FedInvent™ Patent Applications
Application Details for Thursday, June 15, 2023
This page was updated on Monday, June 19, 2023 at 11:22 PM GMT
Department of Health and Human Services (HHS)
| US 20230180718 | RINBERG et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dmitry RINBERG (Yonkers, New York); Hirofumi NAKAYAMA (Yokohama, Japan) |
| ABSTRACT | A method of training a rodent to identify pairs of same or different odors, whereby the rodent learns the rule irrespective of the particular odors. Once trained, the rodent can be used to measure perceptual odor similarities between members of pairs of odors, which odors may be unrelated to the odors the rodent was trained on. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/906572 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 15/02 (20130101) Original (OR) Class A01K 2227/105 (20130101) A01K 2267/0356 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181042 | Fan et al. |
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| APPLICANT(S) | Spectral MD, Inc. (Dallas, Texas) |
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| INVENTOR(S) | Wensheng Fan (Plano, Texas); Jeffrey E. Thatcher (Irving, Texas); Peiran Quan (Dallas, Texas); Faliu Yi (Allen, Texas); Kevin Plant (Dallas, Texas); Zhicun Gao (Plano, Texas); Jason Dwight (Dallas, Texas) |
| ABSTRACT | Machine learning systems and methods are disclosed for prediction of wound healing, such as for diabetic foot ulcers or other wounds, and for assessment implementations such as segmentation of images into wound regions and non-wound regions. Systems for assessing or predicting wound healing can include a light detection element configured to collect light of at least a first wavelength reflected from a tissue region including a wound or portion thereof, and one or more processors configured to generate an image based on a signal from the light detection element having pixels depicting the tissue region, automatically segment the pixels into wound pixels and non-wound pixels, determine one or more optically determined tissue features of the wound or portion thereof, and generate a predicted or assessed healing parameter associated with the wound or portion thereof over a predetermined time interval. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/820837 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181072 | Berthier et al. |
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| FUNDED BY |
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| APPLICANT(S) | Tasso, Inc. (Seattle, Washington) |
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| INVENTOR(S) | Erwin Berthier (Seattle, Washington); Ben Casavant (Seattle, Washington); Ben Moga (Soquel, California) |
| ABSTRACT | The disclosed apparatus, systems and methods relate to devices, systems and methods for the collection of bodily fluids involving a single-use actuation and retraction mechanism disposed within a collector. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/167734 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/15113 (20130101) A61B 5/15115 (20130101) Original (OR) Class A61B 5/15117 (20130101) A61B 5/15144 (20130101) A61B 5/150022 (20130101) A61B 5/150099 (20130101) A61B 5/150167 (20130101) A61B 5/150175 (20130101) A61B 5/150221 (20130101) A61B 5/150236 (20130101) A61B 5/150908 (20130101) A61B 5/150916 (20130101) A61B 5/150984 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181149 | Konofagou et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Elisa E. Konofagou (New York, New York); Mark Burgess (Ramsey, New Jersey); Robin Ji (New York, New York) |
| ABSTRACT | The present subject matter relates to techniques for simultaneous blood-brain barrier opening and cavitation imaging. The disclosed system can include a transducer and a processor. The transducer can be configured to generate a plurality of focused transmits and simultaneously obtain a plurality of power cavitation images. The processor can be configured to control a parameter of the focused transmits, acquire the power cavitation images between each focused transmit, and generate a cavitation map based on the power cavitation images. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/166615 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) Original (OR) Class A61B 8/488 (20130101) A61B 8/0808 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2007/0039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181360 | Keller et al. |
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| FUNDED BY |
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| APPLICANT(S) | Centricity Vision, Inc. (Carlsbad, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Guild Keller (El Cerrito, California); Thomas Haynes McGaffigan (Saratoga, California); Kevin L. Waltz (Indianapolis, Indiana); Thomas Milton McNicholas (Laguna Niguel, California) |
| ABSTRACT | Embodiments of the invention provide hydrodissection and/or PCO prevention or reduction in a patient undergoing eye surgery. In one embodiment, the invention is a surgical device for cutting and excising a portion of tissue, for example in performing a lens capsulotomy. A capsulotomy tip is inserted into an eye through an incision in the surface of the eye. The capsulotomy tip includes a suction cup to provide suction to the lens capsule. Then suction is applied via the suction cup to secure the capsulotomy tip to the eye. In some embodiments, after the capsulotomy tip is secured to the lens capsule, a cutting element of the capsulotomy tip is used to cut a tissue of the eye. Fluid is pushed through the capsulotomy tip and the capsulotomy tip is removed from the eye. Moreover, disclosed is an intraocular lens (IOL) to be used in conjunction with the surgical device. |
| FILED | Friday, February 03, 2023 |
| APPL NO | 18/164506 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/08 (20130101) A61B 2018/00601 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/16 (20130101) A61F 9/008 (20130101) A61F 9/00754 (20130101) Original (OR) Class A61F 2009/00889 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181416 | Lue et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Tom Lue (Hillsoborough, California); Guiting Lin (San Francisco, California); Ching-Shwun Lin (San Mateo, California); HongXiu Ning (San Francisco, California) |
| ABSTRACT | The treatment of various sensitive organs with low energy acoustic shockwaves has been proposed. However, the prior art is lacking in guidance as to what constitutes an efficacious minimum dosage or a safe maximum dosage for various target organs and tissues. Through extensive experimentation with cultured cells, live animals, and animal disease models, the inventors of the present disclosure have determined safe and efficacious shockwave energetic dosage ranges for vital and sensitive organs, including the brain, pancreas, kidneys, liver, and spleen, as well as for skin and subcutaneous tissues, peripheral nerves, and skeletal muscles. |
| FILED | Saturday, September 17, 2022 |
| APPL NO | 17/933089 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 23/008 (20130101) Original (OR) Class A61H 2205/02 (20130101) A61H 2205/087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181489 | Zhang et al. |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Gao Zhang (Philadelphia, Pennsylvania); Qin Liu (Narberth, Pennsylvania); Dario Carlo Altieri (Philadelphia, Pennsylvania); Meenhard Herlyn (Wynnewood, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions for the treatment of cancer are provided. In one embodiment the composition comprises Gamitrinib and a MAPK inhibitor selected from the MAPK inhibitor is selected from RAF265, AZD6244, PLX4720, PD0325901, LGX818, MEK162, vemurafenib, trametinib and dabrafenib. Methods of treating cancer are also provided. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834667 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/06 (20130101) Original (OR) Class A61K 31/155 (20130101) A61K 31/245 (20130101) A61K 31/437 (20130101) A61K 31/713 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5743 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181504 | Marini et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
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| INVENTOR(S) | Juan C. Marini (Houston, Texas); Sandesh Chakravarthy Sreenath Nagamani (Bellaire, Texas) |
| ABSTRACT | Embodiments of the disclosure include certain formulations for methods of treating urea cycle disorders. The methods encompass compositions that comprise benzoate and phenylbutyrate that may be at certain doses and have certain ratios of the components. The benzoate and phenylbutyrate may act synergistically in treatment of the urea cycle disorders, in particular embodiments. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 18/056231 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/216 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181515 | VASHIST et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARTI VASHIST (MIAMI, Florida); PREM CHAPAGAIN (MIAMI, Florida); ANDREA RAYMOND (MIRAMAR, Florida); HITENDRA CHAND (DORAL, Florida); MADHAVAN NAIR (CORAL GABLES, Florida) |
| ASSIGNEE(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (MIAMI, Florida) |
| INVENTOR(S) | ARTI VASHIST (MIAMI, Florida); PREM CHAPAGAIN (MIAMI, Florida); ANDREA RAYMOND (MIRAMAR, Florida); HITENDRA CHAND (DORAL, Florida); MADHAVAN NAIR (CORAL GABLES, Florida) |
| ABSTRACT | The present invention is directed to a method of treatment or prevention of viral and/or bacterial infection comprising the administration of a polyol derived from a vegetable oil or its derivative. The vegetable oil is preferably linseed oil. The invention is also directed to a formulation comprising a vegetable oil-derived polyol. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/078414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/231 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181528 | AGUIRRE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew AGUIRRE (Boston, Massachusetts); Brenton PAOLELLA (Cambridge, Massachusetts); Francisca VAZQUEZ (Cambridge, Massachusetts); Jasper Edgar NEGGERS (Boston, Massachusetts) |
| ABSTRACT | The disclosure is directed to compositions and methods that are useful for the treatment of a neoplasia. Specifically, methods for inducing cell death or reducing cell survival of a neoplastic cell (e.g., rhabomyosarcoma) and methods of treating a subject having a neoplasia characterized by a loss of VPS4 expression are disclosed. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061369 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/403 (20130101) Original (OR) Class A61K 31/404 (20130101) A61K 31/7105 (20130101) A61K 38/21 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181543 | ZHANG et al. |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Rugang ZHANG (Philadelphia, Pennsylvania); Joseph ZUNDELL (Philadelphia, Pennsylvania); Jianhuang LIN (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure is directed to the use of IRE-1 and/or XBP-1 inhibitors to treat cancers having mutations in ARID 1 A over overexpressing CARM1. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/905143 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181579 | GUNJAN |
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| APPLICANT(S) | Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
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| INVENTOR(S) | Akash GUNJAN (Tallahassee, Florida) |
| ABSTRACT | The invention concerns compositions and a method for treating or delaying the onset, progression, or relapse of a cancer in a subject, the method comprising administering, optionally with radiation therapy, two or more of: a DNA-dependent protein kinase catalytic subunit (DNA-PKcs) inhibitor, a poly-ADP ribose polymerase (PARP) inhibitor, an isocitrate dehydrogenase (IDH) inhibitor, a histone acetyltransferase (HAT) inhibitor, a histone deacetylase (HDAC), inhibitor, and a DNA polymerase theta (POLO) inhibitor. The inhibitors can be administered to the subject simultaneously, or sequentially in any order or combination. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/065073 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/444 (20130101) A61K 31/502 (20130101) Original (OR) Class A61K 31/5025 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181588 | Bennett et al. |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
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| INVENTOR(S) | Anton Bennett (New Haven, Connecticut); Jonathan Ellman (New Haven, Connecticut); Haya Jamali (New Haven, Connecticut); Karen S. Anderson (New Haven, Connecticut); Elias Lolis (New Haven, Connecticut); Denton Hoyer (New Haven, Connecticut) |
| ABSTRACT | The present invention provides compounds and methods for treating MKP-5 modulated disease. In certain embodiments, the MKP-5 modulated disease is a fibrotic disease. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 18/047456 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 31/519 (20130101) Original (OR) Class Heterocyclic Compounds C07D 239/78 (20130101) C07D 471/04 (20130101) C07D 491/052 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181589 | LU et al. |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
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| INVENTOR(S) | Tao LU (Carmel, Indiana); Timothy William CORSON (Fishers, Indiana); Matthew MARTIN (Indianapolis, Indiana); Anbukkarasi MUNIYANDI (Indianapolis, Indiana); Mengyao SUN (Zionsville, Indiana); Kamakshi SISHTLA (Indianapolis, Indiana); Aishat Abiola MOTOLANI (Bloomington, Indiana) |
| ABSTRACT | Methods and compositions to prevent or reduce the effects of neovascular eye disease in a subject are provided, wherein the subject is administered a pharmaceutical composition comprising an inhibitor of protein arginine methyltransferase 5 (PRMT5). |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061219 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181593 | Hamilton et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Nalo M. Hamilton (Los Angeles, California); Diana C. Marquez-Garban (Culver City, California); Richard J. Pietras (Sherman Oaks, California) |
| ABSTRACT | The present disclosure relates to methods and compositions for the treatment of cancer (e.g., breast cancer). |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/926408 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/4166 (20130101) A61K 39/39558 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181607 | Fahy et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of the Regents of California (Oakland, California); University College Dublin (Dublin, Ireland) |
| ASSIGNEE(S) | The University of the Regents of California (Oakland, California); University College Dublin (Dublin, Ireland) |
| INVENTOR(S) | John Vincent Fahy (San Francisco, California); Irina Gitlin (San Francisco, California); Wilfred Raymond (San Francisco, California); Stefan Oscarson (Dublin, Ireland) |
| ABSTRACT | Disclosed herein, inter alia, are methods of using thiosaccharide compounds for treating coronavirus infection. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/924662 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 31/7016 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 29/00 (20180101) A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181633 | SELVARAJ et al. |
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| APPLICANT(S) | METACLIPSE THERAPEUTICS CORPORATION (Atlanta, Georgia); EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Periasamy SELVARAJ (Lilburn, Georgia); Luis Enrique MUNOZ (Decatur, Georgia); Ramireddy BOMMIREDDY (Duluth, Georgia); Christopher D. PACK (Atlanta, Georgia); Sampath RAMACHANDIRAN (Duluth, Georgia) |
| ABSTRACT | Disclosed herein is a method for treating a subject having, or at risk of having, a cancer, comprising administering to the subject a therapeutically effective amount of a tumor membrane vesicle (TMV) and a metformin. In some embodiments, the TMV comprises a B7-1 and/or IL-12 molecule anchored to a lipid membrane (e.g., by a GPI anchor). In some embodiments, the methods can further comprise administering an immune checkpoint inhibitor. The methods are useful for reducing tumor size and metastasis, and in improving anti-tumor immune responses. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/427380 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 35/13 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/71 (20130101) C07K 16/2818 (20130101) C07K 16/2896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181636 | HARTWEGER et al. |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harald HARTWEGER (New York, New York); Mila JANKOVIC (New York, New York); Michel NUSSENZWEIG (New York, New York) |
| ABSTRACT | This disclosure provides modified B cells which produce heterologous antibodies and co-express cargo proteins. The modified B cells may be stimulated by binding of a cognate antigen to the heterologous antibodies. The B cells may be reduced or eliminated by contacting the heterologous antibody with an anti-idiotypic antibody. Methods of making, and using the modified B cells for prophylaxis and therapy for a variety of conditions are provided. The B cells are modified at an IgH locus, an IgK locus, and combinations thereof. Modified B cells maintain allelic exclusion. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/906469 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/00 (20130101) Peptides C07K 14/70503 (20130101) C07K 16/4208 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181648 | Yoder et al. |
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| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corp (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mervin C. Yoder (Indianapolis, Indiana); David P. Basile (Indianapolis, Indiana) |
| ABSTRACT | The present disclosure provides compositions and methods for the treatment or prophylaxis of a perfusion disorder, such as ischemia and/or reperfusion injury, in a subject's organ, tissue or extremity by preserving or improving endothelial function, reducing vascular injury, and/or promoting vascular repair. The disclosed compositions comprise endothelial colony-forming cells or a serum-free composition comprising chemically defined media conditioned by endothelial colony-forming cells. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902482 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 13/12 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) C12N 2506/02 (20130101) C12N 2506/03 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181659 | Lam et al. |
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| FUNDED BY |
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| APPLICANT(S) | CZ BIOHUB SF, LLC (San Francisco, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathy Lam (Oakland, California); Peter Spanogiannopoulos (Oakland, California); Peter Turnbaugh (Oakland, California) |
| ABSTRACT | The present disclosure provides materials and methods for selectively engineering at least one bacterial strain among a mixed population of bacterial strains in the gut of a subject. In some embodiments, a bacteriophage comprising at least one nucleic acid is administered which selectively infects a bacterial strain under conditions that allow expression of the nucleic acid. The present disclosure thus provides compositions and methods for precisely modifying or reducing a population of bacteria in a mixed population in the gut microbiome. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/923865 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/70 (20130101) C12N 2310/20 (20170501) C12N 2795/14132 (20130101) C12N 2795/14171 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181670 | Zhang |
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| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Huang-Ge Zhang (Louisville, Kentucky) |
| ABSTRACT | Methods for treating alcohol induced liver injury include administering to a subject an effective amount of a ginger-derived nanoparticle. Methods for decreasing nuclear factor erythroid-2 related factor (Nrf2) activation in a hepatocyte are also provided and include contacting the hepatocyte with an effective amount of a ginger-derived nanoparticle. Pharmaceutical preparations including ginger-derived nanoparticles are further provided. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 18/055153 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/0053 (20130101) A61K 9/5123 (20130101) A61K 9/5176 (20130101) A61K 31/12 (20130101) A61K 31/26 (20130101) A61K 36/31 (20130101) A61K 36/9068 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 1/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181672 | Venditti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Charles P. Venditti (Potomac, Maryland); PamelaSara Elbaz Head (Rockville, Maryland) |
| ABSTRACT | This application provides the first observation of methylmalonylation/malonylation in organic acidemias (OAs), such as methylmalonic acidemia (MMA) and propionic acidemia (PA), which results in modification of enzymes in key pathways dysregulated in OAs, including sirtuin 5 (SIRT5). Hyperacylation of SIRT5 prevents it from de-acylating CPS1 (including removing methymalonyllation), which prevents activation of CPS1 and likewise, inhibits a key component of the glycine cleavage system, GCSH. Based on these observations, provided herein is a mutant form of SIRT5 containing four mutated lysines that cannot accept acyl groups, methods of its use for treating OA patients, and kits. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/923394 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Original (OR) Class Peptides C07K 14/765 (20130101) C07K 2319/43 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181682 | STINCHCOMB et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TAKEDA VACCINES, INC. (CAMBRIDGE, Massachusetts); THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY (ATLANTA, Georgia) |
| ASSIGNEE(S) | TAKEDA VACCINES INC. (CAMBRIDGE, Massachusetts); THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY (ATLANTA, Georgia) |
| INVENTOR(S) | Dan T. STINCHCOMB (Enumclaw, Washington); Claire KINNEY (Fort Collins, Colorado); Richard M. KINNEY (Fort Collins, Colorado); Jill A. LIVENGOOD (Fort Collins, Colorado) |
| ABSTRACT | Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) or dengue-4 (DEN-4) virus constructs. In other embodiments, constructs disclosed herein can be combined in a composition to generate a vaccine against more one or more dengue virus constructs that may or may not be subsequently passaged in mammalian cells. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/064775 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/7048 (20130101) A61K 38/162 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) C07K 14/1825 (20130101) C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/09 (20130101) C12N 15/8613 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181685 | MOR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WAYNE STATE UNIVERSITY (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gil MOR (Southfield, Michigan); Jiahui DING (Detroit, Michigan); Qianqian LI (Troy, Michigan); Jianjun WANG (Troy, Michigan) |
| ABSTRACT | Compositions and methods are provided according to aspects of the present disclosure for inhibition of a pathogenic virus. According to particular aspects, compositions and methods of the present disclosure include degradation of pathogenic viral nucleic acids by interferon-stimulated gene 20-kDa protein (ISG20) and/or a variant thereof, administered to a cell and/or subject to inhibit a pathogenic viral infection of the cell and/or a subject. Compositions and methods are provided according to aspects of the present disclosure wherein providing the ISG20 protein, or a variant thereof, comprises administering a therapeutically effective amount of the ISG20 protein and/or variant, to a subject having, or at risk of having, a viral infection. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/923763 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 47/59 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181688 | SUSIN PIRES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ivan SUSIN PIRES (Cambridge, Massachusetts); Andre PALMER (Bexley, Ohio); Pedro J. CABRALES AREVALO (La Mesa, California) |
| ABSTRACT | The present disclosure provides methods of treating plasma protein imbalances or depletion (e.g., plasma protein imbalances or depletion caused by hemorrhagic shock or other clinical conditions), in particular by administering protein compositions derived from plasma or plasma isolates. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/926479 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/40 (20130101) A61K 38/44 (20130101) A61K 38/385 (20130101) A61K 38/1722 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) Enzymes C12Y 116/03001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181691 | Dubal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Dena Dubal (San Francisco, California); Cana Park (Oakland, California); Saul Villeda (San Francisco, California); Adam Schroer (San Francisco, California); Patrick Ventura (San Francisco, California) |
| ABSTRACT | Provided herein are Platelet Activating Factor 4 (PF4) polypeptide and other compositions and methods for improving cognitive function in an individual comprising treatment with PF4 and other polypeptides. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/799444 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/19 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181698 | Khalili et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Temple University-of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kamel Khalili (Bala Cynwyd, Pennsylvania); Wenhui Hu (Cherry Hill, New Jersey) |
| ABSTRACT | A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-I proviral genome, eradicating the HIV-I proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832457 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 35/12 (20130101) A61K 38/465 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2320/30 (20130101) C12N 2740/16063 (20130101) Enzymes C12Y 301/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181714 | CROWE, Jr. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to antibodies binding to and neutralizing Venezuelan Equine Encephalitis Vims (VEEV) and methods for use thereof. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/999366 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Peptides C07K 16/1081 (20130101) C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/52 (20130101) C07K 2317/55 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181715 | Pardi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raffael Nachbagauer (New York, New York); Peter Palese (New York, New York); Florian Krammer (New York, New York); Adolfo Garcia-Sastre (New York, New York); Alec W. Freyn (New York, New York); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Norbert Pardi (Philadelphia, Pennsylvania); Drew Weissman (Wynnewood, Pennsylvania); Raffael Nachbagauer (New York, New York); Scott Hensley (Philadelphia, Pennsylvania); Peter Palese (New York, New York); Florian Krammer (New York, New York); Adolfo Garcia-Sastre (New York, New York); Alec W. Freyn (New York, New York) |
| ABSTRACT | The present invention relates to compositions and methods for inducing an immune response against influenza virus in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding at least one influenza virus antigen, such as a hemagglutinin antigen or a fragment thereof, neuraminidase antigen or a fragment thereof, nucleoprotein antigen or a fragment thereof, matrix protein 1 antigen or a fragment thereof, or matrix-2 ion channel antigen or a fragment thereof. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/995207 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181717 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linling He (San Diego, California); Jiang Zhu (San Diego, California) |
| ABSTRACT | The present invention provides methods for producing HIV-1 nanoparticle vaccines with enhanced immunogenicity. The methods entail (1) enzymatic digestion of glycan chain on the surface of a self-assembling nanoparticle vaccine displaying an HIV-1 Env derived trimer immunogen, or (2) expression of an HIV-1 nanoparticle construct in an expression system lacking normal glycosylation function for human proteins. Also provided in the invention are HIV-1 nanoparticle vaccines produced with the described methods. The invention further provides methods of using the HIV-1 nanoparticle vaccine compositions described herein in various therapeutic applications, e.g., for preventing or treating viral infections. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/550768 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 38/162 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 47/6929 (20170801) A61K 2039/55516 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181718 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linling He (San Diego, California); Jiang Zhu (San Diego, California) |
| ABSTRACT | The present invention provides methods for producing scaffolded (e.g., nanoparticle presented) or non-scaffolded vaccines that are based on viral immunogenic proteins with a glycan shielded (e.g., HIV-1 Env). The vaccines thus generated demonstrate enhanced immunogenicity and responder frequency. The methods entail (1) enzymatic digestion of glycan chain on the surface of a viral trimer protein immunogen or a self-assembling nanoparticle vaccine displaying the viral immunogen (e.g., an HIV-1 UFO trimer), or (2) expression of a construct encoding the vaccine in an expression system lacking normal glycosylation function for human proteins. Also provided in the invention are vaccine compositions produced with the described methods. The invention further provides methods of using the vaccine compositions described herein (e.g., scaffolded or non-scaffolded HIV-1 vaccines) in various therapeutic applications, e.g., for preventing or treating viral infections. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/743762 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 39/29 (20130101) A61K 39/145 (20130101) A61K 39/215 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Enzymes C12Y 302/01096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181720 | Horwitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of th University of California (Oakland, California) |
| INVENTOR(S) | Marcus A. Horwitz (Los Angeles, California); Qingmei Jia (Los Angeles, California) |
| ABSTRACT | Embodiments of the invention include immunogenic compositions that comprise an attenuated recombinant Francisella tularensis subspecies holarctica Live Vaccine Strain (LVS) having a deletion in a polynucleotide encoding CapB (LVS ΔcapB), wherein the LVS ΔcapB expresses one or more antigens present on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Embodiments of the invention also include methods of immunizing a susceptible host against a pathogen comprising administering to the host a vaccine that comprises an attenuated recombinant Live Vaccine Strain lacking a polynucleotide encoding CapB (LVS ΔcapB), wherein the LVS ΔcapB expresses one or more antigens expressed by a severe acute respiratory syndrome coronavirus 2 (SAR8-CoV-2) polypeptide. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/924304 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/523 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/165 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181723 | ZHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoping ZHU (Clarksville, Maryland); Xiaoyang LIU (Adelphi, Maryland) |
| ABSTRACT | The present disclosure is drawn to HCMV US11 based therapeutics that can be used to target and reduce the activity of the FcRn protein. The disclosure provides a method of treating auto-immune mediated and albumin-mediated diseases in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising HCMV US11 (herein after referred to as “US11”) polypeptide, polypeptide fragments, or variants thereof. The disclosure also provides methods for preventing, or treating, infections of HCMV through administration of a US11 inhibitor. US11 containing vaccine compositions are also provided for stimulation of an anti-US11 immune response for protection against HCMV infection. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/897885 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/162 (20130101) A61K 39/245 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/1131 (20130101) C12N 2710/16133 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181728 | Haile et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas); Tulane University (New Orleans, Louisiana) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); Tulane University (New Orleans, Louisiana) |
| INVENTOR(S) | Colin N. Haile (Houston, Texas); Gregory Cuny (Houston, Texas); Elizabeth B. Norton (New Orleans, Louisiana); Therese Kosten (Houston, Texas) |
| ABSTRACT | The adjuvanted conjugate opioid vaccine described herein is a conjugate of a protein carrier and at least one opioid backbone component or hapten conjugated thereto, admixed with at least one adjuvant. Anti-opioid effects are demonstrated after administration of a vaccine made up of the CRM197 protein carrier linked to a FEN backbone, combined with adjuvants such as dmLT or LTA1. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/925082 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0013 (20130101) A61K 39/39 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 47/42 (20130101) A61K 47/646 (20170801) A61K 47/6415 (20170801) A61K 2039/541 (20130101) A61K 2039/543 (20130101) A61K 2039/575 (20130101) A61K 2039/6037 (20130101) A61K 2039/55544 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181743 | DONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yizhou DONG (Dublin, Ohio); Yuebao ZHANG (Columbus, Ohio); Wenqing LI (Columbus, Ohio); Jingyue YAN (Columbus, Ohio) |
| ABSTRACT | The present disclosure relates to compounds, compositions, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a nucleic acid). |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/925470 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/543 (20170801) Original (OR) Class A61K 47/6929 (20170801) A61K 48/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181761 | Stephanopoulos |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nicholas Stephanopoulos (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Stephanopoulos (Scottsdale, Arizona) |
| ABSTRACT | Described herein are DNA nanostructures (DN) functionalized with proteins and methods for cellular uptake. Cellular uptake of such DNs is linearly dependent on the cell size. The protein corona determines the endolysosomal vesicle escape efficiency of DNs coated with an endosome escape peptide. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/063824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/62 (20170801) A61K 47/6929 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181762 | ZHOU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sheng ZHOU (Memphis, Tennessee); Brian SORRENTINO (Memphis, Tennessee); Yong CHENG (Memphis, Tennessee) |
| ABSTRACT | A construct including a genomic insulator element that exhibits strong enhancer blocking activities in T lymphocytes is provided as are host cells, pharmaceutical compositions and methods of using the construct in the treatment of disease, in particular a disease to be treated with a retroviral vector-modified T lymphocyte. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/924469 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15043 (20130101) C12N 2830/40 (20130101) C12N 2830/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181763 | Chiorini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Sevice (Bethesda, Maryland); Consiglio Nazionale Delle Ricerche (Rome, Italy) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland); Consiglio Nazionale Delle Ricerche (Rome, Italy) |
| INVENTOR(S) | John A. Chiorini (Dayton, Maryland); Giovanni Di Pasquale (Kensington, Maryland); Fabio Mammano (Monterotondo, Italy); Veronica Zorzi (Monterotondo, Italy) |
| ABSTRACT | Provided are methods of transducing hair cells of the inner ear in a subject comprising administering to the subject an adeno-associated viral (AAV) vector comprising a nucleic acid sequence encoding a capsid comprising the amino acid sequence of SEQ ID NO: 1, wherein the AAV vector further comprises a heterologous nucleic acid sequence. Additionally, methods of treating, preventing, or inhibiting a cochlear disorder or balance disorder in a subject comprising administering the AAV vector to the subject are provided. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/922300 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 48/0041 (20130101) Original (OR) Class A61K 48/0066 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181772 | WU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Anna M. WU (Duarte, California); Kirstin A. ZETTLITZ (Duarte, California); Robert E. REITER (Los Angeles, California) |
| ABSTRACT | Disclosed are engineered anti-prostate stem cell antigen (PSCA) fusion proteins and uses thereof to detect and treat cancers expressing PSCA. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/999352 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/1072 (20130101) A61K 51/1093 (20130101) Original (OR) Class A61K 2039/505 (20130101) Peptides C07K 16/3069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181793 | Ding et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaochu Ding (Ithaca, New York); Yadong Wang (Ithaca, New York) |
| ABSTRACT | Poly(glycerol sebacate) (PGS) polymers, which may be referred to as a functionalized poly(glycerol sebacate) polymers. The PGS polymers include pendant aliphatic carboxyl ate groups and/or pendant aryl carboxyl ate groups covalently bound to the glycerol group of the glycerol sebacate backbone of the polymer. Polymeric materials including a plurality of glycerol sebacate groups, where at least a portion of the individual glycerol sebacate groups have a pendant aliphatic carboxylate group and/or pendant aryl carboxyl ate group covalently bound to the glycerol group of the glycerol sebacate group. The PGS polymers or polymeric materials may be crosslinked PGS polymers or polymeric materials. The PGS polymers and polymeric materials may be made by post-polymerization functionalization. The PGS polymers and polymeric materials may be in fiber form. A material, which may be a fabric, may include a fiber or plurality of fibers. A material may be used to form a tissue graft. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/923679 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/507 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/16 (20130101) C08G 63/916 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181796 | Freytes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald O. Freytes (Cary, None); Camilo A. Mora-Navarro (Raleigh, None); Andreea Badileanu (Garner, None) |
| ABSTRACT | Provided herein are systems, devices and methods to automate and optimize the decellularization process of representative tissues, such as soft tissues, for extracellular matrix (ECM)-based scaffold and biomaterial production. The automated decellularization processes and devices significantly reduce the exposure time to reagents, minimize lot-to-lot variability, and largely preserve the native composition of the ECM from the decellularized tissue or species. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/925187 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/225 (20130101) A61L 27/227 (20130101) A61L 27/3633 (20130101) A61L 27/3683 (20130101) Original (OR) Class A61L 2400/06 (20130101) A61L 2430/40 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 27/02 (20130101) C12M 29/00 (20130101) C12M 33/14 (20130101) C12M 41/12 (20130101) C12M 41/32 (20130101) C12M 41/44 (20130101) C12M 41/48 (20130101) C12M 43/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181799 | Losert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wolfgang Losert (Bethesda, Maryland); John T. Fourkas (Bethesda, Maryland); Meghan Driscoll (Berwyn Heights, Maryland); Floyd Bates, II (Upper Marlboro, Maryland); Xiaoyu Sun (Laurel, Maryland); Can Guven (Hilsboro, Oregon); Joshua Parker (Washington, District of Columbia) |
| ABSTRACT | The invention provides method of guiding unidirectional movement of a cell comprising exposing the cell to a surface comprising an asymmetric, three-dimensional pattern of one or a plurality of topographical elements for a time period sufficient to bias actin polymerization within the cell. The invention also provides methods of inducing directional movement of a cell, and methods of harnessing an actin wave within a cell. In addition, the invention provides compositions comprising a contact side, wherein at least a portion of the contact side comprises a cell contact portion comprising an asymmetric, three-dimensional pattern of one or a plurality of topographical elements, and methods of inducing healing of a wound of a subject comprising contacting the wound with the composition. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/059288 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/0243 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181907 | Irazoqui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pedro Irazoqui (Lafayette, Indiana); Gabriel Omar Albors (West Lafayette, Indiana); Daniel Pederson (Lafayette, Indiana); Christopher John Quinkert (Dyer West Lafayette, Indiana); Muhammad Abdullah Arafat (West Lafayette, Indiana); Jack Williams (Lafayette, Indiana); Zhi Wang (West Lafayette, Indiana); John G.R. Jefferys (Oxford, United Kingdom); Thelma Anderson Lovick (Birmingham, United Kingdom); Terry L. Powley (West Lafayette, Indiana); Rebecca Anne Bercich (Terre Haute, Indiana); Henry Mei (Vadnais Heights, Minnesota); Jesse Paul Somann (West Lafayette, Indiana); Quan Yuan (West Lafayette, Indiana); Hansraj Singh Bhamra (San Jose, California) |
| ABSTRACT | Systems and techniques for wireless implantable devices, for example implantable biomedical devices employed for biomodulation. Some embodiments include a biomodulation system including a non-implantable assembly including a source for wireless power transfer and a data communications system, an implantable assembly including a power management module configured to continuously generate one or more operating voltage for the implantable assembly using wireless power transfer from the non-implantable assembly, a control module operably connected to at least one communication channel and at least one stimulation output, the control module including a processor unit to process information sensed via the at least one communication channel and, upon determining a condition exists, to generate an output to trigger the generation of a stimulus. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/079716 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/08 (20130101) A61B 5/14539 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101) A61N 1/0534 (20130101) A61N 1/0548 (20130101) A61N 1/0551 (20130101) A61N 1/3605 (20130101) A61N 1/3611 (20130101) A61N 1/3787 (20130101) A61N 1/36007 (20130101) A61N 1/36053 (20130101) A61N 1/36064 (20130101) A61N 1/36135 (20130101) Original (OR) Class A61N 1/37211 (20130101) A61N 1/37223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181930 | Sawant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University Of Maryland, Baltimore (Baltimore, Maryland); Broncus Medical Inc. (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Sawant (Columbia, Maryland); Robert Timmerman (Westlake, Texas); Yulong Yan (Plano, Texas); Henky Wibowo (San Jose, California); Esther Vicente (Baltimore, Maryland); Arezoo Modiri (Rosedale, Maryland) |
| ABSTRACT | A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/165540 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1031 (20130101) Original (OR) Class A61N 5/1039 (20130101) A61N 5/1045 (20130101) A61N 5/1064 (20130101) A61N 5/1077 (20130101) A61N 2005/1055 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/10076 (20130101) G06T 2207/10088 (20130101) G06T 2207/30061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182137 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheng Sun (Evanston, Illinois); Hao Zhang (Evanston, Illinois) |
| ABSTRACT | A system for performing avidity-based screening includes a microfluidic circuit that has an inlet designed to receive target cells and CAR-T cells that bind to the target cells. A light source illuminates a portion of the microfluidic circuit that includes the CAR-T cells such that photoacoustic pressure is applied to the CAR-T cells. An imaging sensor captures images of the CAR-T cells. A processor is configured to analyze the images to determine if a CAR-T cell has detached from a target cell. Responsive to a determination that the CAR-T cell has detached, the processor records an amount of the photoacoustic pressure applied to the CAR-T cell. A desired avidity is determined based on a photoacoustic force spectrum, which is based on a plurality of photoacoustic pressures applied to a plurality of detached CAR-T cells. The processor also extracts one or more CAR-T cells that exhibit the desired avidity. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080067 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502738 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/027 (20130101) B01L 2300/0816 (20130101) B01L 2300/0867 (20130101) B01L 2400/0487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183075 | Tian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bozhi Tian (Chicago, Illinois); Vishnu Nair (Chicago, Illinois); Aleksander Prominski (Chicago, Illinois) |
| ABSTRACT | Compositions and methods directed to the synthesis and use of silicon carbide with, biomedical applications is provided. The method of synthesis includes providing a polydimethysiloxane (PDM'S) substrate, and irradiating at least a portion of the substrate with a laser under conditions sufficient to produce silicon carbide comprising 3C silicon carbide (3C-SiE). The composition can be used to modulate biological activity through electrical, chemical and heat stimuli. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/995903 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/205 (20170801) C01B 32/977 (20170801) Original (OR) Class Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183168 | Anderson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Daniel Griffith Anderson (Framingham, Massachusetts); Luke Hyunsik Rhym (Cambridge, Massachusetts); Allen Jiang (Boston, Massachusetts); Jacob Witten (Cambridge, Massachusetts); Idris Raji (Boston, Massachusetts) |
| ABSTRACT | Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease). |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080299 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 237/16 (20130101) Original (OR) Class Heterocyclic Compounds C07D 207/09 (20130101) C07D 207/12 (20130101) C07D 211/82 (20130101) C07D 211/86 (20130101) C07D 231/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183207 | Ghosh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Hiroaki Mitsuya (Kumamoto, Japan) |
| ABSTRACT | Bis-amide inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome. |
| FILED | Tuesday, February 09, 2021 |
| APPL NO | 17/995914 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/65 (20130101) C07D 401/12 (20130101) Original (OR) Class C07D 413/12 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183240 | Gray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Stanford, California); Tinghu Zhang (Brookline, Massachusetts); Nicholas Paul Kwiatkowski (Brookline, Massachusetts) |
| ABSTRACT | The present invention provides novel compounds of Formula (I), (II), or (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, ovarian cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., CDK7, CDK12, or CDK13), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/715874 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Heterocyclic Compounds C07D 473/16 (20130101) Original (OR) Class C07D 473/34 (20130101) C07D 487/04 (20130101) Peptides C07K 14/4738 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183246 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | David Harley Thompson (West Lafayette, Indiana); Herman O. Sintim (Westfield, Indiana); Qingqing Qi (West Lafayette, Indiana); Shruti Biyani (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to a telescoped continuous flow Sonogashira coupling synthesis for some lead compounds to support in vivo studies and pre-clinical evaluation. The application of high throughput tools combined with the telescoped continuous synthesis method can enable an efficient and safe synthesis of compounds of interest involving hazardous coupling reagents such as HATU, while minimizing by-product formation. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/926379 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2404 (20130101) B01J 2231/32 (20130101) B01J 2531/824 (20130101) Heterocyclic Compounds C07D 401/06 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183252 | HERGENROTHER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Paul J. HERGENROTHER (Champaign, Illinois); Timothy M. FAN (Mahomet, Illinois); Riley L. SVEC (Urbana, Illinois) |
| ABSTRACT | New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067531 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/485 (20130101) A61K 9/2009 (20130101) A61K 9/2013 (20130101) A61K 9/2018 (20130101) A61K 9/2027 (20130101) A61K 9/2054 (20130101) A61K 9/2059 (20130101) A61K 9/4858 (20130101) A61K 9/4866 (20130101) A61K 31/495 (20130101) A61K 47/02 (20130101) A61K 47/24 (20130101) A61K 47/26 (20130101) A61K 47/34 (20130101) A61K 47/36 (20130101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183253 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RHODE ISLAND HOSPITAL (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qian CHEN (Barrington, Rhode Island); Hongchuan YU (Mansfield, Massachusetts); Yupeng CHEN (Mansfield, Massachusetts) |
| ABSTRACT | Compositions or an assembly of a series of biomimetic compounds include chemical structures that mimic or structurally resemble a nucleic acid base pair. Complexes of nanotubes and agents are useful to deliver agents into the cells or bodily tissues of individuals for therapeutic and diagnostic purposes. Exemplary compounds include those of Formula (I), (III), (V) or (VII), or of Formula (II), (IV), (VI) or (VIII). |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/156306 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/30756 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/542 (20170801) A61K 47/545 (20170801) A61K 47/6925 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/50 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/227 (20130101) A61L 2400/12 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) C07D 487/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183307 | Bishai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltmore, Maryland); TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. Bishai (Baltimore, Maryland); John R. Murphy (Tilghman, Maryland); Laurene Cheung (Baltimore, Maryland); Shashank Gupta (Frederick, Maryland); Cynthia K. Bullen (Baltimore, Maryland) |
| ABSTRACT | The present invention is a DNA expression vector comprising: a toxP: a mutant toxO that blocks Fe-mediated regulation of gene expression; and a DNA sequence encoding a protein, wherein the toxP and the mutant toxO regulate expression of the DNA segment encoding the protein. It is preferred that DNA expression vectors of the present invention include DNA sequences encoding a signal peptide so that a protein expressed is attached to the signal peptide prior to processing. Novel proteins are produced off of the DNA expression vector of the present invention. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/549845 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/34 (20130101) C07K 14/55 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/77 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183312 | MAJZNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robbie G. MAJZNER (Palo Alto, California); Crystal L. MACKALL (Stanford, California); Aidan TOUSLEY (Stanford, California); Michelle MONJE-DEISSEROTH (Stanford, California); Louai LABANIEH (Stanford, California); Christopher MOUNT (Stanford, California) |
| ABSTRACT | Disclosed are chimeric antigen receptors comprising a CD2 co-stimulatory domain that retain function against CD58− and CD58low tumor cells, and CD2 co-stimulatory receptors that promote CAR function against CD58− and CD58low tumor cells. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/904219 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/70507 (20130101) Original (OR) Class C07K 16/2896 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183321 | Rose et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Jason J. Rose (Fox Chapel, Pennsylvania); Anthony W. DeMartino (Pittsburgh, Pennsylvania); Jesus Tejero Bravo (Pittsburgh, Pennsylvania); Mark Thomas Gladwin (Baltimore, Maryland); Matthew R. Dent (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods for the rapid elimination of carbon monoxide (CO) from CO-bound hemoglobin, myoglobin and cytochrome c oxidase in subjects with CO poisoning are described. The disclosed therapy involves the use of rationally designed, modified, regulator of CO metabolism (RcoM) proteins and pharmaceutical compositions thereof, which scavenge carbon monoxide from poisoned tissue. The recombinant RcoM compositions are infused into blood, where they rapidly sequester carbon monoxide and limit the toxic effects of carbon monoxide on cellular respiration, oxygen transport and oxygen utilization. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/998420 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/14 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/02 (20180101) Peptides C07K 14/805 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183359 | Garcia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenan Christopher Garcia (Menlo Park, California); Claudia Yvonne Janda (Palo Alto, California) |
| ABSTRACT | Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety and to an R-spondin agonist. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 18/058194 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 14/435 (20130101) C07K 14/4703 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 2317/75 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/30 (20130101) C07K 2319/70 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101) C12N 2501/10 (20130101) C12N 2501/415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183370 | Mitchell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Duane Mitchell (Gainesville, Florida); Catherine Flores (Gainesville, Florida); Connor Francis (Gainesville, Florida) |
| ABSTRACT | The disclosure provides methods of treating coronavirus infections (e.g., COVID-19) by administering hematopoietic stem cells, with or without an immune checkpoint inhibitor (e.g., PD-1 antagonist). The disclosure also provides methods of treating coronavirus infections (e.g., COVID-19) by adoptive cell transfer of polyclonal T cells and coronavirus-specific T cells (e.g., SARS-CoV-2-specific T cells). |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/916502 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183380 | McCully et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. McCully (Marblehead, Massachusetts); Sidney Levitsky (Boston, Massachusetts); Douglas B. Cowan (West Roxbury, Massachusetts); Pedro J. del Nido (Lexington, Massachusetts); Sitaram M. Emani (Boston, Massachusetts) |
| ABSTRACT | The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/960994 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/42 (20130101) A61B 6/503 (20130101) A61B 8/0883 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/12 (20130101) A61K 35/28 (20130101) A61K 35/34 (20130101) A61K 47/6901 (20170801) A61K 49/0002 (20130101) A61K 49/1821 (20130101) A61K 49/1896 (20130101) A61K 51/0421 (20130101) A61K 51/1203 (20130101) A61K 51/1282 (20130101) Peptides C07K 16/468 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183419 | Navarro et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renato S. Navarro (Ann Arbor, Michigan); Peter X. Ma (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are biodegradable copolymers, methods of lactone polymerization, nanofibrous scaffolds, and methods of regenerating tissue. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/919834 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/507 (20130101) A61L 2430/34 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183643 | Azarin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Samira Azarin (Minneapolis, Minnesota); Casim A. Sarkar (Minneapolis, Minnesota); Kristen A. Lemke (Minneapolis, Minnesota) |
| ABSTRACT | Certain embodiments provide a method of producing a population of induced multipotent placental cells, the method comprising culturing a population of pluripotent stem cells in the presence of an induction media comprising a retinoid, and optionally a Wnt signaling agonist. Certain embodiments also provide cells, compositions, kits and methods of use thereof. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/948024 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0605 (20130101) Original (OR) Class C12N 2500/38 (20130101) C12N 2501/415 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183668 | Bailey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EMMUNE, Inc. (Juno Beach, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles C. Bailey (Jupiter, Florida); Michael D. Alpert (Jupiter, Florida) |
| ABSTRACT | The invention relates generally to non-naturally occurring ACE2 proteins and their use in the treatment of coronavirus infection. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/926440 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4174 (20130101) A61K 38/4813 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 2319/02 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) Original (OR) Class Enzymes C12Y 304/17023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183687 | Sontheimer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik Joseph Sontheimer (Auburndale, Massachusetts); Jonathan Kenneth Watts (Worcester, Massachusetts); Anastasia Khvorova (Westborough, Massachusetts); Nathan Bamidele (Shrewsbury, Massachusetts) |
| ABSTRACT | Chemically modified Neisseria meningitidis (Nme) crRNAs, tracrRNAs, and sgRNAs are provided. Methods of using the Nme crRNAs, tracrRNAs, and sgRNAs for genome editing with a Nme CRISPR nuclease and kits for performing the same are also provided. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 17/964611 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2310/314 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183699 | Chilkoti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh Chilkoti (Durham, North Carolina); Stefan Zauscher (Durham, North Carolina); Lei Tang (Durham, North Carolina); Sonal Deshpande (Durham, North Carolina) |
| ABSTRACT | Compositions and methods disclosed herein can help provide improved delivery of non-natural therapeutic nucleotides for the treatment of diseases such as cancer. An example composition includes an assembly of amphiphilic polynucleotides, where each amphiphilic polynucleotide includes an aptamer portion, a first nucleotide portion, and a second nucleotide portion. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051487 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 15/115 (20130101) C12N 2310/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183700 | McNally |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth McNally (Oak Park, Illinois) |
| ABSTRACT | Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or treating dystrophic diseases such as Limb-Girdle Muscular Dystrophy. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061345 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183709 | ROYBAL et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kole T. ROYBAL (San Francisco, California); Raymond LIU (San Francisco, California) |
| ABSTRACT | The present disclosure generally relates to, inter alia, a new class of chimeric Notch receptors containing a fully humanized transcriptional effector, engineered to modulate gene expression and cellular activities in a ligand-dependent manner. The new chimeric Notch receptors surprisingly retain the ability to transduce signals in response to ligand binding despite that the Notch extracellular subunit (NEC), which includes the negative regulatory region (NRR) previously believed to be essential for the functioning of Notch receptors is completely absent. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. Also provided are compositions and methods useful for producing such receptors, nucleic acids encoding same, engineered cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various diseases such as cancers. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/995751 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 14/705 (20130101) C07K 16/2803 (20130101) C07K 16/2878 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/1138 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183712 | Nair et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikhil Unni Nair (Medford, Massachusetts); Zachary Mays (Medford, Massachusetts); Karishma Mohan (Medford, Massachusetts); Todd Chappell (Malden, Massachusetts); Vikas Trivedi (Medford, Massachusetts) |
| ABSTRACT | Disclosed are methods, systems, components, and compositions for engineering enzymes. Particularly disclosed are methods, systems, components, and compositions for engineering phenylalanine ammonia-lyase (PAL) enzymes and isolating variant PAL enzymes with enhanced enzymatic properties. The variant PAL enzymes disclosed herein or obtained by the methods disclosed herein may be utilized for treating diseases or disorders characterized by elevated blood levels of phenylalanine, such as phenylketonuria (PKU). |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/904690 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/51 (20130101) A61K 47/60 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 15/52 (20130101) Original (OR) Class C12N 15/70 (20130101) C12N 2500/32 (20130101) Enzymes C12Y 403/01024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183741 | Heldermon et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Coy D. Heldermon (Gainesville, Florida); Sanford L. Boye (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides AAV8 vectors and variants thereof that express nucleic acids sharing identity to a codon optimized NAGLU (coNAGLU) that improves transduction and distribution in brain cells and will improve disease outcomes in the Mucopolysaccharidoses IIIB (MPS IIIB) mouse model. The present disclosure also provides methods of treatment of a subject, and methods of transducing one or more brain cells, by administering these vectors, as well as uses of these vectors in the manufacture of medicaments for treatment. The present disclosure also provides compositions and host cells comprising rAAV vectors and rAAV particles that express a coNAGLU heterologous nucleic acid and confer enhanced transduction efficiency in human cells, such as brain cells (e.g., neurons). These compositions may be administered to a subject in need thereof. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/924539 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) C12N 2800/22 (20130101) Enzymes C12Y 302/0105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183748 | FENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | St. Jude Children's Research Hospital, Inc. (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yongqiang FENG (Memphis, Tennessee); Xinying ZONG (Memphis, Tennessee) |
| ABSTRACT | Disclosed are methods for modifying regulatory T cell lineage stability or induction by simultaneously modulating the activity of Foxp3 enhancers, CNS0 and CNS2 or CNS0 and CNS3. Methods for treating cancer, an autoimmune disease or condition, or a regulatory T cell-related disease or condition are also provided. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/550051 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183752 | CZECH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. CZECH (Westborough, Massachusetts); Yuefei SHEN (Millbury, Massachusetts) |
| ABSTRACT | Complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide are provided. Compositions and methods for delivery of complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide to mammals for both research and therapeutic use are provided. Methods of treating or reducing one or more symptoms of type 2 diabetes, prediabetes and/or gestational diabetes are provided. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 18/049724 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2207/12 (20130101) A01K 2217/07 (20130101) A01K 2227/105 (20130101) A01K 2267/0362 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 47/64 (20170801) A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/003 (20130101) C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0653 (20130101) C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183754 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy Lu (Cambridge, Massachusetts); Shota Nakade (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure provides systems, methods, and compositions for a target specific nuclease and a blunting enzyme to correct frameshift mutations for genome editing and treatment of diseases. In some embodiments, the target specific nuclease and the blunting enzyme are combined with a guide RNA and/or a microhomology-mediated end joining (MMEJ) inhibitor. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 18/055718 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183757 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Shuai Li (Durham, North Carolina) |
| ABSTRACT | The present disclosure is related to genetically engineered microbial strains and related bioprocesses for the production of xylitol. Specifically, the use of dynamically controlled synthetic metabolic valves to reduce the activity of certain enzymes, leads to increased xylitol production in a two-stage process. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/995360 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/90 (20130101) C12N 15/70 (20130101) C12N 15/113 (20130101) C12N 2500/34 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/18 (20130101) Original (OR) Class Enzymes C12Y 101/01049 (20130101) C12Y 101/01307 (20130101) C12Y 103/0101 (20130101) C12Y 503/01005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183775 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Oregon (Eugene, Oregon) |
| ASSIGNEE(S) | University of Oregon (Eugene, Oregon) |
| INVENTOR(S) | Catherine Robinson (Eugene, Oregon); Emily Sweeney (Eugene, Oregon); Karen Guillemin (Eugene, Oregon) |
| ABSTRACT | Provided are SpdE polypeptides and variants and nucleic acids encoding the SpdE polypeptides and variants. Also provided are vectors including one or more nucleic acids encoding a SpdE polypeptide or variant and cells including a nucleic acid encoding the SpdE polypeptide or variant, as well as cells expressing a SpdE polypeptide or variant and compositions including such cells and a pharmaceutically acceptable carrier. Finally, methods of detecting presence and/or amount of one or more amino acids in a sample are provided. The methods include contacting the sample with a SpdE protein, measuring diguanylate cyclase activity of the SpdE protein; and comparing the diguanylate cyclase activity of the SpdE protein to a control. The methods can utilize isolated SpdE protein or a cell expressing a SpdE protein. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/067977 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Peptides C07K 14/195 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Original (OR) Class Enzymes C12Y 207/07065 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6806 (20130101) G01N 2333/9125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183788 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chao-ting Wu (Brookline, Massachusetts); George M. Church (Brookline, Massachusetts); Benjamin Richard Williams (Seattle, Washington) |
| ABSTRACT | Novel methods for making high resolution oligonucleotide paints are provided. Novel, high resolution oligonucleotide paints are also provided. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/162118 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6841 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183793 | Kohli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Rahul Kohli (Penn Valley, Pennsylvania); Tong Wang (Philadelphia, Pennsylvania); Emily Schutsky (Waltham, Massachusetts) |
| ABSTRACT | Compositions and methods for carboxymethylation of cytosine containing DNA and applications thereof for direct sequencing of 5mC are disclosed. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/999260 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1007 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6858 (20130101) Original (OR) Class Enzymes C12Y 201/01037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183802 | Yoseph et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Rami Yoseph (Gaithersburg, Maryland); Amy R. Copeland (Washington, District of Columbia); Sri Krishna (North Bethesda, Maryland); Frank J. Lowery, III (Clarksburg, Maryland); Steven A. Rosenberg (Potomac, Maryland); Paul F. Robbins (Chevy Chase, Maryland) |
| ABSTRACT | Provided are methods of preparing an enriched population of T cells having antigenic specificity for a target antigen. The method may comprise isolating T cells from a blood sample of a patient; selecting the isolated T cells which have a gene expression profile; and separating the selected T cells from the unselected cells. The separated selected T cells provide an enriched population of T cells having antigenic specificity for the target antigen. Methods of isolating a TCR, preparing a population of cells that express a TCR, isolated TCRs, isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing a condition in a mammal are also provided. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/906524 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6881 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183808 | Croce |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carlo M. Croce (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlo M. Croce (Columbus, Ohio) |
| ABSTRACT | Provided herein are, in various embodiments, methods of predicting a likelihood of a subject developing an acute myeloid leukemia (AML) or blast crisis (BC), methods of detecting a subject having AML or BC cells susceptible to treatment with a B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) inhibitor, a B-cell lymphoma 2 (Bel -2) inhibitor and/or a Receptor Tyrosine Kinase Like Orphan Receptor 1 (RORI) inhibitor, methods of stratifying subjects having Myelodysplastic syndrome (MDS) or chronic phase chronic myeloid leukemia (CML), and methods of preparing a sample that is useful for performing the disclosed methods. The present invention also provides methods of treating a subject having a leukemia (e.g., MDS AML or CML) with a therapy that increases the expression or activity of miR-15a, miR-15b, miR-16-1 and/or miR-16-2 gene product, reduces the expression or activity of a target of said gene product, or a combination thereof. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/919904 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183811 | Arvanitis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Costas Arvanitis (Atlanta, Georgia); Anton Bryksin (Atlanta, Georgia); Victor Menezes (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a method for determining the effectiveness of a pharmaceutical drug in effecting a change in a biological specimen of a patient. The method comprises injecting a fluid into the patient, the fluid comprising a plurality of microbubbles; directing an ultrasound signal to the biological specimen of the patient; and detecting a level of cfDNA molecules in the patient. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/924765 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183816 | Kurtz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Carlos, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172957 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 35/20 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183818 | ISMAGILOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. ISMAGILOV (Pasadena, California); Nathan SCHOEPP (Pasadena, California); Tahmineh KHAZAEI (Pasadena, California); Jacob T. BARLOW (Camperdown, Australia) |
| ABSTRACT | Provided herein are RNA markers and compositions, methods and systems for the related identification and/or uses in methods for detection of antibiotic susceptibility and resistance in a microorganism, and in particular in N. gonorrhoeae. |
| FILED | Thursday, August 01, 2019 |
| APPL NO | 17/264734 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/025 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183820 | Singer et al. |
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| FUNDED BY |
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| APPLICANT(S) | HELIXBIND, INC. (Marlborough, Massachusetts) |
| ASSIGNEE(S) | HELIXBIND, INC. (Marlborough, Massachusetts) |
| INVENTOR(S) | Alon Singer (Waltham, Massachusetts); Ranjit Prakash (Northborough, Massachusetts); Srinivas Rapireddy (Westborough, Massachusetts); Jork Nolling (Hopedale, Massachusetts) |
| ABSTRACT | Methods and devices for isolating microbial cells from a sample, extracting eukaryotic DNA from a sample, and identifying the microbial species in the sample are disclosed herein. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/870506 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502738 (20130101) B01L 3/502753 (20130101) B01L 2200/16 (20130101) B01L 2200/028 (20130101) B01L 2200/0631 (20130101) B01L 2300/087 (20130101) B01L 2300/0877 (20130101) B01L 2400/0487 (20130101) B01L 2400/0633 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/101 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 2600/16 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183825 | MOORE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Patrick S. MOORE (Pittsburgh, Pennsylvania); Tuna TOPTAN (Pittsburgh, Pennsylvania); Yuan CHANG (Pittsburgh, Pennsylvania) |
| ABSTRACT | In an embodiment, the invention provides a method and reagents for detection of γ-herpesvirus circRNA. In another embodiment, the invention provides a method and reagents for detection of EBV circRNA. In still another embodiment, the invention provides a method and reagents for detection of KSHV circRNA. The method can be expanded to other herpesviruses and even non-herpesviruses that generate circRNA upon cellular infection. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049378 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1133 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/705 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184715 | WEBB |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ian K. WEBB (Whitestown, Indiana) |
| ABSTRACT | A mass spectrometry method comprises generating ions and separating the ions in an ion mobility cell. Some of the generated ions can be contacted with a mobility modifier. The ions can be analyzed with a mass analyzer. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/925471 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/623 (20210101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/4225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184764 | Lipkin et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Walter Ian Lipkin (New York, New York); Nischay MISHRA (New York, New York); Thomas BRIESE (White Plains, New York); Cheng GUO (Fort Lee, New Jersey); Shreyas JOSHI (Fort Lee, New Jersey); Rafal TOKARZ (Queens Village, New York) |
| ABSTRACT | The current disclosure provides compositions, methods, and kits for detecting the exposure to and infection by certain viruses. Specifically, the current disclosure allows for the rapid differential serological detection of exposure to, and infection by viruses. In particular, the current disclosure allows for the rapid differential serological detection of exposure to, and infection by corona virus (SARS-CoV-2). The current disclosure provides for peptides for the differential detection of SARS-CoV-2. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/917184 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) Original (OR) Class G01N 2333/165 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184768 | WOHLSTADTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | MESO SCALE TECHNOLOGIES, LLC. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob N. WOHLSTADTER (Palm Beach Gardens, Florida); George SIGAL (Rockville, Maryland); Anu MATHEW (North Potomac, Maryland); James WILBUR (Germantown, Maryland); Jeffery DEBAD (Ijamsville, Maryland); Christopher CAMPBELL (Columbia, Maryland); Hans BIEBUYCK (Potomac, Maryland); Priscilla KRAI (Germantown, Maryland); Alan KISHBAUGH (Rockville, Maryland); Leonid DZANTIEV (Ellicott City, Maryland); Christopher SHELBURNE (Rockville, Maryland); Pu LIU (Rockville, Maryland); Paul GOODWIN (Frederick, Maryland) |
| ABSTRACT | The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/997267 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2333/11 (20130101) G01N 2333/165 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184769 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunyoung Kim (New Orleans, Louisiana); Zeromeh Gerber (Las Vegas, Nevada); Duna Penn (New Orleans, Louisiana); Carl Sabottke (New Orleans, Louisiana); Rebecca Buckley (Metairie, Louisiana) |
| ABSTRACT | This invention is directed to compositions and methods to detect and treat gastrointestinal diseases. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957853 |
| CURRENT CPC | Fodder A23K 10/00 (20160501) A23K 20/195 (20160501) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/17 (20160801) A23L 33/40 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 29/00 (20180101) Peptides C07K 16/40 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/42 (20130101) C12Q 1/68 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 2333/916 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184770 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zengjie Yang (Philadelphia, Pennsylvania); Yijung Yang (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides methods of diagnosing, preventing, monitoring, and treating brain tumors. In particular, the present disclosure provides methods of using brain tum or biomarkers in exosomes for diagnosing, preventing, monitoring, and treating brain tumors. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/920356 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5076 (20130101) G01N 33/57407 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184776 | Rao et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); Menarini Silicon Biosystems S.p.A. (Bologna, Italy) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Galla Chandra Rao (Princeton Junction, New Jersey); Mark C. Connelly (Doylestown, Pennsylvania); Mariano A. Garcia-Blanco (Hillsborough, North Carolina); Andrew J. Armstrong (Chapel Hill, North Carolina); Rhonda L. Bitting (Hillsborough, North Carolina) |
| ABSTRACT | Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063678 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54326 (20130101) G01N 33/56966 (20130101) G01N 33/57415 (20130101) G01N 33/57434 (20130101) G01N 33/57484 (20130101) Original (OR) Class G01N 33/57492 (20130101) G01N 2333/47 (20130101) G01N 2333/705 (20130101) G01N 2333/4703 (20130101) G01N 2333/4742 (20130101) G01N 2333/70503 (20130101) G01N 2333/70589 (20130101) G01N 2333/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184779 | Henderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey P. Henderson (St. Louis, Missouri); John Isaac Robinson (St. Louis, Missouri); Jan Maureen Crowley (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides methods related to accurate detection and treatment of medical conditions related to Clostridioides difficile infection (CDI). In specific cases, the disclosure concerns accurate assessment of a symptom associated with CDI related to the presence or risk that may or may not be a pathogenic infection. Particular embodiments encompass detection of one or more specific analytes that provide information for accurate diagnosis and treatment of CDI. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/614140 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6812 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184783 | Shlipak et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael George Shlipak (San Francisco, California); Michelle Estrella (San Francisco, California); Joachim H. lx (La Jolla, California); Rebecca Scherzer (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods of determining whether a subject treated for hypertension should continue hypertension treatment. In exemplary embodiments, the method comprises measuring the level of at least two of the following in a urine sample obtained from the subject: (i) Alpha—1 microglobulin (aim); (ii) kidney injury molecule (KIM—1); and (iii) Chitinase-3-like protein (YKL-40); wherein the subject should continue the hypertension treatment, when the levels are decreased or unchanged, relative to a control level, and wherein the subject should discontinue or decrease the hypertension treatment, when the levels are increased, relative to a control level. Related methods, kits, assay systems, systems comprising machine readable instructions, computer-readable storage media, and methods implemented by a processor in a computer are furthermore provided herein. |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/282854 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) Original (OR) Class G01N 2333/54 (20130101) G01N 2333/924 (20130101) G01N 2333/70578 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184786 | Hardt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Forsyth Dental Infirmary for Children, d/b/a The Forsyth Institute (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Markus Hardt (Belmont, Massachusetts); Fabian Schulte (Cambridge, Massachusetts); Wenyuan Shi (Boston, Massachusetts) |
| ABSTRACT | Provided herein are, in various embodiments, methods of detecting an acute inflammatory response associated with a viral infection in a patient, methods of predicting a likelihood of developing an acute inflammatory response (e.g., an acute respiratory distress syndrome) in a patient having a viral infection, such as a SARS-CoV2 infection, and methods of preparing a bodily fluid sample that is useful for performing the disclosed methods. The present invention also provides methods of treating a patient having a viral infection with a therapy that inhibits acute inflammation, such as acute inflammation mediated by the kinin-kallikrein system and/or the renin-angiotensin system (RAS). |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/912677 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2410/02 (20130101) G01N 2410/06 (20130101) G01N 2800/7095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230186055 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Ge Wang (Loudonville, New York); Christopher Wiedeman (Troy, New York) |
| ABSTRACT | In one embodiment, there is provided a dual neck autoencoder module for reducing adversarial attack transferability. The dual neck autoencoder module includes an encoder module configured to receive input data; a decoder module; and a first bottleneck module and a second bottleneck module coupled, in parallel, between the encoder module and the decoder module. The decoder module is configured to generate a first estimate based, at least in part, on a first intermediate data set from the first bottleneck module, and a second estimate based, at least in part, on a second intermediate data set from the second bottleneck module. The first intermediate data set and the second intermediate data set are at least partially decorrelated based, at least in part, on a correlation loss. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/081156 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/094 (20230101) G06N 3/0455 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230186488 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Shaopeng WANG (Chandler, Arizona); Guangzhong MA (Tempe, Arizona) |
| ABSTRACT | Provided herein are methods of tracking molecular dynamics in three dimensions. In some embodiments, the methods include introducing an incident light toward a second surface of a substrate to induce a plasmonic wave at least proximal to a first surface of the substrate. A population of particles is connected to the first surface of the substrate via one or more first biomolecules. In some embodiments, the methods also include detecting a change in position of the particles in the population along at least three dimensions over a duration from a change in intensity of the incident light reflected at an interface of the first surface of the substrate. Related systems and computer readable media are also provided. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/062261 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/246 (20170101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/30024 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230180935 | Fowler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Fowler (Warner Robins, Georgia); Michael Hayes (Warner Robins, Georgia); Kevin Eversley (Macon, Georgia) |
| ABSTRACT | An ergonomic method for working in confined work spaces is disclosed. The method, in some cases, includes the steps of: a) providing a support structure that is generally in the configuration of a rectangular prism having six faces, a length, width, and a height in which the length, width, and height differ from one another so that the structure provides three different height positions when the support structure is placed on the floor of the workspace; b) placing the support structure with one of its faces in contact with a contoured floor surface in a confined work space; and c) sitting or standing on the support structure. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/550362 |
| CURRENT CPC | Chairs; Sofas; Beds A47C 3/16 (20130101) A47C 5/125 (20130101) Original (OR) Class A47C 9/00 (20130101) A47C 15/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181042 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Spectral MD, Inc. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wensheng Fan (Plano, Texas); Jeffrey E. Thatcher (Irving, Texas); Peiran Quan (Dallas, Texas); Faliu Yi (Allen, Texas); Kevin Plant (Dallas, Texas); Zhicun Gao (Plano, Texas); Jason Dwight (Dallas, Texas) |
| ABSTRACT | Machine learning systems and methods are disclosed for prediction of wound healing, such as for diabetic foot ulcers or other wounds, and for assessment implementations such as segmentation of images into wound regions and non-wound regions. Systems for assessing or predicting wound healing can include a light detection element configured to collect light of at least a first wavelength reflected from a tissue region including a wound or portion thereof, and one or more processors configured to generate an image based on a signal from the light detection element having pixels depicting the tissue region, automatically segment the pixels into wound pixels and non-wound pixels, determine one or more optically determined tissue features of the wound or portion thereof, and generate a predicted or assessed healing parameter associated with the wound or portion thereof over a predetermined time interval. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/820837 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181416 | Lue et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Tom Lue (Hillsoborough, California); Guiting Lin (San Francisco, California); Ching-Shwun Lin (San Mateo, California); HongXiu Ning (San Francisco, California) |
| ABSTRACT | The treatment of various sensitive organs with low energy acoustic shockwaves has been proposed. However, the prior art is lacking in guidance as to what constitutes an efficacious minimum dosage or a safe maximum dosage for various target organs and tissues. Through extensive experimentation with cultured cells, live animals, and animal disease models, the inventors of the present disclosure have determined safe and efficacious shockwave energetic dosage ranges for vital and sensitive organs, including the brain, pancreas, kidneys, liver, and spleen, as well as for skin and subcutaneous tissues, peripheral nerves, and skeletal muscles. |
| FILED | Saturday, September 17, 2022 |
| APPL NO | 17/933089 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 23/008 (20130101) Original (OR) Class A61H 2205/02 (20130101) A61H 2205/087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181728 | Haile et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas); Tulane University (New Orleans, Louisiana) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); Tulane University (New Orleans, Louisiana) |
| INVENTOR(S) | Colin N. Haile (Houston, Texas); Gregory Cuny (Houston, Texas); Elizabeth B. Norton (New Orleans, Louisiana); Therese Kosten (Houston, Texas) |
| ABSTRACT | The adjuvanted conjugate opioid vaccine described herein is a conjugate of a protein carrier and at least one opioid backbone component or hapten conjugated thereto, admixed with at least one adjuvant. Anti-opioid effects are demonstrated after administration of a vaccine made up of the CRM197 protein carrier linked to a FEN backbone, combined with adjuvants such as dmLT or LTA1. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/925082 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0013 (20130101) A61K 39/39 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 47/42 (20130101) A61K 47/646 (20170801) A61K 47/6415 (20170801) A61K 2039/541 (20130101) A61K 2039/543 (20130101) A61K 2039/575 (20130101) A61K 2039/6037 (20130101) A61K 2039/55544 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181907 | Irazoqui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pedro Irazoqui (Lafayette, Indiana); Gabriel Omar Albors (West Lafayette, Indiana); Daniel Pederson (Lafayette, Indiana); Christopher John Quinkert (Dyer West Lafayette, Indiana); Muhammad Abdullah Arafat (West Lafayette, Indiana); Jack Williams (Lafayette, Indiana); Zhi Wang (West Lafayette, Indiana); John G.R. Jefferys (Oxford, United Kingdom); Thelma Anderson Lovick (Birmingham, United Kingdom); Terry L. Powley (West Lafayette, Indiana); Rebecca Anne Bercich (Terre Haute, Indiana); Henry Mei (Vadnais Heights, Minnesota); Jesse Paul Somann (West Lafayette, Indiana); Quan Yuan (West Lafayette, Indiana); Hansraj Singh Bhamra (San Jose, California) |
| ABSTRACT | Systems and techniques for wireless implantable devices, for example implantable biomedical devices employed for biomodulation. Some embodiments include a biomodulation system including a non-implantable assembly including a source for wireless power transfer and a data communications system, an implantable assembly including a power management module configured to continuously generate one or more operating voltage for the implantable assembly using wireless power transfer from the non-implantable assembly, a control module operably connected to at least one communication channel and at least one stimulation output, the control module including a processor unit to process information sensed via the at least one communication channel and, upon determining a condition exists, to generate an output to trigger the generation of a stimulus. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/079716 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/08 (20130101) A61B 5/14539 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101) A61N 1/0534 (20130101) A61N 1/0548 (20130101) A61N 1/0551 (20130101) A61N 1/3605 (20130101) A61N 1/3611 (20130101) A61N 1/3787 (20130101) A61N 1/36007 (20130101) A61N 1/36053 (20130101) A61N 1/36064 (20130101) A61N 1/36135 (20130101) Original (OR) Class A61N 1/37211 (20130101) A61N 1/37223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182224 | Paul et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida International University Board of Trustees (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tanaji Paul (Miami, Florida); Arvind Agarwal (Miami, Florida); Cheng Zhang (Miami, Florida); Sohail Mazher Ali Khan Mohammed (Miami, Florida) |
| ABSTRACT | Methods for fabricating high-strength aluminum-boron nitride nanotube (Al—BNNT) wires or wire feedstock from Al—BNNT composite raw materials by mechanical deformation using wire drawing and extrusion are provided, as well as large-scale, high-strength Al—BNNT composite components (e.g., with a length on the order of meters (m) and/or a mass on the order of hundreds of kilograms (kg)). The large-scale, high-strength Al—BNNT composite components can be made via wire-based additive manufacturing. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/065791 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/14 (20220101) B22F 1/107 (20220101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 9/044 (20130101) Original (OR) Class B23K 37/0229 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182876 | Eldred |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross Anthony Eldred (Salinas, California) |
| ABSTRACT | Disclosed is a method and system to provide aResetting Anchor/Antenna Tether Mechanism (RAATM) to provide, according to an exemplary embodiment, dual anchoring and antenna capabilities to autonomous underwater vehicles (AUVs). The RAATM is resettable; an AUV can anchor at one location for a period of time, retrieve the anchor, move to a new location, and redeploy the anchor. Furthermore, the RAATM tether may also be used as an antenna for radio communications while deployed; this may allow smaller AUVs to accomplish missions that would otherwise require larger AUVs with dedicated antennas. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106875 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/26 (20130101) Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/001 (20130101) Original (OR) Class B63G 8/14 (20130101) B63G 2008/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182890 | Wood et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | William B. Wood (Weatherford, Texas); Lawrence M. Corso (Keller, Texas) |
| ABSTRACT | A removable passive airflow oscillation device can be disposed within a pressurized wing structure utilized as a plenum. The passive airflow oscillation device can be a removable insert disposed into exterior vehicle surfaces with pressurization of a sealed chamber to provide the airflow. The device can include a cavity configured to receive the airflow from an ingress opening, direct the airflow therethrough to generate a predetermined oscillating airflow, and expel the oscillatory airflow from the egress opening. The removable passive airflow oscillation devices can provide quick and simple replacement and maintenance of damaged or clogged devices. The aft chamber of the flap seal can be sealed and pressurized to serve as a plenum providing the airflow to the actuators. The device can receive airflow, such as compressor air, and expel an oscillating airflow. Because each device is self-contained the number of devices and location thereof can vary by application. |
| FILED | Friday, February 03, 2023 |
| APPL NO | 18/164560 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Aeroplanes; Helicopters B64C 21/04 (20130101) Original (OR) Class B64C 2230/18 (20130101) Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/0025 (20130101) F15D 1/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182896 | Gilliland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bell Textron Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Colton Gilliland (Northlake, Texas); Russell Mueller (Dallas, Texas) |
| ABSTRACT | A bearing restraint, for use on a rotorcraft with a rotor mast and bearing assembly. The bearing restraint interfacing with a mast groove along the rotor mast to longitudinally restrain the bearing assembly. The bearing restraint includes a pilot ring, groove collar, and retaining ring. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/547578 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/12 (20130101) B64C 27/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183075 | Tian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bozhi Tian (Chicago, Illinois); Vishnu Nair (Chicago, Illinois); Aleksander Prominski (Chicago, Illinois) |
| ABSTRACT | Compositions and methods directed to the synthesis and use of silicon carbide with, biomedical applications is provided. The method of synthesis includes providing a polydimethysiloxane (PDM'S) substrate, and irradiating at least a portion of the substrate with a laser under conditions sufficient to produce silicon carbide comprising 3C silicon carbide (3C-SiE). The composition can be used to modulate biological activity through electrical, chemical and heat stimuli. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/995903 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/205 (20170801) C01B 32/977 (20170801) Original (OR) Class Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183246 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | David Harley Thompson (West Lafayette, Indiana); Herman O. Sintim (Westfield, Indiana); Qingqing Qi (West Lafayette, Indiana); Shruti Biyani (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to a telescoped continuous flow Sonogashira coupling synthesis for some lead compounds to support in vivo studies and pre-clinical evaluation. The application of high throughput tools combined with the telescoped continuous synthesis method can enable an efficient and safe synthesis of compounds of interest involving hazardous coupling reagents such as HATU, while minimizing by-product formation. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/926379 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2404 (20130101) B01J 2231/32 (20130101) B01J 2531/824 (20130101) Heterocyclic Compounds C07D 401/06 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183677 | Voigt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Christopher A. Voigt (Belmont, Massachusetts); Yonatan Chemla (Cambridge, Massachusetts); Itai Levin (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are biosensors that are hyperspectral reporters. The biosensors are useful for detecting information about the environment and environmental conditions in a number of fields including agriculture. Also provided are methods of making and using the biosensors. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/961925 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1055 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183719 | VENKATESAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Malabi M. VENKATESAN (Bethesda, Maryland); Lakshmi CHANDRASEKARAN (Gaithersburg, Maryland); Akamol E. SUVARNAPUNYA (Rockville, Maryland) |
| ABSTRACT | Recombinant Shigella minimal invasion plasmid constructs pRISM and pRISM-G and a method of inducing an immune response to Shigella in a subject, the method comprising administering the composition to the subject in an amount sufficient to induce an immune response to Shigella in the subject. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/923853 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 15/74 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183757 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Shuai Li (Durham, North Carolina) |
| ABSTRACT | The present disclosure is related to genetically engineered microbial strains and related bioprocesses for the production of xylitol. Specifically, the use of dynamically controlled synthetic metabolic valves to reduce the activity of certain enzymes, leads to increased xylitol production in a two-stage process. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/995360 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/90 (20130101) C12N 15/70 (20130101) C12N 15/113 (20130101) C12N 2500/34 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/18 (20130101) Original (OR) Class Enzymes C12Y 101/01049 (20130101) C12Y 101/01307 (20130101) C12Y 103/0101 (20130101) C12Y 503/01005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183879 | Choi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHOLOGY (Hoboken, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| INVENTOR(S) | Chang-Hwan Choi (Tenafly, New Jersey); JungHoon Lee (Busan, South Korea) |
| ABSTRACT | A method for creating oil-filled porous anodic oxide coatings for stainless steel is disclosed. The coating has anti-corrosion and omniphobic properties to resist both atmospheric conditions, or other conditions with exposure to vapor, and wet conditions, in which the coating is exposed to and/or immersed in liquid. The anodic oxide coating of the present invention can be made by the steps of cleaning and/or electropolishing a steel substrate, applying anodic oxidation to the steel substrate, washing the steel substrate in an organic solvent, and annealing the substrate at high temperature. To fill the porous coating with an oil, a solvent exchange method may be applied. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971328 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/08 (20130101) C09D 127/18 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/36 (20130101) C25D 5/48 (20130101) Original (OR) Class C25D 11/02 (20130101) Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183915 | Limpaecher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Erik Limpaecher (Concord, Massachusetts); Jacob Clayton (, None); Douglas Baker (, None); William Hornsby (Fort Belvoir, Virginia) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); United States Marine Corps (Washington, District of Columbia) |
| INVENTOR(S) | Erik Limpaecher (Concord, Massachusetts); Jacob Clayton (Cambridge, Massachusetts); Douglas Baker (Cambridge, Massachusetts); William Hornsby (Fort Belvoir, Virginia) |
| ABSTRACT | Devices and methods related to drying absorbent articles with water reactive materials are generally described. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/334017 |
| CURRENT CPC | Domestic Washing or Cleaning; Suction Cleaners in General A47L 23/20 (20130101) Laundering, Drying, Ironing, Pressing or Folding Textile Articles D06F 60/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184505 | Curliss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Proof Research, Inc. (Columbia Falls, Montana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Brian Curliss (Beavercreek, Ohio); Vincent Steffan Francischetti (Columbia Falls, Montana); Nicholas Elmo Jack (Kalispell, Montana) |
| ABSTRACT | An improved hybrid composite projectile barrel comprising an inner liner and an outer composite matrix, the inner liner having a breech transition region and a muzzle transition region. The breech transition region and the muzzle transition region each comprises locking features that secure the outer composite matrix to the inner liner at the transition regions. In a first embodiment, the locking features are a series of longitudinally extending ribs with notches. In a second embodiment, the locking features are a plurality of pins disposed around the circumference of the breech and muzzle transition regions. In a third embodiment, the ridges and pins are combined such that a pin extends from the top of each ridge. In each embodiment with pins, the height of the pins is preferably adjusted so that the top ends of the pins form a line that is parallel with the outer diameter of the inner liner. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/941837 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 21/04 (20130101) Original (OR) Class F41A 21/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184623 | Stievater et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd H. Stievater (Arlington, Virginia); Nathan Tyndall (Alexandria, Virginia); Marcel W. Pruessner (Chevy Chase, Maryland) |
| ABSTRACT | A method and system for obtaining photonic parameters. The system includes a computer, an optical source, a first and second optical fiber, a Mach-Zehnder Interferometer (MZI) structure, and a detector. The computer includes a processor and memory. The optical source is constructed to emit light of a first optical mode and a second optical mode in response to an instruction by the computer. The first optical fiber receives the first or second optical mode. The MZI structure includes first and second pluralities MZIs and receives the first or second optical mode from the optical fiber. The second optical fiber receives light from the MZI structure. The detector is configured to receive light that propagated through the second optical fiber, generate image data and provide the image data to the computer. The computer obtains a plurality of photonic parameters based on the image data and initial guesses for the plurality of photonic parameters. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/081424 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/331 (20130101) Original (OR) Class G01M 11/333 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184776 | Rao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); Menarini Silicon Biosystems S.p.A. (Bologna, Italy) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Galla Chandra Rao (Princeton Junction, New Jersey); Mark C. Connelly (Doylestown, Pennsylvania); Mariano A. Garcia-Blanco (Hillsborough, North Carolina); Andrew J. Armstrong (Chapel Hill, North Carolina); Rhonda L. Bitting (Hillsborough, North Carolina) |
| ABSTRACT | Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063678 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54326 (20130101) G01N 33/56966 (20130101) G01N 33/57415 (20130101) G01N 33/57434 (20130101) G01N 33/57484 (20130101) Original (OR) Class G01N 33/57492 (20130101) G01N 2333/47 (20130101) G01N 2333/705 (20130101) G01N 2333/4703 (20130101) G01N 2333/4742 (20130101) G01N 2333/70503 (20130101) G01N 2333/70589 (20130101) G01N 2333/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184957 | Ferguson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Oren Ferguson (San Diego, California); Ceferino Teodoro Fajardo, III (San Diego, California) |
| ABSTRACT | A method and device determines an evolving position of a device using electromagnetic interference, which is jamming electromagnetic navigation signals. An antenna arrangement receives both the electromagnetic navigation signals and the electromagnetic interference. A discerned position is determined for each of one or more jamming antennas emitting the electromagnetic interference. A detection circuit determines each discerned position from the electromagnetic interference received at the device and at least one measurement of the evolving position using the electromagnetic navigation signals. The evolving position of the device is determined while the electromagnetic interference prevents subsequently measuring the evolving position using the electromagnetic navigation signals. An evaluation circuit determines the evolving position from the electromagnetic interference received at the device and from each discerned position of the one or more jamming antennas. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546940 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/21 (20130101) Original (OR) Class G01S 19/48 (20130101) G01S 19/49 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230186072 | Le et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thai F. Le (West Palm Beach, Florida); Supriyo Chakraborty (White Plains, New York); Mudhakar Srivatsa (White Plains, New York) |
| ABSTRACT | Providing an explanation for model outcome can include receiving input data, and passing the input data through an attention-based neural network, where the attention-based neural network learns attention weights associated with contextual embeddings corresponding to tokens of the input data and predicts an outcome corresponding to the input data. Based on an attention weight associated with a contextual embedding corresponding to a token of the input data, a signed relevance score can be determined to associate with the token for quantifying the token's relevance to the outcome. Based on the signed relevance score, an explanation of the token's contribution toward or against the outcome can be provided. The signed relevance score can be computed as a gradient of loss with respect to the attention weight. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/549090 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230186120 | ZHAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intelligent Fusion Technology, Inc. (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingliang ZHAO (Germantown, Maryland); Jiaoyue LIU (Germantown, Maryland); Nichole SULLIVAN (Germantown, Maryland); Kuochu CHANG (Fairfax, Virginia); Erik BLASCH (Arlington, Virginia); Genshe CHEN (Germantown, Maryland) |
| ABSTRACT | A computing system includes: a memory, containing instructions for a method for anomaly and pattern detection of unstructured big data via semantic analysis and dynamic knowledge graph construction; a processor, coupled with the memory and, when the instructions being executed, configured to: receive unstructured big data associated with social network interactions, events, or activities; parse and structure the unstructured big data to generate structured big data; form a dynamic knowledge base based on the structured big data; and perform sematic reasoning on the dynamic knowledge base to discover patterns and anomalies among the social network interactions, events, or activities; and a display, comprising an interactive graphical user interface (GUI), configured to receive the anomalies and patterns to display real-time actionable alerts, provide recommendations, and support decisions. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/534754 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/26 (20190101) G06F 16/258 (20190101) G06F 40/30 (20200101) G06F 40/295 (20200101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Original (OR) Class G06N 5/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230186620 | ZHAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intelligent Fusion Technology, Inc. (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qi ZHAO (Germantown, Maryland); Huong Ngoc DANG (Germantown, Maryland); Yi LI (Germantown, Maryland); Xin TIAN (Germantown, Maryland); Nichole SULLIVAN (Germantown, Maryland); Genshe CHEN (Germantown, Maryland); Khanh PHAM (Kirtland AFB, New Mexico) |
| ABSTRACT | A system includes: a named data networking (NDN) based Spark distributed computing network including a Spark distributed computing network including a master computer node and a plurality of slave computer nodes, and a named data networking (NDN) protocol installed on the Spark distributed computing network, and a coded distributed computing (CDC) target recognition model deployed on the NDN-based Spark distributed computing network. The NDN-based Spark distributed computing network is configured to: receive one or more batches of input images; generate a parity image from each batch of the input images; predict a label for each image of the batch of the input images; process the generated parity image; upon a label prediction of one image of the batch of the input images being unavailable, reconstruct the unavailable label prediction; and classify labels for the input images. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/551436 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/95 (20220101) Original (OR) Class G06V 10/96 (20220101) G06V 10/764 (20220101) G06V 10/7715 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187018 | Cooks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Nicolás M. Morato (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to integrated synthesis and analysis systems and methods of use thereof. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/923709 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/30 (20190201) Original (OR) Class Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/20 (20190201) G16C 20/50 (20190201) Electric Discharge Tubes or Discharge Lamps H01J 49/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187838 | Brock |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Walker Brock (San Diego, California) |
| ABSTRACT | A blade antenna comprising: an upper blade element made of conductive, planar material having a profile that curves upwardly from a centrally-located feed point; and a lower blade element made of conductive, planar material having a profile that curves downwardly from the feed point, wherein the lower blade element is configured to be connected to a ground and has a thickness that is at least three times a thickness of the upper blade element, and wherein the curved profiles of the upper and lower blade elements are disposed with respect to one another so as to form a tapered slot on each side of the feed point. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546415 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/42 (20130101) H01Q 13/085 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187976 | Davlantes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Reach Power, Inc. (Redwood City, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Joseph Davlantes (Redwood City, California); Varun Ramaswamy (Redwood City, California) |
| ABSTRACT | A system for wireless power networking, preferably including one or more nodes, such as transmit nodes, receive nodes, relay nodes, and/or hybrid nodes. The system may function to form a power network (e.g., mesh network) configured to transfer power wirelessly between nodes of the system. A method for wireless power networking, preferably including transmitting power, controlling relay nodes, and/or receiving power, and optionally including optimizing power network operation. The method is preferably performed at (e.g., by one or more nodes of) the system, but can additionally or alternatively be performed by any other suitable system(s). |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/108312 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/005 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/23 (20160201) Original (OR) Class H02J 50/50 (20160201) Transmission H04B 7/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230188553 | Wee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Colin Wee (Columbus, Ohio); Ian LoVerde (Centreville, Virginia); Douglas A. Thornton (Columbus, Ohio) |
| ABSTRACT | CAN bus signal format inference includes: extracting candidate signals from training CAN bus message traffic; defining one or more signals, each signal being a candidate signal that matches structural characteristics of a matching data type and each signal being assigned the matching data type; and generating an inferred CAN bus protocol with which the defined one or more signals conform. Signals are extracted from CAN bus message traffic using the inferred CAN bus protocol, an anomaly in an extracted signal is detected, and an alert is generated indicating the detected anomaly. In another aspect, a transport protocol (TP) signal is extracted and analyzed to determine a fraction of the TP signal that matches opcodes of a machine language instruction set, and an anomaly is detected based at least in part on the determined fraction exceeding an opcode anomaly threshold. |
| FILED | Wednesday, February 08, 2023 |
| APPL NO | 18/107237 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/572 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 12/40 (20130101) H04L 63/20 (20130101) H04L 63/166 (20130101) H04L 63/1425 (20130101) Original (OR) Class H04L 2012/40215 (20130101) H04L 2012/40273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230188565 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Xu Lin (Chicago, Illinois); Frederico Araujo (White Plains, New York); Teryl Paul Taylor (Danbury, Connecticut) |
| ABSTRACT | A method of detecting deceptive web activity is implemented in an intermediary located between a requesting client device, and a server that hosts a web application. Following a bootstrap phase used to generate a database of information identifying characteristics of clients, the method begins by receiving a page directed to the client from the server. The server injects an invisible DOM element having a set of style properties associated therewith, with one of the set of style properties assigned a random value, to generate a modified page, which is returned to the client. As the client interacts with the modified page, the intermediary tracks the device's styles and uses them to identify the client from information in the database. Once the device is identified, the intermediary then detects whether a spoofing attack has occurred. By leveraging the tracked styles, a spoofing attack on the DOM element's styles may also be detected. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/551563 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/958 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1483 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230189530 | KHAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (ATLANTA, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ASIF KHAN (ATLANTA, Georgia); WINSTON CHERN (CAMBRIDGE, Massachusetts); YUAN-CHUN LUO (ATLANTA, Georgia); NUJHAT TASNEEM (ATLANTA, Georgia); ZHENG WANG (MERIDIAN, Idaho); SHIMENG YU (MARIETTA, Georgia) |
| ABSTRACT | A method of writing data to a Ferroelectric-FET (FeFET) based non-volatile memory device can be provided by applying a voltage pulse at a write voltage level with a write polarity at a gate electrode of a FeFET device with reference to a source electrode of the FeFET device, as a write operation to the FeFET device to establish a state for the FeFET device, changing the voltage pulse, directly after the write operation, to a non-zero bias voltage level with a bias polarity that is opposite to the write polarity, at the gate electrode with reference to the source electrode for a delay time to reduce neutralization of a trap state associated with the write operation of the FeFET device, and changing the voltage pulse, after the delay time, to a read voltage level as a read operation to the FeFET device to determine the state of the FeFET device established during the write operation. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063297 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/11502 (20130101) Original (OR) Class H01L 29/516 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230182038 | BURNS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan D. BURNS (College Station, Texas); Evgeny E. TERESHATOV (College Station, Texas); Lauren A. MCINTOSH (College Station, Texas); Gabriel C. TABACARU (College Station, Texas); Sherry J. YENNELLO (College Station, Texas) |
| ABSTRACT | A process for isolating astatine includes (a) contacting a composition comprising astatine and bismuth with nitric acid to form a first solution comprising astatine, bismuth, and nitric acid; (b) contacting a resin with the first solution so that astatine partitions out of the first solution and into the resin; and (c) eluting astatine from the resin. A composition comprising astatine may be of the formula AtO+X−, wherein X− is a counterion. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/995145 |
| CURRENT CPC | Separation B01D 15/12 (20130101) Original (OR) Class B01D 15/426 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/28026 (20130101) Non-metallic Elements; Compounds Thereof; C01B 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182086 | HO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | W.S. Winston HO (Columbus, Ohio); Ruizhi PANG (Columbus, Ohio); Ting-Yu CHEN (Worthington, Ohio) |
| ABSTRACT | Provided herein are gas permeable membranes comprising an amine-containing selective layer on top of a gas permeable polymer support as well as methods of making and using thereof. The membranes are useful for the separation of CO2 from N2-containing gases. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/926473 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 69/02 (20130101) B01D 69/1214 (20220801) Original (OR) Class B01D 71/60 (20130101) B01D 2325/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182089 | HO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | W.S. Winston HO (Columbus, Ohio); Yang HAN (Columbus, Ohio) |
| ABSTRACT | Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membrane can include a support layer, and a selective polymer layer disposed on the support layer. The selective polymer layer can include a selective polymer matrix (e.g., hydrophilic polymer, a cross-linking agent, an amino compound, a CO2-philic ether, or a combination thereof), and optionally graphene oxide dispersed within the selective polymer matrix. The membranes can be used to separate carbon dioxide from hydrogen. Also provided are methods of purifying syngas using the membranes described herein. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/926471 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 69/10 (20130101) B01D 69/148 (20130101) Original (OR) Class B01D 71/0211 (20220801) B01D 71/381 (20220801) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/205 (20130101) B01J 20/267 (20130101) B01J 20/28033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182094 | Kessler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Daniel S. Kessler (Stilwell, Kansas); Troy W. Leonard (Lee's Summit, Missouri) |
| ABSTRACT | A method for mixing, milling, and coating a plurality of constituents comprises placing the constituents in a container that includes a cylindrical inner surface; applying a first vibration to the container such that a motion of the vibration is parallel to a longitudinal axis of the container; and applying a second vibration to the container such that the motion of the vibration is not parallel to the longitudinal axis of the container. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/549972 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 31/50 (20220101) Original (OR) Class B01F 35/422 (20220101) Apparatus for Applying Fluent Materials to Surfaces, in General B05C 3/05 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182119 | Stamenkovic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Vojislav Stamenkovic (Naperville, Illinois); Rongyue Wang (Naperville, Illinois); Dusan Strmcnik (Woodridge, Illinois) |
| ABSTRACT | A synthesis process for forming nanodendrites. The nanodendrites are utilized in a process to form a heterojunction catalyst. Nanodendrites may include PtRu8 nanodendrites that can be oxidized through annealing to form PtRuO2. One heterojunction catalyst comprises PtRuO2 on a carbon support. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/104100 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/56 (20130101) Original (OR) Class B01J 37/04 (20130101) B01J 37/08 (20130101) B01J 37/009 (20130101) B01J 2523/821 (20130101) B01J 2523/828 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182235 | Penny et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Wade Penny (Cambridge, Massachusetts); Anastasios John Hart (Waban, Massachusetts) |
| ABSTRACT | Systems, devices, and methods for additive manufacturing are provided that allow for components being manufactured to be assessed during the printing process. As a result, changes to a print plan can be considered, made, and implemented during the printing process. More particularly, in exemplary embodiments, a spectrometer is operated while a component is being printed to measure one or more parameters associated with one or more layers of the component being printed. The measured parameter(s) are then relied upon to determine if any changes are needed to the way printing is occurring, and if such changes are desirable, the system is able to implement such changes during the printing process. By way of non-limiting examples, printed material in one or more layers may be reheated to alter the printed component, such as to remove defects identified by the spectrometer data. A variety of systems, devices, and methods for performing real-time sensing and control of an additive manufacturing process are also provided. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/070151 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/032 (20130101) B23K 26/70 (20151001) B23K 26/073 (20130101) B23K 26/342 (20151001) Original (OR) Class B23K 26/0622 (20151001) B23K 26/0626 (20130101) B23K 26/0821 (20151001) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/30 (20170801) B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/95 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182267 | Busenitz |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Clark Andrew Busenitz (Kansas City, Missouri) |
| ABSTRACT | A gripping device comprises a first arm, a second arm, and a tip. The second arm opposes at least a portion of the first arm and has a proximal end and a distal end operable to shift toward the first arm. The tip is shiftably coupled to the distal end of the second arm so that the tip is operable to longitudinally shift between a retracted position in which the tip is relatively closer to the proximal end of the second arm and an extended position in which the tip is relatively farther from the proximal end of the second arm. The tip enables a user to engage an object and shift so that the object can be rotated while held by the gripping device. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/079530 |
| CURRENT CPC | Tools or Bench Devices Not Otherwise Provided For, for Fastening, Connecting, Disengaging or Holding B25B 9/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182310 | Marvi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamidreza Marvi (Tempe, Arizona); Ehsan Dehghan-Niri (Las Cruces, New Mexico); Mahdi Ilami (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Hamidreza Marvi (Tempe, Arizona); Ehsan Dehghan-Niri (Las Cruces, New Mexico); Mahdi Ilami (Tempe, Arizona) |
| ABSTRACT | Various embodiments of a bio-inspired robot operable for detecting crack and corrosion defects in tubular structures are disclosed herein. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 18/055712 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1664 (20130101) B25J 9/1694 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182605 | HAFIZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hitachi Energy Switzerland AG (Baden, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Faeza HAFIZ (Raleigh, North Carolina); Dmitry ISHCHENKO (Cary, North Carolina) |
| ABSTRACT | Network constraint energy management system for electric vehicle (EV) depot charging and scheduling. In an embodiment, a power schedule is received from an economic dispatch application for a charging depot comprising EV charging station(s) and distributed energy resource(s). The power schedule may be simulated on a distribution network model of the charging depot, according to load flow analysis, to determine whether any grid-code violations occur. In response to the detection of violation(s), a constraint may be generated for each violating node, and the economic dispatch application may be re-executed with the constraint(s) to produce a new power schedule, until no violations are detected. When not all load demand can be satisfied by the power schedule, a charging schedule may be adjusted to ensure that critical energy requirements are satisfied. The final power and charging schedules may be used to schedule and control power generation and charging in the charging depot. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/551502 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/63 (20190201) B60L 53/64 (20190201) Original (OR) Class B60L 53/65 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183079 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenglong Li (Knoxville, Tennessee); Meijun Li (Knoxville, Tennessee) |
| ABSTRACT | A metal-zeolite composition comprising: (i) a zeolite phase; and (ii) a metal, other than aluminum or silicon, nanoscopically dispersed throughout said zeolite phase, wherein, if agglomerations of said metal are present, the agglomerations have a size of no more than 1 micron, wherein the zeolite may be, for example, a dealuminated zeolite, and the metal may be selected from transition metals, main group metals, and lanthanide metals. Also described herein is a method for producing the metal-zeolite composition in which a zeolite phase and metal salt are mixed and ground by a solvent-less ball milling process to produce an initial mixture, and calcining the initial mixture to produce the metal-zeolite composition. Further described herein is a method for converting an oxygen-containing organic species to a hydrocarbon, the method comprising contacting the species with the above described metal-loaded zeolite catalyst at a temperature of at least 100° C. and up to 550° C. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/078195 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 39/06 (20130101) C01B 39/38 (20130101) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 1/20 (20130101) C07C 2529/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183103 | Rassoolkhani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PowerTech Water, Inc. (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan Rassoolkhani (Lexington, Kentucky); James Landon (Lexington, Kentucky); Bradley Nightengale (Lexington, Kentucky); Elliott Rushing (Lexington, Kentucky); Cassie Roberts (Lexington, Kentucky); Cameron Lippert (Lexington, Kentucky) |
| ABSTRACT | A method for removing a metal from a carbonaceous electrode includes providing a regeneration solution that includes an acid, an oxidizing agent, or a combination thereof. The method further includes applying the regeneration solution to the carbonaceous electrode, and oxidizing the metal on the surface of the carbonaceous electrode. The method also includes collecting the oxidized metal in the regeneration solution. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/078373 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/46109 (20130101) Original (OR) Class C02F 2001/46119 (20130101) C02F 2001/46133 (20130101) C02F 2101/20 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 13/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183139 | Agarwal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arvind Agarwal (Miami, Florida); Ambreen Nisar (Miami, Florida); Tony Thomas (Miami, Florida); Kazue Orikasa (Miami, Florida); Benjamin Peter Boesl (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Arvind Agarwal (Miami, Florida); Ambreen Nisar (Miami, Florida); Tony Thomas (Miami, Florida); Kazue Orikasa (Miami, Florida); Benjamin Peter Boesl (Miami, Florida) |
| ABSTRACT | Ultra-high temperature carbide (UHTC) foams and methods of fabricating and using the same are provided. The UHTC foams are produced in a three-step process, including UHTC slurry preparation, freeze-drying, and spark plasma sintering (SPS). The fabrication methods allow for the production of any kind of single- or multi-component UHTC foam, while also providing flexibility in the shape and size of the UHTC foams to produce near-net-shape components. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/932819 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/14 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/5607 (20130101) C04B 35/5622 (20130101) Original (OR) Class C04B 35/6263 (20130101) C04B 35/6264 (20130101) C04B 35/62655 (20130101) C04B 35/63424 (20130101) C04B 38/0038 (20130101) C04B 38/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183448 | Hart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nanocomp Technologies, Inc. (The Woodlands, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashley Hart (Merimack, New Hampshire); Eitan ZEIRA (Merimack, New Hampshire); Geoff ROLLINS (Merimack, New Hampshire) |
| ABSTRACT | The present disclosure provides a polymer blend that includes at least two polymers which are immiscible to one another and a carbon nanotube pulp comprising entangled carbon nanotubes as a compatibilizing agent and to a method of preparing the same. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/925454 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/201 (20130101) C08J 3/226 (20130101) C08J 2323/06 (20130101) C08J 2367/02 (20130101) C08J 2423/06 (20130101) C08J 2467/02 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) Original (OR) Class C08K 9/00 (20130101) C08K 2201/001 (20130101) C08K 2201/003 (20130101) C08K 2201/004 (20130101) C08K 2201/006 (20130101) C08K 2201/011 (20130101) C08K 2201/016 (20130101) Compositions of Macromolecular Compounds C08L 23/06 (20130101) C08L 67/02 (20130101) C08L 2203/30 (20130101) C08L 2207/066 (20130101) C08L 2310/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183757 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Shuai Li (Durham, North Carolina) |
| ABSTRACT | The present disclosure is related to genetically engineered microbial strains and related bioprocesses for the production of xylitol. Specifically, the use of dynamically controlled synthetic metabolic valves to reduce the activity of certain enzymes, leads to increased xylitol production in a two-stage process. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/995360 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/90 (20130101) C12N 15/70 (20130101) C12N 15/113 (20130101) C12N 2500/34 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/18 (20130101) Original (OR) Class Enzymes C12Y 101/01049 (20130101) C12Y 101/01307 (20130101) C12Y 103/0101 (20130101) C12Y 503/01005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183759 | Pfleger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Brian F. Pfleger (Madison, Wisconsin); Qiang Yan (Madison, Wisconsin); Trevor R. Simmons (Austin, Texas); Nestor Hernandez-Lozada (Jena, Germany) |
| ABSTRACT | Recombinant cells and methods for producing methyl ketones, such as medium-chain methyl ketones. The recombinant cells include recombinant acyl-ACP thioesterase genes, recombinant β-ketoacyl-CoA thioesterase genes, and recombinant acyl-CoA synthetase genes, in addition to other modifications. The methods include culturing the recombinant cells to produce the methyl ketones and isolating the produced methyl ketones. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/926487 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/16 (20130101) C12N 9/93 (20130101) C12N 15/52 (20130101) C12N 15/74 (20130101) C12N 2330/50 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) Original (OR) Class Enzymes C12Y 101/01035 (20130101) C12Y 301/0202 (20130101) C12Y 301/02021 (20130101) C12Y 402/01017 (20130101) C12Y 602/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183882 | HSU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen M. HSU (Germantown, Maryland); Govindaiah PATAKAMURI (Ashburn, Virginia) |
| ABSTRACT | A method of forming a surface texture includes arranging a flexible mask (610, 920) with a pattern over a surface (621) of a component (620); and performing electrochemical etching on the surface (621) of the component (620) to form a surface texture on the surface (621) according to the pattern of the flexible mask. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/924907 |
| CURRENT CPC | Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/06 (20130101) C25F 3/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184209 | MENDOZA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Renee MENDOZA (Longmont, Colorado); Nicholas Aaron JOHNSON (Golden, Colorado); Derek Stephen BERRY (Broomfield, Colorado) |
| ABSTRACT | Among other things, the present disclosure relates to a wind turbine rotor blade that can be assembled at the site of its wind turbine. The blade includes an internal structure which may be pre-fabricated with connections to the shell skin prior to being transported to the site of its wind turbine. A filler material may be injected into the layers of fabric making up the shell skin at the wind turbine site and allowed to harden at approximately atmospheric conditions. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066371 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/48 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/085 (20130101) Wind Motors F03D 1/0675 (20130101) Original (OR) Class Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2230/20 (20130101) F05B 2230/90 (20130101) F05B 2280/6001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184464 | STEGALL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SOLAR DYNAMICS LLC (Broomfield, Colorado) |
| ASSIGNEE(S) | SOLAR DYNAMICS LLC (Broomfield, Colorado) |
| INVENTOR(S) | Nathaniel STEGALL (Broomfield, Colorado); Kyle KATTKE (Broomfield, Colorado); Rick SOMMERS (Broomfield, Colorado) |
| ABSTRACT | A mounting system for a heliostat is provided that allows the heliostat to move with respect to two orthogonal axes to track the sun. The mounting system has features that allow the heliostat to precisely and accurately move about these axes even as various components degrade during operation in harsh environments and over long time periods. Embodiments of the mounting system can have a frame that supports multiple mirrors and translates forces from the mirrors to multiple hubs that move about a circular track. One of the hubs can include a fewer number of contact points to accommodate a circular track that is out of round. In addition, an actuator that moves the hubs around the circular track can be biased into the track to also accommodate a circular track that is out of round. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/924729 |
| CURRENT CPC | Solar Heat Collectors; Solar Heat Systems F24S 23/70 (20180501) F24S 30/452 (20180501) Original (OR) Class F24S 2030/134 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184695 | Klein |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| ASSIGNEE(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| INVENTOR(S) | Marian Klein (Boulder, Colorado) |
| ABSTRACT | A system for passive microwave remote sensing using at least one microwave radiometer includes a fixed body portion, the fixed body portion being configured to attach to a mobile platform, and a mobile body portion, the mobile body portion being configured for rotatably coupling with the fixed body portion for rotation about a rotation axis. The mobile body portion is configured for supporting the at least one microwave radiometer therein such that the at least one microwave radiometer rotates about the rotation axis when the mobile body portion is rotated about the rotation axis such that a polarization axis of the at least one radiometer is aligned with an earth axis. The fixed body portion includes a motor mechanism for effecting rotation of the mobile body portion such that the at least one microwave radiometer provides a vertical scanning below and above the mobile platform. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/085710 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/00 (20130101) G01N 22/04 (20130101) Original (OR) Class G01N 33/2823 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 27/04 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184880 | Hughes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Michael S. Hughes (Richland, Washington); Eric G. Gonzalez (Richland, Washington) |
| ABSTRACT | Waveform emission location determination systems and associated methods are described. According to one aspect, a waveform emission location determination system includes a plurality of detectors configured to receive a waveform emitted by a source and to generate electrical signals corresponding to the waveform, processing circuitry configured to access data corresponding to the electrical signals generated by the detectors, use the data to determine a plurality of spheres, and wherein a surface of each of the spheres contains a location of the source when the waveform was emitted by the source, determine an intersection of the spheres, and use the intersection of the spheres to determine the location of the source when the waveform was emitted by the source. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/547665 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/22 (20130101) Original (OR) Class Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 13/1672 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230185607 | GUTIERREZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ADVANCED MICRO DEVICES, INC. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony GUTIERREZ (Bellevue, Washington); Sooraj PUTHOOR (Austin, Texas) |
| ABSTRACT | A processor core is configured to execute a parent task that is described by a data structure stored in a memory. A coprocessor is configured to dispatch a child task to the at least one processor core in response to the coprocessor receiving a request from the parent task concurrently with the parent task executing on the at least one processor core. In some cases, the parent task registers the child task in a task pool and the child task is a future task that is configured to monitor a completion object and enqueue another task associated with the future task in response to detecting the completion object. The future task is configured to self-enqueue by adding a continuation future task to a continuation queue for subsequent execution in response to the future task failing to detect the completion object. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993490 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/542 (20130101) G06F 9/545 (20130101) G06F 9/546 (20130101) G06F 9/3877 (20130101) G06F 9/4881 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230186057 | MUSAELIAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert MUSAELIAN (Cambridge, Massachusetts); Simon BATZNER (Cambridge, Massachusetts); Boris KOZINSKY (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure presents a method for determining a physical probability, wherein the method for determining a physical probability of a particle includes obtaining, by a computing device, a spatial input of a particle, identifying by the computing device, at least a tensor element as a function of the spatial input, and determining, by the computing device, the physical probability as a function of the element using a tensor machine learning model, wherein the tensor machine learning model is trained as a function of a tensor training set that correlates a plurality of tensor elements to a plurality of physical probabilities. This disclosure also presents a method for simulating molecular dynamics, wherein the method comprises accelerating, by a computing device, a computation associated with a force of a particle. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/060901 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/047 (20230101) Original (OR) Class G06N 3/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230186615 | Cook et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam W. Cook (Albuquerque, New Mexico); Devin John Roach (Albuquerque, New Mexico); William Reinholtz (Albuquerque, New Mexico); Robert Bernstein (Albuquerque, New Mexico) |
| ABSTRACT | A novel method can determine the mechanical properties of additively manufactured structures using artificial neural network and computer vision models. Using this methodology, simulation times can be dramatically reduced, allowing for the implementation of a genetic algorithm which can determine the optimal AM parameters to achieve a targeted mechanical response. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/548746 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) Computer Systems Based on Specific Computational Models G06N 3/12 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) Original (OR) Class G06V 10/774 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187113 | Prager et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Eagle Harbor Technologies, Inc. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Prager (Seattle, Washington); Kenneth Miller (Seattle, Washington); Kevin Muggli (Mountlake Terrace, Washington); Zach Mulalley (Seattle, Washington); Caleb Schmidt (Eatonville, Washington); Steven Wilson (Seattle, Washington); Huatsern Yeager (Olympia, Washington) |
| ABSTRACT | A high voltage inductive adder is disclosed. An inductive adder may include a plurality of switch boards that each include a plurality of switch boards that include a plurality of solid state switches. These switch boards may be stacked one upon another. The inductive adder may include a transformer comprising a plurality of toroid-shaped transformer cores disposed on a corresponding one of the plurality of switch boards; and a transformer rod that extends through the plurality of switch boards and the plurality of transformer cores. The inductive adder may include an output electrically coupled with the transformer rod. And each of the plurality of circuit boards, for example, may include a tailbiter circuit electrically coupled in parallel with the output. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/066277 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/24 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0243 (20130101) H05K 2201/1003 (20130101) H05K 2201/10022 (20130101) H05K 2201/10166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187615 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Kyu-Young Park (Evanston, Illinois) |
| ABSTRACT | A method for fabricating a composite material includes forming an emulsion mixture of active material particles and graphene emulsion droplets containing immiscible first and second solvents and a solid-state emulsifier of graphene, wherein the first and second solvents are adapted such that the second solvent resides in an interior of the graphene emulsion droplets with the first solvent as an exterior solvent, and the active material particles reside in the interior of the emulsion droplets; wherein a boiling point of the second solvent is lower than that of the first solvent; and drying the emulsion mixture with subsequent evaporation of the second solvent and the first solvent through fractional distillation to form the composite material having each surface of the active material particles conformally coated with said graphene. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/919592 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/42 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/52 (20130101) C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2002/85 (20130101) C01P 2002/88 (20130101) C01P 2004/02 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2004/80 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) Original (OR) Class H01M 4/525 (20130101) H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187674 | BUKOLA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saheed Abidemi BUKOLA (Longmont, Colorado); Bryan Scott PIVOVAR (Arvada, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes a first layer that includes a polymer having a repeat unit with a structure that includes where m is between 2 and 100, inclusively, the repeat unit is protonated at at least one of position A) and/or B) and/or sulfonated at at least one of rings 1) and/or 2), R1 includes at least one of a lone pair of electrons, a covalent bond, hydrogen, and/or a hydrocarbon functional group, R2 includes at least one of a lone pair of electrons, a covalent bond, hydrogen, and/or a hydrocarbon functional group, and |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/065896 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/18 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2281 (20130101) C08J 5/2287 (20130101) C08J 2351/08 (20130101) C08J 2379/04 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/103 (20130101) H01M 8/106 (20130101) H01M 8/188 (20130101) H01M 8/1039 (20130101) H01M 8/1053 (20130101) Original (OR) Class H01M 8/1067 (20130101) H01M 8/1088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187686 | Prasher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravi Prasher (Danville, California); Sumanjeet Kaur (Pinole, California); Gao Liu (Piedmont, California); Christopher Dames (Berkeley, California); Jonathan Lau (Fremont, California); Drew Lilley (Berkeley, California); Piyachai Khomein (San Bruno, California); Joseph Papp (Martinez, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to thermal energy storage with phase change materials having an adjustable transition temperature. In one aspect, a method includes providing a device. The devices includes a phase change material, a salt dissolved in the phase change material, and an anode and a cathode disposed in the phase change material. The phase change material changes from a solid to a liquid at a first temperature when the salt is dissolved in the phase change material. A voltage is applied to the anode and the cathode to substantially remove the salt from the phase change material. The phase change material changes from the solid to the liquid at a second temperature when the salt is substantially removed from the phase change material, with the first temperature being a lower temperature than the second temperature. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/898550 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) H01M 4/485 (20130101) H01M 4/583 (20130101) H01M 4/608 (20130101) H01M 10/052 (20130101) H01M 10/056 (20130101) Original (OR) Class H01M 50/46 (20210101) H01M 50/417 (20210101) H01M 50/426 (20210101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187697 | Cao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Xia Cao (Richland, Washington); Ji-Guang Zhang (Richland, Washington); Wu Xu (Richland, Washington) |
| ABSTRACT | Localized superconcentrated electrolytes (LSEs) and electrochemical devices including the LSEs are disclosed. The LSE includes an active salt, a solvent in which the active salt is soluble, and a diluent in which the active salt is insoluble or poorly soluble, wherein the diluent includes a fluorinated orthoformate. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/163679 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2300/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187923 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Fei Lu (Wynnewood, Pennsylvania); Hua Zhang (Philadelphia, Pennsylvania); Reza Kheirollahi (Philadelphia, Pennsylvania); Yao Wang (Philadelphia, Pennsylvania); Shuyan Zhao (Philadelphia, Pennsylvania) |
| ABSTRACT | With the fasting growth of renewable energy resources and DC supplied loads, DC electrical systems have been increasingly received attentions all over the world. DC breaker systems play a key role in protection systems for disconnecting sources and loads, and they are also used mainly for removing faulted sections from the system accurately and reliably. Solid state DC breakers benefit from fast response time and compactness features; however, due to the lack of zero current realization and high-power losses, the reliability and efficiency of these devices is low. The system proposes a solid-state DC breaker for medium voltage DC (MVDC) systems. The presented structure have two main parts: 1) a main conduction branch including stacked MV Silicon-Carbide (SiC) devices to improve the efficiency and provide a fast response time, 2) a breaker branch including a wireless capacitive coupling to avoid metal-to-metal contact and increase the overall reliability, and also a modular current pulse power supply to realize zero-current switching. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/996088 |
| CURRENT CPC | Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 9/54 (20130101) Emergency Protective Circuit Arrangements H02H 3/087 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230181120 | HASSANTABAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Shayan HASSANTABAR (Ewing, New Jersey); Niraj K. JHA (Princeton, New Jersey) |
| ABSTRACT | According to various embodiments, a machine-learning based system for coronavirus detection is disclosed. The system includes one or more processors configured to interact with a plurality of wearable medical sensors (WMSs). The processors are configured to receive physiological data from the WMSs and questionnaire data from a user interface. The processors are further configured to train at least one neural network based on raw physiological data and questionnaire data augmented with synthetic data and subjected to a grow-and-prune paradigm to generate at least one coronavirus inference model. The processors are also configured to output a coronavirus-based decision by inputting the received physiological data and questionnaire data into the generated coronavirus inference model. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/923958 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0205 (20130101) A61B 5/0533 (20130101) A61B 5/7267 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 50/80 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181473 | Auer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Elektrofi, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason G. Auer (Weymouth, Massachusetts); Paul Brown (Boston, Massachusetts); Tyler L. Carter (Newburyport, Massachusetts); Chase Spenser Coffman (Newton, Massachusetts); Paul F. Herbert (Framingham, Massachusetts); James W. Ivey (Reading, Massachusetts); Moin Khwaja (Boston, Massachusetts); Lisa Liu (Somerville, Massachusetts); Sadiqua Shadbar (Allston, Massachusetts); Shankul Vartak (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to methods that enable the continuous formation of droplets and dehydration of droplets to provide pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled continuous droplet formation and dehydration that produce circular particles having low internal void spaces comprising bioactive therapeutic biologies. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/916618 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1617 (20130101) A61K 9/1623 (20130101) A61K 9/1652 (20130101) A61K 9/1694 (20130101) Original (OR) Class A61K 38/385 (20130101) A61K 39/3955 (20130101) A61K 41/17 (20200101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181793 | Ding et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaochu Ding (Ithaca, New York); Yadong Wang (Ithaca, New York) |
| ABSTRACT | Poly(glycerol sebacate) (PGS) polymers, which may be referred to as a functionalized poly(glycerol sebacate) polymers. The PGS polymers include pendant aliphatic carboxyl ate groups and/or pendant aryl carboxyl ate groups covalently bound to the glycerol group of the glycerol sebacate backbone of the polymer. Polymeric materials including a plurality of glycerol sebacate groups, where at least a portion of the individual glycerol sebacate groups have a pendant aliphatic carboxylate group and/or pendant aryl carboxyl ate group covalently bound to the glycerol group of the glycerol sebacate group. The PGS polymers or polymeric materials may be crosslinked PGS polymers or polymeric materials. The PGS polymers and polymeric materials may be made by post-polymerization functionalization. The PGS polymers and polymeric materials may be in fiber form. A material, which may be a fabric, may include a fiber or plurality of fibers. A material may be used to form a tissue graft. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/923679 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/507 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/16 (20130101) C08G 63/916 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182091 | Lounder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel J. Lounder (Medford, Massachusetts); Ayse Asatekin Alexiou (Arlington, Massachusetts) |
| ABSTRACT | Disclosed are copolymers, comprising a plurality of zwitterionic repeat units, and a plurality of hydrophobic repeat units, wherein the hydrophobic repeat units each independently comprises a cross-linkable moiety; the cross-linked copolymer network, comprising such copolymer; as well as thin film composite membrane comprising such cross-linked copolymer network. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/924753 |
| CURRENT CPC | Separation B01D 69/02 (20130101) B01D 69/125 (20130101) B01D 71/82 (20130101) Original (OR) Class B01D 2323/30 (20130101) B01D 2325/04 (20130101) B01D 2325/18 (20130101) B01D 2325/20 (20130101) B01D 2325/34 (20130101) B01D 2325/38 (20130101) B01D 2325/02831 (20220801) B01D 2325/02832 (20220801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182124 | Agblevor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Utah State University (Logan, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Foster Agblevor (Logan, Utah); Hossein Jahromi (Logan, Utah); Oleksandr Hietsoi (Logan, Utah); Shereen Hassan (Logan, Utah) |
| ABSTRACT | This disclosure relates to red mud compositions. This disclosure also relates to methods of making red mud compositions. This disclosure additionally relates to methods of using red mud compositions. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 17/989444 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 21/08 (20130101) B01J 21/20 (20130101) B01J 35/023 (20130101) B01J 35/1014 (20130101) B01J 37/08 (20130101) B01J 37/009 (20130101) B01J 37/18 (20130101) B01J 37/0045 (20130101) B01J 37/0072 (20130101) Original (OR) Class B01J 37/0221 (20130101) B01J 38/10 (20130101) B01J 2523/22 (20130101) B01J 2523/847 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 3/44 (20130101) C10G 3/62 (20130101) C10G 2300/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182137 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheng Sun (Evanston, Illinois); Hao Zhang (Evanston, Illinois) |
| ABSTRACT | A system for performing avidity-based screening includes a microfluidic circuit that has an inlet designed to receive target cells and CAR-T cells that bind to the target cells. A light source illuminates a portion of the microfluidic circuit that includes the CAR-T cells such that photoacoustic pressure is applied to the CAR-T cells. An imaging sensor captures images of the CAR-T cells. A processor is configured to analyze the images to determine if a CAR-T cell has detached from a target cell. Responsive to a determination that the CAR-T cell has detached, the processor records an amount of the photoacoustic pressure applied to the CAR-T cell. A desired avidity is determined based on a photoacoustic force spectrum, which is based on a plurality of photoacoustic pressures applied to a plurality of detached CAR-T cells. The processor also extracts one or more CAR-T cells that exhibit the desired avidity. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080067 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502738 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/027 (20130101) B01L 2300/0816 (20130101) B01L 2300/0867 (20130101) B01L 2400/0487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182202 | WEI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei David WEI (Gainesville, Florida); Wenxiao GUO (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides for metal nanoparticles, such as gold nanoparticles that have six pointed areas so that the metal nanoparticle resembles a six-pointed star. The distance from opposing points of the six-pointed star is about 400 to 480 nanometers. The present disclosure also provides for a method of making the nanoparticle, where in an aspect, the method is a light-driven synthesis. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/926510 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/52 (20130101) B01J 23/72 (20130101) B01J 35/026 (20130101) B01J 37/344 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0553 (20220101) Original (OR) Class B22F 9/24 (20130101) B22F 2202/11 (20130101) B22F 2301/10 (20130101) B22F 2301/255 (20130101) B22F 2304/054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230182509 | Prabhakara et al. |
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| FUNDED BY |
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| APPLICANT(S) | Bridgestone Americas Tire Operations, LLC (Nashville, Tennessee); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Akarsh Prabhakara (Pittsburgh, Pennsylvania); Vaibhav Singh (Pittsburgh, Pennsylvania); Swarun Kumar (Pittsburgh, Pennsylvania); Anthony Rowe (Pittsburgh, Pennsylvania); Terence E. Wei (Copley, Ohio); Hans R. Dorfi (Akron, Ohio) |
| ABSTRACT | Tire sensing systems operable to determine one or more physical characteristics of a tire include millimeter wave transmitting and receiving devices. A processor is communicatively coupled with a memory that includes instructions to transmit and receive a millimeter wave toward and from the tire. Memory also includes instructions to image first and second radial extents of the tire based on the received millimeter wave as well as instructions to determine a dimensional difference between the first and second radial extents of the tire. Vehicles including such tire sensing systems as well as non-transitory machine-readable storage mediums and methods are also included. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/924647 |
| CURRENT CPC | Vehicle Tyres Tyre Inflation; Tyre Changing or Repairing; Repairing, or Connecting Valves To, Inflatable Elastic Bodies in General; Devices or Arrangements Related to Tyres B60C 11/243 (20130101) B60C 19/00 (20130101) Original (OR) Class B60C 2019/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183069 | Chanda et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Debashis Chanda (Orlando, Florida); Rinku Saran (Orlando, Florida) |
| ABSTRACT | A method of producing an organic non-wettable superhydrophobic fullerite film is presented. Non-wettable superhydrophobic fullerite films can be easily produced by growing nanofullerites via a sonication coupled crystallization protocol followed by multiple washings to obtain a pellet of nanofullerites. The pellet is aged for at least several weeks to allow for agglomeration into a gel which may then be applied to a substrate as a non-wettable superhydrophobic fullerite film. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 17/975051 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/154 (20170801) C01B 32/156 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183523 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Qixin Zhou (Copley, Ohio); Cheng Zhang (Lakewood, Colorado); Zichen Ling (Akron, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qixin Zhou (Copley, Ohio); Cheng Zhang (Lakewood, Colorado); Zichen Ling (Akron, Ohio) |
| ABSTRACT | A method of preparing a composition for a one-package (1 K) waterborne non isocyanate polyurethane epoxy hybrid coating includes providing a cyclic carbonate; combining the cyclic carbonate with an internal emulsifier and a diamine to thereby obtain a non-isocyanate polyurethane (NIPU) prepolymer; subjecting the NIPU prepolymer to chain extension by combining the NIPU prepolymer with an epoxy resin, to thereby obtain a chain extended NIPU polymer; subjecting the chain extended NIPU polymer to neutralization by combining the chain extended NIPU polymer with a neutralizing agent, to thereby obtain a neutralized NIPU polymer; and dispersing the neutralized NIPU polymer in water to thereby provide a waterborne NIPU liquid dispersion. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966145 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/245 (20130101) C08G 71/04 (20130101) C08G 2150/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 163/00 (20130101) C09D 175/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183643 | Azarin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Samira Azarin (Minneapolis, Minnesota); Casim A. Sarkar (Minneapolis, Minnesota); Kristen A. Lemke (Minneapolis, Minnesota) |
| ABSTRACT | Certain embodiments provide a method of producing a population of induced multipotent placental cells, the method comprising culturing a population of pluripotent stem cells in the presence of an induction media comprising a retinoid, and optionally a Wnt signaling agonist. Certain embodiments also provide cells, compositions, kits and methods of use thereof. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/948024 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0605 (20130101) Original (OR) Class C12N 2500/38 (20130101) C12N 2501/415 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183699 | Chilkoti et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh Chilkoti (Durham, North Carolina); Stefan Zauscher (Durham, North Carolina); Lei Tang (Durham, North Carolina); Sonal Deshpande (Durham, North Carolina) |
| ABSTRACT | Compositions and methods disclosed herein can help provide improved delivery of non-natural therapeutic nucleotides for the treatment of diseases such as cancer. An example composition includes an assembly of amphiphilic polynucleotides, where each amphiphilic polynucleotide includes an aptamer portion, a first nucleotide portion, and a second nucleotide portion. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051487 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 15/115 (20130101) C12N 2310/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183723 | GONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shaoqin GONG (Middleton, Wisconsin); Xuehua Zhong (Madison, Wisconsin); Yuyuan Wang (Madison, Wisconsin); Shuiming Qian (Madison, Wisconsin) |
| ABSTRACT | The present technology provides a nanoparticle that includes a silica network comprising crosslinked polysiloxanes, wherein the crosslinks comprise disulfide linkages, and the nanoparticle has a surface bearing charged functional groups and a surface potential of either less than −30 mV or greater than +30 mV, and wherein the nanoparticle has an average diameter of 20 nm to 60 n. The nanoparticles may be used to efficiently deliver biomolecules to plant cells, including polynucleic acids, proteins and complexes thereof (e.g., Cas9 RNP). |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/926113 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/392 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/8206 (20130101) Original (OR) Class C12N 15/8213 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183759 | Pfleger et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Brian F. Pfleger (Madison, Wisconsin); Qiang Yan (Madison, Wisconsin); Trevor R. Simmons (Austin, Texas); Nestor Hernandez-Lozada (Jena, Germany) |
| ABSTRACT | Recombinant cells and methods for producing methyl ketones, such as medium-chain methyl ketones. The recombinant cells include recombinant acyl-ACP thioesterase genes, recombinant β-ketoacyl-CoA thioesterase genes, and recombinant acyl-CoA synthetase genes, in addition to other modifications. The methods include culturing the recombinant cells to produce the methyl ketones and isolating the produced methyl ketones. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/926487 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/16 (20130101) C12N 9/93 (20130101) C12N 15/52 (20130101) C12N 15/74 (20130101) C12N 2330/50 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) Original (OR) Class Enzymes C12Y 101/01035 (20130101) C12Y 301/0202 (20130101) C12Y 301/02021 (20130101) C12Y 402/01017 (20130101) C12Y 602/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183823 | Gill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hunter Matthias Gill (Coatesville, Indiana); Sarath Chandra Janga (Carmel, Indiana); Quoseena Mir (Indianapolis, Indiana) |
| ABSTRACT | Disclosed are methods to characterize at least one vims in at least one human patient by (a) extracting a viral polynucleotide from a biological sample from the at least one human patient, (b) sequencing the viral polynucleotide to generate viral polynucleotide sequence data; and, (c) characterizing the viral polynucleotide sequence data. Further aspects of the invention may include a system which enables user to quickly and accurately search and/or add to data bases that facilitate the identification and/or treatment of diseases caused by viruses. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/997595 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/20022 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184695 | Klein |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| ASSIGNEE(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| INVENTOR(S) | Marian Klein (Boulder, Colorado) |
| ABSTRACT | A system for passive microwave remote sensing using at least one microwave radiometer includes a fixed body portion, the fixed body portion being configured to attach to a mobile platform, and a mobile body portion, the mobile body portion being configured for rotatably coupling with the fixed body portion for rotation about a rotation axis. The mobile body portion is configured for supporting the at least one microwave radiometer therein such that the at least one microwave radiometer rotates about the rotation axis when the mobile body portion is rotated about the rotation axis such that a polarization axis of the at least one radiometer is aligned with an earth axis. The fixed body portion includes a motor mechanism for effecting rotation of the mobile body portion such that the at least one microwave radiometer provides a vertical scanning below and above the mobile platform. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/085710 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/00 (20130101) G01N 22/04 (20130101) Original (OR) Class G01N 33/2823 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 27/04 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184997 | BALLATO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | URSULA GIBSON (HANOVER, New Hampshire); CLEMSON UNIVERSITY (CLEMSON, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOHN BALLATO (CLEMSON, South Carolina); THOMASINA ZAENGLE (CLEMSON, South Carolina); BARIS KUKUOZ (ANDERSON, South Carolina); URSULA GIBSON (HANOVER, New Hampshire) |
| ABSTRACT | Disclosed are methods for formation of a fiber and fibers that can be formed according to the methods. Formation methods incorporate a “molten core flux method” whereby a solid primary core material is combined with a solid secondary flux material in a multi-phase preform core. In some embodiments, the multi-phase preform core has a liquidus temperature that is reduced relative to the melting temperature of at least the primary core material. A homogeneous liquid melt of the preform core can exhibit a sufficiently low vapor pressure such that a fiber preform incorporating the materials in the core can be thermally drawn. Upon cooling and solidification of the homogeneous core melt, separation of the core components can occur via recrystallization, with one phase being that of the desired primary core material. Methods can be particularly beneficial for forming fibers incorporating high vapor pressure semiconductor materials, e.g., ZnSe or GaAs, in the fiber core. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/078156 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 27/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/02 (20130101) Original (OR) Class G02B 6/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230185003 | ZARZAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lauren Dell ZARZAR (University Park, Pennsylvania); Amy GOODLING (University Park, Pennsylvania); Caleb Meredith (Boalsburg, Pennsylvania) |
| ABSTRACT | Disclosed are methods of forming substrates which exhibit an interference pattern (e.g., structural color) upon reflection of incident electromagnetic radiation. Provided herein are methods for creating iridescent structural color with large angular spectral separation. The effect can be generated at interfaces with dimensions that are orders of magnitude larger than the wavelength of visible light. The structural color results from light interacting with the geometrical structure of an interface (e.g., a hemispheric/dome-shaped interface between two materials having different refractive indices) in a way that causes light interference. The structural color observed when viewing the surface depends upon the angle of the viewer as well as the angle of the light incident to the surface. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/926399 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/0074 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/378 (20141001) Optical Elements, Systems, or Apparatus G02B 5/13 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230185120 | Partee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Syght, Inc. (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles C. Partee (Golden, Colorado); Kevin D. McKinstry (Westminster, Colorado) |
| ABSTRACT | An optoelectronic system includes a concentration layer, a modulation layer including an array of light modulators, an exit layer that receives the modulation layer output having a modulation layer output spatial distribution and remaps the modulation layer output spatial distribution to a modified spatial distribution. A collector layer receives the modified spatial distribution to produce a collector layer output. A detector receives the collector layer output. A processor controls the modulation layer and receives the detector output to generate an image. The collector layer can receive the modified spatial distribution at a plurality of collector layer inputs and combine the plurality of collector layer inputs at a collector layer output. Modulators can be configured to direct couple modulated light to a collector layer, without using an exit layer. Configurations with spatial light modulator modules and sub-modules are described. |
| FILED | Friday, February 03, 2023 |
| APPL NO | 18/105665 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/0056 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/09 (20130101) Original (OR) Class G02F 1/092 (20130101) G02F 1/095 (20130101) G02F 2203/07 (20130101) G02F 2203/12 (20130101) Pictorial Communication, e.g Television H04N 9/3167 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187146 | Choi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jong Hyun Choi (West Lafayette, Indiana); Duncan Neal Houpt (San Francisco, California); Jaehoon Ji (West Lafayette, Indiana) |
| ABSTRACT | Ternary composite material, electrode, supercapacitor, and related methods. A ternary composite material includes a scaffold formed of carbon nanotubes (CNT), a first layer of zeolitic imidazolate 8 (ZIF-8) crystals formed on the scaffold of the CNT, and a second layer of molybdenum disulfide (MoS2) flakes formed on the first layer of the ZIF-8 crystals. An electrode can be formed with the ternary composite. A supercapacitor may include one or more electrodes that are at least partly formed of the ternary composite material. Methods of producing the ternary composite material and the electrodes are also disclosed. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/063998 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/16 (20170801) C01B 32/174 (20170801) C01B 2202/22 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2004/03 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/36 (20130101) Original (OR) Class H01G 11/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187167 | de Boer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maarten de Boer (Pittsburgh, Pennsylvania); Longchang Ni (Pittsburgh, Pennsylvania) |
| ABSTRACT | A micro-electromechanical system (MEMS) device includes a silicon substrate; and a Tantalum (Ta) layer comprising a first portion and a second portion, a first portion being suspended over the silicon substrate and configured to move relative to the silicon substrate, and the second portion of the structure being coupled to the silicon substrate and fixed in place relative to the silicon substrate. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/082543 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 7/0003 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/20 (20130101) Original (OR) Class H01J 2237/3151 (20130101) H01J 2237/20221 (20130101) H01J 2237/20264 (20130101) H01J 2237/20271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187615 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Kyu-Young Park (Evanston, Illinois) |
| ABSTRACT | A method for fabricating a composite material includes forming an emulsion mixture of active material particles and graphene emulsion droplets containing immiscible first and second solvents and a solid-state emulsifier of graphene, wherein the first and second solvents are adapted such that the second solvent resides in an interior of the graphene emulsion droplets with the first solvent as an exterior solvent, and the active material particles reside in the interior of the emulsion droplets; wherein a boiling point of the second solvent is lower than that of the first solvent; and drying the emulsion mixture with subsequent evaporation of the second solvent and the first solvent through fractional distillation to form the composite material having each surface of the active material particles conformally coated with said graphene. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/919592 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/42 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/52 (20130101) C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2002/85 (20130101) C01P 2002/88 (20130101) C01P 2004/02 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2004/80 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) Original (OR) Class H01M 4/525 (20130101) H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230180797 | TANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WASHINGTON STATE UNIVERSITY (Pullman, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juming TANG (PULLMAN, Washington); Franklin Loring YOUNCE (PULLMAN, Washington); Zhongwei TANG (Pullman, Washington); Fang LIU (PULLMAN, Washington) |
| ABSTRACT | Method and apparatus for industrial microwave (MW)-assisted thermal sterilization and pasteurization using solid-state MW generators. One or more phased array generators heat packaged foods or liquids conveyed in transport carriers through a processing liquid providing supplemental temperature control and hydrostatic pressure. Generator output signals are computer controlled, allowing phase and power-ratio modulation to both adjust interference patterns within heating cavities and shift focus of heating energy. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/999268 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 3/01 (20130101) Original (OR) Class A23L 3/02 (20130101) A23L 3/0155 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/80 (20130101) H05B 6/686 (20130101) H05B 6/701 (20130101) H05B 6/705 (20130101) H05B 6/782 (20130101) H05B 2206/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230181504 | Marini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan C. Marini (Houston, Texas); Sandesh Chakravarthy Sreenath Nagamani (Bellaire, Texas) |
| ABSTRACT | Embodiments of the disclosure include certain formulations for methods of treating urea cycle disorders. The methods encompass compositions that comprise benzoate and phenylbutyrate that may be at certain doses and have certain ratios of the components. The benzoate and phenylbutyrate may act synergistically in treatment of the urea cycle disorders, in particular embodiments. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 18/056231 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/216 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183141 | Cai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiyong Cai (Madison, Wisconsin); Qiangu Yan (Madison, Wisconsin) |
| ABSTRACT | Methods of forming a carbon fiber reinforced carbon foam are provided. Such a method may comprise heating a porous body composed of a solid material comprising covalently bound carbon atoms and heteroatoms and having a surface defining pores distributed throughout the solid material, in the presence of an added source of gaseous hydrocarbons. The heating generates free radicals in the porous body from the heteroatoms and induces reactions between the free radicals and the gaseous hydrocarbons to form covalently bound carbon nanofibers extending from the surface of the solid material and a network of entangled carbon microfibers within the pores the porous body, thereby forming a carbon fiber reinforced carbon foam. Carbon fiber reinforced carbon foams and ballistic barriers incorporating the foams are also provided. |
| FILED | Wednesday, February 08, 2023 |
| APPL NO | 18/107189 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/83 (20130101) Original (OR) Class C04B 38/0022 (20130101) C04B 2235/614 (20130101) C04B 2235/5248 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230183722 | XIONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WASHINGTON STATE UNIVERSITY (Pullman, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaochao XIONG (Pullman, Washington); Shulin CHEN (Pullman, Washington) |
| ABSTRACT | This invention discloses a novel system and method for expressing multiple gene products in oleaginous yeasts including Yarrowia lipolytica and Rhodotorula toruloides. More particularly, the present disclosure provides novel promoters functional in Y. lipolytica which can be used for producing a broad range of bioproducts. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/995624 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/48 (20130101) C12N 15/815 (20130101) Original (OR) Class C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230186210 | Asiabanpour et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TEXAS STATE UNIVERSITY (San Marcos, California) |
| ASSIGNEE(S) | TEXAS STATE UNIVERSITY (San Marcos, Texas) |
| INVENTOR(S) | Bahram Asiabanpour (San Marcos, Texas); Isaac Olson (San Marcos, Texas) |
| ABSTRACT | In some embodiments, the present disclosure pertains to methods and systems for optimizing a property of a plant. In some embodiments, the methods of the present disclosure include: (1) receiving one or more growth-related parameters of the plant; (2) receiving one or more phenotype-related parameters of the plant; (3) receiving one or more qualitative parameters of the plant; (4) utilizing a computing unit to evaluate said one or more growth-related parameters, phenotype-related parameters and qualitative parameters of the plant; and (5) utilizing the computing unit to adjust the one or more of the growth-related parameters of the plant based on the evaluation. In some embodiments, the aforementioned steps are repeated a plurality of times. In some embodiments, the parameters are stored in a database and utilized by a machine-learning algorithm to optimize the evaluation of the parameters and adjustment of the growth-related parameters. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 17/922301 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/02 (20130101) A01G 25/167 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) G06Q 10/06315 (20130101) Original (OR) Class G06Q 50/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230183569 | Van Loef et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Radiation Monitoring Devices, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | Radiation Monitoring Devices, Inc. (Watertown, Massachusetts) |
| INVENTOR(S) | Edgar V. Van Loef (Watertown, Massachusetts); Jaroslaw Glodo (Allston, Massachusetts); Pijush Bhattacharya (Watertown, Massachusetts); Lakshmi Soundara Pandian (Arlington, Massachusetts); Kanai S. Shah (Watertown, Massachusetts) |
| ABSTRACT | Halide-based scintillator materials, and related systems and methods are generally described. In some embodiments, the scintillator materials are thallium-based and/or have a perovskite structure. Specific embodiments of thallium calcium halides and thallium magnesium halides with desirable scintillation properties are provided. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880203 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/628 (20130101) C09K 11/7705 (20130101) Original (OR) Class Measurement of Nuclear or X-radiation G01T 1/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230186216 | Fortune et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | John Fortune (Clifton, Virginia); Brian Lewis (Washington, District of Columbia); Michelle Weinberger (Vienna, Virginia); Frank Cartwright (Rockville, Maryland) |
| ABSTRACT | A method includes receiving distributed sensing information on one or more characteristics associated with a subject from distributed sensors distributed between a starting location spaced from a resolution location and the resolution location. If the subject is sensed by the plurality of distributed sensors, in combination without any break in chain of custody (“COC”), the method does not adjust a reliability of the distributed sensing information caused by any break in COC. If there are one or more time gaps in the COC, the method determines one or more COC factors based on the time gaps and adjusts the reliability of the distributed sensing information based on the one or more COC factors. The method determines a trust score of the subject to assess security concern of the subject based on the distributed sensing information and the reliability thereof, and resolves the security concern based on the trust score. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106760 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0635 (20130101) Original (OR) Class G06Q 50/265 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230184783 | Shlipak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael George Shlipak (San Francisco, California); Michelle Estrella (San Francisco, California); Joachim H. lx (La Jolla, California); Rebecca Scherzer (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods of determining whether a subject treated for hypertension should continue hypertension treatment. In exemplary embodiments, the method comprises measuring the level of at least two of the following in a urine sample obtained from the subject: (i) Alpha—1 microglobulin (aim); (ii) kidney injury molecule (KIM—1); and (iii) Chitinase-3-like protein (YKL-40); wherein the subject should continue the hypertension treatment, when the levels are decreased or unchanged, relative to a control level, and wherein the subject should discontinue or decrease the hypertension treatment, when the levels are increased, relative to a control level. Related methods, kits, assay systems, systems comprising machine readable instructions, computer-readable storage media, and methods implemented by a processor in a computer are furthermore provided herein. |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/282854 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) Original (OR) Class G01N 2333/54 (20130101) G01N 2333/924 (20130101) G01N 2333/70578 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187064 | Pittman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Pittman (Washington, District of Columbia); Elizabeth Floto (Washington, District of Columbia); Niloofar Afari (Washington, District of Columbia) |
| ABSTRACT | Comprehensive patient-facing screening may provide diagnostics, real-time alerts, and feedback relating to a wide range of health and medical-related issues. The methods and systems for comprehensive patient-facing screening described provide feasible, user-friendly use, and may improve operations, processes, and connection to clinical care for users, such as veterans. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/924643 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 40/67 (20180101) Original (OR) Class G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 80/00 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230184695 | Klein |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| ASSIGNEE(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| INVENTOR(S) | Marian Klein (Boulder, Colorado) |
| ABSTRACT | A system for passive microwave remote sensing using at least one microwave radiometer includes a fixed body portion, the fixed body portion being configured to attach to a mobile platform, and a mobile body portion, the mobile body portion being configured for rotatably coupling with the fixed body portion for rotation about a rotation axis. The mobile body portion is configured for supporting the at least one microwave radiometer therein such that the at least one microwave radiometer rotates about the rotation axis when the mobile body portion is rotated about the rotation axis such that a polarization axis of the at least one radiometer is aligned with an earth axis. The fixed body portion includes a motor mechanism for effecting rotation of the mobile body portion such that the at least one microwave radiometer provides a vertical scanning below and above the mobile platform. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/085710 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/00 (20130101) G01N 22/04 (20130101) Original (OR) Class G01N 33/2823 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 27/04 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20230183523 | Zhou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Qixin Zhou (Copley, Ohio); Cheng Zhang (Lakewood, Colorado); Zichen Ling (Akron, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qixin Zhou (Copley, Ohio); Cheng Zhang (Lakewood, Colorado); Zichen Ling (Akron, Ohio) |
| ABSTRACT | A method of preparing a composition for a one-package (1 K) waterborne non isocyanate polyurethane epoxy hybrid coating includes providing a cyclic carbonate; combining the cyclic carbonate with an internal emulsifier and a diamine to thereby obtain a non-isocyanate polyurethane (NIPU) prepolymer; subjecting the NIPU prepolymer to chain extension by combining the NIPU prepolymer with an epoxy resin, to thereby obtain a chain extended NIPU polymer; subjecting the chain extended NIPU polymer to neutralization by combining the chain extended NIPU polymer with a neutralizing agent, to thereby obtain a neutralized NIPU polymer; and dispersing the neutralized NIPU polymer in water to thereby provide a waterborne NIPU liquid dispersion. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966145 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/245 (20130101) C08G 71/04 (20130101) C08G 2150/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 163/00 (20130101) C09D 175/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230182240 | Hall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shawn Hall (Pleasantville, New York); Robert Shelby (Boulder Creek, California); Charles Rettner (San Jose, California) |
| ABSTRACT | An apparatus comprising a first component comprised of a first material, wherein the first material has a first thermal contraction property. A second component comprised of a second material, wherein the second material has a second thermal contraction property, wherein the second component has an opening where a portion of the first component is inserted into at room temperature. Wherein the second thermal contraction property is larger than the first thermal contraction property and when at cryogenic temperatures, the first component and second component constrict, wherein the second component constricts more than the first component causing the second component to exert a constricting force on the portion of the first component inserted into the opening of the second component. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/644443 |
| CURRENT CPC | Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 11/025 (20130101) Original (OR) Class Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 1/00 (20130101) F16B 4/006 (20130101) F16B 2001/0078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184553 | MORRISON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GORDON BARBOUR MORRISON (Summerland, California); MICHAEL D. BULATOWICZ (Sun Prairie, Wisconsin); MICHAEL S. LARSEN (Woodland Hills, California); Bob Buckley (Goleta, California) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | GORDON BARBOUR MORRISON (Summerland, California); MICHAEL D. BULATOWICZ (Sun Prairie, Wisconsin); MICHAEL S. LARSEN (Woodland Hills, California); Bob Buckley (Goleta, California) |
| ABSTRACT | One example includes an atomic sensor system. The system includes an optical source configured to provide an optical beam and a plurality of sensor cell systems. Each of the sensor cell systems includes sensing media enclosed in a volume therein. The system also includes optics configured to provide the optical beam to each of the sensor cell systems to provide interaction of the optical beam with the vapor in each of the respective sensor cell systems. The optical beam exiting each of the sensor cell systems is a respective detection beam. The system further includes a detection system comprising at least one configured to receive the detection beam from each of the sensor cell systems and to determine a measurable parameter based on an optical characteristic associated with the detection beam from each of the sensor cell systems. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/074668 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230184950 | Greenberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Adam Hodge Greenberg (Gardenia, California); Eran Marcus (Culver City, California) |
| ABSTRACT | A plurality of scattered laser pulses is received, each scattered laser pulse associated with at least one plurality of respective dwells. A set of 3D velocity information is received, which is derived from photo events detected in information associated with the received plurality of scattered laser pulses. Each dwell in the plurality of dwells is associated with one or more photo events. The 3D velocity information comprises information estimating each respective photo event’s respective position in 6D space during the respective dwell associated with the photo event. For each dwell, its respective photo events are projected into a common reference frame, determined based on the 3D velocity information, to generate a set of motion-compensated point clouds. Each respective motion-compensated point cloud, for each dwell, is registered to the other motion-compensated point clouds in the set, to generate a set of registered point clouds, which are merged into a volumetric image. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/643511 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4814 (20130101) G01S 17/58 (20130101) G01S 17/89 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230186135 | Kumph et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Muir Kumph (Croton on Hudson, New York); Oliver Dial (Yorktown Heights, New York); John Blair (Tucson, Arizona) |
| ABSTRACT | An apparatus comprising a first qubit has a first driving frequency and a second qubit electrically connected to the first qubit, wherein the second qubit has a second driving frequency, wherein the second driving frequency is different than the first driving frequency. A readout resonator electrically connected to the first qubit and the second qubit and a filter electrically connected to the readout resonator, wherein the filter allows for the first qubit to be driven at the second driving frequency of the second qubit. A drive unit electrically connected to the filter. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/644424 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187355 | Carnevale et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Santino Carnevale (Yorktown Heights, New York); Wei Kong (Yorktown Heights, New York); Mary Beth Rothwell (Yorktown Heights, New York); Bryan Trimm (Yorktown Heights, New York); Brent Wascaser (Yorktown Heights, New York) |
| ABSTRACT | A method comprising forming a trench in a substrate and forming a first Ti layer on the top surface of the substrate, such that, the first Ti layer is formed on the exposed surface of the trench. Forming a Nb layer on an exposed top surface of first Ti layer and forming a second Ti layer on the exposed top surface of the Nb layer. Planarizing the second Ti layer, the Nb layer, and the first Ti layer to the top surface of the substrate, wherein the second Ti layer, the Nb layer, and the first Ti layer remain within the trench, wherein the Nb layer has at least two surfaces exposed during the planarizing process. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/644448 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/7684 (20130101) H01L 21/7685 (20130101) H01L 21/76877 (20130101) H01L 23/53285 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230187801 | Beck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Beck (Danbury, New York); John Bulzachelli (Somers, New York) |
| ABSTRACT | An embodiment of the invention may include a circuit structure. The circuit structure may include a wiring tree located between a feeding Josephson transmission line (FJTL) and a global bias line. The circuit may include the wiring tree having an H-tree structure, wherein each branch of the H-tree is connected by a current limiting junction of the FJTL, and wherein a single output port of the H-tree structure is connected to the global bias line. Another embodiment of the invention may include a circuit structure a circuit structure a plurality of feeding Josephson transmission lines (FJTLs) located between a feed line and a global bias line. The path of from the feed line through each FJTL and to the global bias line is substantially similar. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/644453 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230189426 | Kwark |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Young Kwark (Chappaqua, New York) |
| ABSTRACT | An attenuator comprising a first thermal reservoir and a first metal layer located on top of the first thermal reservoir. A first dielectric layer located on top of the first metal layer and a resistor located on top the first dielectric layer. A second dielectric layer located on top of the resistor and a second metal layer located on top of the second dielectric layer. A second thermal reservoir located on top the third metal layer and wherein the resistor is split or perforated by a thermal shunt, wherein the thermal shunt includes a thermal column that directs the heat generated by the resistor vertically upwards or downwards into the first and second thermal reservoirs, respectively. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/644431 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/225 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0201 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230189664 | Hervier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antoin Hervier (Yorktown Heights, New York); Oliver Dial (Yorktown Heights, New York); Ken Perez (Yorktown Heights, New York); Mary Beth Rothwell (Yorktown Heights, New York) |
| ABSTRACT | A method comprising forming capacitor pads for a qubit on a silicon wafer. Applying a resist layer on top of the capacitor pads. Pattern the resist layer to expose a portion of the capacitor pads. Utilizing an electron beam to remove the exposed portion of the capacitor. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/644447 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/2493 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, June 15, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
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FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230615.html
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