FedInvent™ Patent Applications
Application Details for Thursday, September 14, 2023
This page was updated on Friday, September 15, 2023 at 10:00 PM GMT
Department of Health and Human Services (HHS)
| US 20230284715 | Jayaraman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sundaresan Jayaraman (Atlanta, Georgia); Sungmee Park (Atlanta, Georgia) |
| ABSTRACT | An exemplary apparatus and method are disclosed for a respiratory protective device. The respiratory protective device can be customized to the facial profile of a user and ensure proper fit and operation of device and attached breathable filter. In some embodiments, the device is configured to continuously monitor, via an integrated sensor embedded in the device's frame, the fit or proper particulate-filtering operation of the respiratory protective device. The sensor embodiment can ensure proper operation of respiratory protective device while providing monitoring and tracking of the fit to ensure personal safety for the healthcare professionals wearing the device. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/162315 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/1107 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230284929 | Srinivasan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Shriya Sruthi Srinivasan (Cambridge, Massachusetts); Carlo Giovanni TRAVERSO (Newton, Massachusetts); Robert S. LANGER (Newton, Massachusetts); Amro A. Alshareef (Cambridge, Massachusetts) |
| ABSTRACT | The gastrointestinal capsule provides mechanical stimulation within the gastrointestinal tract. The capsule may be deployed in a subject's gastrointestinal tract orally by the subject ingesting the capsule. The capsule may mechanically stimulate any desired region within the gastrointestinal tract, including the stomach, small intestine, and large intestine. The mechanical stimulations provided by the capsule are applied to a portion of the inner walls or lining of a section of the gastrointestinal tract to simulate satiety. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/182832 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/073 (20130101) Original (OR) Class Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 23/0254 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285143 | Lederman et al. |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
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| INVENTOR(S) | Robert J. Lederman (Chevy Chase, Maryland); Toby Rogers (Washington, District of Columbia) |
| ABSTRACT | Systems and methods of atrioventricular valve replacement are provided. In various embodiments, an arch-like support structure is provided that is insertable and implantable into a heart and is positioned in the mitral annulus to replace a native mitral valve. The support structure is operable to support, and various systems comprise leaflet and chord structures operable to control and regular blood flow between chambers of the heart. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 18/006331 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2415 (20130101) A61F 2/2418 (20130101) Original (OR) Class A61F 2/2457 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285227 | Srinivasan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Shriya Sruthi Srinivasan (Cambridge, Massachusetts); Carlo Giovanni TRAVERSO (Newton, Massachusetts); Robert S. LANGER (Newton, Massachusetts); Amro A. Alshareef (Cambridge, Massachusetts) |
| ABSTRACT | An ingestible capsule includes a housing forming a cavity and having a textured outer surface. The textured outer surface forms a helical depression and a plurality of protruding studs disposed in the helical depression. The capsule further includes a therapeutic agent disposed in or on the housing. The capsule also includes a biodegradable coating on the textured outer surface of the housing, the biodegradable coating configured to dissolve in a fluid having a pH of 1.5 to 9. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/182854 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 23/0254 (20130101) Original (OR) Class A61H 2201/105 (20130101) A61H 2201/1692 (20130101) A61H 2201/5005 (20130101) A61H 2205/083 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 31/002 (20130101) A61M 2205/10 (20130101) A61M 2205/0238 (20130101) A61M 2210/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285292 | CHENG et al. |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Zhiliang CHENG (Newtown Square, Pennsylvania); Ling Q. QIN (Moorestown, New Jersey); Andrew B. TSOURKAS (Bryn Mawr, Pennsylvania); Yulong WEI (Hubei, China PRC); Beth A. WINKELSTEIN (Philadelphia, Pennsylvania); Sonia KARTHA (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions comprising a drug delivery system comprising a phospholipid that is hydrolyzed by phospholipase A2 (PLA2) enzyme and a drug. Also provided herein are methods for treating or for determining the location of a region to be treated or monitored in a subject in need thereof, the methods comprising: administering to the subject the disclosed composition. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 18/002681 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 31/688 (20130101) A61K 47/42 (20130101) A61K 49/1809 (20130101) A61K 49/1839 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) A61P 25/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285294 | Sadabad et al. |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
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| INVENTOR(S) | Raana Kashfi Sadabad (Stanford, California); Tulio A. Valdez (Stanford, California); Anping Xia (Stanford, California) |
| ABSTRACT | This application relates to various methods, agents, and systems for delivery of imaging and therapeutic agents to the middle and inner ear. On one aspect, there is a formulation provided in an ear drop form factor based on liposomal nanoparticles that penetrate the eardrum without an incision and can deliver therapeutic agents and/or contrast agents to the middle ear or therapeutic medications to the inner ear. |
| FILED | Friday, April 07, 2023 |
| APPL NO | 18/132290 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285299 | Elfar et al. |
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| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| ASSIGNEE(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| INVENTOR(S) | John Elfar (Rochester, New York); Kuang-Ching Tseng (Rochester, New York); Mark Noble (Brighton, New York) |
| ABSTRACT | Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery. |
| FILED | Friday, April 14, 2023 |
| APPL NO | 18/300703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/1647 (20130101) Original (OR) Class A61K 9/7007 (20130101) A61K 31/4409 (20130101) A61K 45/06 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285305 | Ma et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
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| INVENTOR(S) | Peter X. Ma (Ann Arbor, Michigan); Ming Dang (Maple Grove, Minnesota); Laurie K. McCauley (Ann Arbor, Michigan) |
| ABSTRACT | In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed. |
| FILED | Saturday, May 20, 2023 |
| APPL NO | 18/199939 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/204 (20130101) A61K 9/205 (20130101) A61K 9/2031 (20130101) Original (OR) Class A61K 9/5031 (20130101) A61K 9/7007 (20130101) A61K 38/29 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285322 | MCGOWAN et al. |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); Berg LLC (Framingham, Massachusetts); The Research Foundation for Mental Hygiene, Inc. (Menands, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York); Berg LLC (Framingham, Massachusetts); The Research Foundation for Mental Hygiene, Inc. (Menands, New York) |
| INVENTOR(S) | Josephine Cecelia MCGOWAN (New York, New York); Christine Ann DENNY (Ho-Ho-Kus, New Jersey); Michael KIEBISH (Framingham, Massachusetts) |
| ABSTRACT | Biomarkers for assessing the efficacy of prophylactic treatments of stress-induced affective disorders are provided. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/954858 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0043 (20130101) A61K 9/0053 (20130101) A61K 31/135 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/22 (20180101) A61P 25/24 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/30 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285328 | Koeberl et al. |
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| APPLICANT(S) | Duke University (Durham, North Carolina); National University of Singapore (Singapore, Singapore) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina); National University of Singapore (Singapore, Singapore) |
| INVENTOR(S) | Dwight D. Koeberl (Durham, North Carolina); Paul M. Yen (Singapore, Singapore); Benjamin L. Farah (Rocky River, Ohio) |
| ABSTRACT | The present disclosure is directed to methods of treating a steatosis-associated disorder by administering a therapeutic agent selected from a lysosomal enzyme, an autophagy-inducing agent, or a combination thereof. Steatosis-associated disorders discussed herein include GSD Ia, GSD Ib, GSD Ic, NAFLD, and NASH. Other embodiments are directed to methods of reversing steatosis, modulating autophagy, inducing autophagy, and reversing glycogen storage. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200156 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/12 (20130101) A61K 31/55 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 31/155 (20130101) A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 31/198 (20130101) A61K 31/216 (20130101) A61K 31/277 (20130101) A61K 31/352 (20130101) A61K 31/355 (20130101) A61K 31/385 (20130101) A61K 31/436 (20130101) A61K 31/522 (20130101) A61K 31/575 (20130101) A61K 31/5415 (20130101) A61K 31/7016 (20130101) A61K 33/00 (20130101) A61K 38/47 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Enzymes C12Y 301/04012 (20130101) C12Y 302/0102 (20130101) C12Y 302/01022 (20130101) C12Y 302/01045 (20130101) C12Y 302/01049 (20130101) C12Y 302/01076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285329 | Koeberl et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); National University of Singapore (Singapore, Singapore) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina); National University of Singapore (Singapore, Singapore) |
| INVENTOR(S) | Dwight D. Koeberl (Durham, North Carolina); Paul M. Yen (Singapore, Singapore); Benjamin L. Farah (Rocky River, Ohio) |
| ABSTRACT | The present disclosure is directed to methods of treating a steatosis-associated disorder by administering a therapeutic agent selected from a lysosomal enzyme, an autophagy-inducing agent, or a combination thereof. Steatosis-associated disorders discussed herein include GSD Ia, GSD Ib, GSD Ic, NAFLD, and NASH. Other embodiments are directed to methods of reversing steatosis, modulating autophagy, inducing autophagy, and reversing glycogen storage. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/12 (20130101) A61K 31/55 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 31/155 (20130101) A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 31/198 (20130101) A61K 31/216 (20130101) A61K 31/277 (20130101) A61K 31/352 (20130101) A61K 31/355 (20130101) A61K 31/385 (20130101) A61K 31/436 (20130101) A61K 31/522 (20130101) A61K 31/575 (20130101) A61K 31/5415 (20130101) A61K 31/7016 (20130101) A61K 33/00 (20130101) A61K 38/47 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Enzymes C12Y 301/04012 (20130101) C12Y 302/0102 (20130101) C12Y 302/01022 (20130101) C12Y 302/01045 (20130101) C12Y 302/01049 (20130101) C12Y 302/01076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285331 | MATHEW |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
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| INVENTOR(S) | SAJISH MATHEW (LEXINGTON, South Carolina) |
| ABSTRACT | Methods and compositions are described herein for modulating protein synthesis, especially monosome translation and DNA damage response, especially short-patch base excision repair (SP-BER), NHEJ and HR for treating a disorder. Compositions include a therapeutically effective amount of a tyrosine or a resveratrol derivative. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993027 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/164 (20130101) Original (OR) Class A61K 31/198 (20130101) A61K 31/405 (20130101) A61K 31/4164 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285338 | Colonna et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
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| INVENTOR(S) | Marco Colonna (St. Louis, Missouri); Tyler Ulland (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to a method for treating a microglial dysfunction-associated neurodegenerative disease in a subject in need thereof. The method includes administering to the subject a therapeutically effective amount of a composition comprising a microglia receptor agonist that directly activates SYK. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840368 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/195 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285346 | Zhao |
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| APPLICANT(S) | Ann and Robert H. Lurie Children's Hospital of Chicago (Chicago, Illinois) |
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| INVENTOR(S) | Youyang Zhao (Deerfield, Illinois) |
| ABSTRACT | Disclosed are methods of treating pulmonary hypertension. More specifically, disclosed herein are methods of treating pulmonary hypertension by administering a therapeutically effective amount of an alpha-ketoglutarate-dependent dioxygenase FTO (FTO) inhibitor to a subject. |
| FILED | Thursday, March 09, 2023 |
| APPL NO | 18/181231 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/205 (20130101) Original (OR) Class A61K 31/4178 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285401 | Zuo et al. |
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| APPLICANT(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| ASSIGNEE(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Zhuo Li (Omaha, Nebraska); Marisa Laura Zallocchi (Omaha, Nebraska) |
| ABSTRACT | In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. Momelotinib and Fedratinib exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice when administered prophylactically. In one aspect, Momelotinib or Fedratinib can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/084033 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/5377 (20130101) Original (OR) Class A61K 33/243 (20190101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285402 | Markowitz et al. |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Dallas, Texas); CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford Markowitz (Pepper Pike, Ohio); James K. V. Willson (Dallas, Texas); Bruce Posner (Richardson, Texas); Joseph Ready (Carrollton, Texas); Monika Antczak (Ft. Worth, Texas); Yongyou Zhang (Cleveland, Ohio); Amar Desai (Cleveland, Ohio); Stanton Gerson (Hunting Valley, Ohio); William Greenlee (Cleveland, Ohio); Sung Yeun Yang (Busan, South Korea); KiBeom Bae (Busan, South Korea) |
| ABSTRACT | Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/117257 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/444 (20130101) A61K 31/496 (20130101) A61K 31/519 (20130101) A61K 31/4365 (20130101) A61K 31/5377 (20130101) Original (OR) Class Heterocyclic Compounds C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285418 | Zuo et al. |
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| APPLICANT(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| ASSIGNEE(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Pezhman Salehi Dermanaki (Elkhorn, Nebraska); Marisa Laura Zallocchi (Omaha, Nebraska); Sarath Vijayakumar (Omaha, Nebraska) |
| ABSTRACT | Acquired hearing loss due to chemotherapy or noise exposure is a major health problem, and Cisplatin chemotherapy often causes permanent hearing loss in cancer patients. However, there are no FDA-approved drugs for the treatment or prevention of Cisplatin- or noise-induced hearing loss. In one aspect, use of Niclosamide, Ingenol, and Elesclomol as an active agent to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/081951 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) A61K 31/165 (20130101) A61K 31/397 (20130101) A61K 31/609 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285439 | Clarke et al. |
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| FUNDED BY |
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| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael F. Clarke (Stanford, California); Robert W. Hsieh (Stanford, California) |
| ABSTRACT | The invention is directed to methods of treating TNBC in a patient by administering to the patient an agent that inhibits the expression or activity of cyclin-dependent kinase 19 (CDK19). In some embodiments, the agent may be a small molecule inhibitor, a polynucleotide (e.g., shRNA. siRNA), or a protein (e.g., an antibody). In some embodiments, the agent does not inhibit the activity or expression of CDK8. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/823028 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285446 | Alverdy et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois); UChicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | John C. Alverdy (Glenview, Illinois); Matthew Tirrell (Chicago, Illinois); Olga Y. Zaborina (Brookfield, Illinois); Jun Mao (Chicago, Illinois); Wei Chen (Chicago, Illinois) |
| ABSTRACT | The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage. |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/156058 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0095 (20130101) A61K 31/77 (20130101) Original (OR) Class A61K 31/80 (20130101) A61K 31/765 (20130101) A61K 47/10 (20130101) A61K 47/34 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 31/04 (20180101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/3353 (20130101) C08G 81/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285464 | NGO et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | John T. NGO (Cambridge, Massachusetts); Jeffrey Blye MCMAHAN (Boston, Massachusetts) |
| ABSTRACT | Described herein are polypeptides, systems, and methods that relate to using domains that bind specifically to a biotinylamide to control receptor and cellular activity. |
| FILED | Friday, April 28, 2023 |
| APPL NO | 18/308899 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 16/28 (20130101) C07K 16/44 (20130101) C07K 16/2809 (20130101) C07K 16/2818 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) C07K 2319/60 (20130101) C07K 2319/71 (20130101) C07K 2319/74 (20130101) C07K 2319/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285499 | Szeto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York); University of Washington (Seattle, Washington) |
| INVENTOR(S) | Hazel H. Szeto (New York, New York); Peter S. Rabinovitch (Shoreline, Washington); Dao-Fu Dai (Seattle, Washington) |
| ABSTRACT | The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/079604 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/07 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Peptides C07K 5/0817 (20130101) C07K 5/1016 (20130101) C07K 5/1019 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285500 | Jurkunas |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ula V. Jurkunas (Winchester, Massachusetts) |
| ABSTRACT | This application discloses compositions and methods for treating corneal endothelium disorders (e.g., Fuchs endothelial corneal dystrophy) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants using gene therapy. |
| FILED | Tuesday, February 21, 2023 |
| APPL NO | 18/172062 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/00 (20130101) A61K 31/26 (20130101) A61K 31/385 (20130101) A61K 38/07 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285501 | Watnick |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Randolph S. Watnick (Newton, Massachusetts) |
| ABSTRACT | Disclosed herein are polypeptides and fusion polypeptides that have anti-angiogenic activity that can be used to inhibit tumor growth and tumor metastasis. The polypeptide consists of 9 or less consecutive amino acid residues (e.g., 8, 7, 6, 5, or 4) comprising the active core amino acid sequence DWLP, or an amino acid substitution variant thereof. Specific amino acid substitutions are disclosed herein. In some embodiments, the peptide consists essentially of 4-6 mers identified as exhibiting the activity of prosaposin A. Also disclosed herein are therapeutic compositions comprising the polypeptides and fusion polypeptides, and their use in the treatment, prevention, and inhibition of angiogenesis-related diseases and disorders such as cancer and cancer metastasis. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/103740 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 38/08 (20130101) Original (OR) Class A61K 39/39591 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 5/1019 (20130101) C07K 5/1021 (20130101) C07K 7/06 (20130101) C07K 14/475 (20130101) C07K 16/00 (20130101) C07K 2319/30 (20130101) C07K 2319/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 33/574 (20130101) G01N 33/5023 (20130101) G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285507 | SPEES |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Vermont and State Agriculture College (Burlington, Vermont) |
| ASSIGNEE(S) | The University of Vermont and State Agriculture College (Burlington, Vermont) |
| INVENTOR(S) | Jeffrey SPEES (Burlington, Vermont) |
| ABSTRACT | The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/159556 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) A61K 38/18 (20130101) Original (OR) Class A61K 38/28 (20130101) A61K 38/30 (20130101) Peptides C07K 14/65 (20130101) C07K 14/475 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285512 | Ardehali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reza Ardehali (Los Angeles, California); Ngoc Nguyen (Los Angeles, California); Peng Zhao (Los Angeles, California) |
| ABSTRACT | Provided herein are methods and compositions related to treating and preventing an age-related disease and inhibiting cell death using thymosin proteins. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/693978 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/2292 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285526 | Vujanovic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Nikola L. Vujanovic (Pittsburgh, Pennsylvania); Lazar Vujanovic (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods are disclosed for inhibiting the development of a tumor in a subject. The methods include administering to a subject a therapeutically effective amount of a dominant negative tumor necrosis factor (DN-TNF)-α protein and/or a nucleic acid encoding the DN-TNF-α protein. The DN-TNF-α protein and/or a nucleic acid encoding the DN-TNF-α protein can be administered alone or in combination with other agents. |
| FILED | Friday, March 10, 2023 |
| APPL NO | 18/182211 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2013 (20130101) A61K 38/2046 (20130101) A61K 38/2086 (20130101) A61K 39/00114 (20180801) A61K 39/001117 (20180801) Original (OR) Class A61K 39/001139 (20180801) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285536 | Kaplan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Kaplan (Concord, Massachusetts); Natalie Rubio (Medford, Massachusetts); Andrew Stout (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides animal cells that have been engineered to express one or more viral antigens. The engineered cells can be formulated into cultured meat products that can be used as edible vaccines. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 18/002899 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/5156 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 14/11 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0601 (20130101) C12N 5/0659 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285537 | Heaton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Scott Heaton (Durham, North Carolina); Alfred Theodore Harding (Durham, North Carolina); Brook Elizabeth Heaton (Durham, North Carolina) |
| ABSTRACT | Engineered Influenza polynucleotides, viruses, vaccines, and methods of making and using the same are provided. More specifically, the present inventors have developed replication competent engineered influenza viruses having, for example, a modified segment 4 and/or segment 6 that include at least one additional polynucleotide encoding a heterologous polypeptide. |
| FILED | Monday, January 30, 2023 |
| APPL NO | 18/103343 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/5252 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 14/00 (20130101) C07K 14/005 (20130101) C07K 14/11 (20130101) C07K 2319/42 (20130101) C07K 2319/50 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/2402 (20130101) C12N 15/86 (20130101) C12N 2760/16121 (20130101) C12N 2760/16122 (20130101) C12N 2760/16134 (20130101) C12N 2760/16143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285542 | Gill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harvinder Singh Gill (Lubbock, Texas); Gaurav Joshi (Lubbock, Texas) |
| ABSTRACT | The present invention includes and immunogenic composition and methods of immunizing a mammal or avian comprising: a nanoparticle conjugated to one or more antigenic peptides or fusion polypeptides from more than one strain of virus, wherein the one or more antigenic peptides or fusion polypeptides elicit at least one of a humoral, T helper cell-1 (Th1), T helper cell-2 (Th2) or cytotoxic T cell (CTL) immune response. In certain embodiments the antigenic peptides or fusion polypeptides are selected from at least one of SEQ IN NOS: 1 to 16, 22 to 39, or any combination thereof. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 18/006097 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/125 (20130101) A61K 39/145 (20130101) A61K 39/155 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 39/235 (20130101) A61K 2039/55572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285557 | NOLAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Garry P. NOLAN (Palo Alto, California); John W. HICKEY (Palo Alto, California) |
| ABSTRACT | The present disclosure relates generally to ex vivo expanded T cell populations suitable for use in adoptive immunotherapy. The disclosure also provides compositions and methods useful for preparing such ex vivo expanded T cell populations, as well as methods for the prevention and/or treatment of health conditions using the disclosed T cell populations. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 18/004636 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2501/999 (20130101) C12N 2501/2302 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285559 | Gu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| INVENTOR(S) | Zhen Gu (Los Angeles, California); Quanyin Hu (Los Angeles, California); Hongjun Li (Los Angeles, California) |
| ABSTRACT | A therapeutic hydrogel material is disclosed for the delivery of CAR-T cells that allows their distribution in the tumor resection recess, cavity, or void in combination with platelets decorated with the anti-programmed death-ligand 1 (PDL1) blocking antibody (aPDL1). The delivered hydrogel material acts as a reservoir for both CAR-T cells and platelet-bound aPDL1. Furthermore, inflammation occurring during the surgical wound healing triggers the release of platelet-derived microparticles containing the aPDL1. Cells delivered by the engineered hydrogel show significant control of local and distant tumor recurrence without causing toxic effects. In some embodiments, nanoparticles containing cytokines are also loaded in the therapeutic hydrogel material to maintain the activity and proliferation ability of CAR-T cells. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 18/015709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 38/2046 (20130101) A61K 38/2086 (20130101) A61K 39/4611 (20230501) A61K 39/4631 (20230501) Original (OR) Class A61K 47/36 (20130101) A61K 47/6843 (20170801) A61K 47/6901 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285568 | PEARSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | University of Maryland, Balltimore County (Baltimore, Maryland) |
| INVENTOR(S) | Ryan M. PEARSON (Baltimore, Maryland); Gregory SZETO (Seattle, Washington); Michael ZHANG (Baltimore, Maryland) |
| ABSTRACT | Phospholipid-conjugated Ags were used as an agnostic delivery platform to cell type, activation state, and inherent uptake capabilities for engineering APCs to control Ag-specific cellular immune responses. Lipid-mediated delivery (termed depoting) of MHC class I and II-restricted Ags successfully loaded resting polyclonal B cells, CD40− activated B cells, and DCs in a dose-dependent manner for priming Ag-specific CD8+ and CD4+ T cells, respectively. When lipid-conjugated Ags were paired with polymer-conjugated Ags and incorporated in nanoparticles (NPs), diverse APCs with varying NP internalization capabilities all processed the lipid-conjugated Ags via depoting while only DCs processed the PLGA-conjugated Ags via endocytosis. Multivariate analyses of cytokine secretions indicated that lipid-conjugated Ags could be distinctly classified from polymer-conjugated Ags. Lipid and PLGA carriers can be rationally paired with Ag combinations to leverage two distinct delivery systems that access multiple Ag processing pathways in diverse APCs, offering a modular delivery platform for engineering ASITs. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 18/040439 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/542 (20170801) A61K 47/543 (20170801) Original (OR) Class A61K 47/6929 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285591 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Benhur LEE (New York, New York); Karina PALOMARES (Los Angeles, California); Olivier PERNET (Los Angeles, California) |
| ABSTRACT | The present invention realtes to lentiviral particles which have been pseudotyped with Nipah virus (NiV) fusion (F) and attachment (G) glycoproteins (NiVpp-F/G). Additionally, the present invention relates to truncated NiV-F glyocproteins useful in producing such NiVpp lentiviral particles, as well as to additional variant peptides which enhance activity. Further, the present invention relates to methods of using such lentiviral particles or sequences, for example in the treatetment of cancer or CNS disorders. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/151174 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 48/00 (20130101) A61K 48/0008 (20130101) Original (OR) Class A61K 48/0075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2740/15021 (20130101) C12N 2740/15032 (20130101) C12N 2740/15041 (20130101) C12N 2740/15043 (20130101) C12N 2740/15071 (20130101) C12N 2760/18222 (20130101) C12N 2760/18232 (20130101) C12N 2760/18234 (20130101) C12N 2760/18241 (20130101) C12N 2760/18245 (20130101) C12N 2760/18271 (20130101) C12N 2810/6027 (20130101) C12N 2810/6072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285603 | Babich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | John W. Babich (New York, New York); James M. Kelly (New York, New York); Alejandro Amor-Coarasa (New York, New York); Shashikanth Ponnala (New York, New York) |
| ABSTRACT | The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 17/963823 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0402 (20130101) A61K 51/0482 (20130101) Original (OR) Class A61K 51/0497 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285636 | Alsberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); WORCESTER POLYTECHNIC INSTITUTE (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eben Alsberg (Cleveland, Ohio); Anna D. Dikina (Cleveland, Ohio); Marsha W. Rolle (Worcester, Massachusetts) |
| ABSTRACT | A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968476 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 27/3804 (20130101) A61L 27/3882 (20130101) Original (OR) Class A61L 2300/62 (20130101) A61L 2300/414 (20130101) A61L 2300/602 (20130101) A61L 2400/12 (20130101) A61L 2430/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0075 (20130101) C12N 2513/00 (20130101) C12N 2531/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285676 | Koska et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Koska Family Limited (East Sussex, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc Andrew Koska (Eastbourne, United Kingdom); Max Hannon (Flemingate, United Kingdom); Harris Ryder (Redruth, United Kingdom) |
| ABSTRACT | A pre-filled medical delivery assembly can have a blow-fill-seal (BFS) module, a manifold, and a casing. The BFS module can have a pair of reservoirs, and a pair of sealed ports. Each reservoir can have a respective liquid agent therein. Each port can be in fluid communication with a respective one of the reservoirs. Part of the BFS module can be inserted into the manifold, and the casing can protect part of the BFS module exposed from the manifold. An orientation of the casing can be reversed, and the casing can be used to push the BFS module into the manifold to breach the seals and/or to compress the reservoirs to dispense the liquid agents. The disclosed assemblies can combine the liquid agents from the BFS module and deliver the combination as a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) to a patient. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/141559 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/284 (20130101) A61M 5/2448 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285678 | Sakhrani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tribofilm Research, Inc. (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinay Sakhrani (Raleigh, North Carolina); Jackson D. Thornton (Raleigh, North Carolina) |
| ABSTRACT | The presently disclosed subject matter provides plasma-treated plastic syringe barrels with a plasma-treated lubricant coating and an interior surface with reduced number of particles as compared to an interior surface of a plastic syringe barrel with an untreated lubricant coating; plasma-treated plastic syringe barrels with a plasma-treated lubricant coating and an interior surface with extremely low surface density of particles; related syringes; related filled syringes with extremely low particle levels in solution; methods of treating the eye; methods of producing a plastic syringe barrel with a stable lubricant layer; related methods of producing a syringe; related syringes; and related methods of treating the eye. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 18/018483 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/3129 (20130101) Original (OR) Class A61M 2005/3131 (20130101) A61M 2205/0238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285731 | Falo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Louis D. Falo (Wexford, Pennsylvania); Geza Erdos (Wexford, Pennsylvania) |
| ABSTRACT | A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components can be combined with other components to exhibit specific release kinetics when the microneedle array is inserted into the skin of a patient. |
| FILED | Friday, April 28, 2023 |
| APPL NO | 18/141310 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285747 | Risi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cochlear Limited (Macquarie University, Australia); University of Washington Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank Risi (Newtown, Australia); Colin Irwin (Nice, France); Jay T. Rubinstein (Seattle, Washington); Felipe Santos (Boston, Massachusetts); James O. Phillips (Seattle, Washington) |
| ABSTRACT | A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures. |
| FILED | Thursday, May 11, 2023 |
| APPL NO | 18/315679 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/361 (20130101) A61N 1/0526 (20130101) Original (OR) Class A61N 1/0551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285755 | Grill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Warren Grill (Durham, North Carolina); Nicole Pelot (Durham, North Carolina); Minhaj Hussain (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes novel systems and methods to estimate the response of neurons to electrical stimulation and to determine the optimal electrode geometry and parameters of stimulation to activate or block specific targeted groups of neurons without activation or block of non-targeted groups of neurons. |
| FILED | Friday, March 10, 2023 |
| APPL NO | 18/182018 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36146 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) G06N 3/0442 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285784 | Jayaraman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sundaresan Jayaraman (Atlanta, Georgia); Sungmee Park (Atlanta, Georgia) |
| ABSTRACT | An exemplary system and method are disclosed for a respiratory protective device configured to continuously monitor, via an integrated sensor network embedded in the device's frame, the fit or proper particulate-filtering operation of the respiratory protective device. The system can ensure proper operation of respiratory protective device while providing monitoring and tracking of the fit to ensure personal safety for users wearing the device. In some embodiments, the system can monitor, track, and aggregate the data to present via a user interface to the user. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/162312 |
| CURRENT CPC | Devices, Apparatus or Methods for Life-saving A62B 18/02 (20130101) A62B 18/08 (20130101) A62B 27/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285967 | CRAIGHEAD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Harold G. CRAIGHEAD (Ithaca, New York); Sarah J. REINHOLT (Ithaca, New York) |
| ABSTRACT | The present invention relates to, inter alia, a microfluidic device for capturing target cells and analyzing genomic DNA isolated from the target cells while under flow conditions. The microfluidic device includes a cell microchannel and a nucleic acid microchannel that intersect in an orthogonal manner, thereby forming a cell capture intersection region. The microfluidic device also includes a cell capture array and a nucleic acid entanglement array. The cell capture array includes a plurality of cell capturing micropillars and is located in the cell capture intersection region. The nucleic acid entanglement array includes a plurality of nucleic acid entanglement micropillars that function to physically entangle and maintain thereon genomic DNA isolated from the one or more target cell, and is located in a portion of the nucleic acid microchannel that is adjacent to and downstream of the cell capture intersection region. Methods of using the microfluidic device are also disclosed. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/113553 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2200/0663 (20130101) B01L 2200/0668 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2400/086 (20130101) B01L 2400/0487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286920 | Raines et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald T. Raines (Cambridge, Massachusetts); Brian Gold (Albuquerque, New Mexico); Jesús M. Dones (Princeton, New Jersey); Nile S. Abularrage (Boston, Massachusetts); Brian James Graham (Belmont, Massachusetts) |
| ABSTRACT | Provided herein are dibenzocyclooctyne compounds useful as reagents in 1,3-dipolar cycloaddition reactions, and methods for their preparation. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/309977 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 13/547 (20130101) C07C 2603/36 (20170501) Heterocyclic Compounds C07D 221/16 (20130101) Original (OR) Class C07D 231/54 (20130101) C07D 249/16 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286922 | MELANDER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| ASSIGNEE(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| INVENTOR(S) | Christian MELANDER (South Bend, Indiana); Veronica HUBBLE (South Bend, Indiana) |
| ABSTRACT | We report improved adjuvant compounds that have an aryl 2-aminoimidazole structure for macrolide potentiation against a virulent strain of gram-negative bacteria, AB5075. Compounds were discovered to retain significant adjuvant activity at 10 μM, lowering the minimum inhibitory concentration (MIC) of clarithromycin (CLR) from 8-fold to 128-fold or greater. 2-Aminoimidazole compounds linked to aryl groups via either an amide or urea linker showed significantly improved activity over control compounds. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 18/000429 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4174 (20130101) A61K 31/7048 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 233/88 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286928 | BEATON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Epigen Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | Epigen Biosciences, Inc. (San Diego, California) |
| INVENTOR(S) | Graham BEATON (San Diego, California); Fabio C. TUCCI (San Diego, California); Satheesh B. RAVULA (San Diego, California); Chandravadan R. SHAH (San Diego, California); Suk Joong LEE (San Diego, California) |
| ABSTRACT | Heterocyclic compounds are described that are lysophosphatidic acid receptor ligands that are useful in the treatment of lysophosphatidic acid receptor-dependent diseases and conditions. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 18/015289 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) Heterocyclic Compounds C07D 231/38 (20130101) C07D 231/52 (20130101) C07D 233/88 (20130101) C07D 239/42 (20130101) C07D 261/14 (20130101) Original (OR) Class C07D 263/48 (20130101) C07D 401/04 (20130101) C07D 413/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286955 | Cohen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York); Tri-Institutional Therapeutics Discovery Institute, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David E. Cohen (New York, New York); Christopher Krumm (New York, New York); John Ginn (New York, New York) |
| ABSTRACT | The present disclosure relates to compounds that inhibit Them1. The disclosure further relates to methods of treating a metabolic disease in a subject in need thereof. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/116625 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/10 (20180101) Heterocyclic Compounds C07D 403/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286982 | Tepe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jetze J. Tepe (East Lansing, Michigan); Taylor J. Fiolek (DeWitt, Michigan); Katarina Keel (Lansing, Michigan) |
| ABSTRACT | Described herein are fluspirilene derivatives, methods for making such compounds, and the use of such compounds in the treatment of cancer, an inflammatory disease or condition or neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and ALS. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 18/041184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/438 (20130101) Heterocyclic Compounds C07D 213/22 (20130101) C07D 213/55 (20130101) C07D 213/79 (20130101) C07D 233/64 (20130101) C07D 265/36 (20130101) C07D 295/205 (20130101) C07D 471/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286995 | BANERJEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Souvik BANERJEE (Fort Smith, Arkansas); Shanshan DENG (Memphis, Tennessee); Wei LI (Germantown, Tennessee); K A Foyez MAHMUD (Chicago, Illinois); Duane D. MILLER (Collierville, Tennessee); Zhongzhi WU (Collierville, Tennessee); Rui WANG (Memphis, Tennessee); Tiffany SEAGROVES (Memphis, Tennessee); Raisa KRUTILINA (Memphis, Tennessee); Kelli HARTMANN (Memphis, Tennessee); Satyanarayana POCHAMPALLY (Memphis, Tennessee) |
| ABSTRACT | The invention encompasses novel dihydroquinoxalinone compounds with significantly improved water solubility and reduced toxicity to achieve higher therapeutic indexes and the treatment of cancer, virus infections, and inflammation using the same. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725465 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 403/14 (20130101) C07D 413/14 (20130101) C07D 471/04 (20130101) C07D 491/048 (20130101) Original (OR) Class C07D 498/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287028 | BISHOP et al. |
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| FUNDED BY |
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| APPLICANT(S) | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (Brentford, United Kingdom); FIMBRION THERAPEUTICS, INC. (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Joseph BISHOP (Research Triangle Park, North Carolina); Eugene L. Stewart (Collegeville, Pennsylvania); Katherine Louisa Widdowson (San Diego, California); James Walter Janetka (St. Louis, Missouri); Laurel Kathryn McGrane (St. Louis, Missouri) |
| ABSTRACT | Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD). |
| FILED | Friday, April 28, 2023 |
| APPL NO | 18/308842 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 7/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287029 | Hostetler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl Y. Hostetler (La Jolla, California); James Beadle (La Jolla, California); Nadejda Valiaeva (La Jolla, California); Robert T. Schooley (La Jolla, California) |
| ABSTRACT | Compounds, including antiviral prodrugs, and pharmaceutical formulations including the compounds, which may be orally bioavailable or formulated for intramuscular injection. Methods for producing compounds, such as antiviral prodrugs. Methods for treating coronavirus and other RNA virus infection in mammals. Methods of producing a drug triphosphate. |
| FILED | Saturday, July 24, 2021 |
| APPL NO | 18/006330 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 7/06 (20130101) Original (OR) Class C07H 9/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287038 | QI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ACCESS TO ADVANCED HEALTH INSTITUTE (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yizhi QI (Seattle, Washington); Christopher Bradford FOX (Sumner, Washington) |
| ABSTRACT | Substantially pure saponin extracts and orthogonal chromatographic methods for purification of saponin extracts are disclosed. The purified saponin extracts may include QS-21 and can have a purity of greater than 97%. The orthogonal chromatographic method uses reversed-phase (RP) chromatography followed by hydrophilic interaction liquid chromatography (HILIC) to generate substantially pure saponin extracts. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 18/020253 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 2039/55577 (20130101) Separation B01D 15/305 (20130101) B01D 15/325 (20130101) Steroids C07J 63/008 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/72 (20130101) G01N 30/8631 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287052 | BESIRLI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ONL Therapeutics, Inc. (Ann Arbor, Michigan); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cagri G. BESIRLI (Ann Arbor, Michigan); Alexander J. BRIDGES (Saline, Michigan); John K. FRESHLEY (Ann Arbor, Michigan); William A. HUNKE (Middletown, Delaware); Linda L. JOHNSON (Ann Arbor, Michigan); Francis X. SMITH (Salem, New Hampshire); Ethan SYLVAIN (Manchester, New Hampshire); David N. ZACKS (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas-or TRAIL-mediated apoptosis. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/159021 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class C07K 14/71 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287055 | Collins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Ser. (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Ser. (Bethesda, Maryland) |
| INVENTOR(S) | Peter Collins (Silver Spring, Maryland); Bo Liang (Boyds, Maryland); Shirin Munir (Potomac, Maryland); Anne Schaap Nutt (Austin, Texas); Ursula Buchholz (Silver Spring, Maryland); Natalie Mackow (East Setauket, New York); Peter Kwong (Washington, District of Columbia); Barney Graham (Smyrna, Georgia); Jason McLellan (Austin, Texas) |
| ABSTRACT | Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/162530 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/155 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287058 | Bondy-Denomy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Bondy-Denomy (Oakland, California); Benjamin Rauch (Oakland, California) |
| ABSTRACT | Cas9-inhibiting polypeptide compositions and methods are provided. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/954512 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/14 (20130101) A61K 35/28 (20130101) Peptides C07K 14/195 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287059 | Skaar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric P Skaar (Nashville, Tennessee); Erin Green (Nashville, Tennessee) |
| ABSTRACT | A composition, transgenic organism, and method of protecting against desiccation or heat are provided. The composition includes a DtpA protein or complement thereof and a heterologous biologic. The transgenic organism includes the nucleic acid sequence according to SEQ ID NO: 1. The method includes contacting a heterologous biologic or organism with a DtpA protein and/ or a complement thereof. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 18/006139 |
| CURRENT CPC | Peptides C07K 14/212 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/8201 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287066 | Llinas |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manuel Llinas (State College, Pennsylvania) |
| ABSTRACT | This document relates to sexual stage Plasmodium parasites. For example, Plasmodium parasites having (e.g., engineered to have) a regulatable AP2-G polypeptide that can be induced to enter the sexual stage are provided |
| FILED | Friday, October 15, 2021 |
| APPL NO | 18/018230 |
| CURRENT CPC | Peptides C07K 14/445 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/10 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/902 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287067 | Schlom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Jeffrey Schlom (Potomac, Maryland); Duane H. Hamilton (Washington, District of Columbia); Claudia M. Palena (Potomac, Maryland); Renee N. Donahue (Germantown, Maryland) |
| ABSTRACT | The invention provides human immunogenic epitopes of HEMO and HHLA2 human endogenous retroviruses (HERVs), which can be used as a peptide, polypeptide (protein), and/or in a vaccine or other composition for the prevention or therapy of cancer. The invention further provides a nucleic acid encoding the peptide or polypeptide (protein), a vector comprising the nucleic acid, a cell comprising the peptide, polypeptide (protein), nucleic acid, or vector, and compositions thereof. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/793753 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 35/17 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287090 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Feinstein Institutes for Medical Research (Manhasset, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haichao WANG (Edison, New Jersey); Kevin J. TRACEY (Old Greenwich, Connecticut); Jian Hua LI (New York, New York); Cassie ZHU (Great Neck, New York); Xiaoling QIANG (Hicksville, New York) |
| ABSTRACT | Provided SARS-CoV-2 receptor binding motif (RBM)-reactive monoclonal antibodies and fragments thereof, which inhibit the interaction between the spike protein RBM and human ACE2, as well as methods of use employing such antibodies and/or fragments. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 18/019548 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1018 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287140 | Woods et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elliot C. Woods (Burlingame, California); Han Xiao (East Palo Alto, California); Carolyn R. Bertozzi (Menlo Park, California); Melissa Gray (Stanford, California) |
| ABSTRACT | Provided are conjugates including a targeting moiety that binds to a cell surface molecule of a target cell and a target cell surface-editing enzyme. Also provided are compositions and kits that include the conjugates, as well as methods of using the conjugates. Methods of making conjugates are also provided. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/822638 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/32 (20130101) Original (OR) Class C07K 19/00 (20130101) C07K 2317/732 (20130101) C07K 2319/33 (20130101) C07K 2319/035 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287318 | Pope et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin D. Pope (Medford, Massachusetts); Kevin Kit Parker (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/116863 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/20 (20130101) C12M 25/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0653 (20130101) C12N 2533/30 (20130101) C12N 2533/90 (20130101) C12N 2535/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287357 | SKYLAR-SCOTT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Mark Andrew SKYLAR-SCOTT (Palo Alto, California); Jennifer A. LEWIS (Cambridge, Massachusetts); Jeremy Yuenchen HUANG (Cambridge, Massachusetts); Jingcheng LU (Somerville, Massachusetts); Tomoya DUENKI (Dachsen, Switzerland) |
| ABSTRACT | Described herein are methods of generating a programmable multicellular organoid and/or a 3D organ-specific tissue. Also, described are the programmable multicellular organoid and/or a 3D organ-specific tissue produced by the described methods. Also, described herein are in vitro methods of generating functional human tissue construct. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 18/012064 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7532 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 15/635 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) C12N 2800/90 (20130101) C12N 2800/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287362 | Whiteley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Whiteley (Boulder, Colorado); Hannah Ledvina (Boulder, Colorado); Kevin Corbett (San Diego, California); Qiaozhen Ye (San Diego, California); Yajie Gu (San Diego, California) |
| ABSTRACT | The invention describes the discovery and novel application of a bacterial ubiquitin transferase (Cap2). Specifically, the invention describes the novel activity of the enzyme Cap2 which is capable of creating a specific fusion between two proteins implementing a standalone catalytic mechanism to create the fusion. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/183815 |
| CURRENT CPC | Peptides C07K 16/10 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1007 (20130101) C12N 9/1077 (20130101) C12N 9/1241 (20130101) Original (OR) Class Enzymes C12Y 201/01 (20130101) C12Y 204/02038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287365 | ROBSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon C. ROBSON (Boston, Massachusetts); Elizabeth H. ZHONG (Boston, Massachusetts) |
| ABSTRACT | The present invention features bifunctional, soluble ecto-enzymes that are engineered to hydrolyze extracellular nucleotide triphosphates (e.g., ATP) to a nucleoside (e.g., adenosine), through the fusion of the ectodomains (ECD) of an ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) and a nucleotide monophosphatase (NMPAse), such as an ecto-5′ nucleotidase (eN), alkaline phosphatase (ALP), or an acid phosphatase (AP). Also described are methods of use thereof, e.g. for limiting and decreasing inflammation and sequelae. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 18/020342 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/46 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) Original (OR) Class C12N 9/16 (20130101) Enzymes C12Y 301/03005 (20130101) C12Y 306/01005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287370 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Jonathan Leo Schmid-Burgk (Cambridge, Massachusetts); Linyi Gao (Cambridge, Massachusetts); David Li (Cambridge, Massachusetts) |
| ABSTRACT | A method of identifying and characterizing novel Cas protein and guide RNAs with desired activity and specificity. The disclosure further comprises compositions and systems comprising engineered Cas protein and guide RNAs with desired activity and specificity. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/910497 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2310/315 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287371 | MARRAFFINI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luciano MARRAFFINI (Brooklyn, New York); Jakob ROSTOL (New York, New York) |
| ABSTRACT | Provided is an isolated or recombinantly expressed protein comprising the sequence of SEQ ID NO: 1 (CARD1), or an amino acid sequence that is at least 90% identical to the sequence of CARD1. Methods for producing and isolating the CARD1 protein are provided. Also provided are methods that include using CARD1, Cas1O and RNA obtained from a biological sample, and a guide RNA targeted to an RNA polynucleotide that may be in the biological sample, and determining whether or not the CARD1 cleaves a reporter ssDNA or reporter ssRNA that is added to the sample, to determine the presence or absence of the RNA polynucleotide. Kits for use in the assay are also provided. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 18/006251 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287373 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); University of Tokyo (Tokyo, Japan) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); University of Tokyo (Tokyo, Japan) |
| INVENTOR(S) | Feng ZHANG (Cambridge, Massachusetts); Winston YAN (Cambridge, Massachusetts); Osamu NUREKI (Tokyo, Japan); Kaijie ZHENG (Cambridge, Massachusetts); Le CONG (Cambridge, Massachusetts); Hiroshi NISHIMASU (Tokyo, Japan); Fei RAN (Cambridge, Massachusetts); Yinqing LI (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRJSPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CR.ISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/101867 |
| CURRENT CPC | Peptides C07K 2299/00 (20130101) C07K 2319/09 (20130101) C07K 2319/20 (20130101) C07K 2319/70 (20130101) C07K 2319/095 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) G16B 15/20 (20190201) G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287392 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William H. Robinson (Palo Alto, California); Yann Chong Tan (Palo Alto, California); Jeremy Sokolove (Mountain View, California) |
| ABSTRACT | Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herien are compositions and methods for expressing and screening molecules of interest. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392848 |
| CURRENT CPC | Peptides C07K 16/00 (20130101) C07K 16/1242 (20130101) C07K 16/1271 (20130101) C07K 2317/21 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 2458/10 (20130101) G01N 2500/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287397 | Shoura et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Massa Shoura (Stanford, California); Andrew Z. Fire (Stanford, California); Stephen Levene (Richardson, Texas) |
| ABSTRACT | Compositions and methods are provided for detection of dynamic loci in a genome. The methods may utilize microfluidic platforms and functionalized polymer matrices to allow determination of mechanisms of cell-type-specific, programmed genomic heterogeneity. |
| FILED | Monday, April 10, 2023 |
| APPL NO | 18/298202 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287402 | SASSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); MEDICAL RESEARCH COUNCIL, AS PART OF UNITED KINGDOM RESEARCH AND INNOVATION (Swindon, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ariel Ben SASSON (Seattle, Washington); David BAKER (Seattle, Washington); William SHEFFLER (Seattle, Washington); Hannele RUOHOLA-BAKER (Seattle, Washington); Logeshwaran SOMASUNDARM (Seattle, Washington); Emmanuel DERIVERY (Swindon, United Kingdom); Joseph WATSON (Swindon, United Kingdom) |
| ABSTRACT | The disclosure provides two-dimensional protein structures including first and second polypeptides that are different, each form homo-oligomers, and interact to form a rigid interface, polypeptide components of such two-dimensional protein structures, and uses thereof. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 18/040684 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287404 | NAKAI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroyuki NAKAI (Portland, Oregon); Samuel HUANG (Portland, Oregon); Kei ADACHI (Portland, Oregon) |
| ABSTRACT | Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160796 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/11 (20130101) C12N 2320/33 (20130101) C12N 2750/14123 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287405 | NAKAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroyuki NAKAI (Portland, Oregon); Samuel HUANG (Portland, Oregon); Kei ADACHI (Portland, Oregon) |
| ABSTRACT | Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160804 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/11 (20130101) C12N 2320/33 (20130101) C12N 2750/14123 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287411 | Fu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiang-Dong Fu (La Jolla, California); Yuanchao Xue (La Jolla, California) |
| ABSTRACT | The invention provides compositions and in vivo, ex vivo and in vitro methods for trans-differentiation of or re-programming mammalian cells to functional neurons. In particular, the invention provides methods for engineering non-neuronal cells into neurons, including fully functional human neuronal cells, and methods for engineering non-neuronal cells into neurons, e.g., fully functional human neuronal cells, in the brain to treat a neurodegenerative disease. In alternative embodiments, the invention provides compositions comprising re-differentiated or re-programmed mammalian cells, such as human cells, of the invention. The invention also provides compositions and methods for direct reprogramming of cells to a second phenotype or differentiated phenotype, such as a neuron, including a fully functional human neuronal cell. The invention also provides formulations, products of manufacture, implants, artificial organs or tissues, or kits, comprising a trans-differentiated or re-programmed cell of the invention, e.g., a fully functional human neuronal cell. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/938008 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 5/0623 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/531 (20130101) C12N 2320/30 (20130101) C12N 2501/15 (20130101) C12N 2501/20 (20130101) C12N 2501/24 (20130101) C12N 2501/60 (20130101) C12N 2501/998 (20130101) C12N 2501/2318 (20130101) C12N 2506/1307 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287427 | Rosenzweig et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony Rosenzweig (Newton, Massachusetts); Haobo Li (Allston, Massachusetts) |
| ABSTRACT | The disclosure provides compositions comprising an inhibitory nucleic acid targeting IncExACTI, and methods of use thereof to improve cardiac function in a subject in need thereof. Specifically, the disclosure provides a cardiac long noncoding RNA (IncRNA), referred as IncExACT 1 (SEQ ID NO: 1), and inhibitory nucleic acids targeting IncExACT 1 for reducing expression of IncExACT 1 and/or Dachsous cadherin-related 2 (DCHS2) in a cell, e.g., a cell in a subject for improving cardiac function in a subject, wherein the subject has pathological cardiac hypertrophy and/or heart failure. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 18/018478 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/1136 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/531 (20130101) C12N 2310/3515 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287438 | Joshi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHEASTERN UNIVERSITY (Boston, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neel S. Joshi (Somerville, Massachusetts); IIia Gelfat (Cambridge, Massachusetts); Anton KAN (Denton, Texas) |
| ABSTRACT | Disclosed are methods for producing genetically modified bacteria, comprising introducing into said bacteria at least one engineered cryptic plasmid comprising a heterologous nucleic acid, wherein the heterologous nucleic acid comprises a nucleic acid sequence encoding a recombinant protein and a polypeptide secretion system for directing the recombinant protein to the outer membrane for secretion, wherein the bacteria do not comprise any native cryptic plasmids. |
| FILED | Wednesday, September 15, 2021 |
| APPL NO | 18/026439 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/62 (20130101) C12N 15/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287441 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Abudayyeh (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Lukas Villiger (Cambridge, Massachusetts); Kaiyi Jiang (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides complexes for prime editing comprising an RNA-guided nuclease, a fusion protein comprising a reverse transcriptase domain linked to a nucleic acid binding protein, and a guide RNA (gRNA) comprising at least one protein-recruiting stem-loop nucleic acid sequence, wherein the protein-recruiting stem-loop nucleic acid sequence binds to the nucleic acid binding protein. Also provided are systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE) with integration enzymes paired with the prime editing complex. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067214 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/8213 (20130101) Original (OR) Class C12N 2770/32322 (20130101) Enzymes C12Y 207/07049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287444 | Slade et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arcadia Biosciences, Inc. (Davis, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ann J. Slade (Bellevue, Washington); Dayna L. Loeffler (Seattle, Washington); Aaron M. Holm (Shoreline, Washington); Jessica C. Mullenberg (Lynnwood, Washington) |
| ABSTRACT | A series of independent human-induced non-transgenic mutations found at one or more of the SBEII genes of wheat; wheat plants having these mutations in one or more of their SBEII genes; and a method of creating and finding similar and/or additional mutations of SBEII by screening pooled and/or individual wheat plants. The seeds and flour from the wheat plants of the present invention exhibit an increase in amylose and resistant starch without having the inclusion of foreign nucleic acids in their genomes. Additionally, the wheat plants of the present invention exhibit altered SBEII activity without having the inclusion of foreign nucleic acids in their genomes. |
| FILED | Monday, April 10, 2023 |
| APPL NO | 18/298041 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/4678 (20180501) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/107 (20130101) C12N 15/8245 (20130101) Original (OR) Class Enzymes C12Y 204/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287452 | Vandenberghe et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luk Vandenberghe (Weston, Massachusetts); Guangping Gao (Westborough, Massachusetts); James M. Wilson (Philadelphia, Pennsylvania) |
| ABSTRACT | A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 18/054786 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0091 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) C12N 2750/14143 (20130101) C12N 2750/14152 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287457 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); CORNELL UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Zhang (Ann Arbor, Michigan); Ailong Ke (Ithaca, New York); Ryan Krueger (Ann Arbor, Michigan); Zhonggang Hou (Ann Arbor, Michigan) |
| ABSTRACT | The disclosure provides a method of altering a DNA sequence, which method comprises the use of a type I-C CRISPR-Cas system based on Neisseria lactamica. The system involves a combination of two or more Neisseria lactamica proteins selected from Cas3, Cas5, Cas8c, and Cas7 and a synthetic guide RNA sequence. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 18/000676 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/70 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287459 | Wiles et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| INVENTOR(S) | Michael V. Wiles (Bar Harbor, Maine); Benjamin E. Low (Bar Harbor, Maine); Vishnu Hosur (Bar Harbor, Maine) |
| ABSTRACT | The present disclosure provides methods and compositions for high frequency, targeted mammalian transgenesis using, for example, a two-step, two-stage process that enables integrating anywhere in the mammalian genome large pieces of nucleic acid in single generation. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 18/019999 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0604 (20130101) C12N 9/22 (20130101) C12N 9/485 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/8509 (20130101) C12N 2310/20 (20170501) C12N 2510/00 (20130101) C12N 2800/30 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 304/17023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287473 | Swami et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Swami (Charlottesville, Virginia); Cirle Alcantrara Warren (Waynesboro, Virginia); John Hudson Moore, II (Waynesboro, Virginia); Carlos Honrado (Macedo Cavaleiros, Portugal); Armita Salahi (Charlottesville, Virginia) |
| ABSTRACT | A method for quantifying bacterial spore germination can include creating an ex vivo assay including bacteria spores and a homogenized stool sample. The ex vivo assay can be loaded into a microfluidic chip. Vegetative bacteria and the bacteria spores can be detected by sampling the mixture in the microfluidic chip using impedance cytometry to assess disruption of host microbiota. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 18/006236 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287499 | GONSKY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca GONSKY (Los Angeles, California); Stephan R. TARGAN (Santa Monica, California) |
| ABSTRACT | Described herein are methods, systems, compositions, and kits useful for identifying patients as having a high likelihood of recurrence of a disease or condition affecting the gastrointestinal tract following surgical treatment of the disease or condition. The present disclosure relates to methods and systems for identifying and stratifying patients, suitable for treatment with a modulator of RNASET2, as described herein. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 18/008150 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287507 | Jiang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Jiang (Ellicott City, Maryland) |
| ABSTRACT | The present invention provides a method of predicting whether a pulmonary nodule in a subject is benign or non-small cell lung cancer, comprising obtaining the results of an assay that measures an expression level of miR205-5p in a plasma sample from the subject; obtaining the results of an assay that measures an expression level of miR126 in a plasma sample from the subject; obtaining the results of an assay that provides a size of the pulmonary nodule in the subject; and calculating a probability value based on the combination of the expression levels of miR205-5p and miR126, and the size of the pulmonary nodule, wherein if the probability value exceeds a specified threshold, the pulmonary nodule is predicted as non-small cell lung cancer. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992668 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2525/207 (20130101) C12Q 2561/113 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287510 | WU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Catherine J. WU (Boston, Massachusetts); Gad GETZ (Boston, Massachusetts); Binyamin A. KNISBACHER (Cambridge, Massachusetts); Ziao LIN (Cambridge, Massachusetts); Cynthia K. HAHN (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Catherine J. WU (Boston, Massachusetts); Gad GETZ (Boston, Massachusetts); Binyamin A. KNISBACHER (Cambridge, Massachusetts); Ziao LIN (Cambridge, Massachusetts); Cynthia K. HAHN (Boston, Massachusetts) |
| ABSTRACT | As described below, the present invention features compositions, panels of biomarkers, and methods for characterizing chronic lymphocytic leukemia (CLL) for prognosis and selection of a subject for a treatment and/or inclusion in a clinical trial. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 18/020587 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288300 | Rozhok et al. |
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| FUNDED BY |
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| APPLICANT(S) | NanoCytomics, LLC (Evanston, Illinois); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergey Rozhok (Evanston, Illinois); Justin R. Derbas (Evanston, Illinois); Jarema Czarnecki (Evanston, Illinois); Hariharan Subramanian (Evanston, Illinois) |
| ABSTRACT | Automated cell staining systems and methods are disclosed herein. In particular, the staining systems disclosed herein provide low-volume, automated bench top staining systems for staining biological samples contained on a cytological slide. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958718 |
| CURRENT CPC | Apparatus for Applying Fluent Materials to Surfaces, in General B05C 3/02 (20130101) B05C 3/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 1/30 (20130101) G01N 1/312 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288406 | Lewis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Lewis (La Jolla, California); Wan-Tien Chiang (La Jolla, California); Chenguang Liang (La Jolla, California); James T. Sorrentino (La Jolla, California) |
| ABSTRACT | A transformative method to profile the glycome in individual cells by leveraging computational biology tools with lectin or similar profiling technologies. Robust and accurate reconstruction glycomes with high-resolution glycan structure information for biological samples, including at the single cell level. Tools such as single-clone analysis andjoint-clone analysis, which may be used to assist researchers in analyzing single cell glycoprofiled samples, which identify how glycosylation variation across cells impact the cellular phenotypes. Single cell glycoprofiling using lectins is practically implemented to provide high resolution of the glycan structure information. Glycan profiling techniques having a wide range of biological applications from embryonic development to cancer and infectious disease due to high throughput, low cost, and robust reliability. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 18/007397 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) Original (OR) Class G01N 33/54326 (20130101) G01N 2333/4724 (20130101) G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288414 | Casanova |
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| FUNDED BY |
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| APPLICANT(S) | THE ROCKEFELLER UNIVERSITY (New York, New York); NSERM(Institut National de la Santé la Recherche Médicale) (Paris, France); Assistance Publique-Hôptiaux de Paris (APHP) (Paris, France); Université Paris Cité (Paris, France); Fondation Imagine (Paris, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jean-Laurent Casanova (New York, New York) |
| ABSTRACT | The present invention provides methods, assays and kits for assessment of patients positive for SARS-CoV-2 infection and methods of diagnosis and treatment of COVID-19 disease and for assessment and evaluation of individuals prior to vaccination with live attenuated virus vaccines, particularly including yellow fever vaccines and COVID-19 vaccines, to assess risk for vaccine-associated disease and adverse events, and for evaluation, treatment and management of patients who develop vaccine-associated disease. The invention provides methods and assays for identification and characterization of inborn errors of type I interferon immunity and also auto-antibodies against Type I IFNs that are associated with severe COVID-19 disease or that are correlated and linked with vaccine-associated disease. The invention further provides methods of diagnosing and determining altered response to or susceptibility to SARS-CoV-2 infection or to live attenuated virus vaccines and for applicable and suitable treatment of COVID-19 disease or vaccine-associated disease. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 18/017249 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 2333/555 (20130101) G01N 2800/24 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288424 | Kislinger et al. |
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| FUNDED BY |
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| APPLICANT(S) | University Health Network (Toronto, Canada); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Kislinger (Toronto, Canada); Paul C. Boutros (Toronto, Canada); Amanda Khoo (Toronto, Canada); Yiyang Liu (Toronto, Canada) |
| ABSTRACT | The present disclosure provides methods of prognosis of prostate cancer using mpMRl visibility biomarkers selected from SRD5A2, GNA11, CAPNS1, NCDN, WDR5 and/or LDHB. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/116963 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57434 (20130101) Original (OR) Class G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288435 | Basmajian et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baebies, Inc. (Durham, North Carolina) |
| ASSIGNEE(S) | Baebies, Inc. (Durham, North Carolina) |
| INVENTOR(S) | Michael A. Basmajian (Durham, North Carolina); Michael Boso (Durham, North Carolina); Jennifer Elderbroom (Durham, North Carolina) |
| ABSTRACT | The invention relates generally to biochemical assays and more particularly to digital microfluidics multi-dynamic range parallel biochemical assays. The invention provides methods that enable improved precision and linearity for digital microfluidics analyses (i.e., analyses performed on a droplet actuator using droplet operations), including for example, assays related to measuring analytes in a biological sample. Examples of assays that may be performed using a method of the invention include measuring analytes in blood, including analytes from blood components, such as analytes present in plasma. The invention provides a digital microfluidics device (or cartridge) and methods for performing a biochemical assay using the microfluidics device to measure an analyte in a sample. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/962898 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502792 (20130101) B01L 2400/0427 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/728 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288558 | KONOFAGOU et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Elisa E. KONOFAGOU (New York, New York); Md Murad Hossain (New York, New York) |
| ABSTRACT | The present subject matter relates to techniques for single transducer harmonic motion imaging. The disclosed system can include a transducer. The transducer can be configured to generate an amplitude-modulated acoustic radiation force (AM-ARF) by sinusoidally modulating a duration of an excitation pulse of an acoustic radiation force, induce a harmonic motion on a target tissue using the AM-ARF, and simultaneously track the harmonic motion by collecting a tracking pulse. The tracking pulse can be interleaved between the excitation pulse. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/064021 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/629 (20130101) G01S 7/52036 (20130101) G01S 7/52095 (20130101) G01S 15/102 (20130101) G01S 15/8911 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288586 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Xin LI (, None); Lars FURENLID (, None) |
| ABSTRACT | The present invention provides a method of calibrating gamma-ray and photon counting detectors, including, but not limited to, monolithic crystal detectors. The method of the present invention is based on the observation that measurement of fan beam datasets allows the synthesis of collimated beam data to derive MDRFs by use of an algorithm that finds the common or intersecting data subsets of two or more orthogonal calibration datasets. This makes the calibration process very efficient while still allowing the full benefits of maximum-likelihood event-parameter estimation that incorporates the statistical nature of the light sensor measurements. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068882 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/202 (20130101) G01T 1/2018 (20130101) G01T 1/2964 (20130101) G01T 7/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230289972 | Contijoch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francisco Contijoch (San Diego, California); Zhennong Chen (San Diego, California); Davis Vigneault (Palo Alto, California); Marzia Rigolli (La Jolla, California) |
| ABSTRACT | Devices, systems, and methods for automated segmentation and slicing of cardiac computed tomography (CT) images are described. An example method includes receiving a first plurality of input image frames associated with a cardiac CT operation, each of the first plurality of input image frames comprising a representation of two or more chambers of a heart, and performing, using a convolutional neural network, a segmentation operation and a slicing operation on each of the first plurality of input image frames to generate each of a plurality of output image frames comprising results of the segmentation operation and the slicing operation, wherein the segmentation operation comprises identifying volumes of each of the two or more chambers of the heart based on blood volumes, wherein the slicing operation comprises identifying one or more features of the heart in at least one predefined plane in a coordinate system associated with the cardiac CT operation. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 18/006145 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) Original (OR) Class G06T 7/0012 (20130101) G06T 7/174 (20170101) G06T 2207/10081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290433 | Buckler et al. |
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| FUNDED BY |
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| APPLICANT(S) | Elucid Bioimaging Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. Buckler (Boston, Massachusetts); Ljubica Matic (Solna, Sweden); Ulf Hedin (Ronninge, Sweden) |
| ABSTRACT | Atherosclerotic plaque phenotyping by image data analysis, e.g., using conventional computed tomography angiography (CTA) or other imaging modalities can elucidate the molecular signature of atherosclerotic lesions on a per-patient basis. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/693229 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290434 | Castro et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Egbert Castro (New Haven, Connecticut); Smita Krishnaswamy (Madison, Connecticut); Abhinav Godavarthi (Plano, Texas); Julian Rubinfien (New York, New York) |
| ABSTRACT | A system for identifying biomolecules with a desired property comprises a computer-readable medium with instructions stored thereon, which when executed by a processor perform steps comprising collecting a quantity of biomolecular data, transforming the biomolecular data from a sequence space to a latent space representation of the data, compressing the latent space representation using a pooling mechanism, compressing the coarse representation of the biomolecular data using an informational bottleneck, calculating a fitness factor of each data element in the low-dimensional representation of the biomolecular data, choosing a point from within the low-dimensional representation of the biomolecular data, calculating a set of gradients of the fitness factor, selecting an adjacent point having the highest gradient and setting it as the first point, then repeating the gradient calculating step until the fitness factor reaches a convergence point. A method for identifying biomolecules with a desired property is also disclosed. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061272 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290467 | NATARAJAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Yale University (New Haven, Connecticut); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Yale University (New Haven, Connecticut); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Pradeep NATARAJAN (Boston, Massachusetts); Giulio GENOVESE (Cambridge, Massachusetts); Seyedeh Maryam ZEKAVAT (New Haven, Connecticut); Mitchell J. MACHIELA (Bethesda, Maryland); Shu-Hong LIN (Bethesda, Maryland) |
| ABSTRACT | The invention features methods that are useful for treatment of a patient at increased risk for infection and for selecting a patient for treatment for an infection. In various embodiments, the infection is coronavirus disease 2019 (COVID-19), sepsis, or other respiratory infections. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/121496 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 20/10 (20180101) Original (OR) Class G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230284851 | Krasnobaev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vivonics, Inc. (Bedford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonid Krasnobaev (Framingham, Massachusetts) |
| ABSTRACT | A particle collection system and method including a collection inlet aimable at a surface from which particles are to be collected, and a rotatable fixture including at least a pair of nozzles about the collection inlet also aimable at the surface and fluidly connected to a source of compressed fluid in order to dislodge particles from the surface. The rotatable fixture is rotated to generate, as the nozzles rotate about the collection inlet, a vortex dislodging and picking up particles on the surface, entraining the particles, and carrying the particles to the collection inlet. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/174841 |
| CURRENT CPC | Domestic Washing or Cleaning; Suction Cleaners in General A47L 9/0416 (20130101) A47L 9/1666 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230284939 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles P. Lin (Arlington, Massachusetts); Hari Prasad Paudel (Boston, Massachusetts) |
| ABSTRACT | Systems, methods, and apparatus for differential phase contrast microscopy by transobjective differential epi-detection of forward scattered light are provided. In some embodiments, a microscope objective comprises: a housing with mounting threads at a second end; optical components defining an optical axis, comprising: an objective lens mounted at a first end, configured to collect light from a sample placed in a field of view, the plurality of optical components create a pupil plane at a first distance along the optical axis at which rays having the same angle of incidence on the objective lens converge at the same radial distance from the optical axis; a photodetector within the housing offset from the optical axis at a second distance along the optical axis; and another photodetector within the housing at second distance along the optical axis and offset from the optical axis in the opposite direction from the first photodetector. |
| FILED | Wednesday, May 17, 2023 |
| APPL NO | 18/319163 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0068 (20130101) A61B 5/1455 (20130101) A61B 5/14535 (20130101) Original (OR) Class A61B 2562/0233 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1436 (20130101) G01N 15/1468 (20130101) G01N 2015/144 (20130101) G01N 2015/1006 (20130101) Optical Elements, Systems, or Apparatus G02B 21/002 (20130101) G02B 21/008 (20130101) G02B 21/14 (20130101) G02B 21/0048 (20130101) G02B 21/0056 (20130101) G02B 21/0068 (20130101) G02B 21/086 (20130101) G02B 21/365 (20130101) G02B 26/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285305 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter X. Ma (Ann Arbor, Michigan); Ming Dang (Maple Grove, Minnesota); Laurie K. McCauley (Ann Arbor, Michigan) |
| ABSTRACT | In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed. |
| FILED | Saturday, May 20, 2023 |
| APPL NO | 18/199939 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/204 (20130101) A61K 9/205 (20130101) A61K 9/2031 (20130101) Original (OR) Class A61K 9/5031 (20130101) A61K 9/7007 (20130101) A61K 38/29 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285401 | Zuo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| ASSIGNEE(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Zhuo Li (Omaha, Nebraska); Marisa Laura Zallocchi (Omaha, Nebraska) |
| ABSTRACT | In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. Momelotinib and Fedratinib exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice when administered prophylactically. In one aspect, Momelotinib or Fedratinib can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/084033 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/5377 (20130101) Original (OR) Class A61K 33/243 (20190101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285418 | Zuo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| ASSIGNEE(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Pezhman Salehi Dermanaki (Elkhorn, Nebraska); Marisa Laura Zallocchi (Omaha, Nebraska); Sarath Vijayakumar (Omaha, Nebraska) |
| ABSTRACT | Acquired hearing loss due to chemotherapy or noise exposure is a major health problem, and Cisplatin chemotherapy often causes permanent hearing loss in cancer patients. However, there are no FDA-approved drugs for the treatment or prevention of Cisplatin- or noise-induced hearing loss. In one aspect, use of Niclosamide, Ingenol, and Elesclomol as an active agent to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/081951 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) A61K 31/165 (20130101) A61K 31/397 (20130101) A61K 31/609 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285439 | Clarke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael F. Clarke (Stanford, California); Robert W. Hsieh (Stanford, California) |
| ABSTRACT | The invention is directed to methods of treating TNBC in a patient by administering to the patient an agent that inhibits the expression or activity of cyclin-dependent kinase 19 (CDK19). In some embodiments, the agent may be a small molecule inhibitor, a polynucleotide (e.g., shRNA. siRNA), or a protein (e.g., an antibody). In some embodiments, the agent does not inhibit the activity or expression of CDK8. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/823028 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285539 | JOYCE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| INVENTOR(S) | Michael Gordon JOYCE (Silver Spring, Maryland); Kayvon MODJARRAD (Bethesda, Maryland) |
| ABSTRACT | The present disclosure relates to the field of vaccines and binding molecules, as well as preparations and methods of their use in the treatment and/or prevention of disease. Described are vaccines and binding molecules, compositions containing the same, and uses thereof for treating or preventing coronavirus infections, in particular, β-coronaviruses such as SARS- CoV-2, the causative agent of COVID-19, as well as SARS-CoV-1 and other coronaviruses. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/905614 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5169 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/55505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285543 | BOGDAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Paul BOGDAN (Los Angeles, California); Shahin NAZARIAN (Los Angeles, California); Zikun YANG (Los Angeles, California) |
| ABSTRACT | Computer systems and computer implemented methods are presented for designing and making vaccines to pathogens, particular viral pathogens. Vaccine compositions for COVID-19 are also disclosed, as well as method of using the same. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 18/016230 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285930 | Ramezani |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ODH IP CORP. (New York, New York) |
| ASSIGNEE(S) | ODH IP CORP. (New York, New York) |
| INVENTOR(S) | Madhi Ramezani (Rockville, Maryland) |
| ABSTRACT | Modular reactors comprising a chassis, reactor tubing and optionally a cover are disclosed. The chassis comprises a plurality of channels of different lengths into which a length of reactor tubing is placed to create the reactor portion of the flow reactor. |
| FILED | Monday, March 20, 2023 |
| APPL NO | 18/186474 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0073 (20130101) B01J 19/0093 (20130101) B01J 19/243 (20130101) B01J 19/248 (20130101) Original (OR) Class B01J 2219/00166 (20130101) B01J 2219/00894 (20130101) B01J 2219/00984 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286047 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Vinayak P. Dravid (Evanston, Illinois); Liban Jibril (Evanston, Illinois) |
| ABSTRACT | A method of forming a nanoparticle can include admixing an aqueous solution into an oil-phase to thereby form an emulsion of droplets of the aqueous solution in the oil phase, the aqueous solution comprising a nanostructure precursor and a polymer, adding a silane precursor and catalyst to form a silica shell around each of the droplets to nanoreactors; annealing at a first temperature below the decomposition temperature of the polymer to aggregate the nanostructure precursor within the nanoreactor; and annealing at a second temperature above the decomposition temperature of the polymer to convert the aggregated nanostructure precursor to the nanostructure and decompose the polymer. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/118031 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/16 (20220101) B22F 1/054 (20220101) B22F 9/26 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286102 | HARDY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); Fraunhofer USA (Plymouth, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); Fraunhofer USA (Plymouth, Michigan) |
| INVENTOR(S) | Aaron HARDY (East Lansing, Michigan); Timothy A. GROTJOHN (Okemos, Michigan); Edward K. DROWN (Haslett, Michigan); Michael BECKER (East Lansing, Michigan) |
| ABSTRACT | A polishing apparatus is provided. Another aspect pertains to a self-leveling polishing apparatus for smoothing diamonds. Yet another aspect of the present system uses a ball and swivel joint in a diamond polishing machine. A further aspect employs a polishing apparatus including a diamond-holder, an elongated arm using gravity to apply downward polishing pressure of the diamond workpiece against a polishing wheel, and a sweeping transmission to cause the holder to radially move across the rotating polishing wheel. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/922728 |
| CURRENT CPC | Machines, Devices, or Processes for Grinding or Polishing; Dressing or Conditioning of Abrading Surfaces; Feeding of Grinding, Polishing, or Lapping Agents B24B 9/161 (20130101) Original (OR) Class B24B 37/26 (20130101) B24B 37/105 (20130101) B24B 41/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286675 | Ward et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan M. Ward (Alexandria, Virginia); Bryan C. Brown (Silver Spring, Maryland); David F. Chicka (Vienna, Virginia); Nathaniel K. Ng (Washington, District of Columbia) |
| ABSTRACT | Systems and methods are provided for high fidelity long-duration autonomous spacecraft navigation relative to a planet's surface and measuring the dynamics of the planet. For a planet like Earth, embodiments of the present disclosure can be used to estimate the unpredictable components of Earth's orientation with respect to the inertial frame. Embodiments of the present disclosure further enable autonomous landmark navigation by providing systems and methods for satellites to autonomously recognize landmarks, using, for example, multiple computer vision approaches to recognize multiple types of landmarks. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/118720 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/244 (20190501) Original (OR) Class B64G 1/361 (20130101) B64G 1/365 (20130101) B64G 2001/247 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286677 | DENHAM |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Donald Wayne DENHAM (Redondo Beach, California) |
| ABSTRACT | An autonomous compliance controlled generic mooring station includes a pair of mooring systems connected to each other. The pair of mooring systems includes a pair of mooring interfaces, allowing the pair of mooring systems to change between a mooring state and a release state. One of the pair of mooring interfaces includes an electropermanent magnet and the other one of the pair of mooring interfaces includes a ferromagnetic plate. The electropermanent magnet and the ferromagnetic plate are configured to connect the pair of mooring systems together. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694579 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/646 (20130101) Original (OR) Class B64G 1/1078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286820 | Renner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julie Renner (Cleveland, Ohio); R. Mohan Sankaran (Cleveland, Ohio) |
| ABSTRACT | A method of ammonia synthesis is described that includes contacting a nitrogen gas-containing plasma with an aqueous solution, thereby forming ammonia from the nitrogen gas and water. The nitrogen gas-containing plasma is present in an electrochemical cell. The electrochemical cell includes a container including an acidic liquid electrolyte. The electrochemical cell also includes a source of nitrogen gas, a metal electrode at least partially immersed in the electrolyte, a metal tube electrode spaced apart from a surface of the electrolyte by a predetermined spacing. The electrochemical cell is configured to provide a plasma spanning the predetermined space from the metal tube electrode to contact the surface of the electrolyte when power is applied to the metal tube electrode. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/321404 |
| CURRENT CPC | Ammonia; Cyanogen; Compounds Thereof C01C 1/0494 (20130101) Original (OR) Class Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 11/02 (20130101) C25B 11/061 (20210101) C25B 11/081 (20210101) C25B 15/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286871 | Villalobos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guillermo R. Villalobos (Springfield, Virginia); Rafael R. Gattass (Washington, District of Columbia); Michael Hunt (Alexandria, Virginia); Shyam S. Bayya (Ashburn, Virginia); Bryan Sadowski (Falls Church, Virginia); Robert Miklos (La Plata, Maryland); Frederic H. Kung (Alexandria, Virginia); Woohong Kim (Lorton, Virginia); L. Brandon Shaw (Woodbridge, Virginia); Jasbinder S. Sanghera (Ashburn, Virginia); Antti Makinen (Alexandria, Virginia) |
| ABSTRACT | Disclosed is a method of flash sintering a sample composed of ceramic particles by providing laser energy to change the electrical properties of the ceramic material. The processes and systems disclosed herein do not require large heating equipment like a furnace allowing for a portable system of repairing ceramic materials in the field. |
| FILED | Thursday, March 23, 2023 |
| APPL NO | 18/125181 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) Original (OR) Class C04B 35/111 (20130101) C04B 35/563 (20130101) C04B 2235/608 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286964 | Palmese et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Giuseppe Raffaello Palmese (Hainesport, New Jersey); Mengwen Yu (Philadelphia, Pennsylvania); John Joseph La Scala (Wilmington, Delaware) |
| ASSIGNEE(S) | DREXEL UNIVERISTY (Philadelphia, Pennsylvania); The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Giuseppe Raffaello Palmese (Hainesport, New Jersey); Mengwen Yu (Philadelphia, Pennsylvania); John Joseph La Scala (Wilmington, Delaware) |
| ABSTRACT | A series of bio-based benzoxazine monomers were developed. These benzoxazine monomers are liquid at room temperature with good processability due to their low viscosities at or near room temperature and their relatively low polymerization temperatures. Cured materials made from these bio-based benzoxazines have excellent thermal and mechanical properties. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 18/005704 |
| CURRENT CPC | Heterocyclic Compounds C07D 413/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287065 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fuzhong Zhang (St. Louis, Missouri); Christopher H. Bowen (St. Louis, Missouri); Bin Dai (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to systems and methods for synthesizing a spidroin. In some embodiments, the methods comprise synthesizing a monomer in vivo in a heterologous host, the monomer comprising an N-terminus IntC domain and a C-terminus IntN domain, and post-translationally polymerizing the synthesized monomer via in vitro split-intein mediated polymerization. |
| FILED | Thursday, April 27, 2023 |
| APPL NO | 18/308301 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/05 (20190201) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2089/00 (20130101) B29K 2995/0088 (20130101) Peptides C07K 14/43518 (20130101) Original (OR) Class C07K 2319/21 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/70 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 1/02 (20130101) D01D 5/06 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287067 | Schlom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Jeffrey Schlom (Potomac, Maryland); Duane H. Hamilton (Washington, District of Columbia); Claudia M. Palena (Potomac, Maryland); Renee N. Donahue (Germantown, Maryland) |
| ABSTRACT | The invention provides human immunogenic epitopes of HEMO and HHLA2 human endogenous retroviruses (HERVs), which can be used as a peptide, polypeptide (protein), and/or in a vaccine or other composition for the prevention or therapy of cancer. The invention further provides a nucleic acid encoding the peptide or polypeptide (protein), a vector comprising the nucleic acid, a cell comprising the peptide, polypeptide (protein), nucleic acid, or vector, and compositions thereof. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/793753 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 35/17 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287388 | FUNKNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CureVac Manufacturing GmbH (Tübingen, Germany) |
| ASSIGNEE(S) | CureVac Manufacturing GmbH (Tübingen, Germany) |
| INVENTOR(S) | Andreas FUNKNER (Tübingen, Germany); Stefanie DORNER (Tübingen, Germany); Stefanie SEWING (Tübingen, Germany); Johannes KAMM (Tübingen, Germany); Norbert BROGHAMMER (Tübingen, Germany); Thomas KETTERER (Gomaringen, Germany); Thorsten MUTZKE (Reutlingen, Germany) |
| ABSTRACT | The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF). |
| FILED | Tuesday, May 16, 2023 |
| APPL NO | 18/198258 |
| CURRENT CPC | Separation B01D 61/145 (20130101) B01D 71/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1017 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/02 (20130101) G01N 2030/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287466 | Ding et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH (GAINESVILLE, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF FLORIDA RESEARCH (GAINESVILLE, Florida) |
| INVENTOR(S) | Yousong Ding (Gainesville, Florida); Ran Zuo (Gainesville, Florida) |
| ABSTRACT | The disclosure relates, in some aspects, to compositions and methods useful for production of nitrated aromatic molecules. The disclosure is based, in part, on whole cell systems expressing artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes. In some aspects, the disclosure relates to methods of producing nitrated aromatic molecules in whole cell systems having artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152329 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/0042 (20130101) C12N 9/0075 (20130101) C12N 15/62 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/227 (20130101) Original (OR) Class Enzymes C12Y 101/9901 (20130101) C12Y 106/02004 (20130101) C12Y 114/13039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287473 | Swami et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Swami (Charlottesville, Virginia); Cirle Alcantrara Warren (Waynesboro, Virginia); John Hudson Moore, II (Waynesboro, Virginia); Carlos Honrado (Macedo Cavaleiros, Portugal); Armita Salahi (Charlottesville, Virginia) |
| ABSTRACT | A method for quantifying bacterial spore germination can include creating an ex vivo assay including bacteria spores and a homogenized stool sample. The ex vivo assay can be loaded into a microfluidic chip. Vegetative bacteria and the bacteria spores can be detected by sampling the mixture in the microfluidic chip using impedance cytometry to assess disruption of host microbiota. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 18/006236 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287487 | Ricke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology. (Cambridge, Massachusetts) |
| INVENTOR(S) | Darrell Orlyn Ricke (Winchester, Massachusetts); James Harper (Jamaica Plain, Massachusetts); Brian S. Helfer (Brookline, Massachusetts); Joseph Isaacson (Latham, New York); Adam M. Michaleas (Hudson, New Hampshire); Martha S. Petrovick (Barre, Massachusetts); Eric Schwoebel (Woburn, Massachusetts); Anna Shcherbina (East Palo Alto, California); Philip Fremont-Smith (Newmarket, New Hampshire); James G Watkins (Sutton, Massachusetts); Edward C. Wack (Waltham, Massachusetts) |
| ABSTRACT | The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components. The methods of the disclosure do not require any prior knowledge of individual DNA profiles or contributors to the complex DNA mixtures. Moreover, the methods of the disclosure may use any SNP panel, including those panels already existing and those panels specifically designed to maximize performance characteristics of the methods described herein. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/104727 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 40/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287520 | Larson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Marilynn A. Larson (Lincoln, Nebraska); James C. Baldwin (Huber Heights, Ohio); Michael P. Dempsey (Bowie, Maryland) |
| ABSTRACT | A method of detecting a presence of Francisella tularensis (F. tularensis). The method includes amplifying a first nucleic acid from said specimen using a first plurality of primers, said first plurality of primers comprising SEQ ID NO 4 and SEQ ID NO 5. When the first nucleic acid is detected, then the presence of F. tularensis is determined. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/152127 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287557 | Hu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yimin Hu (Clarksville, Maryland); Feng Niu (Arlington Heights, Illinois); Wei Lu (Great Falls, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yimin Hu (Clarksville, Maryland); Feng Niu (Arlington Heights, Illinois); Wei Lu (Great Falls, Virginia) |
| ABSTRACT | This invention provides a process or fabrication method of forming broadband anti-reflective (AR) coating over the mid-IR fluoride fiber for high power laser applications in mid-IR wavelength range. The AR coating consists of multiple-pair Lithium fluoride (LiF) and Al2O3, and was deposited by electron beam physical vapor deposition with an iron assistant source at low temperature (<60° C.). A thin encapsulation layer of Al2O3 was applied over the AR coating by atomic layer deposition technology. The measurements show the coating has a reflectivity of <1-1.5% in the range of 1.5-5.5 μm. The laser induced damage threshold (LIDT) test shows the damage threshold is greater than 8.9 MW/cm2 with no sign of any damage on the coating exposed to atmosphere. The durability and environmental tests of the AR coating with PVD coated encapsulation layer show good humidity resistance in open air and no degradation of film quality and optical performance are observed. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691537 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/30 (20130101) Original (OR) Class C23C 14/081 (20130101) C23C 14/083 (20130101) C23C 28/3455 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287836 | Thorup et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessie Thorup (Malden, Massachusetts); Christopher David King (Salem, Massachusetts) |
| ABSTRACT | Control schemes for controlling a gas turbine engine in response to disturbances associated with a load mechanically coupled with the gas turbine engine are provided. In one aspect, a gas turbine engine mechanically coupled with a load has a controller that includes executable control logic. The control logic includes a feedforward module, an aggressive control module, and a power turbine governor module. By executing the modules, the controller seeks to maintain a constant power turbine speed stably and subtly in response to small disturbances associated with the load and aggressively in response to large disturbances associated with the load, as well as smooth transitions between the responses. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/665800 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/12 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 9/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287847 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junhui Liu (Washington, District of Columbia); Ephraim Gutmark (Cincinnati, Ohio); Allan Aubert (Washington, District of Columbia) |
| ABSTRACT | Methods and apparatuses for reducing engine noise provided. In one embodiment, an apparatus is provided that includes a plurality of seals and flaps that are interconnected and circumferentially arranged. Also included are a plurality of micro-vortex generator pairs respectively disposed in a circumferential manner on an interior surface of the seals. Each micro-vortex generator pair includes a first and second micro-vortex generator. In another embodiment, a method of generating a plurality of vortices in a nozzle section of a jet engine is provided. A plurality of micro-vortex generator pairs are provided on a plurality of seal surfaces of the nozzle section, respectively. The micro-vortex generator pairs are constructed to generate two vortices adjacent to an interior surface of the nozzle section and extending in a direction towards a nozzle exit. The interaction between the nozzle flow and the micro-vortex generator pairs greatly modify the shock cell structure within the nozzle section and the turbulence structure in the jet plume. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/141586 |
| CURRENT CPC | Jet-propulsion Plants F02K 1/827 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/127 (20130101) F05D 2240/128 (20130101) F05D 2260/96 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288173 | Kisailus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Kisailus (Riverside, California); Wei Huang (Riverside, California) |
| ABSTRACT | Described herein are composite materials that can include a stiff phase and a compliant phase where the stiff phase forms an interpenetrating network within the compliant phase, the interpenetrating network can be described as bi-continuous phase, such as a gyroid phase. Also described are methods of making these materials. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 18/016435 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 71/02 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/0492 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288200 | EKHOLM |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Woods Hole Oceanographic Institution (Woods Hole, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander K. EKHOLM (Falmouth, Massachusetts) |
| ABSTRACT | A device and method of using same having an inertial measurement unit (IMU), a controller, an activator, and an absolute position sensor configured to measure fluid-body waves. The controller calculates its orientation in a relative frame using data obtained from the IMU and fixed-point arithmetic. The controller transforms the relative orientation information into absolute units using data obtained from the absolute sensor and fixed-point arithmetic, producing wave measurements. The controller may then select a subset of wave measurements for transmission via an optional communications mechanism to a remote user. |
| FILED | Saturday, March 11, 2023 |
| APPL NO | 18/120365 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/004 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288248 | Huang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuping Huang (Norwood, New Jersey); Yongmeng Sua (Fort Lee, New Jersey); Patrick Rehain (Allendale, New Jersey); Shenyu Zhu (Jersey City, New Jersey); Daniel Tafone (Port Murray, New Jersey); Jeevanandha Ramanathan (Jersey City, New Jersey) |
| ABSTRACT | Approaches, apparatuses and methods for single photon sensitive, non-interferometric photonics vibrometry applications based on quantum parametric mode sorting, optical gating and single photon counting are disclosed. In one embodiment, a controller module includes a photon detection unit, a pulse generator unit, a time synchronization unit, a data acquisition and processing unit and a central controller unit. In the second embodiment, a probe module with beam raster scanning ability includes an optical transceiver unit based on a bidirectional monostatic coaxial arrangement using off-the-shelf optical components and an optical beam steering device. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/899493 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/004 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0071 (20130101) H01S 3/1106 (20130101) H01S 3/094026 (20130101) H01S 3/094076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288412 | Kidwell |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Kidwell (Alexandria, Virginia) |
| ABSTRACT | The present invention provides for an analysis system and method that determines the presence of an analyte by generating electrical voltage and current. The intensity of the current is proportional to the amount of analyte present. |
| FILED | Wednesday, March 08, 2023 |
| APPL NO | 18/119276 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5438 (20130101) G01N 33/54388 (20210801) Original (OR) Class G01N 2033/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288549 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Nanyang Technological University (Singapore, Singapore) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Nanyang Technological University (Singapore, Singapore) |
| INVENTOR(S) | Ziqi Wang (Los Angeles, California); Mani Srivastava (Sherman Oaks, California); Akash Deep Singh (Los Angeles, California); Luis Garcia (Los Angeles, California); Zhe Chen (Singapore, Singapore); Jun Luo (Singapore, Singapore) |
| ABSTRACT | Systems and methods for simultaneously recovering and separate sounds from multiple sources using Impulse Radio Ultra-Wideband (IR-UWB) signals are described. In one embodiment, a device can be configured for generating an audio signal based on audio source ranging using ultrawideband signals. In an embodiment the device includes, a transmitter circuitry, a receiver circuitry, memory and a processor. The processor configured to generate a radio signal. The radio signal including an ultra-wideband Gaussian pulse modulated on a radio-frequency carrier. The processor further configured to transmit the radio signal using the transmitter circuitry, receive one or more backscattered signals at the receiver circuitry, demodulate the one or more backscattered signals to generate one or more baseband signals, and generate a set of data frames based on the one or more baseband signals. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 18/055772 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/414 (20130101) G01S 7/2813 (20130101) G01S 7/2923 (20130101) G01S 13/0209 (20130101) Original (OR) Class G01S 13/888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288637 | Hermans et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Artur Hermans (Boston, Massachusetts); Adrian Johannes Menssen (Cambridge, Massachusetts); Christopher Louis Panuski (Somerville, Massachusetts); Ian Robert Christen (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | An atom control architecture based on VIS-IR photonic integrated circuit (PIC) technology is characterized by (1) visible (VIS) and near-infrared (IR) wavelength operation, (2) channel counts extensible beyond 1000s of individually addressable atoms, (3) high intensity modulation extinction and (4) repeatability compatible with low gate errors, and (5) fast switching times. A 16-channel SiN-based APIC with (5.8±0.4) ns response times and <−30 dB extinction ratio at a wavelength of 780 nm. Based on a complementary metal-oxide-semiconductor (CMOS) fabrication process, this atom-control PIC (APIC) technology can be used for atomic, molecular, and optical physics and emerging applications, from quantum computers with cold atoms or ions to quantum networks with solid-state color centers. This APIC technology is especially suitable for scalable quantum information processing based on optically programmable atomic systems. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152638 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/124 (20130101) G02B 6/1225 (20130101) Original (OR) Class G02B 6/12002 (20130101) G02B 2006/12061 (20130101) G02B 2006/12142 (20130101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288716 | RUBIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Noah A. RUBIN (Cambridge, Massachusetts); Jan Philipp Balthasar MUELLER (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | An optical component comprises a metasurface comprising nanoscale elements. The metasurface is configured to receive incident light and to generate optical outputs. The geometries and/or orientations of the nanoscale elements provide a first optical output upon receiving a polarized incident light with a first polarization, and provide a second optical output upon receiving a polarized incident light with a second polarization that is different from the first polarization. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/120958 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/3083 (20130101) G02B 27/283 (20130101) G02B 27/286 (20130101) Original (OR) Class G02B 2207/101 (20130101) Holographic Processes or Apparatus G03H 1/0244 (20130101) G03H 2222/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288773 | Abdollahramezani et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sajjad Abdollahramezani (Atlanta, Georgia); Ali Adibi (Atlanta, Georgia); Omid Hemmatyar (Atlanta, Georgia); Hossein Taghinejad (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a reconfigurable hybrid metal-dielectric metasystem having a phase change material configured to reversibly transform between an amorphous state and a crystalline state upon a triggering event. The phase change material can be abutting a dielectric material on a first surface of the phase change material and a plasmonic material on an opposing second surface of the phase change material. An additional embodiment of the system includes when light travels through the system, the phase change material in the amorphous state can be configured to absorb a range of light, whereas the phase change material in the crystalline state can be configured to reflect the same range of light. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 18/005681 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/19 (20130101) Original (OR) Class G02F 2201/50 (20130101) G02F 2202/30 (20130101) G02F 2203/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288774 | Corato Zanarella et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mateus Corato Zanarella (New York, New York); Andres Gil Molina (New York, New York); Xingchen Ji (New York, New York); Min Chul Shin (New York, New York); Aseema Mohanty (New York, New York); Michal Lipson (New York, New York) |
| ABSTRACT | Methods, systems, and devices for light emission are disclosed. An example device may comprise an optical source configured to output light, a waveguide optically coupled to the optical source and configured to carry the light, and a feedback portion configured to reflect the light back to the optical source via the waveguide. The feedback portion may comprise a microresonator optically coupled to the waveguide. The device may comprise one or more tuning elements configured to tune one or more of the microresonator or the waveguide to cause constructive interference between the reflected light and light of the optical source, resulting in optical emission of both the reflected light and the light of the optical source from an end of the waveguide. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 18/052377 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/225 (20130101) Original (OR) Class G02F 2201/06 (20130101) G02F 2203/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230289557 | OLSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Edwin OLSON (Ann Arbor, Michigan); Dhanvin H. MEHTA (Ann Arbor, Michigan); Gonzalo FERRER (Ann Arbor, Michigan) |
| ABSTRACT | In Multi-Policy Decision-Making (MPDM), many computationally-expensive forward simulations are performed in order to predict the performance of a set of candidate policies. In risk-aware formulations of MPDM, only the worst outcomes affect the decision making process, and efficiently finding these influential outcomes becomes the core challenge. Recently, stochastic gradient optimization algorithms, using a heuristic function, were shown to be significantly superior to random sampling. In this disclosure, it was shown that accurate gradients can be computed—even through a complex forward simulation—using approaches similar to those in dep networks. The proposed approach finds influential outcomes more reliably, and is faster than earlier methods, allowing one to evaluate more policies while simultaneously eliminating the need to design an easily-differentiable heuristic function. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/196897 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) Original (OR) Class G06N 3/008 (20130101) G06N 3/084 (20130101) G06N 7/01 (20230101) Pictorial Communication, e.g Television H04N 1/00002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230289920 | Bruder et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerd Bruder (Orlando, Florida); Gregory Welch (Orlando, Florida); Kangsoo Kim (Orlando, Florida); Zubin Choudhary (Orlando, Florida) |
| ABSTRACT | One or more cameras capture objects at a higher resolution than the human eye can perceive. Objects are segmented from the background of the image and scaled to human perceptible size. The scaled-up objects are superimposed over the unscaled background. This is presented to a user via a display whereby the process selectively amplifies the size of the objects’ spatially registered retinal projection while maintaining a natural (unmodified) view in the remainder of the visual field. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/853072 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) Original (OR) Class G06T 7/73 (20170101) G06T 7/194 (20170101) G06T 19/006 (20130101) Image or Video Recognition or Understanding G06V 10/764 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290493 | Redwood et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Owen Redwood (Omaha, Nebraska); Jeff Dunn (Omaha, Nebraska); Riley Hester (Omaha, Nebraska); Ian Trent (Omaha, Nebraska); Eric Wright (Omaha, Nebraska); Brad Miller (Omaha, Nebraska); Orly Tauil (Omaha, Nebraska) |
| ABSTRACT | Methods and systems for medical device diagnostics and reporting. One system including an electronic processor configured to receive a new medical device dataset associated with a medical device. The electronic processor is also configured to determine an operation classification of the medical device using a model utilizing training information. The training information includes a plurality of archived medical device datasets and an associated operation classification for each of the plurality of archived medical device datasets. The electronic processor is also configured determine an operation status of the medical device based on the operation classification. The electronic processor is also configured to generate and provide a notification based on at least the operation status of the medical device. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 18/007217 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/40 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230291167 | Carey et al. |
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| FUNDED BY |
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| APPLICANT(S) | Phase Sensitive Innovations, Inc. (Newark, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victoria Carey (Newark, Delaware); Charles Harrity (Newark, Delaware); Eliezer Shahid (Newark, Delaware); Matthew Konkol (Newark, Delaware); Christopher Schuetz (Avondale, Pennsylvania); Peng Yao (Newark, Delaware); Dennis Prather (Newark, Delaware) |
| ABSTRACT | An RF pulse generator may comprise a pair of phase-locked lasers that output optical tones offset in frequency by a set amount. The resulting optical signal is periodically transmitted and blocked by an optical switch to generate a pulsed optical signal. A photodiode is irradiated with the pulsed optical signal to generate a corresponding pulsed RF signal having a frequency corresponding to the frequency difference of the optical tones generated by the phase-locked lasers. An antenna may be connected to and driven by the photodiode to electromagnetically transmit the pulsed RF signal. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/120985 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0085 (20130101) H01S 3/1112 (20130101) Original (OR) Class H01S 3/06754 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230291419 | Yoder |
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| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore James Yoder (White Plains, New York) |
| ABSTRACT | Techniques regarding quantum error correction are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a maximum-likelihood decoder component that executes a maximum-likelihood decoding algorithm to determine an error correction based on a decoding hypergraph that characterizes error-sensitive events associated with a quantum error-correcting code executed on a quantum circuit. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/654545 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 13/01 (20130101) H03M 13/09 (20130101) H03M 13/1125 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230291467 | GE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Howard H. GE (Hacienda Heights, California); Erin Y. HONG (Lawndale, California); Richard Y. CHIANG (Torrance, California); Devon FEASTER (Torrance, California); Tuong-Vi Thi TRAN (Garden Grove, California); Michael ANDONIAN (Los Angeles, California) |
| ABSTRACT | Embodiments of the present invention include a two-stage blending filter that blends the measurements from two angular sensors to form a single superior high bandwidth measurement for improved disturbance rejection in a satellite systems for increased accuracy in satellite pointing, orientation, and attitude control. Embodiments of the present invention can include a satellite system including a first sensor including or defining a first measurement bandwidth; a first filter connected to the first sensor; a second sensor including or defining a second measurement bandwidth; a second filter connected to the second sensor; and a third filter connected to the first filter and the second filter. The third filter blend the first signal and the second signal into a third signal; and transmit the third signal to a flight controller configured to adjust an orientation of the satellite, a satellite subsystem, or both, relative to a target in response to the third signal. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691696 |
| CURRENT CPC | Transmission H04B 1/1018 (20130101) H04B 7/18539 (20130101) Original (OR) Class H04B 7/18591 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230291541 | Gupta et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saransh Gupta (La Jolla, California); Tajana Simunic Rosing (San Diego, California) |
| ABSTRACT | A method of operating on encrypted data can be performed by receiving ciphertexts at a server that is configured to operate on the ciphertexts generated using a 3rd generation RGSW based fully homomorphic encryption system, operating on the ciphertexts received at the server in response to requested operations to generate respective input ciphertexts including ciphertext polynomials and ciphertext integers that are representative of the input ciphertexts, and processing the input ciphertexts in a server processing-in-memory device, that is operatively coupled to the server, to perform operations on the input ciphertext using the server processing-in-memory device, in-situ. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152313 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/008 (20130101) Original (OR) Class H04L 9/0825 (20130101) H04L 9/3026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230285543 | BOGDAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Paul BOGDAN (Los Angeles, California); Shahin NAZARIAN (Los Angeles, California); Zikun YANG (Los Angeles, California) |
| ABSTRACT | Computer systems and computer implemented methods are presented for designing and making vaccines to pathogens, particular viral pathogens. Vaccine compositions for COVID-19 are also disclosed, as well as method of using the same. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 18/016230 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285636 | Alsberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); WORCESTER POLYTECHNIC INSTITUTE (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eben Alsberg (Cleveland, Ohio); Anna D. Dikina (Cleveland, Ohio); Marsha W. Rolle (Worcester, Massachusetts) |
| ABSTRACT | A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968476 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 27/3804 (20130101) A61L 27/3882 (20130101) Original (OR) Class A61L 2300/62 (20130101) A61L 2300/414 (20130101) A61L 2300/602 (20130101) A61L 2400/12 (20130101) A61L 2430/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0075 (20130101) C12N 2513/00 (20130101) C12N 2531/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285910 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mengying Yang (Port Washington, New York); Benjamin S. Hsiao (Setauket, New York) |
| ABSTRACT | The present disclosure provides a nanostructured cellulose membrane system with high porosity, and methods for making same. The cellulose membrane system includes carboxylate-functionalized cellulose nanofibers combined with a cellulose microfiber scaffold, which are attached by a crosslinking reaction between the nanofibers and/or between the nanofibers and the microfiber scaffold. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/120470 |
| CURRENT CPC | Separation B01D 67/0002 (20130101) B01D 67/00933 (20220801) B01D 69/02 (20130101) B01D 69/1214 (20220801) B01D 71/10 (20130101) Original (OR) Class B01D 2323/30 (20130101) B01D 2323/081 (20220801) B01D 2325/04 (20130101) B01D 2325/20 (20130101) B01D 2325/40 (20130101) B01D 2325/0281 (20220801) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/24 (20130101) B01J 20/3007 (20130101) B01J 20/3085 (20130101) B01J 20/28004 (20130101) B01J 20/28035 (20130101) B01J 20/28038 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285938 | OLSEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Diatomix Inc. (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua OLSEN (Portland, Oregon); Nicholas DAY (Portland, Oregon); Abigail PYEATT (Portland, Oregon) |
| ABSTRACT | A composition comprising catalytic materials mixed with diatomaceous earth is provided, wherein, when the composition is exposed to irradiance, heat or other necessary activation environmental factors, the composition actively removes and degrades volatile organic compounds and/or metal ions from air or water streams. The composition can contain binding agents, rheology modifiers, and is shaped via compression or molding to be easily handled. Additionally, the composition can be used in forced-air or water streams to actively remove and degraded volatile organic compounds and/or metal ions from air or water streams. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 18/006023 |
| CURRENT CPC | Separation B01D 53/8687 (20130101) B01D 2255/802 (20130101) B01D 2255/20707 (20130101) B01D 2257/93 (20130101) B01D 2257/708 (20130101) B01D 2258/06 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/08 (20130101) Original (OR) Class B01J 21/063 (20130101) B01J 35/004 (20130101) B01J 35/023 (20130101) B01J 35/026 (20130101) B01J 37/04 (20130101) B01J 37/08 (20130101) B01J 37/0018 (20130101) Reclamation of Contaminated Soil B09C 1/08 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/30 (20130101) C02F 1/725 (20130101) C02F 2101/30 (20130101) C02F 2305/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286015 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | Villanova University (Villanova, Pennsylvania) |
| ASSIGNEE(S) | Villanova University (Villanova, Pennsylvania) |
| INVENTOR(S) | Bo Li (Malvern, Pennsylvania); Liang Zhao (Bryn Mawr, Pennsylvania) |
| ABSTRACT | A method for forming a nanomaterial coating through solute-assisted assembly is provided. The method includes steps of: providing a mixture comprising a solvent, a solute, and a nanomaterial or particle; applying sonication to the mixture; and contacting a substrate with the mixture so as to form a coating of the nanomaterial or the particle onto the substrate. The solute is selected from a salt, a sugar, an acid, a base, or a combination thereof. The present disclosure also provides the resulting products comprising the nanomaterial coating for flexible electronics and functional textiles. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 17/989823 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 23/405 (20220101) B01F 31/80 (20220101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/18 (20130101) Original (OR) Class B05D 7/24 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286047 | Mirkin et al. |
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| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Vinayak P. Dravid (Evanston, Illinois); Liban Jibril (Evanston, Illinois) |
| ABSTRACT | A method of forming a nanoparticle can include admixing an aqueous solution into an oil-phase to thereby form an emulsion of droplets of the aqueous solution in the oil phase, the aqueous solution comprising a nanostructure precursor and a polymer, adding a silane precursor and catalyst to form a silica shell around each of the droplets to nanoreactors; annealing at a first temperature below the decomposition temperature of the polymer to aggregate the nanostructure precursor within the nanoreactor; and annealing at a second temperature above the decomposition temperature of the polymer to convert the aggregated nanostructure precursor to the nanostructure and decompose the polymer. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/118031 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/16 (20220101) B22F 1/054 (20220101) B22F 9/26 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286177 | Su et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Colmbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haijun Su (Columbus, Ohio); George Crowley (Columbus, Ohio); Xianpai Zeng (Columbus, Ohio) |
| ABSTRACT | A finger for a robotic gripper may include a flexible actuator, a flexible backbone, a rigid constraint frame, a plurality of jamming layers, and a jamming bag. The flexible actuator may have a proximal end, a distal end disposed opposite the proximal end, a first side, and a second side disposed opposite the first side. The flexible backbone may be coupled to the flexible actuator and disposed along the first side of the flexible actuator. The rigid constraint frame may be coupled to the flexible actuator and disposed along the second side of the flexible actuator. The jamming layers may be coupled to the flexible actuator and disposed at least partially within the rigid constraint frame. The jamming bag disposed at least partially within the rigid constraint frame and configured to apply a compressive force to the jamming layers when a positive pressure is generated within the jamming bag. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/114781 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 15/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286873 | Cui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NUtech Ventures, Inc. (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bai Cui (Lincoln, Nebraska); Fei Wang (Lincoln, Nebraska); Yongfeng Lu (Lincoln, Nebraska); Michael Nastasi (Lincoln, Nebraska) |
| ABSTRACT | Systems for and methods for improving mechanical properties of ceramic material are provided. The system comprises a heat source for heating the ceramic material to a temperature greater than a brittle-to-ductile transition temperature of the ceramic material; a probe for mounting the ceramic material and configured to extend the ceramic material into the heat source; a plasma-confining medium and a sacrificial layer disposed between the ceramic material and the plasma-confining medium; and an energy pulse generator such as a laser pulse generator. The sacrificial layer is utilized to form plasma between the ceramic material and the plasma-confining medium. The method comprises heating ceramic material to a temperature greater than a brittle-to-ductile transition temperature of the ceramic material and subjecting the ceramic material to energy pulses via a sacrificial layer and a plasma-confining medium whereby a plasma of the sacrificial coating forms between the ceramic material and a plasma-confining medium. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/310395 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/53 (20151001) B23K 26/083 (20130101) B23K 26/356 (20151001) B23K 26/0622 (20151001) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 11/005 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/10 (20130101) C04B 41/0036 (20130101) C04B 41/0072 (20130101) Original (OR) Class C04B 41/4527 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287503 | QUAKE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Stephen QUAKE (Stanford, California); Hei-Mun Christina FAN (Fremont, California) |
| ABSTRACT | The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital analysis is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents. |
| FILED | Wednesday, April 26, 2023 |
| APPL NO | 18/307093 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6851 (20130101) C12Q 1/6858 (20130101) C12Q 1/6881 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/143333 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287585 | Ozkan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Umit Ozkan (Columbus, Ohio); Seval Gunduz (Columbus, Ohio); Dhruba Jyoti Deka (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are doped perovskite oxides. The doped perovskite oxides may be used as a cathode material in an electrochemical cell to electrochemically generate ammonia from N2. The doped perovskite oxides may be combined with nitride compounds, for instance iron nitride, to further increase the efficiency of the ammonia production. |
| FILED | Wednesday, April 26, 2023 |
| APPL NO | 18/307289 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 49/009 (20130101) C01G 51/70 (20130101) C01G 53/70 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/34 (20130101) C01P 2002/50 (20130101) C01P 2006/40 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/2633 (20130101) C04B 35/2641 (20130101) C04B 35/58042 (20130101) C04B 2235/3274 (20130101) C04B 2235/3852 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/00 (20130101) C25B 1/27 (20210101) C25B 9/19 (20210101) C25B 9/23 (20210101) C25B 11/047 (20210101) C25B 11/051 (20210101) C25B 11/069 (20210101) Original (OR) Class C25B 11/0773 (20210101) C25B 13/04 (20130101) C25B 13/07 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287682 | Blundo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyler Blundo (Ringwood, New Jersey); Christiana Honsberg (Tempe, Arizona); Stephen Goodnick (Fort McDowell, Arizona); Richard King (Tempe, Arizona); Nicholas Irvin (Phoenix, Arizona) |
| ABSTRACT | A skylight for a building includes a solar panel arranged within the skylight, the solar panel comprising one or more photovoltaic cells to collect direct radiation from rays of sunlight for conversion to electrical power, and an optical element to receive the direct radiation and refract it to the solar panel, and to receive the direct radiation and diffuse radiation scattered from the rays of sunlight and refract the direct radiation and the diffuse radiation through the skylight, bypassing the solar panel, to provide daylighting in the building. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/316943 |
| CURRENT CPC | Roof Coverings; Sky-lights; Gutters; Roof-working Tools E04D 13/033 (20130101) Original (OR) Class Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 9/24 (20130101) E06B 2009/2417 (20130101) E06B 2009/2494 (20130101) Non-portable Lighting Devices; Systems Thereof; Vehicle Lighting Devices Specially Adapted for Vehicle Exteriors F21S 11/002 (20130101) Optical Elements, Systems, or Apparatus G02B 5/32 (20130101) G02B 5/208 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/26 (20141201) H02S 40/22 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288239 | Wang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Guiren Wang (Irmo, South Carolina) |
| ABSTRACT | The present disclosure provides methods and systems for flight velocimetry employing at least one bleaching laser, at least one detection laser, at least one dichroic mirror, an objective, a detection system, and a nano stage to bleach a dye to form a bleached blot in a flow pathway. |
| FILED | Thursday, May 18, 2023 |
| APPL NO | 18/319611 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0261 (20130101) A61B 5/0285 (20130101) Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/206 (20130101) G01F 1/661 (20130101) G01F 1/7086 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/02 (20130101) H01S 3/005 (20130101) H01S 3/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288354 | Cianfrocco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Cianfrocco (Ann Arbor, Michigan); Quanfu Fan (Lexington, Massachusetts); Yilai Li (Ann Arbor, Michigan); Seychelle Vos (Cambridge, Massachusetts) |
| ABSTRACT | Methods and systems for performing electron microscopy are provided. Microscopy images candidate sub-regions at different magnification levels are captured and provided to a trained sub-region quality assessment application trained to output a quality score for each candidate sub-region. From the quality scores, group-level features for the larger magnification images are determined using a group-level feature extraction application. The quality scores for the candidate sub-regions and the group-level extraction features are provided to a trained Q-learning network that identifies a next sub-region amongst the candidate sub-regions for capturing a micrograph image, where reinforcement learning may be used with the Q-learning network for such identification, for example using a decisional cost. |
| FILED | Wednesday, March 08, 2023 |
| APPL NO | 18/119117 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/2251 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/97 (20170101) G06T 2207/10061 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288477 | Chakrabarty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krishnendu Chakrabarty (Durham, North Carolina); Jonti Talukdar (Durham, North Carolina); Arjun Chaudhuri (Durham, North Carolina) |
| ABSTRACT | An integrated circuit (IC) protection circuit can include a reconfigurable block that receives a seed value from a tamper-proof memory and generates a dynamic key; an authentication block that receives the dynamic key from the reconfigurable block and taint bits from a scan chain to generate an authentication signature; and an encryptor that encrypts a test pattern response on the scan chain if a mismatch is found between the authentication signature and a test pattern embedded signature. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/693942 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/3177 (20130101) Original (OR) Class G01R 31/31703 (20130101) Electric Digital Data Processing G06F 11/263 (20130101) G06F 2201/83 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288549 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Nanyang Technological University (Singapore, Singapore) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Nanyang Technological University (Singapore, Singapore) |
| INVENTOR(S) | Ziqi Wang (Los Angeles, California); Mani Srivastava (Sherman Oaks, California); Akash Deep Singh (Los Angeles, California); Luis Garcia (Los Angeles, California); Zhe Chen (Singapore, Singapore); Jun Luo (Singapore, Singapore) |
| ABSTRACT | Systems and methods for simultaneously recovering and separate sounds from multiple sources using Impulse Radio Ultra-Wideband (IR-UWB) signals are described. In one embodiment, a device can be configured for generating an audio signal based on audio source ranging using ultrawideband signals. In an embodiment the device includes, a transmitter circuitry, a receiver circuitry, memory and a processor. The processor configured to generate a radio signal. The radio signal including an ultra-wideband Gaussian pulse modulated on a radio-frequency carrier. The processor further configured to transmit the radio signal using the transmitter circuitry, receive one or more backscattered signals at the receiver circuitry, demodulate the one or more backscattered signals to generate one or more baseband signals, and generate a set of data frames based on the one or more baseband signals. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 18/055772 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/414 (20130101) G01S 7/2813 (20130101) G01S 7/2923 (20130101) G01S 13/0209 (20130101) Original (OR) Class G01S 13/888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230289473 | ARORA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Sanjeev ARORA (Princeton, New Jersey); Kai LI (Princeton, New Jersey); Yangsibo HUANG (Princeton, New Jersey); Zhao SONG (Princeton, New Jersey); Danqi CHEN (Princeton, New Jersey) |
| ABSTRACT | According to various embodiments, a method for encrypting image data for a neural network are disclosed. The method includes mixing the image data with other datapoints to form mixed data; and applying a pixel-wise random mask to the mixed data to form encrypted data. According to various embodiments, a method for encrypting text data for a neural network for natural language processing is disclosed. The method includes encoding each text datapoint via a pretrained text encoder to form encoded datapoints; mixing the encoded datapoints with other encoded datapoints to form mixed data; applying a random mask to the mixed data to form encrypted data; and incorporating the encrypted data into training a classifier of the neural network and fine-tuning the text encoder. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 18/009765 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/602 (20130101) G06F 21/6254 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/098 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230289599 | Sidhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tesla, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harsimran Singh Sidhu (Fremont, California); Paras Jagdish Jain (Cupertino, California); Daniel Paden Tomasello (Los Altos Hills, California); Forrest Nelson Iandola (San Jose, California) |
| ABSTRACT | A model training and implementation pipeline trains models for individual embedded systems. The pipeline iterates through multiple models and estimates the performance of the models. During a model generation stage, the pipeline translates the description of the model together with the model parameters into an intermediate representation in a language that is compatible with a virtual machine. The intermediate representation is agnostic or independent to the configuration of the target platform. During a model performance estimation stage, the pipeline evaluates the performance of the models without training the models. Based on the analysis of the performance of the untrained models, a subset of models is selected. The selected models are then trained and the performance of the trained models are analyzed. Based on the analysis of the performance of the trained models, a single model is selected for deployment to the target platform. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/183515 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) G05D 1/0214 (20130101) G05D 1/0221 (20130101) G05D 2201/0213 (20130101) Electric Digital Data Processing G06F 9/45533 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290145 | Chaterji et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Somali Chaterji (West Lafayette, Indiana); Saurabh Bagchi (est Lafayette, Indiana); Ran Xu (West Lafayette, Indiana) |
| ABSTRACT | A system may receive video information. The system may select a combination of light-weight features and heavy weight features. The light-weight features may be extracted from the video information and the heavy weight features not extracted. The system may forecast, based on the light-weight features and the heavy weight features, accuracy, and latency metrics for performing the object detection and tracking using a plurality of candidate branch configurations, respectively. The system may select a branch configuration from the plurality of candidate branch configurations in response to satisfaction of an optimization criterion. The system may perform object detection and tracking based on the selected branch configuration. |
| FILED | Friday, March 10, 2023 |
| APPL NO | 18/120285 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/20 (20130101) Image or Video Recognition or Understanding G06V 20/46 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290707 | Avval et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Fayetteville, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Fayetteville, Arkansas) |
| INVENTOR(S) | Amirreza Ghadimi Avval (Fayetteville, Arkansas); Samir El-Ghazaly (Fayetteville, Arkansas); Gregory J. Salamo (Fayetteville, Arkansas); Shui-Qing Yu (Fayetteville, Arkansas) |
| ABSTRACT | A semiconductor heat sink made of a first material including a plurality of spaced-apart depressions and an area surrounding the depressions filled with one or more materials having a heat conductivity greater than the first material. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155612 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/433 (20130101) Original (OR) Class H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290954 | Baumann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland); Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Avery E. Baumann (Baltimore, Maryland); Van Sara Thoi (Baltimore, Maryland); Julia R. Downing (Evanston, Illinois); Mark C. Hersam (Evanston, Illinois) |
| ABSTRACT | A composition for producing electrodes for lithium-sulfur batteries includes particles having a metal-organic framework structure and composition that define voids within the metal-organic framework structure; sulfur loaded into at least some of the voids defined by the metal-organic framework structure of the particles; graphene flakes obtained by polymer enhanced solvent exfoliation; and polymer residue from the polymer enhanced solvent exfoliation. A method of producing a composite electrode for a lithium-sulfur battery according to an embodiment of the current invention includes obtaining a composition according to an embodiment of the current invention and applying the composition to a substrate. An electrode for a lithium-sulfur battery includes a layer having the composition. A lithium-sulfur battery according to an embodiment of the current invention includes the electrode. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 18/017372 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/19 (20170801) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/60 (20130101) H01M 4/625 (20130101) Original (OR) Class H01M 10/052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230291203 | Narayanaswamy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vivek Sivaraman Narayanaswamy (Tempe, Arizona); Rajapandian Ayyanar (Chandler, Arizona); Cihan Tepedelenlioglu (Chandler, Arizona); Andreas Spanias (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Vivek Sivaraman Narayanaswamy (Tempe, Arizona); Rajapandian Ayyanar (Chandler, Arizona); Cihan Tepedelenlioglu (Chandler, Arizona); Andreas Spanias (Tempe, Arizona) |
| ABSTRACT | A system reconfigures a photovoltaic array used in solar energy based on observed shading conditions to determine an optimal topology of the photovoltaic array to maximize power output. Specifically, the system is designed to reconfigure a photovoltaic array when the photovoltaic array is partially shaded. The system uses a neural network model to determine a topology that maximizes power output of the photovoltaic array based on irradiance data obtained from the photovoltaic array. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/121388 |
| CURRENT CPC | Systems for Regulating Electric or Magnetic Variables G05F 1/67 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/004 (20200101) Original (OR) Class H02J 2300/26 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230291541 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saransh Gupta (La Jolla, California); Tajana Simunic Rosing (San Diego, California) |
| ABSTRACT | A method of operating on encrypted data can be performed by receiving ciphertexts at a server that is configured to operate on the ciphertexts generated using a 3rd generation RGSW based fully homomorphic encryption system, operating on the ciphertexts received at the server in response to requested operations to generate respective input ciphertexts including ciphertext polynomials and ciphertext integers that are representative of the input ciphertexts, and processing the input ciphertexts in a server processing-in-memory device, that is operatively coupled to the server, to perform operations on the input ciphertext using the server processing-in-memory device, in-situ. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152313 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/008 (20130101) Original (OR) Class H04L 9/0825 (20130101) H04L 9/3026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230285446 | Alverdy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois); UChicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | John C. Alverdy (Glenview, Illinois); Matthew Tirrell (Chicago, Illinois); Olga Y. Zaborina (Brookfield, Illinois); Jun Mao (Chicago, Illinois); Wei Chen (Chicago, Illinois) |
| ABSTRACT | The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage. |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/156058 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0095 (20130101) A61K 31/77 (20130101) Original (OR) Class A61K 31/80 (20130101) A61K 31/765 (20130101) A61K 47/10 (20130101) A61K 47/34 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 31/04 (20180101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/3353 (20130101) C08G 81/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286045 | Bass et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryann E. Bass (Ammon, Idaho); Jorgen Rufner (Idaho Falls, Idaho); Michael D. McMurtrey (Idaho Falls, Idaho); Xinchang Zhang (Idaho Falls, Idaho); Troy B. Holland (New Albany, Indiana) |
| ABSTRACT | A method of forming an article comprises placing a first material and a second material in a die of a direct current sintering apparatus. The second material directly contacts the first material. An electric current and pressure are applied to the first material and the second material to form an article. An additional method comprises placing a nickel-based material in direct contact with one or more other nickel-based materials to form a stack of nickel-based materials. An electric current and pressure are applied to the stack of nickel-based materials to join the nickel-based material and the one or more other nickel-based materials. Related articles are also disclosed. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/183513 |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 53/04 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 7/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286158 | Beer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | N. Reginald Beer (Pleasanton, California); David H. Chambers (Livermore, California); Jeffrey Edward Mast (Loveland, Colorado) |
| ABSTRACT | A system for generating a machine learning system to generate guidance information based on locations of objects is provided. The system accesses training data that includes training time-of-arrival (“TOA”) information of looks and guidance information for each look. The guidance information is based on a training collection of object locations. The TOA of a look represents, for each object location of a training collection of object locations, times between signals transmitted by transmitters and return signals received by receivers. The return signals represent signals reflected from an object at the object location. The system trains a machine learning system using the training data wherein the machine learning system inputs TOA information and outputs guidance information. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/316518 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1676 (20130101) Original (OR) Class Aeroplanes; Helicopters B64C 39/024 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 10/13 (20230101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) G05D 1/101 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 2207/30252 (20130101) Image or Video Recognition or Understanding G06V 20/10 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230286489 | Shakya et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bijesh M. Shakya (Columbus, Indiana); Kesavan Ramakrishnan (Columbus, Indiana) |
| ABSTRACT | Emissions management systems for engines in hybrid systems include a sensor assembly and a controller. Sensor assembly is configured to provide an activation signal in response to an engine start event and to detect emissions information, including information indicative of an engine power, a driver demanded power, a catalyst temperature, a battery state of charge, and a battery temperature. Controller communicates with sensor assembly and is configured to: receive activation signal and, in response, emissions information from sensor assembly; determine an emissions reduction mode having a threshold value for catalyst temperature and having an engine power corresponding thereto; monitor emissions information; compare catalyst temperature to threshold value; cause the engine to operate in emissions reduction mode while catalyst temperature is less than threshold value; and allow the engine to operate in a normal operation mode while catalyst temperature is greater than or equal to the threshold value. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 18/014403 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 10/06 (20130101) Original (OR) Class B60W 10/26 (20130101) B60W 2510/244 (20130101) B60W 2510/246 (20130101) B60W 2710/0677 (20130101) Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines F01N 11/002 (20130101) F01N 2590/11 (20130101) F01N 2900/08 (20130101) F01N 2900/104 (20130101) F01N 2900/1602 (20130101) F01N 2900/1626 (20130101) Controlling Combustion Engines F02D 29/02 (20130101) F02D 41/062 (20130101) F02D 41/0255 (20130101) F02D 2200/0802 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287153 | SCHMIDT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Robert D. SCHMIDT (Howell, Michigan); Shuru CHEN (Troy, Michigan); Fang DAI (Troy, Michigan); Mei CAI (Bloomfield Hills, Michigan) |
| ABSTRACT | Methods for forming sulfur polyacrylonitrile are provide. In certain variations, the method includes contacting sulfur and polyacrylonitrile to form an admixture, sealing a container holding the admixture, heating the admixture to a first temperature venting the container holding the admixture to release gases generated during the heating of the admixture to the first temperature, re-sealing the container holding the admixture, and heating the admixture to a second temperature. In other variations, the method includes contacting sulfur and polyacrylonitrile to form an admixture, heating the admixture to a first temperature, sealing a container holding the admixture, and heating the admixture to a second temperature. The second temperature is greater than the first temperature. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690831 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/36 (20130101) Original (OR) Class C08F 120/44 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287439 | YOSHIKUNI et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yasuo YOSHIKUNI (Orinda, California); Gaoyan WANG (Pleasanton, California); Zhiying ZHAO (Danville, California); Robert Cameron COATES (Lafayette, California); Jan-Fang CHENG (Orinda, California); David ROBINSON (Martinez, California) |
| ABSTRACT | Provided herein are methods for integrating a gene of interest into a chromosome of a host cell. In some embodiments, the methods include introducing into a host cell a first plasmid comprising a transposase coding sequence and a donor sequence, which includes a selectable marker coding sequence flanked by a first and a second lox site and is itself flanked by inverted repeats recognized by the transposase. Following transposase-mediated chromosomal integration of the donor sequence into the host cell, a second plasmid is introduced, which comprises the gene of interest and a second selectable marker coding sequence, both flanked by a first and a second lox site. The gene of interest is chromosomally integrated into the host cell by recombinase-mediated cassette exchange (RMCE) between the donor sequence and the second plasmid via Cre-lox recombination. Further provided herein are host cells, vectors, and methods of producing a product related thereto. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311796 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 15/74 (20130101) C12N 15/78 (20130101) Original (OR) Class C12N 15/902 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287443 | OIKAWA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AFINGEN, INC. (Emeryville, California) |
| ASSIGNEE(S) | AFINGEN, INC. (Emeryville, California) |
| INVENTOR(S) | Ai OIKAWA (Emeryville, California) |
| ABSTRACT | The present invention provides compositions and methods for generating transgenic plants with increased plant growth and improved multiple yield-related traits, which comprise vascular xylem tissue-targeting overexpression of transcription factors (TFs) involved in vascular xylem cell development. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172699 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8223 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288342 | LARSEN, III et al. |
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| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina); UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (ATHENS, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | GEORGE K. LARSEN, III (AIKEN, South Carolina); THO D. NGUYEN (DACULA, Georgia); MINH THIEN PHAM (FALLS CHURCH, Virginia); HOANG M. LUONG (ATHENS, Georgia) |
| ABSTRACT | Hydrogen gas sensors with low cost, fast response time, large detection range, high sensitivity, and excellent limit of detection are described. The devices include a composite formed on a nano-scale that both absorbs hydrogen and exhibits magneto-optical effects. Sensor readout is based on magneto-optical effects, which also may be enhanced through plasmonic coupling. The hydrogen sensors are fast and sensitive, as well as resistant to surface poisoning from common contaminants, such as carbon monoxide. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/105071 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/77 (20130101) Original (OR) Class G01N 21/554 (20130101) G01N 33/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288352 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chengjun Sun (Naperville, Illinois); Mikhail A. Solovyev (Western Springs, Illinois); Steve Heald (Downers Grove, Illinois); Xiaoyi Zhang (Naperville, Illinois); Maria Chan (Chicago, Illinois); Shelly D. Kelly (Bolingbrook, Illinois) |
| ABSTRACT | Spectroscopy systems require a crystal having specific properties for analyzing a spectrum of a sample, which is typically performed for measuring the presence of one element at a time. A two-dimensional (2D) crystal mount for performing simultaneous spectroscopy measurements includes a crystal holder having multiple rows of crystal mounts. Each crystal mount is positioned and orientated to physically support a crystal at a fixed position and fixed orientation relative to an optical axis. A sample provides radiation to analyzer crystals disposed in the crystal mounts, and a detector may detect radiation reflected from the analyzer crystals, for performing multiple simultaneous spectroscopy measurements. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692994 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/2076 (20130101) Original (OR) Class G01N 23/20008 (20130101) G01N 2223/308 (20130101) G01N 2223/0568 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288362 | Aytug et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tolga Aytug (Oak Ridge, Tennessee); Christine Fisher (Oak Ridge, Tennessee); Pooran C. Joshi (Oak Ridge, Tennessee); Robert J. Warmack (Oak Ridge, Tennessee) |
| ABSTRACT | A low-cost and low-power polyaniline-based (PANI) gas sensor is provided. The PANI-based gas sensor is formed on a flexible polyimide (PI) substrate using additive manufacturing techniques. The gas sensor can include silver interdigitated electrode (IDE) arrays and conducting polymeric sensing films (i.e., PANI) that are printed onto the PI substrate using a direct-write technology of aerosol-jet printing. Aerosol-jet printing enables high-resolution, non-contact deposition of both the electrode and chemically sensitive materials. The gas sensor is optionally capable of 5 ppm sensitivity and a sub-ppm detection limit. |
| FILED | Wednesday, March 08, 2023 |
| APPL NO | 18/118920 |
| CURRENT CPC | Printing, Duplicating, Marking, or Copying Processes; Colour Printing, B41M 3/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/127 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288375 | Jacobson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Chevron U.S.A. Inc. (San Ramon, California); Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erica Marie Jacobson (Los Alamos, New Mexico); Ian Thomas Cummings (Los Alamos, New Mexico); Eric Brian Flynn (Santa Fe, New Mexico); Adam Joseph Wachtor (Los Alamos, New Mexico); Benjamin M. Chaloner-Gill (Alameda, California); Brock Genter (San Ramon, California); Martin Quintero (Houston, Texas); Ryan S. Sanders (Helena, Montana) |
| ABSTRACT | A structure including a substrate and a coating over the substrate is acoustically excited to measure acoustic response in the structure. The measured acoustic response in the structure is filtered to remove acoustic response of the substrate and determine acoustic response of the coating. The acoustic response of the coating is used to inspect the coating for failure. |
| FILED | Sunday, March 13, 2022 |
| APPL NO | 17/693369 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/07 (20130101) Original (OR) Class G01N 29/4427 (20130101) G01N 29/4463 (20130101) G01N 2291/011 (20130101) G01N 2291/0237 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230288692 | Ravizza |
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| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank Ravizza (Livermore, California) |
| ABSTRACT | In one aspect, an apparatus includes a first aspheric refractive surface defined by a first polynomial and positioned to receive input light, and a first aspheric mirror surface comprising a first reflective coating, the first mirror surface defined by a second polynomial and positioned to receive light from the first aspheric refractive surface. The apparatus includes a second aspheric mirror surface comprising a second reflective coating, the second aspheric mirror surface defined by a third polynomial and positioned to receive light from the first aspheric mirror surface, and a second aspheric refractive surface defined by a fourth polynomial and positioned to receive light from the second aspheric mirror surface, wherein the first aspheric refractive surface, the first aspheric mirror surface, the second aspheric mirror surface, and the second aspheric refractive surface are arranged to have a fixed alignment with respect to each other as part of a monolithic structure. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/654775 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 17/0808 (20130101) G02B 23/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230289644 | Rosenthal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric I. Rosenthal (San Mateo, California); Christopher P. Anderson (Menlo Park, California); Jelena Vuckovic (Palo Alto, California) |
| ABSTRACT | Improved spin-microwave coupling is provided using a microwave cavity having a galvanic element connecting two points on its walls. This configuration can provide an unusual cavity mode having a highly concentrated magnetic field (to provide good coupling to a spin system) and a spread-out electric field (to reduce loss, since the electric field is almost entirely in vacuum). The galvanic element preferably includes a nano-scale current concentration feature (i.e., sub 100 nm lateral dimensions) to concentrate the magnetic field. The spin system of interest is preferably disposed in proximity to this current concentration feature. Applications include coherent quantum optical-microwave transduction and quantum memories. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/121412 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290525 | GATES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DAVID GATES (PRINCETON, New Jersey); CAOXIANG ZHU (Hefei, China PRC); KENNETH HAMMOND (Plainsboro, New Jersey) |
| ABSTRACT | Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution. |
| FILED | Friday, March 10, 2023 |
| APPL NO | 18/119981 |
| CURRENT CPC | Fusion Reactors G21B 1/055 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290925 | Deng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zenlabs Energy, Inc. (Fremont, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haixia Deng (Fremont, California); Yongbong Han (San Francisco, California); Charan Masarapu (Fremont, California); Yogesh Kumar Agunchamy (Newark, California); Herman A. Lopez (Sunnyvale, California); Sujeet Kumar (Newark, California) |
| ABSTRACT | Silicon oxide based materials, including composites with various electrical conductive compositions, are formulated into desirable anodes. The anodes can be effectively combined into lithium ion batteries with high capacity cathode materials. In some formulations, supplemental lithium can be used to stabilize cycling as well as to reduce effects of first cycle irreversible capacity loss. Batteries are described with surprisingly good cycling properties with good specific capacities with respect to both cathode active weights and anode active weights. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/196512 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/122 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) Original (OR) Class H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/386 (20130101) H01M 4/483 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/583 (20130101) H01M 4/624 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) H01M 10/0569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290952 | Vanderburgh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathleen E. Vanderburgh (San Mateo, California); Francesco Fornasiero (Oakland, California); Jianchao Ye (Tracy, California) |
| ABSTRACT | Carbon nanotube (CNT) forests are grown directly on a base material for an anode. The CNTs are filled with Li metal. The filling behavior of the CNTs with Li metal is governed by the density, height, and diameter of the CNTs in the forest. These parameters are controlled by modifying the chemical vapor deposition (CVD) recipe used to grow the CNT forest along with adjusting the catalyst stack design to tune the aspect ratio, density, and rigidity of the CNT forest. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694030 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/06 (20130101) C23C 16/26 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/0404 (20130101) H01M 4/0428 (20130101) H01M 4/625 (20130101) Original (OR) Class H01M 4/661 (20130101) H01M 4/663 (20130101) H01M 4/1395 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230292632 | Harris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles Thomas Harris (Albuquerque, New Mexico); Sueli Del Carmen Skinner Ramos (Albuquerque, New Mexico); William F. Kindel (Albuquerque, New Mexico); Rupert M. Lewis (Albuquerque, New Mexico); Matt Eichenfield (Albuquerque, New Mexico) |
| ABSTRACT | Josephson junctions are the main circuit element of superconducting quantum information devices due to their nonlinear inductance properties and fabrication scalability. However, large scale integration necessarily depends on high fidelity and high yielding fabrication of Josephson junctions. The standard Josephson junction technique depends on a submicron suspended resist Dolan bridge that tends to be very fragile and fractures during the fabrication process. The present invention is directed to a new tunnel junction resist mask that incorporates stress-relief channels to reduce the intrinsic stress of the resist, thereby increasing the survivability of the Dolan bridge during device processing, resulting in higher Josephson junction yield. |
| FILED | Thursday, March 09, 2023 |
| APPL NO | 18/119366 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Electric solid-state devices not otherwise provided for H10N 60/12 (20230201) Original (OR) Class H10N 60/805 (20230201) H10N 60/855 (20230201) H10N 60/0912 (20230201) H10N 69/00 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230284598 | Buccafusca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HiveTech Solutions Inc. (Wilmington, Delaware) |
| ASSIGNEE(S) | HiveTech Solutions Inc. (Wilmington, Delaware) |
| INVENTOR(S) | Osvaldo Buccafusca (Fort Collins, Colorado); Kimberly A. Drennan (Boulder, Colorado); Chelsea Cook (Phoenix, Arizona); Daniel Rubenstein (Boulder, Colorado) |
| ABSTRACT | A mobile enclosure system includes a container and subsystems, including at least one of: a heating unit, a cooling unit, a humidity control unit, and a gas/vapor input unit. The system also includes sensors for monitoring environmental conditions within the container and generating environmental data, and a control unit connected with the subsystems and the sensors. The container includes a mobile foundation and a structural envelope on top of the mobile foundation. The control unit is configured for tracking power consumption by the plurality of subsystems coupled with the container, receiving the environmental data from the plurality of sensors, and modifying at least one operating parameter of the plurality of subsystems in accordance with the environmental data. In embodiments, the structural envelope is a permanent structure or includes insulated panels configured for repeated assembly and disassembly. The system may be compatible with multiple add-on packages for different applications. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200454 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 47/06 (20130101) Original (OR) Class A01K 51/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230284641 | MCHUGH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); UNIVERSITY OF CALIFORNIA AT BERKELEY (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | TARA H. MCHUGH (ALBANY, California); CRISTINA BILBAO-SAINZ (ALBANY, California); MATTHEW J. POWELL-PALM (BOZEMAN, Montana); BORIS RUBINSKY (EL CERRITO, California) |
| ABSTRACT | Fruits and vegetables are impregnated with ascorbic acid impregnation fluids during an isochoric freezing process. The ascorbic acid impregnation fluids are infused into the void pores of fruits and vegetables, without destroying cellular tissue. The infusion of ascorbic acid can prevent browning of fruits and vegetable products, increase the products' vitamin C content, and inhibit microbial growth. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692784 |
| CURRENT CPC | Preserving, e.g by Canning, Meat, Fish, Eggs, Fruit, Vegetables, Edible Seeds; Chemical Ripening of Fruit or Vegetables; the Preserved, Ripened, or Canned Products A23B 7/10 (20130101) Original (OR) Class A23B 7/055 (20130101) A23B 7/154 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 19/03 (20160801) A23L 33/15 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287330 | Talaat |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adel M. Talaat (Madison, Wisconsin) |
| ABSTRACT | Described herein is a mycobacterium mutant, comprising at least one mutation in at least one gene sequence encoding global gene regulators (GGRs) selected from the group consisting of sigH, sigL, sigE, ECF-1, and mixtures thereof, wherein the GGR gene is at least partially inactivated. Described herein also is a vaccine based on the mutant and a method of differentiating between subjects that have been infected with mycobacterium and subjects that have not been infected with mycobacterium or have been vaccinated with a mycobacterium vaccine. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/320834 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/04 (20130101) A61K 2039/522 (20130101) Peptides C07K 14/35 (20130101) C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class C12N 1/36 (20130101) C12N 15/1031 (20130101) C12N 15/1136 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5695 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287340 | Oatley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington State University (Pullman, Washington) |
| ASSIGNEE(S) | Washington State University (Pullman, Washington) |
| INVENTOR(S) | Jon Michael Oatley (Pullman, Washington); Melissa Joan Oatley (Pullman, Washington) |
| ABSTRACT | This disclosure provides improved method, kits, and systems and for isolating and enriching spermatogonial stem cells (SSCs) from livestock animal testicular tissue. In one aspect, the disclosure provides a method for enriching SSCs from a population of testis-derived cells containing at least one SSC, where the method comprises contacting the population of testis-derived cells to a culture media comprising, or that is preconditioned with, endothelial feeder cells, and maintaining culture conditions suitable for SSC cell maintenance and enrichment. In some embodiments, the media and culture conditions comprise one or more growth factors selected from GDNF, FGF2, SDF-1a, CSF-1, FDGF, NGF, and TGF-β, in any combination. In exemplary embodiments, the SSCs are porcine or bovine SSCs. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 18/006009 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/061 (20130101) Original (OR) Class C12N 2501/13 (20130101) C12N 2501/15 (20130101) C12N 2501/21 (20130101) C12N 2501/22 (20130101) C12N 2501/115 (20130101) C12N 2502/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287443 | OIKAWA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AFINGEN, INC. (Emeryville, California) |
| ASSIGNEE(S) | AFINGEN, INC. (Emeryville, California) |
| INVENTOR(S) | Ai OIKAWA (Emeryville, California) |
| ABSTRACT | The present invention provides compositions and methods for generating transgenic plants with increased plant growth and improved multiple yield-related traits, which comprise vascular xylem tissue-targeting overexpression of transcription factors (TFs) involved in vascular xylem cell development. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172699 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8223 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290145 | Chaterji et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Somali Chaterji (West Lafayette, Indiana); Saurabh Bagchi (est Lafayette, Indiana); Ran Xu (West Lafayette, Indiana) |
| ABSTRACT | A system may receive video information. The system may select a combination of light-weight features and heavy weight features. The light-weight features may be extracted from the video information and the heavy weight features not extracted. The system may forecast, based on the light-weight features and the heavy weight features, accuracy, and latency metrics for performing the object detection and tracking using a plurality of candidate branch configurations, respectively. The system may select a branch configuration from the plurality of candidate branch configurations in response to satisfaction of an optimization criterion. The system may perform object detection and tracking based on the selected branch configuration. |
| FILED | Friday, March 10, 2023 |
| APPL NO | 18/120285 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/20 (20130101) Image or Video Recognition or Understanding G06V 20/46 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230284811 | Hills et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seth R. Hills (Richmond, Virginia); GARRETT S. BULLOCK (Tuscaloosa, Alabama) |
| ABSTRACT | An apparatus for assisting a user in donning a shoe is disclosed. The apparatus can have a body defining a U-shaped receptacle that is configured to extend across an upper surface of the shoe. The body can have a pair of legs that extend downwardly on respective sides of the body to respective lower edges. The body can have a highest portion opposite the lower edges of the pair of legs that is spaced from the lower edges of the legs by at least 2 inches along a vertical axis. The apparatus can further have a clip that is coupled to the body, the clip comprising an arm that is pivotable relative to the body. The arm can define a first clamping surface. A second clamping surface can face the first clamping surface. The first and second clamping surfaces can receive the tongue therebetween. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/182541 |
| CURRENT CPC | Household or Table Equipment A47G 25/82 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285217 | Dillard |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ebony Starlyn Dillard (Aiken, South Carolina) |
| ABSTRACT | A device for controlling aspects of ambulatory (walking) gait control during physical therapy uses magnetic bodies, one worn on each ankle of the user. The magnet polarity of each body facing toward the median plane of the user is the same, and thus the magnetic bodies repel one another when in proximity to prevent the feet from crossing over one another during the swing phase of the walking gait and thereby reduce the potential for falls due to tripping. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/104823 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 3/00 (20130101) Original (OR) Class A61H 2003/007 (20130101) A61H 2201/1642 (20130101) A61H 2205/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285416 | Ren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Durect Corporation (Cupertino, California); Virginia Commonwealth University (Richmond, Virginia); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shunlin Ren (Richmond, Virginia); Yaping Wang (Richmond, Virginia); WeiQi Lin (Emerald Hills, California); James E. Brown (Los Gatos, California); Terrence Blaschke (Stanford, California) |
| ABSTRACT | Aspects of the present disclosure include methods for treating at least one of insulin resistance, diabetes, and prediabetes, and, optionally, also non-alcoholic steatohepatitis (NASH). In practicing the subject methods, an effective amount of at least one compound selected from 25-hydroxycholesterol-3-sulfate (25HC3S), 25- hydroxycholesterol-disulfate (25HCDS), 27-hydroxycholesterol-3-sulfate (27HC3S), 27- hydroxycholesterol-disulfate (27HCDS), 24-hydroxycholesterol-3-sulfate (24HC3S), 24- hydroxycholesterol-disulfate (24HCDS), and 24,25-epoxycholesterol-3-sulfate, or salt thereof is administered to the subject. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 18/008588 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/575 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287507 | Jiang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Jiang (Ellicott City, Maryland) |
| ABSTRACT | The present invention provides a method of predicting whether a pulmonary nodule in a subject is benign or non-small cell lung cancer, comprising obtaining the results of an assay that measures an expression level of miR205-5p in a plasma sample from the subject; obtaining the results of an assay that measures an expression level of miR126 in a plasma sample from the subject; obtaining the results of an assay that provides a size of the pulmonary nodule in the subject; and calculating a probability value based on the combination of the expression levels of miR205-5p and miR126, and the size of the pulmonary nodule, wherein if the probability value exceeds a specified threshold, the pulmonary nodule is predicted as non-small cell lung cancer. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992668 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2525/207 (20130101) C12Q 2561/113 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230291143 | SHIRE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States as represented by the Department of Veterans Affairs (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Bourne SHIRE (Cleveland, Ohio); Dustin J. TYLER (Cleveland, Ohio); Janet L. GBUR (Cleveland, Ohio) |
| ABSTRACT | An inline implantable connector device can provide an increased volume density to medical device systems in a limited volume. The inline implantable connector device can have a claim-shell design with a first half and a second half, each having a conductive path in a same design. The second half is turned and flipped by 180 degrees to mate with the first half so that the conductive paths interconnect to form electrical and mechanical interconnections that are fundamentally transverse to the direction of the incoming or outgoing lead wires. A first screw hole on a top side of the connector device can accept a screw therethrough; and a second screw hole on a bottom side of the connector device can accept another screw therethrough. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 18/015357 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/375 (20130101) Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/621 (20130101) Original (OR) Class H01R 24/58 (20130101) H01R 2201/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230284851 | Krasnobaev |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vivonics, Inc. (Bedford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonid Krasnobaev (Framingham, Massachusetts) |
| ABSTRACT | A particle collection system and method including a collection inlet aimable at a surface from which particles are to be collected, and a rotatable fixture including at least a pair of nozzles about the collection inlet also aimable at the surface and fluidly connected to a source of compressed fluid in order to dislodge particles from the surface. The rotatable fixture is rotated to generate, as the nozzles rotate about the collection inlet, a vortex dislodging and picking up particles on the surface, entraining the particles, and carrying the particles to the collection inlet. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/174841 |
| CURRENT CPC | Domestic Washing or Cleaning; Suction Cleaners in General A47L 9/0416 (20130101) A47L 9/1666 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230285699 | Locke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James P. Locke (Houston, Texas); Holly P. Newton (Houston, Texas); Mark E. Schaefbauer (Houston, Texas); Molly E. Harwood (Houston, Texas) |
| ABSTRACT | Presented are manual ventilator systems, methods for making/using such ventilator systems, and clamshell, accordion-style ventilators operable by a lone operator. A ventilator device includes first and second panels pivotably attached together in a clamshell configuration. Each panel has an inlet port, an outlet port, and an internal channel that fluidly connects the inlet and outlet ports. A one-way valve is fluidly connected to the first panel’s outlet port and restricts airflow therethrough in one direction. Another one-way valve is fluidly connected to the second panel’s inlet port and restricts airflow therethrough in an opposite direction. A concertinaed bellows is fluidly connected to the first panel’s outlet port and the second panel’s inlet port. The bellows is sandwiched between and attached to the two panels such that pivoting the panels away from each other expands and fills the bellows whereas pivoting the panels towards each other compresses and evacuates the bellows. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/999875 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0075 (20130101) Original (OR) Class A61M 16/208 (20130101) A61M 2205/071 (20130101) A61M 2205/8281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287065 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fuzhong Zhang (St. Louis, Missouri); Christopher H. Bowen (St. Louis, Missouri); Bin Dai (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to systems and methods for synthesizing a spidroin. In some embodiments, the methods comprise synthesizing a monomer in vivo in a heterologous host, the monomer comprising an N-terminus IntC domain and a C-terminus IntN domain, and post-translationally polymerizing the synthesized monomer via in vitro split-intein mediated polymerization. |
| FILED | Thursday, April 27, 2023 |
| APPL NO | 18/308301 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/05 (20190201) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2089/00 (20130101) B29K 2995/0088 (20130101) Peptides C07K 14/43518 (20130101) Original (OR) Class C07K 2319/21 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/70 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 1/02 (20130101) D01D 5/06 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230287443 | OIKAWA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AFINGEN, INC. (Emeryville, California) |
| ASSIGNEE(S) | AFINGEN, INC. (Emeryville, California) |
| INVENTOR(S) | Ai OIKAWA (Emeryville, California) |
| ABSTRACT | The present invention provides compositions and methods for generating transgenic plants with increased plant growth and improved multiple yield-related traits, which comprise vascular xylem tissue-targeting overexpression of transcription factors (TFs) involved in vascular xylem cell development. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172699 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8223 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290276 | BURAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TIENOVIX, LLC (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. BURAS (Friendswood, Texas); Craig S. RUSSELL (League City, Texas); Kyle Q. NGUYEN (League City, Texas) |
| ABSTRACT | Methods for providing real-time, three-dimensional (3D) augmented reality (AR) feedback guidance to a user of an equipment system for training or improved performance, including comparing sensed, real-time user positioning data and data received from the equipment system during use to reference positioning and procedure outcome data, and generating and providing to a user real-time position-based and outcome-based 3D AR feedback based on comparing the sensed and reference data. |
| FILED | Wednesday, May 17, 2023 |
| APPL NO | 18/318769 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/52 (20130101) A61B 8/085 (20130101) A61B 8/466 (20130101) A61B 8/467 (20130101) A61B 8/4245 (20130101) A61B 8/4254 (20130101) A61B 8/4263 (20130101) A61B 34/20 (20160201) A61B 90/361 (20160201) A61B 2090/365 (20160201) Optical Elements, Systems, or Apparatus G02B 27/017 (20130101) Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/016 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/065 (20130101) G09B 23/286 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230288200 | EKHOLM |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Woods Hole Oceanographic Institution (Woods Hole, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander K. EKHOLM (Falmouth, Massachusetts) |
| ABSTRACT | A device and method of using same having an inertial measurement unit (IMU), a controller, an activator, and an absolute position sensor configured to measure fluid-body waves. The controller calculates its orientation in a relative frame using data obtained from the IMU and fixed-point arithmetic. The controller transforms the relative orientation information into absolute units using data obtained from the absolute sensor and fixed-point arithmetic, producing wave measurements. The controller may then select a subset of wave measurements for transmission via an optional communications mechanism to a remote user. |
| FILED | Saturday, March 11, 2023 |
| APPL NO | 18/120365 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/004 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230290891 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng Wu (Cambridge, Massachusetts); Joerg Appenzeller (West Lafayette, Indiana) |
| ABSTRACT | A cross-coupled tunnel diode (XTD) device with large peak-to-valley current ratio (PVCR) is disclosed. A memory cell circuit comprising XTD devices is also disclosed. The XTD device includes an N-type semiconductor coupled to a P-type semiconductor. A first gate is disposed on the N-type semiconductor and a second gate is disposed on the P-type semiconductor. The first gate is coupled to the output terminal, which is further coupled to the P-type semiconductor. The second gate is coupled to the input terminal, which is coupled to the N-type semiconductor. As reverse bias voltage increases, band-to-band tunneling from valence band to conduction band initially generates increasing current, but the rising bias voltage closes the band to band tunneling window, creating a gated negative differential resistance behavior. The current drops off as the bias voltage further increases. In some examples, a ratio of peak-to-valley current ratio may exceed 103 or 105. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690417 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/11 (20130101) H01L 29/88 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230292016 | ZHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenqi ZHU (Vienna, Virginia); Amit Kumar AGRAWAL (Rockville, Maryland); Lu CHEN (Gaithersburg, Maryland); Henri J. LEZEC (Silver Spring, Maryland) |
| ABSTRACT | A chiral light-field optical imaging camera incorporating an array of photonic spin-multiplexed bifocal metalenses. Combined with a novel deep learning-based neural network reconstruction algorithm, the system provides distinct aberration-free photographic capabilities, including the ability to achieve a polarization controllable extremely large depth-of-field optical imaging across a range of distances within a range covering at least five orders of magnitude in absence of moving a part of the camera and based on a single exposure of an optical detector while maintaining high spatial lateral resolution. |
| FILED | Friday, March 10, 2023 |
| APPL NO | 18/181966 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 13/232 (20180501) H04N 23/55 (20230101) H04N 23/957 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230287596 | Kanatzidis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercouri G. Kanatzidis (Wilmette, Illinois); Wenwen Lin (Willowbrook, Illinois) |
| ABSTRACT | Methods for purifying reaction precursors used in the synthesis of inorganic compounds and methods for synthesizing inorganic compounds from the purified precursors are provided. Also provided are methods for purifying the inorganic compounds and methods for crystallizing the inorganic compounds from a melt. γ and X-ray detectors incorporating the crystals of the inorganic compounds are also provided. |
| FILED | Wednesday, April 26, 2023 |
| APPL NO | 18/139605 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 15/00 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/40 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 9/04 (20130101) C30B 11/00 (20130101) C30B 13/06 (20130101) C30B 13/34 (20130101) C30B 23/06 (20130101) C30B 35/007 (20130101) Original (OR) Class Measurement of Nuclear or X-radiation G01T 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20230288457 | VABNICK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Federal Bureau of Investigation (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America as represented by the Federal Bureau of Investigation, Dept. of Justice (Washington, District of Columbia) |
| INVENTOR(S) | Ian B. VABNICK (Fredericksburg, Virginia); Michael MALONE (Quantico, Virginia) |
| ABSTRACT | Circuit test devices and methods are provided. The method includes measuring a voltage between first and second conductor points (CPs) of a circuit under test (CUT), and determining if the measured voltage is less than a low voltage threshold value (LVTV) indicative of electrical continuity (EC) between the first and second CPs. In response to determining that the measured voltage is less than the LVTV, the method includes: transmitting a test signal (TS) to the first or second CP, and determining if the test signal is received after being transmitted. In response to determining that the TS is received, a presence of EC between the first and second conductor points is reported, and in response to determining that the TS is not received, absence of EC between the first and second CPs, or a lack of electrical contact between the VMC and the first and/or second CP(s), is reported. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/071415 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 19/16504 (20130101) Original (OR) Class G01R 19/16528 (20130101) G01R 31/54 (20200101) G01R 31/58 (20200101) G01R 31/3277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Geospatial Intelligence Agency (NGA)
| US 20230289936 | Breish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DIGITAL CHECK CORP. (NORTHBROOK, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kurt Breish (Garden Valley, Idaho); Torin Ford (Boise, Idaho) |
| ABSTRACT | Image stitching from multiple line scanners may be provided by selecting, at a plurality of times while progressing a film roll from a supply reel to a take-up reel, overlap areas on the film roll between first and second field of views of a first and second line scan sensors that read first and second data streams from the film roll; calculating, at each time, a difference measure between the first and second data streams in a current overlap area for a current time; adjusting, based on the difference measure, a size or a position of the overlap area for use at a subsequent time as the film roll progresses such that the current overlap area has a first number of pixels and a subsequent overlap area has a second number of pixels; and blending the first and second data streams at the current time at the current overlap area. |
| FILED | Monday, May 15, 2023 |
| APPL NO | 18/197551 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 7/0002 (20130101) G06T 7/97 (20170101) G06T 2207/10008 (20130101) G06T 2207/20221 (20130101) G06T 2207/20224 (20130101) Pictorial Communication, e.g Television H04N 1/00665 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20230291419 | Yoder |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore James Yoder (White Plains, New York) |
| ABSTRACT | Techniques regarding quantum error correction are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a maximum-likelihood decoder component that executes a maximum-likelihood decoding algorithm to determine an error correction based on a decoding hypergraph that characterizes error-sensitive events associated with a quantum error-correcting code executed on a quantum circuit. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/654545 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 13/01 (20130101) H03M 13/09 (20130101) H03M 13/1125 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230289599 | Sidhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tesla, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harsimran Singh Sidhu (Fremont, California); Paras Jagdish Jain (Cupertino, California); Daniel Paden Tomasello (Los Altos Hills, California); Forrest Nelson Iandola (San Jose, California) |
| ABSTRACT | A model training and implementation pipeline trains models for individual embedded systems. The pipeline iterates through multiple models and estimates the performance of the models. During a model generation stage, the pipeline translates the description of the model together with the model parameters into an intermediate representation in a language that is compatible with a virtual machine. The intermediate representation is agnostic or independent to the configuration of the target platform. During a model performance estimation stage, the pipeline evaluates the performance of the models without training the models. Based on the analysis of the performance of the untrained models, a subset of models is selected. The selected models are then trained and the performance of the trained models are analyzed. Based on the analysis of the performance of the trained models, a single model is selected for deployment to the target platform. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/183515 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) G05D 1/0214 (20130101) G05D 1/0221 (20130101) G05D 2201/0213 (20130101) Electric Digital Data Processing G06F 9/45533 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, September 14, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
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THE PANEL
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FUNDED BY
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Department of Health and Human Services (HHS)
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Army Research Office (ARO)
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APPLICANT(S) and ASSIGNEES
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Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
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ABSTRACT
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FILED
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APPL NO
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ART UNIT
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3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
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CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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