FedInvent™ Patent Applications
Application Details for Thursday, June 29, 2023
This page was updated on Thursday, June 29, 2023 at 11:48 PM GMT
Department of Health and Human Services (HHS)
| US 20230200362 | Brock et al. |
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| FUNDED BY |
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| APPLICANT(S) | NemaMetrix, Inc (Eugene, Oregon) |
| ASSIGNEE(S) | NemaMetrix, Inc (Eugene, Oregon) |
| INVENTOR(S) | Trisha J. Brock (Eugene, Oregon); Christopher E. Hopkins (Salt Lake City, Utah); Kathryn McCormick (Eugene, Oregon) |
| ABSTRACT | This disclosure relates to methods for screening therapeutic agents to treat altered function of a mutated target gene (e.g., clinical variant) as well as reagents for use in the same. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/787899 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) Original (OR) Class A01K 2217/056 (20130101) A01K 2227/703 (20130101) A01K 2267/03 (20130101) A01K 2267/0393 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230200712 | SKIDMORE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey SKIDMORE (Galloway, Ohio); Shuman HE (Columbus, Ohio); Xia NING (Dublin, Ohio) |
| ABSTRACT | Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/927309 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/38 (20210101) Original (OR) Class A61B 5/125 (20130101) A61B 5/686 (20130101) A61B 5/4047 (20130101) A61B 5/7246 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230200716 | HERNANDEZ et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (Menands, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guillermo Horga HERNANDEZ (New York, New York); Clifford Mills CASSIDY (Ottawa, Canada); Kenneth WENGLER (New York, New York) |
| ABSTRACT | The subject matter disclosed herein relates to a method for determining dopamine function in a subject, the method comprising acquiring one or more neuromelanin-Magnetic Resonance Imaging (NM-MRI) scans of the subject's dopamine-associated brain region of interest. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/171276 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/16 (20130101) A61B 5/055 (20130101) A61B 5/4064 (20130101) Original (OR) Class A61B 5/14546 (20130101) A61B 2576/026 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/483 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230200822 | Maitland et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Texas A&M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan J. Maitland (College Station, Texas); Mark A. Wierzbicki (College Station, Texas); Landon D. Nash (College Station, Texas); Wonjun Hwang (College Station, Texas) |
| ABSTRACT | An embodiment includes a system comprising: a catheter; an optic fiber having a long axis and a short axis that is orthogonal to the long axis; first and second radiopaque elements coupled to the optic fiber; a first wire coupled to the optic fiber and extending from the first radiopaque element to the second radiopaque element; a fluid; wherein (a)(i) the first wire wraps at least partially around an exterior surface of the optic fiber; (a)(ii) an outer diameter of the first wire and an outer diameter of the optic fiber are collectively less than an inner diameter of the catheter, and (a)(iii) the first wire is configured to center the optic fiber within the catheter within a plane orthogonal to the long axis. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/167107 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/12113 (20130101) A61B 17/12181 (20130101) A61B 17/12186 (20130101) A61B 17/12195 (20130101) Original (OR) Class A61B 90/39 (20160201) A61B 2017/00867 (20130101) A61B 2017/12072 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 29/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201110 | Chae et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Je Min Chae (Lawrenceville, Georgia); Christopher Ross Ethier (Atlanta, Georgia); Jae Hwan Jung (Chungcheongnam-do, South Korea); Mark R. Prausnitz (Atlanta, Georgia) |
| ABSTRACT | Methods and compositions are provided for reducing intraocular pressure, for example in the treatment of glaucoma or ocular hypertension. The method includes introducing into a suprachoroidal space of an eye of the patient a composition effective to maintain a reduction in IOP for at least 30 days. The composition may include a cross-linked hydrogel or a material configured to crosslink or further crosslink in vivo. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/924776 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0048 (20130101) Original (OR) Class A61K 47/36 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201111 | Popov et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
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| INVENTOR(S) | Alexey Popov (Waltham, Massachusetts); Elizabeth M. Enlow (Waltham, Massachusetts); Hongming Chen (Belmont, Massachusetts); James Bourassa (Somerville, Massachusetts) |
| ABSTRACT | Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/110273 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) Original (OR) Class A61K 9/5031 (20130101) A61K 9/5123 (20130101) A61K 9/5138 (20130101) A61K 9/5146 (20130101) A61K 31/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201121 | Schwendeman et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENT OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
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| INVENTOR(S) | Steven Paul Schwendeman (Superior Township, Michigan); Ronak B. Shah (Ann Arbor, Michigan); Morgan B. Giles (Ann Arbor, Michigan); Rae Sung Chang (East Brunswick, New Jersey); Anna A. Schwendeman (Superior Township, Michigan) |
| ABSTRACT | A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/107779 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1611 (20130101) A61K 9/1623 (20130101) A61K 9/1647 (20130101) A61K 9/1652 (20130101) Original (OR) Class A61K 9/1694 (20130101) A61K 38/47 (20130101) A61K 38/1825 (20130101) A61K 38/1866 (20130101) A61K 38/2264 (20130101) Enzymes C12Y 302/01017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201128 | PAJVANI et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
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| INVENTOR(S) | Utpal PAJVANI (New York, New York); Li QIANG (Closter, New Jersey); Zhen GU (Oakland, California) |
| ABSTRACT | The method of treating obesity-induced glucose intolerance and liver fibrosis includes administering to a patient a therapeutically effective amount of a substance for inhibiting the Notch signaling pathway of the patient. The substance is formed from encapsulated γ-secretase inhibitor (GSI) nanoparticles. As a non-limiting example, each nanoparticle may be formed from a GSI, such as dibenzazepine (a bioavailable GSI) encapsulated in poly(lactic co-glycolic acid) (PLGA). The encapsulated GSI nanoparticles (GSI NPs) provide localized and effective inhibition of hepatic Notch signaling, thus improving obesity-induced glucose tolerance and liver fibrosis without intestinal side effects. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/999384 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) Original (OR) Class A61K 31/55 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201133 | Mathew |
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| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Sajish Mathew (Lexington, South Carolina) |
| ABSTRACT | Described herein are mechanistic results showing that cis- and trans-RSV have opposite effects on TyrRS-regulated neuronal DNA repair and survival, mechanistically, only cis-RSV protected neurons against stress conditions by activating TyrRS-regulated neuronal DNA repair and resilient signaling; trans-RSV, conversely, facilitated the downregulation of TyrRS resulting in the accumulation of DNA damage and subsequent neurodegeneration. Knockdown of TyrRS blunted the neuroprotective effects of cis-RSV and exacerbated the neurotoxicity by trans-RSV, providing a potential molecular basis for the controversial effects of RSV in clinical studies. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 17/974680 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201137 | Bai et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
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| INVENTOR(S) | Renyuan Bai (Baltimore, Maryland); Verena Staedtke (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods for increasing the therapeutic efficiency of oncolytic bacterial therapeutics. Bacterial oncolytic therapies, especially the ones targeting tumor hypoxia such as C. novyi-NT, often encounter incomplete tumor clearance in less hypoxic tumoral areas and severe inflammatory reactions. In this study, we explored immune-modulating preconditioning to suppress the host neutrophils and significantly enhanced the antitumor efficacy of C. novyi-NT in animal models, including an orthotopic brain tumor model in rabbits. The optimized preconditioning agent, hydroxyurea, is clinically approved and C. novyi-NT has demonstrated manageable safety and promising antitumor responses in clinical trials. Thus, the proposed preconditioning of neutrophil suppression is readily translatable to patients undergoing C. novyi-NT trials or other oncolytic biologic therapies and could improve outcome. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/085467 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/133 (20130101) Original (OR) Class A61K 31/535 (20130101) A61K 35/742 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201166 | WUCHERPFENNIG et al. |
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| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Kai WUCHERPFENNIG (Brookline, Massachusetts); Sushil KUMAR (Boston, Massachusetts); Rong En TAY (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides a method of treating a subject having a cancer. The method comprises reducing expression of a Carm 1 gene and/or a Carm 1 effector gene in a cell of the subject, and/or reducing activity of a Carm 1 protein and/or a Carm 1 effector protein in a cell of the subject. The cancer is resistant to immunotherapy and/or checkpoint blockade treatment. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/910864 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/422 (20130101) Original (OR) Class A61K 31/4409 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201171 | Husain et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Sohail Z. Husain (Mountain View, California); Monique T. Barakat (Cupertino, California) |
| ABSTRACT | Provided herein are compositions comprising a calcineurin inhibitor and a nonsteroidal anti-inflammatory drug (NSAID) and related methods of administering such compositions for preventing post-ERCP pancreatitis (PEP). |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/925985 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0031 (20130101) A61K 31/18 (20130101) A61K 31/60 (20130101) A61K 31/405 (20130101) A61K 31/436 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201173 | Fu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
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| INVENTOR(S) | Haian Fu (Decatur, Georgia); Xiulei Mo (Atlanta, Georgia); Cong Tang (Lisbon, Portugal) |
| ABSTRACT | In certain embodiments, this disclosure relates to methods of identifying cancer agents and treating cancer with identified agents. In certain embodiments, the caner agents are capable of inducing or stabilizing SMAD4 oligomerization. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/065219 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) A61K 31/437 (20130101) Original (OR) Class A61K 31/4045 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201183 | Mazzulli et al. |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Joseph Robert Mazzulli (Chicago, Illinois); Iva Stojkovska (Evanston, Illinois); Willayat Yousuf Wani (Evanston, Illinois) |
| ABSTRACT | Disclosed are methods for treating and/or preventing a disease, disorder, or condition that is associated with accumulation of α-synuclein in a subject in need thereof. The method comprises administering to the subject a therapeutically effective amount of (a) at least one ER-Golgi trafficking enhancer in combination with at least one ER protein folding enhancer, or (b) at least one N-glycosylation enhancer, or a pharmaceutical composition comprising a therapeutically effective amount of (a) at least one ER-Golgi trafficking enhancer and at least one ER protein folding enhancer, or (b) at least one N-glycosylation enhancer. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 18/056634 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) Original (OR) Class A61K 31/4709 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201187 | Levi |
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| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | Georgetown University (Washington, District of Columbia) |
| INVENTOR(S) | Moshe Levi (Washington, District of Columbia) |
| ABSTRACT | Methods of inhibiting release of one or more cytokines, or inhibiting a cytokine storm, or preventing cytokine release syndrome or a cytokines storm, in a subject infected with severe acquired respiratory syndrome coronavirus 2. The method involves administering to the subject an effective amount of one or more NAD+ precursors, one or more inhibitors of stimulator of interferon genes (STING), one or more famesoid X receptor (FXR) agonists, or a combination thereof. In addition, treatment regimens involving the use of one or more NAD+ precursors, one or more STING inhibitors, one or more FXR agonists, or a combination thereof; and kits comprising pharmaceutical compositions of one or more NAD+ precursors, one or more inhibitors of stimulator of interferon genes, one or more farnesoid X receptor agonists, or combinations thereof. |
| FILED | Saturday, May 22, 2021 |
| APPL NO | 17/926918 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) A61K 31/455 (20130101) Original (OR) Class A61K 31/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101) A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201191 | SEBTI et al. |
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| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (TAMPA, Florida); UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (ORLANDO, Florida) |
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| INVENTOR(S) | SAID M. SEBTI (TAMPA, Florida); NICHOLAS J. LAWRENCE (TAMPA, Florida); JAMES TURKSON (HONOLULU, Hawaii) |
| ABSTRACT | The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/162375 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) Original (OR) Class A61K 33/24 (20130101) A61K 33/243 (20190101) Heterocyclic Compounds C07D 295/088 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201192 | Copland, III et al. |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
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| INVENTOR(S) | John A. Copland, III (Ponte Vedra Beach, Florida); Laura Ann Marlow (Jacksonville, Florida) |
| ABSTRACT | This document relates to methods and materials involved in assessing and/or treating mammals (e.g., humans) having cancer (e.g., a SCD1-associated cancer). For example, methods for determining whether or not a cancer is likely to be responsive to one or more stearoyl CoA desaturase 1 (SCD1) polypeptide inhibitors (e.g., a selective SCD1 inhibitor (SSI)) are provided. In some cases, the methods and materials for treating a mammal by administering, to the mammal, one or more cancer treatments that is/are selected based, at least in part, on whether or not the mammal is likely to be responsive to one or more SCD1 polypeptide inhibitors e.g., SSI-4) are provided. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/928503 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201202 | WOOD et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kris WOOD (Durham, North Carolina); Kevin H. Lin (Durham, North Carolina); Justine Rutter (Durham, North Carolina); Xiaohui Hazel ANG (Durham, North Carolina) |
| ABSTRACT | The present invention provides methods for reducing the viability of cells that express PI3Kγ, treating myeloid malignancies, and sensitizing cells, particularly cancer cells that express PI3Kγ to chemotherapeutic agents. The methods comprise contacting a cell or administering to the subject a PI3K inhibitor that inhibits PI3Kγ in an isoform-specific manner. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/927575 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) A61K 31/498 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201205 | BORDBAR |
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| FUNDED BY |
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| APPLICANT(S) | Sinopia Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aarash BORDBAR (San Diego, California) |
| ABSTRACT | Disclosed herein are methods, pharmaceutical combinations, or kits for the prevention or treatment of extrapyramidal syndromes, for example, dyskinesia, dystonia, akathisia, or drug-induced Parkinsonism, with the administration of a therapeutic effective amount of Trapidil, a derivative, a metabolite, a prodrug, an analog, or a pharmaceutically acceptable salt thereof. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176962 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/53 (20130101) A61K 31/198 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) A61P 25/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201208 | Thomas et al. |
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| FUNDED BY |
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| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| INVENTOR(S) | Paul Thomas (Memphis, Tennessee); David F. Boyd (Memphis, Tennessee) |
| ABSTRACT | Provided herein are compositions containing a therapeutically effective amount of at least one ADAMTS4 inhibitor, such as a specific ADAMTS4 inhibitor, and a therapeutically effective amount of at least one antibiotic, and the use of such compositions in treating an infection in a subject in need thereof. Also disclosed herein are methods for treating an infection in a subject in need thereof, by administering to the subject a therapeutically effective amount of at least one ADAMTS4 inhibitor, such as a specific ADAMTS4 inhibitor, and a therapeutically effective amount of at least one antibiotic. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/996554 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) Original (OR) Class A61K 31/4166 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/00 (20180101) A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201211 | SHAPIRO et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul S. SHAPIRO (Baltimore, Maryland); Alexander D. MACKERELL, JR. (Baltimore, Maryland); Jeffrey D. HASDAY (Timonium, Maryland) |
| ABSTRACT | Compounds that inhibit p38α MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169785 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/54 (20130101) A61K 31/5375 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) A61P 29/00 (20180101) A61P 31/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201214 | TENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Blacksmith Medicines, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min TENG (San Diego, California); Baskar NAMMALWAR (San Diego, California); David T. PUERTA (San Diego, California) |
| ABSTRACT | Provided herein is an LpxC inhibitor compound, as well as pharmaceutical compositions comprising said compound, and methods of use thereof in the treatment of disease that would benefit from treatment with an LpxC inhibitor, including gram-negative bacterial infections such as urinary tract infections and the like. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/173207 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/5377 (20130101) Original (OR) Class A61K 47/38 (20130101) A61K 47/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201235 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); UChicago Argonne, LLC (Chicago, Illinois); Auburn University (Auburn, Alabama) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois); UChicago Argonne, LLC (Chicago, Illinois); Auburn University (Auburn, Alabama) |
| INVENTOR(S) | Youngchang Kim (Naperville, Illinois); Natalia Ivanovna Maltseva (Batavia, Illinois); Robert Jedrzejczak (Marengo, Illinois); Andrzej Joachimiak (Bolingbrook, Illinois); Jacek Wower (Auburn, Alabama); Glenn Randall (Chicago, Illinois) |
| ABSTRACT | Provided is a method of treating a disease caused by a nidovirus that encodes Nsp15, such as a coronavirus, an arterivirus, or a torovirus, in a subject in need thereof comprising administering a therapeutically effective amount of an active agent selected from 3′-uridylic acid, 5′-uridylic acid, citrate, methacycline, meclocycline sulfosalicylate, mitoxantrone, epirubicin hydrochloride, daunorubicin hydrochloride, sorafenib, sunitinib malate, primaquine diphosphate, closantel, isopropyl ester of N4-hydroxycytidine, GpU dinucleotide or derivatives thereof, and tipiracil or N-substituted derivatives thereof. Further provided are a method of inhibiting an Nsp15 endoribonuclease of a nidovirus that encodes Nsp15 and compounds of formulas (I′) and (II′). |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/926261 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/513 (20130101) A61K 31/7072 (20130101) Original (OR) Class A61K 31/7084 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201244 | Zhang |
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| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, None) |
| INVENTOR(S) | Huang-Ge Zhang (Louisville, None) |
| ABSTRACT | Provided are methods for inhibiting immune responses against microbial antigens. In some embodiments, the methods include administering to the subject a composition containing a plurality of plant-derived exosome-like particles to inhibit immune esponses against microbial antigens. Also provided are methods for inhibiting development of septic shock in subjects, for inhibiting development of cytokine storm in subjects, and for inhibiting SARS-CoV-2-induced cytopathogenic effect. Also provided are compositions that include an exosome-derived nanoparticle comprising a first lipid bilayer and a second lipid bilayer coating the exosome-like nanoparticle and/or fused with the first lipid bilayer, wherein the second lipid bilayer comprises a targeting molecule, and methods for using the compositions to treat diseases, disorders, and conditions and/or to target a therapeutic agent to a cell, tissue, and/or organ of interest. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/927111 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 31/713 (20130101) Original (OR) Class A61K 36/752 (20130101) A61K 36/8962 (20130101) A61K 36/9066 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201245 | Frydman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CZ BIOHUB SF, LLC (San Francisco, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Judith Frydman (Stanford, California); Raul Andino-Pavlovsky (Oakland, California); Ranen Aviner (Stanford, California) |
| ABSTRACT | The present disclosure provides materials and methods for treating or preventing an infection from a virus such as an RNA virus, inhibiting replication of a vims in a cell, inhibiting translation of viral proteins in a cell infected with a virus, inhibiting prolyl hydroxylation in a cell infected with a vims, preventing or inhibiting viral-induced remodeling of a polysome in a cell, and identifying a polysome-associated protein in a cell infected by a virus. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/928496 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/343 (20130101) A61K 31/713 (20130101) Original (OR) Class A61K 31/4439 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/1137 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201246 | YAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingdi YAN (Bedford, Massachusetts); William NDUGIRE (Lowell, Massachusetts); Olof RAMSTROM (Lowell, Massachusetts); N.G. Hasitha RAVIRANGA (Lowell, Massachusetts) |
| ABSTRACT | Compositions comprising metal entities in combination with an activating agent, or pharmaceutically acceptable salts thereof are disclosed. Certain compositions are active as antibacterial, antiviral, antifungal, anti-protozoal, and/or anti-worm agents. The disclosure provides pharmaceutical compositions containing the compositions. Methods of using the composition to treat bacterial infections are disclosed. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/997493 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7135 (20130101) Original (OR) Class A61K 33/242 (20190101) A61K 45/06 (20130101) A61K 47/20 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201247 | Machielse et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mandos LLC (West Hollywood, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bernardus Nicolaas Machielse (North Potomac, Maryland); Allan Darling (North Potomac, Maryland) |
| ABSTRACT | This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/115897 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 31/724 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201249 | LINHARDT et al. |
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| FUNDED BY |
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| APPLICANT(S) | Robert John LINHARDT (Albany, New York); So-Young KIM (Rockville, Maryland); Weihua JIN (Troy, New York); Jonathan Seth DORDICK (Schenectady, New York); Fuming ZHANG (Watervliet, New York); Seok-Joon KWON (Niskayuna, New York); Paul S. KWON (Niskayuna, New York); Keith FRASER (Troy, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert John LINHARDT (Albany, New York); So-Young KIM (Rockville, Maryland); Weihua JIN (Troy, New York); Jonathan Seth DORDICK (Schenectady, New York); Fuming ZHANG (Watervliet, New York); Seok-Joon KWON (Niskayuna, New York); Paul S. KWON (Niskayuna, New York); Keith FRASER (Troy, New York) |
| ABSTRACT | The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via competitive binding to SARS-CoV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-CoV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 μM, and low cytotoxicity, making it promising for clinical use. While established SARS-CoV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/915783 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) Original (OR) Class A61K 36/03 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201298 | Remaley et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Alan T. Remaley (Bethesda, Maryland); Scott M. Gordon (Lexington, Kentucky) |
| ABSTRACT | Described herein is the design and construction of a class of lipoprotein targeting protease inhibitors. Small peptides with protease inhibitor activity are conjugated to hydrophobic, lipoprotein targeting molecules using, for instance, amine reactive chemistry. Methods of use of the resultant lipoprotein targeting protease inhibitor (antiprotease) molecules are also described. Also described is the production and use of protease inhibitor enriched HDL particles, as well as AlAT-peptide-enriched HDL particles, and their use in various therapeutic contexts. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/839264 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/005 (20130101) Original (OR) Class A61K 38/07 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/58 (20130101) A61K 38/1767 (20130101) A61K 47/60 (20170801) A61K 47/545 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201315 | Somerman et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN (Bethesda, Maryland); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio); SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California); YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN (Bethesda, Maryland); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio); SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California); YALE UNIVERSITY (New Haven, Connecticut) |
| INVENTOR(S) | Martha J. Somerman (Chevy Chase, Maryland); Nadine Laure Samara (Rockville, Maryland); Atsuhiro Nagasaki (Sendai, Japan); Demetrios T. Braddock (New Haven, Connecticut); Brian Lee Foster (Hilliard, Ohio); Jose Luis Millan (San Diego, California) |
| ABSTRACT | Methods are disclosed for treating periodontal disease, peri-implantitis, or to preserve a tooth socket in a subject. These methods include selecting a subject with periodontal disease, peri-implantitis, or in need of tooth socket preservation; and locally administering into the periodontium of the subject a therapeutically effective amount of a tissue-nonspecific alkaline phosphatase (TNAP) polypeptide, or a nucleic acid molecule encoding the recombinant TNAP polypeptide. Methods are also disclosed for i) promoting alveolar bone regeneration in the subject; ii) increasing attachment of a periodontal ligament to a root surface of a tooth in the subject; iii) increasing cementum formation; and/or iv) increasing mineralization in a tooth in the subject. Pharmaceutical compositions are also disclosed that are of use in these methods. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/789742 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/46 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201327 | Collins et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Peter L. Collins (Silver Spring, Maryland); Cyril Le Nouen (Bethesda, Maryland); Ursula J. Buchholz (Silver Spring, Maryland) |
| ABSTRACT | Provided is a polynucleotide encoding a respiratory syncytial virus (RSV) variant having an attenuated phenotype comprising a modified RSV genome or antigenome that encodes a mutant RSV protein P that differs from a parental RSV protein P at one or more amino acid residues. In some embodiments, the polynucleotide is recombinant. The invention also relates to methods of vaccinating an animal with the RSV variant or a pharmaceutical composition containing the RSV variant or inducing an immune response by administering the RSV variant to an animal, and further relates to methods of producing an RSV variant vaccine. In some embodiments, the animal is a human. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/924784 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201339 | Dowling et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David J. Dowling (Brighton, Massachusetts); Ofer Levy (Cambridge, Massachusetts); Francesco Borriello (Arlington, Massachusetts) |
| ABSTRACT | Provided herein are thiazole amide compounds (e.g., Formula (I)) for use in enhancing human immune response and/or as adjuvants in vaccines. The compounds described herein are used as enhancers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease, (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease). Also provided in the present disclosure are compositions (e.g., pharmaceutical composition), kits, methods, and uses including or using compounds described herein. |
| FILED | Wednesday, September 16, 2020 |
| APPL NO | 17/761158 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 31/428 (20130101) A61K 39/0011 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 2039/55505 (20130101) A61K 2039/55511 (20130101) A61K 2039/55566 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201340 | Dowling et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David J. Dowling (Brighton, Massachusetts); Ofer Levy (Cambridge, Massachusetts); Francesco Borriello (Arlington, Massachusetts); Etsuro Nanishi (Boston, Massachusetts); Timothy O'Meara (Boston, Massachusetts); Yoshine Saito (Boston, Massachusetts); Simon D. van Haren (Wayland, Massachusetts) |
| ABSTRACT | Provided herein are adjuvantation systems for use in Beta coronavirus (e.g., MERS-CoV, SARS-CoV-1, or SARS-CoV-2) vaccines and immunogenic compositions comprising the adjuvantation system and a Beta coronavirus antigen. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/928255 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 39/215 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201341 | McNeel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas McNeel (Madison, Wisconsin); Donghwan Jeon (Madison, Wisconsin) |
| ABSTRACT | The present invention provides the combination of TLR3 agonist and TLR9 agonist can be used to increase the anti-tumor immune response to vaccines, particularly nucleic acid vaccines. Methods of treating cancer and inducing anti-tumor immune responses by treating with a TLR3 agonist and a TLR9 agonist in combination with administration of an anti-tumor vaccine are provided. The TLR3 agonist, TLR9 agonist and the vaccine may be co-administered in a unitary composition or the agonists may be administered in advance of the vaccine. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 18/053659 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 39/001193 (20180801) A61K 2039/53 (20130101) A61K 2039/55511 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201376 | SEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chandan K. SEN (Indianapolis, Indiana); Subhadip GHATAK (Indianapolis, Indiana); Sashwati ROY (Indianapolis, Indiana); Savita KHANNA (Indianapolis, Indiana) |
| ABSTRACT | Compositions and methods are provided for reprogramming demal fibroblasts to exhibit neurogenic properties including increased cell expression of NGF and Nt3 in vivo. In accordance with one embodiment such compositions are used in conjunction with standard treatment for use in treating neuropathic pain and stabilizing or stimulating production of PGP9.5+ mature nerve fiber in a diabetic patient’s tissues. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/921242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 48/0075 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201379 | Ma et al. |
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| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Ma (Belle Mead, New Jersey); Ulrich B. Wiesner (Ithaca, New York) |
| ABSTRACT | Described is a versatile surface modification approach to, for example, modularly and orthogonally functionalize nanoparticles (NPs) such as, for example, PEGylated nanoparticles, ith various types of different functional ligands (functional groups) on the NP surface. It enables the synthesis of, for example, penta-functional PEGylated nanoparticles integrating a variety of properties into a single NP, e.g., fluorescence detection, specific cell targeting, radioisotope chelating/labeling, ratiometric pH sensing, and drug delivery, while the overall NP size remains, for example, below 10 nm. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/864671 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 47/02 (20130101) A61K 47/6923 (20170801) A61K 49/0032 (20130101) A61K 49/0043 (20130101) A61K 49/0054 (20130101) A61K 49/0093 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201380 | Sillerud et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Alburquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laurel Sillerud (Albuquerque, New Mexico); Yi Yang (Albuquerque, New Mexico) |
| ABSTRACT | After a stroke the temporal course of microglial/macrophage activation is biphasic. The initial phase promotes neuroinflammation, while the later phase aids neurovascular recovery. Therefore the dynamics of stroke-induced cerebral microglial/macrophage activation are of substantial interest. In one embodiment, the present invention is directed to the use of novel anti-Iba-1-targeted superparamagnetic FePt nanoparticles immunocelles in conjunction with magnetic resonance imaging (MRI) to measure the spatiotemporal course of the activation of microglia/macrophages in brain tissue at 7, 14, and 28 days post-stroke. Ischemic cerebral lesion areas are identified using T2-weighted MR images. After injection of FePt nanoparticles as immunocelles, quantitative contrast changes in T2*-weighted MR images showed that the nanoparticles were taken up solely in brain regions that coincided with areas of microglial/macrophage activation detected by post-mortem immunohistochemistry. There was observed good agreement between the locations of the Fe+-cells, as shown by Perl's staining for iron, and the Iba-V-microgiia/macrophages, The time course of nanoparticle uptake paralleled the changes of microglial/macrophage activation and phenotypes measured by immunohistochemistry over the four week period post-stroke. Maximum microglial/macrophage activation occurred seven days post-stroke for both measures, and the diminished activation found after two weeks continued to four weeks. The results evidence that nanoparticle-enhanced MRI constitute a novel approach for monitoring the dynamic development of neuroinflammation in living animals during the progression and treatment of stroke and neurodegenerative diseases. The implications and methods for diagnosis and monitoring therapy of stroke and other disease states and conditions are presented. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/927917 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/1875 (20130101) A61K 49/1887 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201381 | Steinmetz |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California) |
| ABSTRACT | A nanoparticle for diagnostic, therapeutic, and/or theranostic applications includes a rod-shaped plant virus like particle (VLP), one or more gadolinium T1 contrast agents conjugated to an interior surface of the VLP, and a layer of polydopamine (PDA) coated over a portion of the exterior surface of the VLP. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/081916 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0052 (20130101) A61K 49/108 (20130101) A61K 49/1896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201382 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanming Wang (Beachwood, Ohio); Chunying Wu (Beachwood, Ohio) |
| ABSTRACT | A method of detecting myelin in vivo in a subject's tissue including administering to the subject a radioligand having formula (I) and detecting the location, distribution, and/or amount of the radioligand that is bound to and/or labels myelin to detect myelin in the tissue. |
| FILED | Saturday, January 21, 2023 |
| APPL NO | 18/099924 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/04 (20130101) Original (OR) Class A61K 51/0453 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 2800/52 (20130101) G01N 2800/285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201425 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher S. Chen (Newton, Massachusetts); Jan D. Baranski (Philadelphia, Pennsylvania); Ritika Chaturvedi (Philadelphia, Pennsylvania); Michael T. Yang (West Windsor, New Jersey); Kelly Stevens (Seattle, Washington); Sangeeta Bhatia (Lexington, Massachusetts) |
| ABSTRACT | The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization. |
| FILED | Wednesday, February 08, 2023 |
| APPL NO | 18/107308 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) A61L 27/40 (20130101) A61L 27/50 (20130101) Original (OR) Class A61L 27/225 (20130101) A61L 27/507 (20130101) A61L 27/3604 (20130101) A61L 27/3804 (20130101) A61L 27/3808 (20130101) A61L 27/3834 (20130101) A61L 27/3839 (20130101) A61L 27/3886 (20130101) A61L 2430/20 (20130101) A61L 2430/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201455 | Forouzandeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Farzad Forouzandeh (Rochester, New York); David Borkholder (Canandaigua, New York); Robert Frisina (Tampa, Florida); Joseph Walton (Tampa, Florida); Xiaoxia Zhu (Tampa, Florida) |
| ABSTRACT | In one embodiment, a fluid storage device includes a rigid outer housing that defines a septum cavity, a reservoir cavity, and a channel that extends between the two cavities, the outer housing further defining an outlet in fluid communication with the reservoir cavity, a septum provided within the septum cavity, the septum being made of an elastic polymer and facilitating refilling of the fluid storage device, and a thin, collapsible membrane that does not generate significant restoring forces when it is deformed as fluid is drawn from the reservoir cavity and, therefore, does not completely or partially return to its initial non-deformed shape even if the outlet of the device remains open after doses are administered. |
| FILED | Monday, February 20, 2023 |
| APPL NO | 18/171643 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/145 (20130101) A61M 5/204 (20130101) A61M 5/14224 (20130101) A61M 5/14276 (20130101) Original (OR) Class A61M 5/14593 (20130101) A61M 39/06 (20130101) A61M 2039/0072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201514 | Zapol et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Warren M. Zapol (Cambridge, Massachusetts); Lorenzo Berra (Cambridge, Massachusetts); Caio Morais (Quincy, Massachusetts); Stefano Gianni (Boston, Massachusetts); Ryan W. Carroll (Boston, Massachusetts); Walfre Franco (Westborough, Massachusetts); Binglan Yu (Lexington, Massachusetts); R. Rox Anderson (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for generating and delivering nitric oxide are provided. In one aspect, a nitric oxide generator includes an inlet arranged to receive a gas including nitrogen and oxygen, an outlet, a pair of electrodes arranged downstream of the inlet and configured to generate nitric oxide from the gas, a pressure regulator configured to selectively adjust a pressure of the gas surrounding the electrodes, an accumulator in communication with the pressure regulator, a nitric oxide sensor arranged to measure a concentration of nitric oxide at the outlet, and a controller in communication with the pair of electrodes, the pressure regulator, and the nitric oxide sensor. The controller is configured to selectively instruct the pressure regulator to adjust the pressure of the gas surrounding the electrodes in response to the concentration of nitric oxide measured at the outlet by the nitric oxide sensor. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 18/008316 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/12 (20130101) Original (OR) Class A61M 16/105 (20130101) A61M 16/208 (20130101) A61M 16/1005 (20140204) A61M 2016/102 (20130101) A61M 2202/0266 (20130101) A61M 2202/0275 (20130101) A61M 2205/3344 (20130101) A61M 2230/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201833 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Tza-Huei Jeff WANG (Timonium, Maryland); Alexander Y. TRICK (Baltimore, Maryland); Fan-En CHEN (Baltimore, Maryland) |
| ABSTRACT | Provided herein are magnetofluidic cartridges of use in a wide variety of sample analysis applications, including nucleic acid amplification assays. The magnetofluidic cartridges include sample inlet wells and sample analysis wells. Temperature sensitive materials are used to separate the sample inlet wells and sample analysis wells from one another prior to performing a given sample analysis application. Related magnetofluidic devices, kits, and methods are also provided. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/999677 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/16 (20130101) B01L 2200/0647 (20130101) B01L 2200/0684 (20130101) B01L 2200/0689 (20130101) B01L 2300/087 (20130101) B01L 2300/0816 (20130101) B01L 2300/0874 (20130101) B01L 2300/1805 (20130101) B01L 2400/043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/0098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202983 | Kunos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | George Kunos (Bethesda, Maryland); Malliga Iyer (Germantown, Maryland); Resat Cinar (Bethesda, Maryland); Kenner C. Rice (Bethesda, Maryland) |
| ABSTRACT | A compound, or a pharmaceutically acceptable salt or ester thereof, comprising (i) a CB1 receptor mediating scaffold conjugated to (ii) a second therapeutic scaffold. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956313 |
| CURRENT CPC | Heterocyclic Compounds C07D 231/06 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 409/12 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202993 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Biohaven Pharmaceutical Holding Company Ltd. (New Haven, Connecticut); Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Garry Robert Smith (Royersford, Pennsylvania); Allen B. Reitz (Lansdale, Pennsylvania); Mark McDonnell (Lansdale, Pennsylvania); Suzie Chen (Highland Park, New Jersey); Matthew D. Vera (Collegeville, Pennsylvania); Benjamin E. Blass (Eagleville, Pennsylvania); Jeffrey Claude Pelletier (Lafayette Hill, Pennsylvania); Venkata N. Velvadapu (Philadelphia, Pennsylvania); Jay Edward Wrobel (Lawrenceville, New Jersey) |
| ABSTRACT | Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940287 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/428 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 277/82 (20130101) Original (OR) Class C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203002 | Speerschneider et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trevena, Inc. (Chesterbrook, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aimee Crombie Speerschneider (Chesterbrook, Pennsylvania); Dennis Shinji Yamashita (Chesterbrook, Pennsylvania); Philip Michael Pitis (Chesterbrook, Pennsylvania); Michael John Hawkins (Chesterbrook, Pennsylvania); Guodong Liu (Chesterbrook, Pennsylvania); Tamara Ann Miskowski Daubert (Chesterbrook, Pennsylvania); Catherine C.K. Yuan (Chesterbrook, Pennsylvania); Robert Borbo Kargbo (Chesterbrook, Pennsylvania); Robert Jason Herr (Chesterbrook, Pennsylvania); Donna Romero (Chesterbrook, Pennsylvania); Gregory J. Pacofsky (Chesterbrook, Pennsylvania) |
| ABSTRACT | The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/879923 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/445 (20130101) Heterocyclic Compounds C07D 211/22 (20130101) C07D 241/04 (20130101) C07D 401/12 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 405/14 (20130101) C07D 451/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203020 | Brabander et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jef De Brabander (Dallas, Texas); Qiren Liang (Dallas, Texas); Beth Levine (Dallas, Texas); Wei-Chung Chiang (Dallas, Texas) |
| ABSTRACT | Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity. |
| FILED | Saturday, February 11, 2023 |
| APPL NO | 18/167835 |
| CURRENT CPC | Heterocyclic Compounds C07D 231/06 (20130101) C07D 231/12 (20130101) C07D 401/04 (20130101) C07D 403/04 (20130101) C07D 405/04 (20130101) Original (OR) Class C07D 405/06 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 409/04 (20130101) C07D 413/04 (20130101) C07D 413/10 (20130101) C07D 417/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203025 | Burnett, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota); Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Burnett, Jr. (Rochester, Minnesota); Jeson Sangaralingham (Rochester, Minnesota); Siobhan Malany (Orlando, Florida); Satyamaheshwar Peddibhotla (Orlando, Florida); Paul Mitchell Hershberger (Satellite Beach, Florida); Patrick Maloney (Orlando, Florida); Edward Hampton Sessions, Jr. (Orlando, Florida) |
| ABSTRACT | In some embodiments, the present disclosure provides a compound of Formula (I), as described herein, or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising the compound of Formula (I), and methods of treating, e.g., metabolic diseases using the compound of Formula (I) are also provided. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/928468 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) Heterocyclic Compounds C07D 417/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203030 | Crew et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arvinas Operations, Inc. (New Haven, Connecticut); Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew P. Crew (Guilford, Connecticut); Craig M. Crews (New Haven, Connecticut); Xin Chen (Trumbull, Connecticut); Hanqing Dong (Madison, Connecticut); Caterina Ferraro (Stamford, Connecticut); Yimin Qian (Plainsboro, New Jersey); Kam Siu (Milford, Connecticut); Jing Wang (Milford, Connecticut); Meizhong Jin (East Northport, New York); Michael Berlin (Flemington, New Jersey); Kurt Zimmermann (Durham, Connecticut); Lawrence Snyder (Killingworth, Connecticut) |
| ABSTRACT | The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/931814 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/06 (20130101) C07D 403/14 (20130101) C07D 405/14 (20130101) C07D 413/14 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) C07D 471/04 (20130101) Original (OR) Class C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203082 | Gelb et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| INVENTOR(S) | Michael H. Gelb (Seattle, Washington); Arun Babu Kumar (Seattle, Washington); Frances Hocutt (Seattle, Washington); Zdenek Spacil (Seattle, Washington); Mariana Natali Barcenas Rodriguez (Seattle, Washington); Frantisek Turecek (Seattle, Washington); C. Ronald Scott (Seattle, Washington) |
| ABSTRACT | Reagents, methods, and kits for assaying enzymes associated with lysosomal storage diseases MPS-I, MPS-II, MPS-IIIA, MPS-IIIB, MPS-IVA, MPS-VI, and MPS VII. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/112871 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/203 (20130101) Original (OR) Class C07H 19/01 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/924 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203084 | Fang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Shiyue Fang (Houghotn, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shiyue Fang (Houghotn, Michigan) |
| ABSTRACT | Embodiments for the synthesis of sensitive oligonucleotides as well as insensitive oligonucleotides are provided. Sulfur-based groups are used for the protection of exo-amino groups of nucleobases, phosphate groups and 2′-OH groups, and as cleavable linker for linking oligonucleotides to a support. Oligonucleotide syntheses are achieved under typical conditions using phosphoramidite chemistry with important modifications. To prevent replacing sulfur-based protecting groups by acyl groups via cap-exchange, special capping agents are used. To retain hydrophobic tag to assist RP HPLC purification, special phosphoramidites are used in the last synthetic cycle. With the sulfur-based groups for protection and linking, oligonucleotide deprotection and cleavage are achieved via oxidation followed by beta-elimination under mild conditions. Therefore, besides for insensitive oligonucleotide synthesis, the embodiments of the invention are capable for the synthesis of oligonucleotide analogs containing sensitive functional groups that cannot survive the harsh conditions used in prior art oligonucleotide synthesis technologies. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 17/978214 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/10 (20130101) C07H 19/20 (20130101) Original (OR) Class C07H 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203096 | PELLECCHIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| INVENTOR(S) | Maurizio PELLECCHIA (San Diego, California); Carlo BAGGIO (Moreno Valley, California); Iryna ETHELL (Riverside, California); Anna KULINICH (Riverside, California); Kathrin Christine MEYER (Columbus, Ohio); Cassandra Nicole DENNYS-RIVERS (Westerville, Ohio) |
| ABSTRACT | Certain embodiments of the invention provide EphA4 targeting compounds and compositions comprising a compound described herein. Certain embodiments of the invention also provide methods of treating a neurological disease (e.g., Amyotrophic Lateral Sclerosis, Alzheimer's Disease) or cancer. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/920231 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203101 | HWANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION (Pohang-si, Gyeongsangbuk-do, South Korea); KOREA NATIONAL INSTITUTE OF HEALTH (Cheongju-si, Chungcheongbuk-do, South Korea); BIOAPPLICATIONS INC (Pohang-si, Gyeongsangbuk-do, South Korea) |
| ASSIGNEE(S) | POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION (Pohang-si, Gyeongsangbuk-do, South Korea); KOREA NATIONAL INSTITUTE OF HEALTH (Cheongju-si, Chungcheongbuk-do, South Korea); BIOAPPLICATIONS INC (Pohang-si, Gyeongsangbuk-do, South Korea) |
| INVENTOR(S) | In Hwan HWANG (Pohang-si, Gyeongsangbuk-do, South Korea); Shijian SONG (Pohang-si, Gyeongsangbuk-do, South Korea); Rezaul Islam Khan MD (Pohang-si, Gyeongsangbuk-do, South Korea); Haiping DIAO (Pohang-si, Gyeongsangbuk-do, South Korea); Eun Ju SOHN (Pohang-si, Gyeongsangbuk-do, South Korea); Bo Hwa CHOI (Pohang-si, Gyeongsangbuk-do, South Korea); Jang Hoon CHOI (Cheongju-si, Chungcheongbuk-do, South Korea); Eun Young JANG (Cheongju-si, Chungcheongbuk-do, South Korea); Young Jae LEE (Cheongju-si, Chungcheongbuk-do, South Korea) |
| ABSTRACT | The present invention relates to a recombinant spike protein of the COVID-19 virus forming a trimer and a method for mass-producing the recombinant spike protein, and more specifically to a method for designing a recombinant gene expressing a recombinant spike protein of the COVID-19 virus forming a trimer for the purposes of enhancing immunogenicity and effective antigen delivery, and a method for mass-producing the recombinant spike protein in plants. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/920526 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8258 (20130101) C12N 2511/00 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) C12N 2770/20043 (20130101) C12N 2770/20051 (20130101) C12N 2770/20071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203104 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tzyy-Choou Wu (Stevenson, Maryland); Chien-Fu Hung (Timonium, Maryland); Tae Heung Kang (, None) |
| ABSTRACT | The present invention provides synthetic polypeptides comprising an annexin V protein, or a functional portion or fragment or variant thereof, conjugated to a tumor antigen, or a functional portion or fragment or variant thereof. The invention further provides methods for making said synthetic polypeptides and their use in the treatment of proliferative diseases such as cancer and tumors originating therefrom. |
| FILED | Friday, August 02, 2019 |
| APPL NO | 17/265498 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/005 (20130101) C07K 14/025 (20130101) Original (OR) Class C07K 14/4705 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203110 | St-Pierre et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | François St-Pierre (Houston, Texas); Jihwan Lee (Houston, Texas); Zhuohe Liu (Houston, Texas) |
| ABSTRACT | Provided herein are photostable fluorescent proteins and methods of making and using those proteins. A photostable fluorescent protein variant is provided comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:3, wherein the amino acid sequence comprises a first substitution at a residue corresponding to residue 46 of a polypeptide of SEQ ID NO:2 and a second substitution at a residue corresponding to residue 63 of the polypeptide of SEQ ID NO:2, and the variant is more photostable than the polypeptide of SEQ ID NO:2. A method of detecting a protein of interest is also provided, comprising the steps of expressing a fusion protein and detecting the fluorescence of the fusion protein, thereby detecting the protein of interest. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/759323 |
| CURRENT CPC | Peptides C07K 14/43595 (20130101) Original (OR) Class C07K 2319/60 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203123 | WONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (BOSTON, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (BOSTON, Massachusetts) |
| INVENTOR(S) | Wilson W. WONG (Brookline, Massachusetts); Jang Hwan CHO (Chestnut Hill, Massachusetts) |
| ABSTRACT | Described herein is a chimeric antigen receptor (CAR) platform with the ability to (a) serve as an ON/OFF switch (with the ability for tenability/titrability), (b) sense multiple antigens and perform logic computations, and/or (c) independently regulate multiple signaling pathways. The compositions provided herein permit the degree of control and discrimination necessary to optimize CAR T cell therapy. Also described herein are cells comprising such compositions and the use of these compositions and/or cells in the treatment of cancer. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 18/053432 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 2039/5156 (20130101) Peptides C07K 14/315 (20130101) C07K 14/4738 (20130101) C07K 14/7051 (20130101) Original (OR) Class C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/00 (20130101) C07K 16/18 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/32 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/70 (20130101) C07K 2319/73 (20130101) C07K 2319/80 (20130101) C07K 2319/81 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203124 | Tran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, a represented by the Secretary, Department of Health and Human Servi (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, a represented by the Secretary, Department of Health and Human Servi (Bethesda, Maryland) |
| INVENTOR(S) | Eric Tran (Portland, Oregon); Yong-Chen Lu (Little Rock, Arkansas); Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed are methods of isolating a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous APCs of the patient to present the mutated amino acid sequence; co-culturing autologous T cells of the patient with the autologous APCs that present the mutated amino acid sequence; selecting the autologous T cells; and isolating a nucleotide sequence that encodes the TCR from the selected autologous T cells, wherein the TCR has antigenic specificity for the mutated amino acid sequence encoded by the cancer-specific mutation. Also disclosed are related methods of preparing a population of cells, populations of cells, TCRs, pharmaceutical compositions, and methods of treating or preventing cancer. |
| FILED | Thursday, December 29, 2022 |
| APPL NO | 18/147786 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Peptides C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) C12N 2501/505 (20130101) C12N 2501/998 (20130101) C12N 2502/99 (20130101) C12N 2510/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6866 (20130101) G01N 33/6869 (20130101) G01N 33/56977 (20130101) G01N 2333/54 (20130101) G01N 2333/55 (20130101) G01N 2333/57 (20130101) G01N 2333/525 (20130101) G01N 2333/535 (20130101) G01N 2333/4725 (20130101) G01N 2333/5406 (20130101) G01N 2333/5409 (20130101) G01N 2333/5425 (20130101) G01N 2333/5428 (20130101) G01N 2333/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203157 | Torchia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Torchia (Boston, Massachusetts); Gordon J. Freeman (Brookline, Massachusetts) |
| ABSTRACT | The present invention relates, in part, to methods for inhibiting activation of T cells in a cell-specific and/or tissue-specific manner, and to bispecific molecules comprising a first part that specifically binds to PD-1 and a second part that specifically binds to a surface antigen of a target cell other than a T cell. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/927529 |
| CURRENT CPC | Peptides C07K 16/30 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/52 (20130101) C07K 2317/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203163 | Gil-Pages et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Diana Gil-Pages (Columbia, Missouri); Adam G. Schrum (Columbia, Missouri) |
| ABSTRACT | The present disclosure is generally directed to compositions and methods for treating viral infections. In particular, pharmaceutical compositions of the present disclosure include a monovalent anti-CD3 antibody and a viral antigen and their use as adjuvants to treat a viral infection and to increase the immune response produced against a viral antigen. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 18/050845 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Peptides C07K 16/2809 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203187 | Simons et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Simons (New Haven, Connecticut); Federico Corti (New Haven, Connecticut) |
| ABSTRACT | Provided are anti-syndecan-2 antibodies and compositions comprising said antibody and methods useful for treating acute respiratory distress syndrome, including coronavirus disease 2019-induced acute respiratory distress syndrome, in a subject in need thereof. The method comprises administering to the subject an effective amount to treat the acute respiratory distress syndrome of an syndecan-2 disrupting agent. The syndecan-2 disrupting agents may include at least one of the anti-syndecan-2 antibodies and/or at least one syndecan-2 disrupting peptide. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/999639 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) A61K 38/1709 (20130101) A61K 39/00 (20130101) Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203447 | Cho |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hee Cheol Cho (Johns Creek, Georgia) |
| ABSTRACT | This disclosure relates to method of differentiating stem cells to specific cardiac-like cells. In certain embodiments, the disclosure contemplates methods of generating left ventricular-like cells and the atrial-like cells by timing the exposure of dividing stem cells to retinoic acid (RA) or retinoic acid receptor inhibitors. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/115283 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0657 (20130101) Original (OR) Class C12N 2501/16 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2501/415 (20130101) C12N 2506/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203462 | Yuan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Zhedfan Yuan (Seattle, Washington); Shaoyi Jiang (Seattle, Washington); Yanjiao Han (Seattle, Washington); Sijin Luozhong (Seattle, Washington) |
| ABSTRACT | Provided are compositions and methods for the production of modified endonucleases such as CRISPR/Cas9 system with reduced off-target activity. Methods of editing of polynucleotides using the modified endonucleases in vitro and in vivo are also disclosed. In one aspect, the disclosure provides a modified endonuclease, comprising an endonuclease and one or more mixed charge moieties covalently linked to the endonuclease, wherein each mixed charge moiety comprises about 10 to about 400 positively charged moieties and about 10 to about 400 negatively charged moieties, and wherein the ratio of the number of positively charged moieties to the number of negatively charged moieties is from about 1 :0.5 to about 1 :2. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/767426 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203482 | PUCHALT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (Philadelphia, Pennsylvania); University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfredo Perales PUCHALT (Philadelphia, Pennsylvania); John LUECK (Rochester, New York); Christopher A. AHERN (Iowa City, Iowa); David B. WEINER (Merion, Pennsylvania) |
| ABSTRACT | The present invention provides compositions and methods for treating diseases and disorders associated with premature termination codons comprising administration of nucleic acid molecules comprising or encoding anticodon edited tRNAs. |
| FILED | Friday, November 02, 2018 |
| APPL NO | 16/760932 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203485 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Patrick C. Lee (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Catherine Wu (Brookline, Massachusetts); James A. Decaprio (Wellesley, Massachusetts); Derin B. Keskin (Newton, Massachusetts); Patrick C. Lee (Boston, Massachusetts); Sara Buhrlage (Somerville, Massachusetts) |
| ABSTRACT | The present invention relates, in part, to compositions and methods for modulating major histocompatibility complex (MHC) I expression on cancer cells. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/928444 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) C07K 2317/24 (20130101) C07K 2317/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/531 (20130101) Enzymes C12Y 304/19012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203487 | Marbán et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eduardo Marbán (Santa Monica, California); Alessandra Ciullo (Los Angeles, California); Ahmed G. Ibrahim (Los Angeles, California) |
| ABSTRACT | Provided herein are PIWI-interacting RNA (piRNA) derived from therapeutic exosomes, and methods of use thereof to treat a condition requiring tissue repair and/or regeneration. Conditions treated by the exosome-derived piRNAs and/or exosomes carrying the same include, in some embodiments, ischemic injury and/or tissue fibrosis. Also provided are therapeutic compositions comprising exosome-derived piRNA and a pharmaceutically acceptable excipient. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/998857 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 35/28 (20130101) A61K 35/33 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 11/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2320/32 (20130101) C12N 2320/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203492 | Moulton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon); The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon); The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Hong M. Moulton (Corvallis, Oregon); David Adam Stein (Corvallis, Oregon); Heinrich Ulrich Feldmann (Hamilton, Montana); Kyle Ture Rosenke (Hamilton, Montana) |
| ABSTRACT | Disclosed herein are embodiments of a compound useful for treating or preventing betacoronavirus infections such as SARS-Cov-2 infections. Also disclosed is a method for administering the compound to a subject, particularly a human subject, to treat or prevent a betacoronavirus infection in the subject. The compound can comprise an oligomer comprising a nucleic acid base sequence that is antisense to at least a portion of a SARS-CoV-2 genomic RNA, and can comprise a sequence present in the 5′ UTR and first 20 nt of coding sequence of the SARS-CoV-2 genomic RNA. The compound also can contain a peptide sequence. In some embodiments, the compound is a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO). |
| FILED | Monday, November 07, 2022 |
| APPL NO | 18/053308 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 47/64 (20170801) A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1131 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/321 (20130101) C12N 2310/3125 (20130101) C12N 2310/3231 (20130101) C12N 2310/3233 (20130101) C12N 2310/3513 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203499 | Manfredsson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dignity Health (San Francisco, California); Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fredric Manfredsson (San Francisco, California); Kathy Steece-Collier (East Lansing, Michigan) |
| ABSTRACT | Disclosed are systems and compositions for reducing the expression of a CaV1.3 protein in a subject and methods of using the systems for treating dyskinesias induced by DA agonist therapy including levodopa-induced dyskinesias (LID), improving the response to levodopa, and improving the response to levodopa in a subject in need thereof; and slowing progression of Parkinson's disease by providing protection against death or dysfunction of substantia nigra dopamine neurons. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/998128 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203508 | Asokan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chape Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravind Asokan (Chapel Hill, North Carolina); Erin Borchardt (Naperville, Illinois); Rita Meganck (Raleigh, North Carolina); William F. Marzluff (Hillsborough, North Carolina) |
| ABSTRACT | This invention is directed to AAV compositions for circular RNA expression and methods of expressing covalently closed, circular RNA. |
| FILED | Wednesday, November 07, 2018 |
| APPL NO | 16/761876 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203533 | Zolotukhin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Sergei Zolotukhin (Gainesville, Florida); Oleksandr Kondratov (Gainesville, Florida) |
| ABSTRACT | Provided herein are methods and compositions useful in the screening and production of recombinant AAV (rAAV) that have structural fitness and potency in insect cells and mammalian cells. The disclosure provides a directed evolution system for generating and selecting rAAV variants based on their Kozak sequences. In some embodiments, methods disclosed herein comprise the use of modified Kozak sequences to express AAV2 VP1 proteins in amounts that are useful for producing rAAV particles having high infectivities and/or transduction efficiencies. In some embodiments, methods of producing, and methods of screening, rAAV are provided that comprise the steps of infecting insect cells by administering rAAV to these cells, recovering rAAV-integrated DNA from these insect cells, and transfecting recovered rAAV into mammalian cells. Also provided herein are nucleic acids comprising nucleotide sequences encoding novel Kozak sequences. Further provided herein are mammalian cells, baculovirus particles and insect cells comprising these nucleic acids. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/922174 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2710/14143 (20130101) C12N 2750/14143 (20130101) C12N 2750/14151 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 10/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203538 | Parhiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hamideh Parhiz (Philadelphia, Pennsylvania); Drew Weissman (Philadelphia, Pennsylvania); Jonathan Epstein (Radnor, Pennsylvania); Istvan Tombacz (Philadelphia, Pennsylvania); Joel Rurik (Philadelphia, Pennsylvania); Haig Aghajanian (Lafayette Hill, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods for T cell targeted delivery of nucleoside modified mRNA molecules encoding agents for the treatment and prevention of fibrosis, cardiac disease, and diseases and disorders associated therewith. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938816 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/51 (20130101) A61K 9/127 (20130101) A61K 47/6929 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203551 | Smolke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christina D. Smolke (Stanford, California); Yanran Li (Stanford, California) |
| ABSTRACT | Engineered non-plant cells that produce a benzylisoquinoline alkaloid product that is a derivative of canadine along a metabolic pathway that converts canadine, or an analog of canadine, to a noscapinoid product are provided. Methods of culturing engineered non-plant cells that produce a noscapinoid product and pharmaceutical compositions are also provided. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/070633 |
| CURRENT CPC | Heterocyclic Compounds C07D 273/01 (20130101) C07D 515/02 (20130101) C07D 515/14 (20130101) C07D 515/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/02 (20130101) C12N 1/14 (20130101) C12N 9/1003 (20130101) C12N 2330/50 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/16 (20130101) C12P 17/188 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203562 | OKERBERG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Encodia, Inc. (San Diego, California) |
| ASSIGNEE(S) | Encodia, Inc. (San Diego, California) |
| INVENTOR(S) | Eric OKERBERG (San Diego, California); Kevin L. GUNDERSON (Encinitas, California); Norihito MURANAKA (San Diego, California); Jongbum KIM (San Diego, California); Byung Joon LIM (Seoul, South Korea); Lei SHI (San Diego, California); Soumya GANGULY (San Diego, California); Devin SULLIVAN (San Diego, California) |
| ABSTRACT | Provided herein are high-throughput, population-wide serotyping and antibody profiling assays. Disclosed variants of a Digital Serotyping assay employ next generation sequencing to measure the “serotyping profile” of barcoded subject serum antibodies tested against a range of DNA-tagged pathogen-derived antigens. The disclosed assay setup enables multiplexing in both the sample and antigen dimensions, generating a large multi-dimensional serotyping data set for more comprehensive serotyping profiling of large populations across a large number of antigens and possible pathogens. Moreover, the ability to easily scale and multiplex the number of peptide epitopes allows rapid updating of the assay content to monitor the ever-changing spectrum of pathogens. Additional applications of this technology include cancer immunology and autoimmune conditions (e.g., neoantigen or autoimmune profiling), screening for toxins, antibody therapeutics development, biosecurity, and veterinary medicine. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089444 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2458/10 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203563 | Xie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoliang Sunney Xie (Lexington, Massachusetts); Dong Xing (Cambridge, Massachusetts); Chi-Han Chang (Cambridge, Massachusetts); Longzhi Tan (Somerville, Massachusetts) |
| ABSTRACT | The present disclosure provides a method for assembly of genomic DNA using multiplex end-tagging amplification of genomic fragments. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 18/055024 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6874 (20130101) C12Q 2521/101 (20130101) C12Q 2521/507 (20130101) C12Q 2525/155 (20130101) C12Q 2535/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203566 | SIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); Rover Diagnostics, Inc. (Greenvale, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York); Rover Diagnostics, Inc. (Greenvale, New York) |
| INVENTOR(S) | Samuel K. SIA (New York, New York); Nicole R. BLUMENFELD (New York, New York); Mark FASCIANO (Port Washington, New York); Bulent ONALIR (Englewood, New Jersey); Martin JASPAN (Somerville, Massachusetts) |
| ABSTRACT | Methods and apparatus for rapid and accurate detection of nucleic acid in a single reaction chamber are provided. In one aspect, a patient specimen suspected of comprising a first nucleic acid is used to form a crude lysate which is combined with an infrared absorbing material, a detecting nucleic acid, and at least one reporter molecule in the single reaction chamber and heated by irradiating the reaction mixture with infrared light. Another aspect is directed to an apparatus for detecting a presence or absence of a plurality of different molecules within a reaction container. The apparatus comprises an infrared light source aimed to illuminate contents of the reaction container; an excitation light source positioned to illuminate contents of the reaction container; and a spectrometer positioned to detect emission light emanating from the reaction container. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/986121 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6816 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203567 | KIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Youngeun KIM (Cambridge, Massachusetts); Jocelyn Yoshiko KISHI (Cambridge, Massachusetts); Thomas E. SCHAUS (Cambridge, Massachusetts); Adam YASEEN (Cambridge, Massachusetts); Peng YIN (Cambridge, Massachusetts); Sinem K. SAKA (Cambridge, Massachusetts); Kuanwei SHENG (Cambridge, Massachusetts); Nikhil GOPALKRISHNAN (Cambridge, Massachusetts); Jiyoun JEONG (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to methods, kits, compositions, devices, and systems for detecting a target nucleic acid, such as a viral RNA. In one aspect, described herein are methods of detecting the target nucleic acid. In other aspects, described herein are compositions, kits, devices, and systems suitable to practice the methods described herein to detect the target nucleic acid. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/996846 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Original (OR) Class C12Q 1/6853 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203568 | Adalsteinsson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Viktor A. Adalsteinsson (Cambridge, Massachusetts); Gregory Gydush (Cambridge, Massachusetts); Gerassimos Makrigiorgos (Boston, Massachusetts); Erica Nguyen (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure provides novel methods, compositions, and kits that combine hybrid capture using short allele-specific probes with duplex molecular” barcoding and noise modeling within each sample to afford high accuracy sequencing of rare mutations at low cost. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/792638 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/683 (20130101) Original (OR) Class C12Q 1/686 (20130101) C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203569 | Kanavarioti |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Anastassia Kanavarioti (El Dorado Hills, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastassia Kanavarioti (El Dorado Hills, California) |
| ABSTRACT | Provided for herein is a method for detecting the presence of a nucleic acid target molecule in a biological sample. In certain aspects, the method comprises contacting a test sample that comprises (i) a biological sample comprising a nucleic acid target molecule and (ii) an osmylated single-stranded oligonucleotide probe comprising at least one pyrimidine residue covalently bonded to a substituted or unsubstituted Osmium tetroxide (OsO4)-2,2′-bypyridine group (OsBp group). |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/897743 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6832 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203584 | Pirruccello et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | James P. Pirruccello (Boston, Massachusetts); Patrick T. Ellinor (Boston, Massachusetts) |
| ABSTRACT | The disclosure provides methods of assessing a subject's risk of ascending thoracic aortic aneurysm or descending thoracic aortic aneurysm by detecting one or more single nucleotide polymorphisms (SNP) in one or more specific genes. The disclosure also provides methods of calculating a polygenic score to assess a subjects risk. Such methods may be used, for example, to identify asymptomatic subjects at risk for aneurysm. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/923845 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203585 | Plante et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | David Thomas Plante (Madison, Wisconsin); Reid Spencer Alisch (Prairie du Sac, Wisconsin) |
| ABSTRACT | Differentially methylated positions associated with hypersomnolence, idiopathic hypersomnia, and long sleep time are provided herein along with biomarker panels thereof and methods of diagnosing and providing a prognosis of hypersomnolence, idiopathic hypersomnia, and long sleep time using said differentially methylated positions. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/926804 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203587 | SKOG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Exosome Diagnostics, Inc. (Waltham, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Johan SKOG (Lincoln, Massachusetts); Vasisht TADIGOTLA (Newton, Massachusetts); James HURLEY (Marblehead, Massachusetts); Jamil AZZI (Boston, Massachusetts) |
| ABSTRACT | The present disclosure relates to methods of identifying and treating kidney rejection in a subject comprising analyzing microvesicular RNA, cell-free DNA or the combination of microvesicular and cell-free DNA.” |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/928452 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203588 | Darnell et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE ROCKEFELLER UNIVERSITY (New York, New York); The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert B. Darnell (New York, New York); Dana Orange (New York, New York); Olga G. Troyanskaya (Princeton, New Jersey); Vicky Yao (Houston, Texas) |
| ABSTRACT | The present invention provides biological markers which are molecular and cellular antecedents of rheumatoid arthritis (RA) flares. The invention provides RNA and protein markers that can predict an RA flare one or two weeks prior to the flare. The invention further provides blood circulating cells, particularly pre-inflammatory mesenchymal cells, which are cellular precursors and indicators of an impending RA flare. The present invention further provides methods, kits and markers for identification and monitoring of flares in RA patients and their application as markers and targets in and for treatment of rheumatoid arthritis and conditions induced or related to rheumatoid arthritis. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/928513 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203597 | Kurtz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Carlos, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 18/056652 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 35/20 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203602 | FOXMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ellen FOXMAN (West Hartford, Connecticut); Marie LANDRY (Guilford, Connecticut) |
| ABSTRACT | The present disclosure concerns methods of detecting viral respiratory infections by analyzing biomarkers in a viral transport medium sample. In various embodiments the biomarkers are assessed by measuring mRNA or protein. In certain embodiments the biomarkers are nasal-virus induced molecules. |
| FILED | Wednesday, October 11, 2017 |
| APPL NO | 16/340328 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/7158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204565 | Bhaduri et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aparna Bhaduri (San Francisco, California); Elizabeth Di Lullo (San Francisco, California); Arnold R. Kriegstein (Mill Valley, California) |
| ABSTRACT | The present disclosure provides a brain organoid for culturing cancer cells for a prolonged period of time and methods for culturing cancer cells in a brain organoid for a period of time at least one week. The cancer cells may be primary cancer cells obtained from a cancer from a subject. The brain organoid may be generated from embryonic stem cells or induced pluripotent stem cells that are not transformed to render them oncogenic. In certain aspects, the cancer cells cultured in the brain organoid may be Protein Tyrosine Phosphatase Receptor Type Z1 (PTPRZ1) expressing cancer cells obtained from a cancer from a subject. Also provided are methods for inhibiting tumor invasion in a cancer of a nervous system by administering to a subject suffering from such cancer an inhibitor of the PTPRZ1 pathway and for screening for inhibitors of cancer cell growth and/or invasion. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/785818 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) C12N 5/0693 (20130101) C12N 2501/15 (20130101) C12N 2501/415 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204577 | Darrah et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erika L. Darrah (Baltimore, Maryland); Felipe Andrade (Timonium, Maryland) |
| ABSTRACT | A method for measuring anti-PAD2 antibodies in a subject with an inflammatory or autoimmune disease, and to determine if the subject has a better prognosis for developing a more severe form of inflammation based on anti-PAD2 antibody levels. Methods for the therapeutic use of anti-PAD2 antibodies are also described. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/111179 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0008 (20130101) A61K 39/39533 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) A61P 29/00 (20180101) A61P 37/06 (20180101) Peptides C07K 16/40 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) Enzymes C12Y 305/03015 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 2333/978 (20130101) G01N 2800/24 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/7095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204579 | Ley |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | La Jolla Institute for Immunology (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Klaus Ley (La Jolla, California) |
| ABSTRACT | The present invention includes methods to determine a risk of a cardiovascular disease (CVD) or a subclinical CVD (sCVD) in a subject, by detecting a subset of intermediate monocyte cell populations in the immune cells, wherein a percentage of the subsets as compared to a total intermediate monocyte cell population present in the isolated immune cells is determined; comparing a proportion of the subsets subset of intermediate monocyte cell populations determined with a statistical sample representative of a proportion of equivalent subsets in a total intermediate monocyte cell populations from a subject that does not have a cardiovascular disease; and determining that the subject has an increased risk for cardiovascular disease where the subject has a decrease in the certain subsets, has an increase in another subset, or both, as compared to the statistical sample. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/923325 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 33/56972 (20130101) Original (OR) Class G01N 2333/705 (20130101) G01N 2800/32 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204583 | Shroyer et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Kenneth R. Shroyer (Setauket, New York); Luisa F. Escobar-Hoyos (Calverton, New York); Emily I. Chen (Stony Brook, New York) |
| ABSTRACT | The current disclosure provides methods for detecting and analyzing KRT4 and KRT17 expression in a sample obtained from a test subject. The current disclosure pertains to methods and kits for identifying a mammalian subject with cervical cancer or non-cancerous lesions of the cervix. The current disclosure further provides methods and kits for determining the likelihood of survival or treatment outcome of a subject having cervical cancer by determining the expression level of KRT17 in a sample. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 18/057949 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57411 (20130101) Original (OR) Class G01N 2333/4742 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230206413 | McCall et al. |
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| FUNDED BY |
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| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian McCall (Dallas, Texas); Wensheng Fan (Plano, Texas); Jason Dwight (Dallas, Texas); Zhicun Gao (Plano, Texas); Jeffrey E. Thatcher (Irving, Texas); John Michael DiMaio (Dallas, Texas) |
| ABSTRACT | Generally described, one or more aspects of the present application correspond to systems and techniques for spectral imaging using a multi-aperture system with curved multi-bandpass filters positioned over each aperture. The present disclosure further relates to techniques for implementing spectral unmixing and image registration to generate a spectral datacube using image information received from such imaging systems. Aspects of the present disclosure relate to using such a datacube to analyze the imaged object, for example to analyze tissue in a clinical setting, perform biometric recognition, or perform materials analysis. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/178875 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 7/33 (20170101) G06T 7/55 (20170101) G06T 7/62 (20170101) G06T 2207/10036 (20130101) G06T 2207/10144 (20130101) G06T 2207/20221 (20130101) Pictorial Communication, e.g Television H04N 5/265 (20130101) H04N 23/55 (20230101) H04N 23/56 (20230101) H04N 23/743 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230201066 | Asbeck et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Alan Thomas Asbeck (Cambridge, Massachusetts); Ye Ding (Cambridge, Massachusetts); Ignacio Galiana Bujanda (Cambridge, Massachusetts); Sangjun Lee (Cambridge, Massachusetts); Diana Wagner (Cambridge, Massachusetts); Conor J. Walsh (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for providing assistance with human motion, including hip and ankle motion, are disclosed. Sensor feedback is used to determine an appropriate profile for actuating a wearable robotic system to deliver desired joint motion assistance. Variations in user kinetics and kinematics, as well as construction, materials, and fit of the wearable robotic system, are considered in order to provide assistance tailored to the user and current activity. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880570 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/01 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0262 (20130101) A61H 1/0266 (20130101) A61H 3/00 (20130101) Original (OR) Class A61H 2003/007 (20130101) A61H 2201/165 (20130101) A61H 2201/501 (20130101) A61H 2201/503 (20130101) A61H 2201/1659 (20130101) A61H 2201/1695 (20130101) A61H 2201/5038 (20130101) A61H 2201/5061 (20130101) A61H 2201/5069 (20130101) A61H 2201/5071 (20130101) A61H 2201/5079 (20130101) A61H 2201/5084 (20130101) A61H 2201/5097 (20130101) A61H 2205/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201146 | IWAMOTO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Masahiro IWAMOTO (Villanova, Pennsylvania); Maurizio PACIFICI (Philadelphia, Pennsylvania) |
| ABSTRACT | The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RARγ agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/881207 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/185 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/415 (20130101) A61K 35/12 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201254 | Ehrlich et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barbara Ehrlich (New Haven, Connecticut); Sara Rockwell (Madison, Connecticut); Jennifer Benbow (Fort Mill, South Carolina) |
| ABSTRACT | The invention provides a method of treatment comprising reducing therapy-induced adverse effects (TIAE), including chemotherapy-induced adverse effects (CIAE), such as chemotherapy-induced peripheral neuropathy (CIPN) and/or chemotherapy-induced cardiovascular adverse effects (CICAE) in a subject being treated with a CIAE-inducing anti-cancer active ingredient by co-administering to the subject a pharmaceutically effective amount of a NCS-1-protective composition. Related pharmaceutical compositions, diagnostics and screening techniques are also provided. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/073852 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/20 (20130101) A61K 31/337 (20130101) A61K 31/416 (20130101) A61K 31/437 (20130101) A61K 31/5415 (20130101) A61K 33/00 (20130101) A61K 33/14 (20130101) Original (OR) Class A61K 38/57 (20130101) A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201354 | Demirci et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hakan Demirci (Ann Arbor, Michigan); Nicholas Kotov (Ann Arbor, Michigan); Yichun Wang (Ann Arbor, Michigan) |
| ABSTRACT | Disclosed herein are compositions and methods for injecting compounds into a vitreous body. Carbon nanotubes can be functionalized with a variety of agents, such as therapeutic agents and/or diagnostic agents, which can be injected into a vitreous body for treatment or detection of ocular tumors such as retinoblastoma. The carbon nanotubes can effectively penetrate the ocular tumor, making them effective carriers for the therapeutic and/or diagnostic agents. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/998761 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0092 (20130101) A61K 45/06 (20130101) A61K 47/52 (20170801) Original (OR) Class A61K 47/6929 (20170801) A61K 49/0017 (20130101) A61K 49/0095 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/159 (20170801) C01B 2202/34 (20130101) C01B 2202/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201367 | Barberio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio E. Barberio (Cambridge, Massachusetts); Santiago Correa Echavarria (Allston, Massachusetts); Mariane Bandeira Melo (Stoneham, Massachusetts); Talar Tokatlian (Cambridge, Massachusetts); Erik Christopher Dreaden (Atlanta, Georgia); Paula T. Hammond (Newton, Massachusetts); Darrell J. Irvine (Arlington, Massachusetts) |
| ABSTRACT | Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/892496 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1271 (20130101) A61K 38/208 (20130101) A61K 47/544 (20170801) A61K 47/6911 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201787 | Jensen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Klavs F. Jensen (Lexington, Massachusetts); Timothy F. Jamison (Cambridge, Massachusetts); Allan Stuart Myerson (Cambridge, Massachusetts); Jean-Christophe M. Monbaliu (Esneux, Belgium); Mohsen Behnam (Worcester, Massachusetts); Shin Yee Wong (Singapore, Singapore); Nopphon Weeranoppanant (Muang, Thailand); Eve Marie Revalor (Rognes, France); Torsten Stelzer (Old San Juan, Puerto Rico); Jie Chen (Evanston, Illinois); Andrea Adamo (Cambridge, Massachusetts); David R. Snead (Atlanta, Georgia); Ping Zhang (Somerville, Massachusetts) |
| ABSTRACT | Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/086487 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/14 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/004 (20130101) Original (OR) Class B01J 19/18 (20130101) B01J 19/0093 (20130101) B01J 2219/0002 (20130101) B01J 2219/0004 (20130101) B01J 2219/00011 (20130101) B01J 2219/0081 (20130101) B01J 2219/00795 (20130101) B01J 2219/00799 (20130101) B01J 2219/00806 (20130101) B01J 2219/00813 (20130101) B01J 2219/00817 (20130101) B01J 2219/00822 (20130101) B01J 2219/00831 (20130101) B01J 2219/00833 (20130101) B01J 2219/00835 (20130101) B01J 2219/00871 (20130101) B01J 2219/00873 (20130101) B01J 2219/00889 (20130101) B01J 2219/00907 (20130101) B01J 2219/00909 (20130101) B01J 2219/00918 (20130101) B01J 2219/00986 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201824 | Yager et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Paul Yager (Seattle, Washington); Sujatha Kumar (Seattle, Washington) |
| ABSTRACT | Fluidic device and methods of preparing a fibrous pad comprising dried reagents deposited thereon are described. In an embodiment, the fluidic devices comprise a fibrous pad; and a lyophilized reagent depot configured to support nucleic amplification of a target nucleic acid molecule to produce amplicons when dissolved, wherein the lyophilized reagent depot is disposed on the fibrous pad, the lyophilized reagent depot comprising: a nucleic acid amplification enzyme configured to perform a nucleic acid amplification reaction producing amplicons; and a lyophilization agent. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 18/000163 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/52 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 2300/069 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201927 | Wood et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathaniel Joseph Wood (Columbus, Ohio); David John Hoelzle (Columbus, Ohio) |
| ABSTRACT | Estimation algorithms, methods, and systems are provided that estimate the internal temperatures inside of a part being built using powder bed fusion (PBF). Closed-loop state estimation is applied to the problem of monitoring temperature fields within parts during the PBF build process. A simplified linear time-invariant (LTI) model of PBF thermal physics with the properties of stability, controllability and observability is presented. In some aspects, Model Predictive Control (MPC) may be used as an expanded application of an Ensemble Kalman Filter (EnKF) methods to control the PBF process. MPC is used to forecast the PBF build process behavior N time steps into the future and identifies inputs that drive the temperature of a corresponding node in a mesh of n nodes towards a predetermined target temperature. The inputs are |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054534 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) Original (OR) Class B22F 10/85 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/041 (20130101) G05B 13/048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201972 | Lazarus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan S. Lazarus (Bear, Delaware); Gabriel L. Smith (Ellicott City, Maryland); Adam A. Wilson (Columbia, Maryland) |
| ABSTRACT | A method and apparatus for using a laser to form and release an element of an actuator. The method comprising forming an actuator from sheet stock using a laser, where the actuator is three dimensional; releasing an element of the actuator from the sheet stock using the laser; and moving the released part relative to the sheet stock using laser ablation propulsion. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/114679 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/40 (20130101) Original (OR) Class B23K 2103/50 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202103 | Wilkinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Bryan W. Wilkinson (Pittsburgh, Pennsylvania); Daniel M. Connor (Evans City, Pennsylvania); Cynthia Kutchko (Pittsburgh, Pennsylvania); Eric S. Epstein (Pittsburgh, Pennsylvania); Scott J. Moravek (Mars, Pennsylvania); Brian K. Rearick (Allison Park, Pennsylvania); Brian Chiang (Pittsburgh, Pennsylvania) |
| ABSTRACT | Additive manufacturing compositions and methods may include a resin stabilized pigment. The pigment may be easily combined with at least one component of a co-reactive system, such as a co-reactive prepolymer formulation, via solid mixing without the need for grinding or additional solvents. The prepolymer formulation may be pigmented, printed, and cured under ambient conditions, and one or more pigments may be incorporated into the composition to change the color of the composition during printing and/or to selectively change the color of the printed article among several colors. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 18/000297 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0032 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202651 | Christensen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Kevin Thomas Christensen (Plano, Texas); Sang Gyun Park (Southlake, Texas) |
| ABSTRACT | A flight control computer (FCC) may implement automatic rotor tilt control by gathering or receiving, as inputs, airspeed or a commanded airspeed for the aircraft, acceleration or a commanded acceleration for the aircraft, pitch attitude of the aircraft and pilot pitch bias commands for the aircraft, a rotor tilt angle, and/or the like. The FCC calculates, from the airspeed, the commanded airspeed, the acceleration, the commanded acceleration, the pitch attitude, the pilot pitch bias commands, and/or the like, a commanded rotor tilt angle for the aircraft. From the aircraft rotor tilt angle and the commanded rotor tilt angle, the FCC calculates a rotor tilt angle error for the aircraft, and from the rotor tilt angle error, calculates a rotor tilt rate command for the aircraft. The FCC outputs the resulting rotor tilt rate command to (an) aircraft flight control element actuator(s) to tilt the aircraft rotor. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561195 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 13/18 (20130101) B64C 13/22 (20130101) B64C 29/0033 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202673 | Spritzer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary W. Spritzer (Dulles, Virginia); Vincent J. Sacro (Dulles, Virginia); Timothy P. Duston (Sterling, Virginia) |
| ABSTRACT | A system and method is provided that captures command and control string data during an unmanned vehicle operation. The control string includes user inputs (e.g., mouse inputs, keyboard inputs, etc.) and display outputs (i.e., data displaying to the user via displays). The control string data is captured and stored during the sortie (i.e., a flight) and the control string is preserved (also referred to as impounded) when a mishap occurred during the sortie. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212160 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 45/00 (20130101) Original (OR) Class B64D 2045/0065 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202840 | Flanders et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Twelve Benefit Corporation (Berkeley, California) |
| ASSIGNEE(S) | Twelve Benefit Corporation (Berkeley, California) |
| INVENTOR(S) | Nicholas H. Flanders (San Francisco, California); Kendra P. Kuhl (Oakland, California); Carter S. Haines (Berkeley, California); Luka Stevic (Novi Sad, Serbia); Gregory DiCosola (Redmond, Washington) |
| ABSTRACT | A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 18/052845 |
| CURRENT CPC | Separation B01D 53/326 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/382 (20130101) Original (OR) Class C01B 2203/042 (20130101) C01B 2203/062 (20130101) C01B 2203/0475 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 1/23 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202859 | Dosier et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Biomason Inc. (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ginger K. Dosier (Raleigh, North Carolina); John Michael Dosier (Raleigh, North Carolina); Kent J. Smith (Durham, North Carolina) |
| ABSTRACT | The invention is directed to kits, compositions, tools and methods comprising a cyclic industrial process to form biocement. In particular, the invention is directed to materials and methods for decomposing calcium carbonate into calcium oxide and carbon dioxide at an elevated temperature, reacting calcium oxide with ammonium chloride to form calcium chloride, water, and ammonia gas; and reacting ammonia gas and carbon dioxide at high pressure to form urea and water, which are then utilized to form biocement. This cyclic process can be achieved by combining industrial processes with the resulting product as biocement. The process may involve retention of calcium carbonate currently utilized in the manufacture of Portland Cement. |
| FILED | Wednesday, November 02, 2022 |
| APPL NO | 18/052066 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 11/06 (20130101) Original (OR) Class C01F 11/18 (20130101) C01F 11/24 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 12/00 (20130101) C04B 14/22 (20130101) C04B 14/28 (20130101) C04B 18/12 (20130101) C04B 18/16 (20130101) C04B 22/0026 (20130101) C04B 28/10 (20130101) C04B 2103/0001 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203053 | Chavez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xalud Therapeutics, Inc. (Berkeley, California) |
| ASSIGNEE(S) | Xalud Therapeutics, Inc. (Berkeley, California) |
| INVENTOR(S) | Raymond A. Chavez (Alameda, California); Stephen Collins (Lake Forest, Illinois) |
| ABSTRACT | The present invention encompasses improved morphian compositions and methods of use of the improved compositions for modulating neuropathic pain, opioid-induced glial activation, or a combination thereof beyond what is currently known in the art. The methods involve administering the compound of Formula I to a subject. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/962187 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) A61P 25/04 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/07 (20130101) Heterocyclic Compounds C07D 489/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203066 | Gray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas G. Gray (Cleveland, Ohio); Joseph J. Mihaly (Youngstown, Ohio) |
| ABSTRACT | An organogold nonlinear optical chromophore includes gold complexed with a fluorophore optionally substituted an organophosphine ligand or an N-heterocyclic carbene ligand. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/093201 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203115 | ALVAREZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Theradaptive, Inc. (Frederick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis ALVAREZ (Lexington, Massachusetts); Todd HEIL (Mt. Airy, Maryland); David Hunt STEWART (Monrovia, Maryland); Hyeon PARK (Clarksburg, Maryland) |
| ABSTRACT | Provided herein are polypeptides that include one or more β-tricalcium phosphate (βTCP)-binding sequence(s) and uses thereof. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/908835 |
| CURRENT CPC | Peptides C07K 14/51 (20130101) C07K 14/475 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203220 | Reineke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theresa Reineke (Vadnais Heights, Minnesota); Ngoc Le (Minneapolis, Minnesota); Zhe Tan (Secaucus, New Jersey); Ramya Kumar (Saint Paul, Minnesota) |
| ABSTRACT | A compound includes a polymer associated with a biological agent. The polymer has a first (meth)acryl monomeric unit with a cationic functional group R1 and a second (meth)acryl monomeric unit with a neutral hydrophilic functional group R2. The cationic functional group R1 is chosen from amino groups and alkylamino groups, and the neutral functional group R2 is chosen from polyethylene glycol (PEG), hydroxyl (OH), phosphorylcholine (PC), and mixtures and combinations thereof. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 18/000258 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5138 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/20 (20130101) Original (OR) Class C08F 220/34 (20130101) C08F 220/286 (20200201) C08F 230/02 (20130101) C08F 2438/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203378 | Raja et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California); Kent State University (Kent, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shilpa Naresh Raja (Emeryville, California); Arjan Zoombelt (Emeryville, California); Adam Safir (Berkeley, California); Peter Palffy-Muhoray (Kent, Ohio); Robert J. Twieg (Kent, Ohio); Hiroshi Yokoyama (Kent, Ohio); Tianyi Guo (Kent, Ohio); Pawan Nepal (Kent, Ohio) |
| ABSTRACT | The present disclosure relates to formulations having one, two, or more chiral dopants, as well as materials and methods including such formulations. In particular instances, the formulation can include an achiral host, such as a nematic substance. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/928265 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/0208 (20130101) C09K 19/586 (20130101) Original (OR) Class C09K 2219/03 (20130101) C09K 2323/031 (20200801) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203557 | Petillo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Design-Zyme LLC (Lawrence, Kansas) |
| ASSIGNEE(S) | Design-Zyme LLC (Lawrence, Kansas) |
| INVENTOR(S) | Peter Albert Petillo (Lawrence, Kansas); Dwight O'Dell Deay, III (Lawrence, Kansas) |
| ABSTRACT | The present invention is broadly concerned with new in vitro glycosylation methods that provide rational approaches for producing glycosylated proteins, and the use of glycosylated proteins. In more detail, the present invention comprises methods of glycosylating a starting protein having an amino sidechain with a nucleophilic moiety, comprising the step of reacting the protein with a carbohydrate having an oxazoline moiety on the reducing end thereof, to covalently bond the amino sidechain of the starting protein with the oxazoline moiety, wherein the glycosylated protein substantially retains the structure and function of the starting protein. Target proteins include oxidase, oxidoreductase and dehydrogenase enzymes. The glycosylated proteins advantageously have molecular weights of at least about 7500 Daltons. In a further embodiment, the present invention concerns the use of glycosylated proteins, fabricated by the methods disclosed herein, in the assembly of amperometric biosensors. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/170045 |
| CURRENT CPC | Peptides C07K 1/006 (20130101) C07K 1/1077 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0004 (20130101) C12N 9/0006 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203667 | Hong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SOUTH DAKOTA BOARD OF REGENTS (Pierre, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haiping Hong (Rapid City, South Dakota); Rob Hrabe (Box Elder, South Dakota); Marius Ellingsen (Box Elder, South Dakota) |
| ABSTRACT | The present disclosure relates to anode compositions, methods of preparing the anode compositions via cold spray, and batteries having an anode comprising the anode compositions, a cathode, a separator, and an electrolyte. Preferably, the anode compositions comprise a metalloid and/or metal added in its elemental form. Preferably the batteries are lithium ion batteries. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 18/048753 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 24/04 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/386 (20130101) H01M 10/054 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203952 | Heeter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Heeter (Indianapolis, Indiana); Daniel E. Molnar, JR. (Indianapolis, Indiana); Christopher D. Hall (Indianapolis, Indiana) |
| ABSTRACT | An airfoil for use in a gas turbine engine is formed to define a cavity formed in the airfoil. The airfoil further includes at least one obstructing member arranged within the cavity and a shear-thickening fluid disposed in the cavity. A viscosity of the shear-thickening fluid increases in response to the airfoil experiencing an aeromechanic response or vibrations such that the obstruction of the movement of the thicker fluid by the obstructing member dampens the vibrations of the airfoil and reduces negative effects of a dynamic response of the airfoil. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561617 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/16 (20130101) Original (OR) Class F01D 5/147 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/961 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203953 | Glavicic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Glavicic (Avon, Indiana); Daniel E. Molnar, JR. (Lebanon, Indiana); Matthew Jordan (Indianapolis, Indiana); Michael Meyer (Greenwood, Indiana) |
| ABSTRACT | Methods for forming a blade for a gas turbine engine include altering the crystallographic texture of the blade in a discrete region relative to the surrounding locations of the blade to minimize flutter and/or mistune the blade by changing the natural frequency response of at least one mode of the blade. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564455 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/16 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/304 (20130101) F05D 2260/961 (20130101) F05D 2300/701 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204080 | Black |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph D. Black (Indianapolis, Indiana) |
| ABSTRACT | In some examples, a cone clutch assembly includes an inner cone member defining a first friction surface; an outer cone member defining a second friction surface opposing the first friction surface; and an independent friction member positioned between the first friction surface of the inner cone member and the second friction surface of the outer cone member. The inner cone member and outer cone member are configured to be selectively engaged and disengaged from each other. When the inner cone member is engaged with the outer cone member, the first friction surface of the inner cone member frictionally engages a third friction surface of the friction member, and the second friction surface of the outer cone member engages a fourth friction surface of the friction member such that rotational motion is transferred between the inner cone member and the outer cone member via the friction member. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564288 |
| CURRENT CPC | Couplings for Transmitting Rotation; Clutches; Brakes F16D 13/32 (20130101) Original (OR) Class F16D 13/66 (20130101) F16D 13/72 (20130101) F16D 13/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204420 | Nassar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abdalla R. Nassar (State College, Pennsylvania); Alexander J. Dunbar (Waltham, Massachusetts); Edward W. Reutzel (State College, Pennsylvania) |
| ABSTRACT | Embodiments of the systems can be configured to receive electromagnetic emissions of a substrate (e.g., a build material of a part being made via additive manufacturing) by a detector (e.g., a multi-spectral sensor) and generate a ratio of the electromagnetic emissions to perform spectral analysis with a reduced dependence on location and orientation of a surface of the substrate relative to the multi-spectral sensor. The additive manufacturing process can involve use of a laser to generate a laser beam for fusion of the build material into the part. The system can be configured to set the multi-spectral sensor off-axis with respect to the laser (e.g., an optical path of the multi-spectral sensor is at an angle that is different than the angle of incidence of the laser beam). This can allow the multi-spectral sensor to collect spectral data simultaneously as the laser is used to build the part. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/870051 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/20 (20210101) B22F 10/25 (20210101) B22F 10/28 (20210101) B22F 12/44 (20210101) B22F 12/45 (20210101) B22F 12/90 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/36 (20130101) Original (OR) Class G01J 3/0208 (20130101) G01J 3/443 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204719 | RAGHAVAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United Stated, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RAMACHANDRAN S RAGHAVAN (Centerville, Ohio) |
| ABSTRACT | The present invention relates to radar systems and methods of using same that are more efficient than current radar systems and methods of using same. Such radar systems and methods of using same using employs a plurality of pluses is used to make a decision on the presence or absence of a target. Such radar system and method of using same is more efficient as the position and velocity of a potential target is carried over from pulse burst to pulse burst. Thus, the radar signal structure from the target is the same, which in turn results in a high cross correlation that can used to efficiently decide if signal return is from an actual target or is due to interference. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/117168 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/40 (20130101) Original (OR) Class Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/182 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204878 | Morgan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Wesley B. Morgan (Lake Oswego, Oregon); Sufi R. Ahmed (Chandler, Arizona); Vineeth Abraham (Phoenix, Arizona); Sivakumar Yagnamurthy (Chandler, Arizona); Xiaoqian Li (Chandler, Arizona); Srikant Nekkanty (Chandler, Arizona) |
| ABSTRACT | A receptacle of a photonics package, a receptacle assembly including the receptacle, the photonics package, and a method of making the receptacle assembly. The receptacle assembly comprises: a photonics integrated circuit (PIC) including waveguides thereon; a die side lens assembly; and a rigid receptacle body including: a plug portion to receive an optical plug that includes a plug side lens assembly; a lens portion supporting the die side lens assembly and configured such that the die side lens assembly and the plug side lens assembly are aligned to one another when the optical plug is received in the plug portion; and a PIC portion bonded to the PIC such that the waveguides of the PIC are aligned to: corresponding lenses of the die side lens assembly; and corresponding lenses of the plug side lens assembly when the optical plug is received in the plug portion. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560847 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4212 (20130101) Original (OR) Class G02B 6/4239 (20130101) G02B 6/4243 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204986 | Aghamiri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia); Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neda Alsadat Aghamiri (Athens, Georgia); Yohannes Abate (Athens, Georgia); Shriram Ramanathan (West Lafayette, Indiana) |
| ABSTRACT | A metasurface for propagating phonon polaritons includes correlated oxide on a substrate and a wiring pattern of predetermined geometric shape on the surface thereof. There is a flake of van der Waals phononic exfoliable material on top of the wiring pattern/region. The wiring pattern may be formed by c-AFM or any other appropriate methods. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/071688 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0018 (20130101) Original (OR) Class G02F 1/0305 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204989 | Satko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MRL Materials Resources LLC (Beavercreek, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel P. Satko (Centerville, Ohio); Ayman A. Salem (Beavercreek, Ohio) |
| ABSTRACT | Images of samples that are illuminated with polarized light are captured. Azimuth and inclination data are extracted from the captured images. The azimuth and inclination data are used to quantify MTRs. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/178630 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/116 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230205524 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology , Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Disclosed in some examples are systems, methods, devices, and machine-readable mediums to detect and terminate programmable atomic transactions that are stuck in an infinite loop. In order to detect and terminate these transactions, the programmable atomic unit may use an instruction counter that increments each time an instruction is executed during execution of a programmable atomic transaction. If the instruction counter meets or exceeds a threshold instruction execution limit without reaching the termination instruction, the programmable atomic transaction may be terminated, all resources used (e.g., memory locks) may be freed, and a response may be sent to a calling processor. |
| FILED | Monday, February 20, 2023 |
| APPL NO | 18/111744 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/325 (20130101) G06F 9/466 (20130101) G06F 9/3004 (20130101) Original (OR) Class G06F 12/0815 (20130101) G06F 12/0875 (20130101) G06F 15/781 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230205968 | Kahng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Kahng (Del Mar, California); Bangqi Xu (San Diego, California); Seungwon Kim (San Diego, California) |
| ABSTRACT | A method for automatically creating a global routing solution for an integrated circuit. The method includes generating n original population of GR solutions. In one or more subsequent phases the method generates succeeding populations of GR solutions. The generation of each succeeding population includes determining a plurality of base GR solutions from the current population of GR solutions, determining a plurality of DRC hotspot areas within the plurality of base GR solutions, determining a plurality of patching GR solutions from which patches may be extracted, and hybridizing patching of GR solutions into base GR solutions. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/927169 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/3947 (20200101) Original (OR) Class G06F 30/3953 (20200101) G06F 2119/06 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230206107 | Carroll et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Streamline Automation LLC (Huntsville, Alabama); Wake Forest University (Winston Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Carroll (Winston Salem, North Carolina); Alton J. Reich (Huntsville, Alabama); Roberto Di Salvo (Cincinnati, Ohio) |
| ABSTRACT | A method for monitoring the state of a qubit device comprising a chiral nanocrystal includes measuring a voltage, a current, or a magnetic field of the nanocrystal; assigning the nanocrystal a superposition state if the measured voltage, current, or magnetic field is less than a superposition threshold; and assigning a base state value of the nanocrystal if the measured voltage is greater than a base state threshold. The measured voltage, current, or magnetic field corresponds to a clockwise or counter clockwise flow of electrons around the nanocrystal. |
| FILED | Monday, January 16, 2023 |
| APPL NO | 18/097328 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 29/423 (20130101) H01L 29/66977 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230206110 | Jiang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liang Jiang (Chicago, Illinois); Filip D. Rozpedek (Chicago, Illinois); Kyungjoo Noh (Pasadena, California) |
| ABSTRACT | Quantum repeaters and network architectures use two concatenated quantum error correction codes to increase the transmission range of quantum information. A block of data qubits collectively encode a second-layer logical qubit according to a second-layer code concatenated with a first-layer code. A first-layer quantum repeater first-layer corrects each data qubit based on a first-layer syndrome extracted therefrom. The first-layer quantum repeater transmits these first-layer-corrected qubits to a second-layer quantum repeater via a quantum communication channel. The first-layer quantum repeater also transmits the first-layer syndromes to the second-layer quantum repeater via a classical communication channel. After extracting a second-layer syndrome from the first-layer-corrected qubits, the second-layer quantum repeater uses the first-layer syndromes and second-layer syndrome to second-layer correct the first-layer-corrected qubits. The first-layer syndromes improve quantum error correction by reducing the number of sec-and-layer stabilizer measurements needed to determine which data qubits have an error. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/000074 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/70 (20220101) Original (OR) Class Transmission H04B 10/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230206387 | Mai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Naval Information Warfare Center, Pacific (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by Secretary of the Navy (San Diego, California) |
| INVENTOR(S) | Adrian Mai (San Diego, California); Mark Bilinski (Vista, California); Raymond Chey Provost (San Diego, California) |
| ABSTRACT | The present invention relates to a systems and methods to perform 3D localization of target objects in point cloud data using a corresponding 2D image. According to an illustrative embodiment of the present disclosure, a target environment is imaged with a camera to generate a 2D panorama and a scanner to generate a 3D point cloud. The 2D panorama is mapped to the point cloud with a 1 to 1 grid map. The target objects are detected and localized in 2D before being mapped back to the 3D point cloud. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561028 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/89 (20130101) Image Data Processing or Generation, in General G06T 3/0031 (20130101) Original (OR) Class G06T 3/0087 (20130101) Image or Video Recognition or Understanding G06V 20/63 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230206413 | McCall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian McCall (Dallas, Texas); Wensheng Fan (Plano, Texas); Jason Dwight (Dallas, Texas); Zhicun Gao (Plano, Texas); Jeffrey E. Thatcher (Irving, Texas); John Michael DiMaio (Dallas, Texas) |
| ABSTRACT | Generally described, one or more aspects of the present application correspond to systems and techniques for spectral imaging using a multi-aperture system with curved multi-bandpass filters positioned over each aperture. The present disclosure further relates to techniques for implementing spectral unmixing and image registration to generate a spectral datacube using image information received from such imaging systems. Aspects of the present disclosure relate to using such a datacube to analyze the imaged object, for example to analyze tissue in a clinical setting, perform biometric recognition, or perform materials analysis. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/178875 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 7/33 (20170101) G06T 7/55 (20170101) G06T 7/62 (20170101) G06T 2207/10036 (20130101) G06T 2207/10144 (20130101) G06T 2207/20221 (20130101) Pictorial Communication, e.g Television H04N 5/265 (20130101) H04N 23/55 (20230101) H04N 23/56 (20230101) H04N 23/743 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230207146 | Yu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhibin Yu (Tallahassee, Florida) |
| ABSTRACT | Composite materials that may include particles of an inorganic material and an elastic polymer. The composite materials may be in the form of a flexible film. The composite materials may provide radiation shielding. Articles on or in which a composite material is disposed. Methods of forming composite materials. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/059729 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/05 (20130101) A41D 31/04 (20190201) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/212 (20130101) C08J 5/18 (20130101) C08J 2353/02 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 1/103 (20130101) Original (OR) Class G21F 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230207149 | CAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lei Raymond CAO (Columbus, Ohio); Lei PAN (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are charge or electricity generating devices and methods of making and use thereof. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/921522 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 4/04 (20130101) Obtaining Energy From Radioactive Sources; Applications of Radiation From Radioactive Sources, Not Otherwise Provided For; Utilising Cosmic Radiation G21H 1/06 (20130101) G21H 1/12 (20130101) Original (OR) Class G21H 3/02 (20130101) Organic electric solid-state devices H10K 50/813 (20230201) H10K 50/822 (20230201) H10K 59/60 (20230201) H10K 85/30 (20230201) H10K 85/50 (20230201) H10K 2102/20 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230207323 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Travis J. Anderson (Alexandria, Virginia); James C. Gallagher (Alexandria, Virginia); Marko J. Tadjer (Vienna, Virginia); Alan G. Jacobs (Arlington, Virginia); Boris N. Feigelson (Springfield, Virginia) |
| ABSTRACT | A method for activating implanted dopants and repairing damage to dopant-implanted GaN to form n-type or p-type GaN. A GaN substrate is implanted with n- or p-type ions and is subjected to a high-temperature anneal to activate the implanted dopants and to produce planar n- or p-type doped areas within the GaN having an activated dopant concentration of about 1018-1022 cm−3. An initial annealing at a temperature at which the GaN is stable at a predetermined process temperature for a predetermined time can be conducted before the high-temperature anneal. A thermally stable cap can be applied to the GaN substrate to suppress nitrogen evolution from the GaN surface during the high-temperature annealing step. The high-temperature annealing can be conducted under N2 pressure to increase the stability of the GaN. The annealing can be conducted using laser annealing or rapid thermal annealing (RTA). |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116000 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/266 (20130101) H01L 21/3245 (20130101) H01L 21/26546 (20130101) Original (OR) Class H01L 21/28575 (20130101) H01L 29/36 (20130101) H01L 29/207 (20130101) H01L 29/452 (20130101) H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230208054 | Eid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aline Eid (Atlanta, Georgia); Jimmy Georges Donald Hester (Atlanta, Georgia); Emmanouil Tentzeris (Atlanta, Georgia) |
| ABSTRACT | The disclosed technology includes device, systems, techniques, and methods for mm-wave backscattering and energy harvesting systems utilizing a Rotman-Lens-based rectenna system. An mm-wave backscattering and energy harvesting system can include one or more antenna, a Rotman Lens having a beam port side and an antenna side in electrical communication with the one or more antenna, and a switching network in electrical communication with the beam port side of the Rotman Lens. The switching network can be configured to cause the system to operate in either a backscattering mode or an energy harvesting mode. |
| FILED | Friday, June 18, 2021 |
| APPL NO | 18/008244 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/248 (20130101) H01Q 21/0031 (20130101) H01Q 25/008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230208074 | Wallin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan Wallin (Freeport, Illinois); Jessica M. Friedberg (Stillman Valley, Illinois); Michael J. DeVito (Loves Park, Illinois); Calvin Eads (Lafayette, Indiana) |
| ABSTRACT | Provided are embodiments for an electrical connector system. Embodiments include an electrical connector and a support ring where the support ring includes a baseplate having a first side and a second side, a recessed portion on a first side of a baseplate for a primary O-ring, and a sidewall extending from the second base plate. Embodiments also include a housing coupled to the support ring, wherein the sidewall extends into the housing, wherein the support ring is coupled to the electrical connector on the first side, and the support ring is coupled to the housing on the second side. Also provided are embodiments for the support ring and assembling the electrical connector system. |
| FILED | Thursday, September 03, 2020 |
| APPL NO | 17/011294 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/5202 (20130101) Original (OR) Class H01R 43/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230208516 | Corzine et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Government of the United States of America, as Represented by the Secretary of the Navy (Monterey, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); The Government of the United States of America, as Represented by the Secretary of the Navy (Monterey, California) |
| INVENTOR(S) | Keith Corzine (Santa Cruz, California); Todd Weatherford (Santa Cruz, California); Matthew Porter (Santa Cruz, California) |
| ABSTRACT | An optically-monitored and/or optically-controlled electronic device is described. The device includes at least one of a semiconductor transistor or a semiconductor diode. An optical detector is configured to detect light emitted by the at least one of the semiconductor transistor or the semiconductor diode during operation. A signal processor is configured to communicate with the optical detector to receive information regarding the light detected. The signal processor is further configured to provide information concerning at least one of an electrical current flowing in, a temperature of, or a condition of the at least one of the semiconductor transistor or the semiconductor diode during operation. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/113500 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/28 (20130101) Optical Elements, Systems, or Apparatus G02B 6/12007 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/32 (20130101) Transmission H04B 10/071 (20130101) Original (OR) Class H04B 10/801 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230208628 | Krastanov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan Ivanov Krastanov (Boston, Massachusetts); Hamza Raniwala (Cambridge, Massachusetts); Hanfeng WANG (Cambridge, Massachusetts); Matthew Edwin TRUSHEIM (Cambridge, Massachusetts); Laura KIM (Belmont, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | A 1D diamond nanobeam can act as a coherent mechanical interface between spin defect centers in diamond and telecom optical modes. The nanobeam includes embedded mechanical and electric field concentrators with mechanical and optical mode volumes of Vmech/Λp3 ˜10−5 and Vopt/λ3 ˜10−3, respectively. With a Group IV vacancy in the concentrator, the nanobeam can operate at spin-mechanical coupling rates approaching 40 MHz with high acousto-optical couplings. This nanobeam, used in an entanglement heralding scheme, can provide high-fidelity Bell pairs between quantum repeaters. Using the mechanical interface as an intermediary between the optical and spin subsystems enables addressing the spin defect center with telecom optics, bypassing the native wavelength of the spin. As the spin is never optically excited or addressed, the device can operate at temperatures up to 40 K with no appreciable spectral diffusion, limited by thermal losses. Optomechanical devices with high spin-mechanical coupling can be useful for quantum repeaters. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/146085 |
| CURRENT CPC | Transmission H04B 10/70 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0855 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230208778 | Le et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thai Franck Le (White Plains, New York); Erich M. Nahum (New York, New York) |
| ABSTRACT | A queue management method, system, and recording medium include Selective Acknowledgments (SACK) examining to examine SACK blocks of the forwarder to selectively drop packets in the forward flow queue based on a reverse flow queue and MultiPath Transmission Control Protocol (MPTCP) examining configured to examine multipath headers to recognize MPTCP flows and examine the reverse flow queue to determine if redundant data has been sent such that the dropping drops the redundant data. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/113665 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 47/32 (20130101) H04L 47/40 (20130101) H04L 47/627 (20130101) Original (OR) Class H04L 47/6255 (20130101) H04L 47/6275 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210006 | Forrest et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan); Yongxi Li (Ann Arbor, Michigan) |
| ABSTRACT | Organic photovoltaic cells (OPVs) and their compositions are described herein. In one or more embodiments, the acceptor with an active layer of an OPV includes is a non-fullerene acceptor. Such non-fullerene acceptors may provide improved OPV performance characteristics such as improved power conversion efficiency, open circuit voltage, fill factor, short circuit current, and/or external quantum efficiency. One example of a non-fullerene acceptor is (4,4,10,10-tetrakis(4-hexylphenyl)-5,11-(2-ethylhexyloxy)-4,10-dihydro-dithienyl[1,2-b:4,5b′]benzodi-thiophene-2,8-diyl) bis(2-(3-oxo-2,3-dihydroinden-5,6-dichloro-1-ylidene) malononitrile. |
| FILED | Tuesday, February 21, 2023 |
| APPL NO | 18/171747 |
| CURRENT CPC | Heterocyclic Compounds C07D 495/22 (20130101) Organic electric solid-state devices H10K 30/30 (20230201) H10K 85/621 (20230201) H10K 85/6576 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210008 | Fish |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. Fish (Arlington, Virginia) |
| ABSTRACT | A thermal energy storage (TES) device includes a thermoelectric cooler; and a metallic phase change material (PCM) within the thermoelectric cooler. The PCM may include any of gallium or its alloys, low temperature fusible alloys, and solid metal shape memory alloys. A thermoelectric effect within the PCM is to transport heat in the thermoelectric cooler. The TES device may include a graded oxide layer adjacent to the PCM to serve as a distributed electrical junction in the thermoelectric cooler to create a hot side thermoelectric junction in a bulk volume of the PCM. The graded oxide layer may include α-IGZO. The TES device may include a high-thermopower corrugated metal foil layer comprising barrier oxides patterned therein. The high-thermopower metal foil layer may be adjacent to the graded oxide layer. The TES device may include a dielectric layer adjacent to the high-thermopower corrugated metal foil layer. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/116873 |
| CURRENT CPC | Electric solid-state devices not otherwise provided for H10N 10/13 (20230201) Original (OR) Class H10N 10/17 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230200382 | Sumerlin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent S. Sumerlin (Gainesville, Florida); Shaun Paul Jensen (Gainesville, Florida); Megan R. Hill (Gainesville, Florida); Mingsheng Chen (Gainesville, Florida); Gloria A. Moore (Gainesville, Florida); Zhenli L. HE (Gainesville, Florida); Sangwoo Park (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for compositions including polymer particles, methods of making compositions, methods of using the composition, stimuli-responsive methods of delivering agents, and the like. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/979857 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) A01N 25/28 (20130101) Original (OR) Class Mixtures of Fertilisers Covered Individually by Different Subclasses of Class C05; Mixtures of One or More Fertilisers With Materials Not Having a Specific Fertilising Activity, e.g Pesticides, Soil-conditioners, Wetting Agents; Fertilisers Characterised by Their Form C05G 5/37 (20200201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230200395 | Reynolds et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa M. Reynolds (Fort Collins, Colorado); Megan J. Neufeld (Portland, Oregon); Bella H. Neufeld (Fort Collins, Colorado); Alec Lutzke (Fort Collins, Colorado) |
| ABSTRACT | A substrate having an antibacterial surface includes a chitosan matrix and water-stable metal-organic frameworks dispersed throughout the chitosan matrix. The water-stable metal-organic frameworks are present in an amount of 5% wt/wt to 20% wt/wt based on total solids of the substrate. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/115789 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) A01N 55/02 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/18 (20130101) A61L 2/23 (20130101) A61L 2101/42 (20200801) Polysaccharides; Derivatives Thereof C08B 37/003 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201013 | Hong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Solinas Medical Inc. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Hong (Santa Clara, California); Erik van der Burg (Los Gatos, California); Amy Lee (Sunnyvale, California) |
| ABSTRACT | A self-sealing tubular graft is provided for implantation within a patient's body that includes an elongate tubular body including first and second self-sealing cannulation regions and a loop region extending between the first and second cannulation regions. The loop region includes one or more reinforcement members attached to a first length of the loop region and extending at least partially around a circumference of the tubular body. For example, the reinforcement members may include one or more sinusoidal or zigzag members extending along the first length with alternating peaks and valleys extending at least partially around a circumference of the tubular body. Self-sealing patches are also provided that include one or more reinforcement members embedded within base material. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116197 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/06 (20130101) A61F 2/07 (20130101) A61F 2/82 (20130101) A61F 2/88 (20130101) A61F 2/89 (20130101) Original (OR) Class A61F 2/885 (20130101) A61F 2002/072 (20130101) A61F 2230/0069 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3655 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201354 | Demirci et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hakan Demirci (Ann Arbor, Michigan); Nicholas Kotov (Ann Arbor, Michigan); Yichun Wang (Ann Arbor, Michigan) |
| ABSTRACT | Disclosed herein are compositions and methods for injecting compounds into a vitreous body. Carbon nanotubes can be functionalized with a variety of agents, such as therapeutic agents and/or diagnostic agents, which can be injected into a vitreous body for treatment or detection of ocular tumors such as retinoblastoma. The carbon nanotubes can effectively penetrate the ocular tumor, making them effective carriers for the therapeutic and/or diagnostic agents. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/998761 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0092 (20130101) A61K 45/06 (20130101) A61K 47/52 (20170801) Original (OR) Class A61K 47/6929 (20170801) A61K 49/0017 (20130101) A61K 49/0095 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/159 (20170801) C01B 2202/34 (20130101) C01B 2202/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201901 | TAKATA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KEYSTONE TOWER SYSTEMS, INC. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosalind K. TAKATA (Denver, Colorado); Loren Daniel BRIDGERS (Golden, Colorado); Eric D. SMITH (Denver, Colorado) |
| ABSTRACT | Spiral forming devices, systems, and methods can be used to join edges of a of a stock material, in a curved configuration, along one or more joints to form tubular structures, such as conical and/or cylindrical structures (e.g., frusto-conical structures). A planar form of the stock material can be formed from a plurality planar sheets coupled to one another in an abutting relationship. By controlling relative orientation and shapes of the plurality of planar sheets forming the stock material and/or by controlling a position of a roll bender used to curve the planar form of the stock material into the curved configuration, the curved configuration of the stock material can be controlled through transitions between sheets to facilitate rolling the sheets to a desired diameter with a reduced likelihood of dimples or other errors and to facilitate fit up between adjacent sheets in the curved configuration. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/084368 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/185 (20130101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 31/027 (20130101) Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General E04H 12/08 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/728 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201927 | Wood et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathaniel Joseph Wood (Columbus, Ohio); David John Hoelzle (Columbus, Ohio) |
| ABSTRACT | Estimation algorithms, methods, and systems are provided that estimate the internal temperatures inside of a part being built using powder bed fusion (PBF). Closed-loop state estimation is applied to the problem of monitoring temperature fields within parts during the PBF build process. A simplified linear time-invariant (LTI) model of PBF thermal physics with the properties of stability, controllability and observability is presented. In some aspects, Model Predictive Control (MPC) may be used as an expanded application of an Ensemble Kalman Filter (EnKF) methods to control the PBF process. MPC is used to forecast the PBF build process behavior N time steps into the future and identifies inputs that drive the temperature of a corresponding node in a mesh of n nodes towards a predetermined target temperature. The inputs are |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054534 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) Original (OR) Class B22F 10/85 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/041 (20130101) G05B 13/048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202840 | Flanders et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Twelve Benefit Corporation (Berkeley, California) |
| ASSIGNEE(S) | Twelve Benefit Corporation (Berkeley, California) |
| INVENTOR(S) | Nicholas H. Flanders (San Francisco, California); Kendra P. Kuhl (Oakland, California); Carter S. Haines (Berkeley, California); Luka Stevic (Novi Sad, Serbia); Gregory DiCosola (Redmond, Washington) |
| ABSTRACT | A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 18/052845 |
| CURRENT CPC | Separation B01D 53/326 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/382 (20130101) Original (OR) Class C01B 2203/042 (20130101) C01B 2203/062 (20130101) C01B 2203/0475 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 1/23 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202844 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Joohoon Kang (Evanston, Illinois) |
| ABSTRACT | Preparation of two-dimensional indium selenide, other two-dimensional materials and related compositions via surfactant-free deoxygenated co-solvent systems. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/115224 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/77 (20130101) C01P 2002/82 (20130101) C01P 2002/85 (20130101) C01P 2004/04 (20130101) C01P 2004/24 (20130101) C01P 2006/40 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/032 (20130101) H01L 31/035227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202940 | Noe-Hays et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Abraham Noe-Hays (Ann Arbor, Michigan); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abraham Noe-Hays (Putney, Vermont); Nancy Love (Ann Arbor, Michigan) |
| ABSTRACT | A system for generating a concentrated product from a feedstock includes a feedstock chamber to which the feedstock is provided, a heat exchanger assembly in thermal communication with the feedstock chamber, the heat exchanger assembly being configured to freeze the feedstock in the feedstock chamber, an output flow arrangement configured to carry liquid from the feedstock chamber as the feedstock thaws, the output flow arrangement comprising a flow controller, a sensor disposed along the output flow arrangement or the heat exchanger assembly, the sensor being configured to measure a characteristic of the liquid, the characteristic being indicative of a solute concentration level of the liquid or the heat exchanger assembly, and a processor responsive to the characteristic and configured to control the flow controller to, based on the solute concentration level, direct the liquid passing through the output flow arrangement to define a plurality of products at different concentration levels, the plurality of products comprising the concentrated product. |
| FILED | Tuesday, February 14, 2023 |
| APPL NO | 18/109572 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 2/12 (20130101) Separation B01D 9/04 (20130101) B01D 9/0013 (20130101) B01D 9/0059 (20130101) B01D 9/0063 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/22 (20130101) Organic Fertilisers Not Covered by Subclasses C05B, C05C, e.g Fertilisers From Waste or Refuse C05F 3/00 (20130101) C05F 3/06 (20130101) Original (OR) Class Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 29/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4055 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/145 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203052 | ISAACS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lyle David ISAACS (Silver Spring, Maryland); Xiaoyong LU (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed herein are acyclic sulfated cucurbit[n]uril containing sulfate substituent(s), compositions containing the same, and method of preparation thereof. These compounds are useful, for example, as sequestering agents for drugs of abuse. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/996821 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/547 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Heterocyclic Compounds C07D 487/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203077 | HAZARI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nilay HAZARI (New Haven, Connecticut); Patrick MELVIN (New Haven, Connecticut); Damian HRUSZKEWYCZ (New Haven, Connecticut) |
| ABSTRACT | The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable and moisture-stable. The present invention further provides methods of making and using the precatalysts of the invention. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/175357 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 2602/10 (20170501) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 17/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203110 | St-Pierre et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | François St-Pierre (Houston, Texas); Jihwan Lee (Houston, Texas); Zhuohe Liu (Houston, Texas) |
| ABSTRACT | Provided herein are photostable fluorescent proteins and methods of making and using those proteins. A photostable fluorescent protein variant is provided comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:3, wherein the amino acid sequence comprises a first substitution at a residue corresponding to residue 46 of a polypeptide of SEQ ID NO:2 and a second substitution at a residue corresponding to residue 63 of the polypeptide of SEQ ID NO:2, and the variant is more photostable than the polypeptide of SEQ ID NO:2. A method of detecting a protein of interest is also provided, comprising the steps of expressing a fusion protein and detecting the fluorescence of the fusion protein, thereby detecting the protein of interest. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/759323 |
| CURRENT CPC | Peptides C07K 14/43595 (20130101) Original (OR) Class C07K 2319/60 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203264 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng Jiang (Gainesville, Florida); Calen Leverant (Gainesville, Florida); Yifan Zhang (Gainesville, Florida) |
| ABSTRACT | Provided herein are methods for fabricating a porous polymer material, methods for revealing hidden anti-counterfeiting patterns, chromogenic sensors having hidden anti-counterfeiting patterns, and the like. Chromogenic sensors including porous polymer materials are provided. The chromogenic sensors can reveal hidden patterns such as anti-counterfeiting patterns and the pattern can be re-hidden. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/926776 |
| CURRENT CPC | Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/36 (20141001) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 222/102 (20200201) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/26 (20130101) Original (OR) Class C08J 9/36 (20130101) C08J 2201/044 (20130101) C08J 2201/0462 (20130101) C08J 2335/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203512 | Maliga et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| ASSIGNEE(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| INVENTOR(S) | Pal Maliga (East Brunswick, New Jersey); Aki Matsuoka (Highland Park, New Jersey) |
| ABSTRACT | Compositions and methods for agrobacterium-mediated chloroplast transgene expression are provided. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/813667 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 15/8205 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/01 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203692 | AKKUS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ozan AKKUS (Cleveland Heights, Ohio); Mousa YOUNESI (Shaker Heights, Ohio); Umit Levent EROL (Cleveland Heights, Ohio) |
| ABSTRACT | A method for producing an electrocompacted and aligned strand is disclosed. The method includes the steps of: providing a channel having an anode on one side and a cathode on the other side separated by a non-conductive material to form an electrode; dispensing a solution comprising one or more electrocompactable and alignable molecules, nanoparticles or microparticles with ampholytic nature into the channel to complete a circuit between the anode and the cathode; applying a DC current in the range of 1-200 volts to the electrode through the solution in the channel to form an electrocompacted and aligned strand; and transferring the aligned strand out of the electrode. The one or more electrocompactable and alignable molecules, nanoparticles or microparticles with ampholytic nature can comprise collagen molecules that have different charges at different pH values. Materials including electrochemically aligned and compacted compounds are also disclosed. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169365 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/04 (20130101) Original (OR) Class Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/00 (20130101) D01D 10/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203712 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wenzhi Li (Palmetto Bay, Florida); Yuba Poudel (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Wenzhi Li (Palmetto Bay, Florida); Yuba Poudel (Miami, Florida) |
| ABSTRACT | Filled carbon nanotubes (CNTs) and methods of synthesizing the same are provided. An in situ chemical vapor deposition technique can be used to synthesize CNTs filled with metal sulfide nanowires. The CNTs can be completely and continuously filled with the metal sulfide fillers up to several micrometers in length. The filled CNTs can be easily collected from the substrates used for synthesis using a simple ultrasonication method. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/151309 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/162 (20170801) C01B 32/178 (20170801) C01B 2202/06 (20130101) C01B 2202/10 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2002/84 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/186 (20130101) C30B 29/46 (20130101) C30B 29/66 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204533 | Henry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| INVENTOR(S) | Charles S. Henry (Fort Collins, Colorado); Tugba Ozer (Fort Collins, Colorado) |
| ABSTRACT | The present disclosure provides potentiometric ion selective electrodes, methods for preparing the potentiometric ion selective electrode, a microfluidic electrode array comprising the potentiometric ion selective electrodes, and methods of using the microfluidic electrode array to measure inorganic cations and inorganic anions in a solution. |
| FILED | Wednesday, December 28, 2022 |
| APPL NO | 18/089858 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/333 (20130101) Original (OR) Class G01N 27/416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204690 | Javor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Joshua Javor (Cambridge, Massachusetts); David Bishop (Brookline, Massachusetts); David Campbell (Brookline, Massachusetts); Matthias Imboden (St. Blaise, Switzerland) |
| ABSTRACT | A gradiometer includes a at least one magnet attached to a beam. The magnet moves in response to a magnetic force. A sensing element is configured to measure movement or deflection of the beam or magnet. The gradiometer is configured to determine a gradient of a magnetic field acting on the first magnet based on movement of the magnet. The gradiometer can further measure higher order gradients. |
| FILED | Tuesday, February 21, 2023 |
| APPL NO | 18/112229 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/022 (20130101) Original (OR) Class G01R 33/038 (20130101) G01R 33/0052 (20130101) G01R 33/0385 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204704 | Friedrichs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaeron R. Friedrichs (Boulder, Colorado); Mohamed A. Elmansouri (Boulder, Colorado); Dejan S. Filipovic (Boulder, Colorado) |
| ABSTRACT | A computer system for angle of arrival estimation receives one or more snapshots from a circular array of antennas. The computer system processes the one or more snapshots for amplitude and/or phase-based direction finding using two cascaded algorithms. The first algorithm of the two cascaded algorithms is configured to identify a target subregion from which a signal arrives. The second algorithm of the two cascaded algorithms is configured to identify a direction of the signal within the target subregion. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089018 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 3/46 (20130101) Original (OR) Class G01S 3/64 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230205729 | Gu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Gu (Evanston, Illinois); Yuhao Ju (Evanston, Illinois) |
| ABSTRACT | A systolic neural CPU (SNCPU) including a two-dimensional systolic array of reconfigurable processing elements (PE's) fuses a conventional CPU with a convolutional neural network (CNN) accelerator in four phases of operation: row-CPU, column-accelerator, column-CPU, and row-accelerator. The SNCPU cycles through the four phases to avoid costly data movement across cores, reduce overhead, and reduce latency. The PE's communicate bidirectionally with neighboring PE's and memory units at an outer edge of the array. A row of PE's is configurable into a first deep neural network (DNN) accumulator at a first time and configurable into a first CPU pipeline at a second time. A column of PE's is configurable into a second DNN accumulator at a third time and configurable into a second CPU pipeline at a fourth time. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/146048 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5027 (20130101) G06F 15/8046 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230206106 | Lindner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Passadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); Technion Research and Development Foundation Limited (Haifa, Israel) |
| INVENTOR(S) | Netanel H. Lindner (Aviel, Israel); Soonwon Choi (El Cerrito, California); John P. Preskill (Pasadena, California) |
| ABSTRACT | The present disclosure describes an interferometer interfering a plurality of bosonic particles at one or more inputs so as to form one or more first outputs, one or more second outputs, and one or more third outputs. The one or more third outputs output one or more purified bosonic particles depending on the presence of absence of bosonic particles at the first outputs and second outputs. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/077863 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230206110 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liang Jiang (Chicago, Illinois); Filip D. Rozpedek (Chicago, Illinois); Kyungjoo Noh (Pasadena, California) |
| ABSTRACT | Quantum repeaters and network architectures use two concatenated quantum error correction codes to increase the transmission range of quantum information. A block of data qubits collectively encode a second-layer logical qubit according to a second-layer code concatenated with a first-layer code. A first-layer quantum repeater first-layer corrects each data qubit based on a first-layer syndrome extracted therefrom. The first-layer quantum repeater transmits these first-layer-corrected qubits to a second-layer quantum repeater via a quantum communication channel. The first-layer quantum repeater also transmits the first-layer syndromes to the second-layer quantum repeater via a classical communication channel. After extracting a second-layer syndrome from the first-layer-corrected qubits, the second-layer quantum repeater uses the first-layer syndromes and second-layer syndrome to second-layer correct the first-layer-corrected qubits. The first-layer syndromes improve quantum error correction by reducing the number of sec-and-layer stabilizer measurements needed to determine which data qubits have an error. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/000074 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/70 (20220101) Original (OR) Class Transmission H04B 10/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230207879 | Nagarajan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sudhan Nagarajan (Detroit, Michigan); Leela Mohana Reddy Arava (Troy, Michigan) |
| ABSTRACT | A method of forming a thermally stable film on a cathode surface that allows reversable lithiation and delithiation reactions at high temperatures without structural degradations may include introducing a functional additive containing at least one of fluorine, boron, and phosphorus to an electrolyte, operating a first charge-discharge cycle of a lithium-ion battery with a cathode surface at 100° C., decomposing the functional additives during the first charge-discharge cycle, and forming a cathode electrolyte interphase film on the cathode surface from products of the functional additive decomposition. The cathode electrolyte interphase film may reduce contact between the cathode surface and the electrolyte in subsequent charge-discharge cycles of the lithium-ion battery. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/085879 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/525 (20130101) H01M 4/1391 (20130101) H01M 10/446 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230207998 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Tengxing Wang (Columbia, South Carolina); Guoan Wang (Irmo, South Carolina) |
| ABSTRACT | An electrically tunable radio frequency phase shifter with compact 3-D structure that integrates both ferromagnetic and ferroelectric materials, and utilizes 3-D structure to increase the tuning efficiency and achieve miniaturization. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/170062 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 21/08 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/181 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 3/36 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/20 (20130101) H03H 2210/033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230208104 | TAMAGNONE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Michele TAMAGNONE (Cambridge, Massachusetts); Marco PICCARDO (Milano, Italy); Dmitry KAZAKOV (Somerville, Massachusetts); Christina Maria SPÄGELE (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | A laser device includes a gain medium including a facet. The laser device includes a metasurface including a plurality of supercells. The metasurface is disposed on a substrate and configured to reflect and focus a first portion of light from the facet back to the gain medium as a feedback beam. The metasurface can be configured to reflect a second portion of the light as an output beam at an angle that is nonzero relative to a direction of the feedback beam. The metasurface can be configured to transmit a second portion of the light as an output beam through the metasurface away from the facet. The emission wavelength of the laser device can be tuned by translating the metasurface. The output beam can be collimated towards a fixed direction while tuning the wavelength. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/923886 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) G02B 26/0816 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/141 (20130101) Original (OR) Class H01S 5/0283 (20130101) H01S 5/0687 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230208322 | JOHNSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Blake JOHNSON (Pembroke, Virginia); Yuxin TONG (Blacksburg, Virginia); John ROBERTSON (Floyd, Virginia); Xiaoting JIA (Blacksburg, Virginia); Ziang FENG (Blacksburg, Virginia) |
| ABSTRACT | A fabrication process is disclosed for the production of flexible triboelectric nanogenerator (TENG) fiber, which can comprise a copper core surrounded by a silicone cladding. The TENG fibers are fabricated using a coaxial micro-extrusion process that enables 2D and 3D constructs to be fabricated with the fibers via 3D printing on both stationary and moving substrates to form mechanosensors as membranes, meshes, and hollow 3D structures. The mechanosensors can be integrated into wearable items for human activity monitoring, or can be formed on organs for organ monitoring, e.g., monitoring of perfused organs. The mechanosensors can be integrated into facemasks and uses for silent speech recognition, such as words mouthed in the absence of sound production by the speaker. The mechanosensors are self-powered and have high stretchability. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/996288 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4878 (20130101) A61B 5/6804 (20130101) Electric Machines Not Otherwise Provided for H02N 1/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230208373 | ODAME et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kofi ODAME (Hanover, New Hampshire); Yueh-Ching TENG (Lebanon, New Hampshire) |
| ABSTRACT | An amplitude detector has a phase shifter such as one using an analog differentiator and an adjustable gain stage, or one using a determinable delay, the phase shifter coupled to shift phase of an input signal to the amplitude detection apparatus. The detector also has a first analog multiplier coupled to square the input signal, a second analog multiplier coupled to square output of the phase shifter; and an analog adder coupled to sum outputs of the first and second analog multiplier. An automatic gain control circuit has the amplitude detector coupled to control gain of a controllable amplifier. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/116755 |
| CURRENT CPC | Amplifiers H03F 3/24 (20130101) Control of Amplification H03G 3/3036 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230208628 | Krastanov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan Ivanov Krastanov (Boston, Massachusetts); Hamza Raniwala (Cambridge, Massachusetts); Hanfeng WANG (Cambridge, Massachusetts); Matthew Edwin TRUSHEIM (Cambridge, Massachusetts); Laura KIM (Belmont, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | A 1D diamond nanobeam can act as a coherent mechanical interface between spin defect centers in diamond and telecom optical modes. The nanobeam includes embedded mechanical and electric field concentrators with mechanical and optical mode volumes of Vmech/Λp3 ˜10−5 and Vopt/λ3 ˜10−3, respectively. With a Group IV vacancy in the concentrator, the nanobeam can operate at spin-mechanical coupling rates approaching 40 MHz with high acousto-optical couplings. This nanobeam, used in an entanglement heralding scheme, can provide high-fidelity Bell pairs between quantum repeaters. Using the mechanical interface as an intermediary between the optical and spin subsystems enables addressing the spin defect center with telecom optics, bypassing the native wavelength of the spin. As the spin is never optically excited or addressed, the device can operate at temperatures up to 40 K with no appreciable spectral diffusion, limited by thermal losses. Optomechanical devices with high spin-mechanical coupling can be useful for quantum repeaters. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/146085 |
| CURRENT CPC | Transmission H04B 10/70 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0855 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230208858 | Mishra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabhat Kumar Mishra (Gainesville, Florida); Zhixin Pan (Gainesville, Florida) |
| ABSTRACT | Various embodiments of the present disclosure provide systems, methods, and computer program products for detecting unauthorized memory access cyberattacks, such as Spectre and Meltdown, which are intended to maliciously reveal information stored in concealed or restricted memory of a targeted device. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 18/045563 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230209223 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gigajot Technology, Inc. (Pasadena, California) |
| ASSIGNEE(S) | Gigajot Technology, Inc. (Pasadena, California) |
| INVENTOR(S) | Jiaju Ma (Monrovia, California); Saleh Masoodian (Monrovia, California) |
| ABSTRACT | Correlated double sampling column-level readout of an image sensor pixel (e.g., a CMOS image sensor) may be provided by a charge transfer amplifier that is configured and operated to itself provide for both correlated-double-sampling and amplification of floating diffusion potentials read out from the pixel onto a column bus after reset of the floating diffusion (i) but before transferring photocharge to the floating diffusion (the reset potential) and (ii) after transferring photocharge to the floating diffusion (the transfer potential). A common capacitor of the charge transfer amplifier may sample both the reset potential and the transfer potential such that a change in potential (and corresponding charge change) on the capacitor represents the difference between the transfer potential and reset potential, and the magnitude of this change is amplified by the charge change being transferred between the common capacitor and a second capacitor selectively coupled to the common capacitor. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 18/058722 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14612 (20130101) Pictorial Communication, e.g Television H04N 25/59 (20230101) H04N 25/65 (20230101) H04N 25/75 (20230101) Original (OR) Class H04N 25/616 (20230101) H04N 25/778 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230209839 | SHIELD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeff SHIELD (Lincoln, Nebraska); Zahra AHMADI (Lincoln, Nebraska) |
| ABSTRACT | Disclosed herein are core/shell nanoparticles each comprising a metallic core; a shell formed of a metal oxide and surrounding the metallic core; wherein the nanoparticle is characterized by bipolar resistive switching in response to an applied voltage or current. Also disclosed are devices comprising such nanoparticles, as well as methods of using and methods of making such devices. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/110751 |
| CURRENT CPC | Static Stores G11C 11/54 (20130101) G11C 13/0002 (20130101) Electronic Memory Devices H10B 63/24 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230209845 | LUNT, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Royal LUNT, III (Williamston, Michigan); Christopher HERRERA (Haslett, Michigan); Chenchen YANG (Holt, Michigan); Aria VAHDANI (East Lansing, Michigan); Babak BORHAN (Okemos, Michigan) |
| ABSTRACT | A solar panel includes a substrate and a photoactive material. The photoactive material includes an ion and a counterion. An absolute magnitude of a binding energy between the ion and the counterion is less than or equal to about 6.5. A majority of available hydrogen sites on the counterion may be halogenated. A water contact angle of the photoactive material may be greater than or equal to about 65°. The solar panel may be a photovoltaic or a luminescent solar concentrator. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/108861 |
| CURRENT CPC | Organic electric solid-state devices H10K 30/30 (20230201) Original (OR) Class H10K 30/82 (20230201) H10K 30/87 (20230201) H10K 85/6572 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210014 | Amiri |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pedram Khalili Amiri (Wilmette, Illinois) |
| ABSTRACT | A voltage-controlled magnetic anisotropy (VCMA) magnetic tunnel junction (MTJ) device includes a bottom electrode, a bottom CoFeB fixed layer disposed above and in electrical communication with the bottom electrode, a MgO layer disposed above the bottom CoFeB fixed layer, a top CoFeB free layer disposed above the MgO layer, a Mo capping layer disposed above the top CoFeB free layer, and a top electrode disposed above and in electrical communication with the Mo capping layer. A magnetization state of the top CoFeB free layer is switchable between an original state and an opposite state by applying a switching voltage across the MTJ device for a switching duration corresponding to a half period of a magnetic moment precession of the top CoFeB free layer. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068173 |
| CURRENT CPC | Static Stores G11C 11/161 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3286 (20130101) Electronic Memory Devices H10B 61/00 (20230201) Electric solid-state devices not otherwise provided for H10N 50/01 (20230201) H10N 50/10 (20230201) Original (OR) Class H10N 50/85 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230200656 | Ghosh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kunal Ghosh (San Francisco, California); Laurie D. Burns (Menlo Park, California); Abbas El Gamal (Palo Alto, California); Mark J. Schnitzer (Palo Alto, California); Eric Cocker (Palo Alto, California); Tatt Wei Ho (Stanford, California) |
| ABSTRACT | Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 μm resolution for an image of the field of view. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896461 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Original (OR) Class A61B 90/20 (20160201) A61B 2090/306 (20160201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0087 (20130101) G02B 21/0008 (20130101) G02B 21/008 (20130101) G02B 21/16 (20130101) G02B 21/36 (20130101) G02B 21/361 (20130101) G02B 21/362 (20130101) G02B 21/365 (20130101) G02B 27/141 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Pictorial Communication, e.g Television H04N 23/55 (20230101) H04N 23/56 (20230101) H04N 23/69 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201235 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); UChicago Argonne, LLC (Chicago, Illinois); Auburn University (Auburn, Alabama) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois); UChicago Argonne, LLC (Chicago, Illinois); Auburn University (Auburn, Alabama) |
| INVENTOR(S) | Youngchang Kim (Naperville, Illinois); Natalia Ivanovna Maltseva (Batavia, Illinois); Robert Jedrzejczak (Marengo, Illinois); Andrzej Joachimiak (Bolingbrook, Illinois); Jacek Wower (Auburn, Alabama); Glenn Randall (Chicago, Illinois) |
| ABSTRACT | Provided is a method of treating a disease caused by a nidovirus that encodes Nsp15, such as a coronavirus, an arterivirus, or a torovirus, in a subject in need thereof comprising administering a therapeutically effective amount of an active agent selected from 3′-uridylic acid, 5′-uridylic acid, citrate, methacycline, meclocycline sulfosalicylate, mitoxantrone, epirubicin hydrochloride, daunorubicin hydrochloride, sorafenib, sunitinib malate, primaquine diphosphate, closantel, isopropyl ester of N4-hydroxycytidine, GpU dinucleotide or derivatives thereof, and tipiracil or N-substituted derivatives thereof. Further provided are a method of inhibiting an Nsp15 endoribonuclease of a nidovirus that encodes Nsp15 and compounds of formulas (I′) and (II′). |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/926261 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/513 (20130101) A61K 31/7072 (20130101) Original (OR) Class A61K 31/7084 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201743 | RESTIVO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MICHAEL L. RESTIVO (AIKEN, South Carolina); MICHAEL R. POIRIER (EVANS, Georgia); FERNANDO F. FONDEUR (NORTH AUGUSTA, South Carolina); SAMUEL D. FINK (AIKEN, South Carolina) |
| ABSTRACT | Centrifugal contactors that can be used for mixing or separating materials are described. The contactors include a sensing system including a communications fiber within the shaft of the contactors and access ports providing access from the communications fiber to the mixing/separating zone of the contactor. The sensing system can be utilized during operation of the contactor and can provide for detailed and accurate on-line characterization of a protocol, as well as process control and system modification as necessary during operation. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/179602 |
| CURRENT CPC | Separation B01D 11/048 (20130101) Original (OR) Class B01D 11/0434 (20130101) B01D 11/0461 (20130101) B01D 11/0484 (20130101) Centrifuges B04B 1/02 (20130101) Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202840 | Flanders et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Twelve Benefit Corporation (Berkeley, California) |
| ASSIGNEE(S) | Twelve Benefit Corporation (Berkeley, California) |
| INVENTOR(S) | Nicholas H. Flanders (San Francisco, California); Kendra P. Kuhl (Oakland, California); Carter S. Haines (Berkeley, California); Luka Stevic (Novi Sad, Serbia); Gregory DiCosola (Redmond, Washington) |
| ABSTRACT | A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 18/052845 |
| CURRENT CPC | Separation B01D 53/326 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/382 (20130101) Original (OR) Class C01B 2203/042 (20130101) C01B 2203/062 (20130101) C01B 2203/0475 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 1/23 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202946 | Dagle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Vanessa Dagle (Richland, Washington); Robert A. Dagle (Richland, Washington) |
| ABSTRACT | Systems for preparing butenes are provided. The systems can include a reactor inlet coupled to both a reactor and at least one reactant reservoir; at least one of the reactant reservoirs containing one or both of an aldehyde and/or ethanol; a catalyst within the reactor, the catalyst comprising a metal component and an acidic support material; and a reactor outlet operationally configured to convey a butene-rich reaction product to a product reservoir. Methods for preparing butenes are also provided. The methods can include exposing one or both of ethanol and/or an aldehyde to a catalyst comprising a metal component and an acidic support to form a butene-rich product that comprises one or both of 1-butene and/or 2-butene. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116181 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/24 (20130101) B01J 8/1881 (20130101) B01J 21/08 (20130101) B01J 21/066 (20130101) B01J 23/72 (20130101) Acyclic or Carbocyclic Compounds C07C 1/22 (20130101) Original (OR) Class C07C 2521/06 (20130101) C07C 2521/08 (20130101) C07C 2523/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202950 | Marshall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois); FORGE NANO (Louisville, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher L. Marshall (Naperville, Illinois); Zheng Lu (Bolingbrook, Illinois); Jeffrey W. Elam (Elmhurst, Illinois); Christopher Nicholas (Evanston, Illinois); Paul T. Barger (Arlington Heights, Illinois); Martha Leigh Abrams (Chicago, Illinois); Arrelaine Dameron (Boulder, Colorado); Ryon W. Tracy (Westminster, Colorado) |
| ABSTRACT | Provided herein is an alkane dehydrogenation catalyst, a method of manufacturing an alkane dehydrogenation catalyst, and a method of converting alkanes to alkenes. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178490 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 21/063 (20130101) B01J 23/42 (20130101) B01J 23/70 (20130101) B01J 33/00 (20130101) B01J 35/0006 (20130101) B01J 35/023 (20130101) B01J 35/1014 (20130101) B01J 35/1019 (20130101) B01J 35/1038 (20130101) B01J 35/1042 (20130101) B01J 35/1061 (20130101) B01J 37/12 (20130101) B01J 37/18 (20130101) B01J 37/082 (20130101) B01J 37/0207 (20130101) B01J 37/0238 (20130101) B01J 37/0244 (20130101) Acyclic or Carbocyclic Compounds C07C 5/3337 (20130101) Original (OR) Class C07C 2521/04 (20130101) C07C 2521/06 (20130101) C07C 2523/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203212 | Hartmann-Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 3M INNOVATIVE PROPERTIES COMPANY (St. Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Claire Hartmann-Thompson (Lake Elmo, Minnesota); Mark J. Pellerite (Woodbury, Minnesota); Carl A. Laskowski (Minneapolis, Minnesota); John Christopher Thomas (St. Paul, Minnesota); Marina M. Kaplun (Woodbury, Minnesota) |
| ABSTRACT | Cationic polymers are provided that comprise monomeric units of Formula (V). (V) Each asterisk (*) indicates an attachment position to another monomeric unit; R is hydrogen or methyl; each R2 is each independently an alkyl, aryl, or a combination thereof; L is a linking group comprising an alkylene group; and +R3 is a cationic nitrogen-containing group free of any N—H bonds. Membranes formed from said cationic polymers, devices including such membranes, and methods of making such cationic polymers are also provided. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/756324 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/32 (20130101) C08F 8/42 (20130101) Original (OR) Class C08F 297/04 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2243 (20130101) C08J 2353/02 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/414 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203372 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenwen Lin (Willowbrook, Illinois); Duck Young Chung (Bolingbrook, Illinois); Mercouri G. Kanatzidis (Wilmette, Illinois) |
| ABSTRACT | Inorganic perovskites doped with oxygen atoms or fluorine atoms, methods for making the doped perovskites, and hard radiation detectors incorporating the doped perovskites as photoactive layers are provided. The doped perovskites utilize lead oxide, lead fluoride, or compounds that thermally decompose into lead oxide or lead fluoride as dopant atom sources. During the crystallization of a perovskite in the presence of the dopant atom sources, oxygen or fluoride atoms from the dopant source are incorporated into the perovskite crystal lattice. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/919825 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 21/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/34 (20130101) C01P 2002/54 (20130101) C01P 2002/72 (20130101) C01P 2006/40 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/665 (20130101) Original (OR) Class Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 11/02 (20130101) C30B 29/12 (20130101) Measurement of Nuclear or X-radiation G01T 1/2018 (20130101) G01T 1/2023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203461 | Bruce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of York (York, United Kingdom); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | The University of York (York, United Kingdom); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Neil Bruce (York, United Kingdom); Nicola Oates (York, United Kingdom); John Ralph (Madison, Wisconsin) |
| ABSTRACT | The present application relates to nucleic acids encoding polypeptides with β-etherase activity; polypeptides with β-etherase activity; vectors comprising said nucleic acids for the production of recombinant β-etherase; cells, for example microbial cells transformed with nucleic acids encoding β-etherase activity and vectors, including nucleic acids encoding β-etherases; a composition comprising β-etherases suitable for processing lignocellulose and a method that uses β-etherases or compositions comprising β-etherases in the processing of lignocellulose and related polysaccharides. |
| FILED | Saturday, January 09, 2021 |
| APPL NO | 17/791144 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) Original (OR) Class C12N 15/80 (20130101) Enzymes C12Y 303/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203682 | Yan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Delaware (Newark, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yushan Yan (Hockessin, Delaware); Junwu Xiao (Newark, Delaware); Alexandra Oliveria (Elkton, Maryland); Lan Wang (Newark, Delaware); Yun Zhao (Newark, Delaware); Teng Wang (Newark, Delaware); Junhua Wang (Newark, Delaware); Brian Setzler (Newark, Delaware) |
| ABSTRACT | Fluoride-containing nickel iron oxyhydroxide electrocatalysts for use as anodes in anion exchange membrane electrolyzers for generating hydrogen gas. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/923355 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 9/19 (20210101) C25B 11/032 (20210101) C25B 11/065 (20210101) C25B 11/081 (20210101) C25B 11/091 (20210101) Original (OR) Class C25B 13/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203684 | Budaragin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FCET, INC. (Alpharetta, Georgia); UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | FCET, INC. (Alpharetta, Georgia); UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Leonid V. Budaragin (Moscow, Russian Federation); Mark A. Deininger (Roswell, Georgia); Michael M. Pozvonkov (Cumming, Georgia); D. Morgan Spears, II (Atlanta, Georgia); Paul D. Fisher (Landis, North Carolina); Gerard M. Ludtka (Oak Ridge, Tennessee); Arvid E. Pasto (Sparks, Nevada) |
| ABSTRACT | Some embodiments of the present invention provide solid oxide cells and components thereof having a metal oxide electrolyte that exhibits enhanced ionic conductivity. Certain of those embodiments have two materials, at least one of which is a metal oxide, disposed so that at least some interfaces between the domains of the materials orient in a direction substantially parallel to the desired ionic conductivity. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/080905 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/628 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 9/19 (20210101) C25B 9/23 (20210101) C25B 13/04 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/40 (20130101) G01N 27/4073 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/122 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/004 (20130101) H01M 8/126 (20130101) H01M 8/0271 (20130101) H01M 8/1006 (20130101) H01M 8/1007 (20160201) H01M 8/1016 (20130101) H01M 8/1246 (20130101) H01M 8/1253 (20130101) H01M 2008/1293 (20130101) H01M 2300/0071 (20130101) H01M 2300/0074 (20130101) H01M 2300/0077 (20130101) H01M 2300/0091 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/50 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203697 | Hubbard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Lance Hubbard (Richland, Washington); Christina Arendt (Richland, Washington); Ryan Webster (Spokane Valley, Washington) |
| ABSTRACT | Disclosed herein are embodiments of a coating composition and a method of using the same for forming metal coatings on substrates. In particular embodiments, the coating composition comprises a deep eutectic solvent and/or an ionic liquid; a metal precursor; an alkaline salt; and an optional additive component. The coating composition and method embodiments disclosed herein provide durable, even, high-surface area coatings on various types of substrates and also can be used at low temperatures. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106700 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/54 (20130101) Original (OR) Class C25D 5/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204756 | Beer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | N. Reginald Beer (Pleasanton, California); Steven Bond (Livermore, California); Peter C. Haugen (Livermore, California); Jacob Trueblood (Dublin, California); Brian Matthew Wihl (Pleasanton, California) |
| ABSTRACT | A GPR system the implements a modified multistatic mode of operation is provided. The GPR is suitable for mounting on an unmanned aerial vehicle. The GPR system has radar transceivers. The GPR system transmits transmit signal serially via the transceivers. For each transceiver that transmits a transmit signal, the GPR system receives a return signal acquired by each transceiver except for a return signal for the transceiver that transmits the transmit signal. The GPR system outputs of matrix of return signals that includes a null value for the return signals of the transceivers that transmit. |
| FILED | Thursday, March 09, 2023 |
| APPL NO | 18/119478 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/40 (20130101) G01S 13/003 (20130101) G01S 13/87 (20130101) G01S 13/89 (20130101) G01S 13/0209 (20130101) G01S 13/885 (20130101) Original (OR) Class Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204820 | RAY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan James RAY (Tracy, California); Eyal FEIGENBAUM (Livermore, California) |
| ABSTRACT | The present disclosure relates to a system for producing a patterned nanostructured surface on a component from a pre-existing, nanostructured surface with a first spatial feature distribution on the component. The system makes use of a force application element configured to apply a force to the pre-existing, nanostructured surface, and a force application control subsystem. The force application control subsystem is configured to control elevational movement of the force application element along a first axis of movement into and out of contact with the pre-existing, nanostructured surface to apply a predetermined load to the pre-existing, nanostructured surface. The predetermined load is sufficient to modify the pre-existing, non-patterned nanostructured surface to create the patterned nanostructured surface. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561627 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204936 | Ravizza |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank Ravizza (Livermore, California) |
| ABSTRACT | Disclosed are monolithic optical systems using an aerogel molded around a mandrel. A method of manufacturing an optical system includes applying a reflective coating to at least a portion of a surface of a mandrel, placing the mandrel in a tank and subsequently filling the tank with aerogel to a predetermined depth below a top of the mandrel. The method includes adding a separation layer to the tank on top of the aerogel at the predetermined depth, catalyzing the separation layer into a solid, and adding aerogel on top of the separation layer filling the tank with aerogel above a height of the mandrel, and removing the aerogel and mandrel from the tank, drying the aerogel into a solid aerogel structure, catalyzing the reflective coating to bond the reflective coating with the aerogel, and removing the mandrel from the aerogel structure to produce the aerogel structure having a hollowed-out interior. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/565314 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00596 (20130101) B29D 11/00865 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0061 (20130101) Optical Elements, Systems, or Apparatus G02B 7/182 (20130101) G02B 17/0808 (20130101) G02B 23/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230205955 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Virginia Polytechnic Institute and State University (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiao Chen (Tracy, California); Can Huang (Livermore, California); Liang Min (Pleasanton, California); Charanraj Thimmisetty (Dublin, California); Charles Tong (Danville, California); Yijun Xu (Nanjing, China PRC); Lamine Mili (New Alexandria, Virginia) |
| ABSTRACT | Techniques, systems, and devices are described for providing a computational frame for estimating high-dimensional stochastic behaviors. In one exemplary aspect, a method for performing numerical estimation includes receiving a set of measurements of a stochastic behavior. The set of correlated measurements follows a non-standard probability distribution and is non-linearly correlated. Also, a non-linear relationship exists between a set of system variables that describes the stochastic behavior and a corresponding set of measurements. The method includes determining, based on the set of measurements, a numerical model of the stochastic behavior. The numerical model comprises a feature space comprising non-correlated features corresponding to the stochastic behavior. The non-correlated features have a dimensionality of M and the set of measurements has a dimensionality of N, M being smaller than N. The method includes generating a set of approximated system variables corresponding to the set of measurements based on the numerical model. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/108964 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/27 (20200101) Original (OR) Class G06F 2111/10 (20200101) Computer Systems Based on Specific Computational Models G06N 7/01 (20230101) G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230206105 | Spiropulu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Maria Spiropulu (Pasadena, California); Lautaro Narváez (Pasadena, California); Venkata Ramana Raju Valivarthi (Pasadena, California) |
| ABSTRACT | A synchronization system for synchronizing photons in a quantum teleportation network. The synchronization system includes a multiplexer combining a clock pulse with a signal photon (carrying a qubit) in an optical fiber, the optical fiber connecting a transmitter node (including the multiplexer) and a receiver node (comprising a demultiplexer). The signal photons have signal wavelengths red shifted as compared to clock wavelengths of the clock pulses. The clock pulses have an intensity below a threshold, such that Raman scattering of the clock pulses by the fiber (shifting the clock wavelengths into the signal wavelengths) is negligible. The receiver node comprises a demultiplexer demultiplexing the one of the signal photons and the one of the clock pulses; a first detector detecting the one of the signal photons; and a second detector detecting the one of the clock pulses. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/074112 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class Transmission H04B 10/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230207142 | Youchison et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis L. Youchison (Oak Ridge, Tennessee); Brian Williams (Camarillo, California) |
| ABSTRACT | A nuclear fuel element is provided. The nuclear fuel element includes a porous support. The porous support includes a ligament and defines a pore adjacent to the ligament. The ligament has an interior surface spaced from the pore. The interior surface defines a void. The porous support includes silicon carbide. The nuclear fuel element includes a nuclear fuel material disposed in the pore. The nuclear fuel material includes a moderator and tri-structural isotropic (TRISO) particles. Another nuclear fuel element is provided. The nuclear fuel element includes a porous support. The porous support includes a ligament and defines a pore adjacent to the ligament. The ligament has an interior surface spaced from the pore. The interior surface defines a void. The ligament includes the nuclear fuel material. The nuclear fuel element includes a facesheet overlying the porous support and defines a hole. The hole is in fluid communication with the void. The nuclear fuel material includes a nuclear fuel. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/118390 |
| CURRENT CPC | Nuclear Reactors G21C 3/044 (20130101) Original (OR) Class G21C 3/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230207226 | RAMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tesla, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Santhanam RAMAN (San Diego, California); James BORKENHAGEN (Spring Valley, California); Xiaomei XI (Carlsbad, California); Xiang-Rong YE (San Diego, California) |
| ABSTRACT | An energy storage device can include a cathode, an anode, and a separator between the cathode and the anode, where the anode and/or electrode includes an electrode film having a super-fibrillized binder material and carbon. The electrode film can have a reduced quantity of the binder material while maintaining desired mechanical and/or electrical properties. A process for fabricating the electrode film may include a fibrillization process using reduced speed and/or increased process pressure such that fibrillization of the binder material can be increased. The electrode film may include an electrical conductivity promoting additive to facilitate decreased equivalent series resistance performance. Increasing fibrillization of the binder material may facilitate formation of thinner electrode films, such as dry electrode films. |
| FILED | Wednesday, February 08, 2023 |
| APPL NO | 18/166404 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/06 (20130101) H01G 11/28 (20130101) H01G 11/38 (20130101) H01G 11/42 (20130101) Original (OR) Class H01G 11/50 (20130101) H01G 11/52 (20130101) H01G 11/86 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/043 (20130101) H01M 4/133 (20130101) H01M 4/0416 (20130101) H01M 4/587 (20130101) H01M 4/621 (20130101) H01M 4/625 (20130101) H01M 10/0525 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230207787 | Spoerke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik David Spoerke (Albuquerque, New Mexico); Martha Gross (Albuquerque, New Mexico); Stephen Percival (Albuquerque, New Mexico); Leo J. Small (Albuquerque, New Mexico) |
| ABSTRACT | The present invention is directed to the modification of sodium electrochemical interfaces to improve performance of sodium ion-conducting ceramics in a variety of electrochemical applications. Enhanced mating of the separator-sodium interface by means of engineered coatings or other surface modifications results in lower interfacial resistance and higher performance at increased current densities, enabling the effective operation of molten sodium batteries and other electrochemical technologies at low and high temperatures. |
| FILED | Monday, January 02, 2023 |
| APPL NO | 18/092373 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/48 (20130101) H01M 4/366 (20130101) H01M 4/381 (20130101) Original (OR) Class H01M 4/0402 (20130101) H01M 10/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210006 | Forrest et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan); Yongxi Li (Ann Arbor, Michigan) |
| ABSTRACT | Organic photovoltaic cells (OPVs) and their compositions are described herein. In one or more embodiments, the acceptor with an active layer of an OPV includes is a non-fullerene acceptor. Such non-fullerene acceptors may provide improved OPV performance characteristics such as improved power conversion efficiency, open circuit voltage, fill factor, short circuit current, and/or external quantum efficiency. One example of a non-fullerene acceptor is (4,4,10,10-tetrakis(4-hexylphenyl)-5,11-(2-ethylhexyloxy)-4,10-dihydro-dithienyl[1,2-b:4,5b′]benzodi-thiophene-2,8-diyl) bis(2-(3-oxo-2,3-dihydroinden-5,6-dichloro-1-ylidene) malononitrile. |
| FILED | Tuesday, February 21, 2023 |
| APPL NO | 18/171747 |
| CURRENT CPC | Heterocyclic Compounds C07D 495/22 (20130101) Organic electric solid-state devices H10K 30/30 (20230201) H10K 85/621 (20230201) H10K 85/6576 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230201013 | Hong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Solinas Medical Inc. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Hong (Santa Clara, California); Erik van der Burg (Los Gatos, California); Amy Lee (Sunnyvale, California) |
| ABSTRACT | A self-sealing tubular graft is provided for implantation within a patient's body that includes an elongate tubular body including first and second self-sealing cannulation regions and a loop region extending between the first and second cannulation regions. The loop region includes one or more reinforcement members attached to a first length of the loop region and extending at least partially around a circumference of the tubular body. For example, the reinforcement members may include one or more sinusoidal or zigzag members extending along the first length with alternating peaks and valleys extending at least partially around a circumference of the tubular body. Self-sealing patches are also provided that include one or more reinforcement members embedded within base material. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116197 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/06 (20130101) A61F 2/07 (20130101) A61F 2/82 (20130101) A61F 2/88 (20130101) A61F 2/89 (20130101) Original (OR) Class A61F 2/885 (20130101) A61F 2002/072 (20130101) A61F 2230/0069 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3655 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201901 | TAKATA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KEYSTONE TOWER SYSTEMS, INC. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosalind K. TAKATA (Denver, Colorado); Loren Daniel BRIDGERS (Golden, Colorado); Eric D. SMITH (Denver, Colorado) |
| ABSTRACT | Spiral forming devices, systems, and methods can be used to join edges of a of a stock material, in a curved configuration, along one or more joints to form tubular structures, such as conical and/or cylindrical structures (e.g., frusto-conical structures). A planar form of the stock material can be formed from a plurality planar sheets coupled to one another in an abutting relationship. By controlling relative orientation and shapes of the plurality of planar sheets forming the stock material and/or by controlling a position of a roll bender used to curve the planar form of the stock material into the curved configuration, the curved configuration of the stock material can be controlled through transitions between sheets to facilitate rolling the sheets to a desired diameter with a reduced likelihood of dimples or other errors and to facilitate fit up between adjacent sheets in the curved configuration. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/084368 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/185 (20130101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 31/027 (20130101) Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General E04H 12/08 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/728 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203569 | Kanavarioti |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Anastassia Kanavarioti (El Dorado Hills, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastassia Kanavarioti (El Dorado Hills, California) |
| ABSTRACT | Provided for herein is a method for detecting the presence of a nucleic acid target molecule in a biological sample. In certain aspects, the method comprises contacting a test sample that comprises (i) a biological sample comprising a nucleic acid target molecule and (ii) an osmylated single-stranded oligonucleotide probe comprising at least one pyrimidine residue covalently bonded to a substituted or unsubstituted Osmium tetroxide (OsO4)-2,2′-bypyridine group (OsBp group). |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/897743 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6832 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203667 | Hong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SOUTH DAKOTA BOARD OF REGENTS (Pierre, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haiping Hong (Rapid City, South Dakota); Rob Hrabe (Box Elder, South Dakota); Marius Ellingsen (Box Elder, South Dakota) |
| ABSTRACT | The present disclosure relates to anode compositions, methods of preparing the anode compositions via cold spray, and batteries having an anode comprising the anode compositions, a cathode, a separator, and an electrolyte. Preferably, the anode compositions comprise a metalloid and/or metal added in its elemental form. Preferably the batteries are lithium ion batteries. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 18/048753 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 24/04 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/386 (20130101) H01M 10/054 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230207852 | Jiang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Energao, Inc. (Makanda, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rong Jiang (Makanda, Illinois) |
| ABSTRACT | Provided in this patent disclosure are a novel titanium redox flow battery having a nitrogen-enriched catalyst, and a binary redox flow battery comprised of one unit that converts electricity into chemical energy to be stored in electrolytes and a separate second unit that converts the chemical energy from electrolytes back into electricity. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/088262 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/96 (20130101) H01M 8/188 (20130101) Original (OR) Class H01M 2004/8694 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230209437 | Mody et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | A10 Systems LLC (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | A10 Systems LLC (Chelmsford, Massachusetts) |
| INVENTOR(S) | Apurva N. Mody (Chelmsford, Massachusetts); Bryan Crompton (Lowell, Massachusetts); Junaid Islam (San Jose, California); David Simpson (Springfield, Virginia); Dap Minh Tran (Lowell, Massachusetts) |
| ABSTRACT | One or more aspects of the present disclosure are directed to network optimization solutions provided as software agents (applications) executed on network nodes in a heterogenous multi-vendor environment to provide cross-layer network optimization and ensure availability of network resources to meet associated Quality of Experience (QoE) and Quality of Service (QoS). In one aspect, a network slicing engine is configured to receive at least one request from at least one network endpoint for access to the heterogeneous multi-vendor network for data transmission; receive information on state of operation of a plurality of communication links between the plurality of nodes; determine a set of data transmission routes for the request; assign a network slice for serving the request; determine, from the set of data transmission routes, an end-to-end route for the network slice; and send network traffic associated with the request using the network slice and over the end-to-end route. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/069157 |
| CURRENT CPC | Wireless Communication Networks H04W 16/02 (20130101) H04W 40/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230202527 | McManus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Kali McManus (Woodbridge, Virginia); Kristi Harmel (Colorado Springs, Colorado); Gregory Bennett (Colorado Springs, Colorado) |
| ABSTRACT | Examples are directed toward a system and method relating to mobile screening. For example, a mobile screening vehicle includes a passenger scanner that performs security scanning of a passenger on the mobile screening vehicle. The mobile screening vehicle also includes a verification system that verifies, consistent with the security scanning of passengers, that passengers on the mobile screening vehicle are approved to proceed to a secure area of a travel venue. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/110721 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 40/08 (20130101) B60W 60/00253 (20200201) B60W 2540/043 (20200201) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3438 (20130101) G01C 21/3484 (20130101) G01C 21/3617 (20130101) Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class G06F 21/44 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06315 (20130101) G06Q 50/26 (20130101) G06Q 50/30 (20130101) Image or Video Recognition or Understanding G06V 40/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202528 | McManus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Kali McManus (Woodbridge, Virginia); Kristi Harmel (Colorado Springs, Colorado); Gregory Bennett (Colorado Springs, Colorado) |
| ABSTRACT | Examples are directed toward a system and method relating to mobile screening. For example, a mobile screening vehicle includes a passenger scanner that performs security scanning of a passenger on the mobile screening vehicle. The mobile screening vehicle also includes a verification system that verifies, consistent with the security scanning of passengers, that passengers on the mobile screening vehicle are approved to proceed to a secure area of a travel venue. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/110733 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 40/08 (20130101) B60W 60/00253 (20200201) B60W 2540/043 (20200201) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3438 (20130101) G01C 21/3484 (20130101) G01C 21/3617 (20130101) Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class G06F 21/44 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06315 (20130101) G06Q 50/26 (20130101) G06Q 50/30 (20130101) Image or Video Recognition or Understanding G06V 40/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202943 | Brogden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Michael Brogden (Galloway, New Jersey); Kevin Pedersen (Atco, New Jersey); Ronald Krauss (Galloway, New Jersey) |
| ABSTRACT | Various embodiments of the present invention are directed towards a simulant and method relating to producing a simulant. For example, a simulant of a textured target threat includes a background material associated with a background attenuation, and a texture component(s) dispersed in the background material and associated with a component attenuation and a component characteristic. The component characteristic prevents the component attenuation of the texture component from being homogeneously dispersed throughout the background attenuation of the background material, to cause the simulant to mimic an aspect(s) of an X-ray signature of the textured target threat. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/109007 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/005 (20130101) C06B 21/0041 (20130101) C06B 21/0066 (20130101) C06B 45/02 (20130101) C06B 45/04 (20130101) C06B 45/06 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203372 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenwen Lin (Willowbrook, Illinois); Duck Young Chung (Bolingbrook, Illinois); Mercouri G. Kanatzidis (Wilmette, Illinois) |
| ABSTRACT | Inorganic perovskites doped with oxygen atoms or fluorine atoms, methods for making the doped perovskites, and hard radiation detectors incorporating the doped perovskites as photoactive layers are provided. The doped perovskites utilize lead oxide, lead fluoride, or compounds that thermally decompose into lead oxide or lead fluoride as dopant atom sources. During the crystallization of a perovskite in the presence of the dopant atom sources, oxygen or fluoride atoms from the dopant source are incorporated into the perovskite crystal lattice. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/919825 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 21/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/34 (20130101) C01P 2002/54 (20130101) C01P 2002/72 (20130101) C01P 2006/40 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/665 (20130101) Original (OR) Class Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 11/02 (20130101) C30B 29/12 (20130101) Measurement of Nuclear or X-radiation G01T 1/2018 (20130101) G01T 1/2023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230204559 | Brogden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Goverment of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Michael C. Brogden (Galloway, New Jersey); Kevin Pedersen (Mays Landing, New Jersey); Ronald Krauss (Galloway, New Jersey) |
| ABSTRACT | Various embodiments of the present invention are directed towards a simulant and method relating to producing a simulant. For example, a simulant of a textured target threat includes a background material associated with a background attenuation, and a texture component(s) dispersed in the background material and associated with a component attenuation and a component characteristic. The component characteristic prevents the component attenuation of the texture component from being homogeneously dispersed throughout the background attenuation of the background material, to cause the simulant to mimic an aspect(s) of an X-ray signature of the textured target threat. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/109055 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/227 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230201763 | Graf |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Graf (Houston, Texas) |
| ABSTRACT | Concentration of oxygen gas with electrochemical stacks arranged in series gas flow. A system includes a plurality of electrochemical stacks for extracting oxygen from an input gas, wherein the plurality of electrochemical stacks outputs oxygen gas and oxygen-reduced gas. The system includes a heat exchanger in fluid communication with the plurality of electrochemical stacks, wherein the heat exchanger consumes the input gas and the oxygen-reduced gas, and wherein the heat exchanger transfers heat from the oxygen-reduced gas to the input gas. The system includes a mechanical blower for driving the input gas into the heat exchanger. The system is such that the plurality of electrochemical stacks are organized in series gas flow. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 18/000703 |
| CURRENT CPC | Separation B01D 53/326 (20130101) Original (OR) Class B01D 63/084 (20130101) B01D 2256/12 (20130101) B01D 2313/221 (20220801) B01D 2313/243 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230202263 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | John Charles Gray (Merritt Island, Florida); Daniel Jay Menard (Gilbert, Arizona); Mary Eileen Beckman (West Chester, Pennsylvania) |
| ABSTRACT | A passenger cabin air distribution system includes a ventilation system and an ejector-diffuser. The ventilation system is operable to provide a conditioned air. The ejector-diffuser is positioned to receive a flow of the conditioned air from the ventilation system. The ejector-diffuser includes an induction unit and a diffuser section. The induction unit includes a secondary inlet in communication with a cabin air from a passenger cabin and is configured to mix the flow of the conditioned air with an induced flow of the cabin air into a mixed air. The diffuser section includes a discharge to eject the mixed air to the passenger cabin. The diffuser section is shaped to provide for efficient mixing with low backpressure in order to maintain the low motive pressure in the nozzle. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152308 |
| CURRENT CPC | Arrangements of Heating, Cooling, Ventilating or Other Air-treating Devices Specially Adapted for Passenger or Goods Spaces of Vehicles B60H 1/3407 (20130101) Original (OR) Class Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/36 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 13/00 (20130101) B64D 13/06 (20130101) B64D 2013/003 (20130101) Cosmonautics; Vehicles or Equipment Therefor B64G 1/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203640 | Nichols et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John R. Nichols (Columbia, Maryland); Mihaela Ballarotto (Columbia, Maryland); Sungshan C. Chiang (Ellicott City, Maryland); Christian W. Drabenstadt (Savage, Maryland); Kathleen E. Ortel (Glenwood, Maryland); Curt A. Walsh (New Market, Maryland) |
| ABSTRACT | Effusion cells suitable for testing the outgassing of samples, such as flight components, during various temperatures are provided. The effusion cells include an enclosure structure including a loading door (LD) having a LD-open state and a LD-closed state, a trapdoor (TD) having a TD-open state and a TD-closed state, and an outgassing orifice. The enclosure structure defines an internal compartment when the LD is in the LD-closed state and the TD is in the TD-closed state, and wherein the outgassing orifice connects the internal compartment to an external environment, such as an interior portion of a vacuum chamber in which the effusion cell may be placed during operation. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 17/973887 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/243 (20130101) Original (OR) Class C23C 16/455 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230206107 | Carroll et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Streamline Automation LLC (Huntsville, Alabama); Wake Forest University (Winston Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Carroll (Winston Salem, North Carolina); Alton J. Reich (Huntsville, Alabama); Roberto Di Salvo (Cincinnati, Ohio) |
| ABSTRACT | A method for monitoring the state of a qubit device comprising a chiral nanocrystal includes measuring a voltage, a current, or a magnetic field of the nanocrystal; assigning the nanocrystal a superposition state if the measured voltage, current, or magnetic field is less than a superposition threshold; and assigning a base state value of the nanocrystal if the measured voltage is greater than a base state threshold. The measured voltage, current, or magnetic field corresponds to a clockwise or counter clockwise flow of electrons around the nanocrystal. |
| FILED | Monday, January 16, 2023 |
| APPL NO | 18/097328 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 29/423 (20130101) H01L 29/66977 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230209437 | Mody et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | A10 Systems LLC (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | A10 Systems LLC (Chelmsford, Massachusetts) |
| INVENTOR(S) | Apurva N. Mody (Chelmsford, Massachusetts); Bryan Crompton (Lowell, Massachusetts); Junaid Islam (San Jose, California); David Simpson (Springfield, Virginia); Dap Minh Tran (Lowell, Massachusetts) |
| ABSTRACT | One or more aspects of the present disclosure are directed to network optimization solutions provided as software agents (applications) executed on network nodes in a heterogenous multi-vendor environment to provide cross-layer network optimization and ensure availability of network resources to meet associated Quality of Experience (QoE) and Quality of Service (QoS). In one aspect, a network slicing engine is configured to receive at least one request from at least one network endpoint for access to the heterogeneous multi-vendor network for data transmission; receive information on state of operation of a plurality of communication links between the plurality of nodes; determine a set of data transmission routes for the request; assign a network slice for serving the request; determine, from the set of data transmission routes, an end-to-end route for the network slice; and send network traffic associated with the request using the network slice and over the end-to-end route. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/069157 |
| CURRENT CPC | Wireless Communication Networks H04W 16/02 (20130101) H04W 40/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230200323 | Hankoua et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bertrand B. Hankoua (Dover, Delaware); Ayalew Ligaba Osena (Greensboro, North Carolina) |
| ASSIGNEE(S) | Delaware State University (Dover, Delaware) |
| INVENTOR(S) | Bertrand B. Hankoua (Dover, Delaware); Ayalew Ligaba Osena (Greensboro, North Carolina) |
| ABSTRACT | The present invention provides a longitudinally split immature tiller separated from a rhizome (LSITR), a cluster of multiple in vitro shoots (CMIT), a cluster of stem segments containing shoot primordia (CSSSP) and an in vitro tiller of Miscanthus×giganteus (Giant miscanthus), and their uses in propagating Miscanthus×giganteus (Giant miscanthus). |
| FILED | Tuesday, February 21, 2023 |
| APPL NO | 18/112271 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 20/00 (20180201) New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 4/005 (20130101) Original (OR) Class A01H 5/12 (20130101) A01H 6/46 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201275 | ALTIER |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Craig ALTIER (Freeville, New York) |
| ABSTRACT | The present disclosure is directed to genetically modified bacteria that produce a diffusible signal factor (DSF). The disclosure also provides methods for treating or preventing Salmonella infection/invasion in a subject. The disclosure further provides vectors and compositions for carrying out the methods disclosed herein. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/915780 |
| CURRENT CPC | Fodder A23K 10/16 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/52 (20130101) C12N 15/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230207852 | Jiang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Energao, Inc. (Makanda, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rong Jiang (Makanda, Illinois) |
| ABSTRACT | Provided in this patent disclosure are a novel titanium redox flow battery having a nitrogen-enriched catalyst, and a binary redox flow battery comprised of one unit that converts electricity into chemical energy to be stored in electrolytes and a separate second unit that converts the chemical energy from electrolytes back into electricity. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/088262 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/96 (20130101) H01M 8/188 (20130101) Original (OR) Class H01M 2004/8694 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230201882 | Moran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Charles Moran (Crofton, Maryland); Marlon Guy Wells (Fort Washington, Maryland) |
| ABSTRACT | This disclosure relates to systems and methods of integrated on-demand labeling of item containers. In particular, this disclosure relates systems and methods for automatically creating and using placards to label, track, and organize item containers and items. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178344 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/14 (20130101) Original (OR) Class B07C 3/18 (20130101) B07C 3/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230203846 | Tartal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Albert Tartal (Baltimore, Maryland); Gabriel Michael Yessin (Baltimore, Maryland) |
| ABSTRACT | A lock can include a motor assembly, a gear assembly, and an unlocking assembly. The motor assembly can include a motor and a drive shaft. The gear assembly can include a cam, a pinion gear, and a pinion. The pinion gear can include a plurality of teeth disposed along only a portion of a perimeter of the pinion gear. The pinion gear can be configured to engage the pinion. The pinion can be configured to translate laterally to release a biasing member to unlock a door of a container. |
| FILED | Tuesday, February 14, 2023 |
| APPL NO | 18/169082 |
| CURRENT CPC | Household or Table Equipment A47G 29/20 (20130101) A47G 29/141 (20130101) A47G 2029/146 (20130101) A47G 2029/149 (20130101) Locks; Accessories Therefor; Handcuffs E05B 47/0012 (20130101) E05B 47/0603 (20130101) Original (OR) Class E05B 65/06 (20130101) E05B 2047/002 (20130101) E05B 2047/0017 (20130101) E05B 2047/0021 (20130101) E05B 2047/0084 (20130101) E05B 2047/0095 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 9/00563 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230206165 | Luckay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Luckay (Washington, District of Columbia); Robert E. Dixon, JR. (Washington, District of Columbia); Gregory Cooil (Washington, District of Columbia) |
| ABSTRACT | Methods and systems for autonomous item delivery and/or pick up are provided. IN some aspects, a mothership travels along an item route. One or more autonomous delivery vehicles may be dispatched from the mothership as the mothership progresses along the route. Each of the autonomous delivery vehicles may deliver and/or pick-up one or more items at one or more item locations. In addition, as the mothership progresses along its route, it may also stop to facilitate the manual delivery and/or pick-up of additional items via a human operator. Upon completing their delivery and/or pick up tasks, the autonomous delivery vehicles return to the mothership, either at the point at which they dispatched from the mothership, or at a different location along the item delivery route. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169539 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 80/86 (20230101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/343 (20130101) G01C 21/3469 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0027 (20130101) G05D 1/0088 (20130101) G05D 1/104 (20130101) G05D 1/0217 (20130101) G05D 2201/0213 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0832 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230200734 | Majerus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steve JA Majerus (University Heights, Ohio); Jeremy Dunning (Cleveland Heights, Ohio); Katherine M. Bogie (Cleveland, Ohio); Joseph A. Potkay (Plymouth, Michigan) |
| ABSTRACT | A sensor apparatus includes at least one substrate layer of an elastically deformable material, the substrate layer extending longitudinally between spaced apart ends thereof. A conductive layer is attached to and extends longitudinally between the spaced apart ends of the at least one substrate layer. The conductive layer includes an electrically conductive material adapted to form a strain gauge having an electrical resistance that varies based on deformation of the conductive layer in at least one direction. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/108808 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/026 (20130101) A61B 5/683 (20130101) Original (OR) Class A61B 5/02141 (20130101) A61B 5/02444 (20130101) A61B 5/6876 (20130101) A61B 2562/12 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 9/06 (20130101) G01L 9/0052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230201211 | SHAPIRO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul S. SHAPIRO (Baltimore, Maryland); Alexander D. MACKERELL, JR. (Baltimore, Maryland); Jeffrey D. HASDAY (Timonium, Maryland) |
| ABSTRACT | Compounds that inhibit p38α MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169785 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/54 (20130101) A61K 31/5375 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) A61P 29/00 (20180101) A61P 31/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 20230209845 | LUNT, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Royal LUNT, III (Williamston, Michigan); Christopher HERRERA (Haslett, Michigan); Chenchen YANG (Holt, Michigan); Aria VAHDANI (East Lansing, Michigan); Babak BORHAN (Okemos, Michigan) |
| ABSTRACT | A solar panel includes a substrate and a photoactive material. The photoactive material includes an ion and a counterion. An absolute magnitude of a binding energy between the ion and the counterion is less than or equal to about 6.5. A majority of available hydrogen sites on the counterion may be halogenated. A water contact angle of the photoactive material may be greater than or equal to about 65°. The solar panel may be a photovoltaic or a luminescent solar concentrator. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/108861 |
| CURRENT CPC | Organic electric solid-state devices H10K 30/30 (20230201) Original (OR) Class H10K 30/82 (20230201) H10K 30/87 (20230201) H10K 85/6572 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20230207523 | Chainer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (ARMONK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy J. Chainer (Putnam Valley, New York); Mark D. Schultz (Ossining, New York); Russell A. Budd (North Salem, New York); Todd Edward Takken (Brewster, New York); Matthew Doyle (Chatfield, Minnesota) |
| ABSTRACT | An integrated circuit package provides a high bandwidth interconnect between wafers using a very high density interconnect using a silicon bridge or a multi-layer flex between wafers. In some embodiments, more than one wafer may be mounted and connected with a rigid silicon bridge onto a common substrate. This common substrate can be matched, with respect to their coefficients of thermal expansion (CTE), to the silicon wafer. The CTE matched substrate can reduce the thermal mechanical stress on the wafers and the rigid silicon bridge interconnect. In some embodiments, a thinned silicon bridge is utilized to interconnect wafers which are mounted on separate glass substrates. The thinned bridge would allow for mechanical compliance between the wafers. In some embodiments, the wafers can be mounted onto separate glass substrates and attached with a fine pitch multi-layer flex structure which provides compliance between the wafers. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/564170 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/49822 (20130101) H01L 24/24 (20130101) H01L 25/0655 (20130101) Original (OR) Class H01L 2224/2512 (20130101) H01L 2224/24137 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, June 29, 2023.
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FUNDED BY
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Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230629.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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