FedInvent™ Patent Applications
Application Details for Thursday, August 03, 2023
This page was updated on Thursday, August 03, 2023 at 02:24 PM GMT
Department of Health and Human Services (HHS)
| US 20230240390 | Jayaraman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sundaresan Jayaraman (Atlanta, Georgia); Sungmee Park (Atlanta, Georgia) |
| ABSTRACT | An exemplary respiratory-protective-device attachment supporting apparatus (also referred to as a hub or fastening hub) and method are disclosed that can be placed at the parietal region of a person's head and connected to the respiratory protective device via one or more straps. The attachment supporting apparatus provides a large surface area for the securing of the respiratory protective device to the face to enhance the fit and comfort of the respiratory protective device. The attachment supporting apparatus also facilitates the correct, rapid, and repeatable donning of the RPD to ensure the proper protection against inhalation hazards. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/162323 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/1153 (20130101) A41D 13/1161 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2207/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240539 | GEORGAKOUDI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); Lahey Clinic, Inc. (Burlington, Massachusetts) |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts); Lahey Clinic, Inc. (Burlington, Massachusetts) |
| INVENTOR(S) | Irene GEORGAKOUDI (Winchester, Massachusetts); Einstein GNANATHEEPAM (Medford, Massachusetts); Robert Michael TROUT (Medford, Massachusetts); Thomas SCHNELLDORFER (Arlington, Massachusetts) |
| ABSTRACT | Methods for improved imaging of internal tissue structures, such as lesions in the peritoneum, are disclosed employing color-weighted Polarization Enhanced Light (mPEL) imaging. A target tissue can be Illuminated with light of defined polarization at a plurality of wavelengths or wavelength bands. Scattered light from the tissue is collected and its polarization states analyzed and detected either via a polarization sensitive camera or a combination or polarizing filters and a standard camera. Light detected at distinct polarization states and colors is weighted by a factor and combined to yield an image that results in optimized visualization of lesions and/or discrimination of malignant from benign lesions. The factors may be identified based on a combination of Monte Carlo simulations and regression analysis to yield enhanced sensitivity to the tissue scattering power. Alternatively, the factors may be identified through machine learning based optimization algorithms to optimize tissue classification. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/101294 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) Original (OR) Class A61B 5/0084 (20130101) A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240553 | Halpern et al. |
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| FUNDED BY |
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| APPLICANT(S) | Howard J. Halpern (Chicago, Illinois); Boris Epel (Chicago, Illinois) |
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| INVENTOR(S) | Howard J. Halpern (Chicago, Illinois); Boris Epel (Chicago, Illinois) |
| ABSTRACT | An apparatus and method for improved S/N measurements useful for electron paramagnetic resonance imaging in situ and in vivo, using high-isolation transmit/receive surface coils and temporally spaced pulses of RF energy (e.g., in some embodiments, a RF pi pulse) having an amplitude sufficient to rotate the magnetization by 180 degrees followed after varied delays, by a second RF pulse having an amplitude half that of the initial pulse to rotate the magnetization by, e.g., 90 degrees (a pi/2 pulse), to the plane orthogonal to the static field where it evolves for a short time. Then a third RF pi pulse sufficient to rotate the magnetization by, e.g., 180 degrees, forms an echo (in some embodiments, the second and third pulses are from the same signal as the first pulse but are phase shifted by 0, 90, 180, or 270 degrees to reduce signal artifact), to image human body. |
| FILED | Tuesday, March 28, 2023 |
| APPL NO | 18/127538 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/60 (20130101) G01R 33/341 (20130101) G01R 33/3607 (20130101) G01R 33/3621 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240561 | Neely et al. |
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| FUNDED BY |
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| APPLICANT(S) | Father Flanagan's Boys' Home Doing Business as Boys Town National Research Hospital (Omaha, Nebraska) |
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| INVENTOR(S) | Stephen Taylor Neely (Omaha, Nebraska); Gabrielle Merchant (Omaha, Nebraska) |
| ABSTRACT | Estimating inner and middle ear pathologies and conditions, such as issues caused by effusion in the ear, from wideband acoustic immittance can be accomplished by use of an analog-electric model of an ear canal and inner ear. The model is utilized to convert acoustic measurements into output data. The output data can be used to train a machine learning network to identify classifiers that would indicate the presence of an issue in the ear, such as the presence and amount of effusion in the ear. The model is based upon ear mechanics and includes a number of inputs from the acoustic measurements that are fit and converted to the output data that can be compared to measured data for hearing loss to train a system to quickly and easily diagnose an estimated effusion volume or other condition, such as via a diagnostic tool. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160811 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/126 (20130101) Original (OR) Class A61B 5/7267 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240562 | Neely et al. |
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| FUNDED BY |
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| APPLICANT(S) | Father Flanagan's Boy's Home Doing Business as Boys Town National Research Hospital (Omaha, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Taylor Neely (Omaha, Nebraska); Gabrielle Merchant (Omaha, Nebraska) |
| ABSTRACT | Estimating conductive hearing loss from wideband acoustic immittance can be accomplished by use of an analog-electric model of an ear canal and inner ear utilized to convert acoustic measurements into output data. The output data can be used to create conductive hearing loss methods for diagnostically estimating hearing loss based upon the acoustic measurements. The model includes a number of inputs from the acoustic measurements that are fit and converted to the output data that can be compared to measured data for hearing loss to train a system to quickly and easily diagnose an estimated hearing loss, such as via a diagnostic tool. The system can also be trained to identify an ear type based upon the transformed acoustic measurement data, and the type of ear can be used to provide additional hearing loss estimation. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160827 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/126 (20130101) Original (OR) Class A61B 5/7267 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240585 | WEISS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Shennan WEISS (Philadelphia, Pennsylvania); Zachary WALDMAN (Philadelphia, Pennsylvania); Inkyung SONG (West Windsor, New Jersey) |
| ABSTRACT | A device and a signal processing method that can be used with a device to recognize and distinguish a physiological high-frequency oscillation (HFO) from a pathological high-frequency oscillation. The signal processing method detects a physiological HFO in the electrical brain signal one regimen of electrical or optogenetic brain stimulation can be triggered, alternatively if the method detects a pathological HFO associated with epilepsy a different regimen of electrical or optogenetic brain stimulation can be triggered. Thus, the signal processing method can be utilized in a closed loop brain stimulation device that serves the dual purpose of both enhancing memory encoding, consolidation, and recall, or improving cognition, and reducing the probability of a seizure in a patient with epilepsy. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/965975 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) A61B 5/291 (20210101) A61B 5/369 (20210101) A61B 5/374 (20210101) Original (OR) Class A61B 5/742 (20130101) A61B 5/4094 (20130101) A61B 5/4836 (20130101) A61B 5/7203 (20130101) A61B 5/7225 (20130101) A61B 5/7264 (20130101) A61B 5/7282 (20130101) Electric Digital Data Processing G06F 17/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240601 | Ahlers et al. |
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| FUNDED BY |
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| APPLICANT(S) | Naval Medical Research Center (Silver Spring, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the secretary of the Navy (Silver Spring, Maryland) |
| INVENTOR(S) | Stephen T. Ahlers (Olney, Maryland); Anna E. Tschiffely (Walkersville, Maryland) |
| ABSTRACT | This invention discloses a method for improving behavioral deficits and lowering brain Aβ42 in subjects at risk for or in early stage of Alzheimer's disease or other neurodegenerative diseases by exposing said subject to frequent repetitive low intensity blast overpressure. The invention also discloses a method for treating and preventing Alzheimer's disease or other neurodegenerative diseases and associated conditions by reduce abnormal accumulation of brain protein, improve brain inflammation and clearance of amyloid beta. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/105059 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4064 (20130101) A61B 5/4884 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240618 | Brunner et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Peter Brunner (St. Louis, Missouri); Tao Xie (St. Louis, Missouri); Jon Willie (St. Louis, Missouri); Eric Leuthardt (St. Louis, Missouri) |
| ABSTRACT | Computing systems and computer-implemented methods for removing brain stimulation artifacts in neural signals are disclosed. The method makes use of a matching pursuit algorithm to accurately extract the stimulation artifact. The disclosed method removes the stimulation artifact associated with individual stimulation pulses without needing additional information from previous stimulation pulses or other electrodes. The disclosed method is compatible for use with various stimulation frequencies, does not need any filtering, and can recover neural signals almost immediately after stimulation. The disclosed method is compatible for use in has great potential in closed-loop systems used in various neurological diagnostic and therapeutic procedures. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/163257 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/372 (20210101) A61B 5/7217 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240637 | Bradford et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNA (Oakland, California) |
| INVENTOR(S) | David S. Bradford (Sausalito, California); Jeffrey C. Lotz (San Mateo, California) |
| ABSTRACT | Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission. The labeled pain factors allow spatial differentiation in the imaging sufficient to specify the location of the pain so as to drive therapeutic decisions and techniques in order to treat the pain. Pain factors labeled and imaged in this manner may include one or more of nerve factors, blood vessel factors, cellular factors, and inflammation factors. Labeled markers may include for example radioactive materials (e.g. tritiated or iodinated molecules) or other materials such as metal (e.g. gold) nanoparticles. Intermediary binding materials may be used, such as for example bi-specific antibodies. Therapeutic components of the system and method include for example localized energy delivery or ablation treatments, or local drug or other chemical delivery. Locations containing pain factor selectively bound by targeted agents are selectively treated with directed energy into a region containing the targeted agent bound to the pain factor. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/955149 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4041 (20130101) A61B 5/4824 (20130101) A61B 6/506 (20130101) Original (OR) Class A61B 18/14 (20130101) A61B 2018/00339 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 51/1096 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/007 (20130101) A61M 5/1723 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240641 | ELHILALI et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Mounya ELHILALI (North Potomac, Maryland); Annapurna KALA (Baltimore, Maryland) |
| ABSTRACT | A computer-implemented method, a computer system, and a non-transitory computer readable medium are provided that perform a method for determining an auscultation quality metric (AQM). The computer-implemented method includes obtaining an acoustic signal representative of pulmonary sounds from a patient; determining a plurality of derived signals from the acoustic signal; performing a regression analysis on the plurality of derived signals; and determining the AQM from the regression analysis. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 18/004966 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7221 (20130101) A61B 7/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240649 | Fatemi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mostafa Fatemi (Rochester, Minnesota); Azra Alizad (Rochester, Minnesota); Marek Belohlavek (Scottsdale, Arizona); Viksit Kumar (Rochester, Minnesota) |
| ABSTRACT | Described here are systems and method for using ultrasound to localize a medical device to which an active ultrasound element that can transmits ultrasound energy is attached. Doppler signal data of the medical device are acquired while the active element is transmitting acoustic energy, and the Doppler signal data are processed to detect symmetric Doppler shifts associated with the active element. The systems and methods described in the present disclosure enable tracking and display of one or more locations on or associated with the medical device. |
| FILED | Wednesday, March 22, 2023 |
| APPL NO | 18/188308 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/488 (20130101) A61B 8/0841 (20130101) A61B 8/4245 (20130101) Original (OR) Class A61B 8/4488 (20130101) A61B 90/37 (20160201) A61B 2034/2063 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240768 | Hendrick et al. |
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| FUNDED BY |
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| APPLICANT(S) | Virtuoso Surgical, Inc. (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Hendrick (Nashville, Tennessee); Neal Dillon (Nashville, Tennessee); Evan Blum (Nashville, Tennessee) |
| ABSTRACT | An insertable robot for minimally invasive surgery includes a tube array having a guide tube housed within a straightening tube. The guide tube includes a curved working end. The guide tube may be axially translated and rotated relative to the straightening tube such that the curved working end is constrained inside the straightening tube, causing the curved working end to achieve a smaller dimension. The tube array is inserted into a working channel on an endoscope, resectoscope or trocar. Once the tube array is inserted, the curved working end of the guide tube is translated forward beyond the distal end of the working channel, allowing the curved working end to return to its pre-formed shape. A surgical tool is inserted through the guide tube for an operation. The straightening tube allows the guide tube curved working end to be temporarily straightened during insertion and removal of the tube array. |
| FILED | Tuesday, April 04, 2023 |
| APPL NO | 18/130844 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/018 (20130101) A61B 1/00133 (20130101) A61B 34/30 (20160201) Original (OR) Class A61B 2017/0034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240769 | Hendrick et al. |
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| FUNDED BY |
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| APPLICANT(S) | Virtuoso Surgical, Inc. (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Hendrick (Nashville, Tennessee); Neal Dillon (Nashville, Tennessee); Evan Blum (Nashville, Tennessee) |
| ABSTRACT | An insertable robot for minimally invasive surgery includes a tube array having a guide tube housed within a straightening tube. The guide tube includes a curved working end. The guide tube may be axially translated and rotated relative to the straightening tube such that the curved working end is constrained inside the straightening tube, causing the curved working end to achieve a smaller dimension. The tube array is inserted into a working channel on an endoscope, resectoscope or trocar. Once the tube array is inserted, the curved working end of the guide tube is translated forward beyond the distal end of the working channel, allowing the curved working end to return to its pre-formed shape. A surgical tool is inserted through the guide tube for an operation. The straightening tube allows the guide tube curved working end to be temporarily straightened during insertion and removal of the tube array. |
| FILED | Tuesday, April 04, 2023 |
| APPL NO | 18/130855 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/018 (20130101) A61B 1/00133 (20130101) A61B 34/30 (20160201) Original (OR) Class A61B 2017/0034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240935 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Chen Yang (Newton, Massachusetts); Ji-Xin Cheng (Newton, Massachusetts) |
| ABSTRACT | An example photoacoustic system for neurostimulation includes a light producing device for producing light of a specific wavelength. At least one nanotransducer is binded on a surface of a neuron. The nanotransducer converts the light with the specific wavelength into at least one acoustic wave at or near the neuron. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103093 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 23/00 (20130101) Original (OR) Class A61H 2201/10 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0603 (20130101) A61N 2005/063 (20130101) A61N 2005/0659 (20130101) A61N 2005/0663 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240981 | Gu et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Zhen Gu (Los Angeles, California); Zejun Wang (Los Angeles, California) |
| ABSTRACT | A therapeutic hybrid microneedle patch mimics the inherent counter-regulatory effects of β-cells and α-cells for blood glucose management by dynamically releasing insulin or glucagon contained within the microneedles of the therapeutic hybrid microneedle patch. The two types of microneedles in the therapeutic hybrid microneedle patch share a co-polymerized matrix but comprise different ratios of the key monomers to be ‘dually-responsive’ to both hyper- and hypoglycemic glucose conditions. In a type 1 diabetic mouse model, the therapeutic hybrid microneedle patch effectively controls hyperglycemia while minimizing the occurrence of hypoglycemia in the setting of insulin therapy and simulated delayed meal or insulin overdose. In other embodiments, multiple patches are applied to achieve similar results. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 18/010807 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) Original (OR) Class A61K 38/26 (20130101) A61K 38/28 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) A61M 2037/0023 (20130101) A61M 2037/0046 (20130101) A61M 2037/0053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241000 | Nel et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andre E. Nel (Sherman Oaks, California); Huan Meng (Los Angeles, California); Sean Allen (Culver City, California) |
| ABSTRACT | In various embodiments nanoparticle drug delivery vehicles are provided herein for the effective delivery of a GSK3 inhibitor. In certain embodiments the drug delivery vehicle comprises a nanoparticle comprising one or more cavities disposed within the nanoparticle and an outside surface where the one or more cavities are in fluid communication the outside surface of the nanoparticle; a GSK3 inhibitor disposed within said one or more cavities; and a lipid bilayer disposed on the surface of said nanoparticle where said lipid bilayer fully encapsulates said nanoparticle. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 18/013508 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 31/55 (20130101) A61K 31/136 (20130101) A61K 31/497 (20130101) A61K 31/704 (20130101) A61K 31/4745 (20130101) A61K 31/5377 (20130101) A61K 31/5517 (20130101) A61K 31/7068 (20130101) A61K 47/24 (20130101) A61K 47/64 (20170801) A61K 47/6851 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 1/18 (20180101) A61P 11/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241001 | Mitchell et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Mitchell (Philadelphia, Pennsylvania); Pedro Guimaraes (Belo Horizonte, Brazil); Rui Zhang (Philadelphia, Pennsylvania); Roman Spektor (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions comprising a lipid nanoparticle (LNP) formulation comprising a LNP having encapsulated therein a barcoded mRNA (b-mRNA), and methods for using the same. Such methods include analyzing in vivo delivery of a composition. |
| FILED | Saturday, September 19, 2020 |
| APPL NO | 17/761274 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 31/7105 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241019 | Schopfer et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Francisco J. Schopfer (Pittsburgh, Pennsylvania); Bruce A. Freeman (Pittsburgh, Pennsylvania); Yang Zhao (Ann Arbor, Michigan); Yuqing E. Chen (Superior Township, Michigan); Jifeng Zhang (Ann Arbor, Michigan) |
| ABSTRACT | A method comprising administering to a subject having an aneurysm, suspected of having an aneurysm, or at risk of developing an aneurysm, a therapeutically effective amount of a compound selected from (i) a nitroalkene fatty acid, (ii) an unsaturated fatty acid having an electron withdrawing group, a leaving group, and a carbon-carbon double bond disposed between the electron withdrawing group and the leaving group, (iii) a thiolated nitro fatty acid, (iv) a dicarboxylic acid compound containing an electron withdrawing group, or a mixture of at least two of (i)-(iv). |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 18/009935 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/231 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241026 | NGO et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | John T. NGO (Cambridge, Massachusetts); Mary DUNLOP (Newton, Massachusetts); Elliot Parker TAGUE (Brookline, Massachusetts); Nathan Michael TAGUE (Brookline, Massachusetts); Alexander Michael MARZILLI (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to polypeptide systems using drug-controlled peptide docking domains and cognate docking domain-binding peptides and their use to control cellular signaling, activity, and/or gene expression. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/173277 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Original (OR) Class A61K 31/4965 (20130101) A61K 31/5377 (20130101) A61K 47/6425 (20170801) Peptides C07K 14/02 (20130101) C07K 14/47 (20130101) C07K 14/705 (20130101) C07K 14/43595 (20130101) C07K 2319/03 (20130101) C07K 2319/60 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241032 | Johnson |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bankole A. Johnson (Charlottesville, Virginia) |
| ABSTRACT | Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes. |
| FILED | Friday, February 03, 2023 |
| APPL NO | 18/164175 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4178 (20130101) Original (OR) Class A61K 31/7048 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6888 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/172 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241035 | Longaker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael T. Longaker (Atherton, California); Gerlinde Wernig (Woodside, California); Jeffrey A. Norton (Redwood City, California); Geoffrey Gurtner (Portola Valley, California); Michael Januszyk (Daly City, California); Deshka Foster (San Bruno, California); Malini Chinta (Redwood City, California) |
| ABSTRACT | Aspects of the present disclosure include methods of treating a subject to reduce adhesion formation. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 18/009637 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 41/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241043 | MEHRARA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Babak MEHRARA (Chappaqua, New York); Jason GARDENIER (Altona, New York); Ira SAVETSKY (Cedarhurst, New York); Omer ARAS (New York, New York) |
| ABSTRACT | Provided are pharmaceutical compositions and methods of treating or preventing edema, using an anti-T cell agent, an anti-TGF-β1 agent, or an anti-angiotensin agent, preferably a combination of at least two such agents. The pharmaceutical compositions can be formulated for systemic or local administration, and are preferably administered topically. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/102437 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) A61K 31/42 (20130101) A61K 31/277 (20130101) A61K 31/401 (20130101) A61K 31/436 (20130101) A61K 31/4412 (20130101) Original (OR) Class A61K 31/4418 (20130101) A61K 38/13 (20130101) A61K 45/06 (20130101) A61K 47/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241049 | Petrukhin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Konstantin Petrukhin (New Windsor, New York); Boglarka Racz (Brooklyn, New York); Andras Varadi (Brooklyn, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Konstantin Petrukhin (New Windsor, New York); Boglarka Racz (Brooklyn, New York); Andras Varadi (Brooklyn, New York) |
| ABSTRACT | The subject invention provides a method for treating a non-alcoholic fatty liver disease (NAFLD) disease in a subject afflicted therewith comprising administering to the subject a pharmaceutical composition comprising an amount of a compound which is a non-retinoid retinol-binding protein 4 (RBP4) antagonist effective to treat the subject, thereby treating the subject. The subject invention provides a method for treating gout in a subject afflicted therewith comprising administering to the subject a pharmaceutical composition comprising an amount of a compound which is a retinol-binding protein 4 (RBP4) antagonist effective to treat the subject, thereby treating the subject. |
| FILED | Thursday, August 01, 2019 |
| APPL NO | 17/261851 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/4545 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 19/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241054 | Jenkins |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Elysium Therapeutics, Inc. (Akron, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas E. Jenkins (Half Moon Bay, California) |
| ABSTRACT | The invention provides compositions and methods for the treatment or prevention of pain. The invention provides constructs whereby hydrolysis of the construct by a specified gastrointestinal enzyme directly, or indirectly, releases an opioid when taken orally as prescribed. The gastrointestinal enzyme mediated release of opioid from constructs of the invention is designed to be attenuated in vivo via a saturation or inhibition mechanism when overdoses are ingested. The invention further provides constructs that are highly resistant to oral overdose, chemical tampering, and abuse via non-oral routes of administration. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884305 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) Original (OR) Class A61K 47/55 (20170801) A61K 47/61 (20170801) A61K 47/64 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241077 | Ansari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Aseem Ansari (Madison, Wisconsin); Graham Erwin (Indianapolis, Indiana); Matthew P. Grieshop (New Berlin, Wisconsin) |
| ABSTRACT | The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence. |
| FILED | Friday, March 17, 2023 |
| APPL NO | 18/185478 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/785 (20130101) A61K 31/4164 (20130101) A61K 31/5517 (20130101) Original (OR) Class A61K 47/55 (20170801) A61K 47/545 (20170801) Heterocyclic Compounds C07D 495/14 (20130101) C07D 513/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/08 (20130101) Compositions of Macromolecular Compounds C08L 77/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241084 | Ernst et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert K. Ernst (Silver Spring, Maryland); Erin M. Harberts (Phoenix, Maryland); Alison J. Scott (Silver Spring, Maryland) |
| ABSTRACT | The present invention provides a method of treating sepsis in a subject, comprising administering to the subject an effective amount of a compound of the formula wherein R1 and R2 may be H, OH, protonated phosphate, a phosphate salt, a sugar phosphonate, or a mono-, di- or poly-saccharide, R3 may be OH or a mono-, di- or poly-saccharide, R4, R5, R6 and R7 may be an alkyl or alkenyl chain of up to 13 carbons (for a chain of 16 carbons), and R8, R9, R10 and R11 may be H, OH, or an alkyl or alkenyl ester of up to 16 carbons, or a salt thereof. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/086290 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/7016 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 31/00 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 13/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241091 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Henry Ford Health System (Detroit, Michigan) |
| ASSIGNEE(S) | Henry Ford Health System (Detroit, Michigan) |
| INVENTOR(S) | Jieli CHEN (Troy, Michigan); Michael CHOPP (Southfield, Michigan) |
| ABSTRACT | Provided herein are methods for the prevention and treatment of cardiovascular diseases and disorders in a subject diagnosed as having suffered a cerebrovascular injury by administering agents that contain or induce the expression of microRNA-126. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/173980 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 31/7105 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241093 | Pajvani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Utpal Pajvani (Leonia, New Jersey); Jinku Kang (Fort Lee, New Jersey) |
| ABSTRACT | This invention relates to the treatment of fatty liver disease. More specifically, embodiments of the invention provide a pharmaceutical carrier and a compound that reduces adipsin activity in liver cells. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154728 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7125 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241094 | Machielse et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mandos LLC (West Hollywood, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bernardus Nicolaas Machielse (North Potomac, Maryland); Allan Darling (North Potomac, Maryland) |
| ABSTRACT | This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C. |
| FILED | Monday, April 03, 2023 |
| APPL NO | 18/130132 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 31/724 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241103 | Orentas et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lentigen Technology, Inc. (Gaithersburg, Maryland); The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rimas J. Orentas (Seattle, Washington); Dina Schneider (Potomac, Maryland); Boro Dropulic (Ellicott City, Maryland); Dimiter S. Dimitrov (Frederick, Maryland); Zhongyu Zhu (Frederick, Maryland) |
| ABSTRACT | Chimeric antigen receptors containing CD33 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/820724 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/39558 (20130101) A61K 48/0016 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 16/2803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241105 | Seumois et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Gregory SEUMOIS (La Jolla, California); La Jolla Institute for Immunology (La Jolla, California) |
| ASSIGNEE(S) | La Jolla Institute for Immunology (La Jolla, California) |
| INVENTOR(S) | Gregory Seumois (La Jolla, California); Pandurangan Vijayanand (La Jolla, California) |
| ABSTRACT | Disclosed herein are methods of detecting an antigen-specific T cell (e.g., a HDM-reactive T cell) expressing IL-9 which contribute to a worsening of an allergy (e.g., a HDM-induced allergy) or detecting an antigen-specific T cell (e.g., a HDM-reactive T cell) associated with a positive prognosis. In some embodiments, also disclosed herein is a method of treating an allergy (e.g., a HDM-induced allergy) in a subject in need thereof based on the presence or absence of an antigen-specific T cell (e.g., a HDM-reactive T cell) that express IL-9. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 18/008633 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) A61P 37/08 (20180101) Peptides C07K 14/70575 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241121 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ke Cheng (Raleigh, North Carolina); Shiqi Hu (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods relating to the use of exosomes derived from human dermal papilla (DP) cells. In particular, the present disclosure provides novel compositions and methods for generating and maintaining exosomes derived from DP spheroids, as well as compositions and methods for delivering exosomes to a subject for various therapeutic purposes, such as the treatment of diseases and conditions related to hair follicle development. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/995066 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/36 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0628 (20130101) C12N 15/113 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241144 | HANAWA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE KITASATO INSTITUTE (Minato-ku, Japan); JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (Kawasaki-shi, Japan); Matsuyama University (Matsuyama-shi, Japan); TOKIWA PHYTOCHEMICAL CO., LTD. (Sakura-shi, Japan); TSUMURA & CO. (Minato-ku, Japan) |
| ASSIGNEE(S) | THE KITASATO INSTITUTE (Minato-ku, Japan); JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (Kawasaki-shi, Japan); Matsuyama University (Matsuyama-shi, Japan); TOKIWA PHYTOCHEMICAL CO., LTD. (Sakura-shi, Japan); TSUMURA & CO. (Minato-ku, Japan) |
| INVENTOR(S) | Toshihiko HANAWA (Tokyo, Japan); Sumiko HYUGA (Tokyo, Japan); Hiroshi ODAGUCHI (Tokyo, Japan); Yukihiro GODA (Kawasaki, Japan); Masashi HYUGA (Kawasaki, Japan); Masashi UEMA (Kawasaki, Japan); Hiroshi ASAKURA (Kawasaki, Japan); Nahoko UCHIYAMA (Kawasaki, Japan); Yoshiaki AMAKURA (Ehime, Japan); Morio YOSHIMURA (Ehime, Japan); Jinwei YANG (Chiba, Japan); Kazushige MIZOGUCHI (lbaraki, Japan) |
| ABSTRACT | Pharmaceutical preparations, Chinese herbal preparations, foods, and other compositions may contain, as an active ingredient, an ephedra extract, an ephedrine-alkaloid-free ephedra extract, or a polymercondensed tannin derived from an ephedra extract. Such compositions may be useful for preventing or treating COVID-19 infection (COVID-19). Such compositions are preferably provided in an orally ingestible form. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 18/000019 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/352 (20130101) A61K 36/13 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241162 | FELDMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University of the Commonwealth System of Higher Education (Philadelphia, Pennsylvania); Loyola University of Chicago (Maywood, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur M. FELDMAN (Wynnewood, Pennsylvania); Jonathan KIRK (Maywood, Illinois) |
| ABSTRACT | Bag3 is a multifunctional protein expressed predominantly in the heart, the skeletal muscle, the central nervous system and in many cancers. Although BAG3 was cloned only a decade ago, studies have shown that genetic variants, particularly those that result in haplo-insufficiency, can lead to severe left ventricular dysfunction; however, the full mechanisms responsible have remained obscure. To obviate the influence of heart failure itself on the biology of Bag3, ransgenic mice harboring a single allele knock-out were studied between 8 and 10 weeks of age before any obvious signs of heart failure were evident. The results were surprising and informative. First, it was found that despite a normal phenotype, young Bag3+/− had marked changes in the proteome that were characterized by changes in proteins associated with metabolism and apoptosis. Consistent with this finding, a decrease in the levels of critical proteins charged with maintaining the mitochondrial membrane potential was observed. It was also found that young mice shifted from a balance between the extrinsic and intrinsic pathways of apoptosis. However, in the presence of stress and the absence of Bag3 there was a shift from a balanced to an extrinsic dominant system (cleaved caspase 8). The diverse array of critical pathways regulated by Bag3 suggests a more important role especially during stress and that this role might include serving as an intracellular glue that holds proteins where they can be most effective rather than having them meet accidentally. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971477 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 48/0058 (20130101) A61K 48/0066 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241166 | Feng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Guoping Feng (Cambridge, Massachusetts); Xin Gong (Cambridge, Massachusetts); Jonathan Ting (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions and methods for minimally invasive optogenetic stimulation. More particularly, the present disclosure provides compositions and methods for using an ultra-sensitive step-function opsin for minimally invasive optogenetic stimulation. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/997306 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0622 (20130101) Peptides C07K 14/723 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15041 (20130101) C12N 2750/14141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241167 | Hoffman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanley Hoffman (Charleston, South Carolina); Dhandapani Kuppswamy (Mount Pleasant, South Carolina); Elena Tourkina (Portland, Oregon) |
| ABSTRACT | Disclosed are CSD domain peptides and methods of use to treat diseases and disorders including fibrosis, diseases or disorders involving microvascular leakage, kidney disease, heart disease, and age-related diseases or disorders. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 18/002951 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 13/12 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241173 | Isakson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Brant E. Isakson (Charlottesville, Virginia) |
| ABSTRACT | Inflammatory cell recruitment to local sites of tissue injury and/or infection is controlled by many signaling processes influencing cell-to-cell interactions between vascular endothelial cells (EC) in post-capillary venules and circulating leukocytes. Here we report that the ATP-release channel Pannexin1 (Panx1) opens downstream of EC activation by tumor necrosis factor α (TNFα). This process involves activation of Type 1 TNF receptors, recruitment of Src Family Kinases (SFK), and SFK-dependent phosphorylation of Panx1. We report a previously unidentified role for Panx1 channels in promoting leukocyte adhesion and emigration through the venous wall during acute systemic inflammation. The present application further discloses that Panx IL2 peptide consisting of amino acid sequence KYPIVEQYLKYGRKKQRR (SEQ ID NO:3) or 10Panx1 peptide consisting of amino acid sequence WRQAAFVDSY (SEQ ID NO:8) are inhibitors of leukocyte adhesion. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745495 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 38/2013 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) A61P 29/00 (20180101) Peptides C07K 14/435 (20130101) C07K 2319/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5064 (20130101) G01N 2800/328 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241186 | Daniell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); Johnson and Johnson Consumer Inc. (Skillman, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Henry Daniell (Media, Pennsylvania); Hyun Koo (Philadelphia, Pennsylvania); Robert J. Gambogi (Skillman, New Jersey); Anthony R. Geonnotti (Skillman, New Jersey); Latrisha K. Petersen (Skillman, New Jersey) |
| ABSTRACT | The invention provides a method for combating biofilm, said method comprising contacting a biofilm with a composition comprising effective amounts of one or more biofilm degrading enzymes in combination with antimicrobial agents or antimicrobial essential oils. The biofilm may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In a preferred aspect the invention provides a composition and method for use in the treatment or prevention of a biofilm infection in a subject, particularly in the oral cavity. |
| FILED | Monday, May 14, 2018 |
| APPL NO | 16/301000 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0058 (20130101) A61K 31/05 (20130101) A61K 31/045 (20130101) A61K 31/352 (20130101) A61K 31/618 (20130101) A61K 38/47 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241196 | Sikora et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc (Rockville, Maryland) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Aleksandra E. Sikora (Albany, Oregon); Ryszard A. Zielke (Corvallis, Oregon); Ann E. Jerse (Bethesda, Maryland) |
| ABSTRACT | Methods are disclosed for inducing an immune response to Neisseria gonorrhoeae in a mammalian subject. These methods include administering to the mammalian subject an effective amount of a MetQ protein and an effective amount of a K-type CpG oligodeoxynucleotide, thereby inducing the immune response. Also disclosed are immunogenic compositions including an effective amount of a MetQ protein and an effective amount of a K-type CpG oligodeoxynucleotide. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/790360 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/095 (20130101) Original (OR) Class A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241202 | Gambotto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea A. Gambotto (Pittsburgh, Pennsylvania); Louis Falo, Jr. (Wexford, Pennsylvania); Eun Kim (Allison Park, Pennsylvania) |
| ABSTRACT | A recombinant coronavirus vaccine is provided. Methods of making and delivering the coronavirus vaccine also are provided along with a method of generating and anti-coronavirus immune response. A microneedle array is provided, along with methods of making and using the microneedle array. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/927548 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 2319/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241232 | Stern et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, As Represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephan Timothy Stern (Bethesda, Maryland); David Michael Stevens (Bethesda, Maryland); Jay Arthur Berzofsky (Bethesda, Maryland); Julian Demond Burks (Bethesda, Maryland) |
| ABSTRACT | The present invention is directed to a polymer platform comprising poly(L-lysine succinylated) which specifically targets scavenger receptor A1. This platform may be used to conjugate different types of drugs to the polymer for treatment of specific diseases or conditions in a patient. The resulting conjugates display moderate stability or controlled drug release, and allows for delivery and release of drugs and other therapeutic moieties to tissues/cells that express scavenger receptor A1 in a controlled manner. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 18/009710 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/645 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241244 | Nel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andre E. Nel (Sherman Oaks, California); Huan Meng (Los Angeles, California); Kuo-Ching Mei (Los Angeles, California) |
| ABSTRACT | In certain embodiments a platform technology for the facilitating immune therapy in the treatment of cancer is provided. In certain embodiments nanocarriers are provided that facilitate delivery of an IDO inhibitor in conjunction with an inducer of cell death (ICD-inducer). In certain embodiments the IDO inhibitor is conjugated to a component of a lipid bilayer forming a nanovesicle. In still another embodiment, methods and compositions are provided where an ICD-inducing agent (e.g., doxorubicin, oxaliplatin, mitoxantrone etc.) and an IDO pathway inhibitor (e.g., an IDO inhibitor-prodrug) are integrated into a nanocarrier (e.g. a lipid-bilayer (LB)-coated nanoparticle), that allows systemic delivery to orthotopic pancreatic cancer site. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/823044 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/542 (20170801) A61K 47/544 (20170801) A61K 47/551 (20170801) A61K 47/554 (20170801) A61K 47/6905 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241245 | KENT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A&M University System (College Station, Texas); William Marsh Rice University (Houston, Texas); The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | The Texas A&M University System (College Station, Texas); William Marsh Rice University (Houston, Texas); The Trustees of Indiana University (Bloomington, Indiana) |
| INVENTOR(S) | Thomas A. KENT (Houston, Texas); Paul J. DERRY (Houston, Texas); David P. HUSTON (Houston, Texas); Anton V. LIOPO (Houston, Texas); James M. TOUR (Bellaire, Texas); Emily M. McHUGH (Houston, Texas); Kimberly MENDOZA (Houston, Texas); Kenneth R. OLSON (Berrien Springs, Michigan); Mansoor KAHN (Houston, Texas) |
| ABSTRACT | A therapeutic method for catalytically forming persulfide and/or polysulfide from hydrogen sulfide in vitro and in vivo using endogenously or exogenously released hydrogen sulfide is disclosed. That method comprises contacting cells in need including those under oxidative stress, traumatic brain injury (TBI) and hypoxia, or have an excess of hydrogen sulfide or deficiency of protein persulfidation with oxidized carbon nanoparticulate material in which the particles contain a plurality of carbonyl, hydroxyl and carboxyl substituents. Oxidized carbon nanoparticulate (OCN) material can be prepared from any of a variety of sources of which activated charcoal is preferred. A water-dispersible OCN material is described that does not need added hydrophilic polymers to provide dispersibility for at least 7 days at a concentration of about 1-5 mg/mL. These OCN materials also have a UV absorbance maximum in water of about 220 nm and pass through a 0.22 µm pore PES membrane. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 18/008837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 47/60 (20170801) A61K 47/6929 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241249 | OLSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Eric N. OLSON (University Park, Texas); Rhonda S. BASSEL-DUBY (Dallas, Texas); Benjamin R. NELSON (Dallas, Texas); Catherine A. MAKAREWICH (Dallas, Texas) |
| ABSTRACT | Disclosed are methods of treating a subject, such as those having or at risk of cardiomyopathies, with an effective amount of a recombinant adeno-associated virus (rAAV) virion, the rAAV virion comprising an AAV capsid and an expression cassette comprising a polynucleotide encoding a DWORF polypeptide operatively linked to a promoter. Compositions and kits relating to the same are also disclosed. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 18/004522 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0016 (20130101) A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241253 | YAZAKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Paul YAZAKI (Duarte, California); Jack SHIVELY (Duarte, California); Michael BOUVET (La Jolla, California); Jonathan DELONG (La Jolla, California); Yuman FONG (Duarte, California) |
| ABSTRACT | Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/160202 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 6/037 (20130101) A61B 6/4057 (20130101) A61B 34/20 (20160201) A61B 2034/2055 (20160201) A61B 2505/05 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 49/0032 (20130101) A61K 49/0058 (20130101) Original (OR) Class A61K 51/1048 (20130101) A61K 51/1057 (20130101) A61K 51/1063 (20130101) Peptides C07K 16/3007 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241256 | Sofou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stavroula Sofou (Baltimore, Maryland); Alaina Karen Howe (Baltimore, Maryland) |
| ABSTRACT | The disclosure is directed to method of inhibiting cancer cell growth by contacting cancer cells with a dose of an anti-cancer agent that is divided equally between a nanoparticle carrier encapsulating the anti-cancer agent and antibody carrier that binds to a cancer-specific receptor and is conjugated to the same anti-cancer agent. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 18/011071 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 51/0482 (20130101) Original (OR) Class A61K 51/1051 (20130101) A61K 51/1093 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2863 (20130101) C07K 16/3069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241293 | Taboas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Juan M. Taboas (Pittsburgh, Pennsylvania); Jingming Chen (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein are biomaterials, systems, and methods for guiding regeneration of an epiphyseal growth plate or similar interfacial tissue structures. In one aspect, the disclosed technology can include a biologic material that can comprise one or more of a hydrogel carrier for growth factors and MSCs, chondrogenic and immunomodulatory cytokines, microparticles for prolonged and spatially controlled growth factor delivery; and/or porous scaffold providing mechanical support. The implanted material can be applied via various different modalities depending on the nature of the physeal injury. One modality is an injectable hydrogel and another modality is an implantable hydrogel infused scaffold. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/167021 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/52 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/222 (20130101) A61L 27/3834 (20130101) A61L 27/3852 (20130101) A61L 2300/45 (20130101) A61L 2300/414 (20130101) A61L 2400/06 (20130101) A61L 2430/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241328 | Koska et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Koska Family Limited (East Sussex, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc Koska (Eastbourne, United Kingdom); Max Hannon (Flemingate, United Kingdom) |
| ABSTRACT | A pre-filled medical delivery system can have a blow-fill-seal (BFS) module and a mixing assembly. The BFS module can have first and second chambers, first and second sealed ports, and first and second actuation members. Each chamber can have a respective liquid agent therein. Each sealed port and each actuation member can be in fluid communication with a respective one of the chambers. The mixing assembly can be constructed for coupling to the BFS module. When coupled to the BFS module, the mixing assembly can breach the seals of the first and second ports and provide fluid communication therebetween. The disclosed systems, when assembled, can combine the liquid agents from the first and second chambers of the BFS component and deliver the combination as a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) to a patient. |
| FILED | Wednesday, March 08, 2023 |
| APPL NO | 18/119114 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/34 (20130101) Original (OR) Class A61M 5/3245 (20130101) A61M 2005/3252 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241385 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wen Li (Tallahassee, Florida); Kevin Clancy (Tallahassee, Florida) |
| ABSTRACT | Methods are provided for treating disorders associated with default mode network (DMN) dysfunction in a patient, where the methods include administering alpha-frequency transcranial alternating current stimulation (α-tACS) to the brain of the patient via at least one electrode, and where the α-tACS is effective to regulate DMN dysfunction and treat disorders associated therewith. Diseases and disorders associated with DMN dysfunction include normal or abnormal aging, cognitive impairment, or neuropsychiatric disorders such as Alzheimer's disease, schizophrenia, autism, or posttraumatic stress disorder (PTSD). |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103190 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36025 (20130101) Original (OR) Class A61N 1/36034 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241603 | Straus |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | First Light Diagnostics, Inc. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Don Straus (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure provides cartridges that are pre-loaded with reagents for performing antimicrobial susceptibility testing (AST) and FISH testing. Cartridges of the disclosure include various incubation wells loaded with different antimicrobial agents for differential growth analysis. Imaging wells with species-specific microbial probes, fluorescent tags, magnetic particles and dye-cushion layers allow for tagging and imaging of target microbes for differential growth analysis. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282623 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502761 (20130101) B01L 2200/16 (20130101) B01L 2200/021 (20130101) B01L 2200/0647 (20130101) B01L 2300/18 (20130101) B01L 2300/0864 (20130101) B01L 2400/043 (20130101) B01L 2400/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242330 | Forouzandeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Farzad Forouzandeh (Rochester, New York); David Borkholder (Canandaigua, New York); Robert Frisina (Tampa, Florida); Joseph Walton (Tampa, Florida); Xiaoxia Zhu (Tampa, Florida) |
| ABSTRACT | A miniature pump including a first chamber, a second chamber, a deformable membrane provided within the second chamber that divides the second chamber into first and second sub-chambers, the second sub-chamber defining a reservoir configured to contain liquid to be dispensed, a passage that connects the first chamber to the first sub-chamber, and an outlet in fluid communication with the reservoir, wherein pressurized fluid within the first internal chamber flows through the passage and into the first sub-chamber to compress the deformable membrane and cause liquid contained within the reservoir to flow out from the reservoir through the outlet and wherein the deformable membrane does not generate significant restoring forces when it is deformed and, therefore, will not return to its initial undeformed shape unless the reservoir is refilled. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/121511 |
| CURRENT CPC | Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 83/14 (20130101) Original (OR) Class Positive-displacement Machines for Liquids; Pumps F04B 43/06 (20130101) F04B 43/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242482 | Luesch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Smithsonian Institution (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Smithsonian Institution (Washington, District of Columbia) |
| INVENTOR(S) | Hendrik Luesch (Gainesville, Florida); Xiao Liang (Gainesville, Florida); Susan Matthew (Houston, Texas); Jason C. Kwan (Gainesville, Florida); Qi-Yin Chen (Gainesville, Florida); Valerie J. Paul (Fort Pierce, Florida) |
| ABSTRACT | The invention is directed towards compounds (e.g., Formulae (I)-(IX)), their mechanism of action, processes to prepare the compounds, methods of activating quorum sensing signaling activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formulae (I)-(IX)). |
| FILED | Friday, July 24, 2020 |
| APPL NO | 17/630138 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242488 | Roden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Richard B.S. Roden (Baltimore, Maryland); Ravi K. Anchoori (Baltimore, Maryland) |
| ABSTRACT | The invention of the instant application discloses spirocyclic guanidine compounds of general formula (I), shown below, and their use in methods of treating cancer |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/925923 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 221/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242534 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Tinghu Zhang (Brookline, Massachusetts); Nicholas Paul Kwiatkowski (Brookline, Massachusetts); Nathanael S. Gray (Stanford, California); Zhixiang He (Brookline, Massachusetts); Yanke Liang (Belmont, Massachusetts) |
| ABSTRACT | The present disclosure provides compounds of Formula (I), (II-1), (II-2), (II-3), or (II-4). The compounds of the present disclosure may be inhibitors of kinases (e.g., a cyclin-dependent kinase (CDK) (e.g., CDK7)). In some embodiments, the compounds disclosed herein are selective for inhibiting the activity of a kinase (e.g., CDK7) over certain other kinases (e.g., CDK2, CDK9, CDK12). In certain embodiments, the compounds do not bind or inhibit a 5-hydroxytryptamine (5-HT) receptor. Also provided are pharmaceutical compositions, kits, methods of use, and uses that involve the compounds disclosed herein. In some embodiments, the compounds are useful in inhibiting the activity of a kinase, inhibiting the growth of a cell, inducing apoptosis of a cell, treating a disease, and/or preventing a disease (e.g., proliferative disease, cystic fibrosis). |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/628794 |
| CURRENT CPC | Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242540 | GITAI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zemer GITAI (Princeton, New Jersey); Hahn KIM (Princeton, New Jersey); James K. MARTIN (Princeton, New Jersey); Joseph P. SHEEHAN (Princeton, New Jersey); Joshua D. RABINOWITZ (Princeton, New Jersey); Xincheng XU (Princeton, New Jersey); Connor CHAIN (Princeton, New Jersey) |
| ABSTRACT | In one aspect, compounds and associated pharmaceutical compositions are described herein for the treatment of cancer. In some embodiments, for example, a pharmaceutical composition comprises a compound of Formula (I) in an amount sufficient to exhibit anti cancer activity. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 18/013302 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242587 | Appella et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Daniel H. Appella (Rockville, Maryland); Hongchao Zheng (Bethesda, Maryland); Harsha C. Amarasekara (Rockville, Maryland); Victor Clausse (Bethesda, Maryland); George A. Kubi (Rockville, Maryland) |
| ABSTRACT | Disclosed are thyclotides, which are oligomers, each comprising (a) from about 8 to about 25 monomer units of formula (I) and (b) from 0 to about 24 monomer units of formula (II): wherein B is a nucleobase, which can be the same or different at each occurrence, or a pharmaceutically acceptable salt thereof. The thyclotides are soluble in water, bind strongly to complementary DNA and RNA, and are cell permeable. The thyclotides are useful as reagents for antisense and antigene applications, and as probes in molecular diagnostics and microarrays. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/918725 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/12 (20130101) Peptides C07K 14/003 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242589 | Su |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lishan Su (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention is directed to chimeric antigen receptor (CAR) compositions and methods of their use in cancer and anti-viral immunotherapy. In particular, the CAR of the invention comprises a costimulatory signal (CSS) domain comprising herpes virus entry mediator protein (HVEM) or a functional fragment or variant thereof. CARs comprising such a HVEM CSS exhibit enhanced effector function. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/605890 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464838 (20230501) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) A61P 31/18 (20180101) A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/7051 (20130101) C07K 14/70514 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/40 (20130101) C07K 16/1063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242593 | DOWD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium); THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium); THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| INVENTOR(S) | KIMBERLY DOWD (ROCKVILLE, Maryland); BARNEY S. GRAHAM (ROCKVILLE, Maryland); SUNG-YOUL KO (ROCKVILLE, Maryland); WING-PUI KONG (ROCKVILLE, Maryland); JOHN MASCOLA (ROCKVILLE, Maryland); THEODORE PIERSON (ROCKVILLE, Maryland); MAYURI SHARMA (CAMBRIDGE, Massachusetts); DONG YU (ROCKVILLE, Maryland) |
| ABSTRACT | Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946383 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/53 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242594 | MCLELLAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| INVENTOR(S) | Jason MCLELLAN (Austin, Texas); Jennifer MAYNARD (Austin, Texas); Andrea CHASSE (Austin, Texas); Ilya FINKELSTEIN (Austin, Texas); Mohammad JAVANMARDI (Austin, Texas); Jeffrey SCHAUB (Austin, Texas); Hung-Che KUO (Austin, Texas); Chia-Wei CHOU (Austin, Texas); Jory GOLDSMITH (Austin, Texas); Christy HJORTH (Diana, Texas); Ching-Lin HSIEH (Austin, Texas); Patrick BYRNE (Austin, Texas); Nicole JOHNSON (Austin, Texas); Nianshuang WANG (Austin, Texas); Daniel WRAPP (Chandler, Arizona) |
| ABSTRACT | Provided herein are engineered Coronavirus S proteins, such as engineered SARS-CoV-2 S proteins. In some aspects, the engineered S proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of engineered proteins as diagnostics, in screening platforms and/or in vaccine compositions. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 18/000112 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242612 | June et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl H. June (Merion Station, Pennsylvania); John Scholler (Narberth, Pennsylvania); Avery D. Posey, Jr. (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/170695 |
| CURRENT CPC | Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) Original (OR) Class C07K 14/70507 (20130101) C07K 16/30 (20130101) C07K 16/2803 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230242623 — COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF SARS-COV-2 VIRUS INFECTION
| US 20230242623 | FINN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia); THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (Bethesda,, Maryland) |
| ASSIGNEE(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia); THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (Bethesda,, Maryland) |
| INVENTOR(S) | M.G. FINN (Atlanta, Georgia); Asheley CHAPMAN (Atlanta, Georgia); Jason GOLDSTEIN (Atlanta, Georgia); Liangjun ZHAO (Atlanta, Georgia); Dennis Anthony BAGAROZZI, Jr. (Atlanta, Georgia); Asiya Seema CHIDA (Atlanta, Georgia) |
| ABSTRACT | Compositions that selectively bind to coronaviruses, including but not limited to SARS-COV-2 and methods of use thereof are provided. The disclosed antibodies and antigen-binding fragments were developed against SARS-CoV-2. The antibodies bind to the spike protein of coronaviruses. The disclosed antibodies are useful for diagnosing, detecting, preventing, and treating coronavirus infections. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 18/004534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242625 | KELLY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deborah F. KELLY (Lemont, Pennsylvania); Michael A. CASASANTA (State College, Pennsylvania); Mariah L. SCHROEN (Lemont, Pennsylvania); G.M. JONAID (State College, Pennsylvania) |
| ABSTRACT | Disclosed are novel targets for coronavirus therapies and methods of their use in screens for novel inhibitors of coronaviral infections. Also disclosed are novel coronavirus inhibitors that interact with said targets. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/009895 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) C07K 16/10 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/20023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242627 | Morris et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin V. Morris (Sierra Madre, California); Marc S. Weinberg (Encinitas, California); Tristan Scott (Pasadena, California); Daniel Lazar (San Diego, California) |
| ABSTRACT | Provided are compositions and methods for activating latent Human Immunodeciency Virus (HIV). The compositions and methods may utilize a recombinant peptide that has a DNA-binding zinc finger domain specific to the HIV LTR sequence. The recombinant peptide may also have a transcription factor (e.g. a transcription activator) that is conjuated to the zinc finger domain. Also provided are methods of treating HIV in a subject in need of the treatment. The method may involve activation of latent HIV in cells of the subject and selectively removing such cells from the subject, providing complete and effective treatment of HIV. |
| FILED | Tuesday, February 14, 2023 |
| APPL NO | 18/169127 |
| CURRENT CPC | Peptides C07K 14/00 (20130101) C07K 16/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242628 | Sajadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); U.S. Department of Veterans Affairs (Washington, District of Columbia); The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Sajadi (Cockeysville, Maryland); Paolo Lusso (Rockville, Maryland); Qingbo Liu (Rockville, Maryland) |
| ABSTRACT | The present invention provides broadly neutralizing and potent antibodies against HIV, compositions comprising the same and methods of use thereof. |
| FILED | Friday, November 27, 2020 |
| APPL NO | 17/778536 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1063 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242650 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GALAXY BIOTECH, LLC. (CUPERTINO, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyung Jin Kim (Cupertino, California); Wei-meng Zhao (Palo Alto, California); Hangil Park (San Francisco, California); Maximiliano Vasquez (Cupertino, California) |
| ABSTRACT | The present invention is directed toward a monoclonal antibody to fibroblast growth factor receptor 2, a pharmaceutical composition comprising same, and methods of treatment comprising administering such a pharmaceutical composition to a patient. |
| FILED | Friday, March 10, 2023 |
| APPL NO | 18/182242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/2863 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242666 | DOTTI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cell Medica, Inc. (Houston, Texas); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | Cell Medica, Inc. (Houston, Texas); The University of North Carolina Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Gianpietro DOTTI (Chapel Hill, North Carolina); Elisa LANDONI (Chapel Hill, North Carolina); Miriam DROSTE (Houston, Texas); Abdijapar SHAMSHIEV (Houston, Texas) |
| ABSTRACT | The present disclosure relates to methods and compositions related to Chimeric Antigen Receptors (“CARs”) and modifications to the framework sequences to eliminate tonic signaling. The compositions include modified binding members having a binding specificity to chondroitin sulfate proteoglycan 4 (CSPG4) and are stable when prepared as single chain antibody (scFv) and incorporated into CARs. The methods further include nucleic acid constructs for the expression of CSPG4 CARs, and the application of the CSPG4 CAR to therapeutic methods for the treatment of cancer. The present disclosure also relates to the modification of humanized framework sequences. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 18/003079 |
| CURRENT CPC | Peptides C07K 14/5418 (20130101) C07K 14/5434 (20130101) C07K 14/5443 (20130101) C07K 16/3053 (20130101) Original (OR) Class C07K 2317/565 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242871 | Sebastiano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanfor Junior University (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vittorio Sebastiano (Palo Alto, California); Kyle M. Loh (Palo Alto, California); Gugene Kang (Palo Alto, California) |
| ABSTRACT | Provided herein are, inter alia, compositions and methods for generating a population of PGCs with improved efficiencies and line-to-line consistency. Inductive signals are temporally dynamic: WNT activation for 12 hours incipiently differentiates primed hPSCs into posterior epiblast, while subsequently, sharp WNT inhibition together with BMP activation specifies PGCs. hPSC-derived PGCs can be easily purified by virtue of their CXCR4+PDGFRα-GARP-surface-marker profile. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 18/000072 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0611 (20130101) Original (OR) Class C12N 2501/11 (20130101) C12N 2501/15 (20130101) C12N 2501/125 (20130101) C12N 2501/155 (20130101) C12N 2501/235 (20130101) C12N 2501/415 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242900 | Adelman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zach N. Adelman (College Station, Texas); Kevin M. Myles (College Station, Texas); Sakiko Okumoto (College Station, Texas) |
| ABSTRACT | The current invention provides vector constructs that are pre-programmed to self-terminate or self-remove at a predetermined time and methods of making the same. The present invention further provides methods for creating organisms containing these vector constructs. Also provided are various transgenic organisms with the vector constructs, including plants, insects, and mammals. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 18/015753 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) Original (OR) Class C12N 15/8213 (20130101) C12N 15/8509 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242902 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Chang C. Liu (Irvine, California); Arjun Ravikumar (Washington, District of Columbia); Garri A. Arzumanyan (Irvine, California); Alex A. Javanpour (San Ramon, California) |
| ABSTRACT | The invention provides compositions comprising highly error-prone polymerases and methods of using the polymerases for rapid evolution of a nucleic acid sequence within host cells. The invention further provides a versatile synthetic biology platform for manipulating DNA replication inside a cell. The invention also provides a mutually orthogonal replication system for manipulating and tuning DNA replication of multiple nucleic acid molecules using the error-prone polymerases. |
| FILED | Friday, October 19, 2018 |
| APPL NO | 16/756813 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) C12N 15/1024 (20130101) C12N 15/1058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242903 | DAVE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Utpal DAVE (Nashville, Tennessee); Justin LAYER (Indianapolis, Indiana) |
| ABSTRACT | A system for multiplex expression of proteins in eukaryotic cells is provided wherein cells simultaneously expressing each of the proteins of the system in a cell can be selected and/or visualized. The system comprises a plurality of lentiviral based vectors that each allow for the expression of the protein of interest, and a fluorescent protein linked to a fusion peptide comprising a proteolytic cleavage site that itself is linked to an antibiotic resistance protein. Each of the vectors of the system has a separate and unique fluorescent protein encoding gene and/or a separate and unique antibiotic resistance gene. |
| FILED | Wednesday, September 18, 2019 |
| APPL NO | 17/276213 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/65 (20130101) C12N 15/86 (20130101) C12N 15/1058 (20130101) Original (OR) Class C12N 15/1065 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242912 | NAKANISHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kotaro NAKANISHI (Columbus, Ohio); Mi Seul PARK (New York, New York) |
| ABSTRACT | Disclosed herein are methods and compositions related to the use of the Argonaute-3 (AGO3) polypeptide in disease detection, prevention, and treatment. Specifically, disclosed herein are cleavage-inducing tiny RNAS (cityRNAs) which are capable of inducing AGO3 to slice nucleic acids. This powerful tool can be used in a variety of applications. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 18/011799 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2330/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242918 | SI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Longlong SI (Cambridge, Massachusetts); Haiqing BAI (Cambridge, Massachusetts); Donald E. INGBER (Cambridge, Massachusetts); Crystal Yuri OH (Cambridge, Massachusetts); Rachelle PRANTIL-BAUN (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are compositions and methods for inducing Type I interferon production. The compositions described comprise immunostimulatory oligonucleotide duplexes including a 5′ terminal monophosphate-CUGA-3′ (SEQ ID NO. 1) sequence. Compositions comprising the immunostimulatory oligonucleotide duplexes described can be used for the treatment of diseases or disorders that respond to interferons. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/926748 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 35/16 (20130101) A61K 39/39 (20130101) A61K 45/06 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242924 | Williams |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NATURE TECHNOLOGY CORPORATION (LINCOLN, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. Williams (Lincoln, Nebraska) |
| ABSTRACT | The present invention relates to the production and use of covalently closed circular (ccc) recombinant plasmids, and more particulary to vector modifications that improve express of said DNA molecules in the target organism. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067035 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 15/85 (20130101) C12N 15/635 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242938 | Asokan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); University of Florida Research Foundation, Incorporated (Gainsville, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravind Asokan (Chapel Hill, North Carolina); Patrick Havlik (Carrboro, North Carolina); Mavis Agbandje-McKenna (Gainesville, Florida); James K. Smith (Gainesville, Florida); Mario Mietzsch (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo. This disclosure also relates to recombinant adeno associated virus (rAAV) capsid proteins comprising one or more amino acid substitutions in the 5-fold region of the rAAV capsid that result in decreased reactivity to neutralizing antibodies, and their use as gene delivery vehicles. |
| FILED | Thursday, February 28, 2019 |
| APPL NO | 16/976408 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242961 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fina BioSolutions, LLC (Rockville, Maryland) |
| ASSIGNEE(S) | Fina BioSolutions, LLC (Rockville, Maryland) |
| INVENTOR(S) | Min-Ju Chang (Gaithersburg, Maryland); Natalia Oganesyan (North Potomac, Maryland); Andrew Lees (Silver Spring, Maryland) |
| ABSTRACT | The invention is directed to methods and compositions for the expression and purification of products such as peptides and proteins in microorganisms. In particular, pre-products are expressed recombinantly, wherein the cytoplasm of the microorganism alters the expressed pre-products to produce products in an active/final or otherwise desirable form. Alterations associated with expression of a desired recombinant product include shifting of the redox state of the cytoplasm to allow proper protein folding, site-directed cleavage of pre-proteins to activate the protein, site-directed cleavage of an unwanted methionine from the N terminus of the protein, and/or one or more ligations to form desired protein configurations, all within the same cell. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/797851 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) C12N 15/70 (20130101) C12N 2800/101 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 304/11018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242966 | Setliff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marion Francis Setliff (Nashville, Tennessee); Ivelin Stefanov Georgiev (Brentwood, Tennessee); Andrea Shiakolas (Nashville, Tennessee); Kelsey PILEWSKI (Nashville, Tennessee); Rohit VENKAT (Nashville, Tennessee) |
| ABSTRACT | The present disclosure relates to high-throughput systems and methods for the detection of ligand-blocking antibodies and for determining antibody potency. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/795104 |
| CURRENT CPC | Peptides C07K 16/1063 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/703 (20130101) C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242980 | Diehn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California); Jacob J. Chabon (Arvada, Colorado); David M. Kurtz (San Carlos, California) |
| ABSTRACT | Processes and materials to protect nucleic acid molecules are described. Processes and materials to detect neoplasms from a biopsy are described. Processes and materials to build a sequencing library are described. Cell-free nucleic acids can be sequenced and the sequencing result can be utilized to detect sequences derived from a neoplasm. |
| FILED | Wednesday, August 24, 2022 |
| APPL NO | 17/822028 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242989 | Dutta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anindya Dutta (Charlottesville, Virginia); Pankaj Kumar (Crozet, Virginia) |
| ABSTRACT | Provided are methods and kits for detecting an extrachromosomal circular DNA (eccDNA) in a biological sample. In some embodiments, the method comprises treating the biological sample to produce a tagged linearized fragment of genomic DNA; and determining whether the tagged linearized fragment is derived from an eccDNA to thereby detect the eccDNA. In some embodiments, the treating of the biological sample to produce a tagged linearized fragment of genomic DNA comprises treating the biological sample with an insertional enzyme complex to produce a tagged linearized fragment of genomic DNA. |
| FILED | Monday, April 13, 2020 |
| APPL NO | 17/603150 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243739 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Ji-Xin Cheng (Newton, Massachusetts); Lu Lan (Allston, Massachusetts); Jiaze Yin (Waltham, Massachusetts) |
| ABSTRACT | Systems and methods are provided for performing photothermal dynamic imaging. An exemplary method includes: scanning a sample to produce a plurality of raw photothermal dynamic signals; receiving the raw photothermal dynamic signals of the sample; generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise; and performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain. |
| FILED | Tuesday, March 28, 2023 |
| APPL NO | 18/127388 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/35 (20130101) G01N 21/47 (20130101) G01N 21/171 (20130101) Original (OR) Class G01N 2021/3595 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243765 | Ros et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alexandra Ros (Phoenix, Arizona); Daihyun Kim (Mesa, Arizona); Diandra Doppler (Scottsdale, Arizona); Jorvani Cruz Villarreal (Tempe, Arizona); Richard Kirian (Tempe, Arizona); Reza Nazari (Tempe, Arizona); Sahir Gandhi (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandra Ros (Phoenix, Arizona); Daihyun Kim (Mesa, Arizona); Diandra Doppler (Scottsdale, Arizona); Jorvani Cruz Villarreal (Tempe, Arizona); Richard Kirian (Tempe, Arizona); Reza Nazari (Tempe, Arizona); Sahir Gandhi (Tempe, Arizona) |
| ABSTRACT | A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel. The timing of sample droplets in the stream of fluid ejected through the nozzle is controlled by applying a triggering signal to electrodes positioned in the electrode chambers of the single-piece component. |
| FILED | Tuesday, April 04, 2023 |
| APPL NO | 18/295761 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0241 (20130101) B01L 3/502715 (20130101) B01L 2300/0645 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/201 (20130101) G01N 23/20025 (20130101) Original (OR) Class G01N 35/1016 (20130101) G01N 2035/1034 (20130101) G01N 2223/30 (20130101) G01N 2223/054 (20130101) G01N 2223/203 (20130101) G01N 2223/604 (20130101) G01N 2223/612 (20130101) G01N 2223/637 (20130101) G01N 2223/1016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230243773 — Power Transfer-Based Flexible Sensing System for Smart Hydrogel Swelling State Readout
| US 20230243773 | Reiche et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher F. Reiche (Salt Lake City, Utah); Julia Koerner (Hannover, Germany); Benozir Ahmed (Salt Lake City, Utah); Florian Solzbacher (Salt Lake City, Utah); Jules J. Magda (Salt Lake City, Utah) |
| ABSTRACT | A power transfer-based flexible sensing platform that can be used in a fluid environment includes at least one metallic thin film structure, with a polymeric encapsulation that protects the metallic thin film structure from the fluid environment, a smart hydrogel sandwiched between layers of the metallic thin film structure, the smart hydrogel being configured to swell or shrink in response to stimulus, and an AC power source or signal generator electrically connected to the at least one metallic film structure. The metallic thin film can include first and second U-shaped metallic thin film structures, each encapsulated, where the smart hydrogel is sandwiched between them. An AC power or signal source is electrically connected to one of the U-shaped structures, causing power to be inductively transferred to the other. Measurement of the induced power or other signal can be used to determine a concentration of an analyte in the fluid environment. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/161697 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14539 (20130101) A61B 5/14546 (20130101) A61B 2562/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/126 (20130101) G01N 27/227 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243807 | Lindsay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON behalf of ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart Lindsay (Phoenix, Arizona); Peiming Zhang (Gilbert, Arizona); Yanan Zhao (Tempe, Arizona) |
| ABSTRACT | A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178130 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3276 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243812 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gilyong Lee (Boston, Massachusetts); Sung-Jin Park (Johns Creek, Georgia); Kevin Kit Parker (Cambridge, Massachusetts); Andre G. Kleber (Boston, Massachusetts) |
| ABSTRACT | Engineered cardiac tissue structures and methods for forming the engineered cardiac tissue structures are provided herein. An example engineered cardiac tissue structure includes a support having a first side and a first engineered cardiac tissue layer disposed at the first side of the support. The first engineered cardiac tissue layer can include a geometrically insulated cardiac tissue node. Another example engineered cardiac tissue structure includes a support, a first engineered cardiac tissue layer, and a second engineered cardiac tissue layer. Excitation and contraction of the first engineered cardiac tissue layer bends the support and strains the second engineered cardiac tissue layer inducing excitation and contraction of the second engineered cardiac tissue layer. The excitation and contraction of the second engineered cardiac tissue layer bends the support and strains the first engineered cardiac tissue layer inducing excitation and contraction of the first engineered cardiac tissue layer thereby producing antagonistic cyclic contractions. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/096629 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5061 (20130101) G01N 33/5088 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243825 | Schneck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Schneck (Baltimore, Maryland); Hai-Quan Mao (Baltimore, Maryland); John Wirthlin Hickey (Baltimore, Maryland); Ariel Isser (Baltimore, Maryland) |
| ABSTRACT | Disclosed are methods for enriching and expanding antigen-specific T cells with paramagnetic nanoparticles comprising a major histocompatibility complex (MHC) or human leukocyte antigen (HLA) and a costimulatory molecule bound thereto. The platform eliminates the requirement of cell isolation and can be further adapted to be high throughput with the capability of processing multiple antigen-specific T cells in parallel. Accordingly, the disclosed methods provide a high-throughput workflow for the identification and analysis of antigen-specific T cell responses. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 18/011070 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54326 (20130101) G01N 33/56972 (20130101) Original (OR) Class G01N 2333/705 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243829 | LABAER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University (Scottsdale, Arizona); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua LABAER (Chandler, Arizona); Karen Sue ANDERSON (Chestnut Hill, Massachusetts); Garrick WALLSTROM (Mesa, Arizona); Sahar SIBANI (Revere, Massachusetts); Niroshan RAMACHANDRAN (San Marcos, California) |
| ABSTRACT | The present invention provides reagents and methods for breast cancer detection. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/173892 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 17/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) Enzymes C12Y 301/27004 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243905 | Gudino |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Natalia Gudino (Bethesda, Maryland) |
| ABSTRACT | An optically controlled, multi-transmitter magnetic resonance imaging system for multi-nuclear, high field applications is disclosed. In one embodiment, the MRI system may include a dual-tuned radio-frequency (RF), on-coil power amplifier for amplifying RF power signals at two or more frequencies for the multi-nuclear excitations for use in a dual-tuned coil MRI device or a nested coil MRI device. In one particular implementation, the dual-tuned amplifier of the MRI system may receive optical carrier signals through the broadband optical interface to control the on-coil amplifiers. A variable effective inductor circuit for use in tuning the dual-tuned amplifier is also disclosed. The variable effective inductor circuit includes a gallium nitride (eGaN) field effect transistor (FET) device connected to an inductor. The inductance of the variable effective inductor circuit can be adjusted by modulating a drain-source voltage of the eGaN FET device controlled based on a pulse duration of an optical carrier signal. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 18/013042 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3607 (20130101) G01R 33/3614 (20130101) Original (OR) Class G01R 33/3635 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245417 | Giger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maryellen Giger (Elmhurst, Illinois); Lindsay Douglas (Lee's Summit, Missouri); Deepa Sheth (Chicago, Illinois) |
| ABSTRACT | A method for electronically removing a lesion from a three-dimensional (3D) medical image includes segmenting each two-dimensional (2D) slice of a sequence of 2D slices of the 3D medical image to identify the lesion within any one or more of the 2D slices. The method includes deleting the lesion from each 2D slice in which the lesion was identified to create a sequence of lesion-deleted slices. The method includes constructing, based on the sequence of lesion-deleted slices, a lesion-deleted intensity-based projection image, such as a lesion-deleted maximum-intensity projection image. Advantageously, the method improves the accuracy of background parenchymal enhancement (BPE) by excluding high-intensity voxels that indicate the presence of a lesion, and thus are not indicative of BPE. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/161160 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/26 (20220101) Original (OR) Class G06V 10/82 (20220101) G06V 2201/03 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245716 | Joung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Luca Pinello (Jamaica Plain, Massachusetts); Jonathan Hsu (Cambridge, Massachusetts); Julian Grunewald (Charlestown, Massachusetts); Y. Esther Tak (Charlestown, Massachusetts); Md Nafiz Hamid (Quincy, Massachusetts) |
| ABSTRACT | Described herein are systems, methods, and compositions for the precise editing of DNA sequence(s) at specific loci to alter expression of target gene products at the pre-transcriptional or post-transcriptional level in a durable fashion, termed Stable and Heritable Alteration by Precision Editing (SHAPE). The SHAPE platform utilizes genetic modifiers (e.g., nucleases, (CRISPR guided) transposases, recombinases, base editors, and prime editors) to install specific sequence motifs at target sequences through precision genome engineering. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/928105 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/30 (20190201) Original (OR) Class G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230247376 | Lang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Massachusetts Eye and Ear Infirmary (Boston, Massachusetts); The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey H. Lang (Sudbury, Massachusetts); Aaron J. Yeiser (Allston, Massachusetts); Hideko Heidi Nakajima (Cambridge, Massachusetts); Ioannis Kymissis (New York, New York); Elizabeth Olson (New York, New York); Christopher I. McHugh (Boston, Massachusetts); Lukas Graf (Berlingen, Switzerland) |
| ABSTRACT | A piezoelectric sensor and amplifier for use with an auditory aid device are disclosed. The piezoelectric sensor includes a top sensor and a bottom sensor disposed on opposite surfaces of a flex printed circuit board. The top and bottom sensors are made of a piezoelectric material, such as PVDF. Further, the piezoelectric sensor is adapted to be implanted into a subject's ear, where the piezoelectric sensor is cantilevered with the free, or distal end, touching the umbo. The proximal end is held in place by a support that is affixed to the ear. Additionally, the piezoelectric sensor is shaped so that the width of the distal end is less than the width at the proximal end. Further, the piezoelectric sensor generates differential signals, which are then amplified using a differential amplifier circuit. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/104518 |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 17/00 (20130101) H04R 25/606 (20130101) Original (OR) Class H04R 25/609 (20190501) H04R 2225/57 (20190501) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/189 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230240601 | Ahlers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Medical Research Center (Silver Spring, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the secretary of the Navy (Silver Spring, Maryland) |
| INVENTOR(S) | Stephen T. Ahlers (Olney, Maryland); Anna E. Tschiffely (Walkersville, Maryland) |
| ABSTRACT | This invention discloses a method for improving behavioral deficits and lowering brain Aβ42 in subjects at risk for or in early stage of Alzheimer's disease or other neurodegenerative diseases by exposing said subject to frequent repetitive low intensity blast overpressure. The invention also discloses a method for treating and preventing Alzheimer's disease or other neurodegenerative diseases and associated conditions by reduce abnormal accumulation of brain protein, improve brain inflammation and clearance of amyloid beta. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/105059 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4064 (20130101) A61B 5/4884 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240625 | Maidment et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Real Time Tomography, LLC (Villanova, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew D.A. Maidment (Villanova, Pennsylvania); Brian Lee (Rockville, Maryland); Susan NG (Villanova, Pennsylvania); Peter A. Ringer (Allentown, Pennsylvania); Johnny Kuo (Lancaster, Pennsylvania); Raymond J. Acciavatti (Newtown Square, Pennsylvania) |
| ABSTRACT | A contrast-enhanced digital tomosynthesis system with a source configured to emit penetrating particles toward an source, a positioning apparatus configured to position the source relative to the object and the detector, and an imaging system coupled to the source, the detector, and the positioning apparatus. The imaging system is configured to control the positioning apparatus to position the source and detector relative to the object, control the source and the detector to acquire the series of projection images, and construct a tomographic volume capable of exhibiting super-resolution morphology and contrast-enhancement arising from injection of an exogenous contrast agent from data representing the acquired series of projection images or a subset thereof. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/061928 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/025 (20130101) Original (OR) Class A61B 6/54 (20130101) A61B 6/461 (20130101) A61B 6/481 (20130101) A61B 6/502 (20130101) A61B 6/505 (20130101) A61B 6/4452 (20130101) A61B 6/5235 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240668 | Harshman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean Harshman (Fairborn, Ohio); Anthony Qualley (Washington TWP, Ohio); Amanda Bowman (Miamisburg, Ohio); Kraig Strayer (Fairborn, Ohio); Rhonda Pitsch (Springfield, Ohio); Michael Brothers (Lebanon, Ohio) |
| ABSTRACT | Systems and methods for continuous real-time sweat sampling and analysis are disclosed. A sweat collection article and method of collecting sweat from a person's skin using the sweat collection article are provided. The sweat collection article includes: a sweat collecting tube placed adjacent to the person's skin, and at least one piece of flexible material that has an adhesive that adheres the article to the person's skin and is positioned to overlie one end of the tube. The second end of the sweat collecting tube is in fluid communication with an instrument such as a mass spectrometer that analyzes the sweat on a real-time basis. The systems and methods may further include a device for removing salt from the sweat that is arranged so that the sweat is transported to the device prior to being transported to the instrument for analyzing the sweat. |
| FILED | Saturday, April 01, 2023 |
| APPL NO | 18/194630 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/443 (20130101) A61B 5/4266 (20130101) A61B 5/6824 (20130101) A61B 5/6831 (20130101) A61B 10/0064 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241167 | Hoffman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanley Hoffman (Charleston, South Carolina); Dhandapani Kuppswamy (Mount Pleasant, South Carolina); Elena Tourkina (Portland, Oregon) |
| ABSTRACT | Disclosed are CSD domain peptides and methods of use to treat diseases and disorders including fibrosis, diseases or disorders involving microvascular leakage, kidney disease, heart disease, and age-related diseases or disorders. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 18/002951 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 13/12 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241196 | Sikora et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc (Rockville, Maryland) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Aleksandra E. Sikora (Albany, Oregon); Ryszard A. Zielke (Corvallis, Oregon); Ann E. Jerse (Bethesda, Maryland) |
| ABSTRACT | Methods are disclosed for inducing an immune response to Neisseria gonorrhoeae in a mammalian subject. These methods include administering to the mammalian subject an effective amount of a MetQ protein and an effective amount of a K-type CpG oligodeoxynucleotide, thereby inducing the immune response. Also disclosed are immunogenic compositions including an effective amount of a MetQ protein and an effective amount of a K-type CpG oligodeoxynucleotide. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/790360 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/095 (20130101) Original (OR) Class A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241237 | Dreaden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik Dreaden (Atlanta, Georgia); Priscilla Do (Atlanta, Georgia); Curtis James Henry (Atlanta, Georgia); Christopher Clayton Porter (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to methods for identifying molecular arrangements useful in managing diseases or conditions. In certain embodiments, this disclosure relates to treating an immune regulated disease comprising administering to a subject in need thereof an effective amount of a grouped molecular arrangement comprising a specific binding agent to CD19, a specific binding agent to CD3, and IL-12. In certain embodiments, this disclosure relates to screening test compounds comprising providing a library of multifunctional binding specificities and contacting the library with cells to evaluate in vitro therapeutic potential. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/919481 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6813 (20170801) A61K 47/6849 (20170801) Original (OR) Class A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241642 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); William R. Dichtel (Wilmette, Illinois); Nathan P. Bradshaw (Chicago, Illinois); Austin M. Evans (Evanston, Illinois) |
| ABSTRACT | Systems and methods for preparing covalent organic framework (COF) thin films is disclosed herein. The systems and method utilize COF colloidal inks, having a diameter of 10-1000 nm, expelled through a nozzle onto a substrate to prepare the COF thin film. The plurality of COF colloidal ink droplets have an effective deposition diameter from the nozzle onto a masked or unmasked substrate, where the substrate may be heated to an effective COF deposition temperature. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 18/001580 |
| CURRENT CPC | Apparatus for Applying Fluent Materials to Surfaces, in General B05C 5/0295 (20130101) B05C 11/11 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/26 (20130101) Original (OR) Class B05D 1/32 (20130101) B05D 3/0218 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241674 | Agarwal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida International University Board of Trustees (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arvind Agarwal (Miami, Florida); Cheng Zhang (Miami, Florida); Tanaji Paul (Miami, Florida); Sohail Mazher Ali Khan Mohammed (Miami, Florida); Denny John (Miami, Florida) |
| ABSTRACT | Methods for large-scale additive manufacturing of high-strength boron nitride nanotubes (BNNT)/aluminum (Al) (e.g., reinforced Al alloy) metal matrix composites (MMCs) (BNNT/Al MMCs), as well as the BNNT/Al MMCs produced by the large-scale additive manufacturing methods, are provided. A combination of ultrasonication and spray drying techniques can produce good BNNT/Al alloy feedstock powders, which can be used in a cold spraying process. |
| FILED | Thursday, April 06, 2023 |
| APPL NO | 18/296570 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/103 (20220101) B22F 1/0547 (20220101) Original (OR) Class B22F 10/64 (20210101) B22F 2301/052 (20130101) B22F 2302/205 (20130101) B22F 2304/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Alloys C22C 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241833 | Mackay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Michael E. Mackay (Middletown, Delaware); Zachary Swain (Newark, Delaware) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | Michael E. Mackay (Middletown, Delaware); Zachary Swain (Newark, Delaware) |
| ABSTRACT | A positive displacement pump for an additive manufacture application includes a motor having a rotatable output shaft, at least one rotatable gear or rotatable screw that is attached to the output shaft of the motor, and a passage defined downstream of said at least one rotatable gear or rotatable screw. The gear or screw is configured to receive material, and expel the material out of the pump at a flow rate proportional to a rotation rate of the output shaft of the motor and at a constant flow rate for a fixed rotation rate of the output shaft regardless of changes in system pressure. |
| FILED | Thursday, April 06, 2023 |
| APPL NO | 18/131669 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Original (OR) Class B29C 64/321 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps F04C 2/18 (20130101) F04C 13/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242120 | Vantsevich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts); THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir V. Vantsevich (Worcester, Massachusetts); David J. Gorsich (Detroit Arsenal, Michigan); Lee Moradi (Worcester, Massachusetts); Jesse R. Paldan (Birmingham, Alabama); Masood Ghasemi (Birmingham, Alabama) |
| ABSTRACT | A method of optimizing vehicle mobility performance includes receiving technical parameters for each wheel associated with wheel power of the particular wheel on a particular terrain. The method includes determining an optimal vehicle mobility performance by determining an optimal tire slippage for one wheel based on the set of technical parameters for the wheel and individually determining an optimal tire slippage for another wheel based on the set of technical parameters for the other wheel. A system may utilize such a method to control mobility performance in a vehicle such as, but not limited to, an autonomous ground vehicle. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/101916 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/18172 (20130101) Original (OR) Class B60W 40/10 (20130101) B60W 2520/28 (20130101) B60W 2552/15 (20200201) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242236 | Best et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael John Best (Redondo Beach, California); Sangvavann Heng (Buena Park, California); Tai Anh Lam (Renton, Washington); Peter Shaw (Artesia, California); Jonathan David Embler (Santa Ana, California) |
| ABSTRACT | A system and method for sending signals at temperatures associated with hypersonic speeds. A window system in a hypersonic aircraft is provided. The window system comprises a transmissive window in an aeroshell of the hypersonic aircraft, a thermal seal, a sensor, and a sensor housing assembly enclosing the sensor. The transmissive window comprises a facesheet and insulating material adjacent to the facesheet. The thermal seal surrounds a perimeter of the facesheet and seals the facesheet to the aeroshell. The window system is radio-frequency transparent at temperatures associated with hypersonic speeds. The window system is configured to operate at an insertion loss of less than one decibel at the hypersonic speeds. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/649563 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 1/40 (20130101) B64C 1/1484 (20130101) B64C 1/1492 (20130101) Original (OR) Class B64C 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242396 | Novak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Goverment of the United States of America, as represented by the Secretary of the Navy (Ariington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Travis G. Novak (Lorton, Virginia); Debra R. Rolison (Arlington, Virginia); Paul A. DeSario (Alexandria, Virginia) |
| ABSTRACT | A method and apparatus for: providing a ceria aerogel and copper nanoparticle catalyst, flowing a hydrogen, carbon monoxide, and water vapor source gas from an inlet into contact with the catalyst to produce a product gas, and flowing the product gas to an outlet. The concentration of carbon monoxide in the product gas is no more than 50% of the concentration of carbon monoxide in the source gas. The concentration of hydrogen in the product gas is no less than 90% of the concentration of hydrogen in the source gas. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/161009 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 12/007 (20130101) B01J 19/0013 (20130101) B01J 19/24 (20130101) B01J 23/10 (20130101) B01J 23/72 (20130101) B01J 35/0013 (20130101) B01J 35/0066 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/16 (20130101) Original (OR) Class C01B 2203/066 (20130101) C01B 2203/0283 (20130101) C01B 2203/1076 (20130101) C01B 2203/1082 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0612 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242487 | BLUMBERG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Southwest Research Institute (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shawn T. BLUMBERG (San Antonio, Texas); Antonio MENCHACA (Seguin, Texas); Christopher DORSEY (San Antonio, Texas); Asa WATERMAN (San Antonio, Texas) |
| ABSTRACT | Purification of bis-quaternary pyridinium oximes (BQPO) which may serve as organophosphorus nerve agent antidotes. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/649581 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/81 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242534 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Tinghu Zhang (Brookline, Massachusetts); Nicholas Paul Kwiatkowski (Brookline, Massachusetts); Nathanael S. Gray (Stanford, California); Zhixiang He (Brookline, Massachusetts); Yanke Liang (Belmont, Massachusetts) |
| ABSTRACT | The present disclosure provides compounds of Formula (I), (II-1), (II-2), (II-3), or (II-4). The compounds of the present disclosure may be inhibitors of kinases (e.g., a cyclin-dependent kinase (CDK) (e.g., CDK7)). In some embodiments, the compounds disclosed herein are selective for inhibiting the activity of a kinase (e.g., CDK7) over certain other kinases (e.g., CDK2, CDK9, CDK12). In certain embodiments, the compounds do not bind or inhibit a 5-hydroxytryptamine (5-HT) receptor. Also provided are pharmaceutical compositions, kits, methods of use, and uses that involve the compounds disclosed herein. In some embodiments, the compounds are useful in inhibiting the activity of a kinase, inhibiting the growth of a cell, inducing apoptosis of a cell, treating a disease, and/or preventing a disease (e.g., proliferative disease, cystic fibrosis). |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/628794 |
| CURRENT CPC | Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242666 | DOTTI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cell Medica, Inc. (Houston, Texas); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | Cell Medica, Inc. (Houston, Texas); The University of North Carolina Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Gianpietro DOTTI (Chapel Hill, North Carolina); Elisa LANDONI (Chapel Hill, North Carolina); Miriam DROSTE (Houston, Texas); Abdijapar SHAMSHIEV (Houston, Texas) |
| ABSTRACT | The present disclosure relates to methods and compositions related to Chimeric Antigen Receptors (“CARs”) and modifications to the framework sequences to eliminate tonic signaling. The compositions include modified binding members having a binding specificity to chondroitin sulfate proteoglycan 4 (CSPG4) and are stable when prepared as single chain antibody (scFv) and incorporated into CARs. The methods further include nucleic acid constructs for the expression of CSPG4 CARs, and the application of the CSPG4 CAR to therapeutic methods for the treatment of cancer. The present disclosure also relates to the modification of humanized framework sequences. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 18/003079 |
| CURRENT CPC | Peptides C07K 14/5418 (20130101) C07K 14/5434 (20130101) C07K 14/5443 (20130101) C07K 16/3053 (20130101) Original (OR) Class C07K 2317/565 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242864 | Moser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sciperio, Inc (Orlando, Florida) |
| ASSIGNEE(S) | Sciperio, Inc (Orlando, Florida) |
| INVENTOR(S) | Janice M. Moser (Oviedo, Florida); Casey W. Perkowski (Winter Park, Florida); Pierce J. Busse (Pensacola, Florida); Kelly Haupfear (Titusville, Florida); Kenneth H. Church (Orlando, Florida) |
| ABSTRACT | A system includes a bioreactor having an inlet and an outlet, a cell-media recirculation loop between the outlet of the bioreactor and the inlet of the bioreactor, and a mature cell separation unit positioned along the cell-media recirculation loop wherein the mature cell separation unit is configured for performing separation of mature cells from immature cells and direction of the immature cells back to the inlet of the bioreactor. The system may further include a storage unit for storing the mature cells. The mature cell separation unit may be further configured to direct the mature cells to a mature cell storage unit. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154230 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 29/18 (20130101) C12M 33/04 (20130101) C12M 41/12 (20130101) C12M 41/26 (20130101) C12M 41/48 (20130101) C12M 47/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242865 | Hazlebeck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Global Algae Technology, LLC (Santee, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Hazlebeck (El Cajon, California); William Rickman (Lebanon, Tennessee) |
| ABSTRACT | Algae harvesting and cultivating systems and methods for producing high concentrations of algae product with minimal energy. In an embodiment, a dead-end filtration system and method includes at least one tank and a plurality hollow fiber membranes positioned in the at least one tank. An algae medium is pulled through the hollow fiber membranes such that a retentate and a permeate are produced. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/133402 |
| CURRENT CPC | Separation B01D 61/22 (20130101) B01D 61/146 (20220801) B01D 63/02 (20130101) B01D 63/04 (20130101) B01D 63/046 (20130101) B01D 65/02 (20130101) B01D 2311/04 (20130101) B01D 2311/06 (20130101) B01D 2311/2626 (20130101) B01D 2311/2688 (20130101) B01D 2313/18 (20130101) B01D 2313/26 (20130101) B01D 2313/50 (20130101) B01D 2315/06 (20130101) B01D 2315/08 (20130101) B01D 2317/02 (20130101) B01D 2317/022 (20130101) B01D 2321/04 (20130101) B01D 2321/18 (20130101) B01D 2321/40 (20130101) B01D 2321/185 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/02 (20130101) C12M 29/04 (20130101) C12M 29/16 (20130101) C12M 29/18 (20130101) C12M 29/20 (20130101) C12M 33/14 (20130101) C12M 41/32 (20130101) C12M 41/44 (20130101) C12M 41/48 (20130101) C12M 45/00 (20130101) C12M 47/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/02 (20130101) C12N 1/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242900 | Adelman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zach N. Adelman (College Station, Texas); Kevin M. Myles (College Station, Texas); Sakiko Okumoto (College Station, Texas) |
| ABSTRACT | The current invention provides vector constructs that are pre-programmed to self-terminate or self-remove at a predetermined time and methods of making the same. The present invention further provides methods for creating organisms containing these vector constructs. Also provided are various transgenic organisms with the vector constructs, including plants, insects, and mammals. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 18/015753 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) Original (OR) Class C12N 15/8213 (20130101) C12N 15/8509 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242902 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Chang C. Liu (Irvine, California); Arjun Ravikumar (Washington, District of Columbia); Garri A. Arzumanyan (Irvine, California); Alex A. Javanpour (San Ramon, California) |
| ABSTRACT | The invention provides compositions comprising highly error-prone polymerases and methods of using the polymerases for rapid evolution of a nucleic acid sequence within host cells. The invention further provides a versatile synthetic biology platform for manipulating DNA replication inside a cell. The invention also provides a mutually orthogonal replication system for manipulating and tuning DNA replication of multiple nucleic acid molecules using the error-prone polymerases. |
| FILED | Friday, October 19, 2018 |
| APPL NO | 16/756813 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) C12N 15/1024 (20130101) C12N 15/1058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242918 | SI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Longlong SI (Cambridge, Massachusetts); Haiqing BAI (Cambridge, Massachusetts); Donald E. INGBER (Cambridge, Massachusetts); Crystal Yuri OH (Cambridge, Massachusetts); Rachelle PRANTIL-BAUN (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are compositions and methods for inducing Type I interferon production. The compositions described comprise immunostimulatory oligonucleotide duplexes including a 5′ terminal monophosphate-CUGA-3′ (SEQ ID NO. 1) sequence. Compositions comprising the immunostimulatory oligonucleotide duplexes described can be used for the treatment of diseases or disorders that respond to interferons. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/926748 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 35/16 (20130101) A61K 39/39 (20130101) A61K 45/06 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242947 | Bose et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arpita Bose (St. Louis, Missouri); Wei Bai (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Arpita Bose (St. Louis, Missouri); Wei Bai (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of a genetically engineered transgenic microorganisms Rhodopseudomonas palustris and methods of making and using the same. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046695 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) C12N 15/52 (20130101) C12N 15/74 (20130101) C12N 2800/101 (20130101) C12N 2820/002 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/625 (20130101) Original (OR) Class Enzymes C12Y 101/05 (20130101) C12Y 102/01057 (20130101) C12Y 103/01086 (20130101) C12Y 401/01039 (20130101) C12Y 402/01027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242969 | Irvine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Imperial College Innovations Limited (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell J. Irvine (Arlington, Massachusetts); Jason Y.H. Chang (Cambridge, Massachusetts); Sylvain Ladame (Tring, United Kingdom); Dana Al-Sulaiman (London, United Kingdom) |
| ABSTRACT | The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composition comprising at least one polymer and least one Peptide Nucleic Acid (PNA). The present disclosure additionally relates to a method of detecting an analyte in interstitial fluid (ISF), comprising contacting the device to a subject, for example, to human skin. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/097012 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 41/36 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6823 (20130101) C12Q 2565/629 (20130101) C12Q 2565/1025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242997 | Myers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HudsonAlpha Institute for Biotechnology (Huntsville, Alabama); Board of Directors of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard M. Myers (Huntsville, Alabama); James D. Brooks (Stanford, California); Marie K. Kirby (Atlanta, Georgia) |
| ABSTRACT | The present disclosure provides for and relates to the identification of novel biomarkers for diagnosis and prognosis of prostate cancer or the biochemical reoccurence of prostate cancer. The biomarkers of the invention show altered methylation levels of certain CpG loci relative to normal prostate tissue, as set forth. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/101052 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243268 | Hayek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Elia Hayek (Wrentham, Massachusetts); Victor Hugo Silva Correia (Milton Mills, New Hampshire) |
| ABSTRACT | An airfoil for a turbine engine includes a body defining a pressure side and a suction side, the body extending between a leading edge and a trailing edge and also extending radially to define an outer edge. A radially-extending plenum can be disposed at the outer edge of the airfoil. A flared portion can be disposed at the outer edge of the body extending from the suction side. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/184182 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/20 (20130101) Original (OR) Class F01D 5/186 (20130101) F01D 25/12 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/30 (20130101) F05D 2240/306 (20130101) F05D 2240/307 (20130101) F05D 2260/202 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243343 | SAHIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Ozgur SAHIN (New York, New York); Onur CAKMAK (New York, New York); Xi CHEN (New York, New York) |
| ABSTRACT | Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/167275 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 3/067 (20130101) B05D 7/24 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 65/4845 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/02 (20130101) C12N 1/125 (20210501) C12N 1/205 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/075 (20210501) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243698 | Coward et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | James F. Coward (Washougal, Washington); David Alen Pechner (San Jose, California); Gregory Mitchell (Elk Grove, California); Ji Li (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James F. Coward (Washougal, Washington); David Alen Pechner (San Jose, California); Gregory Mitchell (Elk Grove, California); Ji Li (San Jose, California) |
| ABSTRACT | Shortwave infrared (SWIR) hyperspectral imaging (HSI) systems comprise a supercontinuum laser source configured to illuminate objects and a receiver comprising a spectrometer configured to receive light reflected from the objects. In some cases, hyperspectral images can be created by raster scanning of the source/receiver across a scene. The supercontinuum laser source provides active illumination to allow collection of hyperspectral imagery during day (including overcast conditions) and night. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/929286 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/108 (20130101) Original (OR) Class G01J 3/2823 (20130101) G01J 2003/2826 (20130101) Image Data Processing or Generation, in General G06T 7/521 (20170101) G06T 2207/10036 (20130101) G06T 2207/10048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243900 | Hamilton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. Hamilton (Dayton, Ohio); James Park (Springfield, Virginia); Woo Yong Jang (Xenia, Ohio); Nathan E. Zechar (Mason, Ohio) |
| ABSTRACT | The present invention relates to diagnostic device for the characterization of electromagnetic material properties and a method of making and using same. Unlike current diagnostic devices, the disclosed diagnostic device comprises a novel waveguide system and is suitable for the characterization of electromagnetic material properties such as permittivity, permeability, and the loss tangent of materials over a broad temperature and pressure range. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 17/989253 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 27/2617 (20130101) G01R 27/2694 (20130101) G01R 33/1223 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244029 | CHARLES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William CHARLES (Albany, New York); Douglas COOLBAUGH (Albany, New York); Douglas LA TULIPE (Albany, New York); Gerald L. LEAKE, Jr. (Albany, New York) |
| ABSTRACT | There is set forth herein a method including building a first photonics structure using, wherein the building the first photonics structure includes fabricating one or more photonics device. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/151900 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/12 (20130101) G02B 6/13 (20130101) G02B 6/43 (20130101) G02B 6/428 (20130101) G02B 6/4245 (20130101) G02B 6/4283 (20130101) G02B 6/12002 (20130101) G02B 6/12004 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/101 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244074 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Magic Leap, Inc. (Plantation, Florida) |
| ASSIGNEE(S) | Magic Leap, Inc. (Plantation, Florida) |
| INVENTOR(S) | Chunyu Gao (Tucson, Arizona); Yuxiang Lin (Tucson, Arizona); Hong Hua (Tucson, Arizona) |
| ABSTRACT | The present invention comprises a compact optical see-through head-mounted display capable of combining, a see-through image path with a virtual image path such that the opaqueness of the see-through image path can be modulated and the virtual image occludes parts of the see-through image and vice versa. |
| FILED | Tuesday, April 04, 2023 |
| APPL NO | 18/295685 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 13/06 (20130101) G02B 25/001 (20130101) G02B 26/00 (20130101) Original (OR) Class G02B 27/144 (20130101) G02B 27/0172 (20130101) G02B 27/283 (20130101) G02B 27/1066 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 37/02 (20130101) Image Data Processing or Generation, in General G06T 19/006 (20130101) Pictorial Communication, e.g Television H04N 23/45 (20230101) H04N 23/698 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244416 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Devices and techniques for communicating a programmable atomic operator to a memory controller are described herein. A memory controller can receive a memory request and extract a command indicator that indicates a programmable atomic operator (PAO) command from the memory request. The memory controller can then extract a PAO index from the request and invoke the PAO based on the PAO index. |
| FILED | Monday, March 27, 2023 |
| APPL NO | 18/126869 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0604 (20130101) G06F 3/0644 (20130101) G06F 3/0659 (20130101) Original (OR) Class G06F 3/0679 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244906 | Becnel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Becnel (Salt Lake City, Utah); Pierre-Emmanuel Gaillardon (Salt Lake City, Utah) |
| ABSTRACT | Techniques for implementing a multi-branch neural network in an edge network are disclosed, where the multi-branch neural network is configured to infer latent features from fused sensor time series exogenous inputs. A multi-branch neural network is configured to include a LSTM branch and two FC branches. The multi-branch neural network is deployed on an edge node, which receives raw input from sensors. The raw input is fed into the LSTM branch and into the second FC branch. The raw input is fed into a normalization block that performs feature-wise normalization to generate normalized input. The normalized input is fed into the first FC block. The multi-branch neural network is used to generate a latent inference based on outputs provided by the LSTM branch and the two FC branches. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592230 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0445 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245388 | Young et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRX Systems, Inc. (Greenbelt, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis Young (Rockville, Maryland); Daniel Hakim (Silver Spring, Maryland); Daniel Franchy (Catonsville, Maryland); Jared Napora (Severn, Maryland); John Karvounis (Bowie, Maryland); Jonathan Fetter Degges (Washington, District of Columbia); Tim Wang (Germantown, Maryland); Benjamin Funk (Hanover, Maryland); Carole Teolis (Glendale, Maryland); Carol Politi (Bethesda, Maryland); Stuart Woodbury (Ellicott City, Maryland) |
| ABSTRACT | Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880530 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3867 (20200801) Electric Digital Data Processing G06F 30/13 (20200101) Image Data Processing or Generation, in General G06T 17/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245575 | Osipychev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Denis Osipychev (Huntsville, Alabama); Dragos D. Margineantu (Tukwila, Washington) |
| ABSTRACT | A method is provided for avoiding a conflict during a flight of an aircraft that includes a defined route of travel. The method includes receiving observations of states of the aircraft and a nearby obstacle in an environment of the aircraft as the aircraft travels the defined route. The method includes applying the states to a reinforcement learning framework to predict states of the aircraft to avoid a conflict between the aircraft and the nearby obstacle. The reinforcement learning framework determines maneuvers of the aircraft to avoid the conflict, using a policy trained using a surrogate model of the environment in which movements of the aircraft and the nearby obstacle are simulated, and determines the predicted states of the aircraft from the maneuvers. A collision avoidance trajectory is generated from the predicted states of the aircraft, and output for guidance, navigation or control of the aircraft. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/649883 |
| CURRENT CPC | Traffic Control Systems G08G 5/003 (20130101) G08G 5/006 (20130101) G08G 5/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245901 | Currie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the Unites States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Marc Currie (Washington, District of Columbia); Virginia D. Wheeler (Alexandria, Virginia) |
| ABSTRACT | A method for locally annealing and crystallizing a thin film by directing ultrashort optical pulses from an ultrafast laser into the film. The ultrashort pulses can selectively produce an annealed pattern and/or activate dopants on the surface or within the film. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/113385 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/477 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230246093 | ONTALUS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GLOBALFOUNDRIES U.S. Inc. (Malta, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viorel ONTALUS (Unionville, Connecticut); Justin C. LONG (Poughkeepsie, New York); Robert K. BAIOCCO (Poughquag, New York) |
| ABSTRACT | The present disclosure relates to semiconductor structures and, more particularly, to a bipolar transistor and methods of manufacture. The structure includes: a collector region in a semiconductor substrate; a base region adjacent to the collector region; and an emitter extending above the base region and comprising semiconductor material and a hardmask surrounding a lower portion of the semiconductor material. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587347 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/732 (20130101) Original (OR) Class H01L 29/0804 (20130101) H01L 29/1004 (20130101) H01L 29/66287 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230247910 | Qing |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Quan Qing (Chandler, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Quan Qing (Chandler, Arizona) |
| ABSTRACT | A magnetic tunneling junction (MTJ) device structure and the method of constructing such device are disclosed. Also disclosed are methods of using the device for spin-dependent transport characterization through biomolecules for structure and dynamic function analysis in physiological environments. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 18/004660 |
| CURRENT CPC | Electric solid-state devices not otherwise provided for H10N 50/01 (20230201) Original (OR) Class H10N 50/10 (20230201) H10N 50/20 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230240522 | Sheffield et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BRIGHAM YOUNG UNIVERSITY (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob L. Sheffield (Provo, Utah); Amanda Lytle (Provo, Utah); Jaocb G. Hunter (West Lafayette, Indiana); Lance Hyatt (State College, Pennsylvania); Larry L. Howell (Orem, Utah) |
| ABSTRACT | A device and methodology for cleaning optical instruments. The device includes a sheath, a wiper mechanism, and an actuator. The sheath attaches to the optical instrument such that the wiper mechanism is in proximity to the lens of the optical instrument. The wiper mechanism includes an blade and an compliant deployment system having first and second curved cross members attached to the blade and sheath such that they bias the blade in a first state where the blade in a deployed position but can deform allowing the blade to transition to a second state in a stored position. The actuator maintains tension on the blade to keep the blade in a second state and when the actuator releases tension on the blade spring energy stored by the deformation of the curved cross members is released transitioning the blade to the first deployed position providing a wipe of the wiper mechanism. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 18/000804 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/126 (20130101) Original (OR) Class A61B 90/70 (20160201) A61B 2090/701 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240539 | GEORGAKOUDI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); Lahey Clinic, Inc. (Burlington, Massachusetts) |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts); Lahey Clinic, Inc. (Burlington, Massachusetts) |
| INVENTOR(S) | Irene GEORGAKOUDI (Winchester, Massachusetts); Einstein GNANATHEEPAM (Medford, Massachusetts); Robert Michael TROUT (Medford, Massachusetts); Thomas SCHNELLDORFER (Arlington, Massachusetts) |
| ABSTRACT | Methods for improved imaging of internal tissue structures, such as lesions in the peritoneum, are disclosed employing color-weighted Polarization Enhanced Light (mPEL) imaging. A target tissue can be Illuminated with light of defined polarization at a plurality of wavelengths or wavelength bands. Scattered light from the tissue is collected and its polarization states analyzed and detected either via a polarization sensitive camera or a combination or polarizing filters and a standard camera. Light detected at distinct polarization states and colors is weighted by a factor and combined to yield an image that results in optimized visualization of lesions and/or discrimination of malignant from benign lesions. The factors may be identified based on a combination of Monte Carlo simulations and regression analysis to yield enhanced sensitivity to the tissue scattering power. Alternatively, the factors may be identified through machine learning based optimization algorithms to optimize tissue classification. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/101294 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) Original (OR) Class A61B 5/0084 (20130101) A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230240977 | Wrenn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven P. Wrenn (Swarthmore, Pennsylvania); Stephen Dicker (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention includes a construct that comprises at least one microbubble encapsulated within the aqueous core of a microcapsule. The present invention also includes a pharmaceutical composition comprising a construct comprising at least one microbubble encapsulated within the aqueous core of a microcapsule. The present invention further includes a method of imaging a tissue or organ in a subject, a method of delivering a therapeutic cargo to a tissue or organ in a subject, and a method of treating a disease or disorder in a subject. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/108464 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) Original (OR) Class A61K 9/1271 (20130101) A61K 9/5031 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241026 | NGO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | John T. NGO (Cambridge, Massachusetts); Mary DUNLOP (Newton, Massachusetts); Elliot Parker TAGUE (Brookline, Massachusetts); Nathan Michael TAGUE (Brookline, Massachusetts); Alexander Michael MARZILLI (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to polypeptide systems using drug-controlled peptide docking domains and cognate docking domain-binding peptides and their use to control cellular signaling, activity, and/or gene expression. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/173277 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Original (OR) Class A61K 31/4965 (20130101) A61K 31/5377 (20130101) A61K 47/6425 (20170801) Peptides C07K 14/02 (20130101) C07K 14/47 (20130101) C07K 14/705 (20130101) C07K 14/43595 (20130101) C07K 2319/03 (20130101) C07K 2319/60 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241219 | Weitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Ho Cheung Shum (Cambridge, Massachusetts); Daeyeon Lee (Cambridge, Massachusetts); Insun Yoon (Cambridge, Massachusetts); Jin-Woong Kim (Cambridge, Massachusetts) |
| ABSTRACT | The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be at least partially biocompatible and/or biodegradable. The vesicles may be formed, according to one aspect, by forming a multiple emulsion comprising a first droplet surrounded by a second droplet, which in turn is surrounded by a third fluid, where the second droplet comprises lipids and/or polymers, and removing fluid from the second droplet, e.g., through evaporation or diffusion, until a vesicle is formed. In certain aspects, the size of the vesicle may be controlled, e.g., through osmolarity, and in certain embodiments, the vesicle may be ruptured through a change in osmolarity. In some cases, the vesicle may contain other species, such as fluorescent molecules, microparticles, pharmaceutical agents, etc., which may be released upon rupture. Yet other aspects of the invention are generally directed to methods of making such vesicles, kits involving such vesicles, or the like. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940196 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) A61K 9/501 (20130101) A61K 9/1273 (20130101) A61K 9/1277 (20130101) A61K 9/5031 (20130101) A61K 9/5089 (20130101) A61K 47/34 (20130101) Original (OR) Class A61K 47/6907 (20170801) A61K 47/6915 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241346 | VAN REEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island); EMMA PENDLETON BRADLEY HOSPITAL (EAST PROVIDENCE, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eliza VAN REEN (East Greenwich, Rhode Island); Gustavo E. FERNANDES (Providence, Rhode Island); Jingming XU (Providence, Rhode Island); Mary A. CARSKADON (Providence, Rhode Island) |
| ABSTRACT | Systems tune, control, or remediate the intrinsic Circadian clock. A light controller sets spectral distribution, intensity of a bioactive spectral band to shift or entrain circadian response to enhance performance and/or synchronize with local or expected conditions. The systems enhance performance under conditions that might be changing, disrupted, or otherwise present an irregular phase or unnatural change in the subject's circadian status, for example, due to geographically discontinuous activity or spectrally deficient workplace illumination, or due to divergent individual sleep/wake behaviors of subjects in a structured group activity. An illumination recipe that compensates for the deficiency of lighting or of participant sleep or behavior patterns, or age- or disease-related changes, to evoke, shift, or align circadian response and improve behaviors such as classroom alertness, relaxation, excitability, attention, or focus. Systems may receive sensed light values and automatically apply high- and/or low-CER illumination to effect the intended circadian phase. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154600 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 21/02 (20130101) Original (OR) Class A61M 2021/0044 (20130101) A61M 2205/3306 (20130101) A61M 2205/3553 (20130101) A61M 2205/3569 (20130101) A61M 2205/3592 (20130101) A61M 2230/06 (20130101) A61M 2230/50 (20130101) A61M 2230/63 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0618 (20130101) A61N 2005/0627 (20130101) A61N 2005/0628 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241586 | Notestein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin M. Notestein (Evanston, Illinois); Peter C. Stair (Santa Fe, New Mexico); Huan Yan (Evanston, Illinois) |
| ABSTRACT | Tandem catalysts for the dehydrogenation of alkanes and/or alcohols in tandem with selective hydrogen combustion are provided. Also provided are methods of making the catalysts and methods of using the catalysis for the dehydrogenation of alkanes and/or alcohols. The catalysts include a support having a surface, dehydrogenation catalysts particles dispersed on the surface of the support, and a porous selective hydrogen combustion catalyst overcoat on the dehydration catalyst particles. The catalysts couple dehydrogenation with selective hydrogen combustion in a sequence of reactions occurring in tandem to shift the equilibrium of the dehydrogenation towards higher conversion. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/927200 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 23/08 (20130101) B01J 23/42 (20130101) Original (OR) Class B01J 35/006 (20130101) B01J 35/0013 (20130101) B01J 37/0221 (20130101) B01J 37/0228 (20130101) B01J 37/0244 (20130101) Acyclic or Carbocyclic Compounds C07C 5/3337 (20130101) C07C 2521/04 (20130101) C07C 2523/08 (20130101) C07C 2523/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241591 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pu-Xian Gao (Coventry, Connecticut); Wenxiang Tang (Vemon, Connecticut) |
| ABSTRACT | Manganese-cobalt (Mn—Co) spinel oxide nanowire arrays are synthesized at low pressure and low temperature by a hydrothermal method. The method can include contacting a substrate with a solvent, such as water, that includes Mn04- and Co2 ions at a temperature from about 60° C. to about 120° C. The method preferably includes dissolving potassium permanganate (KMn04) in the solvent to yield the Mn04- ions. the substrate is The nanoarrays are useful for reducing a concentration of an impurity, such as a hydrocarbon, in a gas, such as an emission source. The resulting material with high surface area and high materials utilization efficiency can be directly used for environment and energy applications including emission control systems, air/water purifying systems and lithium-ion batteries. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/166577 |
| CURRENT CPC | Separation B01D 53/864 (20130101) B01D 2255/405 (20130101) B01D 2255/2073 (20130101) B01D 2255/9202 (20130101) B01D 2255/9205 (20130101) B01D 2255/9207 (20130101) B01D 2255/20746 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/005 (20130101) B01J 23/78 (20130101) B01J 23/8892 (20130101) Original (OR) Class B01J 35/04 (20130101) B01J 35/0013 (20130101) B01J 37/0215 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 51/40 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241597 | Findlater et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Findlater (Merced, California); Guigen Li (Lubbock, Texas) |
| ABSTRACT | The present invention includes compositions and methods of using a molecule of Formula I: wherein R is selected from methyl, ethyl, propyl, isopropyl, butyl, phenyl, cyclohexyl, fluoro, chloro, methoxy, ethoxy, butoxy, phenoxy, aryl, alkene, alkyne, and heterocyclic. The molecule of Formula I is a ligand until a metal is added, at which time the molecule is a catalyst. |
| FILED | Saturday, January 28, 2023 |
| APPL NO | 18/161048 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 38/68 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241778 | Walsh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Conor J. Walsh (Cambridge, Massachusetts); Tommaso Proietti (Cambridge, Massachusetts); Ciarán O'Neill (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods related to the operation of wearable robotic systems are disclosed. In one embodiment, a wearable robotic system may be calibrated by correlating a measured joint angle and an actuation pressure. In another embodiment, a wearable robotic system may be operated to provide gravity compensation by operating one or more actuators of the system based on an estimated current pose of a first body portion associated with a joint and calibration parameters of the system to support at least a portion of a weight of the first body portion. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/081470 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) B25J 9/142 (20130101) B25J 9/1692 (20130101) Original (OR) Class B25J 13/088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242479 | Toscano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Pasquale Toscano (Baltimore, Maryland); Vinayak S. Khodade (Baltimore, Maryland) |
| ABSTRACT | Alkylamine-substituted perthiocarbamates capable of controllable release of hydropersulfides (RSSH) and carbonyl sulfide (COS) and their use in treating or preventing ischemia-reperfusion injury are described. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/159447 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Acyclic or Carbocyclic Compounds C07C 321/14 (20130101) C07C 333/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242495 | Baxter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan D. Baxter (Merced, California); Jordan Galloway (Merced, California) |
| ABSTRACT | Provided are compounds that can find use as nitrosation reagents. Provided are nitrosation methods that include reacting a substrate with one of the provided nitrosation reagents and thereby generating a nitrosation product. Provided are kits including a nitrosation reagent. Provided are compositions wherein the nitrosation reagent is enriched in the 15N isotope. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/928519 |
| CURRENT CPC | Heterocyclic Compounds C07D 275/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242820 | Fini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Elham Fini (Phoenix, Arizona); Masoumeh Mousavi (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elham Fini (Phoenix, Arizona); Masoumeh Mousavi (Tempe, Arizona) |
| ABSTRACT | Sulfur copolymerization includes combining elemental sulfur with modified bitumen to yield a mixture, blending the mixture, and curing the mixture to yield a copolymerized modified bitumen. The modified bitumen includes waste vegetable oil. Inverse vulcanization includes combining an unsaturated fatty acid and an alkaline earth metal (hydr)oxide to yield a mixture, combining elemental sulfur with the mixture, and processing the mixture to yield a sulfur copolymer. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/162162 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/06 (20130101) Compositions of Macromolecular Compounds C08L 95/00 (20130101) C08L 2555/60 (20130101) Working-up Pitch, Asphalt, Bitumen, Tar; Pyroligneous Acid C10C 3/10 (20130101) C10C 3/023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242872 | Demirci et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Utkan Demirci (Stanford, California); Erkan Tüzel (Natick, Massachusetts); James Leonard Kingsley (Worcester, Massachusetts); Thiruppathiraja Chinnasamy (Tamilnadu, India) |
| ABSTRACT | A microfluidic chip is provided for self-sorting highly motile, morphologically normal sperm cell with high DNA integrity from a fresh semen sample. The sperm self-sorting microfluidic chip has one or more inlet chambers, and sperm collection outlet chamber(s), and the middle of the channel features various micro-fabricated structures in different geometrical shapes and orientations, with varying periodicities and patterns, such as an array of micro-fabricated pillars that facilitate the transport of the active and healthy sperm into the outlet chamber. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/114022 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) B01L 3/502761 (20130101) Apparatus for Enzymology or Microbiology; C12M 47/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0612 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242902 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Chang C. Liu (Irvine, California); Arjun Ravikumar (Washington, District of Columbia); Garri A. Arzumanyan (Irvine, California); Alex A. Javanpour (San Ramon, California) |
| ABSTRACT | The invention provides compositions comprising highly error-prone polymerases and methods of using the polymerases for rapid evolution of a nucleic acid sequence within host cells. The invention further provides a versatile synthetic biology platform for manipulating DNA replication inside a cell. The invention also provides a mutually orthogonal replication system for manipulating and tuning DNA replication of multiple nucleic acid molecules using the error-prone polymerases. |
| FILED | Friday, October 19, 2018 |
| APPL NO | 16/756813 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) C12N 15/1024 (20130101) C12N 15/1058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242947 | Bose et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arpita Bose (St. Louis, Missouri); Wei Bai (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Arpita Bose (St. Louis, Missouri); Wei Bai (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of a genetically engineered transgenic microorganisms Rhodopseudomonas palustris and methods of making and using the same. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046695 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) C12N 15/52 (20130101) C12N 15/74 (20130101) C12N 2800/101 (20130101) C12N 2820/002 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/625 (20130101) Original (OR) Class Enzymes C12Y 101/05 (20130101) C12Y 102/01057 (20130101) C12Y 103/01086 (20130101) C12Y 401/01039 (20130101) C12Y 402/01027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243765 | Ros et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alexandra Ros (Phoenix, Arizona); Daihyun Kim (Mesa, Arizona); Diandra Doppler (Scottsdale, Arizona); Jorvani Cruz Villarreal (Tempe, Arizona); Richard Kirian (Tempe, Arizona); Reza Nazari (Tempe, Arizona); Sahir Gandhi (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandra Ros (Phoenix, Arizona); Daihyun Kim (Mesa, Arizona); Diandra Doppler (Scottsdale, Arizona); Jorvani Cruz Villarreal (Tempe, Arizona); Richard Kirian (Tempe, Arizona); Reza Nazari (Tempe, Arizona); Sahir Gandhi (Tempe, Arizona) |
| ABSTRACT | A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel. The timing of sample droplets in the stream of fluid ejected through the nozzle is controlled by applying a triggering signal to electrodes positioned in the electrode chambers of the single-piece component. |
| FILED | Tuesday, April 04, 2023 |
| APPL NO | 18/295761 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0241 (20130101) B01L 3/502715 (20130101) B01L 2300/0645 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/201 (20130101) G01N 23/20025 (20130101) Original (OR) Class G01N 35/1016 (20130101) G01N 2035/1034 (20130101) G01N 2223/30 (20130101) G01N 2223/054 (20130101) G01N 2223/203 (20130101) G01N 2223/604 (20130101) G01N 2223/612 (20130101) G01N 2223/637 (20130101) G01N 2223/1016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243794 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuming Huang (Ithaca, New York); Christopher K. Ober (Ithaca, New York) |
| ABSTRACT | Polymer nanostructures and compositions, devices, and systems comprising polymer nanostructures. In various examples, a composition, a device, or a system comprises a plurality of polymer nanostructures. The polymer nanostructures are disposed on a surface of a substrate. In various examples, the polymer nanostructures are disposed in pre-determined pattern on a surface of a substrate. In various examples, the polymer nanostructures are self-supporting. In various examples, a polymer nanostructure comprises a polypeptide group or the like. In various examples, a polymer nanostructure comprises an end group, such as, for example, a fluorescent end group, or the like. In various examples, a system is a sensor, which can be used to analyze a sample. In various examples, a composition, a device, or a system is used to analyze samples, such as, for example, samples comprising one or more volatile organic compound(s). |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103274 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/0047 (20130101) Original (OR) Class G01N 2021/6439 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243812 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gilyong Lee (Boston, Massachusetts); Sung-Jin Park (Johns Creek, Georgia); Kevin Kit Parker (Cambridge, Massachusetts); Andre G. Kleber (Boston, Massachusetts) |
| ABSTRACT | Engineered cardiac tissue structures and methods for forming the engineered cardiac tissue structures are provided herein. An example engineered cardiac tissue structure includes a support having a first side and a first engineered cardiac tissue layer disposed at the first side of the support. The first engineered cardiac tissue layer can include a geometrically insulated cardiac tissue node. Another example engineered cardiac tissue structure includes a support, a first engineered cardiac tissue layer, and a second engineered cardiac tissue layer. Excitation and contraction of the first engineered cardiac tissue layer bends the support and strains the second engineered cardiac tissue layer inducing excitation and contraction of the second engineered cardiac tissue layer. The excitation and contraction of the second engineered cardiac tissue layer bends the support and strains the first engineered cardiac tissue layer inducing excitation and contraction of the first engineered cardiac tissue layer thereby producing antagonistic cyclic contractions. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/096629 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5061 (20130101) G01N 33/5088 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243846 | JARROLD et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. JARROLD (Bloomington, Indiana); Corrine A. LUTOMSKI (Bloomington, Indiana) |
| ABSTRACT | The present disclosure relates to methods of identifying components present in intact lipoprotein particles. Methods provided include single particle mass spectrometry, such as charge detection mass spectrometry (CDMS). Distinct subtypes and subpopulations that exist within lipoprotein density classes are determined based on simultaneously measured m/z and charge of ionized lipoprotein particles. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/298514 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 33/6848 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/025 (20130101) H01J 49/40 (20130101) H01J 49/0068 (20130101) H01J 49/4225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244006 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daeyeon Lee (Wynnewood, Pennsylvania); Baek Min Kim (Kaejeon, South Korea) |
| ABSTRACT | Polymer-infiltrated nanoparticle films (PINFs) that have high volume fractions (>50 vol %) of nanoparticles (NPs) possess enhanced properties making them ideal for various applications. Capillary rise infiltration (CaRI) of polymer and solvent-driven infiltration of polymer (SIP) into pre-assembled NP films have emerged as versatile approaches to fabricate PINFs. Although these methods are ideal for fabricating PINFs with homogenous structure, several applications including separations and photonic/optical coatings would benefit from a method that enables scalable manufacturing of heterostructured (i.e., films with variation in structural properties such as porosity, composition, refractive indices etc.) PINFs. In this work, a new technique is developed for fabricating heterostructured PINFs with cavities based on CaRI. A bilayer composed of densely packed inorganic NP layer atop polymer NP layer is thermally annealed above the glass transition temperature of the polymer NP, which induces CaRI of the polymer into the interstices of the inorganic NP layer. Exploiting the difference in the sizes of the two particles, heterostructured double stack PINFs composed of a PINF and a layer with large cavities are produced at a moderate temperature (<200° C.). Using these heterostructured PINFs, Bragg reflectors that can detect the presence of wetting agents in water are fabricated. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 18/051624 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 7/06 (20130101) C08J 2325/06 (20130101) Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) G02B 1/18 (20150115) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244021 | Chrysler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin D. Chrysler (Tucson, Arizona); Jianbo Zhao (Tucson, Arizona); Raymond K. Kostuk (Tucson, Arizona) |
| ABSTRACT | Methods and systems are described that enable manufacturing of holograms with high spatial frequencies and allow composite master holograms to be formed in reflection configurations. An example system for replicating transmission-type holographic elements includes one or more prisms positioned to receive an illumination beam on a first face. A composite master holographic element is positioned in contact with a second face of the one or more prisms to receive the illumination beam after propagation through he one or more prisms. The composite master hologram includes a reference beam component and an object beam component. The replication hologram is positioned in contact with a third face of the one or more prisms to receive, upon illumination of the master HOE by the illumination beam, a holographic exposure comprising first order diffracted illumination from both the reference beam component and object beam component at an exposure region of the copy HOE. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 18/002738 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/003 (20130101) G02B 5/26 (20130101) G02B 5/32 (20130101) Original (OR) Class G02B 5/045 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244484 | Ghodrati et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Soroush Ghodrati (La Jolla, California); Hadi Esmaeilzadeh (San Diego, California) |
| ABSTRACT | Methods, apparatus and systems that relate to hardware accelerators of artificial neural network (ANN) performance that significantly reduce the energy and area costs associated with performing vector dot-product operations in the ANN training and inference tasks. Specifically, the methods, apparatus and systems reduce the cost of bit-level flexibility stemming from aggregation logic by amortizing related costs across vector elements and reducing complexity of the cooperating narrower bitwidth units. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 18/004802 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3822 (20130101) G06F 9/3877 (20130101) G06F 9/30032 (20130101) G06F 9/30036 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244819 | Mishra et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabhat Kumar Mishra (Gainesville, Florida); Hansika M. Weerasena Loku Kattadige (Gainesville, Florida); Thelijjagoda Subodha Nadeeshan Charles (Matara, Sri Lanka) |
| ABSTRACT | The present disclosure presents systems and methods of secure communication by a system-on-chip. One such method comprises receiving, by a sender of a network-on-chip component of the system-on-chip, a message sequence; transforming, by the sender of the network-on-chip component of the system-on-chip, the message sequence into a pseudo-message sequence with an all-or-nothing transform; performing key-less encryption, by the sender of the network-on-chip component of the system-on-chip, of the pseudo-message sequence to obtain a ciphertext message sequence using a chaffing and winnowing scheme; and transmitting, by the sender of the network-on-chip component of the system-on-chip, the ciphertext message sequence to a receiver of the network-on-chip component of the system-on-chip. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 17/973768 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/72 (20130101) Original (OR) Class G06F 21/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244901 | Trivedi et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Ranjan Trivedi (Urbana, Illinois); Shamma Nasrin (Urbana, Illinois); Priyesh Shukla (Urbana, Illinois); Nastaran Darabi (Urbana, Illinois); Maeesha Binte Hashem (Urbana, Illinois); Ahmet Enis Cetin (Urbana, Illinois) |
| ABSTRACT | In accordance with the principles herein, a co-design approach for compute-in-memory inference for deep neural networks (DNN) is set forth. Multiplication-free function approximators are employed along with a co-adapted processing array and compute flow. Resulting methods, systems, devices, and algorithms in accordance with the principles herein overcome many deficiencies in the currently available in—methods, systems, devices, and algorithms (in-SRAM) DNN processing devices. Systems, devices, and algorithms constructed in accordance with the co-adapted implementation herein seamlessly extends to multi-bit precision weights, eliminates the need for DACs, and easily extends to higher vector-scale parallelism. Additionally, a SRAM-immersed successive approximation ADC (SA-ADC) can be constructed, where the parasitic capacitance of bit lines of SRAM array can be exploited as a capacitive DAC. The dominant area overhead in SA-ADC, due to its capacitive DAC, can allow low area implementation of within-SRAM SA-ADC. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/161830 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244980 | CALDERBANK et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur Robert CALDERBANK (Durham, North Carolina); Jingzhen HU (Durham, North Carolina); Qingzhong LIANG (Durham, North Carolina) |
| ABSTRACT | Technologies for performing error correction in a quantum circuit of a quantum computing system are disclosed. A quantum error correction code (QECC) is selected. The QECC is associated with a codespace. The quantum computing system identifies, based on one or more properties of the QECC, one or more diagonal physical gates in the quantum circuit that induces a target logical gate and preserves the codespace. The quantum computing system configures the quantum computing circuit to implement a quantum error correction protocol using the QECC and at least one of the identified diagonal physical gates. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/102387 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/1044 (20130101) Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) G06N 10/70 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245722 | LISZKA et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); BASF SE (Ludwigshafen, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael LISZKA (San Diego, None); Zachary WU (Pasadena, None); Kevin YANG (Pasadena, None) |
| ABSTRACT | The disclosure provides systems and methods for generating a signal peptide amino acid sequence using deep learning. |
| FILED | Thursday, June 04, 2020 |
| APPL NO | 18/007987 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/20 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245879 | Jarrold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. Jarrold (Bloomington, Indiana); Joanna A. Hogan (Hillsboro, Oregon) |
| ABSTRACT | An instrument for analyzing ions may include an ion source to generate ions, at least one ion processing instrument to process the generated ions by one or both of filtering the ions according to a molecular characteristic and dissociating the ions, and an electrostatic linear ion trap (ELIT) to receive and trap ions exiting the at least one ion processing instrument. The ELIT has first and second ion mirrors separated by a charge detection cylinder, and is configured such that trapped ions oscillate back and forth through the charge detection cylinder between the first and second ion mirrors with a duty cycle, corresponding to a ratio of time spent by the trapped ions traversing the charge detection cylinder and total time spent by the trapped ions traversing a combination of the first and second ion mirrors and the charge detection cylinder during one complete oscillation cycle, of approximately 50%. |
| FILED | Monday, March 27, 2023 |
| APPL NO | 18/190168 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/025 (20130101) H01J 49/0036 (20130101) H01J 49/48 (20130101) H01J 49/4245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230246229 | BOLTON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Octet Scientific, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Onas James BOLTON (Pepper Pike, Ohio); Emily Janine DICKENS (Cleveland, Ohio); Mark Richard RUBINO (Holland, Michigan) |
| ABSTRACT | Provided herein are novel organic sulfonic acid or sulfonate zinc-battery electrolyte additive chemicals with surprising advantageous properties such as, but not limited to, stability and the ability to facilitate zinc plating while limiting the formation of zinc dendrites. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/157700 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0563 (20130101) Original (OR) Class H01M 2300/0005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230246231 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xiaowei Li (Philadelphia, Pennsylvania); Yongwei Zheng (Philadelphia, Pennsylvania); Christopher Li (Bala Cynwyd, Pennsylvania) |
| ASSIGNEE(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Xiaowei Li (Philadelphia, Pennsylvania); Yongwei Zheng (Philadelphia, Pennsylvania); Christopher Li (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | A solid polymer electrolyte including a comb-chain crosslinked network formed by reacting poly(glycidyl methacrylate) with a functionalized poly(ethylene glycol) or functionalized poly(ethylene oxide). Batteries including the solid polymer electrolytes, a cathode, and a metal anode or one or more lithium salts are also described. A process of preparing the solid polymer electrolyte involves reacting a poly(glycidyl methacrylate) with a functionalized poly(ethylene glycol) or functionalized poly(ethylene oxide) to form a crosslinked network in a single-step polymerization process. The solid polymer electrolyte provides improved resistance to lithium dendrite formation and has excellent physical and electrical properties that make it particularly suitable for use in lithium batteries. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 18/003512 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0565 (20130101) Original (OR) Class H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230246321 | Friedman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Amherst College (Amherst, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan R. Friedman (Amherst, Massachusetts) |
| ABSTRACT | Improved loop-gap resonators applicable to Electron-Spin Resonance spectroscopy and to quantum computing employ interdigitated capacitor structures to dramatically increase the capacitance of the resonator, along with corresponding decreases in loop size to enable measurements of small-volume samples or individual quantum bits (qubits). The interdigitated-capacitor structures are designed to minimize parasitic inductance. |
| FILED | Wednesday, March 08, 2023 |
| APPL NO | 18/118973 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/60 (20130101) G01R 33/343 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/06 (20130101) Original (OR) Class H01P 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230247853 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanwei Gao (Tallahassee, Florida); Jue Gong (Tallahassee, Florida); Brendon Tyler Jones (Tallahassee, Florida); Moein Adnani (Tallahassee, Florida) |
| ABSTRACT | Methods of encapsulating perovskites, such as metal halide perovskites, that may include depositing a nitride or an oxide on a film that includes a perovskite. Composite materials that include a perovskite layer and a layer of a nitride or an oxide. Devices, such as electronic devices, that include composite materials. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160508 |
| CURRENT CPC | Organic electric solid-state devices H10K 30/88 (20230201) H10K 50/844 (20230201) Original (OR) Class H10K 85/50 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230241591 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pu-Xian Gao (Coventry, Connecticut); Wenxiang Tang (Vemon, Connecticut) |
| ABSTRACT | Manganese-cobalt (Mn—Co) spinel oxide nanowire arrays are synthesized at low pressure and low temperature by a hydrothermal method. The method can include contacting a substrate with a solvent, such as water, that includes Mn04- and Co2 ions at a temperature from about 60° C. to about 120° C. The method preferably includes dissolving potassium permanganate (KMn04) in the solvent to yield the Mn04- ions. the substrate is The nanoarrays are useful for reducing a concentration of an impurity, such as a hydrocarbon, in a gas, such as an emission source. The resulting material with high surface area and high materials utilization efficiency can be directly used for environment and energy applications including emission control systems, air/water purifying systems and lithium-ion batteries. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/166577 |
| CURRENT CPC | Separation B01D 53/864 (20130101) B01D 2255/405 (20130101) B01D 2255/2073 (20130101) B01D 2255/9202 (20130101) B01D 2255/9205 (20130101) B01D 2255/9207 (20130101) B01D 2255/20746 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/005 (20130101) B01J 23/78 (20130101) B01J 23/8892 (20130101) Original (OR) Class B01J 35/04 (20130101) B01J 35/0013 (20130101) B01J 37/0215 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 51/40 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241642 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); William R. Dichtel (Wilmette, Illinois); Nathan P. Bradshaw (Chicago, Illinois); Austin M. Evans (Evanston, Illinois) |
| ABSTRACT | Systems and methods for preparing covalent organic framework (COF) thin films is disclosed herein. The systems and method utilize COF colloidal inks, having a diameter of 10-1000 nm, expelled through a nozzle onto a substrate to prepare the COF thin film. The plurality of COF colloidal ink droplets have an effective deposition diameter from the nozzle onto a masked or unmasked substrate, where the substrate may be heated to an effective COF deposition temperature. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 18/001580 |
| CURRENT CPC | Apparatus for Applying Fluent Materials to Surfaces, in General B05C 5/0295 (20130101) B05C 11/11 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/26 (20130101) Original (OR) Class B05D 1/32 (20130101) B05D 3/0218 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241718 | YOO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Jae Hyuck YOO (Dublin, California); Eyal FEIGENBAUM (Livermore, California) |
| ABSTRACT | The present disclosure relates a method for forming a second material from a first material. The method involves providing a first material having a surface, and irradiating the surface with a heating beam. The surface is also exposed to a flow of reactant while the surface is being heated with the heating beam. This transforms at least a portion of the surface into a second, transformed material different from the first material. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/588795 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/14 (20130101) B23K 26/34 (20130101) B23K 26/083 (20130101) B23K 26/362 (20130101) Original (OR) Class B23K 26/0622 (20151001) B23K 2101/34 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241854 | Hamilton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Samuel James Hamilton (Kansas City, Missouri); Ruben Arturo Pino (Kansas City, Missouri) |
| ABSTRACT | A liner for a ram configured to press a viscous material. The liner includes a liner wall and a circumferential lip. The liner wall is configured to abut a ram plate of the ram and includes a number of apertures configured to align with apertures of the ram plate. The liner wall and circumferential lip are configured to prevent the viscous material from contacting a ram surface and circumferential surface of the ram plate, thus making the ram easier to clean. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/590997 |
| CURRENT CPC | Presses in General B30B 9/3021 (20130101) B30B 15/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242111 | AGGOUNE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DELPHI TECHNOLOGIES IP LIMITED (Belleville, Barbados); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karim AGGOUNE (Auburn Hills, Michigan); Peter M. OLIN (Ann Arbor, Michigan); Daniela TUFANO (Naples, Italy); Shobhit GUPTA (Columbus, Ohio); Shreshta RAJAKUMAR DESHPANDE (Columbus, Ohio); Marcello CANOVA (Columbus, Ohio) |
| ABSTRACT | A method for controlling vehicle energy consumption includes identifying, using a cumulative net energy consumption of a vehicle traversing a route, one or more route segments of the route being traversed by the vehicle. The method also includes determining, for each route segment of the one or more route segments, a vehicle energy consumption profile and determining, for each of the one or more route segments, a profile for a target vehicle speed based on at least one route characteristic and a corresponding vehicle energy consumption profile. The method also includes, for a respective route segment of the one or more route segments generating one or more torque commands based on at least the target vehicle speed profile corresponding to the respective route segment, and selectively controlling, using the one or more torque commands, vehicle propulsion of the vehicle to achieve the target vehicle speed profile. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/589931 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 15/2045 (20130101) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 20/12 (20160101) B60W 30/143 (20130101) Original (OR) Class B60W 2510/244 (20130101) B60W 2520/10 (20130101) B60W 2530/10 (20130101) B60W 2552/15 (20200201) B60W 2555/60 (20200201) B60W 2710/083 (20130101) B60W 2710/0666 (20130101) B60W 2720/10 (20130101) B60W 2720/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242464 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenglong Li (Knoxville, Tennessee); Andrew Sutton (Oak Ridge, Tennessee); Cameron M. Moore (White Rock, New Mexico); Michael Cordon (Knoxville, Tennessee) |
| ABSTRACT | A method for converting a diol in solution to an olefin fraction, the method comprising: (i) reacting a diol of the formula HO—R—OH in solution with a carbonyl-containing molecule of the formula: in the presence of an acid catalyst to result in a dioxolane molecule of the formula: wherein R is a hydrocarbon linker containing 1-12 carbon atoms, and R1 and R2 are independently selected from hydrogen atom and hydrocarbon groups containing 1-12 carbon atoms, wherein R1 and R2 optionally interconnect; (ii) removing the dioxolane molecule from the solution by phase separation; and (iii) contacting the dioxolane molecule with a metal-loaded zeolite at a temperature of 100-500° C. to convert the dioxolane molecule to an olefin fraction. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/104545 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 29/40 (20130101) Acyclic or Carbocyclic Compounds C07C 2/46 (20130101) Original (OR) Class C07C 7/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242825 | Wildfire et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cecilia Energy Inc. (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christina Wildfire (Fairmont, West Virginia); Pranjali Muley (Morgantown, West Virginia); Ashraf Abedin (Morgantown, West Virginia); Kathryn Carpenter (Brooklyn, New York) |
| ABSTRACT | The present disclosure provides methods and apparatuses of producing hydrogen. The methods comprise: (a) contacting a plastic with a catalyst and a gas feed; and (b) applying a microwave at a first temperature. The apparatuses comprise: a reactor for mixing plastic with a catalyst to form a mixture; an inlet for introducing a gas feed; a microwave generator; an optional temperature sensor; and an outlet configured to exhaust the product hydrogen formed in the reactor. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/104116 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/42 (20130101) B01J 8/1809 (20130101) B01J 8/1818 (20130101) B01J 8/1836 (20130101) B01J 2208/00061 (20130101) B01J 2208/00442 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/02 (20130101) Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/463 (20130101) C10J 3/482 (20130101) Original (OR) Class C10J 3/721 (20130101) C10J 2300/123 (20130101) C10J 2300/0946 (20130101) C10J 2300/0986 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242865 | Hazlebeck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Global Algae Technology, LLC (Santee, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Hazlebeck (El Cajon, California); William Rickman (Lebanon, Tennessee) |
| ABSTRACT | Algae harvesting and cultivating systems and methods for producing high concentrations of algae product with minimal energy. In an embodiment, a dead-end filtration system and method includes at least one tank and a plurality hollow fiber membranes positioned in the at least one tank. An algae medium is pulled through the hollow fiber membranes such that a retentate and a permeate are produced. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/133402 |
| CURRENT CPC | Separation B01D 61/22 (20130101) B01D 61/146 (20220801) B01D 63/02 (20130101) B01D 63/04 (20130101) B01D 63/046 (20130101) B01D 65/02 (20130101) B01D 2311/04 (20130101) B01D 2311/06 (20130101) B01D 2311/2626 (20130101) B01D 2311/2688 (20130101) B01D 2313/18 (20130101) B01D 2313/26 (20130101) B01D 2313/50 (20130101) B01D 2315/06 (20130101) B01D 2315/08 (20130101) B01D 2317/02 (20130101) B01D 2317/022 (20130101) B01D 2321/04 (20130101) B01D 2321/18 (20130101) B01D 2321/40 (20130101) B01D 2321/185 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/02 (20130101) C12M 29/04 (20130101) C12M 29/16 (20130101) C12M 29/18 (20130101) C12M 29/20 (20130101) C12M 33/14 (20130101) C12M 41/32 (20130101) C12M 41/44 (20130101) C12M 41/48 (20130101) C12M 45/00 (20130101) C12M 47/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/02 (20130101) C12N 1/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242947 | Bose et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arpita Bose (St. Louis, Missouri); Wei Bai (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Arpita Bose (St. Louis, Missouri); Wei Bai (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of a genetically engineered transgenic microorganisms Rhodopseudomonas palustris and methods of making and using the same. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046695 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) C12N 15/52 (20130101) C12N 15/74 (20130101) C12N 2800/101 (20130101) C12N 2820/002 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/625 (20130101) Original (OR) Class Enzymes C12Y 101/05 (20130101) C12Y 102/01057 (20130101) C12Y 103/01086 (20130101) C12Y 401/01039 (20130101) C12Y 402/01027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242955 | HIMMEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael E. HIMMEL (Littleton, Colorado); Stephen R. DECKER (Berthoud, Colorado); Roman BRUNECKY (Arvada, Colorado); Venkataramanan SUBRAMANIAN (Arvada, Colorado); Brandon Christopher KNOTT (Lakewood, Colorado); Vladimir Vladimirovich LUNIN (Evergreen, Colorado); Todd VANDERWALL (Golden, Colorado) |
| ABSTRACT | A range of Cel7 putative cellobiohydrolase genes were identified using genome mining and homologous sequence alignment to Cel7A from Trichoderma reesei. A representative subset of these genes from across a broad diversity of evolutionarily disparate sources were cloned and expressed in T. reesei using a constitutive promotor and a common secretion signal. The purified recombinant enzymes were tested for efficacy on various substrates. The top performers were subjected to structural studies and subsites likely to confer enhanced performance were predicted using homology modeling and comparisons of natural sequence diversity. Once identified, the subsites were genetically introduced individually and combinatorically into the best in class Cel7A backbone we have found to date and then expressed in T. reesei and tested. A triple mutant was determined to have the highest cellulase activity we have measured in a cellobiohydrolase to date. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/899588 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2437 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) Original (OR) Class Enzymes C12Y 302/01004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243457 | Duncan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Kyle Duncan (Niskayuna, New York); Todd William Danko (Niskayuna, New York) |
| ABSTRACT | A motorized apparatus includes a body assembly and a maintenance device mounted to the body assembly. The maintenance device is configured to perform a service operation on a surface. The maintenance device extends from the body assembly at an angle. The motorized apparatus also includes a plurality of leg assemblies coupled to the body assembly and configured to support the body assembly and the maintenance device at a distance from the surface. The motorized apparatus further includes at least one actuator assembly coupled to the plurality of leg assemblies and configured to independently actuate each leg assembly of the plurality of leg assemblies. The at least one actuator assembly is configured to receive instructions related to a position of the maintenance device and actuate the plurality of leg assemblies to adjust an orientation of the body assembly and the maintenance device relative to the surface. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590556 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 55/18 (20130101) F16L 55/32 (20130101) Original (OR) Class F16L 2101/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243504 | Heher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Transportation IP Holdings, LLC (Norwalk, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett Heher (Pittsburgh, Pennsylvania); Kevin Paul Bailey (Mercer, Pennsylvania); Manuel Licon Flores (Erie, Pennsylvania); Adam Edgar Klingbeil (Ballston Lake, New York); John P. Dowell (Grove City, Pennsylvania) |
| ABSTRACT | An insert device may include a body coupled with an engine cylinder head. The body has an interior surface shaped to receive and engage a distal tip of a fuel injector. The body has gas conduits and mixture conduits with gas conduits extending from inlets along an exterior surface to outlets that intersect the mixture conduits. The mixture conduits extend from inlets along an interior surface of the body to outlets on the exterior surface. The gas conduits are positioned to direct gases outside of the body into the mixture conduits. The mixture conduits are positioned to receive fuel from spray holes of the fuel injector. The mixture conduits can entrain the gas with the fuel into a fuel-and-gas mixture that is directed out of the outlets of the mixture conduits and into a combustion chamber of an engine cylinder. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/122409 |
| CURRENT CPC | Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 53/043 (20130101) F02M 61/168 (20130101) F02M 2700/13 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243648 | Kreitinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bridger Photonics, Inc. (Bozeman, Montana) |
| ASSIGNEE(S) | Bridger Photonics, Inc. (Bozeman, Montana) |
| INVENTOR(S) | Aaron Kreitinger (Bozeman, Montana); Michael James Thorpe (Bozeman, Montana) |
| ABSTRACT | Measurement apparatuses and methods are disclosed for generating high-precision and -accuracy gas concentration maps that can be overlaid with 3D topographic images by rapidly scanning one or several modulated laser beams with a spatially-encoded transmitter over a scene to build-up imagery. Independent measurements of the topographic target distance and path-integrated gas concentration are combined to yield a map of the path-averaged concentration between the sensor and each point in the image. This type of image is particularly useful for finding localized regions of elevated (or anomalous) gas concentration making it ideal for large-area leak detection and quantification applications including: oil and gas pipeline monitoring, chemical processing facility monitoring, and environmental monitoring. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/298898 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 21/20 (20130101) Original (OR) Class Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 15/00 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/28 (20130101) G01M 3/38 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/39 (20130101) G01N 21/53 (20130101) G01N 2021/1793 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 5/00 (20130101) Image or Video Recognition or Understanding G06V 20/64 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243743 | MALLERY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REBELLION PHOTONICS, INC. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan MALLERY (Houston, Texas); Ohad Israel BALILA (Friendswood, Texas); Robert Timothy KESTER (Friendswood, Texas) |
| ABSTRACT | An infrared (IR) imaging system for determining a concentration of a target species in an object is disclosed. The imaging system can include an optical system including a focal plane array (FPA) unit behind an optical window. The optical system can have components defining at least two optical channels thereof, said at least two optical channels being spatially and spectrally different from one another. Each of the at least two optical channels can be positioned to transfer IR radiation incident on the optical system towards the optical FPA. The system can include a processing unit containing a processor that can be configured to acquire multispectral optical data representing said target species from the IR radiation received at the optical FPA. One or more of the optical channels may be used in detecting objects on or near the optical window, to avoid false detections of said target species. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/179879 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/314 (20130101) G01N 21/3504 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243760 | Shugayev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roman Shugayev (Albuquerque, New Mexico); Jagannath Devkota (Pittsburgh, Pennsylvania); Paul R. Ohodnicki, JR. (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method to detect the presence and or concentration of an analyte in the environment of a spoof plasmon sensor having the steps of: providing a spoof plasmon sensor into an environment; interrogating said spoof plasmon sensor with an electromagnetic signal; collecting a modified electromagnetic signal from the spoof plasmon sensor; and analyzing the modified electromagnetic signal to detect an analyte in the environment of the sensor. A spoof plasmon sensor for detecting an analyte having a substrate with a superior surface; and a conductive material disposed on said superior surface, said conductive material defining a waveguide having a dual tapering shape, wherein said waveguide defines spoof plasmon cavities which are exposed substrate, where said substrate is configured to change in permittivity when contacted by an analyte. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/101702 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/00 (20130101) Original (OR) Class G01N 33/0027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243762 | Jimenez, JR. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Steven Jimenez, JR. (Albuquerque, New Mexico) |
| ABSTRACT | A method, apparatus, system, and computer program product for emitting x-rays. A hyperspectral x-ray system comprising a cathode, an anode, and a hyperspectral x-ray detector. The anode comprises a substrate and regions on the substrate. The regions are comprised of materials in which the regions form a pattern on the substrate and x-rays are emitted from the anode in response to an electron beam emitted by the cathode colliding with the anode. The hyperspectral x-ray detector that detects the x-rays. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587272 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/04 (20130101) G01N 23/083 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244530 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tong Chen (Yorktown Heights, New York); John Kevin O'Brien (South Salem, New York); Daniel A. Prener (Croton-On-Hudson, New York); Zehra N. Sura (Yorktown Heights, New York) |
| ABSTRACT | Methods and systems for optimizing an application for a computing system having multiple distinct memory locations that are interconnected by one or more communication channels include determining one or more data handling properties for a data region in an application. One or more data handling policies for the data region are determined based on the one or more data handling properties. Data setup costs are determined for a scope in the application that uses the data region in different memory locations based on the one or more data handling properties. The application is optimized in accordance with the one or more data handling policies and the data setup costs for the different memory locations. |
| FILED | Wednesday, April 05, 2023 |
| APPL NO | 18/296012 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5016 (20130101) Original (OR) Class Climate Change Mitigation Technologies in Information and Communication Technologies [ICT] i.e Information and Communication Technologies Aiming at the Reduction of Their Own Energy Use Y02D 10/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244598 | Roberts |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Roberts (Wellesley, Massachusetts) |
| ABSTRACT | Systems, apparatuses, and methods related to memory access statistics monitoring are described. A host is configured to map pages of memory for applications to a number of memory devices coupled thereto. A first memory device comprises a monitoring component configured to monitor access statistics of pages of memory mapped to the first memory device. A second memory device does not include a monitoring component capable of monitoring access statistics of pages of memory mapped thereto. The host is configured to map a portion of pages of memory for an application to the first memory device in order to obtain access statistics corresponding to the portion of pages of memory upon execution of the application despite there being space available on the second memory device and adjust mappings of the pages of memory for the application based on the obtained access statistics corresponding to the portion of pages. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/591729 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0238 (20130101) Original (OR) Class G06F 12/0292 (20130101) G06F 12/0882 (20130101) G06F 13/1621 (20130101) G06F 13/1689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230246230 | Su et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Chi Cheung Su (Bolingbrook, Illinois); Khalil Amine (Oakbrook, Illinois) |
| ABSTRACT | An electrochemical cell includes a cathode of oxygen or a metal oxide; an anode being made of lithium metal; and an electrolyte including a lithium sulfonylimide salt, a terminally fluorinated glycol ether, and optionally an electrolyte additive, a aprotic gel polymer, or a mixture thereof. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/588740 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/58 (20130101) H01M 4/382 (20130101) H01M 4/525 (20130101) H01M 4/625 (20130101) H01M 10/052 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230246237 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Lu Zhang (Naperville, Illinois); Zhangxing Shi (Chicago, Illinois); Sambasiva R. Bheemireddy (Woodridge, Illinois); Zhou Yu (Bridgeview, Illinois); Lei Cheng (Naperville, Illinois) |
| ABSTRACT | An electrochemical cell includes a cathode including a cathode active material; an anode including silicon, conductive carbon, lithium metal, sodium metal, magnesium metal, sulfur, or a combination of any two or more thereof; a separator; and an electrolyte including a lithium sulfonylimide salt, an asymmetric fluorinated glycol ether, and optionally an electrolyte additive, an aprotic gel polymer, or a mixture thereof. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/588769 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0567 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2300/0034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230246251 | Lopes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Pietro Papa Lopes (Woodridge, Illinois); Timothy Fister (Oak Park, Illinois); Susan J. Babinec (Midland, Michigan); Vojislav Stamenkovic (Naperville, Illinois) |
| ABSTRACT | An electrochemical cell includes a housing, a positive electrode substrate disposed within a first electrode chamber of the housing, a negative electrode substrate disposed within a second electrode chamber of the housing, and a separator may be disposed within the housing between the first electrode chamber and the second electrode chamber. A method further includes pumping a manufacturing electrolyte through the positive electrode portion around the positive electrode substrate. The method further includes applying a first electrical signal to the positive electrode substrate so as to electrochemically fabricate one or both of an active material the negative electrode substrate to form a negative electrode and/or an active material on the positive electrode substrate, thereby forming a positive electrode. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587644 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/44 (20130101) H01M 10/128 (20130101) H01M 10/4242 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230246452 | Chakraborty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Soham Chakraborty (Minneapolis, Minnesota); Sourav Patel (Minneapolis, Minnesota); Murti V. Salapaka (Plymouth, Minnesota) |
| ABSTRACT | A method and system of maintaining electrical power to one or more designated loads connected to an electrical bus that is selectively connected to an electric power grid as a first source of power and to an inverter for providing power to the bus from a second source of electrical power. A controller receives an input indicating if the bus is connected to the grid. The inverter is operated to be synchronized with the grid and provide a selected amount of active and reactive electrical power from the second source of electrical power while the one or more designated loads receive electrical power from the grid. Connection of the bus to the grid is monitored and at the time the electrical bus is no longer receiving power from the grid, the inverter is operated to provide required power without interruption to the one or more designated loads of the bus. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103090 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/40 (20130101) Original (OR) Class H02J 9/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230246969 | ROS GIRALT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Reservoir Labs, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordi ROS GIRALT (Vilafranca del Penedes, Spain); Noah Isaac AMSEL (New York, New York) |
| ABSTRACT | A processor-implemented method includes receiving a network topology describing a network. The method also includes receiving a set of traffic patterns for the network, and a set of network upgrade plans for the network. The method obtains a set of performance parameters from a list of bottleneck structures based on the set of traffic patterns and the network topology, for each upgrade plan. The method then selects a preferred network upgrade plan from the set of network upgrade plans based on the performance parameters. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 17/988687 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/036 (20220501) H04L 45/3065 (20130101) H04L 47/127 (20130101) Original (OR) Class H04L 47/762 (20130101) H04L 47/822 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230247897 | Li |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Li (Tempe, Arizona) |
| ABSTRACT | An organic light emitting diode having a substrate, a first electrode, a hole transporting layer proximate the first electrode, a second electrode, an electron transporting layer proximate the second electrode, and an emissive layer between the hole transporting layer and the electron transporting layer. The emissive layer includes a square planar tetradentate platinum or palladium complex, and excimers formed by two or more of the complexes are aligned such that emitting dipoles of the excimers are substantially parallel to a surface of the substrate. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/167283 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/006 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/02 (20130101) C09K 11/06 (20130101) C09K 2211/185 (20130101) C09K 2211/1007 (20130101) C09K 2211/1014 (20130101) C09K 2211/1022 (20130101) C09K 2211/1029 (20130101) C09K 2211/1044 (20130101) Organic electric solid-state devices H10K 50/11 (20230201) H10K 85/341 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230247911 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia Li (Providence, Rhode Island); Andrew Mounce (Albuquergue, New Mexico); Erin Morissette (Providence, Rhode Island); Jiangxiazi Lin (Providence, Rhode Island) |
| ABSTRACT | Systems and methods are provided for fabricating an assembly with a controllable magnetic state and ferromagnetic resonance. A layer of twisted bilayer graphene is positioned in contact with a transition metal dichalcogenide to form a structure with an interface between the twisted bilayer graphene and the transition metal dichalcogenide. Energy is applied to the interface to adjust one of a magnetic state associated with the interface and a ferromagnetic resonance associated with the interface |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103290 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/16 (20130101) H01P 11/006 (20130101) Electronic Memory Devices H10B 61/10 (20230201) Electric solid-state devices not otherwise provided for H10N 50/01 (20230201) Original (OR) Class H10N 50/85 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230241054 | Jenkins |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Elysium Therapeutics, Inc. (Akron, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas E. Jenkins (Half Moon Bay, California) |
| ABSTRACT | The invention provides compositions and methods for the treatment or prevention of pain. The invention provides constructs whereby hydrolysis of the construct by a specified gastrointestinal enzyme directly, or indirectly, releases an opioid when taken orally as prescribed. The gastrointestinal enzyme mediated release of opioid from constructs of the invention is designed to be attenuated in vivo via a saturation or inhibition mechanism when overdoses are ingested. The invention further provides constructs that are highly resistant to oral overdose, chemical tampering, and abuse via non-oral routes of administration. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884305 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) Original (OR) Class A61K 47/55 (20170801) A61K 47/61 (20170801) A61K 47/64 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244074 | Gao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Magic Leap, Inc. (Plantation, Florida) |
| ASSIGNEE(S) | Magic Leap, Inc. (Plantation, Florida) |
| INVENTOR(S) | Chunyu Gao (Tucson, Arizona); Yuxiang Lin (Tucson, Arizona); Hong Hua (Tucson, Arizona) |
| ABSTRACT | The present invention comprises a compact optical see-through head-mounted display capable of combining, a see-through image path with a virtual image path such that the opaqueness of the see-through image path can be modulated and the virtual image occludes parts of the see-through image and vice versa. |
| FILED | Tuesday, April 04, 2023 |
| APPL NO | 18/295685 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 13/06 (20130101) G02B 25/001 (20130101) G02B 26/00 (20130101) Original (OR) Class G02B 27/144 (20130101) G02B 27/0172 (20130101) G02B 27/283 (20130101) G02B 27/1066 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 37/02 (20130101) Image Data Processing or Generation, in General G06T 19/006 (20130101) Pictorial Communication, e.g Television H04N 23/45 (20230101) H04N 23/698 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245388 | Young et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRX Systems, Inc. (Greenbelt, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis Young (Rockville, Maryland); Daniel Hakim (Silver Spring, Maryland); Daniel Franchy (Catonsville, Maryland); Jared Napora (Severn, Maryland); John Karvounis (Bowie, Maryland); Jonathan Fetter Degges (Washington, District of Columbia); Tim Wang (Germantown, Maryland); Benjamin Funk (Hanover, Maryland); Carole Teolis (Glendale, Maryland); Carol Politi (Bethesda, Maryland); Stuart Woodbury (Ellicott City, Maryland) |
| ABSTRACT | Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880530 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3867 (20200801) Electric Digital Data Processing G06F 30/13 (20200101) Image Data Processing or Generation, in General G06T 17/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230246229 | BOLTON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Octet Scientific, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Onas James BOLTON (Pepper Pike, Ohio); Emily Janine DICKENS (Cleveland, Ohio); Mark Richard RUBINO (Holland, Michigan) |
| ABSTRACT | Provided herein are novel organic sulfonic acid or sulfonate zinc-battery electrolyte additive chemicals with surprising advantageous properties such as, but not limited to, stability and the ability to facilitate zinc plating while limiting the formation of zinc dendrites. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/157700 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0563 (20130101) Original (OR) Class H01M 2300/0005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230240270 | Tillman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Anthony Tillman (Gainesville, Florida) |
| ABSTRACT | The species-selective bird feeder is a bird feeder with a feeding tray that is selectively coverable to only provide access thereto by particular bird species. The species-selective bird feeder includes a support, a feeding tray mounted on an upper end of the support, and a bird feed dispensing hopper supported on the feeding tray. An additional cage is provided for selectively covering the feeding tray. The cage includes at least one sidewall and an open lower end. The cage is vertically adjustable with respect to the support and the feeding tray, such that, in a raised position of the cage, the feeding tray is freely accessible to birds and, in a lowered position, the feeding tray is only accessible through the open lower end of the cage. In the lowered position, the open lower end of the cage is positioned beneath the feeding tray. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/101160 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 39/01 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230241074 | TANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF CONNECTICUT (Farmington, Connecticut); ATOMWISE INC. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Young TANG (Storrs, Connecticut); Antonio E. GARMENDIA (Storrs, Connecticut); Chang HUANG (Storrs, Connecticut); Denzil BERNARD (San Francisco, California) |
| ABSTRACT | Disclosed herein are compositions comprising a compound of Formula (I) and methods for treating or prophylaxis of porcine reproductive and respiratory syndrome (PRRS) therewith (I). |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/999275 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/498 (20130101) A61K 31/5377 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242963 | Dinovo |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Guild Associates Inc. (Dublin, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Augustine Dinovo (Charleston, South Carolina) |
| ABSTRACT | Current methods for detection of microbial contaminants on surfaces use swabbing/wiping to extract microbes for analysis. This removes easily transferable microbes but fails to extract microbes living in biofilms, which reduces sensitivity and may mask the true degree of contamination. The current disclosure provides an enzyme cocktail that disrupts the biofilm and improves the extraction of live microbes for analysis. Applicant's enzyme system is particularly useful for the application to a variety of surfaces, but particularly on a variety of food processing surfaces. Utilization of Applicant's enzyme cocktail makes possible the extraction of a representative sample of live microorganisms present on a surface, including film forming microorganisms, without affecting non-film forming microorganisms also present on a surface. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/163862 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/2414 (20130101) C12N 9/2454 (20130101) C12N 9/6424 (20130101) C12N 9/6427 (20130101) C12N 9/6472 (20130101) C12N 9/6491 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/10 (20130101) C12Q 1/24 (20130101) Original (OR) Class Enzymes C12Y 302/01001 (20130101) C12Y 302/01011 (20130101) C12Y 304/21004 (20130101) C12Y 304/21062 (20130101) C12Y 304/22002 (20130101) C12Y 304/24007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230240601 | Ahlers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Naval Medical Research Center (Silver Spring, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the secretary of the Navy (Silver Spring, Maryland) |
| INVENTOR(S) | Stephen T. Ahlers (Olney, Maryland); Anna E. Tschiffely (Walkersville, Maryland) |
| ABSTRACT | This invention discloses a method for improving behavioral deficits and lowering brain Aβ42 in subjects at risk for or in early stage of Alzheimer's disease or other neurodegenerative diseases by exposing said subject to frequent repetitive low intensity blast overpressure. The invention also discloses a method for treating and preventing Alzheimer's disease or other neurodegenerative diseases and associated conditions by reduce abnormal accumulation of brain protein, improve brain inflammation and clearance of amyloid beta. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/105059 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4064 (20130101) A61B 5/4884 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242628 | Sajadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); U.S. Department of Veterans Affairs (Washington, District of Columbia); The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Sajadi (Cockeysville, Maryland); Paolo Lusso (Rockville, Maryland); Qingbo Liu (Rockville, Maryland) |
| ABSTRACT | The present invention provides broadly neutralizing and potent antibodies against HIV, compositions comprising the same and methods of use thereof. |
| FILED | Friday, November 27, 2020 |
| APPL NO | 17/778536 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1063 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230242903 | DAVE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Utpal DAVE (Nashville, Tennessee); Justin LAYER (Indianapolis, Indiana) |
| ABSTRACT | A system for multiplex expression of proteins in eukaryotic cells is provided wherein cells simultaneously expressing each of the proteins of the system in a cell can be selected and/or visualized. The system comprises a plurality of lentiviral based vectors that each allow for the expression of the protein of interest, and a fluorescent protein linked to a fusion peptide comprising a proteolytic cleavage site that itself is linked to an antibiotic resistance protein. Each of the vectors of the system has a separate and unique fluorescent protein encoding gene and/or a separate and unique antibiotic resistance gene. |
| FILED | Wednesday, September 18, 2019 |
| APPL NO | 17/276213 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/65 (20130101) C12N 15/86 (20130101) C12N 15/1058 (20130101) Original (OR) Class C12N 15/1065 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230242704 | Hinkley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. Hinkley (Yorktown, Virginia); Jin Ho Kang (Newport News, Virginia); Keith L. Gordon (Hampton, Virginia); Sheila A. Thibeault (Hampton, Virginia) |
| ABSTRACT | Various embodiments may include low-creep and low-stress-relaxation polymer composites (or reduced-creep and reduced-stress-relaxation polymer composites) and methods for making low-creep and low-stress-relaxation polymer composites (or reduced-creep and reduced-stress-relaxation polymer composites). Various embodiments may include a polymeric material, comprising: a tetrafunctional epoxy in an epoxy weight amount; an amine hardener in a hardener weight amount, wherein a weight ratio of the epoxy weight amount to the hardener weight amount is 1:0.38 or greater; and an oligomer additive in an additive concentration, the oligomer additive comprising a monomer combined with 4′-hydroxyacetanilide (HAA). |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589403 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/504 (20130101) C08G 59/3227 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245444 | Brockers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Roland Brockers (Pasadena, California); Pedro Duarte Lopes Mascarenhas Proença (Pasadena, California); Pascal Schoppmann (Pasadena, California); Matthias Domnik (Pasadena, California); Jeff H. Delaune (Pasadena, California) |
| ABSTRACT | A method, system, and apparatus for an unmanned aerial vehicle (UAV) to autonomously reconstruct overflown terrain and detect safe landing sites. A UAV autonomously acquires on-board pose estimates from an on-board visual-inertial-range odometry method during flight. The on-board pose estimates are utilized as a pose prior and to regain metric scale during three-dimensional (3D) reconstruction. The on-board pose estimates are corrected based on a bundle adjustment approach using previously acquired images. 3D reconstruction is performed based on multiple captured images taken from an on-board camera. Range data from the multiple captured images is fused into a multi-resolution height map. A safe landing site on the terrain is detected based on the multi-resolution height map. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/740101 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/123 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 45/04 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/47 (20130101) G01S 19/485 (20200501) Image Data Processing or Generation, in General G06T 15/00 (20130101) G06T 17/05 (20130101) G06T 2200/08 (20130101) G06T 2210/36 (20130101) Image or Video Recognition or Understanding G06V 10/803 (20220101) G06V 20/17 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230245049 | TARTAL |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES POSTAL SERVICE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William A. TARTAL (Baltimore, Maryland) |
| ABSTRACT | A system for and method of providing a package for retrieval are presented. The disclosed techniques include receiving a package for retrieval by a recipient; placing the package in a customer inaccessible smart staging area; determining, using a sensor, a size of the package; retrieving, by a robot, the package; conveying, by the robot, the package through a first side of the customer accessible repository to a customer accessible repository selected according to the size of the package, where the package is retrievable by a customer through a second side of the customer accessible repository; electronically storing an identification of the customer accessible repository in association with package identification information; receiving, at an electronic customer interface located at the delivery facility, the package identification information; and unlocking the customer accessible repository, such that the package is retrievable from the second side of the customer accessible repository by the recipient. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154381 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0836 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245516 | Hanlon |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Sean Hanlon (Orchard Park, New York) |
| ABSTRACT | Systems and methods to deliver items to smart receptacles or locations secured by smart locks. A distribution network can provide access codes or credentials to access smart locks. Access codes or credentials can be provided when a mobile delivery device is determined to be within a geofence of the delivery point and/or when the mobile delivery device meets specified security criteria. |
| FILED | Monday, April 10, 2023 |
| APPL NO | 18/297839 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 9/21 (20200101) Original (OR) Class Wireless Communication Networks H04W 4/021 (20130101) H04W 4/029 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20230245388 | Young et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRX Systems, Inc. (Greenbelt, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis Young (Rockville, Maryland); Daniel Hakim (Silver Spring, Maryland); Daniel Franchy (Catonsville, Maryland); Jared Napora (Severn, Maryland); John Karvounis (Bowie, Maryland); Jonathan Fetter Degges (Washington, District of Columbia); Tim Wang (Germantown, Maryland); Benjamin Funk (Hanover, Maryland); Carole Teolis (Glendale, Maryland); Carol Politi (Bethesda, Maryland); Stuart Woodbury (Ellicott City, Maryland) |
| ABSTRACT | Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880530 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3867 (20200801) Electric Digital Data Processing G06F 30/13 (20200101) Image Data Processing or Generation, in General G06T 17/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20230242418 | YIP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Ngai Yin YIP (Summit, New Jersey); Chanhee BOO (Seoul, South Korea); Kinnari SHAH (New York, New York); Ian BILLINGE (New York, New York); Robert WINTON (Seattle, Washington); Eliza DACH (New York, New York) |
| ABSTRACT | Systems and methods of performing temperature swing solvent extraction (TSSE) descaling of produced water and desalination of high-salinity brines, e.g., those having a total dissolved solids (TDS) greater than about 250,000 ppm are capable of producing descaled water products including less than about 5% weight percent TDS. The brine/produced water feedstreams and combined with a solvent having temperature-dependent water solubility at a temperature TL. Water is extracted from the feedstream into the solvent to form a water-in-solvent extract component and a raffinate component, from which a solid phase can be precipitated as more water is portioned in the solvent and basicity increases. Heating of the water-in-solvent extract component reduces the solubility of the water therein, producing a biphasic mixture of dewatered solvent and descaled water that can be separated. Because these systems and methods do not require a phase change of water, these products are achieved with significantly higher energy efficiencies when compared to evaporation-based thermal methods. |
| FILED | Thursday, April 06, 2023 |
| APPL NO | 18/131444 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/042 (20130101) C02F 1/66 (20130101) C02F 1/265 (20130101) Original (OR) Class C02F 1/444 (20130101) C02F 2103/10 (20130101) C02F 2209/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Smithsonian Institution (SI)
| US 20230242482 | Luesch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Smithsonian Institution (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Smithsonian Institution (Washington, District of Columbia) |
| INVENTOR(S) | Hendrik Luesch (Gainesville, Florida); Xiao Liang (Gainesville, Florida); Susan Matthew (Houston, Texas); Jason C. Kwan (Gainesville, Florida); Qi-Yin Chen (Gainesville, Florida); Valerie J. Paul (Fort Pierce, Florida) |
| ABSTRACT | The invention is directed towards compounds (e.g., Formulae (I)-(IX)), their mechanism of action, processes to prepare the compounds, methods of activating quorum sensing signaling activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formulae (I)-(IX)). |
| FILED | Friday, July 24, 2020 |
| APPL NO | 17/630138 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230242586 | Shokat et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The University of Tokyo (Tokyo, Japan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevan M. Shokat (San Francisco, California); Hiroaki Suga (Tokyo, Japan); Ziyang Zhang (San Francisco, California); Rong Gao (Shanghai, China PRC) |
| ABSTRACT | Described herein, inter alia, are Ras inhibitors and uses thereof. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/919895 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230243704 | Knobloch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Jay Knobloch (Niskayuna, New York); Adam Halverson (Albany, New York) |
| ABSTRACT | Systems and methods disclosed herein use a multi-color pyrometer configured to determine a first temperature in a high temperature range and a single-color pyrometer configured to determine second temperature in a low temperature range. The system uses information gained from determination of the first temperature in the high temperature range to facilitate later determining the second temperature in the low temperature range. The first temperature in the high temperature range and the second temperature in the low temperature range are used to monitor and control different engine operations that occur at different times. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/588917 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/12 (20130101) G01J 5/026 (20130101) Original (OR) Class G01J 5/0088 (20130101) G01J 5/0806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230244007 | Starkovich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northrop Grumman Systems Corporation (Falls Church, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Starkovich (Redondo Beach, California); Edward M. Silverman (Redondo Beach, California) |
| ABSTRACT | A method using capillary force lamination (CFL) for manufacturing a high-performance optical absorber, includes: texturizing a base layer of the high-performance optical absorber, the base layer comprising one or more of a polymer film and a polymer coating; joining a surface layer of the high-performance optical absorber to the base layer, the surface layer comprising a non-woven carbon nanotube (CNT) sheet; wetting the joined surface layer and base layer with a solvent; drying the joined surface layer and base layer; and treating the resulting base layer with plasma, creating the high-performance optical absorber. |
| FILED | Thursday, March 23, 2023 |
| APPL NO | 18/125204 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/0074 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Optical Elements, Systems, or Apparatus G02B 5/003 (20130101) Original (OR) Class G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230245447 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zhaocheng Wang (Mesa, Arizona); Enrique Vivoni (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhaocheng Wang (Mesa, Arizona); Enrique Vivoni (Tempe, Arizona) |
| ABSTRACT | Systems and methods for determining varying phenomena in an environment. In an embodiment, an system includes a processor configured to receive a sequence of remote sensing data regarding an environment, wherein the environment comprises a target area where changes have occurred and a surrounding area where few or no changes have occurred; process the RS data to determine signals for the changes that have occurred in the target area and where no changes have occurred in the surrounding area, wherein the signals comprise reflected sunlight radiation or returned light or radiation of different wavelengths captured by the sensor; process the signals to determining environment data indicting varying phenomena in the environment, wherein the varying phenomena in the environment comprise changes in the physical characteristics of the target area and an amount of radiation captured by the RS data; and provide the environment data for display via a user device. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/163077 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/002 (20130101) Image or Video Recognition or Understanding G06V 10/75 (20220101) G06V 10/762 (20220101) G06V 20/13 (20220101) G06V 20/182 (20220101) G06V 20/194 (20220101) Original (OR) Class Pictorial Communication, e.g Television H04N 7/181 (20130101) H04N 23/11 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, August 03, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230803.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page