FedInvent™ Patent Applications
Application Details for Thursday, July 06, 2023
This page was updated on Thursday, July 06, 2023 at 05:49 PM GMT
Department of Health and Human Services (HHS)
| US 20230210096 | Carlisle et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Diane L. Carlisle (Pittsburgh, Pennsylvania); Robert Max Friedlander (Pittsburgh, Pennsylvania); Abhishek Jauhari (Pittsburgh, Pennsylvania); Sergei Victorovich Baranov (Pittsburgh, Pennsylvania) |
| ABSTRACT | This document relates to non-human animal models (e.g., non-human mammalian models such as mouse models) for aging (e.g., neural aging). For example, non-human animal models having reduced or eliminated levels of aralkylamine N-acetyltransferase (AANAT) polypeptide expression are provided. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/800348 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Original (OR) Class A01K 2217/075 (20130101) A01K 2227/105 (20130101) A01K 2267/035 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210368 | Morgan et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Jessica I. W. Morgan (Mullica Hill, New Jersey); David H. Brainard (Merion Station, Pennsylvania); Robert F. Cooper (Philadelphia, Pennsylvania); William S. Tuten (Narberth, Pennsylvania) |
| ABSTRACT | A method for non-invasive assessment of photoreceptor function in a mammalian subject comprises exposing a subject's eye to a visible light stimulus to initiate an intrinsic reflectance response in one or a population of photoreceptors and capturing multiple images of photoreceptor's intrinsic reflectance response to the stimulus. Patterns of variability in the intrinsic reflectance response of a single photoreceptor or population of photoreceptors are useful in diagnosis and treatment monitoring of an ocular condition, disease, disorder or a response to treatment for said ocular condition, disease or disorder. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/162948 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) Original (OR) Class A61B 3/14 (20130101) A61B 3/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210371 | Larin et al. |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Kirill V. Larin (Friendswood, Texas); Manmohan Singh (Houston, Texas); Jiasong Li (Pearland, Texas); Zhaolong Han (Shanghai, China PRC); Michael D. Twa (Birmingham, Alabama) |
| ABSTRACT | Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/072838 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/18 (20130101) Original (OR) Class A61B 3/102 (20130101) A61B 3/165 (20130101) A61B 5/7246 (20130101) A61B 5/7289 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210455 | Deng |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Sophie Xiaohui Deng (Los Angeles, California) |
| ABSTRACT | The disclosure provides a comprehensive limbal stem cell deficiency diagnostic and staging system that combines observations of physiological parameters such as clinical presentation, central cornea basal cell density, central corneal epithelial thickness, and total corneal nerve fiber length. It has been discovered that the methodology disclosed herein can both accurately and objectively diagnose limbal stem cell deficiency as well as stage its severity. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/078403 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/1005 (20130101) A61B 5/4005 (20130101) A61B 5/4842 (20130101) Original (OR) Class A61B 5/7246 (20130101) A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210494 | Waag et al. |
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| APPLICANT(S) | Habico, Inc. (Honey Falls, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert C. Waag (Ocean City, New Jersey); Jeffrey P. Astheimer (Honey Falls, New York) |
| ABSTRACT | A system and method for capturing ultrasound signals from a hemispheric imaging region (e.g., by a stationary array of transducer elements arranged in the shape of a faceted hemisphere) and estimating scattering measurements that would be made by a virtual array in the opposite hemisphere (e.g., by a network of processors that receive and process the transmitted ultrasound signals in parallel) by forming an initial estimate of a medium variation for each of a plurality of subvolumes in the scattering object to form an estimated object, calculating residual scattering by using a difference between a scattering response calculated for the estimated object and measured ultrasound signals received from the scattering object, forming an initial three-dimensional image of the scattering object, and extrapolating a difference between the scattering response calculated for the estimated object and the measured ultrasound signals received from the scattering object. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/869443 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) A61B 8/14 (20130101) Original (OR) Class A61B 8/406 (20130101) A61B 8/483 (20130101) A61B 8/0825 (20130101) A61B 8/4281 (20130101) A61B 8/4483 (20130101) A61B 8/4494 (20130101) A61B 8/5207 (20130101) A61B 8/5269 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/8915 (20130101) G01S 15/8929 (20130101) G01S 15/8959 (20130101) G01S 15/8977 (20130101) G01S 15/8993 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210816 | Polyak et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| INVENTOR(S) | Stephen J. Polyak (Seattle, Washington); Shawn Herring (Seattle, Washington); Jessica Wagoner (Seattle, Washington); Judith White (Charlottesville, Virginia) |
| ABSTRACT | Methods for inhibiting or treating viral infection in a subject infected with a vims of the arenaviridae family with a therapeutic agent combination: (a) arbidol and aripiprazole; (b) arbidol and amodiaquine; (c) arbidol and sertraline; (d) arbidol, iprazole, and amodiaquine; (e) arbidol, aripiprazole, and sertraline; or (f) aripiprazole and amodiaquine; or pharmaceutically acceptable salts thereof. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/998800 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/47 (20130101) A61K 31/135 (20130101) A61K 31/496 (20130101) A61K 31/4045 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210817 | ANDERSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Celgene International II Sàrl (Couvet, Switzerland); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
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| INVENTOR(S) | Kenneth C. ANDERSON (Wellesley, Massachusetts); Dharminder CHAUHAN (Natick, Massachusetts); Michael A. PALLADINO (Olivenhain, California) |
| ABSTRACT | Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional and bortezomib treatment. Furthermore, combination treatment with two different proteosome inhibitors is shown to be synergistic for treating multiple myeloma. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890563 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/407 (20130101) Original (OR) Class A61K 31/454 (20130101) A61K 31/573 (20130101) A61K 31/704 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210829 | Blau et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Helen M. Blau (Stanford, California); Adelaida Rosa Palla (Stanford, California); Yu Xin Wang (Stanford, California) |
| ABSTRACT | The present disclosure provides compositions and methods based on the use of 15-PGDH as a therapeutic target in rejuvenation of aging non-skeletal muscle tissues and/or organs. The 15-PGDH inhibitor SW033291 administered intraperitoneally for 4 weeks resulted in restoration of follicular structure and re-establishment of the marginal zone in spleens of 25 month old mice. Treatment of 25 month old mice with SW033291 also reduced the levels of IL10, IL6, BTC, GM-CSF, IL 13 back to levels similar 0 to 4 month old mice. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/008750 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4365 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210840 | Silverman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Richard Bruce Silverman (Evanston, Illinois); Pathum Manjula Weerawarna (Evanston, Illinois) |
| ABSTRACT | Disclosed are substituted aminoquinoline and aminopyridine compounds and their use as bacterial nitric oxide synthase (bNOS) inhibitors. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject having or at risk for developing a disease or disorder that is associated with bNOS activity. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 18/047497 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 401/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210841 | Upadhyay |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
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| INVENTOR(S) | Geeta Upadhyay (Washington, District of Columbia) |
| ABSTRACT | The present disclosure relates to compounds that inhibit Ly6K. Also disclosed are methods of using such compounds to inhibit activity of Ly6K protein in a cell, to inhibit cell proliferation, to modulate expression of a gene in a cell, to reduce suppression of the immune response to cancer in a subject, to decrease tumorigenic growth of a cancer in a subject, and to treat or prevent in a subject a disorder mediated by Ly6K protein. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/924824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/473 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210849 | DAKSHANAMURTHY et al. |
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| APPLICANT(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| INVENTOR(S) | Sivanesan DAKSHANAMURTHY (Herndon, Virginia); Ivana PERAN (Washington, District of Columbia); Stephen W. BYERS (Takoma Park, Maryland); Shahin ASSEFNIA (Washington, District of Columbia) |
| ABSTRACT | Provided herein are compositions and methods for the treatment and prevention of cadherin-11 (CDH11) related diseases. The compositions include CDH11 inhibitors that are formulated for use in combination with chemotherapy and/or immunotherapy, to treat or prevent cancer, fibrosis, and autoimmune diseases. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/000752 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/343 (20130101) A61K 31/366 (20130101) A61K 31/405 (20130101) A61K 31/423 (20130101) A61K 31/473 (20130101) A61K 31/498 (20130101) Original (OR) Class A61K 31/4045 (20130101) A61K 31/4196 (20130101) A61K 31/4418 (20130101) A61K 31/4706 (20130101) A61K 31/7068 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/18 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210857 | Pergolizzi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Enalare Therapeutics Inc. (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph V. Pergolizzi (Naples, Florida); Frank Diana (Ocean City, New Jersey); Jiayi Chen (Short Hills, New Jersey); Devon E. Dodd (Lillington, North Carolina); Isaac Agyemang (Morrisville, North Carolina) |
| ABSTRACT | Disclosed in certain embodiments a parenteral formulation comprising a compound of Formula (I) as disclosed herein and a pharmaceutically acceptable excipient, wherein the formulation maintains at least 90% of the compound after accelerated storage conditions of 25° C. at 60% relative humidity for 2 weeks. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/088137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0019 (20130101) A61K 31/53 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210884 | Koeberl |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Dwight D. Koeberl (Durham, North Carolina) |
| ABSTRACT | The present invention relates, in general, to Pompe disease and, in particular, to methods of treating Pompe disease and to compounds/constructs suitable for use in such methods. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/146999 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Enzymes C12Y 302/0102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210892 | PUTNAM et al. |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | David PUTNAM (Ithaca, New York); Lawrence BONASSAR (Ithaca, New York); Zhexun SUN (Ithaca, New York) |
| ABSTRACT | The invention relates to methods of lubricating biological tissue, such as joints, bone, ocular tissue, nasal tissue, tendons, tendon capsule, and vaginal tissue, by contacting the biological tissue with an effective amount of a block copolymer lubricating composition which functions at least or better than lubricin. In particular embodiments, the method is used to treat osteoarthritis. In specific embodiments, the block copolymer has an ammonium-containing polymer block and a non-ionic hydrophilic polymer block, or the copolymer has a carboxylic acid-containing polymer block and a non-acid non-ionic hydrophilic polymer block. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856198 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/785 (20130101) Original (OR) Class A61K 31/795 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/286 (20200201) C08F 293/005 (20130101) C08F 2438/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210902 | REZVANI et al. |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
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| INVENTOR(S) | Katy REZVANI (Houston, Texas); Elizabeth SHPALL (Houston, Texas); Rafet BASAR (Houston, Texas); David MARIN COSTA (Houston, Texas); Nadima UPRETY (Houston, Texas); Emily ENSLEY (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure includes methods of producing viral-specific therapy (VST) cells specific for the SARS-CoV-2 virus and uses of the cells. The methods may utilized peptide mixtures and stimulation of mononuclear cells using particular cytokine cocktails. The cells may also be genetically modified to lack expression of one or more endogenous genes, including one or more genes that renders the cells more effective and/or able to withstand deleterious conditions, such as the presence of glucocorticoids. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/997148 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2501/998 (20130101) C12N 2501/2302 (20130101) C12N 2501/2304 (20130101) C12N 2501/2307 (20130101) C12N 2501/2315 (20130101) C12N 2501/2321 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210908 | VEISEH et al. |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Omid VEISEH (Houston, Texas); Amanda NASH (Houston, Texas); Bhagyashree Kishor BACHHAV (Houston, Texas); Carlos Alberto ORIGEL MARMOLEJO (Houston, Texas); Damon BERMAN (Houston, Texas); Christian SCHREIB (Houston, Texas); Laura SEGATORI (Houston, Texas); Alen TRUBELJA (Houston, Texas); Oleg A. IGOSHIN (Houston, Texas); Andrew D. HECHT (Houston, Texas) |
| ABSTRACT | The present disclosure provides expression constructs designed to provide for expression of therapeutic proteins from engineered cells. The engineered cells may be encapsulated into implantable elements that allow for the therapeutic protein to be released into from the capsule while protecting the cell from the immune system of a patient into which the capsule is implanted. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/904106 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/36 (20130101) Original (OR) Class A61K 38/00 (20130101) Peptides C07K 14/55 (20130101) C07K 14/7155 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0686 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) C12N 2830/001 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230210911 — METHODS AND MATERIALS FOR TREATING NON-MALIGNANT DISORDERS OR DISEASES WITH CORD BLOOD
| US 20230210911 | Szabolcs |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh- Of the commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Paul Szabolcs (Sewickley, Pennsylvania) |
| ABSTRACT | This document provides methods and materials for using umbilical cord blood to treat non-malignant disorders. For example, methods and materials for administering umbilical cord blood to a mammal (e.g., a human) via multiple (e.g., two or more) infusions to treat non-malignant diseases such as inherited disorders of metabolism, immunity, and/or hematopoiesis are provided. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 18/008482 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/51 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210926 | Buss et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marjorie T. Buss (Pasadena, California); Robert C. Hurt (Pasadena, California); Katie K. Wong (San Ramon, California); Mikhail G. Shapiro (Pasadena, California); Mengtong Duan (Pasadena, California); Arash Farhadi (Pasadena, California); Mei Yi You (Pasadena, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in dynamic non-destructive imaging. The non-destructive imaging can be nonlinear ultrasound imaging. There are provided, in some embodiments, nucleic acid compositions encoding gas vesicles (GVs) capable of producing nonlinear ultrasound contrast upon expression in a prokaryotic cell (e.g., a probiotic bacterial cell) or a eukaryotic cell (e.g., a therapeutic mammalian cell). |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066814 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/748 (20130101) Original (OR) Class A61K 49/22 (20130101) A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210929 | LI |
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| FUNDED BY |
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| APPLICANT(S) | JUN LI (MIAMI, Florida) |
| ASSIGNEE(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (MIAMI, Florida) |
| INVENTOR(S) | JUN LI (MIAMI, Florida) |
| ABSTRACT | The subject invention provides fungal extracts, fungal metabolites, pharmaceutical compositions comprising the fungal extracts, and/or fungal metabolites, methods of preparation, and therapeutic uses thereof. The subject invention also provides a bioactive agent and a composition comprising the bioactive agent, and therapeutic uses thereof. The subject invention further provides methods for treating, inhibiting and/or preventing malaria infection and transmission by using the fungal extracts, fungal metabolites, bioactive agents, and pharmaceutical compositions comprising the fungal extracts, fungal metabolites, and/or bioactive agent. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/088198 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) A61K 36/062 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210971 | Zhang |
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| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Huang-Ge Zhang (Louisville, Kentucky) |
| ABSTRACT | Provided are compositions and methods for using the same. In some embodiments, the compositions include an EPELN encapsulating and/or having associated therewith an active agent and a plasma membrane derived from a tumor and/or cancer cell coating the EPELN. In some embodiments, the active agent is a therapeutic agent or an immune response modifier, and in some embodiments the plasma membrane has one or more tumor-associated and/or cancer-associated antigens. Also provided are methods for using the compositions for treating tumors and/or cancers, inducing anti-tumor and/or anti-cancer immune responses, activating antigen-presenting cells, targeting CD11c dendritic cells, and preventing or reducing metastasis. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/889715 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0056 (20130101) A61K 9/1277 (20130101) A61K 31/05 (20130101) A61K 31/12 (20130101) A61K 31/203 (20130101) A61K 31/337 (20130101) A61K 31/353 (20130101) A61K 31/475 (20130101) A61K 31/513 (20130101) A61K 31/704 (20130101) A61K 33/243 (20190101) A61K 38/12 (20130101) A61K 39/0012 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/001102 (20180801) A61K 2039/55 (20130101) A61K 2039/812 (20180801) A61K 2039/6018 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211000 | Hansen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Blaze Bioscience, Inc. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stacey J. Hansen (Renton, Washington); Claudia Jochheim (Seattle, Washington); Dennis M. Miller (Woodinville, Washington); Natalie Winblade Nairn (Seattle, Washington); Julia E. Novak (Sequim, Washington); Mark R. Stroud (Seattle, Washington); Valorie R. Wiss (Moscow, Idaho); Kelly Byrnes-Blake (Sultan, Washington); Scott Presnell (Tacoma, Washington) |
| ABSTRACT | Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/888072 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/0071 (20130101) A61B 6/037 (20130101) A61B 6/481 (20130101) A61B 6/4057 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 47/65 (20170801) A61K 47/6415 (20170801) Original (OR) Class A61K 49/0056 (20130101) A61K 49/0058 (20130101) A61K 51/08 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) A61P 19/02 (20180101) Peptides C07K 14/4726 (20130101) C07K 14/43518 (20130101) C07K 14/43522 (20130101) C07K 16/244 (20130101) C07K 16/248 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211001 | Ahn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Green Ahn (Stanford, California); Caitlyn Miller (Standford, California); Carolyn R. Bertozzi (Menlo Park, California); Jennifer R. Cochran (Stanford, California); Steven Banik (Redwood City, California) |
| ABSTRACT | Provided are bifunctional molecules that include a first moiety that specifically binds a cell surface molecule, and a second moiety that specifically binds a lysosomal targeting molecule. In certain embodiments, the first moiety is a knottin peptide comprising an engineered loop that binds to the cell surface molecule. The bifunctional molecules find use, e.g., for targeted degradation of cell surface molecules (e.g., proteins) via the endosomal/lysosomal pathway. Also provided are compositions and kits that include the bifunctional molecules, as well as methods of using the bifunctional molecules. Methods of making bifunctional molecules are also provided. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 18/018238 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6415 (20170801) A61K 47/6425 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211004 | WANTUCH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paeton L. WANTUCH (Athens, Georgia); Jeremy A. DUKE (Athens, Georgia); Fikri Y. AVCI (Athens, Georgia) |
| ABSTRACT | The present disclosure provides peptides derived from CRM197 and Tetanus toxoid that can be used to generate an immune response in an individual. The present disclosure includes isolated peptides and multimers of isolated peptides. Also provided are compositions that include the isolated peptide or the multimer. Further provided are methods, including methods for increasing the antigenicity of a compound, such as an antigen, and methods for inducing an immune response in a subject |
| FILED | Sunday, November 22, 2020 |
| APPL NO | 17/778211 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/646 (20170801) Original (OR) Class A61K 47/6415 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211015 | Pu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical CenterCorporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical CenterCorporation (Boston, Massachusetts) |
| INVENTOR(S) | William T. Pu (Chestnut Hill, Massachusetts); Suya Wang (Brighton, Massachusetts) |
| ABSTRACT | Provided herein, in some aspects, are compositions and methods for treating Barth syndrome (BTHS) using human tafazzin gene therapy or enzyme replacement therapy. The present disclosure, in some aspects, provides compositions and methods (e.g., gene therapy or enzyme replacement therapy) for treating Barth syndrome (BTHS). It was demonstrated herein that certain human Tafazzin (hTAZ) isoforms and the full length protein, as well as nucleic acids encoding them, are effective in treating BTHS. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/799418 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1029 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211016 | Wagers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amy J. Wagers (Cambridge, Massachusetts); Mohammadsharif Tabebordbar (Cambridge, Massachusetts); Wei Leong Chew (Boston, Massachusetts); George M. Church (Brookline, Massachusetts) |
| ABSTRACT | Methods of editing target nucleic acids are provided using a guide RNA and a Cas9 protein to excise exons in a target gene and where the edited gene is expressed to produce a truncated polypeptide. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/145996 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211045 | Feins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Eric N. Feins (Boston, Massachusetts); Pedro J. del Nido (Lexington, Massachusetts); Nikolay V. Vasilyev (Brookline, Massachusetts); Haruo Yamauchi (Tokyo, Japan); Douglas P. Perrin (Boston, Massachusetts); Peter E. Hammer (Needham, Massachusetts); Veaceslav Arabagi (Cambridge, Massachusetts); Jeffrey M. Karp (Brookline, Massachusetts); Yuhan Lee (Cambridge, Massachusetts); Eoin D. O'Cearbhaill (Cambridge, Massachusetts) |
| ABSTRACT | An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901006 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/04 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211157 | Badran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bashar Badran (San Ramon, California); Mark George (Sullivans Island, South Carolina); Doe Jenkins (Johns Island, South Carolina); Daniel Cook (Charleston, South Carolina) |
| ABSTRACT | The present invention relates to systems for providing noninvasive cranial nerve stimulation and methods for using the same. The present invention administers therapy through electrodes that are noninvasively attached to one or more of a subject’s cranial nerve. The systems can be used to enhancing rehabilitation and recovery by improving neuroplasticity and coupling muscle training with feedback. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 18/000011 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/0472 (20130101) A61N 1/36003 (20130101) Original (OR) Class A61N 1/36031 (20170801) A61N 1/36034 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211187 | Degertekin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fahrettin Levent Degertekin (Atlanta, Georgia); Costas Arvanitis (Atlanta, Georgia) |
| ABSTRACT | Multifunctional ultrasound systems and methods for body section registration and mapping of microbubble dynamics. A system is provided that includes one or more micromachined ultrasonic transducer arrays (MUTAs) configured to capture a high-resolution image of at least a portion of a body section using ultrasound and monitor microbubble activity during ultrasound treatment. The system includes an image registration module configured to spatially register the high-resolution image with a reference image. The system includes electronics configured to control one or more of drive signal amplitude, frequency filtering, multiplexing, and DC bias voltage. The system can be configured to control ultrasound treatment based on the monitoring of the microbubble activity during treatment. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/007562 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4494 (20130101) A61B 8/5261 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/0039 (20130101) A61N 2007/0052 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0292 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/5202 (20130101) G01S 7/52038 (20130101) G01S 15/899 (20130101) G01S 15/8925 (20130101) G01S 15/8929 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212122 | Neamati et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nouri Neamati (Ann Arbor, Michigan); Ding Xue (Ann Arbor, Michigan); Yibin Xu (Ann Arbor, Michigan) |
| ABSTRACT | Mitochondrial targeting compounds for the treatment of cancer and other disorders associated with mitochondrial function, including diabetes, autoimmune diseases, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases and their preparation. The present invention is also directed to the pharmaceutical compositions and treatment methods, prodrugs based on those compounds and the use thereof. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/927094 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 311/21 (20130101) Heterocyclic Compounds C07D 211/96 (20130101) Original (OR) Class C07D 401/04 (20130101) C07D 401/06 (20130101) C07D 401/12 (20130101) C07D 413/04 (20130101) C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212123 | Larsen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott D. Larsen (South Lyon, Michigan); James A. Shayman (Ann Arbor, Michigan); Michael William Wilson (Ann Arbor, Michigan); Neil Moss (Ridgefield, Connecticut) |
| ABSTRACT | Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/920794 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 213/40 (20130101) C07D 213/61 (20130101) C07D 213/64 (20130101) Original (OR) Class C07D 213/65 (20130101) C07D 213/68 (20130101) C07D 401/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212143 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Chenglong Li (Gainesville, Florida); Xiaozhi Yang (Gainesville, Florida); Wei Zhou (Gaithersburg, Maryland) |
| ABSTRACT | A series of PRMT5 inhibitor compounds are described. The compounds are useful as PRMT5 inhibitor compounds and in the treatment of PRMT5 mediated diseases, disorders, and symptoms thereof. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 17/599505 |
| CURRENT CPC | Heterocyclic Compounds C07D 209/86 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) Original (OR) Class C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212171 | Scott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David A. SCOTT (Newton, Massachusetts); Thomas GERO (Stow, Massachusetts); Tyler BEYETT (Brookline, Massachusetts); David HEPPNER (Brookline, Massachusetts); Krista E. GIPSON (Medford, Massachusetts); Shih-Chung HUANG (Lexington, Massachusetts); Steve STROUD (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Scott (Newton, Massachusetts); Thomas Gero (Stow, Massachusetts); Tyler Beyett (Brookline, Massachusetts); David Heppner (Brookline, Massachusetts); Krista E. Gipson (Medford, Massachusetts); Shih-Chung Huang (Lexington, Massachusetts); Steve Stroud (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 18/000722 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 487/04 (20130101) Original (OR) Class C07D 495/04 (20130101) C07D 513/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212172 | Huston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Vermont and State Agricultural College (Burlington, Vermont); Saint Louis University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher D. Huston (Burlington, Vermont); Erin E. Stebbins (Burlington, Vermont); Marvin J. Meyers (Wentzville, Missouri); Edmund Oboh (St. Louis, Missouri); Tanner Schubert (St. Louis, Missouri) |
| ABSTRACT | Provided are compounds with the following structure: Formula (I), and methods of making and using same. The methods of using the compounds may be methods for treating or prophylaxis of a cryptosporidium infection. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 18/001148 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/14 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212195 | Movassaghi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Mohammad Movassaghi (Lincoln, Massachusetts); Chase Robert Olsson (La Jolla, California); Tony Z. Scott (Cambridge, Massachusetts); Jaime Cheah (Medford, Massachusetts); Joshua Nathaniel Payette (Hollis, New Hampshire) |
| ABSTRACT | The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/146294 |
| CURRENT CPC | Heterocyclic Compounds C07D 519/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212202 | Herzon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seth Herzon (New Haven, Connecticut); Ranjit Bindra (New Haven, Connecticut); Kingson Lin (New Haven, Connecticut) |
| ABSTRACT | Disclosed are nitrosourea and other compounds, pharmaceutical composition, and methods of treating cancers that are MGMT deficient regardless of their MMR status and particularly compounds, pharmaceutical compositions, and methods of treating cancers that are both MGMT and MMR deficient. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067497 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 275/68 (20130101) Heterocyclic Compounds C07D 207/46 (20130101) C07D 239/42 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/4816 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212203 | Schiffer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Celia A. Schiffer (Shrewsbery, Massachusetts); Akbar Ali (Westborough, Massachusetts); Nese Kurt-Yilmaz (Shrewsbury, Massachusetts); Linah N. Rusere (Hendersonville, North Carolina); Gordon J. Lockbaum (Worcester, Massachusetts); Mina Henes (Boxborough, Massachusetts) |
| ABSTRACT | The present application provides compounds and methods of treating viral infections, including viral infections caused by HIV or HTLV. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/074219 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6561 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212215 | MICALIZIO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Glenn C. MICALIZIO (Norwich, Vermont) |
| ABSTRACT | The present disclosure relates to polycyclic (e.g., tetracyclic) glucocorticoid receptor (GR) modulators, synthetic methods for preparing such GR modulators, and methods of using such GR modulators to treat a glucocorticoid-dependent condition, such as cancer or hypercortisolism. Exemplary compounds have quaternary centers at C9 and C13 in which the quaternary center at C9 projects a substituent on the opposite face of the tetracycle as the substituent at C13. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/923466 |
| CURRENT CPC | Steroids C07J 43/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212220 | Szeto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell Research Foundation, Inc. (Ithaca, New York) |
| ASSIGNEE(S) | Cornell Research Foundation, Inc. (Ithaca, New York) |
| INVENTOR(S) | Hazel H. Szeto (New York, New York); Shaoyi Liu (Palisades Park, New Jersey); Sunghee Cho (Scarsdale, New York) |
| ABSTRACT | The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880271 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/03 (20130101) A61K 38/06 (20130101) A61K 38/07 (20130101) A61K 38/08 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 5/101 (20130101) Original (OR) Class C07K 5/1008 (20130101) C07K 5/1016 (20130101) C07K 5/1019 (20130101) C07K 5/1024 (20130101) C07K 14/705 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212235 | PEI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dehua PEI (Columbus, Ohio) |
| ABSTRACT | The present disclosure provides modified looped proteins comprising at least one looped region, wherein the at least one looped region comprises a cell penetrating peptide (CPP). In some embodiments, the present disclosure provides polynucleotides encoding the modified looped proteins and methods for their production. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/790340 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/43595 (20130101) Original (OR) Class C07K 16/18 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/1077 (20130101) Enzymes C12Y 204/02001 (20130101) C12Y 301/03048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212263 | Kafri |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tal Kafri (Carrboro, North Carolina) |
| ABSTRACT | The present invention provides Factor IX fusion proteins with higher specific activity and a longer useful clotting function relative to wild type or non-modified Factor IX protein. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068376 |
| CURRENT CPC | Peptides C07K 14/745 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/025 (20130101) Original (OR) Class C12N 9/644 (20130101) C12N 15/8673 (20130101) Enzymes C12Y 304/21022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212274 | Chatila et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Talal Amine Chatila (Belmont, Massachusetts); Hani Harb (Brookline, Massachusetts) |
| ABSTRACT | Described herein are methods and compositions for treating asthma or an allergic disease. Aspects of the invention relate to administering to a subject an agent that targets the Wnt or Hippo Signaling pathway, or Growth-differentiation factor 15 (GDF15), either alone or in combination. In certain embodiments, the subject is further administered a Notch4 inhibitor. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/800837 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 16/22 (20130101) Original (OR) Class C07K 16/32 (20130101) C07K 2317/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212276 | Clauss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias Clauss (Indianapolis, Indiana); Irina Petrache (Indianapolis, Indiana) |
| ABSTRACT | The present invention provides methods for diagnosing a patient with emphysema, COPD of lung injury caused by tobacco use by detecting the levels of EMAP II in a sample. Disclosed herein are the hypervariable regions for a rat monoclonal antibody that binds to a form of EMAP II. This disclosure also includes a polypeptide sequence included in EMAP II that is the target for the binding of the antibody to its target protein. This epitope serves as the basis for a humanized antibody that can be used to treat patients that suffer from pathologies that exhibit elevated levels of EMAP II expression. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/097078 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 16/2866 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212282 | Otero Adrán et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York Society for the Relief of the Ruptured and Crippled, maintaining the Hospital for Special (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miguel Otero Adrán (New York, New York); Purva Singh (Plainsboro, New Jersey) |
| ABSTRACT | Methods and compositions for treating, inhibiting, and/or preventing the progression of osteoarthritis comprise compositions that blocks or inhibits the expression, induction, activity, or signaling of LRRC15 protein or the expression, transcription or activity of the LRRC15 gene and administering such compositions to a human subject having osteoarthritis and in need thereof. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 18/000010 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/141 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Peptides C07K 16/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212295 | FRENETTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul S. FRENETTE (Bronx, New York); Sandra PINHO (Bronx, New York); Qiaozhi WEI (Bronx, New York); Sung Kyun LEE (Bronx, New York) |
| ABSTRACT | Antibodies and antibody fragments that inhibit the activity of vascular cell adhesion molecule 1 (VCAM1) and/or macrophage erythroblast attacher (MAEA) are provided, along with formulations and kits comprising these antibodies and antibody fragments and the use of the disclosed compositions, formulations, and kits to treat cancers, sickle cell disease, and Polycythemia Vera. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/146951 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212509 | DIAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FUJIFILM Cellular Dynamics, Inc. (Madison, Wisconsin); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | FUJIFILM Cellular Dynamics, Inc. (Madison, Wisconsin); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Andrew DIAS (Madison, Wisconsin); Erich BERNDT (Madison, Wisconsin); Lucas CHASE (Madison, Wisconsin); Juan AMARAL (Bethesda, Maryland); Arvydas MAMINISHKIS (Bethesda, Maryland); Kapil BHARTI (Bethesda, Maryland) |
| ABSTRACT | Provided herein are methods of producing a distinct bilayer culture of retinal epithelial cells (RPE) with photoreceptor cells and/or photoreceptor precursor cells (PR/PRP). Further provided herein is a therapy comprising transplantation of the RPE and PR/PRP bilayer as well as methods for testing candidate drugs using the bilayer. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 18/000008 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/227 (20130101) A61L 27/3641 (20130101) A61L 2430/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0056 (20130101) C12N 5/062 (20130101) Original (OR) Class C12N 5/0621 (20130101) C12N 2533/40 (20130101) C12N 2533/50 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212510 | LABARGE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Mark LABARGE (Duarte, California); Michael TODHUNTER (Duarte, California) |
| ABSTRACT | Disclosed are methods of producing organoids in the absence of any exogenous extracellular matrix or in the presence of an exogenous extracellular matrix at a concentration lower than gelling concentration, using microcontainers sealed with a hydrogel lid as well as organoids produced by this technique. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/998011 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0631 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2531/00 (20130101) C12N 2533/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212512 | Martin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EpiVax Inc. (Providence, Rhode Island); Food and Drug Administration (Silver Spring, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Martin (Providence, Rhode Island); Amy S. Rosenberg (Silver Spring, Maryland) |
| ABSTRACT | The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprise a polypeptide comprising at least a portion of SEQ NOS: 1-14, fragments and/or variants thereof, as well as methods of producing and using the same. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893579 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212513 | Conway et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Ashlee J. Conway (Boston, Massachusetts); Tolulope O. Rosanwo (Boston, Massachusetts); Thomas E. Williamson (Boston, Massachusetts); Trista E. North (Newton Center, Massachusetts); George Q. Daley (Cambridge, Massachusetts) |
| ABSTRACT | The invention described herein is directed to compositions and methods for inducing red blood cell (RBC) differentiation. Additionally, provided herein are methods of treating a subject in need thereof by administering the induced RBC described herein. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 18/009192 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) A61K 31/727 (20130101) A61K 35/16 (20130101) A61K 35/545 (20130101) A61K 38/18 (20130101) A61K 38/28 (20130101) A61K 38/40 (20130101) A61K 38/202 (20130101) A61K 38/1816 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0641 (20130101) Original (OR) Class C12N 2500/25 (20130101) C12N 2501/14 (20130101) C12N 2501/39 (20130101) C12N 2501/91 (20130101) C12N 2501/125 (20130101) C12N 2501/2303 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212517 | Shah |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dhvanit I. Shah (Chestnut Hill, Massachusetts) |
| ABSTRACT | In some aspects and embodiments, the invention provides methods for making hematopoietic stem cells, including for HSCT. The method comprises providing a cell population comprising hemogenic endothelial (HE) or endothelial cells, and increasing activity or expression of DNA (cytosine-5-)-methyltransferase 3 beta (Dnmt3b) and/or GTPase IMAP Family Member 6 (Gimap6) in the HE and/or endothelial cells under conditions sufficient for stimulating formation of HSCs. |
| FILED | Tuesday, February 21, 2023 |
| APPL NO | 18/172199 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 2501/999 (20130101) C12N 2506/28 (20130101) C12N 2527/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212520 | KLEMKE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard KLEMKE (La Jolla, California); Huawei WANG (San Diego, California) |
| ABSTRACT | Provided herein are cytoplasts, compositions comprising cytoplasts, methods of using cytoplasts, and methods of treating a subject, such as providing benefits to a healthy or unhealthy subject, or treating or diagnosing a disease or condition in a subject. In some embodiments, methods of treating a subject include: administering to the subject a therapeutically effective amount of a composition comprising a cytoplast. Also, provided herein are compositions (e.g., pharmaceutical compositions) that include a cytoplast. Also, provided herein are kits comprising instructions for using the compositions or methods. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066612 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/208 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/10 (20130101) C12N 5/0646 (20130101) C12N 5/0667 (20130101) C12N 15/88 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212526 | AGUIRRE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Aitor AGUIRRE (Okemos, Michigan); Yonatan Raz ISRAELI (Okemos, Michigan) |
| ABSTRACT | A method for generating a heart organoid is provided. The method includes forming a cellular aggregate of pluripotent stem cells, activating Wnt signaling in the cellular aggregate to cause the cellular aggregate to differentiate into a three-dimensional cardiac mesoderm, and inhibiting the Wnt signaling in the cardiac mesoderm to form the heart organoid. The heart organoid includes myocardial tissue, endocardial tissue defining at least one chamber, and epicardial tissue disposed on at least an outer surface of the myocardial tissue. The heart organoid beats. Heart organoids prepared in accordance with the method are also provided. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 18/010946 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 5/0697 (20130101) Original (OR) Class C12N 2501/415 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212556 | DuVall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cell Microsystems, Inc. (Durham, North Carolina); The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacquelyn DuVall (Durham, North Carolina); Brandon Thompson (Durham, North Carolina); Peter Alan Sims (New York, New York); Jinzhou Yuan (Edgewater, New Jersey); Zhouzerui Liu (New York, New York); Dogukan Mizrak (Ann Arbor, Michigan); Steven C. Gebhart (Durham, North Carolina); Peter Glyn Boone (Durham, North Carolina) |
| ABSTRACT | Systems and methods for associating single cell imaging data with RNA transcriptomics. Single cells are isolated into microwells with a microbead having oligonucleotides conjugated on its surface. Each oligonucleotide includes a cell identifying optical barcode that is unique to that bead and binding sequence for RNA capture after cell lysis. The system is configured for loading single cells into the microarray and for flowing cell lysis buffers and other reagents into the microarray for performing RNA library sample preparation. The system is also configured for lowing optical hybridization probes that are complementary to the cell identifying optical barcodes and optically labeled onto the microwell array and for obtaining images of the microwells in response to the probes. The system and unique cell identifying optical barcodes and complementary optical hybridization probes facilitate a link between phenotypic imaging of cells resident on the microwell array with single cell whole transcriptome sequencing. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/622527 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 41/48 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class C12N 15/1093 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6813 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212557 | Lim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendell A. Lim (San Francisco, California); Scott M. Coyle (San Francisco, California); Russell M. Gordley (San Francisco, California); Kole T. Roybal (San Francisco, California) |
| ABSTRACT | The present disclosure provides synthetic modular polypeptide libraries and nucleic acids encoding such synthetic modular polypeptide libraries. Also provided are methods of making synthetic modular polypeptide libraries and nucleic acids encoding synthetic modular polypeptide libraries. Methods of screening a synthetic modular polypeptide library to identify a selected phenotype associated with a member of a synthetic modular polypeptide library are also provided where such methods fmd use in both in vitro and in vivo assays. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068499 |
| CURRENT CPC | Peptides C07K 14/7051 (20130101) C07K 2317/24 (20130101) C07K 2319/02 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212563 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Seth Lawler Shipman (Boston, Massachusetts); Jeffrey D. Macklis (Brookline, Massachusetts); Jeffrey Matthew Nivala (Allston, Massachusetts) |
| ABSTRACT | This invention provides methods of altering a cell including providing the cell with a nucleic acid sequence encoding a Cas1 protein and/or a Cas2 protein of a CRISPR adaptation system, providing the cell with a CRISPR array nucleic acid sequence including a leader sequence and at least one repeat sequence, wherein the cell expresses the Cas1 protein and/or the Cas2 protein and wherein the CRISPR array nucleic acid sequence is within genomic DNA of the cell or on a plasmid. Also provided are methods and systems for nucleic acid storage and in vivo molecular recordings of events into a cell. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717283 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/122 (20130101) Computer Systems Based on Specific Computational Models G06N 3/123 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212568 | GOLDMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. GOLDMAN (Webster, New York); John N. MARIANI (Rochester, New York) |
| ABSTRACT | The present disclosure is directed to methods of inducing rejuvenation in a population of adult glial progenitor cells, and methods of treating a subject having a myelin deficiency. The method of inducing rejuvenation in a population of adult glial progenitor cells, may comprise: administering, to the population of adult glial progenitor cells, one or more nucleic acid molecules encoding microRNAs, wherein administering suppresses the signal transducer and activator of transcription 3 (STAT3) signaling pathway; and/or administering microRNAs, wherein administering suppresses the E2F transcription factor 6 (E2F6) signaling pathway; and/or administering microRNAs, wherein administering suppresses the Myc-associated factor X (MAX) signaling pathway, wherein said one or more nucleic acid molecules are administered in an amount sufficient to induce rejuvenation in the population of adult glial progenitor cells. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/968984 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2320/35 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212577 | Burge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Christopher B. Burge (Belmont, Massachusetts); Ana Fiszbein (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are methods for inhibiting or activating the transcription of a gene of interest, or inhibiting or activating the transcription of specific mRNA isoforms of a gene by using antisense oligonucleotides and/or small molecules. Also described herein are methods for activating transcription from a promoter and increasing overall gene expression by creating of a new splice site in a gene of a cell. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/065086 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212608 | Daigle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Allen Institute (Seattle, Washington) |
| ASSIGNEE(S) | Allen Institute (Seattle, Washington) |
| INVENTOR(S) | Tanya Daigle (Lake Forest Park, Washington); Lucas T. Graybuck (Seattle, Washington); Edward Sebastian Lein (Mercer Island, Washington); Boaz P. Levi (Seattle, Washington); John K. Mich (Seattle, Washington); Adriana Estela Sedeño Cortés (Seattle, Washington); Bosiljka Tasic (Seattle, Washington); Jonathan Ting (Lake Forest Park, Washington); Miranda Walker (Ann Arbor, Michigan); Hongkui Zeng (Seattle, Washington) |
| ABSTRACT | Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in inhibitory neocortical GABAergic neurons including somatostatin GABAergic neurons, parvalbumin GABAergic neurons, vasointestinal peptide GABAergic neurons, Lamp5 GABAergic neurons, and in some instances astrocytes. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/000574 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0085 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2510/02 (20130101) C12N 2750/14141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212614 | Doudna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emmanuelle Charpentier (Berlin, Germany); The Regents of the University of California (Oakland, California); University of Vienna (Vienna, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Martin Jinek (Berkeley, California); Krzysztof Chylinski (Vienna, Austria); Emmanuelle Charpentier (Berlin, Germany) |
| ABSTRACT | The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/064011 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/4684 (20180501) Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/746 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/13 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/31 (20130101) C12N 2310/32 (20130101) C12N 2310/33 (20130101) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Enzymes C12Y 301/04 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02312 (20130101) H01L 33/0075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212626 | Avalos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Jose L. Avalos (Princeton, New Jersey); Jared E. Toettcher (Princeton, New Jersey); Evan M. Zhao (Clarence Center, New York); Makoto A. Lalwani (San Jose, California) |
| ABSTRACT | Disclosed is a technique for constructing optogenetic amplifier and inverter circuits utilizing transcriptional activator/repressor pairs, in which expression of the transcriptional activator or repressor, respectively, is controlled by light-controlled transcription factors. This system is demonstrated utilizing the quinic acid regulon system from Neurospora crassa, or Q System, a transcriptional activator/repressor system. This is also demonstrated utilizing the galactose regulon from Saccharomyces cerevisiae, or GAL System. Such optogenetic amplifier circuits enable multi-phase microbial fermentations, in which different light schedules are applied in each phase to dynamically control different metabolic pathways for the production of proteins, fuels or chemicals. The orthogonal nature of the Q and GAL systems enable the co-expression of amplifier and inverter circuits to simultaneously amplify and invert the response of light-controlled transcriptional controls over different sets of genes in the same cell. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/087169 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 9/0006 (20130101) C12N 9/88 (20130101) C12N 9/1022 (20130101) C12N 15/81 (20130101) C12N 15/635 (20130101) C12N 2529/10 (20130101) C12N 2800/102 (20130101) C12N 2830/002 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/56 (20130101) C12P 17/06 (20130101) Original (OR) Class Enzymes C12Y 101/01027 (20130101) C12Y 202/01006 (20130101) C12Y 401/01005 (20130101) C12Y 403/01023 (20130101) C12Y 403/01024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212644 | Streets et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHAN ZUCKERBERG BIOHUB, INC. (San Francisco, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Streets (Oakland, California); Nicolas Altemose (Oakland, California); Annie Maslan (Oakland, California) |
| ABSTRACT | The present disclosure provides materials and methods for co-determining the cellular location and nucleotide sequence of a DNA that is contacted by (or in close proximity to) a protein of interest in a single cell. Thus the present disclosure provides methods and materials wherein the cellular location of the DNA comprising a DNA-binding site or otherwise in close proximity to a protein of interest is coupled to the sequence of said DNA to provide contemporaneous imaging and sequence measurement of a protein-DNA interaction. |
| FILED | Tuesday, February 09, 2021 |
| APPL NO | 17/798506 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 2200/10 (20130101) B01L 2200/0647 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212649 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Jehyuk Lee (Allston, Massachusetts); Daniel Levner (Boston, Massachusetts); Michael Super (Lexington, Massachusetts) |
| ABSTRACT | Methods of analyzing nucleic acids of a cell are provided. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/064956 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Original (OR) Class C12Q 1/6837 (20130101) C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2458/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212658 | CAI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Long CAI (Pasadena, California); Eric LUBECK (Pasadena, California); Timur ZHIYENTAYEV (Pasadena, California); Ahmet COSKUN (Pasadena, California); Ting-Fang HE (Pasadena, California); Chang Ho SOHN (Pasadena, California); Sheel SHAH (Pasadena, California) |
| ABSTRACT | The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940356 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 2201/10 (20130101) G01N 2201/068 (20130101) Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212661 | ISMAGILOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. ISMAGILOV (Altadena, California); Bing SUN (Qingdao, Shandong, China PRC); Jesus RODRIGUEZ MANZANO (Pasadena, California); Eugenia KHOROSHEVA (South Pasadena, California); Matthew S. CURTIS (Pasadena, California) |
| ABSTRACT | The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/861077 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/6844 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212668 | Xie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoliang Sunney Xie (Lexington, Massachusetts); Katsuyki Shiroguchi (Arlington, Massachusetts); Peter A. Sims (Cambridge, Massachusetts); Tony Z. Jia (Cambridge, Massachusetts) |
| ABSTRACT | Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177496 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class C12N 2320/10 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212672 | SHENDURE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay SHENDURE (Seattle, Washington); Matthew SNYDER (Seattle, Washington); Martin KIRCHER (Seattle, Washington) |
| ABSTRACT | The present disclosure provides methods of determining one or more tissues and/or cell-types contributing to cell-free DNA (“cfDNA”) in a biological sample of a subject. In some embodiments, the present disclosure provides a method of identifying a disease or disorder in a subject as a function of one or more determined more tissues and/or cell-types contributing to cfDNA in a biological sample from the subject. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/805656 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6881 (20130101) Original (OR) Class C12Q 1/6883 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 20/30 (20190201) G16B 30/00 (20190201) G16B 40/00 (20190201) G16B 40/10 (20190201) G16B 45/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212693 | RABINOWITZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Natera, Inc. (San Carlos, California) |
| ASSIGNEE(S) | Natera, Inc. (San Carlos, California) |
| INVENTOR(S) | Matthew RABINOWITZ (San Francisco, California); Milena BANJEVIC (Los Altos Hills, California); Zachary DEMKO (San Francisco, California); David JOHNSON (San Francisco, California); Dusan KIJACIC (Los Altos Hills, California); Dimitri PETROV (Stanford, California); Joshua SWEETKIND-SINGER (San Jose, California); Jing XU (Jersey City, New Jersey) |
| ABSTRACT | Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/120873 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6855 (20130101) C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212698 | GREEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (TORONTO, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander GREEN (Boston, Massachusetts); Keith PARDEE (Toronto, Canada); Margot KARLIKOW (Toronto, Canada); Kaiyue WU (Tempe, Arizona); Masoud NOROUZI (Toronto, Canada) |
| ABSTRACT | Provided herein are methods and compositions for rapid, highly sensitive detection of SARS-CoV-2 in biological samples. In particular, provided herein is a rapid, low-cost method for detecting SARS-CoV-2 that provides reliable, visible test results and does not require PCR reagents, elaborate biosafety precautions, or sophisticated laboratory equipment. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/001395 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/6897 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213471 | XIAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yi XIAO (Cary, North Carolina); Yingzhu LIU (Wuhan, China PRC); Juan CANOURA (Hialeah Gardens, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Yi XIAO (Cary, North Carolina); Yingzhu LIU (Wuhan, China PRC); Juan CANOURA (Hialeah Gardens, Florida) |
| ABSTRACT | The subject invention provides methods for fabricating electrochemical aptamer-based (E-AB) sensors with enhanced sensitivity, signal-to-noise ratios, LOD, and improved stability and reproducibility. The subject invention also provides methods for aptamer immobilization on the surface of the electrode, which favors sufficient spacing between aptamers at the microscale to achieve optimal target recognition, folding, and signal transduction. The E-AB sensors of the subject invention provide superior sensing regardless of the sequence or structure of the bound aptamers or the physiochemical properties of the target. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/065118 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3276 (20130101) Original (OR) Class G01N 27/3277 (20130101) G01N 33/5308 (20130101) G01N 33/5438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213512 | Smith |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oklahoma Medical Research Foundation (Oklahoma City, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Smith (Oklahoma City, Oklahoma) |
| ABSTRACT | The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of Streptococcus pneumoniae infections. In particular, these antibodies may kill Streptococcus pneumoniae or limit the replication of Streptococcus pneumoniae. Also disclosed are improved methods for producing such monoclonal antibodies. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066582 |
| CURRENT CPC | Peptides C07K 16/1275 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/33 (20130101) C07K 2317/92 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56944 (20130101) G01N 2333/3156 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213533 | GOLDMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radoslav GOLDMAN (Reston, Virginia); Miloslav SANDA (Arlington, Virginia) |
| ABSTRACT | The instant disclosure provides methods of detecting N-glycopeptides in a sample by contacting the sample with one or more exoglycosidases and detecting the N-glycopeptides by mass spectrometry. Also provided are methods of detecting the presence or progression of a liver disease and treating said liver disease. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/749029 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213604 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Wang (St. Louis, Missouri); Qing Wang (St. Louis, Missouri) |
| ABSTRACT | A computing device for diffusion dictionary imaging (DDI) of microstructure and inflammation of a patient is provided. The DDI computing device is connected to other computing devices, such as a magnetic resonance imaging (MRI) scanner. The DDI computing device receives magnetic resonance (MR) signals from the MRI scanner. Once received, the DDI computing device records the one or more MR signals to a memory device. The DDI computing device computationally processes the one or more MR signals to reconstruct a diffusion MRI image using diffusion dictionary data. The MR signals include values that are used as input to algorithms of the DDI data to reconstruct the diffusion MRI image. A database is used to store DDI data, artificial intelligence (AI) data, diffusion dictionary data, and MR data. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/644433 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/414 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) G01R 33/56341 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230214541 | HANDZIC et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (TAMPA, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ISMET HANDZIC (LUTZ, Florida); KYLE B. REED (TAMPA, Florida) |
| ABSTRACT | In one embodiment, a kinetic shape is designed by determining an applied force to be applied to an object that is to incorporate the kinetic shape, determining a reactive force that is desired to be produced in response to the applied force, inputting the applied force and the reactive force into a kinetic shape equation, and solving the equation to obtain the kinetic shape. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902322 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0222 (20130101) A61H 1/0292 (20130101) A61H 3/00 (20130101) A61H 3/02 (20130101) A61H 3/0288 (20130101) A61H 2201/164 (20130101) A61H 2201/1284 (20130101) A61H 2201/1418 (20130101) A61H 2201/1623 (20130101) A61H 2201/1633 (20130101) Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 21/012 (20130101) A63B 21/068 (20130101) A63B 21/155 (20130101) A63B 22/16 (20130101) A63B 22/20 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 17/34 (20130101) Electric Digital Data Processing G06F 17/11 (20130101) G06F 30/00 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230215512 | Naughton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Brian Thomas Naughton (Mountain View, California); Colin Harvey (Mountain View, California); Ulrich Schlecht (Sunnyvale, California); Maureen Elizabeth Hillenmeyer (Palo Alto, California); Joe Horecka (Fremont, California) |
| ABSTRACT | Methods for identifying biosynthetic gene clusters that include genes for producing compounds that interact with specific target proteins are disclosed. Some methods relate to bioinformatics methods for identifying and/or prioritizing biosynthetic gene clusters. Related systems, components, and tools for the identification and expression of such gene clusters are also disclosed. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178471 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/79 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) G16B 20/00 (20190201) G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230210506 | Papadimitrakopoulos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Biorasis Inc. (Storrs, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fotios Papadimitrakopoulos (West Hartford, Connecticut); Allen Legassey (Mansfield, Connecticut); Joon-Sung Kim (Vernon, Connecticut); Jun Kondo (Hartford, Connecticut); Faquir Jain (Storrs, Connecticut) |
| ABSTRACT | Disclosed herein is a percutaneous catheter apparatus, comprising two nested needles; and an inner plunger; which is guided as a catheter to the tissue surrounding a hard implant to actuate and deploy a pair of sharp-tip needle-forceps that perform two concentric cuts, circularly spaced 90-degree apart from each other, to complete a 360 degree bore around the implant before squeezing to arrest and extract the implant, together with its surrounding tissue. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/928834 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/06 (20130101) Original (OR) Class A61B 17/3468 (20130101) A61B 2017/00349 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210841 | Upadhyay |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geeta Upadhyay (Washington, District of Columbia) |
| ABSTRACT | The present disclosure relates to compounds that inhibit Ly6K. Also disclosed are methods of using such compounds to inhibit activity of Ly6K protein in a cell, to inhibit cell proliferation, to modulate expression of a gene in a cell, to reduce suppression of the immune response to cancer in a subject, to decrease tumorigenic growth of a cancer in a subject, and to treat or prevent in a subject a disorder mediated by Ly6K protein. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/924824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/473 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210908 | VEISEH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Omid VEISEH (Houston, Texas); Amanda NASH (Houston, Texas); Bhagyashree Kishor BACHHAV (Houston, Texas); Carlos Alberto ORIGEL MARMOLEJO (Houston, Texas); Damon BERMAN (Houston, Texas); Christian SCHREIB (Houston, Texas); Laura SEGATORI (Houston, Texas); Alen TRUBELJA (Houston, Texas); Oleg A. IGOSHIN (Houston, Texas); Andrew D. HECHT (Houston, Texas) |
| ABSTRACT | The present disclosure provides expression constructs designed to provide for expression of therapeutic proteins from engineered cells. The engineered cells may be encapsulated into implantable elements that allow for the therapeutic protein to be released into from the capsule while protecting the cell from the immune system of a patient into which the capsule is implanted. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/904106 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/36 (20130101) Original (OR) Class A61K 38/00 (20130101) Peptides C07K 14/55 (20130101) C07K 14/7155 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0686 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) C12N 2830/001 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211059 | TREU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NxStage Medical, Inc. (Lawrence, Massachusetts) |
| ASSIGNEE(S) | NxStage Medical, Inc. (Lawrence, Massachusetts) |
| INVENTOR(S) | Dennis M. TREU (Castle Rock, Colorado); Jerome JAMES (Vestavia, Alabama); Jeffrey H. BURBANK (Manchester, Massachusetts); Daniel Joseph RUBERY, Jr. (Nashua, New Hampshire) |
| ABSTRACT | The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/920331 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1647 (20140204) Original (OR) Class A61M 1/3643 (20130101) A61M 1/36225 (20220501) A61M 1/362265 (20220501) A61M 2205/3331 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211162 | Leonard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Leonard (San Francisco, California); Edward Chang (San Francisco, California); William Schuerman (San Francisco, California); Bharath Chandrasekaran (Pittsburgh, Pennsylvania); Fernando Llanos Lucas (Austin, Texas) |
| ABSTRACT | Systems and methods for improving behavioral therapies encompassing therapies wherein a perceptual stimulus is administered to a subject or a motor behavior is performed by the subject. Such administration of perceptual stimuli or motor performance is paired with the delivery of vagus nerve stimulation to the subject. The vagus nerve stimulation is timed with the sensory stimulus administration or motor performance in a temporal alignment that maximizes neuroplasticity and performance. Systems for performance of the method and associated software are also disclosed |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/011117 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36025 (20130101) A61N 1/36053 (20130101) A61N 1/36092 (20130101) Original (OR) Class A61N 1/36139 (20130101) A61N 1/36157 (20130101) A61N 1/36171 (20130101) A61N 1/36175 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/02 (20130101) G09B 5/04 (20130101) G09B 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211460 | Kutscha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Arlington, Virginia) |
| ASSIGNEE(S) | The Boeing Company (Arlington, Virginia) |
| INVENTOR(S) | Eileen O. Kutscha (Seattle, Washington); Kay Y. Blohowiak (Issaquah, Washington) |
| ABSTRACT | There is provided a quantitative method for determining a level of a sanding surface preparation of a carbon fiber composite surface, prior to the carbon fiber composite surface undergoing a post-processing operation. The quantitative method includes fabricating a ladder panel of levels of sanding correlating to an amount of sanding of sanding surface preparation standards for a reference carbon fiber composite surface of reference carbon fiber composite structure(s); using surface analysis tools to create target values for quantifying the levels of sanding; measuring, with the surface analysis tools, sanding surface preparation location(s) on the carbon fiber composite surface of a test carbon fiber composite structure, to obtain test result measurement(s); comparing the test result measurement(s) to the levels, to obtain test result level(s); determining if the test result level(s) meet the target values; and determining whether the carbon fiber composite surface is acceptable to proceed with the post-processing operation. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/173016 |
| CURRENT CPC | Machines, Devices, or Processes for Grinding or Polishing; Dressing or Conditioning of Abrading Surfaces; Feeding of Grinding, Polishing, or Lapping Agents B24B 49/12 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3563 (20130101) G01N 2021/8411 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211861 | Gamache et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond Gamache (Salinas, California); William G. Szymczak (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed is a method and system to provide protection for maritime vessels from multiple threat types including shoulder launched rocket propelled threats, ballistic (howitzer), and larger scale missile systems. According to an exemplary embodiment, the protection system is based on the ballistic launch (from the protected vessel) of an explosive charge(s) aimed ˜5 meters away from the vessel and ˜1 meter beneath the waterline followed by detonation to enable the formation of a water wall. Through the formation of a water wall, incident threats can be initiated (piezo fuze), and passivated through dynamic interaction with the water formation. In addition, the upward velocity of the water wall can enable an upwards rotation of the incident threat changing the orientation of the warhead jet formation (for shape charge warheads) above the vessel. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/093753 |
| CURRENT CPC | Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 9/02 (20130101) Original (OR) Class Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 11/02 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/726 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211873 | Zigunov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fernando Zigunov (Tallahassee, Florida); Farrukh Alvi (Tallahassee, Florida) |
| ABSTRACT | Systems and methods are provided for experimentally determining optimized placement and operating conditions, e.g., amplitude, phase, or frequency, of active flow control actuators by executing an optimization routine to sequentially activate varying subsets of active flow control actuators of a plurality of active flow control actuators spatially distributed within a flow field, calculating a cost function of each of the subsets of sequentially activated active flow control actuators based on respective measurements of one or more parameters, e.g., integral variables or proxies to the integral variables, within the flow field by one or more sensors, and determining an optimal subset of active flow control actuators based on the respective cost functions of each of the subsets of sequentially activated active flow control actuators. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568677 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 21/00 (20130101) B64C 23/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211899 | Murphey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Opterus Research and Development, Inc. (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas W Murphey (Fort Collins, Colorado); Levi Nicholson (Wellington, Colorado) |
| ABSTRACT | A self-deployable array of panels includes a plurality of panels, each panel having a first compressed panel thickness state and a second expanded panel thickness state, and including a spring bias element biased to the second expanded panel thickness state. A plurality of locking hinges hingedly couple each of the panels to an adjoining panel. Each locking hinge is biased to an open position. A release of stored potential energy of both of the spring bias element biased to the second expanded panel thickness state, and the locking hinges biased to the open position causes the self-deployable array of panels to self-deploy from a folded stowed state. A single part offset locking hinge is also described. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068716 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/44 (20130101) B64G 1/443 (20130101) Original (OR) Class Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 30/10 (20141201) H02S 30/20 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212106 | Kelley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jude Aaron Kelley (Bolton, Massachusetts); Alla Ostrinskaya (Needham, Massachusetts); Eric Richard Morgan (Bolton, Massachusetts); Roderick Russell Kunz (Acton, Massachusetts) |
| ABSTRACT | The present disclosure provides a method of producing an aluminum salt, comprising reacting activated aluminum metal (Al(0)) with an anion donor. Also provided are aluminum salts prepared by the disclosed methods. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/978010 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/08 (20130101) C01B 25/36 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 7/58 (20130101) C01F 7/66 (20130101) Acyclic or Carbocyclic Compounds C07C 51/41 (20130101) Original (OR) Class C07C 55/07 (20130101) C07C 59/265 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212316 | Shelef |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miriam Shelef (Madison, Wisconsin) |
| ABSTRACT | Described herein are IgG epitope peptides that bind rheumatoid factors in rheumatoid arthritis (RA) and COVID-19. The IgG epitope peptides may be conjugated to a ligand, a detectable label, or a combination thereof. Also, the IgG epitope peptides are particularly useful in assays to detect antibodies in blood samples from subjects with RA risk factors, for example. The COVID-19 IgG epitope peptides are particularly useful in screening convalescent plasma. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/079188 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) A61P 31/14 (20180101) Peptides C07K 16/42 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212323 | Gilbert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luke Gilbert (San Francisco, California); Jonathan Weissman (San Francisco, California); James Nunez (San Francisco, California); Greg Pommier (San Francisco, California) |
| ABSTRACT | Provided herein are, inter alia, compositions and methods for modulating gene expression. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/999762 |
| CURRENT CPC | Peptides C07K 19/00 (20130101) Original (OR) Class C07K 2319/09 (20130101) C07K 2319/80 (20130101) C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212510 | LABARGE et al. |
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| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Mark LABARGE (Duarte, California); Michael TODHUNTER (Duarte, California) |
| ABSTRACT | Disclosed are methods of producing organoids in the absence of any exogenous extracellular matrix or in the presence of an exogenous extracellular matrix at a concentration lower than gelling concentration, using microcontainers sealed with a hydrogel lid as well as organoids produced by this technique. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/998011 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0631 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2531/00 (20130101) C12N 2533/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212661 | ISMAGILOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. ISMAGILOV (Altadena, California); Bing SUN (Qingdao, Shandong, China PRC); Jesus RODRIGUEZ MANZANO (Pasadena, California); Eugenia KHOROSHEVA (South Pasadena, California); Matthew S. CURTIS (Pasadena, California) |
| ABSTRACT | The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/861077 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/6844 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212682 | Shen-Gunther |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of The United States, as represented by The Secretary of The Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jane Shen-Gunther (San Antonio, Texas) |
| ABSTRACT | Disclosed herein are methods for molecularly characterizing cervical cell samples as being negative for intraepithelial lesion or malignancy (NILM), low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL). |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839803 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/708 (20130101) C12Q 1/6851 (20130101) C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212701 | Weitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Montana State University (Bozeman, Montana) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Montana State University (Bozeman, Montana) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Connie Chang Wilking (Bozeman, Montana); Dimitri A. Bikos (Bozeman, Montana); Emma Kate Loveday (Bozeman, Montana); Geoffrey K. Zath (Bozeman, Montana) |
| ABSTRACT | The present disclosure generally relates to systems and methods for detecting viruses, e.g., using microfluidic devices. Certain embodiments are generally directed to systems and methods that are able to detect pathogens such as viruses or bacteria by encapsulating a sample in droplets, and applying amplification reagents to the droplets able to amplify nucleic acids therein, e.g., using loop mediated isothermal amplification (LAMP) or other amplification techniques. In addition, some aspects are generally directed to identifying a species in a sample, e.g., at very low concentrations. In some cases, the sample may be broken into droplets, arid the droplets determined to determine the species. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/922284 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212743 | Kishore Kumar et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Deepan Kishore Kumar (San Jose, California); Nai-Chang Yeh (Pasadena, California) |
| ABSTRACT | A method of growing one or more graphene sheets on one or more regions of an optical fiber using plasma-enhanced chemical vapor deposition (PECVD) includes placing the optical fiber in a growth chamber, placing one or more carbon-containing precursors in the growth chamber, forming a reduced pressure in the growth chamber, and flowing methane gas and hydrogen gas into the growth chamber. The method also includes generating a plasma in the growth chamber, forming a gaseous carbon-containing precursor from the one or more carbon-containing precursors, exposing the one or more regions of the optical fiber to the methane gas, the hydrogen gas, the gaseous carbon-containing precursor, and the plasma, and forming the one or more graphene sheets on the one or more regions of the optical fiber. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/086996 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) Original (OR) Class C23C 16/511 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/32449 (20130101) H01J 37/32743 (20130101) H01J 37/32816 (20130101) H01J 2237/3321 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213638 | Dougherty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRC, Inc. (North Syracuse, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Dougherty (Liverpool, New York); David L. Weldum (Jamesville, New York) |
| ABSTRACT | A method of processing radar responses of a radar system characterized by a plurality of beam patterns, to determine if a given response corresponds to a reflective object. The method including, for a first beam pattern, identifying a response at an identified angle relative to a center of the first beam pattern. Then, for a second beam pattern overlapping the first beam pattern, determining if a measured response in the second beam pattern at an angle relative to the center of the second beam pattern that corresponds to the identified angle relative to the center of the first beam pattern is within a predetermined error threshold of an anticipated response calculated using the second beam pattern and the first beam pattern. If the measured response in the second beam pattern is not within the predetermined error threshold, the first response is eliminated from display and/or further tracking. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/565701 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/412 (20130101) G01S 7/414 (20130101) G01S 13/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230214661 | Perdikaris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paris Georgios Perdikaris (Philadelphia, Pennsylvania); George J. Pappas (Philadelphia, Pennsylvania); Jacob Hugh Seidman (Philadelphia, Pennsylvania); Georgios Kissas (Philadelphia, Pennsylvania) |
| ABSTRACT | Supervised operator learning is an emerging machine learning paradigm with applications to modeling the evolution maps of spatio-temporal dynamical systems and approximating general black-box relationships between functional data. We propose a novel operator learning method, LOCA (Learning Operators with Coupled Attention), motivated from the attention mechanism. The input functions are mapped to a finite set of features which are then averaged with attention weights that depend on the output query locations. By coupling these attention weights together with an integral transform, LOCA is able to explicitly learn correlations in the target output functions, enabling us to approximate nonlinear operators even when the number of output function measurements is very small. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/092888 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/09 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230215500 | Brewer |
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| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Devices and techniques for programmable atomic operator resource locking are described herein. A request for a programmable atomic operator (PAO) can be received at a memory controller that includes a programmable atomic unit (PAU). Here, the request includes an identifier for the PAO and a memory address. The memory addressed is processed to identify a lock value. A verification can be performed to determine that the lock value indicates that there is no lock corresponding to the memory address. Then, the lock value is set to indicate that there is now a lock corresponding to the memory address and the PAO is invoked based on the identifier for the PAO. In response to completion of the PAO, the lock value is set to indicate that there is no longer a lock corresponding to the memory address. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/117900 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/526 (20130101) G06F 12/0815 (20130101) G06F 12/0862 (20130101) G06F 12/0875 (20130101) G06F 13/1605 (20130101) G06F 13/1668 (20130101) G06F 2212/1024 (20130101) Static Stores G11C 16/08 (20130101) G11C 16/26 (20130101) G11C 16/102 (20130101) Original (OR) Class G11C 16/3459 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230215961 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Yong-Hang ZHANG (Scottsdale, Arizona); Xin QI (Tempe, Arizona); Zheng JU (Tempe, Arizona); Jia DING (Tempe, Arizona); Tyler MCCARTHY (Scottsdale, Arizona); Stephen SCHAEFER (Scottsdale, Arizona) |
| ABSTRACT | Contacts for solar cells and other optoelectronic devices are provided. Embodiments described herein take advantage of the surface Fermi level pinning effect to build an electrical field inside of a semiconductor to extract or inject carriers for solar cells, photodetectors, and light-emitting device applications. For example, n-type or p-type two-dimensional (2D) materials can be used in contact with an n-type semiconductor to form a “p-region” so that a p-n junction, or an i-n or n-n+ junction can be constructed. Similarly, n-type or p-type 2D materials can be used in contact with a p-type semiconductor to form an “n-region” so that an n-p junction, or an i-p or p-p+ junction can be constructed. These structures can provide sufficiently high electrical field inside the semiconductor to extract photogenerated carriers in solar cells and photodetectors or inject minority carriers for light-emitting devices. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/151341 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/186 (20130101) H01L 31/022425 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230216191 | Kalateh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Mahdi Honari Kalateh (Middleton, Wisconsin); Nader Behdad (Oregon, Wisconsin); John H. Booske (McFarland, Wisconsin) |
| ABSTRACT | A phase shift element includes an antenna, a first dielectric layer, a ground plane mounted to a first surface of the first dielectric layer, a reflecting circuit, and a single antenna-reflector line connected between the antenna and the reflecting circuit through the ground plane and the first dielectric layer. The antenna-reflector line is formed of a conducting material. The reflecting circuit is mounted to a second surface of the first dielectric layer. The first surface is opposite the second surface. The reflecting circuit is configured to reflect a signal received on the single antenna-reflector line from the antenna back to the antenna on the single antenna-reflector line. The reflecting circuit is further configured to be switchable between four different impedance levels that each provide a different phase shift when the signal is reflected by the reflecting circuit. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568015 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/48 (20130101) H01Q 3/36 (20130101) Original (OR) Class H01Q 9/0407 (20130101) H01Q 19/10 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230216193 | Kalateh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Mahdi Honari Kalateh (Middleton, Wisconsin); Nader Behdad (Oregon, Wisconsin); John H. Booske (McFarland, Wisconsin) |
| ABSTRACT | A phase shift element includes an antenna, a first dielectric layer, a ground plane mounted to a first surface of the first dielectric layer, a reflecting circuit, and a single antenna-reflector line connected between the antenna and the reflecting circuit through the ground plane and the first dielectric layer. The antenna-reflector line is formed of a conducting material. The reflecting circuit is mounted to a second surface of the first dielectric layer. The first surface is opposite the second surface. The reflecting circuit is configured to reflect a signal received on the single antenna-reflector line from the antenna back to the antenna on the single antenna-reflector line. The reflecting circuit is further configured to be switchable between two different impedance levels that each provide a different phase shift when the signal is reflected by the reflecting circuit. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/567965 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/46 (20130101) Original (OR) Class H01Q 19/108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230216455 | Wagner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northrop Grumman Systems Corporation (Falls Church, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric C. Wagner (Redondo Beach, California); Timothy R. LaRocca (Redondo Beach, California) |
| ABSTRACT | A radio frequency (RF) summer circuit having a characteristic impedance Z0 comprises first and second ports coupled by first and second resistances, respectively, to a junction. The circuit further comprises a series combination of a third resistance and a switch movable between open and closed positions and an amplifier having input and output terminals and operable in an off state and an on state wherein the series combination is coupled across the input and output terminals of the amplifier between the junction and a third port. The first resistance, second resistance, and the third resistance are all substantially equal to Z0/3. Further, when the switch is moved to the closed position and the amplifier is switched to the off state a passive mode of operation is implemented and when the switch is moved to the open position and the amplifier is switched to the on state an active mode of operation is implemented. The RF summer circuit develops a summed signal at the third port equal to a sum of signals at the first and second ports modified by one of first and second gain values. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/114401 |
| CURRENT CPC | Amplifiers H03F 1/56 (20130101) H03F 3/72 (20130101) H03F 3/195 (20130101) Original (OR) Class H03F 2200/451 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230210469 | Dargam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Valentina Dargam (Miami, Florida); Joshua Daniel Hutcheson (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Valentina Dargam (Miami, Florida); Joshua Daniel Hutcheson (Miami, Florida) |
| ABSTRACT | Systems and methods for quantifying the duration of S1 and/or S2 heart sounds, in order to identify markers of heart failure and/or lung failure, are provided. Cardiac cycles containing S1 and S2 sound can be identified in a phonocardiogram and normalized. In order to quantify S1 and S2 sound length, the envelope of the absolute value of the signal can be obtained for each cycle. The sound waves of two components can be separated using the identified single sound wave. These features can be correlated to measures of heart failure and/or lung failure. |
| FILED | Thursday, December 29, 2022 |
| APPL NO | 18/147969 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/725 (20130101) A61B 5/7246 (20130101) A61B 5/7257 (20130101) A61B 5/7264 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210566 | Ishihara et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ostiio LLC (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett Ishihara (Philadelphia, Pennsylvania); Matthew Nowick (Philadelphia, Pennsylvania); Justen England (Philadelphia, Pennsylvania); Kyle Woodard (Philadelphia, Pennsylvania); Henry Mayne (Philadelphia, Pennsylvania); Oivind Brockmeier (Philadelphia, Pennsylvania) |
| ABSTRACT | A distraction system can include a distraction implant comprising a magnetic element and a distraction mechanism configured to expand the distraction implant in response to rotation of the magnetic element. The distraction system can include an external device comprising a motor configured to rotate a driver magnet while in a powered state, the driver magnet configured to rotate the magnetic element, a computing device configured. The computing device can be configured to measure an electrical current drawn by the motor during rotation of the driver magnet. The computing device can be configured to maintain the motor in the powered state in response to a mean value of the electrical current being greater than or equal to a mean value threshold, and a standard deviation value of the electrical current being less than or equal to a standard deviation threshold. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/149846 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/8004 (20130101) Original (OR) Class A61B 34/10 (20160201) A61B 34/25 (20160201) A61B 90/98 (20160201) A61B 2017/00123 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230210908 | VEISEH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Omid VEISEH (Houston, Texas); Amanda NASH (Houston, Texas); Bhagyashree Kishor BACHHAV (Houston, Texas); Carlos Alberto ORIGEL MARMOLEJO (Houston, Texas); Damon BERMAN (Houston, Texas); Christian SCHREIB (Houston, Texas); Laura SEGATORI (Houston, Texas); Alen TRUBELJA (Houston, Texas); Oleg A. IGOSHIN (Houston, Texas); Andrew D. HECHT (Houston, Texas) |
| ABSTRACT | The present disclosure provides expression constructs designed to provide for expression of therapeutic proteins from engineered cells. The engineered cells may be encapsulated into implantable elements that allow for the therapeutic protein to be released into from the capsule while protecting the cell from the immune system of a patient into which the capsule is implanted. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/904106 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/36 (20130101) Original (OR) Class A61K 38/00 (20130101) Peptides C07K 14/55 (20130101) C07K 14/7155 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0686 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) C12N 2830/001 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211053 | KUMTA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | PRASHANT N. KUMTA (PITTSBURGH, Pennsylvania); SUNG JAE CHUNG (PITTSBURGH, Pennsylvania); PARTHA SAHA (PITTSBURGH, Pennsylvania); OLEG VELIKOKHATNYI (PITTSBURGH, Pennsylvania); MONI KANCHAN DATTA (PITTSBURGH, Pennsylvania); DAE HO HONG (PITTSBURGH, Pennsylvania); DA-TREN CHOU (PITTSBURGH, Pennsylvania) |
| ABSTRACT | The invention relates to biodegradable iron alloy-containing compositions for use in preparing medical devices. In addition, biodegradable crystalline and amorphous compositions of the invention exhibit properties that make them suitable for use as medical devices for implantation into a body of a patient. The compositions include elemental iron and one or more elements selected from manganese, magnesium, zirconium, zinc and calcium. The compositions can be prepared using a high energy milling technique. The resulting compositions and the devices formed therefrom are useful in various surgical procedures, such as but not limited to orthopedic, craniofacial and cardiovascular. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/113676 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/022 (20130101) Original (OR) Class A61L 31/148 (20130101) Alloys C22C 38/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211339 | Du et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (Boca Raton, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | E Du (Boca Raton, Florida); Darryl Dieujuste (Boca Raton, Florida); Jia Liu (Boca Raton, Florida); Yuhao Qiang (Boca Raton, Florida) |
| ABSTRACT | An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/118277 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2300/06 (20130101) B01L 2300/16 (20130101) B01L 2300/025 (20130101) B01L 2300/0645 (20130101) B01L 2300/0809 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 33/4915 (20130101) G01N 2015/0073 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211340 | Du et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (Boca Raton, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | E Du (Boca Raton, Florida); Darryl Dieujuste (Boca Raton, Florida); Jia Liu (Boca Raton, Florida); Yuhao Qiang (Boca Raton, Florida) |
| ABSTRACT | An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/118279 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2300/06 (20130101) B01L 2300/16 (20130101) B01L 2300/025 (20130101) B01L 2300/0645 (20130101) B01L 2300/0809 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 33/4915 (20130101) G01N 2015/0073 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211408 | Islam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona); CACTUS MATERIALS, INC. (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafiqul Islam (Gilbert, Arizona); Francois Perreault (Tempe, Arizona) |
| ABSTRACT | The instant disclosure is directed to passivated silver nanoparticle coatings and methods of making the same. A method may comprise obtaining a substrate having a surface, exposing the surface to a plurality of silver nanoparticles, applying a nucleating agent to the silver nanoparticles to form a plurality of silver cores, and passivating the silver cores by applying a sulfidation agent to the silver cores to form silver sulfide shells around the silver cores, thereby forming a coating comprising a plurality of sulfidated silver nanoparticles having a core-shell structure. The method may be used to form a coating comprising a plurality of sulfidated silver nanoparticles having a core-shell structure. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 18/000587 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/16 (20220101) B22F 1/054 (20220101) Original (OR) Class B22F 1/145 (20220101) B22F 2301/255 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 5/1618 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 24/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211558 | Sherehiy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Andriy Sherehiy (Louisville, Kentucky); Dan O. Popa (Louisville, Kentucky); Danming Wei (Prospect, Kentucky); Andrew Scott Nimon (Louisville, Kentucky); Moath Hasan Alqatamin (Louisville, Kentucky); Alireza Tofangchi (Louisville, Kentucky); Keng Hsu (Louisville, Kentucky); Kevin Walsh (Louisville, Kentucky); Cindy Harnett (Louisville, Kentucky); Thad Druffel (Louisville, Kentucky); Dilan Ratnayake (Louisville, Kentucky); Alexander Curry (Finchville, Kentucky); Sushmita Challa (Evans, Georgia); Amir Hossein Ghahremani (Toledo, Ohio); Doug Jackson (New Albany, Indiana); Ruoshi Zhang (Louisville, Kentucky); Antoine Blasiak (Paris, France); M. Hossein Saadatzi (Columbus, Ohio); Garrett McGrady (Louisville, Kentucky) |
| ABSTRACT | Systems and methods for additive manufacturing. In some examples, a system includes a frame defining an interior volume and an overhead robotic arm suspended from a gantry on a ceiling of the frame. The system includes manufacturing subsystems located within the interior volume of the frame. The system includes a control system configured for controlling the overhead robotic arm for parts movement among additive manufacturing processes using the manufacturing subsystems. The manufacturing subsystems can include one or more of: a microassembly station, an aerosol jetting print station, an intense pulsed light (IPL) photonic sintering station, a fiber weaving station, and a 3D printing station. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845526 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) B29C 64/171 (20170801) B29C 64/209 (20170801) B29C 64/236 (20170801) B29C 64/264 (20170801) B29C 64/379 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212102 | McGrath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominic V. McGrath (Tucson, Arizona); Tarek H. El Assaad (Tucson, Arizona) |
| ABSTRACT | The present invention provides a method for oxidizing pyrenes without any metal-mediated catalyst or reagent. In particular, the present invention provides a method for selectively oxidizing the K-region of pyrenes using a meta-free oxidizing agent to produce a pyrene 4,5-dione and/or a pyrene 4,5,9,10-tetraone compounds. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/009656 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 45/28 (20130101) Original (OR) Class C07C 2603/50 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212626 | Avalos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Jose L. Avalos (Princeton, New Jersey); Jared E. Toettcher (Princeton, New Jersey); Evan M. Zhao (Clarence Center, New York); Makoto A. Lalwani (San Jose, California) |
| ABSTRACT | Disclosed is a technique for constructing optogenetic amplifier and inverter circuits utilizing transcriptional activator/repressor pairs, in which expression of the transcriptional activator or repressor, respectively, is controlled by light-controlled transcription factors. This system is demonstrated utilizing the quinic acid regulon system from Neurospora crassa, or Q System, a transcriptional activator/repressor system. This is also demonstrated utilizing the galactose regulon from Saccharomyces cerevisiae, or GAL System. Such optogenetic amplifier circuits enable multi-phase microbial fermentations, in which different light schedules are applied in each phase to dynamically control different metabolic pathways for the production of proteins, fuels or chemicals. The orthogonal nature of the Q and GAL systems enable the co-expression of amplifier and inverter circuits to simultaneously amplify and invert the response of light-controlled transcriptional controls over different sets of genes in the same cell. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/087169 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 9/0006 (20130101) C12N 9/88 (20130101) C12N 9/1022 (20130101) C12N 15/81 (20130101) C12N 15/635 (20130101) C12N 2529/10 (20130101) C12N 2800/102 (20130101) C12N 2830/002 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/56 (20130101) C12P 17/06 (20130101) Original (OR) Class Enzymes C12Y 101/01027 (20130101) C12Y 202/01006 (20130101) C12Y 401/01005 (20130101) C12Y 403/01023 (20130101) C12Y 403/01024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212633 | Jewett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Jessica Carol Stark (Evanston, Illinois); Matthew P. DeLisa (Ithaca, New York); Thapakorn Jaroentomeechai (Ithaca, New York) |
| ABSTRACT | Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated carrier proteins. The glycosylated carrier proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated carrier proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated carrier proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068435 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/0208 (20130101) A61K 39/0258 (20130101) A61K 2039/6037 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212681 | Yan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao Yan (Chandler, Arizona); Rizal Hariadi (Phoenix, Arizona); Swarup Dey (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein is a transmembrane nanosensor device comprising a lipid conjugated DNA tweezer, and methods of using the same. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/799755 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212743 | Kishore Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Deepan Kishore Kumar (San Jose, California); Nai-Chang Yeh (Pasadena, California) |
| ABSTRACT | A method of growing one or more graphene sheets on one or more regions of an optical fiber using plasma-enhanced chemical vapor deposition (PECVD) includes placing the optical fiber in a growth chamber, placing one or more carbon-containing precursors in the growth chamber, forming a reduced pressure in the growth chamber, and flowing methane gas and hydrogen gas into the growth chamber. The method also includes generating a plasma in the growth chamber, forming a gaseous carbon-containing precursor from the one or more carbon-containing precursors, exposing the one or more regions of the optical fiber to the methane gas, the hydrogen gas, the gaseous carbon-containing precursor, and the plasma, and forming the one or more graphene sheets on the one or more regions of the optical fiber. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/086996 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) Original (OR) Class C23C 16/511 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/32449 (20130101) H01J 37/32743 (20130101) H01J 37/32816 (20130101) H01J 2237/3321 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213332 | MACDONALD |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Via Separations, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon Ian MACDONALD (Maynard, Massachusetts) |
| ABSTRACT | An apparatus for measuring the thickness of graphene oxide coatings deposited on a support substrate are described. The apparatus includes a light source and a photodetector which can be placed directly into a coating line to provide continuous feedback on the thickness of a fabricated graphene oxide coating, enabling fabrication of controlled thickness coatings and real-time quality monitoring. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/117722 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/198 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/84 (20130101) C01P 2004/03 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/0625 (20130101) Original (OR) Class G01B 11/0691 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213360 | Chung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jae-Hyun Chung (Seattle, Washington); Sang-Gyeun Ahn (Seattle, Washington); Tianyi Li (Seattle, Washington); Zhongjie Qian (Seattle, Washington); Vigneshwar Sakthivelpathi (Seattle, Washington) |
| ABSTRACT | A capacitive sensor including an electrically conductive material, and a single electrode applied with positive potential, wherein the distance between the single electrode and the electrically conductive material determines the spherical radius for a proximity sensing range. |
| FILED | Thursday, December 29, 2022 |
| APPL NO | 18/091219 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/24 (20130101) Original (OR) Class Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 22/02 (20130101) Electric Digital Data Processing G06F 3/011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213471 | XIAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yi XIAO (Cary, North Carolina); Yingzhu LIU (Wuhan, China PRC); Juan CANOURA (Hialeah Gardens, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Yi XIAO (Cary, North Carolina); Yingzhu LIU (Wuhan, China PRC); Juan CANOURA (Hialeah Gardens, Florida) |
| ABSTRACT | The subject invention provides methods for fabricating electrochemical aptamer-based (E-AB) sensors with enhanced sensitivity, signal-to-noise ratios, LOD, and improved stability and reproducibility. The subject invention also provides methods for aptamer immobilization on the surface of the electrode, which favors sufficient spacing between aptamers at the microscale to achieve optimal target recognition, folding, and signal transduction. The E-AB sensors of the subject invention provide superior sensing regardless of the sequence or structure of the bound aptamers or the physiochemical properties of the target. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/065118 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3276 (20130101) Original (OR) Class G01N 27/3277 (20130101) G01N 33/5308 (20130101) G01N 33/5438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213545 | Cotrufo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria Francesca Cotrufo (Fort Collins, Colorado); Michelle Haddix (Fort Collins, Colorado); Rebecca Even (Fort Collins, Colorado); Kolbin Dahley (Denver, Colorado); Travis Johnson (Fort Collins, Colorado); Andrew Kollar (Fort Collins, Colorado); Jayvin Krzych (Fort Collins, Colorado); Kyle Palmiscno (Loveland, Colorado) |
| ABSTRACT | A soil fractionation system can include a plurality of sample racks propelled by a drive system. Each sample rack can include a sample tube for holding a soil sample and a filter cup for receiving an extracted fraction of the soil sample. An extractor module of the fractionation system can include an extractor assembly and a filter assembly. A control system can control the relative positioning of the plurality of sample racks via the drive system, the relative movement between the extractor assembly and the sample tube, and the relative movement between the filter assembly and the filter cup. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/094254 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/1004 (20130101) G01N 35/1083 (20130101) Original (OR) Class G01N 2035/00485 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213647 | RAPPAPORT |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore S. RAPPAPORT (Raleigh, North Carolina) |
| ABSTRACT | An example system and method provides radiating into the 3D environment a millimeter wave (mmWave) radio frequency (RF) radiation signal that interacts with reflective surfaces, penetrable surfaces, scattering surfaces of the 3D environment, producing respective multipath components, determining information from two or more of the multipath components, including two among, or, optionally, all of angle of arrival (AoA), angle of departure (AoD), time of arrival, relative time of arrival (RTA), and phase and, based on the information and the received multipath components, performs computing the user device’s relative or absolute mobile device location in relation to the surrounding 3D environment, and providing images or video of the surrounding 3D environment to a display or a storage of the user’s mobile device, for displaying or storing. |
| FILED | Friday, March 10, 2023 |
| APPL NO | 18/181987 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/46 (20130101) G01S 13/89 (20130101) Original (OR) Class G01S 13/888 (20130101) G01S 2013/464 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230214242 | Sivakumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raghupathy Sivakumar (Atlanta, Georgia); Uma Parthavi Moravapalle (Atlanta, Georgia) |
| ABSTRACT | A method for task mobilization may include a server receiving user inputs from a desktop application. A user input may correspond to a respective function performed by a user on the desktop application. A processor may identify the respective functions of the user inputs. Further, the method may include translating the respective functions into respective mobile view functions. Based on the respective mobile view functions, the processor may generate a mobile application and provide the mobile application to a mobile user device. |
| FILED | Friday, March 10, 2023 |
| APPL NO | 18/181672 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/76 (20130101) Original (OR) Class G06F 9/451 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230214661 | Perdikaris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paris Georgios Perdikaris (Philadelphia, Pennsylvania); George J. Pappas (Philadelphia, Pennsylvania); Jacob Hugh Seidman (Philadelphia, Pennsylvania); Georgios Kissas (Philadelphia, Pennsylvania) |
| ABSTRACT | Supervised operator learning is an emerging machine learning paradigm with applications to modeling the evolution maps of spatio-temporal dynamical systems and approximating general black-box relationships between functional data. We propose a novel operator learning method, LOCA (Learning Operators with Coupled Attention), motivated from the attention mechanism. The input functions are mapped to a finite set of features which are then averaged with attention weights that depend on the output query locations. By coupling these attention weights together with an integral transform, LOCA is able to explicitly learn correlations in the target output functions, enabling us to approximate nonlinear operators even when the number of output function measurements is very small. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/092888 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/09 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230216040 | LAINE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RICHARD M. LAINE (Ann Arbor, Michigan); ELENI TEMECHE (Ann Arbor, Michigan); TAYLOR BRANDT (Ann Arbor, Michigan); PHILYONG KIM (Ann Arbor, Michigan) |
| ABSTRACT | An electrode for an electrochemical device is disclosed. The electrode comprises a lithium host material; and a porous coating on the lithium host material. The porous coating can comprise a solid-state ion conducting electrolyte material selected from: (i) lithium aluminum oxides, (ii) lithium containing phosphates, (iii) LixPON wherein x is 1, 1.5, 3, or 6, (iv) LixSiPON wherein x is 1, 1.5, 3, or 6, (v) LixSiON wherein x is 2, 4, or 6, (vi) lithium lanthanum zirconium oxides, and (vii) mixtures of two or more of (i), (ii), (iii), (iv), (v), and (vi). The porous coating comprising the solid-state ion conducting electrolyte material may be formed from one or more precursors that form the porous coating comprising the solid-state ion conducting electrolyte material upon cycling of the electrochemical device. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/091478 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) H01M 4/382 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230211393 | HAZARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Western Research Institute (Laramie, Wyoming) |
| ASSIGNEE(S) | Western Research Institute (Laramie, Wyoming) |
| INVENTOR(S) | LeAnne V. HAZARD (Laramie, Wyoming); Justin L. MARTIN (Laramie, Wyoming); Frank D. GUFFEY (Laramie, Wyoming) |
| ABSTRACT | In one embodiment, a method for processing polymeric waste materials into one or more products included: pyrolyzing a solid polymeric waste material, wherein the pyrolyzing includes: heating the solid polymeric waste material in the absence of oxygen to a temperature of 725° F. to 850° F. for a duration of 15 to 90 minutes; and thermochemically converting, in response to the heating step, at least some of the solid polymeric waste material into a first liquid product; separating the first liquid product from residual solids; separating a vapor stream from the vessel; and condensing at least a portion of the vapor stream into a second liquid product. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/150435 |
| CURRENT CPC | Disposal of Solid Waste B09B 3/40 (20220101) Original (OR) Class B09B 3/80 (20220101) B09B 2101/75 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211415 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carpenter Technology Corporation (Philadelphia, Pennsylvania); UT-BATTELLE, LLC (OaK Ridge, Tennessee); West Virginia University Board of Governors on behalf of West Virginia University (Morgantown, West Virginia); General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingbo LIU (Morgantown, West Virginia); Zhili FENG (Knoxville, Tennessee); Yanli WANG (Knoxville, Tennessee); David NOVOTNAK (Mcdonald, Pennsylvania); Haiyang QIAN (Avon, Connecticut) |
| ABSTRACT | A method for producing an additively manufactured, graded composite transition joint (AM-GCTJ) includes preparing a grating or lattice pattern from a first alloy A; the grating or lattice pattern includes pores in the grating or lattice patterns. The grating pattern is built from a first end to a second end being denser on the first end than on second end, and gradually reduces density by increasing the pore size and/or reducing density of the grating or lattice pattern; adding a second alloy B powder to the second end of grating or lattice pattern. The second alloy B powder is filled towards the first end. A composite is formed of first alloy A and second alloy B powder in the AM-GCTJ. The composite is subjected to hot isotropic pressing (HIP) to densify the composite. The second alloy B is graduated from the first end to the second end O of AM-GCTJ. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/000622 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 7/002 (20130101) B22F 7/064 (20130101) Original (OR) Class B22F 10/28 (20210101) B22F 10/64 (20210101) B22F 2301/35 (20130101) B22F 2998/10 (20130101) B22F 2999/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211561 | Agarwal et al. |
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| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Vivek Agarwal (Idaho Falls, Idaho); Sasa Kovacevic (Pullman, Washington); John Buttles (Idaho Falls, Idaho) |
| ABSTRACT | A system for managing additive manufacturing (AM) may comprise a datastore configured to store entries pertaining to a design for a three-dimensional (3D) object. The entries may be configured to include a respective set of parameters for an AM process. The parameters may be configured to cause an AM system to produce 3D objects having anisotropic mechanical properties that satisfy specified anisotropic mechanical requirements. The system may further comprise a design manager configured to determine a set of parameters that optimally satisfy the specified requirements, e.g., satisfy the requirements at a minimal cost. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/570306 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/02 (20141201) Electric Digital Data Processing G06F 30/12 (20200101) G06F 2111/20 (20200101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212041 | Hall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Faraday Technology, Inc. (Englewood, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy D. Hall (Englewood, Ohio); Maria E. Inman (Yellow Springs, Ohio); Stephen T. Synder (Englewood, Ohio); Santosh H. Vijapur (Beavercreek, Ohio); E. Jennings Taylor (Bonita Springs, Florida); Thi Xuan Huong Le (Dayton, Ohio) |
| ABSTRACT | A dewatering apparatus for cellulosic materials includes a chamber for an aqueous solution of a cellulosic material, an inner electrode in the chamber, an outer electrode in the chamber about the inner electrode, and a power supply connected to the inner electrode and the outer electrode applying a voltage potential across the electrodes to remove water associated with the aqueous solution and to dewater the cellulosic materials. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068895 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/469 (20130101) C02F 1/46109 (20130101) Original (OR) Class C02F 2001/46157 (20130101) C02F 2201/46 (20130101) C02F 2201/46115 (20130101) C02F 2201/46175 (20130101) Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor D21C 9/007 (20130101) D21C 9/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212626 | Avalos et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Jose L. Avalos (Princeton, New Jersey); Jared E. Toettcher (Princeton, New Jersey); Evan M. Zhao (Clarence Center, New York); Makoto A. Lalwani (San Jose, California) |
| ABSTRACT | Disclosed is a technique for constructing optogenetic amplifier and inverter circuits utilizing transcriptional activator/repressor pairs, in which expression of the transcriptional activator or repressor, respectively, is controlled by light-controlled transcription factors. This system is demonstrated utilizing the quinic acid regulon system from Neurospora crassa, or Q System, a transcriptional activator/repressor system. This is also demonstrated utilizing the galactose regulon from Saccharomyces cerevisiae, or GAL System. Such optogenetic amplifier circuits enable multi-phase microbial fermentations, in which different light schedules are applied in each phase to dynamically control different metabolic pathways for the production of proteins, fuels or chemicals. The orthogonal nature of the Q and GAL systems enable the co-expression of amplifier and inverter circuits to simultaneously amplify and invert the response of light-controlled transcriptional controls over different sets of genes in the same cell. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/087169 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 9/0006 (20130101) C12N 9/88 (20130101) C12N 9/1022 (20130101) C12N 15/81 (20130101) C12N 15/635 (20130101) C12N 2529/10 (20130101) C12N 2800/102 (20130101) C12N 2830/002 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/56 (20130101) C12P 17/06 (20130101) Original (OR) Class Enzymes C12Y 101/01027 (20130101) C12Y 202/01006 (20130101) C12Y 401/01005 (20130101) C12Y 403/01023 (20130101) C12Y 403/01024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212905 | Petit |
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| FUNDED BY |
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| APPLICANT(S) | V-GLASS, INC. (Pewaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Petit (Pewaukee, Wisconsin) |
| ABSTRACT | An evacuated glazing assembly has first and second spaced-apart, non-metal substrates connected to each other by a seal element to form an evacuable interior space therebetween. The seal element is formed by bonding a metallic bridge element to at least one of the substrates by cold welding to form a first stage seal and forming a second stage seal at least partially in contact with the first stage seal. The seal element is configured to hermetically isolate the interior space from the surrounding environment, and both the first stage seal and the second stage seal contribute to the hermeticity of the seal element. |
| FILED | Tuesday, September 08, 2020 |
| APPL NO | 18/001166 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 27/08 (20130101) C03C 27/10 (20130101) Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 3/6612 (20130101) Original (OR) Class E06B 3/6617 (20130101) E06B 3/66304 (20130101) E06B 3/66357 (20130101) E06B 3/67334 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213024 | Simmonds et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Jacob Simmonds (Princeton, New Jersey); Yevgeny Raitses (Princeton, New Jersey) |
| ABSTRACT | Disclosed is a miniaturized plasma propulsion device with minimized surface area of the thruster walls exposed to the plasma and, as a result, reduced plasma-surface interactions including a set of segmented electrodes to facilitate the following improvements compared to relevant existing technologies: 1) control of the plasma flow including focusing of the plasma plume 2) increase of the thrust 2) reduction of inefficiencies associated with the electron cross field current, and 3) mitigation of low frequency oscillations. The electrodes affect all these actions when a DC or modulated voltage is applied to one or all of them with the same or different amplitudes, with the same or different frequencies or phases which are all optimized to realize the best performance through changes in the acceleration and/or ionization regions. In addition, the applied voltage to the main electrodes may also be modulated. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896651 |
| CURRENT CPC | Producing a Reactive Propulsive Thrust, Not Otherwise Provided for F03H 1/0068 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213440 | Terracciano et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony C. Terracciano (Orlando, Florida); Subith S. Vasu (Orlando, Florida); Francisco J. Gonzalez (Orlando, Florida) |
| ABSTRACT | A high-altitude atmospheric sensor may include a frame configured to attach to a body of an aircraft, where the frame defines an open measurement cavity for air to travel through during flight of the aircraft. The sensor may further include one or more light sources providing input light such as mid-infrared quantum cascade lasers, a beamsplitter to separate the input light into measurement light propagating along a measurement path and reference light propagating along a reference path, one or more measurement cells providing optical paths for the measurement light in the open measurement cavity of the frame, one or more detectors to capture the measurement light from the one or more measurement cells and the reference light, and a controller to generate one or more spectroscopy measurements of air passing through the open measurement cavity during the flight of the aircraft. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980379 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/255 (20130101) G01N 21/3504 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230214661 | Perdikaris et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paris Georgios Perdikaris (Philadelphia, Pennsylvania); George J. Pappas (Philadelphia, Pennsylvania); Jacob Hugh Seidman (Philadelphia, Pennsylvania); Georgios Kissas (Philadelphia, Pennsylvania) |
| ABSTRACT | Supervised operator learning is an emerging machine learning paradigm with applications to modeling the evolution maps of spatio-temporal dynamical systems and approximating general black-box relationships between functional data. We propose a novel operator learning method, LOCA (Learning Operators with Coupled Attention), motivated from the attention mechanism. The input functions are mapped to a finite set of features which are then averaged with attention weights that depend on the output query locations. By coupling these attention weights together with an integral transform, LOCA is able to explicitly learn correlations in the target output functions, enabling us to approximate nonlinear operators even when the number of output function measurements is very small. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/092888 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/09 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230214978 | Brannigan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Eric Michael Brannigan (Lenexa, Kansas); Benjamin Ross Brown (Lee's Summit, Missouri) |
| ABSTRACT | A method of detecting a deformation in a lattice structure comprises capturing first image data of the lattice structure via a first image capturing device with a first telecentric lens and a second image capturing device with a second telecentric lens. The first telecentric lens is directed toward the lattice structure, and the second telecentric lens is spaced apart from the first telecentric lens and also directed toward the lattice structure. The method includes compressing the lattice structure; capturing second image data of the lattice structure via the first and second image capturing devices; and detecting the deformation based at least in part on the first and second image data. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/568861 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 5/0091 (20130101) Optical Elements, Systems, or Apparatus G02B 13/22 (20130101) Image Data Processing or Generation, in General G06T 7/0002 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/247 (20130101) H04N 5/2256 (20130101) H04N 5/2354 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230215678 | KAPADIA et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rehan KAPADIA (Glendale, California); Hyun Uk CHAE (Los Angeles, California); Ragib AHSAN (Los Angeles, California); Subrata DAS (Los Angeles, California) |
| ABSTRACT | A HELAC device includes a semiconductor layer that absorbs incident photons, a graphene monolayer disposed over the semiconductor layer, and an insulator layer interposed between the semiconductor layer and graphene monolayer. The graphene monolayer is configured as a gate for the HELAC device while the insulator layer is configured to allow a voltage drop between the semiconductor layer and graphene. Advantageously, the HELAC device is configured to receive photons on an emitter surface and to emit hot electrons therefrom. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940113 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 1/34 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230216039 | MANTHIRAM et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arumugam MANTHIRAM (Austin, Texas); Sanjay NANDA (Austin, Texas); Amruth BHARGAV, III (Austin, Texas) |
| ABSTRACT | Described herein are electrodes, electrochemical cells, methods of making electrodes and methods of making electro-chemical cells. The electrodes described herein have an interface layer or material that can stabilize reversible alkali metal deposition. The interface material may correspond to or be a solid-electrolyte interphase that can allow alkali metal ions to transmit through and be deposited below the interface material. The interface material can prevent dendrite formation and/or decomposition of the electrolyte, enabling use of lithium metal safely in a secondary (i.e., rechargeable) electrochemical cell. The interface material may comprise a combination of one or more metals, one or more chalcogens, and one or more other elements or organic functional groups. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/912680 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/381 (20130101) Original (OR) Class H01M 4/0445 (20130101) H01M 4/621 (20130101) H01M 50/414 (20210101) H01M 50/449 (20210101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230216082 | Ullman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sepion Technologies, Inc. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Ullman (Emeryville, California); Jon-Michael Alessandro (Emeryville, California); Peter D. Frischmann (Emeryville, California) |
| ABSTRACT | The present invention provides compositions including polyelectrolyte complexes. The composition includes: 1) an inorganic salt comprising a metal ion having a charge of at least +1 and an anion having a charge of at least −1; and 2) a complex comprising a first species and a second species, wherein the first species is a positively charged polymerizable monomer or a first charged polymer comprising one or more positively charged monomer repeat units; the second species is a negatively charged polymerizable monomer or a second charged polymer comprising one or more negatively charged monomer repeat units; and the complex has a net charge of near zero. These compositions are useful for ion selective applications in electrochemical devices. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/999706 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/056 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230216091 | Babinec et al. |
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| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Susan J. Babinec (Midland, Michigan); Timothy Fister (Oak Park, Illinois); Pietro Papa Lopes (Woodridge, Illinois); Vojislav Stamenkovic (Naperville, Illinois) |
| ABSTRACT | An electrochemical cell assembly includes an electrochemical cell including housing and a negative active material disposed within a first electrode chamber of the housing. The negative active material includes lead. The electrochemical cell further includes a positive active material disposed within a second electrode chamber of the housing and a separator disposed in the housing between the first electrode chamber and the second electrode chamber. The positive active material includes lead and/or lead dioxide. The electrochemical cell assembly further includes a pumping assembly configured to pump a plurality of electrolytes through either the first electrode chamber or the second electrode chamber during operation of the electrochemical cell based on a process of a cell cycle of the electrochemical cell. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/566340 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/08 (20130101) H01M 10/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230216294 — HYBRIDIZED TRANSMISSION SWITCHING FOR CONTINGENCY MANAGEMENT IN ELECTRIC POWER SYSTEMS
| US 20230216294 | SURYANARAYANAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado); BATTELLE ENERGY ALLIANCE, LLC (ldaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siddharth SURYANARAYANAN (Brookings, South Dakota); Tanveer HUSSAIN (Brookings, South Dakota); S M Shafiul ALAM (Idaho Falls, Idaho) |
| ABSTRACT | Disclosed herein are systems and methods to perform hybridized transmission switching of an electric power system to avoid exceeding line ratings and minimize load shedding. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 18/009197 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/0012 (20200101) H02J 3/14 (20130101) H02J 3/00125 (20200101) Original (OR) Class H02J 3/381 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230216469 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tammy Chang (San Ramon, California); Lars F. Voss (Livermore, California); Joseph D. Schneider (Livermore, California) |
| ABSTRACT | Disclosed are apparatuses and methods of tuning a radio frequency circuit using stub tuners and photoconductive switches. In one aspect an electromagnetic stub tuner apparatus is disclosed. the apparatus includes a transmission line, and a photoconductive switch positioned along the length of the transmission line. The photoconductive switch is configured to turn on or turn off, wherein an impedance of the transmission line is changed when the photoconductive switch is turned on compared to when the photoconductive switch is turned off. In another aspect, a method of tuning a radio frequency circuit is disclosed. In yet another aspect, a method of producing a radio frequency tuning circuit is disclosed. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/564110 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/127 (20130101) H01P 1/2039 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230211460 | Kutscha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Arlington, Virginia) |
| ASSIGNEE(S) | The Boeing Company (Arlington, Virginia) |
| INVENTOR(S) | Eileen O. Kutscha (Seattle, Washington); Kay Y. Blohowiak (Issaquah, Washington) |
| ABSTRACT | There is provided a quantitative method for determining a level of a sanding surface preparation of a carbon fiber composite surface, prior to the carbon fiber composite surface undergoing a post-processing operation. The quantitative method includes fabricating a ladder panel of levels of sanding correlating to an amount of sanding of sanding surface preparation standards for a reference carbon fiber composite surface of reference carbon fiber composite structure(s); using surface analysis tools to create target values for quantifying the levels of sanding; measuring, with the surface analysis tools, sanding surface preparation location(s) on the carbon fiber composite surface of a test carbon fiber composite structure, to obtain test result measurement(s); comparing the test result measurement(s) to the levels, to obtain test result level(s); determining if the test result level(s) meet the target values; and determining whether the carbon fiber composite surface is acceptable to proceed with the post-processing operation. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/173016 |
| CURRENT CPC | Machines, Devices, or Processes for Grinding or Polishing; Dressing or Conditioning of Abrading Surfaces; Feeding of Grinding, Polishing, or Lapping Agents B24B 49/12 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3563 (20130101) G01N 2021/8411 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211511 | DADKHAH TEHRANI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ONROBOT A/S (Odense, Denmark) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad DADKHAH TEHRANI (Los Angeles, California); Nicholas WETTELS (Los Angeles, California) |
| ABSTRACT | Provided are systems and methods for the post-treatment of dry adhesive microstructures. The microstructures may be post-treated to comprise mushroom-like flaps at their tips to interface with the contact surface. In some aspects, a change in material composition of the microstructures in a dry adhesive may affect mechanical properties to enhance or diminish overall adhesive performance. For example, conductive additives can be added to the material to improve adhesive performance. In other aspects, microstructures comprising conductive material may allow for pre-load engagement sensing systems to be integrated into the microstructures. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/982350 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 15/0085 (20130101) Original (OR) Class Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00 (20130101) B81C 1/00206 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/00 (20130101) C09J 9/02 (20130101) C09J 11/04 (20130101) C09J 201/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211528 | Jenett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); United States Government as Represented by The Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); United States Government as Represented by The Administrator of NASA (Washington, District of Columbia) |
| INVENTOR(S) | Benjamin Jenett (Cambridge, Massachusetts); Neil Gershenfeld (Cambridge, Massachusetts); Kenneth Cheung (Emerald Hills, California); Christine Gregg (Emerald Hills, California) |
| ABSTRACT | A method for the design, manufacture, and assembly of modular lattice structures composed of cuboctahedron unit cells. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 18/055136 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 45/0005 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2309/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230215590 | Thomsen, III |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald L. Thomsen, III (Yorktown, Virginia) |
| ABSTRACT | Described herein are articles composed of coatings with improved gamma radiation shielding and physical properties. In one aspect, the article is composed of a coating, where the coating includes a first layer composed of a first Z grade material, a second layer composed of a second Z grade material, and a third layer composed of a third Z grade material, wherein the atomic number of the first Z grade material and the third Z grade material is less than the atomic number of the second Z grade material. In one aspect, the substrate of the article is a textile. Methods for making the articles described herein are also provided. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/569035 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/08 (20130101) C23C 4/134 (20160101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 1/125 (20130101) Original (OR) Class G21F 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230210073 | Di et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Rong Di (East Brunswick, New Jersey); Michael A. Lawton (Highland Park, New Jersey); James E. Simon (Princeton, New Jersey) |
| ABSTRACT | The disclosure provides methods of making gene-edited plants that are resistant to downy mildew, such as plants with reduced expression of homoserine kinase (HSK), 2-oxoglutarate-Fe(II) oxygenase (2OGO), or both. The disclosure further provides methods of making gene-edited modified plants that are cold tolerant, such as plants with reduced expression of MYB14. In some examples, CRISPR/Cas methods are used, wherein the plants include a mutated HSK, 2OGO, and/or MYB14 gene resulting in reduced expression and/or gene activity. Plants generated using the methods are provided. Such plants can include other desirable traits. HSK, 2OGO, and/or MYB14 nucleic acid and protein molecules are provided, as are gRNAs specific for HSK, 2OGO, or MYB14 and vectors containing such. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/914647 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/1255 (20210101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/8282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212365 | GLENN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by The Secretary of Agriculture (Washington, District of Columbia); World Centric (Rohnert Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | GREGORY M. GLENN (GRAND JUNCTION, Colorado); RANDAL SHOGREN (COLUMBIA FALLS, Montana); XING JIN (ALBANY, California) |
| ABSTRACT | The invention provides moisture-resistant foam compositions comprising at least one fiber component; at least one foaming agent; at least one wax binder; and optionally at least one dispersant, where the at least one fiber component, the at least one foaming agent, the at least one wax binder, and when present the at least one dispersant are uniformly dispersed throughout a matrix, wherein the matrix is a foam. |
| FILED | Thursday, December 29, 2022 |
| APPL NO | 18/090713 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/009 (20130101) C08J 9/28 (20130101) C08J 9/0085 (20130101) C08J 9/0095 (20130101) Original (OR) Class C08J 2205/10 (20130101) C08J 2329/04 (20130101) C08J 2401/02 (20130101) C08J 2491/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212366 | Glenn |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory M. Glenn (Grand Junction, Colorado) |
| ABSTRACT | Provided herein is a molded cellulose foam having a smooth, dense surface fiber layer and a low density, open-cell structure interior, a process for compression-molding fiber foam into such molded cellulose foam, articles prepared with such foam, and articles prepared by such process. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876040 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/30 (20130101) C08J 9/34 (20130101) Original (OR) Class C08J 9/0061 (20130101) C08J 9/0085 (20130101) C08J 9/365 (20130101) C08J 2205/05 (20130101) C08J 2301/02 (20130101) C08J 2403/02 (20130101) C08J 2491/06 (20130101) C08J 2493/02 (20130101) Compositions of Macromolecular Compounds C08L 1/02 (20130101) C08L 2203/14 (20130101) C08L 2205/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230210399 | May |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey May (Washington, District of Columbia) |
| ABSTRACT | Methods, systems, and apparatus for signal artifact detection and reduction are provided. The signal artifact may comprise an interference between an electroencephalography (EEG) signal and a magnetic resonance imaging (MRI) signal arising out of simultaneous EEG and MRI treatment. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/009608 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class A61B 5/372 (20210101) A61B 5/7207 (20130101) A61B 2576/026 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/24 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10088 (20130101) G06T 2207/30016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212276 | Clauss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias Clauss (Indianapolis, Indiana); Irina Petrache (Indianapolis, Indiana) |
| ABSTRACT | The present invention provides methods for diagnosing a patient with emphysema, COPD of lung injury caused by tobacco use by detecting the levels of EMAP II in a sample. Disclosed herein are the hypervariable regions for a rat monoclonal antibody that binds to a form of EMAP II. This disclosure also includes a polypeptide sequence included in EMAP II that is the target for the binding of the antibody to its target protein. This epitope serves as the basis for a humanized antibody that can be used to treat patients that suffer from pathologies that exhibit elevated levels of EMAP II expression. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/097078 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 16/2866 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212699 | MCCLAIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina); THE U.S. GOVERNMENT AS REPRESENTED BY THE DEPT. OF VETERANS AFFAIRS (NW Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Micah MCCLAIN (Durham, North Carolina); Chris WOODS (Durham, North Carolina); Geoffrey GINSBURG (Durham, North Carolina); Ephraim TSALIK (Cary, North Carolina); Ricardo Henao GIRALDO (Durham, North Carolina); Thomas BURKE (Durham, North Carolina); Florica CONSTANTINE (Albany, California); Elizabeth PETZOLD (Durham, North Carolina) |
| ABSTRACT | Provided are methods of making a SARS-CoV-2 (COVID-19) infection classifier for a platform, and optionally a non-COVID-19 viral infection classifier, a bacterial infection classifier, a non-infectious illness classifier, and/or a healthy subjects classifier for the platform. Methods and systems for determining the presence of SARS-CoV-2 (COVID-19) infection in a subject or for determining the viral stage of infection of a SARS-CoV-2 (COVID-19) illness in a subject suffering therefrom are also provided. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/000858 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/26 (20130101) G01N 2800/60 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230211416 | Eonta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MolyWorks Materials Corporation (Cloverdale, California) |
| ASSIGNEE(S) | MolyWorks Materiais Corporation (Cloverdale, California) |
| INVENTOR(S) | Christopher Paul Eonta (Los Gatos, California); ANDREW VanOs LaTOUR (Hayward, California); MATTHEW CHARLES (CLOVERDALE, California); TOM REED (HOPLAND, California); KAI PRAGER (HUNTINGTON BEACH, California) |
| ABSTRACT | An expeditionary additive manufacturing (ExAM) system [10] for manufacturing metal parts [20] includes a mobile foundry system [12] configured to produce an alloy powder [14] from a feedstock [16], and an additive manufacturing system [18] configured to fabricate a part using the alloy powder [14]. The additive manufacturing system [18] includes a computer system [50] having parts data and machine learning programs in signal communication with a cloud service. The parts data [56] can include material specifications, drawings, process specifications, assembly instructions, and product verification requirements for the part [20]. An expeditionary additive manufacturing (ExAM) method for making metal parts [20] includes the steps of transporting the mobile foundry system [12] and the additive manufacturing system [18] to a desired location; making the alloy powder [14] at the location using the mobile foundry system; and building a part [20] at the location using the additive manufacturing system [18]. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/113863 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/34 (20210101) B22F 12/82 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230211511 | DADKHAH TEHRANI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ONROBOT A/S (Odense, Denmark) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad DADKHAH TEHRANI (Los Angeles, California); Nicholas WETTELS (Los Angeles, California) |
| ABSTRACT | Provided are systems and methods for the post-treatment of dry adhesive microstructures. The microstructures may be post-treated to comprise mushroom-like flaps at their tips to interface with the contact surface. In some aspects, a change in material composition of the microstructures in a dry adhesive may affect mechanical properties to enhance or diminish overall adhesive performance. For example, conductive additives can be added to the material to improve adhesive performance. In other aspects, microstructures comprising conductive material may allow for pre-load engagement sensing systems to be integrated into the microstructures. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/982350 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 15/0085 (20130101) Original (OR) Class Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00 (20130101) B81C 1/00206 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/00 (20130101) C09J 9/02 (20130101) C09J 11/04 (20130101) C09J 201/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212905 | Petit |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | V-GLASS, INC. (Pewaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Petit (Pewaukee, Wisconsin) |
| ABSTRACT | An evacuated glazing assembly has first and second spaced-apart, non-metal substrates connected to each other by a seal element to form an evacuable interior space therebetween. The seal element is formed by bonding a metallic bridge element to at least one of the substrates by cold welding to form a first stage seal and forming a second stage seal at least partially in contact with the first stage seal. The seal element is configured to hermetically isolate the interior space from the surrounding environment, and both the first stage seal and the second stage seal contribute to the hermeticity of the seal element. |
| FILED | Tuesday, September 08, 2020 |
| APPL NO | 18/001166 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 27/08 (20130101) C03C 27/10 (20130101) Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 3/6612 (20130101) Original (OR) Class E06B 3/6617 (20130101) E06B 3/66304 (20130101) E06B 3/66357 (20130101) E06B 3/67334 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230211381 | COUPAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES POSTAL SERVICE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George COUPAR (Leesburg, Virginia); Jeffrey A. FOX (Alexandria, Virginia); James WHIPPLE (Greenbelt, Maryland); Gabriel DIFURIO (Stevenson, Virginia) |
| ABSTRACT | A system and method for enhanced monitoring and sorting of delivery items, such as packages, which are moved and sorted via a delivery service conveyor device. Conventional systems may employ photocells, which detect interrupted light beams, to identify packages or delivery items along a conveyor path. The present system and method enhances photocell function by adding image detection and analysis to the mail path; and further by modifying the photocell signals to the sorter/conveyor control. The present sensing system is located in the same area on the transport as the photocell, and uses a camera to capture an image of the mail path in the photocell area. The system and method then analyze a package image to formulate a more accurate item detection signal, based on photocell data and image data, for input to the sorter/conveyor control system. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/182680 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/14 (20130101) Original (OR) Class Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 43/08 (20130101) B65G 2201/0285 (20130101) B65G 2203/041 (20130101) B65G 2203/044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230214760 | Aryeetey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nii-Kwashie Aryeetey (Washington, District of Columbia); Robert E. Dixon, JR. (Washington, District of Columbia); Naomi Miller (Washington, District of Columbia) |
| ABSTRACT | Systems and methods for generating and implementing a household customer database are disclosed. In one aspect, a method for processing items comprises receiving a first item to be delivered and identifying data corresponding to one or more of a source information and destination information of the first item. The method further comprises identifying secondary information of the first item, storing the source, destination, and secondary information in a database, creating associations between the source, destination, and secondary information, receiving a request to analyze information stored and associated in the database, determining whether the database comprises information necessary to perform the requested analysis, identifying if additional information is needed to perform the requested analysis, updating the secondary information associations to include the additional information if needed to perform the requested analysis, and analyzing the information stored and associated in the database based on the received analysis request or query. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/183109 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/602 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0838 (20130101) G06Q 10/08355 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230214772 | Dearing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen M. Dearing (Herndon, Virginia); Kuldip K. Goyal (Alexandria, Virginia); Carla F. Sherry (Annandale, Virginia); Amy B. Cradic (Reston, Virginia); C. Scot Atkins (Chantilly, Virginia); Himesh A. Patel (Centerville, Virginia) |
| ABSTRACT | Systems and methods of processing items. Items in a distribution network or process may be scanned at every handling point in the distribution network, and each scan is recorded in a central repository. The scan information can be used to generate real-time access to data, analytical tools, predictive tools, and tracking reports. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/175280 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/18 (20130101) B07C 2301/0025 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/1417 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) G06Q 10/063 (20130101) G06Q 10/083 (20130101) G06Q 10/087 (20130101) Original (OR) Class G06Q 10/0833 (20130101) G06Q 30/0201 (20130101) G06Q 30/0241 (20130101) G06Q 50/28 (20130101) G06Q 50/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230211626 | Zlotnick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Joel Zlotnick (Arlington, Virginia); Jordan Brough (Leesburg, Virginia); Troy Eberhardt (Centreville, Virginia); Tyra McConnell (Knoxville, Maryland); Elizabeth Gil (Bristow, Virginia); Traci Moran (Rockville, Maryland) |
| ABSTRACT | A substrate is printed with front side and back side markings in a first color ink. The front side when viewed with reflected light includes a first marking printed in a first saturation and a first symbol printed in the first saturation. The back side when viewed with reflected light includes: a second marking printed in a second saturation; a second symbol printed in the second saturation; a third marking printed in the first saturation; and a third symbol printed in the first saturation. The first marking, the second marking, and the third marking are printed to provide an interlocking pattern of low saturation color and high saturation color when viewed with transmitted light. The second symbol is visible, and the first symbol and the second symbol are not distinguishably visible, when viewed with transmitted light. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 17/963746 |
| CURRENT CPC | Printing Machines or Presses B41F 1/16 (20130101) B41F 31/008 (20130101) Printing, Duplicating, Marking, or Copying Processes; Colour Printing, B41M 1/14 (20130101) B41M 3/14 (20130101) Original (OR) Class B41M 2205/34 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/378 (20141001) B42D 25/405 (20141001) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20230213321 | Vabnick |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Federal Bureau of Investigation (Washington, District of Columbia) |
| ASSIGNEE(S) | Federal Bureau of Investigation (Washington, District of Columbia) |
| INVENTOR(S) | Ian B. Vabnick (Fredericksburg, Virginia) |
| ABSTRACT | Disclosed is a method for rendering safe an Improvised Explosive Device (IED) via a powered mechanical press. The method includes identifying and classifying the IED and placing the IED into the press and determining a position of the IED within the press based on the classification of the IED. The method further includes activating the press until a fracturing device of the press reaches a fracture position with respect to the IED and holding the position of the press for a predetermined period of time when the fracturing device reaches the fracture position. Further, the method includes removing, after the IED has fractured, the fractured IED and explosive filler of the fractured IED. |
| FILED | Wednesday, January 04, 2023 |
| APPL NO | 18/093277 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 33/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230212273 | Jones et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tarran Jones (Radlett Hertfordshire, United Kingdom); Alison Levy (Harpenden Hertfordshire, United Kingdom); Siobhan O'Brien (Throley, United Kingdom) |
| ABSTRACT | A chimeric mouse-human antibody for treatment of amyloid deposition diseases, pharmaceutical compositions comprising the antibody, methods and materials for producing the antibody, and methods for treating an amyloid deposition disease using the antibody and the pharmaceutical composition. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066469 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230212949 | Martin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas J. Martin (East Hampton, Connecticut); Gajawalli V. Srinivasan (South Windsor, Connecticut); Paul F. Croteau (Columbia, Connecticut); Matthew B. Kennedy (Vernon, Connecticut) |
| ABSTRACT | A gas turbine engine article includes a silicon-containing ceramic wall that has an external combustion gaspath side and an internal side that borders a cooling air cavity. The external combustion gaspath side has an associated combustion gas flow direction there along. An array of cooling holes extends through the silicon-containing ceramic wall and connects the internal side with the external combustion gaspath side. The cooling holes are oriented to discharge cooling air to the external gaspath side in a direction counter to the combustion gas flow direction. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/970662 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/186 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/202 (20130101) F05D 2300/222 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230213003 | Gunasekera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony Michael Gunasekera (New Richmond, Ohio); Donald M. Corsmeier (West Chester, Ohio); Bernard J. Renggli (Cincinnati, Ohio); Steven Kirgiss (Fairfield, Ohio) |
| ABSTRACT | In some embodiments, apparatuses are provided herein useful to sealing a gap, such as a gap between a gas turbine engine nozzle flap and sidewall. An apparatus for sealing such a gap may be a plunger seal that includes a plunger, a retaining element, a guide pin, and a biasing element. The plunger includes a sealing edge and an actuating edge having at least one recess and an opening formed therein. The biasing element and a portion of the guide pin are nested in the recess. The retaining element anchor the plunger to the retaining element. The retaining element also anchors the plunger seal to the housing When installed in a gap, the housing engages the flap and the plunger engages the sidewall. The biasing element is under compression and urges the guide pin into the actuating edge to urge the plunger toward the sidewall and seal the gap. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567385 |
| CURRENT CPC | Jet-propulsion Plants F02K 1/12 (20130101) F02K 1/805 (20130101) Original (OR) Class Pistons; Cylinders; Sealings F16J 15/3436 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230216267 | Puckett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Matthew Wade Puckett (Phoenix, Arizona); Chad Fertig (Bloomington, Minnesota); Matthew Robbins (Minneapolis, Minnesota) |
| ABSTRACT | Among other embodiments, a method for generated entangled photons is disclosed. The method comprises generating photons in a fundamental mode and converting the photons from the fundamental mode to a higher-order mode. The method further comprises generating, by a Bragg resonator configured to receive the photons, entangled photons in the fundamental mode from the converted photons in the higher-order mode. The method further comprises outputting the generated entangled photons from the Bragg resonator. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567791 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0675 (20130101) H01S 3/1024 (20130101) Original (OR) Class H01S 3/06741 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 06, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
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THE PANEL
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FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230706.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page