FedInvent™ Patent Applications
Application Details for Thursday, September 21, 2023
This page was updated on Wednesday, September 27, 2023 at 05:37 PM GMT
Department of Health and Human Services (HHS)
| US 20230292689 | MOEHS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arcadia Biosciences, Inc. (Davis, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHARLES PAUL MOEHS (Seattle, Washington); William J. Austill (Seattle, Washington); Dayna Loeffler (Seattle, Washington); Jessica Mullenberg (Seattle, Washington) |
| ABSTRACT | Plants with reduced gluten grains and compositions thereof are disclosed herein. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/062364 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/06 (20130101) A01H 5/10 (20130101) A01H 6/4678 (20180501) Original (OR) Class Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 7/198 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Peptides C07K 14/415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293000 | Amirana et al. |
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| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia); 460Medical, Inc. (Weston, Massachusetts) |
| ASSIGNEE(S) | The George Washington University (, None); 460Medical, Inc. (Weston, Massachusetts) |
| INVENTOR(S) | Omar Amirana (Cambridge, Massachusetts); Kenneth C. Armstrong (Cary, North Carolina); Matthew W. Kay (Kensington, Maryland); Marco A. Mercader (Arlington, Virginia); Terrance J. Ransbury (Chapel Hill, North Carolina); Narine Sarvazyan (Potomac, Maryland) |
| ABSTRACT | Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099480 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/00009 (20130101) A61B 1/043 (20130101) Original (OR) Class A61B 1/00045 (20130101) A61B 1/00082 (20130101) A61B 1/00186 (20130101) A61B 1/0638 (20130101) A61B 1/0676 (20130101) A61B 1/0684 (20130101) A61B 5/004 (20130101) A61B 5/0044 (20130101) A61B 5/0084 (20130101) A61B 5/1459 (20130101) A61B 5/6853 (20130101) A61B 5/14503 (20130101) A61B 5/14546 (20130101) A61B 18/00 (20130101) A61B 18/1492 (20130101) A61B 90/30 (20160201) A61B 90/35 (20160201) A61B 90/361 (20160201) A61B 2034/301 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293053 | Stevens et al. |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Kelly Rose Stevens (Seattle, Washington); Chelsea Fortin (Seattle, Washington); Colleen O'Connor (Seattle, Washington) |
| ABSTRACT | Systems, materials, and methods for making and using in vivo screening and highly parallel tissue grafting assay arrays are described. An implantable assay array may include a biocompatible substrate. The biocompatible substrate may define a number of mutually isolated microcompartments. The number of mutually isolated microcompartments may be determined based at least in part on a size of the implantable assay array. The size of the implantable assay array may be determined based at least in part on a size of an implantation subject. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 18/006413 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4244 (20130101) A61B 5/14503 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293082 | Inan et al. |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omer T. Inan (Atlanta, Georgia); Varol Burak Aydemir (Atlanta, Georgia); James Rehg (Atlanta, Georgia); Md Mobashir Hasan Shandhi (Atlanta, Georgia) |
| ABSTRACT | Systems and methods for measuring hemodynamic parameters with wearable cardiovascular sensing. An apparatus can include one or more sensors configured to measure an electrocardiogram signal of a user and one or more seismocardiogram (SCG) signals of the user, a memory and a processing system including one or more processors operatively coupled to the memory and the one or more sensors, and configured to receive the electrocardiogram and one or more SCG signals, and generate an assessment of heart health by determining one or more hemodynamic parameters based on the signals. The invention further includes a method for non-invasively monitoring heart health of a user including receiving an electrocardiogram signal from a first sensor of a wearable device, receiving one or more SCG signals from a second sensor of the wearable device, and generating the assessment of the heart health of the user by determining the one or more hemodynamic parameters. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200393 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/332 (20210101) A61B 5/346 (20210101) Original (OR) Class A61B 5/1102 (20130101) A61B 5/02108 (20130101) A61B 5/7264 (20130101) A61B 2562/06 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293179 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of The Stevens Institute of Technology (Hoboken, New Jersey) |
| ASSIGNEE(S) | The Trustees of The Stevens Institute of Technology (Hoboken, New Jersey) |
| INVENTOR(S) | Hongjun Wang (Millburn, New Jersey); Haoyu Wang (Lyndhurst, New Jersey); Juan Wang (Shanghai, China PRC) |
| ABSTRACT | The present invention relates generally to the manufacture of conductive scaffolds of micro and/or nanofibers with the help of different printing techniques (e.g., near-field electrostatic printing, inkjet printing), such scaffolds enabling the formation of two-dimensional (2D) or three-dimensional (3D) neural networks to mimic the native counterparts. Applications of such patterned conductive scaffolds include, but are not limited to, an engineered conduit for guiding the differentiation and outgrowth of neural cells in peripheral nerve damage or in large-volume spinal cord injury under the electrical stimulation. Meanwhile, the scaffolds could also locally deliver various biomolecules in conjunction with electrical stimulation for facilitated nervous system regeneration (FIG. 1). |
| FILED | Friday, August 06, 2021 |
| APPL NO | 18/020049 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1128 (20130101) Original (OR) Class A61B 2017/00526 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) A61L 31/10 (20130101) A61L 31/14 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Printing, Duplicating, Marking, or Copying Processes; Colour Printing, B41M 5/0047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293433 | Kwon et al. |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Glen Kwon (Madison, Wisconsin); Moteza Rasoulianboroujeni (Madison, Wisconsin); Rae Hyung Kang (Madison, Wisconsin) |
| ABSTRACT | The present technology relates generally to a method of manufacture comprising: preparing at a first temperature a non-supersaturated solution comprising a micelle forming block copolymer and a drug in a polyethylene glycol (PEG) solvent; and diluting the non-supersaturated solution with water at a second temperature to form an aqueous solution comprising drug-loaded micelles without crystallization of the PEG block(s) of the block copolymer; wherein the block copolymer comprises at least one PEG block and a second biocompatible polymer block that is not PEG, the drug has a water solubility of about or less than 10 mg/mL at 25° C., and the second temperature is lower than the first temperature, but does not allow the cooled solution to become supersaturated. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/122661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Original (OR) Class A61K 31/337 (20130101) A61K 31/517 (20130101) A61K 33/244 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293434 | Olefsky et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerrold M. Olefsky (Solana Beach, California); Wei Ying (San Diego, California) |
| ABSTRACT | Compositions comprising miR-690 and methods of employing the compositions are provided. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 18/017377 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 31/7105 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/10 (20180101) A61P 5/50 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293443 | LEE |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Tong Hyon LEE (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention relates to a composition and method for combinative therapy, capable of temporarily regulating inherent dysfunctional neural processes and reducing symptoms and/or signs of neuropsychiatric disorders including, but not limited to, psychostimulant use disorder (PUD) and other substance-related additive disorders, post-traumatic stress disorder (PTSD) and other trauma- and stress-related disorders, and levodopa-induced dyskinesia (LID) and other types of dyskinesias. The present specification shows specific examples of a dosage form. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/121626 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/20 (20130101) A61K 9/48 (20130101) Original (OR) Class A61K 31/48 (20130101) A61K 31/517 (20130101) A61K 31/4178 (20130101) A61K 45/06 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/22 (20180101) A61P 25/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293448 | Iwasaki et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Akiko Iwasaki (Guilford, Connecticut); Tianyang Mao (New Haven, Connecticut); Benjamin Goldman-Israelow (New Haven, Connecticut); W. Mark Saltzman (New Haven, Connecticut); Alexandra Suberi (New Haven, Connecticut); Melanie Reschke (New Haven, Connecticut); Alexandra Piotrowski-Daspit (Wethersfield, Connecticut); Hee Won Suh (North Haven, Connecticut) |
| ABSTRACT | Compositions and methods for inducing a protective mucosal immunity against an antigen in a subject include the step of administering to a mucosal tissue an effective amount of a vaccine composition including the antigen or polynucleotide encoding an antigen associated or encapsulated within carriers such as poly(amine-co-ester) polymers in the form of particles (e.g., solid nanoparticles formed of PACE) or PACE copolymers and/or blends. Typically, the subject has previously been exposed to the antigen, for example, by administering to the same subject via a systemic or mucosal route of administration a priming antigen. In some embodiments, the polynucleotides-based vaccines are messenger RNAs encoding a viral antigen such as a coronavirus spike protein sequence, or a portion thereof. In preferred embodiments, the vaccine composition is administered intranasally. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063582 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) Original (OR) Class A61K 9/5153 (20130101) A61K 39/215 (20130101) A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293449 | DESAI et al. |
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| APPLICANT(S) | Abraxis BioScience, LLC (Summit, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neil P. DESAI (Pacific Palisades, California); Anita N. SCHMID (Berkeley Heights, New Jersey); Shihe HOU (Millington, New Jersey); Andrew KWON (Hawthorne, California) |
| ABSTRACT | The present application provides methods and compositions for treating cancer by administering a composition comprising nanoparticles that comprise an mTOR inhibitor (such as a limus drug) and a carrier protein (such as an albumin) based upon the status of one or more mTOR-activating aberration at one or more genes selected from the group consisting of TSC1, TSC2, RPS6, PTEN, TP53, RB1, ATRX, and FAT1. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/084411 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5169 (20130101) Original (OR) Class A61K 31/44 (20130101) A61K 31/436 (20130101) A61K 47/42 (20130101) A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293468 | Deng |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingming Deng (Atlanta, Georgia) |
| ABSTRACT | In certain embodiments, this disclosure relates to KRAS agonists, pharmaceutical composition, and uses in managing cancer. In certain embodiments, the KRAS agonist is 4-(4-(2-bromoacetamido)butyl)benzoic acid, salt, prodrug, or derivative thereof. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of a compound of Formula I, salt, prodrug, or derivative thereof, to a subject in need thereof, wherein, substituents are reported herein. |
| FILED | Tuesday, April 04, 2023 |
| APPL NO | 18/295674 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/195 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293474 | BRUGAROLAS et al. |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | James B. BRUGAROLAS (Irving, Texas); Haley HILL (Seattle, Washington); Tao WANG (Coppell, Texas) |
| ABSTRACT | The present disclosure provides methods of identifying patients who have partial or total resistance to HIF-2 inhibitors or who develop partial or total resistance to HIF-2 inhibitors after treatment and providing suitable treatment to these patients. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/093840 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/275 (20130101) Original (OR) Class A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/5044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293488 | Dantas et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gautam Dantas (St. Louis, Missouri); Patrick Gonzales (St. Louis, Missouri); Kevin Forsberg (St. Louis, Missouri); Mitchell Pesesky (St. Louis, Missouri); Mayland Chang (South Bend, Indiana); Shahriar Mobashery (South Bend, Indiana) |
| ABSTRACT | The present disclosure encompasses antibacterial compositions and methods of treating bacterial infections caused by resistant bacteria. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063454 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/43 (20130101) A61K 31/407 (20130101) Original (OR) Class A61K 31/424 (20130101) A61K 31/431 (20130101) A61K 31/496 (20130101) A61K 31/546 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293490 | Roy et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh- Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Sorbonne Université (Paris, France); Centre National de la Recherche Scientifque (Paris, France); INSERM(Institut National de la Sante et de la Recherche Medicale) (Paris, France) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Sorbonne Université (Paris, France); Centre National de la Recherche Scientifique (Paris, France); INSERM (Institut de la Sante er de la Recherche Medicale) (Paris, France) |
| INVENTOR(S) | Partha Roy (Pittsburgh, Pennsylvania); Lee McDermott (Pittsburgh, Pennsylvania); Abigail E. Allen (Powell, Ohio); David Koes (Pittsburgh, Pennsylvania); David M. Gau (Plum, Pennsylvania); Paul G. Francoeur (Pittsburgh, Pennsylvania); Xavier Guillonneau (Paris, France) |
| ABSTRACT | Disclosed are anti-angiogenic agents that target Pfn1:actin interaction. Also disclosed are compounds for treating ocular diseases or conditions. Further disclosed are compounds for treating cancer. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 18/019219 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4155 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293499 | RISHI et al. |
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| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia); Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ARUN K. RISHI (Troy, Michigan); NAVNATH GAVANDE (Detroit, Michigan) |
| ABSTRACT | Described herein are compositions and methods for treating cancer in a subject. The compositions include selective NF-κB inhibitor inhibitors. The methods include inhibiting the binding of CARP-1 with NEMO. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160897 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/282 (20130101) A61K 31/427 (20130101) Original (OR) Class A61K 31/704 (20130101) A61K 31/4164 (20130101) A61K 47/557 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293525 | Kanadia |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
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| INVENTOR(S) | Rahul N. Kanadia (Storrs, Connecticut) |
| ABSTRACT | A method inhibiting replication of an RNA/DNA virus in a viral host comprises contacting the viral host with a minor spliceosome inhibitor and inhibiting the replication of the RNA/DNA virus, wherein the RNA/DNA virus interacts with minor intron-containing genes (MIGs) in the viral host. Also included are methods of treating a subject having or suspected of having an RNA/DNA viral infection. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 18/006235 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/513 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1131 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293530 | EREZ et al. |
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| APPLICANT(S) | Yeda Research and Development Co. Ltd. (Rehovot, Israel); The United States of America, as Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | Yeda Research and Development Co. Ltd. (Rehovot, Israel); The United States of America, as Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Ayelet EREZ (Moshav Bnei Zion, Israel); Rom KESHET (Rehovot, Israel); Lital ADLER (Rehovot, Israel); Eytan RUPPIN (North Bethesda, Maryland); Lee Joo SANG (Seoul, South Korea) |
| ABSTRACT | An agent which increases pyrimidine to purine ration in a cell without decreasing pyrimidine synthesis for use in a method of treating a solid tumor in a subject in need thereof, optionally in combination with an immune-modulating drug. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 18/012260 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/235 (20130101) A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293538 | Zuo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| ASSIGNEE(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Zhuo Li (Omaha, Nebraska) |
| ABSTRACT | In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. Momelotinib and Fedratinib exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice when administered prophylactically. In one aspect, Momelotinib or Fedratinib can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/117852 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5377 (20130101) Original (OR) Class A61K 31/7036 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293553 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Song Li (Mars, Pennsylvania); Yixian Huang (Pittsburgh, Pennsylvania); Haozhe Huang (Pittsburgh, Pennsylvania) |
| ABSTRACT | A polymer includes a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and including a first moiety including at least one group selected for ionic interaction with a second therapeutic agent, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer. The first moiety is attached via a labile bond and is released in vivo from the polymer to provide a biologically or therapeutically active form of a first therapeutic compounds. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 18/014867 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 31/606 (20130101) Original (OR) Class A61K 31/704 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293559 | Kaar et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel L. Kaar (Lafayette, Colorado); Daniel K. Schwartz (Boulder, Colorado); Andres Felipe Chaparro Sosa (Boulder, Colorado); Sabrina Matos De Oliveira Da Silva (Sao Carlos, Brazil); Victoria Reichelderfer (Boulder, Colorado) |
| ABSTRACT | Here, the present inventors describe novel methods and compositions to reduce protein misfolding, the formation of protein aggregates, as well as the degradation of previously formed protein aggregates, for example by separating fibrils back into protofilaments. Additional aspects of the invention include therapeutic uses of lipid bilayers to rescue misfolded proteins in Alzheimer's and other protein misfolding diseases. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 18/017074 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/685 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293569 | SINCLAIR et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Metro International Biotech, LLC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. SINCLAIR (Chestnut Hill, Massachusetts); Jun Li (Brookline, Massachusetts); Karl D. Normington (Prides Crossing, Massachusetts) |
| ABSTRACT | The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+. Such modulation may be useful in methods of treating and preventing cancer, aging, cell death, radiation damage, radiation exposure, among others, may improve DNA repair, cell proliferation, cell survival, among others, and may increase the life span of a cell or protect it against certain stresses, among others. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/737541 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/706 (20130101) A61K 31/7084 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293587 | O'Malley et al. |
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| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Friday, April 14, 2023 |
| APPL NO | 18/301048 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293596 | Quarta et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marco Quarta (Palo Alto, California); Thomas A. Rando (Stanford, California) |
| ABSTRACT | Compositions and methods are provided for induction and maintenance of quiescence of stem cells. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/114861 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0658 (20130101) C12N 2500/25 (20130101) C12N 2500/90 (20130101) C12N 2501/15 (20130101) C12N 2501/34 (20130101) C12N 2501/999 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293597 | KAUSHAL |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunjay KAUSHAL (Chicago, Illinois) |
| ABSTRACT | Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/175154 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Original (OR) Class A61K 38/19 (20130101) A61K 38/195 (20130101) A61K 38/1833 (20130101) A61K 38/1866 (20130101) A61K 38/1891 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293602 | KOH et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Young KOH (Southlake, Texas); Yongbin CHOI (Dallas, Texas) |
| ABSTRACT | Methods and compositions for the treatment of cancer are provided. The compositions comprise gut bacterial lysates and/or components thereof. The method comprises administration to a subject in need thereof of a gut bacterial lysate. Also provided are methods comprising administration of a gut bacterial lysate in combination with another cancer treatment. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 18/042231 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/742 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293614 | FLOYD et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth FLOYD (Baton Rouge, Louisiana); Adam MELVIN (Baton Rouge, Louisiana) |
| ABSTRACT | This invention is directed to methods of treating disease characterized by aberrations in the ubiquitin proteasome system (UPS). |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 18/016189 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/045 (20130101) A61K 36/282 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293624 | Szeto et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell Research Foundation, Inc. (New York, New York); Institut De Recherches Cliniques De Montreal (Montreal, Canada) |
| ASSIGNEE(S) | Cornell Research Foundation, Inc. (New York, New York); Institut De Recherches Cliniques De Montreal (Montreal, Canada) |
| INVENTOR(S) | Hazel H. Szeto (New York, New York); Peter W. Schiller (Montreal, Canada); Kesheng Zhao (New York, New York) |
| ABSTRACT | The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/668744 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/03 (20130101) A61K 38/07 (20130101) Original (OR) Class Peptides C07K 5/1008 (20130101) C07K 5/1016 (20130101) C07K 5/1019 (20130101) C07K 5/1024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293635 | VAN DEN BRINK et al. |
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| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York); EVIVE BIOTECHNOLOGY (SHANGHAI) LTD (Shanghai, China PRC) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York); EVIVE BIOTECHNOLOGY (SHANGHAI) LTD (Shanghai, China PRC) |
| INVENTOR(S) | Marcel VAN DEN BRINK (New York, New York); Alan HANASH (New York, New York); Caroline LINDEMANS (Utrecht, Netherlands); Tom TANG (Shanghai, China PRC) |
| ABSTRACT | The present invention provides methods and compositions for the use of IL-22 for treating conditions of intestinal injury and inflammatory conditions such as graft vs. host disease. Specifically, IL-22 can be used to increase Intestinal Stem Cell (ISC) recovery and for enhancing immune reconstitution following allogeneic hematopoietic transplantation. In particularly preferred embodiments, the present invention provides methods of using therapeutic IL-22, including a dimeric form of IL-22, in therapeutic compositions for treating graft vs. host disease, including hepatic, thymic, gastrointestinal, or other graft vs. host disease in hematopoietic stem cell transplant patients and in patients with inflammatory intestinal conditions. |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/156016 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/20 (20130101) Original (OR) Class Peptides C07K 14/54 (20130101) C07K 16/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293642 | ZUCHNER et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Miami (Miami, Florida); University of Rochester (Rochester, New York); UCL Business LTD (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephan L. ZUCHNER (Miami, Florida); Adriana REBELO (Miami, Florida); Andrea CORTESE (London, United Kingdom); Rong Grace ZHAI (Miami, Florida); David N. HERRMANN (Rochester, New York) |
| ABSTRACT | The present disclosure relates to methods of detecting and treating inherited neuropathy. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 17/719580 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/352 (20130101) A61K 31/426 (20130101) A61K 31/428 (20130101) A61K 31/473 (20130101) A61K 31/499 (20130101) A61K 31/502 (20130101) A61K 31/517 (20130101) A61K 31/4184 (20130101) A61K 31/4188 (20130101) A61K 31/7105 (20130101) A61K 38/443 (20130101) Original (OR) Class A61K 38/465 (20130101) A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 15/86 (20130101) C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2750/14143 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 101/01014 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293654 | KURTIS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rhode Island Hospital (Providence, Rhode Island); Seattle Children's Hospital dba Seattle Children's (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan KURTIS (Providence, Rhode Island); Christian Parcher NIXON (Little Compton, Rhode Island); Dipak Kumar RAJ (Pawtucket, Rhode Island); Jennifer Frances FRIEDMAN (Providence, Rhode Island); Michal FRIED (Rockville, Maryland); Patrick Emmet DUFFY (Washington, District of Columbia) |
| ABSTRACT | The invention provides compositions and methods for preventing or reducing the severity of malaria. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154642 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 39/39575 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/445 (20130101) C07K 16/44 (20130101) C07K 16/205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293658 | FAIRMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vaxcyte, Inc. (San Carlos, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffery C. FAIRMAN (Mountain View, California); Neeraj KAPOOR (Foster City, California); Peter T. DAVEY (Foster City, California); Angie A. SEDRA (Foster City, California) |
| ABSTRACT | The present disclosure provides immunogenic compositions comprising Group A Streptococcus (GAS) polypeptide antigens and at least one polypeptide-polysaccharide conjugate. The present disclosure further provides methods of using such compositions to induce immune responses against GAS infections in subjects. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/820554 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/482 (20130101) A61K 39/092 (20130101) Original (OR) Class A61K 39/116 (20130101) A61K 39/0283 (20130101) A61K 2039/6087 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Enzymes C12Y 304/2111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293674 | Jacobs, JR. et al. |
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| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Jacobs, JR. (Pelham, New York); Betsy Herold (Rowayton, Connecticut); Joseph Dardick (Bronx, New York); Kayla A. Weiss (Bronx, New York) |
| ABSTRACT | Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, compositions and vaccines comprising such, and methods of use thereof are each provided. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/071109 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/245 (20130101) Original (OR) Class Peptides C07K 1/13 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/102 (20130101) C12N 2710/16034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293678 | Salem et al. |
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| FUNDED BY |
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| APPLICANT(S) | Aliasger K. SALEM (Coralville, Iowa); Sean M. GEARY (Iowa City, Iowa); Kareem EBEID (Iowa City, Iowa); Emad I. WAFA (Iowa City, Iowa); Rasheid SMITH (Iowa City, Iowa); University of lowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aliasger K. Salem (Coralville, Iowa); Sean M. Geary (Iowa City, Iowa); Kareem Ebeid (Iowa City, Iowa); Emad I. Wafa (Iowa City, Iowa); Rasheid Smith (Kalamazoo, Michigan) |
| ABSTRACT | A cationic nanoparticle formed of a biodegradable or biocompatible synthetic polymer and a dendrimer having a diameter of about 125 nm to 1000 nm, and methods of using the nanoparticle, e.g., for delivery of an immunogen, are provided. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 18/042276 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 39/001156 (20180801) A61K 2039/572 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293681 | Waller et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edmund K. Waller (Atlanta, Georgia); Jian-Ming Li (Atlanta, Georgia); Mohammad S. Hossain (Lilburn, Georgia) |
| ABSTRACT | Inhibition of the VIP signaling pathway with VIP antagonist is contemplated. In certain embodiments, the disclosure relates to methods of enhancing the immune response to a cell therapy comprising administering a VIP antagonist to a subject in combination with a cell. In certain embodiments, the subject is diagnosed with leukemia or lymphoma, In certain embodiments, the cell is a blood cell, bone marrow cell, leukocyte, T-cell, natural killer cell, a hematopoietic stem cell, a G-CSF mobilized or non-mobilized blood mononuclear cell. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 18/045317 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/14 (20130101) A61K 35/17 (20130101) A61K 38/04 (20130101) A61K 38/16 (20130101) A61K 38/2278 (20130101) A61K 39/245 (20130101) A61K 39/3955 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0634 (20130101) C12N 5/0647 (20130101) C12N 5/0662 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293693 | BAKHOUM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York); THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel F. BAKHOUM (New York, New York); Bassem I. ZAKI (Hanover, New Hampshire); Duane A. COMPTON (Hanover, New Hampshire) |
| ABSTRACT | Disclosed is a method for increasing susceptibility of cancer cells to ionizing radiation by delivering to the cells a radiosensitizing agent that has one of the following properties: (a) it perturbs the process of chromosome segregation thereby increasing chromosome missegregation; or (b) it is an inhibitor of an agent that promotes faithful chromosome segregation induces numeric chromosome instability in said cells and this instability is induced substantially simultaneously with or closely prior to or closely after irradiating the cells. Examples of such radiosensitizing agent include inhibitors of one or more of the following: Kif2b, MCAK, MPS1, Eg5/Kinesin-5 5, Polo-like kinase 4, MCAK, Bub1 and Hec1. Such agents specifically target proteins involved in maintaining or promoting faithful chromosome segregation. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/175433 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) A61N 2005/1098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293698 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenbin Lin (Chicago, Illinois); Kaiyuan Ni (Chicago, Illinois); Taokun Luo (Chicago, Illinois); Guangxu Lan (Chicago, Illinois) |
| ABSTRACT | Modified metal-organic framework (MOFs) are described that have surfaces with enhanced ability to coordinatively bond to or electrostatically interact with therapeutic agents, such as nucleic acids and small molecules and proteins with phosphate or carboxylate groups. Methods of providing the modified MOFs are described that include replacing strongly coordinating metal oxo cluster capping groups with weakly coordinating capping groups and/or incorporating organic bridging ligands with electron-withdrawing groups. MOFs with surface attached therapeutic agents (e.g., immunotherapeutic agents) prepared from the modified MOFs are also described, along with methods of using the MOFs as to treat cancer, e.g., via radiotherapy-radiodynamic therapy (RT-RDT), either with or without the co-administration of another therapeutic agent, such as a chemotherapeutic agent or an immunomodulator. Thus, the described methods can involve cancer immunotherapy and in situ cancer vaccination. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/927168 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 47/52 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293704 | Benoit et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danielle Benoit (Rochester, New York); Alayna E. Loiselle (Rochester, New York); Emmanuela Adjei-Sowah (Greece, New York) |
| ABSTRACT | The present invention generally relates to novel compositions and methods for promoting regeneration of injured tendon. In some aspects, the composition comprises a nanoparticle that targets specifically to injured tendon to deliver a therapeutic agent that promotes tendon regeneration. In certain aspects, the methods comprise administering to a subject in need thereof a nanoparticle that targets specifically to injured tendon to deliver a therapeutic agent that promotes tendon regeneration. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160535 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/60 (20170801) Original (OR) Class A61K 47/64 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293710 | Pasqualini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); MBrace Therapeutics, Inc. (San Diego, California) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); MBrace Therapeutics, Inc. (San Diego, California) |
| INVENTOR(S) | Renata Pasqualini (Newark, New Jersey); Wadih Arap (Newark, New Jersey); Fernanda I. Staquicini (Summit, New Jersey) |
| ABSTRACT | The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5). |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 18/052479 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6811 (20170801) Original (OR) Class A61K 47/6889 (20170801) Peptides C07K 16/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293711 | PAULSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James C. PAULSON (Del Mar, California); Landon J. EDGAR (San Diego, California); Andrew J. THOMPSON (San Diego, California); Chika KIKUCHI (San Diego, California); Brett GARABEDIAN (Del Mar, California); Xiaoshuang WANG (San Diego, California); Eleanor BASHIAN (Laguna Niguel, California) |
| ABSTRACT | The present invention provides methods for enhancing T cell activation and expansion, and methods for stimulating a T cell immune response in a subject. The methods of the invention involve the use of a targeting agent-enzyme conjugate that contains (a) a targeting moiety that specifically binds a cell surface molecule on T cells, and (b) a sialidase or enzymatically active fragment thereof. Also provided in the invention are targeting agent-enzyme conjugates that can be used in the therapeutic methods, including antibody conjugates that are formed of a sialidase and a T cell targeting antibody (e.g., an anti-PD1 antibody). |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 18/041715 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6815 (20170801) Original (OR) Class A61K 47/6849 (20170801) Peptides C07K 16/2818 (20130101) C07K 16/2896 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293722 | Vitaliano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MetaQor LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Franco Vitaliano (Boston, Massachusetts); Gordana Vitaliano (Boston, Massachusetts) |
| ABSTRACT | Compositions comprising clathrin nanoparticles and methods for treating neurological-associated disorders. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/093775 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5169 (20130101) A61K 31/27 (20130101) A61K 31/55 (20130101) A61K 31/137 (20130101) A61K 31/165 (20130101) A61K 31/195 (20130101) A61K 31/357 (20130101) A61K 31/437 (20130101) A61K 31/485 (20130101) A61K 31/496 (20130101) A61K 31/4458 (20130101) A61K 31/7076 (20130101) A61K 47/6801 (20170801) A61K 47/6891 (20170801) A61K 47/6931 (20170801) Original (OR) Class A61K 49/08 (20130101) A61K 49/085 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293729 | Ahituv et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Nadav Ahituv (San Francisco, California); Navneet Matharu (San Francisco, California) |
| ABSTRACT | Methods and compositions are provided for activating transcription in a mammalian cell. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 17/963901 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) A01K 2217/077 (20130101) A01K 2227/105 (20130101) A01K 2267/0362 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 48/0016 (20130101) A61K 48/0066 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293732 | Roy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Subhojit Roy (Madison, Wisconsin); Jichao Sun (Madison, Wisconsin) |
| ABSTRACT | Described herein are CRISPR/Cas9 constructs designed for the C-terminal truncation of human amyloid precursor protein (APP) as well as methods of making and using such a construct. |
| FILED | Wednesday, May 17, 2023 |
| APPL NO | 18/319042 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 48/0008 (20130101) A61K 48/0058 (20130101) A61K 48/0066 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/4711 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2740/16043 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293883 | Halpern et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Modular Bionics Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ian Loren Halpern (San Francisco, California); Mark William Merlo (Santa Ana, California) |
| ABSTRACT | Devices and methods for manipulating devices such as micro-scale devices are provided. The devices can include a tether of various materials surrounded by a stiff body. The tether interfaces with microscale devices to draw them against the stiff body, holding the microscale devices in a locked position for insertion into or extraction out of tissue. The tensional hook and stiff body are configurable in a multitude of positions and geometries to provide increased engagement. Such configurations allow for a range of implantation and extraction surgical procedures for the device within research and clinical settings. |
| FILED | Thursday, May 25, 2023 |
| APPL NO | 18/323826 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/068 (20130101) A61B 17/00234 (20130101) A61B 2017/00345 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0529 (20130101) Original (OR) Class A61N 1/3605 (20130101) A61N 1/36007 (20130101) A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 1/36075 (20130101) A61N 1/36082 (20130101) A61N 1/36085 (20130101) A61N 1/36089 (20130101) A61N 1/36096 (20130101) A61N 1/36107 (20130101) A61N 1/37282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293891 | KASS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David KASS (Columbia, Maryland); Gordon TOMASELLI (Lutherville, Maryland); Jonathan KIRK (Baltimore, Maryland) |
| ABSTRACT | The invention provides methods related to improving heart function. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 18/058189 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/365 (20130101) A61N 1/3627 (20130101) Original (OR) Class A61N 1/3682 (20130101) A61N 1/3684 (20130101) A61N 1/3688 (20130101) A61N 1/36507 (20130101) A61N 1/36843 (20170801) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/447 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293899 | WOODS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam J. WOODS (Gainesville, Florida); Alejandro ALBIZU (Gainesville, Florida); Ruogu FANG (Gainesville, Florida); Aprinda INDAHLASTARI (Alachua, Florida) |
| ABSTRACT | A method is provided for precision dosing of electrical stimulation of the brain. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of an electro-stimulation device including a plurality of electrodes positioned on a head of a subject. The method also includes obtaining measurements that indicate a tissue type at each voxel inside the head of the subject based on an imaging device. The method also includes determining, with a processor, a value of one or more parameters of the electro-stimulation device based on the tissue type measurements at each voxel such that the electro-stimulation device is configured to generate a value of one or more parameters of an electric field at each voxel inside the head of the subject to improve the treatment outcome of the subject. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 18/018734 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293911 | Ebbini |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emad S. Ebbini (Edina, Minnesota) |
| ABSTRACT | An ultrasound transducer array is incorporated in a light-weight, conformable, and wearable patch that may be used to deliver, monitor, and control localized transcranial focused ultrasound (tFUS). The patch may include full-duplex transmit-receive circuitry that may be used for continuous monitoring of transcranial focused ultrasound (tFUS) application. The circuitry may include a circulator. The ultrasound transducer array may be coupled to an aperture interface having irregularly sized or shaped channel conductors to provide a coarse aperture for the array. The coarse aperture may be designed using a method that provides a reduced channel count. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/117643 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4494 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/006 (20130101) A61N 2007/0026 (20130101) A61N 2007/0052 (20130101) A61N 2007/0086 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0688 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294086 | Henry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles S. Henry (Fort Collins, Colorado); Brian J. Geiss (Fort Collins, Colorado); David S. Dandy (Fort Collins, Colorado); Cody Carrell (Sun Prairie, Wisconsin); Jeremy Link (Fort Collins, Colorado); Isabelle Samper (Fort Collins, Colorado); Ana Sanchez-Cano (Fort Collins, Colorado); Ilhoon Jang (Seoul, South Korea); Zachary Call (Fort Collins, Colorado) |
| ABSTRACT | An assay device includes a colorimetric testing assembly including a detection area, a fluid inlet, and a microfluidic network including a first path extending to the detection area and a second path extending to the detection area. When a fluid (e.g., a buffer fluid or a combined buffer and sample solution) is provided to the fluid inlet, a first portion of the fluid rehydrates a first dried reagent (e.g., a dried enzyme label) disposed along the first path to produce a first rehydrated reagent and a second portion of the fluid rehydrates a second dried reagent (e.g., a dried substrate) to produce a second rehydrated reagent. The first rehydrated reagent and the second rehydrated reagent are then sequentially delivered to the detection area by capillary-driven flow to perform the assay. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 18/016753 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) Original (OR) Class B01L 3/50273 (20130101) B01L 2200/16 (20130101) B01L 2300/069 (20130101) B01L 2300/088 (20130101) B01L 2400/0406 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54388 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294090 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and (Beijing, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoguang Zhang (Beijing, China PRC); Xianhua Wang (Beijing, China PRC) |
| ABSTRACT | A sample processing and detection apparatus and an application thereof, capable of efficiently implementing the entire detection process of extraction and amplification of a sample such as a pathogen nucleic acid in a short time, being safe and convenient. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 18/010274 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 7/52 (20130101) B01L 2200/16 (20130101) B01L 2200/0689 (20130101) B01L 2300/027 (20130101) B01L 2300/044 (20130101) B01L 2300/0672 (20130101) B01L 2400/0478 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/6851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295070 | Ortlund et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Ortlund (Decatur, Georgia); Suzanne Mays (Marietta, Georgia); Nathan Jui (Decatur, Georgia); Autumn Flynn (Decatur, Georgia); Michael Dugan (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200431 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 35/50 (20130101) C07C 39/23 (20130101) C07C 43/23 (20130101) C07C 49/83 (20130101) C07C 49/683 (20130101) C07C 59/54 (20130101) Original (OR) Class C07C 215/70 (20130101) C07C 255/47 (20130101) C07C 271/34 (20130101) C07C 307/02 (20130101) C07C 309/66 (20130101) C07C 2602/22 (20170501) Heterocyclic Compounds C07D 249/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/091 (20130101) C07F 9/572 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295106 | Olson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Delix Therapeutics, Inc. (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David E. Olson (Oakland, California); Lee Dunlap (Oakland, California); Florence Wagner (Palo Alto, California); Milan Chytil (Palo Alto, California); Noel Aaron Powell (Palo Alto, California) |
| ABSTRACT | Provided herein are ergoline-derived heterocyclic compounds which can be useful for methods of treating a disease or for increasing neural plasticity. The compounds can also be useful for increasing dendritic spine density. |
| FILED | Wednesday, October 14, 2020 |
| APPL NO | 17/768725 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 209/90 (20130101) C07D 211/78 (20130101) C07D 401/04 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 471/06 (20130101) C07D 491/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295129 | LAWRENCE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas J. LAWRENCE (Lutz, Florida); Harshani Rithma LAWRENCE (Lutz, Florida); Derek DUCKETT (Land O Lakes, Florida); Gary REUTHER (Temple Terrace, Florida) |
| ABSTRACT | The present disclosure provides anti-cancer compounds and uses thereof, more particularly inhibitors of ACK1 tyrosine kinase and their use in the treatment of cancer. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 18/021308 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 403/12 (20130101) Original (OR) Class C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295136 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Indianapolis, Indiana); ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Johnson (Indianapolis, Indiana); Eli Chapman (Tucson, Arizona) |
| ABSTRACT | Novel compounds and methods of killing or inhibiting the growth of bacteria. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155399 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic or Carbocyclic Compounds C07C 251/86 (20130101) C07C 2602/10 (20170501) Heterocyclic Compounds C07D 215/12 (20130101) C07D 215/26 (20130101) C07D 215/28 (20130101) C07D 307/52 (20130101) C07D 307/73 (20130101) C07D 401/12 (20130101) C07D 405/12 (20130101) C07D 409/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295164 | GITAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey); PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL (Shenzhen, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zemer GITAI (Princeton, New Jersey); Hahn KIM (Princeton, New Jersey); James K. MARTIN (Princeton, New Jersey); Joseph P. SHEEHAN (Princeton, New Jersey); Connor CHAIN (Princeton, New Jersey); Yong HUANG (Shenzhen, China PRC); Shuo LI (Shenzhen, China PRC); Xueming CHEN (Shenzhen, China PRC); Chenran JIANG (Shenzhen, China PRC) |
| ABSTRACT | In one aspect, compounds and associated pharmaceutical compositions are described herein for the treatment of various bacterial infections and/or other diseases. In some embodiments, for example, compounds of Formula (I) and/or salts thereof are described herein. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 18/014032 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 239/95 (20130101) C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295181 | COSFORD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas David Peter COSFORD (San Diego, California); Dominik HEIMANN (Hamm, Germany); Peter TERIETE (San Diego, California); Sumit Kumar CHANDA (La Jolla, California); Lars PACHE (San Diego, California); Laurent Jean Stephane DE BACKER (San Diego, California); Nicole BATA (San Diego, California) |
| ABSTRACT | Provided herein are compounds that modulate the activity of melanoma inhibitor of apoptosis (ML-IAP) protein, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/997461 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) C07D 487/22 (20130101) C07D 498/04 (20130101) Original (OR) Class C07D 513/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295226 | Cudic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Florida Atlantic University Board of Trustees (Boca Raton, Florida); University of Florida Research Foundation (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Predrag Cudic (Boca Raton, Florida); Jay McLaughlin (Gainesville, Florida) |
| ABSTRACT | Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and/or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/167353 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 31/4045 (20130101) A61K 38/00 (20130101) A61K 47/64 (20170801) A61K 47/65 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/04 (20180101) A61P 25/06 (20180101) A61P 25/16 (20180101) A61P 25/18 (20180101) A61P 25/28 (20180101) A61P 25/36 (20180101) Peptides C07K 5/12 (20130101) Original (OR) Class C07K 7/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295238 | Jackson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cody Jackson (Palm Beach Gardens, Florida); Hyeryun Choe (Juno Beach, Florida); Michael Farzan (Juno Beach, Florida) |
| ABSTRACT | The present invention provides modified viral capsid and viral particles that contain an inserted or conjugated IR-binding agent (e.g., an IR-binding peptide). The invention also provides related polynucleotide sequences that encode such modified capsid proteins, as well as vectors for expressing the modified capsid proteins. Also provided in the invention are recombinant viral vectors or viral particles (e.g., rAAVs) having (1) a modified capsid (for non-enveloped viruses) or modified viral envelope (for enveloped viruses) that contains an inserted or conjugated IR-binding agent, and (2) a recombinant or engineered viral genome (e.g., AAV genome) that harbors a heterologous target gene or transgene sequence (e.g., a therapeutic protein encoding sequence). Further provided in the invention are methods for constructing the engineered viral vectors, and methods of using the vectors for delivering a transgene. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 18/017175 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295240 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | XIAOPING ZHU (Clarksville, Maryland); SUSAN PARK-OCHSNER (Towson, Maryland); WEIZHONG LI (College Park, Maryland) |
| ABSTRACT | Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); an influenza HA protein; and a trimerization domain. Disclosed are compositions comprising one or more of the peptides described herein. Disclosed are nucleic acid sequences capable of encoding any one of the peptides described herein. Disclosed are methods for eliciting a protective immune response against influenza comprising administering to a subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; an influenza HA protein; and a trimerization domain, wherein the administering is to a mucosal epithelium. Disclosed are methods of treating a subject exposed to influenza or at risk of being exposed to influenza comprising administering to the subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; an influenza HA protein; and a trimerization domain, wherein the administering is to a mucosal epithelium. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/163145 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/16034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295242 | Nabel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Gary J. Nabel (Chestnut Hill, Massachusetts); Srinivas Rao (Columbia, Maryland); Wataru Akahata (Kensington, Maryland) |
| ABSTRACT | The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs. |
| FILED | Wednesday, June 07, 2023 |
| APPL NO | 18/331083 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/53 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295246 | Wardenburg et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juliane Bubeck Wardenburg (St. Louis, Missouri); Brandon Lee (St. Louis, Missouri); Reuben Olaniyi (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure relates to methods and compositions useful to reduce or prevent tolerogenic or suppressive T-cell responses in a subject to a bacterial pathogen. The methods include exposing the subject to an modified bacterial antigen prior to the first exposure of the subject to the bacterial pathogen. The vaccination strategy is capable of neutralizing Hla to provide immunoprotection against S. aureus infections. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/787091 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/55 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/31 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295263 | Hagood et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Hagood (Chapel Hill, North Carolina); Simon Wong (La Jolla, California); Ronit Fraiman (Chapel Hill, North Carolina) |
| ABSTRACT | The invention relates to a soluble Thy-1 polypeptide or a functional fragment thereof and pharmaceutical compositions including the soluble Thy-1 polypeptide or a functional fragment thereof. The invention also relates to the use of the soluble Thy-1 polypeptide or a functional fragment thereof for delivery to subjects with tissue fibrosis for treating, inhibiting, and/or reversing tissue fibrosis in the subject. |
| FILED | Thursday, April 20, 2023 |
| APPL NO | 18/303796 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 14/70503 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295271 | Goodman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Myron F. Goodman (Los Angeles, California); Michael Lieber (Los Angeles, California); Phuong Pham (Los Angeles, California) |
| ABSTRACT | Methods and systems are provided to induce hypermutation, produce phage libraries displaying mutagenized immunoglobulin variable regions, and conduct affinity maturation based on the use of activation-induced deoxycytidine deaminase (AID) and a low fidelity DNA polymerase eta (pol η). High affinity monoclonal antibodies or antigen-binding fragments thereof produced by these methods are also demonstrated. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/928690 |
| CURRENT CPC | Peptides C07K 16/005 (20130101) Original (OR) Class C07K 16/40 (20130101) C07K 16/2869 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295277 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Rebecca Lim (Los Angeles, California); Liang Rong (Los Angeles, California); Jianming Xie (Los Angeles, California) |
| ABSTRACT | A universal chimeric antigen receptors (CAR)-modified immune cell is provided, including engineering natural killer (NK) cells and/or T cells which recognizes 2,4-dinitrophenyl (DNP) and can subsequently be redirected to target various epitopes of envelop protein gp160 using DNP-conjugated broad neutralizing antibodies as adaptor molecules. In preferred embodiments, the anti-gp160 antibodies target membrane-distal epitopes. This system can recognize and kill mimic HIV-infected cell lines expressing at least one of subtypes B and C gp160. Presently provided system containing universal CAR-NK cells and (bNAbs) overcome the limitations of conventional anti-HIV CARs, as the latter targets a single epitope of the HIV envelope glycoprotein gp160 and falls short of countering the enormous diversity and mutability of viruses. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 18/010910 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) Original (OR) Class C07K 16/2896 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295278 | Chan-Hui et al. |
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| FUNDED BY |
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| APPLICANT(S) | Theraclone Sciences, Inc. (Seattle, Washington); International AIDS Vaccine Initiative, Inc. (New York, New York); The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Po-Ying Chan-Hui (Bellevue, Washington); Steven Frey (Redmond, Washington); Ole Olsen (Everett, Washington); Jennifer Mitcham (Redmond, Washington); Matthew Moyle (Redmond, Washington); Sanjay K. Phogat (Frederick, Maryland); Dennis R. Burton (La Jolla, California); Laura Marjorie Walker (San Diego, California); Pascal Raymond Georges Poignard (San Diego, California); Wayne Koff (Stony Brook, New York); Melissa Danielle De Jean De St. Marcel Simek-Lemos (Brooklyn, New York); Stephen Kaminsky (Bronx, New York) |
| ABSTRACT | The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/150957 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1045 (20130101) Original (OR) Class C07K 16/1063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295308 | CHATURANTABUT et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Saireudee CHATURANTABUT (Cambridge, Massachusetts); William SELLERS (Cambridge, Massachusetts) |
| ABSTRACT | Described and featured herein are antagonistic biparatopic antibodies that specifically bind and inhibit an FGF receptor (e.g., FGFR2) and methods of using such antibodies for the treatment of cancers, including Cholangiocarcinoma (CCAs). |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 18/008108 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 35/00 (20180101) Peptides C07K 16/2863 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295317 | Debinski et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Waldemar Debinski (Winston-Salem, North Carolina); Denise Mazess Herpai (Winston-Salem, North Carolina) |
| ABSTRACT | Provided herein are monoclonal antibodies that specifically bind IL-13RA2 with cross-reactivity in humans and canines. Also provided are methods of use of the antibodies in the treatment and monitoring of cancers. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/298466 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 47/6813 (20170801) A61K 47/6829 (20170801) A61K 47/6849 (20170801) A61K 47/6851 (20170801) A61K 47/6911 (20170801) A61K 49/0004 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/2866 (20130101) Original (OR) Class C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/56 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295349 | GUO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Commonwealth University (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Youzhong GUO (Glen Allen, Virginia) |
| ABSTRACT | Provided are a Native Cell Membrane Nanoparticle (NCMN) system and methods of using the NCMN polymers to extract and/or purify one or more membrane proteins. The NCMN system includes at least one NCMN polymer and one or more membrane proteins in their native lipid bilayer membrane. A method of using the NCMN system to extract or isolate the one or more membrane proteins in the form of NCMN system without the use of a detergent while maintaining the protein’s native structure and functional activity is provided. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 18/001413 |
| CURRENT CPC | Peptides C07K 1/14 (20130101) C07K 1/36 (20130101) C07K 17/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295550 | Parchment et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Ralph E. Parchment (Frederick, Maryland); Thu A. Nguyen (Manhattan, Kansas) |
| ABSTRACT | Provided are inserts (100) for preparing a cell culture chamber(s), or array of chambers, inside of histology cassettes that are suitable for three-dimensional multicellular growth of a cell or cells into spheroids, organoids, or other 3D structures, such that the resulting 3D multi-cellular structures are ready and suitable for histology processing without transfer to a different receptacle or container. Further embodiments of the invention provide methods of preparing at least one cell culture chamber using the inserts, systems for growing three-dimensional multicellular spheroids comprising culturing cells within a cell culture chamber prepared using the inserts, and systems for analyzing at least one cultured cell in vitro comprising culturing cells within a cell culture chamber prepared using the inserts. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 18/018762 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295562 | Tedder et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas F. Tedder (Durham, North Carolina); Takashi Matsushita (Kanazawa, Japan); Yohei Iwata (Magoya, Japan); Koichi Yanaba (Tokyo, Japan); Jean-David Bouaziz (Maison-Alfort, France) |
| ABSTRACT | The present invention relates to a distinct B cell subset, B10 cells, that regulate T cell mediated inflammatory responses through the secretion of interleukin-10 (IL-10). The invention also relates to the use of B10 cells in the manipulation of immune and inflammatory responses, and in the treatment of disease. Therapeutic approaches involving adoptive transfer of B10 cells, or expansion of their endogenous levels for controlling autoimmune or inflammatory diseases and conditions are described. Ablation of B10 cells, or inhibition of their IL-10 production can be used to upregulate immunodeficient conditions, ameliorate infectious diseases and/or to treat tumors/cancer. Diagnostic applications are also encompassed. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106906 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/2803 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5052 (20130101) G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295571 | WU et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); Shriners Hospitals for Children (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHIA-LUNG WU (St. Louis, Missouri); AMANDA DICKS (St. Louis, Missouri); FARSHID GUILAK (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of compositions and methods for stem cell chondrogenesis. An aspect of the present disclosure provides for a method of differentiating pluripotent stem cells (e.g., induced pluripotent stem cells (iPSCs), human induced pluripotent stem cells (hiPSCs)) into chondrocyte-like cells (e.g., cartilage). |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/796579 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0655 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295573 | Athanasiou et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyriacos A. Athanasiou (Irvine, California); Jerry C. Hu (Irvine, California); Wendy Evelyn Brown (Irvine, California); Ryan Patrick Donahue (Irvine, California) |
| ABSTRACT | Engineered neocartilage tissue compositions comprising human rib cartilage-derived cells at passage 5 (P5) or greater and methods for producing said engineered neocartilage tissue compositions. The engineered neocartilage tissue compositions are scaffold-free and feature the use of highly expanded cells exhibiting functional properties similar to native articular cartilage. The human rib cartilage-derived cells may be allogeneic cells. The tissue compositions herein may be configured for surgical implantation. The tissue compositions may be configured to repair a variety of tissues and defects such as, but not limited to, hyaline cartilage, fibrocartilage, elastic cartilage, chondral lesions, osteochondral lesions, osteoarthritic conditions, a temporomandibular joint (TMJ) disc complex, TMJ tissues, a knee meniscus, nasal cartilages, facet cartilages, knee articular cartilage, ear cartilage, or a combination thereof. |
| FILED | Thursday, May 25, 2023 |
| APPL NO | 18/323667 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0655 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295582 | MOSER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FluGen, Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | FluGen, Inc. (Madison, Wisconsin) |
| INVENTOR(S) | Michael J. MOSER (Madison, Wisconsin); Yasuko HATTA (Madison, Wisconsin); Pamuk BILSEL (Madison, Wisconsin); Lindsay HILL-BATORSKI (Lodi, Wisconsin) |
| ABSTRACT | The invention provides an influenza virus that demonstrates enhanced growth in Vero cells. The influenza virus includes PA, NP, and NS gene segments having selected nucleotides and encoding proteins having amino acid sequences with selected amino aids. The invention also provides a pharmaceutical formulation containing the influenza virus, as well as a method of eliciting an immune response in a mammal by administering the influenza virus to the mammal, and a method for generating the influenza virus. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 18/017374 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/522 (20130101) Peptides C07K 14/11 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295615 | Cheng et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert Cheng (Unionville, Connecticut); Nathaniel Jillette (Farmington, Connecticut) |
| ABSTRACT | The invention described herein provides compositions and reagents for integrating large sequences (e.g., 150 bp or more) into a selected target DNA sequence via prime editing. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 18/040939 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295626 | PLACE et al. |
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| FUNDED BY |
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| APPLICANT(S) | miRecule, Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert PLACE (Gaithersburg, Maryland); Anthony SALEH (Gaithersburg, Maryland); Tishan WILLIAMS (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155163 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 47/549 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/33 (20130101) C12N 2310/141 (20130101) C12N 2310/316 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/351 (20130101) C12N 2310/531 (20130101) C12N 2310/3521 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) C12N 2320/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295629 | Brown, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert H. Brown, Jr. (Needham, Massachusetts); Jonathan K. Watts (Worcester, Massachusetts); Helene Tran (Shrewsbury, Massachusetts); Michael Moazami (Worcester, Massachusetts) |
| ABSTRACT | The present disclosure provides antisense compounds, methods, and compositions for silencing C9ORF72 transcripts. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with C9ORF72 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with C9ORF72. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178206 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/3231 (20130101) C12N 2310/3341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295631 | Saleh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland); miRecule, Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland); miRecule, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Anthony D. Saleh (Potomac, Maryland); Carter Van Waes (Brookeville, Maryland); Zhong Chen (Bethesda, Maryland); Hui Cheng (Falls Church, Virginia) |
| ABSTRACT | Disclosed herein are methods of treating a tumor in a subject, including administering to the subject one or more miRNA nucleic acids or variants (such as mimics or mimetics) thereof with altered expression in the tumor. Also disclosed herein are compositions including one or more miRNA nucleic acids. In some examples, the miRNA nucleic acids are modified miRNAs, for example, and miRNA nucleic acid including one or more modified nucleotides and/or a 5′-end and/or 3′-end modification. In particular examples, the modified miRNA nucleic acid is an miR-30a nucleic acid. Further disclosed herein are methods of diagnosing a subject as having a tumor with altered expression of one or more miRNA nucleic acids. In some embodiments, the methods include detecting expression of one or more miRNAs in a sample from the subject and comparing the expression in the sample from the subject to a control. |
| FILED | Friday, April 14, 2023 |
| APPL NO | 18/301040 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 45/06 (20130101) A61K 47/6849 (20170801) A61K 47/6913 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/315 (20130101) C12N 2310/346 (20130101) C12N 2320/32 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295632 | Bresnick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emery H. Bresnick (Middleton, Wisconsin); Noboyuki Tanimura (Kita-Ku, Japan) |
| ABSTRACT | A method of controlling red blood cell production includes contacting red blood cell precursors with a composition including a zinc chelator, a composition including an inhibitor of a zinc importer protein, or a combination thereof; wherein the contacting inhibits survival of the red blood cell precursors, inhibits terminal differentiation of the red blood cell precursors to mature red blood cells, or a combination thereof. |
| FILED | Friday, April 21, 2023 |
| APPL NO | 18/304694 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 33/30 (20130101) A61K 35/18 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0641 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/122 (20130101) C12N 2310/531 (20130101) C12N 2501/90 (20130101) C12N 2501/999 (20130101) C12N 2506/03 (20130101) C12N 2506/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295642 | Patel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| ASSIGNEE(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| INVENTOR(S) | Smita S. Patel (Piscataway, New Jersey); Laura C. Johnson (Piscataway, New Jersey); Gayatri Patel (Basking Ridge, New Jersey); Anupam Singh (Piscataway, New Jersey) |
| ABSTRACT | Compositions and methods for rapid and efficient Toehold mediated strand displacement (TMSD) reactions are disclosed. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160774 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295653 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Prashant G. Mali (La Jolla, California); Luhan Yang (Somerville, Massachusetts) |
| ABSTRACT | A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner. |
| FILED | Thursday, April 06, 2023 |
| APPL NO | 18/296579 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/01 (20130101) C12N 15/10 (20130101) C12N 15/63 (20130101) C12N 15/81 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 15/87 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) C12N 15/1024 (20130101) C12N 15/8201 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) C12N 2810/55 (20130101) Enzymes C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295659 | Deverman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin E. Deverman (Pasadena, California); Viviana Gradinaru (La Canada Flintridge, California); Ken Y. Chan (Pasadena, California) |
| ABSTRACT | Disclosed herein are peptide sequences capable of directing adeno-associated viruses (AAV) to target specific environments, for example the nervous system and the heart, in a subject. Also disclosed are AAVs having non-naturally occurring capsid proteins comprising the disclosed peptide sequences, and methods of using the AAVs to treat diseases. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/047233 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/08 (20130101) Peptides C07K 7/06 (20130101) C07K 14/005 (20130101) C07K 14/015 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2320/32 (20130101) C12N 2330/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295668 | TRUONG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Opentrons Labworks Inc. (Brooklyn, New York); New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Minh TRUONG (Brooklyn, New York) |
| ABSTRACT | Provided herein are methods and compositions for integrating a large DNA construct into a genome in a cell. Also provided herein are methods and compositions for producing a synthetic genome. |
| FILED | Friday, March 17, 2023 |
| APPL NO | 18/185601 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295686 | Kennedy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Kennedy (Seattle, Washington); Jesse J. Salk (Seattle, Washington); Michael Hipp (Seattle, Washington); Elizabeth Schmidt (Seattle, Washington); Rosa Ana Risques (Seattle, Washington); Daniela Nachmanson (Seattle, Washington) |
| ABSTRACT | The present technology relates generally to methods and compositions for targeted nucleic acid sequence enrichment, as well as uses of such enrichment for error-corrected nucleic acid sequencing applications. In some embodiments, highly accurate, error corrected and massively parallel sequencing of nucleic acid material is possible using a combination of uniquely labeled strands in a double-stranded nucleic acid complex in such a way that each strand can be informatically related to its complementary strand, but also distinguished from it following sequencing of each strand or an amplified product derived therefrom. In various embodiments, this information can be used for the purpose of error correction of the determined sequence. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/933058 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) C12Q 2521/501 (20130101) C12Q 2525/191 (20130101) C12Q 2531/113 (20130101) C12Q 2535/119 (20130101) C12Q 2535/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295688 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155623 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295691 | PERSSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Henrik H.J. PERSSON (Palo Alto, California); Roxana JALILI (Palo Alto, California); Joseph L. HORECKA (Stanford, California); Ronald W. DAVIS (Palo Alto, California) |
| ABSTRACT | Provided herein is a circular proximity ligation assay in which proximity-probes are employed as bridges to connect two free oligonucleotides via a dual ligation event, resulting in the formation of a circle. The circles are then quantified by, e.g., qPCR. The addition of an extra oligonucleotide is believed to enhance specificity by decreasing the probability of random background ligation events. In addition, circle formation may have selective advantages, as uncircularized DNA can be removed by a simple exonuclease treatment and it has streamlined the workflow by eliminating preamplification prior to qPCR. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 18/050071 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Original (OR) Class C12Q 1/6851 (20130101) C12Q 2521/501 (20130101) C12Q 2523/307 (20130101) C12Q 2531/125 (20130101) C12Q 2537/162 (20130101) Enzymes C12Y 605/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295695 | Hart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Marie Hart (Cambridge, Massachusetts); Xiao Wang (Cambridge, Massachusetts); Mark Bathe (Cambridge, Massachusetts); Gabriela S. Schlau-Cohen (Cambridge, Massachusetts); Jiajia Guo (Changchun, China PRC) |
| ABSTRACT | Disclosed are nucleic acid-chromophores and nucleic acid assembly containing the nucleic acid-chromophores. The nucleic acid-chromophore contains a nucleic acid strand and two or more adjacent chromophores. The two or more adjacent chromophores can be covalently incorporated in the backbone of the nucleic acid strand. One or more photophysical properties of the adjacent chromophores can be altered by a change in the nucleic acid assembly. In some forms, the nucleic acid assembly can contain a nucleic acid scaffold. In these forms, the change in the nucleic acid assembly can be a change in the length of a nucleic acid hybrid in the nucleic acid scaffold that is opposite the adjacent chromophores. Typically, the nucleic acid hybrid does not contain any chromophore. The nucleic acid-chromophores can serve as molecular fluorophores with emission properties that are highly sensitive to local geometry and the chemical environment. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051344 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6832 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295697 | CAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Long CAI (Pasadena, California); Eric LUBECK (Pasadena, California); Timur ZHIYENTAYEV (Pasadena, California); Ahmet COSKUN (Pasadena, California); Ting-Fang HE (Pasadena, California); Chang Ho SOHN (Pasadena, California); Sheel SHAH (Pasadena, California) |
| ABSTRACT | The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940650 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 2201/10 (20130101) G01N 2201/068 (20130101) Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295717 | Phillips et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Phillips (Salt Lake City, Utah); Jennifer M. Heemstra (Salt Lake City, Utah) |
| ABSTRACT | Branching phosphoramidite monomers and molecules having comb-like structures are disclosed and described. A branching phosphoramidite monomer having the structure is provided wherein R4 and R5 are independently —(O—CH2—CH2—)n where n is 1-5 or —O—(CH2—)n where n is 1-10, and R1, R2, and R3 are each one of dimethoxytrityl (DMT)-O—, levulinyl (Lev)-O—, and a phosphoramidite. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/963119 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6816 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295730 | Lenardo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Moldova) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Lenardo (Bethesda, Maryland); Helen Su (Bethesda, Maryland); Ahmet Oguzhan Ozen (Istanbul, Turkey); Williams Andrew Comrie (Rockville, Maryland); Kaan Boztug (Vienna, Austria); Rico Chandra Ardy (Vienna, None) |
| ABSTRACT | Disclosed herein are methods of diagnosing, and treating and/or preventing CD55-deficiency, hyperactivation of complement, angiopathic thrombosis and protein-losing enteropathy (CHAPLE). The method of diagnosing includes: providing a sample from a patient; performing an assay detecting at least one of at least one mutation in a DNA sequence of a CD55 gene, at least one mutation in a RNA sequence of a CD55 transcript, at least one mutation in a DNA sequence of a CD55 complementary-DNA (cDNA), CD55 protein, CD55 protein binding, complement deposition or combination thereof, and diagnosing the patient with CHAPLE. The method of treating and/or preventing at least one symptom of CHAPLE includes: administering an effective amount of a composition comprising at least one complement inhibitor to a subject in need thereof, wherein the composition is effective in treating or preventing at least on symptom of CHAPLE. The disclosure further relates to compositions effective at treating and/or preventing CHAPLE. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154745 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) Peptides C07K 16/40 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6851 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295736 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Xiaole Liu (Wayland, Massachusetts); Peng Jiang (Boston, Massachusetts) |
| ABSTRACT | The present invention relates to gene expression signatures that predict response and resistance to targeted therapy and immunotherapy. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 18/047910 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295743 | Driebe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (Phoenix, Arizona); ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (Flagstaff, Arizona); CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Driebe (Flagstaff, Arizona); Jolene Bowers (Flagstaff, Arizona); David Engelthaler (Flagstaff, Arizona); Paul Keim (Flagstaff, Arizona); Brandi Limbago (Atlanta, Georgia); James K. Rasheed (Atlanta, Georgia); Linda McDougal (Atlanta, Georgia); Valerie S. Albrecht (Atlanta, Georgia) |
| ABSTRACT | The present invention provides a method of detecting Staphylococcus aureus in a subject, by contacting a sample obtained from the subject with at least one detectably labeled probe of the invention or detecting in the sample identity to a sequence of the invention. The invention is also directed to kits, microarrays and detectable Staphylococcus aureus polynucleotide probes useful in detecting the presence of Staphylococcus aureus. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/165310 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/505 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 2531/113 (20130101) C12Q 2561/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295749 | Alland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | David Alland (Bernardsville, New Jersey); Padmapriya P. Banada (Edison, New Jersey); Salvatore A.E. Marras (Roselle Park, New Jersey) |
| ABSTRACT | This disclosure provides an improved assay capable of identifying and distinguishing viral variants, such as SARS-CoV-2 variants and subvariants, including Alpha, Beta, Gamma, Delta, and Omicron, with high specificity and sensitivity. The disclosed assay can be used for real-time monitoring of viral variants (e.g., SARS-CoV-2 variants) spread without the need for whole-genome sequencing on all samples. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154427 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296528 | JABBARZADEH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | EHSAN JABBARZADEH (COLUMBIA, South Carolina); SARA ESLAMBOLCHIMOGHADAM (COLUMBIA, South Carolina) |
| ABSTRACT | Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections. |
| FILED | Thursday, May 25, 2023 |
| APPL NO | 18/323552 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14539 (20130101) A61B 2562/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/80 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296563 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shujie Yang (Durham, North Carolina); Tony Jun Huang (Durham, North Carolina) |
| ABSTRACT | Technologies for harmonic acoustic manipulation of colloidal particles include a system having a piezoelectric substrate coupled to one or more segmented acoustic transducers and a fluid positioned above the substrate. The segmented transducers have multiple segments, each with a resonant frequency equal to a harmonic frequency. The system further includes a controller that generates a harmonic signal including multiple harmonic components and applies the signal to the segmented acoustic transducers to generate an acoustic potential field in the fluid and manipulate the colloidal particles. The system may translate or rotate the particles, and may form the particles into a colloidal crystal monolayer. The system may selectively pair or otherwise group and separate individual particles. The system may pair and separate multiple groups of particles. The system may measure adhesion between particles. The system may pattern particles over a surface. The colloidal particles may be cells. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/120679 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/022 (20130101) Original (OR) Class G01N 29/036 (20130101) G01N 29/2437 (20130101) G01N 2291/0423 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/02559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296590 | Kshitiz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kshitiz (Farmington, Connecticut); Junaid Afzal (Farmington, Connecticut); Wenqiang Du (Farmington, Connecticut); Yasir Suhail (Farmington, Connecticut) |
| ABSTRACT | Disclosed are constructs and methods to accelerate maturation of human pluripotent stem cell derived cardiomyocytes by maintaining them on a Cardiac Mimetic Matrix (CMM) substrate. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/184851 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2500/38 (20130101) C12N 2501/33 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2535/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296626 | Keane et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Miami (Miami, Florida) |
| ASSIGNEE(S) | University of Miami (Miami, Florida) |
| INVENTOR(S) | Robert W. Keane (Miami, Florida); Dalton W. Deitrich (Miami, Florida); Juan Pablo de Rivero Vaccari (Miami, Florida); Helen M. Bramlett (Miami, Florida) |
| ABSTRACT | Compositions and methods for detecting components of the inflammasome in a sample from a subject as markers for inflammasome-related diseases or disorders such as multiple sclerosis, stroke, mild cognitive impairment, Alzheimer's disease, age-related macular degeneration, NASH, inflammaging or traumatic brain injury. Methods of using such inflammasome markers to determine prognosis, direct treatment and monitor response to treatment for the subject with an inflammasome-related disease or disorder such as multiple sclerosis, stroke, mild cognitive impairment, Alzheimer's disease, age-related macular degeneration, NASH, inflammaging or traumatic brain injury are also described. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/921600 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 16/18 (20130101) C07K 2317/24 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 33/6896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296627 | TRAVIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander J.A. TRAVIS (Ithaca, New York); Roy COHEN (Ithaca, New York) |
| ABSTRACT | The present invention relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay according to the present invention that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the biomarker in the sample. The present invention also relates to methods of determining the state of a subject's neural injury. The present invention also relates to systems and devices useful in carrying out the methods of the present invention. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971081 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/18 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/25 (20130101) C12Q 1/32 (20130101) C12Q 1/42 (20130101) C12Q 1/66 (20130101) C12Q 1/485 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/2814 (20130101) G01N 2800/2821 (20130101) G01N 2800/2835 (20130101) G01N 2800/2857 (20130101) G01N 2800/2871 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296628 | Axtell et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oklahoma Medical Research Foundation (Oklahoma City, Oklahoma); The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Axtell (Oklahoma City, Oklahoma); Kumar Gaurav (Oklahoma City, Oklahoma); Agnieshka Agasing (Orlando, Florida) |
| ABSTRACT | The present invention includes a method of predicting and/or treating a recurrence of MS treating a patient with multiple sclerosis, the method comprising: obtaining a hematopoietic cell sample from a patient suspected of having a recurrence of multiple sclerosis (MS), wherein the patient was in relapse for MS; determining the number of CD19+, CD24+, CD38+ transitional B cells in the hematopoietic cell sample, and a level of expression of neurofilament light (NFL) and interleukin-1β (IL-1β), which is predictive of a recurrence of MS; and treating the MS patient with recurrence until there is an increase in CD19+, CD24+, CD38+ transitional B cells and/or a decrease in a level of expression of NFL and interleukin-1β (IL-1β) when compared to an untreated MS control sample, an unresponsive MS control sample, or an MS patient with long-term stable disease sample. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 18/004479 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 33/56972 (20130101) G01N 2333/545 (20130101) G01N 2333/70596 (20130101) G01N 2800/52 (20130101) G01N 2800/54 (20130101) G01N 2800/285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296635 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Shaopeng WANG (Chandler, Arizona); Zijian WAN (Tempe, Arizona); Heng ZHU (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods of determining binding kinetics of a ligand. In some embodiments, the methods include contacting the ligand with a first surface of a substrate, which first surface comprises an electrically conductive coating and a population of virions connected to the first surface via one or more linker moieties, wherein viral envelopes of the virions display one or more proteins that bind, or are capable of binding, to the ligand, applying an alternating current electric field to the substrate to induce the virions to oscillate proximal to the first surface of the substrate, and detecting changes in oscillation amplitudes of the virions over a duration. Related virion oscillator array devices, systems and computer readable media are also provided. |
| FILED | Friday, March 17, 2023 |
| APPL NO | 18/185808 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/94 (20130101) Original (OR) Class G01N 33/54373 (20130101) G01N 2021/6439 (20130101) G01N 2333/035 (20130101) G01N 2333/726 (20130101) G01N 2500/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296708 | Annio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Siemens Healthcare GmbH (Erlangen, Germany); Centre National de la Recherche Scientifique (CNRS) (Paris, France); Institut National de La Sante et de la Recherche Medicale (INSERM) (Paris, France); King's College London (London, United Kingdom); Department of Health and Human Services (Bethesda, Maryland); Univ Paris XIII Paris-Nord Villetaneuse (Villetaneuse, France); Universite de Paris (Paris, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giacomo Annio (Mola Di Bari Ba, Italy); Verena Muller-Reinwald (Bayern, Germany); Ralph Sinkus (Parmain, France); Omar Darwish (London, United Kingdom); Wilfried Schnell (Forchheim, Germany); Tamara Elisabeth Falkner (Schwabach, Germany); Ahmed M. Gharib (Bethesda, Maryland) |
| ABSTRACT | The present disclosure is directed to a motor for a magnetic resonance (MR) tomography room, to a patient table for the MR room, to a MR elastography device, and to a MR tomography device. A MR tomography device for a MR elastography imaging protocol is arranged within the MR tomography room, and includes a rotational drive for supplying rotational energy to power a MR elastography transducer usable during the MR elastography imaging protocol, and a support structure. The rotational drive comprises a terminal for connecting the MR elastography transducer to the rotational drive, and a bearing means configured such that the position of the terminal relative to the support structure is adaptable along a trajectory predetermined by the bearing means. The rotational drive is mounted to the support structure via the bearing means. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697492 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 6/0487 (20200801) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296709 | TAMIR et al. |
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| FUNDED BY |
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| APPLICANT(S) | Subtle Medical, Inc. (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan TAMIR (Menlo Park, California); Srivathsa PASUMARTHI VENKATA (Menlo Park, California); Tao ZHANG (Menlo Park, California); Enhao GONG (Menlo Park, California) |
| ABSTRACT | Methods and systems are provided for improving model robustness and generalizability. The method may comprise: acquiring, using a medical imaging apparatus, a medical image of a subject; reformatting the medical image of the subject in multiple scanning orientations; applying a deep network model to the medical image to improve the quality of the medical image; and outputting an improved quality image of the subject for analysis by a physician. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/174339 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5601 (20130101) G01R 33/5608 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 3/60 (20130101) G06T 5/50 (20130101) G06T 2207/10088 (20130101) G06T 2207/20084 (20130101) G06T 2207/20216 (20130101) G06T 2207/30004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230297838 | Chakrabartty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shantanu Chakrabartty (St. Louis, Missouri); Darshit Mehta (St. Louis, Missouri) |
| ABSTRACT | An analog memory device includes a first node and a second node. The first node includes a first floating gate, a second floating gate, and a capacitor. The first node first floating gate is connected to the first node second floating gate via the capacitor. The second node includes a first floating gate, a second floating gate, and a capacitor. The second node first floating gate is connected to the second node second floating gate via the capacitor. The second node is connected to the first node, and an analog state of the first node and an analog state of the second node continuously and synchronously decay with respect to time. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 18/042230 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Original (OR) Class G06N 3/0464 (20230101) Static Stores G11C 27/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298696 | SIROTA et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marina SIROTA (Belmont, California); Dmitry RYCHKOV (Fremont, California) |
| ABSTRACT | The disclosure generally relates to methods of selecting a biomarker associated with a disorder or disease, and computer program products and systems for performing such methods. The disclosure further relates to biomarkers for rheumatoid arthritis and methods of use such biomarkers. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 18/017650 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 2600/158 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298702 | ALT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Frederick W. ALT (Cambridge, Massachusetts); Jiazhi HU (Boston, Massachusetts); Sherry LIN (Brookline, Massachusetts); Zhou DU (Chestnut Hill, Massachusetts); Yu ZHANG (West Roxbury, Massachusetts); Huan CHEN (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are methods and assays for detection of recombination and/or rearrangement events in a cell. In some embodiments, the methods and/or assays relate to Linear Amplification Mediated (LAM)-PCR. In some embodiments, the recombination event is a V(D)J recombination event. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/129274 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6827 (20130101) C12Q 1/6855 (20130101) C12Q 1/6858 (20130101) C12Q 1/6869 (20130101) C12Q 2549/119 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 30/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230292913 | PINKOS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vorbeck Materials Corp. (Jessup, Maryland) |
| ASSIGNEE(S) | Vorbeck Materials Corp. (Jessup, Maryland) |
| INVENTOR(S) | JENNIFER PINKOS (Hanover, Maryland); Keren Espina (Randallstown, Maryland); James Turney (Silver Spring, Maryland); Can Gun Yaprak (Halethorpe, Maryland); Christie Burrow (New Market, Maryland) |
| ABSTRACT | Various wearable communications pouches (“WCP”) having modular and static antenna elements of reduced visual signature are provided. The WCP demountably couples to the shoulder straps of articles, garments, and baggage items. The WCP includes a front panel and shoulder strap(s) pivotably coupled to opposite sides of a back panel. The back panel includes a communications hub that has antenna ports that are each conductively coupled to an antenna element or antenna attachment site. Each antenna attachment site receives a demountable antenna element. The antenna element and demountable antenna element include a conductive composition that includes a polymer and graphene sheets present as a percolated network therein. The back panel includes a fastener positioned proximate to the hub that receives and secures a portable radio. The front panel, back panel, and shoulder strap each include a RF shielding material to shield the user from RF radiation that emanates from the WCP. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696562 |
| CURRENT CPC | Travelling or Camp Equipment: Sacks or Packs Carried on the Body A45F 3/02 (20130101) Original (OR) Class A45F 2003/003 (20130101) Antennas, i.e Radio Aerials H01Q 1/273 (20130101) H01Q 1/526 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293490 | Roy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh- Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Sorbonne Université (Paris, France); Centre National de la Recherche Scientifque (Paris, France); INSERM(Institut National de la Sante et de la Recherche Medicale) (Paris, France) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Sorbonne Université (Paris, France); Centre National de la Recherche Scientifique (Paris, France); INSERM (Institut de la Sante er de la Recherche Medicale) (Paris, France) |
| INVENTOR(S) | Partha Roy (Pittsburgh, Pennsylvania); Lee McDermott (Pittsburgh, Pennsylvania); Abigail E. Allen (Powell, Ohio); David Koes (Pittsburgh, Pennsylvania); David M. Gau (Plum, Pennsylvania); Paul G. Francoeur (Pittsburgh, Pennsylvania); Xavier Guillonneau (Paris, France) |
| ABSTRACT | Disclosed are anti-angiogenic agents that target Pfn1:actin interaction. Also disclosed are compounds for treating ocular diseases or conditions. Further disclosed are compounds for treating cancer. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 18/019219 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4155 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293538 | Zuo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| ASSIGNEE(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Zhuo Li (Omaha, Nebraska) |
| ABSTRACT | In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. Momelotinib and Fedratinib exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice when administered prophylactically. In one aspect, Momelotinib or Fedratinib can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/117852 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5377 (20130101) Original (OR) Class A61K 31/7036 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293587 | O'Malley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Friday, April 14, 2023 |
| APPL NO | 18/301048 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293698 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenbin Lin (Chicago, Illinois); Kaiyuan Ni (Chicago, Illinois); Taokun Luo (Chicago, Illinois); Guangxu Lan (Chicago, Illinois) |
| ABSTRACT | Modified metal-organic framework (MOFs) are described that have surfaces with enhanced ability to coordinatively bond to or electrostatically interact with therapeutic agents, such as nucleic acids and small molecules and proteins with phosphate or carboxylate groups. Methods of providing the modified MOFs are described that include replacing strongly coordinating metal oxo cluster capping groups with weakly coordinating capping groups and/or incorporating organic bridging ligands with electron-withdrawing groups. MOFs with surface attached therapeutic agents (e.g., immunotherapeutic agents) prepared from the modified MOFs are also described, along with methods of using the MOFs as to treat cancer, e.g., via radiotherapy-radiodynamic therapy (RT-RDT), either with or without the co-administration of another therapeutic agent, such as a chemotherapeutic agent or an immunomodulator. Thus, the described methods can involve cancer immunotherapy and in situ cancer vaccination. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/927168 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 47/52 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293721 | Delehanty et al. |
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| FUNDED BY |
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| APPLICANT(S) | US Department of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James B. Delehanty (Washington, District of Columbia); Megan Muroski (Alexandria, Virginia); Eunkeu Oh (Washington, District of Columbia); Jeffrey R. Deschamps (Laurel, Maryland) |
| ABSTRACT | A nanoparticle (NP)-peptide conjugate provides efficient steric hindrance/blockage of cellular membrane potassium (K+) channels to mediate depolarization of cellular membrane potential. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/170229 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/17 (20130101) A61K 47/52 (20170801) A61K 47/6929 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293816 | Gholami |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Autonomous Healthcare, Inc. (Hoboken, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Behnood Gholami (Menlo Park, California) |
| ABSTRACT | The present disclosure describes a closed-loop fluid resuscitation and/or cardiovascular drug administration system that uses continuous measurements and adaptive control architecture. The adaptive control architecture uses a function approximator to identify unknown dynamics and physiological parameters of a patient to compute appropriate infusion rates and to regulate the endpoint of resuscitation. |
| FILED | Tuesday, May 23, 2023 |
| APPL NO | 18/321847 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/3569 (20130101) A61M 2230/00 (20130101) A61M 2230/06 (20130101) A61M 2230/30 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294603 | Dwyer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oshkosh Corporation (Oshkosh, Wisconsin) |
| ASSIGNEE(S) | Oshkosh Corporation (Oshkosh, Wisconsin) |
| INVENTOR(S) | Kevin Dwyer (Oshkosh, Wisconsin); Isaiah Kronebusch (Oshkosh, Wisconsin); Steven Carstens (Oshkosh, Wisconsin); Ethan Ensign (Oshkosh, Wisconsin); Joshua Murman (Oshkosh, Wisconsin); James Doering (Oshkosh, Wisconsin); Ben Wellens (Oshkosh, Wisconsin); Luke Gustafson (Oshkosh, Wisconsin) |
| ABSTRACT | A control system for a military vehicle includes processing circuitry configured to obtain a weight, an incline, a brake air supply pressure, a current gear, and a transaxle range of the military vehicle. The processing circuitry is also configured to determine a minimum brake air supply pressure for the military vehicle based on the weight, the incline, the current gear, and the transaxle range of the military vehicle. The processing circuitry is also configured to compare the brake air supply pressure to the minimum brake air supply pressure, and, in response to the brake air supply pressure being less than the minimum brake air supply pressure, operate a display of the military vehicle to provide an alarm to an operator of the military vehicle to notify the operator that the brake air supply pressure is less than the minimum brake air supply pressure. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698423 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 35/00 (20130101) B60K 2370/12 (20190501) B60K 2370/152 (20190501) B60K 2370/178 (20190501) Arrangement of Signalling or Lighting Devices, the Mounting or Supporting Thereof or Circuits Therefor, for Vehicles in General B60Q 5/005 (20130101) B60Q 9/00 (20130101) Original (OR) Class Vehicle Brake Control Systems or Parts Thereof; Brake Control Systems or Parts Thereof, in General; Arrangement of Braking Elements on Vehicles in General; Portable Devices for Preventing Unwanted Movement of Vehicles; Vehicle Modifications to Facilitate Cooling of Brakes B60T 17/22 (20130101) B60T 2210/20 (20130101) B60T 2250/00 (20130101) B60T 2250/02 (20130101) B60T 2270/88 (20130101) B60T 2270/406 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294644 | Del Gizzi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Stratom, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Del Gizzi (Arvada, Colorado); Broc Sommermeyer (Windsor, Colorado); Kristin Farris (Arvada, Colorado); Zachary Allen (Superior, Colorado); Ross Wehner (Erie, Colorado); Mark Gordon (Lafayette, Colorado) |
| ABSTRACT | Systems and techniques are provided for autonomous or semi-autonomous connection and disconnection of an end effector to a port, such as a refueling port associated with a fuel tank. The end effector may be coupled with a carriage system, such as a robotic arm and have a connection with a supply source. A sensor suite may be coupled with the carriage system and output optical and/or proximity data that is received at a controller system. The controller system may identify a location of the port, position the end effector in proximity with the port, and provide a connection therebetween. The controller system may identify a fiducial target associated with the port that provides for alignment with the end effector and port. The end effector may also include a compensation system to adjust a location of the end effector to a finer degree than is possible using the carriage system. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/700425 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1697 (20130101) Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 5/02 (20130101) Original (OR) Class Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295093 | Iacono et al. |
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| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott T. Iacono (Colorado Springs, Colorado); Chadron M Friesen (Langley, Canada) |
| ABSTRACT | The present invention relates to a mechanochemical based synthesis of perfluoropyridine monomers, polymers made using such monomers and methods of making and using articles comprising such polymers. Such perfluoropyridine monomers are easily chemically tuned have the strength needed for high temperature applications and the flexibility needed for low temperature applications. In addition, to the aforementioned monomers, a mechanochemical based synthesis for such perfluoropyridine monomers is provided. All of the aforementioned performance application advantages are also found in polymers comprising Applicants' perfluoropyridine monomers. |
| FILED | Friday, May 26, 2023 |
| APPL NO | 18/202352 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/61 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0627 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 71/00 (20130101) Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 147/04 (20130101) C10M 169/041 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2050/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295284 | Hynes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Richard O. Hynes (Winchester, Massachusetts); Karl Dane Wittrup (Chestnut Hill, Massachusetts); Noor Jailkhani (Cambridge, Massachusetts); Noor Momin (Cambridge, Massachusetts); Emi Lutz (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are anti-FN-EIIIB nanobodies, conjugates thereof, and methods of using the nanobodies and conjugates thereof. |
| FILED | Tuesday, January 31, 2023 |
| APPL NO | 18/162512 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6813 (20170801) A61K 47/6843 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/55 (20130101) C07K 14/56 (20130101) C07K 14/57 (20130101) C07K 14/525 (20130101) C07K 14/565 (20130101) C07K 14/5412 (20130101) C07K 14/5421 (20130101) C07K 14/5428 (20130101) C07K 14/5434 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/569 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295552 | Chiou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Pei-Yu E. Chiou (Los Angeles, California); Tianxing Man (Los Angeles, California) |
| ABSTRACT | In various embodiments, a Laser-actuated Supercritical Injector (LASI) is provided. This device provides high-speed fluidic jet injection into biological samples, such as cells, organs, and tissues (including skin). In certain embodiments the LASI devices exploit high-speed fluidic jets that are pushed by rapid bubble expansion in a fluid. The bubbles are formed when liquid confined in microcavities or holes are heated up to above the supercritical temperature of the fluid. This leads to the formation of a short but ultra-high vapor pressure (supercritical) fluid that ejects the fluid (and any cargo contained therein) out through microchannels. This jet penetrates a cell, organ or tissue juxtaposed to a surface containing the microchannels and the jet provide sufficient force to penetrate into the cell, tissue, or organ leading to effective deliver of a cargo. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 18/019080 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0622 (20151001) B23K 26/0648 (20130101) Apparatus for Enzymology or Microbiology; C12M 35/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295560 | SHAMOO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Yousif SHAMOO (Houston, Texas); Heer MEHTA (Houston, Texas); Ramya Ganiga PRABHAKAR (Bangalore, India); Seokju SEO (Houston, Texas) |
| ABSTRACT | The present disclosure is directed to composition and methods for use in drug screening methods. The identification of microbial strains producing antibiotics effective against multi-drug resistant bacterial pathogens using microfluidics and co-encapsulation of predator and prey strains permits rapid and multiplexed assessment of new antibiotics for emerging bacterial pathogens including those resistant to multiple existing antibiotics. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 18/054714 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/145 (20210501) C12N 1/205 (20210501) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/465 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295613 | Jewett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. Jewett (Evanston, Illinois); Joongoo Lee (Evanston, Illinois); Jeffrey S. Moore (Savoy, Illinois); Kevin J. Schwarz (Champaign, Illinois) |
| ABSTRACT | Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/904211 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 2310/353 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295680 | Mershin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Andreas Mershin (Cambridge, Massachusetts); Katarzyna Paulina Adamala (Minneapolis, Minnesota) |
| ABSTRACT | Synells are created by encapsulating components and iteratively optimizing each synell for a desired trait. Each synell is tested during each interation. Failed synells are discarded. Additional synell components are added during each iteration, with iterative optimization being repeated until synells having the trait are created. A method for synell reproduction includes creating a synell having a desired trait, determining a recipe for the synell, digitizing the recipe, and transmitting the digitized recipe to another location. The recipe is reconstituted at the other location and the synell is reproduced using the recipe. On-demand biosynthesis of synells includes generating droplets containing different synell components within a microfluidic device, fusing them into combinations, and storing them until a request for a synell having a particular trait is received. Fused droplets having the component combination for the trait, or being combinable to produce it, are retrieved and encapsulated to form the requested synell. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/866455 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295686 | Kennedy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Kennedy (Seattle, Washington); Jesse J. Salk (Seattle, Washington); Michael Hipp (Seattle, Washington); Elizabeth Schmidt (Seattle, Washington); Rosa Ana Risques (Seattle, Washington); Daniela Nachmanson (Seattle, Washington) |
| ABSTRACT | The present technology relates generally to methods and compositions for targeted nucleic acid sequence enrichment, as well as uses of such enrichment for error-corrected nucleic acid sequencing applications. In some embodiments, highly accurate, error corrected and massively parallel sequencing of nucleic acid material is possible using a combination of uniquely labeled strands in a double-stranded nucleic acid complex in such a way that each strand can be informatically related to its complementary strand, but also distinguished from it following sequencing of each strand or an amplified product derived therefrom. In various embodiments, this information can be used for the purpose of error correction of the determined sequence. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/933058 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) C12Q 2521/501 (20130101) C12Q 2525/191 (20130101) C12Q 2531/113 (20130101) C12Q 2535/119 (20130101) C12Q 2535/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295695 | Hart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Marie Hart (Cambridge, Massachusetts); Xiao Wang (Cambridge, Massachusetts); Mark Bathe (Cambridge, Massachusetts); Gabriela S. Schlau-Cohen (Cambridge, Massachusetts); Jiajia Guo (Changchun, China PRC) |
| ABSTRACT | Disclosed are nucleic acid-chromophores and nucleic acid assembly containing the nucleic acid-chromophores. The nucleic acid-chromophore contains a nucleic acid strand and two or more adjacent chromophores. The two or more adjacent chromophores can be covalently incorporated in the backbone of the nucleic acid strand. One or more photophysical properties of the adjacent chromophores can be altered by a change in the nucleic acid assembly. In some forms, the nucleic acid assembly can contain a nucleic acid scaffold. In these forms, the change in the nucleic acid assembly can be a change in the length of a nucleic acid hybrid in the nucleic acid scaffold that is opposite the adjacent chromophores. Typically, the nucleic acid hybrid does not contain any chromophore. The nucleic acid-chromophores can serve as molecular fluorophores with emission properties that are highly sensitive to local geometry and the chemical environment. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051344 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6832 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295842 | Weisenberger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Weisenberger (Lexington, Kentucky); John Craddock (Lexington, Kentucky) |
| ABSTRACT | Methods to produce a polyacrylonitrile-based carbon fiber and polyacrylonitrile-based carbon fiber fabric with physical characteristic closely resembling rayon-based carbon fibers are disclosed. A polyacrylonitrile-based carbon fiber and polyacrylonitrile-based carbon fiber fabric with a unique combination of physical properties are also disclosed. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/073432 |
| CURRENT CPC | Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/225 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/12 (20130101) D10B 2401/04 (20130101) D10B 2401/06 (20130101) D10B 2403/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295978 | Chapla et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin M. Chapla (Melissa, Texas); Catherine Trent (Allen, Texas) |
| ABSTRACT | Disclosed herein is a panel assembly configured to form a mullion joint. The panel assembly can comprise a panel composed of a material substrate that, in some examples, can be transparent to radio frequency signals. The panel assembly can further comprise a first bezel configured to frame a perimeter of the panel on a first side of the panel. The panel assembly can comprise a second bezel configured to frame the perimeter of the panel on a second side of the panel opposite of the first side, the second bezel comprising cogs formed on a first edge of the second bezel. The cogs of the second bezel can be configured to receive and join with cogs of a bezel of a second panel assembly to form a mullion joint. The mullion joint can be transparent, opaque, or partially transparent to radio frequency signals and/or visible light. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698981 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 1/1484 (20130101) Original (OR) Class B64C 1/1492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296122 | KWIATKOWSKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRATT and MILLER ENGINEERING AND FABRICATION, LLC (NEW HUDSON, None) |
| ASSIGNEE(S) | PRATT and MILLER ENGINEERING AND FABRICATION, LLC (NEW HUDSON, Michigan) |
| INVENTOR(S) | Kevin R. KWIATKOWSKI (Ann Arbor, Michigan); Reed PELLY (New Hudson, Michigan); Aaron WARD (Charlotte, North Carolina); Steven REINI (Waterford, Michigan); Jason KREMAR (Mooresville, North Carolina) |
| ABSTRACT | A mounting structure apparatus for dynamically loaded structure joints is disclosed. The apparatus includes a first member having an aperture through a first surface and communicating with a counterbore in a second surface. A second member is included having a blind bore coaxial with the first member aperture. An insert is engageable with the counter bore, and a fastener is disclosed insertable into the first member aperture and interactive with the second member to join the first member to the second member. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/069498 |
| CURRENT CPC | Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 5/0241 (20130101) Original (OR) Class F16B 37/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296353 | PORTOGHESE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ROCCO PORTOGHESE (Winter Park, Florida); Matthew Lankford (Merritt Island, Florida) |
| ABSTRACT | A device to capture pressure data from a weapon's foregrip during live fire, the weapon having a Picatinny accessory rail, the device comprising a plurality of sensor bodies that are mountable to the Picatinny accessory rail, each sensor body having a pressure sensitive region that can capture pressure data placed on the pressure sensitive region, each sensor body having channels that correspond to the Picatinny accessory rail, retention latch system that attaches the sensor body to the weapon; and, a communication assembly that allows data communication between the plurality of sensor bodies and a computer. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699258 |
| CURRENT CPC | Smallarms, e.g Pistols, Rifles; Accessories Therefor F41C 23/16 (20130101) Weapon Sights; Aiming F41G 3/26 (20130101) Original (OR) Class F41G 11/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296380 | McBride et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sterling Eduardo McBride (Princeton, New Jersey); Alan M. Braun (Princeton, New Jersey); Seth Charles Caliga (Lafayette, Colorado) |
| ABSTRACT | An assembly includes one or more high temperature vapor cells positioned along an axis of the assembly, a vacuum envelope encasing the one or more high temperature vapor cells, and one or more sets of low thermal conductivity mounting structures coupled to the vacuum envelope. Each set of low thermal conductivity mounting structures is configured to position a corresponding one of the high temperature vapor cells within the vacuum envelope. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 18/041053 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/62 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296439 | Ng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Kin Chiu Ng (Fresno, California); Subrata Sanyal (Eastvale, California) |
| ABSTRACT | Provided is a portable biosensor that includes a sample filter cartridge, a filter collector, an optical sphere, an electromagnetic radiation emitter, a photo-detector, a processor, a signal display, a vacuum pump, and a power supply. The sample filter cartridge selectively removes small molecules to minimize spectral interference in the detection signal. The sample is concentrated onto the filter collector and subjected to illumination by the electromagnetic radiation emitter, producing Raman-scattering. The optical sphere collects and distributes the Raman-scattering shifts, which then pass through a spectral filter to produce spectral filtered scattering, which is then reflected by the concave holographic flat-field grating onto the photo-detector. The data is displayed graphically to provide the Raman-scattering shift data. The data is compared with a database for sample identification. The device is contained within a housing that is small enough to be easily transported for field use. |
| FILED | Monday, March 20, 2023 |
| APPL NO | 18/123488 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0202 (20130101) G01J 3/0227 (20130101) G01J 3/0229 (20130101) G01J 3/0272 (20130101) G01J 3/0275 (20130101) G01J 3/0286 (20130101) G01J 3/4412 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 40/1318 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296526 | Ng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Kin Chiu Ng (Fresno, California); Subrata Sanyal (Eastvale, California) |
| ABSTRACT | Provided is a portable biosensor that includes a sample filter cartridge, a filter collector, an optical sphere, an electromagnetic radiation emitter, a photo-detector, a processor, a signal display, a vacuum pump, and a power supply. The sample filter cartridge selectively removes small molecules to minimize spectral interference in the detection signal. The sample is concentrated onto the filter collector and subjected to illumination by the electromagnetic radiation emitter, producing Raman-scattering. The optical sphere collects and distributes the Raman-scattering shifts, which then pass through a spectral filter to produce spectral filtered scattering, which is then reflected by the concave holographic flat-field grating onto the photo-detector. The data is displayed graphically to provide the Raman-scattering shift data. The data is compared with a database for sample identification. The device is contained within a housing that is small enough to be easily transported for field use. |
| FILED | Monday, March 20, 2023 |
| APPL NO | 18/123679 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Original (OR) Class G01N 21/6486 (20130101) G01N 2201/0221 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296544 | Glavin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the AirForce (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Glavin (Springboro, Ohio); David C. Moore (Sellersburg, Indiana) |
| ABSTRACT | The present invention relates to real-time impedance spectroscopy using 2d transition metal dichalcogenide material-based chemical sensor systems and methods of making and using same. Impedance approach to breakdown the resistance into multiple, measureable resistance components is used in such system. Thus, a real time impedance can be used to measure the resistance of a flake network when exposed to a gas. This change in the resistance can now be used to determine the concentration of a gas of interest, in many cases, down to a parts per trillion level. Thus, gas concentrations can efficiently and effectively determined on a more accurate level and less expensively than before. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/110998 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/021 (20130101) G01N 27/026 (20130101) Original (OR) Class G01N 27/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296790 | Langel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Steven Edward Langel (Bedford, Massachusetts); John David Quartararo (Tynsgboro, Massachusetts); Joseph Samuel Cisneros (Pomona, California); Kevin Francis Greco (Hermosa Beach, California) |
| ABSTRACT | An apparatus that performs spoof detection of satellite signals based on clock information derived from the satellite signals. The apparatus may include a position, velocity, time (PVT) component that derives the clock information from the satellite signals and provides the clock information to a spoof detection mechanism. In some embodiments, the clock frequency estimate is modeled as a Wiener process. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/298917 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/11 (20130101) G01S 19/23 (20130101) G01S 19/37 (20130101) Original (OR) Class G01S 19/215 (20130101) G01S 19/243 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296956 | Datta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ipshita Datta (New York, New York); Michal Lipson (New York, New York); Sang Hoon Chae (New York, New York); James Hone (New York, New York) |
| ABSTRACT | Methods and systems are described for modulating optical signals. An example method may comprise supplying, via a waveguide, an optical signal to a resonator optically coupled to the waveguide. The method may comprise modulating a phase of the optical signal based on at least one layer comprising an electro-optic material having an electro-refractive property and an electro-absorptive property. The modulating of the phase may be based on using the at least one layer to tune a coupling of the waveguide and the resonator between being under-coupled and being over-coupled. The method may comprise outputting, via the waveguide, the modulated optical signal. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063352 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0018 (20130101) G02F 1/035 (20130101) G02F 1/2252 (20130101) Original (OR) Class G02F 2203/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230297462 | Gilton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | General Electric Company (Schenectady, New York) |
| INVENTOR(S) | Jeffrey S. Gilton (Cincinnati, Ohio); Matthew B. Pfenninger (Cincinnati, Ohio); Serge Rosine (Cincinnati, Ohio) |
| ABSTRACT | A method to be performed by a processor includes determining whether an application software has called an application programming interface, upon determination that the application software has called the application programming interface, determining whether one or more floating-point errors are recorded in a floating-point status register, and upon determination that one or more floating-point errors are recorded in the floating-point status register, performing a predefined action for each type of floating-point error recorded in the floating-point status register. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697465 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30101 (20130101) G06F 11/0721 (20130101) G06F 11/0793 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230297748 | Gore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake city, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ganesh Gore (Salt Lake City, Utah); Xifan Tang (Salt Lake City, Utah); Pierre-Emmanuel Gaillardon (Salt Lake City, Utah) |
| ABSTRACT | Technology is disclosed related to methods and devices for reducing the top-level placement and routing runtime of a field-programmable gate arrays (FPGA). The method can comprise: generating a global signal netlist comprising feedthrough connections through non-adjacent FPGA modules; selecting a predefined signal connection pattern for the global signal netlist; generating pre-routed feedthrough connections based on the predefined signal connection pattern and the global signal netlist; and generating a pre-routed global signal netlist from the pre-routed feedthrough connections. The FPGA can comprise an FPGA module configured to send a pre-routed global signal to a non-adjacent FPGA module through a pre-routed feedthrough connection identified using a predefined signal connection pattern. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695093 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/347 (20200101) Original (OR) Class G06F 2119/12 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230297838 | Chakrabartty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shantanu Chakrabartty (St. Louis, Missouri); Darshit Mehta (St. Louis, Missouri) |
| ABSTRACT | An analog memory device includes a first node and a second node. The first node includes a first floating gate, a second floating gate, and a capacitor. The first node first floating gate is connected to the first node second floating gate via the capacitor. The second node includes a first floating gate, a second floating gate, and a capacitor. The second node first floating gate is connected to the second node second floating gate via the capacitor. The second node is connected to the first node, and an analog state of the first node and an analog state of the second node continuously and synchronously decay with respect to time. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 18/042230 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Original (OR) Class G06N 3/0464 (20230101) Static Stores G11C 27/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298159 | Waite et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam R. Waite (Centerville, Ohio); Adam G. Kimura (Westerville, Ohio); James E. Schaffranek (Westerville, Ohio) |
| ABSTRACT | An integrated circuit (IC) layout extraction method includes executing: an image receiving pipeline that, for each tile n of N tiles of an IC, receives a tile image n of the tile n of the IC acquired using a microscope; a layout portion extraction pipeline that extracts a layout portion n from each received tile image n; and a layout portion comparison pipeline that compares each layout portion n with a corresponding portion of the reference IC layout. The image receiving pipeline, the layout portion extraction pipeline, and the layout portion comparison pipeline are parallel pipelines that are executed by the electronic processor concurrently in time. The extracted layout portions for the N tiles of the IC are combined to form the extracted layout for the IC. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/121069 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 1/20 (20130101) G06T 7/001 (20130101) Original (OR) Class G06T 2200/24 (20130101) G06T 2207/10056 (20130101) G06T 2207/20092 (20130101) G06T 2207/20212 (20130101) G06T 2207/30148 (20130101) Pictorial Communication, e.g Television H04N 23/695 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298243 | Nagano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NVIDIA Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Koki Nagano (Playa Vista, California); Jaewoo Seo (Kirkland, Washington) |
| ABSTRACT | A system and method for generating a digital avatar from a two-dimensional input image in accordance with a machine learning models is provided. The machine learning models are generative adversarial networks trained to process a latent code into three-dimensional data and color data. A generative adversarial network (GAN) inversion optimization algorithm is run on the first machine learning model to map the input image to a latent code for the first machine learning model. The latent code is used to generate unstructured 3D data and color information. A GAN inversion optimization algorithm is then run on the second machine learning model to determine a latent code for the second machine learning model, based at least on the output of the first machine learning model. The latent code for the second machine learning model is then used to generate the data for the digital avatar. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/185217 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 13/40 (20130101) Original (OR) Class G06T 13/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299020 | KIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinsang KIM (Ann Arbor, Michigan); Parag DEOTARE (Ann Arbor, Michigan); Da Seul YANG (Ann Arbor, Michigan); Che-Hsuan CHENG (Ann Arbor, Michigan) |
| ABSTRACT | An anti-tamper module includes a substrate and a photoisomerization (PI) layer formed on the substrate. The PI layer comprises molecules configured to transition from a first state to a second state in response to exposure to a first type of light and transition from the second state to the first state in response to exposure to a second type of light, and transitioning a selected portion of the PI layer to the first state while surrounding portions of the PI layer remain in the second state causes physical deformation of the PI layer. An excitonic layer is arranged on the PI layer. An electrical characteristic of the excitonic layer is sensitive to strain caused by the physical deformation of the PI layer such that an excitonic property of the excitonic layer changes in a region corresponding to the selected portion of the PI layer. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200019 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/573 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299172 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Analog Devices, Inc. (Wilmington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingqi Jiang (Bedford, Massachusetts); James G. Fiorenza (Carlisle, Massachusetts) |
| ABSTRACT | Techniques are described for forming a sealed cavity within a semiconductor wafer, where a conductor wafer includes a structure, such as a T-gate electrode or passive component, formed over a substrate. The sealed-cavity structure may be embedded into the wafer without interfering with any subsequent processes. That is, once the cavity is closed, any subsequent backend processes may continue as usual. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697758 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/408 (20130101) H01L 29/513 (20130101) H01L 29/515 (20130101) Original (OR) Class H01L 29/2003 (20130101) H01L 29/7781 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299210 | Usenko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alex Usenko (Lake St. Louis, Missouri); Anthony Caruso (Overland Park, Kansas); Steven Bellinger (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alex Usenko (Lake St. Louis, Missouri); Anthony Caruso (Overland Park, Kansas); Steven Bellinger (Manhattan, Kansas) |
| ABSTRACT | A method of producing a four-layer silicon diode, including selecting a first silicon wafer, wherein said first silicon wafer is CZ-grown B-doped with <100> orientation, a resistivity of less than 0.01 Ohm-cm, and an oxygen content of greater than 10 ppma, and then selecting a second silicon wafer, wherein said second silicon wafer is CZ-grown P-doped with <100> orientation, a resistivity of less than 0.005 Ohm-cm, and an oxygen content of greater than 10 ppma, followed by cleaning the respective first and second silicon wafers. The wafers are then HF treated to yield respective first and second cleaned wafers, the first cleaned wafer is positioned into a first furnace and the second cleaned wafer is positioned into a second furnace, wherein the first and second furnaces are not unitary. Next is annealing the respective first and second cleaned wafers in a reducing atmosphere to yield respective first and second respective out-diffused gradient wafers, followed by bonding together respective first and second heat-treated wafers to yield a mated and/or bonded four-layer substrate having a first heavy doped n-type layer, a second gradient doped n-type layer, a third gradient doped p-type layer, and a fourth heavy doped p-type layer. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855735 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/861 (20130101) Original (OR) Class H01L 29/66121 (20130101) H01L 29/66136 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299225 | Ryu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Kevin Ryu (Arlington, Massachusetts); Joseph S. Ciampi (Westford, Massachusetts); Brian F. AULL (Cambridge, Massachusetts); Kevan Donlon (Arlington, Massachusetts); Renee D. Lambert (Framingham, Massachusetts) |
| ABSTRACT | Fabrication of avalanche photodiodes on a first wafer for operation in Geiger mode and integration with read-out integrated circuits (ROICs), fabricated on a second wafer, are described. Photodiode arrays are fabricated using a thin epitaxial layer grown on a semiconductor-on-insulator wafer. Chips are diced from the first wafer and bump bonded to chips diced from the second wafer. |
| FILED | Wednesday, January 18, 2023 |
| APPL NO | 18/155876 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1443 (20130101) H01L 27/1446 (20130101) H01L 27/1469 (20130101) H01L 27/14632 (20130101) H01L 27/14634 (20130101) H01L 27/14636 (20130101) H01L 27/14643 (20130101) H01L 27/14687 (20130101) H01L 27/14692 (20130101) H01L 27/14698 (20130101) H01L 31/028 (20130101) H01L 31/1075 (20130101) H01L 31/1864 (20130101) H01L 31/1868 (20130101) H01L 31/1876 (20130101) Original (OR) Class H01L 31/02005 (20130101) H01L 31/02027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299320 | Kirklin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Matthew C. Kirklin (Lake Orion, Michigan); Alan B. Martin (Washington, Michigan); Biju Edamana (West Bloomfield, Michigan) |
| ABSTRACT | A distribution method and system for a plurality of fuel cell systems (FCSs) configured to provide electrical energy. The distribution being configured for determining a demand of a load for the electrical energy and correspondingly implementing a powering operation. The powering operation executing a startup operation according to a startup order specified for one or more secondary FCSs of the FCSs. The powering operation including individually performing the startup operations for each of the secondary FCSs according to the startup order, and while each of the second FCSs are performing the startup operation, controlling another one or more of the FCSs to mask a power variance associated therewith. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699698 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/70 (20190201) B60L 58/31 (20190201) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0494 (20130101) H01M 8/04225 (20160201) H01M 8/04302 (20160201) Original (OR) Class H01M 2250/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299495 | Kong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | USA as represented by Sec. of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Soon-Cheol Kong (Centerville, Ohio); George R. Simpson (Saint Paris, Ohio) |
| ABSTRACT | A photonic nanojet antenna system includes a dielectric element having a circular cross section and formed of a single dielectric material, and at least one feed antenna. The circular cross section of the dielectric element has a diameter such that a photonic nanojet, that is a narrow high-intensity electromagnetic beam, propagates from the dielectric element and into the feed antenna when the dielectric element is illuminated with electromagnetic plane waves. The dielectric element can be, but is not limited to, a sphere, a truncated cylinder, or an ellipsoid. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/122055 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 15/08 (20130101) Original (OR) Class H01Q 19/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299610 | MANN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Colin J. MANN (Los Angeles, California); Don Walker (Whittier, California) |
| ABSTRACT | Embodiments of the present invention include modular solar power cells, arrays, and power management systems for use in satellite systems and constellations. In one embodiment, a solar cell module can include: a module substrate including a high-emissivity side and a mounting side; a power management circuit mounted to the mounting side of the module substrate; a battery arranged adjacent to the power management circuit; a solar cell substrate arranged adjacent the battery and including an embedded battery heater; and a solar cell mounted directly to the solar cell substrate and connected to the battery. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695763 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/10 (20130101) B64G 1/425 (20130101) B64G 1/428 (20130101) B64G 1/443 (20130101) B64G 2001/1092 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0475 (20141201) H01L 31/02008 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/425 (20130101) H01M 10/615 (20150401) H01M 2010/4271 (20130101) H01M 2220/20 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/35 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230300120 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Benny N. Cheng (Chino Hills, California); Aaron Fogel (Corona, California); Peter Schaedler (Anaheim, California) |
| ABSTRACT | Systems and methods for lattice-based cryptography in accordance with embodiments of the invention are described. A process for sending a secure encrypted message includes obtaining, by a first device, a public key of a public key/private key pair, encrypting, by the first device, unencrypted payload data using a symmetric encryption key in a symmetric encryption operation, encrypting, by the first device, the symmetric encryption key using the public key of the message recipient in an asymmetric encryption operation, sending, by the first device, the encrypted payload data and the encrypted symmetric encryption key to a second device, receiving, by the second device, the encrypted payload data and the encrypted symmetric key, decrypting, by the second device, the encrypted symmetric key using a private key to recover the symmetric key, and decrypting, by the second device, the encrypted payload data using the symmetric key to recover the unencrypted payload data. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/982816 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0631 (20130101) H04L 9/0869 (20130101) H04L 9/3073 (20130101) H04L 63/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230300172 | Halford |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Caliola Engineering, LLC (Colorado Springs, Colorado) |
| ASSIGNEE(S) | Caliola Engineering, LLC (Colorado Springs, Colorado) |
| INVENTOR(S) | Thomas R. Halford (Colorado Springs, Colorado) |
| ABSTRACT | A system and method for cryptographically securing data communications between a group of networked devices establishes and maintains an overlay network at the Application Layer, on top of a unicast routing service provided at the Internetworking Layer. The overlay network provides first, the routes that are used to deliver multicast datagrams and second, the cryptographic keys used to secure multicast datagrams. A common cryptographic key is established between all members of each group, and end-to-end encryption ensures that multicast datagrams can be accessed only by authorized group members. In other embodiments, keys are established between pairs of adjacent devices in the overlay network, and hop-by-hop encryption ensures that multicast datagrams can be accessed only by overlay network members. |
| FILED | Monday, April 24, 2023 |
| APPL NO | 18/305930 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0841 (20130101) H04L 63/065 (20130101) H04L 63/168 (20130101) Original (OR) Class H04L 63/0435 (20130101) H04L 63/0464 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230300489 | Pimpinella et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sivananthan Laboratories, Inc. (Bolingbrook, Illinois) |
| ASSIGNEE(S) | Sivananthan Laboratories, Inc. (Bolingbrook, Illinois) |
| INVENTOR(S) | RIchard Edward Pimpinella (Oswego, Illinois); Anthony Joseph Ciani (Palatine, Illinois); Christoph Grein (Wheaton, Illinois) |
| ABSTRACT | A photodetector device is provided that includes a ROIC having a top surface with a plurality of electrically conductive first electrodes within a pattern of surface areas on the top surface each surface area having a border, and an electrically conductive electrode grid having a portion on the border of each of the surface areas; and a photodetector film overlying the surface area. The electrode grid can be configured to surround each surface area to define the borders of the surface areas as pixels. The photodetector film can be a colloidal quantum dot film. The ROIC has circuit elements signal-connected to the plurality of first electrodes. Methods for forming the photodetector device include photolithography and deposition methods. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/079687 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14645 (20130101) H01L 27/14683 (20130101) H01L 31/035218 (20130101) Pictorial Communication, e.g Television H04N 25/75 (20230101) Original (OR) Class H04N 25/77 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230293428 | Chauhan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anuj Chauhan (Golden, Colorado) |
| ABSTRACT | Methods of loading vitamin E onto contact lenses for use as drug-delivering ophthalmic devices are provided, as are contact lenses made by such methods and methods of treatment employing such contact lenses. The disclosed methods and devices achieve high vitamin E loading rates and significantly extend the duration of release of both hydrophilic and hydrophobic drugs, while limiting swelling of the lenses and risk of damage to the lenses during manufacture. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 17/990321 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0051 (20130101) Original (OR) Class A61K 31/5377 (20130101) A61K 47/10 (20130101) A61K 47/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293441 | Kempa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Krzysztof Kempa (Chestnut Hill, Massachusetts); MICHAEL J NAUGHTON (Waltham, Massachusetts) |
| ASSIGNEE(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| INVENTOR(S) | Krzysztof Kempa (Chestnut Hill, Massachusetts); MICHAEL J NAUGHTON (Waltham, Massachusetts) |
| ABSTRACT | Disclosed is a method for the cellular uptake of sugar-coated melanin nanoparticles by metastatic cancer cells followed by illumination with nonionizing radiation (e.g., visible or IR light) causing cell death. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/122221 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/2031 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293488 | Dantas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri); University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gautam Dantas (St. Louis, Missouri); Patrick Gonzales (St. Louis, Missouri); Kevin Forsberg (St. Louis, Missouri); Mitchell Pesesky (St. Louis, Missouri); Mayland Chang (South Bend, Indiana); Shahriar Mobashery (South Bend, Indiana) |
| ABSTRACT | The present disclosure encompasses antibacterial compositions and methods of treating bacterial infections caused by resistant bacteria. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063454 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/43 (20130101) A61K 31/407 (20130101) Original (OR) Class A61K 31/424 (20130101) A61K 31/431 (20130101) A61K 31/496 (20130101) A61K 31/546 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293582 | Roy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krishnendu Roy (Atlanta, Georgia); Nate Dwarshuis (Atlanta, Georgia); Ranjna Madan-Lala (Atlanta, Georgia); Kyung-Ho Roh (Atlanta, Georgia); Hannah Kathryn Wilson (Atlanta, Georgia) |
| ABSTRACT | The present disclosure provides a system for mimicking the secondary lymphoid organs where suspension cells (e.g., T cells) are expanded; methods el expanding activating, and transfecting the suspension cells in the synthetic, microenvironment, and suspension cells produced by such systems and methods. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/108869 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/20 (20130101) Peptides C07K 16/2809 (20130101) C07K 16/2818 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/18 (20130101) C12M 27/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293614 | FLOYD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth FLOYD (Baton Rouge, Louisiana); Adam MELVIN (Baton Rouge, Louisiana) |
| ABSTRACT | This invention is directed to methods of treating disease characterized by aberrations in the ubiquitin proteasome system (UPS). |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 18/016189 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/045 (20130101) A61K 36/282 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293704 | Benoit et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danielle Benoit (Rochester, New York); Alayna E. Loiselle (Rochester, New York); Emmanuela Adjei-Sowah (Greece, New York) |
| ABSTRACT | The present invention generally relates to novel compositions and methods for promoting regeneration of injured tendon. In some aspects, the composition comprises a nanoparticle that targets specifically to injured tendon to deliver a therapeutic agent that promotes tendon regeneration. In certain aspects, the methods comprise administering to a subject in need thereof a nanoparticle that targets specifically to injured tendon to deliver a therapeutic agent that promotes tendon regeneration. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160535 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/60 (20170801) Original (OR) Class A61K 47/64 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293783 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| INVENTOR(S) | Ji Chen (Houston, Texas); Jianfeng Zheng (Houston, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to implantable medical devices that are operational for mitigating radiofrequency (RF)-induced heating. The implantable medical devices generally include a ferrite material that is associated with at least one component of the implantable medical device and operational to reduce the RF-induced heating of the implantable medical device. Additional embodiments of the present disclosure pertain to methods of mitigating radiofrequency (RF)-induced heating of an implantable medical device by applying a ferrite material to at least one component of the implantable medical device. Thereafter, the ferrite material reduces the RF-induced heating of the medical device. In some embodiments, the methods of the present disclosure also include a step of implanting the implantable medical device into a subject, such as a human being. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/118359 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/14 (20130101) A61L 31/088 (20130101) Original (OR) Class A61L 2400/00 (20130101) A61L 2420/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293816 | Gholami |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Autonomous Healthcare, Inc. (Hoboken, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Behnood Gholami (Menlo Park, California) |
| ABSTRACT | The present disclosure describes a closed-loop fluid resuscitation and/or cardiovascular drug administration system that uses continuous measurements and adaptive control architecture. The adaptive control architecture uses a function approximator to identify unknown dynamics and physiological parameters of a patient to compute appropriate infusion rates and to regulate the endpoint of resuscitation. |
| FILED | Tuesday, May 23, 2023 |
| APPL NO | 18/321847 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/3569 (20130101) A61M 2230/00 (20130101) A61M 2230/06 (20130101) A61M 2230/30 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294069 | Jones et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher W. Jones (Atlanta, Georgia); Enerelt Burentugs (Atlanta, Georgia); Akshay Korde (Atlanta, Georgia); Sankar Nair (Atlanta, Georgia); Iman Nezam (Atlanta, Georgia); Gabriel Nicholas Short (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein are impregnated nanostructured hierarchical zeolitic materials comprising: a plurality of zeolite nanotubes, wherein each zeolite nanotube comprises a zeolitic wall perforated by a plurality of pores, the zeolitic wall defining a single longitudinal lumen, and wherein at least a portion of the plurality of zeolite nanotubes are impregnated with an amine. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/120583 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/25 (20130101) B01D 2253/304 (20130101) B01D 2253/308 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/183 (20130101) Original (OR) Class B01J 20/2808 (20130101) B01J 20/3204 (20130101) B01J 20/3272 (20130101) B01J 20/28007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294071 | FAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maohong FAN (Ames, Iowa); Xia CHEN (Laramie, Wyoming) |
| ABSTRACT | Embodiments described herein generally relate to compositions for CO2 absorption, desorption, and/or capture and processes for making such compositions. Embodiments described herein also generally relate to processes for CO2 absorption, CO2 desorption, and/or CO2 capture. In an embodiment, a composition for absorbing or desorbing CO2 is provided. The composition includes an organic amine. the composition further includes a carbon organic framework, an ion thereof, or combinations thereof, the carbon organic framework comprising a plurality of carboxylic acids. In another embodiment, a process for capturing CO2 from a gas stream is also provided. The process includes introducing the gas stream with a composition described herein under absorption conditions, the gas stream comprising CO2. The process further includes forming a CO2-enriched composition. |
| FILED | Friday, March 17, 2023 |
| APPL NO | 18/122940 |
| CURRENT CPC | Separation B01D 53/8671 (20130101) B01D 2255/70 (20130101) B01D 2257/504 (20130101) B01D 2258/06 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/262 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294086 | Henry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles S. Henry (Fort Collins, Colorado); Brian J. Geiss (Fort Collins, Colorado); David S. Dandy (Fort Collins, Colorado); Cody Carrell (Sun Prairie, Wisconsin); Jeremy Link (Fort Collins, Colorado); Isabelle Samper (Fort Collins, Colorado); Ana Sanchez-Cano (Fort Collins, Colorado); Ilhoon Jang (Seoul, South Korea); Zachary Call (Fort Collins, Colorado) |
| ABSTRACT | An assay device includes a colorimetric testing assembly including a detection area, a fluid inlet, and a microfluidic network including a first path extending to the detection area and a second path extending to the detection area. When a fluid (e.g., a buffer fluid or a combined buffer and sample solution) is provided to the fluid inlet, a first portion of the fluid rehydrates a first dried reagent (e.g., a dried enzyme label) disposed along the first path to produce a first rehydrated reagent and a second portion of the fluid rehydrates a second dried reagent (e.g., a dried substrate) to produce a second rehydrated reagent. The first rehydrated reagent and the second rehydrated reagent are then sequentially delivered to the detection area by capillary-driven flow to perform the assay. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 18/016753 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) Original (OR) Class B01L 3/50273 (20130101) B01L 2200/16 (20130101) B01L 2300/069 (20130101) B01L 2300/088 (20130101) B01L 2400/0406 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54388 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295456 | DUFFIE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SOUTH DAKOTA BOARD OF REGENTS (Pierre, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | WHYTNEIGH DUFFIE (Rapid City, South Dakota); TRAVIS WALKER (Rapid City, South Dakota); TSVETANKA FILIPOVA (RAPID CITY, South Dakota); TIMOTHY BRENZA (Rapid City, South Dakota); KEVIN BARZ (Rapid City, South Dakota) |
| ABSTRACT | The present disclosure relates to photo-curable resins, and, more particularly, to 3D-printable, surface-eroding, acrylic anhydride-based resins, including both acrylated and methacrylated chemistries. In a preferred embodiment, the resins compositions are degradeable. The disclosure also provides methods of preparing the photo-curable resins and embodiments of degradeable objects comprised of the photo-curable resins. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/185152 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 22/04 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 4/00 (20130101) C09D 135/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295616 | Negrete et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oscar Negrete (Livermore, California); Jennifer A. Doudna (Berkeley, California); Steven C. Strutt (Berkeley, California) |
| ABSTRACT | The present invention relates to a CRISPR-Cas based system for targeting nucleic acid sequences. In part, the invention relates to synthetic guiding components for targeting single-stranded sequences, as well as design principles for constructing such components. Also described herein are methods of employing such components, e.g., to repress or activate a desired target within the subject. |
| FILED | Wednesday, March 29, 2023 |
| APPL NO | 18/127853 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295638 | BRANGWYNNE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Clifford BRANGWYNNE (Hopewell, New Jersey); José L. AVALOS (Princeton, New Jersey); Mackenzie Thomas WALLS (Cinnaminson, New Jersey) |
| ABSTRACT | Provided herein are programmable condensate protein systems and nucleic acid constructs encoding the same. The protein system enables modular targeting of proteins of interest. Protein-peptide interaction domains (PPIDs) are incorporated to functionalize engineered condensates with the attributes of the recruited protein, resulting in a modular system that allows for diverse facile and reprogrammable applications, including in enzyme clustering of metabolic pathways. Colocalizing specific metabolic enzymes in these condensates results in functionalized organelles with which can be used to manipulate the output of engineered metabolic pathways for the production of a pharmaceutical precursor. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/928028 |
| CURRENT CPC | Peptides C07K 14/395 (20130101) C07K 2319/60 (20130101) C07K 2319/735 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 9/1014 (20130101) C12N 9/1085 (20130101) C12N 15/62 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101) Enzymes C12Y 202/01001 (20130101) C12Y 202/01002 (20130101) C12Y 205/01054 (20130101) C12Y 402/01011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295688 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155623 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295695 | Hart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Marie Hart (Cambridge, Massachusetts); Xiao Wang (Cambridge, Massachusetts); Mark Bathe (Cambridge, Massachusetts); Gabriela S. Schlau-Cohen (Cambridge, Massachusetts); Jiajia Guo (Changchun, China PRC) |
| ABSTRACT | Disclosed are nucleic acid-chromophores and nucleic acid assembly containing the nucleic acid-chromophores. The nucleic acid-chromophore contains a nucleic acid strand and two or more adjacent chromophores. The two or more adjacent chromophores can be covalently incorporated in the backbone of the nucleic acid strand. One or more photophysical properties of the adjacent chromophores can be altered by a change in the nucleic acid assembly. In some forms, the nucleic acid assembly can contain a nucleic acid scaffold. In these forms, the change in the nucleic acid assembly can be a change in the length of a nucleic acid hybrid in the nucleic acid scaffold that is opposite the adjacent chromophores. Typically, the nucleic acid hybrid does not contain any chromophore. The nucleic acid-chromophores can serve as molecular fluorophores with emission properties that are highly sensitive to local geometry and the chemical environment. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051344 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6832 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295717 | Phillips et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Phillips (Salt Lake City, Utah); Jennifer M. Heemstra (Salt Lake City, Utah) |
| ABSTRACT | Branching phosphoramidite monomers and molecules having comb-like structures are disclosed and described. A branching phosphoramidite monomer having the structure is provided wherein R4 and R5 are independently —(O—CH2—CH2—)n where n is 1-5 or —O—(CH2—)n where n is 1-10, and R1, R2, and R3 are each one of dimethoxytrityl (DMT)-O—, levulinyl (Lev)-O—, and a phosphoramidite. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/963119 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6816 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296017 | CARDIFF |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin) |
| INVENTOR(S) | MICHAEL CARDIFF (MADISON, Wisconsin) |
| ABSTRACT | A system for monitoring and establishing physical properties of a subsurface formation at a testing site having a source well and one or more receiver wells may include a pump, a data collection system, and a controller. The controller may cause the pump to extract fluid from and inject fluid into the source well based on one or more measures indicative of an amount of liquid in the source well. The controller may receive measures related to pressures in the receiver wells and physical properties of the subsurface formation may be determined based on the measures related to pressures in the receiver well. In some cases, noise may be removed from the measures related to pressures in the receiver wells to facilitate determining the physical properties of the subsurface formation. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/121904 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/12 (20130101) E21B 49/008 (20130101) Original (OR) Class E21B 2200/20 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296514 | Fahrni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christoph J. Fahrni (Atlanta, Georgia); Adam M. McCallum (Atlanta, Georgia); Michael Thomas Morgan (Atlanta, Georgia) |
| ABSTRACT | The compounds relate to zinc-sensitive fluorescent probes, compositions and methods utilizing the same. Such compounds provide an emission-ratiometric fluorescence response upon binding of an analyte. In some embodiments, compounds can be used for two-photon excitation microscopy or conventional fluorescence microscopy. The compounds described herein can also contain one or more functional groups to improve the emission-ratiometric fluorescence response. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/120783 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0021 (20130101) Heterocyclic Compounds C07D 417/04 (20130101) C07D 417/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/77 (20130101) G01N 21/6428 (20130101) Original (OR) Class G01N 33/582 (20130101) G01N 2021/6439 (20130101) G01N 2021/7786 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296528 | JABBARZADEH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | EHSAN JABBARZADEH (COLUMBIA, South Carolina); SARA ESLAMBOLCHIMOGHADAM (COLUMBIA, South Carolina) |
| ABSTRACT | Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections. |
| FILED | Thursday, May 25, 2023 |
| APPL NO | 18/323552 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14539 (20130101) A61B 2562/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/80 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296563 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shujie Yang (Durham, North Carolina); Tony Jun Huang (Durham, North Carolina) |
| ABSTRACT | Technologies for harmonic acoustic manipulation of colloidal particles include a system having a piezoelectric substrate coupled to one or more segmented acoustic transducers and a fluid positioned above the substrate. The segmented transducers have multiple segments, each with a resonant frequency equal to a harmonic frequency. The system further includes a controller that generates a harmonic signal including multiple harmonic components and applies the signal to the segmented acoustic transducers to generate an acoustic potential field in the fluid and manipulate the colloidal particles. The system may translate or rotate the particles, and may form the particles into a colloidal crystal monolayer. The system may selectively pair or otherwise group and separate individual particles. The system may pair and separate multiple groups of particles. The system may measure adhesion between particles. The system may pattern particles over a surface. The colloidal particles may be cells. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/120679 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/022 (20130101) Original (OR) Class G01N 29/036 (20130101) G01N 29/2437 (20130101) G01N 2291/0423 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/02559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296597 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nian-Xiang Sun (Winchester, Massachusetts); Shadi Emam (Boston, Massachusetts); Mehdi Nasrollahpour (Boston, Massachusetts) |
| ABSTRACT | Devices and methods for the detection of an analyte, e.g, from exhaled breath or air are provided. A sensor includes a polymer layer molecularly imprinted for the analyte, a metal layer, and an electrocatalytic layer disposed between the polymer layer and the metal layer. The electrocatalytic layer is functionalized with at least one chemical compound that provides for noncovalent interaction with the analyte. The sensor further includes electrodes in operative arrangement with the polymer layer and configured to provide a signal indicative of a resistance. A change in resistance of the device can indicate the presence of the analyte in the sample. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 18/040920 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/125 (20130101) G01N 33/5438 (20130101) Original (OR) Class G01N 33/56983 (20130101) G01N 2333/08 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296684 | Stefanopoulou et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anna Stefanopoulou (Ann Arbor, Michigan); Valentin Sulzer (Ann Arbor, Michigan); Peyman Mohtat (Ann Arbor, Michigan); Sravan Pannala (Ann Arbor, Michigan); Jason Siegel (Ann Arbor, Michigan) |
| ABSTRACT | Disclosed is a method for manufacturing an electrochemical cell wherein the cell undergoes degradation that results in loss of active material and cation inventory during charging phase(s) of cell cycles. The method comprises: selecting at least one cell component from electrolytes, cathode active materials, and anode active materials; sequentially calculating a cell capacity at an end of each of a plurality of cell cycles based on total cyclable cations, accessible storage sites in each electrode, and the cell component(s) using a degradation model based on porous-electrode theory and having degradation pathway(s), wherein the cell cycles are initialized based on a rate of degradation over previous cycles and wherein a time at which to simulate the next cycle is chosen based on the rate of degradation over the previous cycles; and predicting end of life of the cell based on one of the calculated cell capacities being less than a percentage of nominal capacity. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/122361 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/367 (20190101) G01R 31/392 (20190101) G01R 31/396 (20190101) G01R 31/3865 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230297331 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Deliang Fan (Tempe, Arizona); Fan Zhang (Tempe, Arizona); Shaahin Angizi (Newark, New Jersey) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Deliang Fan (Tempe, Arizona); Fan Zhang (Tempe, Arizona); Shaahin Angizi (Newark, New Jersey) |
| ABSTRACT | A method of calculating a boundary value of a set of numerical values in a volatile memory comprises storing a set of numerical values in a volatile memory, initializing a comparison vector, initializing a matching vector, transpose-copying a first bit of each of the set of numerical values into a buffer, calculating a result vector, updating the matching vector, repeating the previous steps for each of the bits in the set of numerical values, and returning the matching vector, where the position of each 1 remaining in the matching vector corresponds to an index of the boundary value in the set of numerical values, wherein the computation and the memory storage take place on the same integrated circuit. A system for calculating a boundary value of a set of numerical values is also disclosed. |
| FILED | Tuesday, March 21, 2023 |
| APPL NO | 18/187189 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/02 (20130101) Original (OR) Class G06F 7/78 (20130101) Pulse Technique H03K 19/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230297750 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Zhengfeng Wu (Philadelphia, Pennsylvania); Ioannis Savidis (Wallingford, Pennsylvania) |
| ABSTRACT | A simulation-based optimization framework determines the sizing of components of an analog circuit to meet target design specifications while also satisfying the robustness specifications set by the designer. The robustness is guaranteed by setting a limit on the standard deviations of the variations in the performance parameters of a circuit across all process and temperature corners of interest Classifier chains are used that, in addition to modeling the relationship between inputs and outputs, learn the relationships among output labels. Additional design knowledge is inferred from the optimal ordering of the classifier chain. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/185042 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/367 (20200101) Original (OR) Class G06F 2119/02 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230297838 | Chakrabartty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shantanu Chakrabartty (St. Louis, Missouri); Darshit Mehta (St. Louis, Missouri) |
| ABSTRACT | An analog memory device includes a first node and a second node. The first node includes a first floating gate, a second floating gate, and a capacitor. The first node first floating gate is connected to the first node second floating gate via the capacitor. The second node includes a first floating gate, a second floating gate, and a capacitor. The second node first floating gate is connected to the second node second floating gate via the capacitor. The second node is connected to the first node, and an analog state of the first node and an analog state of the second node continuously and synchronously decay with respect to time. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 18/042230 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Original (OR) Class G06N 3/0464 (20230101) Static Stores G11C 27/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298060 | Seetharaman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Sivaranjani Seetharaman (College Station, None); Panganamala R. Kumar (College Station, Texas); Le Xie (College Station, None) |
| ABSTRACT | Methods, systems, and computer readable media for thermal load management of a collection of power consumers managed by an electric power aggregator. In some examples, a system includes a scheduling subsystem, implemented on one or more processors, configured for determining a plurality of cooling or heating control schedules for the collection of power consumers by forecasting one or more wholesale electricity price peaks. The system includes a control system implemented on one or more processors. The control system is configured for carrying out the cooling or heating control schedules at the individual consumer-level. The control system is configured for guaranteeing, for each power consumer of the collection of power consumers, a comfort constraint specified by a bilevel thermostat for the power consumer, wherein the comfort constraint comprises a lower level bound temperature and an upper bound temperature that the power consumer is willing to tolerate. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 18/019022 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0206 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/003 (20200101) H02J 3/14 (20130101) H02J 2310/64 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298790 | Markiewicz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Denis Markiewicz (Ipswich, Massachusetts); Mark D. Bird (Tallahassee, Florida); Iain R. Dixon (Tallahassee, Florida); William Scott Marshall (Tallahassee, Florida); Thomas A. Painter (Tallahassee, Florida); Peng Xu (Tallahassee, Florida) |
| ABSTRACT | A magnet includes a stack of a plurality of superconducting pancake wound coils having a stacking axis normal to a winding direction of the coils. The stack has axial ends and has a stack midplane relative to the stacking axis. A quench detector is provided for detecting a quench in the stack of superconducting pancake wound coils. A plurality of resistance quench heaters (RQH) are distributed symmetrically along the axis with respect to the stack midplane. Control circuitry is provided for controlling the operation of the RQH upon the detection of a quench by the quench detector. A method of quenching a magnet is also disclosed. |
| FILED | Thursday, March 16, 2023 |
| APPL NO | 18/122276 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/02 (20130101) Original (OR) Class H01F 6/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298858 | Foster et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Foster (Ann Arbor, Michigan); Mirko Gamba (Ann Arbor, Michigan) |
| ABSTRACT | A surface treatment device includes a body and a plasma source disposed within the body. The plasma source includes a first inlet through the body and an ionization wave generator adjacent the first inlet to receive feedstock gas via the first inlet. The ionization wave generator includes a dielectric tube that necks down to define an elongated throat. The surface treatment device also includes a second inlet through the body and an expansion nozzle disposed within the body downstream of the second inlet. The second inlet is disposed at the elongated throat to provide further feedstock gas. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 18/021309 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/32348 (20130101) Original (OR) Class H01J 37/32449 (20130101) H01J 37/32825 (20130101) H01J 37/32853 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299330 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Jin-Myoung Lim (Coppell, Texas) |
| ABSTRACT | A composite, an anode electrode for an electrochemical device including said composite, and a fabricating method of said composite. Said composite includes graphene and nanoparticles of an active material, wherein said nanoparticles are conformally coated and networked by said graphene. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 18/021429 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/139 (20130101) H01M 4/0416 (20130101) H01M 4/505 (20130101) H01M 4/625 (20130101) H01M 4/1393 (20130101) H01M 10/0525 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299451 | Aquino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hadrian Aquino (South Bend, Indiana); Alexei Orlov (South Bend, Indiana); Gary H. Bernstein (South Bend, Indiana); Jonathan Chisum (South Bend, Indiana); David Connelly (South Bend, Indiana); Wolfgang Porod (South Bend, Indiana) |
| ABSTRACT | A device that produces spin waves includes a base substrate, a transducer that includes a first plane defined by a first magnetic film and a second plane defined by a plurality of metal strips, and a second magnetic film having a spin-wave phase velocity lower than the first magnetic film. The second magnetic film is adjacent to the first magnetic film, and the first plane and the second plane are parallel. The plurality of metal strips are configured to receive a first signal, such that the first signal excites a first spin wave in the first magnetic film. The second magnetic film is configured to produce a second spin wave having a wavelength shorter than the first spin wave. |
| FILED | Friday, March 17, 2023 |
| APPL NO | 18/185756 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/32 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299775 | Savidis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Ioannis Savidis (Wallingford, Pennsylvania); Ziyi Chen (Philadelphia, Pennsylvania) |
| ABSTRACT | In this paper, a novel field-programmable analog array (FPAA) is proposed to secure the intellectual property (IP) of analog and mixed-signal circuits. A obfuscation technique is developed to efficiently mask the topology of both differential mode and single-ended mode analog circuits. |
| FILED | Monday, April 24, 2023 |
| APPL NO | 18/305718 |
| CURRENT CPC | Pulse Technique H03K 19/17728 (20130101) H03K 19/17768 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230301202 | Wu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Judy Z. Wu (Lawrence, Kansas) |
| ABSTRACT | Superconducting nanocomposites are provided. One such nanocomposite comprises a high temperature superconductor (HTS); a plurality of artificial pinning centers (APCs) in the form of one-dimensional (1D) nanorods distributed throughout the HTS and oriented parallel to a c-axis of the HTS, each APC composed of a non-superconducting material and surrounded by the HTS, thereby forming an APC-HTS interface; and one or more repair regions composed of a repair material comprising a cation A, wherein a portion of the cation A of the repair material has diffused out of the one or more repair regions and into the HTS. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 18/040912 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Electric solid-state devices not otherwise provided for H10N 60/0828 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230292687 | Mockler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Donald Danforth Plant Science Center (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd C. Mockler (St. Louis, Missouri); Nadia Shakoor (St. Louis, Missouri); Scott Lee (St. Louis, Missouri); Erica Agnew (St. Louis, Missouri); Greg Ziegler (St. Louis, Missouri); Jennifer Arp (St. Louis, Missouri) |
| ABSTRACT | Provided herein are a sorghum genomic region, alleles, and genotypes that are shown to be associated with a cold-stress tolerance phenotype. Also provided are genetically edited plastocyanin genes that result in a cold-stress tolerance phenotype. Also provided are cold-tolerant plants comprising an introgressed genomic region associated with cold-stress tolerance. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/917746 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/1225 (20210101) Original (OR) Class A01H 5/10 (20130101) A01H 6/4666 (20180501) Peptides C07K 14/415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294033 | Thallapally et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Praveen K. Thallapally (Richland, Washington); John D. Vienna (Richland, Washington) |
| ABSTRACT | Methods and materials for the selective capture and storage of preselected materials from gas streams using metal organic framework (MOF) materials are described. In various embodiments preselected target material gases could include noble gasses such as Kr, Xe, Rn, Ar other gasses such as I2 or other particular isotopes either naturally occurring or man-made, or another preselected gas capture material such as a target material for legal, regulatory or treaty compliance, or a preselected material from a particular process such as a cleaning or etching agent from semiconducting or microelectronic manufacture, or a portion of an anesthetic gas such as nitrous oxide, isoflurane, sevoflurane or a fluorinated ethers. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697456 |
| CURRENT CPC | Separation B01D 15/08 (20130101) B01D 53/04 (20130101) Original (OR) Class B01D 59/26 (20130101) B01D 2253/204 (20130101) B01D 2253/308 (20130101) B01D 2257/11 (20130101) B01D 2257/202 (20130101) B01D 2259/402 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) B01J 20/2808 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294047 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Engi-Mat Co. (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Wilson (Lexington, Kentucky); Haibing Wang (Phoenix, Arizona); Claudia Goggin (Lexington, Kentucky); Brian Mackey (Lexington, Kentucky) |
| ABSTRACT | Composite structures composed of inorganic membranes or polymer membranes supported on a multilayered woven wire mesh substrate are provided. Also provided are methods of making the composite structures and methods of using the composite structures as separation membranes. The mesh substrates are composed of a stack of two or more layers of woven wire mesh, wherein the different mesh layers in the stack have different mesh sizes. The multilayered mesh structure can support a defect-free, or substantially defect-free, membrane and has sufficient mechanical strength to allow the supported membranes to be used for chemical separations. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/183255 |
| CURRENT CPC | Separation B01D 61/362 (20130101) B01D 61/363 (20220801) B01D 67/0039 (20130101) B01D 69/04 (20130101) B01D 69/108 (20220801) Original (OR) Class B01D 71/0281 (20220801) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/448 (20130101) C02F 2101/34 (20130101) Acyclic or Carbocyclic Compounds C07C 29/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294072 | BRAUNECKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wade Adam BRAUNECKER (Lafayette, Colorado); Noemi LEICK (Boulder, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes tetrakis(4-hydroxyphenyl)ethylene (THPE), an amino polymer, and a substrate that includes a metal oxide, where the substrate has a pore volume, and the THPE and the amino polymer are positioned within the pore volume. |
| FILED | Friday, March 17, 2023 |
| APPL NO | 18/185747 |
| CURRENT CPC | Separation B01D 53/0407 (20130101) B01D 53/0454 (20130101) B01D 2253/202 (20130101) B01D 2253/308 (20130101) B01D 2253/311 (20130101) B01D 2257/504 (20130101) B01D 2259/126 (20130101) B01D 2259/802 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/262 (20130101) Original (OR) Class B01J 20/2805 (20130101) B01J 20/3204 (20130101) B01J 20/28069 (20130101) B01J 20/28078 (20130101) B01J 20/28097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230294993 | KANATZIDIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercouri G. KANATZIDIS (Wilmette, Illinois); Daniel G. CHICA (Evanston, Illinois); Yihui HE (Evanston, Illinois); Duck Young CHUNG (Bolingbrook, Illinois) |
| ABSTRACT | Inorganic compounds having the formula LiMP2Q6, where M is Ga, In, Bi, Sb, As, Al, or a combination thereof, and Q is S and/or Se, are provided. Methods and devices for detecting incident neutrons and alpha-particles using the compounds are also provided. For thermal neutron detection applications, the compounds can be enriched with lithium-6 isotope (6Li) to enhance their neutron detecting capabilities. |
| FILED | Tuesday, May 02, 2023 |
| APPL NO | 18/142220 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 25/14 (20130101) Original (OR) Class Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/00 (20130101) C30B 29/46 (20130101) Measurement of Nuclear or X-radiation G01T 1/24 (20130101) G01T 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295393 | Naskar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit K. Naskar (Knoxville, Tennessee); Ngoc A. Nguyen (Oak Ridge, Tennessee) |
| ABSTRACT | A porous composition comprising a porous organic polymer (POP) fiber having a diameter of at least 100 nm and a length of at least 1 mm and pores having a size within a range of 10 nm to 5 microns distributed over the surface and volume of the POP fiber, wherein the organic polymer is insoluble in water and may be selected from, e.g., polyolefins, polyesters, polyamides, and polyacrylonitrile. Also described herein is a method for producing a POP fiber comprising: (i) forming a precursor fiber from a blend of an organic polymer and lignin, wherein the lignin is present in the form of domains within the precursor fiber; and (ii) washing the precursor fiber with a solvent that dissolves the lignin to result in the POP fiber. Also described herein is a method for removing oil from an oil-water mixture comprising contacting the oil-water mixture with the POP fibers. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/121338 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/26 (20130101) Original (OR) Class C08J 9/35 (20130101) C08J 2201/042 (20130101) C08J 2205/044 (20130101) C08J 2323/12 (20130101) C08J 2333/20 (20130101) C08J 2367/03 (20130101) C08J 2377/02 (20130101) Compositions of Macromolecular Compounds C08L 23/12 (20130101) C08L 33/20 (20130101) C08L 67/03 (20130101) C08L 77/02 (20130101) C08L 97/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295616 | Negrete et al. |
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| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oscar Negrete (Livermore, California); Jennifer A. Doudna (Berkeley, California); Steven C. Strutt (Berkeley, California) |
| ABSTRACT | The present invention relates to a CRISPR-Cas based system for targeting nucleic acid sequences. In part, the invention relates to synthetic guiding components for targeting single-stranded sequences, as well as design principles for constructing such components. Also described herein are methods of employing such components, e.g., to repress or activate a desired target within the subject. |
| FILED | Wednesday, March 29, 2023 |
| APPL NO | 18/127853 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295695 | Hart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Marie Hart (Cambridge, Massachusetts); Xiao Wang (Cambridge, Massachusetts); Mark Bathe (Cambridge, Massachusetts); Gabriela S. Schlau-Cohen (Cambridge, Massachusetts); Jiajia Guo (Changchun, China PRC) |
| ABSTRACT | Disclosed are nucleic acid-chromophores and nucleic acid assembly containing the nucleic acid-chromophores. The nucleic acid-chromophore contains a nucleic acid strand and two or more adjacent chromophores. The two or more adjacent chromophores can be covalently incorporated in the backbone of the nucleic acid strand. One or more photophysical properties of the adjacent chromophores can be altered by a change in the nucleic acid assembly. In some forms, the nucleic acid assembly can contain a nucleic acid scaffold. In these forms, the change in the nucleic acid assembly can be a change in the length of a nucleic acid hybrid in the nucleic acid scaffold that is opposite the adjacent chromophores. Typically, the nucleic acid hybrid does not contain any chromophore. The nucleic acid-chromophores can serve as molecular fluorophores with emission properties that are highly sensitive to local geometry and the chemical environment. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051344 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6832 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295704 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Liangcai Gu (Boston, Massachusetts) |
| ABSTRACT | Methods for attaching barcodes to polypeptides are provided. Methods for detecting molecular interactions at the single molecule level are provided. Embodiments of the invention are directed to a ONA barcoded protein array technology for parallel protein interaction profiling on a single molecule basis. DNA barcodes are attached to proteins collectively via ribosome display or individually via enzymatic conjugation. Novel methods are described herein that measure protein interactions based on the statistical analysis of co-localized polonies arising from barcoding DNAs of interacting proteins. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944306 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6809 (20130101) C12Q 1/6853 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295918 | Sharma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaswinder K. Sharma (Oak Ridge, Tennessee); Georgios Polyzos (Oak Ridge, Tennessee) |
| ABSTRACT | A method of encapsulating a phase change material includes providing a co-axial ejector including first and second coaxially-disposed outlets, with the first outlet being inside of and surrounded by the second outlet. A core composition including a phase change material is fed to the first outlet. A coating composition is fed to the second outlet. The core composition and the coating composition are simultaneously ejected from the ejector onto a collector. The core composition is surrounded by the coating composition and together ejected onto the collector to form an encapsulated core-shell phase change material fiber. No voltage is applied to the ejector during ejection, and the method does not include electrospinning. The core-shell fiber has a phase change material core surrounded by a polymer shell and a diameter in the range of 10-10,000 μm. The core constitutes from 30% to 97% by volume of the core-shell fiber. |
| FILED | Friday, March 10, 2023 |
| APPL NO | 18/119890 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/14 (20130101) General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 1/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296264 | Alavandi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UTILIZATION TECHNOLOGY DEVELOPMENT, NFP (Des Plaines, Illinois) |
| ASSIGNEE(S) | UTILIZATION TECHNOLOGY DEVELOPMENT, NFP (Des Plaines, Illinois) |
| INVENTOR(S) | Sandeep Alavandi (Schaumburg, Illinois); Hamid Abbasi (Naperville, Illinois); David Cygan (Villa Park, Illinois); John Wagner (La Grange, Illinois) |
| ABSTRACT | An apparatus and method for producing heat and electricity independent of an electrical grid. The apparatus includes a burner adapted to produce at least one of radiant heat, flame and hot combustion gases. A thermal-to-electric conversion device is integrated with the burner and proximate to the burner, for producing electricity. The conversion device has a first side disposed toward the at least one of radiant heat, flame and hot combustion gases and a second side disposed toward and in heat transfer contact with a liquid supply line. The apparatus is useful in water heaters. The liquid supply line provides both water to be heated and a cooling medium for the thermal-to-electric conversion device. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/121154 |
| CURRENT CPC | Domestic- or Space-heating Systems, e.g Central Heating Systems; Domestic Hot-water Supply Systems; Elements or Components Therefor F24D 18/00 (20220101) Original (OR) Class F24D 2101/60 (20220101) F24D 2103/13 (20220101) F24D 2103/17 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296445 | Odell |
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| FUNDED BY |
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| APPLICANT(S) | Randall N. Odell (Schenectady, New York) |
| ASSIGNEE(S) | United States Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Randall N. Odell (Schenectady, New York) |
| ABSTRACT | Disclosed is a stacked thick film device including a substrate, a first active element, a second active element, and an insulating dielectric layer separating the first active element and the second active element. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/948405 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 1/026 (20130101) G01K 1/143 (20130101) Original (OR) Class G01K 7/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296956 | Datta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ipshita Datta (New York, New York); Michal Lipson (New York, New York); Sang Hoon Chae (New York, New York); James Hone (New York, New York) |
| ABSTRACT | Methods and systems are described for modulating optical signals. An example method may comprise supplying, via a waveguide, an optical signal to a resonator optically coupled to the waveguide. The method may comprise modulating a phase of the optical signal based on at least one layer comprising an electro-optic material having an electro-refractive property and an electro-absorptive property. The modulating of the phase may be based on using the at least one layer to tune a coupling of the waveguide and the resonator between being under-coupled and being over-coupled. The method may comprise outputting, via the waveguide, the modulated optical signal. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063352 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0018 (20130101) G02F 1/035 (20130101) G02F 1/2252 (20130101) Original (OR) Class G02F 2203/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230297485 | VAIDYA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NVIDIA CORPORATION (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pranav VAIDYA (San Jose, California); Alan MENEZES (San Jose, California); Siddharth SHARMA (San Jose, California); Jin OUYANG (Cupertino, California); Gregory Paul SMITH (Leander, Texas); Timothy J. MCDONALD (Austin, Texas); Shounak KAMALAPURKAR (Santa Clara, California); Abhijat RANADE (Austin, Texas); Thomas Melvin OGLETREE (Lakeway, Texas) |
| ABSTRACT | Various embodiments include a system for generating performance monitoring data in a computing system. The system includes a unit level counter with a set of counters, where each counter increments during each clock cycle in which a corresponding electronic signal is at a first state, such as a high or low logic level state. Periodically, the unit level counter transmits the counter values to a corresponding counter collection unit. The counter collection unit includes a set of counters that aggregates the values of the counters in multiple unit level counters. Based on certain trigger conditions, the counter collection unit transmits records to a reduction channel. The reduction channel includes a set of counters that aggregates the values of the counters in multiple counter collection units. Each virtual machine executing on the system can access a different corresponding reduction channel, providing secure performance metric data for each virtual machine. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698668 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/10 (20130101) G06F 11/3409 (20130101) Original (OR) Class G06F 21/602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230297672 | Watson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jean-Paul Watson (Livermore, California); Alyson Lindsey Fox (San Leandro, California); Sarah Camille Mousley Mackay (Livermore, California); Wayne Bradford Mitchell (Hayward, California); Matthew Landen (Atlanta, Georgia); Key-Whan Chung (Urbana, Illinois); Elizabeth Diane Reed (Urbana, Illinois) |
| ABSTRACT | A method is disclosed which comprises accessing a detector model that is trained in parallel with an operator model and an attacker model using a reinforcement learning technique based on iteratively simulating scenarios of operation of an environment to generate training data and learning weights of the models based on the simulated training data. The simulating of a scenario is based on the last learned weights of the models. The method further comprises, during operation of the environment, applying the detector model to an operator action, a prior observation of state of the environment from prior to taking the operator action, and a current observation of the environment from after taking the operator action, to detect whether an attack on the environment has occurred. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089373 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/554 (20130101) Original (OR) Class G06F 2221/034 (20130101) Computer Systems Based on Specific Computational Models G06N 3/092 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230297843 | WACHTOR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Triad National Security, LLC (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Joseph WACHTOR (Santa Fe, New Mexico); Eric Brian FLYNN (Santa Fe, New Mexico); Erica Marie JACOBSON (Los Alamos, New Mexico); Ian Thomas CUMMINGS (Los Alamos, New Mexico); Joshua David ECKELS (Ann Arbor, Michigan); Isabel Faith FERNANDEZ (Atlanta, Georgia); Kelly HO (Seattle, Washington) |
| ABSTRACT | A method and system employing deep learning techniques improves processing speed and spatial resolution of acoustic wavenumber spectroscopy (ASSESS) techniques by performing semantic segmentation on simulated ultrasonic wavefield images of a steady-state, select-tone excitation of a structural or mechanical component. One or more embodiments may employ a convolutional neural network (CNN), pre-trained on openly-available datasets, and trained by transfer learning on an augmented wavefield dataset, to localize and characterize defects or damage from inspection measurements of components. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/121760 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/096 (20230101) Original (OR) Class G06N 3/0464 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298209 | Habib |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ayman F. Habib (West Lafayette, Indiana) |
| ABSTRACT | Boresight and lever arm calibration of cameras and scanners on UAVs or mobile platforms is performed by optimizing the flight/travel path of the UAV/platform relative to control points or tie points. The flight/travel paths account for the potential bias of boresight angles, lever arm and times delays to produce an accurate estimation of the orientation of these cameras/scanners relative to the GNSS/INS coordinate system o the UAV/platform. |
| FILED | Monday, March 20, 2023 |
| APPL NO | 18/186376 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 2101/30 (20230101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/89 (20130101) Image Data Processing or Generation, in General G06T 7/74 (20170101) G06T 7/80 (20170101) Original (OR) Class G06T 2207/10028 (20130101) Traffic Control Systems G08G 5/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298771 | Forest et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cary Brett Forest (Madison, Wisconsin); Jeremiah Kirch (Waunakee, Wisconsin); Douglass A Endrizzi (Monona, Wisconsin); Jan Egedal (Cambridge, Massachusetts); Jay Anderson (Madison, Wisconsin) |
| ABSTRACT | A direct converter for an axisymmetric mirror confinement system provides a set of radially symmetric vanes charged to capture ions escaping along the axis of the confinement system and to convert their energy to electrical power. An electron trap positioned before the charged vanes uses a magnetic field to divert and collect electrons, separating them from the ions, and may support a radial electric field providing plasma control. The charged vanes may be constructed of or have a coating of a getter material absorbing neutrals derived from those ions after capture. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/654920 |
| CURRENT CPC | Fusion Reactors G21B 1/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298777 | Zillmer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. Zillmer (Idaho Falls, Idaho); Michael A. Reichenberger (Idaho Falls, Idaho) |
| ABSTRACT | A power generation device may include a radiation source, an emitter, and a collector. The emitter may be formed adjacent to the radiation source. The emitter may include a high-density material. The collector may be adjacent to the radiation source and include a low-density material. The emitter is between the radiation source and the collector. An insulator may be positioned between the emitter and the collector. An emitter of a nuclear battery and a method of forming an emitter of a nuclear battery are also disclosed. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/183737 |
| CURRENT CPC | Obtaining Energy From Radioactive Sources; Applications of Radiation From Radioactive Sources, Not Otherwise Provided For; Utilising Cosmic Radiation G21H 1/106 (20130101) Original (OR) Class Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230298812 | Hatch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Douglas Hatch (Cleveland, Missouri); Bob Dearth (Kansas City, Missouri); Ida Sanchez (Leawood, Kansas); Francisco Garcia-Moreno (Spring, Texas) |
| ABSTRACT | Systems and methods for forming a magnetically-enabled part via additive manufacturing. The method includes depositing a layer of additive manufacturing material on a build plate, melting or sintering the layer of additive manufacturing material, depositing additional layers of additive manufacturing material on previous layers of additive manufacturing material, the additive manufacturing material of at least some of the additional layers being magnetically permeable, and melting or sintering the additional layers of additive manufacturing material such that the magnetically-enabled part has a transition region including at least some of the magnetically permeable additive manufacturing material. |
| FILED | Thursday, May 11, 2023 |
| APPL NO | 18/196020 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/00 (20210101) B22F 10/25 (20210101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/342 (20151001) B23K 2103/04 (20180801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 41/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299216 | Tao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Meng Tao (Fountain Hills, Arizona); Wen-Cheng Sun (Tempe, Arizona); Xiaofei Han (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meng Tao (Fountain Hills, Arizona); Wen-Cheng Sun (Tempe, Arizona); Xiaofei Han (Tempe, Arizona) |
| ABSTRACT | Electroplating of aluminum may be utilized to form electrodes for solar cells. In contrast to expensive silver electrodes, aluminum allows for reduced cell cost and addresses the problem of material scarcity. In contrast to copper electrodes which typically require barrier layers, aluminum allows for simplified cell structures and fabrication steps. In the solar cells, point contacts may be utilized in the backside electrodes for increased efficiency. Solar cells formed in accordance with the present disclosure enable large-scale and cost-effective deployment of solar photovoltaic systems. |
| FILED | Thursday, May 11, 2023 |
| APPL NO | 18/315630 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/44 (20130101) C25D 3/665 (20130101) C25D 5/50 (20130101) C25D 7/12 (20130101) C25D 7/126 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1864 (20130101) H01L 31/022425 (20130101) H01L 31/022458 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/50 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299330 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Jin-Myoung Lim (Coppell, Texas) |
| ABSTRACT | A composite, an anode electrode for an electrochemical device including said composite, and a fabricating method of said composite. Said composite includes graphene and nanoparticles of an active material, wherein said nanoparticles are conformally coated and networked by said graphene. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 18/021429 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/139 (20130101) H01M 4/0416 (20130101) H01M 4/505 (20130101) H01M 4/625 (20130101) H01M 4/1393 (20130101) H01M 10/0525 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299336 | Visco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | PolyPlus Battery Company (Berkeley, California) |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Vitaliy Nimon (San Francisco, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California) |
| ABSTRACT | A sulfide glass solid electrolyte sheet can be protected from reaction with moisture by a thin metal layer coating converted to a thin electrochemically functional and protective compound layer. The converted protective compound layer is electrochemically functional in that it allows for through transport of lithium ions. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/175374 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 50/403 (20210101) H01M 50/437 (20210101) H01M 50/451 (20210101) H01M 50/457 (20210101) H01M 2300/0068 (20130101) H01M 2300/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299385 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hsin Wang (Oak Ridge, Tennessee); Beth L. Armstrong (Oak Ridge, Tennessee); Mary K. Burdette-Trofimov (Oak Ridge, Tennessee); Chanaka Ihala Gamaralalage (Oak Ridge, Tennessee) |
| ABSTRACT | A temperature sensitive coating for application on a surface is provided. The temperature sensitive coating comprises an indicator component. The indicator component includes a carrier and a releasable compound that is held by the carrier. The releasable compound is in a gas state at a critical release temperature, and is released from the carrier at a temperature that is at or above the critical release temperature. A method of coating a surface of an energy storage system, and a method of detecting the approach of thermal runaway of an energy storage system, are also provided. The method includes coating a surface with the temperature sensitive coating, providing a gas sensor in the vicinity of the surface that is capable of detecting the presence of the releasable compound, monitoring the output of the sensor, and signaling an alarm when the sensor output indicates the presence of the releasable compound. |
| FILED | Thursday, March 09, 2023 |
| APPL NO | 18/119373 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/48 (20130101) H01M 10/63 (20150401) H01M 10/6551 (20150401) Original (OR) Class H01M 10/6595 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299659 | BANERJEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arijit BANERJEE (Urbana, Illinois); Kiruba Sivasubramaniam HARAN (Champaign, Illinois); Phuc HUYNH (Urbana, Illinois); Anjana Jayasanka SAMARAKOON (Urbana, Illinois) |
| ABSTRACT | An integrated multi-port generator-rectifier device includes multiple passive output ports provided from a plurality of passive-rectifier windings on a common, single magnetic structure. The passive-rectifier windings interact with a plurality of magnetic poles. Coils in the passive rectifier windings are serially connected. Each of the passive rectifier windings has a pitch as that is a fraction of magnet pole pitch and a pattern to magnetically decouple back emf phases of the separate rectifiers. The device further includes an active port provided by an active rectifier. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/182610 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/01 (20130101) H02J 2300/28 (20200101) Dynamo-electric Machines H02K 21/16 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/143 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230300996 | Eickbush et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Eickbush (Grandview, Missouri); Neiko P. Levenhagen (Lee's Summit, Missouri); Christopher Scott Marchman (Overland Park, Kansas); Steven Patterson (Kansas City, Missouri); Nicholas J. Furman (Overland Park, Kansas) |
| ABSTRACT | Systems and methods for providing an electronics module including a raceway for mounting submodules and establishing electrical communication with said submodules. The raceway comprises a base structure and a conductive trace formed by a conductive plating process. Connection pads on the raceway are configured to receive connection nodes of the submodules for providing a continuous electrical connection between the raceway and the submodules for electrical communication and power transmission. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698412 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/111 (20130101) H05K 1/181 (20130101) H05K 3/181 (20130101) H05K 5/0065 (20130101) Original (OR) Class H05K 2201/10106 (20130101) H05K 2201/10151 (20130101) H05K 2203/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230292686 | Morris et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey P. Morris (Manhattan, Kansas); Terry Felderhoff (Manhattan, Kansas); Sandeep Marla (Manhattan, Kansas) |
| ABSTRACT | Disclosed herein are markers which are associated with chilling tolerance and provide for breeding methods to identify such plants to integrate this trait into cereal plants and further to identify analogous markers in other cereal plants. Importantly, these markers are not linked with deleterious traits such as tall plant height or tannin content, providing for the creation of plant varieties and elite plant varieties with chilling tolerance, dwarf plant height and lack of tannins. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/906657 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/1225 (20210101) Original (OR) Class A01H 6/4666 (20180501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6895 (20130101) C12Q 2600/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230292766 | Trail et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frances Trail (Mason, Michigan); Zachary A. Noel (Auburn, Alabama); Ludmilla V. Roze (Okemos, Michigan) |
| ABSTRACT | Described herein are methods and compositions that reduce the spread and/or mycotoxin production of Fusarium graminearum. The methods and compositions involve use of one or more of the following endophytes: Alternaria destruens, Fusarium commune, Fusarium oxysporum, or a combination thereof. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/184496 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/30 (20200101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 3/00 (20210801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293607 | LORCA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Graciela Liliana LORCA (Gainesville, Florida); Claudio F. GONZALEZ (Gainesville, Florida) |
| ABSTRACT | A composition is provided herein directed to a mixture of one or more Lactobacillus sp. and a phenolic compound. In a specific embodiment, disclosed is a Lactobacillus/phenol mixture that has been lyophilized to form a Lactobacillus/phenol lyophilized mixture. The Lactobacillus/phenol mixture of Lactobacillus/phenol lyophilized mixture may be packaged in a capsule, emulsion, or tablet such that the Lactobacillus are protected in a gastrointestinal tract for transport to an intestine of a subject. In another embodiment, a method for treating indigestion, abdominal pain or cephalic syndrome in a subject including orally administering to the subject a composition comprising an effective amount of Lactobacillus/phenol mixture or lyophilized mixture. In still a further embodiment, of improving immune function in a subject, comprising administering to the subject, the composition comprising an effective amount of Lactobacillus/phenol mixture or lyophilized mixture. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/120670 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 9/0053 (20130101) A61K 35/747 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293622 | Arvik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SONOMACEUTICALS, LLC (Santa Rosa, California); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Torey James Arvik (Santa Rosa, California); Hyunsook Kim (Seoul, South Korea); Wallace H. Yokoyama (Albany, California); Scott R. Forsberg (Santa Rosa, California) |
| ABSTRACT | Embodiments described herein provide for uses of grape products, such as Chardonnay grape products and grape seed flour, for use in promoting a healthy liver, promoting healthy fat content in a liver, for treating or preventing NAFLD, and other embodiments and uses as described herein. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063281 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 36/28 (20130101) A61K 36/79 (20130101) A61K 36/87 (20130101) Original (OR) Class A61K 36/9066 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296017 | CARDIFF |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin) |
| INVENTOR(S) | MICHAEL CARDIFF (MADISON, Wisconsin) |
| ABSTRACT | A system for monitoring and establishing physical properties of a subsurface formation at a testing site having a source well and one or more receiver wells may include a pump, a data collection system, and a controller. The controller may cause the pump to extract fluid from and inject fluid into the source well based on one or more measures indicative of an amount of liquid in the source well. The controller may receive measures related to pressures in the receiver wells and physical properties of the subsurface formation may be determined based on the measures related to pressures in the receiver well. In some cases, noise may be removed from the measures related to pressures in the receiver wells to facilitate determining the physical properties of the subsurface formation. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/121904 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/12 (20130101) E21B 49/008 (20130101) Original (OR) Class E21B 2200/20 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230296287 | Archuleta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Geronimo Archuleta (Pilot Rock, Oregon); Benjamin Kaiser (Portland, Oregon); Emily Dawson (Portland, Oregon) |
| ABSTRACT | A floor cassette for a housing module includes a base that is sized to fit under a floor of the modular housing unit. The floor cassette also includes a perimeter drain incorporated into a perimeter of the base, where the perimeter drain comprises a cavity designed to collect liquid from the floor of the modular housing unit. The cavity of the perimeter drain also comprises an air duct that delivers heated or cooled air to the modular housing unit. |
| FILED | Tuesday, February 14, 2023 |
| APPL NO | 18/109368 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 13/222 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230293499 | RISHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia); Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ARUN K. RISHI (Troy, Michigan); NAVNATH GAVANDE (Detroit, Michigan) |
| ABSTRACT | Described herein are compositions and methods for treating cancer in a subject. The compositions include selective NF-κB inhibitor inhibitors. The methods include inhibiting the binding of CARP-1 with NEMO. |
| FILED | Friday, January 27, 2023 |
| APPL NO | 18/160897 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/282 (20130101) A61K 31/427 (20130101) Original (OR) Class A61K 31/704 (20130101) A61K 31/4164 (20130101) A61K 47/557 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230293551 | Ren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Durect Corporation (Cupertino, California); Virginia Commonwealth University (Richmond, Virginia); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shunlin Ren (Richmond, Virginia); Yaping Wang (Richmond, Virginia); WeiQi Lin (Emerald Hills, California) |
| ABSTRACT | Aspects of the present disclosure include methods for treating at least one autoimmune condition, such as at least one of hepatitis, multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. In some cases, the at least one autoimmune condition is associated with Epstein-Barr virus infection. In practicing the subject methods, an effective amount of at least one compound selected from 25-hydroxycholesterol-3-sulfate (25HC3S), 25-hydroxycholesterol-disulfate (25HCDS), 27-hydroxycholesterol-3-sulfate (27HC3S), 27-hydroxycholesterol-disulfate (27HCDS), 24-hydroxycholesterol-3-sulfate (24HC3S), 24-hydroxycholesterol-disulfate (24HCDS), and 24,25-epoxycholesterol-3-sulfate, or salt thereof is administered to the subject. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 18/008582 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/575 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230298874 | Cooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Dalton Snyder (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for performing multiple precursor, neutral loss and product ion scans in a single ion trap. In certain aspects, the invention provides systems including a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply at least one of the following ion scans to a single ion population in the single ion trap: multiple precursor ion scans, a plurality of segmented neutral loss scans, or multiple simultaneous neutral loss scans. |
| FILED | Tuesday, May 02, 2023 |
| APPL NO | 18/142212 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/004 (20130101) H01J 49/0013 (20130101) H01J 49/0027 (20130101) Original (OR) Class H01J 49/0081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230299361 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Chuanlong Wang (Hanover, New Hampshire); Weiyang LI (Hanover, New Hampshire) |
| ABSTRACT | In an embodiment, the present disclosure pertains to an electrolyte composition including a plurality of ether-based solvents and at least one sodium-based salt. The plurality of ether-based solvents include at least one acyclic ether and at least one cyclic ether. In a further embodiment, the present disclosure pertains to an energy storage device that includes an electrolyte composition of the present disclosure. In another embodiment, the present disclosure pertains to a method of making the electrolyte compositions of the present disclosure. Such methods generally include one or more of the following steps of mixing a plurality of ether-based solvents and at least one sodium-based salt, and forming the electrolyte composition. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 18/019757 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/381 (20130101) H01M 10/054 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2004/027 (20130101) H01M 2300/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230294644 | Del Gizzi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stratom, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Del Gizzi (Arvada, Colorado); Broc Sommermeyer (Windsor, Colorado); Kristin Farris (Arvada, Colorado); Zachary Allen (Superior, Colorado); Ross Wehner (Erie, Colorado); Mark Gordon (Lafayette, Colorado) |
| ABSTRACT | Systems and techniques are provided for autonomous or semi-autonomous connection and disconnection of an end effector to a port, such as a refueling port associated with a fuel tank. The end effector may be coupled with a carriage system, such as a robotic arm and have a connection with a supply source. A sensor suite may be coupled with the carriage system and output optical and/or proximity data that is received at a controller system. The controller system may identify a location of the port, position the end effector in proximity with the port, and provide a connection therebetween. The controller system may identify a fiducial target associated with the port that provides for alignment with the end effector and port. The end effector may also include a compensation system to adjust a location of the end effector to a finer degree than is possible using the carriage system. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/700425 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1697 (20130101) Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 5/02 (20130101) Original (OR) Class Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230295626 | PLACE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | miRecule, Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert PLACE (Gaithersburg, Maryland); Anthony SALEH (Gaithersburg, Maryland); Tishan WILLIAMS (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155163 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 47/549 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/33 (20130101) C12N 2310/141 (20130101) C12N 2310/316 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/351 (20130101) C12N 2310/531 (20130101) C12N 2310/3521 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) C12N 2320/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230294103 | Gaume et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | Romain Gaume (Lake Mary, Florida); Matthew Julian (Merritt Island, Florida) |
| ABSTRACT | A method can include milling a powder with a test grinding media, and determining an amount of abraded grinding media that abrades from the test grinding media into the powder due to the milling of the powder. The method can include creating a compensated powder to account for the amount of the abraded grinding media such that the powder milling process results in a desired powder composition. |
| FILED | Friday, March 17, 2023 |
| APPL NO | 18/122833 |
| CURRENT CPC | Crushing, Pulverising, or Disintegrating in General; Milling Grain B02C 17/20 (20130101) B02C 17/1805 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20230295606 | FORST et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arc Bio, LLC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jannine FORST (San Jose, California); Morten RASMUSSEN (Mountain View, California); Stephane B. GOURGUECHON (San Mateo, California) |
| ABSTRACT | Provided herein are compositions and methods for generating libraries for high throughput sequencing without using ligation, and methods of using same. |
| FILED | Monday, November 30, 2020 |
| APPL NO | 17/782841 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class C12N 15/1068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20230296380 | McBride et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sterling Eduardo McBride (Princeton, New Jersey); Alan M. Braun (Princeton, New Jersey); Seth Charles Caliga (Lafayette, Colorado) |
| ABSTRACT | An assembly includes one or more high temperature vapor cells positioned along an axis of the assembly, a vacuum envelope encasing the one or more high temperature vapor cells, and one or more sets of low thermal conductivity mounting structures coupled to the vacuum envelope. Each set of low thermal conductivity mounting structures is configured to position a corresponding one of the high temperature vapor cells within the vacuum envelope. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 18/041053 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/62 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20230296017 | CARDIFF |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin) |
| INVENTOR(S) | MICHAEL CARDIFF (MADISON, Wisconsin) |
| ABSTRACT | A system for monitoring and establishing physical properties of a subsurface formation at a testing site having a source well and one or more receiver wells may include a pump, a data collection system, and a controller. The controller may cause the pump to extract fluid from and inject fluid into the source well based on one or more measures indicative of an amount of liquid in the source well. The controller may receive measures related to pressures in the receiver wells and physical properties of the subsurface formation may be determined based on the measures related to pressures in the receiver well. In some cases, noise may be removed from the measures related to pressures in the receiver wells to facilitate determining the physical properties of the subsurface formation. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/121904 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/12 (20130101) E21B 49/008 (20130101) Original (OR) Class E21B 2200/20 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230296791 | Koohi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anoosha Koohi (Mclean, Virginia); Charles P. McLellan (Fairfax, Virginia) |
| ABSTRACT | A system and method for improving accuracy of a mobile delivery device traversing a route. The system includes a mobile delivery device, a geolocation circuit and an inertial navigation system in communication with the mobile device, and a processor configured to compare accuracy indicators to thresholds to determine when to switch sensing the position of the mobile delivery device between the geolocation circuit and the inertial navigation system. |
| FILED | Friday, March 17, 2023 |
| APPL NO | 18/186104 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/47 (20130101) G01S 19/396 (20190801) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/08355 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230299809 | Hayslett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Tyler M. Hayslett (Nashua, New Hampshire); Christopher Alix (Barrington, New Hampshire); Nathan Alix (Epsom, New Hampshire); Timothy Del Signore (Brookline, New Hampshire); Eric G. Schneider (Brookline, New Hampshire); Christopher A. Straw (Fremont, New Hampshire); Michael A. Young (Nashua, New Hampshire) |
| ABSTRACT | A transceiver unit includes an enclosure, a first input port, a second input port, a first output port, and a second output port. A radio frequency (RF) pass-through path is within the enclosure between the first input port and the first output port and includes a gain module. The RF pass-through path is configured to receive a first RF signal at the first input port and to transmit a second RF signal at the first output port. The gain module is configured to amplify the first RF signal to produce the second RF signal. The transceiver unit further includes a transceiver path within the enclosure between the second input port and the second output port, the transceiver path including a signal processor. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/655586 |
| CURRENT CPC | Transmission H04B 1/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, September 21, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230921.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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