FedInvent™ Patent Applications
Application Details for Thursday, July 27, 2023
This page was updated on Friday, July 28, 2023 at 01:56 AM GMT
Department of Health and Human Services (HHS)
| US 20230232796 | Brydges et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regeneron Pharmaceuticals, Inc. (Tarrytown, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susannah Brydges (Scarsdale, New York); Christos Kyratsous (Irvington, New York); Alina Baum (Pleasantville, New York) |
| ABSTRACT | Non-human animal cells and non-human animals comprising a humanized ACE2 locus and methods of using such non-human animal cells and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized ACE2 locus express a human ACE2 protein or a chimeric ACE2 protein, fragments of which are from human ACE2. Methods are also provided for using such non-human animals comprising a humanized ACE2 locus to assess in vivo ACE2 activity, e.g., coronavirus infection and/or the treatment or prevention thereof. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 18/002228 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Original (OR) Class A01K 2207/15 (20130101) A01K 2217/072 (20130101) A01K 2227/105 (20130101) A01K 2267/0337 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0008 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) C12N 15/907 (20130101) Enzymes C12Y 304/17023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230232820 | WOODS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ossium Health, Inc. (San Francisco, California) |
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| INVENTOR(S) | Erik J. WOODS (Carmel, Indiana); Brian H. JOHNSTONE (Fishers, Indiana) |
| ABSTRACT | The present disclosure relates to, at least, a vacuum-assisted method for infiltrating cadaver bone with a cryoprotectant and a method for rapidly warming the cryopreserved cadaver bone for bone marrow processing. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155657 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) A01N 1/0284 (20130101) Original (OR) Class A01N 1/0289 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 5/0663 (20130101) C12N 2501/734 (20130101) C12N 2509/10 (20130101) C12N 2523/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233157 | Tichauer et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Tichauer (Chicago, Illinois); Robert W. Holt (Lebanon, New Hampshire); Frederic Leblond (Montreal, Canada); Pablo Valdes (Hanover, New Hampshire); Brian W. Pogue (Hanover, New Hampshire); Keith D. Paulsen (Hanover, New Hampshire); David W. Roberts (Lyme, New Hampshire) |
| ABSTRACT | A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/159495 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0035 (20130101) A61B 5/0062 (20130101) A61B 5/0071 (20130101) A61B 5/7278 (20130101) Original (OR) Class A61B 2576/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233321 | Lederman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, As Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Transmural Systems LLC (Andover, Massachusetts) |
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| INVENTOR(S) | Robert J. Lederman (Bethesda, Maryland); Christopher G. Bruce (Bethesda, Maryland); Morgan House (Andover, Massachusetts); Nasser Rafiee (Andover, Massachusetts) |
| ABSTRACT | The present disclosure provides embodiments of devices that are useful in the structural remodeling of various parts of the cardiovascular system, most notably the heart. Certain of the disclosed devices relate to RAMIN procedures (“remodeling and ablation using myocardial interstitial navigation”). RAMIN procedures, as described herein, represent a new family of non-surgical catheter-based procedures in order to accomplish ablation, drug delivery, re-shaping, pacing, and related structural heart interventional procedures, as desired. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/151601 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0215 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2442 (20130101) Original (OR) Class A61F 2210/0066 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0563 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233489 | Cheng et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feixiong Cheng (Cleveland, Ohio); Reena Mehra (Cleveland, Ohio); Sujata Rao (Cleveland, Ohio); Yadi Zhou (Cleveland, Ohio); Yuan Hou (Cleveland, Ohio) |
| ABSTRACT | The present invention provides methods, compositions, combinations, and kits for treating a subject with a viral infection (e.g., COVID-19) by administering or providing an estrogen receptor modulator and an anti-inflammatory agent or by administering or providing an anti-inflammatory agent (e.g., melatonin) to the subject. |
| FILED | Friday, June 18, 2021 |
| APPL NO | 18/001832 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/138 (20130101) Original (OR) Class A61K 31/4045 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233501 | HASTY et al. |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
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| INVENTOR(S) | Edward Paul HASTY (San Antonio, Texas); Dmitri Nickolaevich IVANOV (San Antonio, Texas) |
| ABSTRACT | Provided here are therapeutically effective pharmaceutical compositions containing one or more TREX2 inhibitors, and more specifically methods of administering TREX2 inhibitors to increase the effectiveness of a chemotherapeutic agent. Also provided here are methods of identifying agents that inhibit the exonuclease activity of TREX2. |
| FILED | Monday, March 27, 2023 |
| APPL NO | 18/126547 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/24 (20130101) Original (OR) Class A61K 31/53 (20130101) A61K 31/136 (20130101) A61K 31/192 (20130101) A61K 31/352 (20130101) A61K 31/405 (20130101) A61K 31/655 (20130101) A61K 49/0043 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233517 | Xue et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ding Xue (Louisville, Colorado); Yu Peng (Bejing, China PRC); Man Zhang (Beijing, China PRC); Lingjun Zheng (Boulder, Colorado); Qian Liang (Beijing, China PRC); Hanzeng Li (Louisville, Colorado); Jau-Song Yu (Taoyuan, Taiwan); Jeng-Ting Chen (Taoyuan, Taiwan) |
| ABSTRACT | The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/852475 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/336 (20130101) A61K 31/353 (20130101) Original (OR) Class A61K 31/4025 (20130101) A61K 31/7048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233531 | RUAN |
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| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ke-He RUAN (Bellaire, Texas) |
| ABSTRACT | The present disclosure provides use of non-steroidal anti-inflammatory compositions as described herein for used in the treatment of inflammation, inflammatory-related diseases, pain and/or fever. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/158717 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233532 | ROBERTSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gavin Peter ROBERTSON (Hummelstown, Pennsylvania); Shantu AMIN (Union City, New Jersey); Pingnain HE (Harrisburg, Pennsylvania); Arun SHARMA (Hummelstown, Pennsylvania); Yu-Chi CHEN (Hershey, Pennsylvania) |
| ABSTRACT | The present disclosure is directed to a compound or compositions comprising the same for decreasing vascular permeability and the prevention or inhibition of metastasis in a cancer. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 18/010690 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 9/1617 (20130101) A61K 31/4245 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233533 | LI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Health Research, Inc. (Menands, New York); The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Health Research, Inc. (Menands, New York); The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Hongmin LI (Tucson, Arizona); Zhong LI (Tucson, Arizona); Jia ZHOU (League City, Texas); Jimin XU (Galveston, Texas) |
| ABSTRACT | The present disclosure relates to a Prp8 intein splicing inhibitor. The present disclosure further relates to a method of treating and/or preventing a fungal infection, said method comprising administering a Prp8 intein splicing inhibitor under conditions effective to treat and/or prevent a fungal infection. Also disclosed is a method of inhibiting Prp8 intein expression or activity in a cell or tissue, said method comprising administering a compound under conditions effective to inhibit Prp8 intein expression or activity in a cell or tissue. Further disclosed are methods for screening for compounds that inhibit Prp8 intein splicing comprising an assay and a kit for predicting the likelihood of Prp8 inhibition. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 18/001316 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) Original (OR) Class A61K 31/433 (20130101) A61K 31/4439 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233535 | PATEL et al. |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
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| INVENTOR(S) | Preeyam S. PATEL (New York, New York); Robert J. SCHNEIDER (New York, New York) |
| ABSTRACT | Disclosed herein is a method of inhibiting T Follicular Helper (TFH) cell-mediated differentiation and/or activation in a subject. This method involves administering to a subject in need of treatment for an autoimmune disorder a eukaryotic translation initiation factor 4E (eIF4E) inhibitor to inhibit TFH cell-mediated differentiation and/or activation in the subject. Also disclosed is a method of inhibiting T Follicular Helper (THF) cell differentiation or TFH cell activity. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/165113 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233561 | LeBrasseur et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan K. LeBrasseur (Rochester, Minnesota); Marissa Joy Schafer (Rochester, Minnesota); Thomas A. White (Spring Valley, Minnesota); Elizabeth J. Atkinson (Rochester, Minnesota); Xu Zhang (Rochester, Minnesota) |
| ABSTRACT | Abstract: This document relates to methods and materials for assessing biological aging. For example, methods and materials that can be used to determine if a mammal (e.g., a human) has an advanced biological age, is at risk of developing one or more adverse outcomes (e.g., adverse outcomes associated with medical intervention at an advanced biological age) following a medical intervention, and/or is likely to be responsive to one or more senotherapeutic agents are provided herein. In some cases, methods and materials for using one or more senotherapeutic agents to improve one or more outcomes for a mammal following a medical intervention (e.g., surgery) are also provided. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 18/008758 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/352 (20130101) A61K 31/395 (20130101) A61K 31/436 (20130101) A61K 31/496 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/635 (20130101) A61K 31/4045 (20130101) A61K 38/1709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233563 | ROBICHAUX et al. |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jacqulyne ROBICHAUX (Houston, Texas); Monique NILSSON (Houston, Texas); John V. HEYMACH (Houston, Texas) |
| ABSTRACT | The present disclosure provides methods of treating cancer in a patient determined to have an EGFR and/or HER2 exon 20 mutation, such as an insertion mutation, by administering a third-generation tyrosine kinase inhibitor, such as poziotinib or afatinib. |
| FILED | Wednesday, August 24, 2022 |
| APPL NO | 17/821931 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233565 | STUMPFF |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VERMONT (Burlington, Vermont) |
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| INVENTOR(S) | Jason STUMPFF (Shelburne, Vermont) |
| ABSTRACT | The present application is directed to a method of inhibiting proliferation of chromosome instable cancer cells. This method involves administering, to a population of cancer cells comprising chromosome instable cancer cells, an inhibitor of Kinesin Family Member 18A (KIF18A) at a dosage effective to inhibit proliferation of said chromosome instable cancer cells. The inhibitors of KIF18A may also be used in a method treating cancer in a subject. This method involves selecting a subject having cancer, where the cancer is characterized by chromosomal instability, and administering to the subject an inhibitor of KIF18A at a dosage effective to treat the cancer in the subject. Also disclosed is a combination therapeutic including an inhibitor of Kinesin Family Member 18A (KIF18A) and agent that promotes microtubule turnover or a cyclin-dependent kinase (CDK) inhibitor. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/924809 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 31/357 (20130101) A61K 31/444 (20130101) A61K 31/475 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4545 (20130101) A61K 31/4745 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233566 | WANG et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Cun-Yu WANG (Los Angeles, California); Lingfei JIA (Los Angeles, California) |
| ABSTRACT | The present disclosure reports that pharmacological or genetic inhibition of Moloney murine leukemia virus insertion site 1 (BMI1) not only helped to eliminate BMI1+ cancer stem cells (CSCs), but can also augment PD1 blockade by strongly induced tumor cell-intrinsic immune responses by recruiting and activating CD8+ T cells. Taken together, the results indicate that in addition to purging CSCs, targeting BMI1 would enable immune checkpoint blockade to inhibit metastatic tumor growth and prevent tumor relapse by activating cell-intrinsic immunity. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/928767 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/497 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/4406 (20130101) A61K 33/243 (20190101) A61K 39/39533 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233590 | Zhou et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); Monash University (Clayton, Australia) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana); Monash University (Clayton, Victoria, Australia) |
| INVENTOR(S) | Qi Zhou (West Lafayette, Indiana); Maizbha Uddin Ahmed (West Lafayette, Indiana); Jian Li (Carnegie, Victoria, Australia); Mohammad Abul Kalam Azad (Melton South, Victoria, Australia) |
| ABSTRACT | The present disclosure generally relates to a method for reducing the toxicity of inhaled polymyxins as a therapeutic agent comprising the step of co-administration of an aminoglycoside; a method for improving the aerosolization of an aminoglycoside comprising the step of combination formulation with a polymyxin; and a process for manufacturing a dry powder composition comprising a polymyxin and aminoglycoside. Pharmaceutical compositions and methods of treatment for lung infections are within the scope of this invention. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 18/011155 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0075 (20130101) A61K 9/0078 (20130101) A61K 9/1682 (20130101) A61K 31/7036 (20130101) Original (OR) Class A61K 38/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233594 | Kraemer et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Kraemer (Kent, Washington); Jeanna M. Wheeler (Seattle, Washington); Pamela McMillan (Seattle, Washington); Timothy J. Strovas (Algona, Washington); Jeremy Baker (Seattle, Washington) |
| ABSTRACT | Described herein are compositions and methods for treating Alzheimer's disease or dementia. The compositions include mammalian suppressor of taupathy 2 inhibitors (MSUT2). The MSUT2 inhibitors can be small interfering RNAs, guide RNAs, or small molecules. The methods include reducing accumulation of phosphorylated and aggregated human tau. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/929867 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/26 (20130101) A61K 31/41 (20130101) A61K 31/713 (20130101) Original (OR) Class A61K 31/4745 (20130101) A61K 31/7105 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2740/15043 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233595 | NADLER et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York Medical College (Valhalla, New York) |
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| INVENTOR(S) | Jerry L. NADLER (Briarcliff Manor, New York); Patric K. Stanton (Mahopac, New York) |
| ABSTRACT | The present disclosure provides methods of treatment of multiple neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Dementia with Lewy Bodies, Frontotemporal dementia, Chronic Traumatic Encephalopathy, Diabetes, Cerebrovascular disease and Stroke based on the administration of STAT4 inhibitors. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/157305 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233607 | WANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingxiao WANG (San Diego, California); Ziliang HUANG (San Diego, California); Yiqian WU (San Diego, California) |
| ABSTRACT | In alternative embodiments, provided are compositions, including recombinant expression systems and vectors, products of manufacture and kits, and methods, for remotely-controlled and non-invasive manipulation of intracellular nucleic acid expression, genetic processes, function and activity in live cells such as T cells in vivo, for example, activating, adding functions or changing or adding specificities for immune cells, for monitoring physiologic processes, for the correction of pathological processes and for the control of therapeutic outcomes. In alternative embodiments, provided are blue-light-mediated light-inducible nuclear translocation and dimerization (LINTAD) systems for gene regulation to control cell activation based on the integration of light-sensitive LOV2-based nuclear localization, light-induced active transportation via the biLINuS motif, and CRY2-CIB1 dimerization that feature high spatiotemporal control to control or alter cell activities in vivo, for example, to limit CAR T cell activity to the tumor site for immunotherapy applications. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/800500 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/465 (20130101) A61K 2039/5156 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 2005/0663 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/00 (20130101) C07K 14/245 (20130101) C07K 14/4702 (20130101) C07K 14/4728 (20130101) C07K 14/7051 (20130101) C07K 14/7056 (20130101) C07K 14/70503 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/625 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2740/15043 (20130101) C12N 2800/80 (20130101) C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233620 | Fischbach et al. |
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| FUNDED BY |
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| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Federation Bio, Inc. (South San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. Fischbach (Stanford, California); Ariel R. Brumbaugh (San Francisco, California); Alice G. Cheng (San Francisco, California); Dylan Dodd (San Francisco, California); Andres Jesus Aranda-Diaz (San Francisco, California); Min Wang (San Francisco, California); Feiqiao Brian Yu (San Francisco, California); Justin L. Sonnenburg (San Francisco, California); Kerwyn C. Huang (San Francisco, California); Steve Higginbottom (San Francisco, California); Sunit Jain (San Francisco, California); Xiandong Meng (San Francisco, California); Lee Swem (Montara, California); Dante Ricci (Richmond, California); Joshua J. Hamilton (San Mateo, California) |
| ABSTRACT | The present invention provides high-complexity defined gut microbial communities capable of achieving substantial engraftment and having stability following human fecal community microbial challenge and methods of producing the same. Also provided are methods of using high-complexity defined gut microbial communities for the treatment of dysbiosis or a pathological condition in an animal. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/999516 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/741 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233645 | Hageman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory S. Hageman (Salt Lake City, Utah); Giuliana Silverstri (Belfast, United Kingdom); Paulina Haas (Vienna, Austria); Monika Fleckenstein (Bonn, Germany); Christian Matthew Pappas (Salt Lake City, Utah); Robin Guymer (Victoria, Australia) |
| ABSTRACT | Disclosed herein are methods and compositions for the diagnosis and treatment of Vascular Associated Maculopathy, or a symptom thereof, in a subject. Disclosed herein are methods and compositions for the diagnosis and treatment of one or more symptoms associated with Vascular Associated Maculopathy Disclosed in a subject. Disclosed herein are methods and compositions for the diagnosis and treatment of severe maculopathy or last stage maculopathy in a subject. Disclosed herein are methods and compositions for the diagnosis and treatment of resolving aberrant choriocapillaris lobules in a subject. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947492 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2217/052 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/015 (20130101) A61K 31/225 (20130101) A61K 31/4422 (20130101) A61K 38/005 (20130101) A61K 38/06 (20130101) A61K 38/07 (20130101) A61K 38/08 (20130101) A61K 38/1709 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233664 | Amara et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); Indian Institute of Science (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rama Rao Amara (Decatur, Georgia); Andrew Jones (Atlanta, Georgia); Raghavan Varadarajan (Bengaluru, India) |
| ABSTRACT | This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/158940 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class A61K 2039/53 (20130101) Peptides C07K 14/162 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233668 | Yantasee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| INVENTOR(S) | Wassana Yantasee (Lake Oswego, Oregon); Sherif Reda (Portland, Oregon); Moataz Reda (Portland, Oregon); Worapol Ngamcherdtrakul (Portland, Oregon); Ruijie Wang (Portland, Oregon) |
| ABSTRACT | Disclosed are immunogenic constructs including: a nanoparticle; a cationic polymer electrostatically bound to an exterior surface of the nanoparticle and a stabilizer bound to the cationic polymer or the exterior surface of the nanoparticle; and an antigen or antigen producing agent. Optionally, the constructs may include adjuvant and/or one or more functional oligonucleotide(s) (e.g., siRNA or pDNA). Also disclosed are methods of using the provided immunogenic constructs for co-delivering an adjuvant, antigen, and optionally siRNA to a cell, inducing immune response in a subject, and treating or preventing an infectious disease in a subject. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 18/003766 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 39/39 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 47/6923 (20170801) A61K 2039/6093 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233689 | Spiegel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); David Caianiello (New Haven, Connecticut); Mengwen Zhang (New Haven, Connecticut) |
| ABSTRACT | The present disclosure is directed to bifunctional small molecules which contain a circulating protein binding moiety (CPBM) linked through a linker group to a cellular receptor binding moiety (CRBM) which is a membrane receptor of degrading cell such as a hepatocyte or other degrading cell. In certain embodiments, the (CRBM) is a moiety which binds to asialoglycoprotein receptor (an asialoglycoprotein receptor binding moiety, or ASGPRBM) of a hepatocyte. In additional embodiments, the (CRBM) is a moiety which binds to a receptor of other cells which can degrade proteins, such as a LRP1, LDLR, FcγRI, FcRN, Transferrin or Macrophage Scavenger receptor. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/161712 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/54 (20170801) A61K 47/55 (20170801) A61K 47/64 (20170801) A61K 47/545 (20170801) Original (OR) Class A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233690 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shaomeng Wang (Superior Township, Michigan); Xin Han (Ann Arbor, Michigan); Weiguo Xiang (Ypsilanti, Michigan); Chong Qin (Ann Arbor, Michigan); Lijie Zhao (Ann Arbor, Michigan) |
| ABSTRACT | The present disclosure provides compounds represented by Formula I: A-L-B1 and the salts or solvates thereof, wherein A, L, and B1 are as defined in the specification. Compounds having Formula I are androgen receptor degraders useful for the treatment of cancer and other diseases. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 18/012267 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class A61K 47/545 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233691 | XIAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas); Tract Pharmaceuticals, Inc. (West Hartford, Connecticut) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); Tract Pharmaceuticals, Inc. (West Hartford, Connecticut) |
| INVENTOR(S) | Wa XIAN (Sugar Land, Texas); Frank MCKEON (Sugar Land, Texas); Shan WANG (Houston, Texas); Audrey-Ann LIEW (Houston, Texas); Matthew VINCENT (Amesbury, Massachusetts) |
| ABSTRACT | The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of esophageal tissue and gastric tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic Barrett's Esophagus stem cells (BESCs) or Gastric Intestinal Metaplasia stem cells (GIMSCs) relative to normal regenerative esophageal stem cells or gastric stem cells in the tissue in which the BESCs or GIMSCs are found. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 18/048773 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0024 (20130101) A61K 9/51 (20130101) A61K 9/0053 (20130101) A61K 31/5025 (20130101) A61K 47/55 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230233693 — POLY(AMINE-CO-ESTER) POLYMERS WITH MODIFIED END GROUPS AND ENHANCED PULMONARY DELIVERY
| US 20230233693 | Saltzman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | W. Mark Saltzman (New Haven, Connecticut); Yuhang Jiang (New Haven, None); Molly Grun (New Haven, Connecticut); Alexandra Suberi (New Haven, Connecticut) |
| ABSTRACT | Poly(amine-co-ester) polymers, methods of forming active agent-load polyplexes and particles therefrom, and methods of using them for delivery of nucleic acid agents with optimal uptake have been developed. Examples demonstrate critical molecular weights in combination with exposed carboxylic and/or hydroxyl groups, and methods of making. Typically, the compositions are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the compositions are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition. For poly(amine-co-ester) polymers with specific amine or hydroxyl group containing end-groups in admixture with PEGylated poly(amine-co-ester) polymers, in vivo delivery to the lung by inhalation has been shown. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 18/002241 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/593 (20170801) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/916 (20130101) C08G 63/6856 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233701 | Pishesha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Novalia Pishesha (Boston, Massachusetts); Hidde L. Ploegh (Boston, Massachusetts); Thibault Harmand (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are compositions comprising VHH conjugates and their uses in treating diseases. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 18/007638 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/0008 (20130101) A61K 47/65 (20170801) A61K 47/6811 (20170801) Original (OR) Class A61K 47/6849 (20170801) A61K 2039/6056 (20130101) A61K 2039/55516 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233704 | RADISIC et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Quthero, Inc. (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milica RADISIC (Toronto, Canada); Yun XIAO (Toronto, Canada); Lewis REIS (Toronto, Canada); Serena MANDLA (Toronto, Canada) |
| ABSTRACT | The invention provides a composition and pharmaceutical formulation including a peptide immobilized in a hydrogel. Compositions and formulations of the invention are useful in reducing the size, severity or duration of a wound, ameliorating of one or more symptoms associated with a wound without necessarily curing the wound or lessening in the growth or severity of a wound, skin irritation or skin inflammation. Compositions and formulations of the invention are particularly useful in the treatment of skin irritation, skin inflammation, and a wound associated with diabetes, such as a diabetic ulcer. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/170979 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 47/6903 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Peptides C07K 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233706 | Parhiz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hamideh Parhiz (Philadelphia, Pennsylvania); Drew Weissman (Philadelphia, Pennsylvania); Istvan Tombacz (Philadelphia, Pennsylvania); Norbert Pardi (Philadelphia, Pennsylvania); Vladimir Muzykantov (Bryn Athyn, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions comprising a delivery vehicle conjugated to a targeting domain, wherein the delivery vehicle comprises at least one agent, and wherein the targeting domain specifically binds to an CD4+ T cell antigen. The invention also relates to methods of treating or preventing diseases and disorders, including cancers, infectious diseases, and immunological disorders, using the described compositions. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/906792 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/549 (20170801) A61K 47/6849 (20170801) A61K 47/6929 (20170801) Original (OR) Class A61K 48/0033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233712 | BAHOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Wadie F. BAHOU (Setauket, New York); Song WU (Stony Brook, New York) |
| ABSTRACT | The present disclosure provides methods of treating a human having a disease or disorder that would benefit from increasing platelet counts. The method involves inhibiting the enzyme activity of biliverdin IXβ reductase (BLVRB) activity or inhibiting the expression of BLVRB gene. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/174793 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 35/19 (20130101) A61K 48/0016 (20130101) A61K 48/0066 (20130101) Original (OR) Class A61K 48/0083 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) Enzymes C12Y 103/01024 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233715 | Hopkins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of The University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Hopkins (Sylvania, Ohio); Scott D. Swanson (Ann Arbor, Michigan); Raoul Kopelman (Ann Arbor, Michigan) |
| ABSTRACT | A targetable nanoconstruct capable of simultaneously serving as a therapeutic platform for photodynamic therapy as well as an MR molecular imaging agent, free of heavy metal atoms. F3-cys targeting agent nanoconstructs, including 8PEGA-Ce6 NCs. A label-free 8PEGA nanoconstruct that can be directly and selectively imaged by MRI, using standard spin-echo imaging sequences with large diffusion magnetic field gradients to suppress the water signal. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/151246 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/1818 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233738 | Roberts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan Roberts (Raleigh, North Carolina); Ashutosh Cilkoti (Durham, North Carolina); Bruce Klitzman (Littleton, North Carolina); Scott Hollenbeck (Durham, North Carolina) |
| ABSTRACT | Described herein are compositions and method for autologous adipose tissue grafting. In one embodiment, the composition comprises a recombinant partially ordered polypeptide (Fractomer) or “Fractomer” and adipose tissue from a subject. In one aspect, the Fractomer has the general structure of [(GXGVP)n-α-helix]m, where X can be any amino acid except proline and α-helix is any polyalanine based α-helix having about 5 to 50 Alanine residues. In another aspect, the Fractomer has the structure [(GXGVP)n-GX1(A)25X1]m; where X is A or V; X1 is K or D; n is an integer from 10 to 20; and m is an integer from 4 to 8. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/007879 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/227 (20130101) A61L 27/3604 (20130101) Original (OR) Class A61L 2300/22 (20130101) A61L 2300/252 (20130101) Peptides C07K 14/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233860 | Sarma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Sridevi V. Sarma (McLean, Virginia); Yun Guan (Baltimore, Maryland); Claire Zurn (Baltimore, Maryland); Christine Beauchene (Chantilly, Virginia) |
| ABSTRACT | A closed-loop implantable neurostimulator system for mitigating chronic pain, the closed-loop implantable neurostimulator system including a neuromodulation device comprising one or more electrodes configured to measure a physiological signal of a subject and deliver an electrical stimulation signal to a target area in the subject and a controller, in communication with the one or more electrodes, comprising a processor and a computer-readable memory storing a trained healthy computer model, the controller configured to analyze the physiological signal that is measured using the trained healthy computer model to identify a corrective electrical stimulation signal that, when delivered by the one or more electrodes to the target area, reduces pathological neuronal events in the target area while preserving acute pain response. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 18/002119 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101) A61N 1/36071 (20130101) A61N 1/36139 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233872 | Moore-Ede et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Korrus, Inc. (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Christopher Moore-Ede (Wellesley, Massachusetts); Rebecca Mary Chacko (Brookline, Massachusetts); Anneke Marlies Heitmann (Arlington, Massachusetts); Robert Frederic Casper (Toronto, Canada); Robert Frank Karlicek, JR. (Clifton, New York); Doros Platika (Pittsburgh, Pennsylvania); Udo Trutschel (Tabarz, Germany) |
| ABSTRACT | Lighting systems, methods, and devices for protecting human circadian neuroendocrine function during night use are described. Suitable lighting conditions can be provided for a working environment while protecting the circadian neuroendocrine systems of those occupying the illuminated workplace during the night. Lighting systems, methods, and devices can provide substantive attenuation of the pathologic circadian disruption in night workers. Lighting systems, methods, and devices can attenuate the specific bands of light implicated in circadian disruption. LED lighting systems, methods, and devices can provide increased intensity at a different portion of the spectrum than conventional LEDs, providing a useable white light even when unfavorable portions of the wavelength are attenuated by a notch filter. LED lighting systems, methods, and devices can switch between a daytime configuration and a night time configuration, wherein the daytime configuration provides unfiltered light and the night time configuration provides filtered light. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/108959 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 21/00 (20130101) A61M 2021/0044 (20130101) A61M 2205/50 (20130101) A61M 2205/3368 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 5/0618 (20130101) Original (OR) Class A61N 2005/0636 (20130101) A61N 2005/0652 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/592 (20130101) C09K 11/621 (20130101) Indexing Scheme Associated With Subclasses F21K, F21L, F21S and F21V, Relating to the Form or the Kind of the Light Sources or of the Colour of the Light Emitted F21Y 2105/00 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 45/20 (20200101) H05B 47/16 (20200101) H05B 47/155 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234046 | Schaus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas E. Schaus (Cambridge, Massachusetts); Nikhil Gopalkrishnan (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts) |
| ABSTRACT | A device for performing an assay comprises a tube, a cap, an insert, and a reaction container. The tube includes a lateral flow strip disposed therein. The cap is coupled to the tube and includes a hollow interior defined at least partially therethrough. The insert is configured to be at least partially received within the hollow interior of the cap. The reaction container includes a cavity configured to store one or more fluids therein, and is rotatably coupled to the cap such that rotation of the cap relative to the reaction container causes (i) mixing of the one or more fluids and (ii) at least a portion of the mixed fluids to be delivered from the reaction container to the lateral flow strip via the insert. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 18/002629 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) Original (OR) Class B01L 3/5029 (20130101) B01L 3/50825 (20130101) B01L 3/502715 (20130101) B01L 2200/16 (20130101) B01L 2200/0689 (20130101) B01L 2300/18 (20130101) B01L 2300/042 (20130101) B01L 2300/0825 (20130101) B01L 2300/0877 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54388 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234051 | BROUZES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| INVENTOR(S) | Eric BROUZES (Port Jefferson, New York); Martin SAUZADE (Setauket, New York) |
| ABSTRACT | A microfluidic device is disclosed which comprises a main flow channel and a partition chamber connected to a portion of same by a chamber inlet and chamber outlet. The device utilizes select cross sections to advantage capillary effects during filling and partitioning steps to isolate biological or other samples in the partition chamber for analysis and can be employed in a digital array. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/008590 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2300/12 (20130101) B01L 2300/0838 (20130101) B01L 2300/0861 (20130101) B01L 2400/0406 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234215 | Zelik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl E. Zelik (Nashville, Tennessee); Michael Goldfarb (Nashville, Tennessee); Paul R. Slaughter (Nashville, Tennessee); Shane T. King (Nashville, Tennessee); Cameron A. Nurse (Nashville, Tennessee); Chad C. Ice (Nashville, Tennessee) |
| ABSTRACT | A clutch mechanism includes a spool that is configured to receive a cable, a disk with elasticity, a mechanism configured for locking and unlocking the movement of the disk, and at least one sensor. The at least one sensor being configured to measure the movement of at least one of the disk and the spool in the unlocked mode and to measure the movement of the spool relative to the disk when in a locked mode. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/157317 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) Original (OR) Class B25J 9/104 (20130101) B25J 13/088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234923 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinkun Chen (Lexington, Massachusetts); Qisheng Tu (Newton, Massachusetts); Xingwen Wu (Boston, Massachusetts); Gang Chen (Shanghai, China PRC); Wei Qiu (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are adiponectin receptor agonists and methods of using the same for the treatment of inflammation or bone loss in a subject. |
| FILED | Wednesday, April 12, 2023 |
| APPL NO | 18/299266 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) A61P 29/00 (20180101) Heterocyclic Compounds C07D 211/58 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234931 | RUAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ke-He RUAN (Bellaire, Texas) |
| ABSTRACT | The disclosure provides 2-amino 4-nitrophenol and 2,4-diaminophenol derivatives, which can be used as anti-inflammatory drugs, prostaglandin E2 (PGE2) synthesis and activity inhibitors, and microsomal PGE2 synthase-1 (mPGES-1) inhibitors. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/158670 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Heterocyclic Compounds C07D 263/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234935 | DEVITA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert J. DEVITA (New York, New York); Chalada SUEBSUWONG (New York, New York); Kunal KUMAR (New York, New York); Roberto J. SANCHEZ (New York, New York); Andrew F. STEWART (New York, New York); Peng WANG (New York, New York); Michael B. LAZARUS (New York, New York) |
| ABSTRACT | Disclosed herein are kinase inhibitor compounds having the structure (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, X, L, Q, and Y are as defined herein. Also disclosed are compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 18/003088 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 213/74 (20130101) C07D 401/04 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 413/10 (20130101) C07D 413/12 (20130101) C07D 417/04 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235027 | Brody et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Brody (Bethesda, Maryland); Thomas J. Esparza (Frederick, Maryland) |
| ABSTRACT | The invention generally relates to VHH domains that specifically bind a severe acute respiratory syndrome coronavirus spike protein receptor binding domain, corresponding expression vectors and host cells, and methods of treatment using such VHH domains. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 18/011767 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Preparations for Medical, Dental, or Toilet Purposes A61K 2039/54 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235029 | Aman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Integrated Biotherapeutics, Inc. (Rockville, Maryland); University of Maryland, College Park (Rockville, Maryland); University of Maryland, Baltimore (Baltimore, Maryland); La Jolla Institute for Immunology (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Javad Aman (Rockville, Maryland); Yimeng Wang (Rockville, Maryland); Shweta Kailasan (Rockville, Maryland); Xuelian Zhao (Gaithersburg, Maryland); Andrey Galkin (Germantown, Maryland); Katie A. Howell (Rockville, Maryland); Erica Ollmann Saphire (La Jolla, California); Yuxing Li (Boyds, Maryland) |
| ABSTRACT | Disclosed herein is a novel class of isolated binding molecules including monoclonal antibodies that targets a broadly conserved epitope within the marburgvirus species. Certain aspects provide an effective treatment option for hemorrhagic fever caused by marburgviruses. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 18/016930 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54386 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235030 | Goodman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Institute at Nationwide Children's Hospital (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven D. Goodman (Hilliard, Ohio); Lauren O. Bakaletz (Hilliard, Ohio) |
| ABSTRACT | This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics. |
| FILED | Tuesday, February 14, 2023 |
| APPL NO | 18/168824 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/46 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 39/40 (20130101) A61K 39/0208 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/12 (20130101) C07K 16/40 (20130101) C07K 16/1232 (20130101) C07K 16/1242 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/6893 (20130101) G01N 33/56911 (20130101) G01N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235034 | Gibbons et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Garrett S. Gibbons (Philadelphia, Pennsylvania); Dawn M. Riddle (Philadelphia, Pennsylvania); John Q. Trojanowski (Philadelphia, Pennsylvania); Virginia M.Y. Lee (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides monoclonal antibodies that selectively bind to pathological tau over native tau. In certain aspects, the antibodies inhibit or minimize propagation of tau aggregates and/or reduce spread of pathological tau in vivo. In other aspects, the disclosure comprises a method of treating, ameliorating, and/or preventing a tauopathy in a subject, comprising administering any one of the antibodies of the disclosure to the subject. In yet other aspects, the disclosure comprises methods of detecting pathological tau using any one of the antibodies of the disclosure. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/999822 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235036 | Akassoglou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katerina Akassoglou (San Francisco, California); Mark Petersen (North Vancouver AB, Canada) |
| ABSTRACT | Compositions and methods to treat or prevent neurodegeneration in a mammal comprising administering to the mammal in need thereof an effective amount of an inhibitor of ACVR1 (Alk2). |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/008324 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235044 | McNally et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IKAIKA THERAPEUTICS, INC. (Oak Park, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth McNally (Oak Park, Illinois); Ahlke Heydemann (Oak Park, Illinois); Ermelinda Ceco (Chicago, Illinois) |
| ABSTRACT | The disclosure relates to compositions and methods of mitigating tissue damage and fibrosis in a patient by modulating latent transforming growth factor beta binding protein (LTBP4)-induced proteolysis of a TGFβ superfamily protein. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/811233 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) A61K 39/3955 (20130101) A61K 39/39533 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 7/08 (20130101) C07K 16/18 (20130101) C07K 16/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235065 | Wu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cancure, LLC (Shoreline, Washington) |
| ASSIGNEE(S) | Cancure, LLC (Shoreline, Washington) |
| INVENTOR(S) | Jennifer Wu (Wilmette, Illinois) |
| ABSTRACT | The present invention provides MIC antibodies, antigen binding portions thereof and MIC binding agents thereof for use in the treatment of cancer. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049434 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2833 (20130101) Original (OR) Class C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235066 | DIMITROFF et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHARLES J. DIMITROFF (CORAL GABLES, Florida); ASMI CHAKRABORTY (BOSTON, Massachusetts) |
| ASSIGNEE(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (MIAMI, Florida) |
| INVENTOR(S) | CHARLES J. DIMITROFF (CORAL GABLES, Florida); ASMI CHAKRABORTY (BOSTON, Massachusetts) |
| ABSTRACT | The present invention provides methods for diagnosis, prognosis, prevention and/or treatment of cancers such as melanomas. The subject invention provides biomarkers and methods for assessing the severity of a cancer/tumor and for monitoring the progressing of a cancer/tumor. The subject invention also provides therapeutic targets in cancer for developing anti-cancer therapies. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/101285 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2851 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235078 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
| INVENTOR(S) | Ningyan ZHANG (Houston, Texas); Zhiqiang AN (Houston, Texas); Hui DENG (Houston, Texas); Xiujie SUN (Washington, District of Columbia); Rong LI (Washington, District of Columbia) |
| ABSTRACT | The present disclosure relates to antibodies binding to tumor discoidin domain receptor 1 (DDR1) and the uses of the antibodies in detecting and treating cancer. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/176072 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/20 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235084 | KANNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott KANNER (New York, New York); Henry M. COLECRAFT (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, bivalent nanobody molecules and methods for treating or ameliorating the effects of a disease, such as long QT syndrome, or cystic fibrosis, in a subject, using the bivalent nanobody molecules disclosed herein. Also provided are methods of identifying and preparing nanobody binders that target proteins of interest. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/864389 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 16/28 (20130101) C07K 16/40 (20130101) Original (OR) Class C07K 2317/35 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235087 | Santich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian H. Santich (New York, New York); Nai-Kong V. Cheung (New York, New York); Mahiuddin Ahmed (New York, New York) |
| ABSTRACT | The present technology relates to the use of protein conjugates including a self-assembly and disassembly (SADA) polypeptide and a GD2-specific antigen binding domain for preventing or mitigating off-target tissue toxicity, such as brain, kidney, and/or myeloid damage, in a subject undergoing targeted alpha radioimmunotherapy. Also disclosed herein are pretargeted radioimmunotherapy (PRIT) methods that improve the durability of the anti-GD2-SADA conjugate anti-tumor response in vivo. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/999786 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0482 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 39/04 (20180101) Peptides C07K 16/44 (20130101) Original (OR) Class C07K 16/3084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235109 | APPEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric A. APPEL (Palo Alto, California); Caitlin MAIKAWA (Boston, Massachusetts); Joseph L. Mann (Mountain View, California) |
| ABSTRACT | A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/129811 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 9/5146 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235280 | Johannesson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York Stem Cell Foundations, Inc. (New York, New York) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Bjarki Johannesson (New York, New York); Deepta Bhattacharya (Tucson, Arizona); Hannah Pizzato (Tucson, Arizona) |
| ABSTRACT | The present invention provides modified stem cells (SCs) and use of the SCs to treat disease. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/768146 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/102 (20130101) C12N 2501/599 (20130101) C12N 2506/02 (20130101) C12N 2510/00 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235284 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark M. Davis (Atherton, California); Lisa E. Wagar (Santa Ana, California) |
| ABSTRACT | Disclosed herein are methods, systems and devices to model adaptive immune responses and develop and/or test improved antibodies, vaccines, and other therapeutic agents. The adaptive immune responses can be modeled using lymphoid tissue derived from a subject. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/094851 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/5154 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) C12N 5/0636 (20130101) C12N 5/0639 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235285 | Bauer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Children's Medical Center Corporation (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Children's Medical Center Corporation (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Daniel E. Bauer (Cambridge, Massachusetts); Stuat H. Orkin (Brookline, Massachusetts); Neville Sanjana (New York, New York); Ophir Shalem (Albany, California); Feng Zhang (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are nucleic acid molecules that target the BCL11A enhancer functional regions, compositions comprising the nucleic acid molecules and methods for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels. In particular, the nucleic acid molecules target the +62, +58, and/or the +55 enhancer functional regions. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/148886 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0641 (20130101) Original (OR) Class C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/102 (20130101) C12N 2310/20 (20170501) C12N 2510/00 (20130101) C12N 2740/15041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235301 | Ricciardi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert P. Ricciardi (Kennett Square, Pennsylvania); Manunya Nuth (Green Lane, Pennsylvania); Hancheng Guan (Downingtown, Pennsylvania); Richard W. Scott (West Chester, Pennsylvania); Michael H. Parker (Chalfont, Pennsylvania); Allen B. Reitz (Lansdale, Pennsylvania) |
| ABSTRACT | The present disclosure relates generally to stapled peptides, and pharmaceutical compositions thereof, which are useful for preventing and/or treating herpes simplex virus-1 (HSV-1) processive DNA synthesis, propagation, and/or infection in a subject. The present disclosure further provides methods for treating herpes simplex keratitis in a subject |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 18/000644 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 38/45 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) Original (OR) Class Enzymes C12Y 207/07007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235309 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Michelle Richter (Cambridge, Massachusetts); Kevin Tianmeng Zhao (Cambridge, Massachusetts); Benjamin Thuronyi (Cambridge, Massachusetts); Gregory Newby (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides adenine base editors (ABEs) that are variants of known adenine base editors. The adenosine deaminase domain of a known ABE was modified to produce adenosine deaminase variants. The deaminase variants provided herein have broader compatibility with diverse napDNAbp domains, such as Cas homologs, for base editing applications. The ABEs provided herein comprise a deaminase variant and a napDNAbp domain. The ABEs provided herein exhibit reduced off-target editing effects while retaining high on-target editing efficiencies. These ABEs exhibit reduced off-target DNA editing effects and reduced off-target editing effects in cellular mRNA. In addition, methods for targeted nucleic acid editing are provided. Further provided are pharmaceutical compositions comprising the ABEs. Also provided are vectors and kits useful for the generation and delivery of the ABEs, including vector systems for engineering the ABEs through directed evolution. Cells containing such vectors and ABEs are also provided. Further provided are methods of treatment comprising administering the ABEs. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/797701 |
| CURRENT CPC | Peptides C07K 2319/09 (20130101) C07K 2319/80 (20130101) C07K 2319/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/78 (20130101) Original (OR) Class C12N 15/102 (20130101) Enzymes C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235316 | Takebe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Takanori Takebe (Cincinnati, Ohio); Masaki Kimura (Cincinnati, Ohio) |
| ABSTRACT | Disclosed herein are insulin resistance reporters for use in quantifying insulin response in biological cells. These biological cells may be stem cell compositions or derivatives thereof comprising the insulin resistance reporter. The stem cell derivatives include but are not limited to insulin responsive cells, tissues, or organoids, such as pancreatic, brain, adipose, muscle, or liver cells, or tissues or organoids thereof. Also disclosed herein are methods of using said insulin resistance reporters and cells with these insulin resistance reporters as models to examine insulin resistance and screening for compounds that are potentially useful for the treatment of diseases or disorders associated with insulin resistance. The cells comprising an insulin resistance reporter may be hepatic cells or liver organoid compositions, which can be used in investigating hepatic insulin resistance, for example, as a result of non-alcoholic fatty liver disease or steatohepatitis. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/003130 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1055 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235320 | TROLL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CLARET BIOSCIENCE, LLC (Santa Cruz, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. TROLL (Santa Cruz, California); Varsha RAO (Santa Cruz, California) |
| ABSTRACT | The technology relates in part to methods and compositions for analyzing nucleic acid. In some aspects, the technology relates to methods and compositions for preparing a nucleic acid library from single-stranded nucleic acid fragments. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 18/011271 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Original (OR) Class C12N 2330/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6813 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235325 | Davidson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Children's Hospital of Philadelphia (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beverly L. Davidson (North Liberty, Iowa); Alejandro Mas Monteys (Philadelphia, Pennsylvania); Shauna Ebanks (Claymont, Delaware) |
| ABSTRACT | Compositions and methods are provided for the inhibition, treatment and/or prevention of Huntington's disease and related disorders. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938857 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/66 (20130101) C12N 15/88 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/861 (20130101) C12N 2310/20 (20170501) C12N 2330/51 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235334 | Weiss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ron Weiss (Newton, Massachusetts); Ross D. Jones (Cambridge, Massachusetts); Jin Huh (Watertown, Massachusetts) |
| ABSTRACT | Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. The cell state classifiers of the present disclosure utilize phosphorylation state of a transcription factor to control classifier output. Kinases and phosphatase pairs that function in phosphorylating or dephosphorylating the transcription factor are integrated into the circuit, their expression tuned by the presence of microRNAs of interest (e.g., in a cell). The genetic circuits and cell state classifiers may be used in various applications (e.g., therapeutic or diagnostic applications). |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811593 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/52 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 2600/112 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235339 | ROMESBERG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Floyd E. ROMESBERG (La Jolla, California); Denis A. MALYSHEV (La Jolla, California) |
| ABSTRACT | A recombinantly expressed nucleotide triphosphate transporter efficiently imports the triphosphates of unnatural nucleotides into cells, and the endogenous cellular machinery incorporates those nucleotides into cellular nucleic acids. UBPs can therefore form within the cell's nucleic acids. Moreover, neither the presence of the unnatural triphosphates nor the replication of the UBP represents a significant growth burden. The UBP is not efficiently excised by nucleic acid repair pathways, and therefore can be retained as long as the unnatural triphosphates are available in the growth medium. Thus, the resulting cell is the first organism to stably propagate an expanded genetic alphabet. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/881471 |
| CURRENT CPC | Peptides C07K 14/295 (20130101) C07K 14/405 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) Original (OR) Class C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235348 | Martienssen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York); Cambridge Enterprise Limited (Cambridge, United Kingdom) |
| ASSIGNEE(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York); Cambridge Enterprise Limited (Cambridge, United Kingdom) |
| INVENTOR(S) | Robert Martienssen (Cold Spring Harbor, New York); Charles Underwood (Cold Spring Harbor, New York); Ian Henderson (Cambridge, United Kingdom) |
| ABSTRACT | The present disclosure provides methods for increasing meiotic recombination in crop plants, as well as plants and seeds produced by such methods. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/813577 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/8218 (20130101) C12N 15/8261 (20130101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 40/146 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235374 | Cooperman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barry S. Cooperman (Philadelphia, Pennsylvania); Mikel D. Ghelfi (Philadelphia, Pennsylvania) |
| ABSTRACT | Disclosed are systems and methods for high throughput screening to detect translation readthrough induced drugs (TRID). The systems use highly purified, eukaryotic cell-free protein synthesis systems that distinguish TRIDs acting directly on the protein synthesis machinery from those that act indirectly. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/821055 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235394 | HACOHEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Nir HACOHEN (Boston, Massachusetts); THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nir HACOHEN (Boston, Massachusetts); Aziz AL'KHAFAJI (Cambridge, Massachusetts); Paul BLAINEY (Cambridge, Massachusetts); Mehrtash BABADI (Cambridge, Massachusetts); Kiran V GARIMELLA (Cambridge, Massachusetts); Jonathan Theodore SMITH (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods for nucleic acid sequencing, and specifically, at least in certain aspects, provides methods and compositions for enhancing the efficacy, throughput and/or yield of known long-range sequencing platforms, by providing chimeric arrays of input sequences. Such arrays of component nucleic acid sequence elements can be prepared via methods that minimize introduction of bias. The application of the current methods to obtain isoform sequencing information, e.g., from patient samples is specifically also provided, as are methods for mitochondrial lineage tracing that employ the instant chimeric amplicon sequencing processes. Methods and systems for array nucleic acid sequence processing and interpretation are also provided. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 18/001649 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235400 | Mootha et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vamsi Mootha (Boston, Massachusetts); Vijay Sankaran (Boston, Massachusetts); Caleb Lareau (Cambridge, Massachusetts); Melissa Walker (Boston, Massachusetts); Leif Ludwig (Cambridge, Massachusetts); Aviv Regev (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are methods of determining segregation dynamics of mitochondrial DNA herein. Also described herein are methods of diagnosing, prognosing, and/or monitoring a mitochondrial disease. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/928696 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235401 | Brody et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerome S. Brody (Boston, Massachusetts); Avrum Spira (Newton, Massachusetts); Jennifer E. Beane-Ebel (Fort Collins, Colorado); Marc E. Lenburg (Brookline, Massachusetts) |
| ABSTRACT | Sensitive biomarker(s) to identify individuals with past exposure to tobacco smoke based on gene expression are disclosed. Such biomarkers may be used, for example, for epidemiological studies related to smoke exposure, to provide insights into the mechanisms leading to reversible and persistent effects of tobacco smoke that may explain former smokers’ increased risk for developing tobacco-induced lung disease, and/or to provide novel targets for chemoprophylaxis. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940776 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235404 | Murphy et al. |
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| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barbara Murphy (Pelham Manor, New York); Weijia Zhang (Cresskill, New Jersey) |
| ABSTRACT | Disclosed herein are methods for diagnosing acute cellular rejection (ACR) of an allograft by analysis of predictive gene sets and kits for practicing these methods. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/165124 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/365 (20130101) A61K 31/436 (20130101) A61K 31/573 (20130101) A61K 38/13 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235411 | Straus |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | First Light Diagnostics, Inc. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Don Straus (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides systems and methods for rapid automated identification of microbes and antimicrobial susceptibility testing (AST) directly from a patient specimen, without specimen preparation. Specimens are loaded into an analytical cartridge for processing. Analytical cartridges are preloaded with species-specific labels that are used to identify and enumerate microbes in the specimen. Instruments, such as analyzers can be used to interact with analytical cartridges to carry out methods of the invention all within the cartridge. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282633 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/20 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6841 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236092 | Cui |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meng Cui (West Lafayette, Indiana) |
| ABSTRACT | Apparatuses for cutting tissue include an oscillator assembly and a clamp. The oscillator assembly defines a resonance frequency and includes a frame, an excitation element, and a blade. The frame has an upper portion and a lower portion, and the lower portion is configured to oscillate relative to the upper portion. The excitation element is coupled with the lower portion of the frame, and the excitation element is selectively operable to provide an excitation signal to the oscillator assembly sufficient to cause the oscillator assembly to oscillate at the resonance frequency. The blade is coupled with the lower portion for sectioning tissue. The clamp is selectively moveable along the frame to alter the resonance frequency of the oscillator assembly. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957678 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/06 (20130101) Original (OR) Class G01N 2001/063 (20130101) G01N 2001/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236171 | Zernicka-Goetz et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Cambridge Enterprise Limited (Cambridge, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Magdalena D. Zernicka-Goetz (Pasadena, California); Gianluca Amadei (Cambridge, United Kingdom); Charlotte Handford (Cambridge, United Kingdom) |
| ABSTRACT | Disclosed herein include methods and compositions for culture medias for in vitro culture of synthetic embryos from mammalian pluripotent stem cells and extra-embryonic stem cells. The methods and compositions described herein can generate synthetic embryos at different developmental stage reaching early organogenesis and beyond. Disclosed herein also include an embryo culturing system and methods of using same. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/065480 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0604 (20130101) C12N 2501/119 (20130101) C12N 2506/025 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236193 | IVERSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tina IVERSON (Nashville, Tennessee); Barbara BENSING (San Francisco, California); Paul SULLAM (San Francisco, California) |
| ABSTRACT | Disclosed are compositions and methods related to the use of sialoglycan as markers for the diagnosis and prognosis of cancers and inflammatory conditions. In one aspect, also disclosed herein are engineered probes and chimeric probes with differential binding ability to sialoglycans. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/009956 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/535 (20130101) G01N 33/57484 (20130101) Original (OR) Class G01N 2440/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236207 | Rahman et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Irfan Rahman (Rochester, New York); Matthew McGraw (Rochester, New York) |
| ABSTRACT | The present invention generally relates to novel biomarkers and their methods of use for identifying and treating e-cigarette, or vaping, product use-associated lung injury (EVALI). |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/158768 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236271 | Fessler et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Allen Fessler (Ann Arbor, Michigan); Douglas Clair Noll (Ann Arbor, Michigan); Guanhua Wang (Ann Arbor, Michigan) |
| ABSTRACT | The following relates generally to accelerated magnetic resonance imaging (MRI) reconstruction. In some embodiments, a MRI machine learning algorithm is trained based on reference MRI data in non-Cartesian k-space. During the training, at each iteration of a plurality of iterations: (i) a non-Cartesian sampling trajectory ω may be optimized under the physical constraints, and/or (ii) an image reconstructor may be jointly iteratively optimized. Examples of the image reconstructor include a convolutional neural network (CNN) denoiser, a model-based deep learning (MoDL) image reconstructor, iterative image reconstructor, a regularizer, and an invertible neural network. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/097632 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4826 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/20 (20130101) G06T 11/008 (20130101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230236272 — Deep learning-based water-fat separation from dual-echo chemical shift encoded imaging
| US 20230236272 | Vasanawala et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shreyas S. Vasanawala (Stanford, California); Yan Wu (Mountain View, California) |
| ABSTRACT | A method for magnetic resonance imaging performs chemical shift encoded imaging to produce complex dual-echo images which are then applied (with imaging parameters) as input to a deep neural network to produce as output water-only and fat-only images. The deep neural network can be trained with ground truth water/fat images derived from chemical shift encoded images using a conventional water-fat separation algorithm such as projected power approach, IDEAL, or VARPRO. The chemical shift encoded imaging comprises performing an image acquisition with the MRI scanner via a spoiled-gradient echo sequence or a spin-echo sequence. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/102249 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/485 (20130101) Original (OR) Class G01R 33/4828 (20130101) Image Data Processing or Generation, in General G06T 11/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236274 | Ning et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lipeng Ning (Belmont, Massachusetts); Yogesh Rathi (Lexington, Massachusetts); Yang Ji (Brighton, Massachusetts); Borjan Gagoski (Cambridge, Massachusetts) |
| ABSTRACT | Scan time in diffusion-relaxation magnetic resonance imaging (“MRI”) is reduced by implementing time-division multiplexing (TDM). In general, time-shifted radio frequency (“RF”) pulses are used to excite two or more imaging volumes. These RF pulses are applied to induce separate echoes for each slice. Diffusion MRI data can thus be acquired with different echo times, or alternatively with the same echo time, in significantly reduced overall scan time. Multidimensional correlations between diffusion and relaxation parameters can be estimated from the resulting data. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 18/008077 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/4818 (20130101) G01R 33/5617 (20130101) Original (OR) Class G01R 33/56341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237618 | Forouhesh-Tehrani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board Of Trustees of the University of lllinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kayvan Forouhesh-Tehrani (Urbana, Illinois); Stephen A. Boppart (Champaign, Illinois) |
| ABSTRACT | Super-resolution label-free microscopy is provided using multiplexed, temporally modulated acquisition patterns of emission point spread functions (“PSFs”). Supercontinuum ultrafast pulses can be used to enhance nonlinear processes, such as autofluorescence and harmonic generation, in order to provide super-resolution imaging of nonlinear label-free signals. Images can be reconstructed using various reconstruction techniques, including pixel reassignment, wavelet reconstruction, and deep learning model-based reconstructions. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/160020 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4053 (20130101) Original (OR) Class G06T 5/50 (20130101) G06T 2207/10056 (20130101) G06T 2207/20084 (20130101) G06T 2207/20212 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237660 | Shafiee et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hadi Shafiee (Boston, Massachusetts); Prudhvi Thirumalaraju (Watertown, Massachusetts); Manoj Kumar Kanakasabapathy (Boston, Massachusetts); Sai Hemanth Kumar (Watertown, Massachusetts) |
| ABSTRACT | Systems and methods are provided for medical image classification of images from varying sources. A set of microscopic medical images are acquired, and a first neural network module configured to reduce each of the set of microscopic medical images to a feature representation is generated. The first neural network module, a second neural network module, and a third neural network module are trained on at least a subset of the set of microscopic medical images. The second neural network module is trained to receive feature representation associated with an image of the microscopic images and classify the image into one of a first plurality of output classes. The third neural network module is trained to receive the feature representation, classify the image into one of a second plurality of output classes based on the feature representation, and provide feedback to the first neural network module. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 18/011225 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0016 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20021 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/762 (20220101) G06V 10/774 (20220101) G06V 20/698 (20220101) G06V 2201/03 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237759 | BUCKLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); Mark A. BUCKLER (Wenham, Massachusetts); Vladimir VALTCHINOV (Waban, Massachusetts); David S. PAIK (Moon Bay, California) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, February 08, 2023 |
| APPL NO | 18/166284 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) Original (OR) Class G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238030 | KEANE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. KEANE (Miami, Florida); W. Dalton DIETRICH (Miami, Florida); Nadine KERR (Miami, Florida); Shu WU (Miami, Florida); Juan Pablo DE RIVERO VACCARI (Miami, Florida) |
| ABSTRACT | The present invention provides compositions and methods for reducing inflammation in the lungs of a mammal that is afflicted by a condition that leads to inflammation in the lungs. The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s). |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/934915 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) A61K 39/3955 (20130101) A61K 39/39541 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 25/00 (20180101) A61P 25/14 (20180101) A61P 25/28 (20180101) A61P 29/00 (20180101) A61P 37/06 (20180101) Guiding Railway Traffic; Ensuring the Safety of Railway Traffic B61L 23/041 (20130101) B61L 27/53 (20220101) B61L 29/30 (20130101) Peptides C07K 16/18 (20130101) C07K 16/24 (20130101) Information Storage Based on Relative Movement Between Record Carrier and Transducer G11B 19/08 (20130101) Original (OR) Class G11B 19/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238099 | BEESON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Simphotek, Inc. (Newark, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl BEESON (Princeton, New Jersey); Evgueni PARILOV (Brooklyn, New York); Mary POTASEK (Princeton, New Jersey) |
| ABSTRACT | A method of administering interstitial photodynamic therapy to a target region of a patient may include receiving information associated with the target region, an initial photosensitizer concentration, a plurality of initial photosensitizer photokinetic rate parameters, and a threshold treatment dose for a photosensitizer, the threshold treatment dose being a threshold photodynamic therapy-dose or a threshold reactive oxygen species dose. A location in the target region for inserting at least one interstitial treatment fiber to deliver the treatment light, and initial values for treatment light transmission is determined. Computational spatial elements are determined for the target region and for the location of emitting surfaces of the at least one interstitial treatment fiber, and a light fluence rate for delivering treatment light to each of the computational spatial elements. A treatment dose is determined based on the light fluence rate, the plurality of photosensitizer photokinetic rate parameters, and a photokinetic rate equation. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 18/041079 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 5/067 (20210801) A61N 5/0601 (20130101) A61N 2005/063 (20130101) A61N 2005/0626 (20130101) A61N 2005/0651 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238135 | Jaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Farouc Amin Jaffer (Boston, Massachusetts); Guillermo Tearney (Boston, Massachusetts); Joseph Gardecki (Boston, Massachusetts); Mazen Albaghdadi (Boston, Massachusetts); Ryutaro Ikegami (Boston, Massachusetts); Mohamad Kassab (Boston, Massachusetts) |
| ABSTRACT | A computer-implemented method for diagnosing a medical condition of a patient is provided. The method can include causing, using one or more processors, an excitation source to emit an excitation light towards a region of interest of an artery, receiving, using the one or more processors and a detector, imaging data of the region of interest of the artery, generating, using the one or more processors and the imaging data, an image of the region of interest, determining, using the one or more processors, a risk region of an atheromatous plaque, based on the imaging data, and determining, using the one or more processors, that the patient has a severe case of an atheromatous plaque, based on the determined risk region of the atheromatous plaque. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 18/001923 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0082 (20130101) Image Data Processing or Generation, in General G06T 2207/30101 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238153 | LEVITT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Joseph LEVITT (Seattle, Washington); Matthew Colin THOMPSON (Mukilteo, Washington) |
| ABSTRACT | Methods and systems are provided for Z-pinch plasma and other plasma confinement utilizing various electrode compositions and configurations. In one example, a plasma confinement system includes a plurality of electrodes, each electrode of the plurality of electrodes arranged coaxially with respect to an assembly region of the plasma confinement system and positioned so as to be exposed to the assembly region, wherein one or more electrodes of the plurality of electrodes includes an electrode material which releases hydrogen gas above a threshold temperature. In an additional or alternative example, a plasma confinement system includes an electrode body including a nosecone, and a liquid metal, a portion of the liquid metal forming a protective film between a surface of the nosecone and an exterior of the nosecone during operation of the plasma confinement system. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/101081 |
| CURRENT CPC | Fusion Reactors G21B 1/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238154 | THOMPSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Colin THOMPSON (Mukilteo, Washington); Benjamin Joseph LEVITT (Seattle, Washington) |
| ABSTRACT | Methods and systems are provided for Z-pinch plasma and other plasma confinement utilizing various electrode compositions and configurations. In one example, a plasma confinement system includes a plurality of electrodes, each electrode of the plurality of electrodes arranged coaxially with respect to an assembly region of the plasma confinement system and positioned so as to be exposed to the assembly region, wherein one or more electrodes of the plurality of electrodes includes an electrode material which releases hydrogen gas above a threshold temperature. In an additional or alternative example, a plasma confinement system includes an electrode body including a nosecone, and a liquid metal, a portion of the liquid metal forming a protective film between a surface of the nosecone and an exterior of the nosecone during operation of the plasma confinement system. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/101086 |
| CURRENT CPC | Fusion Reactors G21B 1/03 (20130101) G21B 1/15 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238231 | Laskin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julia Laskin (West Lafayette, Indiana); Xiangtang Li (West Lafayette, Indiana) |
| ABSTRACT | The microfluidic probe is configured for nano spray desorption electro spray ionization (nano-DESI) with fixed positioning of the channels therein for consistent and stable formation of a liquid bridge for nano-DESI and mass spectrometry imaging (MSI). The microfluidic probe may incorporate a shear force probe for sensing and maintaining a desired distance between the probe and the sample surface being analyzed. The microfluidic probe includes a primary solvent channel and a spray channel intersecting at a fixed orientation relative to each other at an opening in a tip of the probe. The microfluidic probe is constructed from a plastic material. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/976967 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0004 (20130101) H01J 49/0445 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230232831 | KLIMAVICZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Scott KLIMAVICZ (Ames, Iowa); Joel Robert COATS (Ames, Iowa) |
| ABSTRACT | The present application relates to monoterpenoid and phenylpropanoid carbonate esters and methods of their making and use as repellents. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 18/015746 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 47/06 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 17/00 (20210801) Acyclic or Carbocyclic Compounds C07C 69/96 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233085 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Yongyi Zhao (Houston, Texas); Ankit Raghuram (Houston, Texas); Ashok Veeraraghavan (Houston, Texas); Jacob Robinson (Houston, Texas) |
| ABSTRACT | A system for imaging a target embedded in a scattering media includes: one or more light sources that are pulsed lights at one or more wavelengths in a range of visible to near-infrared; a detector, including a photodetector array with a time-gating function, configured to collect a scattered light after a gate start time; and a processor configured to determine an image of the target based on the scattered light. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160509 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0068 (20130101) A61B 5/0073 (20130101) Original (OR) Class A61B 2560/029 (20130101) A61B 2562/046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233143 | CHON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KI CHON (Mansfield, Connecticut); YOUNGSUN KONG (Storrs, Connecticut); HUGO POSADA-QUINTERO (Stafford Springs, Connecticut) |
| ABSTRACT | Methods, systems, and apparatuses for determining an indication of pain of a user are disclosed. Electrodermal activity (EDA) data from a sensor may be received. The EDA data may be indicative of one or more physiological signals derived from sweat gland activity of the user. Index values may be determined based on the EDA data. The index values may be compared to a threshold to determine if one or more of the values of the index value satisfies the threshold. Satisfying the threshold may indicate a pain in the user, a pain level for the user and/or a source of pain within the user. The indication may be caused to be output so that the user or others may be informed of an objective measurement of the pain in the user. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868383 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0531 (20130101) A61B 5/4824 (20130101) Original (OR) Class A61B 5/7278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233174 | Murthi |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah B. Murthi (Lutherville, Maryland) |
| ABSTRACT | Disclosed are systems and methods using ultrasound to predict if a patient's cardiac stroke volume will increase with a fluid bolus. Ultrasound measures are taken before administering a fluid bolus, including measurement of the left ventricular outflow tract velocity time integral (LVOT VTI), and venous measurements of the internal jugular vein. Data collected from such ultrasound scan is then used to predict the patient's cardiac volume response in the event that a fluid bolus is administered to that patient. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/064972 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/065 (20130101) Original (OR) Class A61B 8/461 (20130101) A61B 8/488 (20130101) A61B 8/5223 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2205/3375 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233340 | PELZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua PELZ (San Diego, California); Luca DE VIVO (San Diego, California); Falko KUESTER (La Jolla, California); Herbert BARRACK (La Mesa, California) |
| ABSTRACT | A unibody transtibial prosthetic device includes a socket personalized for a specific patient's residual limb. A pylon extends from the socket, the pylon being a unitary polymer structure of interconnected elongated supports having open spaces therebetween. The device also includes a foot-ankle complex, the foot-ankle complex being a unitary polymer extending from the pylon, the foot and ankle unitary structure being shaped to provide multi-axial dynamic flex to enable dorsiflexion, plantar flexion, inversion and eversion motion for smooth symmetric gait performance and energy capture and return. The socket, pylon and foot-ankle complex are portions of a unibody. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 18/009915 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) Original (OR) Class A61F 2/80 (20130101) A61F 2/5046 (20130101) A61F 2002/607 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233343 | Pelz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Pelz (San Diego, California); Luca De Vivo (San Diego, California); Falko Kuester (La Jolla, California); Herbert J. Barrack (La Mesa, California) |
| ABSTRACT | A unibody transtibial prosthetic device includes a socket personalized for a specific patient’s residual limb. A pylon extends from the socket, the pylon being a unitary polymer structure of interconnected elongated supports having open spaces therebetween. The device also includes a foot-ankle complex, the foot-ankle complex being a unitary polymer extending from the pylon, the foot and ankle unitary structure being shaped to provide multi-axial dynamic flex to enable dorsiflexion, plantar flexion, inversion and eversion motion for smooth symmetric gait performance and energy capture and return. The socket, pylon and foot-ankle complex are portions of a unibody. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/185011 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/80 (20130101) Original (OR) Class A61F 2/5046 (20130101) A61F 2/6607 (20130101) A61F 2002/505 (20130101) A61F 2002/607 (20130101) A61F 2002/6621 (20130101) A61F 2002/6642 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233512 | PATEL |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | REKHA PATEL (IRMO, South Carolina) |
| ABSTRACT | Methods for modification of abnormal protein interactions manifested as excessive PACT-mediated PKR activation within cells are described. Methods include administration of luteolin to cells that exhibit dysregulation in PACT-mediated PKR activation. Methods can decrease or prevent excessive non-viral PACT-mediated PKR activation in a cell as may occur due to expression by the cell of a mutant PACT protein. Methods can decrease an abnormal prolonged stress response as may occur in the absence of a stress-inducing activity or agent. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883227 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233564 | Schiff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Institut D'Investigacions Biomediques August Pi Isunyer (IDIBAPS) (Barcelona, Spain); Baylor College of Medicine (Houston, Texas); Memorial Sloan Kettering Cancer Center (New York, New York); Universitat de Barcelona (Barcelona, Spain) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachel Schiff (Bellaire, Texas); Mothaffar Rimawi (Houston, Texas); Jamunarani Veeraraghavan (Houston, Texas); C. Kent Osborne (Houston, Texas); Carolina Gutierrez (Houston, Texas); Aleix Prat (Barcelona, Spain); Jorge Reis-Filho (New York, New York) |
| ABSTRACT | Embodiments of the disclosure include methods and compositions related to treating an individual for HER2+ positive cancer with an appropriate treatment based on outcome of a multiparameter classifier. The methods allow for identification of HER2+ individuals that are suitable to avoid chemotherapy, in specific embodiments. Methods of the disclosure also allow for identification of HER2+ individuals that should not avoid chemotherapy. In specific embodiments, the multiparameter classifier identifies whether there is (1) a ratio of HER2 amplification, relative to a control probe, of greater than or equal to 4.5; (2) a HER2 expression level score of 3+, as determined by immunohistochemistry, in at least 90% of breast cancer cells; (3) whether there is a HER2-enriched molecular subtype; and (4) whether the individual has a wildtype PIKC3A gene. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/998240 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/4706 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/32 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233669 | ANDINO-PAVLOVSKY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Aleph Therapeutics, Inc. (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raul ANDINO-PAVLOVSKY (San Francisco, California); Yinghong XIAO (San Francisco, California); Gilad DOITSH (San Francisco, California); Robert NAKAMURA (Stanford, California); Dale TALBOT (Stanford, California) |
| ABSTRACT | The present disclosure generally relates to, inter alia, to nucleic acid constructs encoding a modified enterovirus genome that is devoid of partial or complete nucleic acid sequences encoding viral structural proteins. The disclosure also provides compositions and methods useful for producing defective interfering particles (DIPs) of enteroviruses, and for the prevention and/or treatment of various health conditions such as immune diseases and viral infections. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 18/003799 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/125 (20130101) A61K 39/145 (20130101) A61K 39/155 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) C12N 2770/32621 (20130101) C12N 2770/32634 (20130101) C12N 2770/32652 (20130101) C12N 2770/32671 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233689 | Spiegel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); David Caianiello (New Haven, Connecticut); Mengwen Zhang (New Haven, Connecticut) |
| ABSTRACT | The present disclosure is directed to bifunctional small molecules which contain a circulating protein binding moiety (CPBM) linked through a linker group to a cellular receptor binding moiety (CRBM) which is a membrane receptor of degrading cell such as a hepatocyte or other degrading cell. In certain embodiments, the (CRBM) is a moiety which binds to asialoglycoprotein receptor (an asialoglycoprotein receptor binding moiety, or ASGPRBM) of a hepatocyte. In additional embodiments, the (CRBM) is a moiety which binds to a receptor of other cells which can degrade proteins, such as a LRP1, LDLR, FcγRI, FcRN, Transferrin or Macrophage Scavenger receptor. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/161712 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/54 (20170801) A61K 47/55 (20170801) A61K 47/64 (20170801) A61K 47/545 (20170801) Original (OR) Class A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233691 | XIAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas); Tract Pharmaceuticals, Inc. (West Hartford, Connecticut) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); Tract Pharmaceuticals, Inc. (West Hartford, Connecticut) |
| INVENTOR(S) | Wa XIAN (Sugar Land, Texas); Frank MCKEON (Sugar Land, Texas); Shan WANG (Houston, Texas); Audrey-Ann LIEW (Houston, Texas); Matthew VINCENT (Amesbury, Massachusetts) |
| ABSTRACT | The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of esophageal tissue and gastric tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic Barrett's Esophagus stem cells (BESCs) or Gastric Intestinal Metaplasia stem cells (GIMSCs) relative to normal regenerative esophageal stem cells or gastric stem cells in the tissue in which the BESCs or GIMSCs are found. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 18/048773 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0024 (20130101) A61K 9/51 (20130101) A61K 9/0053 (20130101) A61K 31/5025 (20130101) A61K 47/55 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234137 | Reutzel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Reutzel (University Park, Pennsylvania); Jan Petrich (University Park, Pennsylvania); Abdalla R. Nassar (University Park, Pennsylvania); Shashi Phoha (University Park, Pennsylvania); David J. Corbin (University Park, Pennsylvania); Jacob P. Morgan (University Park, Pennsylvania); Evan P. Diewald (University Park, Pennsylvania); Robert W. Smith (University Park, Pennsylvania); Zackary Keller Snow (University Park, Pennsylvania) |
| ABSTRACT | Embodiments relate to in-situ process monitoring of a part being made via additive manufacturing. The process can involve capturing computed tomography (CT) scans of a post-built part. A neural network (NN) can be used during the build of a new part to process multi-modal sensor data. Spatial and temporal registration techniques can be used to align the data to x,y,z coordinates on the build plate. During the build of the part, the multi-modal sensor data can be superimposed on the build plate. Machine learning can be used to train the NN to correlate the sensor data to a defect label or a non-defect label by looking to certain patterns in the sensor data at the x,y,z location to identify a defect in the CT scan at x,y,z. The NN can then be used to predict where defects are or will occur during an actual build of a part. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 18/002883 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/38 (20210101) B22F 10/85 (20210101) Original (OR) Class B22F 10/366 (20210101) B22F 12/90 (20210101) B22F 2999/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234279 | Kutchko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Cynthia Kutchko (Pittsburgh, Pennsylvania); Michael Anthony Bubas (Pittsburgh, Pennsylvania); Bryan William Wilkinson (Pittsburgh, Pennsylvania) |
| ABSTRACT | A computer system (110) for part production using additive design receives a computer-aided design (CAD) file that describes physical dimensions of a target object (120). The computer system (110) identifies a physical boundary portion (300) of the target object within the CAD file. The computer system determines a target flow rate to infill the physical boundary portion (300) with the infill material. Additionally, the computer system (110) generates a first tool path to flow infill material into the physical boundary portion (300). Further, the computer system (110) sends instructions to a computer system in communication with a dispenser (100) that cause the dispenser to implement the first tool path while flowing the infill material into the physical boundary portion (300). |
| FILED | Monday, May 03, 2021 |
| APPL NO | 18/003709 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/35 (20170801) B29C 64/118 (20170801) Original (OR) Class B29C 64/314 (20170801) B29C 64/336 (20170801) B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234680 | Sullivan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Peter Sullivan (Encinitas, California); W Wayne Husband, III (San Diego, California); Kelly Moorleghem (Poway, California); Frank Chang (La Mesa, California); Brian Granger (San Diego, California) |
| ABSTRACT | A towed array ballasting unit includes a canister, an internal bladder, an external bladder, a motor valve, fluid, a shroud, and printed circuit boards. The canister includes a head endcap and an aft endcap with the internal bladder located within and attached to an internal end of a fluid channel. An external bladder is located outside the canister and attached to an external end of the fluid channel. The motor valve is attached to the aft endcap of the canister and the internal end of fluid channel. The fluid moves between the internal bladder and external bladder via the fluid channel. The shroud forms a shell around the canister, external bladder, and a connector that connects the towed array ballasting system to an array tail. The printed circuit boards execute instructions provided by a computer. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582247 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 39/00 (20130101) Original (OR) Class B63B 79/15 (20200101) B63B 79/40 (20200101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 1/3826 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234856 | Maruyama |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benji Maruyama (Yellow Springs, Ohio) |
| ABSTRACT | Methods and apparatuses for making nanomaterials are disclosed. The methods involve passing one or more source materials through a high pressure and high temperature chamber with an open throat, and then allowing the reactants to expand into a lower pressure, lower temperature zone. The source material is non-stoichiometric and fuel-rich so that excess un-combusted primary source material can form the nanomaterials. In some cases, the apparatus may be in the form of a modified rocket engine. The methods may be used to make various materials including: carbon nanotubes, boron nitride nanomaterials, titanium dioxide, and any materials that are currently produced by flame synthesis, including but not limited to electrocatalysts. The methods may also be used to make nanomaterials outside the Earth's atmosphere. The methods can include making, coating, or repairing structures in space, such as antennae. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/094494 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/162 (20170801) C01B 35/146 (20130101) Original (OR) Class Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 23/047 (20130101) Antennas, i.e Radio Aerials H01Q 1/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234990 | So et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Department of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher R. So (Alexandria, Virginia); Kathryn J. Wahl (Alexandria, Virginia) |
| ABSTRACT | Peptides that form adhesive bonds, even in aqueous and/or saline environments, are disclosed. When aggregated, the peptides may be used in methods for producing hydrogels and/or adhesive materials. Synthetic peptide analogs are provided that are designed based on protein sequences found in barnacle adhesive, and may optionally be augmented with chemistry from other organisms that secrete proteins that adhere to substrates. The peptides may be used, for example, in biomedical and aqueous applications. Methods of using the aggregated peptides as adhesives are also provided. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172867 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 37/12 (20130101) Peptides C07K 14/001 (20130101) Original (OR) Class Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 5/04 (20130101) C09J 189/00 (20130101) C09J 2489/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235002 | ALVAREZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Theradaptive, Inc. (Frederick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis ALVAREZ (Lexington, Massachusetts); David STEWART (Monrovia, Maryland); Hyeon PARK (Clarksburg, Maryland); Todd HEIL (Mt. Airy, Maryland) |
| ABSTRACT | Provided herein are polypeptides comprising a therapeutic targeted for delivery to an organ or tissue, and uses thereof. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046810 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/00 (20180101) Peptides C07K 14/51 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235027 | Brody et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The USA, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Brody (Bethesda, Maryland); Thomas J. Esparza (Frederick, Maryland) |
| ABSTRACT | The invention generally relates to VHH domains that specifically bind a severe acute respiratory syndrome coronavirus spike protein receptor binding domain, corresponding expression vectors and host cells, and methods of treatment using such VHH domains. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 18/011767 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Preparations for Medical, Dental, or Toilet Purposes A61K 2039/54 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235036 | Akassoglou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katerina Akassoglou (San Francisco, California); Mark Petersen (North Vancouver AB, Canada) |
| ABSTRACT | Compositions and methods to treat or prevent neurodegeneration in a mammal comprising administering to the mammal in need thereof an effective amount of an inhibitor of ACVR1 (Alk2). |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/008324 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235296 | Levin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Levin (Beverly, Massachusetts); Sam Kriegman (Burlington, Vermont); Douglas Blackiston (Medford, Massachusetts); Josh Bongard (Burlington, Vermont) |
| ABSTRACT | Disclosed are engineered multicellular organisms. Also disclosed are systems and methods for designing, preparing, and utilizing the engineered multicellular organisms. |
| FILED | Tuesday, January 12, 2021 |
| APPL NO | 18/003705 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/545 (20130101) Reclamation of Contaminated Soil B09C 1/10 (20130101) B09C 2101/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) Original (OR) Class C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235756 | DROTMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dylan DROTMAN (San Diego, California); Saurabh JADHAV (San Diego, California); Michael T. TOLLEY (La Jolla, California); David SHARP (San Diego, California); Christian CHAN (Brighton, Massachusetts) |
| ABSTRACT | A pneumatic circuit for controlling the activation of a robot with inflatable chambers includes at least one ring oscillator formed from a plurality of valves connected in series to selectively admit fluid pressure to inflate and deflate the chambers. Sequential actuation of the valves induces sequential bending and rotation of combinations of the chambers to effect motion. A switching valve changes the actuation sequence of the oscillator valves to change the direction of motion. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099828 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/142 (20130101) Motor Vehicles; Trailers B62D 57/032 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 13/02 (20130101) Original (OR) Class F15B 2211/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235998 | Mathis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Southwest Research Institute (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James T Mathis (Fair Oaks Ranch, Texas); Matthew V. Grimm (San Antonio, Texas); Nicholas J. Mueschke (San Antonio, Texas); Edward V. O'Hare (San Antonio, Texas) |
| ABSTRACT | An arena test system for characterizing fragments from a warhead. An entry panel and an exit panel are arranged in a wedge configuration with a wedge-shaped air space between them. Fragments are imaged as they pass through this wedge. A soft catch box is located behind the exit panel such that fragments that pass through the exit panel enter the soft catch box and are decelerated within the soft catch box. |
| FILED | Sunday, January 23, 2022 |
| APPL NO | 17/581951 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/20 (20130101) F42B 35/00 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/207 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236215 | Strong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Reg. of the Univ. of Colorado, a body corp. (Denver, Colorado); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth F. Strong (Boulder, Colorado); Gregory B. Rieker (Boulder, Colorado); Juliet T. Gopinath (Boulder, Colorado); Alexander Anderson (Boulder, Colorado); Michael P. Brenner (Cambrdige, Massachusetts) |
| ABSTRACT | A structured-light-velocimetry method includes extracting one or more bursts from a time-varying signal generated by detecting scattered light from a tracer particle passing through a structured optical beam; fitting each of the one or more bursts to a multi-variable model to extract a plurality of fitted parameters; and executing a machine-learning model with the plurality of fitted parameters to predict an angular velocity of the tracer particle. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/998262 |
| CURRENT CPC | Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 1/06 (20130101) G01P 3/36 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236305 | Foreman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Terry Lee Foreman (Colonial Beach, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Terry Lee Foreman (Colonial Beach, Virginia) |
| ABSTRACT | A computer-implemented method is provided for identifying a target amid clutter and minimize cross-talk from receive signals returned therefrom via a Multiple Input Multiple Output (MIMO) radar system that emits transmit signals into a resolution cell that contains the target and the clutter. The method includes employing a match filter to estimate a set of parameters from each receive signal of the receive signals; determining interference correlation; estimating clutter correlation; forming an optimum detector with the estimated correlation for each receive signal among the receive signals; employing the optimum detector to estimate the target set of parameters from each receive signal as an estimated target parameter; returning to the forming operation in response to the estimated target parameter exceeding an established tolerance; and applying the estimated target parameter to the receive signals for submission to the MIMO radar system. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/082652 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/0235 (20210501) G01S 13/5244 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236433 | Drexler |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Robert Drexler (San Diego, California) |
| ABSTRACT | An atmospheric distortion compensator comprising a disc and a rotator. The disc, which comprises a phase-modifying structure, is rotationally balanced about a center point. The rotator is mechanically coupled to the disc's center point and configured to spin the disc about an axis. When spinning, the disc is configured to control a property of a beam, which is propagating in parallel to the axis and impinging on the disc. By so doing, scintillation effects within an electro-optical field caused by propagation of the beam within a heterogeneous medium are reduced. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/583421 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/0037 (20130101) G02B 27/4205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236471 | Hosseini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Analog Photonics LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | Analog Photonics LLC (Boston, Massachusetts) |
| INVENTOR(S) | Ehsan Hosseini (Boston, Massachusetts); Michael Watts (Hingham, Massachusetts) |
| ABSTRACT | Aspects of the present disclosure describe optical phased array structures and devices in which hyperbolic phase envelopes are employed to create focusing and diverging emissions in one and two dimensions. Tuning the phase fronts moves focal point spot in depth and across the array. Grating emitters are also used to emit light upward (out of plane). Adjusting the period of the gratings along the light propagation direction results in focusing the light emitted from the gratings. Changes in the operating wavelengths employed moves the focal spot along the emitters. |
| FILED | Wednesday, March 08, 2023 |
| APPL NO | 18/180241 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/292 (20130101) Original (OR) Class G02F 2201/305 (20130101) G02F 2203/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237313 | Ren et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NVIDIA Corp. (Santa Clara, California) |
| ASSIGNEE(S) | NVIDIA Corp. (Santa Clara, California) |
| INVENTOR(S) | Haoxing Ren (Austin, Texas); George Ferenc Kokai (Roseville, California); Ting Ku (San Jose, California); Walker Joseph Turner (Jacksonville, Florida) |
| ABSTRACT | A graph neural network to predict net parasitics and device parameters by transforming circuit schematics into heterogeneous graphs and performing predictions on the graphs. The system may achieve an improved prediction rate and reduce simulation errors. |
| FILED | Monday, April 03, 2023 |
| APPL NO | 18/295145 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/9024 (20190101) G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 3/045 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237363 | Oh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changhun Oh (Chicago, Illinois); Youngrong Lim (Seoul, South Korea); Yat Wong (Chicago, Illinois); William Fefferman (Chicago, Illinois); Liang Jiang (Chicago, Illinois) |
| ABSTRACT | This disclosure relates to a method and system for efficiently and analytically generating spectra associated with transitions between thermal states in a multi-mode bosonic system using a classical algorithm to compute Fourier components of the transition spectra of the multi-mode bosonic system based on a representation space sampling method inspired by quantum Gaussian boson sampling followed by an inverse Fourier transform. The disclosed method and system particularly apply to efficient estimation of molecular vibronic spectra. For example, an exact solution of the Fourier components of molecular vibronic spectra at zero temperature may be analytically computed in a representation space by using, for example, a positive P-representation of the multi-mode bosonic vibronic quantum states of the molecule. Such a method may be further applied to more general vibronic spectroscopy, such as computing molecular vibronic spectra at finite temperatures by introducing additional auxiliary bosonic modes and computing vibronic spectra associated with non-thermal states, such as Fock states. |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/156254 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/60 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237384 | Dowdell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles W. Dowdell (Lynn, Massachusetts); David Anthony Mercer (Cincinnati, Ohio) |
| ABSTRACT | Methods, apparatus, systems, and articles of manufacture to implement a random forest are disclosed. An example apparatus includes logic circuitry to, for a first cycle, identify a feature value corresponding to an initial node identifier of a data structure, the feature value including in an input feature array. The apparatus further includes a comparator to compare the feature value to a threshold corresponding to the initial node identifier. The apparatus further includes a register to store an updated node identifier, the updated node identifier being (a) a first updated node identifier when the feature value exceeds the threshold or (b) a second updated node identifier when the feature value is below the threshold, the logic circuitry to use the updated node identifier for a second cycle. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575415 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/20 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237790 | Valentine et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Valentine (Nashville, Tennessee); Yuankai Huo (Nashville, Tennessee); Hanyu Zheng (Nashville, Tennessee); Quan Liu (Nashville, Tennessee) |
| ABSTRACT | A system for identifying objects in images is provided. The system may include an optical front end and a digital back end. The optical front end includes a metalens that duplicates a received image into multiple images, and a metasurface that receives the duplicate images and outputs a feature map based on the received images. The feature map may be equivalent to the computationally expensive convolution operations previously performed by a neural network. The feature map is provided to the digital back end, which uses a neural network to classify the object. Because the feature map included the convolution operations, the digital back end can classify the object more quickly and using fewer computing resources than previous systems. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/159832 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) Original (OR) Class G06V 10/764 (20220101) G06V 10/774 (20220101) G06V 10/7715 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237933 | Barton |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jonathan Scott Barton (Santa Barbara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Scott Barton (Santa Barbara, California) |
| ABSTRACT | A surgical trainer facilitates the training of a medical practitioner in one or more surgical includes one or more layers of healable synthetic tissues. The healable synthetic tissue includes healable material configured to facilitate a re-bonding of the healable synthetic tissues to their original shape after an incision is made to the healable synthetic tissues. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/101366 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238465 | Colbert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Adam E. Colbert (Alexandria, Virginia); Diogenes Placencia (Alexandria, Virginia); Janice E. Boercker (Fairfax, Virginia); Edward H. Aifer (Arlington, Virginia); Joseph G. Tischler (Alexandria, Virginia); Erin L. Ratcliff (Tucson, Arizona) |
| ABSTRACT | Photodiodes configured to convert incident photons in the short-wave infrared (SWIR) to electric current, where the photodiodes have a PbS/PbClx core/shell nanocrystal absorber layer. The PbClx shell in the PbS/PbClx nanocrystals provide native passivation in the (100) crystal facets and enable removal of pre-device processing ligands and ligand exchange on the (111) crystal facets of the PbS/PbClx nanocrystals such that the photodiode exhibits reduced current densities under reverse bias and greater infrared photoresponse, providing improved device performance as compared to photodiodes having absorber layers formed from PbS core nanocrystals alone. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/060676 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2031 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0324 (20130101) Original (OR) Class Organic electric solid-state devices H10K 30/35 (20230201) H10K 85/30 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238476 | IYER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Subramanian S. IYER (Los Angeles, California); Goutham EZHILARASU (Los Angeles, California) |
| ABSTRACT | Example implementations include a method of mass transfer of display elements, by depositing one or more resist layers between one or more display elements disposed on a photoemitting layer, depositing at least one stress buffer layer between the resist layers, removing the resist layer and at least a portion of the photoemitting layer disposed in contact with the resist layers to form resist layer gaps on a wafer substrate, dicing the wafer substrate at the resist layer gaps to form at least one wafer die, separating the wafer substrate from the display elements by irradiation at corresponding first surfaces of the display elements, removing the stress buffer layers from the wafer die, and bonding the portion of the display elements to a first handler substrate at one or more electrode pads of the portion of the display elements. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 18/007697 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 24/24 (20130101) H01L 24/82 (20130101) H01L 24/95 (20130101) H01L 25/167 (20130101) H01L 33/32 (20130101) H01L 33/56 (20130101) H01L 33/0093 (20200501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238559 | Shepherd et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert F. Shepherd (Ithaca, New York); Hyeon Seon An (Ithaca, Indiana); Xu Liu (Ithaca, New York); Matthew Ryan Daniel (Ithaca, New York) |
| ABSTRACT | A data communication device includes a battery having a first flowable electrolyte. In some embodiments, the battery is a redox flow battery (RFB) or a hybrid RFB. A first channel contains the first flowable electrolyte of the battery (i.e., contains at least a portion of the first flowable electrolyte). The first channel may include a tube and/or a reservoir. At least a portion of the first channel may be flexible and/or stretchable. The first channel has a first electrode configured to impart and/or receive a first electrical signal in the first flowable electrolyte. The first electrical signal may be a digital signal. The first electrical signal may be an encoded signal. The device may include a transceiver in electronic communication with the first electrode. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 18/010709 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) Original (OR) Class H01M 8/04186 (20130101) H01M 8/04276 (20130101) H01M 8/04537 (20130101) H01M 2250/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238858 | White et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kaney Aerospace, Inc. (Rockford, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam White (Beavercreek, Ohio); Erik Michael Plugge (Rockford, Illinois); Donald Fredrick Knight (Davis, Illinois) |
| ABSTRACT | The present disclosure relates to electromagnetically-controlled magnetic cycloidal gear assemblies configured to achieve enhanced torque capacity, and methods of operating same. In one example embodiment, a method includes sensing a position of a cycloid relative to a stator, where the stator includes a plurality of electromagnets, and the cycloid includes a plurality of permanent magnets. Also, the method includes determining respective torque characteristics concerning the respective electromagnets based upon the sensed position, where the respective torque characteristic that is determined concerning each respective one of the electromagnets is indicative of a respective relative position of the respective electromagnet in relation to a respective closest one of the permanent magnets. The method additionally includes outputting from a controller, for receipt respectively at least indirectly by the respective electromagnets or respective control devices coupled thereto, a plurality of output signals respectively based at least in part upon the respective torque characteristics. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581450 |
| CURRENT CPC | Dynamo-electric Machines H02K 7/003 (20130101) H02K 7/116 (20130101) Original (OR) Class H02K 11/30 (20160101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230233085 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Yongyi Zhao (Houston, Texas); Ankit Raghuram (Houston, Texas); Ashok Veeraraghavan (Houston, Texas); Jacob Robinson (Houston, Texas) |
| ABSTRACT | A system for imaging a target embedded in a scattering media includes: one or more light sources that are pulsed lights at one or more wavelengths in a range of visible to near-infrared; a detector, including a photodetector array with a time-gating function, configured to collect a scattered light after a gate start time; and a processor configured to determine an image of the target based on the scattered light. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160509 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0068 (20130101) A61B 5/0073 (20130101) Original (OR) Class A61B 2560/029 (20130101) A61B 2562/046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233274 | BEN-TZVI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pinhas BEN-TZVI (Blacksburg, Virginia); Yujiong LIU (Blacksburg, Virginia) |
| ABSTRACT | Various embodiments for a continuum manipulator are described for use in robotic surgical systems or other desired applications. The continuum manipulator includes an extensible continuum manipulator (ECM) body comprising a plurality of subsegments serially connected to one another. Adjacent ones of the subsegments are coupled by rack-and-pinion transmission sets that are configured to propagate subsegment motion to downstream ones of the subsegments. A multi-chain flexible parallel mechanism is provided in each of the subsegments that is configured to generate a desired spatial bending and extension mobility for each of the subsegments. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/996712 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/30 (20160201) Original (OR) Class A61B 2034/301 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 9/065 (20130101) B25J 9/104 (20130101) B25J 9/1035 (20130101) B25J 18/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233340 | PELZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua PELZ (San Diego, California); Luca DE VIVO (San Diego, California); Falko KUESTER (La Jolla, California); Herbert BARRACK (La Mesa, California) |
| ABSTRACT | A unibody transtibial prosthetic device includes a socket personalized for a specific patient's residual limb. A pylon extends from the socket, the pylon being a unitary polymer structure of interconnected elongated supports having open spaces therebetween. The device also includes a foot-ankle complex, the foot-ankle complex being a unitary polymer extending from the pylon, the foot and ankle unitary structure being shaped to provide multi-axial dynamic flex to enable dorsiflexion, plantar flexion, inversion and eversion motion for smooth symmetric gait performance and energy capture and return. The socket, pylon and foot-ankle complex are portions of a unibody. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 18/009915 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) Original (OR) Class A61F 2/80 (20130101) A61F 2/5046 (20130101) A61F 2002/607 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233343 | Pelz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Pelz (San Diego, California); Luca De Vivo (San Diego, California); Falko Kuester (La Jolla, California); Herbert J. Barrack (La Mesa, California) |
| ABSTRACT | A unibody transtibial prosthetic device includes a socket personalized for a specific patient’s residual limb. A pylon extends from the socket, the pylon being a unitary polymer structure of interconnected elongated supports having open spaces therebetween. The device also includes a foot-ankle complex, the foot-ankle complex being a unitary polymer extending from the pylon, the foot and ankle unitary structure being shaped to provide multi-axial dynamic flex to enable dorsiflexion, plantar flexion, inversion and eversion motion for smooth symmetric gait performance and energy capture and return. The socket, pylon and foot-ankle complex are portions of a unibody. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/185011 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/80 (20130101) Original (OR) Class A61F 2/5046 (20130101) A61F 2/6607 (20130101) A61F 2002/505 (20130101) A61F 2002/607 (20130101) A61F 2002/6621 (20130101) A61F 2002/6642 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233479 | GIRIDHAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun V. GIRIDHAR (West Lafayette, Indiana); Michael HARRIS (West Lafayette, Indiana); Gintaras V. REKLAITIS (West Lafaytte, Indiana); Lynne S. TAYLOR (West Lafaytte, Indiana); Zoltan K. NAGY (West Lafayette, Indiana); Elcin ICTEN (West Lafayette, Indiana); Frederick FIESSER (Philadelphia, Pennsylvania); Laura HIRSHFIELD (Ann Arbor, Michigan) |
| ABSTRACT | Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluiddispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152394 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/7007 (20130101) Original (OR) Class A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 31/196 (20130101) A61K 31/415 (20130101) A61K 31/635 (20130101) A61K 47/10 (20130101) A61K 47/14 (20130101) A61K 47/34 (20130101) A61K 47/38 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 4/002 (20130101) B01J 4/02 (20130101) B01J 4/008 (20130101) B01J 2204/005 (20130101) B01J 2204/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233607 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingxiao WANG (San Diego, California); Ziliang HUANG (San Diego, California); Yiqian WU (San Diego, California) |
| ABSTRACT | In alternative embodiments, provided are compositions, including recombinant expression systems and vectors, products of manufacture and kits, and methods, for remotely-controlled and non-invasive manipulation of intracellular nucleic acid expression, genetic processes, function and activity in live cells such as T cells in vivo, for example, activating, adding functions or changing or adding specificities for immune cells, for monitoring physiologic processes, for the correction of pathological processes and for the control of therapeutic outcomes. In alternative embodiments, provided are blue-light-mediated light-inducible nuclear translocation and dimerization (LINTAD) systems for gene regulation to control cell activation based on the integration of light-sensitive LOV2-based nuclear localization, light-induced active transportation via the biLINuS motif, and CRY2-CIB1 dimerization that feature high spatiotemporal control to control or alter cell activities in vivo, for example, to limit CAR T cell activity to the tumor site for immunotherapy applications. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/800500 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/465 (20130101) A61K 2039/5156 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 2005/0663 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/00 (20130101) C07K 14/245 (20130101) C07K 14/4702 (20130101) C07K 14/4728 (20130101) C07K 14/7051 (20130101) C07K 14/7056 (20130101) C07K 14/70503 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/625 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2740/15043 (20130101) C12N 2800/80 (20130101) C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234000 | Schiffman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts); The Board of Trustees of the University of Maine System (Orono, Maine) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessica Deborah Schiffman (Amherst, Massachusetts); Caitlin Lake Howell (Veazie, Maine); Rushabh Manish Shah (Sunderland, Massachusetts) |
| ABSTRACT | A liquid infused membrane includes a porous fluorine-containing polymer membrane and a perfluoropolyether oil coating on at least a portion of the first surface and at least a portion of the pore wall. Advantageously, the liquid infused membrane does not exhibit gating. Methods for the manufacture thereof and uses of the liquid infused membrane are also disclosed. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100138 |
| CURRENT CPC | Separation B01D 61/145 (20130101) B01D 65/08 (20130101) B01D 67/0088 (20130101) Original (OR) Class B01D 69/02 (20130101) B01D 71/34 (20130101) B01D 71/52 (20130101) B01D 2325/02834 (20220801) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/444 (20130101) C02F 2303/20 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/42 (20130101) C08J 2327/16 (20130101) C08J 2471/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234125 | Hosek |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Persimmon Technologies Corporation (Wakefield, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Hosek (Salem, New Hampshire) |
| ABSTRACT | A system for forming a bulk material having insulated boundaries from a metal material and a source of an insulating material is provided. The system includes a heating device, a deposition device, a coating device, and a support configured to support the bulk material. The heating device heats the metal material to form particles having a softened or molten state and the coating device coats the metal material with the insulating material from the source and the deposition device deposits particles of the metal material in the softened or molten state on the support to form the bulk material having insulated boundaries. |
| FILED | Friday, March 17, 2023 |
| APPL NO | 18/122808 |
| CURRENT CPC | Apparatus for Applying Fluent Materials to Surfaces, in General B05C 5/001 (20130101) B05C 5/002 (20130101) Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 23/003 (20130101) Original (OR) Class Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/115 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/18 (20130101) C23C 6/00 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/24 (20130101) H01F 3/08 (20130101) H01F 41/0246 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24413 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234292 | Rojas et al. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Embry-Riddle Aeronautical University, Inc. (Daytona Beach, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eduardo Antonio Rojas et al. (Port Orange, Florida); Noemi Miguélea-Gòmez (Cambridge, Massachusetts) |
| ABSTRACT | Antenna structures can include an additively manufactured engineered fingerprint (AMEF). AMEF antenna features facilitate individual or type classification of an unknown source antenna. As described herein, physical features can be included in an additively manufactured antenna to facilitate source identification, such as without sacrificing antenna performance. In general, AMEF techniques can improve physical layer security, such as without dramatically increasing production cost or decreasing production throughput, as compared to other approaches. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/158007 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/386 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/00 (20141201) B33Y 80/00 (20141201) Antennas, i.e Radio Aerials H01Q 9/0407 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234989 | LISZKA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California); BASF SE (Ludwigshafen, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael LISZKA (San Diego, None); Alina BATZILLA (San Diego, None); Zachary WU (Pasadena, None); Frances ARNOLD (Pasadena, None) |
| ABSTRACT | The disclosure provides for artificial signal peptides generated by systems and methods utilizing deep learning. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/008033 |
| CURRENT CPC | Peptides C07K 14/00 (20130101) Original (OR) Class C07K 2319/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/248 (20130101) C12N 9/2411 (20130101) Enzymes C12Y 302/01001 (20130101) C12Y 302/01008 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235186 | Adamson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | University of Connecticut (Farmington, Connecticut) |
| INVENTOR(S) | Douglas H. Adamson (Mansfield Center, Connecticut); Feiyang Chen (Vernon, Connecticut); Elizabeth Brown (Mansfield Center, Connecticut) |
| ABSTRACT | The present disclosure provides advantageous sheet stabilized emulsion based inks, and improved methods for fabricating and using such inks. More particularly, the present disclosure provides improved methods for fabricating conductive inks derived from water-in-oil emulsions stabilized by sheets exfoliated from layered materials (e.g., substantially pristine and non-oxidized graphite or hexagonal boron nitride), and related methods of use. A layered material (e.g., substantially pristine and non-oxidized graphite or hexagonal boron nitride) can be exfoliated into individual sheets, and these sheets can be utilized to stabilize water-in-oil emulsions. In certain embodiments, by utilizing long chain alkanes (e.g., hexadecane), one can advantageously fabricate emulsions with high viscosity and stability. In this form, the emulsions can be used as inks, thereby advantageously providing an inexpensive route to printing electrically conducting and/or insulating lines and shapes. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/102389 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/38 (20130101) C08K 3/042 (20170501) C08K 2003/385 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/023 (20130101) Original (OR) Class C09D 11/38 (20130101) C09D 11/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235296 | Levin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Levin (Beverly, Massachusetts); Sam Kriegman (Burlington, Vermont); Douglas Blackiston (Medford, Massachusetts); Josh Bongard (Burlington, Vermont) |
| ABSTRACT | Disclosed are engineered multicellular organisms. Also disclosed are systems and methods for designing, preparing, and utilizing the engineered multicellular organisms. |
| FILED | Tuesday, January 12, 2021 |
| APPL NO | 18/003705 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/545 (20130101) Reclamation of Contaminated Soil B09C 1/10 (20130101) B09C 2101/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) Original (OR) Class C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235346 | STEPANOVA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina); INSTITUTE OF CYTOLOGY AND GENETICS, SIBERIAN BRANCH OF RUSSIAN ACADEMY OF SCIENCES (NOVOSIBIRSK, Russian Federation) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anna N. STEPANOVA (Cary, North Carolina); Jose M. ALONSO (Cary, North Carolina); Josefina Patricia FERNANDEZ-MORENO (Raleigh, North Carolina); Elena ZEMLYANSKAYA (Novosibirsk, Russian Federation); Victor LEVITSKY (Novosibirsk, Russian Federation) |
| ABSTRACT | ABSTRACT |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 18/002134 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/20 (20180501) A01H 6/823 (20180501) A01H 6/825 (20180501) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8238 (20130101) Original (OR) Class C12N 15/8242 (20130101) C12N 2320/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235347 | NEUMANN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (KSURF) (Manhattan, Kansas); NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas G. NEUMANN (Manhattan, Kansas); Tara J. NAZARENUS (Lincoln, Nebraska); Jose A. AZNAR-MORENO (Manhattan, Kansas); Timothy P. DURRETT (Manhattan, Kansas); Edgar B. CAHOON (Lincoln, Nebraska) |
| ABSTRACT | The present invention provides isolated FAD2, FAD3, FAB1 and FAE1 genes and FAD2, FAD3, FAB1 and FAE1 protein sequences of Camelina species, e.g., Camelina sativa, mutations in Camelina FAD2, FAD3, FAB1 and FAE1 genes, and methods of using the same. In addition, methods of altering Camelina seed composition and/or improving Camelina seed oil quality are disclosed. Furthermore, methods of breeding Camelina cultivars to produce plants having altered or improved seed oil and/or meal quality are provided. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/770466 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/1029 (20130101) C12N 15/8247 (20130101) Original (OR) Class Enzymes C12Y 114/19003 (20130101) C12Y 203/01179 (20130101) C12Y 203/01199 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235348 | Martienssen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York); Cambridge Enterprise Limited (Cambridge, United Kingdom) |
| ASSIGNEE(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York); Cambridge Enterprise Limited (Cambridge, United Kingdom) |
| INVENTOR(S) | Robert Martienssen (Cold Spring Harbor, New York); Charles Underwood (Cold Spring Harbor, New York); Ian Henderson (Cambridge, United Kingdom) |
| ABSTRACT | The present disclosure provides methods for increasing meiotic recombination in crop plants, as well as plants and seeds produced by such methods. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/813577 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/8218 (20130101) C12N 15/8261 (20130101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 40/146 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235368 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| ASSIGNEE(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| INVENTOR(S) | Jong-Won LEE (Knoxville, Tennessee); Cong T. TRINH (Knoxville, Tennessee) |
| ABSTRACT | Methods of microbial screening for identifying alcohol acyltransferases for ester biosynthesis and submodules for ester pathways to produce butyryl-coenzyme A derived esters are disclosed. The method includes the introduction preselected plasmids into a respective host strain to form engineered microbes, in situ fermentation thereof followed by a colorimetric assay for quantification of production of the target ester. In situ fermentation includes inoculating each well of a microplate that have a culture media for producing target esters with one of the engineered microbes, adding an overlay of a solvent to each, and incubating the same. The colorimetric assay includes transfer of a quantity of the overlay from each well to respective clean wells of a new microplate, treatment of each well to form an iron-hydroxamic acid complex aqueous phase, centrifugation of the microplate, and measurement of the absorbance at 520 nm and comparison to a standard curve for the target ester. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/822547 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/52 (20130101) C12N 15/1058 (20130101) C12N 15/1089 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/62 (20130101) Original (OR) Class Enzymes C12Y 101/01 (20130101) C12Y 102/0101 (20130101) C12Y 102/04001 (20130101) C12Y 203/01009 (20130101) C12Y 203/01075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235444 | STOLLENWERK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Northern Iowa Research Foundation (Cedar Falls, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANDREW STOLLENWERK (Cedar Falls, Iowa); TIMOTHY KIDD (Cedar Falls, Iowa) |
| ABSTRACT | The present disclosure relates generally to thin metal films having an ultra-flat surface and methods of their preparation. In particular, the ultra-flat thin metal films comprise FCC metals. Preferably, the thin metal films are attached to a substrate. Preferred substrates comprise chalcogenides and dichalcogenides. Beneficially, the thin metal films described herein can be prepared at ambient temperatures. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/184423 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/0005 (20130101) C23C 14/30 (20130101) C23C 14/34 (20130101) C23C 14/185 (20130101) Original (OR) Class C23C 14/5806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235480 | Bayram et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Can Bayram (Champaign, Illinois); Muhammad Ali Johar (Urbana, Illinois) |
| ABSTRACT | A wafer includes a buried substrate; a first layer of silicon (100) disposed on the buried substrate that includes silicon sidewalls (111) at an angle to the buried substrate and that form a bottom of each of multiple U-shaped grooves; a second layer of patterned oxide disposed on the silicon (100) that provides vertical sidewalls of each U-shaped groove formed within the first and second layers; a third layer of a buffer covering the first layer and partially covering the second layer partway up the vertical sidewalls; and multiple gallium nitride (GaN)-based structures disposed within the multiple U-shaped grooves, the multiple GaN-based structures each including cubic gallium nitride (c-GaN) formed at merged growth fronts of hexagonal gallium nitride (h-GaN) that extend from the silicon sidewalls (111). |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/098447 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/16 (20130101) C30B 25/183 (20130101) C30B 29/406 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236016 | Troncoso Aldas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nelson Daniel Troncoso Aldas (University Park, Pennsylvania); Vijaykrishnan Narayanan (University Park, Pennsylvania) |
| ABSTRACT | A system, device, application stored on non-transitory memory, and method can be configured to help a user of a device locate and pick up objects around them. Embodiments can be configured to help vision-impaired users find, locate, and pickup objects near them. Embodiments can be configured so that such functionality is provided locally via a single device so the device is able to provide assistance and hand guidance without a connection to the internet, a network, or another device (e.g. a remote server, a cloud based server, a server connectable to the device via an application programming interface, API, etc.). |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 18/011996 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/20 (20130101) Original (OR) Class Electric Digital Data Processing G06F 3/016 (20130101) G06F 3/167 (20130101) G06F 3/0484 (20130101) G06F 3/04817 (20130101) Image Data Processing or Generation, in General G06T 7/73 (20170101) G06T 2200/24 (20130101) G06T 2207/20092 (20130101) G06T 2207/30244 (20130101) Image or Video Recognition or Understanding G06V 20/50 (20220101) Telephonic Communication H04M 1/72403 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236215 | Strong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Reg. of the Univ. of Colorado, a body corp. (Denver, Colorado); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth F. Strong (Boulder, Colorado); Gregory B. Rieker (Boulder, Colorado); Juliet T. Gopinath (Boulder, Colorado); Alexander Anderson (Boulder, Colorado); Michael P. Brenner (Cambrdige, Massachusetts) |
| ABSTRACT | A structured-light-velocimetry method includes extracting one or more bursts from a time-varying signal generated by detecting scattered light from a tracer particle passing through a structured optical beam; fitting each of the one or more bursts to a multi-variable model to extract a plurality of fitted parameters; and executing a machine-learning model with the plurality of fitted parameters to predict an angular velocity of the tracer particle. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/998262 |
| CURRENT CPC | Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 1/06 (20130101) G01P 3/36 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236271 | Fessler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Allen Fessler (Ann Arbor, Michigan); Douglas Clair Noll (Ann Arbor, Michigan); Guanhua Wang (Ann Arbor, Michigan) |
| ABSTRACT | The following relates generally to accelerated magnetic resonance imaging (MRI) reconstruction. In some embodiments, a MRI machine learning algorithm is trained based on reference MRI data in non-Cartesian k-space. During the training, at each iteration of a plurality of iterations: (i) a non-Cartesian sampling trajectory ω may be optimized under the physical constraints, and/or (ii) an image reconstructor may be jointly iteratively optimized. Examples of the image reconstructor include a convolutional neural network (CNN) denoiser, a model-based deep learning (MoDL) image reconstructor, iterative image reconstructor, a regularizer, and an invertible neural network. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/097632 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4826 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/20 (20130101) G06T 11/008 (20130101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237331 | Iandola et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tesla, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Forrest Nelson Iandola (San Jose, California); Harsimran Singh Sidhu (Fremont, California); Yiqi Hou (Berkeley, California) |
| ABSTRACT | A neural network architecture is used that reduces the processing load of implementing the neural network. This network architecture may thus be used for reduced-bit processing devices. The architecture may limit the number of bits used for processing and reduce processing to prevent data overflow at individual calculations of the neural network. To implement this architecture, the number of bits used to represent inputs at levels of the network and the related filter masks may also be modified to ensure the number of bits of the output does not overflow the resulting capacity of the reduced-bit processor. To additionally reduce the load for such a network, the network may implement a “starconv” structure that permits the incorporation of nearby nodes in a layer to balance processing requirements and permit the network to learn from context of other nodes. |
| FILED | Thursday, January 19, 2023 |
| APPL NO | 18/156628 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/575 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237358 | KING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ATOM COMPUTING INC. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan KING (Berkeley, California); Benjamin BLOOM (Berkeley, California); Krish KOTRU (Berkeley, California); Brian LESTER (Berkeley, California); Maxwell PARSONS (Berkeley, California) |
| ABSTRACT | The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068408 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237363 | Oh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changhun Oh (Chicago, Illinois); Youngrong Lim (Seoul, South Korea); Yat Wong (Chicago, Illinois); William Fefferman (Chicago, Illinois); Liang Jiang (Chicago, Illinois) |
| ABSTRACT | This disclosure relates to a method and system for efficiently and analytically generating spectra associated with transitions between thermal states in a multi-mode bosonic system using a classical algorithm to compute Fourier components of the transition spectra of the multi-mode bosonic system based on a representation space sampling method inspired by quantum Gaussian boson sampling followed by an inverse Fourier transform. The disclosed method and system particularly apply to efficient estimation of molecular vibronic spectra. For example, an exact solution of the Fourier components of molecular vibronic spectra at zero temperature may be analytically computed in a representation space by using, for example, a positive P-representation of the multi-mode bosonic vibronic quantum states of the molecule. Such a method may be further applied to more general vibronic spectroscopy, such as computing molecular vibronic spectra at finite temperatures by introducing additional auxiliary bosonic modes and computing vibronic spectra associated with non-thermal states, such as Fock states. |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/156254 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/60 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238178 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Lu (Tallahassee, Florida); Iain R. Dixon (Tallahassee, Florida); Mark D. Bird (Tallahassee, Florida); Justin Deterding (Tallahassee, Florida); Hongyu Bai (Tallahassee, Florida); Emsley L. Marks (Tallahassee, Florida); William Denis Markiewicz (Tallahassee, Florida) |
| ABSTRACT | Coils for superconducting magnets and methods of making coils for superconducting magnets and controlling the turn-to-turn contact resistance of coils. The coils include a REBCO superconducting tape coated with a layer of tin-lead solder, co-wound with an oxidized stainless steel tape. The inclusion of tin-lead solder on the REBCO tape and a layer of oxidation on the stainless steel tape advantageously allow for tuning of the turn-to-turn contact resistance of the coil, and advantageously mitigates the effect of repeated pressure cycling on the turn-to-turn contact resistance. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/157146 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/06 (20130101) H01F 41/048 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238246 | Bayram et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illnois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Can Bayram (Champaign, Illinois); Muhammad Ali Johar (Urbana, Illinois) |
| ABSTRACT | A wafer includes a buried substrate; a layer of silicon (100) disposed on the buried substrate and forming multiple U-shaped grooves, wherein each U-shaped groove comprises a bottom portion and silicon sidewalls (111) at an angle to the buried substrate; a buffer layer disposed within the multiple U-shaped grooves; and multiple gallium nitride (GaN)-based structures having vertical sidewalls disposed within and protruding above the multiple U-shaped grooves, the multiple GaN-based structures each including cubic gallium nitride (c-GaN) formed at merged growth fronts of hexagonal gallium nitride (h-GaN) that extend from the silicon sidewalls (111). |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/098458 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0245 (20130101) H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02381 (20130101) H01L 21/02458 (20130101) H01L 21/02488 (20130101) H01L 21/02505 (20130101) H01L 21/02595 (20130101) H01L 21/02609 (20130101) H01L 21/31111 (20130101) Original (OR) Class H01L 21/32134 (20130101) H01L 33/007 (20130101) H01L 33/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238512 | Burns et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | David Burns (Baltimore, Maryland); Avery E. Baumann (Baltimore, Maryland); Van Sara Thoi (Baltimore, Maryland) |
| ABSTRACT | An electrode includes at least one of sulfur (S) or selenium (Se), and a functionalized metal organic framework (R-MOF), the functionalized metal organic framework (R-MOF) having a functional group (R) attached to an organic portion of a metal organic framework (MOF). The functionalized metal organic framework (R-MOF) is adapted to react with at least one of electrochemically accessible sulfur (S) or selenium (Se) to capture at least one of lithium polysulfide or sodium polysulfide via covalent attachment of sulfur (S) or selenium (Se), respectively, to the functional group (R) of the functionalized metal organic framework (R-MOF). |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 18/009659 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/60 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/382 (20130101) H01M 4/5815 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230239935 | Zhang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenghao Zhang (Tallahassee, Florida) |
| ABSTRACT | Provided are methods and apparatus for recovering collided packets in a wireless network, as well as for implementing block-based error correction techniques. In an example, provided is a method to recover collided packets by (A) assigning a peak of a collided packet to a respective packet by calculating a matching cost, per collided packet, from an amplitude of the peak and a time when the peak occurred, where the matching cost is determined from a combination of per-collided packet parameters including (i) respective estimated symbol boundaries of the collided packets, (ii) respective estimated Carrier Frequency Offsets of the collided packets, and (iii) a peak amplitude history of prior packets received from wireless network nodes, and (B) assigning, based on a respective packet in the collided packets having the parameters producing a lowest matching cost among the calculated matching costs, the peak to the respective packet. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100457 |
| CURRENT CPC | Wireless Communication Networks H04W 72/0453 (20130101) H04W 74/0841 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230233989 | McGrail et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | B. Peter McGrail (Pasco, Washington); Radha K. Motkuri (Richland, Washington) |
| ABSTRACT | An apparatus that includes (A) an atmospheric water extraction unit; and (B) a direct air capture unit positioned downstream of and in communication with the atmospheric water extraction unit, wherein the apparatus is capable of reversibly operating in (i) adsorption mode to adsorb water and CO2 from an incoming air stream and (ii) regeneration mode to release adsorbed water and CO2, wherein the atmospheric water extraction unit comprises a first desiccant bed comprising a sorbent that adsorbs water from an incoming air stream during adsorption mode and releases water during regeneration mode, and wherein the direct air capture unit comprises a first moisture-responsive CO2 sorbent bed comprising a sorbent that adsorbs CO2 from an air stream during adsorption mode and releases CO2 upon contact with water vapor during regeneration mode. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099550 |
| CURRENT CPC | Separation B01D 53/047 (20130101) B01D 53/261 (20130101) Original (OR) Class B01D 2257/80 (20130101) B01D 2257/504 (20130101) B01D 2259/40083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234003 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chong Liu (Chicago, Illinois); Eli Hoenig (Chicago, Illinois) |
| ABSTRACT | Molybdenum disulfide membranes for ionic and/or molecular filtration applications are provided. The membranes have high separation performance, including high water flux and high molecule and/or ion rejection, and do not need to be stored in a hydrated condition in order to enable their reuse. The membranes are based on stacked MoS2 sheets having small hydrophilic organic functional groups covalently bound thereto. |
| FILED | Wednesday, July 07, 2021 |
| APPL NO | 18/012078 |
| CURRENT CPC | Separation B01D 61/025 (20130101) B01D 67/0079 (20130101) B01D 71/022 (20130101) Original (OR) Class B01D 2323/36 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234035 | GU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan); University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuntao GU (Farmington Hills, Michigan); Wei LI (Troy, Michigan); Fudong LIU (Oviedo, Florida) |
| ABSTRACT | A layered catalyst structure for purifying an exhaust gas stream includes a catalyst support and a palladium catalyst layer including an atomic dispersion of palladium ions electrostatically adsorbed onto an exterior surface of the catalyst support. The catalyst support includes an alumina substrate, a first ceria layer disposed on and extending substantially continuously over the alumina substrate, and a second colloidal ceria layer formed directly on the first ceria layer over the alumina substrate. The palladium catalyst layer is formed on the exterior surface of the catalyst support by applying a palladium-containing precursor solution to the exterior surface of the catalyst support and then heating the catalyst support and the palladium-containing precursor solution. The palladium-containing precursor solution includes a positively charged palladium complex in an aqueous medium and has a pH greater than a point of zero charge of the second colloidal ceria layer. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581447 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 23/10 (20130101) B01J 23/44 (20130101) Original (OR) Class B01J 35/0006 (20130101) B01J 35/1014 (20130101) B01J 35/1042 (20130101) B01J 37/08 (20130101) B01J 37/0215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234042 | Kidder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle K. Kidder (Oak Ridge, Tennessee); Luke Daemen (Oak Ridge, Tennessee) |
| ABSTRACT | A catalytic carbon capture material is provided. The catalytic carbon capture material includes a microporous polymer including a Tröger's base moiety, and a transition metal is coordinated within the microporous polymer. The catalytic carbon capture material selectively captures carbon dioxide (CO2) and also is a catalyst that simultaneously converts the captured carbon dioxide into one or more carbon dioxide-based products. A method of making the catalytic carbon capture material and a method of selective carbon dioxide capture and conversion are also provided. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/100664 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1658 (20130101) Original (OR) Class B01J 35/026 (20130101) B01J 35/065 (20130101) B01J 35/1019 (20130101) B01J 35/1023 (20130101) B01J 37/04 (20130101) B01J 37/06 (20130101) B01J 37/009 (20130101) B01J 2231/625 (20130101) B01J 2531/821 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234095 | Chapaton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Thomas J. Chapaton (Sterling Heights, Michigan); Peter P. Andruskiewicz, IV (Ann Arbor, Michigan) |
| ABSTRACT | A method for preparing a metallic surface of a device includes executing iterations of a first cleaning regimen and executing iterations of a second cleaning regimen. The first cleaning regimen includes applying a hydrocarbon solvent, e.g., an iso-octane solution, to the metallic surface of the device, executing a first sonication event on the device, and rinsing the metallic surface of the device. The second cleaning regimen includes applying a solution of chlorinated solvent to the metallic surface of the device, executing a second sonication event on the device, and rinsing the metallic surface of the device. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586037 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 3/12 (20130101) B05D 3/102 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234115 | Kappagantula et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Keerti S. Kappagantula (Richland, Washington); Glenn J. Grant (Benton City, Washington); Aditya K. Nittala (Richland, Washington); Xiao Li (Richland, Washington); MD. Reza-E-Rabby (Richland, Washington); WoongJo Choi (Richland, Washington); Bharat Gwalani (Cary, North Carolina); Joshua A. Silverstein (Richland, Washington) |
| ABSTRACT | An extrusion feedstock material is provided, the material comprising a length of one material extending from a first end to a second end; and at least one slot extending lengthwise within the one material between the first and second ends of the material. A process for extruding conductive material is also provided, the process comprising providing both rotational and axial forces between a die tool and a length of feedstock material to form an extrusion product, wherein the length of feedstock and conductive material comprise Al and NanoCrystalline Carbon Forms (NCCF). A process for extruding material is provided, the process comprising: providing both rotational and axial forces between a die tool and a length of feedstock material to form an extrusion product, wherein the length of feedstock material comprises: a length of material extending from a first end to a second end; and at least one slot extending lengthwise within the material between the first and second ends of the material. A conductive extrudate material is provided comprising Al and NanoCrystalline Carbon Forms (NCCF). |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/121563 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/001 (20130101) B21C 23/01 (20130101) B21C 23/002 (20130101) Original (OR) Class B21C 23/08 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/182 (20170801) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/04 (20130101) C22F 1/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234862 | Mededovic Thagard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Selma Mededovic Thagard (Potsdam, New York); Mikhail Vasilev (Potsdam, New York) |
| ASSIGNEE(S) | CLARKSON UNIVERSITY (POTSDAM, New York) |
| INVENTOR(S) | Selma Mededovic Thagard (Potsdam, New York); Mikhail Vasilev (Potsdam, New York) |
| ABSTRACT | An annular bubbling electric discharge reactor for treating water includes a non-conductive pipe having a top and a bottom with a gas sparger installed within the non-conductive pipe and positioned adjacent the bottom and adapted to generate bubbles or foam and control the bubble size formation. A high voltage electrode is fixed concentrically within the non-conductive pipe and a ground electrode is fixed at an intermediate position within the non-conductive pipe and in circumferential relation to the high voltage electrode with an annular space defined between the ground electrode and high voltage electrode. A liquid inlet and a liquid outlet are provided to allow polluted liquid/water into the reactor and discharge treated liquid/water therefrom. A circuit and power supply are provided for generating an electrical discharge between the high voltage electrode and ground electrode, thereby creating a plasma generation region where the liquid is treated. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100490 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/30 (20130101) C02F 1/4608 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230234900 | Gunnoe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Brent Gunnoe (Palmyra, Virginia); Xiaofan Jia (Hamden, Connecticut); Lucas Isaac Frye (Princeton, New Jersey) |
| ABSTRACT | The present disclosure provides for a rhodium-catalyzed oxidative arene alkenylation from arenes and styrenes to prepare stilbene and stilbene derivatives. For example, the present disclosure provides for method of making arenes or substituted arenes, in particular stilbene and stilbene derivatives, from a reaction of an optionally substituted arene and/or optionally substituted styrene. The reaction includes a Rh catalyst or Rh pre-catalyst material and an oxidant, where the Rh catalyst or Rh catalyst formed Rh pre-catalyst material selectively functionalizes CH bond on the arene compound (e.g., benzene or substituted benzene). |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/999273 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2213 (20130101) B01J 31/2291 (20130101) B01J 2231/4261 (20130101) B01J 2531/0208 (20130101) B01J 2531/822 (20130101) Acyclic or Carbocyclic Compounds C07C 2/84 (20130101) Original (OR) Class C07C 17/266 (20130101) C07C 41/30 (20130101) C07C 201/12 (20130101) C07C 253/30 (20130101) C07C 2523/46 (20130101) Heterocyclic Compounds C07D 307/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235347 | NEUMANN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (KSURF) (Manhattan, Kansas); NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas G. NEUMANN (Manhattan, Kansas); Tara J. NAZARENUS (Lincoln, Nebraska); Jose A. AZNAR-MORENO (Manhattan, Kansas); Timothy P. DURRETT (Manhattan, Kansas); Edgar B. CAHOON (Lincoln, Nebraska) |
| ABSTRACT | The present invention provides isolated FAD2, FAD3, FAB1 and FAE1 genes and FAD2, FAD3, FAB1 and FAE1 protein sequences of Camelina species, e.g., Camelina sativa, mutations in Camelina FAD2, FAD3, FAB1 and FAE1 genes, and methods of using the same. In addition, methods of altering Camelina seed composition and/or improving Camelina seed oil quality are disclosed. Furthermore, methods of breeding Camelina cultivars to produce plants having altered or improved seed oil and/or meal quality are provided. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/770466 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/1029 (20130101) C12N 15/8247 (20130101) Original (OR) Class Enzymes C12Y 114/19003 (20130101) C12Y 203/01179 (20130101) C12Y 203/01199 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235368 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| ASSIGNEE(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| INVENTOR(S) | Jong-Won LEE (Knoxville, Tennessee); Cong T. TRINH (Knoxville, Tennessee) |
| ABSTRACT | Methods of microbial screening for identifying alcohol acyltransferases for ester biosynthesis and submodules for ester pathways to produce butyryl-coenzyme A derived esters are disclosed. The method includes the introduction preselected plasmids into a respective host strain to form engineered microbes, in situ fermentation thereof followed by a colorimetric assay for quantification of production of the target ester. In situ fermentation includes inoculating each well of a microplate that have a culture media for producing target esters with one of the engineered microbes, adding an overlay of a solvent to each, and incubating the same. The colorimetric assay includes transfer of a quantity of the overlay from each well to respective clean wells of a new microplate, treatment of each well to form an iron-hydroxamic acid complex aqueous phase, centrifugation of the microplate, and measurement of the absorbance at 520 nm and comparison to a standard curve for the target ester. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/822547 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/52 (20130101) C12N 15/1058 (20130101) C12N 15/1089 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/62 (20130101) Original (OR) Class Enzymes C12Y 101/01 (20130101) C12Y 102/0101 (20130101) C12Y 102/04001 (20130101) C12Y 203/01009 (20130101) C12Y 203/01075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235432 | Ott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa state university research foundation, Inc. (Ames, Iowa); Lawrence Livermore National Security, LLC (Livermore, California); UT- Battelle, LLC (Oak Ridge, Tennessee); Eck Industries, Inc. (Manitowoc, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan T. Ott (Ames, Iowa); Fanqiang Meng (Zhuhai, China PRC); Scott K. McCall (Livermore, California); Hunter B. Henderson (Livermore, California); Oriando Rios (Knoxville, Tennessee); Zachary C. Sims (Knoxville, Tennessee); David Weiss (Manitowoc, Wisconsin) |
| ABSTRACT | MMC’s comprising an Al—RE alloy-based matrix and ceramic, metal and/or intermetallic reinforcement particulates dispersed in the alloy matrix provide improved strength and ductility wherein the reinforcement particulates have a higher melting temperature than the matrix alloy. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 17/803924 |
| CURRENT CPC | Alloys C22C 1/051 (20130101) C22C 32/0036 (20130101) Original (OR) Class C22C 32/0063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235450 | Lenert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrej Lenert (Ann Arbor, Michigan); Neil P. Dasgupta (Ann Arbor, Michigan); Zachary James Berquist (Ann Arbor, Michigan); Andrew Gayle (Ann Arbor, Michigan) |
| ABSTRACT | Thermally insulating materials (TIMs) for use in concentrated solar thermal (CST) technologies comprising a mesoporous oxide including a porous oxide matrix comprising a porous oxide and a metal oxide or metal nitride in the form of a conformal layer of the metal oxide or metal nitride on the surface of the porous oxide matrix, wherein the conformal layer completely covers the surface area of the porous oxide matrix, or in the form of metal oxide or metal nitride nanoparticles dispersed throughout the porous oxide matrix, or in the form of a conformal coating or nanoparticles, methods of preparing same, and solar devices comprising same. |
| FILED | Friday, June 18, 2021 |
| APPL NO | 18/010978 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/045 (20130101) Original (OR) Class C23C 16/403 (20130101) C23C 16/45527 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 80/52 (20180501) F24S 80/56 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235477 | GARCIA-DIAZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BRENDA L. GARCIA-DIAZ (AIKEN, South Carolina); CHRISTOPHER S. DANDENEAU (AUGUSTA, Georgia); DALE A. HITCHCOCK (AIKEN, South Carolina) |
| ABSTRACT | Methods and systems for use in targeted removal of metals from a substrate via electrorefining are described. A self-propagating reaction is initiated by use of a thermite to reach high temperatures sufficient to induce localized melting of a salt situated on a metal or alloy substrate. Using a power supply connected to an electrode assembly, an electrorefining reaction capable of generating significant localized corrosion of the substrate is produced. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/097731 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 33/02 (20130101) Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 3/32 (20130101) C25C 7/005 (20130101) Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235480 | Bayram et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Can Bayram (Champaign, Illinois); Muhammad Ali Johar (Urbana, Illinois) |
| ABSTRACT | A wafer includes a buried substrate; a first layer of silicon (100) disposed on the buried substrate that includes silicon sidewalls (111) at an angle to the buried substrate and that form a bottom of each of multiple U-shaped grooves; a second layer of patterned oxide disposed on the silicon (100) that provides vertical sidewalls of each U-shaped groove formed within the first and second layers; a third layer of a buffer covering the first layer and partially covering the second layer partway up the vertical sidewalls; and multiple gallium nitride (GaN)-based structures disposed within the multiple U-shaped grooves, the multiple GaN-based structures each including cubic gallium nitride (c-GaN) formed at merged growth fronts of hexagonal gallium nitride (h-GaN) that extend from the silicon sidewalls (111). |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/098447 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/16 (20130101) C30B 25/183 (20130101) C30B 29/406 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235976 | Kirsch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Technologies Corporation (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Waltham, Massachusetts) |
| INVENTOR(S) | Kathryn L. Kirsch (Manchester, Connecticut); Robert H. Dold (Monson, Massachusetts); Paul Attridge (Colchester, Connecticut); Alexandru Cadar (Eastford, Connecticut) |
| ABSTRACT | In accordance with at least one aspect of this disclosure, a transition structure for a heat exchanger can include a body defining a dome cavity. The dome cavity can be configured to transition flow between at least one first channel and a plurality of second channels having a different number than the at least one first channel. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581571 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 9/026 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236119 | Taleyarkhan |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Rusi P. Taleyarkhan (Lafayette, Indiana) |
| ABSTRACT | The system includes a tensioned metastable fluid detector apparatus, a mixing chamber, and a processor. The processor is communicatively coupled to the tensioned metastable fluid detector apparatus. The processor executes steps to form an isotope detection rate versus negative pressure response curve and to determine the isotopic ratio. The mixing chamber is selectively coupled to the tensioned metastable fluid detector apparatus. The mixing chamber is configured to prepare a sample for tensioned metastable fluid detector analysis. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099325 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 21/35 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236331 | Fronk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan G. Fronk (Idaho Falls, Idaho); Matthew W. Anderson (Idaho Falls, Idaho); Michael A. Reichenberger (Idaho Falls, Idaho); Edward L. Reber (Idaho Falls, Idaho); Dawn M. Scates (Idaho Falls, Idaho); Graeme M. Holliday (Idaho Falls, Idaho) |
| ABSTRACT | This application relates generally to improving energy resolution of measured energy data. One or more embodiments includes a method including obtaining first energy data representative of amounts of energy measured at a first number of energy levels. The method may also include generating second energy data based on the first energy data. The second energy data may be representative of amounts of energy at a second number of energy levels. The second energy data may exhibit a higher energy resolution than the first energy data. Related devices, systems and methods are also disclosed. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/649031 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/244 (20130101) Original (OR) Class G01T 1/2023 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237363 | Oh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changhun Oh (Chicago, Illinois); Youngrong Lim (Seoul, South Korea); Yat Wong (Chicago, Illinois); William Fefferman (Chicago, Illinois); Liang Jiang (Chicago, Illinois) |
| ABSTRACT | This disclosure relates to a method and system for efficiently and analytically generating spectra associated with transitions between thermal states in a multi-mode bosonic system using a classical algorithm to compute Fourier components of the transition spectra of the multi-mode bosonic system based on a representation space sampling method inspired by quantum Gaussian boson sampling followed by an inverse Fourier transform. The disclosed method and system particularly apply to efficient estimation of molecular vibronic spectra. For example, an exact solution of the Fourier components of molecular vibronic spectra at zero temperature may be analytically computed in a representation space by using, for example, a positive P-representation of the multi-mode bosonic vibronic quantum states of the molecule. Such a method may be further applied to more general vibronic spectroscopy, such as computing molecular vibronic spectra at finite temperatures by introducing additional auxiliary bosonic modes and computing vibronic spectra associated with non-thermal states, such as Fock states. |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/156254 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/60 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238153 | LEVITT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Joseph LEVITT (Seattle, Washington); Matthew Colin THOMPSON (Mukilteo, Washington) |
| ABSTRACT | Methods and systems are provided for Z-pinch plasma and other plasma confinement utilizing various electrode compositions and configurations. In one example, a plasma confinement system includes a plurality of electrodes, each electrode of the plurality of electrodes arranged coaxially with respect to an assembly region of the plasma confinement system and positioned so as to be exposed to the assembly region, wherein one or more electrodes of the plurality of electrodes includes an electrode material which releases hydrogen gas above a threshold temperature. In an additional or alternative example, a plasma confinement system includes an electrode body including a nosecone, and a liquid metal, a portion of the liquid metal forming a protective film between a surface of the nosecone and an exterior of the nosecone during operation of the plasma confinement system. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/101081 |
| CURRENT CPC | Fusion Reactors G21B 1/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238154 | THOMPSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Colin THOMPSON (Mukilteo, Washington); Benjamin Joseph LEVITT (Seattle, Washington) |
| ABSTRACT | Methods and systems are provided for Z-pinch plasma and other plasma confinement utilizing various electrode compositions and configurations. In one example, a plasma confinement system includes a plurality of electrodes, each electrode of the plurality of electrodes arranged coaxially with respect to an assembly region of the plasma confinement system and positioned so as to be exposed to the assembly region, wherein one or more electrodes of the plurality of electrodes includes an electrode material which releases hydrogen gas above a threshold temperature. In an additional or alternative example, a plasma confinement system includes an electrode body including a nosecone, and a liquid metal, a portion of the liquid metal forming a protective film between a surface of the nosecone and an exterior of the nosecone during operation of the plasma confinement system. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/101086 |
| CURRENT CPC | Fusion Reactors G21B 1/03 (20130101) G21B 1/15 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238206 | Mustapha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brahim Mustapha (Naperville, Illinois); Jerry A. Nolen, JR. (Chicago, Illinois); Rainer Meinke (Melbourne, Florida) |
| ABSTRACT | A compact two-dimensional (2D) scanning magnet for scanning ion beams is provided. The compact 2D scanning magnet may include an outer double-helix coil and an inner double-helix coil that is disposed within the outer double-helix coil and is rotated about an axis relative to the outer double-helix coil. The outer double-helix coil may include a first outer coil configured to receive an input electrical current through the first outer coil in a first direction, and a second outer coil configured to receive the input electrical current through the second outer coil in a second direction. The inner double-helix coil may include a first inner coil configured to receive a second input electrical current through the first inner coil in the first direction, and a second inner coil configured to receive the second input electrical current through the second inner coil in the second direction. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/101672 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/08 (20130101) H01J 37/141 (20130101) H01J 37/1475 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238246 | Bayram et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illnois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Can Bayram (Champaign, Illinois); Muhammad Ali Johar (Urbana, Illinois) |
| ABSTRACT | A wafer includes a buried substrate; a layer of silicon (100) disposed on the buried substrate and forming multiple U-shaped grooves, wherein each U-shaped groove comprises a bottom portion and silicon sidewalls (111) at an angle to the buried substrate; a buffer layer disposed within the multiple U-shaped grooves; and multiple gallium nitride (GaN)-based structures having vertical sidewalls disposed within and protruding above the multiple U-shaped grooves, the multiple GaN-based structures each including cubic gallium nitride (c-GaN) formed at merged growth fronts of hexagonal gallium nitride (h-GaN) that extend from the silicon sidewalls (111). |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/098458 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0245 (20130101) H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02381 (20130101) H01L 21/02458 (20130101) H01L 21/02488 (20130101) H01L 21/02505 (20130101) H01L 21/02595 (20130101) H01L 21/02609 (20130101) H01L 21/31111 (20130101) Original (OR) Class H01L 21/32134 (20130101) H01L 33/007 (20130101) H01L 33/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238328 | ALBERI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirstin ALBERI (Denver, Colorado); Anthony D. RICE (Denver, Colorado); Brian Darrius FLUEGEL (Golden, Colorado); Choong Hee LEE (Frisco, Texas) |
| ABSTRACT | Described herein are devices and methods that utilize three-dimensional topological semimetals (including Dirac, Weyl and nodal line) that may be useful in advanced electronic devices. The Fermi level in three dimensional topological semimetals can be significantly shifted in energy when forming a heterojunction with a semiconductor or metal. This has unintended and sometimes negative consequences for device performance. Described herein are designs and methods to modify the heterostructures to either suppress Fermi level movement or to produce an intentional shift to allow for the use of these improved semimetal devices. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099559 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/53271 (20130101) Original (OR) Class H01L 29/7786 (20130101) H01L 31/02161 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238871 | ALAHYARI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | ABBAS A. ALAHYARI (Glastonbury, Connecticut); PARAG M. KSHIRSAGAR (South Windsor, Connecticut) |
| ABSTRACT | A cooling system for a superconducting electric machine may comprise a fluid reservoir and a first fluid comprising a first mixture of hydrogen and helium configured to be stored in the fluid reservoir. A plurality of conduits may be fluidly coupled to the fluid reservoir and may form a closed loop between the fluid reservoir and the superconducting electric machine. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581572 |
| CURRENT CPC | Dynamo-electric Machines H02K 9/20 (20130101) H02K 55/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230234125 | Hosek |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Persimmon Technologies Corporation (Wakefield, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Hosek (Salem, New Hampshire) |
| ABSTRACT | A system for forming a bulk material having insulated boundaries from a metal material and a source of an insulating material is provided. The system includes a heating device, a deposition device, a coating device, and a support configured to support the bulk material. The heating device heats the metal material to form particles having a softened or molten state and the coating device coats the metal material with the insulating material from the source and the deposition device deposits particles of the metal material in the softened or molten state on the support to form the bulk material having insulated boundaries. |
| FILED | Friday, March 17, 2023 |
| APPL NO | 18/122808 |
| CURRENT CPC | Apparatus for Applying Fluent Materials to Surfaces, in General B05C 5/001 (20130101) B05C 5/002 (20130101) Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 23/003 (20130101) Original (OR) Class Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/115 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/18 (20130101) C23C 6/00 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/24 (20130101) H01F 3/08 (20130101) H01F 41/0246 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24413 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235065 | Wu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cancure, LLC (Shoreline, Washington) |
| ASSIGNEE(S) | Cancure, LLC (Shoreline, Washington) |
| INVENTOR(S) | Jennifer Wu (Wilmette, Illinois) |
| ABSTRACT | The present invention provides MIC antibodies, antigen binding portions thereof and MIC binding agents thereof for use in the treatment of cancer. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049434 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2833 (20130101) Original (OR) Class C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237331 | Iandola et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tesla, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Forrest Nelson Iandola (San Jose, California); Harsimran Singh Sidhu (Fremont, California); Yiqi Hou (Berkeley, California) |
| ABSTRACT | A neural network architecture is used that reduces the processing load of implementing the neural network. This network architecture may thus be used for reduced-bit processing devices. The architecture may limit the number of bits used for processing and reduce processing to prevent data overflow at individual calculations of the neural network. To implement this architecture, the number of bits used to represent inputs at levels of the network and the related filter masks may also be modified to ensure the number of bits of the output does not overflow the resulting capacity of the reduced-bit processor. To additionally reduce the load for such a network, the network may implement a “starconv” structure that permits the incorporation of nearby nodes in a layer to balance processing requirements and permit the network to learn from context of other nodes. |
| FILED | Thursday, January 19, 2023 |
| APPL NO | 18/156628 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/575 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237358 | KING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ATOM COMPUTING INC. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan KING (Berkeley, California); Benjamin BLOOM (Berkeley, California); Krish KOTRU (Berkeley, California); Brian LESTER (Berkeley, California); Maxwell PARSONS (Berkeley, California) |
| ABSTRACT | The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068408 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230237759 | BUCKLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); Mark A. BUCKLER (Wenham, Massachusetts); Vladimir VALTCHINOV (Waban, Massachusetts); David S. PAIK (Moon Bay, California) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, February 08, 2023 |
| APPL NO | 18/166284 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) Original (OR) Class G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230238099 | BEESON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Simphotek, Inc. (Newark, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl BEESON (Princeton, New Jersey); Evgueni PARILOV (Brooklyn, New York); Mary POTASEK (Princeton, New Jersey) |
| ABSTRACT | A method of administering interstitial photodynamic therapy to a target region of a patient may include receiving information associated with the target region, an initial photosensitizer concentration, a plurality of initial photosensitizer photokinetic rate parameters, and a threshold treatment dose for a photosensitizer, the threshold treatment dose being a threshold photodynamic therapy-dose or a threshold reactive oxygen species dose. A location in the target region for inserting at least one interstitial treatment fiber to deliver the treatment light, and initial values for treatment light transmission is determined. Computational spatial elements are determined for the target region and for the location of emitting surfaces of the at least one interstitial treatment fiber, and a light fluence rate for delivering treatment light to each of the computational spatial elements. A treatment dose is determined based on the light fluence rate, the plurality of photosensitizer photokinetic rate parameters, and a photokinetic rate equation. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 18/041079 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 5/067 (20210801) A61N 5/0601 (20130101) A61N 2005/063 (20130101) A61N 2005/0626 (20130101) A61N 2005/0651 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230233548 | Cardozo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Cardozo (Bronx, New York); Carlos A. Toro-Chacon (Bronx, New York); Zachary Graham (Birmingham, Alabama); Wei Zhao (Bronx, None); Juan C. Saez (Vina del Mar, Chile) |
| ABSTRACT | Provided are methods of treating an injury to the nervous system in a subject comprising administering to the subject an effective amount of boldine, a boldine analog, or a pharmaceutically-acceptable salt thereof. Also provided are methods of improving voluntary muscle control and methods of treating neuropathic pain in a subject having an injury to the nervous system. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Thursday, March 23, 2023 |
| APPL NO | 18/125612 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233580 | Ren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Durect Corporation (Cupertino, California); Virginia Commonwealth University (Richmond, Virginia); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shunlin Ren (Richmond, Virginia); Yaping Wang (Richmond, Virginia); WeiQi Lin (Emerald Hills, California) |
| ABSTRACT | Aspects of the present disclosure include methods for treating at least one of cancer and non-cancerous transformation related to Epstein-Barr virus, such as at least one of Hodgkin's lymphoma, soft tissue sarcoma, leiomyosarcoma, nasopharyngeal carcinoma, Burkitt's lymphoma, T-cell lymphoma, gastric carcinoma, invasive breast cancer, and hierarchically organized carcinoma. Hierarchically organized carcinomas include, but are not limited to, pancreatic ductal adenocarcinoma, urothelial cancer, colorectal cancer, head and neck cancer, non-small cell lung cancer, esophagus cancer, breast cancer, thyroid cancer, oral cancer, cervical cancer, ovarian cancer, and liver cancer. In practicing the subject methods, an effective amount of at least one compound selected from 25-hydroxycholesterol-3-sulfate (25HC3S), 25-hydroxycholesterol-disulfate (25HCDS), 27-hydroxycholesterol-3-sulfate (27HC3S), 27-hydroxycholesterol-disulfate (27HCDS), 24-hydroxycholesterol-3-sulfate (24HC3S), 24-hydroxycholesterol-disulfate (24HCDS), and 24,25-epoxycholesterol-3-sulfate, or salt thereof is administered to the subject. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 18/008585 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/575 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233594 | Kraemer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Kraemer (Kent, Washington); Jeanna M. Wheeler (Seattle, Washington); Pamela McMillan (Seattle, Washington); Timothy J. Strovas (Algona, Washington); Jeremy Baker (Seattle, Washington) |
| ABSTRACT | Described herein are compositions and methods for treating Alzheimer's disease or dementia. The compositions include mammalian suppressor of taupathy 2 inhibitors (MSUT2). The MSUT2 inhibitors can be small interfering RNAs, guide RNAs, or small molecules. The methods include reducing accumulation of phosphorylated and aggregated human tau. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/929867 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/26 (20130101) A61K 31/41 (20130101) A61K 31/713 (20130101) Original (OR) Class A61K 31/4745 (20130101) A61K 31/7105 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2740/15043 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235022 | SEN GUPTA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); The United States Govemment as Represented by the Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anirban SEN GUPTA (Cleveland, Ohio); Evi STAVROU (Cleveland, Ohio) |
| ABSTRACT | Targeting or binding peptides to neutrophil elastase for specific targeting of activated neutrophils includes amino acid sequences substantially similar to a reactive center loop portion of alpha-1 anti-trypsin (AAT). |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/793545 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6911 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/811 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236193 | IVERSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tina IVERSON (Nashville, Tennessee); Barbara BENSING (San Francisco, California); Paul SULLAM (San Francisco, California) |
| ABSTRACT | Disclosed are compositions and methods related to the use of sialoglycan as markers for the diagnosis and prognosis of cancers and inflammatory conditions. In one aspect, also disclosed herein are engineered probes and chimeric probes with differential binding ability to sialoglycans. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/009956 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/535 (20130101) G01N 33/57484 (20130101) Original (OR) Class G01N 2440/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230232788 | Kraayenbrink et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Ann Kraayenbrink (Ames, Iowa); Anna Butters-Johnson (Ames, Iowa); Derek Kraayenbrink (Ames, Iowa) |
| ABSTRACT | An apparatus, systems, and methods of providing enrichment to poultry during raising or maintaining of the poultry. One or more light sources project beams to generate laser spots at and around the poultry. A control regimen moves the light spots relative the poultry in generally random fashion during timed sessions for each given time period (e.g. each day). The spot movement is designed to promote benefits to poultry and producer in correlation to experimental data related to animal welfare, health, and commercial value. |
| FILED | Wednesday, December 28, 2022 |
| APPL NO | 18/147541 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 15/027 (20130101) Original (OR) Class A01K 39/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235347 | NEUMANN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (KSURF) (Manhattan, Kansas); NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas G. NEUMANN (Manhattan, Kansas); Tara J. NAZARENUS (Lincoln, Nebraska); Jose A. AZNAR-MORENO (Manhattan, Kansas); Timothy P. DURRETT (Manhattan, Kansas); Edgar B. CAHOON (Lincoln, Nebraska) |
| ABSTRACT | The present invention provides isolated FAD2, FAD3, FAB1 and FAE1 genes and FAD2, FAD3, FAB1 and FAE1 protein sequences of Camelina species, e.g., Camelina sativa, mutations in Camelina FAD2, FAD3, FAB1 and FAE1 genes, and methods of using the same. In addition, methods of altering Camelina seed composition and/or improving Camelina seed oil quality are disclosed. Furthermore, methods of breeding Camelina cultivars to produce plants having altered or improved seed oil and/or meal quality are provided. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/770466 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/1029 (20130101) C12N 15/8247 (20130101) Original (OR) Class Enzymes C12Y 114/19003 (20130101) C12Y 203/01179 (20130101) C12Y 203/01199 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230233340 | PELZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua PELZ (San Diego, California); Luca DE VIVO (San Diego, California); Falko KUESTER (La Jolla, California); Herbert BARRACK (La Mesa, California) |
| ABSTRACT | A unibody transtibial prosthetic device includes a socket personalized for a specific patient's residual limb. A pylon extends from the socket, the pylon being a unitary polymer structure of interconnected elongated supports having open spaces therebetween. The device also includes a foot-ankle complex, the foot-ankle complex being a unitary polymer extending from the pylon, the foot and ankle unitary structure being shaped to provide multi-axial dynamic flex to enable dorsiflexion, plantar flexion, inversion and eversion motion for smooth symmetric gait performance and energy capture and return. The socket, pylon and foot-ankle complex are portions of a unibody. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 18/009915 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) Original (OR) Class A61F 2/80 (20130101) A61F 2/5046 (20130101) A61F 2002/607 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230233343 | Pelz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Pelz (San Diego, California); Luca De Vivo (San Diego, California); Falko Kuester (La Jolla, California); Herbert J. Barrack (La Mesa, California) |
| ABSTRACT | A unibody transtibial prosthetic device includes a socket personalized for a specific patient’s residual limb. A pylon extends from the socket, the pylon being a unitary polymer structure of interconnected elongated supports having open spaces therebetween. The device also includes a foot-ankle complex, the foot-ankle complex being a unitary polymer extending from the pylon, the foot and ankle unitary structure being shaped to provide multi-axial dynamic flex to enable dorsiflexion, plantar flexion, inversion and eversion motion for smooth symmetric gait performance and energy capture and return. The socket, pylon and foot-ankle complex are portions of a unibody. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/185011 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/80 (20130101) Original (OR) Class A61F 2/5046 (20130101) A61F 2/6607 (20130101) A61F 2002/505 (20130101) A61F 2002/607 (20130101) A61F 2002/6621 (20130101) A61F 2002/6642 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230237698 | Villalpando et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Carlos Young Villalpando (Altadena, California); Ashot Hambardzumyan (Porter Ranch, California) |
| ABSTRACT | A system provides descriptor-based feature matching during terrain relative navigation (TRN). A scale and orientation (SO) module acquires a source image, image and slope pixel windows, and ring mask. The SO module combines corresponding pixels from the image pixel window and the slope pixel window to generate intermediate values, accumulates the intermediate values into ring accumulators, sums the accumulated values to generate a final ring value, and determines an orientation stability measure, and final scale and orientation values. An extract descriptors (ED) module acquires the source image, the image and slope pixel windows, final scale and orientation values, sector values, and a rink mask value. The ED module identifies pixels of interest, reorients the sector values. combines corresponding pixels from the image pixel window and the slope pixel window, accumulates and normalizes the intermediate values, and generates an image feature descriptor per coordinate. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/158721 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/005 (20130101) Image Data Processing or Generation, in General G06T 1/20 (20130101) G06T 7/13 (20170101) G06T 7/74 (20170101) Original (OR) Class G06T 2207/10032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20230234887 | Yaw |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Form Flex Compound (DBA and sole Proprietorship for Tammy Yam under the Laws of the State of Oregon) (springfield, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tammy Yaw (springfield, Oregon) |
| ABSTRACT | An air-dry clay moldable and workable for sculptural applications, comprising a formulation of: (1) caulk or caulk base material and (2) a thickening agent and/or a detackifier in sufficient proportions to form a clay that can air dry to a substantially solid form at room temperature. The clay may include both a thickening agent and detackifier. The caulk or caulk base material comprises by weight percent: 40-90%, or 50-80%, or 60-75% of the formulated clay. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/010933 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 24/08 (20130101) C04B 24/168 (20130101) C04B 26/10 (20130101) Original (OR) Class C04B 2103/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230233749 | Bruning et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Securisyn Medical, LLC (Littleton, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Bruning (Monument, Colorado); Greg Letendre (USAFA, Colorado); Arthur Kanowitz (Littleton, Colorado); Pierre Noel (Scottsdale, Arizona); Kelly McKay (Southern Pines, North Carolina); Patrick Parkinson (Denver, Colorado); Michael Brown (Thornton, Colorado); Dmitri Kyle (Denver, Colorado) |
| ABSTRACT | A chest drainage system securing apparatus for securing and maintaining chest drainage systems in position following placement into a human or animal patient and preventing movement or unplanned removal thereof in response to the application of significant forces in any direction thereto, be they longitudinal, torsional/rotational or bending. The securement system includes retention devices secured to a chest tube which interact with an adhesive pad releasably attached to a patient to ensure proper positioning of the chest tube. The adhesive pad includes one or more Heimlich-type valves for sealing sucking chest wounds and for sealing an incision formed in a patients skin and chest for the placement and insertion of a chest tube. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 18/011223 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/84 (20210501) Original (OR) Class A61M 25/0075 (20130101) A61M 2025/0078 (20130101) A61M 2025/0273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230235701 | O'Rorke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| INVENTOR(S) | Morgan O'Rorke (West Hartford, Connecticut); Todd Haugsjaahabink (Springfield, Massachusetts); Matej Rutar (Manchester, Connecticut); Ryan Susca (Windsor, Connecticut) |
| ABSTRACT | A fuel system can include a selection and shutoff valve (SSOV) configured to allow a primary flow having a primary flow pressure to pass therethrough in a first state such that the primary flow can travel to an output line. The SSOV can also be configured to shut off the primary flow in a second state to prevent the primary flow from travelling to the output line. In the second state, the SSOV can be configured to allow a secondary flow from a secondary flow source to pass therethrough such that the secondary flow can travel to the output line. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581506 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/22 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2240/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230236556 | KIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kevinlab Co. (Ansan-si, South Korea) |
| ASSIGNEE(S) | Kevinlab Co. (Ansan-si, South Korea) |
| INVENTOR(S) | KYUNG HAK KIM (Suwon-si, South Korea); SUNG HWAN CHOI (Seoul, South Korea) |
| ABSTRACT | A method of managing data is proposed. The method includes collecting information, wherein detection values respectively matched to time points successive in time series are continuously collected, dividing sections, wherein a reference section is set, and remaining time points is divided into a correction section, calculating an equation, wherein a time point of the reference section and a detection value matched thereto are respectively set as a reference time point and a reference value, performing correction, wherein correction values calculated according to a time interval are calculated, verifying accuracy, wherein whether a ratio of the time points of the correction section to the time points is less than or equal to a preset allowable ratio is checked, and storing the data, wherein the reference value, equation, detection values or correction values, and correspondingly matched time points are stored as the data for the reference section and correction section. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106869 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 27, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230727.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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