FedInvent™ Patent Applications

Application Details for Thursday, September 14, 2023 

This page was updated on Friday, September 15, 2023 at 10:00 PM GMT

Department of Health and Human Services (HHS) 

US 20230284715 Jayaraman et al.
FUNDED BY
Department of Health and Human Services (HHS)
Centers for Disease Control and Prevention (CDC)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Sundaresan Jayaraman (Atlanta, Georgia);  Sungmee Park (Atlanta, Georgia)
ABSTRACT An exemplary apparatus and method are disclosed for a respiratory protective device. The respiratory protective device can be customized to the facial profile of a user and ensure proper fit and operation of device and attached breathable filter. In some embodiments, the device is configured to continuously monitor, via an integrated sensor embedded in the device's frame, the fit or proper particulate-filtering operation of the respiratory protective device. The sensor embodiment can ensure proper operation of respiratory protective device while providing monitoring and tracking of the fit to ensure personal safety for the healthcare professionals wearing the device.
FILED Tuesday, January 31, 2023
APPL NO 18/162315
CURRENT CPC
Outerwear; Protective Garments; Accessories
A41D 13/1107 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230284929 Srinivasan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S) Shriya Sruthi Srinivasan (Cambridge, Massachusetts);  Carlo Giovanni TRAVERSO (Newton, Massachusetts);  Robert S. LANGER (Newton, Massachusetts);  Amro A. Alshareef (Cambridge, Massachusetts)
ABSTRACT The gastrointestinal capsule provides mechanical stimulation within the gastrointestinal tract. The capsule may be deployed in a subject's gastrointestinal tract orally by the subject ingesting the capsule. The capsule may mechanically stimulate any desired region within the gastrointestinal tract, including the stomach, small intestine, and large intestine. The mechanical stimulations provided by the capsule are applied to a portion of the inner walls or lining of a section of the gastrointestinal tract to simulate satiety.
FILED Monday, March 13, 2023
APPL NO 18/182832
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/073 (20130101) Original (OR) Class

Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body
A61H 23/0254 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285143 Lederman et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) Robert J. Lederman (Chevy Chase, Maryland);  Toby Rogers (Washington, District of Columbia)
ABSTRACT Systems and methods of atrioventricular valve replacement are provided. In various embodiments, an arch-like support structure is provided that is insertable and implantable into a heart and is positioned in the mitral annulus to replace a native mitral valve. The support structure is operable to support, and various systems comprise leaflet and chord structures operable to control and regular blood flow between chambers of the heart.
FILED Tuesday, July 20, 2021
APPL NO 18/006331
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/2415 (20130101)
A61F 2/2418 (20130101) Original (OR) Class
A61F 2/2457 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285227 Srinivasan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S) Shriya Sruthi Srinivasan (Cambridge, Massachusetts);  Carlo Giovanni TRAVERSO (Newton, Massachusetts);  Robert S. LANGER (Newton, Massachusetts);  Amro A. Alshareef (Cambridge, Massachusetts)
ABSTRACT An ingestible capsule includes a housing forming a cavity and having a textured outer surface. The textured outer surface forms a helical depression and a plurality of protruding studs disposed in the helical depression. The capsule further includes a therapeutic agent disposed in or on the housing. The capsule also includes a biodegradable coating on the textured outer surface of the housing, the biodegradable coating configured to dissolve in a fluid having a pH of 1.5 to 9.
FILED Monday, March 13, 2023
APPL NO 18/182854
CURRENT CPC
Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body
A61H 23/0254 (20130101) Original (OR) Class
A61H 2201/105 (20130101)
A61H 2201/1692 (20130101)
A61H 2201/5005 (20130101)
A61H 2205/083 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 31/002 (20130101)
A61M 2205/10 (20130101)
A61M 2205/0238 (20130101)
A61M 2210/106 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285292 CHENG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Zhiliang CHENG (Newtown Square, Pennsylvania);  Ling Q. QIN (Moorestown, New Jersey);  Andrew B. TSOURKAS (Bryn Mawr, Pennsylvania);  Yulong WEI (Hubei, China PRC);  Beth A. WINKELSTEIN (Philadelphia, Pennsylvania);  Sonia KARTHA (Cambridge, Massachusetts)
ABSTRACT Provided herein are compositions comprising a drug delivery system comprising a phospholipid that is hydrolyzed by phospholipase A2 (PLA2) enzyme and a drug. Also provided herein are methods for treating or for determining the location of a region to be treated or monitored in a subject in need thereof, the methods comprising: administering to the subject the disclosed composition.
FILED Wednesday, June 23, 2021
APPL NO 18/002681
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/127 (20130101) Original (OR) Class
A61K 31/688 (20130101)
A61K 47/42 (20130101)
A61K 49/1809 (20130101)
A61K 49/1839 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 19/02 (20180101)
A61P 25/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285294 Sadabad et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Raana Kashfi Sadabad (Stanford, California);  Tulio A. Valdez (Stanford, California);  Anping Xia (Stanford, California)
ABSTRACT This application relates to various methods, agents, and systems for delivery of imaging and therapeutic agents to the middle and inner ear. On one aspect, there is a formulation provided in an ear drop form factor based on liposomal nanoparticles that penetrate the eardrum without an incision and can deliver therapeutic agents and/or contrast agents to the middle ear or therapeutic medications to the inner ear.
FILED Friday, April 07, 2023
APPL NO 18/132290
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/127 (20130101) Original (OR) Class

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285299 Elfar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) UNIVERSITY OF ROCHESTER (Rochester, New York)
ASSIGNEE(S) UNIVERSITY OF ROCHESTER (Rochester, New York)
INVENTOR(S) John Elfar (Rochester, New York);  Kuang-Ching Tseng (Rochester, New York);  Mark Noble (Brighton, New York)
ABSTRACT Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.
FILED Friday, April 14, 2023
APPL NO 18/300703
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0024 (20130101)
A61K 9/1647 (20130101) Original (OR) Class
A61K 9/7007 (20130101)
A61K 31/4409 (20130101)
A61K 45/06 (20130101)
A61K 47/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285305 Ma et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Peter X. Ma (Ann Arbor, Michigan);  Ming Dang (Maple Grove, Minnesota);  Laurie K. McCauley (Ann Arbor, Michigan)
ABSTRACT In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed.
FILED Saturday, May 20, 2023
APPL NO 18/199939
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0024 (20130101)
A61K 9/204 (20130101)
A61K 9/205 (20130101)
A61K 9/2031 (20130101) Original (OR) Class
A61K 9/5031 (20130101)
A61K 9/7007 (20130101)
A61K 38/29 (20130101)
A61K 47/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285322 MCGOWAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
NIH Office of the Director (NIHOD)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York);  Berg LLC (Framingham, Massachusetts);  The Research Foundation for Mental Hygiene, Inc. (Menands, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York);  Berg LLC (Framingham, Massachusetts);  The Research Foundation for Mental Hygiene, Inc. (Menands, New York)
INVENTOR(S) Josephine Cecelia MCGOWAN (New York, New York);  Christine Ann DENNY (Ho-Ho-Kus, New Jersey);  Michael KIEBISH (Framingham, Massachusetts)
ABSTRACT Biomarkers for assessing the efficacy of prophylactic treatments of stress-induced affective disorders are provided.
FILED Wednesday, September 28, 2022
APPL NO 17/954858
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/0043 (20130101)
A61K 9/0053 (20130101)
A61K 31/135 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/22 (20180101)
A61P 25/24 (20180101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 2800/30 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285328 Koeberl et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Duke University (Durham, North Carolina);  National University of Singapore (Singapore, Singapore)
ASSIGNEE(S) Duke University (Durham, North Carolina);  National University of Singapore (Singapore, Singapore)
INVENTOR(S) Dwight D. Koeberl (Durham, North Carolina);  Paul M. Yen (Singapore, Singapore);  Benjamin L. Farah (Rocky River, Ohio)
ABSTRACT The present disclosure is directed to methods of treating a steatosis-associated disorder by administering a therapeutic agent selected from a lysosomal enzyme, an autophagy-inducing agent, or a combination thereof. Steatosis-associated disorders discussed herein include GSD Ia, GSD Ib, GSD Ic, NAFLD, and NASH. Other embodiments are directed to methods of reversing steatosis, modulating autophagy, inducing autophagy, and reversing glycogen storage.
FILED Monday, May 22, 2023
APPL NO 18/200156
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/05 (20130101)
A61K 31/12 (20130101)
A61K 31/55 (20130101)
A61K 31/137 (20130101) Original (OR) Class
A61K 31/155 (20130101)
A61K 31/167 (20130101)
A61K 31/192 (20130101)
A61K 31/198 (20130101)
A61K 31/216 (20130101)
A61K 31/277 (20130101)
A61K 31/352 (20130101)
A61K 31/355 (20130101)
A61K 31/385 (20130101)
A61K 31/436 (20130101)
A61K 31/522 (20130101)
A61K 31/575 (20130101)
A61K 31/5415 (20130101)
A61K 31/7016 (20130101)
A61K 33/00 (20130101)
A61K 38/47 (20130101)
A61K 38/465 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/00 (20180101)

Enzymes
C12Y 301/04012 (20130101)
C12Y 302/0102 (20130101)
C12Y 302/01022 (20130101)
C12Y 302/01045 (20130101)
C12Y 302/01049 (20130101)
C12Y 302/01076 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285329 Koeberl et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Duke University (Durham, North Carolina);  National University of Singapore (Singapore, Singapore)
ASSIGNEE(S) Duke University (Durham, North Carolina);  National University of Singapore (Singapore, Singapore)
INVENTOR(S) Dwight D. Koeberl (Durham, North Carolina);  Paul M. Yen (Singapore, Singapore);  Benjamin L. Farah (Rocky River, Ohio)
ABSTRACT The present disclosure is directed to methods of treating a steatosis-associated disorder by administering a therapeutic agent selected from a lysosomal enzyme, an autophagy-inducing agent, or a combination thereof. Steatosis-associated disorders discussed herein include GSD Ia, GSD Ib, GSD Ic, NAFLD, and NASH. Other embodiments are directed to methods of reversing steatosis, modulating autophagy, inducing autophagy, and reversing glycogen storage.
FILED Monday, May 22, 2023
APPL NO 18/200557
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/05 (20130101)
A61K 31/12 (20130101)
A61K 31/55 (20130101)
A61K 31/137 (20130101) Original (OR) Class
A61K 31/155 (20130101)
A61K 31/167 (20130101)
A61K 31/192 (20130101)
A61K 31/198 (20130101)
A61K 31/216 (20130101)
A61K 31/277 (20130101)
A61K 31/352 (20130101)
A61K 31/355 (20130101)
A61K 31/385 (20130101)
A61K 31/436 (20130101)
A61K 31/522 (20130101)
A61K 31/575 (20130101)
A61K 31/5415 (20130101)
A61K 31/7016 (20130101)
A61K 33/00 (20130101)
A61K 38/47 (20130101)
A61K 38/465 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/00 (20180101)

Enzymes
C12Y 301/04012 (20130101)
C12Y 302/0102 (20130101)
C12Y 302/01022 (20130101)
C12Y 302/01045 (20130101)
C12Y 302/01049 (20130101)
C12Y 302/01076 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285331 MATHEW
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina)
ASSIGNEE(S)
INVENTOR(S) SAJISH MATHEW (LEXINGTON, South Carolina)
ABSTRACT Methods and compositions are described herein for modulating protein synthesis, especially monosome translation and DNA damage response, especially short-patch base excision repair (SP-BER), NHEJ and HR for treating a disorder. Compositions include a therapeutically effective amount of a tyrosine or a resveratrol derivative.
FILED Wednesday, November 23, 2022
APPL NO 17/993027
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/164 (20130101) Original (OR) Class
A61K 31/198 (20130101)
A61K 31/405 (20130101)
A61K 31/4164 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285338 Colonna et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Aging (NIA)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S) Marco Colonna (St. Louis, Missouri);  Tyler Ulland (St. Louis, Missouri)
ABSTRACT The present disclosure is directed to a method for treating a microglial dysfunction-associated neurodegenerative disease in a subject in need thereof. The method includes administering to the subject a therapeutically effective amount of a composition comprising a microglia receptor agonist that directly activates SYK.
FILED Tuesday, June 14, 2022
APPL NO 17/840368
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/195 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6827 (20130101)
C12Q 1/6883 (20130101)
C12Q 2600/156 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285346 Zhao
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Ann and Robert H. Lurie Children's Hospital of Chicago (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Youyang Zhao (Deerfield, Illinois)
ABSTRACT Disclosed are methods of treating pulmonary hypertension. More specifically, disclosed herein are methods of treating pulmonary hypertension by administering a therapeutically effective amount of an alpha-ketoglutarate-dependent dioxygenase FTO (FTO) inhibitor to a subject.
FILED Thursday, March 09, 2023
APPL NO 18/181231
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/47 (20130101)
A61K 31/205 (20130101) Original (OR) Class
A61K 31/4178 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/12 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285401 Zuo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Ting Therapeutics LLC (Omaha, Nebraska)
ASSIGNEE(S) Ting Therapeutics LLC (Omaha, Nebraska)
INVENTOR(S) Jian Zuo (Omaha, Nebraska);  Zhuo Li (Omaha, Nebraska);  Marisa Laura Zallocchi (Omaha, Nebraska)
ABSTRACT In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. Momelotinib and Fedratinib exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice when administered prophylactically. In one aspect, Momelotinib or Fedratinib can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED Monday, December 19, 2022
APPL NO 18/084033
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/506 (20130101)
A61K 31/5377 (20130101) Original (OR) Class
A61K 33/243 (20190101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285402 Markowitz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Dallas, Texas);  CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Sanford Markowitz (Pepper Pike, Ohio);  James K. V. Willson (Dallas, Texas);  Bruce Posner (Richardson, Texas);  Joseph Ready (Carrollton, Texas);  Monika Antczak (Ft. Worth, Texas);  Yongyou Zhang (Cleveland, Ohio);  Amar Desai (Cleveland, Ohio);  Stanton Gerson (Hunting Valley, Ohio);  William Greenlee (Cleveland, Ohio);  Sung Yeun Yang (Busan, South Korea);  KiBeom Bae (Busan, South Korea)
ABSTRACT Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
FILED Friday, March 03, 2023
APPL NO 18/117257
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/437 (20130101)
A61K 31/444 (20130101)
A61K 31/496 (20130101)
A61K 31/519 (20130101)
A61K 31/4365 (20130101)
A61K 31/5377 (20130101) Original (OR) Class

Heterocyclic Compounds
C07D 495/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285418 Zuo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Ting Therapeutics LLC (Omaha, Nebraska)
ASSIGNEE(S) Ting Therapeutics LLC (Omaha, Nebraska)
INVENTOR(S) Jian Zuo (Omaha, Nebraska);  Pezhman Salehi Dermanaki (Elkhorn, Nebraska);  Marisa Laura Zallocchi (Omaha, Nebraska);  Sarath Vijayakumar (Omaha, Nebraska)
ABSTRACT Acquired hearing loss due to chemotherapy or noise exposure is a major health problem, and Cisplatin chemotherapy often causes permanent hearing loss in cancer patients. However, there are no FDA-approved drugs for the treatment or prevention of Cisplatin- or noise-induced hearing loss. In one aspect, use of Niclosamide, Ingenol, and Elesclomol as an active agent to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED Thursday, December 15, 2022
APPL NO 18/081951
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/122 (20130101)
A61K 31/165 (20130101)
A61K 31/397 (20130101)
A61K 31/609 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285439 Clarke et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Chan Zuckerberg Biohub, Inc. (San Francisco, California);  The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Michael F. Clarke (Stanford, California);  Robert W. Hsieh (Stanford, California)
ABSTRACT The invention is directed to methods of treating TNBC in a patient by administering to the patient an agent that inhibits the expression or activity of cyclin-dependent kinase 19 (CDK19). In some embodiments, the agent may be a small molecule inhibitor, a polynucleotide (e.g., shRNA. siRNA), or a protein (e.g., an antibody). In some embodiments, the agent does not inhibit the activity or expression of CDK8.
FILED Monday, August 29, 2022
APPL NO 17/823028
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57415 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285446 Alverdy et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The University of Chicago (Chicago, Illinois);  UChicago Argonne, LLC (Chicago, Illinois)
ASSIGNEE(S) The University of Chicago (Chicago, Illinois);  UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S) John C. Alverdy (Glenview, Illinois);  Matthew Tirrell (Chicago, Illinois);  Olga Y. Zaborina (Brookfield, Illinois);  Jun Mao (Chicago, Illinois);  Wei Chen (Chicago, Illinois)
ABSTRACT The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.
FILED Wednesday, January 18, 2023
APPL NO 18/156058
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0095 (20130101)
A61K 31/77 (20130101) Original (OR) Class
A61K 31/80 (20130101)
A61K 31/765 (20130101)
A61K 47/10 (20130101)
A61K 47/34 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/00 (20180101)
A61P 31/04 (20180101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 65/3353 (20130101)
C08G 81/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285464 NGO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
ASSIGNEE(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
INVENTOR(S) John T. NGO (Cambridge, Massachusetts);  Jeffrey Blye MCMAHAN (Boston, Massachusetts)
ABSTRACT Described herein are polypeptides, systems, and methods that relate to using domains that bind specifically to a biotinylamide to control receptor and cellular activity.
FILED Friday, April 28, 2023
APPL NO 18/308899
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class

Peptides
C07K 14/705 (20130101)
C07K 14/7051 (20130101)
C07K 14/70521 (20130101)
C07K 16/28 (20130101)
C07K 16/44 (20130101)
C07K 16/2809 (20130101)
C07K 16/2818 (20130101)
C07K 2319/03 (20130101)
C07K 2319/30 (20130101)
C07K 2319/60 (20130101)
C07K 2319/71 (20130101)
C07K 2319/74 (20130101)
C07K 2319/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285499 Szeto et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Aging (NIA)
APPLICANT(S) Cornell University (Ithaca, New York);  University of Washington (Seattle, Washington)
ASSIGNEE(S) Cornell University (Ithaca, New York);  University of Washington (Seattle, Washington)
INVENTOR(S) Hazel H. Szeto (New York, New York);  Peter S. Rabinovitch (Shoreline, Washington);  Dao-Fu Dai (Seattle, Washington)
ABSTRACT The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.
FILED Monday, December 12, 2022
APPL NO 18/079604
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 38/07 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/00 (20180101)

Peptides
C07K 5/0817 (20130101)
C07K 5/1016 (20130101)
C07K 5/1019 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285500 Jurkunas
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) The Schepens Eye Research Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Ula V. Jurkunas (Winchester, Massachusetts)
ABSTRACT This application discloses compositions and methods for treating corneal endothelium disorders (e.g., Fuchs endothelial corneal dystrophy) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants using gene therapy.
FILED Tuesday, February 21, 2023
APPL NO 18/172062
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0048 (20130101)
A61K 31/00 (20130101)
A61K 31/26 (20130101)
A61K 31/385 (20130101)
A61K 38/07 (20130101) Original (OR) Class
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285501 Watnick
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
ASSIGNEE(S) CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
INVENTOR(S) Randolph S. Watnick (Newton, Massachusetts)
ABSTRACT Disclosed herein are polypeptides and fusion polypeptides that have anti-angiogenic activity that can be used to inhibit tumor growth and tumor metastasis. The polypeptide consists of 9 or less consecutive amino acid residues (e.g., 8, 7, 6, 5, or 4) comprising the active core amino acid sequence DWLP, or an amino acid substitution variant thereof. Specific amino acid substitutions are disclosed herein. In some embodiments, the peptide consists essentially of 4-6 mers identified as exhibiting the activity of prosaposin A. Also disclosed herein are therapeutic compositions comprising the polypeptides and fusion polypeptides, and their use in the treatment, prevention, and inhibition of angiogenesis-related diseases and disorders such as cancer and cancer metastasis.
FILED Tuesday, January 31, 2023
APPL NO 18/103740
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/07 (20130101)
A61K 38/08 (20130101) Original (OR) Class
A61K 39/39591 (20130101)
A61K 45/06 (20130101)
A61K 2039/505 (20130101)

Peptides
C07K 5/1019 (20130101)
C07K 5/1021 (20130101)
C07K 7/06 (20130101)
C07K 14/475 (20130101)
C07K 16/00 (20130101)
C07K 2319/30 (20130101)
C07K 2319/31 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/74 (20130101)
G01N 33/574 (20130101)
G01N 33/5023 (20130101)
G01N 33/6893 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285507 SPEES
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The University of Vermont and State Agriculture College (Burlington, Vermont)
ASSIGNEE(S) The University of Vermont and State Agriculture College (Burlington, Vermont)
INVENTOR(S) Jeffrey SPEES (Burlington, Vermont)
ABSTRACT The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
FILED Wednesday, January 25, 2023
APPL NO 18/159556
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/34 (20130101)
A61K 38/18 (20130101) Original (OR) Class
A61K 38/28 (20130101)
A61K 38/30 (20130101)

Peptides
C07K 14/65 (20130101)
C07K 14/475 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285512 Ardehali et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Reza Ardehali (Los Angeles, California);  Ngoc Nguyen (Los Angeles, California);  Peng Zhao (Los Angeles, California)
ABSTRACT Provided herein are methods and compositions related to treating and preventing an age-related disease and inhibiting cell death using thymosin proteins.
FILED Monday, March 14, 2022
APPL NO 17/693978
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 38/2292 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/10 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285526 Vujanovic et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S) Nikola L. Vujanovic (Pittsburgh, Pennsylvania);  Lazar Vujanovic (Pittsburgh, Pennsylvania)
ABSTRACT Methods are disclosed for inhibiting the development of a tumor in a subject. The methods include administering to a subject a therapeutically effective amount of a dominant negative tumor necrosis factor (DN-TNF)-α protein and/or a nucleic acid encoding the DN-TNF-α protein. The DN-TNF-α protein and/or a nucleic acid encoding the DN-TNF-α protein can be administered alone or in combination with other agents.
FILED Friday, March 10, 2023
APPL NO 18/182211
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/2013 (20130101)
A61K 38/2046 (20130101)
A61K 38/2086 (20130101)
A61K 39/00114 (20180801)
A61K 39/001117 (20180801) Original (OR) Class
A61K 39/001139 (20180801)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/525 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285536 Kaplan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Trustees of Tufts College (Medford, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) David Kaplan (Concord, Massachusetts);  Natalie Rubio (Medford, Massachusetts);  Andrew Stout (Cambridge, Massachusetts)
ABSTRACT The present invention provides animal cells that have been engineered to express one or more viral antigens. The engineered cells can be formulated into cultured meat products that can be used as edible vaccines.
FILED Thursday, June 24, 2021
APPL NO 18/002899
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/145 (20130101) Original (OR) Class
A61K 2039/5156 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/16 (20180101)

Peptides
C07K 14/11 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0601 (20130101)
C12N 5/0659 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285537 Heaton et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Nicholas Scott Heaton (Durham, North Carolina);  Alfred Theodore Harding (Durham, North Carolina);  Brook Elizabeth Heaton (Durham, North Carolina)
ABSTRACT Engineered Influenza polynucleotides, viruses, vaccines, and methods of making and using the same are provided. More specifically, the present inventors have developed replication competent engineered influenza viruses having, for example, a modified segment 4 and/or segment 6 that include at least one additional polynucleotide encoding a heterologous polypeptide.
FILED Monday, January 30, 2023
APPL NO 18/103343
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/39 (20130101)
A61K 39/145 (20130101) Original (OR) Class
A61K 2039/5252 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/16 (20180101)

Peptides
C07K 14/00 (20130101)
C07K 14/005 (20130101)
C07K 14/11 (20130101)
C07K 2319/42 (20130101)
C07K 2319/50 (20130101)
C07K 2319/60 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 9/2402 (20130101)
C12N 15/86 (20130101)
C12N 2760/16121 (20130101)
C12N 2760/16122 (20130101)
C12N 2760/16134 (20130101)
C12N 2760/16143 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285542 Gill et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Texas Tech University System (Lubbock, Texas)
ASSIGNEE(S)
INVENTOR(S) Harvinder Singh Gill (Lubbock, Texas);  Gaurav Joshi (Lubbock, Texas)
ABSTRACT The present invention includes and immunogenic composition and methods of immunizing a mammal or avian comprising: a nanoparticle conjugated to one or more antigenic peptides or fusion polypeptides from more than one strain of virus, wherein the one or more antigenic peptides or fusion polypeptides elicit at least one of a humoral, T helper cell-1 (Th1), T helper cell-2 (Th2) or cytotoxic T cell (CTL) immune response. In certain embodiments the antigenic peptides or fusion polypeptides are selected from at least one of SEQ IN NOS: 1 to 16, 22 to 39, or any combination thereof.
FILED Thursday, July 22, 2021
APPL NO 18/006097
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/39 (20130101)
A61K 39/125 (20130101)
A61K 39/145 (20130101)
A61K 39/155 (20130101)
A61K 39/215 (20130101) Original (OR) Class
A61K 39/235 (20130101)
A61K 2039/55572 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285557 NOLAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Human Genome Research Institute (NHGRI)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Garry P. NOLAN (Palo Alto, California);  John W. HICKEY (Palo Alto, California)
ABSTRACT The present disclosure relates generally to ex vivo expanded T cell populations suitable for use in adoptive immunotherapy. The disclosure also provides compositions and methods useful for preparing such ex vivo expanded T cell populations, as well as methods for the prevention and/or treatment of health conditions using the disclosed T cell populations.
FILED Thursday, July 08, 2021
APPL NO 18/004636
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/4611 (20230501) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
C12N 2501/999 (20130101)
C12N 2501/2302 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57484 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285559 Gu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
INVENTOR(S) Zhen Gu (Los Angeles, California);  Quanyin Hu (Los Angeles, California);  Hongjun Li (Los Angeles, California)
ABSTRACT A therapeutic hydrogel material is disclosed for the delivery of CAR-T cells that allows their distribution in the tumor resection recess, cavity, or void in combination with platelets decorated with the anti-programmed death-ligand 1 (PDL1) blocking antibody (aPDL1). The delivered hydrogel material acts as a reservoir for both CAR-T cells and platelet-bound aPDL1. Furthermore, inflammation occurring during the surgical wound healing triggers the release of platelet-derived microparticles containing the aPDL1. Cells delivered by the engineered hydrogel show significant control of local and distant tumor recurrence without causing toxic effects. In some embodiments, nanoparticles containing cytokines are also loaded in the therapeutic hydrogel material to maintain the activity and proliferation ability of CAR-T cells.
FILED Thursday, July 22, 2021
APPL NO 18/015709
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 38/2046 (20130101)
A61K 38/2086 (20130101)
A61K 39/4611 (20230501)
A61K 39/4631 (20230501) Original (OR) Class
A61K 47/36 (20130101)
A61K 47/6843 (20170801)
A61K 47/6901 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285568 PEARSON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S) University of Maryland, Baltimore (Baltimore, Maryland)
ASSIGNEE(S) University of Maryland, Balltimore County (Baltimore, Maryland)
INVENTOR(S) Ryan M. PEARSON (Baltimore, Maryland);  Gregory SZETO (Seattle, Washington);  Michael ZHANG (Baltimore, Maryland)
ABSTRACT Phospholipid-conjugated Ags were used as an agnostic delivery platform to cell type, activation state, and inherent uptake capabilities for engineering APCs to control Ag-specific cellular immune responses. Lipid-mediated delivery (termed depoting) of MHC class I and II-restricted Ags successfully loaded resting polyclonal B cells, CD40− activated B cells, and DCs in a dose-dependent manner for priming Ag-specific CD8+ and CD4+ T cells, respectively. When lipid-conjugated Ags were paired with polymer-conjugated Ags and incorporated in nanoparticles (NPs), diverse APCs with varying NP internalization capabilities all processed the lipid-conjugated Ags via depoting while only DCs processed the PLGA-conjugated Ags via endocytosis. Multivariate analyses of cytokine secretions indicated that lipid-conjugated Ags could be distinctly classified from polymer-conjugated Ags. Lipid and PLGA carriers can be rationally paired with Ag combinations to leverage two distinct delivery systems that access multiple Ag processing pathways in diverse APCs, offering a modular delivery platform for engineering ASITs.
FILED Thursday, August 05, 2021
APPL NO 18/040439
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/542 (20170801)
A61K 47/543 (20170801) Original (OR) Class
A61K 47/6929 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285591 LEE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California)
INVENTOR(S) Benhur LEE (New York, New York);  Karina PALOMARES (Los Angeles, California);  Olivier PERNET (Los Angeles, California)
ABSTRACT The present invention realtes to lentiviral particles which have been pseudotyped with Nipah virus (NiV) fusion (F) and attachment (G) glycoproteins (NiVpp-F/G). Additionally, the present invention relates to truncated NiV-F glyocproteins useful in producing such NiVpp lentiviral particles, as well as to additional variant peptides which enhance activity. Further, the present invention relates to methods of using such lentiviral particles or sequences, for example in the treatetment of cancer or CNS disorders.
FILED Friday, January 06, 2023
APPL NO 18/151174
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 48/00 (20130101)
A61K 48/0008 (20130101) Original (OR) Class
A61K 48/0075 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/86 (20130101)
C12N 2740/15021 (20130101)
C12N 2740/15032 (20130101)
C12N 2740/15041 (20130101)
C12N 2740/15043 (20130101)
C12N 2740/15071 (20130101)
C12N 2760/18222 (20130101)
C12N 2760/18232 (20130101)
C12N 2760/18234 (20130101)
C12N 2760/18241 (20130101)
C12N 2760/18245 (20130101)
C12N 2760/18271 (20130101)
C12N 2810/6027 (20130101)
C12N 2810/6072 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285603 Babich et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S) Cornell University (Ithaca, New York)
ASSIGNEE(S) Cornell University (Ithaca, New York)
INVENTOR(S) John W. Babich (New York, New York);  James M. Kelly (New York, New York);  Alejandro Amor-Coarasa (New York, New York);  Shashikanth Ponnala (New York, New York)
ABSTRACT The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer.
FILED Tuesday, October 11, 2022
APPL NO 17/963823
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 51/0402 (20130101)
A61K 51/0482 (20130101) Original (OR) Class
A61K 51/0497 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285636 Alsberg et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio);  WORCESTER POLYTECHNIC INSTITUTE (Worcester, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Eben Alsberg (Cleveland, Ohio);  Anna D. Dikina (Cleveland, Ohio);  Marsha W. Rolle (Worcester, Massachusetts)
ABSTRACT A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents.
FILED Tuesday, October 18, 2022
APPL NO 17/968476
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/54 (20130101)
A61L 27/3804 (20130101)
A61L 27/3882 (20130101) Original (OR) Class
A61L 2300/62 (20130101)
A61L 2300/414 (20130101)
A61L 2300/602 (20130101)
A61L 2400/12 (20130101)
A61L 2430/22 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0075 (20130101)
C12N 2513/00 (20130101)
C12N 2531/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285676 Koska et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) Koska Family Limited (East Sussex, United Kingdom)
ASSIGNEE(S)
INVENTOR(S) Marc Andrew Koska (Eastbourne, United Kingdom);  Max Hannon (Flemingate, United Kingdom);  Harris Ryder (Redruth, United Kingdom)
ABSTRACT A pre-filled medical delivery assembly can have a blow-fill-seal (BFS) module, a manifold, and a casing. The BFS module can have a pair of reservoirs, and a pair of sealed ports. Each reservoir can have a respective liquid agent therein. Each port can be in fluid communication with a respective one of the reservoirs. Part of the BFS module can be inserted into the manifold, and the casing can protect part of the BFS module exposed from the manifold. An orientation of the casing can be reversed, and the casing can be used to push the BFS module into the manifold to breach the seals and/or to compress the reservoirs to dispense the liquid agents. The disclosed assemblies can combine the liquid agents from the BFS module and deliver the combination as a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) to a patient.
FILED Monday, May 01, 2023
APPL NO 18/141559
CURRENT CPC
Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/284 (20130101)
A61M 5/2448 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285678 Sakhrani et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) Tribofilm Research, Inc. (Raleigh, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Vinay Sakhrani (Raleigh, North Carolina);  Jackson D. Thornton (Raleigh, North Carolina)
ABSTRACT The presently disclosed subject matter provides plasma-treated plastic syringe barrels with a plasma-treated lubricant coating and an interior surface with reduced number of particles as compared to an interior surface of a plastic syringe barrel with an untreated lubricant coating; plasma-treated plastic syringe barrels with a plasma-treated lubricant coating and an interior surface with extremely low surface density of particles; related syringes; related filled syringes with extremely low particle levels in solution; methods of treating the eye; methods of producing a plastic syringe barrel with a stable lubricant layer; related methods of producing a syringe; related syringes; and related methods of treating the eye.
FILED Tuesday, July 27, 2021
APPL NO 18/018483
CURRENT CPC
Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/3129 (20130101) Original (OR) Class
A61M 2005/3131 (20130101)
A61M 2205/0238 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285731 Falo et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S) Louis D. Falo (Wexford, Pennsylvania);  Geza Erdos (Wexford, Pennsylvania)
ABSTRACT A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components can be combined with other components to exhibit specific release kinetics when the microneedle array is inserted into the skin of a patient.
FILED Friday, April 28, 2023
APPL NO 18/141310
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0021 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 37/0015 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285747 Risi et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Cochlear Limited (Macquarie University, Australia);  University of Washington Center for Commercialization (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Frank Risi (Newtown, Australia);  Colin Irwin (Nice, France);  Jay T. Rubinstein (Seattle, Washington);  Felipe Santos (Boston, Massachusetts);  James O. Phillips (Seattle, Washington)
ABSTRACT A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures.
FILED Thursday, May 11, 2023
APPL NO 18/315679
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/361 (20130101)
A61N 1/0526 (20130101) Original (OR) Class
A61N 1/0551 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285755 Grill et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Warren Grill (Durham, North Carolina);  Nicole Pelot (Durham, North Carolina);  Minhaj Hussain (Durham, North Carolina)
ABSTRACT The present disclosure describes novel systems and methods to estimate the response of neurons to electrical stimulation and to determine the optimal electrode geometry and parameters of stimulation to activate or block specific targeted groups of neurons without activation or block of non-targeted groups of neurons.
FILED Friday, March 10, 2023
APPL NO 18/182018
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/36146 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/084 (20130101)
G06N 3/0442 (20230101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285784 Jayaraman et al.
FUNDED BY
Department of Health and Human Services (HHS)
Centers for Disease Control and Prevention (CDC)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Sundaresan Jayaraman (Atlanta, Georgia);  Sungmee Park (Atlanta, Georgia)
ABSTRACT An exemplary system and method are disclosed for a respiratory protective device configured to continuously monitor, via an integrated sensor network embedded in the device's frame, the fit or proper particulate-filtering operation of the respiratory protective device. The system can ensure proper operation of respiratory protective device while providing monitoring and tracking of the fit to ensure personal safety for users wearing the device. In some embodiments, the system can monitor, track, and aggregate the data to present via a user interface to the user.
FILED Tuesday, January 31, 2023
APPL NO 18/162312
CURRENT CPC
Devices, Apparatus or Methods for Life-saving
A62B 18/02 (20130101)
A62B 18/08 (20130101)
A62B 27/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285967 CRAIGHEAD et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S) CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S) Harold G. CRAIGHEAD (Ithaca, New York);  Sarah J. REINHOLT (Ithaca, New York)
ABSTRACT The present invention relates to, inter alia, a microfluidic device for capturing target cells and analyzing genomic DNA isolated from the target cells while under flow conditions. The microfluidic device includes a cell microchannel and a nucleic acid microchannel that intersect in an orthogonal manner, thereby forming a cell capture intersection region. The microfluidic device also includes a cell capture array and a nucleic acid entanglement array. The cell capture array includes a plurality of cell capturing micropillars and is located in the cell capture intersection region. The nucleic acid entanglement array includes a plurality of nucleic acid entanglement micropillars that function to physically entangle and maintain thereon genomic DNA isolated from the one or more target cell, and is located in a portion of the nucleic acid microchannel that is adjacent to and downstream of the cell capture intersection region. Methods of using the microfluidic device are also disclosed.
FILED Thursday, February 23, 2023
APPL NO 18/113553
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502753 (20130101) Original (OR) Class
B01L 3/502761 (20130101)
B01L 2200/0663 (20130101)
B01L 2200/0668 (20130101)
B01L 2300/0816 (20130101)
B01L 2300/0864 (20130101)
B01L 2400/086 (20130101)
B01L 2400/0487 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286920 Raines et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Ronald T. Raines (Cambridge, Massachusetts);  Brian Gold (Albuquerque, New Mexico);  Jesús M. Dones (Princeton, New Jersey);  Nile S. Abularrage (Boston, Massachusetts);  Brian James Graham (Belmont, Massachusetts)
ABSTRACT Provided herein are dibenzocyclooctyne compounds useful as reagents in 1,3-dipolar cycloaddition reactions, and methods for their preparation.
FILED Monday, May 01, 2023
APPL NO 18/309977
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 13/547 (20130101)
C07C 2603/36 (20170501)

Heterocyclic Compounds
C07D 221/16 (20130101) Original (OR) Class
C07D 231/54 (20130101)
C07D 249/16 (20130101)
C07D 471/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286922 MELANDER et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana)
ASSIGNEE(S) UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana)
INVENTOR(S) Christian MELANDER (South Bend, Indiana);  Veronica HUBBLE (South Bend, Indiana)
ABSTRACT We report improved adjuvant compounds that have an aryl 2-aminoimidazole structure for macrolide potentiation against a virulent strain of gram-negative bacteria, AB5075. Compounds were discovered to retain significant adjuvant activity at 10 μM, lowering the minimum inhibitory concentration (MIC) of clarithromycin (CLR) from 8-fold to 128-fold or greater. 2-Aminoimidazole compounds linked to aryl groups via either an amide or urea linker showed significantly improved activity over control compounds.
FILED Monday, April 19, 2021
APPL NO 18/000429
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4174 (20130101)
A61K 31/7048 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Heterocyclic Compounds
C07D 233/88 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286928 BEATON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Epigen Biosciences, Inc. (San Diego, California)
ASSIGNEE(S) Epigen Biosciences, Inc. (San Diego, California)
INVENTOR(S) Graham BEATON (San Diego, California);  Fabio C. TUCCI (San Diego, California);  Satheesh B. RAVULA (San Diego, California);  Chandravadan R. SHAH (San Diego, California);  Suk Joong LEE (San Diego, California)
ABSTRACT Heterocyclic compounds are described that are lysophosphatidic acid receptor ligands that are useful in the treatment of lysophosphatidic acid receptor-dependent diseases and conditions.
FILED Tuesday, June 18, 2019
APPL NO 18/015289
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/415 (20130101)

Heterocyclic Compounds
C07D 231/38 (20130101)
C07D 231/52 (20130101)
C07D 233/88 (20130101)
C07D 239/42 (20130101)
C07D 261/14 (20130101) Original (OR) Class
C07D 263/48 (20130101)
C07D 401/04 (20130101)
C07D 413/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286955 Cohen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Cornell University (Ithaca, New York);  Tri-Institutional Therapeutics Discovery Institute, Inc. (New York, New York)
ASSIGNEE(S)
INVENTOR(S) David E. Cohen (New York, New York);  Christopher Krumm (New York, New York);  John Ginn (New York, New York)
ABSTRACT The present disclosure relates to compounds that inhibit Them1. The disclosure further relates to methods of treating a metabolic disease in a subject in need thereof.
FILED Thursday, March 02, 2023
APPL NO 18/116625
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/16 (20180101)
A61P 3/10 (20180101)

Heterocyclic Compounds
C07D 403/06 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286982 Tepe et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of General Medical Sciences (NIGMS)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S)
INVENTOR(S) Jetze J. Tepe (East Lansing, Michigan);  Taylor J. Fiolek (DeWitt, Michigan);  Katarina Keel (Lansing, Michigan)
ABSTRACT Described herein are fluspirilene derivatives, methods for making such compounds, and the use of such compounds in the treatment of cancer, an inflammatory disease or condition or neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and ALS.
FILED Tuesday, August 10, 2021
APPL NO 18/041184
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/438 (20130101)

Heterocyclic Compounds
C07D 213/22 (20130101)
C07D 213/55 (20130101)
C07D 213/79 (20130101)
C07D 233/64 (20130101)
C07D 265/36 (20130101)
C07D 295/205 (20130101)
C07D 471/10 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286995 BANERJEE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
APPLICANT(S) UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Souvik BANERJEE (Fort Smith, Arkansas);  Shanshan DENG (Memphis, Tennessee);  Wei LI (Germantown, Tennessee);  K A Foyez MAHMUD (Chicago, Illinois);  Duane D. MILLER (Collierville, Tennessee);  Zhongzhi WU (Collierville, Tennessee);  Rui WANG (Memphis, Tennessee);  Tiffany SEAGROVES (Memphis, Tennessee);  Raisa KRUTILINA (Memphis, Tennessee);  Kelli HARTMANN (Memphis, Tennessee);  Satyanarayana POCHAMPALLY (Memphis, Tennessee)
ABSTRACT The invention encompasses novel dihydroquinoxalinone compounds with significantly improved water solubility and reduced toxicity to achieve higher therapeutic indexes and the treatment of cancer, virus infections, and inflammation using the same.
FILED Wednesday, April 20, 2022
APPL NO 17/725465
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 401/14 (20130101)
C07D 403/04 (20130101)
C07D 403/14 (20130101)
C07D 413/14 (20130101)
C07D 471/04 (20130101)
C07D 491/048 (20130101) Original (OR) Class
C07D 498/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287028 BISHOP et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (Brentford, United Kingdom);  FIMBRION THERAPEUTICS, INC. (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S) Michael Joseph BISHOP (Research Triangle Park, North Carolina);  Eugene L. Stewart (Collegeville, Pennsylvania);  Katherine Louisa Widdowson (San Diego, California);  James Walter Janetka (St. Louis, Missouri);  Laurel Kathryn McGrane (St. Louis, Missouri)
ABSTRACT Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
FILED Friday, April 28, 2023
APPL NO 18/308842
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0014 (20130101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 7/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287029 Hostetler et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Karl Y. Hostetler (La Jolla, California);  James Beadle (La Jolla, California);  Nadejda Valiaeva (La Jolla, California);  Robert T. Schooley (La Jolla, California)
ABSTRACT Compounds, including antiviral prodrugs, and pharmaceutical formulations including the compounds, which may be orally bioavailable or formulated for intramuscular injection. Methods for producing compounds, such as antiviral prodrugs. Methods for treating coronavirus and other RNA virus infection in mammals. Methods of producing a drug triphosphate.
FILED Saturday, July 24, 2021
APPL NO 18/006330
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 7/06 (20130101) Original (OR) Class
C07H 9/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287038 QI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) ACCESS TO ADVANCED HEALTH INSTITUTE (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Yizhi QI (Seattle, Washington);  Christopher Bradford FOX (Sumner, Washington)
ABSTRACT Substantially pure saponin extracts and orthogonal chromatographic methods for purification of saponin extracts are disclosed. The purified saponin extracts may include QS-21 and can have a purity of greater than 97%. The orthogonal chromatographic method uses reversed-phase (RP) chromatography followed by hydrophilic interaction liquid chromatography (HILIC) to generate substantially pure saponin extracts.
FILED Friday, June 04, 2021
APPL NO 18/020253
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/39 (20130101)
A61K 2039/55577 (20130101)

Separation
B01D 15/305 (20130101)
B01D 15/325 (20130101)

Steroids
C07J 63/008 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 30/72 (20130101)
G01N 30/8631 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287052 BESIRLI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) ONL Therapeutics, Inc. (Ann Arbor, Michigan);  The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Cagri G. BESIRLI (Ann Arbor, Michigan);  Alexander J. BRIDGES (Saline, Michigan);  John K. FRESHLEY (Ann Arbor, Michigan);  William A. HUNKE (Middletown, Delaware);  Linda L. JOHNSON (Ann Arbor, Michigan);  Francis X. SMITH (Salem, New Hampshire);  Ethan SYLVAIN (Manchester, New Hampshire);  David N. ZACKS (Ann Arbor, Michigan)
ABSTRACT Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas-or TRAIL-mediated apoptosis.
FILED Tuesday, January 24, 2023
APPL NO 18/159021
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/02 (20180101)

Peptides
C07K 7/08 (20130101) Original (OR) Class
C07K 14/71 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287055 Collins et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Department of Health and Human Ser. (Bethesda, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Ser. (Bethesda, Maryland)
INVENTOR(S) Peter Collins (Silver Spring, Maryland);  Bo Liang (Boyds, Maryland);  Shirin Munir (Potomac, Maryland);  Anne Schaap Nutt (Austin, Texas);  Ursula Buchholz (Silver Spring, Maryland);  Natalie Mackow (East Setauket, New York);  Peter Kwong (Washington, District of Columbia);  Barney Graham (Smyrna, Georgia);  Jason McLellan (Austin, Texas)
ABSTRACT Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
FILED Tuesday, January 31, 2023
APPL NO 18/162530
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/155 (20130101)
A61K 2039/5256 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 14/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287058 Bondy-Denomy et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Joseph Bondy-Denomy (Oakland, California);  Benjamin Rauch (Oakland, California)
ABSTRACT Cas9-inhibiting polypeptide compositions and methods are provided.
FILED Wednesday, September 28, 2022
APPL NO 17/954512
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/14 (20130101)
A61K 35/28 (20130101)

Peptides
C07K 14/195 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287059 Skaar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Eric P Skaar (Nashville, Tennessee);  Erin Green (Nashville, Tennessee)
ABSTRACT A composition, transgenic organism, and method of protecting against desiccation or heat are provided. The composition includes a DtpA protein or complement thereof and a heterologous biologic. The transgenic organism includes the nucleic acid sequence according to SEQ ID NO: 1. The method includes contacting a heterologous biologic or organism with a DtpA protein and/ or a complement thereof.
FILED Tuesday, July 20, 2021
APPL NO 18/006139
CURRENT CPC
Peptides
C07K 14/212 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
C12N 15/8201 (20130101)
C12N 2510/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287066 Llinas
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Manuel Llinas (State College, Pennsylvania)
ABSTRACT This document relates to sexual stage Plasmodium parasites. For example, Plasmodium parasites having (e.g., engineered to have) a regulatable AP2-G polypeptide that can be induced to enter the sexual stage are provided
FILED Friday, October 15, 2021
APPL NO 18/018230
CURRENT CPC
Peptides
C07K 14/445 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/10 (20130101)
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 15/902 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287067 Schlom et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Jeffrey Schlom (Potomac, Maryland);  Duane H. Hamilton (Washington, District of Columbia);  Claudia M. Palena (Potomac, Maryland);  Renee N. Donahue (Germantown, Maryland)
ABSTRACT The invention provides human immunogenic epitopes of HEMO and HHLA2 human endogenous retroviruses (HERVs), which can be used as a peptide, polypeptide (protein), and/or in a vaccine or other composition for the prevention or therapy of cancer. The invention further provides a nucleic acid encoding the peptide or polypeptide (protein), a vector comprising the nucleic acid, a cell comprising the peptide, polypeptide (protein), nucleic acid, or vector, and compositions thereof.
FILED Thursday, January 21, 2021
APPL NO 17/793753
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/127 (20130101)
A61K 35/17 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/47 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287090 WANG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Feinstein Institutes for Medical Research (Manhasset, New York)
ASSIGNEE(S)
INVENTOR(S) Haichao WANG (Edison, New Jersey);  Kevin J. TRACEY (Old Greenwich, Connecticut);  Jian Hua LI (New York, New York);  Cassie ZHU (Great Neck, New York);  Xiaoling QIANG (Hicksville, New York)
ABSTRACT Provided SARS-CoV-2 receptor binding motif (RBM)-reactive monoclonal antibodies and fragments thereof, which inhibit the interaction between the spike protein RBM and human ACE2, as well as methods of use employing such antibodies and/or fragments.
FILED Monday, August 30, 2021
APPL NO 18/019548
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 16/1018 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/92 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287140 Woods et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Elliot C. Woods (Burlingame, California);  Han Xiao (East Palo Alto, California);  Carolyn R. Bertozzi (Menlo Park, California);  Melissa Gray (Stanford, California)
ABSTRACT Provided are conjugates including a targeting moiety that binds to a cell surface molecule of a target cell and a target cell surface-editing enzyme. Also provided are compositions and kits that include the conjugates, as well as methods of using the conjugates. Methods of making conjugates are also provided.
FILED Friday, August 26, 2022
APPL NO 17/822638
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/32 (20130101) Original (OR) Class
C07K 19/00 (20130101)
C07K 2317/732 (20130101)
C07K 2319/33 (20130101)
C07K 2319/035 (20130101)
C07K 2319/74 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/2402 (20130101)

Enzymes
C12Y 302/01018 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287318 Pope et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Benjamin D. Pope (Medford, Massachusetts);  Kevin Kit Parker (Cambridge, Massachusetts)
ABSTRACT The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.
FILED Friday, March 03, 2023
APPL NO 18/116863
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/28 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 21/08 (20130101) Original (OR) Class
C12M 23/20 (20130101)
C12M 25/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0653 (20130101)
C12N 2533/30 (20130101)
C12N 2533/90 (20130101)
C12N 2535/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287357 SKYLAR-SCOTT et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Mark Andrew SKYLAR-SCOTT (Palo Alto, California);  Jennifer A. LEWIS (Cambridge, Massachusetts);  Jeremy Yuenchen HUANG (Cambridge, Massachusetts);  Jingcheng LU (Somerville, Massachusetts);  Tomoya DUENKI (Dachsen, Switzerland)
ABSTRACT Described herein are methods of generating a programmable multicellular organoid and/or a 3D organ-specific tissue. Also, described are the programmable multicellular organoid and/or a 3D organ-specific tissue produced by the described methods. Also, described herein are in vitro methods of generating functional human tissue construct.
FILED Tuesday, July 06, 2021
APPL NO 18/012064
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)

Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles
B29L 2031/7532 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 80/00 (20141201)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0697 (20130101) Original (OR) Class
C12N 15/85 (20130101)
C12N 15/635 (20130101)
C12N 2506/45 (20130101)
C12N 2513/00 (20130101)
C12N 2533/54 (20130101)
C12N 2533/56 (20130101)
C12N 2800/90 (20130101)
C12N 2800/107 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287362 Whiteley et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Aaron Whiteley (Boulder, Colorado);  Hannah Ledvina (Boulder, Colorado);  Kevin Corbett (San Diego, California);  Qiaozhen Ye (San Diego, California);  Yajie Gu (San Diego, California)
ABSTRACT The invention describes the discovery and novel application of a bacterial ubiquitin transferase (Cap2). Specifically, the invention describes the novel activity of the enzyme Cap2 which is capable of creating a specific fusion between two proteins implementing a standalone catalytic mechanism to create the fusion.
FILED Tuesday, March 14, 2023
APPL NO 18/183815
CURRENT CPC
Peptides
C07K 16/10 (20130101)
C07K 2319/30 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1007 (20130101)
C12N 9/1077 (20130101)
C12N 9/1241 (20130101) Original (OR) Class

Enzymes
C12Y 201/01 (20130101)
C12Y 204/02038 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287365 ROBSON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Simon C. ROBSON (Boston, Massachusetts);  Elizabeth H. ZHONG (Boston, Massachusetts)
ABSTRACT The present invention features bifunctional, soluble ecto-enzymes that are engineered to hydrolyze extracellular nucleotide triphosphates (e.g., ATP) to a nucleoside (e.g., adenosine), through the fusion of the ectodomains (ECD) of an ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) and a nucleotide monophosphatase (NMPAse), such as an ecto-5′ nucleotidase (eN), alkaline phosphatase (ALP), or an acid phosphatase (AP). Also described are methods of use thereof, e.g. for limiting and decreasing inflammation and sequelae.
FILED Friday, August 13, 2021
APPL NO 18/020342
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/46 (20130101)
A61K 38/465 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 29/00 (20180101)

Peptides
C07K 2319/30 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/14 (20130101) Original (OR) Class
C12N 9/16 (20130101)

Enzymes
C12Y 301/03005 (20130101)
C12Y 306/01005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287370 Zhang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Mental Health (NIMH)
APPLICANT(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Feng Zhang (Cambridge, Massachusetts);  Jonathan Leo Schmid-Burgk (Cambridge, Massachusetts);  Linyi Gao (Cambridge, Massachusetts);  David Li (Cambridge, Massachusetts)
ABSTRACT A method of identifying and characterizing novel Cas protein and guide RNAs with desired activity and specificity. The disclosure further comprises compositions and systems comprising engineered Cas protein and guide RNAs with desired activity and specificity.
FILED Thursday, March 11, 2021
APPL NO 17/910497
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101) Original (OR) Class
C12N 15/11 (20130101)
C12N 15/907 (20130101)
C12N 2310/20 (20170501)
C12N 2310/315 (20130101)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287371 MARRAFFINI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Rockefeller University (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Luciano MARRAFFINI (Brooklyn, New York);  Jakob ROSTOL (New York, New York)
ABSTRACT Provided is an isolated or recombinantly expressed protein comprising the sequence of SEQ ID NO: 1 (CARD1), or an amino acid sequence that is at least 90% identical to the sequence of CARD1. Methods for producing and isolating the CARD1 protein are provided. Also provided are methods that include using CARD1, Cas1O and RNA obtained from a biological sample, and a guide RNA targeted to an RNA polynucleotide that may be in the biological sample, and determining whether or not the CARD1 cleaves a reporter ssDNA or reporter ssRNA that is added to the sample, to determine the presence or absence of the RNA polynucleotide. Kits for use in the assay are also provided.
FILED Monday, July 19, 2021
APPL NO 18/006251
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101) Original (OR) Class
C12N 15/11 (20130101)
C12N 2310/20 (20170501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287373 ZHANG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts);  University of Tokyo (Tokyo, Japan)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts);  University of Tokyo (Tokyo, Japan)
INVENTOR(S) Feng ZHANG (Cambridge, Massachusetts);  Winston YAN (Cambridge, Massachusetts);  Osamu NUREKI (Tokyo, Japan);  Kaijie ZHENG (Cambridge, Massachusetts);  Le CONG (Cambridge, Massachusetts);  Hiroshi NISHIMASU (Tokyo, Japan);  Fei RAN (Cambridge, Massachusetts);  Yinqing LI (Cambridge, Massachusetts)
ABSTRACT The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRJSPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CR.ISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.
FILED Thursday, January 26, 2023
APPL NO 18/101867
CURRENT CPC
Peptides
C07K 2299/00 (20130101)
C07K 2319/09 (20130101)
C07K 2319/20 (20130101)
C07K 2319/70 (20130101)
C07K 2319/095 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101) Original (OR) Class
C12N 15/11 (20130101)
C12N 15/102 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 15/00 (20190201)
G16B 15/20 (20190201)
G16B 15/30 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287392 Robinson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) William H. Robinson (Palo Alto, California);  Yann Chong Tan (Palo Alto, California);  Jeremy Sokolove (Mountain View, California)
ABSTRACT Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herien are compositions and methods for expressing and screening molecules of interest.
FILED Tuesday, August 03, 2021
APPL NO 17/392848
CURRENT CPC
Peptides
C07K 16/00 (20130101)
C07K 16/1242 (20130101)
C07K 16/1271 (20130101)
C07K 2317/21 (20130101)
C07K 2317/76 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1065 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6854 (20130101)
G01N 2458/10 (20130101)
G01N 2500/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287397 Shoura et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California);  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Massa Shoura (Stanford, California);  Andrew Z. Fire (Stanford, California);  Stephen Levene (Richardson, Texas)
ABSTRACT Compositions and methods are provided for detection of dynamic loci in a genome. The methods may utilize microfluidic platforms and functionalized polymer matrices to allow determination of mechanisms of cell-type-specific, programmed genomic heterogeneity.
FILED Monday, April 10, 2023
APPL NO 18/298202
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1065 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287402 SASSON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Washington (Seattle, Washington);  MEDICAL RESEARCH COUNCIL, AS PART OF UNITED KINGDOM RESEARCH AND INNOVATION (Swindon, United Kingdom)
ASSIGNEE(S)
INVENTOR(S) Ariel Ben SASSON (Seattle, Washington);  David BAKER (Seattle, Washington);  William SHEFFLER (Seattle, Washington);  Hannele RUOHOLA-BAKER (Seattle, Washington);  Logeshwaran SOMASUNDARM (Seattle, Washington);  Emmanuel DERIVERY (Swindon, United Kingdom);  Joseph WATSON (Swindon, United Kingdom)
ABSTRACT The disclosure provides two-dimensional protein structures including first and second polypeptides that are different, each form homo-oligomers, and interact to form a rigid interface, polypeptide components of such two-dimensional protein structures, and uses thereof.
FILED Monday, August 23, 2021
APPL NO 18/040684
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/11 (20130101) Original (OR) Class
C12N 15/63 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287404 NAKAI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Oregon Health and Science University (Portland, Oregon)
ASSIGNEE(S)
INVENTOR(S) Hiroyuki NAKAI (Portland, Oregon);  Samuel HUANG (Portland, Oregon);  Kei ADACHI (Portland, Oregon)
ABSTRACT Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods.
FILED Friday, January 27, 2023
APPL NO 18/160796
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/11 (20130101) Original (OR) Class
C12N 15/86 (20130101)
C12N 2310/11 (20130101)
C12N 2320/33 (20130101)
C12N 2750/14123 (20130101)
C12N 2830/008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287405 NAKAI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Oregon Health and Science University (Portland, Oregon)
ASSIGNEE(S)
INVENTOR(S) Hiroyuki NAKAI (Portland, Oregon);  Samuel HUANG (Portland, Oregon);  Kei ADACHI (Portland, Oregon)
ABSTRACT Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods.
FILED Friday, January 27, 2023
APPL NO 18/160804
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/11 (20130101) Original (OR) Class
C12N 15/86 (20130101)
C12N 2310/11 (20130101)
C12N 2320/33 (20130101)
C12N 2750/14123 (20130101)
C12N 2830/008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287411 Fu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Xiang-Dong Fu (La Jolla, California);  Yuanchao Xue (La Jolla, California)
ABSTRACT The invention provides compositions and in vivo, ex vivo and in vitro methods for trans-differentiation of or re-programming mammalian cells to functional neurons. In particular, the invention provides methods for engineering non-neuronal cells into neurons, including fully functional human neuronal cells, and methods for engineering non-neuronal cells into neurons, e.g., fully functional human neuronal cells, in the brain to treat a neurodegenerative disease. In alternative embodiments, the invention provides compositions comprising re-differentiated or re-programmed mammalian cells, such as human cells, of the invention. The invention also provides compositions and methods for direct reprogramming of cells to a second phenotype or differentiated phenotype, such as a neuron, including a fully functional human neuronal cell. The invention also provides formulations, products of manufacture, implants, artificial organs or tissues, or kits, comprising a trans-differentiated or re-programmed cell of the invention, e.g., a fully functional human neuronal cell.
FILED Tuesday, October 04, 2022
APPL NO 17/938008
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101)
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0619 (20130101)
C12N 5/0623 (20130101)
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/531 (20130101)
C12N 2320/30 (20130101)
C12N 2501/15 (20130101)
C12N 2501/20 (20130101)
C12N 2501/24 (20130101)
C12N 2501/60 (20130101)
C12N 2501/998 (20130101)
C12N 2501/2318 (20130101)
C12N 2506/1307 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287427 Rosenzweig et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Aging (NIA)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Anthony Rosenzweig (Newton, Massachusetts);  Haobo Li (Allston, Massachusetts)
ABSTRACT The disclosure provides compositions comprising an inhibitory nucleic acid targeting IncExACTI, and methods of use thereof to improve cardiac function in a subject in need thereof. Specifically, the disclosure provides a cardiac long noncoding RNA (IncRNA), referred as IncExACT 1 (SEQ ID NO: 1), and inhibitory nucleic acids targeting IncExACT 1 for reducing expression of IncExACT 1 and/or Dachsous cadherin-related 2 (DCHS2) in a cell, e.g., a cell in a subject for improving cardiac function in a subject, wherein the subject has pathological cardiac hypertrophy and/or heart failure.
FILED Thursday, July 29, 2021
APPL NO 18/018478
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6929 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/04 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)
C12N 15/1136 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/531 (20130101)
C12N 2310/3515 (20130101)
C12N 2740/15043 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287438 Joshi et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) NORTHEASTERN UNIVERSITY (Boston, Massachusetts);  PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Neel S. Joshi (Somerville, Massachusetts);  IIia Gelfat (Cambridge, Massachusetts);  Anton KAN (Denton, Texas)
ABSTRACT Disclosed are methods for producing genetically modified bacteria, comprising introducing into said bacteria at least one engineered cryptic plasmid comprising a heterologous nucleic acid, wherein the heterologous nucleic acid comprises a nucleic acid sequence encoding a recombinant protein and a polypeptide secretion system for directing the recombinant protein to the outer membrane for secretion, wherein the bacteria do not comprise any native cryptic plasmids.
FILED Wednesday, September 15, 2021
APPL NO 18/026439
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0053 (20130101)
A61K 35/74 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
C12N 15/62 (20130101)
C12N 15/70 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287441 Abudayyeh et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Omar Abudayyeh (Cambridge, Massachusetts);  Jonathan Gootenberg (Cambridge, Massachusetts);  Lukas Villiger (Cambridge, Massachusetts);  Kaiyi Jiang (Cambridge, Massachusetts)
ABSTRACT This disclosure provides complexes for prime editing comprising an RNA-guided nuclease, a fusion protein comprising a reverse transcriptase domain linked to a nucleic acid binding protein, and a guide RNA (gRNA) comprising at least one protein-recruiting stem-loop nucleic acid sequence, wherein the protein-recruiting stem-loop nucleic acid sequence binds to the nucleic acid binding protein. Also provided are systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE) with integration enzymes paired with the prime editing complex.
FILED Friday, December 16, 2022
APPL NO 18/067214
CURRENT CPC
Peptides
C07K 14/005 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 9/1276 (20130101)
C12N 15/8213 (20130101) Original (OR) Class
C12N 2770/32322 (20130101)

Enzymes
C12Y 207/07049 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287444 Slade et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Arcadia Biosciences, Inc. (Davis, California)
ASSIGNEE(S)
INVENTOR(S) Ann J. Slade (Bellevue, Washington);  Dayna L. Loeffler (Seattle, Washington);  Aaron M. Holm (Shoreline, Washington);  Jessica C. Mullenberg (Lynnwood, Washington)
ABSTRACT A series of independent human-induced non-transgenic mutations found at one or more of the SBEII genes of wheat; wheat plants having these mutations in one or more of their SBEII genes; and a method of creating and finding similar and/or additional mutations of SBEII by screening pooled and/or individual wheat plants. The seeds and flour from the wheat plants of the present invention exhibit an increase in amylose and resistant starch without having the inclusion of foreign nucleic acids in their genomes. Additionally, the wheat plants of the present invention exhibit altered SBEII activity without having the inclusion of foreign nucleic acids in their genomes.
FILED Monday, April 10, 2023
APPL NO 18/298041
CURRENT CPC
New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques
A01H 6/4678 (20180501)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/107 (20130101)
C12N 15/8245 (20130101) Original (OR) Class

Enzymes
C12Y 204/01018 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287452 Vandenberghe et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Luk Vandenberghe (Weston, Massachusetts);  Guangping Gao (Westborough, Massachusetts);  James M. Wilson (Philadelphia, Pennsylvania)
ABSTRACT A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
FILED Friday, November 11, 2022
APPL NO 18/054786
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/00 (20130101)
A61K 48/005 (20130101)
A61K 48/0091 (20130101)

Peptides
C07K 14/005 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/86 (20130101) Original (OR) Class
C12N 2750/14122 (20130101)
C12N 2750/14142 (20130101)
C12N 2750/14143 (20130101)
C12N 2750/14152 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287457 Zhang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan);  CORNELL UNIVERSITY (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Yan Zhang (Ann Arbor, Michigan);  Ailong Ke (Ithaca, New York);  Ryan Krueger (Ann Arbor, Michigan);  Zhonggang Hou (Ann Arbor, Michigan)
ABSTRACT The disclosure provides a method of altering a DNA sequence, which method comprises the use of a type I-C CRISPR-Cas system based on Neisseria lactamica. The system involves a combination of two or more Neisseria lactamica proteins selected from Cas3, Cas5, Cas8c, and Cas7 and a synthetic guide RNA sequence.
FILED Wednesday, May 26, 2021
APPL NO 18/000676
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 15/70 (20130101)
C12N 15/907 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287459 Wiles et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) The Jackson Laboratory (Bar Harbor, Maine)
ASSIGNEE(S) The Jackson Laboratory (Bar Harbor, Maine)
INVENTOR(S) Michael V. Wiles (Bar Harbor, Maine);  Benjamin E. Low (Bar Harbor, Maine);  Vishnu Hosur (Bar Harbor, Maine)
ABSTRACT The present disclosure provides methods and compositions for high frequency, targeted mammalian transgenesis using, for example, a two-step, two-stage process that enables integrating anywhere in the mammalian genome large pieces of nucleic acid in single generation.
FILED Friday, August 06, 2021
APPL NO 18/019999
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0604 (20130101)
C12N 9/22 (20130101)
C12N 9/485 (20130101)
C12N 15/11 (20130101)
C12N 15/907 (20130101) Original (OR) Class
C12N 15/8509 (20130101)
C12N 2310/20 (20170501)
C12N 2510/00 (20130101)
C12N 2800/30 (20130101)
C12N 2800/80 (20130101)

Enzymes
C12Y 304/17023 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287473 Swami et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Asian Office of Aerospace Research and Development (AOARD)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)
INVENTOR(S) Nathan Swami (Charlottesville, Virginia);  Cirle Alcantrara Warren (Waynesboro, Virginia);  John Hudson Moore, II (Waynesboro, Virginia);  Carlos Honrado (Macedo Cavaleiros, Portugal);  Armita Salahi (Charlottesville, Virginia)
ABSTRACT A method for quantifying bacterial spore germination can include creating an ex vivo assay including bacteria spores and a homogenized stool sample. The ex vivo assay can be loaded into a microfluidic chip. Vegetative bacteria and the bacteria spores can be detected by sampling the mixture in the microfluidic chip using impedance cytometry to assess disruption of host microbiota.
FILED Wednesday, July 21, 2021
APPL NO 18/006236
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/04 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1031 (20130101)
G01N 2015/1006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287499 GONSKY et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Research Resources (NCRR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Cedars-Sinai Medical Center (Los Angeles, California)
ASSIGNEE(S)
INVENTOR(S) Rebecca GONSKY (Los Angeles, California);  Stephan R. TARGAN (Santa Monica, California)
ABSTRACT Described herein are methods, systems, compositions, and kits useful for identifying patients as having a high likelihood of recurrence of a disease or condition affecting the gastrointestinal tract following surgical treatment of the disease or condition. The present disclosure relates to methods and systems for identifying and stratifying patients, suitable for treatment with a modulator of RNASET2, as described herein.
FILED Wednesday, June 02, 2021
APPL NO 18/008150
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 2600/118 (20130101)
C12Q 2600/156 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287507 Jiang
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland);  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Feng Jiang (Ellicott City, Maryland)
ABSTRACT The present invention provides a method of predicting whether a pulmonary nodule in a subject is benign or non-small cell lung cancer, comprising obtaining the results of an assay that measures an expression level of miR205-5p in a plasma sample from the subject; obtaining the results of an assay that measures an expression level of miR126 in a plasma sample from the subject; obtaining the results of an assay that provides a size of the pulmonary nodule in the subject; and calculating a probability value based on the combination of the expression levels of miR205-5p and miR126, and the size of the pulmonary nodule, wherein if the probability value exceeds a specified threshold, the pulmonary nodule is predicted as non-small cell lung cancer.
FILED Tuesday, November 22, 2022
APPL NO 17/992668
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101)
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2525/207 (20130101)
C12Q 2561/113 (20130101)
C12Q 2600/178 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287510 WU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Catherine J. WU (Boston, Massachusetts);  Gad GETZ (Boston, Massachusetts);  Binyamin A. KNISBACHER (Cambridge, Massachusetts);  Ziao LIN (Cambridge, Massachusetts);  Cynthia K. HAHN (Boston, Massachusetts);  The Broad Institute, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts);  The General Hospital Corporation (Boston, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Catherine J. WU (Boston, Massachusetts);  Gad GETZ (Boston, Massachusetts);  Binyamin A. KNISBACHER (Cambridge, Massachusetts);  Ziao LIN (Cambridge, Massachusetts);  Cynthia K. HAHN (Boston, Massachusetts)
ABSTRACT As described below, the present invention features compositions, panels of biomarkers, and methods for characterizing chronic lymphocytic leukemia (CLL) for prognosis and selection of a subject for a treatment and/or inclusion in a clinical trial.
FILED Monday, August 09, 2021
APPL NO 18/020587
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6874 (20130101)
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/154 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288300 Rozhok et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) NanoCytomics, LLC (Evanston, Illinois);  Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Sergey Rozhok (Evanston, Illinois);  Justin R. Derbas (Evanston, Illinois);  Jarema Czarnecki (Evanston, Illinois);  Hariharan Subramanian (Evanston, Illinois)
ABSTRACT Automated cell staining systems and methods are disclosed herein. In particular, the staining systems disclosed herein provide low-volume, automated bench top staining systems for staining biological samples contained on a cytological slide.
FILED Monday, October 03, 2022
APPL NO 17/958718
CURRENT CPC
Apparatus for Applying Fluent Materials to Surfaces, in General
B05C 3/02 (20130101)
B05C 3/08 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/28 (20130101)
G01N 1/30 (20130101)
G01N 1/312 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288406 Lewis et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Nathan Lewis (La Jolla, California);  Wan-Tien Chiang (La Jolla, California);  Chenguang Liang (La Jolla, California);  James T. Sorrentino (La Jolla, California)
ABSTRACT A transformative method to profile the glycome in individual cells by leveraging computational biology tools with lectin or similar profiling technologies. Robust and accurate reconstruction glycomes with high-resolution glycan structure information for biological samples, including at the single cell level. Tools such as single-clone analysis andjoint-clone analysis, which may be used to assist researchers in analyzing single cell glycoprofiled samples, which identify how glycosylation variation across cells impact the cellular phenotypes. Single cell glycoprofiling using lectins is practically implemented to provide high resolution of the glycan structure information. Glycan profiling techniques having a wide range of biological applications from embryonic development to cancer and infectious disease due to high throughput, low cost, and robust reliability.
FILED Monday, August 02, 2021
APPL NO 18/007397
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5308 (20130101) Original (OR) Class
G01N 33/54326 (20130101)
G01N 2333/4724 (20130101)
G01N 2570/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288414 Casanova
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Human Genome Research Institute (NHGRI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE ROCKEFELLER UNIVERSITY (New York, New York);  NSERM(Institut National de la Santé la Recherche Médicale) (Paris, France);  Assistance Publique-Hôptiaux de Paris (APHP) (Paris, France);  Université Paris Cité (Paris, France);  Fondation Imagine (Paris, France)
ASSIGNEE(S)
INVENTOR(S) Jean-Laurent Casanova (New York, New York)
ABSTRACT The present invention provides methods, assays and kits for assessment of patients positive for SARS-CoV-2 infection and methods of diagnosis and treatment of COVID-19 disease and for assessment and evaluation of individuals prior to vaccination with live attenuated virus vaccines, particularly including yellow fever vaccines and COVID-19 vaccines, to assess risk for vaccine-associated disease and adverse events, and for evaluation, treatment and management of patients who develop vaccine-associated disease. The invention provides methods and assays for identification and characterization of inborn errors of type I interferon immunity and also auto-antibodies against Type I IFNs that are associated with severe COVID-19 disease or that are correlated and linked with vaccine-associated disease. The invention further provides methods of diagnosing and determining altered response to or susceptibility to SARS-CoV-2 infection or to live attenuated virus vaccines and for applicable and suitable treatment of COVID-19 disease or vaccine-associated disease.
FILED Thursday, July 22, 2021
APPL NO 18/017249
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/564 (20130101) Original (OR) Class
G01N 2333/555 (20130101)
G01N 2800/24 (20130101)
G01N 2800/50 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288424 Kislinger et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) University Health Network (Toronto, Canada);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Thomas Kislinger (Toronto, Canada);  Paul C. Boutros (Toronto, Canada);  Amanda Khoo (Toronto, Canada);  Yiyang Liu (Toronto, Canada)
ABSTRACT The present disclosure provides methods of prognosis of prostate cancer using mpMRl visibility biomarkers selected from SRD5A2, GNA11, CAPNS1, NCDN, WDR5 and/or LDHB.
FILED Friday, March 03, 2023
APPL NO 18/116963
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57434 (20130101) Original (OR) Class
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288435 Basmajian et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Baebies, Inc. (Durham, North Carolina)
ASSIGNEE(S) Baebies, Inc. (Durham, North Carolina)
INVENTOR(S) Michael A. Basmajian (Durham, North Carolina);  Michael Boso (Durham, North Carolina);  Jennifer Elderbroom (Durham, North Carolina)
ABSTRACT The invention relates generally to biochemical assays and more particularly to digital microfluidics multi-dynamic range parallel biochemical assays. The invention provides methods that enable improved precision and linearity for digital microfluidics analyses (i.e., analyses performed on a droplet actuator using droplet operations), including for example, assays related to measuring analytes in a biological sample. Examples of assays that may be performed using a method of the invention include measuring analytes in blood, including analytes from blood components, such as analytes present in plasma. The invention provides a digital microfluidics device (or cartridge) and methods for performing a biochemical assay using the microfluidics device to measure an analyte in a sample.
FILED Monday, October 10, 2022
APPL NO 17/962898
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502792 (20130101)
B01L 2400/0427 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/728 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288558 KONOFAGOU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Elisa E. KONOFAGOU (New York, New York);  Md Murad Hossain (New York, New York)
ABSTRACT The present subject matter relates to techniques for single transducer harmonic motion imaging. The disclosed system can include a transducer. The transducer can be configured to generate an amplitude-modulated acoustic radiation force (AM-ARF) by sinusoidally modulating a duration of an excitation pulse of an acoustic radiation force, induce a harmonic motion on a target tissue using the AM-ARF, and simultaneously track the harmonic motion by collecting a tracking pulse. The tracking pulse can be interleaved between the excitation pulse.
FILED Friday, December 09, 2022
APPL NO 18/064021
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 8/08 (20130101)

Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 7/629 (20130101)
G01S 7/52036 (20130101)
G01S 7/52095 (20130101)
G01S 15/102 (20130101)
G01S 15/8911 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288586 LI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
INVENTOR(S) Xin LI (, None);  Lars FURENLID (, None)
ABSTRACT The present invention provides a method of calibrating gamma-ray and photon counting detectors, including, but not limited to, monolithic crystal detectors. The method of the present invention is based on the observation that measurement of fan beam datasets allows the synthesis of collimated beam data to derive MDRFs by use of an algorithm that finds the common or intersecting data subsets of two or more orthogonal calibration datasets. This makes the calibration process very efficient while still allowing the full benefits of maximum-likelihood event-parameter estimation that incorporates the statistical nature of the light sensor measurements.
FILED Tuesday, December 20, 2022
APPL NO 18/068882
CURRENT CPC
Measurement of Nuclear or X-radiation
G01T 1/202 (20130101)
G01T 1/2018 (20130101)
G01T 1/2964 (20130101)
G01T 7/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230289972 Contijoch et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Francisco Contijoch (San Diego, California);  Zhennong Chen (San Diego, California);  Davis Vigneault (Palo Alto, California);  Marzia Rigolli (La Jolla, California)
ABSTRACT Devices, systems, and methods for automated segmentation and slicing of cardiac computed tomography (CT) images are described. An example method includes receiving a first plurality of input image frames associated with a cardiac CT operation, each of the first plurality of input image frames comprising a representation of two or more chambers of a heart, and performing, using a convolutional neural network, a segmentation operation and a slicing operation on each of the first plurality of input image frames to generate each of a plurality of output image frames comprising results of the segmentation operation and the slicing operation, wherein the segmentation operation comprises identifying volumes of each of the two or more chambers of the heart based on blood volumes, wherein the slicing operation comprises identifying one or more features of the heart in at least one predefined plane in a coordinate system associated with the cardiac CT operation.
FILED Tuesday, July 20, 2021
APPL NO 18/006145
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/11 (20170101) Original (OR) Class
G06T 7/0012 (20130101)
G06T 7/174 (20170101)
G06T 2207/10081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30048 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290433 Buckler et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Elucid Bioimaging Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Andrew J. Buckler (Boston, Massachusetts);  Ljubica Matic (Solna, Sweden);  Ulf Hedin (Ronninge, Sweden)
ABSTRACT Atherosclerotic plaque phenotyping by image data analysis, e.g., using conventional computed tomography angiography (CTA) or other imaging modalities can elucidate the molecular signature of atherosclerotic lesions on a per-patient basis.
FILED Friday, March 11, 2022
APPL NO 17/693229
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 5/20 (20190201) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290434 Castro et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Library of Medicine (NLM)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Egbert Castro (New Haven, Connecticut);  Smita Krishnaswamy (Madison, Connecticut);  Abhinav Godavarthi (Plano, Texas);  Julian Rubinfien (New York, New York)
ABSTRACT A system for identifying biomolecules with a desired property comprises a computer-readable medium with instructions stored thereon, which when executed by a processor perform steps comprising collecting a quantity of biomolecular data, transforming the biomolecular data from a sequence space to a latent space representation of the data, compressing the latent space representation using a pooling mechanism, compressing the coarse representation of the biomolecular data using an informational bottleneck, calculating a fitness factor of each data element in the low-dimensional representation of the biomolecular data, choosing a point from within the low-dimensional representation of the biomolecular data, calculating a set of gradients of the fitness factor, selecting an adjacent point having the highest gradient and setting it as the first point, then repeating the gradient calculating step until the fitness factor reaches a convergence point. A method for identifying biomolecules with a desired property is also disclosed.
FILED Friday, December 02, 2022
APPL NO 18/061272
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 15/20 (20190201) Original (OR) Class
G16B 40/20 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290467 NATARAJAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of General Medical Sciences (NIGMS)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland);  Yale University (New Haven, Connecticut);  The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland);  Yale University (New Haven, Connecticut);  The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S) Pradeep NATARAJAN (Boston, Massachusetts);  Giulio GENOVESE (Cambridge, Massachusetts);  Seyedeh Maryam ZEKAVAT (New Haven, Connecticut);  Mitchell J. MACHIELA (Bethesda, Maryland);  Shu-Hong LIN (Bethesda, Maryland)
ABSTRACT The invention features methods that are useful for treatment of a patient at increased risk for infection and for selecting a patient for treatment for an infection. In various embodiments, the infection is coronavirus disease 2019 (COVID-19), sepsis, or other respiratory infections.
FILED Tuesday, March 14, 2023
APPL NO 18/121496
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/20 (20190201)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/40 (20180101)
G16H 20/10 (20180101) Original (OR) Class
G16H 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20230284851 Krasnobaev
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Natick Soldier Systems Center (NSSC)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
APPLICANT(S) Vivonics, Inc. (Bedford, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Leonid Krasnobaev (Framingham, Massachusetts)
ABSTRACT A particle collection system and method including a collection inlet aimable at a surface from which particles are to be collected, and a rotatable fixture including at least a pair of nozzles about the collection inlet also aimable at the surface and fluidly connected to a source of compressed fluid in order to dislodge particles from the surface. The rotatable fixture is rotated to generate, as the nozzles rotate about the collection inlet, a vortex dislodging and picking up particles on the surface, entraining the particles, and carrying the particles to the collection inlet.
FILED Monday, February 27, 2023
APPL NO 18/174841
CURRENT CPC
Domestic Washing or Cleaning; Suction Cleaners in General
A47L 9/0416 (20130101)
A47L 9/1666 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230284939 Lin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Charles P. Lin (Arlington, Massachusetts);  Hari Prasad Paudel (Boston, Massachusetts)
ABSTRACT Systems, methods, and apparatus for differential phase contrast microscopy by transobjective differential epi-detection of forward scattered light are provided. In some embodiments, a microscope objective comprises: a housing with mounting threads at a second end; optical components defining an optical axis, comprising: an objective lens mounted at a first end, configured to collect light from a sample placed in a field of view, the plurality of optical components create a pupil plane at a first distance along the optical axis at which rays having the same angle of incidence on the objective lens converge at the same radial distance from the optical axis; a photodetector within the housing offset from the optical axis at a second distance along the optical axis; and another photodetector within the housing at second distance along the optical axis and offset from the optical axis in the opposite direction from the first photodetector.
FILED Wednesday, May 17, 2023
APPL NO 18/319163
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0068 (20130101)
A61B 5/1455 (20130101)
A61B 5/14535 (20130101) Original (OR) Class
A61B 2562/0233 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1436 (20130101)
G01N 15/1468 (20130101)
G01N 2015/144 (20130101)
G01N 2015/1006 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/002 (20130101)
G02B 21/008 (20130101)
G02B 21/14 (20130101)
G02B 21/0048 (20130101)
G02B 21/0056 (20130101)
G02B 21/0068 (20130101)
G02B 21/086 (20130101)
G02B 21/365 (20130101)
G02B 26/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285305 Ma et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Peter X. Ma (Ann Arbor, Michigan);  Ming Dang (Maple Grove, Minnesota);  Laurie K. McCauley (Ann Arbor, Michigan)
ABSTRACT In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed.
FILED Saturday, May 20, 2023
APPL NO 18/199939
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0024 (20130101)
A61K 9/204 (20130101)
A61K 9/205 (20130101)
A61K 9/2031 (20130101) Original (OR) Class
A61K 9/5031 (20130101)
A61K 9/7007 (20130101)
A61K 38/29 (20130101)
A61K 47/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285401 Zuo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Ting Therapeutics LLC (Omaha, Nebraska)
ASSIGNEE(S) Ting Therapeutics LLC (Omaha, Nebraska)
INVENTOR(S) Jian Zuo (Omaha, Nebraska);  Zhuo Li (Omaha, Nebraska);  Marisa Laura Zallocchi (Omaha, Nebraska)
ABSTRACT In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. Momelotinib and Fedratinib exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice when administered prophylactically. In one aspect, Momelotinib or Fedratinib can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED Monday, December 19, 2022
APPL NO 18/084033
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/506 (20130101)
A61K 31/5377 (20130101) Original (OR) Class
A61K 33/243 (20190101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285418 Zuo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Ting Therapeutics LLC (Omaha, Nebraska)
ASSIGNEE(S) Ting Therapeutics LLC (Omaha, Nebraska)
INVENTOR(S) Jian Zuo (Omaha, Nebraska);  Pezhman Salehi Dermanaki (Elkhorn, Nebraska);  Marisa Laura Zallocchi (Omaha, Nebraska);  Sarath Vijayakumar (Omaha, Nebraska)
ABSTRACT Acquired hearing loss due to chemotherapy or noise exposure is a major health problem, and Cisplatin chemotherapy often causes permanent hearing loss in cancer patients. However, there are no FDA-approved drugs for the treatment or prevention of Cisplatin- or noise-induced hearing loss. In one aspect, use of Niclosamide, Ingenol, and Elesclomol as an active agent to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED Thursday, December 15, 2022
APPL NO 18/081951
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/122 (20130101)
A61K 31/165 (20130101)
A61K 31/397 (20130101)
A61K 31/609 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285439 Clarke et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Chan Zuckerberg Biohub, Inc. (San Francisco, California);  The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Michael F. Clarke (Stanford, California);  Robert W. Hsieh (Stanford, California)
ABSTRACT The invention is directed to methods of treating TNBC in a patient by administering to the patient an agent that inhibits the expression or activity of cyclin-dependent kinase 19 (CDK19). In some embodiments, the agent may be a small molecule inhibitor, a polynucleotide (e.g., shRNA. siRNA), or a protein (e.g., an antibody). In some embodiments, the agent does not inhibit the activity or expression of CDK8.
FILED Monday, August 29, 2022
APPL NO 17/823028
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57415 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285539 JOYCE et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Uniformed Services University of the Health Sciences (USUHS)
Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
APPLICANT(S) The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland);  The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland)
ASSIGNEE(S) Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland);  The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland)
INVENTOR(S) Michael Gordon JOYCE (Silver Spring, Maryland);  Kayvon MODJARRAD (Bethesda, Maryland)
ABSTRACT The present disclosure relates to the field of vaccines and binding molecules, as well as preparations and methods of their use in the treatment and/or prevention of disease. Described are vaccines and binding molecules, compositions containing the same, and uses thereof for treating or preventing coronavirus infections, in particular, β-coronaviruses such as SARS- CoV-2, the causative agent of COVID-19, as well as SARS-CoV-1 and other coronaviruses.
FILED Monday, March 08, 2021
APPL NO 17/905614
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5169 (20130101)
A61K 39/215 (20130101) Original (OR) Class
A61K 2039/55505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285543 BOGDAN et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S) UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
INVENTOR(S) Paul BOGDAN (Los Angeles, California);  Shahin NAZARIAN (Los Angeles, California);  Zikun YANG (Los Angeles, California)
ABSTRACT Computer systems and computer implemented methods are presented for designing and making vaccines to pathogens, particular viral pathogens. Vaccine compositions for COVID-19 are also disclosed, as well as method of using the same.
FILED Wednesday, July 14, 2021
APPL NO 18/016230
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/215 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 15/20 (20190201)
G16B 15/30 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285930 Ramezani
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) ODH IP CORP. (New York, New York)
ASSIGNEE(S) ODH IP CORP. (New York, New York)
INVENTOR(S) Madhi Ramezani (Rockville, Maryland)
ABSTRACT Modular reactors comprising a chassis, reactor tubing and optionally a cover are disclosed. The chassis comprises a plurality of channels of different lengths into which a length of reactor tubing is placed to create the reactor portion of the flow reactor.
FILED Monday, March 20, 2023
APPL NO 18/186474
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/0073 (20130101)
B01J 19/0093 (20130101)
B01J 19/243 (20130101)
B01J 19/248 (20130101) Original (OR) Class
B01J 2219/00166 (20130101)
B01J 2219/00894 (20130101)
B01J 2219/00984 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286047 Mirkin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Chad A. Mirkin (Wilmette, Illinois);  Vinayak P. Dravid (Evanston, Illinois);  Liban Jibril (Evanston, Illinois)
ABSTRACT A method of forming a nanoparticle can include admixing an aqueous solution into an oil-phase to thereby form an emulsion of droplets of the aqueous solution in the oil phase, the aqueous solution comprising a nanostructure precursor and a polymer, adding a silane precursor and catalyst to form a silica shell around each of the droplets to nanoreactors; annealing at a first temperature below the decomposition temperature of the polymer to aggregate the nanostructure precursor within the nanoreactor; and annealing at a second temperature above the decomposition temperature of the polymer to convert the aggregated nanostructure precursor to the nanostructure and decompose the polymer.
FILED Monday, March 06, 2023
APPL NO 18/118031
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 1/16 (20220101)
B22F 1/054 (20220101)
B22F 9/26 (20130101) Original (OR) Class

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286102 HARDY et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Board of Trustees of Michigan State University (East Lansing, Michigan);  Fraunhofer USA (Plymouth, Michigan)
ASSIGNEE(S) Board of Trustees of Michigan State University (East Lansing, Michigan);  Fraunhofer USA (Plymouth, Michigan)
INVENTOR(S) Aaron HARDY (East Lansing, Michigan);  Timothy A. GROTJOHN (Okemos, Michigan);  Edward K. DROWN (Haslett, Michigan);  Michael BECKER (East Lansing, Michigan)
ABSTRACT A polishing apparatus is provided. Another aspect pertains to a self-leveling polishing apparatus for smoothing diamonds. Yet another aspect of the present system uses a ball and swivel joint in a diamond polishing machine. A further aspect employs a polishing apparatus including a diamond-holder, an elongated arm using gravity to apply downward polishing pressure of the diamond workpiece against a polishing wheel, and a sweeping transmission to cause the holder to radially move across the rotating polishing wheel.
FILED Wednesday, March 09, 2022
APPL NO 17/922728
CURRENT CPC
Machines, Devices, or Processes for Grinding or Polishing; Dressing or Conditioning of Abrading Surfaces; Feeding of Grinding, Polishing, or Lapping Agents
B24B 9/161 (20130101) Original (OR) Class
B24B 37/26 (20130101)
B24B 37/105 (20130101)
B24B 41/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286675 Ward et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Research Laboratory (NRL)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) Evan M. Ward (Alexandria, Virginia);  Bryan C. Brown (Silver Spring, Maryland);  David F. Chicka (Vienna, Virginia);  Nathaniel K. Ng (Washington, District of Columbia)
ABSTRACT Systems and methods are provided for high fidelity long-duration autonomous spacecraft navigation relative to a planet's surface and measuring the dynamics of the planet. For a planet like Earth, embodiments of the present disclosure can be used to estimate the unpredictable components of Earth's orientation with respect to the inertial frame. Embodiments of the present disclosure further enable autonomous landmark navigation by providing systems and methods for satellites to autonomously recognize landmarks, using, for example, multiple computer vision approaches to recognize multiple types of landmarks.
FILED Tuesday, March 07, 2023
APPL NO 18/118720
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/244 (20190501) Original (OR) Class
B64G 1/361 (20130101)
B64G 1/365 (20130101)
B64G 2001/247 (20130101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286677 DENHAM
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
The Aerospace Corporation (AEROSPACE)
Federally Funded Research and Development Center (FFRDC)
Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S) The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S) The Aerospace Corporation (El Segundo, California)
INVENTOR(S) Donald Wayne DENHAM (Redondo Beach, California)
ABSTRACT An autonomous compliance controlled generic mooring station includes a pair of mooring systems connected to each other. The pair of mooring systems includes a pair of mooring interfaces, allowing the pair of mooring systems to change between a mooring state and a release state. One of the pair of mooring interfaces includes an electropermanent magnet and the other one of the pair of mooring interfaces includes a ferromagnetic plate. The electropermanent magnet and the ferromagnetic plate are configured to connect the pair of mooring systems together.
FILED Monday, March 14, 2022
APPL NO 17/694579
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/646 (20130101) Original (OR) Class
B64G 1/1078 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286820 Renner et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Julie Renner (Cleveland, Ohio);  R. Mohan Sankaran (Cleveland, Ohio)
ABSTRACT A method of ammonia synthesis is described that includes contacting a nitrogen gas-containing plasma with an aqueous solution, thereby forming ammonia from the nitrogen gas and water. The nitrogen gas-containing plasma is present in an electrochemical cell. The electrochemical cell includes a container including an acidic liquid electrolyte. The electrochemical cell also includes a source of nitrogen gas, a metal electrode at least partially immersed in the electrolyte, a metal tube electrode spaced apart from a surface of the electrolyte by a predetermined spacing. The electrochemical cell is configured to provide a plasma spanning the predetermined space from the metal tube electrode to contact the surface of the electrolyte when power is applied to the metal tube electrode.
FILED Monday, May 22, 2023
APPL NO 18/321404
CURRENT CPC
Ammonia; Cyanogen; Compounds Thereof
C01C 1/0494 (20130101) Original (OR) Class

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 1/04 (20130101)
C25B 11/02 (20130101)
C25B 11/061 (20210101)
C25B 11/081 (20210101)
C25B 15/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286871 Villalobos et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) Guillermo R. Villalobos (Springfield, Virginia);  Rafael R. Gattass (Washington, District of Columbia);  Michael Hunt (Alexandria, Virginia);  Shyam S. Bayya (Ashburn, Virginia);  Bryan Sadowski (Falls Church, Virginia);  Robert Miklos (La Plata, Maryland);  Frederic H. Kung (Alexandria, Virginia);  Woohong Kim (Lorton, Virginia);  L. Brandon Shaw (Woodbridge, Virginia);  Jasbinder S. Sanghera (Ashburn, Virginia);  Antti Makinen (Alexandria, Virginia)
ABSTRACT Disclosed is a method of flash sintering a sample composed of ceramic particles by providing laser energy to change the electrical properties of the ceramic material. The processes and systems disclosed herein do not require large heating equipment like a furnace allowing for a portable system of repairing ceramic materials in the field.
FILED Thursday, March 23, 2023
APPL NO 18/125181
CURRENT CPC
Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 35/64 (20130101) Original (OR) Class
C04B 35/111 (20130101)
C04B 35/563 (20130101)
C04B 2235/608 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286964 Palmese et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Giuseppe Raffaello Palmese (Hainesport, New Jersey);  Mengwen Yu (Philadelphia, Pennsylvania);  John Joseph La Scala (Wilmington, Delaware)
ASSIGNEE(S) DREXEL UNIVERISTY (Philadelphia, Pennsylvania);  The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S) Giuseppe Raffaello Palmese (Hainesport, New Jersey);  Mengwen Yu (Philadelphia, Pennsylvania);  John Joseph La Scala (Wilmington, Delaware)
ABSTRACT A series of bio-based benzoxazine monomers were developed. These benzoxazine monomers are liquid at room temperature with good processability due to their low viscosities at or near room temperature and their relatively low polymerization temperatures. Cured materials made from these bio-based benzoxazines have excellent thermal and mechanical properties.
FILED Friday, July 23, 2021
APPL NO 18/005704
CURRENT CPC
Heterocyclic Compounds
C07D 413/06 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287065 Zhang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S) Fuzhong Zhang (St. Louis, Missouri);  Christopher H. Bowen (St. Louis, Missouri);  Bin Dai (St. Louis, Missouri)
ABSTRACT The present disclosure is directed to systems and methods for synthesizing a spidroin. In some embodiments, the methods comprise synthesizing a monomer in vivo in a heterologous host, the monomer comprising an N-terminus IntC domain and a C-terminus IntN domain, and post-translationally polymerizing the synthesized monomer via in vitro split-intein mediated polymerization.
FILED Thursday, April 27, 2023
APPL NO 18/308301
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 48/05 (20190201)

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2089/00 (20130101)
B29K 2995/0088 (20130101)

Peptides
C07K 14/43518 (20130101) Original (OR) Class
C07K 2319/21 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
C12N 15/70 (20130101)

Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons
D01D 1/02 (20130101)
D01D 5/06 (20130101)

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 4/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287067 Schlom et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Jeffrey Schlom (Potomac, Maryland);  Duane H. Hamilton (Washington, District of Columbia);  Claudia M. Palena (Potomac, Maryland);  Renee N. Donahue (Germantown, Maryland)
ABSTRACT The invention provides human immunogenic epitopes of HEMO and HHLA2 human endogenous retroviruses (HERVs), which can be used as a peptide, polypeptide (protein), and/or in a vaccine or other composition for the prevention or therapy of cancer. The invention further provides a nucleic acid encoding the peptide or polypeptide (protein), a vector comprising the nucleic acid, a cell comprising the peptide, polypeptide (protein), nucleic acid, or vector, and compositions thereof.
FILED Thursday, January 21, 2021
APPL NO 17/793753
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/127 (20130101)
A61K 35/17 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/47 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287388 FUNKNER et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) CureVac Manufacturing GmbH (Tübingen, Germany)
ASSIGNEE(S) CureVac Manufacturing GmbH (Tübingen, Germany)
INVENTOR(S) Andreas FUNKNER (Tübingen, Germany);  Stefanie DORNER (Tübingen, Germany);  Stefanie SEWING (Tübingen, Germany);  Johannes KAMM (Tübingen, Germany);  Norbert BROGHAMMER (Tübingen, Germany);  Thomas KETTERER (Gomaringen, Germany);  Thorsten MUTZKE (Reutlingen, Germany)
ABSTRACT The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
FILED Tuesday, May 16, 2023
APPL NO 18/198258
CURRENT CPC
Separation
B01D 61/145 (20130101)
B01D 71/12 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1017 (20130101) Original (OR) Class

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 19/34 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 30/02 (20130101)
G01N 2030/027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287466 Ding et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH (GAINESVILLE, Florida)
ASSIGNEE(S) UNIVERSITY OF FLORIDA RESEARCH (GAINESVILLE, Florida)
INVENTOR(S) Yousong Ding (Gainesville, Florida);  Ran Zuo (Gainesville, Florida)
ABSTRACT The disclosure relates, in some aspects, to compositions and methods useful for production of nitrated aromatic molecules. The disclosure is based, in part, on whole cell systems expressing artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes. In some aspects, the disclosure relates to methods of producing nitrated aromatic molecules in whole cell systems having artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes.
FILED Tuesday, January 10, 2023
APPL NO 18/152329
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0006 (20130101)
C12N 9/0042 (20130101)
C12N 9/0075 (20130101)
C12N 15/62 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 13/227 (20130101) Original (OR) Class

Enzymes
C12Y 101/9901 (20130101)
C12Y 106/02004 (20130101)
C12Y 114/13039 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287473 Swami et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Asian Office of Aerospace Research and Development (AOARD)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)
INVENTOR(S) Nathan Swami (Charlottesville, Virginia);  Cirle Alcantrara Warren (Waynesboro, Virginia);  John Hudson Moore, II (Waynesboro, Virginia);  Carlos Honrado (Macedo Cavaleiros, Portugal);  Armita Salahi (Charlottesville, Virginia)
ABSTRACT A method for quantifying bacterial spore germination can include creating an ex vivo assay including bacteria spores and a homogenized stool sample. The ex vivo assay can be loaded into a microfluidic chip. Vegetative bacteria and the bacteria spores can be detected by sampling the mixture in the microfluidic chip using impedance cytometry to assess disruption of host microbiota.
FILED Wednesday, July 21, 2021
APPL NO 18/006236
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/04 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1031 (20130101)
G01N 2015/1006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287487 Ricke et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Air Force Office of Scientific Research (AFOSR)
Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E)
MIT Lincoln Laboratory (MITLL)
Federally Funded Research and Development Center (FFRDC)
Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S) Massachusetts Institute of Technology. (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology. (Cambridge, Massachusetts)
INVENTOR(S) Darrell Orlyn Ricke (Winchester, Massachusetts);  James Harper (Jamaica Plain, Massachusetts);  Brian S. Helfer (Brookline, Massachusetts);  Joseph Isaacson (Latham, New York);  Adam M. Michaleas (Hudson, New Hampshire);  Martha S. Petrovick (Barre, Massachusetts);  Eric Schwoebel (Woburn, Massachusetts);  Anna Shcherbina (East Palo Alto, California);  Philip Fremont-Smith (Newmarket, New Hampshire);  James G Watkins (Sutton, Massachusetts);  Edward C. Wack (Waltham, Massachusetts)
ABSTRACT The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components. The methods of the disclosure do not require any prior knowledge of individual DNA profiles or contributors to the complex DNA mixtures. Moreover, the methods of the disclosure may use any SNP panel, including those panels already existing and those panels specifically designed to maximize performance characteristics of the methods described herein.
FILED Wednesday, February 01, 2023
APPL NO 18/104727
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6858 (20130101) Original (OR) Class
C12Q 1/6869 (20130101)
C12Q 1/6886 (20130101)
C12Q 2600/156 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/00 (20190201)
G16B 40/10 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287520 Larson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S) Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S) Marilynn A. Larson (Lincoln, Nebraska);  James C. Baldwin (Huber Heights, Ohio);  Michael P. Dempsey (Bowie, Maryland)
ABSTRACT A method of detecting a presence of Francisella tularensis (F. tularensis). The method includes amplifying a first nucleic acid from said specimen using a first plurality of primers, said first plurality of primers comprising SEQ ID NO 4 and SEQ ID NO 5. When the first nucleic acid is detected, then the presence of F. tularensis is determined.
FILED Monday, January 09, 2023
APPL NO 18/152127
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101) Original (OR) Class
C12Q 1/6806 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287557 Hu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Yimin Hu (Clarksville, Maryland);  Feng Niu (Arlington Heights, Illinois);  Wei Lu (Great Falls, Virginia)
ASSIGNEE(S)
INVENTOR(S) Yimin Hu (Clarksville, Maryland);  Feng Niu (Arlington Heights, Illinois);  Wei Lu (Great Falls, Virginia)
ABSTRACT This invention provides a process or fabrication method of forming broadband anti-reflective (AR) coating over the mid-IR fluoride fiber for high power laser applications in mid-IR wavelength range. The AR coating consists of multiple-pair Lithium fluoride (LiF) and Al2O3, and was deposited by electron beam physical vapor deposition with an iron assistant source at low temperature (<60° C.). A thin encapsulation layer of Al2O3 was applied over the AR coating by atomic layer deposition technology. The measurements show the coating has a reflectivity of <1-1.5% in the range of 1.5-5.5 μm. The laser induced damage threshold (LIDT) test shows the damage threshold is greater than 8.9 MW/cm2 with no sign of any damage on the coating exposed to atmosphere. The durability and environmental tests of the AR coating with PVD coated encapsulation layer show good humidity resistance in open air and no degradation of film quality and optical performance are observed.
FILED Thursday, March 10, 2022
APPL NO 17/691537
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/30 (20130101) Original (OR) Class
C23C 14/081 (20130101)
C23C 14/083 (20130101)
C23C 28/3455 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287836 Thorup et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Contracting Command (ACC)
Redstone Arsenal (REDSTONE)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Jessie Thorup (Malden, Massachusetts);  Christopher David King (Salem, Massachusetts)
ABSTRACT Control schemes for controlling a gas turbine engine in response to disturbances associated with a load mechanically coupled with the gas turbine engine are provided. In one aspect, a gas turbine engine mechanically coupled with a load has a controller that includes executable control logic. The control logic includes a feedforward module, an aggressive control module, and a power turbine governor module. By executing the modules, the controller seeks to maintain a constant power turbine speed stably and subtly in response to small disturbances associated with the load and aggressively in response to large disturbances associated with the load, as well as smooth transitions between the responses.
FILED Monday, February 07, 2022
APPL NO 17/665800
CURRENT CPC
Aeroplanes; Helicopters
B64C 27/12 (20130101)

Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants
F02C 9/40 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287847 Liu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Junhui Liu (Washington, District of Columbia);  Ephraim Gutmark (Cincinnati, Ohio);  Allan Aubert (Washington, District of Columbia)
ABSTRACT Methods and apparatuses for reducing engine noise provided. In one embodiment, an apparatus is provided that includes a plurality of seals and flaps that are interconnected and circumferentially arranged. Also included are a plurality of micro-vortex generator pairs respectively disposed in a circumferential manner on an interior surface of the seals. Each micro-vortex generator pair includes a first and second micro-vortex generator. In another embodiment, a method of generating a plurality of vortices in a nozzle section of a jet engine is provided. A plurality of micro-vortex generator pairs are provided on a plurality of seal surfaces of the nozzle section, respectively. The micro-vortex generator pairs are constructed to generate two vortices adjacent to an interior surface of the nozzle section and extending in a direction towards a nozzle exit. The interaction between the nozzle flow and the micro-vortex generator pairs greatly modify the shock cell structure within the nozzle section and the turbulence structure in the jet plume.
FILED Monday, May 01, 2023
APPL NO 18/141586
CURRENT CPC
Jet-propulsion Plants
F02K 1/827 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2240/127 (20130101)
F05D 2240/128 (20130101)
F05D 2260/96 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288173 Kisailus et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) David Kisailus (Riverside, California);  Wei Huang (Riverside, California)
ABSTRACT Described herein are composite materials that can include a stiff phase and a compliant phase where the stiff phase forms an interpenetrating network within the compliant phase, the interpenetrating network can be described as bi-continuous phase, such as a gyroid phase. Also described are methods of making these materials.
FILED Friday, July 16, 2021
APPL NO 18/016435
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 71/02 (20130101)

Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General
F41H 5/0492 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288200 EKHOLM
FUNDED BY
Department of Commerce (DOC)
National Oceanic and Atmospheric Administration (NOAA)
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Woods Hole Oceanographic Institution (Woods Hole, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Alexander K. EKHOLM (Falmouth, Massachusetts)
ABSTRACT A device and method of using same having an inertial measurement unit (IMU), a controller, an activator, and an absolute position sensor configured to measure fluid-body waves. The controller calculates its orientation in a relative frame using data obtained from the IMU and fixed-point arithmetic. The controller transforms the relative orientation information into absolute units using data obtained from the absolute sensor and fixed-point arithmetic, producing wave measurements. The controller may then select a subset of wave measurements for transmission via an optional communications mechanism to a remote user.
FILED Saturday, March 11, 2023
APPL NO 18/120365
CURRENT CPC
Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry
G01C 13/004 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288248 Huang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Yuping Huang (Norwood, New Jersey);  Yongmeng Sua (Fort Lee, New Jersey);  Patrick Rehain (Allendale, New Jersey);  Shenyu Zhu (Jersey City, New Jersey);  Daniel Tafone (Port Murray, New Jersey);  Jeevanandha Ramanathan (Jersey City, New Jersey)
ABSTRACT Approaches, apparatuses and methods for single photon sensitive, non-interferometric photonics vibrometry applications based on quantum parametric mode sorting, optical gating and single photon counting are disclosed. In one embodiment, a controller module includes a photon detection unit, a pulse generator unit, a time synchronization unit, a data acquisition and processing unit and a central controller unit. In the second embodiment, a probe module with beam raster scanning ability includes an optical transceiver unit based on a bidirectional monostatic coaxial arrangement using off-the-shelf optical components and an optical beam steering device.
FILED Tuesday, August 30, 2022
APPL NO 17/899493
CURRENT CPC
Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves
G01H 9/004 (20130101) Original (OR) Class

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/0071 (20130101)
H01S 3/1106 (20130101)
H01S 3/094026 (20130101)
H01S 3/094076 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288412 Kidwell
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) David A. Kidwell (Alexandria, Virginia)
ABSTRACT The present invention provides for an analysis system and method that determines the presence of an analyte by generating electrical voltage and current. The intensity of the current is proportional to the amount of analyte present.
FILED Wednesday, March 08, 2023
APPL NO 18/119276
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5438 (20130101)
G01N 33/54388 (20210801) Original (OR) Class
G01N 2033/0068 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288549 Wang et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Nanyang Technological University (Singapore, Singapore)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  Nanyang Technological University (Singapore, Singapore)
INVENTOR(S) Ziqi Wang (Los Angeles, California);  Mani Srivastava (Sherman Oaks, California);  Akash Deep Singh (Los Angeles, California);  Luis Garcia (Los Angeles, California);  Zhe Chen (Singapore, Singapore);  Jun Luo (Singapore, Singapore)
ABSTRACT Systems and methods for simultaneously recovering and separate sounds from multiple sources using Impulse Radio Ultra-Wideband (IR-UWB) signals are described. In one embodiment, a device can be configured for generating an audio signal based on audio source ranging using ultrawideband signals. In an embodiment the device includes, a transmitter circuitry, a receiver circuitry, memory and a processor. The processor configured to generate a radio signal. The radio signal including an ultra-wideband Gaussian pulse modulated on a radio-frequency carrier. The processor further configured to transmit the radio signal using the transmitter circuitry, receive one or more backscattered signals at the receiver circuitry, demodulate the one or more backscattered signals to generate one or more baseband signals, and generate a set of data frames based on the one or more baseband signals.
FILED Tuesday, November 15, 2022
APPL NO 18/055772
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 7/414 (20130101)
G01S 7/2813 (20130101)
G01S 7/2923 (20130101)
G01S 13/0209 (20130101) Original (OR) Class
G01S 13/888 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288637 Hermans et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Artur Hermans (Boston, Massachusetts);  Adrian Johannes Menssen (Cambridge, Massachusetts);  Christopher Louis Panuski (Somerville, Massachusetts);  Ian Robert Christen (Cambridge, Massachusetts);  Dirk Robert ENGLUND (Brookline, Massachusetts)
ABSTRACT An atom control architecture based on VIS-IR photonic integrated circuit (PIC) technology is characterized by (1) visible (VIS) and near-infrared (IR) wavelength operation, (2) channel counts extensible beyond 1000s of individually addressable atoms, (3) high intensity modulation extinction and (4) repeatability compatible with low gate errors, and (5) fast switching times. A 16-channel SiN-based APIC with (5.8±0.4) ns response times and <−30 dB extinction ratio at a wavelength of 780 nm. Based on a complementary metal-oxide-semiconductor (CMOS) fabrication process, this atom-control PIC (APIC) technology can be used for atomic, molecular, and optical physics and emerging applications, from quantum computers with cold atoms or ions to quantum networks with solid-state color centers. This APIC technology is especially suitable for scalable quantum information processing based on optically programmable atomic systems.
FILED Tuesday, January 10, 2023
APPL NO 18/152638
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/124 (20130101)
G02B 6/1225 (20130101) Original (OR) Class
G02B 6/12002 (20130101)
G02B 2006/12061 (20130101)
G02B 2006/12142 (20130101)

Computer Systems Based on Specific Computational Models
G06N 10/40 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288716 RUBIN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S) Noah A. RUBIN (Cambridge, Massachusetts);  Jan Philipp Balthasar MUELLER (Cambridge, Massachusetts);  Federico CAPASSO (Cambridge, Massachusetts)
ABSTRACT An optical component comprises a metasurface comprising nanoscale elements. The metasurface is configured to receive incident light and to generate optical outputs. The geometries and/or orientations of the nanoscale elements provide a first optical output upon receiving a polarized incident light with a first polarization, and provide a second optical output upon receiving a polarized incident light with a second polarization that is different from the first polarization.
FILED Monday, March 13, 2023
APPL NO 18/120958
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 1/002 (20130101)
G02B 5/3083 (20130101)
G02B 27/283 (20130101)
G02B 27/286 (20130101) Original (OR) Class
G02B 2207/101 (20130101)

Holographic Processes or Apparatus
G03H 1/0244 (20130101)
G03H 2222/31 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288773 Abdollahramezani et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Sajjad Abdollahramezani (Atlanta, Georgia);  Ali Adibi (Atlanta, Georgia);  Omid Hemmatyar (Atlanta, Georgia);  Hossein Taghinejad (Atlanta, Georgia)
ABSTRACT An exemplary embodiment of the present disclosure provides a reconfigurable hybrid metal-dielectric metasystem having a phase change material configured to reversibly transform between an amorphous state and a crystalline state upon a triggering event. The phase change material can be abutting a dielectric material on a first surface of the phase change material and a plasmonic material on an opposing second surface of the phase change material. An additional embodiment of the system includes when light travels through the system, the phase change material in the amorphous state can be configured to absorb a range of light, whereas the phase change material in the crystalline state can be configured to reflect the same range of light.
FILED Friday, July 30, 2021
APPL NO 18/005681
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/19 (20130101) Original (OR) Class
G02F 2201/50 (20130101)
G02F 2202/30 (20130101)
G02F 2203/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288774 Corato Zanarella et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Mateus Corato Zanarella (New York, New York);  Andres Gil Molina (New York, New York);  Xingchen Ji (New York, New York);  Min Chul Shin (New York, New York);  Aseema Mohanty (New York, New York);  Michal Lipson (New York, New York)
ABSTRACT Methods, systems, and devices for light emission are disclosed. An example device may comprise an optical source configured to output light, a waveguide optically coupled to the optical source and configured to carry the light, and a feedback portion configured to reflect the light back to the optical source via the waveguide. The feedback portion may comprise a microresonator optically coupled to the waveguide. The device may comprise one or more tuning elements configured to tune one or more of the microresonator or the waveguide to cause constructive interference between the reflected light and light of the optical source, resulting in optical emission of both the reflected light and the light of the optical source from an end of the waveguide.
FILED Thursday, November 03, 2022
APPL NO 18/052377
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/225 (20130101) Original (OR) Class
G02F 2201/06 (20130101)
G02F 2203/15 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230289557 OLSON et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S) Edwin OLSON (Ann Arbor, Michigan);  Dhanvin H. MEHTA (Ann Arbor, Michigan);  Gonzalo FERRER (Ann Arbor, Michigan)
ABSTRACT In Multi-Policy Decision-Making (MPDM), many computationally-expensive forward simulations are performed in order to predict the performance of a set of candidate policies. In risk-aware formulations of MPDM, only the worst outcomes affect the decision making process, and efficiently finding these influential outcomes becomes the core challenge. Recently, stochastic gradient optimization algorithms, using a heuristic function, were shown to be significantly superior to random sampling. In this disclosure, it was shown that accurate gradients can be computed—even through a complex forward simulation—using approaches similar to those in dep networks. The proposed approach finds influential outcomes more reliably, and is faster than earlier methods, allowing one to evaluate more policies while simultaneously eliminating the need to design an easily-differentiable heuristic function.
FILED Friday, May 12, 2023
APPL NO 18/196897
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/02 (20130101) Original (OR) Class
G06N 3/008 (20130101)
G06N 3/084 (20130101)
G06N 7/01 (20230101)

Pictorial Communication, e.g Television
H04N 1/00002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230289920 Bruder et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) University of Central Florida Research Foundation, Inc. (Orlando, Florida)
ASSIGNEE(S)
INVENTOR(S) Gerd Bruder (Orlando, Florida);  Gregory Welch (Orlando, Florida);  Kangsoo Kim (Orlando, Florida);  Zubin Choudhary (Orlando, Florida)
ABSTRACT One or more cameras capture objects at a higher resolution than the human eye can perceive. Objects are segmented from the background of the image and scaled to human perceptible size. The scaled-up objects are superimposed over the unscaled background. This is presented to a user via a display whereby the process selectively amplifies the size of the objects’ spatially registered retinal projection while maintaining a natural (unmodified) view in the remainder of the visual field.
FILED Wednesday, June 29, 2022
APPL NO 17/853072
CURRENT CPC
Image Data Processing or Generation, in General
G06T 3/40 (20130101) Original (OR) Class
G06T 7/73 (20170101)
G06T 7/194 (20170101)
G06T 19/006 (20130101)

Image or Video Recognition or Understanding
G06V 10/764 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290493 Redwood et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) William Owen Redwood (Omaha, Nebraska);  Jeff Dunn (Omaha, Nebraska);  Riley Hester (Omaha, Nebraska);  Ian Trent (Omaha, Nebraska);  Eric Wright (Omaha, Nebraska);  Brad Miller (Omaha, Nebraska);  Orly Tauil (Omaha, Nebraska)
ABSTRACT Methods and systems for medical device diagnostics and reporting. One system including an electronic processor configured to receive a new medical device dataset associated with a medical device. The electronic processor is also configured to determine an operation classification of the medical device using a model utilizing training information. The training information includes a plurality of archived medical device datasets and an associated operation classification for each of the plurality of archived medical device datasets. The electronic processor is also configured determine an operation status of the medical device based on the operation classification. The electronic processor is also configured to generate and provide a notification based on at least the operation status of the medical device.
FILED Thursday, June 24, 2021
APPL NO 18/007217
CURRENT CPC
Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 40/40 (20180101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230291167 Carey et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
APPLICANT(S) Phase Sensitive Innovations, Inc. (Newark, Delaware)
ASSIGNEE(S)
INVENTOR(S) Victoria Carey (Newark, Delaware);  Charles Harrity (Newark, Delaware);  Eliezer Shahid (Newark, Delaware);  Matthew Konkol (Newark, Delaware);  Christopher Schuetz (Avondale, Pennsylvania);  Peng Yao (Newark, Delaware);  Dennis Prather (Newark, Delaware)
ABSTRACT An RF pulse generator may comprise a pair of phase-locked lasers that output optical tones offset in frequency by a set amount. The resulting optical signal is periodically transmitted and blocked by an optical switch to generate a pulsed optical signal. A photodiode is irradiated with the pulsed optical signal to generate a corresponding pulsed RF signal having a frequency corresponding to the frequency difference of the optical tones generated by the phase-locked lasers. An antenna may be connected to and driven by the photodiode to electromagnetically transmit the pulsed RF signal.
FILED Monday, March 13, 2023
APPL NO 18/120985
CURRENT CPC
Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/0085 (20130101)
H01S 3/1112 (20130101) Original (OR) Class
H01S 3/06754 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230291419 Yoder
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Office of the Director of National Intelligence (ODNI)
Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) Theodore James Yoder (White Plains, New York)
ABSTRACT Techniques regarding quantum error correction are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a maximum-likelihood decoder component that executes a maximum-likelihood decoding algorithm to determine an error correction based on a decoding hypergraph that characterizes error-sensitive events associated with a quantum error-correcting code executed on a quantum circuit.
FILED Friday, March 11, 2022
APPL NO 17/654545
CURRENT CPC
Coding; Decoding; Code Conversion in General
H03M 13/01 (20130101)
H03M 13/09 (20130101)
H03M 13/1125 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230291467 GE et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
The Aerospace Corporation (AEROSPACE)
Federally Funded Research and Development Center (FFRDC)
Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S) The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S) The Aerospace Corporation (El Segundo, California)
INVENTOR(S) Howard H. GE (Hacienda Heights, California);  Erin Y. HONG (Lawndale, California);  Richard Y. CHIANG (Torrance, California);  Devon FEASTER (Torrance, California);  Tuong-Vi Thi TRAN (Garden Grove, California);  Michael ANDONIAN (Los Angeles, California)
ABSTRACT Embodiments of the present invention include a two-stage blending filter that blends the measurements from two angular sensors to form a single superior high bandwidth measurement for improved disturbance rejection in a satellite systems for increased accuracy in satellite pointing, orientation, and attitude control. Embodiments of the present invention can include a satellite system including a first sensor including or defining a first measurement bandwidth; a first filter connected to the first sensor; a second sensor including or defining a second measurement bandwidth; a second filter connected to the second sensor; and a third filter connected to the first filter and the second filter. The third filter blend the first signal and the second signal into a third signal; and transmit the third signal to a flight controller configured to adjust an orientation of the satellite, a satellite subsystem, or both, relative to a target in response to the third signal.
FILED Thursday, March 10, 2022
APPL NO 17/691696
CURRENT CPC
Transmission
H04B 1/1018 (20130101)
H04B 7/18539 (20130101) Original (OR) Class
H04B 7/18591 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230291541 Gupta et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
Division of Computer and Network Systems (CNS)
Office of Advanced Cyberinfrastructure (OAC)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Saransh Gupta (La Jolla, California);  Tajana Simunic Rosing (San Diego, California)
ABSTRACT A method of operating on encrypted data can be performed by receiving ciphertexts at a server that is configured to operate on the ciphertexts generated using a 3rd generation RGSW based fully homomorphic encryption system, operating on the ciphertexts received at the server in response to requested operations to generate respective input ciphertexts including ciphertext polynomials and ciphertext integers that are representative of the input ciphertexts, and processing the input ciphertexts in a server processing-in-memory device, that is operatively coupled to the server, to perform operations on the input ciphertext using the server processing-in-memory device, in-situ.
FILED Tuesday, January 10, 2023
APPL NO 18/152313
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/008 (20130101) Original (OR) Class
H04L 9/0825 (20130101)
H04L 9/3026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20230285543 BOGDAN et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S) UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
INVENTOR(S) Paul BOGDAN (Los Angeles, California);  Shahin NAZARIAN (Los Angeles, California);  Zikun YANG (Los Angeles, California)
ABSTRACT Computer systems and computer implemented methods are presented for designing and making vaccines to pathogens, particular viral pathogens. Vaccine compositions for COVID-19 are also disclosed, as well as method of using the same.
FILED Wednesday, July 14, 2021
APPL NO 18/016230
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/215 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 15/20 (20190201)
G16B 15/30 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285636 Alsberg et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio);  WORCESTER POLYTECHNIC INSTITUTE (Worcester, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Eben Alsberg (Cleveland, Ohio);  Anna D. Dikina (Cleveland, Ohio);  Marsha W. Rolle (Worcester, Massachusetts)
ABSTRACT A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents.
FILED Tuesday, October 18, 2022
APPL NO 17/968476
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/54 (20130101)
A61L 27/3804 (20130101)
A61L 27/3882 (20130101) Original (OR) Class
A61L 2300/62 (20130101)
A61L 2300/414 (20130101)
A61L 2300/602 (20130101)
A61L 2400/12 (20130101)
A61L 2430/22 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0075 (20130101)
C12N 2513/00 (20130101)
C12N 2531/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285910 Yang et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Research Foundation for the State University of New York (Albany, New York)
ASSIGNEE(S)
INVENTOR(S) Mengying Yang (Port Washington, New York);  Benjamin S. Hsiao (Setauket, New York)
ABSTRACT The present disclosure provides a nanostructured cellulose membrane system with high porosity, and methods for making same. The cellulose membrane system includes carboxylate-functionalized cellulose nanofibers combined with a cellulose microfiber scaffold, which are attached by a crosslinking reaction between the nanofibers and/or between the nanofibers and the microfiber scaffold.
FILED Monday, March 13, 2023
APPL NO 18/120470
CURRENT CPC
Separation
B01D 67/0002 (20130101)
B01D 67/00933 (20220801)
B01D 69/02 (20130101)
B01D 69/1214 (20220801)
B01D 71/10 (20130101) Original (OR) Class
B01D 2323/30 (20130101)
B01D 2323/081 (20220801)
B01D 2325/04 (20130101)
B01D 2325/20 (20130101)
B01D 2325/40 (20130101)
B01D 2325/0281 (20220801)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/24 (20130101)
B01J 20/3007 (20130101)
B01J 20/3085 (20130101)
B01J 20/28004 (20130101)
B01J 20/28035 (20130101)
B01J 20/28038 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/44 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285938 OLSEN et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Diatomix Inc. (Portland, Oregon)
ASSIGNEE(S)
INVENTOR(S) Joshua OLSEN (Portland, Oregon);  Nicholas DAY (Portland, Oregon);  Abigail PYEATT (Portland, Oregon)
ABSTRACT A composition comprising catalytic materials mixed with diatomaceous earth is provided, wherein, when the composition is exposed to irradiance, heat or other necessary activation environmental factors, the composition actively removes and degrades volatile organic compounds and/or metal ions from air or water streams. The composition can contain binding agents, rheology modifiers, and is shaped via compression or molding to be easily handled. Additionally, the composition can be used in forced-air or water streams to actively remove and degraded volatile organic compounds and/or metal ions from air or water streams.
FILED Friday, July 16, 2021
APPL NO 18/006023
CURRENT CPC
Separation
B01D 53/8687 (20130101)
B01D 2255/802 (20130101)
B01D 2255/20707 (20130101)
B01D 2257/93 (20130101)
B01D 2257/708 (20130101)
B01D 2258/06 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 21/08 (20130101) Original (OR) Class
B01J 21/063 (20130101)
B01J 35/004 (20130101)
B01J 35/023 (20130101)
B01J 35/026 (20130101)
B01J 37/04 (20130101)
B01J 37/08 (20130101)
B01J 37/0018 (20130101)

Reclamation of Contaminated Soil
B09C 1/08 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/30 (20130101)
C02F 1/725 (20130101)
C02F 2101/30 (20130101)
C02F 2305/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286015 Li et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Villanova University (Villanova, Pennsylvania)
ASSIGNEE(S) Villanova University (Villanova, Pennsylvania)
INVENTOR(S) Bo Li (Malvern, Pennsylvania);  Liang Zhao (Bryn Mawr, Pennsylvania)
ABSTRACT A method for forming a nanomaterial coating through solute-assisted assembly is provided. The method includes steps of: providing a mixture comprising a solvent, a solute, and a nanomaterial or particle; applying sonication to the mixture; and contacting a substrate with the mixture so as to form a coating of the nanomaterial or the particle onto the substrate. The solute is selected from a salt, a sugar, an acid, a base, or a combination thereof. The present disclosure also provides the resulting products comprising the nanomaterial coating for flexible electronics and functional textiles.
FILED Friday, November 18, 2022
APPL NO 17/989823
CURRENT CPC
Mixing, e.g Dissolving, Emulsifying, Dispersing
B01F 23/405 (20220101)
B01F 31/80 (20220101)

Processes for Applying Fluent Materials to Surfaces, in General
B05D 1/18 (20130101) Original (OR) Class
B05D 7/24 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 1/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286047 Mirkin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Chad A. Mirkin (Wilmette, Illinois);  Vinayak P. Dravid (Evanston, Illinois);  Liban Jibril (Evanston, Illinois)
ABSTRACT A method of forming a nanoparticle can include admixing an aqueous solution into an oil-phase to thereby form an emulsion of droplets of the aqueous solution in the oil phase, the aqueous solution comprising a nanostructure precursor and a polymer, adding a silane precursor and catalyst to form a silica shell around each of the droplets to nanoreactors; annealing at a first temperature below the decomposition temperature of the polymer to aggregate the nanostructure precursor within the nanoreactor; and annealing at a second temperature above the decomposition temperature of the polymer to convert the aggregated nanostructure precursor to the nanostructure and decompose the polymer.
FILED Monday, March 06, 2023
APPL NO 18/118031
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 1/16 (20220101)
B22F 1/054 (20220101)
B22F 9/26 (20130101) Original (OR) Class

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286177 Su et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Ohio State Innovation Foundation (Colmbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Haijun Su (Columbus, Ohio);  George Crowley (Columbus, Ohio);  Xianpai Zeng (Columbus, Ohio)
ABSTRACT A finger for a robotic gripper may include a flexible actuator, a flexible backbone, a rigid constraint frame, a plurality of jamming layers, and a jamming bag. The flexible actuator may have a proximal end, a distal end disposed opposite the proximal end, a first side, and a second side disposed opposite the first side. The flexible backbone may be coupled to the flexible actuator and disposed along the first side of the flexible actuator. The rigid constraint frame may be coupled to the flexible actuator and disposed along the second side of the flexible actuator. The jamming layers may be coupled to the flexible actuator and disposed at least partially within the rigid constraint frame. The jamming bag disposed at least partially within the rigid constraint frame and configured to apply a compressive force to the jamming layers when a positive pressure is generated within the jamming bag.
FILED Monday, February 27, 2023
APPL NO 18/114781
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 15/12 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286873 Cui et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) NUtech Ventures, Inc. (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Bai Cui (Lincoln, Nebraska);  Fei Wang (Lincoln, Nebraska);  Yongfeng Lu (Lincoln, Nebraska);  Michael Nastasi (Lincoln, Nebraska)
ABSTRACT Systems for and methods for improving mechanical properties of ceramic material are provided. The system comprises a heat source for heating the ceramic material to a temperature greater than a brittle-to-ductile transition temperature of the ceramic material; a probe for mounting the ceramic material and configured to extend the ceramic material into the heat source; a plasma-confining medium and a sacrificial layer disposed between the ceramic material and the plasma-confining medium; and an energy pulse generator such as a laser pulse generator. The sacrificial layer is utilized to form plasma between the ceramic material and the plasma-confining medium. The method comprises heating ceramic material to a temperature greater than a brittle-to-ductile transition temperature of the ceramic material and subjecting the ceramic material to energy pulses via a sacrificial layer and a plasma-confining medium whereby a plasma of the sacrificial coating forms between the ceramic material and a plasma-confining medium.
FILED Monday, May 01, 2023
APPL NO 18/310395
CURRENT CPC
Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam
B23K 26/53 (20151001)
B23K 26/083 (20130101)
B23K 26/356 (20151001)
B23K 26/0622 (20151001)

Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster
B28B 11/005 (20130101)

Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 35/10 (20130101)
C04B 41/0036 (20130101)
C04B 41/0072 (20130101) Original (OR) Class
C04B 41/4527 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287503 QUAKE et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
INVENTOR(S) Stephen QUAKE (Stanford, California);  Hei-Mun Christina FAN (Fremont, California)
ABSTRACT The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital analysis is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents.
FILED Wednesday, April 26, 2023
APPL NO 18/307093
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6809 (20130101)
C12Q 1/6851 (20130101)
C12Q 1/6858 (20130101)
C12Q 1/6881 (20130101)
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 2600/156 (20130101)
C12Q 2600/158 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 436/143333 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287585 Ozkan et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Umit Ozkan (Columbus, Ohio);  Seval Gunduz (Columbus, Ohio);  Dhruba Jyoti Deka (Columbus, Ohio)
ABSTRACT Disclosed herein are doped perovskite oxides. The doped perovskite oxides may be used as a cathode material in an electrochemical cell to electrochemically generate ammonia from N2. The doped perovskite oxides may be combined with nitride compounds, for instance iron nitride, to further increase the efficiency of the ammonia production.
FILED Wednesday, April 26, 2023
APPL NO 18/307289
CURRENT CPC
Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 49/009 (20130101)
C01G 51/70 (20130101)
C01G 53/70 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/34 (20130101)
C01P 2002/50 (20130101)
C01P 2006/40 (20130101)

Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 35/2633 (20130101)
C04B 35/2641 (20130101)
C04B 35/58042 (20130101)
C04B 2235/3274 (20130101)
C04B 2235/3852 (20130101)

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 1/00 (20130101)
C25B 1/27 (20210101)
C25B 9/19 (20210101)
C25B 9/23 (20210101)
C25B 11/047 (20210101)
C25B 11/051 (20210101)
C25B 11/069 (20210101) Original (OR) Class
C25B 11/0773 (20210101)
C25B 13/04 (20130101)
C25B 13/07 (20210101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287682 Blundo et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Tyler Blundo (Ringwood, New Jersey);  Christiana Honsberg (Tempe, Arizona);  Stephen Goodnick (Fort McDowell, Arizona);  Richard King (Tempe, Arizona);  Nicholas Irvin (Phoenix, Arizona)
ABSTRACT A skylight for a building includes a solar panel arranged within the skylight, the solar panel comprising one or more photovoltaic cells to collect direct radiation from rays of sunlight for conversion to electrical power, and an optical element to receive the direct radiation and refract it to the solar panel, and to receive the direct radiation and diffuse radiation scattered from the rays of sunlight and refract the direct radiation and the diffuse radiation through the skylight, bypassing the solar panel, to provide daylighting in the building.
FILED Friday, May 12, 2023
APPL NO 18/316943
CURRENT CPC
Roof Coverings; Sky-lights; Gutters; Roof-working Tools
E04D 13/033 (20130101) Original (OR) Class

Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates
E06B 9/24 (20130101)
E06B 2009/2417 (20130101)
E06B 2009/2494 (20130101)

Non-portable Lighting Devices; Systems Thereof; Vehicle Lighting Devices Specially Adapted for Vehicle Exteriors
F21S 11/002 (20130101)

Optical Elements, Systems, or Apparatus
G02B 5/32 (20130101)
G02B 5/208 (20130101)

Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules
H02S 20/26 (20141201)
H02S 40/22 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288239 Wang
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) University of South Carolina (Columbia, South Carolina)
ASSIGNEE(S) University of South Carolina (Columbia, South Carolina)
INVENTOR(S) Guiren Wang (Irmo, South Carolina)
ABSTRACT The present disclosure provides methods and systems for flight velocimetry employing at least one bleaching laser, at least one detection laser, at least one dichroic mirror, an objective, a detection system, and a nano stage to bleach a dye to form a bleached blot in a flow pathway.
FILED Thursday, May 18, 2023
APPL NO 18/319611
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0261 (20130101)
A61B 5/0285 (20130101)

Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume
G01F 1/206 (20130101)
G01F 1/661 (20130101)
G01F 1/7086 (20130101) Original (OR) Class

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/02 (20130101)
H01S 3/005 (20130101)
H01S 3/0007 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288354 Cianfrocco et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan);  INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Michael Cianfrocco (Ann Arbor, Michigan);  Quanfu Fan (Lexington, Massachusetts);  Yilai Li (Ann Arbor, Michigan);  Seychelle Vos (Cambridge, Massachusetts)
ABSTRACT Methods and systems for performing electron microscopy are provided. Microscopy images candidate sub-regions at different magnification levels are captured and provided to a trained sub-region quality assessment application trained to output a quality score for each candidate sub-region. From the quality scores, group-level features for the larger magnification images are determined using a group-level feature extraction application. The quality scores for the candidate sub-regions and the group-level extraction features are provided to a trained Q-learning network that identifies a next sub-region amongst the candidate sub-regions for capturing a micrograph image, where reinforcement learning may be used with the Q-learning network for such identification, for example using a decisional cost.
FILED Wednesday, March 08, 2023
APPL NO 18/119117
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 23/2251 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 7/97 (20170101)
G06T 2207/10061 (20130101)
G06T 2207/20084 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288477 Chakrabarty et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Krishnendu Chakrabarty (Durham, North Carolina);  Jonti Talukdar (Durham, North Carolina);  Arjun Chaudhuri (Durham, North Carolina)
ABSTRACT An integrated circuit (IC) protection circuit can include a reconfigurable block that receives a seed value from a tamper-proof memory and generates a dynamic key; an authentication block that receives the dynamic key from the reconfigurable block and taint bits from a scan chain to generate an authentication signature; and an encryptor that encrypts a test pattern response on the scan chain if a mismatch is found between the authentication signature and a test pattern embedded signature.
FILED Monday, March 14, 2022
APPL NO 17/693942
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/3177 (20130101) Original (OR) Class
G01R 31/31703 (20130101)

Electric Digital Data Processing
G06F 11/263 (20130101)
G06F 2201/83 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288549 Wang et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Nanyang Technological University (Singapore, Singapore)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  Nanyang Technological University (Singapore, Singapore)
INVENTOR(S) Ziqi Wang (Los Angeles, California);  Mani Srivastava (Sherman Oaks, California);  Akash Deep Singh (Los Angeles, California);  Luis Garcia (Los Angeles, California);  Zhe Chen (Singapore, Singapore);  Jun Luo (Singapore, Singapore)
ABSTRACT Systems and methods for simultaneously recovering and separate sounds from multiple sources using Impulse Radio Ultra-Wideband (IR-UWB) signals are described. In one embodiment, a device can be configured for generating an audio signal based on audio source ranging using ultrawideband signals. In an embodiment the device includes, a transmitter circuitry, a receiver circuitry, memory and a processor. The processor configured to generate a radio signal. The radio signal including an ultra-wideband Gaussian pulse modulated on a radio-frequency carrier. The processor further configured to transmit the radio signal using the transmitter circuitry, receive one or more backscattered signals at the receiver circuitry, demodulate the one or more backscattered signals to generate one or more baseband signals, and generate a set of data frames based on the one or more baseband signals.
FILED Tuesday, November 15, 2022
APPL NO 18/055772
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 7/414 (20130101)
G01S 7/2813 (20130101)
G01S 7/2923 (20130101)
G01S 13/0209 (20130101) Original (OR) Class
G01S 13/888 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230289473 ARORA et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Mathematical Sciences (DMS)
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S) The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S) Sanjeev ARORA (Princeton, New Jersey);  Kai LI (Princeton, New Jersey);  Yangsibo HUANG (Princeton, New Jersey);  Zhao SONG (Princeton, New Jersey);  Danqi CHEN (Princeton, New Jersey)
ABSTRACT According to various embodiments, a method for encrypting image data for a neural network are disclosed. The method includes mixing the image data with other datapoints to form mixed data; and applying a pixel-wise random mask to the mixed data to form encrypted data. According to various embodiments, a method for encrypting text data for a neural network for natural language processing is disclosed. The method includes encoding each text datapoint via a pretrained text encoder to form encoded datapoints; mixing the encoded datapoints with other encoded datapoints to form mixed data; applying a random mask to the mixed data to form encrypted data; and incorporating the encrypted data into training a classifier of the neural network and fine-tuning the text encoder.
FILED Thursday, June 17, 2021
APPL NO 18/009765
CURRENT CPC
Electric Digital Data Processing
G06F 21/602 (20130101)
G06F 21/6254 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/098 (20230101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230289599 Sidhu et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Tesla, Inc. (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Harsimran Singh Sidhu (Fremont, California);  Paras Jagdish Jain (Cupertino, California);  Daniel Paden Tomasello (Los Altos Hills, California);  Forrest Nelson Iandola (San Jose, California)
ABSTRACT A model training and implementation pipeline trains models for individual embedded systems. The pipeline iterates through multiple models and estimates the performance of the models. During a model generation stage, the pipeline translates the description of the model together with the model parameters into an intermediate representation in a language that is compatible with a virtual machine. The intermediate representation is agnostic or independent to the configuration of the target platform. During a model performance estimation stage, the pipeline evaluates the performance of the models without training the models. Based on the analysis of the performance of the untrained models, a subset of models is selected. The selected models are then trained and the performance of the trained models are analyzed. Based on the analysis of the performance of the trained models, a single model is selected for deployment to the target platform.
FILED Tuesday, March 14, 2023
APPL NO 18/183515
CURRENT CPC
Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 13/027 (20130101)

Systems for Controlling or Regulating Non-electric Variables
G05D 1/0088 (20130101)
G05D 1/0214 (20130101)
G05D 1/0221 (20130101)
G05D 2201/0213 (20130101)

Electric Digital Data Processing
G06F 9/45533 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101) Original (OR) Class
G06N 3/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290145 Chaterji et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
Division of Computer and Network Systems (CNS)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Somali Chaterji (West Lafayette, Indiana);  Saurabh Bagchi (est Lafayette, Indiana);  Ran Xu (West Lafayette, Indiana)
ABSTRACT A system may receive video information. The system may select a combination of light-weight features and heavy weight features. The light-weight features may be extracted from the video information and the heavy weight features not extracted. The system may forecast, based on the light-weight features and the heavy weight features, accuracy, and latency metrics for performing the object detection and tracking using a plurality of candidate branch configurations, respectively. The system may select a branch configuration from the plurality of candidate branch configurations in response to satisfaction of an optimization criterion. The system may perform object detection and tracking based on the selected branch configuration.
FILED Friday, March 10, 2023
APPL NO 18/120285
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/20 (20130101)

Image or Video Recognition or Understanding
G06V 20/46 (20220101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290707 Avval et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Fayetteville, Arkansas)
ASSIGNEE(S) BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Fayetteville, Arkansas)
INVENTOR(S) Amirreza Ghadimi Avval (Fayetteville, Arkansas);  Samir El-Ghazaly (Fayetteville, Arkansas);  Gregory J. Salamo (Fayetteville, Arkansas);  Shui-Qing Yu (Fayetteville, Arkansas)
ABSTRACT A semiconductor heat sink made of a first material including a plurality of spaced-apart depressions and an area surrounding the depressions filled with one or more materials having a heat conductivity greater than the first material.
FILED Tuesday, January 17, 2023
APPL NO 18/155612
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 23/433 (20130101) Original (OR) Class
H01L 29/2003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290954 Baumann et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland);  Northwestern University (Evanston, Illinois)
ASSIGNEE(S) The Johns Hopkins University (Baltimore, Maryland);  Northwestern University (Evanston, Illinois)
INVENTOR(S) Avery E. Baumann (Baltimore, Maryland);  Van Sara Thoi (Baltimore, Maryland);  Julia R. Downing (Evanston, Illinois);  Mark C. Hersam (Evanston, Illinois)
ABSTRACT A composition for producing electrodes for lithium-sulfur batteries includes particles having a metal-organic framework structure and composition that define voids within the metal-organic framework structure; sulfur loaded into at least some of the voids defined by the metal-organic framework structure of the particles; graphene flakes obtained by polymer enhanced solvent exfoliation; and polymer residue from the polymer enhanced solvent exfoliation. A method of producing a composite electrode for a lithium-sulfur battery according to an embodiment of the current invention includes obtaining a composition according to an embodiment of the current invention and applying the composition to a substrate. An electrode for a lithium-sulfur battery includes a layer having the composition. A lithium-sulfur battery according to an embodiment of the current invention includes the electrode.
FILED Thursday, July 22, 2021
APPL NO 18/017372
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 32/19 (20170801)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/60 (20130101)
H01M 4/625 (20130101) Original (OR) Class
H01M 10/052 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230291203 Narayanaswamy et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) Vivek Sivaraman Narayanaswamy (Tempe, Arizona);  Rajapandian Ayyanar (Chandler, Arizona);  Cihan Tepedelenlioglu (Chandler, Arizona);  Andreas Spanias (Tempe, Arizona)
ASSIGNEE(S) Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona)
INVENTOR(S) Vivek Sivaraman Narayanaswamy (Tempe, Arizona);  Rajapandian Ayyanar (Chandler, Arizona);  Cihan Tepedelenlioglu (Chandler, Arizona);  Andreas Spanias (Tempe, Arizona)
ABSTRACT A system reconfigures a photovoltaic array used in solar energy based on observed shading conditions to determine an optimal topology of the photovoltaic array to maximize power output. Specifically, the system is designed to reconfigure a photovoltaic array when the photovoltaic array is partially shaded. The system uses a neural network model to determine a topology that maximizes power output of the photovoltaic array based on irradiance data obtained from the photovoltaic array.
FILED Tuesday, March 14, 2023
APPL NO 18/121388
CURRENT CPC
Systems for Regulating Electric or Magnetic Variables
G05F 1/67 (20130101)

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 3/004 (20200101) Original (OR) Class
H02J 2300/26 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230291541 Gupta et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
Division of Computer and Network Systems (CNS)
Office of Advanced Cyberinfrastructure (OAC)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Saransh Gupta (La Jolla, California);  Tajana Simunic Rosing (San Diego, California)
ABSTRACT A method of operating on encrypted data can be performed by receiving ciphertexts at a server that is configured to operate on the ciphertexts generated using a 3rd generation RGSW based fully homomorphic encryption system, operating on the ciphertexts received at the server in response to requested operations to generate respective input ciphertexts including ciphertext polynomials and ciphertext integers that are representative of the input ciphertexts, and processing the input ciphertexts in a server processing-in-memory device, that is operatively coupled to the server, to perform operations on the input ciphertext using the server processing-in-memory device, in-situ.
FILED Tuesday, January 10, 2023
APPL NO 18/152313
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/008 (20130101) Original (OR) Class
H04L 9/0825 (20130101)
H04L 9/3026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20230285446 Alverdy et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The University of Chicago (Chicago, Illinois);  UChicago Argonne, LLC (Chicago, Illinois)
ASSIGNEE(S) The University of Chicago (Chicago, Illinois);  UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S) John C. Alverdy (Glenview, Illinois);  Matthew Tirrell (Chicago, Illinois);  Olga Y. Zaborina (Brookfield, Illinois);  Jun Mao (Chicago, Illinois);  Wei Chen (Chicago, Illinois)
ABSTRACT The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.
FILED Wednesday, January 18, 2023
APPL NO 18/156058
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0095 (20130101)
A61K 31/77 (20130101) Original (OR) Class
A61K 31/80 (20130101)
A61K 31/765 (20130101)
A61K 47/10 (20130101)
A61K 47/34 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/00 (20180101)
A61P 31/04 (20180101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 65/3353 (20130101)
C08G 81/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286045 Bass et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
Idaho National Laboratory (INL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)
INVENTOR(S) Ryann E. Bass (Ammon, Idaho);  Jorgen Rufner (Idaho Falls, Idaho);  Michael D. McMurtrey (Idaho Falls, Idaho);  Xinchang Zhang (Idaho Falls, Idaho);  Troy B. Holland (New Albany, Indiana)
ABSTRACT A method of forming an article comprises placing a first material and a second material in a die of a direct current sintering apparatus. The second material directly contacts the first material. An electric current and pressure are applied to the first material and the second material to form an article. An additional method comprises placing a nickel-based material in direct contact with one or more other nickel-based materials to form a stack of nickel-based materials. An electric current and pressure are applied to the stack of nickel-based materials to join the nickel-based material and the one or more other nickel-based materials. Related articles are also disclosed.
FILED Tuesday, March 14, 2023
APPL NO 18/183513
CURRENT CPC
Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal
B21D 53/04 (20130101)

Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 7/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286158 Beer et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) N. Reginald Beer (Pleasanton, California);  David H. Chambers (Livermore, California);  Jeffrey Edward Mast (Loveland, Colorado)
ABSTRACT A system for generating a machine learning system to generate guidance information based on locations of objects is provided. The system accesses training data that includes training time-of-arrival (“TOA”) information of looks and guidance information for each look. The guidance information is based on a training collection of object locations. The TOA of a look represents, for each object location of a training collection of object locations, times between signals transmitted by transmitters and return signals received by receivers. The return signals represent signals reflected from an object at the object location. The system trains a machine learning system using the training data wherein the machine learning system inputs TOA information and outputs guidance information.
FILED Friday, May 12, 2023
APPL NO 18/316518
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/1676 (20130101) Original (OR) Class

Aeroplanes; Helicopters
B64C 39/024 (20130101)

Unmanned aerial vehicles [UAV]; equipment therefor
B64U 10/13 (20230101)

Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 13/02 (20130101)

Systems for Controlling or Regulating Non-electric Variables
G05D 1/0088 (20130101)
G05D 1/101 (20130101)

Image Data Processing or Generation, in General
G06T 7/70 (20170101)
G06T 2207/30252 (20130101)

Image or Video Recognition or Understanding
G06V 20/10 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230286489 Shakya et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) Cummins Inc. (Columbus, Indiana)
ASSIGNEE(S)
INVENTOR(S) Bijesh M. Shakya (Columbus, Indiana);  Kesavan Ramakrishnan (Columbus, Indiana)
ABSTRACT Emissions management systems for engines in hybrid systems include a sensor assembly and a controller. Sensor assembly is configured to provide an activation signal in response to an engine start event and to detect emissions information, including information indicative of an engine power, a driver demanded power, a catalyst temperature, a battery state of charge, and a battery temperature. Controller communicates with sensor assembly and is configured to: receive activation signal and, in response, emissions information from sensor assembly; determine an emissions reduction mode having a threshold value for catalyst temperature and having an engine power corresponding thereto; monitor emissions information; compare catalyst temperature to threshold value; cause the engine to operate in emissions reduction mode while catalyst temperature is less than threshold value; and allow the engine to operate in a normal operation mode while catalyst temperature is greater than or equal to the threshold value.
FILED Thursday, May 27, 2021
APPL NO 18/014403
CURRENT CPC
Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit
B60W 10/06 (20130101) Original (OR) Class
B60W 10/26 (20130101)
B60W 2510/244 (20130101)
B60W 2510/246 (20130101)
B60W 2710/0677 (20130101)

Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines
F01N 11/002 (20130101)
F01N 2590/11 (20130101)
F01N 2900/08 (20130101)
F01N 2900/104 (20130101)
F01N 2900/1602 (20130101)
F01N 2900/1626 (20130101)

Controlling Combustion Engines
F02D 29/02 (20130101)
F02D 41/062 (20130101)
F02D 41/0255 (20130101)
F02D 2200/0802 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287153 SCHMIDT et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
ASSIGNEE(S) GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
INVENTOR(S) Robert D. SCHMIDT (Howell, Michigan);  Shuru CHEN (Troy, Michigan);  Fang DAI (Troy, Michigan);  Mei CAI (Bloomfield Hills, Michigan)
ABSTRACT Methods for forming sulfur polyacrylonitrile are provide. In certain variations, the method includes contacting sulfur and polyacrylonitrile to form an admixture, sealing a container holding the admixture, heating the admixture to a first temperature venting the container holding the admixture to release gases generated during the heating of the admixture to the first temperature, re-sealing the container holding the admixture, and heating the admixture to a second temperature. In other variations, the method includes contacting sulfur and polyacrylonitrile to form an admixture, heating the admixture to a first temperature, sealing a container holding the admixture, and heating the admixture to a second temperature. The second temperature is greater than the first temperature.
FILED Wednesday, March 09, 2022
APPL NO 17/690831
CURRENT CPC
Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 8/36 (20130101) Original (OR) Class
C08F 120/44 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/0565 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287439 YOSHIKUNI et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Yasuo YOSHIKUNI (Orinda, California);  Gaoyan WANG (Pleasanton, California);  Zhiying ZHAO (Danville, California);  Robert Cameron COATES (Lafayette, California);  Jan-Fang CHENG (Orinda, California);  David ROBINSON (Martinez, California)
ABSTRACT Provided herein are methods for integrating a gene of interest into a chromosome of a host cell. In some embodiments, the methods include introducing into a host cell a first plasmid comprising a transposase coding sequence and a donor sequence, which includes a selectable marker coding sequence flanked by a first and a second lox site and is itself flanked by inverted repeats recognized by the transposase. Following transposase-mediated chromosomal integration of the donor sequence into the host cell, a second plasmid is introduced, which comprises the gene of interest and a second selectable marker coding sequence, both flanked by a first and a second lox site. The gene of interest is chromosomally integrated into the host cell by recombinase-mediated cassette exchange (RMCE) between the donor sequence and the second plasmid via Cre-lox recombination. Further provided herein are host cells, vectors, and methods of producing a product related thereto.
FILED Wednesday, May 03, 2023
APPL NO 18/311796
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/70 (20130101)
C12N 15/74 (20130101)
C12N 15/78 (20130101) Original (OR) Class
C12N 15/902 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287443 OIKAWA
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) AFINGEN, INC. (Emeryville, California)
ASSIGNEE(S) AFINGEN, INC. (Emeryville, California)
INVENTOR(S) Ai OIKAWA (Emeryville, California)
ABSTRACT The present invention provides compositions and methods for generating transgenic plants with increased plant growth and improved multiple yield-related traits, which comprise vascular xylem tissue-targeting overexpression of transcription factors (TFs) involved in vascular xylem cell development.
FILED Wednesday, February 22, 2023
APPL NO 18/172699
CURRENT CPC
Peptides
C07K 14/47 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/8223 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288342 LARSEN, III et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina);  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (ATHENS, Georgia)
ASSIGNEE(S)
INVENTOR(S) GEORGE K. LARSEN, III (AIKEN, South Carolina);  THO D. NGUYEN (DACULA, Georgia);  MINH THIEN PHAM (FALLS CHURCH, Virginia);  HOANG M. LUONG (ATHENS, Georgia)
ABSTRACT Hydrogen gas sensors with low cost, fast response time, large detection range, high sensitivity, and excellent limit of detection are described. The devices include a composite formed on a nano-scale that both absorbs hydrogen and exhibits magneto-optical effects. Sensor readout is based on magneto-optical effects, which also may be enhanced through plasmonic coupling. The hydrogen sensors are fast and sensitive, as well as resistant to surface poisoning from common contaminants, such as carbon monoxide.
FILED Thursday, February 02, 2023
APPL NO 18/105071
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/77 (20130101) Original (OR) Class
G01N 21/554 (20130101)
G01N 33/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288352 Sun et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Chengjun Sun (Naperville, Illinois);  Mikhail A. Solovyev (Western Springs, Illinois);  Steve Heald (Downers Grove, Illinois);  Xiaoyi Zhang (Naperville, Illinois);  Maria Chan (Chicago, Illinois);  Shelly D. Kelly (Bolingbrook, Illinois)
ABSTRACT Spectroscopy systems require a crystal having specific properties for analyzing a spectrum of a sample, which is typically performed for measuring the presence of one element at a time. A two-dimensional (2D) crystal mount for performing simultaneous spectroscopy measurements includes a crystal holder having multiple rows of crystal mounts. Each crystal mount is positioned and orientated to physically support a crystal at a fixed position and fixed orientation relative to an optical axis. A sample provides radiation to analyzer crystals disposed in the crystal mounts, and a detector may detect radiation reflected from the analyzer crystals, for performing multiple simultaneous spectroscopy measurements.
FILED Friday, March 11, 2022
APPL NO 17/692994
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 23/2076 (20130101) Original (OR) Class
G01N 23/20008 (20130101)
G01N 2223/308 (20130101)
G01N 2223/0568 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288362 Aytug et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Tolga Aytug (Oak Ridge, Tennessee);  Christine Fisher (Oak Ridge, Tennessee);  Pooran C. Joshi (Oak Ridge, Tennessee);  Robert J. Warmack (Oak Ridge, Tennessee)
ABSTRACT A low-cost and low-power polyaniline-based (PANI) gas sensor is provided. The PANI-based gas sensor is formed on a flexible polyimide (PI) substrate using additive manufacturing techniques. The gas sensor can include silver interdigitated electrode (IDE) arrays and conducting polymeric sensing films (i.e., PANI) that are printed onto the PI substrate using a direct-write technology of aerosol-jet printing. Aerosol-jet printing enables high-resolution, non-contact deposition of both the electrode and chemically sensitive materials. The gas sensor is optionally capable of 5 ppm sensitivity and a sub-ppm detection limit.
FILED Wednesday, March 08, 2023
APPL NO 18/118920
CURRENT CPC
Printing, Duplicating, Marking, or Copying Processes; Colour Printing,
B41M 3/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/127 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288375 Jacobson et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Los Alamos National Laboratory (LANL)
Federally Funded Research and Development Center (FFRDC)
Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S) Chevron U.S.A. Inc. (San Ramon, California);  Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Erica Marie Jacobson (Los Alamos, New Mexico);  Ian Thomas Cummings (Los Alamos, New Mexico);  Eric Brian Flynn (Santa Fe, New Mexico);  Adam Joseph Wachtor (Los Alamos, New Mexico);  Benjamin M. Chaloner-Gill (Alameda, California);  Brock Genter (San Ramon, California);  Martin Quintero (Houston, Texas);  Ryan S. Sanders (Helena, Montana)
ABSTRACT A structure including a substrate and a coating over the substrate is acoustically excited to measure acoustic response in the structure. The measured acoustic response in the structure is filtered to remove acoustic response of the substrate and determine acoustic response of the coating. The acoustic response of the coating is used to inspect the coating for failure.
FILED Sunday, March 13, 2022
APPL NO 17/693369
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 29/07 (20130101) Original (OR) Class
G01N 29/4427 (20130101)
G01N 29/4463 (20130101)
G01N 2291/011 (20130101)
G01N 2291/0237 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230288692 Ravizza
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Frank Ravizza (Livermore, California)
ABSTRACT In one aspect, an apparatus includes a first aspheric refractive surface defined by a first polynomial and positioned to receive input light, and a first aspheric mirror surface comprising a first reflective coating, the first mirror surface defined by a second polynomial and positioned to receive light from the first aspheric refractive surface. The apparatus includes a second aspheric mirror surface comprising a second reflective coating, the second aspheric mirror surface defined by a third polynomial and positioned to receive light from the first aspheric mirror surface, and a second aspheric refractive surface defined by a fourth polynomial and positioned to receive light from the second aspheric mirror surface, wherein the first aspheric refractive surface, the first aspheric mirror surface, the second aspheric mirror surface, and the second aspheric refractive surface are arranged to have a fixed alignment with respect to each other as part of a monolithic structure.
FILED Monday, March 14, 2022
APPL NO 17/654775
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 17/0808 (20130101)
G02B 23/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230289644 Rosenthal et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Eric I. Rosenthal (San Mateo, California);  Christopher P. Anderson (Menlo Park, California);  Jelena Vuckovic (Palo Alto, California)
ABSTRACT Improved spin-microwave coupling is provided using a microwave cavity having a galvanic element connecting two points on its walls. This configuration can provide an unusual cavity mode having a highly concentrated magnetic field (to provide good coupling to a spin system) and a spread-out electric field (to reduce loss, since the electric field is almost entirely in vacuum). The galvanic element preferably includes a nano-scale current concentration feature (i.e., sub 100 nm lateral dimensions) to concentrate the magnetic field. The spin system of interest is preferably disposed in proximity to this current concentration feature. Applications include coherent quantum optical-microwave transduction and quantum memories.
FILED Tuesday, March 14, 2023
APPL NO 18/121412
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 10/40 (20220101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290525 GATES et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Princeton Plasma Physics Laboratory (PPPL)
Federally Funded Research and Development Center (FFRDC)
Operated by Princeton University (PRINCETON) at Princeton, NJ
APPLICANT(S) THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S)
INVENTOR(S) DAVID GATES (PRINCETON, New Jersey);  CAOXIANG ZHU (Hefei, China PRC);  KENNETH HAMMOND (Plainsboro, New Jersey)
ABSTRACT Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.
FILED Friday, March 10, 2023
APPL NO 18/119981
CURRENT CPC
Fusion Reactors
G21B 1/055 (20130101) Original (OR) Class

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 6/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290925 Deng et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Zenlabs Energy, Inc. (Fremont, California)
ASSIGNEE(S)
INVENTOR(S) Haixia Deng (Fremont, California);  Yongbong Han (San Francisco, California);  Charan Masarapu (Fremont, California);  Yogesh Kumar Agunchamy (Newark, California);  Herman A. Lopez (Sunnyvale, California);  Sujeet Kumar (Newark, California)
ABSTRACT Silicon oxide based materials, including composites with various electrical conductive compositions, are formulated into desirable anodes. The anodes can be effectively combined into lithium ion batteries with high capacity cathode materials. In some formulations, supplemental lithium can be used to stabilize cycling as well as to reduce effects of first cycle irreversible capacity loss. Batteries are described with surprisingly good cycling properties with good specific capacities with respect to both cathode active weights and anode active weights.
FILED Friday, May 12, 2023
APPL NO 18/196512
CURRENT CPC
Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties
H01B 1/122 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/131 (20130101) Original (OR) Class
H01M 4/134 (20130101)
H01M 4/136 (20130101)
H01M 4/386 (20130101)
H01M 4/483 (20130101)
H01M 4/505 (20130101)
H01M 4/525 (20130101)
H01M 4/583 (20130101)
H01M 4/624 (20130101)
H01M 10/052 (20130101)
H01M 10/0525 (20130101)
H01M 10/0569 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290952 Vanderburgh et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Kathleen E. Vanderburgh (San Mateo, California);  Francesco Fornasiero (Oakland, California);  Jianchao Ye (Tracy, California)
ABSTRACT Carbon nanotube (CNT) forests are grown directly on a base material for an anode. The CNTs are filled with Li metal. The filling behavior of the CNTs with Li metal is governed by the density, height, and diameter of the CNTs in the forest. These parameters are controlled by modifying the chemical vapor deposition (CVD) recipe used to grow the CNT forest along with adjusting the catalyst stack design to tune the aspect ratio, density, and rigidity of the CNT forest.
FILED Monday, March 14, 2022
APPL NO 17/694030
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 16/06 (20130101)
C23C 16/26 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/382 (20130101)
H01M 4/0404 (20130101)
H01M 4/0428 (20130101)
H01M 4/625 (20130101) Original (OR) Class
H01M 4/661 (20130101)
H01M 4/663 (20130101)
H01M 4/1395 (20130101)
H01M 10/0525 (20130101)
H01M 2004/027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230292632 Harris et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
Federally Funded Research and Development Center (FFRDC)
Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Charles Thomas Harris (Albuquerque, New Mexico);  Sueli Del Carmen Skinner Ramos (Albuquerque, New Mexico);  William F. Kindel (Albuquerque, New Mexico);  Rupert M. Lewis (Albuquerque, New Mexico);  Matt Eichenfield (Albuquerque, New Mexico)
ABSTRACT Josephson junctions are the main circuit element of superconducting quantum information devices due to their nonlinear inductance properties and fabrication scalability. However, large scale integration necessarily depends on high fidelity and high yielding fabrication of Josephson junctions. The standard Josephson junction technique depends on a submicron suspended resist Dolan bridge that tends to be very fragile and fractures during the fabrication process. The present invention is directed to a new tunnel junction resist mask that incorporates stress-relief channels to reduce the intrinsic stress of the resist, thereby increasing the survivability of the Dolan bridge during device processing, resulting in higher Josephson junction yield.
FILED Thursday, March 09, 2023
APPL NO 18/119366
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 10/40 (20220101)

Electric solid-state devices not otherwise provided for
H10N 60/12 (20230201) Original (OR) Class
H10N 60/805 (20230201)
H10N 60/855 (20230201)
H10N 60/0912 (20230201)
H10N 69/00 (20230201)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20230284598 Buccafusca et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) HiveTech Solutions Inc. (Wilmington, Delaware)
ASSIGNEE(S) HiveTech Solutions Inc. (Wilmington, Delaware)
INVENTOR(S) Osvaldo Buccafusca (Fort Collins, Colorado);  Kimberly A. Drennan (Boulder, Colorado);  Chelsea Cook (Phoenix, Arizona);  Daniel Rubenstein (Boulder, Colorado)
ABSTRACT A mobile enclosure system includes a container and subsystems, including at least one of: a heating unit, a cooling unit, a humidity control unit, and a gas/vapor input unit. The system also includes sensors for monitoring environmental conditions within the container and generating environmental data, and a control unit connected with the subsystems and the sensors. The container includes a mobile foundation and a structural envelope on top of the mobile foundation. The control unit is configured for tracking power consumption by the plurality of subsystems coupled with the container, receiving the environmental data from the plurality of sensors, and modifying at least one operating parameter of the plurality of subsystems in accordance with the environmental data. In embodiments, the structural envelope is a permanent structure or includes insulated panels configured for repeated assembly and disassembly. The system may be compatible with multiple add-on packages for different applications.
FILED Monday, May 22, 2023
APPL NO 18/200454
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 47/06 (20130101) Original (OR) Class
A01K 51/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230284641 MCHUGH et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia);  UNIVERSITY OF CALIFORNIA AT BERKELEY (Berkeley, California)
ASSIGNEE(S)
INVENTOR(S) TARA H. MCHUGH (ALBANY, California);  CRISTINA BILBAO-SAINZ (ALBANY, California);  MATTHEW J. POWELL-PALM (BOZEMAN, Montana);  BORIS RUBINSKY (EL CERRITO, California)
ABSTRACT Fruits and vegetables are impregnated with ascorbic acid impregnation fluids during an isochoric freezing process. The ascorbic acid impregnation fluids are infused into the void pores of fruits and vegetables, without destroying cellular tissue. The infusion of ascorbic acid can prevent browning of fruits and vegetable products, increase the products' vitamin C content, and inhibit microbial growth.
FILED Friday, March 11, 2022
APPL NO 17/692784
CURRENT CPC
Preserving, e.g by Canning, Meat, Fish, Eggs, Fruit, Vegetables, Edible Seeds; Chemical Ripening of Fruit or Vegetables; the Preserved, Ripened, or Canned Products
A23B 7/10 (20130101) Original (OR) Class
A23B 7/055 (20130101)
A23B 7/154 (20130101)

Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 19/03 (20160801)
A23L 33/15 (20160801)

Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages
A23V 2002/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287330 Talaat
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Adel M. Talaat (Madison, Wisconsin)
ABSTRACT Described herein is a mycobacterium mutant, comprising at least one mutation in at least one gene sequence encoding global gene regulators (GGRs) selected from the group consisting of sigH, sigL, sigE, ECF-1, and mixtures thereof, wherein the GGR gene is at least partially inactivated. Described herein also is a vaccine based on the mutant and a method of differentiating between subjects that have been infected with mycobacterium and subjects that have not been infected with mycobacterium or have been vaccinated with a mycobacterium vaccine.
FILED Friday, May 19, 2023
APPL NO 18/320834
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/04 (20130101)
A61K 2039/522 (20130101)

Peptides
C07K 14/35 (20130101)
C07K 14/195 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101) Original (OR) Class
C12N 1/36 (20130101)
C12N 15/1031 (20130101)
C12N 15/1136 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101)
C12Q 2600/156 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5695 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287340 Oatley et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Washington State University (Pullman, Washington)
ASSIGNEE(S) Washington State University (Pullman, Washington)
INVENTOR(S) Jon Michael Oatley (Pullman, Washington);  Melissa Joan Oatley (Pullman, Washington)
ABSTRACT This disclosure provides improved method, kits, and systems and for isolating and enriching spermatogonial stem cells (SSCs) from livestock animal testicular tissue. In one aspect, the disclosure provides a method for enriching SSCs from a population of testis-derived cells containing at least one SSC, where the method comprises contacting the population of testis-derived cells to a culture media comprising, or that is preconditioned with, endothelial feeder cells, and maintaining culture conditions suitable for SSC cell maintenance and enrichment. In some embodiments, the media and culture conditions comprise one or more growth factors selected from GDNF, FGF2, SDF-1a, CSF-1, FDGF, NGF, and TGF-β, in any combination. In exemplary embodiments, the SSCs are porcine or bovine SSCs.
FILED Tuesday, July 27, 2021
APPL NO 18/006009
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/52 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/061 (20130101) Original (OR) Class
C12N 2501/13 (20130101)
C12N 2501/15 (20130101)
C12N 2501/21 (20130101)
C12N 2501/22 (20130101)
C12N 2501/115 (20130101)
C12N 2502/28 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287443 OIKAWA
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) AFINGEN, INC. (Emeryville, California)
ASSIGNEE(S) AFINGEN, INC. (Emeryville, California)
INVENTOR(S) Ai OIKAWA (Emeryville, California)
ABSTRACT The present invention provides compositions and methods for generating transgenic plants with increased plant growth and improved multiple yield-related traits, which comprise vascular xylem tissue-targeting overexpression of transcription factors (TFs) involved in vascular xylem cell development.
FILED Wednesday, February 22, 2023
APPL NO 18/172699
CURRENT CPC
Peptides
C07K 14/47 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/8223 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290145 Chaterji et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
Division of Computer and Network Systems (CNS)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Somali Chaterji (West Lafayette, Indiana);  Saurabh Bagchi (est Lafayette, Indiana);  Ran Xu (West Lafayette, Indiana)
ABSTRACT A system may receive video information. The system may select a combination of light-weight features and heavy weight features. The light-weight features may be extracted from the video information and the heavy weight features not extracted. The system may forecast, based on the light-weight features and the heavy weight features, accuracy, and latency metrics for performing the object detection and tracking using a plurality of candidate branch configurations, respectively. The system may select a branch configuration from the plurality of candidate branch configurations in response to satisfaction of an optimization criterion. The system may perform object detection and tracking based on the selected branch configuration.
FILED Friday, March 10, 2023
APPL NO 18/120285
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/20 (20130101)

Image or Video Recognition or Understanding
G06V 20/46 (20220101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 20230284811 Hills et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Seth R. Hills (Richmond, Virginia);  GARRETT S. BULLOCK (Tuscaloosa, Alabama)
ABSTRACT An apparatus for assisting a user in donning a shoe is disclosed. The apparatus can have a body defining a U-shaped receptacle that is configured to extend across an upper surface of the shoe. The body can have a pair of legs that extend downwardly on respective sides of the body to respective lower edges. The body can have a highest portion opposite the lower edges of the pair of legs that is spaced from the lower edges of the legs by at least 2 inches along a vertical axis. The apparatus can further have a clip that is coupled to the body, the clip comprising an arm that is pivotable relative to the body. The arm can define a first clamping surface. A second clamping surface can face the first clamping surface. The first and second clamping surfaces can receive the tongue therebetween.
FILED Monday, March 13, 2023
APPL NO 18/182541
CURRENT CPC
Household or Table Equipment
A47G 25/82 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285217 Dillard
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Ebony Starlyn Dillard (Aiken, South Carolina)
ABSTRACT A device for controlling aspects of ambulatory (walking) gait control during physical therapy uses magnetic bodies, one worn on each ankle of the user. The magnet polarity of each body facing toward the median plane of the user is the same, and thus the magnetic bodies repel one another when in proximity to prevent the feet from crossing over one another during the swing phase of the walking gait and thereby reduce the potential for falls due to tripping.
FILED Thursday, February 02, 2023
APPL NO 18/104823
CURRENT CPC
Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body
A61H 3/00 (20130101) Original (OR) Class
A61H 2003/007 (20130101)
A61H 2201/1642 (20130101)
A61H 2205/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285416 Ren et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) Durect Corporation (Cupertino, California);  Virginia Commonwealth University (Richmond, Virginia);  The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Shunlin Ren (Richmond, Virginia);  Yaping Wang (Richmond, Virginia);  WeiQi Lin (Emerald Hills, California);  James E. Brown (Los Gatos, California);  Terrence Blaschke (Stanford, California)
ABSTRACT Aspects of the present disclosure include methods for treating at least one of insulin resistance, diabetes, and prediabetes, and, optionally, also non-alcoholic steatohepatitis (NASH). In practicing the subject methods, an effective amount of at least one compound selected from 25-hydroxycholesterol-3-sulfate (25HC3S), 25- hydroxycholesterol-disulfate (25HCDS), 27-hydroxycholesterol-3-sulfate (27HC3S), 27- hydroxycholesterol-disulfate (27HCDS), 24-hydroxycholesterol-3-sulfate (24HC3S), 24- hydroxycholesterol-disulfate (24HCDS), and 24,25-epoxycholesterol-3-sulfate, or salt thereof is administered to the subject.
FILED Friday, June 25, 2021
APPL NO 18/008588
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/575 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287507 Jiang
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland);  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Feng Jiang (Ellicott City, Maryland)
ABSTRACT The present invention provides a method of predicting whether a pulmonary nodule in a subject is benign or non-small cell lung cancer, comprising obtaining the results of an assay that measures an expression level of miR205-5p in a plasma sample from the subject; obtaining the results of an assay that measures an expression level of miR126 in a plasma sample from the subject; obtaining the results of an assay that provides a size of the pulmonary nodule in the subject; and calculating a probability value based on the combination of the expression levels of miR205-5p and miR126, and the size of the pulmonary nodule, wherein if the probability value exceeds a specified threshold, the pulmonary nodule is predicted as non-small cell lung cancer.
FILED Tuesday, November 22, 2022
APPL NO 17/992668
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101)
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2525/207 (20130101)
C12Q 2561/113 (20130101)
C12Q 2600/178 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230291143 SHIRE et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  The United States as represented by the Department of Veterans Affairs (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Douglas Bourne SHIRE (Cleveland, Ohio);  Dustin J. TYLER (Cleveland, Ohio);  Janet L. GBUR (Cleveland, Ohio)
ABSTRACT An inline implantable connector device can provide an increased volume density to medical device systems in a limited volume. The inline implantable connector device can have a claim-shell design with a first half and a second half, each having a conductive path in a same design. The second half is turned and flipped by 180 degrees to mate with the first half so that the conductive paths interconnect to form electrical and mechanical interconnections that are fundamentally transverse to the direction of the incoming or outgoing lead wires. A first screw hole on a top side of the connector device can accept a screw therethrough; and a second screw hole on a bottom side of the connector device can accept another screw therethrough.
FILED Thursday, July 15, 2021
APPL NO 18/015357
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/375 (20130101)

Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors
H01R 13/621 (20130101) Original (OR) Class
H01R 24/58 (20130101)
H01R 2201/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 20230284851 Krasnobaev
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Natick Soldier Systems Center (NSSC)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
APPLICANT(S) Vivonics, Inc. (Bedford, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Leonid Krasnobaev (Framingham, Massachusetts)
ABSTRACT A particle collection system and method including a collection inlet aimable at a surface from which particles are to be collected, and a rotatable fixture including at least a pair of nozzles about the collection inlet also aimable at the surface and fluidly connected to a source of compressed fluid in order to dislodge particles from the surface. The rotatable fixture is rotated to generate, as the nozzles rotate about the collection inlet, a vortex dislodging and picking up particles on the surface, entraining the particles, and carrying the particles to the collection inlet.
FILED Monday, February 27, 2023
APPL NO 18/174841
CURRENT CPC
Domestic Washing or Cleaning; Suction Cleaners in General
A47L 9/0416 (20130101)
A47L 9/1666 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230285699 Locke et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) James P. Locke (Houston, Texas);  Holly P. Newton (Houston, Texas);  Mark E. Schaefbauer (Houston, Texas);  Molly E. Harwood (Houston, Texas)
ABSTRACT Presented are manual ventilator systems, methods for making/using such ventilator systems, and clamshell, accordion-style ventilators operable by a lone operator. A ventilator device includes first and second panels pivotably attached together in a clamshell configuration. Each panel has an inlet port, an outlet port, and an internal channel that fluidly connects the inlet and outlet ports. A one-way valve is fluidly connected to the first panel’s outlet port and restricts airflow therethrough in one direction. Another one-way valve is fluidly connected to the second panel’s inlet port and restricts airflow therethrough in an opposite direction. A concertinaed bellows is fluidly connected to the first panel’s outlet port and the second panel’s inlet port. The bellows is sandwiched between and attached to the two panels such that pivoting the panels away from each other expands and fills the bellows whereas pivoting the panels towards each other compresses and evacuates the bellows.
FILED Wednesday, June 02, 2021
APPL NO 17/999875
CURRENT CPC
Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 16/0075 (20130101) Original (OR) Class
A61M 16/208 (20130101)
A61M 2205/071 (20130101)
A61M 2205/8281 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287065 Zhang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S) Fuzhong Zhang (St. Louis, Missouri);  Christopher H. Bowen (St. Louis, Missouri);  Bin Dai (St. Louis, Missouri)
ABSTRACT The present disclosure is directed to systems and methods for synthesizing a spidroin. In some embodiments, the methods comprise synthesizing a monomer in vivo in a heterologous host, the monomer comprising an N-terminus IntC domain and a C-terminus IntN domain, and post-translationally polymerizing the synthesized monomer via in vitro split-intein mediated polymerization.
FILED Thursday, April 27, 2023
APPL NO 18/308301
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 48/05 (20190201)

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2089/00 (20130101)
B29K 2995/0088 (20130101)

Peptides
C07K 14/43518 (20130101) Original (OR) Class
C07K 2319/21 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
C12N 15/70 (20130101)

Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons
D01D 1/02 (20130101)
D01D 5/06 (20130101)

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 4/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230287443 OIKAWA
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) AFINGEN, INC. (Emeryville, California)
ASSIGNEE(S) AFINGEN, INC. (Emeryville, California)
INVENTOR(S) Ai OIKAWA (Emeryville, California)
ABSTRACT The present invention provides compositions and methods for generating transgenic plants with increased plant growth and improved multiple yield-related traits, which comprise vascular xylem tissue-targeting overexpression of transcription factors (TFs) involved in vascular xylem cell development.
FILED Wednesday, February 22, 2023
APPL NO 18/172699
CURRENT CPC
Peptides
C07K 14/47 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/8223 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290276 BURAS et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) TIENOVIX, LLC (Houston, Texas)
ASSIGNEE(S)
INVENTOR(S) William R. BURAS (Friendswood, Texas);  Craig S. RUSSELL (League City, Texas);  Kyle Q. NGUYEN (League City, Texas)
ABSTRACT Methods for providing real-time, three-dimensional (3D) augmented reality (AR) feedback guidance to a user of an equipment system for training or improved performance, including comparing sensed, real-time user positioning data and data received from the equipment system during use to reference positioning and procedure outcome data, and generating and providing to a user real-time position-based and outcome-based 3D AR feedback based on comparing the sensed and reference data.
FILED Wednesday, May 17, 2023
APPL NO 18/318769
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 8/06 (20130101)
A61B 8/52 (20130101)
A61B 8/085 (20130101)
A61B 8/466 (20130101)
A61B 8/467 (20130101)
A61B 8/4245 (20130101)
A61B 8/4254 (20130101)
A61B 8/4263 (20130101)
A61B 34/20 (20160201)
A61B 90/361 (20160201)
A61B 2090/365 (20160201)

Optical Elements, Systems, or Apparatus
G02B 27/017 (20130101)

Electric Digital Data Processing
G06F 3/011 (20130101)
G06F 3/016 (20130101)

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams
G09B 5/065 (20130101)
G09B 23/286 (20130101) Original (OR) Class

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 30/20 (20180101)
G16H 40/63 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Commerce (DOC) 

US 20230288200 EKHOLM
FUNDED BY
Department of Commerce (DOC)
National Oceanic and Atmospheric Administration (NOAA)
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Woods Hole Oceanographic Institution (Woods Hole, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Alexander K. EKHOLM (Falmouth, Massachusetts)
ABSTRACT A device and method of using same having an inertial measurement unit (IMU), a controller, an activator, and an absolute position sensor configured to measure fluid-body waves. The controller calculates its orientation in a relative frame using data obtained from the IMU and fixed-point arithmetic. The controller transforms the relative orientation information into absolute units using data obtained from the absolute sensor and fixed-point arithmetic, producing wave measurements. The controller may then select a subset of wave measurements for transmission via an optional communications mechanism to a remote user.
FILED Saturday, March 11, 2023
APPL NO 18/120365
CURRENT CPC
Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry
G01C 13/004 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230290891 Wu et al.
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S) Peng Wu (Cambridge, Massachusetts);  Joerg Appenzeller (West Lafayette, Indiana)
ABSTRACT A cross-coupled tunnel diode (XTD) device with large peak-to-valley current ratio (PVCR) is disclosed. A memory cell circuit comprising XTD devices is also disclosed. The XTD device includes an N-type semiconductor coupled to a P-type semiconductor. A first gate is disposed on the N-type semiconductor and a second gate is disposed on the P-type semiconductor. The first gate is coupled to the output terminal, which is further coupled to the P-type semiconductor. The second gate is coupled to the input terminal, which is coupled to the N-type semiconductor. As reverse bias voltage increases, band-to-band tunneling from valence band to conduction band initially generates increasing current, but the rising bias voltage closes the band to band tunneling window, creating a gated negative differential resistance behavior. The current drops off as the bias voltage further increases. In some examples, a ratio of peak-to-valley current ratio may exceed 103 or 105.
FILED Wednesday, March 09, 2022
APPL NO 17/690417
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/11 (20130101)
H01L 29/88 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20230292016 ZHU et al.
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) University of Maryland, College Park (College Park, Maryland);  Government of the United States of America as Represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)
INVENTOR(S) Wenqi ZHU (Vienna, Virginia);  Amit Kumar AGRAWAL (Rockville, Maryland);  Lu CHEN (Gaithersburg, Maryland);  Henri J. LEZEC (Silver Spring, Maryland)
ABSTRACT A chiral light-field optical imaging camera incorporating an array of photonic spin-multiplexed bifocal metalenses. Combined with a novel deep learning-based neural network reconstruction algorithm, the system provides distinct aberration-free photographic capabilities, including the ability to achieve a polarization controllable extremely large depth-of-field optical imaging across a range of distances within a range covering at least five orders of magnitude in absence of moving a part of the camera and based on a single exposure of an optical detector while maintaining high spatial lateral resolution.
FILED Friday, March 10, 2023
APPL NO 18/181966
CURRENT CPC
Pictorial Communication, e.g Television
H04N 13/232 (20180501)
H04N 23/55 (20230101)
H04N 23/957 (20230101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Homeland Security (DHS) 

US 20230287596 Kanatzidis et al.
FUNDED BY
Department of Homeland Security (DHS)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Mercouri G. Kanatzidis (Wilmette, Illinois);  Wenwen Lin (Willowbrook, Illinois)
ABSTRACT Methods for purifying reaction precursors used in the synthesis of inorganic compounds and methods for synthesizing inorganic compounds from the purified precursors are provided. Also provided are methods for purifying the inorganic compounds and methods for crystallizing the inorganic compounds from a melt. γ and X-ray detectors incorporating the crystals of the inorganic compounds are also provided.
FILED Wednesday, April 26, 2023
APPL NO 18/139605
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 19/007 (20130101)

Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 15/00 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2006/40 (20130101)

Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 9/04 (20130101)
C30B 11/00 (20130101)
C30B 13/06 (20130101)
C30B 13/34 (20130101)
C30B 23/06 (20130101)
C30B 35/007 (20130101) Original (OR) Class

Measurement of Nuclear or X-radiation
G01T 1/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Justice (DOJ) 

US 20230288457 VABNICK et al.
FUNDED BY
Department of Justice (DOJ)
Federal Bureau of Investigation (FBI)
APPLICANT(S) Federal Bureau of Investigation (Washington, District of Columbia)
ASSIGNEE(S) The United States of America as represented by the Federal Bureau of Investigation, Dept. of Justice (Washington, District of Columbia)
INVENTOR(S) Ian B. VABNICK (Fredericksburg, Virginia);  Michael MALONE (Quantico, Virginia)
ABSTRACT Circuit test devices and methods are provided. The method includes measuring a voltage between first and second conductor points (CPs) of a circuit under test (CUT), and determining if the measured voltage is less than a low voltage threshold value (LVTV) indicative of electrical continuity (EC) between the first and second CPs. In response to determining that the measured voltage is less than the LVTV, the method includes: transmitting a test signal (TS) to the first or second CP, and determining if the test signal is received after being transmitted. In response to determining that the TS is received, a presence of EC between the first and second conductor points is reported, and in response to determining that the TS is not received, absence of EC between the first and second CPs, or a lack of electrical contact between the VMC and the first and/or second CP(s), is reported.
FILED Tuesday, November 29, 2022
APPL NO 18/071415
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 19/16504 (20130101) Original (OR) Class
G01R 19/16528 (20130101)
G01R 31/54 (20200101)
G01R 31/58 (20200101)
G01R 31/3277 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Geospatial Intelligence Agency (NGA) 

US 20230289936 Breish et al.
FUNDED BY
National Geospatial Intelligence Agency (NGA)
APPLICANT(S) DIGITAL CHECK CORP. (NORTHBROOK, Illinois)
ASSIGNEE(S)
INVENTOR(S) Kurt Breish (Garden Valley, Idaho);  Torin Ford (Boise, Idaho)
ABSTRACT Image stitching from multiple line scanners may be provided by selecting, at a plurality of times while progressing a film roll from a supply reel to a take-up reel, overlap areas on the film roll between first and second field of views of a first and second line scan sensors that read first and second data streams from the film roll; calculating, at each time, a difference measure between the first and second data streams in a current overlap area for a current time; adjusting, based on the difference measure, a size or a position of the overlap area for use at a subsequent time as the film roll progresses such that the current overlap area has a first number of pixels and a subsequent overlap area has a second number of pixels; and blending the first and second data streams at the current time at the current overlap area.
FILED Monday, May 15, 2023
APPL NO 18/197551
CURRENT CPC
Image Data Processing or Generation, in General
G06T 5/50 (20130101) Original (OR) Class
G06T 7/0002 (20130101)
G06T 7/97 (20170101)
G06T 2207/10008 (20130101)
G06T 2207/20221 (20130101)
G06T 2207/20224 (20130101)

Pictorial Communication, e.g Television
H04N 1/00665 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Office of the Director of National Intelligence (ODNI) 

US 20230291419 Yoder
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Office of the Director of National Intelligence (ODNI)
Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) Theodore James Yoder (White Plains, New York)
ABSTRACT Techniques regarding quantum error correction are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a maximum-likelihood decoder component that executes a maximum-likelihood decoding algorithm to determine an error correction based on a decoding hypergraph that characterizes error-sensitive events associated with a quantum error-correcting code executed on a quantum circuit.
FILED Friday, March 11, 2022
APPL NO 17/654545
CURRENT CPC
Coding; Decoding; Code Conversion in General
H03M 13/01 (20130101)
H03M 13/09 (20130101)
H03M 13/1125 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 20230289599 Sidhu et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Tesla, Inc. (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Harsimran Singh Sidhu (Fremont, California);  Paras Jagdish Jain (Cupertino, California);  Daniel Paden Tomasello (Los Altos Hills, California);  Forrest Nelson Iandola (San Jose, California)
ABSTRACT A model training and implementation pipeline trains models for individual embedded systems. The pipeline iterates through multiple models and estimates the performance of the models. During a model generation stage, the pipeline translates the description of the model together with the model parameters into an intermediate representation in a language that is compatible with a virtual machine. The intermediate representation is agnostic or independent to the configuration of the target platform. During a model performance estimation stage, the pipeline evaluates the performance of the models without training the models. Based on the analysis of the performance of the untrained models, a subset of models is selected. The selected models are then trained and the performance of the trained models are analyzed. Based on the analysis of the performance of the trained models, a single model is selected for deployment to the target platform.
FILED Tuesday, March 14, 2023
APPL NO 18/183515
CURRENT CPC
Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 13/027 (20130101)

Systems for Controlling or Regulating Non-electric Variables
G05D 1/0088 (20130101)
G05D 1/0214 (20130101)
G05D 1/0221 (20130101)
G05D 2201/0213 (20130101)

Electric Digital Data Processing
G06F 9/45533 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101) Original (OR) Class
G06N 3/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Government Rights Acknowledged 

How To Use This Page 

THE FEDINVENT PATENT APPLICATION DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Thursday, September 14, 2023.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
     National Institutes of Health (NIH)
         National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
     Defense Advanced Research Projects Agency (DARPA)
         Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract is presented as it appears on the patent.

FILED
The date the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

  • A61B 1/149 (20130101)
  • A61B 1/71 (20130101)
  • A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230914.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

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