FedInvent™ Patent Applications
Application Details for Thursday, June 22, 2023
This page was updated on Friday, June 23, 2023 at 06:00 AM GMT
Department of Health and Human Services (HHS)
| US 20230190105 | HENRY et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| INVENTOR(S) | Thomas R. HENRY (Minneapolis, Minnesota); Gregory F. MOLNAR (Minneapolis, Minnesota); Michael C. PARK (Minneapolis, Minnesota); Pierre-Francois VAN DE MOORTELE (Minneapolis, Minnesota) |
| ABSTRACT | Ultra-high field (“UHF”) magnetic resonance imaging (“MRI”) is used to localize the endopiriform nucleus (“EPN”) as a target for neuromodulation treatment. Single or multiple different image contrasts can be used to guide localization of the EPN. Treatment plan data are generated based on the localized EPN, and may include coordinate data, trajectory data, or both, for delivering neuromodulation treatment to the localized EPN. |
| FILED | Monday, October 05, 2020 |
| APPL NO | 17/766420 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0036 (20180801) A61B 5/0042 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190129 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Wei Chen (Minneapolis, Minnesota); Guangle Zhang (Minneapolis, Minnesota); Wei Zhu (Minneapolis, Minnesota); Xiao-Hong Zhu (Minneapolis, Minnesota) |
| ABSTRACT | A system and method for performing magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), or magnetic resonance spectroscopy imaging (MRS I) at multiple resonant frequencies using a coil system. The coil system includes at least one conductive loop and a capacitor forming a radiofrequency (RF) resonant antenna and a tuning-matching circuit electrically connected to the RF resonant antenna to operate at multiple resonant frequencies across a desired operational range. The coil system also includes two legs electrically connecting the tuning-matching circuit to the RF resonant antenna and having a length selected to generate at least two selected resonant frequencies with a selected frequency difference. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/872793 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/055 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190379 | Ma et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guangshen Ma (Durham, North Carolina); Weston Ross (Durham, North Carolina); Patrick Codd (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes a method comprising ablating a substrate with a laser at an orientation to create a cavity in the substrate, scanning the cavity, and creating a three-dimensional surface for the cavity. The method further includes storing the three-dimensional surface in a dataset. The dataset includes a laser projected distance as an independent variable and a depth of cut as a dependent variable. The method further includes fitting parameters of a gaussian-based model for the laser and the substrate based on the dataset. The present disclosure also describes a method providing a pre-ablation surface, labeling a three-dimensional obstacle boundary that separates material to be remove by a laser and material to remain, and determining an orientation of the laser that results in a predicted post-ablation surface that does not intersect the three-dimension obstacle boundary. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/084777 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/20 (20130101) A61B 34/10 (20160201) Original (OR) Class A61B 34/30 (20160201) A61B 90/361 (20160201) A61B 2018/00577 (20130101) Image Data Processing or Generation, in General G06T 7/13 (20170101) G06T 7/70 (20170101) G06T 7/521 (20170101) G06T 11/005 (20130101) G06T 17/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190640 | Bhamla et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammed Saad Bhamla (Atlanta, Georgia); Gaurav Byagathvalli (Cumming, Georgia); Dengning Xia (Shanghai, China PRC); Mark R. Prausnitz (Atlanta, Georgia) |
| ABSTRACT | Devices and methods are provided for administering a drug to a biological tissue in a patient, such as by intracellular and/or dermal delivery. The device includes a piezoelectric pulse generator; and an array of microneedle electrodes electrically coupled to the piezoelectric pulse generator, wherein the device, following insertion of the microneedle electrodes into the biological tissue, is configured to generate and deliver one or more electrical pulses through the microneedle electrodes effective to electroporate cells in the biological tissue and enable delivery of a drug into the electroporated cells. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/924803 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) Original (OR) Class A61K 39/12 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) A61M 2037/0023 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0424 (20130101) A61N 1/0476 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190648 | Oklu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
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| INVENTOR(S) | Rahmi Oklu (Chandler, Arizona); Jingjie Hu (New York, New York) |
| ABSTRACT | This document provides materials and methods for permanent arterial embolization and/or enhanced vascular healing. For example, materials and methods for using bioactive tissue derived nanocomposite hydrogels to enhance vascular healing are provided. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/925520 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) Original (OR) Class A61K 9/0024 (20130101) A61K 47/02 (20130101) A61K 47/46 (20130101) A61K 49/0438 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/001 (20130101) A61L 24/0005 (20130101) A61L 24/0031 (20130101) A61L 24/0068 (20130101) A61L 2300/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190650 | Jay et al. |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
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| INVENTOR(S) | Michael Jay (Chapel Hill, North Carolina); Ben Zeldes (ChapelHill, North Carolina); Jesse Martin (Chapel Hill, North Carolina); Stephen McMillan (Chapel Hill, North Carolina) |
| ABSTRACT | In view of the health and addiction risks associated with opiates, anesthetic emulsions are described herein comprising eutectic mixtures of local anesthetics. In some embodiments, the anesthetic emulsions release one or more local anesthetics over a period of several days for continuous pain relief. An anesthetic emulsion, in some embodiments, comprises a dispersed phase comprising a eutectic mixture of lidocaine and benzocaine, and an aqueous or aqueous- based continuous phase comprising bupivacaine. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/801705 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/006 (20130101) A61K 9/107 (20130101) Original (OR) Class A61K 31/167 (20130101) A61K 31/245 (20130101) A61K 31/445 (20130101) A61K 47/10 (20130101) A61K 47/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190656 | Lai et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
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| INVENTOR(S) | Samuel K. Lai (Carrboro, North Carolina); Ming Yang (Towson, Maryland); Ying-Ying Wang (Baltimore, Maryland); Olcay Mert (Ankara, Turkey); Laura Ensign (Towson, Maryland); Justin Hanes (Baltimore, Maryland); Jie Fu (Baltimore, Maryland) |
| ABSTRACT | The present invention generally relates to reducing the mucoadhesive properties of a particle. In some embodiments, the particle is coated with and/or associated with a (poly(ethylene glycol))-(poly(propylene oxide))-(poly(ethylene glycol)) triblock copolymer. Methods for preparing inventive particles using a poly(ethylene glycol)-vitamin E conjugate as a surfactant are also provided. In some embodiments, methods are provided comprising administering to a subject a composition of particles of the present invention. Such particles with reduced mucoadhesive properties are useful in delivering agents to mucosal tissues such as oral, ophthalmic, gastrointestinal, nasal, respiratory, and genital mucosal tissues. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/096869 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 9/1641 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 31/355 (20130101) A61K 45/06 (20130101) A61K 47/60 (20170801) A61K 47/6935 (20170801) A61K 49/0002 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2998 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190663 | FERNANDES et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ROHAN FERNANDES (Bethesda, Maryland); PREETHI BALA BALAKRISHNAN (Arlington, Virginia); CARISSA STOVER (Silver Spring, Maryland); ALBERTO BOSQUE (Washington, District of Columbia); INDRA SARABIA (Washington, District of Columbia); ANVITHA SHRI RAMANUJAM (Fairfax, Virginia) |
| ABSTRACT | Embodiments of the instant disclosure relate to novel compositions and methods for the treatment of retroviruses (e.g., HIV) and the reduction and/or eradication of latent HIV reservoirs. Compositions herein may include biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with at least one biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950573 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5073 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190667 | Mao et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hai-Quan Mao (Baltimore, Maryland); Jose Luis Santos (Rockville, Maryland); Yong Ren (Baltimore, Maryland); John-Michael Williford (Chicago, Illinois) |
| ABSTRACT | The presently disclosed subject matter provides methods for continuously generating uniform polyelectrolyte complex (PEC) nanoparticles comprising: flowing a first stream comprising one or more water-soluble polycationic polymers at a first variable flow rate into a confined chamber; flowing a second stream comprising one or more water-soluble polyanionic polymers at a second variable flow rate into the confined chamber; and impinging the first stream and the second stream in the confined chamber until the Reynolds number is from about 1,000 to about 20,000, thereby causing the one or more water-soluble polycationic polymers and the one or more water-soluble polyanionic polymers to undergo a polyelectrolyte complexation process that continuously generates PEC nanoparticles. Compositions produced from the presently disclosed methods and a device for producing the compositions are also disclosed. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/165436 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5115 (20130101) A61K 9/5146 (20130101) A61K 9/5161 (20130101) A61K 9/5169 (20130101) A61K 9/5192 (20130101) Original (OR) Class A61K 47/61 (20170801) A61K 47/6455 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190692 | Cohen |
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| APPLICANT(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadeiphia, Pennsylvania) |
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| INVENTOR(S) | Akiva S. Cohen (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | Compositions and methods are provided for the alleviation of pathology induced by traumatic brain injury. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/109037 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/198 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190707 | Bradley et al. |
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| FUNDED BY |
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| APPLICANT(S) | FRED HUTCHINSON CANCER CENTER (Seattle, Washington); Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington); Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Robert K. Bradley (Seattle, Washington); Omar Abdel-Wahab (New York, New York); Sydney Lu (New York, New York) |
| ABSTRACT | The disclosure provides methods of enhancing susceptibility of neoplastic, transformed, and/or cancer cells (“cancer cells”) to immunotherapeutic agents. The methods comprise contacting the cancer cell with an agent that modulates RNA splicing. In some embodiments, the method further comprise contacting the cancer cell with the immunotherapeutic agent, such as an immune checkpoint inhibitor. The disclosure also provides compositions and/or methods for treating a subject with cancer. In some embodiments, the disclosure provides compositions and methods for combination therapy that comprises administering to a subject with cancer an effective amount of an agent that modulates RNA splicing and a therapeutically effective amount of an immunotherapeutic agent, such as an immune checkpoint inhibitor. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/998906 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Original (OR) Class A61K 45/06 (20130101) Peptides C07K 16/2818 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190725 | Djalilian |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali R. Djalilian (Chicago, Illinois) |
| ABSTRACT | The present disclosure relates to ophthalmic compositions and methods for inducing PAX6 expression in a cells and for reducing or preventing corneal scarring, corneal neovascularization and/or corneal opacification. The disclosure also provide for ophthalmic compositions and methods for improving vision or reducing limitations on vision. |
| FILED | Monday, April 27, 2020 |
| APPL NO | 17/511635 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 9/0053 (20130101) A61K 31/18 (20130101) A61K 31/166 (20130101) A61K 31/4523 (20130101) Original (OR) Class A61K 47/20 (20130101) A61K 47/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190752 | Shao et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jieya Shao (St. Louis, Missouri); Marc Diamond (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides methods to quantify VCP phosphorylation at specific amino acid residue to predict responsiveness of a subject having a cancer or tumor to a genotoxic treatment, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 18/045744 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 31/513 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/4375 (20130101) A61K 31/4439 (20130101) A61K 31/4745 (20130101) A61K 31/7048 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190758 | Gutmann et al. |
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| FUNDED BY |
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| APPLICANT(S) | David Gutmann (St. Louis, Missouri); Corina Anastasaki (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | David Gutmann (St. Louis, Missouri); Corina Anastasaki (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of methods for inhibiting neuronal activity in NF1 tumors. One aspect of the disclosure provides for a method of inhibiting tumor growth comprising administering a neuronal activity inhibiting agent to a subject in need thereof. Another aspect of the disclosure provides for a method of attenuating neuronal excitability, activity-regulated mitogen production, and tumor progression comprising administering a neuronal activity inhibiting agent to a subject in need thereof. Yet another aspect of the disclosure provides for a method of activating HCN channels in a subject comprising administering a neuronal activity inhibiting agent to a subject in need thereof. Yet another aspect of the disclosure provides for a method of treating brain or and nerve tumors in Neurofibromatosis type 1 (NF1) comprising administering a neuronal activity inhibiting agent to a subject in need thereof. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/069317 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) Original (OR) Class A61K 31/4192 (20130101) A61K 38/4886 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190767 | Eng et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Massachusetts General Hospital (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George Eng (Cambridge, Massachusetts); Omer Yilmaz (Cambridge, Massachusetts); Jonathan Braverman (Cambridge, Massachusetts) |
| ABSTRACT | Methods and compositions for enhancing Wnt signaling pathway activities in a tissue of a subject have been developed for the treatment of cancer, in particular cancers with one or more mutations in the APC (adenomatous polyposis coli) gene. Preferably, the amount of the compositions for enhancing Wnt signaling does not reduce or inhibit proliferation or viability of normal healthy cells in the subject. In some embodiments, pharmaceutical compositions including an effective amount of one or more GSK-3 inhibitors are administered to reduce cancer cell proliferation or viability in a subject. A preferred GSK-3 inhibitor is LY2090314 encapsulated within, or associated with nanoparticles. Dosage forms of LY2090314 encapsulated within, or associated with nanoparticles for administration are also described. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 18/045059 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/497 (20130101) A61K 31/5377 (20130101) A61K 31/5517 (20130101) Original (OR) Class A61K 38/1709 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 35/00 (20180101) Peptides C07K 14/475 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190770 | Covey et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); Sage Therapeutics, Inc. (Cambridge, Massachusetts) |
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| INVENTOR(S) | Douglas Covey (St. Louis, Missouri); Albert Jean Robichaud (Ringoes, New Jersey) |
| ABSTRACT | The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/107965 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/56 (20130101) A61K 31/58 (20130101) Original (OR) Class A61K 31/565 (20130101) A61K 31/566 (20130101) A61K 31/573 (20130101) Steroids C07J 1/0011 (20130101) C07J 1/0018 (20130101) C07J 1/0029 (20130101) C07J 5/0015 (20130101) C07J 7/002 (20130101) C07J 9/005 (20130101) C07J 13/007 (20130101) C07J 21/00 (20130101) C07J 21/006 (20130101) C07J 21/008 (20130101) C07J 41/0005 (20130101) C07J 41/0094 (20130101) C07J 51/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190773 | Burridge et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul W. Burridge (Chicago, Illinois); Tarek Magdy Shehata Mohamed (Chicago, Illinois) |
| ABSTRACT | Disclosed are methods, pharmaceutical compositions, kits, and systems for treating or preventing cardiotoxicity in a subject undergoing treatment with an anthracycline chemotherapeutic agent. The methods, pharmaceutical compositions, kits, and systems typically include or utilize a therapeutic agent that inhibits the activity or expression of the solute transporter SLC28A3. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051386 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/65 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190775 | VOLPE et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Matthew R. VOLPE (Cambridge, Massachusetts); Emily BALSKUS (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to methods and compositions for inhibition of ClbP and the treatment and/or prevention of cancer, e.g., colorectal cancer, a urinary tract cancer, a squamous cell carcinoma, an oral squamous cell carcinoma, or a head-and-neck cancer. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/108164 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190791 | Xu et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Peisheng Xu (Chapin, South Carolina); Haijun Liu (Columbia, South Carolina) |
| ABSTRACT | Described herein are methods and systems for the preparation of a brain targeted cerium oxide nanop article (CeNP) and its application in treating central neuronal system diseases. The brain targeted CeNP (T-CeNP) can effectively pass the blood brain barrier and specifically target brain tissue and exhibit anti-inflammatory and anti-oxidant effects. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/971694 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 33/244 (20190101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190797 | SCHEINBERG et al. |
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| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | David A. SCHEINBERG (New York, New York); Thomas J. GARDNER (New York, New York); Derek S. TAN (New York, New York); Jonghan LEE (New York, New York); Ivo LORENZ (New York, New York) |
| ABSTRACT | Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express an antigen-targeted chimeric antigen receptor and a prodrug converting enzyme for the treatment of inflammation, inflammatory diseases, or pathogenic infections. |
| FILED | Monday, July 02, 2018 |
| APPL NO | 16/627272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 31/04 (20180101) A61P 31/12 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/16 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/2803 (20130101) C07K 16/3038 (20130101) C07K 16/3053 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/86 (20130101) C12N 9/485 (20130101) Enzymes C12Y 304/17011 (20130101) C12Y 305/02006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190800 | Long et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Eric O. Long (Rockville, Maryland); Xiaoxuan Zhuang (Rockville, Maryland) |
| ABSTRACT | Chimeric antigen receptors including (a) an antigen binding domain; (b) a transmembrane domain; and (c) an intracellular domain comprising a first intracellular signaling domain from CD28 homolog (CD28H) and a second intracellular signaling domain are provided. In some examples, the second intracellular domain is from 2B4, TCRζ, FcεR1γ, or DAP12. Chimeric antigen receptors including (a) an antigen binding domain; (b) a transmembrane domain; and (c) an intracellular domain comprising a first intracellular signaling domain from CD28H, a second intracellular signaling domain from 2B4, and a third intracellular signaling domain are also provided. In some examples, the third intracellular domain is from TCRζ, FcεR1γ, or DAP12. Nucleic acid molecules encoding the CARs and expression vectors including the nucleic acids are also provided. Isolated cells (such as T cells or natural killer cells) expressing the CARs and methods of treating a subject with cancer with the isolated cells are provided. |
| FILED | Thursday, March 26, 2020 |
| APPL NO | 17/914027 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/70521 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190810 | Walter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Roland B. Walter (Seattle, Washington); George S. Laszlo (Seattle, Washington) |
| ABSTRACT | A suite of novel anti-CD33 antibodies is described. The provided antibodies are pan-binders, binding the C2-set Ig-like domain in the presence or absence of the V-set Ig-like domain of CD33; are C2-set specific binders, binding the C2-set Ig-like domain only in the absence of the V-set Ig-like domain of CD33; or are V-set binders, binding the V-set Ig-like domain of CD33. The antibodies provide novel therapeutic and diagnostic tools against CD33-related disorders, such as acute myeloid leukemia (AML). |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/995089 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 16/2803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190825 | Pamer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan-Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Eric Pamer (Guilford, Connecticut); Charlie Buffie (New York, New York); Peter McKenney (New York, New York) |
| ABSTRACT | The present invention relates to methods and compositions for reducing the risk and severity of C. difficile infection. It is based, at least in part, on the discovery that a restricted fraction of the gut microbiota, including the bacterium Clostridium scindens, contributes substantially to resistance against C. difficile infection. Without being bound by any particular theory, it is believed that this is achieved through the biosynthesis of secondary bile acids. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/047167 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class A61K 38/443 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/26 (20130101) Enzymes C12Y 101/01159 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190865 | Waller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edmund K. Waller (Atlanta, Georgia); Rebecca Pankove (Atlanta, Georgia); Susan Thomas (Atlanta, Georgia); Sruthi Ravindranathan (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to methods of treating cancer or viral infections comprising administering an effective amount of a VIP antagonist in combination with an immune check-point inhibitor to a subject in need thereof. In certain embodiments, the immune check-point inhibitor is an anti-PD1 or anti-PDL1 antibody. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/047135 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190870 | AAKALU |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinay Kumar AAKALU (Chicago, Illinois) |
| ABSTRACT | Methods are provided for using histatins in the treatment of Neimann Pick Type C Disease and other diseases associated with TMEM97 (sigma 2 receptor) or NPC1 activity and/or cholesterol or microtubule-associated protein 1 light chain 3 accumulation. Methods for modulating TMEM97 and/or NPC1 activity in the treatment of ocular diseases is also provided. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/925361 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190873 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The McLean Hospital Corporation (Belmont, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kwang-Soo Kim (Lexington, Massachusetts); Yongwoo Jang (Belmont, Massachusetts); Chun-Hyung Kim (Lexington, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions for treating a Nurr1-mediated and/or PPARγ-mediated condition. Also provided herein are methods and compositions for increasing Nurr1 or PPARγ activity and/or levels in a cell. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/869388 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/191 (20130101) A61K 31/4706 (20130101) A61K 38/177 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190883 | Desir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bessor Pharma, LLC (Framingham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary Desir (Framingham, Massachusetts); Arthur Felix (Framingham, Massachusetts); Wallace Dairman (Framingham, Massachusetts); Anthony Barrett (Rio de Janeiro, Brazil); Barry Berkowitz (Framingham, Massachusetts) |
| ABSTRACT | Disclosed are stable peptides that have renalase agonist activity and are useful for treating diseases such as AKI and AP, including those relating to SARS-CoV-2 |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/928381 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/44 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/18 (20180101) A61P 13/12 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0036 (20130101) Enzymes C12Y 106/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190886 | WAGNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Denisa D. WAGNER (Dover, Massachusetts); Siu Ling WONG (Brookline, Massachusetts); Kimberly Lindsay MARTINOD (Kortrijk, Belgium); Luise ERPENBECK (Göttingen, Germany); Jörn Thilo WITSCH (Freiburg, Germany); Alexander SAVCHENKO (Boston, Massachusetts) |
| ABSTRACT | Embodiments of the technology described herein are based, in part, upon the discovery that NETosis, the formation of neutrophil extracellular traps (NETs) is increased in wounds, in organ fibrosis and in subjects with diabetes. Accordingly, methods for treating wounds, fibrosis and NET associated complications in diabetes are provided. The methods comprise administrating a therapeutically effective amount of at least one anti-NET compound to a subject in need of treatment, e.g. a PAD 4 inhibitor, a DNase, a histone-degrading enzyme; an inhibitor of chromatin decondensation; an antibody against a component of a NET; an inhibitor of NET release, a protease inhibitor, or an elastase inhibitor. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/848998 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Original (OR) Class A61K 45/06 (20130101) Enzymes C12Y 301/21001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190887 | Kar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina); Ramot at Tel-Aviv University Ltd. (Tel Aviv, Israel); Tel HaShomer Medical Research Infrastructure and Services Ltd. (Ramat-Gan, Israel) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina); Ramot at Tel-Aviv University Ltd. (Tel Aviv, Israel); Tel HaShomer Medical Research Infrastructure and Services Ltd. (Ramat-Gan, Israel) |
| INVENTOR(S) | Amar N. Kar (Lexington, South Carolina); Pabitra Sahoo (West Columbia, South Carolina); Jeffery Twiss (Columbia, South Carolina); Sean McGill (Columbia, South Carolina); Eran Perlson (Tel Aviv, Israel); Topaz Altman (Tel Aviv, Israel); Ariel Razvan Ionescu (Tel Aviv, Israel); Tal Gradus-Pery (Tel Aviv, Israel); Amir Dori (Herzliya, Israel) |
| ABSTRACT | Testing peptides in in vitro models of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Frontotemporal dementia, Amyotrophic lateral sclerosis, to evaluate systems and methods of treatment therefore. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 17/989817 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190890 | Culp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BioVentures, LLC (Little Rock, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Culp (Little Rock, Arkansas); Robert Skinner (Little Rock, Arkansas); Evan C. Unger (Tucson, Arizona) |
| ABSTRACT | The present invention provides methods and combinations for reducing the infarct volume in a tissue of a subject undergoing ischemia or at risk of developing ischemia. |
| FILED | Saturday, December 10, 2022 |
| APPL NO | 18/078924 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/02 (20130101) A61K 33/00 (20130101) A61K 38/49 (20130101) A61K 38/482 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190893 | SUH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SUSIE SUH (Oakland, California); KRZYSZTOF PALCZEWSKI (Oakland, California); ELLIOT H. CHOI (Oakland, California) |
| ABSTRACT | A method of treating an inherited retinal disease (IRD) associated with a pathogenic point mutation in a mutant allele of an IRD-related gene in the retina or the retinal pigment epithelium (RPE) of a subject in need thereof includes base editing the pathogenic point mutation in the retinal cell or retinal pigment epithelium cell to correct the pathogenic mutation, generate a non-pathogenic point mutation, or modulate expression of an IRD-related gene and restore visual function of subject. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 18/016428 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/7105 (20130101) A61K 38/50 (20130101) Original (OR) Class A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190896 | Hacohen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nir Hacohen (Brookline, Massachusetts); Catherine Ju-Ying Wu (Brookline, Massachusetts); Edward F. Fritsch (Concord, Massachusetts) |
| ABSTRACT | The present invention relates to neoplasia vaccine or immunogenic composition administered in combination with other agents, such as checkpoint blockade inhibitors for the treatment or prevention of neoplasia in a subject. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877195 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/70 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) A61K 2039/545 (20130101) A61K 2039/55561 (20130101) Peptides C07K 16/2803 (20130101) C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190897 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dianqing Wu (New Haven, Connecticut); Lee Sun (New Haven, Connecticut) |
| ABSTRACT | The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor angiogenesis, and hence suppresses tumor formation. Thus, in various embodiments described herein, the methods of the invention relate to methods of treating cancer by administering to a patient an effective amount of DKK2 gene depleting agent, methods for providing anti-tumor immunity and anti-tumor angiogenesis in a subject, methods of stimulating a T cell mediated immune response to a cell population or a tissue and suppressing tumor angiogenesis in a subject. Additionally, the current invention includes methods of diagnosing a cancer or a predisposition of developing a cancer or a metastasis and methods for determining the use of immunotherapy treatment or cancer vaccine for treating cancer. Furthermore, the invention encompasses a pharmaceutical composition for treating cancer as well as a kit for carrying out the aforementioned methods. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/938549 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/395 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/18 (20130101) C07K 16/2818 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/57496 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190906 | SEVEAU |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie SEVEAU (Dublin, Ohio) |
| ABSTRACT | The present disclosure relates to listeriolysin O polypeptides and vaccine compositions for treating and preventing Listeria infection. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/765428 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/02 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/55544 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190908 | Bakaletz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Institute at Nationwide Children's Hospital (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lauren O. Bakaletz (Hilliard, Ohio); Steven D. Goodman (Hilliard, Ohio) |
| ABSTRACT | The disclosure provides methods and compositions that are useful to lessen and/or cure bacterial biofilms and treat diseases or disorders associated with biofilms using one or more novel polypeptide vaccines, antibodies, antibody fragments and compositions. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 18/047619 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/102 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/285 (20130101) C07K 16/1242 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190910 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiang Zhu (San Diego, California); Linling He (San Diego, California) |
| ABSTRACT | The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896799 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 38/162 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 39/21 (20130101) A61K 47/69 (20170801) A61K 47/646 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/005 (20130101) C07K 14/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190913 | Kawaoka et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoshihiro Kawaoka (Middleton, Wisconsin); Gabriele Neumann (Madison, Wisconsin); Huihui Kong (Madison, Wisconsin) |
| ABSTRACT | Methods of preparing influenza viruses having altered immunodominant epitopes in HA, e.g., having one or more residues in one or more of antigenic sites A-E in HA altered, and viral vectors, e.g., influenza virus VLPs or non-influenza viruses or VLPs thereof expressing or having influenza HAs with altered immunogenicity as a result of altered immunodominant epitopes therein are provided. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/813178 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/521 (20130101) Peptides C07K 16/34 (20130101) C07K 16/1018 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190914 | SCHIEF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL AIDS VACCINE INITIATIVE, INC. (New York, New York); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William SCHIEF (La Jolla, California); Manyuan MA (La Jolla, California); Jon STEICHEN (La Jolla, California); Xiaozhen HU (La Jolla, California); Sebastian RAEMISCH (La Jolla, California); Alessia LIGUORI (La Jolla, California); Torben SCHIFFNER (La Jolla, California); Jordan WILLIS (New York, New York); Christopher COTTRELL (La Jolla, California) |
| ABSTRACT | The invention relates to germline-targeting designs, stabilization designs, and/or combinations thereof, of proteins designed with modified surfaces helpful for immunization regimens, other protein modifications and/or development of nanoparticles, methods of making and using the same, and to (a) germline-targeting priming or boosting/shepherding immunogens to initiate or guide maturation of VRC01-class responses (b) PCT64/PG9-germline-targeting designs (c) BG18-germline-targeting designs or boosting/shepherding immunogens to initiate or guide maturation of BG18-like responses, and/or (d) trimer stabilization and presentation in a membrane-bound format. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/048960 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16022 (20130101) C12N 2740/16034 (20130101) C12N 2740/16071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190916 | SELVARAJ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | METACLIPSE THERAPEUTICS CORPORATION (Atlanta, Georgia); EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Periasamy SELVARAJ (Lilburn, Georgia); Christopher PACK (Atlanta, Georgia); Sampath RAMACHANDIRAN (Duluth, Georgia); J.C. Shaker REDDY (Roswell, Georgia); Luis Enrique MUNOZ (Atlanta, Georgia); Ramireddy BOMMIREDDY (Atlanta, Georgia) |
| ABSTRACT | Provided herein are recombinant polypeptides comprising a SARS-CoV-2 S1 protein binding domain polypeptide and a GM-CSF polypeptide, polynucleotide sequences encoding the same, virus-like particles comprising the same, and methods for using these compositions for the treatment of a SARS-CoV-2 infection in a subject, and for detection of a SARS-CoV-2 antibodies in a subject. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/925179 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 47/6901 (20170801) Peptides C07K 14/005 (20130101) C07K 14/535 (20130101) C07K 14/5434 (20130101) C07K 2319/035 (20130101) C07K 2319/75 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20023 (20130101) C12N 2770/20034 (20130101) C12N 2770/20071 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190919 | Hooper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Craig Hooper (Medford, New Jersey); Bernhardt Dietzschold (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided is a method of enhancing an antigen-induced long-lasting immune response in a host comprising administering to a host an effective amount of: (a) a nonpathogenic recombinant rabies virus comprising at least three copies of a mutated G gene, wherein said mutated G gene encodes a rabies virus glycoprotein wherein the glycoprotein amino acid 194 is serine and the glycoprotein amino acid 333 is glutamic acid, wherein said recombinant rabies virus does not express a foreign protein antigen; and (b) a Coronavirus antigen that is not expressed by the rabies virus. Also provided are related compositions, kits and vaccines. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/996119 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/205 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/20121 (20130101) C12N 2760/20122 (20130101) C12N 2760/20134 (20130101) C12N 2760/20162 (20130101) C12N 2760/20171 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) C12N 2770/20071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190920 | Irvine et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); La Jolla Institute for Immunology (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell Irvine (Arlington, Massachusetts); Shane Crotty (San Diego, California) |
| ABSTRACT | Immunization methods are provided. The methods typically include administering the subject an effective amount of an antigen and adjuvant to induce an immune response against an antigen, the method including two or more of (i) slow prime delivery of antigen and/or adjuvant, a (ii) temporally delayed 2nd immunization, and (iii) a robust adjuvant. Element (i) can be or include temporally extended exposure of antigen, adjuvant, or preferably the combination thereof, such as one or more of repeated administrations, infusion optionally by osmotic pump and escalating dosing. Element (ii) can include administering one or more boost doses of antigen and/or adjuvant, for example between 11 and 35 weeks after the start of the prime administration. A preferred robust adjuvant (iii) is one including non-liposome, non-micelle particles formed of a lipid, an additional adjuvant such as a TLR4 agonist, a sterol, and a saponin. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 18/047928 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190930 | FERNANDES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| INVENTOR(S) | Daniel FERNANDES (Awendaw, South Carolina); Laura Schwartz (Charleston, South Carolina); Natalie Sutkowski (Charleston, South Carolina); Brian Hoel (Charleston, South Carolina); Semyon Rubinchik (Buffalo Grove, Illinois) |
| ABSTRACT | The present disclosure provides anti-nucleolin antibodies, methods of producing anti-nucleolin antibodies, and cells producing anti-nucleolin antibodies. Also provided are methods of using anti-nucleolin antibodies in treating malignant and non-malignant diseases. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/839029 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/395 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/3015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190941 | MONTEZCO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lyndra Therapeutics, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan Jaramillo MONTEZCO (Watertown, Massachusetts); Marlene SCHWARZ (Auburndale, Massachusetts); Rosemary KANASTY (Cambridge, Massachusetts); David ALTREUTER (Wayland, Massachusetts); Nicholas DE LA TORRE (Boston, Massachusetts); Sonia HOLAR (Boston, Massachusetts); Tyler GRANT (Arlington, Massachusetts); Craig SIMSES (Quincy, Massachusetts); Erick PEEKE (Cambridge, Massachusetts); Erica LAI (Somerville, Massachusetts) |
| ABSTRACT | Gastric residence systems and methods of delivering a drug to an individual using a gastric residence system are described herein. The gastric residence system may include a time-dependent and/or enteric, or dual time-dependent and enteric polymeric linker. In some embodiments, the time-dependent polymeric linker includes PLGA, and optionally PLA or a carrier polymer. The enteric polymeric linker includes an enteric polymeric, and optionally a carrier polymer such as PCL or TPU. The time-dependent polymeric linker may degrade in the stomach of the individual according to a degradation (or flexural modulus loss) profile described herein, and the enteric polymeric linker may degrade in the intestine of the individual another degradation profile described herein (or flexural modulus loss). |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/774128 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/04 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 47/34 (20130101) A61K 47/593 (20170801) Original (OR) Class A61K 47/6937 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190948 | Law et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York); Tu Therapeutics Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shek Hang Benedict Law (New York, New York); Vanessa Bellat (New York, New York); Benjamin Byung-min Choi (Englewood Cliffs, New Jersey) |
| ABSTRACT | The present disclosure relates to a systemically administered peptide delivery platform that biodistributes to the kidney or urinary tract. The disclosure further relates to methods of treating a disease of the kidney or urinary tract in a subject in need thereof. |
| FILED | Wednesday, January 11, 2023 |
| APPL NO | 18/095753 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/65 (20170801) Original (OR) Class A61K 47/183 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/10 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190959 | Arboleda-Velasquez |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Joseph F. Arboleda-Velasquez (Newton, Massachusetts) |
| ABSTRACT | The present subject matter provides, inter alia compositions, formulations, and methods for inhibiting, treating, and preventing small vessel diseases. |
| FILED | Monday, March 26, 2018 |
| APPL NO | 16/499234 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Original (OR) Class A61K 48/0075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/907 (20130101) C12N 2800/107 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190961 | GOLDMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. GOLDMAN (Webster, New York); John N. Mariani (Rochester, New York) |
| ABSTRACT | The present disclosure is directed to methods of inducing rejuvenation in a population of adult glial progenitor cells, and methods of treating a subject having a myelin deficiency. The method of treating a subject having a myelin deficiency, may comprise expressing, in glial progenitor cells of the subject, one or more transcription factors selected from the group consisting of B-cell lymphoma/leukemia 11A (BCL11A), histone deacetylase 2 (HDAC2), histone-lysine N-methyltransferase EZH2 (EZH2), myc proto-oncogene protein (MYC), high mobility group protein HMGI-C (HMGA2), nuclear factor 1 B-type (NFIB), and transcriptional enhancer factor TEF-4 10 (TEAD2), wherein said expressing is effective to induce myelination in the subject, thereby treating the myelin deficiency. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 18/047744 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) A61K 38/50 (20130101) A61K 38/1709 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0066 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/80 (20130101) C12N 9/1007 (20130101) C12N 15/86 (20130101) C12N 2740/15032 (20130101) C12N 2740/15043 (20130101) Enzymes C12Y 305/01098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190963 | Ganesh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Karuna Ganesh (New York, New York); Manuel Valiente (Madrid, Spain); Joan Massague (New York, New York) |
| ABSTRACT | The present invention relates to methods and compositions for inhibiting metastatic spread of cancer and/or inhibiting progression of pre-existing metastatic disease in a subject using L1CAM inhibition. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 18/045357 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/519 (20130101) A61K 45/06 (20130101) A61K 48/0016 (20130101) A61K 48/0066 (20130101) Original (OR) Class A61K 48/0083 (20130101) A61K 48/0091 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191109 | Badran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bashar Badran (San Ramon, California); Mark George (Sullivans Island, South Carolina); Doe Jenkins (Johns Island, South Carolina); Daniel Cook (Charleston, South Carolina) |
| ABSTRACT | The present invention relates to systems for providing noninvasive cranial nerve stimulation and methods for using the same. The present invention administers therapy through electrodes that are noninvasively attached to one or more of a subject’s cranial nerve. The systems can be used to enhancing rehabilitation and recovery by improving neuroplasticity and coupling muscle training with feedback. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/059503 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0452 (20130101) Original (OR) Class A61N 1/0456 (20130101) A61N 1/36031 (20170801) A61N 1/36034 (20170801) A61N 1/36036 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191114 | MURATORI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OLD DOMINION UNIVERSITY RESEARCH FOUNDATION (Norfolk, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Claudia MURATORI (Norfolk, Virginia); Erin B. PURCELL (Norfolk, Virginia); Asia POUDEL (Norfolk, Virginia); Adenrele M. OLUDIRAN (Norfolk, Virginia) |
| ABSTRACT | Methods and apparatuses are described herein for inactivation of bacterial biofilms using sub-microsecond pulsed electric field application to an affected surface or region. In some examples, a bacterial biofilm may be inactivated while planktonic bacteria in the vicinity of the biofilm are not inactivated. These methods and systems provide an electrical-based therapeutic modality for which bacteria in biofilms may have difficulty developing resistance, unlike antibiotic therapies. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/996104 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 2018/00732 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/328 (20130101) A61N 1/0476 (20130101) Original (OR) Class A61N 1/36034 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191130 | Bartlett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Edward Lee Bartlett (West Lafayette, Indiana); Brandon Steven Coventry (Verona, Wisconsin) |
| ABSTRACT | The neuromodulation system includes a sensor, a recording amplifier, a processor, and a stimulator. The neuromodulation system is configured to provide stimulation and control of an intended target. The processor utilizes a closed-loop feedback system which is configured to actively sense target brain states and apply corrective stimulation or feedback as dictated by its effectors. The processor implements reinforcement learning which creates real-time statistical models of current and recent past neural states which actively and automatically learns stimulation paradigms which create paths from pathological to nominal brain states. |
| FILED | Saturday, December 17, 2022 |
| APPL NO | 18/083490 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36139 (20130101) Original (OR) Class A61N 1/36146 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192594 | Thomas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as Represented by the Secretary, Department of Health (Bethesda, Maryland); University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig Thomas (Gaithersburg, Maryland); Carlos Zarate (Germantown, Maryland); Ruin Moaddel (Bel Air, Maryland); Todd Gould (Elkridge, Maryland); Panos Zanos (Baltimore, Maryland); Patrick Morris (Columbia, Maryland) |
| ABSTRACT | The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketam-ine (HNK) includes preparation of (R)-norket-amine via chiral resolution from racemic norketamine via a chiral resolution with L-pyro-glutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hy-droxynorketamine hydrochloride salts. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/170048 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic or Carbocyclic Compounds C07C 221/00 (20130101) C07C 225/20 (20130101) Original (OR) Class C07C 269/06 (20130101) C07C 2601/14 (20170501) C07C 2601/16 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192598 | Bergeson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan Bergeson (Lubbock, Texas); Peter Syapin (Camarillo, California); Ted W. Reid (Wolfforth, Texas); Mayank Shashtri (Lubbock, Texas); Phat L. Tran (Lubbock, Texas) |
| ABSTRACT | The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising a modified tetracycline molecule, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, and tautomers thereof comprise: a Deamino Diacetyl Minocycline, hyl Ether Minocycline, Ethyl Ether Minocycline, Propyl Ether Minocycline, Butyl Ether Minocycline, Butyl Ether Monoacetyl Minocycline, Butyl Ether Diacetyl Minocycline, Buty Ether Triacetyl Minocycline, or Butyl Ether Tetra Acetyl Minocycline. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/908999 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/32 (20180101) Acyclic or Carbocyclic Compounds C07C 237/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192601 | Thompson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | David Harley Thompson (West Lafayette, Indiana); Zoltan Kalman Nagy (West Lafayette, Indiana); Ahmed Mufti (Lafayette, Indiana); Jaron Mackey (Austin, Texas) |
| ABSTRACT | The present disclosure provides processes and apparatuses for the scaled-up manufacture of lomustine via continuous flow manufacture. Such continuous flow processes may optionally include the crystallization of lomustine and the apparatuses may optionally include crystallization apparatuses/reactors in either batch or continuous flow design. In one aspect of the disclosure, a process for making lomustine is provided comprising treating solutions of 2-chloroethylisocyanate with a solution of cyclohexylamine with continuous-flow pumps in a gram-flow reactor to form a combined solution, adding deionized water with a continuous flow-pump to the combined solution to form a liquid-organic phase solution, extracting the organic phase from the solution and treating with a solution of t-butyl nitrite with a continuous flow pump in a gram flow reactor to form lomustine. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/924865 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 273/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192606 | Matzuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Martin Matzuk (Houston, Texas); Surendra Dawadi (Houston, Texas); Melek Ucisik (Houston, Texas); John Faver (Houston, Texas); Kurt Bohren (Houston, Texas); Feng Li (Houston, Texas) |
| ABSTRACT | Novel direct thrombin inhibitors are provided herein, along with methods for their use as anticoagulants. The direct thrombin inhibitors described herein are useful in treating and/or preventing thromboembolism and bleeding or clotting disorders. Also provided herein are methods for inhibiting thrombin in a cell using the compounds and compositions described herein. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/996097 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 279/14 (20130101) Heterocyclic Compounds C07D 207/08 (20130101) Original (OR) Class C07D 311/68 (20130101) C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192610 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremiah A. Johnson (Boston, Massachusetts); Hung Vanthanh Nguyen (Braintree, Massachusetts); Peyton Shieh (Cambridge, Massachusetts); Wencong Wang (Cambridge, Massachusetts); Bin Liu (Hopkinton, Massachusetts); Valerie Lensch (Cambridge, Massachusetts); Landon Kilgallon (Cambridge, Massachusetts); Yutong Dai (Somerville, Massachusetts); Samantha Lynn Kristufek (Lubbock, Texas) |
| ABSTRACT | The present disclosure provides enynes, end-functionalized polymers, conjugates, methods of preparation, compositions, kits, and methods of use. The conjugates comprise at least (1) a peptide (e.g., an antibody), protein, nucleoprotein, mucoprotein, lipoprotein, glycoprotein, or polynucleotide; and (2) a polymer comprising a pharmaceutical agent. The conjugates may be useful in delivering (e.g., targeted delivering) the pharmaceutical agent to a subject in need thereof or cell or treating, preventing, or diagnosing a disease. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 17/970533 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 233/60 (20130101) C07C 301/02 (20130101) Heterocyclic Compounds C07D 207/277 (20130101) Original (OR) Class C07D 257/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192626 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Jin Wang (Houston, Texas); Hui Zheng (Houston, Texas); Lisheng Deng (Houston, Texas); Anamitra Ghosh (Houston, Texas) |
| ABSTRACT | Novel soluble epoxide hydrolase (sEH) inhibitors are provided, along with methods for their use. The soluble epoxide hydrolase inhibitors are useful in treating and/or preventing sEH-related related diseases, such as Alzheimer's disease and inflammation. Also provided are methods for inhibiting soluble epoxide hydrolase in a cell using the compounds and compositions described herein. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/999408 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 235/14 (20130101) C07D 235/18 (20130101) Original (OR) Class C07D 235/20 (20130101) C07D 235/26 (20130101) C07D 235/30 (20130101) C07D 401/04 (20130101) C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 403/04 (20130101) C07D 403/10 (20130101) C07D 403/12 (20130101) C07D 405/04 (20130101) C07D 413/10 (20130101) C07D 413/12 (20130101) C07D 417/04 (20130101) C07D 471/04 (20130101) C07D 473/34 (20130101) C07D 473/40 (20130101) C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192644 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Stanford, California); Eric S. Fischer (Chestnut Hill, Massachusetts); Alyssa Verano (Allston, Massachusetts); Hu Liu (Newton, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Lyn H. Jones (Winchester, Massachusetts); Eric S. Wang (Brookline, Massachusetts); Radoslaw Nowak (Boston, Massachusetts); Jianwei Che (Sharon, Massachusetts) |
| ABSTRACT | Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, and tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/926074 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/04 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 405/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192671 | Ghosh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Hiroaki Mitsuya (Kumamoto, Japan); Andrew Mesecar (West Lafayette, Indiana) |
| ABSTRACT | Bis-amide inhibitors of SARS-CoV-2 (COVID); pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/998909 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/56 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 405/12 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 409/14 (20130101) C07D 413/12 (20130101) C07D 493/04 (20130101) C07D 493/06 (20130101) C07D 493/08 (20130101) C07D 498/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192718 | Sandanayaka |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NIROGY THERAPEUTICS, INC. (Natick, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent Sandanayaka (Northborough, Massachusetts) |
| ABSTRACT | The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172742 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 495/04 (20130101) Original (OR) Class C07D 513/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192728 | Holtzman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Michael J. Holtzman (St. Louis, Missouri); Arthur G. Romero (Chesterfield, Missouri); Benjamin J. Gerovac (St. Louis, Missouri); Zhenfu Han (St. Louis, Missouri); Shamus P. Keeler (University City, Missouri); Kangyun Wu (St. Louis, Missouri) |
| ABSTRACT | Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863657 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/75 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0812 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230192733 — SUBSTITUTED PHENYL ET458HYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS
| US 20230192733 | Ahmed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Southern Research Institute (Birmingham, Alabama); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Syed Kaleem Ahmed (Hoover, Alabama); Shilpa Dutta (Birmingham, Alabama); John Phillip Tillotson (Birmingham, Alabama); Corinne E. Augelli-Szafran (Homewood, Alabama); Ashish Kumar Pathak (Hoover, Alabama); Omar Moukha-Chafiq (Hoover, Alabama); Timothy Patrick Sheahan (Chapel Hill, North Carolina); Ralph S. Baric (Haw River, North Carolina); Amy Catherine Sims (Richland, Washington); Mark R. Denison (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/086445 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/56 (20130101) C07D 401/12 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/58 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192759 | Pettit et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George R. Pettit (Paradise Valley, Arizona); Noeleen Melody (Mesa, Arizona) |
| ABSTRACT | The present disclosure relates to Betulastatin compounds, pharmaceutical compositions and kits comprising such compounds, and methods for using such compounds or pharmaceutical compositions. |
| FILED | Wednesday, February 08, 2023 |
| APPL NO | 18/166008 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Steroids C07J 63/008 (20130101) Original (OR) Class C07J 71/0052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192766 | Mozhdehi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Davoud Mozhdehi (Syracuse, New York); Md Shahadat Hossain (Syracuse, New York) |
| ASSIGNEE(S) | SYRACUSE UNIVERSITY (SYRACUSE, New York) |
| INVENTOR(S) | Davoud Mozhdehi (Syracuse, New York); Md Shahadat Hossain (Syracuse, New York) |
| ABSTRACT | A programmable assembly of proteins into well-defined nanoworms with broadened stability regimes is disclosed. Posttranslational modifications (PTMs) were used to generate lipidated proteins with precise topological and compositional asymmetry. Using an integrated experimental and computational approach, the material properties (thermoresponse and nanoscale assembly) of these hybrid amphiphiles are modulated by their amphiphilic architecture. The judicious choice of amphiphilic architecture can be used to program the assembly of proteins into adaptive nanoworms that undergo a morphological transition (sphere-to-nanoworms) in response to temperature stimuli. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 18/053517 |
| CURRENT CPC | Peptides C07K 7/06 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192775 | Kawaoka et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoshihiro Kawaoka (Middleton, Wisconsin); Gabriele Neumann (Madison, Wisconsin); Jihui Ping (Nanjing, China PRC) |
| ABSTRACT | An isolated recombinant influenza virus is provided having PA, PB1, PB2, NP, NS, M, NA and HA viral segments, wherein the PB1 viral segment encodes a PB1 with a residue other than isoleucine at position 711 or the M viral segment encodes a M1 with a residue other than methionine at position 128, wherein the recombinant influenza virus has enhanced replication relative to a corresponding influenza virus having a PB1 viral segment that encodes a PB1 with an isoleucine at position 711 or having a M viral segment that encodes a M1 with methionine at position 128, as well as methods of making and using the virus. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/813200 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 9/0019 (20130101) A61K 39/145 (20130101) A61K 2039/54 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192794 | GARCIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenan Christopher GARCIA (Palo Alto, California); Robert Andrew SAXTON (Palo Alto, California); Lukas Teoman HENNEBERG (Planegg, Germany) |
| ABSTRACT | The present disclosure relates generally to compositions and methods for modulating signal transduction mediated by interleukin-22 (IL-22). In particular, the disclosure provides novel IL-22 polypeptide variants with altered binding affinity to interleukin-10 receptor subunit beta (IL-10Rβ). Also provided are compositions and methods useful for producing such IL-22 polypeptide variants, as well as methods for modulating IL-22-mediated signaling, and/or for the treatment of conditions associated with the perturbation of signal transduction mediated by IL-22. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/995985 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/20 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/18 (20180101) A61P 37/06 (20180101) Peptides C07K 14/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192796 | GARCIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenan Christopher GARCIA (Palo Alto, California); Robert Andrew SAXTON (Palo Alto, California) |
| ABSTRACT | The present disclosure relates generally to compositions and methods for modulating signal transduction mediated by interleukin-10 (IL-10). In particular, the disclosure provides novel IL-10 polypeptide variants with altered binding affinity to interleukin-10 receptor subunit beta (IL-10Rβ). Also provided are compositions and methods useful for producing such IL-10 polypeptide variants, as well as methods for modulating IL-10-mediated signaling, and/or for the treatment of conditions associated with the perturbation of signal transduction mediated by IL-10. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/999528 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/5428 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192820 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang WANG (Wellesley, Massachusetts); Mark S.J. KLEMPNER (Boston, Massachusetts); Qi LI (Westwood, Massachusetts); Monir EJEMEL (Medfield, Massachusetts) |
| ABSTRACT | The invention provides anti-SARS-CoV-2 spike (S) protein antibodies and methods of using the same. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/923546 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192823 | Diskin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California); The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ron Diskin (Rehovot, Israel); Pamela J. Bjorkman (Altadena, California); Michel Nussenzweig (New York, New York); Johannes Scheid (New York, New York) |
| ABSTRACT | Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4, these antibodies having improved potency and breadth. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046481 |
| CURRENT CPC | Peptides C07K 16/1063 (20130101) Original (OR) Class C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192846 | KIPPS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas J. KIPPS (San Diego, California); George F. WIDHOPF (San Diego, California) |
| ABSTRACT | Provided herein are, inter alia, antibodies (e.g., humanized antibodies, monoclonal antibodies), antibody fragments (e.g., scFvs) and antibody compositions (e.g., chimeric antigen receptors, bispecific antibodies), which bind human tyrosine kinase-like orphan receptor 2 (ROR2) with high efficiency and specificity. The antibodies and antibody compositions provided herein include novel light and heavy chain domain CDRs and framework regions and are, inter alia, useful for diagnosing and treating cancer and other ROR2-related diseases. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/777591 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/6849 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192863 | Abiff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (CLEVELAND, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Muta Abiff (Cleveland, Ohio); Alex Yee-Chen Huang (Cleveland, Ohio) |
| ABSTRACT | A method of sensitizing cancer to immunotherapy in a subject in need thereof includes administering to the subject a therapeutically effective amount of a CdK5 inhibitor to suppress immune checkpoint PD-L1. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/167438 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/39541 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/70596 (20130101) C07K 16/2827 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Enzymes C12Y 207/11022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192904 | Choudhary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Choudhary (Boston, Massachusetts); Vika Anokhina (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to chimeric small molecules, which find utility as modifiers of target substrates according to the formula A-L1-E-B or A-L1-E-L2-B, wherein A is a kinase binding moiety; B is a target binding moiety; L1 and L2 are each a linker; and E is an electrophilic reactive group. Molecules according to the present invention find use making substrate modifications such as post-translational modifications to targets that are not the natural substrate of the kinase; accordingly, diseases or disorders may be treated or prevented with molecules of the present disclosure. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 18/057127 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0017 (20130101) Peptides C07K 16/40 (20130101) C07K 19/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193200 | VO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (BOSTON, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMDRIDGE, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (BOSTON, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMDRIGE, Massachusetts) |
| INVENTOR(S) | Linda Thuy VO (Pacifica, California); George Q. DALEY (Weston, Massachusetts) |
| ABSTRACT | Embodiments disclosed here are production methods and compositions of engineered immune cells, such as B or T lymphocytes, from limited lineage myeloid progenitor cells, or from pluripotent stem cells, or from multilineage hematopoietic progenitor cells comprising the addition of various cell differentiation transcription factors and inhibiting epigenetic histone methylations in said cells. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 18/050290 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) C12N 5/0636 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2501/42 (20130101) C12N 2501/60 (20130101) C12N 2501/065 (20130101) C12N 2501/65 (20130101) C12N 2501/602 (20130101) C12N 2501/603 (20130101) C12N 2501/604 (20130101) C12N 2501/606 (20130101) C12N 2501/608 (20130101) C12N 2506/11 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193221 | Bowie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James U. Bowie (Los Angeles, California); Meaghan Valliere (Leominster, Massachusetts); Tyler P. Korman (Sierra Madre, California); Nicholas Woodall (Knoxville, Tennessee) |
| ABSTRACT | Provided is an enzyme useful for prenylation and recombinant pathways for the production of cannabinoids, cannabinoid precursors and other prenylated chemicals in a cell free system as well and recombinant microorganisms that catalyze the reactions. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/049221 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/22 (20130101) C12P 7/42 (20130101) C12P 9/00 (20130101) C12P 17/06 (20130101) Enzymes C12Y 205/01039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193235 | Procko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Erik Procko (Champaign, Illinois); Asrar Malik (Chicago, Illinois); Jalees Rehman (Chicago, Illinois); Lianghui Zhang (Chicago, Illinois); Shiqin Xiong (Chicago, Illinois) |
| ABSTRACT | The modified polypeptides include at least one amino acid substitution that allows the polypeptide to bind better to the S surface glycoprotein of coronaviruses that use ACE2 as a cell entry receptor, either through direct increases in affinity or through improved folding and expression of ACE2. Use of the modified ACE2 polypeptides for inhibiting CoV entry, replication and/or spread, for pre-exposure and post-exposure CoV prophylaxis, and for treating a CoV infection (e.g. COVTD-19), is also described. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/911813 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6421 (20130101) Original (OR) Class C12N 15/62 (20130101) Enzymes C12Y 304/17023 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193242 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Bernd Zetsche (Cambridge, Massachusetts); Jonathan Strecker (Cambridge, Massachusetts) |
| ABSTRACT | Embodiments herein include engineered CRISPR-Cas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein (e.g., C2c1) that enhances binding of the of the CRISPR complex to the binding site and/ or alters editing preference as compared to wild type. Embodiments disclosed further include viral vectors for delivery of CRISPR-Cas effector proteins. The vectors may be designed to allow packaging of the CRISPR-Cas effector protein within a single vector. Certain embodiments further include delivery vectors, constructs, and methods of delivering larger genes for systemic delivery. |
| FILED | Friday, December 21, 2018 |
| APPL NO | 16/772222 |
| CURRENT CPC | Peptides C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193249 | Dekker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Job Dekker (Princeton, Massachusetts); Josee Dostie (Montreal, Canada) |
| ABSTRACT | The present invention relates to genomic analysis. In particular, the present invention provides methods and compositions for mapping genomic interactions. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890661 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1072 (20130101) Original (OR) Class C12N 15/1093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193250 | Lim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel A. Lim (San Francisco, California); Martina Malatesta (San Francisco, California); Siyuan John Liu (San Francisco, California) |
| ABSTRACT | The present disclosure relates generally to detection of long noncoding RNA (lncRNA) molecules in a sample or diagnosis of subject based upon detection of long noncoding RNAs in a sample, specifically to identify and use of molecular biomarkers or cancer including malignant glioma. Also provided are compositions and methods for treating malignant glioma in a subject, as well as human brain organoid models of malignant glioma and methods of generating and using the same. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/911633 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) C12N 15/1079 (20130101) Original (OR) Class C12N 15/1082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193255 | Doudna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Jennifer Rose Hamilton (Berkeley, California) |
| ABSTRACT | The present disclosure provides a virus-like particle (VLP) comprising a therapeutic polypeptide, and nucleic acids comprising nucleotide sequences encoding the components of the VLP. The present disclosure provides a virus-like particle (VLP) comprising a CRISPR/Cas effector polypeptide, and nucleic acids comprising nucleotide sequences encoding the components of the VLP. The present disclosure provides a system for making a VLP of the present disclosure, as well as methods of making the VLP. |
| FILED | Friday, November 15, 2019 |
| APPL NO | 17/287392 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/1138 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193257 | Khalili |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Temple University - of the Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kamel Khalili (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | Compositions and methods are provided for Tat-inducible expression of a CRISPR-associated endonuclease by a truncated HIV LTR promoter containing at least a core region and a TAR region of a HIV LTR promoter. The compositions may be used as a therapeutic treatment for the treatment and/or prevention of HIV. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/866261 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 48/005 (20130101) A61K 48/0075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/1132 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) C12N 2320/30 (20130101) C12N 2740/16062 (20130101) C12N 2800/22 (20130101) C12N 2800/107 (20130101) C12N 2830/00 (20130101) C12N 2830/30 (20130101) C12N 2830/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193258 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hua Yu (Glendora, California); Marcin Kortylewski (Monrovia, California); Richard Jove (Pasadena, California); Piotr Marek Swiderski (San Dimas, California); John J. Rossi (Azusa, California) |
| ABSTRACT | The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. More particularly, the present invention relates to multifunctional molecules that are capable of being delivered to cells of interest for the treatment of diseases and for the improvement in immune function. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/535191 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 47/55 (20170801) A61K 47/61 (20170801) A61K 47/64 (20170801) A61K 47/549 (20170801) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 15/1135 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193281 | Khvorova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastasia Khvorova (Westborough, Massachusetts); James W. Gilbert (Worcester, Massachusetts); Chantal Ferguson (Worcester, Massachusetts); Robert Brown (Needham, Massachusetts); Alexandra Weiss (Bolton, Massachusetts) |
| ABSTRACT | This disclosure relates to novel SOD1 targeting sequences. Novel SOD1 targeting oligonucleotides for the treatment of SOD1-related familial amyotrophic lateral sclerosis (ALS). |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/982993 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193295 | Maianti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Juan Pablo Maianti (Cambridge, Massachusetts); David R. Liu (Cambridge, Massachusetts); Luke W. Koblan (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are systems, compositions, and methods for the incorporation of unnatural amino acids into proteins via nonsense suppression or rare codon suppression. Nonsense codons and rare codons may be introduced into the coding sequence of a protein of interest using a CRISPR/Cas9-based nucleobase editor described herein. The nucleobase editors are able to be programmed by guide nucleotide sequences to edit the target codons in the coding sequence of the protein of interest. Also provided are application enabled by the technology described herein. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 18/055274 |
| CURRENT CPC | Peptides C07K 2319/81 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 15/67 (20130101) Original (OR) Class C12N 15/102 (20130101) Enzymes C12Y 305/04001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193315 | NAKAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health & Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroyuki NAKAI (West Linn, Oregon); Samuel HUANG (Portland, Oregon); Kei ADACHI (Beaverton, Oregon) |
| ABSTRACT | Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods. This disclosure also provides novel AAV capsid mutants. TRADE technology was used to identify novel AAV vectors that mediate neuronal transduction in the brain following intravenous administration. Application of TRADE in vivo resulted in the identification of new AAV capsids that can transduce neurons more efficiently and more specifically than AAV9 in the brain following administration of the new AAV capsids. The disclosed methods may be used to identify AAV capsids that target various cell populations. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/427513 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/1082 (20130101) C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) C12N 2750/14145 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193317 | Gao et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaojing Gao (Pasadena, California); Lucy S. Chong (Pasadena, California); Michael B. Elowitz (Pasadena, California); Matthew S-M Kim (San Francisco, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and systems suitable for use in delivering a polynucleotide to a target cell of a subject in need thereof. In some embodiments, a viral vector comprises a polynucleotide encoding nucleoprotein (N), phosphoprotein (P), matrix protein (M), RNA-dependent RNA polymerase (L), and one or more transgenes. The viral vector can comprise one or more of a conditionally stable fusion protein, a protease fusion protein, a degron fusion protein, and/or a glycoprotein derived of another species than the viral vector polynucleotide to enable control of viral vector transduction and/or replication. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/935024 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 16/18 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2319/30 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/506 (20130101) C12N 15/62 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2740/11045 (20130101) C12N 2760/20143 (20130101) C12N 2810/6054 (20130101) C12N 2820/002 (20130101) C12N 2820/007 (20130101) Enzymes C12Y 304/21098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193320 | KORNETE et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITÄT BASEL (Basel, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mara KORNETE (Basel, Switzerland); Lukas JEKER (Riehen, Switzerland) |
| ABSTRACT | The invention relates to a method to determine a homology directed repair (HDR) event within a eukaryotic cell, wherein the cell expresses a first isoform of a surface protein, which is different from a second isoform of said surface protein with regard to an amino acid marker. The method comprises the steps of inducing a DNA double strand break, providing a HDR template DNA construct comprising the amino acid marker corresponding to the second isoform of the surface protein and subsequently determining the expression of the first or second isoform of said surface protein on said cell, wherein expression of the second isoform indicates a successful HDR event. The invention also relates to a method for editing a genomic location of interest within a eukaryotic cell, and to a method of selectively depleting or enriching an edited cell in a composition of non-edited and edited cells. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/948313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/28 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0647 (20130101) C12N 15/102 (20130101) C12N 15/902 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193322 | Standage-Beier et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kylie Standage-Beier (Phoenix, Arizona); Parithi Balachandran (Coimbatore, India); Nicholas Brookhouser (Tempe, Arizona); David Brafman (Phoenix, Arizona); Xiao Wang (Chandler, Arizona) |
| ABSTRACT | Disclosed are recombinant Cas9 proteins, methods of production, and methods of use for targeted DNA deletions, DNA insertions, or both in a eukaryotic genome. An assay system for evaluating the ability of the recombinant Cas9 proteins for targeted DNA deletions, DNA insertions, or both in a eukaryotic genome is also disclosed. |
| FILED | Tuesday, April 14, 2020 |
| APPL NO | 17/602581 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) Enzymes C12Y 301/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193323 | CHATTERJEE et al. |
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| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saswati CHATTERJEE (Duarte, California); Laura Jane SMITH (Duarte, California); Kamehameha WONG (Duarte, California) |
| ABSTRACT | Adeno-associated virus (AAV) Clade F vectors or AAV vector variants (relative to AAV9) for precise editing of the genome of a cell and methods and kits thereof are provided. Targeted genome editing using the AAV Clade F vectors or AAV vector variants provided herein occurred at frequencies that were shown to be 1,000 to 100,000 fold more efficient than has previously been reported. Also provided are methods of treating a disease or disorder in a subject by editing the genome of a cell of the subject via transducing the cell with an AAV Clade F vector or AAV vector variant as described herein and further transplanting the transduced cell into the subject to treat the disease or disorder of the subject. Also provided herein are methods of treating a disease or disorder in a subject by in vivo genome editing by directly administering the AAV Clade F vector or AAV vector variant as described herein to the subject. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/815065 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0008 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2710/16622 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) C12N 2750/14152 (20130101) C12N 2750/14171 (20130101) C12N 2800/70 (20130101) C12N 2840/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193328 | Miller et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Garret P. Miller (Waltham, Massachusetts); Wajid Waheed Bhat (Haslett, Michigan); Emily R. Lanier (Haslett, Michigan); Sean Johnson (Bedford, Massachusetts); Davis T. Mathieu (East Lansing, Michigan); Björn Hamberger (Okemos, Michigan) |
| ABSTRACT | The disclosure relates to a method of making at least one serrulatane comprising contacting a terpene or a terpenoid substrate with at least one of a cis-prenyl transferase, a terpene synthase, and a cytochrome P45Q. The disclosure also relates to an expression system comprising one or more expression cassettes, each expression cassette comprising a promoter operably linked to a nucleic acid segment encoding at least one of: a cis-prenyl transferase, a terpene synthase, and a cytochrome P450. The disclosure also relates to a host cell comprising an expression system comprising one or more expression cassettes, each expression cassette comprising a promoter operably linked to a nucleic acid segment encoding at least one of: a cis-prenyl transferase, a terpene synthase, and a cytochrome P450. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/905749 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/22 (20130101) Original (OR) Class Enzymes C12Y 114/14 (20130101) C12Y 205/01087 (20130101) C12Y 402/03112 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193353 | Fleischmann et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zoe Fleischmann (Flourtown, Pennsylvania); Konstantin Khrapko (Newton, Massachusetts); Dori C. Woods (Londonderry, New Hampshire); Jonathan L. Tilly (Windham, New Hampshire) |
| ABSTRACT | Disclosed are compositions and methods related to the use of plurality of reverse transcriptase primers, unique molecular identifiers (UMIs), and/or spiky primers with unique junction identifiers to improve the sequencing and amplifications methods. In some embodiments, the disclosed methods can identify sequencing errors and PCR-jumping errors. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/923700 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193356 | Al'Khafaji et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Aziz Al'Khafaji (Cambridge, Massachusetts); Paul Blainey (Cambridge, Massachusetts); Nir Hacohen (Boston, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods for single-cell nucleic acid sequencing, and specifically provides for pre-amplifying target nucleic acids in a manner that allows for more proportionate detection of all target nucleic acids, including low prevalence/abundance RNAs, from individual cells. The disclosure also provides for application of a series of barcoding steps to associate cell-specific identifiers (IDs) to the targeted nucleotide sequences, and ultimately provides for increased throughput capacity and greater accuracy of single-cell nucleic acid sequencing. Certain aspects of the present disclosure also provide for improved quantitative detection of nucleic acid sequence barcodes, which in embodiments allows for highly sensitive quantitative detection of barcoded antibody levels and/or highly sensitive quantitative detection of barcoded antibody-bound protein levels (e.g., where specific antibodies are labeled with a barcoded oligonucleotide that is specific to each barcoded antibody's target. In such approaches, the oligonucleotide barcode can serve as a target nucleic acid sequence for the capture probes of the instant disclosure. Compositions, methods and kits related to specific combinations of capture probes are also provided. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 18/000222 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193362 | Pierce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Molecular Instruments, Inc. (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Niles A. Pierce (Pasadena, California); Harry Ming Tak Choi (Los Angeles, California) |
| ABSTRACT | Methods of analysis of a sample using hybridization chain reaction (HCR) are provided herein. Some embodiments involve one, two, or all three of the following aspects: 1) repeated signal detection, 2) overlapping binding sites, and 3) catalytic reporter deposition (CARD). Compositions and kits relating to these are also provided. Some embodiments encompass a method for repeated signal detection with reporter-labeled HCR hairpins involving providing a sample possibly containing one or more targets as well as possibly other molecules that are not targets, providing one or more probe sets each comprising either: a) one or more HCR initiator-labeled probes, or b) one or more probe units each comprising two or more HCR fractional initiator probes, providing one or more HCR amplifiers (each labeled with one or more reporters), detecting one or more signals from one or more reporters. In some embodiments, a probe unit comprises two or more HCR fractional initiator probes, wherein an HCR fractional initiator probe comprises a target-binding region and a fractional initiator, wherein the target-binding regions within a probe unit are configured to bind to overlapping or non-overlapping binding sites on the target, and wherein the fractional initiators on the probes within each probe unit are configured to bind to overlapping or non-overlapping binding sites on an HCR hairpin. Some embodiments encompass a method for HCR-mediated catalytic reporter deposition (CARD) for signal detection with hapten-labeled HCR hairpins involving providing a sample possibly containing one or more targets as well as possibly other molecules that are not targets, providing one or more probe sets each comprising either: a) one or more HCR initiator-labeled probes, or b) one or more probe units each comprising two or more HCR fractional initiator probes, providing one or more HCR amplifiers (each labeled with one or more haptens), providing one or more anti-haptens labeled with one or more reporter entities, wherein the reporter entity is an enzyme that mediates CARD, providing one or more CARD-substrates leading to deposition of one or more reporters, and detecting one or more signals from one or more reporters. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682336 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) Original (OR) Class C12Q 1/6825 (20130101) C12Q 1/6841 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193363 | Fraser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Scott E. Fraser (Glendale, Arizona); Simon Restrepo (Culver City, California); Joseph P. Dunham (Glendale, California) |
| ABSTRACT | Described herein is a method to create dendritic biocompatible polymers from pairs of complementary dendritic nucleic acid monomers in a controlled manner, using polymerization triggers. The dendritic monomers are constituted of nucleic acids and an organic polymer capable of self-assembly. Each polymer contains approximately 200 dendrites that can be used to attach labels and constitute a biologically compatible signal amplification technology. Depending on the context this technology could be used to reveal the presence of a large variety of analytes such as specific nucleic acid molecules, small molecules, proteins, and peptides. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/047215 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 2310/531 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) Original (OR) Class C12Q 1/6834 (20130101) C12Q 1/6841 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193387 | RABINOWITZ et al. |
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| FUNDED BY |
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| APPLICANT(S) | Natera, Inc. (San Carlos, California) |
| ASSIGNEE(S) | Natera, Inc. (San Carlos, California) |
| INVENTOR(S) | Matthew RABINOWITZ (San Francisco, California); Milena BANJEVIC (Los Altos Hills, California); Zachary DEMKO (San Francisco, California); David JOHNSON (San Francisco, California); Dusan KIJACIC (Los Altos Hills, California); Dimitri PETROV (Stanford, California); Joshua SWEETKIND-SINGER (San Jose, California); Jing XU (Jersey City, New Jersey) |
| ABSTRACT | Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836610 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2537/149 (20130101) C12Q 2545/114 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 25/00 (20190201) G16B 30/00 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193396 | Chowdhury et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Medical University of Lodz (Lodz, Poland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dipanjan Chowdhury (Brookline, Massachusetts); Kevin M. Elias (Brookline, Massachusetts); Wojciech Fendler (Lodz, Poland); Konrad Stawiski (Lodz, Poland) |
| ABSTRACT | Provided herein are methods and kits for determining the presence or absence of certain microRNA biomarkers in a blood sample of a female patient. The microRNA biomarkers are associated with ovarian cancer. Also provided are methods for screening a female subject for the presence or absence of certain microRNA biomarkers, as well as methods for treating a female subject having an ovarian cancer. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/810495 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193400 | Kelsey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNIVERSITY OF KANSAS (Lawrence, Kansas); THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl Kelsey (Brookline, Massachusetts); John Wiencke (San Francisco, California); Devin Koestler (Kansas City, Kansas); Brock Christensen (West Lebanon, New Hampshire) |
| ABSTRACT | Ratio of neutrophils to lymphocytes (NLR) is here associated with immune suppression and decreased survival times in multiple solid tumors. Based on immune cell-specific DMRs and validated cell deconvolution algorithms, the NLR in blood from glioma patients was estimated and glioma patients had elevated mdNLR scores compared to controls. The patient mdNLR scores were increased in patients with grade IV tumors compared to grade II/III. High mdNLR scores were associated with shorter survival. Candidate single (myeloid-associated) gene loci that were highly correlated with the mdNLR were identified. Single myeloid differentiation loci provide a simpler and cheaper alternative to the mdNLR, which requires complex array data. Immunomethylomics are useful and more convenient than conventional cell analysis in profiling glioma risk and survival. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937087 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6837 (20130101) C12Q 1/6881 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/154 (20130101) Electric Digital Data Processing G06F 17/18 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193409 | Meeske et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE ROCKEFELLER UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Meeske (New York, New York); Luciano Marraffini (New York, New York) |
| ABSTRACT | Provided is an anti-CRISPR protein (AcrVIA1), which acts as an inhibitor of the nuclease of Cas13. Cas13 recognizes complementary viral transcripts to trigger the degradation of both host and viral RNA during the type VI CRISPR-Cas antiviral response. AcrVIA1 is provided as an isolated or recombinantly expressed protein comprising the sequence of SEQ ID NO:1, or derivatives thereof, expression vectors that encode the same sequence, and methods of making and using proteins that comprise the same sequence, or derivatives thereof, for inhibiting the function of Cas13 and/or protein complexes and/or ribonucleoprotein complexes that comprise Cas13. The disclosure further includes use of the described inhibitor protein in improved diagnostic assays that include Cas13. Inclusion of the inhibitor is expected to preclude a requirement to reverse transcribe and/or create cDNA amplifications of the particular RNA that is the subject of the analysis. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/995401 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1048 (20130101) C12N 15/1055 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194427 | Alexandros et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandros Alexandros (New York, New York); Guanshi WANG (Mew York, New York) |
| ABSTRACT | Described herein are 3D single-molecule super-resolution imaging systems and methods. The provided systems and methods use modulation interferometry and phase-sensitive detection techniques that achieve less than 2 nanometer axial localization precision, which is well below the 5-10-nanometer-sized individual protein components. To illustrate the capability of this technique in probing the dynamics of complex macromolecular machines, (1) movement of individual multi-subunit E. coli RNA Polymerases were visualized through the complete transcription cycle, (2) kinetics of the initiation-elongation transition were dissected, (3) the conformational changes from the open initiation complex to the elongation complex were analyzed, and (4) the fate of σ70 initiation factors during promoter escape were determined. |
| FILED | Tuesday, December 05, 2017 |
| APPL NO | 16/608678 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6402 (20130101) G01N 21/6428 (20130101) G01N 21/6456 (20130101) Original (OR) Class G01N 2021/6439 (20130101) G01N 2201/0636 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194506 | Parigoris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Scott Parigoris (Atlanta, Georgia); Ji Hoon Lee (Atlanta, Georgia); Soojung Lee (Atlanta, Georgia); David Mertz (Atlanta, Georgia); Shuichi Takayama (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a 3D structure comprising a tissue layer having a first surface defining an interior chamber and an opposing second surface supporting a first plurality of cells outwardly positioned from the interior chamber, wherein the interior chamber comprises an extracellular matrix mixture. The present disclosure also provides a method of making a 3D structure, the method comprising mixing an extracellular matrix mixture at a first temperature with a culture medium at a second temperature, the second temperature greater than the first temperature, culturing a first plurality of cells in the extracellular matrix mixture and culture medium, and forming a 3D structure having an interior chamber enclosed by the first plurality of cells configured to interface with an environment external to the 3D structure. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/925998 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) C12N 2501/11 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194524 | Hedrick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | La Jolla Institute for Immunology (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Catherine Lynn Hedrick (La Jolla, California); Lindsey Padgett (La Jolla, California) |
| ABSTRACT | A method of diagnosing and treating a cardiovascular disease in a patient, the method comprising the steps of: determining whether the patient has an increase in stem cell memory T (Tscm) cells by: obtaining or having obtained a biological sample from the patient; performing or having performed an assay on the biological sample to determine the amount of Tscm in the patient, wherein the T scm are at least one of: CD8+CD45RA+CCR7+CD27+CD28+CD95+ T cells, CD4+CD45RA+CCR7+CD27+CD28+CD95+ T cells, or CD8+CD3+CD45RA+CCR7+C D45RO− CD95+ T cells; identifying that the patient has an increase in Tscm when compared to the amount of Tscm in a healthy patient; and if the patient has an increase in Tscm, then administering therapy for the treatment of the cardiovascular disease to the patient. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/776417 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) G01N 33/56972 (20130101) Original (OR) Class G01N 2333/705 (20130101) G01N 2800/32 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194544 | Bhatia et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Sangeeta N. Bhatia (Lexington, Massachusetts); Geoffrey A. von Maltzahn (Boston, Massachusetts); Gabriel A. Kwong (Atlanta, Georgia) |
| ABSTRACT | The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 18/056752 |
| CURRENT CPC | Peptides C07K 7/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) C12Q 1/56 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) G01N 33/6848 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194545 | Hahn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Sihoun Hahn (Clyde Hill, Washington); Christopher Collins (Seattle, Washington); Fan Yi (Shoreline, Washington); Remwilyn Dayuha (Lynnwood, Washington) |
| ABSTRACT | The current disclosure provides antibodies that bind to peptides associated with the primary immunodeficiency disorders (PIDD) Wiskott-Aldrich Syndrome (WAS) and X-linked agammaglobulinemia (XLA). The antibodies can be used in peptide immunoaffinity enrichment coupled to selected reaction monitoring mass spectrometry (immuno-SRM) assays for clinical diagnosis and newborn screening of WAS and XLA, among other uses. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/995261 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/6854 (20130101) Original (OR) Class G01N 2333/4703 (20130101) G01N 2800/24 (20130101) G01N 2800/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194640 | CHRISTODOULOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony CHRISTODOULOU (Los Angeles, California); Debiao LI (Los Angeles, California); Yuhua CHEN (Los Angeles, California) |
| ABSTRACT | A method for performing magnetic resonance imaging on a subject comprises obtaining undersampled imaging data, extracting one or more temporal basis functions from the imaging data, extracting one or more preliminary spatial weighting functions from the imaging data, inputting the one or more preliminary spatial weighting functions into a neural network to produce one or more final spatial weighting functions, and multiplying the one or more final spatial weighting functions by the one or more temporal basis functions to generate an image sequence. Each of the temporal basis functions corresponds to at least one time-varying dimension of the subject. Each of the preliminary spatial weighting functions corresponds to a spatially-varying dimension of the subject. Each of the final spatial weighting functions is an artifact-free estimation of the one of the one or more preliminary spatial weighting functions. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/642016 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/483 (20130101) G01R 33/5608 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194641 | Nezafat et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reza Nezafat (Newton, Massachusetts); Rui Guo (Jamaica Plain, Massachusetts) |
| ABSTRACT | A system for quantitative parameter mapping using magnetic resonance (MR) image includes an input for receiving a plurality of weighted MR images of a subject and a corresponding at least one imaging parameter for the plurality of weighted MR images, and a quantitative parameter mapping neural network coupled to the input and configured to estimate at least one tissue parameter and generate at least one quantitative map for the at least one tissue parameter based on the plurality of weighted MR images of the subject and the corresponding at least one imaging parameter. The quantitative parameter mapping neural network can be trained using a set of training data utilizing at least one confounder for the quantification of the at least one tissue parameter. The system can further include a display coupled to the quantitative parameter mapping neural network to display the at least one quantitative map. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067489 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/5608 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0455 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230195763 | Ning et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xia Ning (Columbus, Ohio); Zhiyun Ren (Sunnyvale, California); Bo Peng (Columbus, Ohio); Titus K. Schleyer (Indianapolis, Indiana) |
| ABSTRACT | Disclosed embodiments include computer-implemented methods and systems that can efficiently generate highly relevant recommended search terms to clinicians. A hybrid collaborative filtering model recommends search terms for a specific patient to the clinician. The model draws on information from patients' clinical encounters and the searches that were performed during the clinical encounters. To generate recommendations, the model uses search terms which are (1) frequently co-occurring with the ICD codes recorded for the patient and (2) highly relevant to the most recent search terms. One variation of the model uses only the most recent ICD codes assigned to the patient. Another variation uses all ICD codes. Comprehensive experiments of embodiments of the methods and systems have demonstrate high levels of performance. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063144 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/337 (20190101) G06F 16/3322 (20190101) Original (OR) Class G06F 16/3334 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230196642 | Hosseinzadeh Taher et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Reza Hosseinzadeh Taher (Tempe, Arizona); Fatemeh Haghighi (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | A self-supervised learning framework for empowering instance discrimination in medical imaging using Context-Aware instance Discrimination (CAiD), in which the trained deep models are then utilized for the processing of medical imaging. An exemplary system receives a plurality of medical images; trains a self-supervised learning framework to increasing instance discrimination for medical imaging using a Context-Aware instance Discrimination (CAiD) model using the received plurality of medical images; generates multiple cropped image samples and augments samples using image distortion; applies instance discrimination learning a mapping back to a corresponding original image; reconstructs the cropped image samples and applies an auxiliary context-aware learning loss operation; and generates as output, a pre-trained CAiD model based on the application of both (i) the instance discrimination learning and (ii) the auxiliary context-aware learning loss operation. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/085145 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 11/008 (20130101) Original (OR) Class G06T 2207/10116 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2210/22 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230196839 | Marshall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Duke University (Durham, North Carolina) |
| INVENTOR(S) | Jesse Marshall (Cambridge, Massachusetts); Timothy William Dunn (Cambridge, Massachusetts); Bence Olveczky (Cambridge, Massachusetts); Diego Aldarondo (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for performing long-term kinematic tracking of an animal subject are provided. Chronically-affixed motion capture markers including a tissue engaging feature and a reflective marker are described, the motion capture markers enabling long-term motion capture recording of an animal subject. A method of determining a three-dimensional pose of a subject using a trained statistical model configured to generate landmark position data associated with the three-dimensional pose of the animal subject. The method includes using projective geometry to generate three-dimensional image volumes as input to the trained statistical model. Further, a method for profiling a subject’s physical behavior over a period of time by applying clustering to information indicative of movement of the subject over the period of time is described. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/063953 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/73 (20170101) G06T 2207/10016 (20130101) G06T 2207/20084 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 20/40 (20220101) G06V 40/23 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197204 | Montserrat et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Mas Montserrat (Stanford, California); Alexander Ioannidis (Stanford, California); Arvind Kumar (Stanford, California); Carlos Bustamante (Berkeley, California); Richa Rastogi (Stanford, California); Helgi Hilmarsson (Stanford, California) |
| ABSTRACT | A computer-implemented method comprises: storing a trained machine learning model, the machine learning model comprising a predictor sub-model and a smoothing sub-model, the machine learning model being trained based on segments of training genomic sequences that have known ancestral origins; receiving data representing an input genomic sequence of the subject, the input genomic sequence covering a plurality of segments including a plurality of single nucleotide polymorplasms (SNP) sites of the genome of the subject, wherein each segment comprises a sequence of SNP values at the SNP sites, each SNP value specifying a variant at the SNP site; determining, using the predictor sub-model and based on the data, an initial ancestral origin estimate of each segment of SNP values; and performing, by the smoothing sub-model for each segment, a smoothing operation over the initial ancestral origin estimates to obtain a final prediction result for the ancestral origin of the segment. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/996183 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/20 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) G16B 40/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198534 | HASHEMI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University Of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hossein HASHEMI (Los Angeles, California); Aria SAMIEI (Los Angeles, California) |
| ABSTRACT | A system and method for reducing or eliminating undesired effects of an artifact on a received signal is disclosed. The signal is generated from stimulating a sample. A receiver includes estimations of artifacts on the signal that are subtracted at different stages of the receiver. The estimations of the artifact may be performed via a successive approximation register scheme. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/986432 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36128 (20130101) Coding; Decoding; Code Conversion in General H03M 1/0617 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198917 | Han et al. |
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| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Han (Bridgewater, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Muhammad Bilal Anwer (Branchburg, New Jersey); Zhi-Li Zhang (Eden Prairie, Minnesota); Yang Zhang (Saint Paul, Minnesota) |
| ABSTRACT | Systems, computer-readable media, and methods are disclosed for parallel data processing for service function chains with network functions spanning multiple servers. An example system includes a first server hosting a first network function of a service function chain, a second server hosting a second network function of the service function chain, a mirror function deployed in a first switch to replicate a plurality of packets received by the system and to send respective copies of the plurality of packets to the first network function and to at least one of the second network function and a third network function of the service function chain, and a merge function deployed in a second switch to merge respective outputs of the first network function and the at least one of the second network function and the third network function. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/168553 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) G06F 2009/45595 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) H04L 41/0806 (20130101) H04L 45/64 (20130101) H04L 49/70 (20130101) H04L 49/208 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230190301 | Burkart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Joseph Thomas Burkart (Bloomfield, Indiana); Danielle E. Cafasso (Southern Pines, North Carolina); Robert Henry Hayford (Colorado Springs, Colorado); Huckelberry A. Finne (Norfolk, Virginia); Jose Ramirez Vargas (Clovis, New Mexico); Michael P. Abbott (Chesapeake, Virginia) |
| ABSTRACT | A junctional tourniquet apparatus and related methods of use. An exemplary tourniquet has an inverted cone shape, wherein a narrower end has a mushroom shaped base that is pressed against a compression target and a broader end has a plurality of pass-through slots for straps. Another exemplary tourniquet has a broad plate component and a handle component. The handle component has a mushroom shaped base on a first end and a handle on a second end. The handle component passes through the center of the plate component with threads that allow the handle component to compress a target by twisting the handle. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/097011 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1325 (20130101) Original (OR) Class A61B 17/1327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190660 | Lal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PATH (Seattle, Washington) |
| ASSIGNEE(S) | PATH (Seattle, Washington) |
| INVENTOR(S) | Manjari Lal (Redmond, Washington); Changcheng Zhu (Redmond, Washington); Thinh Le (Seattle, Washington) |
| ABSTRACT | Temperature-stable, gastric-resistant formulation suitable for oral and sustained delivery of proteins, including insulin, and for nucleic acids (e.g., DNA, RNA), and related methods of making and use are described. In an embodiment, The thermostable and acid-stable pharmaceutical composition includes an inclusion complex, where the inclusion complex includes a lipophilic active pharmaceutical ingredient-carrier ionic association complex encapsulated in a β-cyclodextrin or derivative thereof. In an embodiment, the pharmaceutical composition ion-pair complex encapsulated in the β-cyclodextrin or derivative thereof is in the form of a convenient dissolvable tablet dosage form. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/060766 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/205 (20130101) A61K 9/2018 (20130101) A61K 9/2081 (20130101) Original (OR) Class A61K 38/28 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190870 | AAKALU |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinay Kumar AAKALU (Chicago, Illinois) |
| ABSTRACT | Methods are provided for using histatins in the treatment of Neimann Pick Type C Disease and other diseases associated with TMEM97 (sigma 2 receptor) or NPC1 activity and/or cholesterol or microtubule-associated protein 1 light chain 3 accumulation. Methods for modulating TMEM97 and/or NPC1 activity in the treatment of ocular diseases is also provided. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/925361 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190930 | FERNANDES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| INVENTOR(S) | Daniel FERNANDES (Awendaw, South Carolina); Laura Schwartz (Charleston, South Carolina); Natalie Sutkowski (Charleston, South Carolina); Brian Hoel (Charleston, South Carolina); Semyon Rubinchik (Buffalo Grove, Illinois) |
| ABSTRACT | The present disclosure provides anti-nucleolin antibodies, methods of producing anti-nucleolin antibodies, and cells producing anti-nucleolin antibodies. Also provided are methods of using anti-nucleolin antibodies in treating malignant and non-malignant diseases. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/839029 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/395 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/3015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190963 | Ganesh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Karuna Ganesh (New York, New York); Manuel Valiente (Madrid, Spain); Joan Massague (New York, New York) |
| ABSTRACT | The present invention relates to methods and compositions for inhibiting metastatic spread of cancer and/or inhibiting progression of pre-existing metastatic disease in a subject using L1CAM inhibition. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 18/045357 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/519 (20130101) A61K 45/06 (20130101) A61K 48/0016 (20130101) A61K 48/0066 (20130101) Original (OR) Class A61K 48/0083 (20130101) A61K 48/0091 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191015 | DESOUZA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NxStage Medical, Inc. (Lawrence, Massachusetts) |
| ASSIGNEE(S) | NxStage Medical, Inc. (Lawrence, Massachusetts) |
| INVENTOR(S) | David DESOUZA (Essex, Massachusetts); Daniel Joseph RUBERY, JR. (Nashua, New Hampshire); Dennis M. TREU (Castle Rock, Colorado); Mark T. WYETH (Andover, Massachusetts); Jerome JAMES (Vestavia, Alabama); Garrett D. CASEY (Methuen, Massachusetts); James M. BRUGGER (Newburyport, Massachusetts); William J. SCHNELL (Libertyville, Illinois); Jeffrey H. BURBANK (Manchester, Massachusetts); Goetz FRIEDERICHS (Beverly, Massachusetts) |
| ABSTRACT | The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. |
| FILED | Wednesday, February 08, 2023 |
| APPL NO | 18/107136 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1601 (20140204) A61M 1/1647 (20140204) A61M 1/3607 (20140204) A61M 1/3663 (20130101) Original (OR) Class A61M 2205/3334 (20130101) A61M 2205/3393 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191069 | STAMLER |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan S. STAMLER (Shaker Heights, Ohio) |
| ABSTRACT | Devices for delivering a controlled concentration of an agent are provided. The device includes a reservoir for the agent and a flow control portion operably connected to the reservoir. The device also includes a valve for releasing the agent from the flow control portion and a pump for flowing air to mix with the agent released by the valve and for flowing the agent and air mixture out of the device. Methods of delivering a vaporized agent to a subject are also provided. The methods include storing a liquid agent in a reservoir of a device and flowing the agent into a flow control chamber to change the agent to a gas. The methods also include mixing the agent in gas form with air and flowing the agent and air mixture out of the device to be delivered to a subject. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/105921 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/022 (20170801) A61M 16/0057 (20130101) A61M 16/0066 (20130101) A61M 16/109 (20140204) A61M 16/125 (20140204) Original (OR) Class A61M 16/204 (20140204) A61M 16/0666 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191328 | Nocera et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Daniel G. Nocera (Cambridge, Massachusetts); Samuel S. Veroneau (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for removing a contaminant from a liquid are generally described. The liquid (e.g., water) containing the contaminant may be flowed across a semipermeable membrane (e.g., via forward osmosis) that is not permeable to the contaminant in order to remove the contaminant from the liquid. A concentration gradient across the semipermeable membrane may be provided and maintained by electrolysis of the liquid and can drive forward osmosis of the liquid through the semipermeable membrane. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/926103 |
| CURRENT CPC | Separation B01D 61/005 (20130101) Original (OR) Class B01D 61/0022 (20220801) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/445 (20130101) C02F 1/4604 (20130101) C02F 1/46104 (20130101) C02F 2103/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191479 | Agarwal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida International University Board of Trustees (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arvind Agarwal (Miami, Florida); Cheng Zhang (Miami, Florida); Tanaji Paul (Miami, Florida); Sohail Mazher Ali Khan Mohammed (Miami, Florida); Denny John (Miami, Florida) |
| ABSTRACT | Methods for large-scale additive manufacturing of high-strength boron nitride nanotubes (BNNT) / aluminum (Al) (e.g., reinforced Al alloy) metal matrix composites (MMCs) (BNNT/A1 MMCs), as well as the BNNT/A1 MMCs produced by the large-scale additive manufacturing methods, are provided. A combination of ultrasonication and spray drying techniques can produce good BNNT/Al alloy feedstock powders, which can be used in a cold spraying process. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/065796 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/103 (20220101) B22F 1/0547 (20220101) Original (OR) Class B22F 10/64 (20210101) B22F 2301/052 (20130101) B22F 2302/205 (20130101) B22F 2304/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Alloys C22C 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191978 | Wehner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Stratom, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross Wehner (Boulder, Colorado); Ryan Marsini (Frederick, Colorado); Ryan Delgizzi (Arvada, Colorado); Mark Gordon (Lafayette, Colorado); Jesse Weifenbach (Thornton, Colorado); David Regan (Arvada, Colorado); Broc Sommermeyer (Windsor, Colorado) |
| ABSTRACT | A cargo transport system is provided that has an ability to move cargo in an autonomous or semi-autonomous manner, using a compact lift vehicle capable of lifting relatively heavy objects. The system includes a cargo loading system, a sensor suite coupled with a controller, dunnage detection, cross-decking capability, cargo stacking capability, autonomous navigation, tip detection and prevention, or any combinations thereof. The system may include a fork assembly coupled with a mast and movable in a vertical direction relative to the mast. Further, the mast may be coupled with a platform or deck and movable in a horizontal direction relative to the platform, to allow the fork assembly to be lowered below a top plane of the platform when the mast is at a forward location relative to the platform. The controller and sensor suite and may provide for autonomous or semi-autonomous control and movement of the cargo transport system. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075611 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 1/36 (20130101) Original (OR) Class Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 9/10 (20130101) Motor Vehicles; Trailers B62D 55/065 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) B66F 9/195 (20130101) B66F 9/07559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192277 | Olson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Eric Stephen Olson (Fort Worth, Texas) |
| ABSTRACT | A tail rotor isolation system for rotorcraft includes a secondary engine, first and second freewheeling units, an isolation assembly and a tail rotor system. The secondary engine is coupled to the input race of the first freewheeling unit. A main rotor system is coupled to the output race of the second freewheeling unit. The isolation assembly is coupled to the output race of the first freewheeling unit and has a fully engaged position coupling the input and output races of the second freewheeling unit and a partially engaged position coupled to the input race but decoupled from the output race of the second freewheeling unit. The tail rotor system is coupled to the input race of the second freewheeling unit such that in the partially engaged position of the isolation assembly, the overrunning mode of the second freewheeling unit isolates the tail rotor system from the main rotor system. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/861702 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/12 (20130101) Original (OR) Class Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 35/08 (20130101) Couplings for Transmitting Rotation; Clutches; Brakes F16D 41/04 (20130101) F16D 2041/0603 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192280 | Cabrera et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| INVENTOR(S) | Pedro L. Cabrera (West Haven, Connecticut); David H. Hunter (Cheshire, Connecticut); David N. Schmaling (Southbury, Connecticut) |
| ABSTRACT | A rotor blade assembly connectable to a rotor hub configured to rotate about a center axis includes a torsional pitch member coupled to the rotor hub, a torque tube coupled to the torsional pitch member, wherein the torsional pitch member extends away from the center axis through a portion of the torque tube, a blade coupled to the torque tube, and a pitch control member coupled to the torque tube and configured to control a pitch angle of the blade, wherein the torsional pitch member includes a first curvilinear channel and a second curvilinear channel each having a front side and a back side, wherein the first curvilinear channel and the second curvilinear channel are disposed adjacent to each other, such that the back side of the first curvilinear channel faces the back side of the second curvilinear channel. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558191 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/10 (20130101) B64C 27/32 (20130101) Original (OR) Class B64C 27/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192601 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | David Harley Thompson (West Lafayette, Indiana); Zoltan Kalman Nagy (West Lafayette, Indiana); Ahmed Mufti (Lafayette, Indiana); Jaron Mackey (Austin, Texas) |
| ABSTRACT | The present disclosure provides processes and apparatuses for the scaled-up manufacture of lomustine via continuous flow manufacture. Such continuous flow processes may optionally include the crystallization of lomustine and the apparatuses may optionally include crystallization apparatuses/reactors in either batch or continuous flow design. In one aspect of the disclosure, a process for making lomustine is provided comprising treating solutions of 2-chloroethylisocyanate with a solution of cyclohexylamine with continuous-flow pumps in a gram-flow reactor to form a combined solution, adding deionized water with a continuous flow-pump to the combined solution to form a liquid-organic phase solution, extracting the organic phase from the solution and treating with a solution of t-butyl nitrite with a continuous flow pump in a gram flow reactor to form lomustine. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/924865 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 273/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192684 | HURYN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donna HURYN (Allentown, New Jersey); Neil HUKRIEDE (Allison Park, Pennsylvania); Keith LONG (Pittsburgh, Pennsylvania); Jagannath PANDA (Pittsburgh, Pennsylvania); Sipak JOYASAWAL (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed are substituted indole compounds and compositions. The substituted indole compounds and compositions can be used for treating or preventing acute renal failure in a subject. The compounds and compositions can also be used for treating an infectious disease or cancer. |
| FILED | Wednesday, May 27, 2020 |
| APPL NO | 17/927406 |
| CURRENT CPC | Heterocyclic Compounds C07D 209/08 (20130101) C07D 413/04 (20130101) C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192728 | Holtzman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Michael J. Holtzman (St. Louis, Missouri); Arthur G. Romero (Chesterfield, Missouri); Benjamin J. Gerovac (St. Louis, Missouri); Zhenfu Han (St. Louis, Missouri); Shamus P. Keeler (University City, Missouri); Kangyun Wu (St. Louis, Missouri) |
| ABSTRACT | Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863657 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/75 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0812 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192773 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chunfu XU (Seattle, Washington); Peilong LU (Seattle, Washington); Tamer GAMAL EL-DIN (Seattle, Washington); William A. CATTERALL (Seattle, Washington); David BAKER (Seattle, Washington) |
| ABSTRACT | Disclosed herein are polypeptide comprising an amino acid sequence at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence of any one of SEQ ID NOS: 1-4, oligomers thereof, and uses thereof. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/907302 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) Original (OR) Class C07K 14/705 (20130101) C07K 2319/03 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192824 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland) |
| ASSIGNEE(S) | United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland) |
| INVENTOR(S) | Yang Liu (North Potomac, Maryland); Stephen Savarino (Saylorsburg, Pennsylvania) |
| ABSTRACT | Antigen binding proteins that interact with class 5 ETEC adhesins, compositions comprising said antigen binding proteins, and methods of preventing or treating ETEC related disorders in a subject in need thereof comprising administering to said subject a therapeutically effective amount of one or more of said compositions are described. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/915870 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/1232 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56916 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192904 | Choudhary et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Choudhary (Boston, Massachusetts); Vika Anokhina (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to chimeric small molecules, which find utility as modifiers of target substrates according to the formula A-L1-E-B or A-L1-E-L2-B, wherein A is a kinase binding moiety; B is a target binding moiety; L1 and L2 are each a linker; and E is an electrophilic reactive group. Molecules according to the present invention find use making substrate modifications such as post-translational modifications to targets that are not the natural substrate of the kinase; accordingly, diseases or disorders may be treated or prevented with molecules of the present disclosure. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 18/057127 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0017 (20130101) Peptides C07K 16/40 (20130101) C07K 19/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192977 | Wilder |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Aleta T. Wilder (Leander, Texas) |
| ABSTRACT | A method of: providing a polymeric material, and inducing optical or acoustic phonons into the material. The inducing is performed by application of an alternating electric field or a dynamic mechanical field. When the method is performed on a polyepoxy thermoset, this may result in a water absorption rate of no more than 0.1 wt. % per 24 hours. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/066047 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/08 (20130101) C08J 5/2256 (20130101) Original (OR) Class C08J 2300/24 (20130101) C08J 2300/104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193039 | GIANNESCHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Nathan C. GIANNESCHI (Evanston, Illinois); Wei CAO (Evanston, Illinois) |
| ABSTRACT | In an aspect, an artificial selenomelanin material comprises: one or more selenomelanin polymers; wherein the one or more selenomelanin polymers comprise a plurality of covalently bonded selenomelanin base units; and wherein a chemical formula of each of the one or more selenomelanin base units comprises at least one selenium atom. Optionally, each selenomelanin polymer is a pheomelanin. Preferably, the chemical formula of each of the one or more selenomelanin base units comprises at least one covalent bond with each of the at least one selenium atom. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/770247 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 11/00 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 69/104 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193264 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael D. Lynch (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina); Eirik Moreb (Durham, North Carolina); Juliana Lebeau (Durham, North Carolina) |
| ABSTRACT | CRISPR based interference has become common in various application form genetic circuits to dynamic metabolic control. In E. coli, the native CRISPR Cascade system can be utilized for silencing by deletion of the cas3 nuclease along with expression of guide RNA arrays, where multiple genes can be silenced from a single transcript. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/906372 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/52 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193337 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Synvitrobio, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary Z. Sun (San Francisco, California); Dan E. Robertson (San Francisco, California); Kelly S. Trego (San Francisco, California); Abel C. Chiao, IV (San Francisco, California); Louis E. Metzger, IV (San Francisco, California) |
| ABSTRACT | The present disclosure relates to cell-free compositions and methods for making and using the same. In one aspect, the composition includes: an extract derived from one or more organisms; one or more proteins of interest, wherein the one or more proteins are expressed from one or more nucleic acids exogenous to the extract and/or by the one or more organisms, wherein preferably the one or more proteins react with a substrate to produce a product; and one or more O2, O—, or H2O2 scavengers. The composition may be oxygen-deprived. The composition may also include an energy recycling system. |
| FILED | Friday, October 19, 2018 |
| APPL NO | 16/757181 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/0065 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Original (OR) Class Enzymes C12Y 101/0301 (20130101) C12Y 111/01006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193362 | Pierce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Molecular Instruments, Inc. (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Niles A. Pierce (Pasadena, California); Harry Ming Tak Choi (Los Angeles, California) |
| ABSTRACT | Methods of analysis of a sample using hybridization chain reaction (HCR) are provided herein. Some embodiments involve one, two, or all three of the following aspects: 1) repeated signal detection, 2) overlapping binding sites, and 3) catalytic reporter deposition (CARD). Compositions and kits relating to these are also provided. Some embodiments encompass a method for repeated signal detection with reporter-labeled HCR hairpins involving providing a sample possibly containing one or more targets as well as possibly other molecules that are not targets, providing one or more probe sets each comprising either: a) one or more HCR initiator-labeled probes, or b) one or more probe units each comprising two or more HCR fractional initiator probes, providing one or more HCR amplifiers (each labeled with one or more reporters), detecting one or more signals from one or more reporters. In some embodiments, a probe unit comprises two or more HCR fractional initiator probes, wherein an HCR fractional initiator probe comprises a target-binding region and a fractional initiator, wherein the target-binding regions within a probe unit are configured to bind to overlapping or non-overlapping binding sites on the target, and wherein the fractional initiators on the probes within each probe unit are configured to bind to overlapping or non-overlapping binding sites on an HCR hairpin. Some embodiments encompass a method for HCR-mediated catalytic reporter deposition (CARD) for signal detection with hapten-labeled HCR hairpins involving providing a sample possibly containing one or more targets as well as possibly other molecules that are not targets, providing one or more probe sets each comprising either: a) one or more HCR initiator-labeled probes, or b) one or more probe units each comprising two or more HCR fractional initiator probes, providing one or more HCR amplifiers (each labeled with one or more haptens), providing one or more anti-haptens labeled with one or more reporter entities, wherein the reporter entity is an enzyme that mediates CARD, providing one or more CARD-substrates leading to deposition of one or more reporters, and detecting one or more signals from one or more reporters. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682336 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) Original (OR) Class C12Q 1/6825 (20130101) C12Q 1/6841 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193434 | ZHENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sea Energy (Shenzhen, China PRC); APG Galaxy Trade and Technology (Honolulu, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Songyuan ZHENG (Shenzhen, China PRC); Sheng YUAN (Shenzhen, China PRC) |
| ABSTRACT | The present application provides a solid metal material quickly soluble in water, comprising components of magnesium, gadolinium, yttrium, praseodymium, neodymium, platinum, hafnium, nickel, potassium, and manganese in a specific proportion. Furthermore, the solid metal material quickly soluble in water further comprises aluminum, copper, calcium, iron, zinc, and sodium. The present application also provides a preparation method for the solid metal material quickly soluble in water. The solid metal material quickly soluble in water provided by the present application is a quickly soluble magnesium alloy material capable of adapting to the waiting time requirement of the public for washing, can be hydrolyzed, and can react with water in a washing machine, and is environmentally friendly. Washing substances remaining on the clothes have no irritation to human skin contact, and the washing and discharging sewage discharged after washing has no harm to the environment. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/918408 |
| CURRENT CPC | Detergent Compositions; Use of Single Substances as Detergents; Soap or Soap-making; Resin Soaps; Recovery of Glycerol C11D 7/04 (20130101) C11D 11/0017 (20130101) C11D 17/06 (20130101) Alloys C22C 1/02 (20130101) C22C 23/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193762 | Molnar, JR. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel E. Molnar, JR. (Lebanon, Indiana) |
| ABSTRACT | A rotor assembly for a gas turbine engine includes a rotor extending circumferentially about a central axis. The rotor includes a ring that extends around the central axis and a mount that extends axially away from the ring. The ring includes an axially facing engagement surface. A blade extends radially outward from the ring of the rotor. A damper is coupled with the mount of the rotor and engaged with the engagement surface to minimize vibrations of the rotor assembly. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/557025 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/10 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/60 (20130101) F05D 2240/24 (20130101) F05D 2260/96 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193771 | Heeter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Heeter (Noblesville, Indiana); Daniel E. Molnar, JR. (Lebanon, Indiana) |
| ABSTRACT | A fan case assembly adapted for use with a gas turbine engine includes a fan track liner and an annular case. The fan track liner extends circumferentially at least partway about a central axis of the gas turbine engine. The annular case is configured to support the fan track liner at a radial position relative to the central axis. The fan case assembly further includes an air recirculation duct configured to redirect air around the fan track liner. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/560227 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/06 (20130101) Original (OR) Class F01D 25/26 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/60 (20130101) F05D 2240/12 (20130101) F05D 2240/14 (20130101) F05D 2260/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193778 | Heeter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Heeter (Noblesville, Indiana); Daniel E. Molnar, JR. (Lebanon, Indiana) |
| ABSTRACT | A fan case assembly adapted for use with a gas turbine engine includes a fan track liner and an annular case. The fan track liner extends circumferentially at least partway about a central axis of the gas turbine engine. The annular case is configured to support the fan track liner at a radial position relative to the central axis. The fan case assembly further includes an air recirculation duct configured to redirect air around the fan track liner. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/560230 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 21/045 (20130101) Original (OR) Class F01D 25/24 (20130101) Jet-propulsion Plants F02K 3/06 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/36 (20130101) F05D 2240/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193785 | Molnar, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel E. Molnar, JR. (Lebanon, Indiana); Robert W. Heeter (Noblesville, Indiana) |
| ABSTRACT | A fan case assembly adapted for use with a gas turbine engine includes a fan track liner and an annular case. The fan track liner extends circumferentially at least partway about a central axis of the gas turbine engine. The annular case is configured to support the fan track liner at a radial position relative to the central axis. The fan case assembly further includes an air recirculation duct configured to redirect air around the fan track liner. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/560225 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/065 (20130101) F01D 25/26 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/60 (20130101) F05D 2240/14 (20130101) F05D 2260/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193823 | Heeter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce Corporation (Indianapolis, Indiana); Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Heeter (Noblesville, Indiana); Christopher D. Hall (Indianapolis, Indiana); Daniel E. Molnar, JR. (Lebanon, Indiana) |
| ABSTRACT | An acoustic panel for a gas turbine engine, includes a panel body, a panel-body cover, and a support bracket. The panel body is configured to dampen vibrations caused by the gas turbine engine. The forward support bracket is configured to mount the acoustic panel to portions of the gas turbine engine. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/553700 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/045 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2260/963 (20130101) F05D 2300/121 (20130101) F05D 2300/603 (20130101) F05D 2300/612 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/168 (20130101) G10K 11/172 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193824 | Heeter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rolls-Royce Corporation (Indianapolis, Indiana); Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Heeter (Noblesville, Indiana); Christopher D. Hall (Indianapolis, Indiana); Daniel E. Molnar, Jr. (Lebanon, Indiana) |
| ABSTRACT | A gas turbine engine includes a fan case assembly adapted to extend around blades of a fan rotor included in the gas turbine engine. The fan case assembly includes an annular case that extends around an axis, an acoustic panel coupled to the annular case and configured to dampen vibrations and a bolting arrangement that couples the acoustic panel to the annular case. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/553701 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 2033/0206 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/243 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193940 | Jackson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | William M. Jackson (Tucson, Arizona); Raymond S. Lickson (Tucson, Arizona) |
| ABSTRACT | A sequential torque application retention system includes a driver mechanism having a shaft; a center drive coupled to a tip end; an outboard drive coupled to the tip end; a screw including a screw head with a central receiver, the central receiver corresponding to the center drive, the central receiver configured to receive the center drive; a pair of outboard receivers formed in the screw head corresponding to the outboard drive, the pair of outboard receivers configured to receive the outboard drive; wherein the center drive is engaged with the screw head at the central receiver responsive to an initial torque and the outboard drive is engaged with the screw head at the pair of outboard receivers responsive to a subsequent torque; and wherein the outboard receivers are positioned so that they do not engage with the outboard drive responsive to the initial torque. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/553230 |
| CURRENT CPC | Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 5/02 (20130101) F16B 23/0023 (20130101) F16B 23/0069 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194111 | MARSIK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Alaska Fairbanks (Fairbanks, Alaska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | TOMAS MARSIK (Fairbanks, Alaska); Riley Bickford (Fairbanks, Alaska) |
| ABSTRACT | An exemplary vent for a heat recovery ventilator is provided. The vent includes an exhaust opening and an intake opening positioned below the exhaust opening. The exhaust opening and the intake opening are configured to be coupled to an air exhaust duct and an air intake duct, respectively, of the heat recovery ventilator. A hood is positioned around the exhaust opening, the hood including a top plate, a first side plate coupled to the top plate, a second side plate coupled to the top plate, and a bottom plate coupled to the first and second side plates. Each of the top plate and the bottom plate is configured to slope downward from the exhaust opening. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/145286 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 7/06 (20130101) Original (OR) Class F24F 2007/0025 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194217 | Indelicato et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Indelicato (Crestview, Florida); Melvin White (Centerville, Ohio); David Feibus (Dayton, Ohio); Meghan Berlingo (Washington, District of Columbia); David Beargie (Crestview, Florida); Nicholas Martin (Dayton, Ohio) |
| ABSTRACT | An integrated airspace defense system for identifying and locating a suspicious unmanned aerial vehicle. The system including at least one detection device to monitor the air space and provide a detection information; a computer to process the detection information and identifying the presence of suspicious unmanned aerial vehicles (UAVs) using a sequence of detection algorithms. The integrated airspace defense system identifies and locates the suspicious UAV. In at least one embodiment the integrated airspace defense system is capable of capturing or destroying the suspicious UAV. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/168151 |
| CURRENT CPC | Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 11/02 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/04 (20200101) G01S 17/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194265 | Roumeliotis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Stergios l. Roumeliotis (Los Altos Hills, California); Kejian J. Wu (Minneapolis, Minnesota) |
| ABSTRACT | A vision-aided inertial navigation system (VINS) implements a square-root multi- state constraint Kalman filter (SR-MSCKF) for navigation. In one example, a processor of a VINS receives image data and motion data for a plurality of poses of a frame of reference along a trajectory. The processor executes an Extended Kalman Filter (EKF)- based estimator to compute estimates for a position and orientation for each of the plurality of poses of the frame of reference along the trajectory. For features observed from multiple poses along the trajectory, the estimator computes constraints that geometrically relate the multiple poses of the respective feature. Using the motion data and the computed constraints, the estimator computes state estimates for the position and orientation of the frame of reference. Further, the estimator determines uncertainty data for the state estimates and maintains the uncertainty data as a square root factor of a covariance matrix. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 18/045406 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/1656 (20200801) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/16 (20130101) Electric Digital Data Processing G06F 17/16 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 7/277 (20170101) G06T 2207/30241 (20130101) G06T 2207/30244 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194343 | Knaut et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Can M. Knaut (Cambridge, Massachusetts); Mikhail D. Lukin (Cambridge, Massachusetts); Marko Loncar (Cambridge, Massachusetts); Erik N. Knail (Cambridge, Massachusetts); Rivka Bekenstein (Cambridge, Massachusetts); Daniel R. Assumpcao (Cambridge, Massachusetts) |
| ABSTRACT | Sources of shaped single photons based on an integrated diamond nanophotonic system are provided. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068424 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/28 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194471 | Pansodtee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Pattawong Pansodtee (Santa Cruz, California); Mircea Teodorescu (Santa Cruz, California); Marco Rolandi (Santa Cruz, California) |
| ABSTRACT | A potentiostat is an essential piece of analytical equipment for studying electrochemical devices and reactions. As the design of electrochemical devices evolve, applications for systems with multiple working electrodes have become more common. These applications drive a need for low-cost multi-channel potentiostat systems. Embodiments describe herein include a portable, low-cost and scalable system with a modular design that can support 8 to 64 channels at a cost as low as $8 per channel. This design can replace the functionality of commercial potentiostats which cost upwards of $10k for certain applications. Each channel in the multi-channel potentiostat has an independent adjustable voltage source with a built-in ammeter and switch, making the device flexible for various configurations. The multi-channel potentiostat can be designed for low current applications (nA range), but its purpose can change by varying its shunt resistor value. The system can either function as a standalone device or remotely controlled. We demonstrate the functionality of this system for the control of a 24-channel bioelectronic ion pump for open- and closed-loop control of pH. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/084801 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/48 (20130101) Original (OR) Class G01N 27/44721 (20130101) Pulse Technique H03K 19/017509 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/144 (20130101) H05K 1/181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194492 | Strong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Veronica Strong (Portland, Oregon); Maher F. El-Kady (Los Angeles, California); Richard B. Kaner (Pacific Palisades, California) |
| ABSTRACT | An interconnected corrugated carbon-based network comprising a plurality of expanded and interconnected carbon layers is disclosed. In one embodiment, each of the expanded and interconnected carbon layers is made up of at least one corrugated carbon sheet that is one atom thick. In another embodiment, each of the expanded and interconnected carbon layers is made up of a plurality of corrugated carbon sheets that are each one atom thick. The interconnected corrugated carbon-based network is characterized by a high surface area with highly tunable electrical conductivity and electrochemical properties. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/872380 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/26 (20130101) B32B 3/28 (20130101) B32B 9/007 (20130101) B32B 9/041 (20130101) B32B 9/045 (20130101) B32B 18/00 (20130101) B32B 27/32 (20130101) B32B 2307/75 (20130101) B32B 2307/202 (20130101) B32B 2307/732 (20130101) B32B 2429/02 (20130101) B32B 2457/00 (20130101) B32B 2457/08 (20130101) B32B 2457/10 (20130101) B32B 2457/12 (20130101) B32B 2457/20 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/23 (20170801) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 2237/72 (20130101) C04B 2237/086 (20130101) C04B 2237/363 (20130101) C04B 2237/592 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0037 (20130101) Original (OR) Class Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 5/02 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) Technologies for Adaptation to Climate Change Y02A 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194634 | Clerk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aashish Clerk (Chicago, Illinois); Martin Koppenhöfer (Chicago, Illinois); Peter Groszkowski (Knoxville, Tennessee) |
| ABSTRACT | A method for quantum spin amplification includes spin-polarizing an ensemble of quantum spins in an initial spin state to generate a transversely-polarized sensing spin state. The quantum spins identically have an upper energy state and a lower energy state. The sensing spin state accumulates a phase shift that transforms the sensing spin state into a phase-accumulated spin state having first and second transverse polarization components. The phase-accumulated spin state is transformed into an intermediate spin state by rotating the first transverse polarization component into a longitudinal polarization component of the intermediate spin state. The ensemble is then coupled to an auxiliary mode, during which the intermediate spin state evolves such that the second transverse polarization component is amplified into an amplified transverse polarization. This amplified transverse polarization is then measured. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 18/057807 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0029 (20130101) Original (OR) Class G01R 33/1284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194783 | Hosseini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaveh Hosseini (Livemore, California); Omkar Karhade (Chandler, Arizona); Xiaoqian Li (Chandler, Arizona); Chia-Pin Chiu (Tempe, Arizona); Finian G. Rogers (Newbridge, Ireland) |
| ABSTRACT | An electronic device may include a photonic integrated circuit (PIC) coupled with a substrate. The PIC may communicate a photonic signal with one or more optical fibers. The PIC may process the photonic signal into an electronic signal. The PIC may extend between a first end and a second end. An electronic integrated circuit (EIC) may be coupled with the substrate. The EIC may communicate with the PIC. The EIC may transmit the electronic signal to the PIC. The EIC may receive the electronic signal from the PIC. The electronic device may include a lens assembly. The lens assembly may be coupled with the first end of the PIC. In an example, optical interconnects of the PIC are aligned with the lens assembly such that the lens assembly is configured to transmit the photonic signal communicated between PIC and the optical fibers. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557648 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/122 (20130101) Original (OR) Class G02B 6/12004 (20130101) G02B 2006/12102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230195348 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Disclosed in some examples, are methods, systems, devices, and machine readable mediums that store instructions for programmable atomic transactions in a memory of the programmable atomic unit prior to execution of the programmable atomic transaction. The memory in some examples may be an instruction RAM. The memory in some examples may be partitioned into partitions of a fixed size that stores a same number of instructions. Each programmable atomic transaction may use one or more contiguously located instruction partitions. By loading the instructions ahead of time, the instructions are ready for execution when the transaction is requested. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/870254 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/061 (20130101) G06F 3/0644 (20130101) Original (OR) Class G06F 3/0679 (20130101) G06F 12/0253 (20130101) G06F 13/1668 (20130101) G06F 2212/7205 (20130101) G06F 2213/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197308 | Black et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Adam Black (Annandale, Virginia); Jonathan Kwolek (Arlington, Virginia) |
| ABSTRACT | An atom interferometer that utilizes two counterpropagating continuous 3D-cooled atom beams which are directed into a vacuum chamber. Momentum-transfer laser (MTL) beams are directed into the atom beams to produce a predetermined recoil and subsequently generate an interference signal that is read by a photodetector and analyzed by a processor to provide information regarding inertial forces such as acceleration and rotation rate. Reversal of the recoil direction of the MTL beams allows for the suppression of errors in the measurement of the inertial forces. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066344 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/58 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/08 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/006 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197454 | Feigelson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as Represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Boris N. Feigelson (Springfield, Virginia); Alan G. Jacobs (Rockville, Maryland) |
| ABSTRACT | Methods for efficient doping of wide-bandgap (WBG) and ultrawide-bandgap (UWBG) semiconductors by implantation, and WBG and UWBG semiconductors made using the disclosed methods. A p-type semiconductor region is formed by implanting specified acceptor and donor co-dopant atoms in a predetermined ratio, e.g., two acceptors to one donor (ADA), into the semiconductor lattice. An n-type type semiconductor region is by implanting specified donor and acceptor co-dopant atoms in a predetermined ratio, e.g., two donors to one acceptor (DAD), into the semiconductor lattice. Compensator atoms are also implanted into the lattice to complete formula units in the crystal lattice structure and preserve the stoichiometry of the semiconductor material. The doped material is then annealed to activate the dopants and repair any damage to the lattice that might have occurred during implantation. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714204 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/26546 (20130101) Original (OR) Class H01L 29/24 (20130101) H01L 29/207 (20130101) H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197534 | Mastro et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Michael A. Mastro (Fairfax, Virginia); James Gallagher (Alexandria, Virginia); Travis J. Anderson (Alexandria, Virginia) |
| ABSTRACT | A computer-implemented method for evaluating a semiconductor wafer. In accordance with the present invention, using a properly designed neural network, the computer can take image data regarding the wafer at issue, plus image and electrical data regarding a prior wafer and devices fabricated on the prior wafer, to find relations to and between structural features, both known and previously unidentified, that can degrade the performance of devices fabricated on the wafer and/or can reduce the device yield of the wafer. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 18/052654 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0442 (20230101) G06N 3/0464 (20230101) Image Data Processing or Generation, in General G06T 7/001 (20130101) G06T 2207/20084 (20130101) G06T 2207/30148 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 22/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198158 | Crouch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David D. Crouch (Farragut, Tennessee); Hooman Kazemi (Thousand Oaks, California) |
| ABSTRACT | A dielectric encapsulated metal lens includes a planar conductive plate with a first surface and a second surface, wherein the first surface is parallel to the second surface; a plurality of openings from the first surface through the planar conductive plate to the second surface, wherein a longitudinal axis of each opening is perpendicular to the first surface and the second surface, wherein a size of each opening is a function of a position of said each opening on the planar conductive plate; and a dielectric material encapsulating the planar conductive plate and filing the plurality of openings, where the dielectric material forms a top surface and a bottom surface for the metal lens to reduce reflected energy. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106817 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 15/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198217 | HOHENSEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Gregory T. HOHENSEE (Nashua, New Hampshire); Peter A. BUDNI (Nashua, New Hampshire); Robert N. CAMPBELL (Corrales, New Mexico); John S. LOVELL (Corrales, New Mexico) |
| ABSTRACT | The system and method for a scalable optically pumped CO2 laser. The optically pumped CO2 laser having a Tm fiber laser configured to pump a Q-switched Ho laser that is configured to pump a molecular isotopologue mix of CO2 above atmospheric pressure, to produce a broadband, high energy, tunable output beam. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/644591 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/11 (20130101) H01S 3/13 (20130101) H01S 3/161 (20130101) H01S 3/1616 (20130101) H01S 3/1653 (20130101) H01S 3/2232 (20130101) Original (OR) Class H01S 3/06716 (20130101) H01S 3/094042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198507 | Dani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Reach Power, Inc. (Redwood City, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Asmita Dani (Redwood City, California); Christopher Joseph Davlantes (Redwood City, California) |
| ABSTRACT | A bidirectional RF circuit, preferably including a plurality of terminals, a switch, a transistor, a coupler, and a feedback network. The circuit can optionally include a drain matching network, an input matching network, and/or one or more tuning inputs. In some variations, the circuit can optionally include one or more impedance networks, such as an impedance network used in place of the feedback network; in some such variations, the circuit may not include a coupler, switch, and/or input matching network. A method for circuit operation, preferably including operating in an amplifier mode, operating in a rectifier mode, and/or transitioning between operation modes. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/087052 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/217 (20130101) Amplifiers H03F 3/19 (20130101) H03F 2200/451 (20130101) Control of Amplification H03G 3/3036 (20130101) H03G 2201/103 (20130101) H03G 2201/307 (20130101) Pulse Technique H03K 3/012 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198890 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration, Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration, Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Clifton A. Lin (Arlington, Massachusetts); Hema A. Retty (Jersey City, New Jersey) |
| ABSTRACT | A dynamic controlling framework that is adapted to dynamically optimize existing routing decisions in an optimized link state routing (OLSR) platform to favor higher-bandwidth, lower-latency links in the active link database. The dynamic controlling framework includes a link probing tool that is in communication with OLSR platform where the link probing tool is adapted to dynamically measure estimated bandwidth, latency scores, or both estimated bandwidth and latency scores of active links in the active link database of the OLSR platform. The dynamic controlling framework includes a plug-in framework that is in communication with the OLSR platform and the link probing tool where the plugin framework is adapted to receive at least one link quality multiplier (LQM) metric computed by the link probing tool and to combine the at least one LQM metric with the OLSR platform's existing link quality (LQ) metric for enhancing route selection by the OLSR platform. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/555819 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/12 (20130101) H04L 43/0864 (20130101) H04L 45/22 (20130101) H04L 45/42 (20130101) H04L 45/123 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198917 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Han (Bridgewater, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Muhammad Bilal Anwer (Branchburg, New Jersey); Zhi-Li Zhang (Eden Prairie, Minnesota); Yang Zhang (Saint Paul, Minnesota) |
| ABSTRACT | Systems, computer-readable media, and methods are disclosed for parallel data processing for service function chains with network functions spanning multiple servers. An example system includes a first server hosting a first network function of a service function chain, a second server hosting a second network function of the service function chain, a mirror function deployed in a first switch to replicate a plurality of packets received by the system and to send respective copies of the plurality of packets to the first network function and to at least one of the second network function and a third network function of the service function chain, and a merge function deployed in a second switch to merge respective outputs of the first network function and the at least one of the second network function and the third network function. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/168553 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) G06F 2009/45595 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) H04L 41/0806 (20130101) H04L 45/64 (20130101) H04L 49/70 (20130101) H04L 49/208 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230199140 | Gooden |
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| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominic R. Gooden (El Segundo, California) |
| ABSTRACT | A calibration disc for providing uniform irradiance to an optical sensor system includes a first major surface, a second major surface opposite the first major surface, and an edge surface extending around a circumference of the calibration disc. The first major surface is fully reflective and partially diffuse, the second major surface is partially reflective and partially diffuse, and the edge surface is fully reflective and partially diffuse and has an entrance aperture positioned at the edge surface and configured to receive light into the calibration disc. The first major surface, the second major surface and the edge surface are configured to scatter the light received by the entrance aperture within the calibration disc. The second major surface is configured to emit at least some of the light with uniform irradiance. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554785 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/274 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230200239 | Czubarow et al. |
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| FUNDED BY |
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| APPLICANT(S) | Pawel Czubarow (Wellesley, Massachusetts); Anthony Czubarow (Wellesley, Massachusetts); Philip Premysler (Falls Church, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pawel Czubarow (Wellesley, Massachusetts); Anthony Czubarow (Wellesley, Massachusetts); Philip Premysler (Falls Church, Virginia) |
| ABSTRACT | Methods of making various fibers are provided including co-axial fibers with oppositely doped cladding and core are provide; hollow core doped silicon carbide fibers are provided; and doubly clad PIN junction fibers are provided. Additionally methods are provided for forming direct PN junctions between oppositely doped fibers are provided. Various thermoelectric generators that incorporate the aforementioned fibers are provided. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/065529 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 41/00 (20130101) Electric solid-state devices not otherwise provided for H10N 10/13 (20230201) H10N 10/17 (20230201) Original (OR) Class H10N 10/854 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230200243 | Feigelson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Boris N. Feigelson (Springfield, Virginia); Kevin P. Anderson (Arlington, Virginia); Benjamin L. Greenberg (Alexandria, Virginia); James A. Wollmershauser (Alexandria, Virginia); Alan G. Jacobs (Rockville, Maryland) |
| ABSTRACT | Thermoelectric (TE) nanocomposite material that includes at least one component consisting of nanocrystals. A TE nanocomposite material in accordance with the present invention can include, but is not limited to, multiple nanocrystalline structures, nanocrystal networks or partial networks, or multi-component materials, with some components forming connected interpenetrating networks including nanocrystalline networks. The TE nanocomposite material can be in the form of a bulk solid having semiconductor nanocrystallites that form an electrically conductive network within the material. In other embodiments, the TE nanocomposite material can be a nanocomposite thermoelectric material having one network of p-type or n-type semiconductor domains and a low thermal conductivity semiconductor or dielectric network or domains separating the p-type or n-type domains that provides efficient phonon scattering to reduce thermal conductivity while maintaining the electrical properties of the p-type or n-type semiconductor. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061007 |
| CURRENT CPC | Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/60 (20130101) C01P 2002/88 (20130101) C01P 2004/64 (20130101) C01P 2006/32 (20130101) C01P 2006/40 (20130101) Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black; C09C 1/28 (20130101) C09C 3/006 (20130101) C09C 3/041 (20130101) C09C 3/043 (20130101) C09C 3/063 (20130101) Electric solid-state devices not otherwise provided for H10N 10/01 (20230201) H10N 10/857 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230200244 | Feigelson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Boris N. Feigelson (Springfield, Virginia); Kevin P. Anderson (Arlington, Virginia); Benjamin L. Greenberg (Alexandria, Virginia); James A. Wollmershauser (Alexandria, Virginia); Alan G. Jacobs (Rockville, Maryland) |
| ABSTRACT | Thermoelectric (TE) nanocomposite material that includes at least one component consisting of nanocrystals. A TE nanocomposite material in accordance with the present invention can include, but is not limited to, multiple nanocrystalline structures, nanocrystal networks or partial networks, or multi-component materials, with some components forming connected interpenetrating networks including nanocrystalline networks. The TE nanocomposite material can be in the form of a bulk solid having semiconductor nanocrystallites that form an electrically conductive network within the material. In other embodiments, the TE nanocomposite material can be a nanocomposite thermoelectric material having one network of p-type or n-type semiconductor domains and a low thermal conductivity semiconductor or dielectric network or domains separating the p-type or n-type domains that provides efficient phonon scattering to reduce thermal conductivity while maintaining the electrical properties of the p-type or n-type semiconductor. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061012 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/117 (20130101) C04B 35/488 (20130101) C04B 35/62813 (20130101) C04B 35/62823 (20130101) C04B 35/62884 (20130101) C04B 2235/428 (20130101) C04B 2235/3217 (20130101) C04B 2235/3244 (20130101) C04B 2235/5445 (20130101) C04B 2235/5454 (20130101) C04B 2235/9607 (20130101) Electric solid-state devices not otherwise provided for H10N 10/01 (20230201) H10N 10/857 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230200250 | Correll et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Nikolaus Correll (Boulder, Colorado); Khoi D. Ly (Boulder, Colorado); Nicholas Alexander Kellaris (Boulder, Colorado); Christoph Matthias Keplinger (Gerlingen, Germany) |
| ABSTRACT | Transducer systems disclosed herein include self-sensing capabilities. In particular, electrostatic transducers include a low voltage electrode and a high voltage electrode. A low voltage sensing unit is coupled with the low voltage electrode of the electrostatic transducer. The low voltage sensing unit is configured to measure a capacitance of the electrostatic transducer, from which displacement of the electrostatic transducer may be calculated. High voltage drive signals received by the high voltage electrode during actuation may be isolated from the low voltage sensing unit. The isolation may be provided by dielectric material of the electrostatic transducer, a voltage suppression component, and/or a voltage suppression module comprising a low impedance ground path. In the event of an electrical failure of the transducer, the low voltage sensing unit may be isolated from high voltages. |
| FILED | Saturday, May 29, 2021 |
| APPL NO | 17/928453 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/24 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/144 (20130101) Electric solid-state devices not otherwise provided for H10N 30/20 (20230201) H10N 30/802 (20230201) Original (OR) Class H10N 30/1071 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230190246 | DEARDEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Intuitive Surgical Operations, Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | Intuitive Surgical Operations, Inc. (Sunnyvale, California) |
| INVENTOR(S) | Jason DEARDEN (Provo, Utah); Jared BRUTON (Provo, Utah); Trent ZIMMERMAN (American Fork, Utah); Clayton GRAMES (East Palo Alto, California); Amelia Mariah PARKINSON (Salt Lake City, Utah); Brian D. JENSEN (Orem, Utah); Spencer P. MAGLEBY (Provo, Utah); Larry L. HOWELL (Orem, Utah) |
| ABSTRACT | The embodiments described herein can be used in a variety of sample retrieval, grasping, cutting, and manipulating operations. In some embodiments, an apparatus includes an elongated member and a retention member movably coupled to the elongated member. The elongated member includes a cutting portion configured to cut a target sample when moved, and defines an internal volume within which at least a portion of the target sample can be received. The retention member includes an engagement portion configured to move between a first position and a second position when the retention member is actuated. The engagement portion is configured to extend within the internal volume to exert a force on the target sample within the internal volume when the engagement portion is in the second position. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106723 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0275 (20130101) Original (OR) Class A61B 2010/0208 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190676 | Yost et al. |
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| FUNDED BY |
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| APPLICANT(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Yost (Charleston, South Carolina); Sarah Grace Dennis (Charleston, South Carolina); Graham Warren (Charleston, South Carolina) |
| ABSTRACT | Described herein are methods for preventing non-insulted cell damage during a subject's exposure to radiation. In some embodiments, the method can include administering an amount of poloxamer 188 or a pharmaceutical formulation thereof to a subject prior to exposure to an insult. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 18/015262 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/08 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191283 | MARCUS et al. |
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| FUNDED BY |
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| APPLICANT(S) | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CLEMSON, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. KENNETH MARCUS (CLEMSON, South Carolina); TERRI F. BRUCE (CLEMSON, South Carolina); LEI WANG (CLEMSON, South Carolina); SISI HUANG (CLEMSON, South Carolina); TYLER Y. SLONECKI (CLEMSON, South Carolina); RHONDA REIGERS POWELL (CLEMSON, South Carolina) |
| ABSTRACT | A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.) |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/108828 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/68 (20130101) Separation B01D 15/327 (20130101) Original (OR) Class Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/00 (20130101) C12N 15/10 (20130101) C12N 15/1017 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191370 | Asefa et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); Institute of Scientific Instruments of the Czech Academy of Sciences, v.v.i. (BRNO, Czech Republic) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tewodros Asefa (Piscataway, New Jersey); Tao Zhang (Piscataway, New Jersey); Eliska Materna Mikmeková (BRNO, Czech Republic); Alexei M. Tyryshkin (Piscataway, New Jersey) |
| ABSTRACT | Provided herein are TiO2-x nanoparticles and materials that show unusual photophysical and optical properties. These TiO2-x particles and materials can be used as efficient photocatalysts for the reduction of CO2 with H2O to produce CH4. Also provided herein are methods of making TiO2-x nanoparticles using a polymer-derived mesoporous carbon (PDMC) as a template. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/925372 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/063 (20130101) Original (OR) Class B01J 35/004 (20130101) B01J 35/0013 (20130101) B01J 35/1014 (20130101) B01J 35/1019 (20130101) B01J 35/1038 (20130101) B01J 35/1061 (20130101) B01J 37/086 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 23/043 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/64 (20130101) C01P 2006/12 (20130101) C01P 2006/14 (20130101) C01P 2006/16 (20130101) Acyclic or Carbocyclic Compounds C07C 1/12 (20130101) C07C 2521/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192574 | Agrawal et al. |
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| FUNDED BY |
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| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| INVENTOR(S) | Rakesh Agrawal (West Lafayette, Indiana); Zewei Chen (West Lafayette, Indiana); Peter Oladipupo (West Lafayette, Indiana) |
| ABSTRACT | Systems and processes for dehydrogenating one or more alkanes using electrically heated dehydrogenation reactors. The source of electric energy or power can be a power grid, solar panel, windmill, hydropower, nuclear power, fuel cell, gas turbines, steam turbines, portable generator or the like. The systems and processes provided herein result in a simpler dehydrogenation process which is particularly beneficial at a small scale and at remote locations, including the well site. |
| FILED | Tuesday, February 14, 2023 |
| APPL NO | 18/169086 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0013 (20130101) B01J 19/2415 (20130101) B01J 2219/00081 (20130101) B01J 2219/00085 (20130101) B01J 2219/00132 (20130101) Acyclic or Carbocyclic Compounds C07C 5/327 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192724 | Steigerwald et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Michael L. Steigerwald (New York, New York); Xavier Roy (New York, New York); Amymarie K. Bartholomew (New York, New York); Ilana B. Stone (New York, New York) |
| ABSTRACT | The present subject matter relates to photomechanical compounds and methods for producing such photomechanical materials. The compound can include a solid-state compound having a formula including [Cluster1][Cluster2]. Cluster 1 can include copper and azobenzene, and Cluster 2 can include a counterion. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/145296 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) Original (OR) Class Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192732 | Brown et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcel U. Brown (Amherst, Massachusetts); Todd Emrick (South Deerfield, Massachusetts) |
| ABSTRACT | The invention provides novel zwitterionic monomers and polymers (including copolymers) with pendent phosphonium-based zwitterionic moieties, and compositions and products comprising same, as well as related methods and uses of the compositions, for example, as surfactants, coatings, and interlayer materials, biomedical materials or agents. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/100592 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/5407 (20130101) Original (OR) Class C07F 9/5442 (20130101) Compositions of Macromolecular Compounds C08L 25/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192766 | Mozhdehi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Davoud Mozhdehi (Syracuse, New York); Md Shahadat Hossain (Syracuse, New York) |
| ASSIGNEE(S) | SYRACUSE UNIVERSITY (SYRACUSE, New York) |
| INVENTOR(S) | Davoud Mozhdehi (Syracuse, New York); Md Shahadat Hossain (Syracuse, New York) |
| ABSTRACT | A programmable assembly of proteins into well-defined nanoworms with broadened stability regimes is disclosed. Posttranslational modifications (PTMs) were used to generate lipidated proteins with precise topological and compositional asymmetry. Using an integrated experimental and computational approach, the material properties (thermoresponse and nanoscale assembly) of these hybrid amphiphiles are modulated by their amphiphilic architecture. The judicious choice of amphiphilic architecture can be used to program the assembly of proteins into adaptive nanoworms that undergo a morphological transition (sphere-to-nanoworms) in response to temperature stimuli. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 18/053517 |
| CURRENT CPC | Peptides C07K 7/06 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193032 | Fini et al. |
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| FUNDED BY |
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| APPLICANT(S) | Elham Fini (Phoenix, Arizona); Saba Shariati (Shenzhen, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elham Fini (Phoenix, Arizona); Saba Shariati (Shenzhen, China PRC) |
| ABSTRACT | Treating aged asphalt includes contacting aged asphalt with a bioagent to yield a mixture. The aged asphalt includes a siliceous stone component and bitumen, and the bioagent includes bio-oils formed from hybrid biomasses. The siliceous stone component and the bitumen are separated. The bioagent promotes separation of the siliceous stone from the bitumen. A rejuvenated bitumen composition includes recycled bitumen, virgin bitumen, and a bioagent. The recycled bitumen can be produced from recycled asphalt paving, and the bioagent can include bio-oils formed from hybrid biomasses. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/084992 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 95/00 (20130101) Original (OR) Class C08L 2555/34 (20130101) C08L 2555/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193033 | Fini et al. |
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| FUNDED BY |
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| APPLICANT(S) | Elham Fini (Phoenix, Arizona); Farideh Pahlavan (Tempe, Arizona); Albert Hung (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elham Fini (Phoenix, Arizona); Farideh Pahlavan (Tempe, Arizona); Albert Hung (Tempe, Arizona) |
| ABSTRACT | A modified bitumen composition includes bitumen, biomass oil including one or more phenolic compounds, and added sulfur. The modified bitumen composition includes between about 5 wt% and about 25 wt% of the added sulfur, at least some of the added sulfur is present as polysulfide chains, and at least some of the one or more phenolic compounds are configured to covalently bind to the polysulfide chains. Making a modified bitumen includes combining bitumen and elemental sulfur to yield sulfur-extended bitumen, and combining the sulfur-extended bitumen with biomass oil including one or more phenolic compounds to yield the modified bitumen. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/085753 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 95/00 (20130101) Original (OR) Class C08L 2555/54 (20130101) C08L 2555/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193353 | Fleischmann et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zoe Fleischmann (Flourtown, Pennsylvania); Konstantin Khrapko (Newton, Massachusetts); Dori C. Woods (Londonderry, New Hampshire); Jonathan L. Tilly (Windham, New Hampshire) |
| ABSTRACT | Disclosed are compositions and methods related to the use of plurality of reverse transcriptase primers, unique molecular identifiers (UMIs), and/or spiky primers with unique junction identifiers to improve the sequencing and amplifications methods. In some embodiments, the disclosed methods can identify sequencing errors and PCR-jumping errors. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/923700 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194266 | Roumeliotis et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minnesota, Minnesota) |
| INVENTOR(S) | Stergios I. Roumeliotis (St Paul, Minnesota); Anastasios I. Mourikis (Minneapolis, Minnesota) |
| ABSTRACT | Localization and navigation systems and techniques are described. An electronic device comprises a processor configured to maintain a state vector storing estimates for a position of the electronic device at poses along a trajectory within an environment along with estimates for positions for one or more features within the environment. The processor computes, from the image data, one or more constraints based on features observed from multiple poses of the electronic device along the trajectory, and computes updated state estimates for the position of the electronic device in accordance with the motion data and the one or more computed constraints without computing updated state estimates for the features for which the one or more constraints were computed. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051469 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/16 (20130101) G01C 21/165 (20130101) G01C 21/1656 (20200801) Original (OR) Class Systems for Controlling or Regulating Non-electric Variables G05D 1/00 (20130101) Wireless Communication Networks H04W 4/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194343 | Knaut et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Can M. Knaut (Cambridge, Massachusetts); Mikhail D. Lukin (Cambridge, Massachusetts); Marko Loncar (Cambridge, Massachusetts); Erik N. Knail (Cambridge, Massachusetts); Rivka Bekenstein (Cambridge, Massachusetts); Daniel R. Assumpcao (Cambridge, Massachusetts) |
| ABSTRACT | Sources of shaped single photons based on an integrated diamond nanophotonic system are provided. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068424 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/28 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194486 | WOLF et al. |
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| FUNDED BY |
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| APPLICANT(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian WOLF (Arlington, Virginia); Yushra F. THANZEEL (Washington, District of Columbia); Balaraman KALUVU (Arlington, Virginia) |
| ABSTRACT | The present application relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, providing certain probes; and providing an indicator. The sample is contacted with an excess of the probe under conditions to permit irreversible covalent binding of the probe to the analyte, if present in the sample. The sample is contacted with the indicator under conditions to permit covalent binding of the indicator to any excess probe that is not bound to the analyte. Based on any binding that occurs between the analyte and probe, the absolute configuration of the analyte in the sample and/or the enantiomeric composition of the analyte in the sample using a chiroptical technique is/are determined. Based on any binding that occurs between the indicator and probe, the concentration of the analyte in the sample is determined using a non-chiroptical technique. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/923446 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 31/22 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194506 | Parigoris et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Scott Parigoris (Atlanta, Georgia); Ji Hoon Lee (Atlanta, Georgia); Soojung Lee (Atlanta, Georgia); David Mertz (Atlanta, Georgia); Shuichi Takayama (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a 3D structure comprising a tissue layer having a first surface defining an interior chamber and an opposing second surface supporting a first plurality of cells outwardly positioned from the interior chamber, wherein the interior chamber comprises an extracellular matrix mixture. The present disclosure also provides a method of making a 3D structure, the method comprising mixing an extracellular matrix mixture at a first temperature with a culture medium at a second temperature, the second temperature greater than the first temperature, culturing a first plurality of cells in the extracellular matrix mixture and culture medium, and forming a 3D structure having an interior chamber enclosed by the first plurality of cells configured to interface with an environment external to the 3D structure. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/925998 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) C12N 2501/11 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230194566 — SYSTEMS AND METHODS FOR AUTOMATED TIP CONDITIONING FOR SCANNING TUNNELING SPECTROSCOPY
| US 20230194566 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Shenkai Wang (Oakland, California); Junmian Zhu (Oakland, California); Raymond Blackwell (Oakland, California); Felix Fischer (Oakland, California) |
| ABSTRACT | A scanning tunneling microscope including a z-axis scanning assembly; a quantum tunneling tip operatively connected to the z-axis scanning assembly; a z-axis controller configured to communicate with the z-axis scanning assembly; an x-y scanning assembly including a sample platform for holding a sample to be observed and arranged proximate the quantum tunneling tip separated in a z-axis direction from the platform; an x-y controller configured to communicate with the x-y scanning assembly; a measurement circuit connected to the quantum tunneling tip and the sample platform such that a relative electrical voltage is provided between said quantum tunneling tip and the sample platform and so as to measure an electrical current; and a data processor configured to communicate with the z-axis controller and the x-y controller to receive surface imaging information or point spectral information therefrom. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/084300 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 10/06 (20130101) G01Q 30/04 (20130101) Original (OR) Class G01Q 60/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230195763 | Ning et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xia Ning (Columbus, Ohio); Zhiyun Ren (Sunnyvale, California); Bo Peng (Columbus, Ohio); Titus K. Schleyer (Indianapolis, Indiana) |
| ABSTRACT | Disclosed embodiments include computer-implemented methods and systems that can efficiently generate highly relevant recommended search terms to clinicians. A hybrid collaborative filtering model recommends search terms for a specific patient to the clinician. The model draws on information from patients' clinical encounters and the searches that were performed during the clinical encounters. To generate recommendations, the model uses search terms which are (1) frequently co-occurring with the ICD codes recorded for the patient and (2) highly relevant to the most recent search terms. One variation of the model uses only the most recent ICD codes assigned to the patient. Another variation uses all ICD codes. Comprehensive experiments of embodiments of the methods and systems have demonstrate high levels of performance. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063144 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/337 (20190101) G06F 16/3322 (20190101) Original (OR) Class G06F 16/3334 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230196158 | MONROE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher MONROE (Durham, North Carolina); Or KATZ (Durham, North Carolina); Marko CETINA (Durham, North Carolina) |
| ABSTRACT | Systems and methods for producing N-body entangling interactions to simplify n-gate operations in quantum computing applications are disclosed herein. According to at least some embodiments, an oscillator generates a two-tone field tuned to qubit resonance, first upper motion-induced sidebands, first lower motion-induced sidebands, second upper motion-induced sidebands, and second lower motion-induced sidebands. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/059550 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230197207 — METHODS AND APPARATUS FOR MACHINE LEARNING ENHANCED INFRARED SPECTROSCOPY AND ANALYSIS
| US 20230197207 | Angulo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Angulo (Brooklyn, New York); Lankun Yang (Staten Island, New York); Eray S. Aydil (New York, New York); Miguel A. Modestino (New York, New York) |
| ABSTRACT | A method of training a machine learning model for determining the composition of a mixture includes obtaining, using Fourier-transform infrared (FTIR) spectroscopy, a spectrum for each of a plurality of mixtures its constituent components. A concentration of each constituent component is known for each of the plurality of mixtures. A plurality of features is extracted from each of the obtained spectra. A machine learning model is trained using the plurality of features. An apparatus for determining formation of a product includes a reactor for containing a reaction mixture and an FTIR spectrometer for producing a spectrum of a sample of the reaction mixture. A processor extracts features from the spectrum; provides the features to an ML model trained using a plurality of mixtures of the constituent components to obtain a concentration of one or more of the constituent components; and determines the formation of the product based on the concentration. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067600 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2021/3595 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/20 (20190201) G16C 20/30 (20190201) Original (OR) Class G16C 20/70 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197883 | Bharadwaj et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Shyam Bharadwaj (Ithaca, New York); Kevin Lee (Ithaca, New York); Kazuki Nomoto (Ithaca, New York); Austin Hickman (Hickman, New York); Len van Deurzen (Ithaca, New York); Huili Grace Xing (Ithaca, New York); Debdeep Jena (Ithaca, New York); Vladimir Protasenko (Ithaca, New York) |
| ABSTRACT | A method for achieving voltage-controlled gate-modulated light emission using monolithic integration of fin- and nanowire-n-i-n vertical FETs with bottom-tunnel junction planar InGaN LEDs is described. This method takes advantage of the improved performance of bottom-tunnel junction LEDs over their top-tunnel junction counterparts, while allowing for strong gate control on a low-cross-sectional area fin or wire without sacrificing LED active area as in lateral integration designs. Electrical modulation of 5 orders, and an order of magnitude of optical modulation are achieved in the device. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 18/016334 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) H01L 33/24 (20130101) H01L 33/32 (20130101) H01L 33/0041 (20130101) Original (OR) Class H01L 33/0075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198313 | NADERI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yousof NADERI (Brookline, Massachusetts); Kaushik CHOWDHURY (Needham, Massachusetts); Ufuk MUNCUK (Waltham, Massachusetts) |
| ABSTRACT | Provided herein are reconfigurable intelligent surfaces (RIS) including a surface, a source tile positioned on or proximate a first side of the surface and including a source power layer including a power amplifier and a transmitter coil configured to generate an electromagnetic field and a radio frequency (RF) layer configured to receive power from the source electromagnetic field, and a patch antenna grid for reflecting a RF signal, and a plurality of extender tiles positioned on or proximate the first side of the surface, the extender tiles each including an extender power layer including a passive transceiver coil for receiving the source electromagnetic field and relaying the source electromagnetic field as an extender electromagnetic field and an extender RF layer configured to receive power from the extender electromagnetic field, and an extender patch antenna grid for reflecting at least one of the RF signal or a second RF signal. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/086186 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 9/0407 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/005 (20200101) H02J 50/12 (20160201) H02J 50/20 (20160201) H02J 50/50 (20160201) Original (OR) Class H02J 50/402 (20200101) Transmission H04B 7/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198471 | Roblin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Roblin (Columbus, Ohio); Chenyu Liang (Columbus, Ohio) |
| ABSTRACT | Described herein is a single-input hybrid Doherty power amplifier (PA). Unlike the conventional 214 Doherty PA inverter which only performs the correct load modulation at its center frequency, the hybrid Doherty PA (HDω-PA) combiner network achieves a wideband load modulation using the frequency dependence of the electrical length of the output combiner lines versus frequency for sliding the PA mode of operation. A modified theory is presented herein to allow for a single-input PA implementation. In this design, the outphasing angle is only changing with frequency and not the input power. A transmission line phase shifter is used to provide the correct frequency-dependent input phase offset ensuring the correct wideband load modulation performed by the output combiner |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/082928 |
| CURRENT CPC | Amplifiers H03F 1/56 (20130101) H03F 1/0288 (20130101) Original (OR) Class H03F 3/245 (20130101) H03F 3/602 (20130101) H03F 2200/255 (20130101) H03F 2200/423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198534 | HASHEMI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hossein HASHEMI (Los Angeles, California); Aria SAMIEI (Los Angeles, California) |
| ABSTRACT | A system and method for reducing or eliminating undesired effects of an artifact on a received signal is disclosed. The signal is generated from stimulating a sample. A receiver includes estimations of artifacts on the signal that are subtracted at different stages of the receiver. The estimations of the artifact may be performed via a successive approximation register scheme. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/986432 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36128 (20130101) Coding; Decoding; Code Conversion in General H03M 1/0617 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198587 | Sur et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Sanjib Sur (Cayce, South Carolina); Moh. S. Saadat (West Columbia, South Carolina); Srihari Nelakuditi (Columbia, South Carolina) |
| ABSTRACT | Described herein are systems, methods and devices for implementing a temperature-aware, multi-antenna scheduler that cools mmWave devices by preventing heat buildup via switching or distributing a data stream to other redundant antennas, allowing for dissipation of heat as well as providing reliable connectivity. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/166555 |
| CURRENT CPC | Transmission H04B 7/0608 (20130101) Original (OR) Class H04B 7/0693 (20130101) Wireless Communication Networks H04W 52/0277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230198818 — Communication Devices, Systems, Software and Methods employing Symbol Waveform Hopping
| US 20230198818 | PROTHERO |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Astrapi Corporation (Dallas, Texas) |
| ASSIGNEE(S) | Astrapi Corporation (Dallas, Texas) |
| INVENTOR(S) | Jerrold PROTHERO (Delray Beach, Florida) |
| ABSTRACT | Systems, devices, and methods of the present invention facilitate secure communication by changing sets of symbol waveforms used transmit data in particular symbol times defined herein as Symbol Waveform Hopping. SWH may be enabled by selecting two or more modulation formats that have sufficiently comparable communication performance (e.g., occupied bandwidth and signal power efficiency) to enable successful sending of data between a transmitter and receiver employing SWH, but characterized by symbol waveform alphabet that include different symbol waveform, so that the overall transmission/communication performance of data stream in a signal transmission channel of the system is not significantly affected by switching between modulation formats, but one symbol waveform alphabet is not reliably able to receive signals sent using the other alphabets. Some or all of the symbol waveforms in each alphabet may not be present in other alphabets. |
| FILED | Saturday, February 11, 2023 |
| APPL NO | 18/167844 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) H04L 1/0618 (20130101) H04L 5/0023 (20130101) H04L 27/0008 (20130101) Original (OR) Class H04L 27/34 (20130101) H04L 27/2602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198917 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Han (Bridgewater, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Muhammad Bilal Anwer (Branchburg, New Jersey); Zhi-Li Zhang (Eden Prairie, Minnesota); Yang Zhang (Saint Paul, Minnesota) |
| ABSTRACT | Systems, computer-readable media, and methods are disclosed for parallel data processing for service function chains with network functions spanning multiple servers. An example system includes a first server hosting a first network function of a service function chain, a second server hosting a second network function of the service function chain, a mirror function deployed in a first switch to replicate a plurality of packets received by the system and to send respective copies of the plurality of packets to the first network function and to at least one of the second network function and a third network function of the service function chain, and a merge function deployed in a second switch to merge respective outputs of the first network function and the at least one of the second network function and the third network function. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/168553 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) G06F 2009/45595 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) H04L 41/0806 (20130101) H04L 45/64 (20130101) H04L 49/70 (20130101) H04L 49/208 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230200250 | Correll et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Nikolaus Correll (Boulder, Colorado); Khoi D. Ly (Boulder, Colorado); Nicholas Alexander Kellaris (Boulder, Colorado); Christoph Matthias Keplinger (Gerlingen, Germany) |
| ABSTRACT | Transducer systems disclosed herein include self-sensing capabilities. In particular, electrostatic transducers include a low voltage electrode and a high voltage electrode. A low voltage sensing unit is coupled with the low voltage electrode of the electrostatic transducer. The low voltage sensing unit is configured to measure a capacitance of the electrostatic transducer, from which displacement of the electrostatic transducer may be calculated. High voltage drive signals received by the high voltage electrode during actuation may be isolated from the low voltage sensing unit. The isolation may be provided by dielectric material of the electrostatic transducer, a voltage suppression component, and/or a voltage suppression module comprising a low impedance ground path. In the event of an electrical failure of the transducer, the low voltage sensing unit may be isolated from high voltages. |
| FILED | Saturday, May 29, 2021 |
| APPL NO | 17/928453 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/24 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/144 (20130101) Electric solid-state devices not otherwise provided for H10N 30/20 (20230201) H10N 30/802 (20230201) Original (OR) Class H10N 30/1071 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230191318 | Yan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Delaware (Newark, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yushan Yan (Hockessin, Delaware); Stephanie Matz (Elkton, Maryland); David Yan (Hockessin, Delaware); Rohan Razdan (Newark, Delaware); Brian Setzler (Newark, Delaware) |
| ABSTRACT | Electrochemical devices including electrochemically-driven carbon dioxide separators are disclosed, the devices including electrodes comprised of an anion exchange polymer and a charge storage compound such as nickel hydroxide and a membrane comprising an anion exchange poiymer, the membrane having a channel for inflow of a carbon dioxide-containing gas within the membrane. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/926229 |
| CURRENT CPC | Separation B01D 53/326 (20130101) Original (OR) Class B01D 2255/806 (20130101) B01D 2255/20753 (20130101) B01D 2257/504 (20130101) B01D 2258/06 (20130101) B01D 2258/0283 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0681 (20130101) H01M 12/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191324 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chao Wang (Ellicott City, Maryland); Peikun Wang (Baltimore, Maryland); Zeyuan Sun (Baltimore, Maryland); Pengfei Xie (Baltimore, Maryland); Han Zong (Baltimore, Maryland) |
| ABSTRACT | A Nitrogen Oxide (NOx) sorbent material of the present invention includes a multi-metallic oxide that includes one or more alkali or alkaline earth metal, one or more 3d transition metal, and one or more rare earth element. The NOx sorbent material is configured to adsorb and absorb NOx below a low temperature and to release the adsorbed or absorbed NOx at temperature at or above the low temperature. In some embodiments, a manganese catalyst is deposited on a high surface area carrier. The manganese catalyst takes the form of an alkali/metal promotor and an Mn-based compound. In general, the NOx sorbent material contains about one percent to about fifty percent by weight of alkali/alkaline earth metal manganese catalyst based on the total weight of the catalyst. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/926935 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 53/14 (20130101) B01D 53/8628 (20130101) Original (OR) Class B01D 2255/2073 (20130101) B01D 2257/404 (20130101) B01D 2258/01 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/34 (20130101) Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines F01N 3/0842 (20130101) F01N 2370/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230191495 | Downey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Calvin Downey (Idaho Falls, Idaho); Isabella J. van Rooyen (Idaho Falls, Idaho); Luis Nunez (Idaho Falls, Idaho) |
| ABSTRACT | A method of forming a multi-principal element alloy may include selecting a targeted composition, the targeted composition defining two or more elements and their respective proportions, determining a theoretical relative feed rate of two or more feedstock materials, determining a series of feedstock relative feed rates based on the theoretical relative feed rate, each member of the series defining a relative feed rate of the feedstock materials, forming a functionally graded material article in a directed energy deposition test process by successively matching a test deposition relative feed rate to each member of the series of feedstock relative feed rates, analyzing the functionally graded material article to determine a empirical feedstock relative feed rate of the series of feedstock relative feed rates, and forming the multi-principal element alloy in a directed energy deposition production process by matching a production deposition relative feed rate to the empirical feedstock relative feed rate. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/069023 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/30 (20210101) B22F 12/57 (20210101) B22F 12/58 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) Alloys C22C 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192675 | Sletten et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ellen M. Sletten (Los Angeles, California); Timothy M. Swager (Los Angeles, California); Justin Caram (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ellen M. Sletten (Los Angeles, California); Timothy M. Swager (Los Angeles, California); Justin Caram (Los Angeles, California) |
| ABSTRACT | Near infrared and shortwave infrared dyes can have polymethine structures. |
| FILED | Tuesday, April 03, 2018 |
| APPL NO | 16/499700 |
| CURRENT CPC | Heterocyclic Compounds C07D 311/68 (20130101) C07D 405/10 (20130101) C07D 411/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192695 | Li |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Li (Tempe, Arizona) |
| ABSTRACT | Thermally assisted delayed fluorescent materials with triad-type materials for use in full color displays and lighting applications are provided. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169289 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) C07D 471/14 (20130101) Original (OR) Class C07D 471/22 (20130101) C07D 493/22 (20130101) C07D 495/14 (20130101) C07D 495/22 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1018 (20130101) Organic electric solid-state devices H10K 50/11 (20230201) H10K 85/636 (20230201) H10K 85/657 (20230201) H10K 85/6572 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192779 | Lyman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mathew Gerald Lyman (Brentwood, California); Deon S. Anex (Livermore, California); Bonnee Rubinfeld (Danville, California) |
| ABSTRACT | Described are methods, compositions, and devices for a concatemeric protein standard that behaves as a protein but transforms into single peptides upon digestion, which is optimized to function as a non-obtrusive process control for mass spectrometry analysis. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/955214 |
| CURRENT CPC | Peptides C07K 14/245 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193148 | Ramasamy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Karthikeyan Kallupalayam Ramasamy (West Richland, Washington); Mond F. Guo (Richland, Washington); Casper O. Brady (Pasadena, California) |
| ABSTRACT | Disclosed herein are embodiments of a method for making jet fuel blendstocks that comprise partially hydrogenated carbocyclic compounds and which can be used to replace aromatic-containing fuels and that exhibit suitable seal swell properties. The disclosed method embodiments utilize catalysts and reaction conditions that facilitate partially hydrogenating carbocyclic compounds present in mixtures obtained from renewable sources, such as bio-based fermentation products. The reaction product mixtures obtained from the disclosed method can be blended with blendstocks to provide fuels that avoid soot formation caused by aromatic-containing fuels and that exhibit seal swelling that meet requirements in aviation systems. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066805 |
| CURRENT CPC | Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/16 (20130101) Original (OR) Class C10L 2230/04 (20130101) C10L 2270/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193221 | Bowie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James U. Bowie (Los Angeles, California); Meaghan Valliere (Leominster, Massachusetts); Tyler P. Korman (Sierra Madre, California); Nicholas Woodall (Knoxville, Tennessee) |
| ABSTRACT | Provided is an enzyme useful for prenylation and recombinant pathways for the production of cannabinoids, cannabinoid precursors and other prenylated chemicals in a cell free system as well and recombinant microorganisms that catalyze the reactions. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/049221 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/22 (20130101) C12P 7/42 (20130101) C12P 9/00 (20130101) C12P 17/06 (20130101) Enzymes C12Y 205/01039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193264 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael D. Lynch (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina); Eirik Moreb (Durham, North Carolina); Juliana Lebeau (Durham, North Carolina) |
| ABSTRACT | CRISPR based interference has become common in various application form genetic circuits to dynamic metabolic control. In E. coli, the native CRISPR Cascade system can be utilized for silencing by deletion of the cas3 nuclease along with expression of guide RNA arrays, where multiple genes can be silenced from a single transcript. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/906372 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/52 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230193500 | Tripathy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabhat K. Tripathy (Idaho Falls, Idaho) |
| ABSTRACT | A metal coated article includes a platinum-group metal region adjacent a refractory metal region, which is adjacent a substrate comprising an inorganic material. A refractory metal carbide layer is adjacent the substrate and the refractory metal layer is adjacent the refractory metal carbide layer. The platinum-group metal region comprises a refractory metal/platinum-group metal layer and a platinum-group metal layer. Related methods are also disclosed. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/069386 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/10 (20130101) Original (OR) Class C25D 5/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194343 | Knaut et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Can M. Knaut (Cambridge, Massachusetts); Mikhail D. Lukin (Cambridge, Massachusetts); Marko Loncar (Cambridge, Massachusetts); Erik N. Knail (Cambridge, Massachusetts); Rivka Bekenstein (Cambridge, Massachusetts); Daniel R. Assumpcao (Cambridge, Massachusetts) |
| ABSTRACT | Sources of shaped single photons based on an integrated diamond nanophotonic system are provided. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068424 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/28 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230195436 | Leidel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tactical Computing Laboratories, LLC (Muenster, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Leidel (Muenster, Texas); David Donofrio (San Francisco, California); Ryan Kabrick (New Castle, Delaware) |
| ABSTRACT | Methods for analyzing and improving a target computer application and corresponding systems and computer-readable mediums. A method includes receiving the target application. The method includes generating a parallel control flow graph (ParCFG) corresponding to the target application. The method includes analyzing the ParCFG by the computer system. The method includes generating and storing the modified ParCFG for the target application. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/645277 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/433 (20130101) Original (OR) Class G06F 8/443 (20130101) G06F 8/456 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230196502 | GUTIERREZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ADVANCED MICRO DEVICES, INC. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony GUTIERREZ (Bellevue, Washington); Muhammad Amber Hassaan (Austin, Texas); Sooraj Puthoor (Austin, Texas) |
| ABSTRACT | A processing unit includes one or more processor cores and a set of registers to store configuration information for the processing unit. The processing unit also includes a coprocessor configured to receive a request to modify a memory allocation for a kernel concurrently with the kernel executing on the at least one processor core. The coprocessor is configured to modify the memory allocation by modifying the configuration information stored in the set of registers. In some cases, initial configuration information is provided to the set of registers by a different processing unit. The initial configuration information is stored in the set of registers prior to the coprocessor modifying the configuration information. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103322 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30098 (20130101) G06F 12/02 (20130101) G06F 12/023 (20130101) Image Data Processing or Generation, in General G06T 1/20 (20130101) G06T 1/60 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197309 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Cable Technologies Corporation (Highland Heights, Kentucky); NanoAl, LLC (Skokie, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shenjia Zhang (Zionsville, Indiana); Richard Stephen Baker (Cumming, Georgia); Janusz Stanislaw Sekunda (Williamsport, Pennsylvania); Nhon Q. Vo (Winchester, Massachusetts); Francisco U. Flores (Waltham, Massachusetts) |
| ABSTRACT | Aluminum alloy wires with improved electrical conductivity and improved ultimate tensile strength are disclosed. The aluminum alloys include magnesium, silicon, and copper and are formed without a solution heat treatment. The aluminum alloy wires are useful as conductors for overhead transmission lines. Methods of making the aluminum alloy wires are further disclosed. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152490 |
| CURRENT CPC | Alloys C22C 21/02 (20130101) C22C 21/08 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/05 (20130101) C22F 1/047 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/023 (20130101) Original (OR) Class H01B 5/104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197429 | Addleman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Raymond S. Addleman (Benton City, Washington); Xiaohong Shari Li (Richland, Washington); Wilaiwan Chouyyok (Richland, Washington); David A. Atkinson (Richland, Washington) |
| ABSTRACT | A unique fiber core sampler composition, related systems, and techniques for designing, making, and using the same are described. The sampler is used to interface with existing field instrumentation, such as Ion Mobility Spectrometer (IMS) equipment. Desired sampler characteristics include its: stiffness/flexibility; thermal mass and conductivity; specific heat; trace substance collection/release dependability, sensitivity and repeatability; thickness; reusability; durability; stability for thermal cleaning; and the like. In one form the sampler has a glass fiber core with a thickness less than 0.3 millimeter that is coated with a polymer including one or more of: polymeric organofluorine, polyimide, polyamide, PolyBenzImidazole (PBI), PolyDiMethylSiloxane (PDMS), sulfonated tetrafluoroethylene (PFSA) and Poly(2,6-diphenyl-p-phenylene Oxide) (PPPO). Multiple polymer coatings with the same or different polymer types may be included, core/substrate surface functionalization utilized, and/or the core/substrate may be at partially filled with thermally conductive particles. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106937 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 3/002 (20130101) B05D 3/0218 (20130101) B05D 3/0254 (20130101) B05D 5/00 (20130101) B05D 2203/30 (20130101) B05D 2203/35 (20130101) B05D 2505/50 (20130101) B05D 2506/10 (20130101) B05D 2518/10 (20130101) B05D 2518/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/02 (20130101) G01N 1/405 (20130101) G01N 2001/007 (20130101) G01N 2001/022 (20130101) G01N 2001/024 (20130101) G01N 2001/027 (20130101) G01N 2001/028 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0409 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197436 | MAY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brelon James MAY (Idaho Falls, Idaho); David Levi YOUNG (Golden, Colorado); Aaron Joseph PTAK (Littleton, Colorado) |
| ABSTRACT | The present disclosure relates to a method that includes depositing a first layer onto a substrate, depositing a second layer onto a surface of the first layer, and separating the substrate from the second layer, where the substrate includes a first III-V alloy, the second layer includes second III-V alloy, and the first layer includes a material that includes at least two of a Group 1A element, a Group 2A element, a Group 6A element, and/or a halogen. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068735 |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 3/08 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/025 (20130101) C30B 25/186 (20130101) C30B 29/12 (20130101) C30B 29/40 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02079 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197448 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chi Zhang (Palo Alto, California); Sougata Hazra (Stanford, California); Qianying Wu (Stanford, California); Mehdi Asheghi (Oakland, California); Kenneth E. Goodson (Portola Valley, California); Ercan Dede (Ann Arbor, Michigan); James Palko (Merced, California); Sreekant Narumanchi (Littleton, Colorado) |
| ABSTRACT | We provide a novel cleanroom-based process flow that allows for easy creation of multi-level, hierarchical 3D structures in a substrate. This is achieved by introducing an ultra-thin sacrificial hardmask layer on the substrate which is first 3D patterned via multiple rounds of lithography. This 3D pattern is then scaled vertically by a factor of 200 - 300 and transferred to the substrate underneath via a single shot deep etching step. This method is also easily characterizable - using features of different topographies and dimensions, the etch rates and selectivities were quantified; this characterization information was later used while fabricating specific target structures. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/084303 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/20 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0274 (20130101) Original (OR) Class H01L 21/31144 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197933 | JOHNSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Christopher S. JOHNSON (Naperville, Illinois); Eungje LEE (Naperville, Illinois); Jinhyup HAN (Woodridge, Illinois); Jehee Park (Woodridge, Illinois) |
| ABSTRACT | Lead/lead oxide/carbon (“Pb—O—C”) nanocomposite materials that are useful as electrode active materials for electrodes in lithium and sodium batteries are formed by grinding a mixture of a lead oxide material and a carbon material in a high energy ball mill. A Pb—O—C nanocomposite as described herein comprises Pb and lead oxide nanoparticles homogeneously dispersed in a carbon nanoparticle matrix. In the nanocomposite, other elements (e.g., transition metals, Al, Si, P, Sn, Sb, and Bi) can be alloyed with the Pb nanoparticles, incorporated as a mixed oxide with the lead oxide nanoparticles, or can be present as distinct elemental or oxide nanoparticles within the carbon nanoparticle matrix. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/096768 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/57 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 10/054 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230197965 | Zhan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Pengfei Zhan (Pittsburgh, Pennsylvania); Hongying Zhou (Allison Park, Pennsylvania); Stuart D. Hellring (Pittsburgh, Pennsylvania); Fanghui Wu (Pittsburgh, Pennsylvania); Weimin Wang (San Mateo, California) |
| ABSTRACT | The present invention provides a binder composition comprising (a) a primary fluoropolymer; and (b) a secondary fluoropolymer different from the primary fluoropolymer, the secondary fluoropolymer comprising at least one perfluoropolyether segment, at least one non-fluorinated segment, and a linking group that links the perfluoropolyether segment and the non-fluorinated segment. The invention further provides slurry compositions, electrodes, and electrical storage devices. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/996243 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0404 (20130101) H01M 4/623 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198116 | Schneider et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Devin Schneider (Danville, California); Alexander Adrian Baker (Livermore, California); Jinkyu Han (San Ramon, California); Lars F. Voss (Livermore, California) |
| ABSTRACT | Disclosed are non-linear transmission lines using ferromagnetic materials to generate ferromagnetic resonance oscillations. In one aspect, a non-linear transmission line apparatus is disclosed. The apparatus includes an outer conductor having a first side and a second internally facing side, and an inner conductor positioned internal to the non-linear transmission line apparatus. The apparatus further includes a ferromagnetic material surrounding the inner conductor, wherein the ferromagnetic material comprises nanoparticles of an ε-polymorph of iron oxide expressed as ε—Fe2O3. The apparatus also includes a first dielectric material positioned between the outer conductor and the inner conductor, the dielectric material in contact with both the ferromagnetic material and with the second internally facing side of the outer conductor, wherein the outer conductor, the inner conductor, the dielectric material and the ferromagnetic material form the nonlinear transmission line. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556575 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/06 (20130101) Original (OR) Class H01P 11/005 (20130101) Pulse Technique H03K 3/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198248 | Qi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ABB S.p.A. (Sesto San Giovanni, Italy) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Li Qi (Cary, North Carolina); Yuzhi Zhang (Apex, North Carolina); Taosha Jiang (Cary, North Carolina) |
| ABSTRACT | In one aspect, a hybrid circuit protection device for current-limiting a fault current between a source and a load during a fault is provided. The hybrid circuit protection device includes an input configured to couple to the source, an output configured to couple to the load, a return configured to couple the source to the load, a main switch configured to selectively couple the input to the output, a switching network coupled in parallel with the main switch, and a controller. The controller is configured to determine that the main switch has opened in response to the fault current, where the fault current has an initial value, and activate the switching network to current-limit the fault current to less than the initial value during the fault. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557258 |
| CURRENT CPC | Emergency Protective Circuit Arrangements H02H 1/0007 (20130101) H02H 9/02 (20130101) Original (OR) Class Pulse Technique H03K 3/017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230198540 | Buckley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon Walter Buckley (Walnut Creek, California); Ryan Douglas Muir (Livermore, California) |
| ABSTRACT | Methods and devices for digitizing an analog repetitive signal using waveform averaging are described. An example method includes generating a time-varying dither signal, receiving the analog repetitive signal comprising multiple instances of a waveform, wherein each waveform has a waveform duration, wherein an average of the time-varying dither signal over multiple waveform durations is substantially zero, and wherein the time-varying dither signal varies over each waveform duration, generating a timing alignment, combining each waveform with the corresponding portion of the time-varying dither signal over each waveform duration to produce an analog output signal, converting the analog output signal to a digital output signal, and producing, based on the timing alignment, a digital averaged signal based on averaging the multiple instances of the waveform in the analog output signal, wherein the timing alignment is used to align the multiple instances of the waveform in the analog output signal. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/555270 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 1/201 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230189800 | Morra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Idaho (Mosco, Idaho) |
| ASSIGNEE(S) | University of Idaho (Moscow, Idaho) |
| INVENTOR(S) | Matthew J. Morra (Moscow, Idaho); Louise-Marie Dandurand (Moscow, Idaho); Inna E. Popova (Moscow, Idaho) |
| ABSTRACT | Disclosed herein is a method for controlling nematode populations, particularly soil nematode populations. Certain embodiments comprise applying 4-hydroxybenzylalcohol, Sinapis alba plant extract, Sinapis alba seed meal, or a combination thereof, to soil, optionally in the presence of a trap crop. A hatching factor and/or a nematicide may also be applied to the soil, either substantially simultaneously with the 4-hydroxybenzyl alcohol, Sinapis alba plant extract, Sinapis alba seed meal, or combination thereof, or sequentially in any order. Certain embodiments concern applying 4-hydroxybenzyl alcohol to soil that contains potato cyst nematode eggs. The 4-hydroxybenzyl alcohol may be obtained by an aqueous extraction of Sinapis alba plant material. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/164805 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 31/08 (20130101) Original (OR) Class A01N 65/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230190905 | SUAREZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Washington State University (Pullman, Washington); James Cook University (Cairns, Australia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CARLOS E SUAREZ (PULLMAN, Washington); JACOB M LAUGHERY (PULLMAN, Washington); REGINALDO GASPAR BASTOS (PULLMAN, Washington); MARTA GOMES DA SILVA (TÜBINGEN, Germany); HEBA FATHY ALZAN (HARM, GIZA, CAIRO, Egypt); BRIAN M COOKE (CAIRNS, Australia); VIGNESH A RATHINASAMY (CAIRNS, QUEENSLAND, Australia) |
| ABSTRACT | The present invention relates to a Babesia antigen comprising at least a portion of a gametocyte HAPLESS2/GCS1 (HAP2) protein, vectors and cells expressing such antigen, compositions and kits comprising such antigens, and methods of using such antigens to interfere with the Babesia transmission by competent ticks. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/953025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/018 (20130101) Original (OR) Class A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) Peptides C07K 14/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230192747 | Damodaran |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivasan Damodaran (Middleton, Wisconsin) |
| ABSTRACT | Conjugates of protein and polysaccharide linked by a phosphate bridge. The conjugates are made by reacting a protein with a polysaccharide in the presence of POCl3. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 18/004271 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 15/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230196599 | TAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang TAO (North Potomac, Maryland); Dongyi WANG (Fayetteville, Arkansas); Mohamed Amr ALI (Lanham, Maryland) |
| ABSTRACT | Systems, methods, and media for machine vision-guided robotic loading are provided. Such systems and methods can allow for more accurate object detection so as to allow for robotic picking or loading of an object from a pile or group of objects. In some embodiments, a camera is controlled to capture a background image of the object or group of objects. One or more illumination sources (such as, e.g., laser illuminators) are controlled to project immunization toward the object or group of objects within the field-of-view of the camera. The camera may be controlled to capture a scan image comprising the projected illumination. Based on the scan image, a depth map can be determined, which is provided to a machine learning model along with the background image. The output of the machine learning model can then provide information associated with one or more objects, such as location information, orientation information, and the like. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/963156 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1697 (20130101) Image Data Processing or Generation, in General G06T 7/593 (20170101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/141 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230194099 | Zambon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Combustion Research and Flow Technology, Inc. (Pipersville, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea C. Zambon (Philadelphia, Pennsylvania); Balaji Muralidharan (Clinton, New Jersey); William H. Calhoon, Jr. (Huntsville, Alabama); Ashvin Hosangadi (Jamison, Pennsylvania) |
| ABSTRACT | A method for designing a combustion system which emits less of at least one environmentally-harmful emission is presented. In a describing step, an injector which introduces a fuel into a combustion chamber is described via a CFD code. In a modeling step, combustion kinetics of the fuel are modeled via a pre-processing code as the fuel mixes and reacts with an oxidizer. In a first selecting step, at least one primary scalar is derived during the modeling of the combustion kinetics. In a performing step, a table look-up is performed to obtain at least one data from a look-up database based on the primary scalar. In a second selecting step, at least one secondary scalar is selected in addition to the primary scalar(s). In a specifying step, at least one chemical pathway of formation or destruction for the secondary scalar is specified via a chemistry manager wherein the secondary scalar is representative of the environmentally-harmful emission(s) of the chemical pathway(s). In a utilizing step, the data is utilized to evaluate the chemical pathway(s) to quantify the environmentally-harmful emission(s). In an identifying step, an improvement to the combustion system is identified which reduces the environmentally-harmful emission(s). |
| FILED | Friday, July 01, 2022 |
| APPL NO | 18/009118 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/22 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/42 (20130101) Original (OR) Class Electric Digital Data Processing G06F 30/17 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230194266 | Roumeliotis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minnesota, Minnesota) |
| INVENTOR(S) | Stergios I. Roumeliotis (St Paul, Minnesota); Anastasios I. Mourikis (Minneapolis, Minnesota) |
| ABSTRACT | Localization and navigation systems and techniques are described. An electronic device comprises a processor configured to maintain a state vector storing estimates for a position of the electronic device at poses along a trajectory within an environment along with estimates for positions for one or more features within the environment. The processor computes, from the image data, one or more constraints based on features observed from multiple poses of the electronic device along the trajectory, and computes updated state estimates for the position of the electronic device in accordance with the motion data and the one or more computed constraints without computing updated state estimates for the features for which the one or more constraints were computed. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051469 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/16 (20130101) G01C 21/165 (20130101) G01C 21/1656 (20200801) Original (OR) Class Systems for Controlling or Regulating Non-electric Variables G05D 1/00 (20130101) Wireless Communication Networks H04W 4/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230194589 | da Silva |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fabio Cesar Siqueira da Silva (Westminster, Colorado) |
| ABSTRACT | A mapping probe provides real-time signal sampling and recovery from engineered electromagnetic interference and includes: a trigger voltage source that synchronizes transmission of primary electromagnetic waves; primary electromagnetic wave synthesizers that receive a trigger voltage signal and produce time-varying voltage signals; transmitters that receive time-varying voltage signals and synchronously transmit primary electromagnetic waves, such that the primary electromagnetic waves are subjected to scattering by a structural entity to produce scattered electromagnetic waves; receivers that receive scattered electromagnetic waves and produce receiver signals based on the scattered electromagnetic waves; a conversion stage that receives the receiver signals and the trigger voltage signal and produces converted data; and a render that receives the converted data and produces a map of the structural entity. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/107899 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/0878 (20130101) Original (OR) Class G01R 29/0892 (20130101) G01R 31/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230195852 | Hastings |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | William Hastings (Billings, Montana) |
| ABSTRACT | An improvement to automatic classifying of threat level of objects in CT scan images of container content, methods include automatic identification of non-classifiable threat level object images, and displaying on a display of an operator a de-cluttered image, to improve operator efficiency. The de-cluttered image includes, as subject images, the non-classifiable threat level object images. Improvement to resolution of non-classifiable threat objects includes computer-directed prompts for the operator to enter information regarding the subject image and, based on same, identifying the object type. Improvement to automatic classifying of threat levels includes incremental updating the classifying, using the determined object type and the threat level of the object type. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106860 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0481 (20130101) G06F 3/0484 (20130101) G06F 18/2431 (20230101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 2200/24 (20130101) G06T 2207/10081 (20130101) G06T 2207/20092 (20130101) Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 10/768 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230190870 | AAKALU |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinay Kumar AAKALU (Chicago, Illinois) |
| ABSTRACT | Methods are provided for using histatins in the treatment of Neimann Pick Type C Disease and other diseases associated with TMEM97 (sigma 2 receptor) or NPC1 activity and/or cholesterol or microtubule-associated protein 1 light chain 3 accumulation. Methods for modulating TMEM97 and/or NPC1 activity in the treatment of ocular diseases is also provided. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/925361 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20230196158 | MONROE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher MONROE (Durham, North Carolina); Or KATZ (Durham, North Carolina); Marko CETINA (Durham, North Carolina) |
| ABSTRACT | Systems and methods for producing N-body entangling interactions to simplify n-gate operations in quantum computing applications are disclosed herein. According to at least some embodiments, an oscillator generates a two-tone field tuned to qubit resonance, first upper motion-induced sidebands, first lower motion-induced sidebands, second upper motion-induced sidebands, and second lower motion-induced sidebands. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/059550 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230191978 | Wehner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stratom, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross Wehner (Boulder, Colorado); Ryan Marsini (Frederick, Colorado); Ryan Delgizzi (Arvada, Colorado); Mark Gordon (Lafayette, Colorado); Jesse Weifenbach (Thornton, Colorado); David Regan (Arvada, Colorado); Broc Sommermeyer (Windsor, Colorado) |
| ABSTRACT | A cargo transport system is provided that has an ability to move cargo in an autonomous or semi-autonomous manner, using a compact lift vehicle capable of lifting relatively heavy objects. The system includes a cargo loading system, a sensor suite coupled with a controller, dunnage detection, cross-decking capability, cargo stacking capability, autonomous navigation, tip detection and prevention, or any combinations thereof. The system may include a fork assembly coupled with a mast and movable in a vertical direction relative to the mast. Further, the mast may be coupled with a platform or deck and movable in a horizontal direction relative to the platform, to allow the fork assembly to be lowered below a top plane of the platform when the mast is at a forward location relative to the platform. The controller and sensor suite and may provide for autonomous or semi-autonomous control and movement of the cargo transport system. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075611 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 1/36 (20130101) Original (OR) Class Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 9/10 (20130101) Motor Vehicles; Trailers B62D 55/065 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) B66F 9/195 (20130101) B66F 9/07559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230190025 | Tartal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Albert Tartal (Baltimore, Maryland); Gabriel Michael Yessin (Arlington, Virginia); Mihae Mukaida (Paonia, Colorado); Matthew Anthony Borgatti (Brooklyn, New York); John David Cranor, III (Fort Collins, Colorado); Nathan Lachenmyer (Las Vegas, Nevada) |
| ABSTRACT | An intelligent item receptacle, system, and method for providing supplemental media content in response to depositing an item having media indicia disposed thereon. An intelligent item receptacle includes an item receptacle securely enclosing an interior volume, an item sensor configured to detect an inserted item, a camera within the interior volume configured to capture an image of the item, and an output configured to play audio or visual content to bystanders outside the item receptacle. Processing circuitry within the item receptacle analyzes the image to determine if the media indicia are present on the item and, if present, causes the output to play the audio or visual content associated with the media indicia. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169690 |
| CURRENT CPC | Household or Table Equipment A47G 29/12 (20130101) A47G 29/14 (20130101) A47G 29/20 (20130101) Original (OR) Class A47G 29/1207 (20130101) A47G 29/1218 (20130101) A47G 29/12095 (20170801) Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/008 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 40/12 (20131203) Image Data Processing or Generation, in General G06T 7/20 (20130101) G06T 7/70 (20170101) Image or Video Recognition or Understanding G06V 10/12 (20220101) G06V 10/40 (20220101) G06V 10/88 (20220101) G06V 10/141 (20220101) G06V 10/147 (20220101) G06V 20/00 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230196601 | HABIB et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ayman F. HABIB (West Lafayette, India); Darcy M. BULLOCK (West Lafayette, India) |
| ABSTRACT | Systems and methods for determining the volume of a stockpile are disclosed. Embodiments include one or more detectors (sensors and/or cameras) and processing of the data gathered from the detectors in a manner that provides accurate volume estimates without requiring the exact location of the detectors. Some embodiments utilize one or more image cameras and LiDAR sensors to obtain data about the stockpile and compute the volume of the stockpile using one or more of the following procedures: segmentation of planar features from individual scans; image-based coarse registration of sensor scans at a single station; feature matching and fine registration of sensor point clouds from a single station; coarse registration of point clouds from different stations; feature matching and fine registration of sensor point clouds from different stations; and digital surface model generation for volume estimation. Some embodiments are connectable to extendable mounts and are very easy to operate. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068960 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/62 (20170101) Original (OR) Class G06T 7/74 (20170101) Image or Video Recognition or Understanding G06V 10/751 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, June 22, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230622.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page