FedInvent™ Patent Applications
Application Details for Thursday, August 31, 2023
This page was updated on Friday, September 01, 2023 at 09:25 AM GMT
Department of Health and Human Services (HHS)
| US 20230270103 | Sevenler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derin Sevenler (Cambridge, Massachusetts); Rebecca Sandlin (Melrose, Massachusetts); Mehmet Toner (Charlestown, Massachusetts) |
| ABSTRACT | Hydrogel beads having tunable rates of loading and unloading of cryoprotective agents are provided herein. Such hydrogel beads can be dispersed throughout a cell suspension to enable loading and unloading of cryoprotective agents from cells in a gradual and distributed manner that protects the cells from osmotic damage. Lymphocyte viability after cryopreservation is significantly greater when cryoprotective agents are loaded and unloaded using hydrogel beads compared to conventional media exchange methods. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 18/016101 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) A01N 1/0284 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2533/74 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270333 | Ben-Yakar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adela Ben-Yakar (Austin, Texas); Kaushik Subramanian (Austin, Texas); Ilan Gabay (Austin, Texas); Liam Andrus (Austin, Texas); Berk Camli (Austin, Texas) |
| ABSTRACT | Imaging components and systems are described herein. An example imaging component can include: a housing; at least one excitation optical element at least partially disposed within the housing; at least one laser-guiding element at least partially disposed within the housing, the at least one laser-guiding element being configured to deliver excitation pulses to a target location through the at least one excitation optical element via an aperture; and a signal collecting element disposed adjacent to the at least one excitation optical element. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/158237 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00096 (20130101) A61B 5/0062 (20130101) Original (OR) Class A61B 5/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270343 | MUKKAMALA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); University of Maryland (College Park, Maryland) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); University of Maryland (College Park, Maryland) |
| INVENTOR(S) | Ramakrishna MUKKAMALA (Okemos, Michigan); Mohammad YAVARIMANESH (Lansing, Michigan); Jin-Oh HAHN (Rockville, Maryland) |
| ABSTRACT | An aortic aneurysm carries increasing risk of rupture with growing aneurysm diameter. This condition is typically asymptomatic, so screening and surveillance are essential. Ultrasound and other imaging methods are employed for such monitoring at high accuracy. However, these methods require an expert and are expensive. Aortic aneurysms are considerably under-detected at present and may become even more under-detected in the future as the disease prevalence increases with societal aging. This disclosure present devices that are convenient in use and cost for aortic aneurysm screening and surveillance. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 18/016533 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0295 (20130101) A61B 5/6898 (20130101) A61B 5/7264 (20130101) A61B 5/7282 (20130101) Original (OR) Class A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270352 | Zelik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl Zelik (Nashville, Tennessee); Emily Matijevich (Nashville, Tennessee); Peter Volgyesi (Nashville, Tennessee) |
| ABSTRACT | A wearable device operably worn by a user for monitoring musculoskeletal loading on a back segment of the user includes a plurality of sensors that is synchronized to each other, each sensor operably attached at a predetermined location of the user and configured to detect information about a biomechanical activity of the musculoskeletal systems, wherein the plurality of sensors comprises at least one motion/orientation sensor; and a processing unit in communication with the plurality of sensors and configured to process the detected information by the plurality of sensors to estimate the musculoskeletal loading and/or damage and/or injury risk, and communicate the estimated musculoskeletal loading and/or damage and/or injury risk to the user and/or a party of interest. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 18/017877 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/11 (20130101) Original (OR) Class A61B 5/296 (20210101) A61B 5/746 (20130101) A61B 5/4509 (20130101) A61B 5/4538 (20130101) A61B 5/4806 (20130101) A61B 5/6801 (20130101) A61B 5/6898 (20130101) A61B 5/7405 (20130101) A61B 5/7435 (20130101) A61B 5/7455 (20130101) A61B 2562/0219 (20130101) A61B 2562/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270403 | Egorov |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vladimir Egorov (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Egorov (Princeton, New Jersey) |
| ABSTRACT | A cervical probe, outfitted with a tactile sensor array and an ultrasound transducer, is designed for simultaneous collection of stress and ultrasound strain data from the same cervical sector. The gathered stress and strain data from multiple cervical sectors are sent to a data processor, which calculates cervical elasticity as a strain-to-stress ratio. Subsequently, an average stress-to-strain ratio is compared to a predetermined cutoff value to predict preterm birth at 24-28 gestational weeks. |
| FILED | Monday, May 08, 2023 |
| APPL NO | 18/144752 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/12 (20130101) A61B 8/54 (20130101) A61B 8/485 (20130101) A61B 8/0866 (20130101) Original (OR) Class Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/067 (20130101) B06B 2201/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270497 | Zharov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BioVentures, LLC (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Pavlovich Zharov (Little Rock, Arkansas); Ekaterina Galanzha (Little Rock, Arkansas) |
| ABSTRACT | A device and method of using the device to detect the presence and composition of clots and other target objects in a circulatory vessel of a living subject is described. In particular, devices and methods of detecting the presence and composition of clots and other target objects in a circulatory vessel of a living subject using in vivo photoacoustic flow cytometry techniques is described. |
| FILED | Friday, February 03, 2023 |
| APPL NO | 18/105636 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/0095 (20130101) A61B 5/412 (20130101) A61B 5/415 (20130101) A61B 5/416 (20130101) A61B 5/418 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/1495 (20130101) A61B 5/02007 (20130101) A61B 5/4839 (20130101) A61B 5/7282 (20130101) A61B 5/7405 (20130101) A61B 5/7455 (20130101) A61B 5/14535 (20130101) A61B 8/06 (20130101) A61B 8/08 (20130101) A61B 8/481 (20130101) A61B 18/245 (20130101) Original (OR) Class A61B 18/1815 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/22 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/30 (20130101) B03C 1/288 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/1702 (20130101) G01N 29/2418 (20130101) G01N 29/4427 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270599 | Xie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingwei Xie (Omaha, Nebraska); Mark Carlson (Omaha, Nebraska); Shixuan Chen (Omaha, Nebraska); Alec McCarthy (Omaha, Nebraska) |
| ABSTRACT | Nanofiber swabs are provided as well as methods of use thereof and methods of making. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/096682 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0051 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/385 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/32 (20130101) A61L 15/40 (20130101) A61L 15/60 (20130101) A61L 2400/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270673 | Venditto et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent J. Venditto (Lexington, Kentucky); Ahmed Abdel-Latif (Lexington, Kentucky); Ahmed Al-Darraji (Lexington, Kentucky); Dave Feola (Lexington, Kentucky); John C. Gensel (Versailles, Kentucky) |
| ABSTRACT | A composition and method for treating a subject following myocardial infarction are provided. The composition includes a non-PEGylated liposome. The method includes administering a non-PEGylated liposome to a subject in need thereof following myocardial infarction. |
| FILED | Tuesday, April 18, 2023 |
| APPL NO | 18/136298 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 31/7048 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270677 | Ho |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Rodney J.Y. Ho (Seattle, Washington) |
| ABSTRACT | The present disclosure describes simple, stable, and scalable antiviral therapeutic agent compositions that transform short-acting antiviral (e.g., anti-HIV) therapeutic agents that would otherwise require daily short-acting oral administration into long-acting injectable forms that lasts for many weeks per administration. A mixture of water-soluble and water-insoluble antiviral therapeutic agents can be present in the long-acting and drug-combination composition. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/791504 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1617 (20130101) Original (OR) Class A61K 31/52 (20130101) A61K 31/426 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/536 (20130101) A61K 31/4985 (20130101) A61K 31/7076 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270691 | Gelfand et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advent Therapeutics, Inc. (Lumberville, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig Alan Gelfand (Hancock, New Hampshire); Robert Segal (Gwynedd Valley, Pennsylvania); David Lawrence Lopez (Lumberville, Pennsylvania) |
| ABSTRACT | The present disclosure relates to pharmaceutical compositions suitable for inhalation, parenteral administration, and oral administration comprising a an insoluble active ingredient, pharmaceutical systems comprising them, methods of treatment and/or prophylaxis, and uses comprising them. The formulations, systems, and compositions provided by the present disclosure may be used and are useful in the treatment and/or prophylaxis of vitamin deficiency disorders (including but not limited to nutritional insufficiency, premature birth, genetic defect, or induced pursuant to infection or disease states), hyperoxia damage, oxidative lung injury (lung damage), lung damage caused by chemical or environmental exposure, lung damage caused by a biological/infectious agent, including but not limited to bacterial infections and/or viral infections, lung damage caused by a chemical, biological, or radio-nuclear (CBRN) agent, and lung damage caused by radio-nuclear exposure, including but not limited to acute radiation- induced lung injury/damage and/or chronic lung injury/damage, including but not limited to delayed effects of acute radiations exposure (DEARS). |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 18/007589 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0078 (20130101) A61K 31/07 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 39/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270732 | MAJETSCHAK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias MAJETSCHAK (Tampa, Florida); Anthony DESANTIS (Tampa, Florida); Xianlong GAO (Tampa, Florida) |
| ABSTRACT | CCR2 is involved in the regulation of normal cardiovascular function and during the cardiovascular stress response to hemorrhagic shock and fluid resuscitation. Disclosed herein are methods of using CCR2 inhibitors to reduce fluid requirements and to prevent death from hemodynamic decompensation during resuscitation. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/115058 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/4439 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270739 | Siegel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The United States Government as Represented by the Department of Veterans Affairs (810 Vermont Ave., NW, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerome Siegel (Porter Ranch, California); Ronald McGregor (Sherman Oaks, California); Ming-Fung Frank Wu (Porter Ranch, California) |
| ABSTRACT | Disclosed herein are compositions and methods for treating subjects for pain with opioids while reducing or inhibiting their risk of opioid addiction. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/925775 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/485 (20130101) Original (OR) Class A61K 31/5513 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270749 | Kohane et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Daniel S. Kohane (Newton, Massachusetts); Zipei Zhang (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions and methods for delivery of therapeutic agents across a barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic), a permeation enhancer comprising sodium dodecyl sulfate, limonene, and/or bupivacaine which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent that is a poloxamer (e.g., poloxamer P188), wherein the composition comprises: between about 0.2% and 3.2% wt/vol of a permeation enhancer that is sodium dodecyl sulfate; when present, between about 0.2% and 2.0% wt/vol of a permeation enhancer that is bupivacaine; between about 0.5% and 7.0% wt/vol of a permeation enhancer that is limonene; between approximately 18-62% P188; and the composition forms a gel at temperatures above a phase transition temperature that is less than about 37° C. The matrix forming agent forms a gel at a suitable gelation temperature and rheological properties for use in drug delivery. Methods of treatment and/or delivery, uses, and kits for the compositions described herein are also provided. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 18/019302 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 31/496 (20130101) A61K 31/546 (20130101) Original (OR) Class A61K 47/06 (20130101) A61K 47/10 (20130101) A61K 47/20 (20130101) A61K 47/22 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270753 | Gallagher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AGENEBIO, INC. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michela Gallagher (Baltimore, Maryland); Sharon Rosenzweig-Lipson (East Brunswick, New Jersey) |
| ABSTRACT | This disclosure relates to methods, uses, combinations, pharmaceutical compositions, combinations for use, and pharmaceutical compositions for use useful for treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), in combination with GABAA α5 receptor agonists, in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, mild cognitive impairment (MCI), amnestic MCI (aMCI), age-associated memory impairment (AAMI), age related cognitive decline (ARCD), dementia, Alzheimer's disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism, compulsive behavior, and substance addiction. Further, the disclosure relates to methods, uses, combinations, pharmaceutical compositions, combinations for use, and pharmaceutical compositions for use useful for treating cognitive impairment associated with brain cancer or for treating brain cancer itself in a subject in need thereof. Additionally, the disclosure relates to methods, uses, combinations, pharmaceutical compositions, combinations for use, and pharmaceutical compositions for use useful for treating Parkinson's disease psychosis in a subject in need thereof. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 18/015439 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/4015 (20130101) A61K 31/5517 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270776 | Neuwelt |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Edward A. Neuwelt (Portland, Oregon) |
| ABSTRACT | Described herein is a method for eliminating or reducing ototoxicity in patients receiving a platinum based chemotherapeutic. In particular, are methods of reducing ototoxicity in a pediatric patient. The methods described herein include administering an effective amount of sodium thiosulfate to a patient in need thereof to reduce ototoxicity. |
| FILED | Tuesday, May 09, 2023 |
| APPL NO | 18/195296 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/04 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270795 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California); Technion Research and Development Foundation Ltd. (Haifa, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Li (La Jolla, California); Scott Peterson (La Jolla, California); Linda Bradley (La Jolla, California); Roberto Tinoco (La Jolla, California); Ze`ev Ronai (San Diego, California); Shiri Ashkenazi (Haifa, Israel) |
| ABSTRACT | The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103166 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/733 (20130101) A61K 31/7004 (20130101) A61K 31/7008 (20130101) A61K 31/7024 (20130101) A61K 35/74 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270818 | Goldman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Steven A. Goldman (Webster, New York); Abdellatif Benriass (Pittsford, New York); John Mariani (Rochester, New York) |
| ABSTRACT | The present application relates to a method of treating a subject having a condition mediated by a deficiency in myelin. This method involves selecting a subject having a condition mediated by a deficiency in myelin and expressing a transcription factor 7-like 2 (TCF7L2) protein in the selected subject under conditions effective to treat the condition. Also disclosed is a method of increasing oligodendrocyte production from glial progenitor cells. This method involves providing a population of glial progenitor cells and expressing a TCF7L2 protein in the provided population of glial progenitor cells under conditions effective to increase oligodendrocyte production compared to oligodendrocyte production absent said administering. Also disclosed is a genetic construct suitable, inter alia, for carrying out these methods. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 18/051653 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 48/0058 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) C12N 2506/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270831 | Brenner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Malcolm K. Brenner (Bellaire, Texas); Jack James (Wilmington, North Carolina) |
| ABSTRACT | Provided herein are methods for cell therapy by modifying transfused cells to express an inducible caspase 9 protein, so that the cells may be selectively killed if the patient experiences dangerous side effects. Provided also within relates in part to methods for preventing or treating Graft versus Host Disease by modifying T cells before administration to a patient, so that they may be selectively killed if GvHD develops in the patient. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/934501 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/28 (20130101) A61K 35/545 (20130101) A61K 38/52 (20130101) Original (OR) Class A61K 38/4873 (20130101) A61K 39/001 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Peptides C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0663 (20130101) C12N 2501/48 (20130101) C12N 2510/00 (20130101) Enzymes C12Y 304/22062 (20130101) C12Y 502/01008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270833 | Kew et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the USA as represented by the Secretary of the Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The Government of the USA as represented by the Secretary of the Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Olen M. Kew (Alpharetta, Georgia); Cara Carthel Burns (Avondale Estates, Georgia); Jing Shaw (Decatur, Georgia); Raymond Campagnoli (Decatur, Georgia); Jacqueline Quay (Chapel Hill, North Carolina) |
| ABSTRACT | Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 18/047395 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/0258 (20130101) Original (OR) Class A61K 2039/522 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/245 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/67 (20130101) C12N 2710/16162 (20130101) C12N 2710/16662 (20130101) C12N 2710/16762 (20130101) C12N 2760/16162 (20130101) C12N 2760/18462 (20130101) C12N 2760/18562 (20130101) C12N 2770/20062 (20130101) C12N 2770/24162 (20130101) C12N 2770/32162 (20130101) C12N 2770/32762 (20130101) C12N 2770/36262 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270842 | Schrader et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VAXESS TECHNOLOGIES, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | VAXESS TECHNOLOGIES, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael A. Schrader (Watertown, Massachusetts); Kathryn M. Kosuda (Cambridge, Massachusetts); Jonathan A. Kluge (Cambridge, Massachusetts); Kimberly M. Cirelli (Brookline, Massachusetts); Emily L. Borkowski (Somerville, Massachusetts); Cassie L. Caudill (Watertown, Massachusetts); Matthew Dirckx (Medford, Massachusetts); Nickolas W. Hartman (Houston, Texas); Livio Valenti (Cambridge, Massachusetts) |
| ABSTRACT | Microneedle and microneedle devices including implantable tips (e.g., silk-based tips) for sustained dermal delivery of a coronavirus and/or influenza vaccine, kits, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for controlled- or sustained-administration of a coronavirus vaccine and/or an influenza vaccine to provide improved immunogenicity and/or broad-spectrum immunity to a subject are also described. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991525 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) A61K 39/145 (20130101) A61K 39/215 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270845 | Varadarajan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| INVENTOR(S) | Navin Varadarajan (Houston, Texas); Xinli Liu (Houston, Texas) |
| ABSTRACT | Described herein are compositions and methods for the prevention of pathogens such as conditions in an animal (e.g., a subject). In some cases, a composition or method described herein can comprise a liposome, which may be used to encapsulate one or more STING agonists. In some cases, a liposome of a composition or method described herein may comprise one or more antigens attached to, integrated into, or associated with a liposomal membrane of the liposome. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 18/017659 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270853 | VERMEER |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SANFORD HEALTH (Sioux Falls, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paola VERMEER (Sioux Falls, South Dakota) |
| ABSTRACT | Disclosed herein are compositions and methods for tumor treatment involving administering to a subject having a tumor with an amount effective to limit tumor growth or metastasis of an ephrin B1 inhibitor, or a pharmaceutically acceptable salt thereof; and/or an inhibitor of tumor exosomal release, or a pharmaceutically acceptable salt thereof |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/818907 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 39/39558 (20130101) Original (OR) Class Peptides C07K 16/28 (20130101) C07K 16/40 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270855 | Lin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State of University New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Lin (East Setauket, New York) |
| ABSTRACT | The present invention relates to the field of cancer biology and immunology. More specifically, the present invention relates to the use of genetically modified immune cells in combination with certain chemotherapeutic agents for the treatment of cancer, wherein the genetically modified immune cells are resistant to said chemotherapeutic agents. |
| FILED | Tuesday, April 09, 2019 |
| APPL NO | 17/045802 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) Original (OR) Class A61K 39/4637 (20230501) A61K 45/06 (20130101) A61K 2239/54 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/18 (20180101) A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 9/1205 (20130101) Enzymes C12Y 207/01137 (20130101) C12Y 207/11001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270857 | Park et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeong A. Park (New York, New York); Nai-Kong V. Cheung (New York, New York); Brian Santich (New York, New York) |
| ABSTRACT | The present disclosure provides ex vivo armed T cell (EAT) compositions that comprise multi-specific (e.g., bispecific) antibodies that bind to CDS and at least one additional target antigen (e.g., antigen that is expressed by tumor cells and/or a DOTA label). The EAT compositions of the present technology are useful for adoptive immunotherapy in a subject in need thereof. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 18/007292 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 39/4611 (20230501) Original (OR) Class A61K 39/4633 (20230501) A61K 39/464406 (20230501) A61K 39/464471 (20230501) A61K 51/1093 (20130101) A61K 2239/29 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2809 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) C12N 5/0636 (20130101) C12N 2502/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270861 | WEICHSELBAUM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ralph WEICHSELBAUM (Chicago, Illinois); Hua Laura LIANG (Chicago, Illinois); Yuzhu HOU (Chicago, Illinois) |
| ABSTRACT | This disclosure relates to compositions and methods for treating cancer by modulating the artemin pathway. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 18/006482 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4995 (20130101) A61K 41/0038 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271181 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Michael D. Geuy (State College, Pennsylvania); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A fluidic device includes a fluidic chip having a fluidic network comprising a plurality of fluidic channels in fluidic communication with a plurality of input ports, at least one output port, and at least one sensing port; and an actuator configured to engage with the fluidic network to control each fluidic channel to switch between an open state in which fluidic flow through said fluidic channel is permitted and a closed state in which no fluidic flow through said fluidic channel is permitted, so as to selectively collect fluid from multiple inputs via the plurality of input ports, and direct either all of the multiple inputs to the at least one output port, or all but a single selected input to the at least one output port and the single selected input to the at least one sensing port to which an analytical instrument is operably connected. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 18/015749 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271923 | Nimmagadda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sridhar Nimmagadda (Baltimore, Maryland); Dhiraj Kumar (Baltimore, Maryland); Martin Gilbert Pomper (Baltimore, Maryland) |
| ABSTRACT | The presently disclosed subject matter provides compositions, kits, and methods comprising imaging agents that can detect Programmed Cell Death Ligand 1 (PD-L1). The presently disclosed imaging agents can be used to detect diseases and disorders, such as cancer, infection, and inflammation, in a subject. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 18/040858 |
| CURRENT CPC | Heterocyclic Compounds C07D 209/04 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/534 (20130101) G01N 33/54326 (20130101) G01N 33/54346 (20130101) G01N 33/56911 (20130101) G01N 2800/7095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271994 | CAIANIELLO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David CAIANIELLO (New Haven, Connecticut); Edward DERAMON (New Haven, Connecticut); David SPIEGEL (New Haven, Connecticut) |
| ABSTRACT | The disclosure describes compounds of Formula Ia, which in non-limiting aspects contain an asialoglycoprotein receptor (ASGPR) binding moiety and an anti-β1AR binding moiety. Compounds of Formula Ia are useful in preventing, treating, and/or ameliorating heart failure in a subject when administered in therapeutically effective amounts. |
| FILED | Wednesday, March 08, 2023 |
| APPL NO | 18/180634 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Heterocyclic Compounds C07D 225/08 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230271998 — SOLID SUPPORT FOR SYNTHESIZING NUCLEIC ACID SEQUENCES AND METHODS FOR MAKING AND USING
| US 20230271998 | Beaucage et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Serge L. Beaucage (Silver Spring, Maryland); Andrzej M. Grajkowski (Kensington, Maryland) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland) |
| INVENTOR(S) | Serge L. Beaucage (Silver Spring, Maryland); Andrzej M. Grajkowski (Kensington, Maryland) |
| ABSTRACT | Disclosed herein are embodiments of a solid support suitable for synthesizing nucleic acid sequences. The solid support may have a structure according to Formula I, where CPG is controlled pore glass, and m, n, x, y, R1 and R2 are as defined herein. Also disclosed are methods for making and using the solid support, kits including solid support, and a universal linker phosphoramidite suitable for use in the solid support. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 18/003404 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 50/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272010 | Brady et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean Brady (New York, New York); John Chu (New York, New York) |
| ABSTRACT | The present invention relates to novel compounds and compositions thereof that are useful as antimicrobial agents. The present invention also relates to methods of generating said antimicrobial compounds and compositions thereof as well as methods for treating or preventing a bacterial infection using said compounds or compositions thereof. The present invention further discloses methods for preventing or reducing the growth or proliferation of microorganisms. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/008006 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 7/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272032 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James M. Wilson (Philadelphia, Pennsylvania); Daniel J. Rader (Philadelphia, Pennsylvania); Suryanrayan Somanathan (Boston, Massachusetts) |
| ABSTRACT | A recombinant vector having an expression cassette comprising a modified human low density lipoprotein receptor (hLDLR) gene is provided, wherein said hLDLR gene encodes a modified hLDLR comprising (a) one or more of the following amino acid substitutions: L318H, N295D, H306D, V307D, N309A, D310N, L318H, and/or L318D; or (b) an amino acid substitution of any of (a) in combination with one or more of the following amino acid substitutions: K796, K809R and/or C818A. Also provided are pharmaceutical compositions containing this vector and uses therefor in lowering cholesterol and/or treating familial hypercholesterolemia. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 18/055928 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) A61K 48/005 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272033 | Debinski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Waldemar Debinski (Winston-Salem, North Carolina); Carla Lema Tome (Winston-Salem, North Carolina); Sara Ferluga (Trieste, Italy); Poonam S. Sonawane (Winston-Salem, North Carolina) |
| ABSTRACT | Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some embodiments, the at least one effector molecule comprises a therapeutic agent, a nanoparticle, a detectable group, a lipid, or a liposome. In some embodiments, the construct is a fusion protein and/or a covalent conjugate. Further provided is a construct comprising, in combination: a ligand that binds to EphA2, EphA3 and/or EphB2; a ligand that binds to IL-13Rα2; and at least one effector molecule. Also provided are methods of use thereof for treating cancer. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/316672 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/52 (20130101) C07K 14/705 (20130101) Original (OR) Class C07K 14/5437 (20130101) C07K 2319/01 (20130101) C07K 2319/33 (20130101) C07K 2319/55 (20130101) C07K 2319/74 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272036 | FRUEH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Klaus FRUEH (Portland, Oregon); Louis PICKER (Portland, Oregon); Jonah SACHA (Portland, Oregon); Scott HANSEN (Portland, Oregon); Benjamin BIMBER (Portland, Oregon); Shaheed ABDULHAQQ (Portland, Oregon) |
| ABSTRACT | The present invention provides CD8+ T cells comprising multi-specific T cell receptors and methods for making the same. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 17/786186 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 14/70539 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272038 | Levin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Noam Levin (Rockville, Maryland); Rami Yoseph (Gaithersburg, Maryland); Gal Cafri (Kibbutz Nir David, Israel); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glycine at position 12 with aspartic acid. The TCRs may recognize G12D RAS presented by an HLA-DR heterodimer. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 18/015776 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) A61K 39/4632 (20230501) A61K 39/464464 (20230501) Peptides C07K 14/7051 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5748 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272047 | Sahtoe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danny Sahtoe (Seattle, Washington); Lauren MILLER (Seattle, Washington); Lance Joseph STEWART (Seattle, Washington); David BAKER (Seattle, Washington) |
| ABSTRACT | The present disclosure provides transferring receptor binding polypeptides of the general formula H1-H2-E1-H3-E2-E3-H-4, herein H1, H2, H3, and H4 each independently comprise an alpha, helical domain of between 11-20 amino acids in length; E1, E2, and E3 each independently comprise a beta sheet of 5 amino acids in length; and optional amino acid linkers between domains. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 18/006936 |
| CURRENT CPC | Peptides C07K 14/79 (20130101) Original (OR) Class C07K 2319/75 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272054 | Goodman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven D. Goodman (Columbus, Ohio); Lauren O. Bakaletz (Columbus, Ohio) |
| ABSTRACT | Provided herein are compositions and combinations for the therapeutic and diagnostic use in treating and preventing biofilms and associated disorders using a high mobility group box protein (HMGB) polypeptide, mutant and/or fragment thereof and an anti-DNABII antibody, fragment or variant thereof. The polypeptide and antibody can be administered in the same or separate compositions. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 18/014980 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/40 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/12 (20130101) Original (OR) Class C07K 16/24 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272115 | QUIJANO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Elias QUIJANO (Durham, Connecticut); Audrey TURCHICK (Chelmsford, Massachusetts); Peter GLAZER (Guilford, Connecticut) |
| ABSTRACT | Compositions for enhanced gene editing and methods of use thereof are. The composition contains a cell-penetrating antibody and a donor oligonucleotide containing a sequence that can correct a mutation in a cell's genome. Preferably, the composition does not contain a nuclease, PNA, or nanoparticle. The compositions are used to modify the genome of a cell by contacting the cell with an effective amount of the composition. Genomic modification occurs at a higher frequency both ex vivo and in vivo, when cells are contacted with the cell-penetrating antibody and donor oligonucleotide as compared to the absence of the cell-penetrating antibody. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 18/054080 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 35/14 (20130101) A61K 47/6937 (20170801) A61K 48/0008 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Peptides C07K 16/44 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272120 | He |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mei He (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides immunomagnetic compositions and their methods of use, in particular magnetic particles conjugated to peptides that bind and capture extracellular vesicles. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/998177 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 35/28 (20130101) Peptides C07K 17/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272348 | Lian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaojun Lian (State College, Pennsylvania); Lauren Nicole Randolph (State College, Pennsylvania); Yuqian Jiang (State College, Pennsylvania) |
| ABSTRACT | The present invention relates to a method of producing an enriched preparation of hemogenic endothelial progenitor cells. This method involves providing a population of pluripotent stem cells and inducing expression of a SOXF transcription factor in the pluripotent stem cells of the population. The method further involves culturing the population of pluripotent stem cells expressing the SOXF transcription factor, whereby the enriched preparation of hemogenic endothelial progenitor cells is produced as a result of said culturing. The present invention also relates to a method of producing an enriched preparation of hematopoietic progenitor cells and methods of treating a subject having a condition mediated by a loss or dysfunction of hematopoietic stem cells or by a loss of immune cells. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/012024 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0692 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2501/165 (20130101) C12N 2501/727 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272378 | Lueck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | John D. Lueck (Rochester, New York); Joseph J. Porter (Rochester, New York); Charles A. Thornton (Rochester, New York); Wooree Ko (Rochester, New York) |
| ABSTRACT | This invention relates to compositions and methods for treating a disease or disorder associated with premature termination codon. Certain aspects of the invention relate to polynucleotides, vectors, and host cells, and uses thereof. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 18/000706 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 2310/532 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272380 | Kalhor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reza Kalhor (East Boston, Massachusetts); Prashant G. Mali (La Jolla, California); George M. Church (Brookline, Massachusetts) |
| ABSTRACT | A functional engineered guide RNA sequence is provided including a spacer sequence and a scaffold sequence, wherein the scaffold sequence includes a primer binding site for reverse transcription. |
| FILED | Monday, May 08, 2023 |
| APPL NO | 18/313482 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/10 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 15/1096 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272390 | Blobel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerd Blobel (Bala Cynwyd, Pennsylvania); Xianjiang Lan (Aldan, Pennsylvania); Junwei Shi (Philadelphia, Pennsylvania) |
| ABSTRACT | Methods and compositions for producing fetal hemoglobin and treating a hemoglobinopathy or thalassemia are disclosed. Specifically, the disclosure provides methods of increasing the level of human fetal hemoglobin and/or gamma-globin in a cell or subject, the method comprising administering at least one zinc finger protein 410 (ZNF410) inhibitor to the cell or subject, wherein the subject has a beta-chain hemoglobinopathy, thalassemia, and/or sickle cell disease. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 18/015800 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/16 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272405 | Verardi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paulo Henrique Verardi (Farmington, Connecticut); Brittany Jasperse (Farmington, Connecticut); Caitlin M. O’Connell (Farmington, Connecticut); Yuxiang Wang (Farmington, Connecticut) |
| ABSTRACT | Disclosed herein are flavivirus signal peptide mutants useful for enhancing the production and secretion of flavivirus envelope (E) viral proteins or virus-like proteins. Also disclosed herein are methods of vaccinating subjects (e.g., human subjects) against a flavivirus comprising administering an expression vector, wherein the expression vector comprises a polynucleotide, and a fusion polypeptide comprising an engineered signal peptide and a flavivirus envelope (E) protein |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/012143 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/625 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272424 | Vandenberghe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luk Vandenberghe (Weston, Massachusetts); Guangping Gao (Westborough, Massachusetts); James M. Wilson (Philadelphia, Pennsylvania) |
| ABSTRACT | A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/165138 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0091 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) C12N 2750/14143 (20130101) C12N 2750/14152 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272434 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Abudayyeh (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Lukas Villiger (Cambridge, Massachusetts); Justin Lim (Boston, Massachusetts) |
| ABSTRACT | Genome editing tools for use in systems designed to deliver large genetic elements are disclosed herein. A genome editing system is described, which includes i) an R2 element enzyme or other non-LTR site specific retrotransposon element and ii) a payload RNA, wherein the payload RNA comprises an insertion region and optionally one or more of a 5′ homology region, a 3′ homology region, and a protein binding element, wherein the insertion region comprises a template for a small or large nucleic acid insertion into the genome, and wherein the R2 element enzyme or other non-LTR site specific retrotransposon element comprises a targeting domain, a reverse transcriptase domain, and a nickase domain. Also disclosed are cells edited using such a genome editing system, methods for editing a genome, and compositions comprising cells edited with this genomic editing system. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 18/047685 |
| CURRENT CPC | Peptides C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272435 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Abudayyeh (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Lukas Villiger (Cambridge, Massachusetts); Justin Lim (Boston, Massachusetts) |
| ABSTRACT | This disclosure provides novel integrases for site-specific genetic engineering. Also provided are systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE) with the novel integrases. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 18/048238 |
| CURRENT CPC | Peptides C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/111 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272449 | Milbrandt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey D. Milbrandt (St. Louis, Missouri); Aaron DiAntonio (St. Louis, Missouri); Kow Essuman (St. Louis, Missouri); Xianrong Mao (St. Louis, Missouri); Yo Sasaki (St. Louis, Missouri); Dan Summers (St. Louis, Missouri) |
| ABSTRACT | The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/059838 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/473 (20130101) A61K 31/4425 (20130101) A61K 31/4706 (20130101) A61K 31/4965 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/924 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272452 | Shema-Yaacoby et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); SEQLL INC. (Billerica, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Efrat Shema-Yaacoby (Brookline, Massachusetts); Bradley Bernstein (Cambridge, Massachusetts); Daniel Jones (Boston, Massachusetts) |
| ABSTRACT | The present invention provides for single-molecule profiling of combinatorial protein modifications and single-molecule profiling of combinatorial protein modifications combined with single-molecule sequencing of protein/nucleic acids complexes. High-throughput single-molecule imaging was applied to decode combinatorial modifications on millions of individual nucleosomes from pluripotent stem cells and lineage-committed cells. Applicants identified bivalent nucleosomes with concomitant repressive and activating marks, as well as other combinatorial modification states whose prevalence varies with developmental potency. Applying genetic and chemical perturbations of chromatin enzymes show a preferential affect on nucleosomes harboring specific modification states. The present invention also combines this proteomic platform with single-molecule DNA sequencing technology to simultaneously determine the modification states and genomic positions of individual nucleosomes. This novel single-molecule technology can be used to address fundamental questions in chromatin biology and epigenetic regulation leading to novel therapeutics and diagnostics. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 17/989296 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6806 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272462 | Kline et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Enos Kline (Seattle, Washington); Michael Roller (Seattle, Washington); Robert G. Atkinson (Seattle, Washington); Nuttada Panpradist (Seattle, Washington); Daniel Leon (Seattle, Washington); Ian Hull (Seattle, Washington); Qin Wang (Seattle, Washington); Barry R. Lutz (Seattle, Washington) |
| ABSTRACT | Kits, methods, polypeptides, systems, and non-transitory, machine-readable storage media for detecting a nucleic acid in a sample are described. In an embodiment, the kit comprises a loop primer nucleic acid molecule configured for loop-mediated isothermal amplification (LAMP), the loop primer nucleic acid molecule comprising: a targeting sequence complementary to a target portion of a target nucleic acid sequence; and an adapter sequence; a displacement nucleic acid probe comprising: a fluorophore adapter sequence; and the adapter sequence; and a fluorophore adapter complement nucleic acid molecule complementary to the fluorophore adapter sequence, wherein the fluorophore adapter sequence or the fluorophore adapter complement nucleic acid molecule is coupled to a fluorophore. In an embodiment, the system comprises a thermal subsystem for heating a sample disposed therein, and an optical subsystem for optically excited the sample and detecting light emitted from the sample. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 18/004489 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 7/52 (20130101) B01L 2300/1822 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 2310/122 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) Original (OR) Class C12Q 1/6883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272465 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Eesha Sharma (Stanford, California); Ivan Zheludev (Stanford, California) |
| ABSTRACT | Turning now to the drawings, systems and methods to enhance RNA transcription in a cost-effective manner and uses thereof are provided. One of the most common enzymes for RNA transcription is T7 RNA polymerase. Many embodiments increase RNA yield in transcription reactions by adding ribonucleoside vanadyl complex (VRC) to the transcription reaction. Various embodiments use VRC at low concentrations in an RNA transcription reaction. Reactions in accordance with many embodiments are capable of increasing RNA yield by approximately 2-fold or more. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 18/005515 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1247 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6851 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272466 | ISMAGILOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. ISMAGILOV (Altadena, California); Jacob T. BARLOW (Pasadena, California); Said R. BOGATYREV (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems for absolute quantification of a target 16S rRNA and/or of a target prokaryotic taxon, based on amplifying and sequencing a same 16S rRNA recognition segment in which target 16S rRNA conserved regions flank 16S rRNA variable regions, conserved and variable among a plurality of sample 16S rRNAs and/or of a sample prokaryotic taxon of higher taxonomic rank with respect to the target taxon. In the methods and systems, absolute abundance of the a plurality of sample 16S rRNAs and/or of the sample prokaryotic taxon detected by the amplifying, is multiplied by the relative abundance of the target 16S rRNA and/or of a target prokaryotic taxon detected by the sequencing to provide the absolute quantification in accordance with method and systems of the disclosure. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863183 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272471 | DENG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Mario DENG (VENICE, California); Galyna BONDAR (LOS ANGELES, California) |
| ABSTRACT | Gene expression is measured in a sample of peripheral blood mononuclear cells (PBMCs) obtained from a subject and used to predict organ function recovery. A Function Recovery Potential (FRP) score is assigned to a sample that reflects the measured expression level of the genes identified herein in a direction associated with recovery from organ failure. Treatment of the subject with optimal medical management (OMM) and/or palliative care (PC) is advised when the FRP score is lower than the reference value, and referring the subject for treatment with therapies including—but not limited to—mechanical circulatory support (MCS) surgery, heart transplant (HTx) surgery, or other intervention for advanced heart failure is advised when the FRP score is greater than the reference value. A method for developing an FRP scoring algorithm that predicts a subject's ability to recover from medical intervention for organ failure is also described. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/049257 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Original (OR) Class C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272474 | DORSEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathleen C. DORSEY (Pittsboro, North Carolina); Nancy E. THOMAS (Durham, North Carolina); Sharon N. EDMISTON (Chapel Hill, North Carolina); Pamela A. GROBEN (Mebane, North Carolina); Joel S. PARKER (Apex, North Carolina) |
| ABSTRACT | This disclosure is directed to a method for detecting melanoma in a tissue sample by measuring a level of methylation of one or more regulatory elements differentially methylated in melanoma and benign nevi. The invention provides methods for detecting melanoma, related kits, and methods of screening for compounds to prevent or treat melanoma. |
| FILED | Friday, January 18, 2019 |
| APPL NO | 16/963063 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272479 | Winter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob M. Winter (Salt Lake City, Utah); Jared Rutter (Salt Lake City, Utah) |
| ABSTRACT | Disclosed are any of the methods or compositions herein. Disclosed are methods of treating a subject having cancer comprising administering a proteasome inhibitor to the subject having cancer, wherein the subject having cancer has a non-functional ATAD1 gene. Disclosed are methods of diagnosing and treating cancer, the method comprising: diagnosing a subject as being susceptible to treatment by a proteasome inhibitor; and administering a proteasome inhibitor to the subject. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 18/010580 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 38/07 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272493 | Guerrero-Preston |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rafael Guerrero-Preston (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafael Guerrero-Preston (Baltimore, Maryland) |
| ABSTRACT | Methods of detecting, including early detection, of cancer mediated by SARS-CoV-2 and HPV, may include detection of such viral infections alone or together with one or more biomarkers selected from gene specific DNA methylation levels, whole genome DNA methylation levels, host RNA expression levels, T-Cell receptor amount or clonality, B-Cell receptor amount or clonality, microbiome. One method includes analysis of SARS-CoV-2 nucleic acid and the one or more biomarkers from samples of the same tissue, biofluid, or both. These methods are useful for, among other things, assessing the effectiveness of treatment, monitoring relapse, and clinical staging of cancer. These methods are also useful for among other things to monitor the effectiveness of strategies and therapies used to modify lifestyle and contextual effects to prevent disease, foster wellness and enable health promotion. |
| FILED | Monday, April 17, 2023 |
| APPL NO | 18/135484 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/708 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6886 (20130101) C12Q 2600/154 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273210 | Fine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Barry Fine (Mamaroneck, New York); Nicholas Tatonetti (New York, New York); Nicholas Giangreco (Buffalo, New York) |
| ABSTRACT | Described here are techniques for identifying risk of primary graft dysfunction (PGD) of a subject. The disclosed method can include collecting serum of the subject, measuring a level of a PGD marker from the serum, wherein the PGD marker comprises plasma kallikrein (KLKB1), providing a PGD risk value that is quantified based on the level of the PGD marker using an adaptive Monte Carlo cross-validation (MCCV) model, and identifying the risk of PGD based on the PGD risk value. |
| FILED | Thursday, March 09, 2023 |
| APPL NO | 18/180991 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 7/01 (20230101) G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273223 | CHRISTOFIDOU-SOLOMIDOU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Melpo CHRISTOFIDOU-SOLOMIDOU (Eagleville, Pennsylvania); Shampa Chatterjee (Philadelphia, Pennsylvania); Thais Sielecki-Dzurd (Kennett Square, Pennsylvania); Ralph Pietrofesa (Harrisburg, Pennsylvania) |
| ABSTRACT | The present invention relates to a panel of inflammasone biomarkers for detecting exposure to ionizing radiation and/or for determining absorbed dose of ionizing radiation in a subject exposed thereto. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 18/040641 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/40 (20130101) G01N 2800/7095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273417 | Cui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meng Cui (West Lafayette, Indiana); Hehai Jiang (West Lafayette, Indiana) |
| ABSTRACT | A confocal microscope system includes a light source configured to form a light beam, a scanning unit, and an objective lens. The scanning unit is in the form of a mechanically driven scanning unit with a controllable scanning trajectory, and is configured to direct the light beam through the scanning trajectory. The objective lens defines a pupil plane and a focal plane. The light beam is directed from the scanning unit to the objective lens. The confocal microscope system is configured for multi-color line-scanning confocal microscopy, and implements multi-color fluorescence imaging without laser excitation crosstalk. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/885728 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 13/22 (20130101) G02B 13/0095 (20130101) G02B 21/02 (20130101) G02B 21/008 (20130101) G02B 21/0032 (20130101) Original (OR) Class G02B 21/0036 (20130101) G02B 21/0072 (20130101) G02B 21/0076 (20130101) G02B 27/141 (20130101) G02B 27/1013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230274055 | Horbatiuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | Wayne State University (Detroit, Michigan) |
| INVENTOR(S) | Jeffrey Horbatiuk (Shelby Township, Michigan); Carolyn Harris (Grosspointe Farms, Michigan); Lubna Alazzawi (Deer Point Heights, Michigan); Ahmad Faryami (Farmington Hills, Michigan) |
| ABSTRACT | Described herein are systems and methods for modeling fluid flow. The systems may comprise a plurality of chambers, a plurality of sensors, a pump, a plurality of valves, and a flow limiting operator (FLO). The respective sensor of the plurality of sensors may be configured to sense a respective monitoring parameter associated with the respective chamber. The pump may be configured to move media to or from the respective chamber. The respective valve of the plurality of valves may be configured to control a fluid velocity of the media flowing through the respective chamber. The FLO may be electrically connected to the plurality of sensors, the pump, and the plurality of valves. The FLO may be configured to independently control the respective chamber by manipulating one or more controllable parameters associated with the respective chamber based on the respective monitoring parameter associated with the respective chamber. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 18/005583 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/24 (20130101) Electric Digital Data Processing G06F 30/28 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230274562 | Collazo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Collazo (Tampa, Florida); Lawrence Hall (Tampa, Florida); Dmitry Goldgof (Tampa, Florida); Samuel Wickline (Tampa, Florida); Hua Pan (Tampa, Florida) |
| ABSTRACT | Bootstrapped semantic preprocessing techniques for medical datasets such as whole slide histopathology image datasets can be used to more efficiently and effectively train artificial intelligence used for medical purposes. The bootstrapped semantic preprocessing techniques generally include deriving metrics from image features and adjusting images according to the metrics. This process can be repeated iteratively for unknown and unlabeled data using a bootstrapping technique to normalize unknown samples to the training dataset distribution. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/175305 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/774 (20220101) G06V 10/7788 (20220101) G06V 20/70 (20220101) G06V 20/695 (20220101) Original (OR) Class G06V 20/698 (20220101) G06V 2201/03 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275466 | AHN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Korea Advanced Institute of Science and Technology (Daejeon, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seungyoung AHN (Daejeon, South Korea); Jedok KIM (Daejeon, South Korea); Jangyong AHN (Daejeon, South Korea) |
| ABSTRACT | A wireless power transmission apparatus comprises a feeding coil configured to be wound a plurality of times with respect to a center, generate a time-varying magnetic field according to operating frequency of a supply power, and wirelessly transmit an electrical energy to a collecting coil exposed to the time-varying magnetic field through magnetic inductive coupling; and a feeding auxiliary coil configured to be wound along with the feeding coil a plurality of times with respect to the same center as the feeding coil, generate an auxiliary magnetic field with a phase that affects the feeding coil, and provide additional inductance generated by the auxiliary magnetic field. |
| FILED | Monday, May 08, 2023 |
| APPL NO | 18/313432 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 38/14 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/005 (20200101) H02J 50/12 (20160201) Original (OR) Class H02J 50/402 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275557 | Degertekin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fahrettin Levent Degertekin (Atlanta, Georgia); Sushruta Shashidhara Surappa (Atlanta, Georgia) |
| ABSTRACT | A resonator-based comb generation system configured for stable frequency comb generation in a media environment across a range of media environment densities. A system configured for frequency comb generation in a media environment across a range of media environment densities can include a resonant mechanical assembly and a resonant electrical assembly, wherein the assemblies are non-linearly coupled. A microelectromechanical (MEM) resonator can be parametrically coupled to a resonant electrical circuit to serve as an electromechanical comb generation system. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/309847 |
| CURRENT CPC | Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/02259 (20130101) Original (OR) Class H03H 9/2426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230270067 | Dawe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia); Cold Spring Harbor Laboratory (Cold Spring Harbor, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Kelly Dawe (Athens, Georgia); David Jackson (Brooklyn, New York) |
| ABSTRACT | Monocot plants heterozygous for centromeric histone 3 (CenH3) and optionally expressing gene editing constructs, for use in inducing haploids of a monocot target plant and optionally pass-through gene editing are provided. The monocot haploid inducer plants are typically composed of diploid plant cells having only one allele encoding a functional CENH3 protein. The diploid plant cells can also include, for example, one CenH3 allele encoding non-functional CENH3 protein. In some embodiments, the allele encoding non-functional CENH3 protein is a frameshift mutation, protein null allele, an RNA null allele, or a combination thereof. The monocot haploid inducer plant can also include gene editing machinery, such as a site-directed nuclease and optionally a guide RNA stably expressed by cells of the monocot plant. Methods of inducing formation of a target haploid monocot plant while optionally simultaneously modifying the target monocot plant’s genome are also provided. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 18/001370 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/08 (20130101) Original (OR) Class Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/8213 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6895 (20130101) C12Q 2600/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270104 | Marenda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel R. Marenda (Elkins Park, Pennsylvania); Sean O'Donnell (Swarthmore, Pennsylvania) |
| ABSTRACT | The disclosure provides a human-safe method of killing or controlling insects using a non-toxic composition comprising erythritol ((2R,3S)-butane-1,2,3,4-tetraol). The disclosure also provides non-toxic compositions comprising erythritol suitable for killing insects in residential, commercial, and agricultural locales. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 18/024082 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) A01N 25/006 (20130101) Original (OR) Class A01N 25/30 (20130101) A01N 31/02 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 19/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270372 | Rogers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Rogers (Wilmette, Illinois); Roozbeh Ghaffari (Cambridge, Massachusetts); Kyeongha Kwon (Evanston, Illinois); Jong Uk Kim (Evanston, Illinois) |
| ABSTRACT | This invention discloses a sensor for measuring parameters of sweat from a skin, comprising a flexible structure comprising a fluid passage having inlet and outlet, the flexible structure being detachably attached to the skin and configured such that sweat enters the inlet as the sweat releases from the skin and flows through the fluid passage into the outlet; a thermal actuator disposed on the flexible structure over the fluid passage and configured to operably provide heat to flow of the sweat through the fluid passage; a first thermistor disposed on the flexible structure over the fluid passage between the inlet and the thermal actuator and configured to operably measure a first temperature of the sweat thereon; and a second thermistor disposed on the flexible structure over the fluid passage between the thermal actuator and the outlet and configured to operably measure a second temperature of the sweat thereon. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 18/014362 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/002 (20130101) A61B 5/4266 (20130101) Original (OR) Class A61B 5/6833 (20130101) A61B 5/7225 (20130101) A61B 2562/164 (20130101) A61B 2562/0271 (20130101) Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/63 (20180101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/042 (20130101) G05B 2219/2614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270497 | Zharov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BioVentures, LLC (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Pavlovich Zharov (Little Rock, Arkansas); Ekaterina Galanzha (Little Rock, Arkansas) |
| ABSTRACT | A device and method of using the device to detect the presence and composition of clots and other target objects in a circulatory vessel of a living subject is described. In particular, devices and methods of detecting the presence and composition of clots and other target objects in a circulatory vessel of a living subject using in vivo photoacoustic flow cytometry techniques is described. |
| FILED | Friday, February 03, 2023 |
| APPL NO | 18/105636 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/0095 (20130101) A61B 5/412 (20130101) A61B 5/415 (20130101) A61B 5/416 (20130101) A61B 5/418 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/1495 (20130101) A61B 5/02007 (20130101) A61B 5/4839 (20130101) A61B 5/7282 (20130101) A61B 5/7405 (20130101) A61B 5/7455 (20130101) A61B 5/14535 (20130101) A61B 8/06 (20130101) A61B 8/08 (20130101) A61B 8/481 (20130101) A61B 18/245 (20130101) Original (OR) Class A61B 18/1815 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/22 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/30 (20130101) B03C 1/288 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/1702 (20130101) G01N 29/2418 (20130101) G01N 29/4427 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270571 | Goldfarb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Goldfarb (Nashville, Tennessee); Steven C. Culver (Nashville, Tennessee); Leo G. Vailati (Nashville, Tennessee) |
| ABSTRACT | A knee prosthesis system including a knee prosthesis, an actuator and a controlling unit. The knee prosthesis includes a thigh segment and a shank segment. The actuator rotatably connects the shank segment and the thigh segment. The actuator is configured to controllably assume a powered knee behavior to generate knee motion or a passive knee behavior to resist knee motion. The controlling unit includes a finite-state control structure. The controlling unit electrically communicates with the actuator. The control structure includes at least three passive states and at least one powered state. The passive states include a passive stance-resistance state, a swing-flexion state, and a swing-extension state and the at least one powered state includes at least one of a swing-assistance state, a stance-assistance state, and a powered-swing state. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/173983 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/64 (20130101) Original (OR) Class A61F 2002/607 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270919 | Gerecht et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sharon Gerecht (Severna Park, Maryland); Morgan B. Elliott (Baltimore, Maryland); Hai - Quan Mao (Baltimore, Maryland); Jessica Shen (Baltimore, Maryland) |
| ABSTRACT | Described are methods of making vascular grafts from man-made tubular scaffolds, tubular scaffolds, and methods implanting vascular grafts comprising tubular scaffolds into subjects. The tubular scaffolds of the present invention are made of hydrogel nanofibers that have internally aligned polymer chains and may be cellularized. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/766569 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Original (OR) Class A61L 27/507 (20130101) A61L 27/3808 (20130101) A61L 2400/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271011 | MORTIZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Abed KHORASANI (Seattle, Washington); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | Abed KHORASANI (Seattle, Washington); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Chet T. MORTIZ (Seattle, Washington); Abed KHORASANI (Seattle, Washington); Soshi SAMEJIMA (Seattle, Washington); Nicholas TOLLEY (Seattle, Washington) |
| ABSTRACT | Systems and methods for high frequency epidural stimulation to control sensation are disclosed herein. In one embodiment, a method for restoring physiological function in a subject having a neurological impairment includes generating a stimulation pattern. The stimulation pattern includes pulses at a first frequency, where the pulses of the stimulation pattern are modulated by a modulation pattern at a second frequency. The second frequency is higher than the first frequency. The method also includes stimulating a region of the spinal cord with the stimulation pattern via one or more electrodes. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 18/007948 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36067 (20130101) Original (OR) Class A61N 1/36139 (20130101) A61N 1/36196 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271139 | Floyd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SolMem LLC (Houston, Texas); WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Allen Floyd (Bellaire, Texas); Ibrahim Abdallah (Houston, Texas); Ze He (Houston, Texas); Jinjian Wu (Shanghai, China PRC); Qilin Li, Dr. (Houston, Texas) |
| ABSTRACT | A distillation device and method of manufacturing a distillation device is disclosed. The distillation device includes at least one spiral wound membrane distillation (MD) unit. The spiral wound MD unit includes a perforated center tube concentric to a cylindrical housing and a plurality of effects spirally wound around the center tube. Each of the effects include a vapor permeable membrane, a feed spacer disposed on the vapor permeable membrane, a permeate spacer, and a heat exchange film. The permeate spacer is disposed between the vapor permeable membrane and the heat exchange film. Distillation of a feed fluid by the plurality of effects deposits a condensate fluid into the center tube. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 18/016003 |
| CURRENT CPC | Separation B01D 61/364 (20130101) B01D 61/366 (20130101) B01D 63/12 (20130101) Original (OR) Class B01D 2311/1031 (20220801) B01D 2313/10 (20130101) B01D 2313/221 (20220801) B01D 2313/246 (20130101) B01D 2319/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271181 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Michael D. Geuy (State College, Pennsylvania); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A fluidic device includes a fluidic chip having a fluidic network comprising a plurality of fluidic channels in fluidic communication with a plurality of input ports, at least one output port, and at least one sensing port; and an actuator configured to engage with the fluidic network to control each fluidic channel to switch between an open state in which fluidic flow through said fluidic channel is permitted and a closed state in which no fluidic flow through said fluidic channel is permitted, so as to selectively collect fluid from multiple inputs via the plurality of input ports, and direct either all of the multiple inputs to the at least one output port, or all but a single selected input to the at least one output port and the single selected input to the at least one sensing port to which an analytical instrument is operably connected. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 18/015749 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271234 | Campanella et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| ASSIGNEE(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| INVENTOR(S) | Andrew Campanella (Somerville, Massachusetts); Joseph G. Michels (New York, New York); Peter Quigley (Duxbury, Massachusetts); Ian Martin (Sharon, Massachusetts) |
| ABSTRACT | A control system for controlling extraction of landfill gas, comprising: at least one sensor configured to measure one or more characteristics of landfill gas; at least one flow control mechanism disposed in well piping and configured to control flow of the landfill gas through the well piping; and at least one processor configured to: obtain a measured concentration of a first gas in landfill gas; determine whether the measured concentration of the first gas is either less than a first threshold concentration or greater than a second threshold concentration; when it is determined that the measured concentration is less than the first threshold concentration, control the at least one flow control mechanism to reduce flow rate of landfill gas; and when it is determined that the concentration is greater than the second threshold concentration, control the at least one flow control mechanism to increase the flow rate of landfill gas. |
| FILED | Tuesday, February 14, 2023 |
| APPL NO | 18/168983 |
| CURRENT CPC | Disposal of Solid Waste B09B 1/006 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271377 | CAI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liheng CAI (Charlottesville, Virginia); Jinchang ZHU (Charlottesville, Virginia) |
| ABSTRACT | Systems and methods for 3D bioprinting of hydrogel voxels enable microfluidics-assisted digital assembly of spherical particles (DASP). The systems include a 3D motion system, a microfluidic printhead coupled to the 3D motion system, an extrusion device fluidly coupled to the microfluidic printhead, and a sacrificial support matrix. The sacrificial support matrix is designed to support the hydrogel voxels during printing and cross-link the hydrogel voxels. The system includes bio-inks comprising hydrogel compositions having independently controllable viscoelasticity and mesh size. The bio-inks are extruded by the extrusion device and microfluidic printhead to produce the hydrogel voxels. Exploiting the microfluidic printhead enables printing individual spherical hydrogel voxels with diameters from 150 micrometers (μm) to 1200 μm. Positioning and interconnection of the hydrogel voxels can be precisely controlled. The systems and methods produce free-standing 3D structures and can be used for producing functional tissue mimics. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 18/010993 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/40 (20170801) B29C 64/106 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/227 (20170801) B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271381 | Garrod et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHROMATIC 3D MATERIALS, INC. (Golden Valley, Minnesota) |
| ASSIGNEE(S) | CHROMATIC 3D MATERIALS, INC. (Golden Valley, Minnesota) |
| INVENTOR(S) | Michael Garrod (Minnetrista, Minnesota); Shihchuan Kao (New Brighton, Minnesota); Garth Benson (Burnsville, Minnesota) |
| ABSTRACT | A three-dimensional (3D) object and a 3D object production process comprising: providing a thermoset printing apparatus comprising: a mixing chamber to receive and mix at least a first reactive component and a second reactive component to provide a thermosetting material, an extrusion nozzle to deliver the thermosetting material to form a 3D object, at least one actuator coupled to the extrusion nozzle to move the extrusion nozzle when delivering the thermosetting material to form the 3D object, and a controller comprising one or more processors and coupled to the extruded thermoset printing apparatus, and depositing the thermosetting material to form the 3D object, wherein the depositing comprises depositing a lead-in block layer of thermosetting material, depositing a lead-in bridge layer of thermosetting material, depositing a main part layer of thermosetting material, depositing a lead-out bridge layer, and depositing a lead-out block layer. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 18/040281 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/141 (20170801) Original (OR) Class B29C 64/371 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271822 | de Boer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maarten P. de Boer (Barcelona, Spain); Longchang Ni (Pittsburgh, Pennsylvania); Ryan M. Pocratsky (Pittsburgh, Pennsylvania) |
| ABSTRACT | A micro-electromechanical system (MEMS) device includes a silicon substrate; and a Tantalum (Ta) layer comprising a first portion and a second portion, a first portion being suspended over the silicon substrate and configured to move relative to the silicon substrate, and the second portion of the structure being coupled to the silicon substrate and fixed in place relative to the silicon substrate. MEMS devices including accelerometers, gyroscopes, microphones, etc. can be fabricated in which Ta forms the structure material of the MEMS components on a chip. The Ta and integrated circuit (IC) can be fabricated together in a single package in which the MEMS structure is able to use the full area above the IC in the package. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 18/010011 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0021 (20130101) Original (OR) Class B81B 2201/0235 (20130101) B81B 2203/0118 (20130101) B81B 2203/0307 (20130101) B81B 2207/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271842 | Nair et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sankar Nair (Atlanta, Georgia); Christopher W. Jones (Atlanta, Georgia); Akshay Korde (Atlanta, Georgia); Johannes Leisen (Atlanta, Georgia); Byunghyun Min (Atlanta, Georgia); Ziyuan Wang (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sankar Nair (Atlanta, Georgia); Christopher W. Jones (Atlanta, Georgia); Akshay Korde (Atlanta, Georgia); Johannes Leisen (Atlanta, Georgia); Byunghyun Min (Atlanta, Georgia); Ziyuan Wang (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein are nanostructured hierarchical zeolitic materials comprising: a plurality of zeolite nanotubes, each zeolite nanotube comprising a zeolitic wall perforated by a plurality of pores, the zeolitic wall defining a single longitudinal lumen. Also disclosed herein are bolaform structure directing agents comprising: a first hydrophilic end and a second hydrophilic end with a hydrophobic core therebetween; the hydrophobic core comprising one or more aromatic rings and one or more hydrophobic alkyl groups; the one or more aromatic rings comprising a biphenyl group; the one or more hydrophobic alkyl groups each independently comprising a C10 alkyl group; and the first hydrophilic end and the second hydrophilic end each independently comprising a quinuclidinium group. Also disclosed herein are methods of making and use of the plurality of zeolite nanotubes and the bolaform structure directing agents. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 18/019315 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/18 (20130101) B01J 20/2808 (20130101) B01J 20/3057 (20130101) B01J 20/28007 (20130101) B01J 20/28023 (20130101) B01J 20/28061 (20130101) B01J 20/28064 (20130101) B01J 20/28066 (20130101) B01J 20/28083 (20130101) B01J 29/7007 (20130101) B01J 35/006 (20130101) B01J 35/0013 (20130101) B01J 35/023 (20130101) B01J 35/1019 (20130101) B01J 35/1023 (20130101) B01J 35/1028 (20130101) B01J 35/1057 (20130101) B01J 35/1061 (20130101) B01J 37/0018 (20130101) Non-metallic Elements; Compounds Thereof; C01B 39/48 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2002/84 (20130101) C01P 2002/86 (20130101) C01P 2002/88 (20130101) C01P 2004/04 (20130101) C01P 2004/13 (20130101) C01P 2004/54 (20130101) C01P 2004/64 (20130101) C01P 2006/12 (20130101) C01P 2006/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271865 | YEH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (TAMPA, Florida); UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel H. YEH (Tampa, Florida); Melanie T. PICKETT (Tampa, Florida); Luke ROBERSON (Orlando, Florida); Jorge L. CALABRIA (Tampa, Florida); Talon BULLARD (Tampa, Florida) |
| ABSTRACT | A closed-loop, bioregenerative water purification system including a gravity-independent anaerobic membrane bioreactor capable of operating in the presence and absence of gravity, the bioreactor including an anaerobic bioreactor, a first membrane filtration unit, and a second membrane filtration unit, wherein the anaerobic bioreactor is configured to receive organic waste and hygiene water as inputs and break them down into constituent components using anaerobic microbes, wherein the first membrane filtration unit is configured to receive effluent output from the anaerobic bioreactor, return concentrate to the anaerobic bioreactor, and output permeate to the second membrane filtration unit, and wherein the second membrane filtration unit is configured to receive the permeate output from the first membrane filtration unit, separate biogas from the permeate, and output nutrient-rich water. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 18/011031 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 31/00 (20130101) Separation B01D 19/0031 (20130101) B01D 53/229 (20130101) B01D 61/145 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/2853 (20130101) C02F 9/00 (20130101) Original (OR) Class Organic Fertilisers Not Covered by Subclasses C05B, C05C, e.g Fertilisers From Waste or Refuse C05F 3/04 (20130101) C05F 7/00 (20130101) C05F 17/40 (20200101) C05F 17/80 (20200101) C05F 17/971 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272130 | Pyun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong-Chul Pyun (Tucson, Arizona); Robert A. Norwood (Tucson, Arizona); Roland Himmelhuber (Tucson, Arizona); Tristan Stephen Kleine (Tucson, Arizona); Liliana Ruiz Diaz (Tucson, Arizona); Laura E. Anderson (Tucson, Arizona) |
| ABSTRACT | The present invention provides certain polymeric materials, precursors thereof as well as the preparation and uses thereof. |
| FILED | Thursday, May 04, 2023 |
| APPL NO | 18/143562 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 329/10 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 112/30 (20200201) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272159 | Becker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Matthew Becker (Chapel Hill, North Carolina); Garrett Fredric Bass (Durham, North Carolina) |
| ASSIGNEE(S) | THE UNIVERSITY OF AKRON (AKRON, Ohio) |
| INVENTOR(S) | Matthew Becker (Chapel Hill, North Carolina); Garrett Fredric Bass (Durham, North Carolina) |
| ABSTRACT | In one or more embodiments, the present invention provides am method of making a poly(propylene fumarate-co-succinate) (PPFS) copolymer containing a random incorporation of succinate groups and targetable reduction profiles without the need for three or more monomer units. To achieve this, a time-dependent sonication-promoted zinc/acetic acid reduction of the PPM unsaturated double bonds has been used to create a random PPMS copolymer which may be isomerized into the PPFS equivalent. By changing the sonication time as well as the ratios of acetic acid, zinc, and PPM unsaturated alkenes, partial reduction of the PPM alkenes has been shown to give PPMS products containing varying compositions of succinic and maleate units, which may then be isomerized to the PPFS product. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 18/005643 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/83 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272348 | Lian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaojun Lian (State College, Pennsylvania); Lauren Nicole Randolph (State College, Pennsylvania); Yuqian Jiang (State College, Pennsylvania) |
| ABSTRACT | The present invention relates to a method of producing an enriched preparation of hemogenic endothelial progenitor cells. This method involves providing a population of pluripotent stem cells and inducing expression of a SOXF transcription factor in the pluripotent stem cells of the population. The method further involves culturing the population of pluripotent stem cells expressing the SOXF transcription factor, whereby the enriched preparation of hemogenic endothelial progenitor cells is produced as a result of said culturing. The present invention also relates to a method of producing an enriched preparation of hematopoietic progenitor cells and methods of treating a subject having a condition mediated by a loss or dysfunction of hematopoietic stem cells or by a loss of immune cells. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/012024 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0692 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2501/165 (20130101) C12N 2501/727 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272446 | PARMEGGIANI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fabio PARMEGGIANI (Seattle, Washington); TJ BRUNETTE (Seattle, Washington); Po-Ssu HUANG (Seattle, Washington); David BAKER (Seattle, Washington) |
| ABSTRACT | Methods and systems for designing proteins are disclosed, as well as proteins and protein assemblies designed. A computing device can determine a protein repeating unit that includes one or more protein helices and one or more protein loops. The computing device can generate a protein backbone structure with a copy of the protein repeating unit. The computing device can determine whether a distance between a pair of helices of the protein backbone structure is between lower and upper distance thresholds. After determining that the distance between the pair of helices is between the lower and upper distance thresholds, the computing device can: generate a plurality of protein sequences based on the protein backbone structure, select a particular protein sequence of the plurality of protein sequences based on an energy landscape that has information about energy and distance from a target fold of the particular protein sequence, and generate an output based on the particular protein sequence. |
| FILED | Friday, May 05, 2023 |
| APPL NO | 18/312788 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 2800/101 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272466 | ISMAGILOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. ISMAGILOV (Altadena, California); Jacob T. BARLOW (Pasadena, California); Said R. BOGATYREV (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems for absolute quantification of a target 16S rRNA and/or of a target prokaryotic taxon, based on amplifying and sequencing a same 16S rRNA recognition segment in which target 16S rRNA conserved regions flank 16S rRNA variable regions, conserved and variable among a plurality of sample 16S rRNAs and/or of a sample prokaryotic taxon of higher taxonomic rank with respect to the target taxon. In the methods and systems, absolute abundance of the a plurality of sample 16S rRNAs and/or of the sample prokaryotic taxon detected by the amplifying, is multiplied by the relative abundance of the target 16S rRNA and/or of a target prokaryotic taxon detected by the sequencing to provide the absolute quantification in accordance with method and systems of the disclosure. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863183 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273077 | Thevamaran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); Wesleyan University (Middletown, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramathasan Thevamaran (Madison, Wisconsin); Jizhe Cai (Madison, Wisconsin); Tsampikos Kottos (Farmington, Connecticut); Fred Ellis (Middletown, Connecticut); Rodion Kononchuk (Meriden, Connecticut) |
| ABSTRACT | One or more computing devices, systems, and/or methods are provided. In an example, a method includes tuning a sensor comprising a first resonator having an effective gain, a second resonator having an effective loss, and a coupling circuit connected between the first resonator and the second resonator at an extrema degeneracy point with a nonlinear response to a force applied to the sensor. At least one of the first resonator, the second resonator, or the coupling circuit comprises a variable capacitor having a capacitance that varies as a function of the force. The method comprises injecting an input signal into one of the first resonator or the second resonator, receiving an output signal from one of the first resonator or the second resonator, and determining a magnitude of a force based on a difference between a first frequency extrema point and a second frequency extrema point in the output signal. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/681320 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/142 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273571 | DeLacy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ballydel Technologies, Inc. (Wilmington, Delaware) |
| ASSIGNEE(S) | Ballydel Technologies, Inc. (Wilmington, Delaware) |
| INVENTOR(S) | Brendan G. DeLacy (Wilmington, Delaware); Mark S. Mirotznik (Wilmington, Delaware); Benjamin S. Garrett (Wilmington, Delaware) |
| ABSTRACT | A computerized system for uniquely tagging and verifying authenticity of an article comprising: an object having a curvature; a computer system adapted to: receive a three-dimensional predetermined image, create a holographic interference pattern created according to the three-dimensional predetermined image and the curvature wherein the holographic interference pattern is applied to the object, project a three-dimensional resulting image projected on a planar surface in response to the holographic interference pattern being illuminated wherein the computer system receives the three-dimensional resulting image, create validation information according to a comparison of the three-dimensional predetermined image and the three-dimensional resulting image |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/176269 |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/0011 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/88 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230274156 | HAMERLY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ryan HAMERLY (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); NTT Research, Incorporated (Sunnyvale, California) |
| INVENTOR(S) | Ryan HAMERLY (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | NetCast is an optical neural network architecture that circumvents constraints on deep neural network (DNN) inference at the edge. Many DNNs have weight matrices that are too large to run on edge processors, leading to limitations on DNN inference at the edge or bandwidth bottlenecks between the edge and server that hosts the DNN. With NetCast, a weight server stores the DNN weight matrix in local memory, modulates the weights onto different spectral channels of an optical carrier, and distributes the weights to one or more clients via optical links. Each client stores the activations, or layer inputs, for the DNN and computes the matrix-vector product of those activations with the weights from the weight server in the optical domain. This multiplication can be performed coherently by interfering the spectrally multiplexed weights with spectrally multiplexed activations or incoherently by modulating the weight signal from the weight server with the activations. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 18/247129 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/098 (20230101) Original (OR) Class G06N 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275417 | Mehraeen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shahab Mehraeen (Baton Rouge, Louisiana); Sudipta Sen (Baton Rouge, Louisiana) |
| ABSTRACT | The present disclosure provides a DC mechanical circuit breaker that can utilize two switches, one of which can generate zero-crossing with an alternate oscillatory circuit for the other one, which can be a conventional zero-crossing-based AC breaker and can be used in the main circuit. This is different from the conventional single-switch commute-and-absorb method currently used. The present disclosure shows that disclosed circuit breaker improves the fault current extinction and significantly reduces the voltage rate-of-change while creating the current zero-crossing faster compared to the available technology. Thus, disclosed circuit breaker is capable of interrupting high DC currents with minimal arc through a less expensive AC circuit breaker. Simulation and hardware results are provided to show the efficiency of the disclosed circuit breaker. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/110509 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/3272 (20130101) Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 9/54 (20130101) H01H 33/596 (20130101) Emergency Protective Circuit Arrangements H02H 1/063 (20130101) H02H 3/021 (20130101) H02H 3/087 (20130101) Original (OR) Class H02H 9/02 (20130101) Pulse Technique H03K 17/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275557 | Degertekin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fahrettin Levent Degertekin (Atlanta, Georgia); Sushruta Shashidhara Surappa (Atlanta, Georgia) |
| ABSTRACT | A resonator-based comb generation system configured for stable frequency comb generation in a media environment across a range of media environment densities. A system configured for frequency comb generation in a media environment across a range of media environment densities can include a resonant mechanical assembly and a resonant electrical assembly, wherein the assemblies are non-linearly coupled. A microelectromechanical (MEM) resonator can be parametrically coupled to a resonant electrical circuit to serve as an electromechanical comb generation system. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/309847 |
| CURRENT CPC | Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/02259 (20130101) Original (OR) Class H03H 9/2426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275741 | DACHMAN-SOLED et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NTT RESEARCH INC. (Sunnyvale, California) |
| ASSIGNEE(S) | NTT RESEARCH INC. (Sunnyvale, California) |
| INVENTOR(S) | DANA DACHMAN-SOLED (COLLEGE PARK, Maryland); ILAN KOMARGODSKI (Tel Aviv, Israel); RAFAEL N PASS (New York, New York) |
| ABSTRACT | Systems, methods, network devices, and machine-readable media disclosed herein include encoding data for storage or transmission by encoding the data according to a tamper-resistant data encoding scheme that renders the data secure against unbounded polynomial size attacks. The present disclosure further includes subsequently determining whether the data has been tampered with, and notifying a processor when the data has been modified or compromised. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/012226 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/005 (20130101) Original (OR) Class H04L 9/3218 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275785 | Nguyen |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | San Diego State University Research Foundation (San Diego, California) |
| ASSIGNEE(S) | San Diego State University Research Foundation (San Diego, California) |
| INVENTOR(S) | Huu Ngoc Duy Nguyen (San Diego, California) |
| ABSTRACT | Systems, apparatus, and methods for channel estimation and data detection. In one exemplary embodiment, the data is obtained in a two-phase transmission structure that alternates known data with unknown data according to a regular or otherwise pre-determined time interval. Then, the receiver iteratively updates a postulated channel, and provides a predicted channel to the next time slot. Conceptually, the exemplary techniques iteratively improve its postulates for channel condition and data over multiple time slots. More directly, instead of linear detection and decoding of a pilot for channel estimation in each time slot, the exemplary techniques described herein use postulated channel conditions to attempt data detection and use the recovered data from data detection (unknown data) to re-postulate the channel conditions, etc. until channel conditions are stable and/or the next time slot is ready for processing. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/174555 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 25/021 (20130101) H04L 25/024 (20130101) H04L 25/0204 (20130101) Original (OR) Class H04L 25/0224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230270903 | Bohnert et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George William Bohnert (Kansas City, Missouri); Darren Radke (Kansas City, Missouri); Domenick Leto (Kansas City, Missouri) |
| ABSTRACT | A hydrogen peroxide sterilization device for sterilizing a medical device, the hydrogen peroxide sterilization device including a hermetic outer container, a hydrogen peroxide pouch, and a hydrogen peroxide solution in the solution chamber. The hermetic outer container includes a sterilization enclosure configured to receive the medical device. The hydrogen peroxide pouch includes a permeable membrane enclosing a solution chamber and is configured to be positioned in the sterilization enclosure of the outer container. The permeable membrane is configured to allow hydrogen peroxide vapor to diffuse from the solution chamber through the permeable membrane into the sterilization enclosure. |
| FILED | Friday, April 28, 2023 |
| APPL NO | 18/140881 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/208 (20130101) Original (OR) Class A61L 2202/24 (20130101) A61L 2202/122 (20130101) A61L 2202/181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271172 | White et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mississippi State University (Starkville, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark G. White (Spring Hill, Florida); Shetian Liu (Bartlesville, Oklahoma) |
| ABSTRACT | The present invention provides a novel process and system in which a mixture of carbon monoxide and hydrogen synthesis gas, or syngas, is converted into hydrocarbon mixtures composed of high quality gasoline components, aromatic compounds, and lower molecular weight gaseous olefins in one reactor or step. The invention utilizes a novel molybdenum-zeolite catalyst in high pressure hydrogen for conversion, as well as a novel rhenium-zeolite catalyst in place of the molybdenum-zeolite catalyst, and provides for use of the novel catalysts in the process and system of the invention. |
| FILED | Wednesday, April 19, 2023 |
| APPL NO | 18/303556 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/28 (20130101) B01J 29/26 (20130101) B01J 29/48 (20130101) B01J 29/076 (20130101) B01J 29/78 (20130101) B01J 29/084 (20130101) B01J 29/166 (20130101) B01J 29/7815 (20130101) Original (OR) Class B01J 29/7876 (20130101) B01J 37/0201 (20130101) B01J 2229/18 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 2/334 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/08 (20130101) C10L 3/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271840 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for the State University of New York (Buffalo, New York); Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gang Wu (Clarence Center, New York); Zhi Qiao (Amherst, New York); Jacob Spendelow (Santa Fe, New Mexico); Chenyu Wang (Los Alamos, New Mexico); Dongguo Li (Los Alamos, New Mexico); Yung-Tin Pan (East Dist., Hsinchu City, Taiwan) |
| ABSTRACT | Provided are graphitic carbon materials and methods of making graphitic carbon materials. Also provided are compositions of the graphitic carbon materials with nanoparticles disposed thereon and methods of making the compositions. Also disclosed are devices utilizing the graphitic carbon materials and/or the compositions. The graphitic carbon materials are porous and have a desirable graphitic content. The graphitic materials may be nitrogen- and/or metal-doped. The nanoparticles may be platinum or platinum/transition metal nanoparticles. The compositions may be used in oxygen reduction reaction applications. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 18/005723 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/205 (20170801) Original (OR) Class C01B 32/215 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/52 (20130101) C01P 2002/74 (20130101) C01P 2006/12 (20130101) C01P 2006/14 (20130101) C01P 2006/16 (20130101) C01P 2006/40 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 11/054 (20210101) C25B 11/065 (20210101) C25B 11/081 (20210101) C25B 11/089 (20210101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/366 (20130101) H01M 4/587 (20130101) H01M 4/926 (20130101) H01M 8/1004 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272184 | Babuska et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Lehigh University (Bethlehem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tomas Farley Babuska (Albuquerque, New Mexico); Andrew Kustas (Elizabeth, Colorado); Tomas Grejtak (Bethlehem, Pennsylvania) |
| ABSTRACT | Polytetrafluoroethylene filled with FeCo microparticles provides an ultralow wear, magnetic, multifunctional tribological material. For example, PTFE filled with an 5 wt. % of equiatomic, prealloyed FeCo powder resulted in steady state wear rates of 2.7×10−7 mm3/Nm, approaching that of PTFE-filled alumina. Comparable wear rates were not recovered for PTFE filled with just iron or cobalt microparticles. |
| FILED | Wednesday, April 12, 2023 |
| APPL NO | 18/133826 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 114/26 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/11 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272202 | Hartwig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents Of The University Of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John F. Hartwig (Berkeley, California); Liye Chen (Berkeley, California) |
| ABSTRACT | Disclosed herein, inter alia, are oxidized polyethylene compounds and compositions and methods of making the same. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/921520 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/06 (20130101) C08F 4/80 (20130101) C08F 8/06 (20130101) C08F 110/02 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/3432 (20130101) Compositions of Macromolecular Compounds C08L 23/06 (20130101) C08L 23/30 (20130101) Original (OR) Class C08L 2207/066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272232 | Bell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nelson S. Bell (Albuquerque, New Mexico); Timothy J. Boyle (Albuquerque, New Mexico) |
| ABSTRACT | The use of copper materials as a replacement for the more expensive coinage metals (i.e., silver, gold) in printed circuits has come to the forefront. For printing, the use of nanomaterials has allowed for significant advances through the use of nanoinks. Unfortunately, as the nanoregime is entered, the increased surface area leads to increased reactivity with atmospheric oxygen which results in a reduction in the conductivity of the printed circuits. To overcome this issue, a synthesis method uses a room temperature reduction of a copper organometallic precursor by the simple addition of catechol-based surfactants to prevent oxidation and agglomeration of the final copper nanoparticles. The selection of these catechol-based surfactants is based on non-aqueous solubility, high surface affinity, and anti-oxidative potential as surface ligands. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/105973 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 1/102 (20220101) B22F 9/24 (20130101) B22F 2301/10 (20130101) B22F 2302/45 (20130101) B22F 2304/05 (20130101) B22F 2998/10 (20130101) B22F 2999/00 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/64 (20130101) Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black; C09C 1/627 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/037 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272272 | Jordan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the city of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abraham J Jordan (New York, New York); Jonathan S. Owen (New York, New York); Rodolphe Valleix (New York, New York); Lilian Guillemeny (New York, New York) |
| ABSTRACT | The disclosure provides processes for preparing etched quantum dots comprising Group II-VI and/or III-V elements. The processes include etching Group II-VI or III-V element quantum dots with an organic fluoride agent or ammonium salt and optionally shelling the etched quantum dots. The disclosure also provides processes for generating light from these quantum dots and devices, stains, or labels comprising the quantum dots prepared as described herein. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160700 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 11/025 (20130101) Original (OR) Class C09K 11/615 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272296 | Sumant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Anirudha V. Sumant (Plainfield, Illinois); Venkata Aditya Ayyagari (Darien, Illinois) |
| ABSTRACT | A low friction wear surface with a coefficient of friction in the superlubric regime under a sliding and rolling movement. The low friction wear surface includes molybdenum disulfide and graphene oxide on a first wear surface with a tribolayer formed on a rough steel counter surface during the sliding and rolling movement. Methods of producing the low friction wear surface are also provided. |
| FILED | Friday, June 18, 2021 |
| APPL NO | 17/351817 |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 103/02 (20130101) C10M 103/06 (20130101) Original (OR) Class C10M 2201/0413 (20130101) C10M 2201/0663 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2050/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272542 | REN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Zhifeng REN (Pearland, Texas); Fang YU (Houston, Texas); Haiqing ZHOU (Houston, Texas); Shuo CHEN (Houston, Texas) |
| ABSTRACT | An electrode and system for electrocatalytic water splitting. The electrode for overall water splitting comprises a conductive substrate, and a bifunctional electrocatalyst comprising primarily metallic phosphides disposed on a surface of the substrate. The system comprises an anode and a cathode. Each of the anode and the cathode comprises a uniform distribution of a bifunctional electrocatalyst comprising metallic phosphides on a conductive substrate. The metallic phosphides can comprise iron phosphide (FeP) and dinickel phosphide (Ni2P). The bifunctional electrocatalyst promotes hydrogen evolution reaction (HER) at the cathode, and oxygen evolution reaction (OER) at the anode. |
| FILED | Thursday, May 04, 2023 |
| APPL NO | 18/311974 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/18 (20130101) C23C 16/30 (20130101) C23C 16/045 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 11/061 (20210101) C25B 11/075 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272927 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric KOZUBAL (Superior, Colorado); Jason David WOODS (Boulder, Colorado); Eric Jason BONNEMA (Littleton, Colorado); Ramin Teimouri FARAMARZI (Pacific Palisades, California) |
| ABSTRACT | A system comprising a first plurality of microchannels, a second plurality of microchannels in thermal communication with the first plurality of microchannels such that the first plurality of microchannels and second plurality of microchannels form a heat exchanger, and a phase change composite in thermal communication with the heat exchanger and methods of operating are disclosed herein. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/165401 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 5/001 (20130101) F24F 5/0021 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273076 | Berkland et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF KANSAS (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cory Berkland (Wildwood, Missouri); Jonathan Whitlow (Hutchinson, Kansas); Jean Salash (Overland Park, Kansas) |
| ABSTRACT | Disclosed are functional materials for use in additive manufacturing (AM). The functional material can comprise an elastomeric composition (e.g., a silicone composite) for use in, for example, direct ink writing. The elastomeric composition can include and elastomeric resin, and a magnetic nanorod filler dispersed within the elastomeric resin. Nanorod characteristics (e.g., length, diameter, aspect ratio) can be selected to create 3D-printed constructs with desired mechanical properties along different axes. Furthermore, since nickel nanorods are ferromagnetic, the spatial distribution and orientation of nanorods within the continuous phase can be controlled with an external magnetic field. This level of control over the nanostructure of the material system offers another degree of freedom in the design of functional parts and components with anisotropic properties. Magnetic fields can be used to remotely sense compression of the constructs, or alternatively, control the stiffness of these materials. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901380 |
| CURRENT CPC | Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2509/08 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/037 (20130101) C09D 11/102 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/12 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273167 | Versteeg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roelof Versteeg (Hanover, New Hampshire); Yuxin Wu (El Cerrito, California) |
| ABSTRACT | Disclosed herein are methods, systems, and devices for rhizosphere imaging. Methods include applying a signal to a portion of a plant and its roots via at least one first electrode, receiving the signal via at least one second electrode placed a designated distance from the plant, and generating, using one or more processors, a rhizosphere model based, at least in part, on the received signal, the generating of the rhizosphere model being implemented based, at least in part, on one or more frequency characteristics of the received signal. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 18/018204 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/02 (20130101) G01N 27/327 (20130101) G01N 33/0098 (20130101) Original (OR) Class Electric Digital Data Processing G06F 3/00 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 65/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273310 | Fernandes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Justin L. Fernandes (Kennewick, Washington); Douglas L. McMakin (Richland, Washington); David M. Sheen (Richland, Washington); Jonathan R. Tedeschi (Richland, Washington); Thomas E. Hall (Kennewick, Washington) |
| ABSTRACT | Methods and apparatus for scanning articles, such as footwear, to provide information regarding the contents of the articles are described. According to one aspect, a footwear scanning system includes a platform configured to contact footwear to be scanned, an antenna array configured to transmit electromagnetic waves through the platform into the footwear and to receive electromagnetic waves from the footwear and the platform, a transceiver coupled with antennas of the antenna array and configured to apply electrical signals to at least one of the antennas to generate the transmitted electromagnetic waves and to receive electrical signals from at least another of the antennas corresponding to the electromagnetic waves received by the others of the antennas, and processing circuitry configured to process the received electrical signals from the transceiver to provide information regarding contents within the footwear. |
| FILED | Monday, July 24, 2017 |
| APPL NO | 15/658111 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/41 (20130101) G01S 13/89 (20130101) G01S 13/887 (20130101) Original (OR) Class Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/12 (20130101) G01V 8/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273474 | Ghosh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Souvik Ghosh (Boulder, Colorado); Ivan Smalyukh (Boulder, Colorado) |
| ABSTRACT | Assemblies and methods for modulating (e.g., near) infrared radiation are provided. Exemplary assemblies include a composite material interposed between a first substrate and a second substrate. The composite material includes plasmonic nanoparticles (e.g., nanoplates) dispersed in a nematic liquid crystal. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/114782 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/56 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/1334 (20130101) Original (OR) Class Transmission Systems for Measured Values, Control or Similar Signals G08C 23/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230274174 | BIENER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JUERGEN BIENER (Castro Valley, California); HARTMUT HAEFFNER (Berkeley, California); CLEMENS MATTHIESEN (Cambridge, United Kingdom); ELI MEGIDISH (Albany, California); JAMES SPENCER OAKDALE (Castro Valley, California); XIAOXING XIA (Pleasanton, California) |
| ABSTRACT | A vertical ion trap include at least four RF electrodes on a substrate, the RF electrodes extending up from the substrate, a region between the electrodes forming the vertical ion trap, and at least two direct current electrodes adjacent the RF electrodes and the vertical ion trap. A horizontal ion traps includes a substrate, the substrate having a hole, at least one RF electrodes raised above the substrate and offset from each other across the hole, the RF electrodes, and at least one DC electrode corresponding to each RF electrode, the DC electrodes raised above the substrate. A method of forming an ion trap includes forming three-dimensional structures on a substrate in a curable polymer using two-photon polymerization direct laser writing, metalizing the three-dimensional structures to form RF electrodes, and forming direct current electrodes at least partially on the substrate. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 18/005393 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230274349 | Speirs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Solstice Initiative, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Koo Speirs (Somerville, Massachusetts); Sandhya Murali (Weston, Massachusetts); Sruthi Sujani Davuluri (Chicago, Illinois); Chikara Onda (Loveland, Colorado); Christopher R. Knittel (Lexington, Massachusetts) |
| ABSTRACT | The present invention provides predictive models for assessing an applicant's risk of defaulting on shared utility service bill payment, such as bill payment for community solar. Described are several alternatives to using FICO score to assess risk. Such alternatives include machine learning techniques (such as random forest classifier) as well as regression analysis. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/769561 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 40/12 (20131203) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230274405 | Grodsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachel Leigh Grodsky (Raymore, Missouri); Richard Brow (Rolla, Missouri); Melissa Malone Teague (Albuquerque, New Mexico) |
| ABSTRACT | A tamper-evident glass and methods of using the tamper-evident glass are provided herein. The tamper-evident glass comprising at least a first plurality of tamper-evident elements, which may be unique or near unique to each manufacturing of tam per-evident glass. The initial state of tamper-evident glass and positioning of the plurality of tamper-evident elements may be mapped through digital scanning to create a digital file of the current state of the tamper-evident glass. The tamper-evident glass may be scanned again to create a new digital file for comparison and to determine if a tampering event has occurred. The tamper-evident elements may include any combination of inorganic fluorescent material, crystals grown through nucleation and crystallization, or added colorants. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/174958 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230274858 | KADIYALA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AMPeers LLC (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janakiram Kaushal KADIYALA (Kakinada, India); Eduard Galstyan (Houston, Texas) |
| ABSTRACT | A superconductor wire can achieve a Je of at least 600 A/mm2 at 4.2 K, 20 T applied magnetic field, which is greater than Je previously reported in the literature. The superconductor wire can include superconductor tape stands that have Ic per total strand width of at least 125 A/mm at 4.2 K, 20 T applied magnetic field. In an embodiment, the superconductor wire can have superconductor film with a modified REBCO composition, where (Ba+M)/Cu is at least 0.72. In the same or different embodiment, the superconductor film can have a thickness of at least 3 microns. The superconductor tape strands can have a stabilizer layer, where the thickness of the stabilizer is selected so that the neutral plane of the strands is near or passes through the superconductor film. A superconductor cable can be made from superconductor wires. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/173978 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 12/06 (20130101) Original (OR) Class Electric solid-state devices not otherwise provided for H10N 60/857 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275218 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Apple Inc. (Cupertino, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dapeng Wang (Cupertino, California); Huiming Wu (San Jose, California); Hongli Dai (Los Altos, California); Xiaoping Wang (Naperville, Illinois); James Gilbert (Bolingbrook, Illinois); John David Carter (Bolingbrook, Illinois); Zhenzhen Yang (Godfrey, Illinois); Anh Vu (Lemont, Illinois); Yan Li (Westmont, Illinois); Yanjie Cui (Arlington Heights, Illinois); Christopher S. Johnson (Naperville, Illinois); Arthur Jeremy Kropf (Westmont, Illinois); Hakim H. Iddir (Hoffman Estates, Illinois) |
| ABSTRACT | Cathode active materials are provided. The cathode active material can include a plurality of cathode active compound particles. A coating is disposed over each of the cathode active compound particles. The coating can include at least one of ZrO2, La2O3, a mixture of Al2O3 and ZrO2 or a mixture of Al2O3 and La2O3. The battery cells that include the cathode active material are also provided. |
| FILED | Thursday, May 04, 2023 |
| APPL NO | 18/312474 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 51/50 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/84 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) Original (OR) Class H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/628 (20130101) H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275238 | Beck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor Alfred Beck (Livermore, California); Sarah Baker (Dublin, California); Swetha Chandrasekaran (Livermore, California); Eric Duoss (Livermore, California); Jean-Baptiste Forien (Livermore, California); Anna Nikolaevna Ivanovskaya (Mountain View, California); Marcus Worsley (Hayward, California) |
| ABSTRACT | Disclosed are flow-through electrode devices and techniques for making flow-through electrodes. In one aspect, a flow through electrode apparatus comprises one or more fiber layers. Each fiber layer comprises a plurality of fibers oriented to be orthogonal to a flow direction of a fluid. The plurality of fibers are configured to cause an inertial flow of the fluid around the plurality of fibers at a first flow rate of the fluid. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692870 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8626 (20130101) Original (OR) Class H01M 8/188 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275240 | BROWN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Versa Power Systems Ltd. c/o FuelCell Energy, Inc. (Danbury, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Casy Cloudless BROWN (Calgary, Canada); Khun Bong LUC (Calgary, Canada); Cameron James RANKIN (Calgary, Canada) |
| ABSTRACT | A base plate assembly for an electrochemical cell stack includes a bottom end plate defining a fuel inlet port, a fuel outlet port, and an oxidant port. The base plate assembly further includes a high strength sealing plate including openings that align with the fuel inlet port, the fuel outlet port, and the oxidant port, and a plurality of tubes located between the bottom end plate and the high strength sealing plate. The tubes are configured to yield to reduce transfer of mechanical stress from the high strength sealing plate to the bottom end plate. |
| FILED | Tuesday, April 18, 2023 |
| APPL NO | 18/302695 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/026 (20130101) Original (OR) Class H01M 8/0271 (20130101) H01M 8/2432 (20160201) H01M 8/2475 (20130101) H01M 8/2485 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275272 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Zhengcheng Zhang (Naperville, Illinois); Noah Mark Johnson (Westmont, Illinois) |
| ABSTRACT | An electrochemical device includes an electrolyte having a hydroxamate or N-hydroxyamide compound. |
| FILED | Wednesday, April 12, 2023 |
| APPL NO | 18/133668 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 259/10 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/054 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 2300/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275492 | Antao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dion S. Antao (College Station, Texas); Shiyu Zhang (Bryan, Texas); Dorsa Talebi (College Station, Texas); Matthew C. Gardner (Dallas, Texas); Sri Vignesh Sankarraman (Dallas, Texas) |
| ABSTRACT | A heatsink for an electric motor, the heatsink comprising a heat spreader configured to be placed in proximity to a winding of the electric motor, a channel formed through the heat spreader and comprising a coolant inlet and a coolant outlet, and a surface feature formed into a back face of the heat spreader that faces the winding and is configured to reduce eddy currents induced in the heatsink. |
| FILED | Saturday, February 25, 2023 |
| APPL NO | 18/114247 |
| CURRENT CPC | Dynamo-electric Machines H02K 9/227 (20210101) Original (OR) Class H02K 21/24 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/2039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275963 | Cintuglu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hitachi Energy Switzerland AG (Baden, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mehmet H. Cintuglu (Raleigh, North Carolina); Dmitry Ishchenko (Cary, North Carolina) |
| ABSTRACT | Systems, methods, techniques and apparatuses of asynchronous communication is distributed systems are disclosed. One exemplary embodiment is a method determining, with a plurality of agent nodes structured to communicate asynchronously in a distributed system, a first set of iterations including an iteration determined by each of the plurality of agent nodes; determining, with a first agent node of the plurality of agent nodes, a local vector clock; receiving, with the first agent node, a first iteration of the first set of iterations and a remote vector clock determined based on the first iteration; updating, with the first agent node, the local vector clock based on the received remote vector clock; and determining a first iteration of a second set of iterations based on the first set of iterations after determining all iterations of the first set of iterations have been received based on the local vector clock. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311571 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/1095 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230276564 | Kutsaev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RADIABEAM TECHNOLOGIES, LLC (Santa Monica, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergey Kutsaev (Santa Monica, California); Ronald Agustsson (Venice, California); Alexander Smirnov (Santa Monica, California) |
| ABSTRACT | A high gradient linear accelerating structure can propagate high frequency waves at a negative harmonic to accelerate low-energy ions. The linear accelerating structure can provide a gradient of 50 MV/m for particles at a β of between 0.3 and 0.4. The high gradient structure can be a part of a linear accelerator configured to provide an energy range from an ion source to 450 MeV/u for 12C6+ and 250 MeV for protons. The linear accelerator can include one or more of the following sections: a radiofrequency quadrupole (RFQ) accelerator operating at the sub-harmonic of the S-band frequency, a high gradient structure for the energy range from ˜45 MeV/u to ˜450 MeV/u. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/069108 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/001 (20130101) H05H 7/12 (20130101) Original (OR) Class H05H 9/045 (20130101) H05H 2007/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230270415 | Barnes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Ronald A. Barnes (San Antonio, Texas); Hope T. Beier (San Antonio, Texas); Bennett L. Ibey (San Antonio, Texas); Caleb Roth (San Antonio, Texas) |
| ABSTRACT | An acoustic imaging system responsive to an acoustic wave emitted from an object is disclosed. The system detects a deflection angle of an electromagnetic probe beam as it passes through a coupling element. The coupling element also couples the acoustic wave emitted from the object to an acoustic detector. The probe beam deflection angle is related to an angle of propagation of the acoustic wave through the coupling element. A filtering unit is configured to remove components of the signal from the acoustic detector that are outside of a range of angles, thereby improving the angular resolution of the acoustic detector. The acoustic wave may be generated by an acoustic source, such as an ultrasound transmitter, or an electromagnetic source such as a laser. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/821303 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/54 (20130101) A61B 8/5223 (20130101) Original (OR) Class A61B 8/5269 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270444 | FONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Certus Critical Care, Inc. (Salt Lake City, Utah); Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel FONG (Sacramento, California); Timothy WILLIAMS (Winston-Salem, North Carolina); Patrick Ryan KOLBAY (Salt Lake City, Utah); David POISNER (Carmichael, California); Michael Austin JOHNSON (Holladay, Utah); Lucas NEFF (Winston-Salem, North Carolina); Kobi IKI (San Carlos, California) |
| ABSTRACT | A method for calibrating at least one solid-state sensor coupled to an elongate body comprising an expandable member is described herein. In some variations, the method may include advancing the expandable member to a target location in a blood vessel of a patient, injecting a calibration bolus into the expandable member, obtaining, using a controller, a first sensor data from an expandable member sensor, obtaining, using the controller, a second sensor data from the at least one solid-state sensor, and adjusting the second sensor data based on the first sensor data. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/157759 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0215 (20130101) A61B 17/12136 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/10182 (20131105) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270767 | Deb |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arjun Deb (Los Angeles, California) |
| ABSTRACT | Disclosed herein are methods for inhibiting ectopic calcification in soft tissues, such as heart tissue. Also provided herein are ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) inhibitors. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100342 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/216 (20130101) A61K 31/663 (20130101) Original (OR) Class A61K 31/7076 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 19/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270795 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California); Technion Research and Development Foundation Ltd. (Haifa, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Li (La Jolla, California); Scott Peterson (La Jolla, California); Linda Bradley (La Jolla, California); Roberto Tinoco (La Jolla, California); Ze`ev Ronai (San Diego, California); Shiri Ashkenazi (Haifa, Israel) |
| ABSTRACT | The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103166 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/733 (20130101) A61K 31/7004 (20130101) A61K 31/7008 (20130101) A61K 31/7024 (20130101) A61K 35/74 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270881 | Bhatnagar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanchita Bhatnagar (Davis, California); Jogender Tushir-Singh (Davis, California) |
| ABSTRACT | Methods for sensitizing tumors and/or cancers in subjects to therapeutic agents are provided. In some embodiments, the methods include administering to the subject one or more compositions that include an effective amount of an inhibitor of TRIM37 activity. Also provided are methods for sensitizing tumors and/or cancers in subjects to therapeutic agents by administering to the subjects one or more compositions that include an effective amount of an inhibitor of TRIM37 activity and purified and isolated antibodies and fragments thereof that have at least one paratope and further have a linker sequence through which the antibody can be conjugated to a carrier in which the linker sequence includes the amino acid sequence ((X)3Cys(X)3, wherein each X is independently any amino acid. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/794432 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6849 (20170801) A61K 47/6913 (20170801) Original (OR) Class A61K 47/6915 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271731 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Anderson (Colorado Springs, Colorado); Grant Appel (O'Fallon, Illinois); Nathaniel Bowen (Columbus, Mississippi); Hugh Briggs (Colorado Springs, Colorado); Spencer Flint (Seattle, Washington); Seth Konig (Biloxi, Mississippi); Erin Leslie (Oklahoma City, Oklahoma) |
| ABSTRACT | A method of establishing a system for gathering surveillance data in a hostile environment. The method comprises the steps of providing a movable tractor for ground hauling a trailer, and providing a drone which can be operated independently from the tractor. The trailer has a floor pan for supporting a relay sensor dispensing mechanism and a platform above the floor pan, with a hole for dispensing relay sensors therethrough. The relay sensor dispensing mechanism has an elevator for holding a stockpile of relay sensors, and elevating the relay sensors through the hole. The method comprises disposing at least one relay sensor in the elevator, elevating the relay sensor to a pickup position at or above the platform and retrieving the relay sensor with a drone for subsequent deposition in the hostile environment. The relay sensor then gathers and transceives surveillance data for use and interpretation by an operator. Optional a conveyor chute may replenish the elevator when it is depleted of relay sensors. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/822481 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 1/38 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 10/00 (20230101) Original (OR) Class B64U 2101/60 (20230101) Systems for Controlling or Regulating Non-electric Variables G05D 1/101 (20130101) G05D 2201/0207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272038 | Levin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Noam Levin (Rockville, Maryland); Rami Yoseph (Gaithersburg, Maryland); Gal Cafri (Kibbutz Nir David, Israel); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glycine at position 12 with aspartic acid. The TCRs may recognize G12D RAS presented by an HLA-DR heterodimer. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 18/015776 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) A61K 39/4632 (20230501) A61K 39/464464 (20230501) Peptides C07K 14/7051 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5748 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272335 | Hashemi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Nastaran Hashemi (Ames, Iowa); Reza Montazami (Ames, Iowa); Marilyn Christine McNamara (Ames, Iowa); Jasmin Okuzono (Ames, Iowa) |
| ABSTRACT | Various embodiments disclosed relate to conductive graphene matrix-encapsulated cells. A matrix-encapsulated cell includes an encapsulating polymer matrix including a biopolymer and graphene. The matrix-encapsulated cell also includes one or more of the cells encapsulated within the encapsulating polymer, wherein the graphene directly contacts at least some of the cells. The matrix encapsulating the one or more cells is electrically conductive. |
| FILED | Tuesday, May 09, 2023 |
| APPL NO | 18/195017 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/19 (20170801) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272446 | PARMEGGIANI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fabio PARMEGGIANI (Seattle, Washington); TJ BRUNETTE (Seattle, Washington); Po-Ssu HUANG (Seattle, Washington); David BAKER (Seattle, Washington) |
| ABSTRACT | Methods and systems for designing proteins are disclosed, as well as proteins and protein assemblies designed. A computing device can determine a protein repeating unit that includes one or more protein helices and one or more protein loops. The computing device can generate a protein backbone structure with a copy of the protein repeating unit. The computing device can determine whether a distance between a pair of helices of the protein backbone structure is between lower and upper distance thresholds. After determining that the distance between the pair of helices is between the lower and upper distance thresholds, the computing device can: generate a plurality of protein sequences based on the protein backbone structure, select a particular protein sequence of the plurality of protein sequences based on an energy landscape that has information about energy and distance from a target fold of the particular protein sequence, and generate an output based on the particular protein sequence. |
| FILED | Friday, May 05, 2023 |
| APPL NO | 18/312788 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 2800/101 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272450 | Rininsland et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mesa Photonics, LLC (Santa Fe, New Mexico) |
| ASSIGNEE(S) | Mesa Photonics, LLC (Santa Fe, New Mexico) |
| INVENTOR(S) | Frauke Henrike Rininsland (Santa Fe, New Mexico); Daniel James Kane (Santa Fe, New Mexico) |
| ABSTRACT | The present invention relates to a method for detecting a pathogen in cellular lysate by measuring pathogen-specific enzyme activity. The method comprises contacting the cellular lysate with a substrate the pathogen of interest recognizes and modifies, and obtaining a measurable, recordable, signal. The method may comprise detection of SARS-CoV viruses using the activity of SARS PLpro enzyme in tongue scrape lysate as a readout. |
| FILED | Sunday, February 05, 2023 |
| APPL NO | 18/105864 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2333/9513 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272466 | ISMAGILOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. ISMAGILOV (Altadena, California); Jacob T. BARLOW (Pasadena, California); Said R. BOGATYREV (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems for absolute quantification of a target 16S rRNA and/or of a target prokaryotic taxon, based on amplifying and sequencing a same 16S rRNA recognition segment in which target 16S rRNA conserved regions flank 16S rRNA variable regions, conserved and variable among a plurality of sample 16S rRNAs and/or of a sample prokaryotic taxon of higher taxonomic rank with respect to the target taxon. In the methods and systems, absolute abundance of the a plurality of sample 16S rRNAs and/or of the sample prokaryotic taxon detected by the amplifying, is multiplied by the relative abundance of the target 16S rRNA and/or of a target prokaryotic taxon detected by the sequencing to provide the absolute quantification in accordance with method and systems of the disclosure. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863183 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272539 | Roberts et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army DEVCOM Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony J. Roberts (Chesapeake City, Maryland); Anit K. Giri (Abingdon, Maryland); Billy C. Hornbuckle (Bel Air, Maryland); Kristopher A. Darling (Havre de Grace, Maryland) |
| ABSTRACT | A method and apparatus for generating hydrogen gas by reacting a nanogalvanic alloy with water vapor. The apparatus comprises a water vapor source for supplying water vapor to a reaction chamber containing a nanogalvanic alloy. The nanogalvanic alloy reacts with the water vapor to produce hydrogen. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682501 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/042 (20210101) Original (OR) Class C25B 11/046 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273077 | Thevamaran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); Wesleyan University (Middletown, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramathasan Thevamaran (Madison, Wisconsin); Jizhe Cai (Madison, Wisconsin); Tsampikos Kottos (Farmington, Connecticut); Fred Ellis (Middletown, Connecticut); Rodion Kononchuk (Meriden, Connecticut) |
| ABSTRACT | One or more computing devices, systems, and/or methods are provided. In an example, a method includes tuning a sensor comprising a first resonator having an effective gain, a second resonator having an effective loss, and a coupling circuit connected between the first resonator and the second resonator at an extrema degeneracy point with a nonlinear response to a force applied to the sensor. At least one of the first resonator, the second resonator, or the coupling circuit comprises a variable capacitor having a capacitance that varies as a function of the force. The method comprises injecting an input signal into one of the first resonator or the second resonator, receiving an output signal from one of the first resonator or the second resonator, and determining a magnitude of a force based on a difference between a first frequency extrema point and a second frequency extrema point in the output signal. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/681320 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/142 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230274128 | Ross et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isaac Michael Ross (Monterey, California); Mark Karpenko (Salinas, Maryland) |
| ABSTRACT | A method, apparatus and system including the execution of an accelerated optimization method. According to an exemplary embodiment, the accelerated optimization method includes: first-order optimality conditions for a generic nonlinear optimization problem are generated as part of the terminal transversality conditions of an optimal control problem. It is shown that the Lagrangian of the optimization problem is connected to the Hamiltonian of the optimal control problem via a zero-Hamiltonian, infinite-order, singular arc. The necessary conditions for the singular optimal control problem are used to produce an auxiliary controllable dynamical system whose trajectories generate algorithm primitives for the optimization problem. A three-step iterative map for a generic algorithm is designed by a semi-discretization step. Neither the feedback control law nor the differential equation governing the algorithm need be derived explicitly. A search direction is produced by a proximal-aiming-type method that dissipates a control Lyapunov function. New step size procedures based on minimizing control Lyapunov functions along a search vector complete the design of the accelerated optimization algorithms. |
| FILED | Friday, February 03, 2023 |
| APPL NO | 18/105494 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0464 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230274156 | HAMERLY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ryan HAMERLY (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); NTT Research, Incorporated (Sunnyvale, California) |
| INVENTOR(S) | Ryan HAMERLY (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | NetCast is an optical neural network architecture that circumvents constraints on deep neural network (DNN) inference at the edge. Many DNNs have weight matrices that are too large to run on edge processors, leading to limitations on DNN inference at the edge or bandwidth bottlenecks between the edge and server that hosts the DNN. With NetCast, a weight server stores the DNN weight matrix in local memory, modulates the weights onto different spectral channels of an optical carrier, and distributes the weights to one or more clients via optical links. Each client stores the activations, or layer inputs, for the DNN and computes the matrix-vector product of those activations with the weights from the weight server in the optical domain. This multiplication can be performed coherently by interfering the spectrally multiplexed weights with spectrally multiplexed activations or incoherently by modulating the weight signal from the weight server with the activations. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 18/247129 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/098 (20230101) Original (OR) Class G06N 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275224 | Allen |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jan L. Allen (Silver Spring, Maryland) |
| ABSTRACT | A composition of matter and method includes Li1+x+zM(II)0.5−2x−zM(III)x+yM(IV)1.5−2y−z M(V)yM(V)zO4. M(II) includes any of Mg, Co, Ni, Cu, and Zn. M(III) includes any of Al, Cr, Fe, Ga, and In. M(IV) includes any of Ti, Mn, and Ge. M(V) includes any of Nb, Ta, Sb, and Bi. Additionally, 0≤x≤0.25, 0≤y≤0.75, 0≤z≤0.5, and (x+z)>0. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/133191 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) H01M 4/0471 (20130101) H01M 4/505 (20130101) Original (OR) Class H01M 4/525 (20130101) H01M 10/0562 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275741 | DACHMAN-SOLED et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NTT RESEARCH INC. (Sunnyvale, California) |
| ASSIGNEE(S) | NTT RESEARCH INC. (Sunnyvale, California) |
| INVENTOR(S) | DANA DACHMAN-SOLED (COLLEGE PARK, Maryland); ILAN KOMARGODSKI (Tel Aviv, Israel); RAFAEL N PASS (New York, New York) |
| ABSTRACT | Systems, methods, network devices, and machine-readable media disclosed herein include encoding data for storage or transmission by encoding the data according to a tamper-resistant data encoding scheme that renders the data secure against unbounded polynomial size attacks. The present disclosure further includes subsequently determining whether the data has been tampered with, and notifying a processor when the data has been modified or compromised. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/012226 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/005 (20130101) Original (OR) Class H04L 9/3218 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230276171 | Ayazi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Farrokh Ayazi (Atlanta, Georgia); Pranav Gupta (Atlanta, Georgia); Yaesuk Jeong (Atlanta, Georgia) |
| ABSTRACT | Small form-factor MEMS devices and methods of using the devices. An exemplary MEMS device includes an ACM. Certain devices comprise nanometer scale sensing gaps in the out-of-plane direction to increase vibration sensitivity in a vacuum casing. Certain devices described herein provide a differential sensing mechanism. Accelerometer contact microphones having an operational bandwidth ranging from 0 Hz and 10,000 Hz are also disclosed. The vibration acceleration sensitivity of certain devices described herein is better 100 μg√Hz. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311264 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 7/02 (20130101) B81B 2201/0235 (20130101) B81B 2201/0257 (20130101) B81B 2203/04 (20130101) B81B 2203/0154 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/097 (20130101) G01P 15/125 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/04 (20130101) H04R 1/46 (20130101) Original (OR) Class H04R 19/04 (20130101) H04R 2201/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230270127 | Harte et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Federico Miguel Harte (Port Matilda, Pennsylvania); Marta Corzo Martinez (Madrid, Spain); Maneesha S. Mohan (University Park, Pennsylvania) |
| ABSTRACT | Provided are methods for processing milk using one or more procedures that include at least one high pressure treatment, such as High Pressure Jet Processing at a hydrostatic pressure of at least 400 MPs. Food additives and food products that contain processed milk components are also provided, and may be dairy or non-dairy products. |
| FILED | Monday, May 08, 2023 |
| APPL NO | 18/313584 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1524 (20130101) Original (OR) Class A23C 2210/15 (20130101) A23C 2210/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272395 | RICIGLIANO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by The Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | VINCENT A. RICIGLIANO (BATON ROUGE, Louisiana); MICHAEL SIMONE-FINSTROM (BATON ROUGE, Louisiana); JAMES G. THOMSON (EL CERRITO, California) |
| ABSTRACT | The present disclosure provides recombinant microalgae that can deliver both pathogen protection and essential nutrition to honey bees. The microalgae can contain genetic modifications that result in the expression of RNA-interference (RNAi) inducing elements that target honey bee pathogens and endogenous honey bee genes. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/175394 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/60 (20200101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Fodder A23K 10/16 (20160501) A23K 20/153 (20160501) A23K 50/90 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272407 | van Oosterwijk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Biologic, Inc. (Memphis, Tennessee); The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | US Biologic, Inc. (Memphis, Tennessee); The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Jolieke Gerdy van Oosterwijk (Memphis, Tennessee); Luciana Meirelles Richer (Memphis, Tennessee); Douglas Steven Zatechka (Cordova, Tennessee); Woohyun Kim (Ellicott city, Maryland); Hyun Soon Lillehoj (West Friendship, Maryland); Cyril Gray (Bethesda, Maryland); Christopher Anthony Przybyszewski (Southhaven, Mississippi) |
| ABSTRACT | The inventive subject matter includes an antimicrobial peptide vectored composition made of a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules. More specifically these novel recombinant antimicrobial peptide effector molecules exhibit preferential anti¬microbial activity. The utility of the current inventive subject matter has demonstrated a reduced viability of Eimeira acervulina sporozoites in vitro using a sporozoite killing assay. More specifically, the antimicrobial peptide vectored composition is a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules, wherein the one or more recombinant antimicrobial peptide effector molecules are engineered from a NK-lysin gene and the one or more recombinant antimicrobial peptide effector molecules are engineered to express functionally active NK-2. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 18/008512 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/742 (20130101) Peptides C07K 14/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/75 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272413 | HECK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MICHELLE L. HECK (ITHACA, New York); JENNIFER R. WILSON (ITHACA, New York); CARL J. SCHILTZ (JOELTON, Tennessee); JOSHUA S. CHAPPIE (ITHACA, New York); MYFANWY C. ADAMS (ITHACA, New York) |
| ABSTRACT | Disclosed herein are plant-based, molecular and diagnostic tools that can be used to block aphid transmission of poleroviruses, including stabilized proteins for expression in transgenic plants and/or in formulations for direct plant delivery. Further disclosed are proteins that can kill aphids and methods to produce these proteins. Antibodies and useful for diagnostic and therapeutic uses against poleroviruses. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/066191 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Peptides C07K 14/005 (20130101) C07K 16/10 (20130101) C07K 2317/569 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/8286 (20130101) Original (OR) Class C12N 2770/00021 (20130101) C12N 2770/00022 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230272490 | ZHAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiangchao ZHAO (Fayetteville, Arkansas); Jianmin CHAI (Fayetteville, Arkansas); Elizabeth B. KEGLEY (Springdale, Arkansas); Jeremy POWELL (Lowell, Arkansas) |
| ABSTRACT | Sets of bacterial features were identified in the nostrils, nasopharynx, and lungs of cows that can be used to predict the likelihood that a cow will develop bovine respiratory disease (BRD) or to diagnose BRD. The present invention provides methods and kits for selecting cows to treat for BRD based on the levels of these biomarkers in the respiratory microbiome. Using these methods and kits, producers may selectively treat cows deemed to be at risk for BRD, saving money and decreasing antibiotic use. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 18/020241 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0051 (20130101) Veterinary Instruments, Implements, Tools, or Methods A61D 99/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230274136 | Zwolak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justyna Pytel Zwolak (Point of Rocks, Maryland); Sandesh Sachin Kalantre (College Park, Maryland); Jacob Mason Taylor (Cambridge, Massachusetts); Thomas Walter McJunkin (Madison, Wisconsin) |
| ABSTRACT | A ray-based classifier apparatus tunes a device using machine learning and includes: a machine learning module including a training data generator module and produces a device state; and the autotuning module including: a recognition module and a measurement module and that produces recognition data based on the device state and ray-based data; a comparison module that produces comparison data; a prediction module that produces prediction data for the device; a gate voltage controller that produces controller data and device control data and controls the device with the device control data; and a measurement module that produces ray-based data, such that the recognition module performs recognition on the ray-based data using the device state. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 18/028154 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230274375 | Zuckerman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CFPH, LLC (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Zuckerman (Chappaqua, New York) |
| ABSTRACT | According to various embodiments, systems and methods are provided for enabling parties to create, define, buy, and sell usage rights in radio frequency (RF) ranges, e.g., via a computerized trading exchange. The usage rights may comprise exclusive or shared ownership or lease interests. A government or other entity may initially offer on the exchange usage rights in radio frequencies owned or controlled by the government. The usage rights may be sold to market participants, e.g., through a competitive bidding process such as a reverse auction, Dutch auction, RFQ, or other methodology. Such rights may be transferred subject to government use, e.g., in emergency situations. Information associated with offered RF usage rights such as historical usage data, geographical reach, and available RF equipment may be published on the exchange. The exchange may also enable secondary trading of usage rights. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/141726 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/38 (20130101) G06Q 30/06 (20130101) G06Q 50/26 (20130101) G06Q 50/184 (20130101) Original (OR) Class G06Q 50/188 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230275741 | DACHMAN-SOLED et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NTT RESEARCH INC. (Sunnyvale, California) |
| ASSIGNEE(S) | NTT RESEARCH INC. (Sunnyvale, California) |
| INVENTOR(S) | DANA DACHMAN-SOLED (COLLEGE PARK, Maryland); ILAN KOMARGODSKI (Tel Aviv, Israel); RAFAEL N PASS (New York, New York) |
| ABSTRACT | Systems, methods, network devices, and machine-readable media disclosed herein include encoding data for storage or transmission by encoding the data according to a tamper-resistant data encoding scheme that renders the data secure against unbounded polynomial size attacks. The present disclosure further includes subsequently determining whether the data has been tampered with, and notifying a processor when the data has been modified or compromised. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/012226 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/005 (20130101) Original (OR) Class H04L 9/3218 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230271150 | Yates et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Yates (South Barrington, Illinois); Amanda Childers (Arlington Heights, Illinois); Mehrad Mehr (Morristown, New Jersey); Jeffrey Spencer (Gilbert, Arizona); Jason Smoke (Phoenix, Arizona); Abigail Parsons (South Bend, Indiana) |
| ABSTRACT | A thermal process system includes a retort assembly, a heating assembly, and a vessel housing. The retort assembly includes a retort chamber and is configured to substantially form a containment boundary to contain one or more gases in the retort chamber during a thermal process. The heating assembly includes one or more heating elements and is configured to heat the retort chamber. The vessel housing is positioned around the retort chamber and the one or more heating elements and configured to form a pressure boundary to maintain a pressure within the retort chamber and reduce a pressure across the retort chamber. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/931441 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 6/008 (20130101) Original (OR) Class Non-metallic Elements; Compounds Thereof; C01B 3/24 (20130101) C01B 2203/0272 (20130101) C01B 2203/1241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271181 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Michael D. Geuy (State College, Pennsylvania); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A fluidic device includes a fluidic chip having a fluidic network comprising a plurality of fluidic channels in fluidic communication with a plurality of input ports, at least one output port, and at least one sensing port; and an actuator configured to engage with the fluidic network to control each fluidic channel to switch between an open state in which fluidic flow through said fluidic channel is permitted and a closed state in which no fluidic flow through said fluidic channel is permitted, so as to selectively collect fluid from multiple inputs via the plurality of input ports, and direct either all of the multiple inputs to the at least one output port, or all but a single selected input to the at least one output port and the single selected input to the at least one sensing port to which an analytical instrument is operably connected. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 18/015749 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271865 | YEH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (TAMPA, Florida); UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel H. YEH (Tampa, Florida); Melanie T. PICKETT (Tampa, Florida); Luke ROBERSON (Orlando, Florida); Jorge L. CALABRIA (Tampa, Florida); Talon BULLARD (Tampa, Florida) |
| ABSTRACT | A closed-loop, bioregenerative water purification system including a gravity-independent anaerobic membrane bioreactor capable of operating in the presence and absence of gravity, the bioreactor including an anaerobic bioreactor, a first membrane filtration unit, and a second membrane filtration unit, wherein the anaerobic bioreactor is configured to receive organic waste and hygiene water as inputs and break them down into constituent components using anaerobic microbes, wherein the first membrane filtration unit is configured to receive effluent output from the anaerobic bioreactor, return concentrate to the anaerobic bioreactor, and output permeate to the second membrane filtration unit, and wherein the second membrane filtration unit is configured to receive the permeate output from the first membrane filtration unit, separate biogas from the permeate, and output nutrient-rich water. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 18/011031 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 31/00 (20130101) Separation B01D 19/0031 (20130101) B01D 53/229 (20130101) B01D 61/145 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/2853 (20130101) C02F 9/00 (20130101) Original (OR) Class Organic Fertilisers Not Covered by Subclasses C05B, C05C, e.g Fertilisers From Waste or Refuse C05F 3/04 (20130101) C05F 7/00 (20130101) C05F 17/40 (20200101) C05F 17/80 (20200101) C05F 17/971 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230270842 | Schrader et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VAXESS TECHNOLOGIES, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | VAXESS TECHNOLOGIES, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael A. Schrader (Watertown, Massachusetts); Kathryn M. Kosuda (Cambridge, Massachusetts); Jonathan A. Kluge (Cambridge, Massachusetts); Kimberly M. Cirelli (Brookline, Massachusetts); Emily L. Borkowski (Somerville, Massachusetts); Cassie L. Caudill (Watertown, Massachusetts); Matthew Dirckx (Medford, Massachusetts); Nickolas W. Hartman (Houston, Texas); Livio Valenti (Cambridge, Massachusetts) |
| ABSTRACT | Microneedle and microneedle devices including implantable tips (e.g., silk-based tips) for sustained dermal delivery of a coronavirus and/or influenza vaccine, kits, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for controlled- or sustained-administration of a coronavirus vaccine and/or an influenza vaccine to provide improved immunogenicity and/or broad-spectrum immunity to a subject are also described. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991525 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) A61K 39/145 (20130101) A61K 39/215 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230271234 | Campanella et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| ASSIGNEE(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| INVENTOR(S) | Andrew Campanella (Somerville, Massachusetts); Joseph G. Michels (New York, New York); Peter Quigley (Duxbury, Massachusetts); Ian Martin (Sharon, Massachusetts) |
| ABSTRACT | A control system for controlling extraction of landfill gas, comprising: at least one sensor configured to measure one or more characteristics of landfill gas; at least one flow control mechanism disposed in well piping and configured to control flow of the landfill gas through the well piping; and at least one processor configured to: obtain a measured concentration of a first gas in landfill gas; determine whether the measured concentration of the first gas is either less than a first threshold concentration or greater than a second threshold concentration; when it is determined that the measured concentration is less than the first threshold concentration, control the at least one flow control mechanism to reduce flow rate of landfill gas; and when it is determined that the concentration is greater than the second threshold concentration, control the at least one flow control mechanism to increase the flow rate of landfill gas. |
| FILED | Tuesday, February 14, 2023 |
| APPL NO | 18/168983 |
| CURRENT CPC | Disposal of Solid Waste B09B 1/006 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230273571 | DeLacy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ballydel Technologies, Inc. (Wilmington, Delaware) |
| ASSIGNEE(S) | Ballydel Technologies, Inc. (Wilmington, Delaware) |
| INVENTOR(S) | Brendan G. DeLacy (Wilmington, Delaware); Mark S. Mirotznik (Wilmington, Delaware); Benjamin S. Garrett (Wilmington, Delaware) |
| ABSTRACT | A computerized system for uniquely tagging and verifying authenticity of an article comprising: an object having a curvature; a computer system adapted to: receive a three-dimensional predetermined image, create a holographic interference pattern created according to the three-dimensional predetermined image and the curvature wherein the holographic interference pattern is applied to the object, project a three-dimensional resulting image projected on a planar surface in response to the holographic interference pattern being illuminated wherein the computer system receives the three-dimensional resulting image, create validation information according to a comparison of the three-dimensional predetermined image and the three-dimensional resulting image |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/176269 |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/0011 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/88 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230270739 | Siegel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The United States Government as Represented by the Department of Veterans Affairs (810 Vermont Ave., NW, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerome Siegel (Porter Ranch, California); Ronald McGregor (Sherman Oaks, California); Ming-Fung Frank Wu (Porter Ranch, California) |
| ABSTRACT | Disclosed herein are compositions and methods for treating subjects for pain with opioids while reducing or inhibiting their risk of opioid addiction. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/925775 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/485 (20130101) Original (OR) Class A61K 31/5513 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230270776 | Neuwelt |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Edward A. Neuwelt (Portland, Oregon) |
| ABSTRACT | Described herein is a method for eliminating or reducing ototoxicity in patients receiving a platinum based chemotherapeutic. In particular, are methods of reducing ototoxicity in a pediatric patient. The methods described herein include administering an effective amount of sodium thiosulfate to a patient in need thereof to reduce ototoxicity. |
| FILED | Tuesday, May 09, 2023 |
| APPL NO | 18/195296 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/04 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230274081 | Fan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arlen Fan (Phoenix, Arizona); Yuxin Ma (Shenzhen, China PRC); Ross Maciejewski (Phoenix, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Arlen Fan (Phoenix, Arizona); Yuxin Ma (Shenzhen, China PRC); Ross Maciejewski (Phoenix, Arizona) |
| ABSTRACT | The present disclosure describes examples of a computer-implemented framework that helps to detect deception in charts and/or associated articles through textual and visual annotations. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106926 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/30 (20200101) G06F 40/169 (20200101) Original (OR) Class Image or Video Recognition or Understanding G06V 30/1444 (20220101) G06V 30/19173 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Executive Office of the President (EOP)
| US 20230274375 | Zuckerman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CFPH, LLC (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Zuckerman (Chappaqua, New York) |
| ABSTRACT | According to various embodiments, systems and methods are provided for enabling parties to create, define, buy, and sell usage rights in radio frequency (RF) ranges, e.g., via a computerized trading exchange. The usage rights may comprise exclusive or shared ownership or lease interests. A government or other entity may initially offer on the exchange usage rights in radio frequencies owned or controlled by the government. The usage rights may be sold to market participants, e.g., through a competitive bidding process such as a reverse auction, Dutch auction, RFQ, or other methodology. Such rights may be transferred subject to government use, e.g., in emergency situations. Information associated with offered RF usage rights such as historical usage data, geographical reach, and available RF equipment may be published on the exchange. The exchange may also enable secondary trading of usage rights. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/141726 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/38 (20130101) G06Q 30/06 (20130101) G06Q 50/26 (20130101) G06Q 50/184 (20130101) Original (OR) Class G06Q 50/188 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20230275741 | DACHMAN-SOLED et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NTT RESEARCH INC. (Sunnyvale, California) |
| ASSIGNEE(S) | NTT RESEARCH INC. (Sunnyvale, California) |
| INVENTOR(S) | DANA DACHMAN-SOLED (COLLEGE PARK, Maryland); ILAN KOMARGODSKI (Tel Aviv, Israel); RAFAEL N PASS (New York, New York) |
| ABSTRACT | Systems, methods, network devices, and machine-readable media disclosed herein include encoding data for storage or transmission by encoding the data according to a tamper-resistant data encoding scheme that renders the data secure against unbounded polynomial size attacks. The present disclosure further includes subsequently determining whether the data has been tampered with, and notifying a processor when the data has been modified or compromised. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/012226 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/005 (20130101) Original (OR) Class H04L 9/3218 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, August 31, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230831.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page