FedInvent™ Patent Applications
Application Details for Thursday, September 07, 2023
This page was updated on Thursday, September 07, 2023 at 05:31 PM GMT
Department of Health and Human Services (HHS)
| US 20230276802 | Swale et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State Universtiy and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State Universtiy and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Daniel R. Swale (High Springs, Florida); Lane D. Foil (Baton Rouge, Louisiana) |
| ABSTRACT | Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or elimination in the ability of the arthropod to feed. Administering Kir channel inhibitors reduces food intake, increases feeding time, reduces salivary gland secretion, induces mortality, and reduces transmission of vector-borne pathogens. Kir channel inhibitors induce these adverse effects in ticks, mosquitoes, horn flies, and aphids. |
| FILED | Thursday, April 20, 2023 |
| APPL NO | 18/136974 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/38 (20130101) A01N 43/40 (20130101) Original (OR) Class A01N 43/56 (20130101) A01N 43/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277052 | PLESHKO et al. |
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| APPLICANT(S) | Temple University-Of The Commonwealth System Of Higher Education (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Nancy PLESHKO (Cherry Hill, New Jersey); Shital Kandel (Philadelphia, Pennsylvania); Jessica M. Falcon (New York, New York); William Querido-Maciel (Philadelphia, Pennsylvania); Jack Oswald (Melrose Park, Pennsylvania) |
| ABSTRACT | An arthroscopic probe system comprises a spectrometer, a computing system connected to the spectrometer and an arthroscopic probe device comprising a probe shaft including a proximal end and probe tip positioned at a distal end, a handle including a proximal end and a distal end, wherein the distal end of the handle is connected to the proximal end of the probe shaft, a cable including a first end and a second end, wherein the first end is connected to the proximal end of the handle, and at least one optical fiber, wherein a first end of the at least one optical fiber is optically connected to the probe tip, wherein the at least one optical fiber is positioned internally to the probe shaft, handle and cable, and wherein a second end of the at least one optical fiber terminates at the second end of the cable. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/175854 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/07 (20130101) A61B 1/00096 (20130101) A61B 1/317 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277068 | Siefkes et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oaklarnd, California) |
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| INVENTOR(S) | Heather Siefkes (Davis, California); Satyanarayana Lakshminrusimha (Davis, California); Chen-Nee Chuah (Davis, California); Zhengfeng Lai (Davis, California) |
| ABSTRACT | Disclosed are systems and methods for classifying heart defects using a predictive model based on a set of parameters that includes oxygen saturation (Sp02), perfusion index (PIx), heart rate (HR) data, radiofemoral delay, and/or photoplethysmography (PPG) slope. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/919159 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/026 (20130101) A61B 5/0205 (20130101) Original (OR) Class A61B 5/681 (20130101) A61B 5/02416 (20130101) A61B 5/6829 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) A61B 5/14551 (20130101) A61B 2503/045 (20130101) Computer Systems Based on Specific Computational Models G06N 20/10 (20190101) G06N 20/20 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277080 | Khademhosseini et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Alireza Khademhosseini (Los Angeles, California); Shiming Zhang (Los Angeles, California); Zhikang Li (Los Angeles, California) |
| ABSTRACT | A gelatin methacryloyl (GelMA)-based biosensor device for wearable biosensing applications is disclosed. An exemplary capacitive tactile sensor with GelMA used as the core dielectric layer is disclosed. A robust chemical bonding and a reliable encapsulation approach are introduced to overcome detachment and water-evaporation issues in hydrogel biosensors. The resultant GelMA tactile sensor shows a high-pressure sensitivity of 0.19 kPa−1 and one order of magnitude lower limit of detection (0.1 Pa) compared to previous hydrogel pressure sensors owing to its excellent mechanical and electrical properties (e.g., dielectric constant). Furthermore, it shows durability up to 3,000 test cycles because of tough chemical bonding, and long-term stability of three (3) days due to the inclusion of an encapsulation layer, which prevents water evaporation (e.g., 80% water content). Successful monitoring of various human physiological and motion signals demonstrates the potential of the GelMA biosensor device for wearable biosensing applications. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 18/040115 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/024 (20130101) A61B 5/053 (20130101) Original (OR) Class A61B 5/681 (20130101) A61B 2562/12 (20130101) A61B 2562/0247 (20130101) Compositions of Macromolecular Compounds C08L 89/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277095 | MUJEEB-U-RAHMAN et al. |
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| APPLICANT(S) | Integrated Medical Sensors, Inc. (Irvine, California) |
| ASSIGNEE(S) | Integrated Medical Sensors, Inc. (Irvine, California) |
| INVENTOR(S) | MUHAMMAD MUJEEB-U-RAHMAN (IRVINE, California); MEISAM HONARVAR NAZARI (IRVINE, California); MEHMET SENCAN (TUSTIN, California) |
| ABSTRACT | There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (I) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/093532 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/6849 (20130101) A61B 5/14532 (20130101) Original (OR) Class A61B 5/14865 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277120 | Wilson et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Robert Wilson (Irvine, California); Wei Jin (Irvine, California); Rebecca Rowland (San Anselmo, California); Gordon Kennedy (Irvine, California); Anthony Durkin (Irvine, California); Sahil Ahuja (Irvine, California) |
| ABSTRACT | The disclosure provides methods for accurately quantifying optical properties of skin in subjects that have varying skin tones, and applications thereof. |
| FILED | Saturday, March 04, 2023 |
| APPL NO | 18/117422 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/443 (20130101) Original (OR) Class A61B 5/445 (20130101) A61B 5/7221 (20130101) A61B 5/7246 (20130101) A61B 5/14551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277159 | ZHAO et al. |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
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| INVENTOR(S) | Xuanhe ZHAO (Cambridge, Massachusetts); Xiaoyu CHEN (Cambridge, Massachusetts); Chonghe WANG (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods are provided for on-person wearable electronic devices configured for extended periods of wear. A couplant may be provided that is made of a soft anti-dehydrating, and hydrogel-elastomer hybrid material. A bioadhesive may connect the couplant the electronic devices and the person. The couplant may serve as a coupling and transmission for information to or from the electronic device. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/117738 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4236 (20130101) Original (OR) Class A61B 8/4494 (20130101) A61B 2562/12 (20130101) A61B 2562/164 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277293 | Tranquillo et al. |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
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| INVENTOR(S) | Robert Tranquillo (Arden Hills, Minnesota); Zeeshan Syedain (Minneapolis, Minnesota); Lee Meier (Minneapolis, Minnesota) |
| ABSTRACT | This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/117930 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/04 (20130101) A61F 2/06 (20130101) Original (OR) Class A61F 2/062 (20130101) A61F 2/2412 (20130101) A61F 2/2415 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/36 (20130101) A61L 27/507 (20130101) A61L 27/3604 (20130101) A61L 27/3633 (20130101) A61L 27/3695 (20130101) A61L 2430/40 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 23/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277456 | Peruzzi et al. |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Justin Alexander Peruzzi (Evanston, Illinois); Neha Prashant Kamat (Evanston, Illinois); Jan Steinkuehler (Evanston, Illinois) |
| ABSTRACT | The present disclosure provides methods and compositions for controlling the localization of proteins in lipid structures. The disclosure also provides methods for selecting appropriate proteins for desired localization and distribution in lipid structures based on hydrophobic thickness. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 18/054131 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) Original (OR) Class A61K 9/1275 (20130101) A61K 9/1278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277472 | XIE |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
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| INVENTOR(S) | Jin XIE (Watkinsville, Georgia) |
| ABSTRACT | Disclosed are particles comprising lithium salts and methods for their use in treating inflammatory conditions. |
| FILED | Friday, April 07, 2023 |
| APPL NO | 18/297365 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 9/5161 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277483 | Hong et al. |
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| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
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| INVENTOR(S) | Liu Hong (Coralville, Iowa); Jeff Banas (Solon, Iowa); Ling Yang (Coralville, Iowa); Min Zhu (Iowa City, Iowa); Yi Shu (Chongqing, China PRC) |
| ABSTRACT | A composition comprising an amount of one or more agents comprising a hydroxy(C1-10)(COOH) or salt thereof, wherein C1-10 can be substituted or form a ring, a dicarboxylic acid, a purine nucleoside or analog thereof, a pyrimidine nucleoside or an analog thereof, or an amino acid or analog thereof, effective to inhibit inflammation, and methods of using the composition, are provided. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/110094 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) Original (OR) Class A61K 47/54 (20170801) A61K 47/64 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) A61P 3/04 (20180101) A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277503 | Foster et al. |
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| APPLICANT(S) | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (Baton Rouge, Louisiana) |
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| INVENTOR(S) | Timothy Paul Foster (Slidell, Louisiana); Charles David Nichols (New Orleans, Louisiana) |
| ABSTRACT | This invention is directed to compositions, methods and kits for ameliorating or reducing pathogenesis of a disease by administering to a subject a serotonin receptor agonist. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/984011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/48 (20130101) A61K 31/137 (20130101) A61K 31/4045 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 31/22 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277512 | GEISSMANN et al. |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
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| INVENTOR(S) | Frederic GEISSMANN (New York, New York); Elvira MASS (New York, New York); Rocio VICARIO (New York, New York) |
| ABSTRACT | The present technology relates to methods for treating, preventing, and/or ameliorating kinase mutation-associated neurodegenerative diseases, including BRAFV600E-associated neurodegenerative diseases, in a subject in need thereof. In particular aspects, the present technology relates to the use of BRAF, MEK, and/or CSF-1R inhibitors to treat, prevent, and/or ameliorate kinase mutation-associated neurodegenerative diseases, including BRAFV600E-associated neurodegenerative diseases. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751226 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277528 | Hu |
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| APPLICANT(S) | WASHINGTON UNIVERSITY (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Hongzhen Hu (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of compositions and methods for treating hair regeneration disorders or conditions such as hair loss or thinning. An aspect of the present disclosure provides for a method of treating hair loss, promoting hair growth, or treating hair loss, such as alopecia or telogen effluvium, comprising administering a TRPV4 activating agent to a subject. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 18/009050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/4965 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277549 | Deng et al. |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Meng Deng (West Lafayette, Indiana); Di Huang (Malden, Massachusetts); Shihuan Kuang (West Lafayette, Indiana) |
| ABSTRACT | Provided is the use of Notch signaling inhibitors such as γ-secretase inhibitors (GSIs), which increase expression of uncoupling protein-1 (UCP-1), to selectively increase browning of white adipose tissue, for example, in the treatment of obesity and metabolic disorders such as type 2 diabetes mellitus (T2DM), fatty liver disease, atherosclerosis, and others, including comorbidities thereof. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 18/017384 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 31/19 (20130101) A61K 31/55 (20130101) Original (OR) Class A61K 31/417 (20130101) A61K 31/4245 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277550 | Axelrod et al. |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
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| INVENTOR(S) | Jeffrey Axelrod (Stanford, California); Carlos Milla (Stanford, California); Eszter Vladar (Stanford, California) |
| ABSTRACT | Abstract: The invention therefore provides methods of treating a respiratory disease characterized by mucus hyper-secretion comprising administering to a human patient in need of such treatment a gamma secretase inhibitor (GSI), wherein the administration of a GSI is effective in reducing mucus in such patient’s lungs or inhibiting mucus accumulation in said patient’s lungs. In some embodiments, the methods of the invention are effective in treating a respiratory disease selected from the group consisting of cystic fibrosis, chronic obstructive pulmonary disease, primary ciliary dyskinesis, chronic bronchitis, asthma, idiopathic and secondary bronchiectasis, bronchiolitis obliterans, idiopathic pulmonary fibrosis and other fibrotic lung disorders, respiratory infection including exacerbations in chronic respiratory disorders, and mucus accumulation in response to acute infection. Methods of the invention further include methods of treating cystic fibrosis wherein a GSI is administered to a patient being administered or in need of a CFTR modulator, wherein the mucus in such patient’s lungs is reduced or mucus accumulation in such patient’s lungs is inhibited. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 18/018999 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/55 (20130101) Original (OR) Class A61K 31/105 (20130101) A61K 31/4164 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277559 | Purves et al. |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Todd Purves (Durham, North Carolina); Francis Hughes (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods for the treatment of inflammation in urological pathologies. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/146665 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/64 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/24 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277569 | Altieri |
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| APPLICANT(S) | THE WISTAR INSTITUTE (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Dario C. Altieri (Philadelphia, Pennsylvania) |
| ABSTRACT | Described herein is a method of treating, ameliorating and/or preventing cancer in a subject in need thereof. The method includes administering to the subject therapeutically effective amounts of Gamitrinib according to one of certain specific administration schemes (protocols). Also described herein is a kit for performing the methods of the disclosure. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/115945 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) Original (OR) Class A61K 47/20 (20130101) A61K 47/24 (20130101) A61K 47/26 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277570 | Li et al. |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingyin Li (Stanford, California); Mark Smith (Stanford, California); Kelsey Erin Shaw (Stanford, California); Jacqueline Ann Carozza (Stanford, California); Volker Boehnert (Stanford, California) |
| ABSTRACT | Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a ENPP1 inhibitor to inhibit cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor is cell impermeable. Also provided are compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of a ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject either before or after administering an ENPP1 inhibitor. The radiation therapy can be administered at a dosage and/or frequency effective to reduce radiation damage to the subject. In certain cases, the method is performed in combination with a chemotherapeutic agent, or a checkpoint inhibitor, or both. |
| FILED | Tuesday, May 16, 2023 |
| APPL NO | 18/197877 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277574 | Chen et al. |
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| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zheng-Yi Chen (Somerville, Massachusetts); Wenyan Li (Boston, Massachusetts); Yi-Zhou Quan (Dorchester, Massachusetts) |
| ABSTRACT | Compositions for regeneration of inner cells and for treating hearing loss comprise at least one modulator of mechanistic target of rapamycin (mTOR) sufficient to induce reprogramming proliferation and regeneration of inner ear cells. The composition include, in some instances, an effective amount of one or more phosphatase and tensin homolog (PTEN) inhibitors, MYC/NOTCH modulators, Atonal Homolog 1 (Atoh1) modulators or combinations thereof. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154474 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/365 (20130101) A61K 31/7028 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277577 | Hirano et al. |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michio Hirano (New York, New York); Caterina Garone (Cambridge, United Kingdom); Ramon Marti (Barcelona, Spain) |
| ABSTRACT | The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome. |
| FILED | Monday, April 24, 2023 |
| APPL NO | 18/138432 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/513 (20130101) A61K 31/708 (20130101) A61K 31/7068 (20130101) A61K 31/7072 (20130101) Original (OR) Class A61K 31/7076 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277580 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Liu (Chapel Hill, North Carolina); Jine Li (Chapel Hill, North Carolina); Guowei Su (Durham, North Carolina); Rafal Pawlinski (Chapel Hill, North Carolina); Erica Sparkenbaugh (Chapel Hill, North Carolina) |
| ABSTRACT | Chondroitin sulfate compounds comprising chondroitin sulfate backbone 19 mer, CS-A 19 mer, CS-C 19 mer, CS-E 19 mer, CS backbone 13 mer, CS-A 13 mer, CS-C 13 mer, CS-E 13 mer and/or combinations thereof are provided. Methods of treating histone toxicity in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the histone toxicity in the subject. Pharmaceutical compositions for use in treating histone toxicity and/or sepsis are provided. Methods of treating sepsis in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the sepsis in the subject. |
| FILED | Monday, April 24, 2023 |
| APPL NO | 18/138596 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/737 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277583 | Martin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia); Hillhurst Biopharmaceuticals, Inc. (Montrose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pamela Martin (Evans, Georgia); Ravirajsinh Jadeja (Evans, Georgia); Andrew Gomperts (San Diego, California) |
| ABSTRACT | Enteral formulations containing including therapeutically effective amount carbon monoxide, and methods of use thereof, for treatment of ocular diseases and disorders are provided. The formulations can be administered in a subject in need thereof in an effective amount to reduce or prevent an ocular disease in the subject, and thus reduce one or more symptoms of disease, disorder, or illness associated with the disease. In some embodiments, the formulation is administered orally. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/179069 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/00 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277586 | Barrett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Terrence Barrett (Lexington, Kentucky); Samuel Awuah (Lexington, Kentucky) |
| ABSTRACT | A method of increasing mitochondrial respiration in a cell makes use of a compound having the structure of formula (I) or formula (II). |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 18/006889 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/242 (20190101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277599 | Galipeau et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacques Galipeau (Madison, Wisconsin); Raghavan Chinnadurai (Tucker, Georgia) |
| ABSTRACT | This disclosure relates to methods of preserving mesenchymal stromal/stem cells (MSCs) for use in clinical applications. In certain embodiments, this disclosure relates to methods of preserving MSCs comprising mixing MSCs with interferon-gamma prior to cryopreserving, freezing, or cooling the MSCs to a temperature below zero degrees Celsius. |
| FILED | Thursday, April 06, 2023 |
| APPL NO | 18/296923 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0215 (20130101) A01N 1/0221 (20130101) A01N 1/0226 (20130101) A01N 1/0284 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) C12N 2501/24 (20130101) C12N 2523/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277618 | Golub et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd Golub (Cambridge, Massachusetts); Daniel Bondeson (Cambridge, Massachusetts); Brenton Paolella (Cambridge, Massachusetts); Francisca Vazquez (Cambridge, Massachusetts) |
| ABSTRACT | The subject matter disclosed herein is generally directed to inhibition of XPR1 :KIDINS220-mediated phosphate export to treat cancer, in particular, ovarian and uterine cancers. The subject matter disclosed herein is also generally directed to determining cancer dependency on phosphate export by detecting the expression of SLC34A2. Compositions for inhibiting XPR1 :KIDINS220-mediated phosphate export are also described. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 18/019851 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/162 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 15/08 (20180101) A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277623 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong Feng Chen (Newtonville, Massachusetts); Chenying Guo (Malden, Massachusetts) |
| ABSTRACT | Disclosed is a method of promoting neuronal growth by administering IGFBPL-1, or an agent that increases or stabilizes IGFBPL-1 activity to a subject in need thereof, e.g., a subject in need of treating optic nerve degeneration. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/073951 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/352 (20130101) A61K 31/708 (20130101) A61K 31/711 (20130101) A61K 31/713 (20130101) A61K 31/7004 (20130101) A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 38/18 (20130101) Original (OR) Class A61K 38/22 (20130101) A61K 38/30 (20130101) A61K 38/1738 (20130101) A61K 38/1841 (20130101) A61K 38/2278 (20130101) A61K 45/06 (20130101) A61K 49/0056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277634 | Martino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cameron Martino (La Jolla, California); Benjamin Kellman (La Jolla, California); Nathan Lewis (La Jolla, California); Robin Knight (La Jolla, California); Jeffrey D. Esko (La Jolla, California); Daniel Sandoval (La Jolla, California); Thomas Mandel Clausen (La Jolla, California) |
| ABSTRACT | Methods and compositions for diagnosing, preventing or treating a viral infection in a subject comprising administering to a subject in need thereof an effective amount of a glycosidase or a sulfatase to degrade a glycan, such as heparan sulfate, to inhibit viral infection, such as COVID-19. Methods for identifying a glycosidase, a sulfatase, or a microbe associated with increased susceptibility to viral infection in a subject. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 18/005816 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 38/51 (20130101) Original (OR) Class A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) C12Q 1/34 (20130101) C12Q 1/527 (20130101) Enzymes C12Y 301/06013 (20130101) C12Y 301/06014 (20130101) C12Y 402/02007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277653 | MCLELLAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason MCLELLAN (Austin, Texas); Ching-Lin HSIEH (Austin, Texas) |
| ABSTRACT | Provided herein are engineered protein comprising stabilized coronavirus S protein ectodomains, such as stabilized SARS-CoV-2 S protein ectodomains. In some aspects, the engineered S protein ectodomains exhibit enhanced antigenicity. Methods are also provided for use of the engineered S protein ectodomains as diagnostics, in screening platforms, and/or in vaccine compositions. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061256 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277658 | QUIJANO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Elias QUIJANO (Durham, Connecticut); Adele RICCIARDI (New Haven, Connecticut); Raman BAHAL (Glastonbury, Connecticut); Audrey TURCHICK (Chelmsford, Massachusetts); Nicholas ECONOMOS (New Haven, Connecticut); W. Mark SALTZMAN (New Haven, Connecticut); Peter GLAZER (Guilford, Connecticut) |
| ABSTRACT | Compositions for improved gene editing and methods of use thereof are disclosed. In a preferred method, gene editing involves use of a cell-penetrating anti-DNA antibody, such as 3E10, as a potentiating agent to enhance gene editing by nucleases and triplex forming oligonucleotides. Genomic modification occurs at a higher frequency when cells are contacted with the potentiating agent and nuclease or triplex forming oligonucleotide, as compared to the absence of the potentiating agent. The methods are suitable for both ex vivo and in vivo approaches to gene editing and are useful for treating a subject with a genetic disease or disorder. Nanoparticle compositions for intracellular delivery of the gene editing compositions are provided and are particularly advantageous for use with in vivo applications. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 18/054101 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) A61K 31/7088 (20130101) A61K 35/28 (20130101) A61K 38/14 (20130101) A61K 38/465 (20130101) A61K 39/39533 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277682 | Nittoli |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regeneron Pharmaceuticals, Inc. (Tarrytown, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Nittoli (Orangeburg, New York) |
| ABSTRACT | Provided herein are verrucarin A derivatives, linker-verrucarin A derivatives and antibody drug conjugates thereof. In one embodiment, the verrucarin A derivatives, linker-verrucarin A derivatives and antibody drug conjugates are useful in treating viral diseases. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154262 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/65 (20170801) A61K 47/6803 (20170801) A61K 47/6841 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Heterocyclic Compounds C07D 493/20 (20130101) C07D 493/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277688 | Venditti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Charles P. Venditti (Potomac, Maryland); Jennifer L. Sloan (Silver Spring, Maryland) |
| ABSTRACT | The present invention provides a synthetic MMACHC polynucleotide comprising a polynucleotide encoding MMACHC that is codon-optimized for expression in a human. Also provided is a polypeptide encoded by a synthetic MMACHC polynucleotide, an expression vector comprising a MMACHC gene sequence under the control of a chicken beta actin (CBA) promoter, and an expression vector comprising a synthetic MMACHC polynucleotide. Methods of treating cobalamin C deficiency and for detecting or tracking exogenous MMACHC are also provided. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 18/056356 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/26 (20130101) A61K 48/0066 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Peptides C07K 14/435 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/85 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277690 | Amin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Salk Institute for Biological Studies (La Jolla, California) |
| ASSIGNEE(S) | Salk Institute for Biological Studies (La Jolla, California) |
| INVENTOR(S) | Neal Dilip Amin (La Jolla, California) |
| ABSTRACT | The present disclosure relates to nucleic acid promoter sequences that are able to specifically express genes operatively linked to the promoter in brainstem and spinal motor neuron cells, and to methods for using such promoters to selectively express genes in motor neurons in vitro and in vivo. It is based, at least in part, on the discovery that the nucleic acid of SEQ ID NO: 1 functioned as a motor neuron-specific promoter and was successful in expressing transgenes in motor neuron cells in vivo. The present disclosure also relates to compositions that can increase the activity or expression level of miR-218 and to compositions that can decrease the expression of miR-218 target nucleic acids. |
| FILED | Friday, April 07, 2023 |
| APPL NO | 18/297323 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 67/0276 (20130101) A01K 2217/052 (20130101) A01K 2217/075 (20130101) A01K 2227/50 (20130101) A01K 2227/105 (20130101) A01K 2267/0318 (20130101) A01K 2267/0393 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 48/0016 (20130101) A61K 48/0066 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2310/113 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277695 | LAKSHMANAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anupama LAKSHMANAN (Pasadena, California); Arash FARHADI (Pasadena, California); Suchita P. NETY (Sunnyvale, California); Raymond W. BOURDEAU (Watertown, Massachusetts); Mikhail SHAPIRO (Los Angeles, California) |
| ABSTRACT | Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046881 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/481 (20130101) A61B 8/5238 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 49/0045 (20130101) A61K 49/0093 (20130101) A61K 49/221 (20130101) A61K 49/223 (20130101) Original (OR) Class Peptides C07K 14/195 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277732 | Misra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Sanjay Misra (Rochester, Minnesota); Allan B. Dietz (Chatfield, Minnesota) |
| ABSTRACT | This document provides methods and materials involved in reducing venous neointimal hyperplasia (VNH) of an arteriovenous fistula (AVF) or graft. For example, methods and materials for using stem cells (e.g., mesenchymal stem cells), extracellular matrix material, or a combination of stem cells and extracellular matrix material to reduce VNH of AVFs or grafts are provided. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075919 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/28 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/507 (20130101) A61L 27/3633 (20130101) A61L 27/3834 (20130101) A61L 31/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277746 | Humes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); SEASTAR MEDICAL, INC. (CARDIFF-BY-THE-SEA, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | H. David Humes (Ann Arbor, Michigan); Deborah Buffington (Ann Arbor, Michigan) |
| ABSTRACT | The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/937632 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/34 (20130101) A61M 1/341 (20140204) A61M 1/3621 (20130101) A61M 1/3633 (20130101) A61M 1/3666 (20130101) A61M 1/3667 (20140204) A61M 1/3672 (20130101) A61M 1/3679 (20130101) A61M 1/3687 (20130101) Original (OR) Class A61M 2205/3331 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277767 | DiPIERRO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Morningside Venture Investments Limited (Newton Centre, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guy DiPIERRO (San Francisco, California); Alan Joel LEVY (Bellevue, Washington) |
| ABSTRACT | Optimized bio-synchronous drug delivery begins with establishing a bio-synchronous treatment protocol that incorporates individual temporal and innate biological characteristics into a pharmacological treatment plan. The bio-synchronous treatment protocol is thereafter initiated using bioactive agent delivery device. Bio-synchronous drug delivery includes continual collection of patient data such as physical, psychological, temporal and environmental characteristics. This data is analyzed so to not only determine an initial treatment protocol but to also determining whether modification to the ongoing bio-synchronous treatment protocol is required. And, responsive to determining a modification is required the system modifies the bio-synchronous treatment protocol and use of delivery device. These modifications and treatment protocols can include reactive and proactive psychological support supplied to the patient in a variety of formats. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/936750 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/30 (20130101) A61M 5/1723 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/63 (20180101) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277831 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Hong CHEN (St. Louis, Missouri); Zhongtao HU (St. Louis, Missouri); Si CHEN (St. Louis, Missouri); Yaoheng YANG (St. Louis, Missouri); Yan GONG (St. Louis, Missouri) |
| ABSTRACT | Devices, systems, and methods for performing focused ultrasound-mediated blood-brain barrier opening (FUS-BBBO) are disclosed. Focused ultrasound (FUS) devices are disclosed that include an adapter configured to attach to an actuated mounting shaft of a stereotaxic system, a transducer housing configured to mount to the adapter, and a FUS transducer housed within the transducer housing. A FUS system is disclosed that includes the disclosed FUS device operatively coupled to a transducer driving system. A stereotaxic-guided FUS-BBB system is disclosed that includes the disclosed FUS system mounted to an actuated mounting shaft of a stereotaxic system. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/179966 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0092 (20130101) Original (OR) Class A61M 2209/088 (20130101) A61M 2210/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278032 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Shaopeng WANG (Chandler, Arizona); Fenni ZHANG (Tempe, Arizona) |
| ABSTRACT | Disclosed herein is a system and method for quantitative detection and analysis of molecular binding kinetics of a substance with surface membrane proteins of a biological object, such as a live cell, based on detecting and tracking membrane fluctuation amplitude changes cause by membrane displacement associated with the binding of the substance with the surface membrane proteins. The molecular binding kinetics can be detected with high precision in real time from an optical image of the biological object with a differential detection method. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/174541 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2021/0106 (20130101) Image or Video Recognition or Understanding G06V 10/14 (20220101) G06V 10/25 (20220101) G06V 10/44 (20220101) G06V 10/62 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278976 | Boxley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Glycosurf, Inc. (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chett Boxley (Park City, Utah); Ryan Stolley (Salt Lake City, Utah); Robert Bruggeman (Salt Lake City, Utah) |
| ABSTRACT | Methods of forming a glycolipid are disclosed. A method may include glycosylating a sugar with a beta-hydroxyester using BF3-L as a glycosylation promoter. L may include one or more of Diethylether, Tetrahydrofurn, Dimethyle Sulfide, or combinations thereof. The beta-hydroxyester may include a carbon length ranging from C2 to C24. The sugar may be a protected sugar that includes peracetylated-rhamnose, peracetylated-xylose, peracetylated-glucose, peracetylated-galactose or combinations thereof. The beta-hydroxyester and sugar may be combined in a reaction vessel to form a mixture. A solvent may be added to the mixture to substantially dissolve the mixture. The glycosylation promoter may be added to the solution such that the solution is maintained withing a desired temperature range. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/858059 |
| CURRENT CPC | Heterocyclic Compounds C07D 309/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278987 | Sebahar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Curza Global, LLC (Salt Lake City, Utah); The University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul R. Sebahar (Sandy, Utah); Ryan E. LOOPER (Salt Lake City, Utah); Charles A. TESTA (North Salt Lake, Utah); Benlsaac C. TRESCO (Salt Lake City, Utah); Travis J. HAUSSENER (Salt Lake City, Utah); Hariprasada R. Kanna REDDY (Salt Lake City, Utah); Seth GRANT (West Jordan, Utah) |
| ABSTRACT | The application is directed to compounds that are active as antibacterial agents. The compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes for making the compounds. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/776580 |
| CURRENT CPC | Heterocyclic Compounds C07D 239/47 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) Original (OR) Class C07D 405/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279007 | Slaugenhaupt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); The United States of America, as Represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan A. Slaugenhaupt (Hingham, Massachusetts); Graham Johnson (Sanbornton, New Hampshire); William D. Paquette (Amsterdam, New York); Wei Zhang (Sharon, Massachusetts); Juan Marugan (Gaithersburg, Maryland) |
| ABSTRACT | Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided. |
| FILED | Friday, April 07, 2023 |
| APPL NO | 18/297569 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 405/12 (20130101) C07D 417/12 (20130101) C07D 471/04 (20130101) C07D 473/16 (20130101) C07D 473/34 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 495/04 (20130101) C07D 513/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279021 | Gandla et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AGENEBIO, INC. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deepa Gandla (Albany, New York); Brian Gregg (Albany, New York); Vishnumurthy Hegde (Glen Mills, Pennsylvania); Stephan D. Parent (West Lafayette, Indiana); Travis Lee Houston (Lafayette, Indiana) |
| ABSTRACT | Crystalline forms of a GABAA α5 agonist, pharmaceutical compositions and combinations comprising those crystalline forms, their use in methods of treating cognitive impairment associated with central nervous system (CNS) disorders, cognitive impairment associated with brain cancer, the brain cancer itself or Parkinson's disease psychosis and methods of producing the crystalline forms. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 18/015445 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/13 (20130101) A61K 31/5517 (20130101) A61K 45/06 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Heterocyclic Compounds C07D 487/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279048 | TSENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Biotissue Holdings Inc. (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scheffer TSENG (Pinecrest, Florida); Hua He (Miami, Florida); Suzhen Zhang (Miami, Florida); Ying-Tieng Zhu (Homestead, Florida) |
| ABSTRACT | Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 18/051796 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/191 (20130101) A61K 47/55 (20170801) A61K 47/69 (20170801) A61K 47/6957 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/34 (20130101) A61L 27/54 (20130101) A61L 29/16 (20130101) A61L 29/085 (20130101) A61L 31/10 (20130101) A61L 31/16 (20130101) Peptides C07K 1/36 (20130101) Original (OR) Class C07K 14/47 (20130101) C07K 14/525 (20130101) C07K 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279082 | Mouquet et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York); California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Hugo Mouquet (New York, New York); Michel Nussenzweig (New York, New York); Pamela J. Bjorkman (Altadena, California); Louise Scharf (Porter Ranch, California) |
| ABSTRACT | The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide. |
| FILED | Friday, April 07, 2023 |
| APPL NO | 18/297301 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) Peptides C07K 16/1045 (20130101) Original (OR) Class C07K 16/1063 (20130101) C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279084 | Marks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. Marks (Kensington, California); Maria Consuelo Garcia Rodriguez (San Francisco, California); Jianbo Dong (San Francisco, California); Zhengda Sun (San Francisco, California) |
| ABSTRACT | The present disclosure provides antibodies that specifically bind to botulinum neurotoxins. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used in methods to specifically bind and, in some embodiments, neutralize, botulinum neurotoxin and are therefore also useful in the treatment. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046751 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/1282 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/549 (20130101) G01N 33/563 (20130101) G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279086 | Singh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Singh Biotechnology, LLC (Lutz, Florida); The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| ASSIGNEE(S) | Singh Biotechnology, LLC (Lutz, Florida); The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| INVENTOR(S) | Sunanda Singh (Lutz, Florida); Charles E. Egwuagu (Silver Spring, Maryland) |
| ABSTRACT | The present invention provides methods of treating and preventing uveitis in a subject using a single-domain antibody (sdAb), wherein the sdAb comprises the amino acid sequence as set forth in SEQ ID NO:1. In one aspect, the subject is a mammal such as a human. In another aspect, the sbAb is used in combination with one or more compounds. The uveitis treated by the invention can be sympathetic ophthalmia, birdshot retinochoroidopathy, Behcet's disease, Vogt-Koyanagi-Harada disease and ocular sarcoidosis. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 17/859861 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 29/00 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279119 | Nishimura et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Stephen L. Nishimura (San Francisco, California); Anthony Cormier (San Francisco, California); Saburo Ito (San Francisco, California); Jianlong Lou (San Francisco, California); James D. Marks (San Francisco, California); Yifan Cheng (San Francisco, California); Melody G. Campbell (San Francisco, California); Jody L. Baron (San Francisco, California) |
| ABSTRACT | Antibodies that bind to αvβ8 are provided. |
| FILED | Wednesday, January 11, 2023 |
| APPL NO | 18/153103 |
| CURRENT CPC | Peptides C07K 16/2839 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279170 | Hua |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duy H. Hua (Manhattan, Kansas) |
| ABSTRACT | Synthesis of chiral polyvinylpyrrolidinone (CSPVP) compounds, complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and selective C—H bond oxidation reactions utilizing such complexes are disclosed. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177488 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/44 (20130101) B01J 23/52 (20130101) B01J 23/72 (20130101) B01J 35/0013 (20130101) B01J 37/0072 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 226/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279231 | Choi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hak Soo Choi (Needham, Massachusetts); Jonghan Kim (Cambridge, Massachusetts); Georges El Fakhri (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided. |
| FILED | Monday, May 15, 2023 |
| APPL NO | 18/197560 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 23/0025 (20130101) C09B 23/0033 (20130101) C09B 23/0041 (20130101) C09B 23/0066 (20130101) Original (OR) Class C09B 69/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279347 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Chun-Li Zhang (Coppell, Texas); Lei-Lei Wang (Dallas, Texas); Yuhua Zou (Coppell, Texas); Wenjiao Tai (Dallas, Texas); Wenze Niu (Dallas, Texas) |
| ABSTRACT | The present disclosure describes the use of ectopic SOX2 to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease, by reprogramming non-nerve cells into neuronal cells. In particular, the disclosure provides for the use of SOX2 therapy, optionally combined with neurogenic growth factors, to treat nerve deficit conditions. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 18/050687 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0623 (20130101) Original (OR) Class C12N 5/0657 (20130101) C12N 5/0662 (20130101) C12N 15/86 (20130101) C12N 2501/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279353 | Pelus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louis M. Pelus (Carmel, Indiana); Jonathan Hoggatt (Cambridge, Massachusetts) |
| ABSTRACT | The receptor EP4 is identified as the PGE2 receptor that is most responsible enhancing the homing and engraftment of hematopoietic stem and progenitor cells. Treatment of graft sources and graft recipients with compounds that preferentially target the EP4 receptor provide effective methods of increasing engraftment success while minimizing adverse side effects that may Obe associated with therapies that include the use of less selective molecules such as PGE2 and dmPGE2. One effective molecule used in such therapies is 5-[(1E,3R)-4,4-ditluoro-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone or a pharmaceutically acceptable salt thereof (L-902, 685). |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/959242 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 2501/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279359 | Chevalier et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett Chevalier (Malden, Massachusetts); Alexander Marson (San Francisco, California); Richard A. Young (Boston, Massachusetts); Ruth Foreman (Somerville, Massachusetts); Rudolf Jaenisch (Brookline, Massachusetts) |
| ABSTRACT | The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/091888 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/545 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) Original (OR) Class C12N 2501/415 (20130101) C12N 2501/602 (20130101) C12N 2501/603 (20130101) C12N 2501/604 (20130101) C12N 2502/45 (20130101) C12N 2502/99 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279362 | Collins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| INVENTOR(S) | Peter Collins (Kensington, Maryland); Ursula Buchholz (Silver Spring, Maryland) |
| ABSTRACT | Reported herein are novel recombinant respiratory syncytial viruses (RSV) having an attenuated phenotype. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/008393 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/155 (20130101) A61K 2039/543 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2760/18521 (20130101) C12N 2760/18534 (20130101) C12N 2760/18571 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279372 | STANFORD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristin STANFORD (Dublin, Ohio); Daniel GALLEGO PEREZ (Columbus, Ohio); Mark ZIOLO (Dublin, Ohio) |
| ABSTRACT | The present disclosure relates to compositions for regulating lipokines and methods of use thereof. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 18/018981 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/46 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) Original (OR) Class Enzymes C12Y 303/02003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279378 | Chatterjee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhishek Chatterjee (Lexington, Massachusetts); Katherine Grasso (Boston, Massachusetts) |
| ABSTRACT | The present invention describes methods to create chimeric aminoacyl-tRNA synthetases (aaRS) derived from bacteria which show optimal activity and high thermostability. These chimeric aaRSs can be more aggressively engineered to generate a wider assortment of Uaa-selective mutants that are stable at the physiological temperature. The invention further describes the composition of chimeric TyrRSs, generated from E. coli and G. stearothermophilus TyrRSs, which demonstrate enhanced stability relative to EcTyrRS and higher activity relative to both TyrRS enzymes. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/768408 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 9/93 (20130101) Original (OR) Class C12N 15/70 (20130101) Enzymes C12Y 601/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279379 | LENZINI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| INVENTOR(S) | STEPHEN LENZINI (CHICAGO, Illinois); JAE-WON SHIN (CHICAGO, Illinois) |
| ABSTRACT | A method and microfluidic device for increasing the production of extracellular vesicles are provided which include the use of a cell-adhesive substrate for culturing extracellular-vesicle-producing cells, wherein the cell-adhesive substrate is a hydrogel having a Young's modulus of about 0.1 kPa to about 5 kPa and the hydrogel is functionalized with one or more cell adhesive peptides. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/178736 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) C12M 47/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0662 (20130101) C12N 11/10 (20130101) Original (OR) Class C12N 2533/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279383 | Zhuang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Xiaowei Zhuang (Cambridge, Massachusetts); Kok-Hao Chen (Cambridge, Massachusetts); Alistair Boettiger (Cambridge, Massachusetts); Jeffrey R. Moffitt (Cambridge, Massachusetts); Siyuan Wang (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046409 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) C07H 21/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/1065 (20130101) Original (OR) Class C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6837 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 25/20 (20190201) G16B 30/00 (20190201) G16B 40/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279386 | CHEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Encodia, Inc. (San Diego, California) |
| ASSIGNEE(S) | Encodia, Inc. (San Diego, California) |
| INVENTOR(S) | Mark S. CHEE (Encinitas, California); Kevin L. Gunderson (Encinitas, California); Norihito Muranaka (San Diego, California); Brian Tate Weinert (San Diego, California) |
| ABSTRACT | Provided herein are methods for preparing and treating an analyte (e.g., a macromolecule or a plurality of macromolecules, peptides, polypeptides, and proteins) for analysis. In some embodiments, the analyte is prepared and treated in a method that includes the use of bait and capture nucleic acids, solid supports, and reaction mixtures including the bait and capture nucleic acids. In some embodiments, the analyte is coupled to a solid support. Also provided are kits containing components for performing the provided methods for preparing the analytes. In some embodiments, the methods are for preparing an analyte for sequencing. |
| FILED | Friday, March 24, 2023 |
| APPL NO | 18/190001 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279387 | Zhuang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Xiaowei Zhuang (Cambridge, Massachusetts); Kok-Hao Chen (Cambridge, Massachusetts); Alistair Boettiger (Cambridge, Massachusetts); Jeffrey R. Moffitt (Cambridge, Massachusetts); Siyuan Wang (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches. |
| FILED | Friday, April 07, 2023 |
| APPL NO | 18/297378 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) C07H 21/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/1065 (20130101) Original (OR) Class C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6837 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 25/20 (20190201) G16B 30/00 (20190201) G16B 40/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279393 | WOODRUFF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | PRESCOTT WOODRUFF (San Francisco, California); KRISTINA JOHANSSON (San Francisco, California); SANA SIDDIQUI (San Francisco, California) |
| ABSTRACT | The inventions provide the art with novel treatments of various airway conditions such as asthma wherein pathological production of mucus is implicated. Disclosed are novel inhibitors of miR-200 micro-RNAs, including inhibitors of miR-141. These miRNAs promote pathological mucus production and other airway dysfunction. They may be targeted by antagomirs which disrupt their activity. Additionally, they may be targeted by compositions with disrupt the gene expression of the targeted miR. |
| FILED | Wednesday, October 14, 2020 |
| APPL NO | 17/769322 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279434 | MacLennan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Alexander John MacLennan (Cincinnati, Ohio) |
| ABSTRACT | A method for slowing the progression of amyotrophic lateral sclerosis (ALS) in an adult subject in need thereof is provided herein, the method including inhibiting motor neuron degeneration by administering to the subject a modified adeno-associated virus (AAV) vector having a recombinant AAV (rAAV)-based genome with an AAV backbone, a control element, and a ciliary neurotrophic factor receptor alpha (CNTFRα) cDNA insert, wherein the modified AAV vector is engineered to direct enhanced skeletal muscle expression of CNTFRα. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/069650 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/52 (20130101) C07K 14/71 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279443 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Kevin Davis (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity of RNA-programmable endonucleases, such as Cas9, or for controlling the activity of proteins comprising a Cas9 variant fused to a functional effector domain, such as a nuclease, nickase, recombinase, deaminase, transcriptional activator, transcriptional repressor, or epigenetic modifying domain. For example, the inventive proteins provided comprise a ligand-dependent intein, the presence of which inhibits one or more activities of the protein (e.g., gRNA binding, enzymatic activity, target DNA binding). The binding of a ligand to the intein results in self-excision of the intein, restoring the activity of the protein. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/069898 |
| CURRENT CPC | Peptides C07K 14/35 (20130101) C07K 14/721 (20130101) C07K 2319/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/0071 (20130101) C12N 9/78 (20130101) C12N 15/63 (20130101) C12N 15/907 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Enzymes C12Y 114/11 (20130101) C12Y 305/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279450 | Buller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Buller (Madison, Wisconsin); Tyler Doyon (Eau Claire, Wisconsin) |
| ABSTRACT | A method for site-selective deuteration of amino acids using a protein system having an aminotransferase (e.g., DsaD) and/or a small partner protein (e.g., DsaE). A non-deuterated amino acid is contacted with deuterium and an aminotransferase or a combination of an aminotransferase and a partner protein, to yield a Cα-deuterated or a Cα- and Cβ-deuterated amino acid. Cβ-deuterated amino acids can be accessed by contacting a Cα- and Cβ-deuterated amino acid with non-deuterium hydrogen and an aminotransferase to wash out the deuterium at the Ca carbon atom by the non-deuterium hydrogen. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/179946 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 227/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/005 (20130101) Original (OR) Class Enzymes C12Y 404/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279470 | Van Nostrand et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Van Nostrand (La Jolla, California); Eugene Yeo (La Jolla, California); Alexander Shishkin (La Jolla, California) |
| ABSTRACT | Described herein are efficient methods for preparing a library for use in comprising performing gene targeting or massively parallel reporter assays. The methods comprise performing hybrid capture of a library constant region. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169681 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279484 | Daugharthy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan R. Daugharthy (Cambridge, Massachusetts); Richard C. Terry (Carlisle, Massachusetts); Je-Hyuk Lee (Allston, Massachusetts); George M. Church (Brookline, Massachusetts); Benjamin W. Pruitt (Cambridge, Massachusetts) |
| ABSTRACT | Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix of nucleic acids is provided. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/956892 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6841 (20130101) C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279495 | Higginson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (NEW YORK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Smith Higginson (New York, New York); Jonathan E. Leeman (Weymouth, Massachusetts) |
| ABSTRACT | The present invention relates to molecular signatures in genomic DNA that are associated with sensitivity of tumors, such as HPV-associated tumors, to treatment with radiation therapy. The present invention provides methods of analyzing tissue samples, or DNA obtained therefrom, to assess the presence of such molecular signatures, methods of predicting whether a tumor in a subject will be sensitive to treatment with radiation therapy based on the presence of such signatures, and methods of treating subjects with radiation therapy if such signatures are present. |
| FILED | Wednesday, October 07, 2020 |
| APPL NO | 17/767027 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279505 | Ostrander et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Elaine Ostrander (Potomac, Maryland); Leonid Kruglyak (Princeton, New Jersey); Heidi G. Parker (Germantown, Maryland); Lisa V. Kim (Seattle, Washington); Matthew Stephens (Seattle, Washington); Tiffany B. Malek (La Mesa, California); Nathan B. Sutter (Rockville, Maryland); Scott Carlson (Seattle, Washington) |
| ABSTRACT | In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063532 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6888 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 20/40 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280261 | GRISHAM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GPB Scientific, Inc. (Richmond, Virginia); University of Maryland, Baltimore (Baltimore, Maryland); Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael GRISHAM (Richmond, Virginia); Curt I. CIVIN (Baltimore, Maryland); James C. STURM (Princeton, New Jersey); Robert H. AUSTIN (Princeton, New Jersey); Joseph D'SILVA (Princeton, New Jersey); Yu CHEN (Princeton, New Jersey) |
| ABSTRACT | Described herein are microfluidic devices and methods that can greatly improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/952701 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 3/502776 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1484 (20130101) Original (OR) Class G01N 30/6069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280291 | Yun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sigray, Inc. (Concord, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenbing Yun (Walnut Creek, California); Benjamin Donald Stripe (Walnut Creek, California); Frances Yenan Su (Walnut Creek, California); Vikaram Singh (Concord, California); Sylvia Jia Yun Lewis (San Francisco, California); Janos Kirz (Berkeley, California) |
| ABSTRACT | A system includes a stage for supporting a sample having at least first and second atomic elements. The first atomic element has a first characteristic x-ray line with a first energy and the second atomic element has a second characteristic x-ray line with a second energy, the first and second energies lower than 8 keV and separated from one another by less than 1 keV. The system further includes an x-ray source of x-rays having a third energy between the first and second energies and at least one x-ray optic configured to receive and focus at least some of the x-rays as an x-ray beam to illuminate the sample. The system further includes at least one x-ray detector configured to detect fluorescence x-rays produced by the sample in response to being irradiated by the x-ray beam. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/175171 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/223 (20130101) Original (OR) Class G01N 23/2204 (20130101) G01N 2223/204 (20130101) G01N 2223/206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280334 | Ching et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mary Jane Tsang Mui Ching (Melbourne, Australia); Iain Cheeseman (Brookline, Massachusetts) |
| ABSTRACT | Disclosed are methods of screening for agents to treat cancers resistant to anti-mitotic therapy, methods of detecting cancers resistant to anti-mitotic therapy, and methods of treating cancers resistant to anti-mitotic therapy. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878774 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280339 | Qin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Avsana Labs Incorporated (Richardson, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenpeng Qin (Austin, Texas); Dennis I. Robbins (Richardson, Texas); Nadine va Zyl (Richardson, Texas); Haihang Ye (Austin, Texas); Peiyuan Kang (Austin, Texas) |
| ABSTRACT | A biochemical assay device including a detection channel, a light source and a hydrophone. The detection channel fluidly coupleable to a specimen source to receive an analyte sample that can include a biological target bound to a bioreceptor gold nanoparticle conjugate. The light source situated to send a light to the detection channel, where the light includes one or more wavelengths absorbable by the bioreceptor gold nanoparticle conjugate bound to the biological target to thereby generate a photoacoustic signal indicative of an individual acoustic detection event from the bioreceptor gold nanoparticle conjugates to the biological target in the analyte sample. The hydrophone to detect and convert a summation of the photoacoustic digital signals into an electrical signal. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/176056 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/16 (20130101) B01L 2200/0652 (20130101) B01L 2300/0636 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54346 (20130101) G01N 33/54373 (20130101) Original (OR) Class G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280344 | Medin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. Medin (Shorewood, Wisconsin); Robyn A. Oldham (Milwaukee, Wisconsin); Mary L. Faber (Milwaukee, Wisconsin); Rebekah L. Gundry (Milwaukee, Wisconsin) |
| ABSTRACT | The present invention provides methods and kits for detecting and treating multiple myeloma. The methods involve detecting proteins that the inventors have identified as biomarkers of multiple melanoma. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 18/005802 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) Original (OR) Class G01N 2333/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280577 | Valdes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pablo A. Valdes (Hanover, New Hampshire); David W. Roberts (Lyme, New Hampshire); Keith D. Paulsen (Hanover, New Hampshire); Frederic Leblond (Montreal, Canada) |
| ABSTRACT | An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target. |
| FILED | Monday, May 08, 2023 |
| APPL NO | 18/144767 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/063 (20130101) Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) Original (OR) Class G02B 21/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281751 | Yan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pingkun Yan (Clifton Park, New York); Hengtao Guo (Troy, New York); Xinrui Song (Troy, New York); Xuanang Xu (Troy, New York) |
| ABSTRACT | A method of multi-modal image registration is provided. The method includes receiving as input a fixed image from a first imaging device, receiving as input a moving image from a second imaging device, performing feature extraction on the fixed image via a first feature extractor to generate a fixed image feature map, performing feature extraction on the moving image via second feature extractor to generate a moving image feature map, performing cross-modal attention on the fixed image feature map and the moving image feature map to generate cross-modal feature attention data, performing deep registration on the cross-modal feature attention data via a deep registrator, and outputting a multi-modal registered image. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/092531 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/0068 (20130101) Original (OR) Class G06T 7/337 (20170101) G06T 2207/10088 (20130101) G06T 2207/10132 (20130101) G06T 2207/20084 (20130101) G06T 2207/20221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281762 | Nasrabadi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Mogantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nasser M. Nasrabadi (Morgantown, West Virginia); Jeremy M. Dawson (Fairmont, West Virginia); Amol Joshi (Morgantown, West Virginia); Ali Dabouei (Morgantown, West Virginia) |
| ABSTRACT | Various examples are provided related to fingerphoto deblurring. In one example, a method includes generating, using a guided-attention (GA) mechanism, an intermediate feature map of a blurred image of a fingerprint and generating a deblurred image of the fingerprint based at least in part upon the intermediate feature map. The GA mechanism can generate the intermediate feature map by generating an attended feature map from an input feature map based upon a predicted attention map and adding the input feature map to the attended feature map. A system can include processing circuitry and a fingerphoto deblurring application that, when executed by the processing circuitry, causes the processing circuitry to generate the intermediate feature map and generate the deblurred image. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/112701 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4046 (20130101) G06T 5/003 (20130101) Original (OR) Class G06T 2207/20016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281805 | Haghighi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatemeh Haghighi (Tempe, Arizona); Mohammad Reza Hosseinzadeh Taher (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | A Discriminative, Restorative, and Adversarial (DiRA) learning framework for self-supervised medical image analysis is described. For instance, a pre-trained DiRA framework may be applied to diagnosis and detection of new medical images which form no part of the training data. The exemplary DiRA framework includes means for receiving training data having medical images therein and applying discriminative learning, restorative learning, and adversarial learning via the DiRA framework by cropping patches from the medical images; inputting the cropped patches to the discriminative and restorative learning branches to generate discriminative latent features and synthesized images from each; and applying adversarial learning by executing an adversarial discriminator to perform a min-max function for distinguishing the synthesized restorative image from real medical images. The pre-trained model of the DiRA framework is then provided as output for use in generating predictions of disease within medical images. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/111136 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/20132 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/761 (20220101) G06V 10/762 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281825 | JOHNSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ALLEN INSTITUTE (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory JOHNSON (Seattle, Washington); Chawin OUNKOMOL (Seattle, Washington); Forrest COLLMAN (Seattle, Washington); Sharmishtaa SESHAMANI (Seattle, Washington) |
| ABSTRACT | A computing device, method, system, and instructions in a non-transitory computer-readable medium for performing image analysis on 3D microscopy images to predict localization and/or labeling of various structures or objects of interest, by predicting the location in such images at which a dye or other marker associated with such structures would appear. The computing device, method, and system receives sets of 3D images that include unlabeled images, such as transmitted light images or electron microscope images, and labeled images, such as images captured with fluorescence tagging. The computing device trains a statistical model to associate structures in the labeled images with the same structures in the unlabeled light images. The processor further applies the statistical model to a new unlabeled image to generate a predictive labeled image that predicts the location of a structure of interest in the new image. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/170076 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/008 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/045 (20230101) G06N 20/20 (20190101) Image Data Processing or Generation, in General G06T 7/11 (20170101) Original (OR) Class G06T 7/174 (20170101) G06T 7/187 (20170101) G06T 2207/10061 (20130101) G06T 2207/10064 (20130101) G06T 2207/30024 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/50 (20220101) G06V 10/764 (20220101) G06V 20/695 (20220101) G06V 20/698 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281970 | DORETTO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gianfranco DORETTO (Morgantown, West Virginia); Matthew Richardson KEATON (Morgantown, West Virginia) |
| ABSTRACT | System and methods for object segmentation include providing a pre-trained neural network model to segment object instances based on a first set of images and a first loss function. The neural network, for a pixel, can generate a gradient flow that points towards a center of an object structure and provides a probability score indicating a probability of the pixel belonging to the object structure. An adapted neural network model can be generated from the pre-trained neural network model to account for domain shifted new input images by training the pre-trained neural network model on a second set of images and a loss function that comprises a contrastive flow loss component and a contrastive mask loss component. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/118566 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30004 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/761 (20220101) G06V 10/774 (20220101) Original (OR) Class G06V 20/695 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282311 | Behsaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bahar Behsaz (Pasadena, California); Liu Cao (Pittsburgh, Pennsylvania); Mustafa Guler (Pittsburgh, Pennsylvania); Yi-Yuan Lee (Ithaca, New York); Hosein Mohimani (Pittsburgh, Pennsylvania); Mihir Mongia (Pittsburg, Pennsylvania); Donghui Yan (Pittburgh, Pennsylvania) |
| ABSTRACT | A method and system is for receiving data representing gene clusters, the gene clusters including one or more genes configured to encode one or more polypeptides or other small molecules; accessing a machine learning model, the machine learning model being trained with a training dataset that associates the gene clusters to structures of one or more small molecules represented in the data; applying the machine learning model to the data representing the gene clusters; identifying, based on applying the machine learning model, one or more monomers associated with at least one gene cluster represented in the data; and determining a structure for a natural product including the one or more monomers. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/076280 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282470 | COON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Jacques COON (Middleton, Wisconsin); Michael Scott WESTPHALL (Fitchburg, Wisconsin) |
| ABSTRACT | Systems and methods for controllably forming an analyte layer comprising amorphous ice and/or other frozen amorphous solids on a substrate. In an embodiment, the present invention provides simplified systems and methods for the preparation of cryo-EM samples, where the same particle beam, such as an ion beam, is used to deposit the desired analyte onto the substrate as well as to generate the amorphous ice or frozen solid layer on the substrate |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178205 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/24 (20130101) H01J 49/0031 (20130101) H01J 49/164 (20130101) H01J 49/165 (20130101) Original (OR) Class H01J 49/0445 (20130101) H01J 49/0468 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230276788 | Wei |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | X-THERMA, INC. (Richmond, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoxi Wei (El Cerrito, California) |
| ABSTRACT | The present invention provides peptoid polymers capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids comprising the peptoid polymers provided herein. The peptoid polymers and peptoid-peptide hybrids provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 17/974202 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class Preserving, e.g by Canning, Meat, Fish, Eggs, Fruit, Vegetables, Edible Seeds; Chemical Ripening of Fruit or Vegetables; the Preserved, Ripened, or Canned Products A23B 4/20 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/32 (20130101) A23G 9/38 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 3/37 (20130101) A23L 3/3526 (20130101) A23L 13/42 (20160801) A23L 17/00 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 8/64 (20130101) A61K 8/88 (20130101) A61K 2800/54 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 90/00 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/001 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/10 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 3/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230276877 | Jin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael H. Jin (Ellicott City, Maryland); Evan D. Jacque (Columbia, Maryland); Jarod C. Gagnon (Finksburg, Maryland); Nathan J. Fairbanks (Montgomery Village, Maryland); Drew P. Seker (Ellicott City, Maryland); Kenneth Bontje (Vancouver, Canada); Mark Bollong (Oceanside, California) |
| ABSTRACT | A diving glove includes quilted material defining a plurality of pockets. Each of the pockets is filled with aerogel beads. The glove may be worn underneath a waterproof layer in a dry diving suit. The glove includes multiple seams dividing the pockets. The seams are located to maintain a distribution of beads across the glove that effectively insulates the wearer's hand and prevents the beads from impeding the wearer's manual dexterity. The glove includes a web portion extending across a back side of the fingers. The web portion can be used to create an enclosed space for insulating the wearer's fingers. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/091499 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/012 (20130101) A41D 19/0006 (20130101) A41D 19/01529 (20130101) Original (OR) Class A41D 31/065 (20190201) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 2307/7265 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277057 | Maharbiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michel M. Maharbiz (El Cerrito, California); Jose M. Carmena (Berkeley, California); Dongjin Seo (Albany, California); Monica Lin (San Francisco, California); Meir Marmor (Oakland, California); Safa Herfat (Oakland, California); Chelsea Shields Bahney (Oakland, California) |
| ABSTRACT | Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/111499 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0031 (20130101) Original (OR) Class A61B 5/076 (20130101) A61B 5/279 (20210101) A61B 5/686 (20130101) A61B 6/4258 (20130101) A61B 8/48 (20130101) A61B 8/085 (20130101) A61B 8/0808 (20130101) A61B 8/0875 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 39/0208 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3605 (20130101) A61N 1/3787 (20130101) A61N 1/37205 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277120 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Wilson (Irvine, California); Wei Jin (Irvine, California); Rebecca Rowland (San Anselmo, California); Gordon Kennedy (Irvine, California); Anthony Durkin (Irvine, California); Sahil Ahuja (Irvine, California) |
| ABSTRACT | The disclosure provides methods for accurately quantifying optical properties of skin in subjects that have varying skin tones, and applications thereof. |
| FILED | Saturday, March 04, 2023 |
| APPL NO | 18/117422 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/443 (20130101) Original (OR) Class A61B 5/445 (20130101) A61B 5/7221 (20130101) A61B 5/7246 (20130101) A61B 5/14551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277341 | Sanders et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joan E. Sanders (Seatlle, Washington); Joseph L. Garbini (Seattle, Washington); Clement Gurrey (Seattle, Washington); Katheryn J. Allyn (Seattle, Washington); Jake McLean (Seattle, Washington); Brian Larsen (Seattle, Washington) |
| ABSTRACT | The present disclosure provides a device configured to be positioned within a prosthetic socket. The device includes a tether having a first end and a second end opposite the first end. The first end of the tether is configured to be coupled to a prosthetic liner. The device also includes a spool fixed with respect to the prosthetic socket. The second end of the tether is coupled to the spool. The device also includes a motor and a battery configured to provide power to the motor. The device also includes a coupling mechanism configured to transition from a first position in which the spool is only able to rotate in a first direction to a second position in which the spool is able to rotate in the first direction and a second direction. The device also includes a release actuator positioned on an exterior of the prosthetic socket. Actuation of the release actuator causes the coupling mechanism to transition from the first position to the second position. The device also includes a tightening actuator positioned on the exterior of the prosthetic socket. Actuation of the tightening actuator causes the motor to rotate the spool in the first direction to wind the tether around the spool to thereby reduce a distance between the first end of the tether and the spool. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178138 |
| CURRENT CPC | Fastenings or Attachments of Footwear; Laces in General A43C 11/165 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/80 (20130101) Original (OR) Class A61F 2002/802 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277355 | Loke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRITON SYSTEMS, INC. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marmaduke J. Loke (Lowell, Massachusetts); Marya H. Schnedeker (Cambridge, Massachusetts); Michael J. Guarino (Wakefield, Massachusetts); William M. Lindsey (Lowell, Massachusetts); James F. Saunders (Lowell, Massachusetts); George Santiago (Marlborough, Massachusetts); Brian E. Moyer (Nashua, New Hampshire) |
| ABSTRACT | Disclosed is a splint system for protecting and immobilizing an injured body segment and/or associated joint. The splint system is a garment-based splint system including a garment including an inner fabric layer having a skin-facing surface layer and an interior surface layer, and an outer fabric layer, wherein the inner fabric layer and the outer fabric layer define one or more pockets and one or more channels connecting a filler source to the one or more pockets. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176938 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/0012 (20130101) A41D 13/1236 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277356 | Loke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRITON SYSTEMS, INC. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marmaduke J. Loke (Lowell, Massachusetts); Marya H. Schnedeker (Cambridge, Massachusetts); Michael J. Guarino (Wakefield, Massachusetts); William M. Lindsey (Lowell, Massachusetts); James F. Saunders (Lowell, Massachusetts); George Santiago (Marlborough, Massachusetts); Brian E. Moyer (Nashua, New Hampshire) |
| ABSTRACT | Disclosed is an orthosis device particularly well-suited for use in the field. The orthosis system includes a tibial cuff, at least one strut, an optional off-loading cuff, and a foot plate. The struts connect the tibial cuff to the footplate. Optional couplers may be used to facilitate these connections and may be in the form of quick disconnects or cam locks. The footplate may further spring plate having energy return properties to aid mobility. The systems may be modular, is compact, and easily stowed and carried. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176966 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/0585 (20130101) Original (OR) Class A61F 5/05825 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277569 | Altieri |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE WISTAR INSTITUTE (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dario C. Altieri (Philadelphia, Pennsylvania) |
| ABSTRACT | Described herein is a method of treating, ameliorating and/or preventing cancer in a subject in need thereof. The method includes administering to the subject therapeutically effective amounts of Gamitrinib according to one of certain specific administration schemes (protocols). Also described herein is a kit for performing the methods of the disclosure. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/115945 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) Original (OR) Class A61K 47/20 (20130101) A61K 47/24 (20130101) A61K 47/26 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277570 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingyin Li (Stanford, California); Mark Smith (Stanford, California); Kelsey Erin Shaw (Stanford, California); Jacqueline Ann Carozza (Stanford, California); Volker Boehnert (Stanford, California) |
| ABSTRACT | Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a ENPP1 inhibitor to inhibit cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor is cell impermeable. Also provided are compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of a ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject either before or after administering an ENPP1 inhibitor. The radiation therapy can be administered at a dosage and/or frequency effective to reduce radiation damage to the subject. In certain cases, the method is performed in combination with a chemotherapeutic agent, or a checkpoint inhibitor, or both. |
| FILED | Tuesday, May 16, 2023 |
| APPL NO | 18/197877 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277623 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong Feng Chen (Newtonville, Massachusetts); Chenying Guo (Malden, Massachusetts) |
| ABSTRACT | Disclosed is a method of promoting neuronal growth by administering IGFBPL-1, or an agent that increases or stabilizes IGFBPL-1 activity to a subject in need thereof, e.g., a subject in need of treating optic nerve degeneration. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/073951 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/352 (20130101) A61K 31/708 (20130101) A61K 31/711 (20130101) A61K 31/713 (20130101) A61K 31/7004 (20130101) A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 38/18 (20130101) Original (OR) Class A61K 38/22 (20130101) A61K 38/30 (20130101) A61K 38/1738 (20130101) A61K 38/1841 (20130101) A61K 38/2278 (20130101) A61K 45/06 (20130101) A61K 49/0056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277683 | Shukla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anita Shukla (East Greenwich, Rhode Island); Yingying Wang (Providence, Rhode Island) |
| ABSTRACT | A method of making and using nanoparticles that target bacterial biofilm are provided. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/175610 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/65 (20130101) A61K 47/6939 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277695 | LAKSHMANAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anupama LAKSHMANAN (Pasadena, California); Arash FARHADI (Pasadena, California); Suchita P. NETY (Sunnyvale, California); Raymond W. BOURDEAU (Watertown, Massachusetts); Mikhail SHAPIRO (Los Angeles, California) |
| ABSTRACT | Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046881 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/481 (20130101) A61B 8/5238 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 49/0045 (20130101) A61K 49/0093 (20130101) A61K 49/221 (20130101) A61K 49/223 (20130101) Original (OR) Class Peptides C07K 14/195 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277831 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Hong CHEN (St. Louis, Missouri); Zhongtao HU (St. Louis, Missouri); Si CHEN (St. Louis, Missouri); Yaoheng YANG (St. Louis, Missouri); Yan GONG (St. Louis, Missouri) |
| ABSTRACT | Devices, systems, and methods for performing focused ultrasound-mediated blood-brain barrier opening (FUS-BBBO) are disclosed. Focused ultrasound (FUS) devices are disclosed that include an adapter configured to attach to an actuated mounting shaft of a stereotaxic system, a transducer housing configured to mount to the adapter, and a FUS transducer housed within the transducer housing. A FUS system is disclosed that includes the disclosed FUS device operatively coupled to a transducer driving system. A stereotaxic-guided FUS-BBB system is disclosed that includes the disclosed FUS system mounted to an actuated mounting shaft of a stereotaxic system. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/179966 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0092 (20130101) Original (OR) Class A61M 2209/088 (20130101) A61M 2210/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278695 | Rathay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas William Rathay (Rock City Falls, New York); Gregory Alexander Natsui (Schenectady, New York); Thomas Earl Dyson (Niskayuna, New York) |
| ABSTRACT | A leading edge assembly for a hypersonic vehicle is provided. The leading edge assembly includes an outer wall that tapers to a leading edge, the outer wall having a porous region at the leading edge; a coolant supply assembly in fluid communication with the porous region for selectively providing a flow of coolant through the porous region of the outer wall; and an insulation layer disposed between a portion of the coolant supply assembly and the outer wall, wherein the insulation layer is configured to reduce heat transfer between the coolant supply assembly and the outer wall. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688085 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 1/38 (20130101) Original (OR) Class B64C 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278896 | Walton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Scott G. Walton (Fairfax, Virginia); William A. Maza (Silver Spring, Maryland); Michael J. Johnson (Annapolis, Maryland); David R. Boris (Annandale, Virginia); Vanessa M. Breslin (Branford, Connecticut); Grant C. Daniels (Burke, Virginia); Robert B. Balow (Mount Ranier, Maryland) |
| ABSTRACT | Apparatus and method for decontaminating both contaminated waters and sorbent filter media, either separately or simultaneously, in a single system. Contaminants in a liquid flowing through a reaction chamber are removed by first generating a plasma within the liquid in the chamber, with the contaminants being broken into smaller particles at the interfaces between the generated plasma and the liquid. The combined plasma-liquid solution is then passed through a solid filter, which captures the smaller contaminant particles to decontaminate the liquid. To decontaminate the filter media, plasma flows through the filter material without the presence of liquid, the plasma reacting with the filter material to remove contaminants previously adsorbed by the filter. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/177850 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/001 (20130101) C02F 1/4608 (20130101) Original (OR) Class C02F 2101/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278942 | Palmese et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DREXEL UNIVERSITY (PHILADELPHIA, Pennsylvania); The Government of the United States of America, as represented by The Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania); The Government of the United States of America, as represented by The Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Giuseppe R. Palmese (Hainesport, New Jersey); Emre Kinaci (Philadelphia, Pennsylvania); John J. LaScala (Wilmington, Delaware) |
| ABSTRACT | A polymerizable monomer prepared by reacting at least one epoxidized cardanol with (meth)acrylic anhydride or (meth)acryloyl chloride in the presence of one or more of triethylamine, tertiary amines, pyridines and pyridine derivatives; wherein the epoxidized cardanol is formed by epoxidation of an unsaturation site of a cardanol having the formula: wherein R is selected from hydrogen and an alkyl, or alkenyl group having 1-6 carbon atoms, and n is 7, 10, or 13, a polymer and resin made form the polymerizable monomer, and a method of preparing such a polymer. The resin created from this monomer is suitable for moderate temperature composites and coatings applications. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 18/053589 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 39/19 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 222/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279054 | MULLIGAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vikram K. MULLIGAN (Seattle, Washington); Christine KANG (Seattle, Washington); Timothy CRAVEN (Seattle, Washington); David BAKER (Seattle, Washington) |
| ABSTRACT | The disclosure provides polypeptide comprising or consisting of an amino acid sequence at least 66%, 70%, 75%, 80%, 82%, 84%, 86%, 88%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NO: 1-91 as shown in Table I, wherein: (a) amino acid residues in upper case are L amino acids, and residues in lower case are D amino acids; (b) X is 2-aminoisobutyric acid (ATB); (c) no amino acid changes at proline or AIB e residues in the reference peptide are permitted; and (d) any amino acid changes must maintain chirality relative to the reference peptide. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 18/040746 |
| CURRENT CPC | Peptides C07K 7/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279055 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); El Consejo Superior de Investigaciones Científicas (Madrid, Spain) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Baker (Seattle, Washington); Tamuka Chidyausiku (Seattle, Washington); Jason C. Klima (Seattle, Washington); Enrique Marcos Benteo (Seattle, Washington); F. Xavier Gomis Rüth (Madrid, Spain); Soraia Dos Reis Mendes (Madrid, Spain); Ulrich Eckhard (Madrid, Spain); Marta Nadal Rovira (Madrid, Spain); Jorge Luis Roel Touris (Madrid, None) |
| ABSTRACT | The disclosure provides antibody-like polypeptides of the formula X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15, wherein the domains are as defined herein, nucleic acids encoding the polypeptides, and methods for use and design of the polypeptides. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177367 |
| CURRENT CPC | Peptides C07K 14/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279056 | QUIJANO RUBIO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfredo QUIJANO RUBIO (Seattle, Washington); Jooyoung PARK (Seattle, Washington); Hsien-Wei YEH (Seattle, Washington); David BAKER (Seattle, Washington); Longxing CAO (Seattle, Washington); Brian COVENTRY (Seattle, Washington); Inna GORESHNIK (Seattle, Washington); Lisa KOZODOY (Seattle, Washington); Lance Joseph STEWART (Seattle, Washington) |
| ABSTRACT | The disclosure provides cage proteins comprising a helical bundle, wherein the cage protein comprises a structural region and a latch region, wherein the latch region comprises one or more target binding polypeptide, wherein the cage protein further comprises a first reporter protein domain, wherein the first reporter protein domain undergoes a detectable change in reporting activity when bound to a second split reporter protein domain, and wherein the structural region interacts with the latch region to prevent solution access to the one or more target binding polypeptide. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/999524 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279084 | Marks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. Marks (Kensington, California); Maria Consuelo Garcia Rodriguez (San Francisco, California); Jianbo Dong (San Francisco, California); Zhengda Sun (San Francisco, California) |
| ABSTRACT | The present disclosure provides antibodies that specifically bind to botulinum neurotoxins. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used in methods to specifically bind and, in some embodiments, neutralize, botulinum neurotoxin and are therefore also useful in the treatment. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046751 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/1282 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/549 (20130101) G01N 33/563 (20130101) G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279443 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Kevin Davis (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity of RNA-programmable endonucleases, such as Cas9, or for controlling the activity of proteins comprising a Cas9 variant fused to a functional effector domain, such as a nuclease, nickase, recombinase, deaminase, transcriptional activator, transcriptional repressor, or epigenetic modifying domain. For example, the inventive proteins provided comprise a ligand-dependent intein, the presence of which inhibits one or more activities of the protein (e.g., gRNA binding, enzymatic activity, target DNA binding). The binding of a ligand to the intein results in self-excision of the intein, restoring the activity of the protein. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/069898 |
| CURRENT CPC | Peptides C07K 14/35 (20130101) C07K 14/721 (20130101) C07K 2319/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/0071 (20130101) C12N 9/78 (20130101) C12N 15/63 (20130101) C12N 15/907 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Enzymes C12Y 114/11 (20130101) C12Y 305/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279525 | PITTARI, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John J. PITTARI, III (Nottingham, Maryland); Steven M. Kilczewski (Belcamp, Maryland); Jeffrey J. Swab (Fallston, Maryland); Kristopher A. Darling (Havre De Grace, Maryland); Billy C. Hornbuckle (Aberdeen, Maryland); Heather A. Murdoch (Baltimore, Maryland); Robert J. Dowding (Abingdon, Maryland) |
| ABSTRACT | A sintered cemented carbide body including tungsten carbide, and a substantially cobalt-free binder including an iron-based alloy sintered with the tungsten carbide. The iron-based alloy is approximately 2-25% of the overall weight percentage of the sintered tungsten carbide and iron-based alloy. The tungsten carbide may be approximately 90 wt % and the iron-based alloy may be approximately 10 wt % of the overall weight percentage of the sintered tungsten carbide and iron-based alloy. The tungsten carbide may comprise a substantially same size before and after undergoing sintering. The iron-based alloy may be sintered with the tungsten carbide using a uniaxial hot pressing process, a spark plasma sintering process, or a pressureless sintering process. The sintered tungsten carbide and iron-based alloy has a hardness value of at least 15 GPa and a fracture toughness value of at least 11 MPa√m. |
| FILED | Friday, August 12, 2022 |
| APPL NO | 17/886949 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/14 (20130101) B22F 3/105 (20130101) Alloys C22C 1/051 (20130101) C22C 29/02 (20130101) Original (OR) Class C22C 29/08 (20130101) C22C 29/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279565 | LUCKENBAUGH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army DEVCOM Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | THOMAS L. LUCKENBAUGH (Spring Grove, Pennsylvania); Anthony J. Roberts (Chesapeake City, Maryland); Billy C. Hornbuckle (Bel Air, Maryland); Anit K. Giri (Abingdon, Maryland); Kristopher A. Darling (Havre de Grace, Maryland) |
| ABSTRACT | A dissolvable engineered component fabricated using an aluminum-based nanogalvanic alloy and a method of manufacturing such a dissolvable engineered component. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/684540 |
| CURRENT CPC | Alloys C22C 21/00 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 11/037 (20210101) Original (OR) Class C25B 11/046 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279916 | Baur et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffery Baur (Liberty Township, Ohio); David Seifert (Beavercreek, Ohio); Geoffrey Frank (Dayton, Ohio); Patrick Walgren (Anchorage, Alaska); Darren Hartl (College Station, Ohio); Wesley Chapkin (Fairborn, Ohio) |
| ABSTRACT | A flexible multi-material structure comprises a plurality of overlapping rings that form a generally circular shape perpendicular to a longitudinal axis of the structure; an internal compliant hollow frame having a circumference corresponding to the generally circular shape of the plurality of rings, the internal frame comprising: a plurality of connection clips wherein each connection clip is attached one of the plurality of rings, the internal frame and connection clips defining a longitudinal spacing between the plurality of rings, each of the plurality of rings is shaped to minimize contact with adjacent rings when the structure is articulated, each ring including a spherical profile along an aft interior region which nests with a forward outer region of an adjacent ring, wherein connections between the rings and the frame allows independent motion of the rings and frame, allowing each ring to pivot about a geometric center of the spherical profile. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/929763 |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 3/02 (20130101) Original (OR) Class F16F 2236/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280138 | Gleaton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Daniel A. Gleaton (Bloomington, Indiana); Michael L. Holzmeyer (Bloomfield, Indiana); Paul C. Denesha, Jr. (Bedford, Indiana); Max Melbourne Irwin (Bloomington, Indiana); Joshua F. Harding (Vincennes, Indiana); Eric Scott Gilham (Otwell, Indiana); Steven L. Backer (Jasper, Indiana) |
| ABSTRACT | Provided is an ammunition container lid for use with an ammunition canister. The container lid includes a four-sided frame, a cover, a hinge assembly, a feed tray, a latch, and a Last Round Switch. The hinge assembly includes a repeating pattern of ammunition can hinge sections, feed tray hinge sections, and cover hinge sections with a rod holding the sections together. The lid has an integrated aerodynamic forward face that matches the curvature of the ammunition can. The feed tray assembly is incorporated into the container lid to prevent a reduction in ammunition can capacity. The cover and feed tray rotate on the same axis, thereby resulting in simplified, ergonomic operation, which eliminates the problems inherent in current designs that can open directly into the airstream during flight. The inventive lid does not require special tools for installation/removal and does not reduce ammunition can capacity. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/117726 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 39/002 (20130101) F42B 39/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280259 | Jalali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bahram Jalali (Los Angeles, California); Eric D. Diebold (Los Angeles, California); Brandon Buckley (Los Angeles, California) |
| ABSTRACT | An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/117708 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) Original (OR) Class G01N 15/1459 (20130101) G01N 15/1484 (20130101) G01N 21/64 (20130101) G01N 33/537 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280343 | Montclare et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin Kim Montclare (New York, New York); Farbod Mahmoudinobar (Harrison, New Jersey); Kamia Punia (Staten Island, New York); Dustin Robert Britton (Brooklyn, New York) |
| ABSTRACT | Provided is a multivalent protein that targets interaction of SARS-CoV-2 spike receptor binding domain (RBD) with the human angiotensin-converting enzyme 2 (ACE2) receptor protein. The multivalent proteins may also be used to treat subjects having cancer and/or a disease and/or viral infection. Also presented is a multiplex lateral flow test strips for simultaneous detection of the virus and viral antibodies. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 18/058703 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/78 (20130101) C07K 2319/50 (20130101) Enzymes C12Y 304/17023 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54388 (20210801) G01N 33/56983 (20130101) Original (OR) Class G01N 2469/10 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280349 | Al-Hendy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); Inova Health System (Falls Church, Virginia); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois); Inova Health System (Falls Church, Virginia); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| INVENTOR(S) | Ayman Al-Hendy (Hinsdale, Illinois); Hiba Alkelani (Chicago, Illinois); Thomas Patrick Conrads (Reston, Virginia); George Larry Maxwell (Washington, District of Columbia); Nicholas William Bateman (Leesburg, Virginia); Waleed Barakat (Reston, Virginia) |
| ABSTRACT | In aspects, the disclosure provides a method of differentiating a malignant tumor from a non-malignant tumor in a mammal having a tumor comprising determining in a sample from the mammal the level of one or more of: (1) transthyretin (TTR) RNA or protein, (2) dual oxidase 2 (DUOX2) RNA or protein, and (3) G-protein coupled receptor 179 (GPR179) RNA or protein. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176909 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57488 (20130101) Original (OR) Class G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281319 | DeHon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andre Maurice DeHon (Philadelphia, Pennsylvania); Nicholas Edward Roessler (Philadelphia, Pennsylvania) |
| ABSTRACT | Methods, systems, and computer readable media for generating compartmentalization security policies and/or methods, systems, and computer readable media for generating prefetching policies for rule caches associated with tagged processor architectures are provided. An example method occurs at a node for generating compartmentalization security policies for tagged processor architectures. The method comprises: receiving computer code of at least one application; determining, using a compartmentalization algorithm, at least one rule cache characteristic, and performance analysis information, compartmentalizations for the computer code and rules for enforcing the compartmentalizations; generating a compartmentalization security policy comprising the rules for enforcing the compartmentalizations; and instantiating, using a policy compiler, the compartmentalization security policy for enforcement in the tagged processor architecture, wherein instantiating the compartmentalization security policy includes tagging an image of the computer code of the at least one application based on the compartmentalization security policy. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/113254 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/577 (20130101) Original (OR) Class G06F 2221/033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281437 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald A. Davis (Las Cruces, New Mexico); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | A multiplicative analog frequency transform optical neural network (MAFT-ONN) encodes data in the frequency domain, achieves matrix-vector products in a single shot using photoelectric multiplication, and uses a single electro-optic modulator for the nonlinear activation of all neurons in each layer. Photoelectric multiplication between radio frequency (RF)-encoded optical frequency combs allows single-shot matrix-vector multiplication and nonlinear activation, leading to high throughput and ultra-low latency. This frequency-encoding scheme can be implemented with several neurons per hardware spatial mode and allows for an arbitrary number of layers to be cascaded in the analog domain. For example, a three-layer DNN can compute over four million fully analog operations and implement both a convolutional and fully connected layer. Additionally, a MAFT-ONN can perform analog DNN inference of temporal waveforms like voice or radio signals, achieving bandwidth-limited throughput, speed of light-limited latency, and fully analog complex-valued matrix operations. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/149249 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/065 (20230101) G06N 3/0675 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281454 | Savvides et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marios Savvides (Pittsburgh, Pennsylvania); Dipan Kumar Pal (Pittsburgh, Pennsylvania) |
| ABSTRACT | During training of deep neural networks, a Copernican loss (LC) is designed to augment a primary loss function, for example, a standard Softmax loss, to explicitly minimize intra-class variation and simultaneously maximize inter-class variation. Copernican loss operates using the cosine distance and thereby affects angles leading to a cosine embedding, which removes the disconnect between training and testing. |
| FILED | Monday, April 10, 2023 |
| APPL NO | 18/132509 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281490 | BEHANDISH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Morad BEHANDISH (San Mateo, California); John MAXWELL, III (Santa Clara, California); Johan de Kleer (Los Altos, California) |
| ABSTRACT | Methods and systems useful for artificial intelligence-assisted generation of viable hypotheses may have (1) an ability to rapidly enumerate and test a diverse set of mathematically sound and parsimonious physical hypotheses, starting from a few basic assumptions on the embedding spacetime topology; (2) a distinction between non-negotiable mathematical truism (e.g., conservation laws or symmetries), that are directly implied by properties of spacetime, and phenomenological relations (e.g., constitutive laws), whose characterization relies indisputably on empirical observation, justifying targeted use of data-driven methods (e.g., machine learning (ML) or polynomial regression); and (3) a “simple-first” strategy (following Occam’s razor) to search for new hypotheses by incrementally introducing latent variables that are expected to exist based on topological foundations of physics. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 17/684100 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/041 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281950 | Niedermeyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy M. Niedermeyer (Tacoma, Washington); Carmen K. Tseng (Tigard, Oregon); Steven C. Stowe (Tigard, Oregon) |
| ABSTRACT | A system and method for real-time image transformation monitoring for a display unit receives, via a pixel buffer, pixels of source image data and appends fiducial data to each pixel, the fiducial data corresponding to a reference checksum associated with a transformation map for one or more transformations of the source image into an output image for display. When source image data is read out of the pixel buffer, e.g., as a sequence of pixel datasets, an image transformation monitor extracts the fiducial data appended to each dataset and incorporates each set of extracted fiducial data into a checksum calculation for the current source image. When the transformed output image is complete, the cumulative checksum calculation for the current source image is compared to the reference checksum, determining a system status or detecting a system fault based on whether or not the checksum calculation and reference calculation are equivalent. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/685158 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 1/60 (20130101) G06T 7/0002 (20130101) G06T 2207/10016 (20130101) Image or Video Recognition or Understanding G06V 10/443 (20220101) Original (OR) Class G06V 2201/02 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282388 | Kashani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamzeh Kashani (Chandler, Arizona); Wonmo Kang (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hamzeh Kashani (Chandler, Arizona); Wonmo Kang (Scottsdale, Arizona) |
| ABSTRACT | A composite wire material may comprise a core wire comprising copper (Cu). The core wire material may comprise a first layer on a circumferential surface of the core wire, where the first layer comprises graphene. The composite wire material may comprise a second layer on a circumferential surface of the first layer, where the second layer comprises nickel (Ni). |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169320 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) H01B 1/026 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282734 | Goodman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Kevin D. Goodman (Ellettsville, Indiana) |
| ABSTRACT | Provided is a cadmium selenide-indium arsenide heterojunction bipolar transistor. The device includes a first layer comprising a collector of the transistor made of n-type cadmium selenide, a base layer containing indium arsenide, and an emitter layer that reverts to cadmium selenide. The inventive device includes a large neutron cross section via the cadmium selenide layer. The cadmium selenide layer holds a high reaction rate with neutrons thus altering the electrical signal of the HBT in a neutron environment. The inventive HBT also yields higher gains than current homojunction bipolar transistors, such as those utilizing pure indium arsenide or silicon. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/684712 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/45 (20130101) H01L 29/267 (20130101) H01L 29/7371 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282975 | Dawson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Carlos Dawson (Lemon Grove, California) |
| ABSTRACT | A method for hybrid RF beamforming comprising: providing an antenna structure which comprises: a driven element, parasitic elements configured to couple/decouple a linearly polarized radiation pattern and arranged around the driven elements, a feed system comprising four ports that are 90 degrees out of phase with each other and are connected to the driven element, RF switches electrically connected to the parasitic elements and the four ports, and a controller operatively connected to the RF switches; selectively attenuating an output of each of the four ports with the controller according to a stored configuration, which is stored in a memory, by changing the four ports' respective phase or attenuation; and selectively changing a loading of each parasitic element by activating each parasitic element's corresponding RF switch with the controller according to the stored configuration so as to produce a desired null/beamforming of a main RF beam. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/685031 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/36 (20130101) Original (OR) Class H01Q 19/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230277981 | Morajkar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rohan Morajkar (Palo Alto, California) |
| ABSTRACT | A membrane assembly of an energy and vapor exchanger includes a gas-permeable membrane having a first major surface that faces a gas flow and a second major surface that faces a liquid desiccant flow. An inlet region is proximate an inlet edge of the gas-permeable membrane. The inlet region includes a vortex generator that creates a vortex in the gas flow as it moves from the inlet edge to an outlet edge of the gas-permeable membrane. The vortex enhances mixing of fluids along the gas-permeable membrane. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/684898 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 53/229 (20130101) Original (OR) Class B01D 53/263 (20130101) B01D 53/268 (20130101) B01D 69/02 (20130101) B01D 69/04 (20130101) B01D 69/06 (20130101) B01D 71/36 (20130101) B01D 2053/223 (20130101) B01D 2252/10 (20130101) B01D 2325/38 (20130101) Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/06 (20130101) Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 3/1417 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278014 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Di-Jia Liu (Elmhurst, Illinois); Tao Xu (Naperville, Illinois); Jianxin Wang (Chicago, Illinois) |
| ABSTRACT | Electrocatalysts composed of single atoms or metal clusters dispersed over porous carbon support were prepared by a lithium-melt method. The new catalysts demonstrated high selectivity, high Faradic efficiency and low overpotential toward to the electrocatalytic reduction of carbon dioxide to chemicals such as glycerol or isopropanol. |
| FILED | Monday, January 16, 2023 |
| APPL NO | 18/097439 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/14 (20130101) B01J 23/72 (20130101) B01J 23/78 (20130101) Original (OR) Class B01J 35/1028 (20130101) B01J 37/04 (20130101) B01J 37/0081 (20130101) B01J 37/0228 (20130101) Acyclic or Carbocyclic Compounds C07C 29/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278040 | Lacey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. Lacey (Ammon, Idaho); Blesson Isaac (Idaho Falls, Idaho) |
| ABSTRACT | A system for perforating containers may have a first rotor assembly with a first set of rotors arranged at least partway along a first shaft, and a second rotor assembly with a second set of rotors arranged along a second shaft. The system may further have a frame that rotatably supports the first rotor assembly and the second rotor assembly in a parallel arrangement such that the first set of rotors interdigitates with the second set of rotors. Each rotor of the first set of rotors and the second set of rotors may have a hub, and one or more lobes extending outward from the hub, each of which is shaped such that, during rotation of the first rotor assembly and the second rotor assembly, the lobes perforate the containers as the containers pass between the first rotor assembly and the second rotor assembly. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/684414 |
| CURRENT CPC | Crushing, Pulverising, or Disintegrating in General; Milling Grain B02C 18/142 (20130101) Original (OR) Class B02C 19/0093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278263 | Qiao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu Qiao (San Diego, California); Kiwon Oh (La Jolla, California); Haozhe Yi (La Jolla, California); Rui Kou (La Jolla, California) |
| ABSTRACT | The disclosure features systems, devices, and methods of sectioned compaction of composite materials for large parts. An example system includes a mold assembly, including a bottom wall, one or more side walls coupled to the bottom wall, one or more pistons, wherein the bottom wall, the one or more side walls, and the one or more pistons at least partially define a mold cavity, and wherein each of the one or more pistons are independently movable to reduce the volume of the mold cavity; and a plurality of fasteners configured to selectively immobilize the one or more pistons; and a compression actuator configured to sequentially advance the pistons from an initial position to an actuated position to compress a composite material within the mold cavity. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/925665 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/302 (20130101) Original (OR) Class B29C 33/308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278560 | Borhan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana); Compagnie Generale Des Etablissements Michelin (Clermont-Ferrand, France) |
| ASSIGNEE(S) | Cummins Inc. (Columbus, Indiana); Compagnie Generale Des Etablissements Michelin (Clermont-Ferrand, France) |
| INVENTOR(S) | Hoseinali Borhan (Bloomington, Indiana); Jingxuan Liu (Columbus, Indiana); Bibin N. Pattel (Columbus, Indiana); Robert Ciprian Radulescu (Greenville, South Carolina) |
| ABSTRACT | A method of operating an electronic control system of a vehicle includes determining a first braking distance to achieve a first speed of a first vehicle, receiving a second vehicle braking distance to achieve a second vehicle speed of a second vehicle forward of the first vehicle, determining a minimum following distance between the first vehicle and the second vehicle in response to the first braking distance and the second braking distance, and controlling operation of the vehicle with an autonomous control system using the minimum following distance. A computer-implemented fleet management system is configured to receive logistics objectives including load, timeline, and cost information for a freight delivery, receive fleet information including tire parameters of a plurality of vehicles of a fleet, and determine a plurality of trips and a corresponding vehicle selection in response to the logistics objectives and the fleet information. |
| FILED | Thursday, May 11, 2023 |
| APPL NO | 18/315822 |
| CURRENT CPC | Vehicle Brake Control Systems or Parts Thereof; Brake Control Systems or Parts Thereof, in General; Arrangement of Braking Elements on Vehicles in General; Portable Devices for Preventing Unwanted Movement of Vehicles; Vehicle Modifications to Facilitate Cooling of Brakes B60T 7/22 (20130101) B60T 2201/022 (20130101) B60T 2210/12 (20130101) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 10/18 (20130101) B60W 30/143 (20130101) B60W 30/165 (20130101) Original (OR) Class B60W 40/068 (20130101) B60W 60/001 (20200201) B60W 2530/20 (20130101) B60W 2552/40 (20200201) B60W 2554/802 (20200201) B60W 2554/804 (20200201) B60W 2556/65 (20200201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278874 | Azenkeng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Energy and Environmental Research Center Foundation (Grand Forks, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Azenkeng (Grand Forks, North Dakota); Jason D. Laumb (Grand Forks, North Dakota) |
| ABSTRACT | A method of forming graphite includes carbonizing an upgraded coal, to form a carbonized upgraded coal. The method also includes graphitizing the carbonized upgraded coal, to form the graphite. |
| FILED | Friday, April 28, 2023 |
| APPL NO | 18/309339 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/205 (20170801) Original (OR) Class C01B 2204/04 (20130101) C01B 2204/06 (20130101) Destructive Distillation of Carbonageous Materials for Production of Gas, Coke, Tar, or Similar Materials C10B 53/04 (20130101) C10B 57/08 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 5/04 (20130101) C10L 9/06 (20130101) C10L 2290/08 (20130101) C10L 2290/60 (20130101) C10L 2290/544 (20130101) C10L 2290/545 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 11/043 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278885 | Marsden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth C. Marsden (Idaho Falls, Idaho); Kevin D. Lamont (Idaho Falls, Idaho); Michael N. Patterson (Pocatello, Idaho) |
| ABSTRACT | A method of producing uranium chloride. The method comprises combining a uranium feedstock, a chlorinating agent, and a metal salt in a reaction vessel to form a reaction mixture. The reaction mixture is heated to a temperature of from about 600° C. to about 850° C. to form uranium chloride or a uranium chloride eutectic mixture. The uranium chloride or the uranium chloride eutectic mixture is separated from the reaction mixture. A composition comprising uranium chloride or a uranium chloride eutectic mixture at a purity of greater than about 99.9 is also disclosed, as are additional methods of producing uranium chloride. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177414 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 43/08 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278931 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Yuepeng ZHANG (Naperville, Illinois); John HRYN (Hawthorn Woods, Illinois); Gregory K. KRUMDICK (Homer Glen, Illinois); Jungkuk LEE (Bolingbrook, Illinois) |
| ABSTRACT | A method for preparing metal oxide and ceramic oxide nano- and microparticulate materials is described herein. The method comprises irradiating a precursor material with high energy pulsed-light flashes in an oxygen-containing atmosphere. The precursor materials comprise thin films, fibers, or particles of subnano-, nano-, or microscale dimension, which are composed of metal ions dispersed in an amorphous or partially crystalline polymer matrix in a ratio necessary to form target metal oxide or ceramic oxide when reacted with oxygen (i.e., the precursor material does not include any metal oxide phase). The irradiation of the precursor material in an oxygen-containing atmosphere decomposes and removes the polymers and anions from the precursor, and also oxidizes the metal ions within the precursor materials to form metal oxide or ceramic oxide particulates. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116158 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/62231 (20130101) Original (OR) Class C04B 35/62645 (20130101) C04B 35/63444 (20130101) C04B 41/0045 (20130101) C04B 41/0072 (20130101) C04B 2235/32 (20130101) C04B 2235/48 (20130101) C04B 2235/6583 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230278939 | Hanson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Hanson (Tallahassee, Florida); Thomas Edward Schoenzart (Tallahassee, Florida); Sahan Salpage (Tallahassee, Florida) |
| ABSTRACT | Provided herein are photochemical separations. The methods herein can include exposing a first metal complex and a second metal complex to light to facilitate an irreversible chemical reaction to form a modified first metal complex. The modified first metal complex then may be separated from the second metal complex. Compositions also are provided. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172731 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 63/02 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/003 (20130101) C07F 15/025 (20130101) C07F 15/0026 (20130101) C07F 15/0053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279194 | Abu-Omar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mahdi M. Abu-Omar (Santa Barbara, California); Manhao Zeng (Santa Barbara, California); Susannah Scott (Santa Barbara, California); Fan Zhang (Santa Barbara, California); Jiakai Sun (Santa Barbara, California); Yu-Hsuan Lee (Santa Barbara, California) |
| ABSTRACT | Process for upcycling a waste material to form alkylaromatic compounds is described herein. The process typically includes the steps of feeding a waste material containing hydrocarbon polymer(s) into a reactor containing a catalyst therein, and operating the reactor at a sufficient temperature for a sufficient period of time to convert the hydrocarbon polymer(s) to a liquid and/or wax product containing alkylaromatic compound(s). Each of the alkylaromatic compound(s) contains at least 10 carbon atoms. The catalyst contains a transition metal or a mixture of a transition metal and another metal. Optionally, the catalyst is dispersed on the surface of a support. The product may contain other unsaturated compounds, such as olefins. Typically, the reactor operates at a temperature in the range between 250° C. and 350° C. The total selectivity of the process to form the one or more alkylaromatic compounds is typically between 50 mol % and 95 mol %. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 18/005830 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 4/18 (20130101) C07C 2521/04 (20130101) C07C 2523/42 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/16 (20130101) Original (OR) Class C08J 2323/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279572 | Akolkar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rohan Akolkar (Cleveland, Ohio) |
| ABSTRACT | A process for production of metal(s) by molten-salt electrolysis includes direct non-carbothermic chlorinating of ore containing metal oxide(s) to produce metal chloride(s); and electrolysis of molten salt(s) of the metal chloride(s) for electrowinning of metal(s) product. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054277 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/22 (20130101) Original (OR) Class C25C 7/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279582 | Britt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MATRIX SENSORS, INC. (San Diego, California) |
| ASSIGNEE(S) | MATRIX SENSORS, INC. (San Diego, California) |
| INVENTOR(S) | David K Britt (El Cerrito, California); Paul R Wilkinson (El Segundo, California); Steven Yamamoto (San Diego, California) |
| ABSTRACT | An apparatus and method is provided for coating a surface of a material with a film of porous coordination polymer. A first substrate having a first surface to be coated is positioned in a processing chamber such that the first surface is placed in a substantially opposing relationship to a second surface. In some embodiments, the second surface is provided by a wall of the processing chamber, and in other embodiments the second surface is provided by a second substrate to be coated. The first substrate is held such that a gap exists between the first and second surfaces, and the gap is filled with at least one reaction mixture comprising reagents sufficient to form the crystalline film on at least the first surface. A thin gap (e.g., having a thickness less than 2 mm) between the first and second surfaces is effective for producing a high quality film having a thickness less than 100 μm. Confining the volume of the reaction mixture to a thin layer adjacent the substrate surface significantly reduces problems with sedimentation and concentration control. In some embodiments, the size, shape, or average thickness of the gap is adjusted during formation of the film in response to feedback from at least one film growth monitor. |
| FILED | Saturday, April 01, 2023 |
| APPL NO | 18/129829 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/00 (20130101) C07F 15/04 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 28/04 (20130101) Original (OR) Class C30B 29/58 (20130101) Weighing G01G 3/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279780 | Trivedi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deepak Trivedi (Niskayuna, New York); Rahul Anil Bidkar (Niskayuna, New York); Uttara Vijay Kumar (Glenville, New York) |
| ABSTRACT | A seal assembly for a component of a turbomachine and method of assembly thereof is provided. The seal assembly includes at least one mating face positioned adjacent to the component and a seal coupled to the mating face. The seal includes an outer shell defining an interior space; an inner matrix filling the interior space comprising a plurality of unit cells comprising one or more metamaterials, wherein at least a portion of the plurality of unit cells are identical, and wherein the plurality of unit cells are repeated throughout the inner matrix; and one or more support struts extending throughout the inner matrix. The method of building the seal assembly may include selecting a first material for the outer shell and selecting the one or more metamaterials for the inner matrix based on the first material. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/685953 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/001 (20130101) Original (OR) Class F01D 11/04 (20130101) F01D 25/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280104 | ZIDAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RAGAIY ZIDAN (AIKEN, South Carolina) |
| ABSTRACT | Disclosed are thermal energy storage systems and methods that utilize metal carbonate eutectics that can undergo high temperature reversible reactions to form mixtures of metal oxides. The metal oxides undergo an exothermic reaction with carbon dioxide to form the molten metal carbonate eutectics, and the molten metal carbonate eutectics undergo an endothermic decarbonization reaction to form the metal oxides and carbon dioxide. By carrying out the reversible reactions at a temperature above the melting point of the carbonate eutectic, the systems provide high thermal conductivity and reversible stability for thermal energy storage. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/686568 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/24 (20130101) B01J 2208/00194 (20130101) Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 7/00 (20130101) C01D 15/08 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/0034 (20130101) Original (OR) Class F28D 2020/0047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280254 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aerosol Dynamics Inc. (Berkeley, California); Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Aerosol Dynamics Inc. (Berkeley, California); Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Jian Wang (St. Louis, Missouri); Steven Russel Spielman (Oakland, California); Jiaoshi Zhang (St. Louis, Missouri); Susanne Vera Hering (Berkeley, California); Jing Li (St. Louis, Missouri) |
| ABSTRACT | A system and method to measure a size distribution of particles based on their electrical mobility. The method includes: introducing, via a sheath flow inlet, a particle free sheath flow into a chamber formed by two parallel walls which are separated by a gap, the chamber having a width and a length, the sheath flow having a direction along the length of the chamber and flowing a laminar manner; introducing an aerosol sample flow into the chamber downstream of the sheath inlet such that the aerosol sample flow joins the particle free sheath flow in a laminar manner; applying an electric field between the two parallel walls of the chamber, the field having a strength which varies across the width of the chamber; extracting an output aerosol flow through a first outlet downstream of the sample inlet; and outputting an excess flow equal to a sum of the sheath flow and aerosol sample flow minus the output aerosol flow. The method may also include: passing the output aerosol flow through a growth cell in a laminar manner, the growth cell having a region of wetted walls with two or more temperature regions such that the particles within the output aerosol flow grow by condensation to form droplets, and such that relative positions of droplets are indicative of particle electrical mobility; and counting and capturing a spatial position of individual droplets exiting the growth cell. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160948 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2202 (20130101) G01N 15/0266 (20130101) Original (OR) Class G01N 2001/2223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280656 | FRANK |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| INVENTOR(S) | Yechiel R. FRANK (Livermore, California) |
| ABSTRACT | An EUV light source including a vacuum chamber, a droplets injector operatively connected to the vacuum chamber for directing the droplets into the vacuum chamber, droplets produced by the droplets injector wherein the droplets have one side and another side opposite the one side, the droplets including a solid higher Z bead in a low Z liquid, and at least one laser beam directed onto the one side of the droplets. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 18/008147 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/70033 (20130101) Original (OR) Class G03F 7/70841 (20130101) X-ray Technique H05G 2/005 (20130101) H05G 2/006 (20130101) H05G 2/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281749 | Fedorov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ViQi, Inc. (Santa Barbara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dmitry Fedorov (Santa Barbara, California); Christian A. Lang (Santa Barbara, California); Kristian Kvilekval (Santa Barbara, California); Ilya Goldberg (Santa Barbara, California) |
| ABSTRACT | Methods, apparatus, and systems for high-resolution image storage and analysis are disclosed. In one disclosed embodiment, a method includes analyzing a high-resolution image; partitioning the high-resolution image into logical blocks; detecting objects in the high-resolution image within the logical blocks, assigning objects that differ or with differing measures to differing layers, and assigning objects that are similar or with similar measures to the same layer; tabulating the detected objects into a table, wherein each row indicates a spatial position of each detected object and at least one measure of each detected object; storing the spatial position and the at least one measure of each detected object into the table; spatially rendering selected objects over the high-resolution image; and displaying the selected objects at a selected resolution within a portion of the high-resolution image on a display device. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089561 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 1/60 (20130101) Original (OR) Class G06T 3/40 (20130101) G06T 5/50 (20130101) G06T 7/11 (20170101) G06T 7/70 (20170101) G06T 2207/10056 (20130101) G06T 2207/20221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282311 | Behsaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bahar Behsaz (Pasadena, California); Liu Cao (Pittsburgh, Pennsylvania); Mustafa Guler (Pittsburgh, Pennsylvania); Yi-Yuan Lee (Ithaca, New York); Hosein Mohimani (Pittsburgh, Pennsylvania); Mihir Mongia (Pittsburg, Pennsylvania); Donghui Yan (Pittburgh, Pennsylvania) |
| ABSTRACT | A method and system is for receiving data representing gene clusters, the gene clusters including one or more genes configured to encode one or more polypeptides or other small molecules; accessing a machine learning model, the machine learning model being trained with a training dataset that associates the gene clusters to structures of one or more small molecules represented in the data; applying the machine learning model to the data representing the gene clusters; identifying, based on applying the machine learning model, one or more monomers associated with at least one gene cluster represented in the data; and determining a structure for a natural product including the one or more monomers. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/076280 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282375 | Lange et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); WALSH Engineering Services, PC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis L. Lange (Idaho Falls, Idaho); Yasir Arafat (Idaho Falls, Idaho); Benjamin A. Baker (Ammon, Idaho); Stanley Blaine Grover (Idaho Falls, Idaho); Jeffrey Donald Jones (Idaho Falls, Idaho); Lucas Avery Andrew (Idaho Falls, Idaho); Mathew Ryan Floyd (Pocatello, Idaho); Kyle Bruce Francis (Idaho Falls, Idaho); Tarrin Scott Funderburg (Idaho Falls, Idaho) |
| ABSTRACT | A Control Neutron Absorber (CNA) assembly for a microreactor that produces nuclear energy is disclosed. The CNA assembly includes a housing, a CNA rod, and a burnable absorber. The housing includes an inner housing and an outer housing. The inner housing is configured to receive a CNA rod. The outer housing extends coaxially with the inner housing and is positioned radially outward and offset from the inner housing defining a cavity therebetween. The CNA rod includes a neutron absorbing rod including a first neutron absorbing material. The neutron absorbing rod is positioned within the inner housing and is configured to move axially relative to the inner housing. The burnable absorber includes a second neutron absorbing material, exhibits a neutron absorbing strength that is less than that of the neutron absorbing rod, is positioned within the inner housing, and is configured to receive the neutron absorbing rod therein. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/179251 |
| CURRENT CPC | Nuclear Reactors G21C 7/103 (20130101) Original (OR) Class G21C 17/112 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282378 | Tripathy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabhat K. Tripathy (Idaho Falls, Idaho) |
| ABSTRACT | A method of direct oxide reduction includes forming a molten salt electrolyte in an electrochemical cell, disposing at least one metal oxide in the electrochemical cell, disposing a counter electrode comprising a material selected from the group consisting of osmium, ruthenium, rhodium, iridium, palladium, platinum, silver, gold, lithium iridate, lithium ruthenate, a lithium rhodate, a lithium tin oxygen compound, a lithium manganese compound, strontium ruthenium ternary compounds, calcium iridate, strontium iridate, calcium platinate, strontium platinate, magnesium ruthenate, magnesium iridate, sodium ruthenate, sodium iridate, potassium iridate, and potassium ruthenate in the electrochemical cell, and applying a current between the counter electrode and the at least one metal oxide to reduce the at least one metal oxide. Related methods of direct oxide reduction and related electrochemical cells are also disclosed. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/183675 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 3/34 (20130101) C25C 3/36 (20130101) C25C 7/025 (20130101) Nuclear Reactors G21C 19/48 (20130101) Original (OR) Class G21C 19/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282383 | Xiong |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yongliang Xiong (Albuquerque, New Mexico) |
| ABSTRACT | A container holds radioactive material. A sub-criticality controller protects the radioactive material from reaching a criticality from contact with the water. The sub-criticality controller includes a metallic composition having at least one metal component and at least one borate component bonded to the at least one metal component. The metallic composition forms borates from the borate component when the metallic composition contacts the water. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/114340 |
| CURRENT CPC | Nuclear Reactors G21C 19/40 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 9/22 (20130101) G21F 9/24 (20130101) Original (OR) Class G21F 9/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282426 | Brambilla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FastCAP Systems Corporation (Wakefield, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolo Michele Brambilla (Boston, Massachusetts); Fabrizio Martini (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein is electrode comprising a current collector comprising a conductor layer having at least a first surface; and elongated metal carbide nanostructures extending from the first surface; and a carbonaceous energy storage media disposed on the first surface and in contact with the elongated metal carbide nanostructures. Disclosed herein too is an ultracapacitor comprising at least one electrode comprising a current collector comprising a conductor layer having at least a first surface; and elongated metal carbide nanostructures extending from the first surface; and a carbonaceous energy storage media disposed on the first surface and in contact with the elongated metal carbide nanostructures. |
| FILED | Tuesday, April 25, 2023 |
| APPL NO | 18/139008 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/158 (20170801) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/26 (20130101) H01G 11/28 (20130101) H01G 11/36 (20130101) Original (OR) Class H01G 11/46 (20130101) H01G 11/48 (20130101) H01G 11/70 (20130101) H01G 11/86 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282804 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kuan-Hung Chen (Ann Arbor, Michigan); Neil Dasgupta (Ann Arbor, Michigan); Jeffrey Sakamoto (Ann Arbor, Michigan); Min Ji Namkoong (Ann Arbor, Michigan) |
| ABSTRACT | A lithium-ion battery includes an electrode with a plurality of channels formed at least partially through its thickness. Each channel has a diameter in a range from 5 μm to 100 μm and/or is spaced apart from another channel by a distance in a range from 10 μm to 200 μm as measured between centerlines of the channels. The electrode may be an anode and includes carbonaceous material such as graphite and/or additional electrochemically active lithium host materials. The battery can be charged at a C-rate greater than 2 C. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/121525 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 50/46 (20210101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282808 | KETABI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Sanaz KETABI (Rochester Hills, Michigan); Shuru CHEN (Troy, Michigan); Fang DAI (Troy, Michigan); Mei CAI (Bloomfield Hills, Michigan) |
| ABSTRACT | A method for forming a protective electrode coating on an electrode to be used in a lithium-sulfur battery is provided. The method includes contacting one or more surfaces of the electrode with a polymeric admixture, and polymerizing the polymeric admixture to form the protective electrode coating. The polymeric admixture includes a plurality of monomers, for example heterocyclic acetal monomers and/or cyclic ether monomers, and a lithium difluoro(oxalato)borate (LiDFOB) initiator. In certain instances, the polymeric admixture may also include a structural additive and/or a lithium salt. The contacting may include applying a thin film on the one or more surfaces of the electrode, and the polymerization may be heat activated. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688163 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/382 (20130101) H01M 4/628 (20130101) H01M 4/5815 (20130101) H01M 4/5825 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282816 | Fayette et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Matthew R. Fayette (Richland, Washington); Xiaolin Li (Richland, Washington); David M. Reed (Richland, Washington) |
| ABSTRACT | Indium zinc-based alloy anodes include an InxMyZnz alloy, where x ranges from 0.03 to 0.20, z ranges from 0.80 to 0.97, and x+y+z=1 when the anode has not previously been cycled. M is Al, Ag, Bi, Sn, Cd, or any combination thereof. In a partially or fully discharged state after one or more cycles, the anode includes a porous surface portion enriched in indium and a bulk portion comprising the InxMyZnz alloy. In a subsequent partially or fully charged state, the pores may be at least partially filled with zinc. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177586 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/42 (20130101) Original (OR) Class H01M 4/60 (20130101) H01M 4/0404 (20130101) H01M 4/0452 (20130101) H01M 10/36 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282820 | THACKERAY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Michael M. THACKERAY (Naperville, Illinois); Eungje LEE (Naperville, Illinois); Jason R, CROY (Plainfield, Illinois); Boyu SHI (Willowbrook, Illinois) |
| ABSTRACT | Stabilized lithium- and manganese rich manganese-nickel-oxide electrode materials for Li-ion batteries with structurally-integrated layered, lithiated spinel- and rock salt components are described, as are methods to synthesize them. In these methods, selected annealing temperatures and times are used to control the amount of a stabilizing lithiated spinel component, as well as the extent of disorder in the composite electrode structure to optimize electrochemical performance. The stabilized lithium- and manganese rich manganese-nickel-oxide electrode materials can be structurally-integrated with other lithium-metal-oxide or lithium-metal-polyanionic components, as well. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/121785 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/50 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/32 (20130101) C01P 2002/52 (20130101) C01P 2002/72 (20130101) C01P 2004/04 (20130101) C01P 2004/80 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/505 (20130101) Original (OR) Class H01M 4/525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282837 | Archer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lynden A. Archer (Ithaca, New York); Jingxu Zheng (Shenzen, China PRC); Jiefu Yin (Ithaca, New York) |
| ABSTRACT | In various examples, an anode, which may be for a metal ion-conducting electrochemical device, comprises a metal member; and a metal conducting coating, which may be an epitaxial (e.g., a homoepitaxial) metal conducing coating, disposed on at least a portion of the metal member (e.g., all portions of the metal member that would be or are in contact with the electrolyte of the metal ion-conducting electrochemical device). A metal conducting coating or an anode may be formed by electrodeposition in the presence of a field. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 18/008384 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 11/069 (20210101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/04 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/005 (20130101) C30B 7/12 (20130101) C30B 29/02 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/30 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0452 (20130101) H01M 4/626 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230283036 | Payne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Anthony Payne (Castro Valley, California); Raymond Beach (Livermore, California); Jean-Michel Di Nicola (Livermore, California); Alvin Erlandson (Livermore, California); John Heebner (San Ramon, California); Jeremy Lusk (Livermore, California); William A. Molander (Livermore, California); Samuel Edward Schrauth (Livermore, California); Jen Nan Wong (Fremont, California) |
| ABSTRACT | An optical amplifier comprises a gain medium having an input surface and an output surface wherein the output surface is larger than the input surface. The gain medium may be frustum shaped. The optical amplifier includes a negative diverging lens to receive an extraction laser beam and to cause the laser beam to expand as the beam passes through the gain medium. The amplifier further comprises a positive collimating lens configured to receive the expanding amplified beam and reduce the divergence. The gain medium can be pumped by counter-propagating radiation. The fluence of the laser beam within the gain medium is configured to be near constant along the length of the gain medium and may be within 1.5-2.0 FSAT. The gain medium may be doped with dopant to provide gain, with larger concentration of dopants proximal the input surface and smaller concentration proximal the output surface. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/687467 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/165 (20130101) H01S 3/0606 (20130101) H01S 3/1611 (20130101) H01S 3/08059 (20130101) H01S 3/094038 (20130101) Original (OR) Class H01S 2301/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230283079 — Wind turbine power phase control with DC collection bus for onshore/offshore windfarms
| US 20230283079 | Weaver et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Alubquerque, New Mexico); Michigan Technological University (Houghton, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne W. Weaver (Hancock, Michigan); David G. Wilson (Tijeras, New Mexico); Rush D. Robinett, III (Tijeras, New Mexico) |
| ABSTRACT | A DC bus collection system for a wind farm reduces the overall required number of converters and minimizes the energy storage system requirements. The DC bus collection system implements a power phasing control method between wind turbines that filters the variations and improves power quality. The phasing control method takes advantage of a novel power packet network concept with nonlinear power flow control design techniques that guarantees both stable and enhanced dynamic performance. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/684665 |
| CURRENT CPC | Wind Motors F03D 9/11 (20160501) F03D 9/257 (20170201) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/381 (20130101) Original (OR) Class H02J 2300/28 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230284468 | ZHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai ZHU (Littleton, Colorado); Qi JIANG (Golden, Colorado); Jinhui TONG (Wuhan, China PRC) |
| ABSTRACT | The present disclosure relates to a device that includes a layer that includes a perovskite, where the layer has a first side and a second side defining a thickness, the perovskite has a bulk composition as defined by AB(X1-yXy′)3, where A includes a first cation, B includes a second cation, X includes iodide, and X′ includes bromide, y is between 0.2 and 0.8, inclusively, and the thickness has a bromide concentration gradient across the thickness with a maximum concentration at or in the proximity of the first side and a minimum concentration at the second side. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177232 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/0036 (20130101) H01G 9/2009 (20130101) Organic electric solid-state devices H10K 30/57 (20230201) Original (OR) Class H10K 71/16 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230277049 | von Wendorff |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior Univerity (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Anna Sophie von Wendorff (Loomis, California) |
| ABSTRACT | Endoscope systems with detachable scopes in accordance with embodiments of the invention are disclosed. In one embodiment of the invention, an endoscope system comprises an endoscope body and a detachable scope. The endoscope body comprises a cable capable of transmitting image data to a computing system, and a body connector. The detachable scope comprises a scope connector configured to couple with the body connector, and a tip, comprising an illumination module and an image sensor, wherein image data produced by the image sensor is transmitted to the endoscope body via the scope connector. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/179066 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/051 (20130101) A61B 1/053 (20130101) Original (OR) Class A61B 1/0669 (20130101) A61B 1/0684 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277057 | Maharbiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michel M. Maharbiz (El Cerrito, California); Jose M. Carmena (Berkeley, California); Dongjin Seo (Albany, California); Monica Lin (San Francisco, California); Meir Marmor (Oakland, California); Safa Herfat (Oakland, California); Chelsea Shields Bahney (Oakland, California) |
| ABSTRACT | Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/111499 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0031 (20130101) Original (OR) Class A61B 5/076 (20130101) A61B 5/279 (20210101) A61B 5/686 (20130101) A61B 6/4258 (20130101) A61B 8/48 (20130101) A61B 8/085 (20130101) A61B 8/0808 (20130101) A61B 8/0875 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 39/0208 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3605 (20130101) A61N 1/3787 (20130101) A61N 1/37205 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277096 | Fine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse M. Fine (College Station, Texas); Gerard L. Coté (College Station, Texas); Michael J. McShane (College Station, Texas) |
| ABSTRACT | In an embodiment, the present disclosure pertains to an analyte detection system. In some embodiments, the system includes a biosensor operable to be implanted into a media and a transmitter having a light source. In some embodiments, the transmitter is operable to be external to the media and operable to receive photoluminescence outputs back from the biosensor to determine properties of an analyte. In an additional embodiment, the present disclosure pertains to an analyte detection system. In some embodiments, the system includes a biosensor operable to be implanted into a media and a transmitter having a light source. In some embodiments, the transmitter is operable to be external to the media and operable to receive photoluminescence outputs back from the biosensor to determine properties of analytes. In a further embodiment, the present disclosure pertains to a biosensor having a plurality of discrete compartments in a barcode configuration. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/115587 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1451 (20130101) A61B 5/14532 (20130101) Original (OR) Class A61B 5/14865 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277098 | Kivi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Storx Technologies, Inc. (Davis, California) |
| ASSIGNEE(S) | Storx Technologies, Inc. (Davis, California); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Golnaz Alipour Kivi (San Diego, California); Soheil Ghiasihafezi (Davis, California) |
| ABSTRACT | Systems and methods are described, and one method includes determining a fetal blood oxygenation level, including: activating at least one light source with at least two distinct wavelengths of light on an abdomen of a pregnant mammal to direct light into a maternal abdomen toward a fetus; receiving a set of mixed signals from a set of photodetectors positioned at different locations on the maternal abdomen from reflected light that traverses maternal tissue or maternal tissue and fetal tissue; determining the fetal blood oxygenation level by performing computations on a composite fetal signal produced from the mixed signals; and ensuring a skin temperature of the maternal abdomen does not rise to unsafe levels due to activating the at least one light source. |
| FILED | Wednesday, May 10, 2023 |
| APPL NO | 18/315057 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/0064 (20130101) A61B 5/725 (20130101) A61B 5/02411 (20130101) A61B 5/4362 (20130101) A61B 5/6823 (20130101) A61B 5/14542 (20130101) Original (OR) Class A61B 2562/0271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277159 | ZHAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanhe ZHAO (Cambridge, Massachusetts); Xiaoyu CHEN (Cambridge, Massachusetts); Chonghe WANG (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods are provided for on-person wearable electronic devices configured for extended periods of wear. A couplant may be provided that is made of a soft anti-dehydrating, and hydrogel-elastomer hybrid material. A bioadhesive may connect the couplant the electronic devices and the person. The couplant may serve as a coupling and transmission for information to or from the electronic device. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/117738 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4236 (20130101) Original (OR) Class A61B 8/4494 (20130101) A61B 2562/12 (20130101) A61B 2562/164 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277456 | Peruzzi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin Alexander Peruzzi (Evanston, Illinois); Neha Prashant Kamat (Evanston, Illinois); Jan Steinkuehler (Evanston, Illinois) |
| ABSTRACT | The present disclosure provides methods and compositions for controlling the localization of proteins in lipid structures. The disclosure also provides methods for selecting appropriate proteins for desired localization and distribution in lipid structures based on hydrophobic thickness. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 18/054131 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) Original (OR) Class A61K 9/1275 (20130101) A61K 9/1278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277472 | XIE |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin XIE (Watkinsville, Georgia) |
| ABSTRACT | Disclosed are particles comprising lithium salts and methods for their use in treating inflammatory conditions. |
| FILED | Friday, April 07, 2023 |
| APPL NO | 18/297365 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 9/5161 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277634 | Martino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cameron Martino (La Jolla, California); Benjamin Kellman (La Jolla, California); Nathan Lewis (La Jolla, California); Robin Knight (La Jolla, California); Jeffrey D. Esko (La Jolla, California); Daniel Sandoval (La Jolla, California); Thomas Mandel Clausen (La Jolla, California) |
| ABSTRACT | Methods and compositions for diagnosing, preventing or treating a viral infection in a subject comprising administering to a subject in need thereof an effective amount of a glycosidase or a sulfatase to degrade a glycan, such as heparan sulfate, to inhibit viral infection, such as COVID-19. Methods for identifying a glycosidase, a sulfatase, or a microbe associated with increased susceptibility to viral infection in a subject. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 18/005816 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 38/51 (20130101) Original (OR) Class A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) C12Q 1/34 (20130101) C12Q 1/527 (20130101) Enzymes C12Y 301/06013 (20130101) C12Y 301/06014 (20130101) C12Y 402/02007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279040 | Eagan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ascribe Bioscience Inc. (Ithaca, New York) |
| ASSIGNEE(S) | Ascribe Bioscience Inc. (Ithaca, New York) |
| INVENTOR(S) | James Eagan (Ithaca, New York) |
| ABSTRACT | This application relates to efficient methods for the synthesis of ascarylose and its derivatives. A method for the production of ascarylose includes: providing, as a feedstock, a 1-O-substituted rhamnose; forming a mono-sulfonate ester at the 3—OH group of the 1-O-substituted rhamnose; and treating the mono-sulfonate ester with a hydride source to form a 1-O-substituted ascarylose. Forming the mono-sulfonate ester can advantageously be conducted on a 1-O-substituted rhamnose without hydroxyl protecting groups at either the 2—OH or 4—OH—positions. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 18/007435 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/04 (20130101) C07H 15/10 (20130101) C07H 15/207 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279170 | Hua |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duy H. Hua (Manhattan, Kansas) |
| ABSTRACT | Synthesis of chiral polyvinylpyrrolidinone (CSPVP) compounds, complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and selective C—H bond oxidation reactions utilizing such complexes are disclosed. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177488 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/44 (20130101) B01J 23/52 (20130101) B01J 23/72 (20130101) B01J 35/0013 (20130101) B01J 37/0072 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 226/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279356 | Morgan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey R. Morgan (Sharon, Massachusetts); Benjamin T. Wilks (Boston, Massachusetts) |
| ABSTRACT | Described herein are in vitro quantitative methods directed to 3D extracellular matrix (ECM) organization and mechanics. The methods do not require application of an external force, anchorage, or a scaffolding material in order to culture ECM tissue constructs, and the methods enable quantitative measurements without crosstalk noise from variables attributable to external forces, anchorage, and scaffolding material. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/175417 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0656 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/727 (20130101) C12N 2503/02 (20130101) C12N 2513/00 (20130101) C12N 2527/00 (20130101) C12N 2533/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279406 | WONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | Wilson Wai Chun WONG (Brookline, Massachusetts); Yage DING (Allston, Massachusetts) |
| ABSTRACT | The technology described herein is directed to inducible and repressible polypeptides and polypeptide systems. In particular, described herein are split sequence-specific nucleases and split recombinases that are linked to drug-inducible or drug-repressible dimerization domains. In some embodiments, the polypeptides comprise sequestering domains and/or have their expression controlled by an inducible promoter. In multiple aspects described herein are polynucleotides, vectors, cells, and pharmaceutical compositions comprising said polypeptides or polypeptide systems. Also described herein are methods of using said polypeptide systems to modulate the expression of a target polypeptide or to treat a subject in need of a cell therapy. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066482 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1241 (20130101) C12N 15/63 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279460 | Jewett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Jessica Carol Stark (Evanston, Illinois); Matthew P. DeLisa (Ithaca, New York); Thapakorn Jaroentomeechai (Ithaca, New York) |
| ABSTRACT | Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/065689 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/04 (20130101) A61K 38/16 (20130101) A61K 39/0208 (20130101) A61K 39/0258 (20130101) Peptides C07K 7/06 (20130101) C07K 9/00 (20130101) C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 9/10 (20130101) C12N 9/1081 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) C12P 21/005 (20130101) Original (OR) Class Enzymes C12Y 204/99019 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279464 | Bandi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chandra Kanth Bandi (Piscataway, New Jersey); Shishir Chundawat (Piscataway, New Jersey); Kyle S. Skalenko (Piscataway, New Jersey) |
| ABSTRACT | The present disclosure provides, in one aspect, an azide-inducible system for controlled gene expression in E. coli. In another aspect, the present disclosure provides a high throughput screening method for the identification of new glycosynthases (e.g., mutant glycosyl hydrolases) with enhanced activity and unique substrate specificity. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 18/010109 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 2800/101 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/40 (20130101) Original (OR) Class C12Q 1/6897 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230279484 | Daugharthy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan R. Daugharthy (Cambridge, Massachusetts); Richard C. Terry (Carlisle, Massachusetts); Je-Hyuk Lee (Allston, Massachusetts); George M. Church (Brookline, Massachusetts); Benjamin W. Pruitt (Cambridge, Massachusetts) |
| ABSTRACT | Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix of nucleic acids is provided. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/956892 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6841 (20130101) C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280115 | Winter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Rebecca L. Winter (Lakewood, Ohio); Emre Olceroglu (San Francisco, California); Matthew McCarthy (Media, Pennsylvania) |
| ABSTRACT | A structure for enhancing condensation and wetting dynamics includes a substrate and a plurality of grooves formed in the substrate, forming fins. The fins having fin tops and a coating is applied over the fin tops. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/116335 |
| CURRENT CPC | Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/187 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280294 | Smith |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Innogized Techologies Inc. (Chesterland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oliver Smith (Chesterland, Ohio) |
| ABSTRACT | Systems, methods, devices, and circuitries are provided for determining a material property. In one embodiment, a method includes applying non-thermal energy to a first side of a material sample; sensing, a response of the material sample to the non-thermal energy; generating non-thermal data indicative of the response; and determining a thermal property of the material sample based on the non-thermal data. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/105976 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 7/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/08 (20130101) G01N 21/00 (20130101) G01N 25/18 (20130101) Original (OR) Class G01N 25/22 (20130101) G01N 2015/0846 (20130101) G01N 2291/02827 (20130101) G01N 2291/02854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280343 | Montclare et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin Kim Montclare (New York, New York); Farbod Mahmoudinobar (Harrison, New Jersey); Kamia Punia (Staten Island, New York); Dustin Robert Britton (Brooklyn, New York) |
| ABSTRACT | Provided is a multivalent protein that targets interaction of SARS-CoV-2 spike receptor binding domain (RBD) with the human angiotensin-converting enzyme 2 (ACE2) receptor protein. The multivalent proteins may also be used to treat subjects having cancer and/or a disease and/or viral infection. Also presented is a multiplex lateral flow test strips for simultaneous detection of the virus and viral antibodies. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 18/058703 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/78 (20130101) C07K 2319/50 (20130101) Enzymes C12Y 304/17023 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54388 (20210801) G01N 33/56983 (20130101) Original (OR) Class G01N 2469/10 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281047 | Mishra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabhat Kumar Mishra (Gainesville, Florida); Zhixin Pan (Gainesville, Florida) |
| ABSTRACT | Various embodiments provide methods, apparatuses, computer program products, systems, and/or the like for an efficient framework that enables explainability machine learning for various machine learning-based tasks. In various embodiments, the framework for explainable ML is configured for acceleration and efficient computing using hardware accelerators. To provide acceleration of explainable ML, various embodiments exploit synergies between convolution operations for data objects (e.g., matrix, images, tensors, arrays) and Fourier transform operations, and various embodiments apply these synergies in hardware accelerators configured to perform such operations. Accordingly, various embodiments of the present disclosure may be applied in order to provide real-time or near real-time outcome interpretation in various machine learning-based tasks. Extensive experimental evaluations demonstrate that various embodiments described herein can provide drastic improvement in interpretation time (e.g., 39× on average) as well as energy efficiency (e.g., 69× on average) compared to existing techniques. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/178945 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5027 (20130101) Original (OR) Class G06F 15/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281319 | DeHon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andre Maurice DeHon (Philadelphia, Pennsylvania); Nicholas Edward Roessler (Philadelphia, Pennsylvania) |
| ABSTRACT | Methods, systems, and computer readable media for generating compartmentalization security policies and/or methods, systems, and computer readable media for generating prefetching policies for rule caches associated with tagged processor architectures are provided. An example method occurs at a node for generating compartmentalization security policies for tagged processor architectures. The method comprises: receiving computer code of at least one application; determining, using a compartmentalization algorithm, at least one rule cache characteristic, and performance analysis information, compartmentalizations for the computer code and rules for enforcing the compartmentalizations; generating a compartmentalization security policy comprising the rules for enforcing the compartmentalizations; and instantiating, using a policy compiler, the compartmentalization security policy for enforcement in the tagged processor architecture, wherein instantiating the compartmentalization security policy includes tagging an image of the computer code of the at least one application based on the compartmentalization security policy. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/113254 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/577 (20130101) Original (OR) Class G06F 2221/033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281437 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald A. Davis (Las Cruces, New Mexico); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | A multiplicative analog frequency transform optical neural network (MAFT-ONN) encodes data in the frequency domain, achieves matrix-vector products in a single shot using photoelectric multiplication, and uses a single electro-optic modulator for the nonlinear activation of all neurons in each layer. Photoelectric multiplication between radio frequency (RF)-encoded optical frequency combs allows single-shot matrix-vector multiplication and nonlinear activation, leading to high throughput and ultra-low latency. This frequency-encoding scheme can be implemented with several neurons per hardware spatial mode and allows for an arbitrary number of layers to be cascaded in the analog domain. For example, a three-layer DNN can compute over four million fully analog operations and implement both a convolutional and fully connected layer. Additionally, a MAFT-ONN can perform analog DNN inference of temporal waveforms like voice or radio signals, achieving bandwidth-limited throughput, speed of light-limited latency, and fully analog complex-valued matrix operations. |
| FILED | Tuesday, January 03, 2023 |
| APPL NO | 18/149249 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/065 (20230101) G06N 3/0675 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281762 | Nasrabadi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Mogantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nasser M. Nasrabadi (Morgantown, West Virginia); Jeremy M. Dawson (Fairmont, West Virginia); Amol Joshi (Morgantown, West Virginia); Ali Dabouei (Morgantown, West Virginia) |
| ABSTRACT | Various examples are provided related to fingerphoto deblurring. In one example, a method includes generating, using a guided-attention (GA) mechanism, an intermediate feature map of a blurred image of a fingerprint and generating a deblurred image of the fingerprint based at least in part upon the intermediate feature map. The GA mechanism can generate the intermediate feature map by generating an attended feature map from an input feature map based upon a predicted attention map and adding the input feature map to the attended feature map. A system can include processing circuitry and a fingerphoto deblurring application that, when executed by the processing circuitry, causes the processing circuitry to generate the intermediate feature map and generate the deblurred image. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/112701 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4046 (20130101) G06T 5/003 (20130101) Original (OR) Class G06T 2207/20016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281770 | Dutson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Dutson (Madison, Wisconsin); Mohit Gupta (Madison, Wisconsin) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for generating digital images using low bit depth image sensor data are provided. In some embodiments, the system comprises: an image sensor; a processor programmed to: receive, from the image sensor, a series of low bit depth frames; provide low bit depth image information to a trained machine learning model comprising: a 3D convolutional layer; a 2D convolutional LSTM layer; a concatenation layer configured to generate a tensor that includes an output of the 2D convolutional LSTM layer and the low bit depth image information; and a 2D convolutional layer configured to generate an output based on the tensor; and generate a high bit depth image of a scene based on an output of the two-dimensional convolutional layer. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/687390 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/50 (20130101) Original (OR) Class G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/107 (20130101) Pictorial Communication, e.g Television H04N 9/646 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281970 | DORETTO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gianfranco DORETTO (Morgantown, West Virginia); Matthew Richardson KEATON (Morgantown, West Virginia) |
| ABSTRACT | System and methods for object segmentation include providing a pre-trained neural network model to segment object instances based on a first set of images and a first loss function. The neural network, for a pixel, can generate a gradient flow that points towards a center of an object structure and provides a probability score indicating a probability of the pixel belonging to the object structure. An adapted neural network model can be generated from the pre-trained neural network model to account for domain shifted new input images by training the pre-trained neural network model on a second set of images and a loss function that comprises a contrastive flow loss component and a contrastive mask loss component. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/118566 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30004 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/761 (20220101) G06V 10/774 (20220101) Original (OR) Class G06V 20/695 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282052 | REN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Jian REN (Okemos, Michigan); Ehab ZAGHLOUL (Chicago, Illinois); Tongtong LI (Okemos, Michigan) |
| ABSTRACT | A control system for conducting an election may include a voter client configured to be used by a voter to cast a vote for a candidate, a registrar server, and a moderator server. The moderator server may be configured to obscure the identity of the voter. The registrar server may be configured to randomly assign a ballot to the obscured voter. The registrar server may be configured to encrypt the ballot. The moderator server may be configured to transmit the encrypted ballot to the voter client. The voter client may be configured to decrypt the encrypted ballot to recover the ballot. The voter client, in response to the voter selecting a desired candidate, may be configured to generate a ballot associated with a vote. The voter client may be configured to encrypt the ballot using a public key of the registrar server and a public key of the moderator server. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 18/016981 |
| CURRENT CPC | Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 13/00 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/50 (20220501) H04L 9/0631 (20130101) H04L 9/0819 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282311 | Behsaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bahar Behsaz (Pasadena, California); Liu Cao (Pittsburgh, Pennsylvania); Mustafa Guler (Pittsburgh, Pennsylvania); Yi-Yuan Lee (Ithaca, New York); Hosein Mohimani (Pittsburgh, Pennsylvania); Mihir Mongia (Pittsburg, Pennsylvania); Donghui Yan (Pittburgh, Pennsylvania) |
| ABSTRACT | A method and system is for receiving data representing gene clusters, the gene clusters including one or more genes configured to encode one or more polypeptides or other small molecules; accessing a machine learning model, the machine learning model being trained with a training dataset that associates the gene clusters to structures of one or more small molecules represented in the data; applying the machine learning model to the data representing the gene clusters; identifying, based on applying the machine learning model, one or more monomers associated with at least one gene cluster represented in the data; and determining a structure for a natural product including the one or more monomers. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/076280 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282803 | Hosein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ian D. Hosein (Minoa, New York); Francielli Genier (Syracuse, New York); Shreyas Pathreeker (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | SYRACUSE UNIVERSITY (Syracuse, New York) |
| INVENTOR(S) | Ian D. Hosein (Minoa, New York); Francielli Genier (Syracuse, New York); Shreyas Pathreeker (Philadelphia, Pennsylvania) |
| ABSTRACT | A process for converting avocado peels into hard carbon-based anodes for sodium ion batteries and a hard carbon material formed according to that process. The avocado peels are simply washed and dried, and then carbonized using a high temperature conversion step. Electrochemical measurements confirmed the applicability of avocado-derived hard carbon as electrode active materials, with high reversible capacities of 320 mAh/g over 50 cycles at 50 mA/g, good rate performance of 86 mAh/g at 3500 mA/g, and Coulombic efficiencies above 99.9% after 500 cycles. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116267 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0471 (20130101) Original (OR) Class H01M 4/583 (20130101) H01M 10/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230282837 | Archer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lynden A. Archer (Ithaca, New York); Jingxu Zheng (Shenzen, China PRC); Jiefu Yin (Ithaca, New York) |
| ABSTRACT | In various examples, an anode, which may be for a metal ion-conducting electrochemical device, comprises a metal member; and a metal conducting coating, which may be an epitaxial (e.g., a homoepitaxial) metal conducing coating, disposed on at least a portion of the metal member (e.g., all portions of the metal member that would be or are in contact with the electrolyte of the metal ion-conducting electrochemical device). A metal conducting coating or an anode may be formed by electrodeposition in the presence of a field. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 18/008384 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 11/069 (20210101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/04 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/005 (20130101) C30B 7/12 (20130101) C30B 29/02 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/30 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0452 (20130101) H01M 4/626 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230283481 | Yavuz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Attila Altay Yavuz (Tampa, Florida) |
| ABSTRACT | A method for publicly verifiable symmetric cryptography is disclosed. The method includes: obtaining an initial encrypted key and a homomorphic public key; obtaining a first message and an initial signature; calculating an initial hashed value of the first message; setting a cryptographic function of the initial hashed value of the first message and an initial private key; generating an evaluated value based on the cryptographic function, the homomorphic public key, the initial encrypted key, and the initial hashed value of the first message; and transmitting, at the verifier, a verification result based on a hashed value of the initial signature and the evaluated value. Other aspects, embodiments, and features are also claimed and described. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178286 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/008 (20130101) H04L 9/0861 (20130101) H04L 9/0891 (20130101) H04L 9/3242 (20130101) H04L 9/3247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230277011 | Wesley |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randall Wesley (Chicago, Illinois) |
| ABSTRACT | An apparatus for showering within a bathtub having an upper rim and opposed ends spaced along a longitudinal axis is disclosed. The apparatus includes a frame, a bench coupled to the frame, and a pivotable platform assembly that is pivotably coupled to the frame. The pivotable platform assembly includes a platform and an engagement member that is coupled to the platform and extends downwardly from the platform to bias against an upper rim of the bathtub. The apparatus is configured for use within the bathtub in spaced relation, along the longitudinal axis of the bathtub, to each of the opposed ends of the bathtub. |
| FILED | Tuesday, May 09, 2023 |
| APPL NO | 18/314402 |
| CURRENT CPC | Chairs; Sofas; Beds A47C 7/14 (20130101) Sanitary Equipment Not Otherwise Provided for; Toilet Accessories A47K 3/122 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277543 | Kishore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bellamkonda Kishore (Salt Lake City, Utah); Noel Carlson (Salt Lake City, Utah) |
| ABSTRACT | Disclosed herein, are compositions comprising ticagrelor metabolites and methods of using the same to treat congestive heart failure, autosomal dominant polycystic kidney and liver diseases, cirrhosis of liver, cardiorenal syndrome, high altitude pulmonary hypertension, severe depression and autism. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/175630 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277586 | Barrett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Terrence Barrett (Lexington, Kentucky); Samuel Awuah (Lexington, Kentucky) |
| ABSTRACT | A method of increasing mitochondrial respiration in a cell makes use of a compound having the structure of formula (I) or formula (II). |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 18/006889 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/242 (20190101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277623 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong Feng Chen (Newtonville, Massachusetts); Chenying Guo (Malden, Massachusetts) |
| ABSTRACT | Disclosed is a method of promoting neuronal growth by administering IGFBPL-1, or an agent that increases or stabilizes IGFBPL-1 activity to a subject in need thereof, e.g., a subject in need of treating optic nerve degeneration. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/073951 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/352 (20130101) A61K 31/708 (20130101) A61K 31/711 (20130101) A61K 31/713 (20130101) A61K 31/7004 (20130101) A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 38/18 (20130101) Original (OR) Class A61K 38/22 (20130101) A61K 38/30 (20130101) A61K 38/1738 (20130101) A61K 38/1841 (20130101) A61K 38/2278 (20130101) A61K 45/06 (20130101) A61K 49/0056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230281346 | Aubin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Aubin (Seattle, Washington); Jeffrey Heckman (Seattle, Washington); George Eli Kaufman (Seattle, Washington); Daniel Abrahamson (Seattle, Washington); William Ledoux (Seattle, Washington); Beth Ripley (Seattle, Washington); Brittney Muir (Seattle, Washington); Jing-Sheng Li (Seattle, Washington); Chris Richburg (Seattle, Washington); Brian Strzelecki (Seattle, Washington) |
| ABSTRACT | Insoles and methods for making shoe insoles are disclosed An insole model can be generated based on a profile of a foot and a patient-specific pressure distribution. The profile of the foot can comprise a scan of a crush box impression. An insole can be formed from the insole model. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/179555 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/30 (20130101) Electric Digital Data Processing G06F 30/10 (20200101) Original (OR) Class G06F 2113/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230276762 | McFarland et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank McFarland (Toledo, Ohio); Heidi Kaeppler (Oregon, Wisconsin) |
| ABSTRACT | The present invention provides constructs comprising a WUSCHEL-like homeobox 2a (WOX2A) gene, methods of using these constructs to induce somatic embryogenesis in a plant tissue, and plants produced using these methods. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/179817 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/10 (20130101) Original (OR) Class A01H 6/4684 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230276802 | Swale et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State Universtiy and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State Universtiy and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Daniel R. Swale (High Springs, Florida); Lane D. Foil (Baton Rouge, Louisiana) |
| ABSTRACT | Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or elimination in the ability of the arthropod to feed. Administering Kir channel inhibitors reduces food intake, increases feeding time, reduces salivary gland secretion, induces mortality, and reduces transmission of vector-borne pathogens. Kir channel inhibitors induce these adverse effects in ticks, mosquitoes, horn flies, and aphids. |
| FILED | Thursday, April 20, 2023 |
| APPL NO | 18/136974 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/38 (20130101) A01N 43/40 (20130101) Original (OR) Class A01N 43/56 (20130101) A01N 43/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230277638 | PEREZ DE LEON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ADALBERTO A. PEREZ DE LEON (WAKE FOREST, North Carolina); ROBERT MILLER (MCALLEN, Texas); ROBERT E. BRIGGS (BOONE, Iowa); FRED M. TATUM (NEVADA, Iowa); FELICITO GUERRERO (KERRVILLE, Texas) |
| ABSTRACT | This invention relates to novel fusion peptides and immunogenic compositions containing the fusion peptides useful in the control and prevention of tick infestations. The invention also relates to compositions comprising said fusion peptides, methods of vaccination against tick infestation using said fusion peptides and compositions, and kits for use with such compositions and methods. |
| FILED | Wednesday, May 17, 2023 |
| APPL NO | 18/318909 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0003 (20130101) Original (OR) Class A61K 39/08 (20130101) A61K 2039/53 (20130101) A61K 2039/523 (20130101) A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/14 (20180101) Peptides C07K 14/33 (20130101) C07K 14/43527 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230277503 | Foster et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy Paul Foster (Slidell, Louisiana); Charles David Nichols (New Orleans, Louisiana) |
| ABSTRACT | This invention is directed to compositions, methods and kits for ameliorating or reducing pathogenesis of a disease by administering to a subject a serotonin receptor agonist. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/984011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/48 (20130101) A61K 31/137 (20130101) A61K 31/4045 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 31/22 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280417 | Gundlach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David James Gundlach (Montgomery Village, Maryland); Emily Geraldine Bittle (Bethesda, Maryland); Sebastian Engmann (Gaithersburg, Maryland) |
| ABSTRACT | A novel magnetic field sensor (MFS) may be created with an organic light emitting diode (OLED) made from an organic semiconductor material and an organic photodetector (OPD) built directly on top (or below) of the OLED, wherein one layer is made from a magnetically isotropic material, and which material has a magneto-resistive or magneto-electroluminescent signal that varies with the magnitude of a magnetic field to allow for measuring only the magnitude of the external magnetic field without regard to magnetic field direction. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116217 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/032 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280418 | Bittle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily Geraldine Bittle (Bethesda, Maryland); David James Gundlach (Montgomery Village, Maryland); Sebastian Engmann (Gaithersburg, Maryland) |
| ABSTRACT | A novel magnetic field sensor (MFS) may be created with an organic light emitting diode (OLED) made from an organic semiconductor material and an organic photodetector (OPD) built directly on top (or below) of the OLED, wherein at least one layer is made from an oriented molecular or polymer organic semiconductor material with strong magnetic anisotropy, and which material has a magneto-resistive or magneto-electroluminescent signal that varies with the magnitude and direction of a magnetic field to allow for measuring the vector of the external magnetic field. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116274 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/032 (20130101) Original (OR) Class Organic electric solid-state devices H10K 39/34 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230278728 | MAH |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as Represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Weber MAH (Cupertino, California) |
| ABSTRACT | A spacecraft capable of generating an artificial gravity environment comprises frame with a circular track with at least two modules traveling on the track. The two modules are configured to engage the first track opposite the first module to minimize mass imbalance, and a balancing system for the first and second modules configured to mass balance the first and second modules relative to each other. The frame itself does not rotate, and may have other mission supporting structures attached, including storage and supply modules, and observational modules, and spacecraft hangars and spacecraft docking modules. A method of operating a spacecraft to generate artificial gravity in a habitation module comprises operating a frame in space, propelling first and second habitation modules about the frame to generate artificial gravity environments in the modules, and mass balancing the first module relative to the second module to maintain balance of the spacecraft. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/653644 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/46 (20130101) Original (OR) Class B64G 1/60 (20130101) B64G 1/646 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230280487 | Meyer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steve Meyer (Tucson, Arizona) |
| ABSTRACT | An assembly for providing an active seismic source includes a motor and a drive shaft coupled to the motor. A crank is coupled to the drive shaft. The motor is configured to impart rotation of the crank in a first rotational direction. A one-way bearing permits rotation of the crank relative to the drive shaft in the first rotational direction and inhibits rotation of the crank relative to the drive shaft in an opposed second rotational direction. The assembly also includes a strike plate, a track, and a hammer that is movable along the track along an axis that extends toward and away from the strike plate. The hammer contacts the strike plate. A biasing element biases the hammer toward the strike plate. A linkage arm couples the hammer to the crank and translates rotational movement of the crank to linear movement of the hammer. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176774 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/62 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 1/09 (20130101) G01V 1/155 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230283136 | Cantemir et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Olivia Bruj (Cluj, Romania); Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Codrin Cantemir (Columbus, Ohio); Olivia Bruj (Cluj, Romania) |
| ABSTRACT | An example method of producing an electric machine is described herein. The method can include providing the electric machine. The electric machine can include a rotor and a stator, where the stator includes a magnetic core and a stator winding. Additionally, the magnetic core can include a plurality of teeth defining a plurality of slots between adjacent teeth. The stator winding can also include a first portion arranged inside a slot and a second portion arranged outside the slot. The method can further include optimizing, using a computing device, a geometry of the first portion of the stator winding, where the first portion of the stator winding in the provided electric machine has the optimized geometry. |
| FILED | Friday, April 21, 2023 |
| APPL NO | 18/137891 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/17 (20200101) G06F 2113/24 (20200101) Dynamo-electric Machines H02K 3/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20230281454 | Savvides et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marios Savvides (Pittsburgh, Pennsylvania); Dipan Kumar Pal (Pittsburgh, Pennsylvania) |
| ABSTRACT | During training of deep neural networks, a Copernican loss (LC) is designed to augment a primary loss function, for example, a standard Softmax loss, to explicitly minimize intra-class variation and simultaneously maximize inter-class variation. Copernican loss operates using the cosine distance and thereby affects angles leading to a cosine embedding, which removes the disconnect between training and testing. |
| FILED | Monday, April 10, 2023 |
| APPL NO | 18/132509 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20230280266 | Vanneste et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COLORADO SCHOOL OF MINES (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Johan Vanneste (Golden, Colorado); Alexander Schwiebert (Golden, Colorado); John Arthur Bush (Lakewood, Colorado) |
| ABSTRACT | Methods and systems are described herein for early detection of scaling during processing of liquid solutions. Particularly, the methods and systems described herein provide detection of the onset of scalant crystallization, so that measures can be deployed in a way that avoids significant scaling of membranes or other separating elements. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/180045 |
| CURRENT CPC | Separation B01D 61/12 (20130101) B01D 61/025 (20130101) B01D 65/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/01 (20130101) Original (OR) Class G01N 21/532 (20130101) G01N 2021/0106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, September 07, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230907.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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