(S) | Soma Shekar Dachavaram (Little Rock, Arkansas); John P. Moore (Fayetteville, Arkansas); Peter A. Crooks (Little Rock, Arkansas); Jamie Hestekin (Fayetteville, Arkansas) |
| ABSTRACT | A cellulose based anti-viral/anti-microbial coating. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/921955 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) C09D 101/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174864 | Jákli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Antal Jákli (Kent, Ohio); W.S. Kelum Perera (Kent, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antal Jákli (Kent, Ohio); W.S. Kelum Perera (Kent, Ohio) |
| ABSTRACT | The present invention relates to polymer stabilized nematic liquid crystal microlenses. The microlenses can be made from a nematic liquid crystal, a chiral dopant, a reactive monomer, and a photoinitiator. The microlenses can be prepared by spin coating a liquid crystal mixture onto an array including a nickel transmission electron microscope grid. The focal length of the microlens array can be tuned electrically. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/073073 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/14 (20130101) C09K 19/025 (20130101) Original (OR) Class C09K 19/586 (20130101) C09K 19/2021 (20130101) C09K 2019/0407 (20130101) Optical Elements, Systems, or Apparatus G02B 3/14 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0027 (20130101) G02F 1/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175002 | BRADY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siobhan M. BRADY (Davis, California); Alex CANTO-PASTOR (Davis, California); Mona GOURAN (Davis, California); Kaisa KAJALA (Utrecht, Netherlands); Dorota KAWA (Davis, California); Grace Alex MASON (Davis, California); Concepcion MANZANO (Davis, California); Niba NIRMAL (Durham, North Carolina); Lidor SHAAR-MOSHE (Davis, California); Julie BAILEY-SERRES (Riverside, California); Alex BOROWSKY (Riverside, California); Mauricio REYNOSO (Riverside, California); Neelima SINHA (Davis, California) |
| ABSTRACT | The present disclosure provides a list of genes, and the proteins encoded by these genes, that modulate and/or participate in the synthesis of the biopolymer suberin. The genes described here are useful in methods for producing genetically modified plants or breeding plants with altered production (enhanced or disrupted) of suberin. Such plants can contain modified or mutated candidate peptides; or have disrupted expression of using methods such as clustered regularly-interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) nuclease, an antisense nucleic acid, a zinc finger nuclease (ZFN), or a transcription activator-like effector (TALE) nuclease. Suberin has a positive influence on response to plant water stress, a long-lasting role as a carbon sink in soil; and the lack of suberin encourages symbioses for nutrient uptake as well as for prevention of pathogenicity. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/916516 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8243 (20130101) Original (OR) Class C12N 15/8273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175013 | CHATTERJEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON COLLEGE (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhishek CHATTERJEE (Brookline, Massachusetts); Rachel E. KELEMEN (Newton, Massachusetts); Sarah B. ERICKSON (Boston, Massachusetts); Quan PHAM (Chestnut Hill, Massachusetts) |
| ABSTRACT | The present invention discloses platforms for chemically modify AAV capsids with control over site and stoichiometry. An AAV packaging system is described that allows the introduction of site-directed natural and unnatural amino acid mutations into any subset of the three capsid proteins. These engineered residues can be subsequently used to chemically functionalize the resulting capsids with precise control over site and stoichiometry. Such controlled modification strategy can be used to attach a wide variety of entities to AAV capsids to engineer its tropism, immunogenicity, etc. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/922425 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175146 | Kashi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Twelve Benefit Corporation (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ajay R. Kashi (Berkeley, California); Aya K. Buckley (Berkeley, California); Sichao Ma (Dublin, California); Kendra P. Kuhl (Oakland, California); Sara Hunegnaw (Oakland, California); Etosha R. Cave (Berkeley, California); Luka Stevic (Novi Sad, Serbia) |
| ABSTRACT | Systems and methods for increasing the concentration of a desired COx reduction reaction product are described. In some embodiments, the systems and methods include ethylene purification. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063508 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 1/12 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/26 (20210101) Original (OR) Class C25B 9/19 (20210101) C25B 11/075 (20210101) C25B 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230175169 — LOW-DEFECT-DENSITY GAMMA PHASE ALUMINUM OXIDE SUBSTRATES FOR HETEROEPITAXIAL SYNTHESIS
| US 20230175169 | Eom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chang-Beom Eom (Madison, Wisconsin); Rui Liu (Madison, Wisconsin); Paul Gregory Evans (Madison, Wisconsin); Donald E. Savage (Madison, Wisconsin) |
| ABSTRACT | Aluminum oxide (Al2O3) thin films having a high γ-phase purity and low defect density and methods for making the aluminum oxide thin films are provided. Also provided are epitaxial heterostructures that incorporate the aluminum oxide thin films as growth substrates and methods of forming the heterostructures. The Al2O3 films are pure, or nearly pure, γ-Al2O3. As such, the films contain no, or only a very low concentration of, other Al2O3 polymorph phases. In particular, the Al2O3 films contain no, or only a very low concentration of, the θ-Al2O3 polymorph phase. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544298 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/403 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 1/023 (20130101) C30B 29/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175754 | GOLDFARBMUREN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rebound Technologies, Inc. (Commerce City, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RUSSELL GOLDFARBMUREN (Denver, Colorado); LUKE ERICKSON (Denver, Colorado) |
| ABSTRACT | Thermo-chemical recuperation systems, devices, and methods are provided in accordance with various embodiments. Embodiments may generally relate to the field of refrigeration and/or heat pumping. Within that field, some embodiments apply to the recuperation or recapturing of both thermal and chemical potential in a freeze point suppression cycle. Some embodiments include a method and/or system of thermo-chemical recuperation that includes creating a flow of ice and flowing a brine against the flow of the ice. Some embodiments manage the thermal and chemical potentials by mixing a dilute brine stream exiting an ice mixing vessel with an ice stream before it enters the ice mixing vessel. By controlling this mixing in a counter-flow or step-wise cross flow manner with sufficient steps, both the thermal and chemical potential of the dilute bine stream may be recuperated. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/077370 |
| CURRENT CPC | Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 5/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175774 | Yagoobi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jamal S. Yagoobi (Hopkinton, Massachusetts); Mengqiao Yang (Worcester, Massachusetts); Mehrnoosh F. Dardashti (Worcester, Massachusetts) |
| ABSTRACT | An atomizing spray dryer employs one or more stages defined by ultrasonic transducers in close proximity to a liquid feed opening forming a path of an atomization flow for producing uniform droplets from a close tolerance with the transducer. The atomization flow exits a gap between the transducer and an outer edge of the opening, such that the passed liquid is responsive to an oscillation of the transducer for forming the droplets. A conical or other suitably shaped transducer engages a substantially round liquid feed opening. Subsequent stages may include a circular, ring, or other suitable shape aligned to receive the atomization flow from a circumference of the conical base, or may also take any suitable shape, preferably to receive droplets directed by the first stage. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/103794 |
| CURRENT CPC | Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 3/12 (20130101) Original (OR) Class F26B 25/002 (20130101) F26B 2200/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175830 | Clonch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Cameron Clonch (Corvallis, Oregon); Bryson Goto (Corvallis, Oregon); Mark Huynh (Corvallis, Oregon); John Selker (Corvallis, Oregon); Chet Udell (Corvallis, Oregon) |
| ABSTRACT | Described herein is a magnetic dendrometer having a frame, a spring-tension mechanism, and a magnet for moving together with the spring-tension mechanism. A magnetic sensor is attached to the frame. The magnetic sensor senses the linear motion of the magnet. This linear motion translates to trackable fluctuations in magnetic field. The magnetic fluctuations are converted to electrical signals by the magnetic sensor. A spring is attached to a free-floating wishbone-style component. The free-floating wishbone-style component is coupled to a slider which has an adjustable, single-contact point with a target (e.g., a vine, a branch, etc.). The frame is a stationary frame that carries the magnetic sensor. The frame connected via the spring to the wishbone/slider combination cooperates with each other for providing linear motion to extend or contract the spring in length directions. The length variations of the dendrometer spring are converted to linear motion of the magnet and then into electronic signals. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/541151 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 5/025 (20130101) G01B 5/0035 (20130101) G01B 7/12 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175933 | Blauch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lucas R. Blauch (Mountain View, California); Sindy K. Y. Tang (Stanford, California) |
| ABSTRACT | Splitting of biological samples is provided by flowing the samples through a flow splitter where the sample strikes a stationary blade and is split into two pieces that end up in separate output channels. Samples can be single cells or multi-cellular samples. The split ratio of the pieces can be 50:50 or it can be other values as determined by design. To first order, the split ratio of the pieces is the same as the split ratio of the fluid flows in the output channels. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103086 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 2200/027 (20130101) B01L 2200/0605 (20130101) B01L 2200/0647 (20130101) B01L 2300/0864 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175951 | Robles et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francisco E. Robles (Atlanta, Georgia); Wilbur Lam (Atlanta, Georgia); Ashkan Ojaghi (Atlanta, Georgia); Evelyn Williams (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a live cell imaging system, comprising a substrate, a UV light source, and a UV camera. The substrate can have a cavity configured to hold a sample. The sample can comprise one or more live cells. The substrate can be made, at least in part, out of polydimethylsiloxane (PDMS). The UV light source can be configured to direct UV light to the sample. The UV camera can be configured to take a UV image of the sample. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063531 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1463 (20130101) G01N 15/1475 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176004 | Dong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ENGENIOUSAG LLC (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liang Dong (Ames, Iowa); Xinran Wang (Ames, Iowa) |
| ABSTRACT | Provided herein is technology relating to electrochemical detection of analytes and particularly, but not exclusively, to a double junction reference electrode, methods of using a double junction reference electrode, handheld or robotically manipulable apparatuses comprising a double junction reference electrode, and systems comprising a double junction reference electrode. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/074762 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/40 (20130101) G01N 27/301 (20130101) G01N 27/401 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176006 | Gartia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Manas Ranjan Gartia (Baton Rouge, Louisiana); Sushant P. Sahu (Baton Rouge, Louisiana); Christopher G. Arges (Baton Rouge, Louisiana); Deepra Bhattacharya (Baton Rouge, Louisiana); Gokul Venugopalan (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Manas Ranjan Gartia (Baton Rouge, Louisiana); Sushant P. Sahu (Baton Rouge, Louisiana); Christopher G. Arges (Baton Rouge, Louisiana); Deepra Bhattacharya (Baton Rouge, Louisiana); Gokul Venugopalan (Baton Rouge, Louisiana) |
| ABSTRACT | Disclosed herein is a sensor for measuring perfluoroalkyl acids and/or polyfluoroalkyl acids. The sensor includes a working electrode, a counter electrode and optionally a reference electrode. The working electrode includes a film disposed on the surface of the working electrode and the film includes a perfluorinated anion exchange ionomer. A method of using the sensor to detect perfluoroalkyl acids and/or polyfluoroalkyl acids is also described. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/060201 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/301 (20130101) G01N 27/4045 (20130101) G01N 27/4074 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176026 | Urschel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Matthew R. Urschel (Troy, New York); Andrew Turk (Troy, New York); Tessa Hilary Pocock (Troy, New York) |
| ABSTRACT | An apparatus for remote detection of plant growth dynamics is described. The apparatus includes an excitation LED (light emitting diode) module, a detection module and a controller module coupled to the excitation LED module and the detection module. The excitation LED module includes at least one LED. Each LED is configured to emit an excitation light in response to an excitation control signal. The excitation light has an emitted light spectrum. The detection module includes a photodetector configured to detect an initial chlorophyll a fluorescence (“ChlF”) light and an excited ChlF light from a plant species. The photodetector is further configured to convert the detected initial ChlF light into an initial detection electrical signal and the detected excited ChlF light into an excited detection electrical signal. The excited ChlF light is emitted from the plant species in response to receiving the excitation light. The controller module is configured to provide the excitation control signal to the excitation module, to capture the initial and excited detection electrical signals from the detection module and to determine chlorophyll fluorescence data based, at least in part, on the initial and excited detection electrical signals. The excitation LED module and the detection module are configured to be positioned remotely from the plant species. The chlorophyll fluorescence data represents a growth characteristic of the plant species. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944569 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 33/0098 (20130101) Original (OR) Class G01N 2201/062 (20130101) G01N 2201/0696 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176066 | Seth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anushree Seth (St. Louis, Missouri); Jingyi Luan (St. Louis, Missouri); Srikanth Singamaneni (St. Louis, Missouri) |
| ABSTRACT | Described herein are methods and kits for performing plasmon-enhanced fluoro-dot assays. These assays enable observing a correlation between a chemical stimulus and a biological response of cultured cells in vitro. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/061672 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/648 (20130101) G01N 21/6428 (20130101) G01N 33/543 (20130101) G01N 33/582 (20130101) Original (OR) Class G01N 2021/6439 (20130101) G01N 2333/525 (20130101) G01N 2333/5412 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176088 | COE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Angela M. COE (Tenstrike, Minnesota); Guohong LI (Highland, New Jersey); Eva Y. ANDREI (Highland Park, New Jersey) |
| ABSTRACT | An apparatus, including a scanning probe microscope base that includes a configured to be secured to an end of an insert in a cryostat; a top configured to be connected to a base of a scanning probe microscope head that is configured to be disposed inside the insert; and a damping system disposed between the frame and the top and comprising a bellows that seals the end of the insert. This sealing separates an ultra-high vacuum (UHV) environment in the insert from a high vacuum (HV) environment surrounding the end of the insert and also positions an upper surface of the top in the UHV environment. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/996246 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/10 (20130101) G01Q 30/16 (20130101) Original (OR) Class G01Q 30/18 (20130101) G01Q 60/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176558 | Mhatre et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Anand Ashok Mhatre (Columbus, Ohio); Jonathan L. Pearlman (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system for monitoring a condition of a mobility system includes a number of sensors coupled to the mobility system, the number of sensors being structured and configured to generate data indicative of use of the mobility system during use, and a controller implementing a trained machine learning system. The controller is structured and configured to receive the data, characterize a lifecycle stage of the mobility system using the trained machine learning system based on at least the received data, and generate an alert for required maintenance for and/or predicted breakdown of the mobility system based on the characterized lifecycle stage. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/933616 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/10 (20130101) A61G 2203/36 (20130101) A61G 2203/46 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 23/027 (20130101) G05B 23/0243 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230177642 | Kudyshev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Zhaxylyk A. Kudyshev (West Lafayette, Indiana); Demid Sychev (West Lafayette, Indiana); Zachariah Olson Martin (West Lafayette, Indiana); Simeon I. Bogdanov (West Lafayette, Indiana); Xiaohui Xu (West Lafayette, Indiana); Alexander Kildishev (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana); Vladimir Shalaev (West Lafayette, Indiana) |
| ABSTRACT | A method of providing super-resolved images of a photon emitting particle is disclosed, which includes providing a machine-learning (ML) platform, wherein the ML platform is configured to receive pixel-based sparse autocorrelation data and generate a predicted super-resolved image of a photon emitting particle, receiving photons from the photon emitting particle by two or more photon detectors, each generating an electrical pulse associated with receiving an incident photon thereon, generating sparse autocorrelation data from the two or more photon detectors for each pixel within an image area, and inputting the pixel-based sparse autocorrelation data to the ML platform, thereby generating a predicted super-resolved image of the imaging area, wherein the resolution of the super-resolved image is improved by √n as compared to a classical optical microscope limited by Abbe diffraction limit. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858722 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/0072 (20130101) Image Data Processing or Generation, in General G06T 3/4046 (20130101) G06T 3/4053 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179308 | Sen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| INVENTOR(S) | Shreyas Sen (West Lafayette, Indiana); Mayukh Nath (West Lafayette, Indiana); Arunashish Datta (West Lafayette, Indiana) |
| ABSTRACT | A wearable device comprising a transmitter coil having variable transmission resistance, a first transmission impedance, and a second transmission impedance; an implanted device, comprising a receiver coil having a variable reception resistance, a first reception impedance, and a second reception impedance; wherein the transmitter coil can wirelessly transmit information over a variable frequency to the receiver coil when the variable resistance of the transmitter coil is tuned to the variable resistance of the receiver coil, the transmitter coil is configured to the first transmission impedance, and the receiver coil is configured to the first reception impedance; wherein the transmitter coil can wirelessly transmit power to the receiver coil when the transmitter coil is configured to the second transmission impedance and the receiver coil is configured to the second reception impedance; and wherein the transmitter coil can wirelessly transmit to the receiver coil of the implanted device using a magnetoquasistatic field. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/062487 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/37229 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/12 (20160201) Transmission H04B 13/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179434 | Ganji et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | Technische Universitaet Berlin (Berlin, Germany) |
| INVENTOR(S) | Fatemeh Ganji (Gainesville, Florida); Shahin Tajik (Gainesville, Florida); Jean-Pierre Seifert (Werder Havel, Germany); Domenic Forte (Gainesville, Florida); Mark M. Tehranipoor (Gainesville, Florida) |
| ABSTRACT | Combined physical unclonable function (PUFs); methods, apparatuses, systems, and computer program products for enrolling combined PUFs; and methods, apparatuses, systems, and computer program products for authenticating a device physically associated with a combined PUF are described. In an example embodiment, a combined PUF includes a plurality of PUFs and one or more logic gates. Each PUF includes a plurality of stages and an arbiter configured to generate a single PUF response based on response portions generated by the plurality of stages. The one or more logic gates are configured to combine the single PUF response for each of the plurality of PUFs in accordance with a combination function to provide a combined response. |
| FILED | Tuesday, April 07, 2020 |
| APPL NO | 16/841873 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179435 | Heinecke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Blocky, Inc. (Bozeman, Malta) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taylor Heinecke (Bozeman, Montana); David L. Millman (Bozeman, Montana); Mike P. Wittie (Bozeman, Montana) |
| ABSTRACT | A method for creating and maintaining immutability, agreement and availability of data including the steps of building an alternating structure of blocks and timestamp attestations; determining an order of blocks; determining which of the blocks are on a main chain; and using a trusted replication service to replicate all of the blocks, timestamp attestations, sequence attestations, and leaves of the Merkle trees. A computer program product comprising a storage device storing instructions in a non-transitory manner, which instructions cause the computing device to create and maintain immutability, agreement and availability of data according to the foregoing method. A computing device comprising a processing unit, memory or other storage device coupled to the processing unit, the memory or other storage device storage instructions, which cause the computing device to create and maintain immutability, agreement and availability of data according to the foregoing method. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/072574 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/50 (20220501) Original (OR) Class H04L 9/0618 (20130101) H04L 9/3297 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230173426 | Long et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey R. Long (Oakland, California); Phillip J. Milner (Ithaca, New York); Rebecca L. Siegelman (Berkeley, California) |
| ABSTRACT | An adsorption material is disclosed that comprises a metal-organic framework and a plurality of ligands. The metal-organic framework comprising a plurality of metal ions. Each respective ligand in the plurality of ligands is amine appended to a respective metal ion in the plurality of metal ions of the metal-organic framework. Each respective ligand in the plurality of ligands comprises a substituted 1,3-propanediamine. The adsorbent has a CO2 adsorption capacity of greater than 2.50 mmol/g at 150 mbar CO2 at 40° C. Moreover, the adsorbent is configured to regenerate at less than 120° C. An example ligand is diamine 2,2-dimethyl-1,3-propanediamine. An example of the metal-organic framework is Mg2(dobpdc), where dobpdc4− is 4,4′-dioxidobiphenyl-3,3′-dicarboxylate. Example applications for the adsorption material are removal of carbon dioxide from flue gas and biogasses. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937336 |
| CURRENT CPC | Separation B01D 53/02 (20130101) Original (OR) Class B01D 2253/204 (20130101) B01D 2257/504 (20130101) B01D 2258/05 (20130101) B01D 2259/4009 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) B01J 20/3466 (20130101) B01J 20/3491 (20130101) B01J 20/28057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173435 | FRAYNE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Via Separations, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | Via Separations, Inc. (Watertown, Massachusetts) |
| INVENTOR(S) | Stephen FRAYNE (Wayland, Massachusetts); Michelle MACLEOD (Boston, Massachusetts); Brandon Ian MACDONALD (Maynard, Massachusetts); Lymaris ORTIZ RIVERA (Cambridge, Massachusetts); Brent KELLER (Somerville, Massachusetts) |
| ABSTRACT | Embodiments described herein relate generally to durable graphene oxide membranes for fluid filtration. For example, the graphene oxide membranes can be durable under high temperatures non-neutral pH, and/or high pressures. One aspect of the present disclosure relates to a filtration apparatus comprising: a support substrate, and a graphene oxide membrane disposed on the support substrate. The graphene oxide membrane has a first lactose rejection rate of at least 50% with a first 1 wt % lactose solution at room temperature. The graphene oxide membrane has a second lactose rejection rate of at least 50% with a second 1 wt % lactose solution at room temperature after the graphene oxide membrane is contacted with a solution that is at least 80° C. for a period of time. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/960440 |
| CURRENT CPC | Separation B01D 67/0069 (20130101) B01D 67/0093 (20130101) B01D 69/10 (20130101) B01D 71/021 (20130101) Original (OR) Class B01D 2323/36 (20130101) B01D 2325/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173476 | GUNNOE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas B. GUNNOE (Palmyra, Virginia); Benjamin Austin VAUGHAN (Dover, New Hampshire); Michael S. WEBSTER-GARDINER (Mims, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for Rh(I) catalysts, methods of making alkenyl substituted arenes (e.g., allyl arene, vinyl arene, and the like), methods of making alkyl substituted arenes, and the like. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/163647 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/00 (20130101) B01J 31/189 (20130101) B01J 31/1815 (20130101) Original (OR) Class B01J 31/2226 (20130101) B01J 31/2291 (20130101) B01J 2231/46 (20130101) B01J 2531/0244 (20130101) B01J 2531/822 (20130101) B01J 2540/22 (20130101) B01J 2540/225 (20130101) Acyclic or Carbocyclic Compounds C07C 2/66 (20130101) C07C 5/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173501 | Williams et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Benjamin Douglas Williams (Shawnee, Kansas); James Peter Hickson (Overland Park, Kansas); Steven Todd LaPlant (Kansas City, Missouri); Phillip C. Davis (Lee's Summit, Missouri) |
| ABSTRACT | A tool for feeding material into a mill having a roller and forming a nip gap. The tool broadly comprises a baseplate, a guide plate, and a ram. The baseplate is configured to be positioned on the mill over the roller and forms a slot. The guide plate is configured to be positioned in the slot of the baseplate near the nip gap. The guide plate forms a chute for feeding the material into the nip gap. The ram is configured to be inserted into the chute to urge the material into the nip gap while preventing a user's fingers and other foreign objects from nearing the nip gap through the chute. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545955 |
| CURRENT CPC | Crushing, Pulverising, or Disintegrating in General; Milling Grain B02C 4/02 (20130101) B02C 4/286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173579 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheng Zhu (Livermore, California); Eric B. Duoss (Dublin, California); Zhen Qi (Tracy, California); Anthony W. Van Buuren (Livermore, California); Marcus A. Worsley (Hayward, California) |
| ABSTRACT | The production of a porous copper-zinc structure includes providing copper ink, creating a 3D model of the porous copper-zinc structure, 3D printing the copper ink into a porous copper lattice structure using the 3D model, heat treatment of the porous copper lattice structure producing a heat treated porous copper lattice structure, surface modification of the heat treated porous copper lattice structure by nanowires growth on the heat treated porous copper lattice structure producing a heat treated porous copper lattice structure with nanowires, and electrodeposition of zinc onto the heat treated porous copper lattice structure with nanowires to produce the porous copper-zinc structure. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/457834 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/18 (20210101) Original (OR) Class B22F 10/64 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/52 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173582 | Conner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Brett Page Conner (Lee's Summit, Missouri); Benjamin Ross Brown (Lee's Summit, Missouri) |
| ABSTRACT | A system and method of testing a part manufactured using an additive manufacturing process. The part may be excited via an input mechanism that imparts an excitation force on the part to induce a dynamic response in the part. An output mechanism may be used to sense the dynamic response in the part. A processing element may be used to compare the dynamic response with a reference to identify an indication of excess powder in the part. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/540926 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/68 (20210101) Original (OR) Class B22F 12/90 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174736 | Huber et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George W. Huber (Middleton, Wisconsin); Kevin L. Sánchez-Rivera (Madison, Wisconsin); Reid C Van Lehn (Madison, Wisconsin); Ted Walker (Madison, Wisconsin); Panzheng Zhou (Madison, Wisconsin) |
| ABSTRACT | Disclosed herein is a method to recover constituent polymers in multilayer plastic films or mixed plastic wastes. The method comprises selectively dissolving a polymer in a solvent at a temperature, wherein the polymer is soluble, but other polymers in the multilayer plastic film or mixed plastic waste are not. The solubilized polymer is then separated from the multilayer plastic film or mixed plastic waste by mechanical filtration and precipitated by changing the temperature and/or adding a cosolvent. The process is repeated for each of the polymer component, resulting in a number of segregated streams that can then be recycled. Computational tools can be used to select solvent systems and temperatures that selectively dissolve different polymers from among all of the components. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 17/989960 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/08 (20130101) Original (OR) Class C08J 2323/06 (20130101) C08J 2323/08 (20130101) C08J 2323/12 (20130101) C08J 2327/06 (20130101) C08J 2329/04 (20130101) C08J 2367/02 (20130101) C08J 2377/02 (20130101) C08J 2377/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174796 | Kung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); Argonne National Laboratory (Lemont, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harold H. Kung (Evanston, Illinois); Kyoo-Chul Kenneth Park (Evanston, Illinois); Jian Cao (Evanston, Illinois); Neelesh A. Patankar (Evanston, Illinois); Kornel F. Ehmann (Evanston, Illinois); Suman Bhandari (Evanston, Illinois); Christian John Machado (Evanston, Illinois); Zilin Jiang (Evanston, Illinois); Tom Yu Zhao (Evanston, Illinois); Meltem Urgun-Demirtas (Lemont, Illinois) |
| ABSTRACT | A method of forming a metasurface includes forming a plurality of channels on a surface of a formed from a first material, like a metal, ceramic, or polymer. The method also includes filling the plurality of channels in the surface of the base substrate with a second material that is different from the first material to form a metasurface on the base substrate. The method further includes placing the metasurface into a heat exchange system such that the metasurface is proximate to a liquid used in the heat exchange system. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061048 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 5/1618 (20130101) Original (OR) Class C09D 5/1681 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174922 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taek Soon LEE (Berkeley, California); Jinho KIM (Emeryville, California) |
| ABSTRACT | The present invention provides for a genetically modified yeast host cell capable of producing elevated levels of 3-methyl-3-butene-1-ol or isoprenol. |
| FILED | Wednesday, July 07, 2021 |
| APPL NO | 18/014004 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/18 (20130101) Original (OR) Class C12N 15/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175021 | JIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Yong-Su JIN (Urbana, Illinois); Nurzhan KUANYSHEV (Urbana, Illinois); Jing-Jing LIU (Moraga, California); Anshu DEEWAN (Urbana, Illinois); Christopher V. RAO (Urbana, Illinois); Balaji PANNEERSELVAM (Urbana, Illinois); Diwakar SHUKLA (Urbana, Illinois); Sujit JAGTAP (Urbana, Illinois) |
| ABSTRACT | The present disclosure provides genetically engineered microorganisms for the simultaneous fermentation of pentose and hexose sugars, for example, glucose and xylose. The microorganisms can be modified to express AtSWEET polypeptides, LST1 polypeptides, mutants thereof, homologs thereof or combinations thereof. Also provided are methods of co-fermenting hexose and pentose sugars, methods of increasing the conversion of lignocellulosic biomass via microbial fermentation, and methods of generating biofuel. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/918040 |
| CURRENT CPC | Peptides C07K 14/39 (20130101) C07K 14/43 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175139 | Fouliard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Quentin Fouliard (Winter Park, Florida); Ranajay Ghosh (Oviedo, Florida); Seetha Raghavan (Oviedo, Florida) |
| ABSTRACT | A phosphor thermometry device includes a laser that generates a laser pulse onto a thermal barrier coating (TBC) applied onto a substrate. A metallic bond coat layer is on the substrate. A ceramic top coat layer is on the bond coat layer and includes an undoped layer and a doped sensing layer having co-doped first and second rare-earth luminescent dopants that emit respective first and second different emission wavelengths upon excitation by the laser pulse. A detector receives reflected, convoluted luminescence signals from the TBC. First and second photomultiplier devices detect respective first and second different emission wavelengths of the convoluted luminescence signals. A controller receives and processes signals generated from respective first and second photomultiplier devices and determines luminescence lifetime decay and intensity variations for each of the respective first and second rare-earth luminescent dopants for temperature monitoring of the TBC. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/034098 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/48 (20130101) C04B 2235/3224 (20130101) C04B 2235/3246 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/02 (20130101) C09K 11/7787 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175146 | Kashi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Twelve Benefit Corporation (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ajay R. Kashi (Berkeley, California); Aya K. Buckley (Berkeley, California); Sichao Ma (Dublin, California); Kendra P. Kuhl (Oakland, California); Sara Hunegnaw (Oakland, California); Etosha R. Cave (Berkeley, California); Luka Stevic (Novi Sad, Serbia) |
| ABSTRACT | Systems and methods for increasing the concentration of a desired COx reduction reaction product are described. In some embodiments, the systems and methods include ethylene purification. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063508 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 1/12 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/26 (20210101) Original (OR) Class C25B 9/19 (20210101) C25B 11/075 (20210101) C25B 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175228 | Zeng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiangwu Zeng (Solon, Ohio); Xuefei Wang (Cleveland Heights, Ohio); Xu Yang (Tianjin, China PRC); Xinyao Li (Cleveland, Ohio) |
| ABSTRACT | A hybrid offshore wind turbine includes a monopile, friction wheel, and suction bucket. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/943975 |
| CURRENT CPC | Foundations; Excavations; Embankments; Underground or Underwater Structures E02D 27/425 (20130101) Original (OR) Class E02D 27/525 (20130101) Wind Motors F03D 13/22 (20160501) F03D 13/25 (20160501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175630 | HU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); Diakont Advanced Technologies, Inc. (Carlsbad, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liangbing HU (Rockville, Maryland); Paul ALBERTUS (Takoma Park, Maryland); Qi DONG (Newton, Massachusetts); Chengwei WANG (College Park, Maryland); Edward PETIT de MANGE (Carlsbad, California) |
| ABSTRACT | A system for in situ repair of a metal pipe has a pipe repair head, an actuation assembly, an electrical power supply, and a controller. The pipe repair head can have an arm extending along a radiation direction of the pipe and a Joule heating element coupled to a distal end portion of the arm. The actuation assembly can move the pipe repair head along the axial and/or circumferential directions of the metal pipe. The controller controls the actuation assembly to position the pipe repair head with respect to a surface portion of the inner circumferential wall. The controller can then control the electrical power supply to apply a current pulse to the Joule heating element so as to generate a temperature of at least 1000° C. proximal to the surface portion, thereby sintering a metal powder in a slurry on the surface portion to form a metal repair layer. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991323 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 55/18 (20130101) F16L 55/1645 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175745 | Bahar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FFI IONIX IP, INC. (Wilmington, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bamdad Bahar (Georgetown, Delaware); Peter Mark Golben (Florida, New York); William Parmelee (Dover, Delaware) |
| ABSTRACT | A heat exchanger incorporates a metal hydride heat exchanger and mitigates the fluid mixing process, and thus greatly improves the heat transfer efficiency and heat recovery processes. The metal hydride heat exchanger has a container for the metal hydride that has a large aspect ratio. A plurality of high aspect container for the metal hydride may be coupled with a manifold. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103317 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 17/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175888 | Nguyen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hoang T. Nguyen (Livermore, California); Michael C. Rushford (Livermore, California) |
| ABSTRACT | A spectral beam combining system includes a spectral channel splicer comprising a plurality of reflectors and a spectral beam combiner comprising a diffraction optical element such as a diffraction grating. This spectral beam combining system may facilitate combining an increased number of spectral channels thereby producing higher optical power of the combining beam system. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/457417 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) G01J 3/18 (20130101) G01J 3/021 (20130101) G01J 3/0208 (20130101) Original (OR) Class G01J 2003/102 (20130101) G01J 2003/1861 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175891 | FESSLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KIMBERLY ALICIA STRANGE FESSLER (AIKEN, South Carolina); STEVEN MICHAEL SERKIZ (AIKEN, South Carolina) |
| ABSTRACT | Methods and systems are described for use in determination of the presence, type (static or AC), direction, and/or strength of an electric field. Methods include examination of a gaseous sample to determine the presence of perturbation effects brought about by dielectrophoretic forces acting on components of the gaseous sample, and thereby, to identify the presence of an electric field. Examination of a gaseous sample can include Raman spectroscopy. A gaseous sample can be analyzed to determine the presence of molecular polarization due to an induced dipole on a polarizable molecule. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545106 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) G01J 3/44 (20130101) Original (OR) Class G01J 3/0218 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176006 | Gartia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Manas Ranjan Gartia (Baton Rouge, Louisiana); Sushant P. Sahu (Baton Rouge, Louisiana); Christopher G. Arges (Baton Rouge, Louisiana); Deepra Bhattacharya (Baton Rouge, Louisiana); Gokul Venugopalan (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Manas Ranjan Gartia (Baton Rouge, Louisiana); Sushant P. Sahu (Baton Rouge, Louisiana); Christopher G. Arges (Baton Rouge, Louisiana); Deepra Bhattacharya (Baton Rouge, Louisiana); Gokul Venugopalan (Baton Rouge, Louisiana) |
| ABSTRACT | Disclosed herein is a sensor for measuring perfluoroalkyl acids and/or polyfluoroalkyl acids. The sensor includes a working electrode, a counter electrode and optionally a reference electrode. The working electrode includes a film disposed on the surface of the working electrode and the film includes a perfluorinated anion exchange ionomer. A method of using the sensor to detect perfluoroalkyl acids and/or polyfluoroalkyl acids is also described. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/060201 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/301 (20130101) G01N 27/4045 (20130101) G01N 27/4074 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176030 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Timothy C. Johnson (Richland, Washington); Christopher E. Strickland (Ellensburg, Washington); Yue Zhu (Richland, Washington); Jonathan N. Thomle (West Richland, Washington); James C. Stegen (Richland, Washington) |
| ABSTRACT | Systems for determining GW/SW interaction are provided. The systems can include: a sensing assembly comprising sensors for pressure, fluid conductivity, temperature, and transfer resistance; processing circuitry operatively coupled to the sensing assembly and configured to receive data from the sensing assembly and process the data to provide a GW/SW interaction, wherein the data includes pressure, fluid conductivity, temperature, transfer resistance data. Methods for determining GW/SW interaction are provided. The methods can include: receiving real time data including pressure, fluid conductivity, temperature, and transfer resistance; from at least some of the data received simulating the SW/GW interaction; and fitting the real time data with the simulated data to provide actual SW/GW interaction. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 17/988704 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 13/02 (20130101) G01K 13/12 (20130101) G01K 13/026 (20210101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 19/083 (20130101) G01L 19/0092 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/088 (20130101) G01N 33/246 (20130101) Original (OR) Class G01N 2030/0095 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 27/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230177642 | Kudyshev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Zhaxylyk A. Kudyshev (West Lafayette, Indiana); Demid Sychev (West Lafayette, Indiana); Zachariah Olson Martin (West Lafayette, Indiana); Simeon I. Bogdanov (West Lafayette, Indiana); Xiaohui Xu (West Lafayette, Indiana); Alexander Kildishev (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana); Vladimir Shalaev (West Lafayette, Indiana) |
| ABSTRACT | A method of providing super-resolved images of a photon emitting particle is disclosed, which includes providing a machine-learning (ML) platform, wherein the ML platform is configured to receive pixel-based sparse autocorrelation data and generate a predicted super-resolved image of a photon emitting particle, receiving photons from the photon emitting particle by two or more photon detectors, each generating an electrical pulse associated with receiving an incident photon thereon, generating sparse autocorrelation data from the two or more photon detectors for each pixel within an image area, and inputting the pixel-based sparse autocorrelation data to the ML platform, thereby generating a predicted super-resolved image of the imaging area, wherein the resolution of the super-resolved image is improved by √n as compared to a classical optical microscope limited by Abbe diffraction limit. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858722 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/0072 (20130101) Image Data Processing or Generation, in General G06T 3/4046 (20130101) G06T 3/4053 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178710 | Viswanathan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venkatasubramanian Viswanathan (Pittsburgh, Pennsylvania); Zeeshan Ahmad (Pittsburgh, Pennsylvania); Shang Zhu (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure is directed to a battery that comprise at least one electrochemical cell that comprises a cathode, an anode or an anode current collector and an electrolyte disposed between the cathode and the anode or the current collector, wherein (a) the anode comprises an isotopically enriched metal; (b) the cathode comprises isotopically enriched metal ions; (c) the electrolyte comprises an isotopically enriched metal salt; (d) a combination of (a) and (b); (e) a combination of (a) and (c); (f) a combination of (b) and (c); or (g) a combination of (a), (b) and (c). |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/927455 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) Original (OR) Class H01M 4/0447 (20130101) H01M 4/661 (20130101) H01M 50/497 (20210101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178797 | ROUDEBUSH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies, Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John ROUDEBUSH (San Francisco, California); Naoki NITTA (Alameda, California); Yulia TRENIKHINA (Alameda, California); Gleb YUSHIN (Atlanta, Georgia) |
| ABSTRACT | A solid-state Li-ion battery cell includes an anode, a cathode, and a solid electrolyte interposed between the anode and the cathode. The anode includes anode active material and the cathode includes cathode active material. The solid electrolyte includes a melt-infiltration solid electrolyte composition infiltrated in at least a portion of the anode and at least a portion of the cathode. The melt-infiltration solid electrolyte composition includes a lithium halide compound selected from: Li1+xMgxAl1-xCl4, Li2MgCl4, LiCI, and LiAICl4. The solid electrolyte is characterized by a melting temperature of approximately 200° C. or less (e.g., in some designs, approximately 150° C. to approximately 156° C.). |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/062373 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 50/434 (20210101) H01M 2300/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178950 | Eichorst et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Dennis J. Eichorst (Lenexa, Kansas); Tieshu Huang (Kansas City, Missouri); Kaley M. McLain (Kansas City, Missouri); Richard K. Brow (Rolla, Missouri) |
| ABSTRACT | An electrical connector comprises an outer shell, at least one pin, and an insulating seal. The outer shell includes at least one side wall defining a cavity and having an inner surface. The outer shell is formed from electrically conductive material. The pin is positioned within the cavity and is also formed from electrically conductive material. The insulating seal is configured to provide electrical isolation of the pin and fills the cavity between the inner surface of the side wall and the pin. The insulating seal is formed from glass doped with a transition metal oxide. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544558 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/521 (20130101) H01R 43/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178960 | Leisher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| INVENTOR(S) | Paul O. Leisher (Dublin, California); Robert J. Deri (Pleasanton, California); Susant K. Patra (Brntwood, California) |
| ABSTRACT | The present technology can be used to control the current injection profile in the longitudinal direction of a high-power diode laser in order to optimize current densities as a function of position in the cavity to promote higher reliable output power and increase the electrical to optical conversion efficiency of the device beyond the level which can be achieved without application of this technique. This approach can be utilized, e.g., in the fabrication of semiconductor laser chips to improve the output power and wall plug efficiency for applications requiring improved performance operation. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/104064 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/343 (20130101) H01S 5/0421 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230179182 | Zan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xin Zan (Ann Arbor, Michigan); Al-Thaddeus Avestruz (Ann Arbor, Michigan) |
| ABSTRACT | A pulse shaping device includes an inductor that is selectively output-coupled to a first port of a capacitor. The inductor is charged to a selected current throughput and then coupled to the first port to generate a first characteristic within the current flowing at a second port of the capacitor. The capacitor is charged until reaching a clamping voltage at the first port. A voltage clamp of the shaping device clamps the first port of the capacitor at the clamping voltage to generate a second characteristic within the current flowing at a second port of the capacitor. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/077759 |
| CURRENT CPC | Pulse Technique H03K 3/01 (20130101) Original (OR) Class H03K 5/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230172522 | Simeral et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Simeral (Greenwich, Rhode Island); Thomas Hosman (Providence, Rhode Island); Carlos Vargas-Irwin (Providence, Rhode Island); Daniel Thengone (Providence, Rhode Island); Leigh Hochberg (Providence, Rhode Island); Tyler Singer-Clark (Falmouth, Massachusetts) |
| ABSTRACT | Neural signals of a subject intending certain postures can be decoded and a controllable device can be commanded to perform certain actions based on the decoded intended postures with a system, and method of use thereof, including a brain machine interface (BMI) device. The system also includes electrodes in communication with the subject's nervous system to record the neural signals and the controllable device, both in communication with the BMI device. The BMI device can store instructions and previously calibrated neural activity patterns for the certain postures and a processor for receiving the neural signals, pre-processing the neural signals, decoding the neural signals into neural activity patterns, and matching the neural activity patterns to the previously calibrated neural activity patterns. If a match is determined, then the BMI device can send a command, previously linked to the intended posture, to the controllable device to perform the action. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075811 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/375 (20210101) Original (OR) Class A61B 5/384 (20210101) A61B 5/1116 (20130101) A61B 5/7267 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172664 | Samadani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Abdullah ZAHID (Minneapolis, Minnesota); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); Hennepin Healthcare Systems, Inc. (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uzma Samadani (Wayzata, Minnesota); Abdullah Bin Zahid (Norman, Oklahoma) |
| ABSTRACT | Methods and systems for aiding in placement of surgical intervention sites for treating lesions for optimization of surgical outcomes are provided. Also disclosed are computer-aided software packages for identifying the optimal placement of a surgical intervention on a patient in need thereof. The packages, systems, and methods for optimizing placement provided herein help to achieve superior results (e.g. increased drainage), decrease hospitalization time, reduce recurrence of lesions and need for drainage, and improve cognitive outcomes for patients. |
| FILED | Friday, April 19, 2019 |
| APPL NO | 17/048938 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) Original (OR) Class A61B 2034/105 (20160201) A61B 2034/107 (20160201) A61B 2090/367 (20160201) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0016 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230172849 | Zeki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Veterans Affairs Medical Center (Mather, California); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); InVixa, Inc. (Rancho Cordova, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amir A. Zeki (Davis, California); Ramaswamy Krishnan (Boston, Massachusetts); Chandra C. Ghosh (Rancho Cordova, California) |
| ABSTRACT | The present disclosure relates to methods and formulations for treating respiratory viral infections by administering a statin by inhalation. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/997981 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0073 (20130101) Original (OR) Class A61K 31/366 (20130101) A61K 31/573 (20130101) A61K 31/706 (20130101) A61K 31/4709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230173071 | JARMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California); The Regents Of the University of California (Oakland, California); U.S. Government represented by the Development of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John B. JARMAN (Pasadena, California); Dennis A. DOUGHERTY (Pasadena, California); Robert H. GRUBBS (South Pasadena, California); Christopher B. MAROTTA (Valley Village, California); Daniel M. SCHWARTZ (San Francisco, California) |
| ABSTRACT | This current disclosure is directed to compositions based on certain heptamethine dyes useful for generating singlet oxygen using NIR radiation, optionally comprising additives and solvents that enhance the performance of these dyes, and procedures using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near-infrared irradiation to improve the mechanical strength of the sclera. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/082812 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0057 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174601 | Pincus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation For The State University Of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew R. Pincus (Brooklyn, New York); Josef Michl (Little Neck, New York); Ehsan Sarafraz-Yazdi (New York, New York) |
| ABSTRACT | An aspect of the invention provides a method of selectively necrosing cells, comprising: providing a plurality cells, including at least one cancer cell and at least one non-cancerous cell; and administering to the cells a compound, including an HDM-2 targeting component and a cytotoxic component attached to the HDM-2 targeting component, wherein said compound comprises a membrane-active form. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992479 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/02 (20130101) A61K 45/06 (20130101) Peptides C07K 14/4746 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/57407 (20130101) G01N 33/57484 (20130101) G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174668 | PLUVINAGE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Vincent PLUVINAGE (Atherton, California); Anton WYSS-CORAY (Palo Alto, California) |
| ABSTRACT | Provided herein are compositions and methods to treat lysosomal storage disorders. In particular, provided herein are compositions, methods, kits and uses for inhibition or modification of soluble CD22 (sCD22) and its ligand interactions as therapeutic targets in lysosomal storage disorders including Niemann-Pick Disease Type C. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/924612 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Peptides C07K 16/2863 (20130101) C07K 16/2896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175955 | Greco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank A. Greco (Washington, District of Columbia); Eugene B. Hanlon (Washington, District of Columbia) |
| ABSTRACT | The methods, apparatuses, computer-readable media, and systems described enable regions of electromagnetic spectra that may distinguish different biological specimens to be determined. Regions of electromagnetic spectra that distinguish known biological specimens then become candidates for methods to classify unknown specimens and/or make a medical diagnosis. A fraction-product, determined from two arrays associated with two groups, may be used to determine optimal discriminants for the two groups given numerical measurements of particular properties of the members of both groups. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/074364 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4088 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230178177 | Meeks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); Dxige Research, Inc. (Courtenay, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua J. Meeks (Western Springs, Illinois); Andrew Gordon Robertson (Courtenay, Canada); Aurélien de Reyniès (Paris, France); Clarice S. Groeneveld (Paris, France) |
| ABSTRACT | Disclosed are methods and systems for diagnosing, staging, stratifying, prognosing, and/or treating bladder cancer. In particular, the invention relates to methods and systems for classifying Stage T1 bladder cancer. The disclosed methods may include generating an mRNA expression profile for a sample of Stage T1 bladder cancer and classifying the sample based on the expression profile. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 18/003911 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230172212 | Shapiro Ilan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by The Secretary of Agriculture (Washington, District of Columbia); Pheronym, Inc. (Woodland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David I. Shapiro Ilan (Macon, Georgia); Fatma Kaplan (Davis, California) |
| ABSTRACT | The disclosure relates to pheromone extracts from nematode growth medium, and methods of using such nematode extracts to increase the abundance of fungal and bacterial microbials in the soil to promote plant growth, plant health, and to protect plants from environmental stresses including abiotic and biotics stresses. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/061528 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/12 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230174457 | Coats et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel R. Coats (Ames, Iowa); Edmund J. Norris (Oak Forest, Illinois); James Scott Klimavicz (Ames, Iowa) |
| ABSTRACT | The present invention relates to monoterpenoid and phenylpropanoid containing derivative compounds, methods of making the compounds, compositions comprising the compounds, and methods of repelling pests using the compounds and/or compositions. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940585 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/02 (20130101) A01N 37/06 (20130101) A01N 37/08 (20130101) A01N 37/10 (20130101) A01N 43/08 (20130101) A01N 43/10 (20130101) A01N 43/16 (20130101) A01N 43/30 (20130101) A01N 49/00 (20130101) A01N 53/00 (20130101) Acyclic or Carbocyclic Compounds C07C 67/08 (20130101) C07C 69/04 (20130101) C07C 69/07 (20130101) C07C 69/22 (20130101) C07C 69/24 (20130101) C07C 69/63 (20130101) C07C 69/74 (20130101) C07C 69/75 (20130101) Original (OR) Class C07C 69/76 (20130101) C07C 69/533 (20130101) C07C 69/587 (20130101) C07C 69/612 (20130101) C07C 69/618 (20130101) C07C 69/635 (20130101) C07C 69/757 (20130101) C07C 205/43 (20130101) C07C 255/19 (20130101) C07C 2601/02 (20170501) C07C 2601/04 (20170501) C07C 2601/08 (20170501) C07C 2601/14 (20170501) C07C 2601/16 (20170501) C07C 2602/42 (20170501) Heterocyclic Compounds C07D 305/06 (20130101) C07D 305/08 (20130101) C07D 307/68 (20130101) C07D 311/16 (20130101) C07D 333/24 (20130101) C07D 333/38 (20130101) C07D 333/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175003 | Yadav et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Napigen, Inc. (Wilmington, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Narendra Yadav (Wilmington, Delaware); Hajime Sakai (Newark, Delaware); Dilbag Multani (Urbandale, Iowa); Cheryl Caster (Landenberg, Pennsylvania); Emil Orozco (Cochranville, Pennsylvania); Ganesh Kishore (Creve Coeur, Missouri) |
| ABSTRACT | The present disclosure relates to genetically modified cells containing mitochondria that have been transformed with a polynucleotide encoding a phosphite dehydrogenase enzyme, such that the cells can utilize phosphite as a phosphorus source. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075874 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8213 (20130101) C12N 15/8261 (20130101) Original (OR) Class C12N 15/8289 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230175830 | Clonch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Cameron Clonch (Corvallis, Oregon); Bryson Goto (Corvallis, Oregon); Mark Huynh (Corvallis, Oregon); John Selker (Corvallis, Oregon); Chet Udell (Corvallis, Oregon) |
| ABSTRACT | Described herein is a magnetic dendrometer having a frame, a spring-tension mechanism, and a magnet for moving together with the spring-tension mechanism. A magnetic sensor is attached to the frame. The magnetic sensor senses the linear motion of the magnet. This linear motion translates to trackable fluctuations in magnetic field. The magnetic fluctuations are converted to electrical signals by the magnetic sensor. A spring is attached to a free-floating wishbone-style component. The free-floating wishbone-style component is coupled to a slider which has an adjustable, single-contact point with a target (e.g., a vine, a branch, etc.). The frame is a stationary frame that carries the magnetic sensor. The frame connected via the spring to the wishbone/slider combination cooperates with each other for providing linear motion to extend or contract the spring in length directions. The length variations of the dendrometer spring are converted to linear motion of the magnet and then into electronic signals. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/541151 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 5/025 (20130101) G01B 5/0035 (20130101) G01B 7/12 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230176004 | Dong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ENGENIOUSAG LLC (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liang Dong (Ames, Iowa); Xinran Wang (Ames, Iowa) |
| ABSTRACT | Provided herein is technology relating to electrochemical detection of analytes and particularly, but not exclusively, to a double junction reference electrode, methods of using a double junction reference electrode, handheld or robotically manipulable apparatuses comprising a double junction reference electrode, and systems comprising a double junction reference electrode. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/074762 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/40 (20130101) G01N 27/301 (20130101) G01N 27/401 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230179434 | Ganji et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | Technische Universitaet Berlin (Berlin, Germany) |
| INVENTOR(S) | Fatemeh Ganji (Gainesville, Florida); Shahin Tajik (Gainesville, Florida); Jean-Pierre Seifert (Werder Havel, Germany); Domenic Forte (Gainesville, Florida); Mark M. Tehranipoor (Gainesville, Florida) |
| ABSTRACT | Combined physical unclonable function (PUFs); methods, apparatuses, systems, and computer program products for enrolling combined PUFs; and methods, apparatuses, systems, and computer program products for authenticating a device physically associated with a combined PUF are described. In an example embodiment, a combined PUF includes a plurality of PUFs and one or more logic gates. Each PUF includes a plurality of stages and an arbiter configured to generate a single PUF response based on response portions generated by the plurality of stages. The one or more logic gates are configured to combine the single PUF response for each of the plurality of PUFs in accordance with a combination function to provide a combined response. |
| FILED | Tuesday, April 07, 2020 |
| APPL NO | 16/841873 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230177947 | Fry |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark Fry (Marco Island, Florida) |
| ABSTRACT | A health monitor for monitoring the health a user. The system may comprise an edge computing device, a computer, and a health monitor. The health monitor may comprise a sensor module connected to one or more sensors. The health monitor may comprise a data storage logic configured to store the sensor data. The computer may comprise an emergency dispatch module configured to contact an emergency dispatch system; and a healthcare contact module configured to contact a healthcare provider. The health monitor may comprise a command module configured to receive third party contact information; a biographic intake module configured to receive biographic information about the user; and a third-party contact module configured to send a message to a third party; said message comprising sensor module data and the biographic information of the user. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834437 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/02055 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 25/016 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20230178082 | WEI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Yuan-Jun WEI (Broadlands, Virginia) |
| ABSTRACT | Disclosed herein are systems and methods for processing an audio file to perform audio Segmentation and Speaker Role Identification (SRID) by training low level classifier and high level clustering components to separate and identify audio from different sources in an audio file by unifying audio separation and automatic speech recognition (ASR) techniques in a single system. Segmentation and SRID can include separating audio in an audio file into one or more segments, based on a determination of the identity of the speaker, category of the speaker, or source of audio in the segment. In one or more examples, the disclosed systems and methods use machine learning and artificial intelligence technology to determine the source of segments of audio using a combination of acoustic and language information. In some examples, the acoustic and language information is used to classify audio in each frame and cluster the audio into segments. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545710 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/18 (20130101) G10L 15/063 (20130101) G10L 17/18 (20130101) Original (OR) Class G10L 2015/0631 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20230174391 | YIP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| INVENTOR(S) | Ngai Yin YIP (Summit, New Jersey); Chanhee BOO (Seoul, South Korea); Kinnari SHAH (New York, New York); Ian BILLINGE (New York, New York); Robert WINTON (Seattle, Washington); Eliza DACH (New York, New York) |
| ABSTRACT | Systems and methods of performing temperature swing solvent extraction (TSSE) descaling of produced water and desalination of high-salinity brines, e.g., those having a total dissolved solids (TDS) greater than about 250,000 ppm are capable of producing descaled water products including less than about 5% weight percent TDS. The brine/produced water feedstreams and combined with a solvent having temperature-dependent water solubility at a temperature TL. Water is extracted from the feedstream into the solvent to form a water-in-solvent extract component and a raffinate component, from which a solid phase can be precipitated as more water is portioned in the solvent and basicity increases. Heating of the water-in-solvent extract component reduces the solubility of the water therein, producing a biphasic mixture of dewatered solvent and descaled water that can be separated. Because these systems and methods do not require a phase change of water, these products are achieved with significantly higher energy efficiencies when compared to evaporation-based thermal methods. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348139 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/042 (20130101) C02F 1/66 (20130101) C02F 1/265 (20130101) Original (OR) Class C02F 1/444 (20130101) C02F 2103/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230172466 | Gholami et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Autonomous Healthcare Inc. (Hoboken, New Jersey); Stevens Institute of Technology (Hoboken, New Jersey) |
| ASSIGNEE(S) | Autonomous Healthcare Inc. (Hoboken, New Jersey); Stevens Institute of Technology (Hoboken, New Jersey) |
| INVENTOR(S) | Behnood Gholami (Menlo Park, California); Negar Tavassolian (Menlo Park, California); Arash Shokouhmand (Weehawken, New Jersey) |
| ABSTRACT | The present disclosure describes a technology for contactless cardiopulmonary system monitoring, and more specifically, to the embodiment of exemplary system and method for detecting torso movements and estimating respiratory and heart rates. This invention leverages a depth sensor-equipped camera system to determine the human's anatomical landmarks. The estimated coordinates guide an FMCW radar to enhance the signal quality in the direction of the subject through a beam-steering technique, and extract the movements corresponding to the cardiopulmonary system. The movements are used to estimate respiratory and heart rates in a processing unit. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/075407 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/05 (20130101) A61B 5/113 (20130101) A61B 5/0205 (20130101) A61B 5/1126 (20130101) A61B 5/02427 (20130101) Original (OR) Class A61B 5/7246 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230175003 | Yadav et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Napigen, Inc. (Wilmington, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Narendra Yadav (Wilmington, Delaware); Hajime Sakai (Newark, Delaware); Dilbag Multani (Urbandale, Iowa); Cheryl Caster (Landenberg, Pennsylvania); Emil Orozco (Cochranville, Pennsylvania); Ganesh Kishore (Creve Coeur, Missouri) |
| ABSTRACT | The present disclosure relates to genetically modified cells containing mitochondria that have been transformed with a polynucleotide encoding a phosphite dehydrogenase enzyme, such that the cells can utilize phosphite as a phosphorus source. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075874 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8213 (20130101) C12N 15/8261 (20130101) Original (OR) Class C12N 15/8289 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20230174922 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taek Soon LEE (Berkeley, California); Jinho KIM (Emeryville, California) |
| ABSTRACT | The present invention provides for a genetically modified yeast host cell capable of producing elevated levels of 3-methyl-3-butene-1-ol or isoprenol. |
| FILED | Wednesday, July 07, 2021 |
| APPL NO | 18/014004 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/18 (20130101) Original (OR) Class C12N 15/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230172379 | YESSIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES POSTAL SERVICE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel Michael YESSIN (Arlington, Virginia); William Albert TARTAL (Baltimore, Maryland); Joram SHENHAR (Fairfax, Virginia); Joel DEWNANDAN (Bladensburg, Maryland) |
| ABSTRACT | Systems are disclosed for producing audio that is audible outside a collection box for delivery items, the collection box including a user-operated door. The system can include a trigger device, a sensor, an audio transducer that generates the produced audio from an audio signal, an audio chip and one or more processors. The sensor can detect the trigger device when the trigger device is in close proximity, and the one or more processors can be operably connected to the sensor and to the audio chip, where the one or more processors signal the audio chip to send the audio signal to the audio transducer. The one or more processors can further receive and record a status signal indicating that the door is in an opened state. Systems can further include an environmental sensor that measures environmental information. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/161564 |
| CURRENT CPC | Household or Table Equipment A47G 29/22 (20130101) A47G 29/1207 (20130101) A47G 29/1218 (20130101) A47G 29/1225 (20130101) Original (OR) Class A47G 29/1251 (20170801) A47G 2029/1226 (20130101) A47G 2200/08 (20130101) A47G 2200/066 (20130101) A47G 2200/143 (20130101) A47G 2200/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, June 08, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230608.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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