FedInvent™ Patents

Patent Details for Tuesday, March 07, 2023

This page was updated on Wednesday, March 08, 2023 at 04:17 AM GMT

Department of Health and Human Services (HHS)

11596339 — Determining intended user movement to control an external device

US 11596339	Lukyanenko et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S)	Platon Lukyanenko (Shaker Heights, Ohio); Matthew R. Williams (Cleveland, Ohio); Dustin J. Tyler (Highland Heights, Ohio)
ABSTRACT	A user-specific model of muscular activity can be used to control an external device based on muscular activity within a limb of a user. The user-specific model of muscular activity can include single movements and corresponding one or more primary muscle patterns. New single movements can be added to the user-specific model of muscular activity can be by a system that includes a processor by receiving user-specific EMG signals (including one or more EMG patterns that indicate a single movement); decomposing the user-specific EMG signals into the one or more EMG patterns in EMG feature space that indicate the single movement; and updating the user-specific model of muscular activity to include the single movement and corresponding one or more primary muscle patterns based on the one or more EMG patterns in EMG feature space.
FILED	Friday, March 13, 2020
APPL NO	16/818185
ART UNIT	2622 — Selective Visual Display Systems
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/296 (20210101) Original (OR) Class A61B 5/4851 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) Electric Digital Data Processing G06F 3/015 (20130101)
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11596367 — Electromagnetic tracking system and methods of using same

US 11596367	Siewerdsen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S)	Jeffrey H. Siewerdsen (Baltimore, Maryland); Jongheun Yoo (Baltimore, Maryland)
ABSTRACT	An electromagnetic tracking system including a patient support element and an electromagnetic field generator. The patient support element is superposed relative to the electromagnetic field generator, and the electromagnetic field generator is selectively moveable relative to the patient support element.
FILED	Tuesday, January 14, 2020
APPL NO	16/742034
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/061 (20130101) A61B 6/032 (20130101) A61B 6/0407 (20130101) Original (OR) Class A61B 6/508 (20130101) A61B 6/547 (20130101) A61B 6/582 (20130101) A61B 6/583 (20130101) A61B 6/4085 (20130101) A61B 6/4405 (20130101) A61B 6/4423 (20130101) A61B 6/4441 (20130101) A61B 34/20 (20160201) A61B 2034/2051 (20160201) Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 13/04 (20130101) A61G 2200/322 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/028 (20130101)
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11596411 — Aortic flow meter and pump for partial-aortic occlusion

US 11596411	Johnson et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California); Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Michael Austin Johnson (Sacramento, California); Timothy K. Williams (Travis AFB, California); Lucas Paul Neff (Decatur, Georgia)
ABSTRACT	Systems and methods for partial aortic occlusion are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient, and a catheter controller unit that causes the device to expand and contract to restrict blood flow through the aorta. The system also may include sensors for measuring blood pressure distal and proximal to the expandable device. The system further may include non-transitory computer readable media having instructions stored thereon, wherein the instructions, when executed by a processor coupled to the sensors, cause the processor to estimate aortic blood flow based on the measured blood pressures and corresponding waveforms, compare the estimated aortic blood flow with a target aortic blood flow range, generate an alert if the estimated aortic blood flow falls outside the target aortic blood flow range, and cause the catheter controller unit to adjust expansion and contraction of the expandable device to adjust an amount of blood flow through the aorta if the estimated aortic blood flow falls outside the target aortic blood flow range.
FILED	Friday, October 18, 2019
APPL NO	16/657588
ART UNIT	3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/12036 (20130101) Original (OR) Class A61B 17/12109 (20130101) A61B 17/12136 (20130101) A61B 2017/00022 (20130101) A61B 2017/00119 (20130101) A61B 2017/00199 (20130101) A61B 2017/00221 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/10182 (20131105) A61M 2205/18 (20130101) A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/3334 (20130101) A61M 2210/127 (20130101) A61M 2230/04 (20130101) A61M 2230/30 (20130101) A61M 2230/42 (20130101) A61M 2230/50 (20130101)
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11596512 — Decellularized biologically-engineered tubular grafts

US 11596512	Tranquillo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Robert Tranquillo (Arden Hills, Minnesota); Zeeshan Syedain (Minneapolis, Minnesota); Lee Meier (Minneapolis, Minnesota)
ABSTRACT	This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts.
FILED	Thursday, December 31, 2020
APPL NO	17/139575
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/04 (20130101) A61F 2/06 (20130101) Original (OR) Class A61F 2/062 (20130101) A61F 2/2412 (20130101) A61F 2/2415 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/36 (20130101) A61L 27/507 (20130101) A61L 27/3604 (20130101) A61L 27/3633 (20130101) A61L 27/3695 (20130101) A61L 2430/40 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 23/00 (20130101)
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11596547 — Hydrodissection and posterior capsule opacification prevention during capsulotomy procedure

US 11596547	Keller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Centricity Vision, Inc. (Fremont, California)
ASSIGNEE(S)	CENTRICITY VISION, INC. (Carlsbad, California)
INVENTOR(S)	Christopher Guild Keller (El Cerrito, California); Thomas Haynes McGaffigan (Saratoga, California); Kevin L. Waltz (Indianapolis, Indiana); Thomas Milton McNicholas (Laguna Niguel, California)
ABSTRACT	Embodiments of the invention provide hydrodissection and/or PCO prevention or reduction in a patient undergoing eye surgery. In one embodiment, the invention is a surgical device for cutting and excising a portion of tissue, for example in performing a lens capsulotomy. A capsulotomy tip is inserted into an eye through an incision in the surface of the eye. The capsulotomy tip includes a suction cup to provide suction to the lens capsule. Then suction is applied via the suction cup to secure the capsulotomy tip to the eye. In some embodiments, after the capsulotomy tip is secured to the lens capsule, a cutting element of the capsulotomy tip is used to cut a tissue of the eye. Fluid is pushed through the capsulotomy tip and the capsulotomy tip is removed from the eye. Moreover, disclosed is an intraocular lens (IOL) to be used in conjunction with the surgical device.
FILED	Friday, January 25, 2019
APPL NO	16/257477
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/08 (20130101) A61B 2018/00291 (20130101) A61B 2018/00321 (20130101) A61B 2018/00601 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/16 (20130101) A61F 9/008 (20130101) A61F 9/00754 (20130101) Original (OR) Class A61F 2009/00889 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/77 (20210501)
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11596548 — Device for automated capsulotomy

US 11596548	Keller
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Centricity Vision, Inc. (Fremont, California)
ASSIGNEE(S)	CENTRICITY VISION, INC. (Carlsbad, California)
INVENTOR(S)	Christopher Guild Keller (El Cerrito, California)
ABSTRACT	A surgical device is disclosed for cutting tissue, including for performing a capsulotomy of a lens capsule of an eye. This device includes a reversibly collapsible cutting element for cutting a portion of a capsule membrane of the eye. The cutting element includes an outer layer, an inner layer, and a bottom layer that has a higher electrical resistance than the electrical resistance of the outer layer and the inner layer. The bottom layer is configured to conduct an electrical current between the outer layer and the inner layer, which causes a temperature increase in the bottom layer for cutting tissue.
FILED	Friday, June 14, 2019
APPL NO	16/440999
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/082 (20130101) A61B 2018/00107 (20130101) A61B 2018/00321 (20130101) A61B 2018/00601 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0079 (20130101) A61F 9/00754 (20130101) Original (OR) Class
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11596599 — Compositions and methods for ophthalmic and/or other applications

US 11596599	Popov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Alexey Popov (Waltham, Massachusetts); Elizabeth M. Enlow (Waltham, Massachusetts); Hongming Chen (Belmont, Massachusetts); James Bourassa (Somerville, Massachusetts)
ABSTRACT	Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.
FILED	Monday, February 08, 2021
APPL NO	17/170701
ART UNIT	1616 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) Original (OR) Class A61K 9/5031 (20130101) A61K 9/5123 (20130101) A61K 9/5138 (20130101) A61K 9/5146 (20130101) A61K 31/56 (20130101)
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11596605 — Particles for delivery of proteins and peptides

US 11596605	Loscalzo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S)	Joseph Loscalzo (Dover, Massachusetts); Ying-Yi Zhang (Quincy, Massachusetts)
ABSTRACT	The present application provides a method of making a particle comprising (i) obtaining a first solution comprising a negatively charged polysaccharide; (ii) obtaining a second solution comprising a positively charged polysaccharide; and (iii) mixing the first solution and the second solution to obtain a suspension comprising the particle. The present application also provides a method of making a therapeutic particle, comprising: (i) obtaining a solution comprising a therapeutic protein; (ii) obtaining a first suspension comprising the particle comprising a negatively charged polysaccharide and a positively charged polysaccharide, and (iii) mixing the solution of the therapeutic protein and the first suspension to obtain a second suspension comprising the therapeutic particle. The present application also provides particles (e.g., therapeutic particles) prepared by any one of the disclosed methods, as well as the compositions comprising such particles, and methods of treating a disease or condition using such particles and compositions.
FILED	Tuesday, August 01, 2017
APPL NO	16/322669
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1652 (20130101) A61K 9/1676 (20130101) Original (OR) Class A61K 38/47 (20130101) A61K 38/185 (20130101) A61K 38/195 (20130101) A61K 38/204 (20130101) A61K 38/1825 (20130101) A61K 38/1866 (20130101) A61K 38/1875 (20130101) A61K 47/61 (20170801) A61K 47/6941 (20170801)
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11596613 — Compositions and methods for treating cancer

US 11596613	Schultz et al.
FUNDED BY	Department of Homeland Security (DHS) Countering Weapons of Mass Destruction Office (CWMD) Domestic Nuclear Detection Office (DNDO) National Nuclear Forensics Expertise Development Program (NNFEDP) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
ASSIGNEE(S)	UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
INVENTOR(S)	Michael K. Schultz (Iowa City, Iowa); Somya Kapoor (Iowa City, Iowa); Douglas R. Spitz (Iowa City, Iowa)
ABSTRACT	The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
FILED	Friday, July 31, 2020
APPL NO	16/945327
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/66 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/192 (20130101) A61K 31/437 (20130101) A61K 31/437 (20130101) A61K 31/662 (20130101) A61K 31/662 (20130101) A61K 31/4706 (20130101) A61K 31/4706 (20130101) A61K 39/3955 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 2317/21 (20130101)
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11596615 — Compositions and methods for treatment of insulin resistance

US 11596615	Merali et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Temple University Of The Commonwealth System Of Higher Education (Philadelphia, Pennsylvania)
ASSIGNEE(S)	TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Philadelphia, Pennsylvania)
INVENTOR(S)	Salim Merali (Philadelphia, Pennsylvania); Carlos A. Barrero (Philadelphia, Pennsylvania); Wayne E. Childers (New Hope, Pennsylvania); George C. Morton (Collegeville, Pennsylvania)
ABSTRACT	Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R¹-R¹⁴, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
FILED	Friday, July 17, 2020
APPL NO	16/932236
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101)
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11596636 — Tailored combinatorial epigenetic therapies for P53 gain-of-function tumors

US 11596636	Berger et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Shelley L. Berger (Wayne, Pennsylvania); Xianxin Hua (Wynnewood, Pennsylvania); Morgan Sammons (Philadelphia, Pennsylvania); Jiajun Zhu (Philadelphia, Pennsylvania)
ABSTRACT	The present invention provides compositions and methods for treating and preventing cancer. The invention comprises an inhibitor of epigenetic regulators, including MLL1, MLL2, MOZ, menin, WDR5, or a combination thereof. In one embodiment, the invention provides a personalized method of treating a cancer as dependent upon its epigenetic signature.
FILED	Wednesday, January 14, 2015
APPL NO	15/110967
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/136 (20130101) A61K 31/519 (20130101) A61K 31/713 (20130101) A61K 31/5377 (20130101) Original (OR) Class
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11596639 — Substituted indole Mcl-1 inhibitors

US 11596639	Lee et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) Frederick National Laboratory for Cancer Research (FNLCR) Federally Funded Research and Development Center (FFRDC) Operated by Leidos Biomedical Research, Inc. (LBRI) at Frederick, MD NIH Office of the Director (NIHOD)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Taekyu Lee (Brentwood, Tennessee); James C. Tarr (Franklin, Tennessee); KyuOk Jeon (Nashville, Tennessee); James M. Salovich (Nashville, Tennessee); Subrata Shaw (Nashville, Tennessee); Nagarathanam Veerasamy (Nashville, Tennessee); Kwangho Kim (Nashville, Tennessee); Plamen P. Christov (Mount Juliet, Tennessee); Edward T. Olejniczak (Nashville, Tennessee); Bin Zhao (Brentwood, Tennessee); Stephen W. Fesik (Nashville, Tennessee); Zhiguo Bian (Lake Bluff, Illinois)
ABSTRACT	The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
FILED	Friday, March 03, 2017
APPL NO	16/081709
ART UNIT	1699 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/538 (20130101) A61K 31/551 (20130101) Original (OR) Class A61K 31/4985 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 403/14 (20130101) C07D 487/04 (20130101) C07D 519/00 (20130101)
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11596675 — Combination immunotherapy compositions against cancer and methods

US 11596675	Hodge et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	GLOBEIMMUNE, INC. (Louisville, Colorado); The USA, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	GlobeImmune, Inc. (Louisville, Colorado); The USA, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	James Hodge (Kensington, Maryland); Jeffrey Schlom (Potomac, Maryland); Alex Franzusoff (Los Altos, California)
ABSTRACT	Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
FILED	Wednesday, November 18, 2020
APPL NO	16/951739
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/00117 (20180801) A61K 39/001102 (20180801) A61K 39/001104 (20180801) A61K 39/001106 (20180801) A61K 39/001151 (20180801) A61K 39/001152 (20180801) A61K 39/001156 (20180801) A61K 39/001157 (20180801) A61K 39/001162 (20180801) A61K 39/001164 (20180801) A61K 39/001168 (20180801) A61K 39/001182 (20180801) A61K 39/001184 (20180801) A61K 39/001186 (20180801) A61K 39/001188 (20180801) A61K 39/001191 (20180801) A61K 39/001192 (20180801) A61K 39/001194 (20180801) A61K 39/001195 (20180801) A61K 2039/523 (20130101) A61K 2039/55522 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101)
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11596677 — Induction of protective immunity against antigens

US 11596677	Curtiss, III et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	University of Florida Research Foundation, Incorporated (Gainsville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Roy Curtiss, III (Gainesville, Florida); Shifeng Wang (Gainesville, Florida)
ABSTRACT	Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens from Clostridium Perfringens as vaccines to prevent necrotic enteritis (NE).
FILED	Friday, August 03, 2018
APPL NO	16/636251
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/08 (20130101) Original (OR) Class A61K 2039/523 (20130101) A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101)
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11596679 — Hepatitis C virus gene sequences and methods of use therefor

US 11596679	Crowe, Jr. et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
INVENTOR(S)	James E. Crowe, Jr. (Nashville, Tennessee); Andrew Flyak (Nashville, Tennessee); Justin Bailey (Baltimore, Maryland); Stuart Ray (Baltimore, Maryland); George Shaw (Philadelphia, Pennsylvania)
ABSTRACT	The present disclosure relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present disclosure provides a composition comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof.
FILED	Friday, April 27, 2018
APPL NO	16/608308
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 39/29 (20130101) A61K 39/39 (20130101) A61K 2039/53 (20130101) A61K 2039/5258 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101)
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11596682 — Autologous and allogenic HIV-1 proteins for the treatment of latent HIV-1 infection

US 11596682	Arts et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S)	Eric J. Arts (Ontario, Canada); Jamie Mann (Ontario, Canada)
ABSTRACT	A method of reducing a latent HIV-specific memory-CD4+ T cell pool in a subject includes administering to the subject at least one HIV-1 protein and a pharmaceutically acceptable carrier, wherein the at least one HIV-1 protein is derived from an allogenic infecting HIV-1 virus, and wherein the HIV-1 protein stimulates latent HIV-specific memory CD4+ T cells to induce latent HIV-1 replication resulting in HIV-specific memory-CD4+ T cell death in the subject.
FILED	Tuesday, December 08, 2020
APPL NO	17/115355
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 45/06 (20130101) A61K 2039/572 (20130101) A61K 2039/6075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16034 (20130101) C12N 2740/16134 (20130101)
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11596683 — Engineered influenza polynucleotides, viruses, vaccines and methods of making and using the same

US 11596683	Heaton et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Nicholas Scott Heaton (Durham, North Carolina); Alfred Theodore Harding (Durham, North Carolina); Brook Elizabeth Heaton (Durham, North Carolina)
ABSTRACT	Engineered Influenza polynucleotides, viruses, vaccines, and methods of making and using the same are provided. More specifically, the present inventors have developed replication competent engineered influenza viruses having, for example, a modified segment 4 and/or segment 6 that include at least one additional polynucleotide encoding a heterologous polypeptide.
FILED	Wednesday, July 12, 2017
APPL NO	16/317427
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/5252 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 14/00 (20130101) C07K 14/005 (20130101) C07K 14/11 (20130101) C07K 2319/42 (20130101) C07K 2319/50 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/2402 (20130101) C12N 15/86 (20130101) C12N 2760/16121 (20130101) C12N 2760/16122 (20130101) C12N 2760/16134 (20130101) C12N 2760/16143 (20130101) Enzymes C12Y 302/01018 (20130101)
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11596691 — Photoswitchable HDAC inhibitors

US 11596691	Mazitschek et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Ralph Mazitschek (Belmont, Massachusetts); Balaram Ghosh (Boston, Massachusetts); James Adam Hendricks (Watertown, Massachusetts); Surya Reis (Boston, Massachusetts); Stephen John Haggarty (Dorchester, Massachusetts)
ABSTRACT	This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
FILED	Friday, November 06, 2020
APPL NO	17/091863
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 41/0028 (20130101) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 245/08 (20130101) C07C 259/06 (20130101) C07C 259/10 (20130101) Heterocyclic Compounds C07D 333/20 (20130101) C07D 409/14 (20130101) C07D 491/16 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/022 (20130101)
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11596700 — Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder

US 11596700	Goldman
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	University of Rochester (Rochester, New York)
ASSIGNEE(S)	UNIVERSITY OF ROCHESTER (Rochester, New York)
INVENTOR(S)	Steven A. Goldman (Webster, New York)
ABSTRACT	The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and restoring normal brain interstitial potassium levels.
FILED	Friday, February 10, 2017
APPL NO	15/429559
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) A01K 2207/12 (20130101) A01K 2207/15 (20130101) A01K 2227/105 (20130101) A01K 2267/0318 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) A61K 35/545 (20130101) A61K 45/06 (20130101) A61K 49/0008 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/06 (20130101) C12N 5/0622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101) G01N 33/5085 (20130101) G01N 2800/28 (20130101) G01N 2800/2814 (20130101) G01N 2800/2821 (20130101) G01N 2800/2835 (20130101)
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11596718 — Layer by layer coated mesh for local release of bio-active proteins

US 11596718	Brown et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
INVENTOR(S)	Bryan Nicklaus Brown (Pittsburgh, Pennsylvania); Daniel Jordi Hachim Diaz (Pittsburgh, Pennsylvania)
ABSTRACT	The present invention relates to biomaterials coated with an active agent eluting coating, wherein implantation of the coated biomaterial results in reduced implant-related complications and/or improved integration of the biomaterial into the host tissue and further relates to kits containing the coated biomaterial. The present invention also relates to methods and kits for coating the biomaterial. It is based, at least in part, on the discovery that biomaterial coated with a cytokine eluting coating resulted in the shift of early stage macrophage polarization that were associated with positive long-term effects such as minimized capsule formation and improved tissue quality and composition as compared to uncoated biomaterials.
FILED	Friday, December 04, 2020
APPL NO	17/111704
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/0063 (20130101) A61F 2210/0076 (20130101) A61F 2250/0067 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/2026 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/44 (20130101) A61L 17/005 (20130101) A61L 17/145 (20130101) A61L 27/34 (20130101) A61L 27/54 (20130101) A61L 29/16 (20130101) A61L 29/085 (20130101) A61L 31/10 (20130101) A61L 31/16 (20130101) A61L 31/048 (20130101) Original (OR) Class A61L 31/048 (20130101) A61L 2420/02 (20130101) A61L 2420/08 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 31/002 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/18 (20130101) B05D 1/36 (20130101) B05D 7/56 (20130101) Compositions of Macromolecular Compounds C08L 23/10 (20130101)
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11596779 — Drug delivery methods and systems

US 11596779	Tong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	MORNINGSIDE VENTURE INVESTMENTS LIMITED (Monaco, Monaco)
ASSIGNEE(S)	Morningside Venture Investments Limited (Monaco, Monaco)
INVENTOR(S)	Ling-Kang Tong (Hayward, California); Daniela Tamar Buchman (Mountain View, California); Jackie Joe Hancock (Berkeley, California); Nicholas Terzulli (Oakland, California)
ABSTRACT	A two-part bioactive agent delivery system includes a disposable part, a reusable part, and a solvent removal element. The disposable part includes an agent reservoir, a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user. The transdermal patch has a bottom surface adapted to contact skin of the user, a top surface opposite the bottom surface, and a gas permeable membrane disposed over the top surface of the transdermal patch. The reusable part includes a power source and control electronics that are adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch. The solvent removal element includes a gap disposed between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system.
FILED	Wednesday, May 29, 2019
APPL NO	17/057318
ART UNIT	3781 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 35/10 (20190501) Original (OR) Class A61M 2205/14 (20130101) A61M 2205/0272 (20130101) A61M 2205/8206 (20130101)
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11596786 — Vestibular stimulation device

US 11596786	Risi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	Cochlear Limited (Macquarie University, Australia); University of Washington Center for Commercialization (Seattle, Washington)
ASSIGNEE(S)	Cochlear Limited (Macquarie University, Australia); University of Washington Center for Commercialization (Seattle, Washington)
INVENTOR(S)	Frank Risi (Newtown, Australia); Colin Irwin (Nice, France); Jay T. Rubinstein (Seattle, Washington); Felipe Santos (Boston, Massachusetts); James O. Phillips (Seattle, Washington)
ABSTRACT	A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures.
FILED	Monday, January 11, 2021
APPL NO	17/145583
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/361 (20130101) A61N 1/0526 (20130101) Original (OR) Class A61N 1/0551 (20130101)
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11596787 — Peripheral nerve electrode for neural recording and stimulation

US 11596787	Cogan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Stuart F. Cogan (Dallas, Texas); Atefeh Ghazavi (Dallas, Texas); Alexandra Joshi-Imri (Richardson, Texas)
ABSTRACT	A bioelectric interface is provided. The bioelectric interface comprises a case having a channel configured to hold a nerve. An electrode array is slidably coupled to the case, wherein the electrode array comprises a number of electrode shanks. The case restricts movement of the electrode array to one degree of freedom toward or away from the nerve held in the channel for insertion of the electrode shanks into the nerve.
FILED	Monday, March 30, 2020
APPL NO	16/835180
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0556 (20130101) Original (OR) Class A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 1/36096 (20130101) A61N 1/36117 (20130101)
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11596812 — Wearable transcranial dual-mode ultrasound transducers for neuromodulation

US 11596812	Ebbini
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
INVENTOR(S)	Emad S. Ebbini (Edina, Minnesota)
ABSTRACT	An ultrasound transducer array is incorporated in a light-weight, conformable, and wearable patch that may be used to deliver, monitor, and control localized transcranial focused ultrasound (tFUS). The patch may include full-duplex transmit-receive circuitry that may be used for continuous monitoring of transcranial focused ultrasound (tFUS) application. The circuitry may include a circulator. The ultrasound transducer array may be coupled to an aperture interface having irregularly sized or shaped channel conductors to provide a coarse aperture for the array. The coarse aperture may be designed using a method that provides a reduced channel count.
FILED	Friday, April 05, 2019
APPL NO	16/376139
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/4494 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/006 (20130101) A61N 2007/0026 (20130101) A61N 2007/0052 (20130101) A61N 2007/0086 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0688 (20130101)
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11597697 — Therapeutic DNP derivatives and methods using same

US 11597697	Shulman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)	YALE UNIVERSITY (New Haven, Connecticut)
INVENTOR(S)	Gerald I. Shulman (East Haven, Connecticut); David A. Spiegel (New Haven, Connecticut)
ABSTRACT	The present invention includes DNP derivatives that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent.
FILED	Tuesday, April 05, 2022
APPL NO	17/713759
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/085 (20130101) Acyclic or Carbocyclic Compounds C07C 205/37 (20130101) Original (OR) Class Steroids C07J 41/0055 (20130101)
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11597715 — Inhibitors of dihydroceramide desaturase for treating disease

US 11597715	Romero et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Centaurus Therapeutics (Half Moon Bay, California)
ASSIGNEE(S)	Centaurus Therapeutics (San Francisco, California)
INVENTOR(S)	Donna L. Romero (San Francisco, California); Jeremy Blitzer (San Francisco, California)
ABSTRACT	Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic disorders, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided.
FILED	Friday, January 11, 2019
APPL NO	16/959807
ART UNIT	1622 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 213/75 (20130101) C07D 213/76 (20130101) C07D 241/04 (20130101) C07D 401/04 (20130101) C07D 401/12 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 405/12 (20130101)
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11597727 — Inhibitors of integrin alpha 2 beta 1 and methods of use

US 11597727	Sheppard et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Dean Sheppard (Oakland, California); Aparna Sundaram (San Francisco, California); William F. DeGrado (San Francisco, California); Hyunil Jo (Lafayette, California)
ABSTRACT	Disclosed herein, inter alia, are inhibitors of integrin alpha 2 beta 1 and methods of using the same.
FILED	Wednesday, March 13, 2019
APPL NO	16/979096
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 275/24 (20130101) C07C 275/26 (20130101) C07C 2602/08 (20170501) C07C 2602/10 (20170501) C07C 2602/42 (20170501) C07C 2603/74 (20170501) Heterocyclic Compounds C07D 207/48 (20130101) C07D 213/81 (20130101) C07D 277/06 (20130101) C07D 471/08 (20130101) Original (OR) Class
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11597735 — Highly efficient free radical photopolymerizations through enabled dark cure

US 11597735	Stansbury et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO (Boulder, Colorado)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado)
INVENTOR(S)	Jeffrey W. Stansbury (Boulder, Colorado); Kangmin Kim (Boulder, Colorado); Charles B. Musgrave (Boulder, Colorado); Jasmine Sinha (Boulder, Colorado)
ABSTRACT	A quaternary ammonium salt comprising a chromophore constituent, a tertiary amine cation constituent connected to the para-position of the chromophore constituent via a methylene linkage, and a borate anion constituent, wherein chromophore constituent is a 3-ketocoumarin constituent or a benzophenone constituent. Also, a photobase-redox initiating system comprising the quaternary ammonium salt and a peroxide.
FILED	Monday, December 10, 2018
APPL NO	16/770725
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 311/16 (20130101) C07D 311/56 (20130101) C07D 311/92 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/027 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/50 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/029 (20130101) G03F 7/0045 (20130101)
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11597743 — Glycosyltransferase inhibitors for treatment of solid tumors

US 11597743	Clemons et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Memphis, Tennessee)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Memphis, Tennessee)
INVENTOR(S)	William M. Clemons (Colliervielle, California); Michio Kurosu (Memphis, Tennessee)
ABSTRACT	The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I. Also provided are methods of inhibiting dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of a compound of Formula I:
FILED	Friday, January 11, 2019
APPL NO	16/960608
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/7072 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 19/06 (20130101) Original (OR) Class
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11597749 — Peptide compositions and methods of use

US 11597749	Besirli et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	ONL Therapeutics, Inc. (Ann Arbor, Michigan); The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); ONL THERAPEUTICS, INC. (Ann Arbor, Michigan)
INVENTOR(S)	Cagri G. Besirli (Ann Arbor, Michigan); Alexander J. Bridges (Saline, Michigan); John K. Freshley (Ann Arbor, Michigan); William A. Hunke (Middletown, Delaware); Linda L. Johnson (Ann Arbor, Michigan); Francis X. Smith (Salem, New Hampshire); Ethan Sylvain (Manchester, New Hampshire); David N. Zacks (Ann Arbor, Michigan)
ABSTRACT	Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.
FILED	Tuesday, October 06, 2020
APPL NO	17/064495
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class C07K 14/71 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101)
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11597751 — Glycan-binding proteins and related compositions and methods

US 11597751	Imperiali et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Barbara Imperiali (Cambridge, Massachusetts); Cristina Zamora (Medford, Massachusetts); Elizabeth Ward (Somerville, Massachusetts)
ABSTRACT	Glycan-binding proteins, and compositions thereof, are generally described, including methods of making and using such proteins. The proteins may include scaffolds based on easily evolvable DNA-binding proteins, with binding sites able to specifically bind to mono- or disaccharides, such as monosaccharide-binding determinants, disaccharide-binding determinants, more complex carbohydrates, etc. In certain aspects, a protein may be generated starting from a small DNA-binding protein, such as Sso7d. Such glycan-binding proteins may have numerous applications, including in enzyme-linked immunosorbent assays (ELISAs), glycan characterization, cell selection, flow cytometry, histology, imaging, arrays, affinity purification, enzyme-linked visualization, binding to a target for pharmaceutical purposes, etc.
FILED	Friday, March 13, 2020
APPL NO	16/818827
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/47 (20130101) Original (OR) Class
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11597754 — Use of the CD2 signaling domain in second-generation chimeric antigen receptors

US 11597754	June et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Carl H. June (Merion Station, Pennsylvania); John Scholler (Narberth, Pennsylvania); Avery D. Posey, Jr. (Philadelphia, Pennsylvania)
ABSTRACT	The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.
FILED	Tuesday, July 02, 2019
APPL NO	16/460221
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) Original (OR) Class C07K 14/70507 (20130101) C07K 16/30 (20130101) C07K 16/2803 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101)
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11597773 — CD6 antibody for treatment of T-cell mediated diseases or disorders

US 11597773	Lin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio); The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio); THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Feng Lin (Willoughby, Ohio); David A. Fox (Ann Arbor, Michigan)
ABSTRACT	A method of treating a T-cell mediated disease in a subject by administering to the subject a therapeutically effective amount of an antibody or fragment thereof that specifically binds to CD6 is described. Humanized antibodies useful for the method are also described.
FILED	Wednesday, January 15, 2020
APPL NO	16/743278
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/51 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/515 (20130101) C07K 2319/30 (20130101)
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11597778 — Human monoclonal autoantibodies to ADAMTS13 and uses thereof

US 11597778	Siegel et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Donald L. Siegel (Lansdale, Pennsylvania); Stephen Kacir (Norristown, Pennsylvania); Eric Ostertag (Lexington, Kentucky); X. Long Zheng (Wallingford, Pennsylvania)
ABSTRACT	The present invention relates to compositions and methods of use of anti-ADAMTS13 autoantibodies and fragments thereof. In one aspect, the invention includes a composition comprising an isolated anti-ADAMTS13 autoantibody or fragment thereof. In other aspects, methods are described for generating an in vivo model of thrombotic thrombocytopenic purpura (TTP) comprising introducing at least one anti-ADAMTS13 autoantibody or fragment thereof into a model organism and identifying an anti-autoimmune reagent for treating TTP.
FILED	Wednesday, April 06, 2016
APPL NO	15/564679
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/4886 (20130101) A61K 49/0004 (20130101) A61K 49/0008 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Enzymes C12Y 304/24087 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 2333/96486 (20130101) G01N 2500/04 (20130101) G01N 2500/20 (20130101)
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11597911 — Expansion of populations of T cells by the use of modified serum free media

US 11597911	Varela-Rohena et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Life Technologies Corporation (Carlsbad, California); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Life Technologies Corporation (Carlsbad, California); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Angel M. Varela-Rohena (Williamsville, New York); Melanie B. Andolina (Collins, New York); James L. Riley (Downingtown, Pennsylvania); Andrew Medvec (Philadelphia, Pennsylvania)
ABSTRACT	This invention relates, inter alia, to compositions of low serum or serum free media and methods for the expansion of T cell populations and methods for using such populations of cells. In some aspects, the invention relates to compositions and methods for the selective expansion of T cell subpopulations.
FILED	Monday, February 26, 2018
APPL NO	16/487266
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0031 (20130101) C12N 5/0636 (20130101) Original (OR) Class C12N 5/0637 (20130101) C12N 2500/34 (20130101) C12N 2500/36 (20130101) C12N 2500/99 (20130101) C12N 2501/00 (20130101) C12N 2501/999 (20130101)
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11597913 — Methods for generating hematopoietic stem cells

US 11597913	Shah
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S)	Dhvanit I. Shah (Chestnut Hill, Massachusetts)
ABSTRACT	In some aspects and embodiments, the invention provides methods for making hematopoietic stem cells, including for HSCT. The method comprises providing a cell population comprising hemogenic endothelial (HE) or endothelial cells, and increasing activity or expression of DNA (cytosine-5-)-methyltransferase 3 beta (Dnmt3b) and/or GTPase IMAP Family Member 6 (Gimap6) in the HE and/or endothelial cells under conditions sufficient for stimulating formation of HSCs.
FILED	Tuesday, May 31, 2022
APPL NO	17/828393
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 2501/999 (20130101) C12N 2506/28 (20130101) C12N 2527/00 (20130101)
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11597916 — Nicotine degrading enzyme variants

US 11597916	Kalnik et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA) U.S. Public Health Service (USPHS)
APPLICANT(S)	ANTIDOTE THERAPEUTICS, INC. (Sykesville, Maryland); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	ANTIDOTE THERAPEUTICS, INC. (Bethesda, Maryland); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Matthew W. Kalnik (Bethesda, Maryland); Thomas Thisted (New Market, Maryland); Everett Stone (Austin, Texas); Charles C. Reed (Souderton, Pennsylvania); Max Rodnick-Smith (Austin, Texas)
ABSTRACT	Described are nicotine-degrading enzyme variants that exhibit increased nicotine-degrading activity and/or decreased immunogenicity relative to the wild-type NicA2 and NOX enzymes, compositions comprising the variants, and methods using them.
FILED	Friday, February 02, 2018
APPL NO	16/483380
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0004 (20130101) C12N 9/0006 (20130101) Original (OR) Class
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11597919 — Systems, methods and compositions for sequence manipulation with optimized functional CRISPR-Cas systems

US 11597919	Konermann et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); University of Tokyo (Tokyo, Japan); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S)	THE BROAD INSTITUTE INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); UNIVERSITY OF TOKYO (Tokyo, Japan)
INVENTOR(S)	Silvana Konermann (Zurich, Switzerland); Alexandro Trevino (Stanford, California); Mark Brigham (Somerville, Massachusetts); Fei Ran (Boston, Massachusetts); Patrick Hsu (San Diego, California); Chie-yu Lin (Boston, Massachusetts); Osamu Nureki (Kanagawa, Japan); Hiroshi Nishimasu (Tokyo, Japan); Ryuichiro Ishitani (Tokyo, Japan); Feng Zhang (Cambridge, Massachusetts)
ABSTRACT	The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
FILED	Thursday, October 03, 2019
APPL NO	16/592744
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Enzymes C12Y 301/00 (20130101)
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11597930 — Targeted inhibition using engineered oligonucleotides

US 11597930	Place et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	miRecule, Inc. (Gaithersburg, Maryland)
ASSIGNEE(S)	MIRECULE, INC. (Gaithersburg, Maryland)
INVENTOR(S)	Robert Place (Gaithersburg, Maryland); Anthony Saleh (Gaithersburg, Maryland); Tishan Williams (Gaithersburg, Maryland)
ABSTRACT	Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.
FILED	Friday, March 11, 2022
APPL NO	17/692644
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101)
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11597934 — Methods and compositions for reducing immunosuppression by tumor cells

US 11597934	Wucherpfennig et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	DANA FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
INVENTOR(S)	Kai W. Wucherpfennig (Brookline, Massachusetts); Glenn Dranoff (Sudbury, Massachusetts); Penghui Zhou (Quincy, Massachusetts); Donald Shaffer (Boston, Massachusetts); Nir Hacohen (Brookline, Massachusetts); Harvey I. Cantor (Wellesley, Massachusetts); Diana Alvarez Arias (Midland, Michigan)
ABSTRACT	The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.
FILED	Tuesday, November 24, 2020
APPL NO	17/102787
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0011 (20130101) A61K 39/001195 (20180801) A61K 2039/585 (20130101) A61K 2039/5158 (20130101) Peptides C07K 14/7051 (20130101) C07K 16/32 (20130101) C07K 2317/24 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) C12N 15/113 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/178 (20130101)
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11597949 — Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation

US 11597949	Zhang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S)	Feng Zhang (Cambridge, Massachusetts); Patrick Hsu (Cambridge, Massachusetts); Chie-Yu Lin (Cambridge, Massachusetts); Fei Ran (Cambridge, Massachusetts)
ABSTRACT	The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.
FILED	Thursday, April 09, 2020
APPL NO	16/844548
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/1082 (20130101) C12N 2800/80 (20130101)
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11597964 — Droplet-based method and apparatus for composite single-cell nucleic acid analysis

US 11597964	Regev et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Aviv Regev (Cambridge, Massachusetts); Evan Zane Macosko (Cambridge, Massachusetts); Steven Andrew McCarroll (Cambridge, Massachusetts); Alexander K. Shalek (Cambridge, Massachusetts); Anindita Basu (Cambridge, Massachusetts); Christopher B. Ford (Cambridge, Massachusetts); Hongkun Park (Lexington, Massachusetts); David A. Weitz (Bolton, Massachusetts)
ABSTRACT	The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
FILED	Wednesday, March 08, 2017
APPL NO	15/453405
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1096 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) Original (OR) Class C12Q 1/6809 (20130101) C12Q 1/6834 (20130101) C12Q 1/6834 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 2521/107 (20130101) C12Q 2521/107 (20130101) C12Q 2521/107 (20130101) C12Q 2525/15 (20130101) C12Q 2525/15 (20130101) C12Q 2525/15 (20130101) C12Q 2525/155 (20130101) C12Q 2525/155 (20130101) C12Q 2525/155 (20130101) C12Q 2525/161 (20130101) C12Q 2525/161 (20130101) C12Q 2525/161 (20130101) C12Q 2525/173 (20130101) C12Q 2525/173 (20130101) C12Q 2525/173 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/159 (20130101) C12Q 2563/159 (20130101) C12Q 2563/159 (20130101) C12Q 2563/179 (20130101) C12Q 2565/629 (20130101) C12Q 2565/629 (20130101) C12Q 2565/629 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/06 (20130101)
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11597966 — Non-invasive diagnosis of graft rejection in organ transplant patients

US 11597966	Quake et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) NIH Office of the Director (NIHOD)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Stephen R. Quake (Stanford, California); Thomas M. Snyder (Palo Alto, California); Hannah Valantine (Stanford, California)
ABSTRACT	The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
FILED	Thursday, June 09, 2022
APPL NO	17/836671
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6837 (20130101) C12Q 1/6858 (20130101) C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201)
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11597974 — Transposition of native chromatin for personal epigenomics

US 11597974	Giresi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Paul Giresi (Palo Alto, California); Jason D. Buenrostro (Redwood City, California); Howard Y. Chang (Stanford, California); William J. Greenleaf (Menlo Park, California)
ABSTRACT	Provided herein is a method for analyzing polynucleotides such as genomic DNA. In certain embodiments, the method comprises: (a) treating chromatin isolated from a population of cells with an insertional enzyme complex to produce tagged fragments of genomic DNA; (b) sequencing a portion of the tagged fragments to produce a plurality of sequence reads; and (c) making an epigenetic map of a region of the genome of the cells by mapping information obtained from the sequence reads to the region. A kit for performing the method is also provided.
FILED	Monday, June 06, 2022
APPL NO	17/833686
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2521/301 (20130101) C12Q 2537/164 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 30/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101)
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11597976 — Identification of telomere length as a diagnostic biomarker for heritable cardiomyopathies

US 11597976	Blau et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Helen M. Blau (Menlo Park, California); Chia Yu Alex Chang (Palo Alto, California)
ABSTRACT	Shortened telomeres are diagnostic of genetic predisposition to cardiomyopathies, e.g. those related to defects in structural proteins expressed in cardiomyocytes.
FILED	Wednesday, February 22, 2017
APPL NO	16/078486
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/136 (20130101) C12Q 2600/156 (20130101)
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11597978 — Personalized pain management and anesthesia: preemptive risk identification and therapeutic decision support

US 11597978	Sadhasivam et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR)
APPLICANT(S)	CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio)
ASSIGNEE(S)	CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio)
INVENTOR(S)	Senthilkumar Sadhasivam (Mason, Ohio); Vidya Chidambaran (Cincinnati, Ohio); John McAuliffe (Cincinnati, Ohio); Kejian Zhang (Cincinnati, Ohio); Jaroslaw Meller (Cincinnati, Ohio); Cynthia A. Prows (Cincinnati, Ohio); Tsuyoshi Fukuda (Cincinnati, Ohio)
ABSTRACT	Methods and compositions disclosed herein generally relate to methods of improving clinical and economic outcomes to address adverse effects related to anesthesia, analgesics, opioids, and inadequate pain relief. Embodiments of the invention relate to the association between genes, specific polymorphisms of genes, and non-genetic factors with inadequate pain relief and anesthesia-, analgesic, and/or opioid-related adverse effects. Embodiments of the invention can be used to determine and manage patient risk factors for development of adverse perioperative effects and can allow for personalized anesthesia and pain management for improvement of pain control and reduction of anesthesia-, analgesic-, and opioid-related adverse outcomes. These methods and compositions apply to non-surgical pain management with opioids. Therefore, patients who are genetically predisposed to risk of inadequate pain relief and/or serious side effects from anesthesia, analgesics, and/or opioids can be identified and individualized treatment plans developed for implementation by the clinician to improve clinical and economic outcomes.
FILED	Thursday, April 16, 2020
APPL NO	16/850537
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/172 (20130101)
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11597979 — Methods and compositions for detecting risk of cancer relapse

US 11597979	Van Den Brink et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S)	MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
INVENTOR(S)	Marcel Van Den Brink (New York, New York); Robert Jenq (New York, New York); Jonathan U. Peled (Roosevelt Island, New York)
ABSTRACT	The present invention relates to methods and compositions for reducing the risk of cancer relapse in a subject who has received cancer treatment. It is based, at least in part, on the discovery that a restricted fraction of the gut microbiota, including the bacteria Streptococcus anginosus, Parvimonas micra, Acidaminococcus intestini, Eubacterium limosum, Clostridium glycyrrhizinilyticum, Desulfosporosinus lacus, Eubacterium biforme, Anaerofustis stercorihominis, Pseudoramibacter alactolyticus, Peptococcus niger, Armatimonas rosea, Saccharofermentans acetigenes, Finegoldia magna, Levyella massiliensis, Gallicola barnesae, Murdochiella asaccharolytica, and Eubacterium brachy are associated with a reduced risk of cancer relapse.
FILED	Friday, September 02, 2016
APPL NO	15/756845
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/135 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0031 (20130101) A61K 9/0043 (20130101) A61K 9/0053 (20130101) A61K 35/28 (20130101) A61K 35/74 (20130101) A61K 35/741 (20130101) A61K 38/164 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/205 (20210501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/01 (20210501)
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11598774 — Methods of diagnosis and treatment of Alzheimer's Disease

US 11598774	Zhan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Xinhua Zhan (Vacaville, California); Boryana S. Stamova-Kiossepacheva (Davis, California); Frank R. Sharp (Davis, California)
ABSTRACT	Provided are methods of mitigating, reversing or eliminating in a subject one or more symptoms associated with cognitive impairment associated with amyloid deposits in the brain (e.g., olfactory dysfunction as a risk factor of dementia, mild cognitive impairment, Alzheimer's Disease) by detecting and targeting gram negative bacteria in the brain.
FILED	Tuesday, April 23, 2019
APPL NO	16/392182
ART UNIT	1699 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 33/56916 (20130101) Original (OR) Class G01N 2333/245 (20130101) G01N 2800/2821 (20130101)
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11598778 — Method for diagnosis, prognosis and determination of treatment for cutaneous t-cell lymphoma

US 11598778	Geskin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) National Cancer Institute (NCI) National Center for Research Resources (NCRR)
APPLICANT(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
INVENTOR(S)	Larisa J. Geskin (Riverdale, New York); Brittany Lynn O'Neill Dulmage (Pittsburgh, Pennsylvania); Louis D. Falo, Jr. (Pittsburgh, Pennsylvania)
ABSTRACT	The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX, PLS3, KIR3DL2, and/or GATA3 is associated with CTCL and decreased expression of RUNX3, relative to normal control, is associated with CTCL. One or more of these biomarkers may be used to diagnose CTCL and/or design and monitor treatment.
FILED	Friday, June 18, 2021
APPL NO	17/351950
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/395 (20130101) A61K 31/519 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) A61N 5/062 (20130101) A61N 2005/0661 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) G01N 33/57426 (20130101) Original (OR) Class
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11598782 — Biomarkers and methods for detection of seizures and epilepsy

US 11598782	Wallach et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	EVOGEN, INC. (Overland Park, Kansas)
ASSIGNEE(S)	Cognizance Biomarkers, LLC (Miami, Florida)
INVENTOR(S)	Todd Wallach (Overland Park, Kansas); Peter Crino (Overland Park, Kansas); John Pollard (Overland Park, Kansas); Elizabeth Brand (Overland Park, Kansas); Maura Strauman (Overland Park, Kansas); Christopher Hollenbeak (Overland Park, Kansas); Rich St. Clair (Overland Park, Kansas); Jeffrey Botbyl (Overland Park, Kansas); John Gledhill (Overland Park, Kansas)
ABSTRACT	Epileptic seizures are difficult to diagnose and are often difficult to distinguish from several conditions with similar presentations, and therefore, diagnosis of seizures is often a long, expensive, and unreliable process. This invention provides biomarkers for identifying seizures and epilepsy, assays for measuring and assessing biomarker concentration, predictive models based on biomarkers and computer systems for detecting, assessing and diagnosing phasic and tonic changes associated with seizures and epilepsy in all clinical and healthcare settings. Diagnostic methods, kits and predictive models provided herein provide quantitative and/or qualitative assessment in order to allow patients to proceed immediately to diagnostic and/or treatment protocols, and assess therapeutic treatment effectiveness.
FILED	Thursday, June 04, 2020
APPL NO	16/893266
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/20 (20130101) A61K 31/27 (20130101) A61K 31/53 (20130101) A61K 31/55 (20130101) A61K 31/195 (20130101) A61K 31/513 (20130101) A61K 31/515 (20130101) A61K 31/551 (20130101) A61K 31/4015 (20130101) A61K 31/4166 (20130101) A61K 31/5513 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/2857 (20130101)
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11598783 — In vitro detection of prions

US 11598783	Mathiason et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Candace K. Mathiason (Windsor, Colorado); Edward A. Hoover (Fort Collins, Colorado)
ASSIGNEE(S)	Colorado State University Research Foundation (Fort Collins, Colorado)
INVENTOR(S)	Candace K. Mathiason (Windsor, Colorado); Edward A. Hoover (Fort Collins, Colorado)
ABSTRACT	A method for the pre-amplification sample processing of a prion or other amyloid converting protein in a sample. A key feature of the assay is its ability to amplify and thus detect small quantities of the abnormally folded ‘seed’ forms of misfolded proteins. The assay also opens up the ability to quantify the amount of “seed” present. The methods facilitate the early detection of diseases associated with misfolded proteins, as well as assessment of therapies against these diseases. The method can detect amyloid seeding activity (prions) in blood samples, including the buffy coat cells harvested from pre-clinical and clinical subjects. These findings further enhance the ability to assess the longitudinal course of prion disease and the role hematogenous prions play in pathogenesis. We demonstrate the ability to detect prions in as few as 5×10⁵buffy coat cells by lipase-iron oxide bead-RT-QuIC performed at 42° C. (LIQ42) in 79% of CWD-biopsy positive WTD, which increased to 100% when LIQ was performed at 55° C. (LIQ55). RT-QuIC assessment of PMCA (PQ) round 5 product revealed hematogenous prions in 92% of the WTD.
FILED	Friday, October 23, 2020
APPL NO	17/078678
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2333/4709 (20130101) G01N 2800/2828 (20130101)
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11599994 — System and methods for clear optimally matched panoramic channel technique for deep brain photonic interface

US 11599994	Cui
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Meng Cui (West Lafayette, Indiana)
ABSTRACT	An optical tissue imaging system includes a probe for insertion into a transparent cylindrical capillary. The capillary includes an internal cylindrical channel that extends along a central axis. The capillary is inserted into tissue of a subject, and the probe may rotate and translate within the capillary. The probe may include a mirror configured to reflect light to the tissue outside of the cylindrical capillary.
FILED	Saturday, March 28, 2020
APPL NO	16/833550
ART UNIT	2872 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 3/0087 (20130101) G02B 5/04 (20130101) G02B 13/0095 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/30016 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 43/28 (20130101)
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11599998 — Machine learning systems and methods for assessment, healing prediction, and treatment of wounds

US 11599998	Fan et al.
FUNDED BY	Department of Defense (DOD) Defense Health Agency (DHA) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA)
APPLICANT(S)	SPECTRAL MD, INC. (Dallas, Texas)
ASSIGNEE(S)	SPECTRAL MD, INC. (Dallas, Texas)
INVENTOR(S)	Wensheng Fan (Plano, Texas); John Michael DiMaio (Dallas, Texas); Jeffrey E. Thatcher (Irving, Texas); Peiran Quan (Dallas, Texas); Faliu Yi (Allen, Texas); Kevin Plant (Dallas, Texas); Ronald Baxter (Grand Prairie, Texas); Brian McCall (Dallas, Texas); Zhicun Gao (Plano, Texas); Jason Dwight (Dallas, Texas)
ABSTRACT	Machine learning systems and methods are disclosed for prediction of wound healing, such as for diabetic foot ulcers or other wounds, and for assessment implementations such as segmentation of images into wound regions and non-wound regions. Systems for assessing or predicting wound healing can include a light detection element configured to collect light of at least a first wavelength reflected from a tissue region including a wound, and one or more processors configured to generate an image based on a signal from the light detection element having pixels depicting the tissue region, determine reflectance intensity values for at least a subset of the pixels, determine one or more quantitative features of the subset of the plurality of pixels based on the reflectance intensity values, and generate a predicted or assessed healing parameter associated with the wound over a predetermined time interval.
FILED	Friday, September 04, 2020
APPL NO	17/013336
ART UNIT	2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/445 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/30088 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/30 (20180101)
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11600361 — Nucleic acid sequence assembly

US 11600361	Putnam et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	Dovetail Genomics, LLC (Scotts Valley, California)
ASSIGNEE(S)	Dovetail Genomics, LLC (Scotts Valley, California)
INVENTOR(S)	Nicholas H. Putnam (Waltham, Massachusetts); Jonathan C. Stites (Santa Cruz, California); Brandon J. Rice (Santa Cruz, California)
ABSTRACT	Disclosed herein are compositions, systems and methods related to sequence assembly, such as nucleic acid sequence assembly of single reads and contigs into larger contigs and scaffolds through the use of read pair sequence information, such as read pair information indicative of nucleic acid sequence phase or physical linkage.
FILED	Wednesday, February 13, 2019
APPL NO	16/275037
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 30/20 (20190201) Original (OR) Class
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11600373 — Biodosimetry panels and methods

US 11600373	Blakely et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Health and Human Services (HHS)
APPLICANT(S)	MESO SCALE TECHNOLOGIES, LLC (Rockville, Maryland); THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland)
ASSIGNEE(S)	MESO SCALE TECHNOLOGIES, LLC. (Rockville, Maryland); THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland)
INVENTOR(S)	William F. Blakely (Silver Spring, Maryland); Eli N. Glezer (Del Mar, California); John Kenten (Boyds, Maryland); Sudeep Kumar (Gaithersburg, Maryland); Anu Mathew (North Potomac, Maryland); Natalia I. Ossetrova (Silver Spring, Maryland); George Sigal (Rockville, Maryland)
ABSTRACT	The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
FILED	Thursday, August 29, 2019
APPL NO	16/555271
ART UNIT	2857 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3273 (20130101) G01N 33/6893 (20130101) G01N 35/00 (20130101) G01N 2333/70535 (20130101) G01N 2333/70578 (20130101) G01N 2800/40 (20130101) G01N 2800/60 (20130101) Measurement of Nuclear or X-radiation G01T 1/00 (20130101) G01T 1/02 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) Original (OR) Class
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11600481 — Devices and processes for mass spectrometry utilizing vibrating sharp-edge spray ionization

US 11600481	Li et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	West Virginia University (Morgantown, West Virginia)
ASSIGNEE(S)	West Virginia University (Morgantown, West Virginia)
INVENTOR(S)	Peng Li (Morgantown, West Virginia); Xiaojun Li (Morgantown, West Virginia); Stephen J. Valentine (Morgantown, West Virginia); Lisa Holland (Morgantown, West Virginia)
ABSTRACT	In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to a vibrating sharp edge spray ionization (VSSI) method suitable for coupling with a mass spectrometer, a VSSI method modified with a capillary suitable for use with continuous-flow separation methods such as liquid chromatography, and a VSSI method suitable for coupling with a capillary electrophoresis (CE) device in order to introduce the CE sample flow into a mass spectrometer. Also disclosed herein are devices for carrying out these methods and methods of making the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
FILED	Monday, July 13, 2020
APPL NO	16/927936
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/16 (20130101) Original (OR) Class H01J 49/0031 (20130101)
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Department of Defense (DOD)

11596194 — Helmet face shield

US 11596194	Snow et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Keyport, Washington)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (Keyport, Washington)
INVENTOR(S)	Jacob Snow (Bremerton, Washington); Jacob Yates (Poulsbo, Washington); Nathan Schuyler (Silverdale, Washington)
ABSTRACT	A face shield for use with protective headgear can be shipped flat and easily assembled from a kit of parts without the use of tools or adhesives. The face shield protects against disease, aerosols and splatter that may contain pathogens; may include a curved lower perimeter to facilitate head movements, and can be taken on and off easily.
FILED	Tuesday, July 19, 2022
APPL NO	17/868745
ART UNIT	3732 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Hats; Head Coverings A42B 3/18 (20130101) Original (OR) Class
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11596329 — Soft, wearable microfluidic systems capable of capture, storage and sensing of biofluids

US 11596329	Rogers et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois); Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois); Northwestern University (Evanston, Illinois)
INVENTOR(S)	John A. Rogers (Wilmette, Illinois); Jungil Choi (Chicago, Illinois); Sungbong Kim (Champaign, Illinois)
ABSTRACT	The invention provides systems for handling biofluids including the transport, capture, collection, storage, sensing, and/or evaluation of biofluids released by tissue. Systems of some aspects provide a versatile platform for characterization of a broad range of physical and/or chemical biofluid attributes in real time and over clinically relevant timeframes. Systems of some aspects provide for collection and/or analysis of biofluids from conformal, watertight tissue interfaces over time intervals allowing for quantitative temporal and/or volumetric characterization of biofluid release, such as release rates and release volumes.
FILED	Tuesday, May 12, 2020
APPL NO	16/872522
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/6833 (20130101) A61B 5/14517 (20130101) Original (OR) Class A61B 2560/0214 (20130101) A61B 2560/0462 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2300/0803 (20130101) B01L 2300/0864 (20130101) B01L 2300/0883 (20130101) B01L 2400/0406 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101)
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11596346 — Signal processing for decoding intended movements from electromyographic signals

US 11596346	Wendelken et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON)
APPLICANT(S)	University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Suzanne Wendelken (Salt Lake City, Utah); Tyler Davis (Salt Lake City, Utah); David Page (Salt Lake City, Utah); David Kluger (Salt Lake City, Utah); David Warren (Salt Lake City, Utah); Gregory Clark (Salt Lake City, Utah); Christopher Duncan (Salt Lake City, Utah); Jacob Nieveen (Salt Lake City, Utah)
ABSTRACT	A technology is described for determining an intended movement from neuromuscular signals. An example method (800) includes receiving electromyography (EMG) data corresponding to single-ended channels of an electrode array (810), where EMG signals are detected by electrodes comprising the single-ended channels of the electrode array and the EMG signals are converted to the EMG data. Determining differential channel pairs for the single-ended channels of the electrode array (820) and extracting feature data from the EMG data of the differential channel pairs (830). Thereafter a feature data set is selected from the feature data of the differential channel pairs (840) and the feature data set is input to a decode model configured to correlate the feature data set to an intended movement (850). Decode output is received from the decode model indicating the intended movement (860) and the decode output is provided to a device (870).
FILED	Tuesday, August 01, 2017
APPL NO	16/322855
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/389 (20210101) Original (OR) Class A61B 2562/046 (20130101) A61B 2562/0252 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 7/00 (20130101)
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11596411 — Aortic flow meter and pump for partial-aortic occlusion

US 11596411	Johnson et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California); Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Michael Austin Johnson (Sacramento, California); Timothy K. Williams (Travis AFB, California); Lucas Paul Neff (Decatur, Georgia)
ABSTRACT	Systems and methods for partial aortic occlusion are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient, and a catheter controller unit that causes the device to expand and contract to restrict blood flow through the aorta. The system also may include sensors for measuring blood pressure distal and proximal to the expandable device. The system further may include non-transitory computer readable media having instructions stored thereon, wherein the instructions, when executed by a processor coupled to the sensors, cause the processor to estimate aortic blood flow based on the measured blood pressures and corresponding waveforms, compare the estimated aortic blood flow with a target aortic blood flow range, generate an alert if the estimated aortic blood flow falls outside the target aortic blood flow range, and cause the catheter controller unit to adjust expansion and contraction of the expandable device to adjust an amount of blood flow through the aorta if the estimated aortic blood flow falls outside the target aortic blood flow range.
FILED	Friday, October 18, 2019
APPL NO	16/657588
ART UNIT	3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/12036 (20130101) Original (OR) Class A61B 17/12109 (20130101) A61B 17/12136 (20130101) A61B 2017/00022 (20130101) A61B 2017/00119 (20130101) A61B 2017/00199 (20130101) A61B 2017/00221 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/10182 (20131105) A61M 2205/18 (20130101) A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/3334 (20130101) A61M 2210/127 (20130101) A61M 2230/04 (20130101) A61M 2230/30 (20130101) A61M 2230/42 (20130101) A61M 2230/50 (20130101)
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11596651 — Therapeutic metal complexes and ligands and methods of making and using the same

US 11596651	Beckman et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	Oregon State University (Corvallis, Oregon)
ASSIGNEE(S)	Oregon State University (Corvallis, Oregon)
INVENTOR(S)	Joseph Beckman (Corvallis, Oregon); James Hurst (Beaverton, Oregon); John Sirois (Corvallis, Oregon); Chris Beaudry (Corvallis, Oregon)
ABSTRACT	Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments.
FILED	Wednesday, February 26, 2020
APPL NO	16/802410
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/4545 (20130101) A61K 33/34 (20130101) Original (OR) Class A61K 45/06 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101)
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11596797 — Removal of stimulation artifact in multi-channel neural recordings

US 11596797	Sabes et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Philip Sabes (San Francisco, California); Joseph O'Doherty (San Francisco, California)
ABSTRACT	Stimulation of nervous system components by electrodes can be used in many applications, including in the operation of brain-machine interfaces, bidirectional neural interfaces, and neuroprosthetics. The optimal operation of such systems requires a means of accurately measuring neural responses to such stimulations. However, currently the measurement of neural responses is difficult due to heavy stimulation artifacts arising from stimulatory pulses. The invention encompasses novel methods of estimating stimulation artifacts in measurements attained by recording electrodes and the effective removal of these artifacts. This provides improved neural recording systems and enables the deployment of closed-loop neural stimulation systems.
FILED	Wednesday, March 14, 2018
APPL NO	16/494246
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/24 (20210101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/0534 (20130101) A61N 1/36053 (20130101) A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36096 (20130101) A61N 1/36135 (20130101) Original (OR) Class
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11597013 — Low thermal stress engineered metal structures

US 11597013	Sherman et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Powdermet, Inc. (Euclid, Ohio)
ASSIGNEE(S)	POWDERMET, INC. (Euclid, Ohio)
INVENTOR(S)	Andrew Sherman (Mentor, Ohio); Brian Werry (Euclid, Ohio)
ABSTRACT	A structured multi-phase composite which include a metal phase, and a low stiffness, high thermal conductivity phase or encapsulated phase change material, that are arranged to create a composite having high thermal conductivity, having reduced/controlled stiffness, and a low CTE to reduce thermal stresses in the composite when exposed to cyclic thermal loads. The structured multi-phase composite is useful for use in structures such as, but not limited to, high speed engine ducts, exhaust-impinged structures, heat exchangers, electrical boxes, heat sinks, and heat spreaders.
FILED	Tuesday, June 23, 2020
APPL NO	16/909126
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 31/00 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/16 (20130101) B22F 3/1112 (20130101) Original (OR) Class B22F 2003/1106 (20130101) B22F 2998/10 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/16 (20130101) B32B 5/18 (20130101) B32B 5/20 (20130101) Alloys C22C 1/1084 (20130101) C22C 29/14 (20130101) C22C 32/0031 (20130101) C22C 32/0036 (20130101) C22C 32/0078 (20130101) C22C 49/00 (20130101) C22C 49/06 (20130101) C22C 49/11 (20130101)
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11597016 — Efficient bulk unfused powder removal system and method

US 11597016	Hoy et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Non-Profit Organization (NPO) National Center for Manufacturing Sciences Inc. (NCMS)
APPLICANT(S)	3D Systems, Inc. (Rock Hill, South Carolina)
ASSIGNEE(S)	3D SYSTEMS, INC. (Rock Hill, South Carolina)
INVENTOR(S)	Ahren Michael Hoy (Charlotte, North Carolina); Turner Ashby Cathey (Rock Hill, South Carolina); Alexander J Geyling (Fort Mill, South Carolina)
ABSTRACT	An additive manufacturing system for producing a three-dimensional article includes a print engine, a post-fabrication powder removal apparatus, a transport mechanism, and a controller. The post fabrication removal apparatus includes a rotary frame defining an internal receptacle cavity, a plurality of clamps coupled to a corresponding plurality of actuators, a clamping plate coupled to a lift apparatus, and an agitation device mounted to the clamping plate. The controller is configured to perform the following steps: (1) Operate the transport mechanism to transport the build box to the internal receptacle cavity. (2) Operate the plurality of actuators to engage the build box with the plurality of clamps to secure the build box to the rotary frame. (3) Operate the rotary frame to rotate the build box until unfused powder begins to exit the build box. (4) Operate the agitation device to facilitate pouring of the unfused powder from the build box.
FILED	Monday, August 16, 2021
APPL NO	17/402811
ART UNIT	2853 — Printing/Measuring and Testing
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/68 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101)
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11597500 — Method of making a variable camber control surface

US 11597500	Dooley
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Newport, Rhode Island)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (, None)
INVENTOR(S)	Richard E Dooley (Portsmouth, Rhode Island)
ABSTRACT	A variable camber wing for mounting to a vehicle chassis has an actuator shaft and a static pin extending from the chassis. The wing's nose segment defines a proximal edge and a distal edge and has a channel therethrough between the proximal and distal edges, an arcuate aperture therethrough aft of the channel, and a second aperture therethrough aft of the arcuate aperture. The wing has a first linkage defining a clevis on a proximal end and hingeably connected to the nose segment. The clevis can rotatably engage with the static pin extending through the arcuate aperture. A second linkage defines a second clevis on a proximal end and a distal edge. The second linkage is configured to hingeably connect to the first linkage.
FILED	Friday, August 05, 2022
APPL NO	17/881680
ART UNIT	3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 3/10 (20130101) B64C 3/48 (20130101) Original (OR) Class B64C 3/187 (20130101) B64C 13/30 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/10 (20170101)
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11597516 — Airborne multi-rotor delivery system

US 11597516	Klinkmueller et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	U.S. Government as Represented by the Secretary of the Army (Dover, New Jersey)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Kurt Klinkmueller (Newport News, Virginia); Anthony Wieck (Columbus, Georgia); Andrew Valentine (Potomac, Maryland); Joshua Holt (Copperas Cove, Texas); James Bluman (West Point, New York); Andrew Kopeikin (Norwood, Massachusetts); Ekaterina Kuhlwein (Shrewsbury, Massachusetts); Abdul Halim Abdul Rahim (Picatinny Arsenal, New Jersey); Ronald Tobin (Fairbanks, Arkansas); Nena Riccoboni (Picatinny Arsenal, New Jersey); Seth Jackson (Picatinny Arsenal, New Jersey)
ABSTRACT	An airborne delivery system employs unmanned aerial vehicles (UAVs) released from an airborne platform, such as a Joint Precision Airdrop System (JPAD), to more accurately deliver supplies. The airborne delivery system is configured to be mounted on a JPAD, or similar airborne platform. As with a conventional JPAD, the JPAD is then released from an airborne vehicle. After a certain amount of flight time, one or more UAVs are released mid-flight from the airborne delivery system.
FILED	Monday, April 27, 2020
APPL NO	16/859372
ART UNIT	3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/027 (20130101) B64C 2201/082 (20130101) B64C 2201/128 (20130101) B64C 2201/141 (20130101) B64C 2201/206 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 1/12 (20130101) Original (OR) Class
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11597769 — Nanobody based imaging and targeting of ECM in disease and development

US 11597769	Hynes et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts)
INVENTOR(S)	Richard O. Hynes (Winchester, Massachusetts); Noor Jailkhani (Cambridge, Massachusetts); Hidde L. Ploegh (Boston, Massachusetts); Yushu Joy Xie (Brookline, Massachusetts)
ABSTRACT	Methods for developing disease-related nanobodies and related products and kits are provided. The disease-specific proteins are extracellular matrix (ECM) proteins, domains or epitopes that are associated with various aspects of disease and are not present, or are present in very low quantities, in non-diseased individuals. Highly effective nanobodies capable of specifically binding to these ECM protein epitopes useful in in vivo imaging assays, the detection, diagnosis and treatment of diseases as well as monitoring therapeutic progress in a patient with a disease are provided herein.
FILED	Friday, January 25, 2019
APPL NO	16/258457
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/6809 (20170801) A61K 47/6813 (20170801) A61K 47/6849 (20170801) A61K 47/6851 (20170801) A61K 49/0058 (20130101) A61K 49/085 (20130101) A61K 51/1027 (20130101) A61K 51/1045 (20130101) A61K 51/1051 (20130101) A61K 51/1057 (20130101) A61K 51/1093 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 14/78 (20130101) C07K 16/18 (20130101) C07K 16/2842 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/569 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101)
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11597798 — Porphene, a heterocyclic analog of graphene, methods of making and using the same

US 11597798	Michl et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
ASSIGNEE(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S)	Josef Michl (Boulder, Colorado); Thomas Frank Magnera (Boulder, Colorado)
ABSTRACT	Methods of forming a porphene polymeric material are provided. The resulting material can be a porphene or a metalloporphene polymeric material. The structure of the polymer can be selected based on a material provided in the monomer material. Methods of using the polymeric material are also provided.
FILED	Friday, December 04, 2020
APPL NO	17/112865
ART UNIT	1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/122 (20130101) Original (OR) Class C08G 85/004 (20130101) C08G 2261/40 (20130101) C08G 2261/374 (20130101) C08G 2261/376 (20130101) C08G 2261/3241 (20130101)
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11597843 — Melanin extraction from black knot fungus

US 11597843	Dhinojwaqla et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	Ali Dhinojwaqla (Akron, Ohio); K Zin Htut (Yangon, Myanmar); Saranshu Singla (Sangrur, India); Runyao Zhu (Changchun, China PRC); Christopher Maurer (Cleveland, Ohio)
ASSIGNEE(S)	The University of Akron (Akron, Ohio)
INVENTOR(S)	Ali Dhinojwaqla (Akron, Ohio); K Zin Htut (Yangon, Myanmar); Saranshu Singla (Sangrur, India); Runyao Zhu (Changchun, China PRC); Christopher Maurer (Cleveland, Ohio)
ABSTRACT	In various embodiments, the present invention is directed to a melanin composition extracted from black knot fungus (Apiosporina morbosa) using an acid-base extraction technique. In one or more embodiments, the melanin composition is extracted from the black outer layer of a black knot fungus by obtaining a powder including a black outer part of one or more black knot fungus, adding a quantity of an aqueous solution comprising one or more base, heating the mixture to solubilize a melanin in the aqueous solution to form a black alkaline supernatant containing said melanin, adding one or more acids to said black alkaline supernatant until the melanin precipitates out of said black alkaline supernatant, said melanin precipitate further comprising proteins, carbohydrates, and lipids; collecting the melanin precipitate and adding one or more acids to hydrolyze some or all of said proteins, carbohydrates, and lipids and produce the melanin composition.
FILED	Monday, December 28, 2020
APPL NO	17/135162
ART UNIT	1761 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 61/00 (20130101) Original (OR) Class C09B 69/00 (20130101)
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11598388 — Adaptive energy absorber for structural isolation and injury mitigation

US 11598388	Kwiatkowski et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	PRATT and MILLER ENGINEERING AND FABRICATION, INC. (New Hudson, Michigan)
ASSIGNEE(S)	PRATT and MILLER ENGINEERING AND FABRICATION, LLC (New Hudson, Michigan)
INVENTOR(S)	Kevin Rudolph Kwiatkowski (Ann Arbor, Michigan); Christopher James Watson (Ferndale, Michigan); Andrew Nathan Suchezky (South Lyon, Michigan)
ABSTRACT	An energy absorbing strut having, a first end coupled with an inner cylinder, and a second end connected with a hollow rod extending within the inner cylinder. A piston is carried by the rod having an outer surface sealing against an inside diameter of the inner cylinder and forming a compression chamber and a rebound chamber bounded by the piston, the rod having an internal passageway communicating between the compression chamber and the rebound chamber. An inertial mass carried by the rod movable axially on the rod between a closed position against and annular rod passageway and an open position opening the rod passageway and allowing the flow of a hydraulic fluid between the compression chamber and the rebound chamber. A spring acts on the inertial mass biasing the inertial mass toward the closed position. The energy absorbing strut may be used in a blast mitigation system for a military vehicle or other applications for providing shock isolation between two structures.
FILED	Friday, September 06, 2019
APPL NO	16/562653
ART UNIT	3657 — Material and Article Handling
CURRENT CPC	Motor Vehicles; Trailers B62D 24/04 (20130101) B62D 25/2009 (20130101) B62D 27/04 (20130101) Ships or Other Waterborne Vessels; Equipment for Shipping B63B 59/00 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 7/00 (20130101) Springs; Shock-absorbers; Means for Damping Vibration F16F 9/34 (20130101) F16F 9/062 (20130101) F16F 9/065 (20130101) F16F 9/182 (20130101) F16F 9/185 (20130101) F16F 9/504 (20130101) Original (OR) Class F16F 13/007 (20130101) F16F 2222/12 (20130101) F16F 2228/066 (20130101) F16F 2230/16 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 11/00 (20130101)
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11598609 — Wide-angle seeker

US 11598609	Gutin
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Applied Science Innovations, Inc. (Troy, New York)
ASSIGNEE(S)
INVENTOR(S)	Mikhail Gutin (Wynantskill, New York)
ABSTRACT	Seeker optics and a related method comprising: an objective for collecting and transmitting light from a target; at least one scattering surface; and a photo detector; wherein: the light transmitted from the objective at small off-boresight target angles propagates to and impinges upon the photo detector without impinging upon the scattering surface; the light transmitted from the objective at large off-boresight target angles propagates to, impinges upon and scatters upon the scattering surface; and the light scattered by the scattering surface propagates to and impinges upon the photo detector; whereby: the target may be detected and tracked at both small and large off-boresight angles, in a wide field of regard.
FILED	Thursday, March 12, 2015
APPL NO	14/656293
ART UNIT	3619 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Weapon Sights; Aiming F41G 7/226 (20130101) Original (OR) Class F41G 7/2293 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/06 (20130101) G01S 17/66 (20130101) G01S 17/88 (20130101)
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11598613 — Aluminum vehicle hull structure and fabrication method

US 11598613	Brown et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Science Applications International Corporation (Reston, Virginia)
ASSIGNEE(S)	Science Applications International Corporation (Reston, Virginia)
INVENTOR(S)	Peter Brown (Summerville, South Carolina); George S. Chryssomallis (Excelsior, Minnesota); Eric Smay (Mount Pleasant, South Carolina)
ABSTRACT	Aluminum structures, such as tactical vehicle hulls, include plural aluminum components formed from a first alloy composition and joined by one or more welded seam(s). The welded seam(s) may be formed by friction stir welding and/or gas metal arc welding using welding wire made from the first alloy composition. In this manner, all component parts are made from the same alloy composition, providing a more homogeneous structure. The welded component parts then may be placed in a heat treatment furnace to temper the structure. Because essentially all of the aluminum structure before heat treating—the welded seam(s) and the individual component parts—is formed of the same starting material and these parts/seam(s) are simultaneously and evenly heat treated, the resultant hardened, heat-treated part (e.g., a vehicle hull) has a more homogeneous hardened/heat treated structure in the individual parts and across the welded seam(s).
FILED	Friday, December 06, 2019
APPL NO	16/706116
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/04 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 7/044 (20130101) Original (OR) Class
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11598621 — Munitions and methods for operating same

US 11598621	Stowe et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Research Laboratory (AFRL) Air Force Research Laboratory Munitions Directorate (AFRL/RW)
APPLICANT(S)	Corvid Technologies LLC (Mooresville, North Carolina)
ASSIGNEE(S)	Corvid Technologies LLC (Mooresville, North Carolina)
INVENTOR(S)	David Thomas Stowe (Mooresville, North Carolina); Andrew John Auvil (Cornelius, North Carolina)
ABSTRACT	A munition includes a warhead having a warhead axis and axially opposed first and second warhead ends. The warhead includes: a tubular shock attenuation barrier including an axially extending passage extending from a first barrier end proximate the first warhead end to a second barrier end proximate the second warhead end; an explosive core charge disposed in the passage; an explosive main charge surrounding the shock attenuation barrier; projectiles surrounding the main charge; a core charge detonator; and a main charge detonator. The warhead is configured to be activated in each of a first projection mode and an alternative second projection mode. When the warhead is activated in the first projection mode, the main charge detonator detonates the main charge to thereby forcibly project the projectiles from the warhead with a first set of projection velocities and velocity profile. When the warhead is activated in the second projection mode, the core charge detonator detonates the core charge proximate the first barrier end such that a core charge detonation wave propagates through the passage to the second barrier end and, at the second barrier end, the core charge detonation wave detonates the main charge to thereby forcibly project the projectiles from the warhead with a second set of projection velocities and velocity profile. The second set of projectile velocities and velocity profile is different from the first set of projectile velocities and velocity profile.
FILED	Tuesday, April 26, 2022
APPL NO	17/729406
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/28 (20130101) F42B 12/60 (20130101) F42B 12/207 (20130101) Blasting F42D 5/045 (20130101) Original (OR) Class
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11598707 — Medical analyzer and coagulation profiler

US 11598707	Joseph et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	iFirst Medical Technologies, Inc. (Honolulu, Hawaii)
ASSIGNEE(S)	iFirst Medical Technologies, Inc. (Honolulu, Hawaii)
INVENTOR(S)	Luke B. Joseph (Honolulu, Hawaii); Thomas A. Hasling (Honolulu, Hawaii)
ABSTRACT	A medical analyzer and coagulation profiler performs various interrogations on specimens. A motor with reduction gearing moves and a video camera observes the samples, the cartridges or parts thereof. Changes in images are compared and recorded with a central processor that controls a display. Power supply, temperature controller, motor and gearing are mounted in a box which attaches to a smartphone. The smartphone provides the video camera, illumination and central processor that control the movement, temperature and display. The device makes testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and controls a number of parallel or serial devices operating simultaneously or sequentially. A cartridge insertion actuates a circular motion to generate a blood profile based on changes. Change is analyzed with a video camera and processor such as in a smartphone and is plotted to show an amplitude and time. A smartphone provides a specific movement pattern.
FILED	Monday, August 10, 2020
APPL NO	16/989594
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/14 (20130101) Original (OR) Class G01N 2011/147 (20130101)
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11598769 — Oligomerized protein-polymer conjugates

US 11598769	Olsen et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Bradley David Olsen (Arlington, Massachusetts); Hadley Sikes Johnson (Arlington, Massachusetts); Eric Alexander Miller (Cambridge, Massachusetts); Justin Paloni (Cambridge, Massachusetts)
ABSTRACT	The present disclosure relates to protein-polymer conjugates comprising an engineered binding oligomer protein and a polymer for detection of a ligand of interest, methods, compositions and kits thereof.
FILED	Friday, July 26, 2019
APPL NO	16/523209
ART UNIT	1678 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54353 (20130101) Original (OR) Class G01N 33/54366 (20130101)
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11598841 — System and method for distributed dual-function radar-communication

US 11598841	Ahmed et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania); Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	Temple University Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania); Governemnt of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Ammar Ahmed (Philadelphia, Pennsylvania); Yimin Daniel Zhang (Berwyn, Pennsylvania); Braham Himed (Beavercreek, Ohio)
ABSTRACT	A system for distributed dual-function radar-communication comprises a plurality of dual-function radar transmitters positioned within a region of interest, each configured to transmit at least one radar waveform, with each transmitter for having a minimum transmit power, a maximum transmit power, and a working transmit power, a plurality of radar receivers positioned within the region of interest, each configured to receive the radar waveforms, at least one controller communicatively connected to at least one connected transmitter of the plurality of dual-function radar transmitters, configured to calculate a vector of transmit power values for the plurality of dual-function radar transmitters. A method of transmitting a radar waveform is also disclosed.
FILED	Tuesday, April 21, 2020
APPL NO	16/854251
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/006 (20130101) Original (OR) Class G01S 13/003 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11598866 — Single-frequency dynamic metasurface microwave imaging systems and methods of use

US 11598866	Sleasman et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Timothy Sleasman (Takoma Park, Maryland); Laura Pulido Mancera (Durham, North Carolina); Jonah Gollub (San Diego, California); Michael Boyarsky (Durham, North Carolina); Thomas Fromenteze (Durham, North Carolina); Seyedmohammadreza Faghih Imani (Durham, North Carolina); David R. Smith (Durham, North Carolina)
ABSTRACT	A single frequency, or very narrow frequency band, microwave imaging system is described herein. A microwave imaging system can include an array transmitter; an array receiver; and a computing device that receives signals detected from the array receiver, transforms the signals received by the array receiver into independent spatial measurements, constructs an image using the independent spatial measurements, and outputs a reconstructed image. The array transmitter and the array receiver may each have a plurality of independently controllable metasurface resonant elements.
FILED	Monday, June 10, 2019
APPL NO	16/436037
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/03 (20130101) G01S 7/023 (20130101) G01S 7/032 (20130101) G01S 7/352 (20130101) G01S 7/356 (20210501) G01S 13/34 (20130101) G01S 13/36 (20130101) G01S 13/42 (20130101) Original (OR) Class G01S 13/89 (20130101) G01S 13/888 (20130101) Antennas, i.e Radio Aerials H01Q 3/26 (20130101) H01Q 3/2611 (20130101) H01Q 21/0018 (20130101)
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11598868 — Microwave single pixel imager (MSPI)

US 11598868	Bobak et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Research Laboratory (NRL)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Justin P. Bobak (Silver Spring, Maryland); Hatim F. Alqadah (Ashburn, Virginia); Scott M. Rudolph (Washington, District of Columbia); Michael W. Nurnberger (Springfield, Virginia)
ABSTRACT	A microwave single pixel imager apparatus and method of using same. Sampling a targeted scene includes the following. A plurality of modulated antenna patterns is generated using a reflectarray. A plurality of antenna temperatures respectively corresponding to the plurality of modulated antenna patterns is measured. A retrieved scene corresponding to the sampled targeted scene is generated. Generating a retrieved scene corresponding to the sampled targeted scene includes the following. The plurality of modulated antenna patterns and the corresponding plurality of antenna temperatures are fed into a compressive sensing imaging algorithm.
FILED	Thursday, June 25, 2020
APPL NO	16/911417
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/03 (20130101) G01S 13/9021 (20190501) Original (OR) Class Antennas, i.e Radio Aerials H01Q 15/148 (20130101)
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11598878 — Vision-cued random-access lidar system and method for localization and navigation

US 11598878	Mahajan et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Modular Optical Aperture Building Blocks (MOABB)
APPLICANT(S)	Teledyne Scientific and Imaging, LLC (Thousand Oaks, California)
ASSIGNEE(S)	TELEDYNE SCIENTIFIC and IMAGING, LLC (Thousand Oaks, California)
INVENTOR(S)	Milind Mahajan (Thousand Oaks, California); Weiya Zhang (Thousand Oaks, California); Mark Anderson (Chapel Hill, North Carolina); Mario Aguilar-Simon (Chapel Hill, North Carolina); Brian Gregory (Newbury Park, California)
ABSTRACT	A vision-cued random-access LIDAR system and method which determines the location and/or navigation path of a moving platform. A vision system on a moving platform identifies a region of interest. The system classifies objects within the region of interest, and directs random-access LIDAR to ping one or more of the classified objects. The platform is located in three dimensions using data from the vision system and LIDAR. The steps of classifying, directing, and locating are preferably performed continuously while the platform is moving and/or the vision system's field-of-view (FOV) is changing. Objects are preferably classified using at least one smart-vision algorithm, such as a machine-learning algorithm.
FILED	Tuesday, April 07, 2020
APPL NO	16/842697
ART UNIT	3661 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/095 (20130101) B60W 2420/52 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4817 (20130101) G01S 17/58 (20130101) G01S 17/89 (20130101) G01S 17/931 (20200101) Original (OR) Class G01S 19/01 (20130101)
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11598981 — Analyzing microtextured regions of optically anisotropic materials

US 11598981	Satko et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	MRL MATERIALS RESOURCES LLC (Beavercreek, Ohio)
ASSIGNEE(S)	MRL Materials Resources LLC (Beavercreek, Ohio)
INVENTOR(S)	Daniel P. Satko (Centerville, Ohio); Ayman A. Salem (Beavercreek, Ohio)
ABSTRACT	Images of samples that are illuminated with polarized light are captured. Azimuth and inclination data are extracted from the captured images. The azimuth and inclination data are used to quantify MTRs.
FILED	Tuesday, June 04, 2019
APPL NO	16/431161
ART UNIT	2877 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/116 (20130101) Original (OR) Class
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11599006 — Generation of nested frequency combs in a topological source

US 11599006	Mittal et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Air Force Research Laboratory (AFRL) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)	UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland)
INVENTOR(S)	Sunil Mittal (Rockville, Maryland); Mohammad Hafezi (Washington, District of Columbia)
ABSTRACT	Examples of the present disclosure include the use of a topological system including an array of coupled ring resonators that exhibits topological edge states to generate frequency combs and temporal dissipative Kerr solitons. The topological edge states constitute a travelling-wave super-ring resonator causing generation of at least coherent nested optical frequency combs, and self-formation of nested temporal solitons that are robust against defects in the array at a mode efficiency exceeding 50%.
FILED	Monday, November 01, 2021
APPL NO	17/515757
ART UNIT	2874 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3513 (20130101) Original (OR) Class G02F 1/3536 (20130101) G02F 2203/15 (20130101) G02F 2203/17 (20130101) G02F 2203/54 (20130101) G02F 2203/56 (20130101) Transmission H04B 10/506 (20130101)
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11599020 — Polymer-assisted synthesis of nanoparticles

US 11599020	Mirkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); Pengcheng Chen (Evanston, Illinois); Yuan Liu (Evanston, Illinois); Jingshan Du (Evanston, Illinois)
ABSTRACT	A method of preparing a metal nanoparticle can include depositing an ink on a substrate using nanolithography to form a polymer reactor, wherein the ink comprises at least one metalloporphyrin functionalized polymer comprising a metal ion, porphyrin, and a polyethylene oxide polymer; and thermally annealing the polymer nanoreactor under conditions sufficient to form the nanoparticle. The thermal annealing can include a first stage that includes annealing the polymer nanoreactor at a temperature of about 100° C. to about 350° C. for a time sufficient to aggregate the metal ions in the polymer reactor, and a second stage that includes annealing the aggregated polymer nanoreactor at a temperature of about 500° C. to about 600° C. for a time sufficient to reduce the metal ion and decompose a polymer component of the polymer nanoreactor to thereby form the metal nanoparticle.
FILED	Friday, March 27, 2020
APPL NO	16/832453
ART UNIT	1785 — Miscellaneous Articles, Stock Material
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/48 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/56 (20130101) C08K 2201/011 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/102 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class
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11599099 — System and method for constructing process plans for hybrid manufacturing with the aid of a digital computer

US 11599099	Behandish et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
INVENTOR(S)	Morad Behandish (Mountain View, California); Saigopal Nelaturi (Mountain View, California); Johan Dekleer (Los Altos, California)
ABSTRACT	A systematic approach to constructing process plans for hybrid manufacturing is provided. The process plans include arbitrary combinations of AM and SM processes. Unlike the suboptimal conventional practice, the sequence of AM and SM modalities is not fixed beforehand. Rather, all potentially viable process plans to fabricate a desired target part from arbitrary alternating sequences of pre-defined AM and SM modalities are explored in a systematic fashion. Once the state space of all process plans has been enumerated in terms of a partially ordered set of states, advanced artificial intelligence (AI) planning techniques are utilized to rapidly explore the state space, eliminate invalid process plans, for instance, process plans that make no physical sense, and optimize among the valid process plans using a cost function, for instance, manufacturing time and material or process costs.
FILED	Tuesday, June 16, 2020
APPL NO	16/903073
ART UNIT	2115 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) B33Y 50/02 (20141201) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4188 (20130101) Original (OR) Class G05B 19/40938 (20130101) G05B 2219/31001 (20130101) G05B 2219/35204 (20130101) G05B 2219/49007 (20130101) G05B 2219/49023 (20130101) Electric Digital Data Processing G06F 30/17 (20200101) G06F 2111/06 (20200101) G06F 2119/18 (20200101)
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11599109 — Mission modeling planning, and execution module (M2PEM) systems and methods

US 11599109	Scrapper et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Information Warfare Center (NIWC) Naval Information Warfare Center Pacific (NIWCPACIFIC) Space and Naval Warfare Systems Center (SPAWAR) National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	Naval Information Warfare Center Pacific (San Diego, California); California Institute Of Technology Jet Propulsion Laboratory (Pasadena, California)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Chris Scrapper (San Diego, California); Greg N Droge (San Diego, California); Alexander L Xydes (San Diego, California); Jean-Pierre de la Croix (Los Angeles, California); Amir Rahmani (Los Angeles, California); Joshua Vander Hook (Los Angeles, California); Grace Lim (Norwalk, California)
ABSTRACT	Methods and systems for accomplishing a mission using a plurality of unmanned vehicles can include graphically describing the mission tasks at a graphical user interface (GUI) using Business Process Model Notation (BPMN), and translating the graphical description into extensible machine language (XML) formatted robot operating system (ROS) instructions, which can be understood by each of the plurality of unmanned vehicles with a translator. An execution engine transmits the XML ROS instructions to a respective local controller on the respective unmanned vehicle. The BPMN graphical descriptor symbols can allow for planning of a mission by an end user that does not have expertise in the ROS domain, and that does not have an understanding of the ROS construct. The execution engine can provide feedback back to the GUI regarding mission execution. Based on the feedback, the graphical description can be modified while the mission is being accomplished.
FILED	Monday, May 06, 2019
APPL NO	16/403838
ART UNIT	3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Systems for Controlling or Regulating Non-electric Variables G05D 1/0016 (20130101) G05D 1/0027 (20130101) Original (OR) Class Electric Digital Data Processing G06F 8/40 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/067 (20130101)
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11599373 — Virtualized hardware and methods for leveraging virtualized hardware with munition support software

US 11599373	Walker et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Systems Command (NAVAIR)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Brad A. Walker (Tucson, Arizona); Richard D. Egbert (Sahuarita, Arizona); Frederick K. Jones (Oro Valley, Arizona); Jonathan Johansen (Oro Valley, Arizona)
ABSTRACT	An apparatus includes at least one memory configured to store a virtualization associated with a programming and test platform and a munition. The virtualization includes a virtual machine containing first software or firmware instructions associated with the programming and test platform and second software or firmware instructions that control behavior of the programming and test platform relative to the munition. The virtualization also includes a virtual representation of the munition. The virtualization further includes one or more virtual communication channels configured to communicatively couple the virtual machine and the virtual representation of the munition. The apparatus also includes at least one processor configured to execute the virtualization and simulate the programming and test platform and the munition on the apparatus.
FILED	Monday, February 17, 2020
APPL NO	16/792783
ART UNIT	2191 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 9/455 (20130101) Original (OR) Class G06F 9/44505 (20130101) G06F 9/45504 (20130101) G06F 11/261 (20130101) G06F 11/1484 (20130101) G06F 11/3664 (20130101) G06F 11/3692 (20130101) G06F 11/3696 (20130101) G06F 2201/815 (20130101)
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11599626 — Fast reconfiguring environment for mobile computing devices

US 11599626	Hartley et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Architecture Technology Corporation (Minneapolis, Minnesota)
ASSIGNEE(S)	ARCHITECTURE TECHNOLOGY CORPORATION (Minneapolis, Minnesota)
INVENTOR(S)	Timothy Hartley (Eden Prairie, Minnesota); Ranga Ramanujan (Medina, Minnesota); Jafar Al-Gharaibeh (Minneapolis, Minnesota)
ABSTRACT	An example method includes receiving an indication of a selection of a first application environment that includes a first virtual environment associated with a first security domain and is configured to isolate execution of software applications within the first application environment, suspending execution of a second application environment that includes a second virtual environment associated with a second security domain different from the first security domain, initiating execution of the first application environment, identifying information associated with the first security domain and provided by the first application environment that is to be sent to an external computing device associated with the first security domain, selecting communication network(s) from one or more communication networks that are each available to the mobile computing device for data communication, encrypting, based on the first security domain and network(s), the information, and sending, to the external computing device via the network(s), the encrypted information.
FILED	Wednesday, March 11, 2020
APPL NO	16/815295
ART UNIT	2497 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 3/067 (20130101) G06F 3/0622 (20130101) G06F 3/0659 (20130101) G06F 3/0664 (20130101) G06F 21/53 (20130101) Original (OR) Class G06F 21/74 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 43/0829 (20130101) H04L 43/0864 (20130101) H04L 43/0882 (20130101) H04L 63/18 (20130101) H04L 63/105 (20130101) H04L 63/0245 (20130101) H04L 63/0272 (20130101) H04L 63/0428 (20130101) H04L 67/34 (20130101) Wireless Communication Networks H04W 12/033 (20210101)
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11599699 — System and method for autonomous printed circuit board design using machine learning techniques

US 11599699	Roberto et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Cadence Design Systems, Inc. (San Jose, California)
ASSIGNEE(S)	Cadence Design Systems, Inc. (San Jose, California)
INVENTOR(S)	Luke Roberto (Brookline, Massachusetts); Joydeep Mitra (Austin, Texas); Taylor Elsom Hogan (Boston, Massachusetts); Shang Li (Wakefield, Massachusetts); Zachary Joseph Zumbo (Brookline, Massachusetts); John Robert Murphy (Boston, Massachusetts)
ABSTRACT	The present disclosure relates to systems and methods for floorplanning using machine learning techniques. Embodiments may include receiving an electronic design and analyzing the electronic design using a reinforcement learning agent. Embodiments may further include recommending a first action wherein the first action includes at least one of a place agent action, a via agent action, or a route agent action. Embodiments may also include updating the electronic design based upon, at least in part, the first action to generate an updated electronic design. Embodiments may further include analyzing the updated electronic design using the reinforcement learning agent and recommending a second action wherein the second action includes at least one of a place agent action, a via agent action, or a route agent action. Embodiments may also include updating the updated electronic design based upon the second action to generate a second updated electronic design.
FILED	Monday, February 10, 2020
APPL NO	16/785972
ART UNIT	2851 — Printing/Measuring and Testing
CURRENT CPC	Electric Digital Data Processing G06F 30/31 (20200101) Original (OR) Class G06F 2115/12 (20200101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101)
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11599795 — Reducing the cost of n modular redundancy for neural networks

US 11599795	Bose et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Pradip Bose (Yorktown Heights, New York); Alper Buyuktosunoglu (Yorktown Heights, New York); Schuyler Eldridge (Yorktown Heights, New York); Karthik V Swaminathan (Yorktown Heights, New York); Augusto Vega (Yorktown Heights, New York); Swagath Venkataramani (Yorktown Heights, New York)
ABSTRACT	An N modular redundancy method, system, and computer program product include a computer-implemented N modular redundancy method for neural networks, the method including selectively replicating the neural network by employing one of checker neural networks and selective N modular redundancy (N-MR) applied only to critical computations.
FILED	Wednesday, November 08, 2017
APPL NO	15/806393
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) G06N 3/082 (20130101) Original (OR) Class
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11599816 — Method and system for identifying target platform

US 11599816	Frank
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	BAE Systems Information And Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Ronald James Frank (San Dimas, California)
ABSTRACT	A method and system is disclosed for determining a probability that an encountered platform was of a specific type given that a plurality of emitters exist on the platform and each emitter has a computed probability that it is of each of a set of types. A preprocessing stage operates on a description of the environment and determines the probability of a set of events that are independent of any observation. A runtime processing stage uses the terms computed in the preprocessing stage along with data assembled from a set of observations to determine the conditional probability that a particular platform type was the type encountered.
FILED	Tuesday, December 24, 2019
APPL NO	16/726532
ART UNIT	2156 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/2272 (20190101) G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Original (OR) Class
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11599998 — Machine learning systems and methods for assessment, healing prediction, and treatment of wounds

US 11599998	Fan et al.
FUNDED BY	Department of Defense (DOD) Defense Health Agency (DHA) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA)
APPLICANT(S)	SPECTRAL MD, INC. (Dallas, Texas)
ASSIGNEE(S)	SPECTRAL MD, INC. (Dallas, Texas)
INVENTOR(S)	Wensheng Fan (Plano, Texas); John Michael DiMaio (Dallas, Texas); Jeffrey E. Thatcher (Irving, Texas); Peiran Quan (Dallas, Texas); Faliu Yi (Allen, Texas); Kevin Plant (Dallas, Texas); Ronald Baxter (Grand Prairie, Texas); Brian McCall (Dallas, Texas); Zhicun Gao (Plano, Texas); Jason Dwight (Dallas, Texas)
ABSTRACT	Machine learning systems and methods are disclosed for prediction of wound healing, such as for diabetic foot ulcers or other wounds, and for assessment implementations such as segmentation of images into wound regions and non-wound regions. Systems for assessing or predicting wound healing can include a light detection element configured to collect light of at least a first wavelength reflected from a tissue region including a wound, and one or more processors configured to generate an image based on a signal from the light detection element having pixels depicting the tissue region, determine reflectance intensity values for at least a subset of the pixels, determine one or more quantitative features of the subset of the plurality of pixels based on the reflectance intensity values, and generate a predicted or assessed healing parameter associated with the wound over a predetermined time interval.
FILED	Friday, September 04, 2020
APPL NO	17/013336
ART UNIT	2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/445 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/30088 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/30 (20180101)
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11600203 — Non-lethal weapons modular human surrogate testing device and method

US 11600203	Sedberry et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) United States Marine Corps (USMC) Joint Intermediate Force Capabilities Office (JIFCO) Non-Lethal Weapons Directorate (JNLWD)
APPLICANT(S)	CFD Research Corporation (Hunstville, Alabama)
ASSIGNEE(S)	CFD Research Corporation (Huntsville, Alabama)
INVENTOR(S)	David Keith Sedberry (Huntsville, Alabama); Vincent J. Harrand (Huntsville, Alabama); Phillip E. Whitley (Huntsville, Alabama); Andrzej Przekwas (Huntsville, Alabama)
ABSTRACT	A modular surrogate can include: a body having an external body surface with an anatomical shape, wherein the body includes an internal chamber with at least one port formed in the body extending inwardly; at least one anatomical module having an external module portion and a module stem coupled thereto, the module stem being received into a corresponding module port of the at least one port, the external module portion having an external module surface with an anatomical shape, the external body surface matches with the external module surface to provide a continuous anatomical shape; at least one sensor located in the at least one anatomical module; and at least one controller, wherein when the at least one anatomical module is coupled with the body, the at least one sensor is capable of being operably coupled with the at least one controller.
FILED	Tuesday, November 26, 2019
APPL NO	16/696997
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 13/0056 (20130101) F41H 13/0075 (20130101) F41H 13/0081 (20130101) Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 21/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/00 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/34 (20130101) Original (OR) Class
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11600318 — Memory array with reduced leakage current

US 11600318	Golke
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Honeywell International Inc. (Charlotte, North Carolina)
ASSIGNEE(S)	Honeywell International Inc. (Charlotte, North Carolina)
INVENTOR(S)	Keith Golke (Minneapolis, Minnesota)
ABSTRACT	An apparatus for reading a bit of a memory array includes a bit cell column, voltage enhancement circuitry, and control circuitry. The voltage enhancement circuitry is configured to couple a bitline to a reference node. The control circuitry is configured to, in response to a read request for a bitcell element of a plurality of bitcell elements, couple a current source to the bitcell column such that a read current from the current source flows from the source line, through the bitcell column and the voltage enhancement circuitry, to the reference node and determine a state for the bitcell element based on a voltage between the source line and the reference node. The voltage enhancement circuitry is configured to generate, when the read current flows through the voltage enhancement circuitry, a voltage at the bitline that is greater than a voltage at the reference node.
FILED	Friday, October 08, 2021
APPL NO	17/497483
ART UNIT	2824 — Semiconductors/Memory
CURRENT CPC	Static Stores G11C 11/4074 (20130101) G11C 11/4094 (20130101) Original (OR) Class G11C 11/4099 (20130101) G11C 17/126 (20130101)
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11600332 — Programmable atomic operator resource locking

US 11600332	Brewer
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)	Micron Technology, Inc. (Boise, Idaho)
INVENTOR(S)	Tony Brewer (Plano, Texas)
ABSTRACT	Devices and techniques for programmable atomic operator resource locking are described herein. A request for a programmable atomic operator (PAO) can be received at a memory controller that includes a programmable atomic unit (PAU). Here, the request includes an identifier for the PAO and a memory address. The memory addressed is processed to identify a lock value. A verification can be performed to determine that the lock value indicates that there is no lock corresponding to the memory address. Then, the lock value is set to indicate that there is now a lock corresponding to the memory address and the PAO is invoked based on the identifier for the PAO. In response to completion of the PAO, the lock value is set to indicate that there is no longer a lock corresponding to the memory address.
FILED	Tuesday, October 20, 2020
APPL NO	17/075384
ART UNIT	2183 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 9/526 (20130101) G06F 12/0815 (20130101) G06F 12/0862 (20130101) G06F 12/0875 (20130101) G06F 13/1605 (20130101) G06F 13/1668 (20130101) G06F 2212/1024 (20130101) Static Stores G11C 16/08 (20130101) G11C 16/26 (20130101) G11C 16/102 (20130101) Original (OR) Class G11C 16/3459 (20130101)
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11600373 — Biodosimetry panels and methods

US 11600373	Blakely et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Health and Human Services (HHS)
APPLICANT(S)	MESO SCALE TECHNOLOGIES, LLC (Rockville, Maryland); THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland)
ASSIGNEE(S)	MESO SCALE TECHNOLOGIES, LLC. (Rockville, Maryland); THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland)
INVENTOR(S)	William F. Blakely (Silver Spring, Maryland); Eli N. Glezer (Del Mar, California); John Kenten (Boyds, Maryland); Sudeep Kumar (Gaithersburg, Maryland); Anu Mathew (North Potomac, Maryland); Natalia I. Ossetrova (Silver Spring, Maryland); George Sigal (Rockville, Maryland)
ABSTRACT	The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
FILED	Thursday, August 29, 2019
APPL NO	16/555271
ART UNIT	2857 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3273 (20130101) G01N 33/6893 (20130101) G01N 35/00 (20130101) G01N 2333/70535 (20130101) G01N 2333/70578 (20130101) G01N 2800/40 (20130101) G01N 2800/60 (20130101) Measurement of Nuclear or X-radiation G01T 1/00 (20130101) G01T 1/02 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) Original (OR) Class
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11600402 — Residue free electrically conductive material

US 11600402	Cumby et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Brad L Cumby (Liberty Township, Ohio); Christopher Tabor (Kettering, Ohio)
ABSTRACT	A deformable yet mechanically resilient microcapsule having electrical properties, a method of making the microcapsules, and a circuit component including the microcapsules. The microcapsule containing a gallium liquid metal alloy core having from about 60 to about 100 wt.% gallium and at least one alloying metal, and a polymeric shell encapsulating the liquid core, said polymeric shell having conductive properties.
FILED	Thursday, June 02, 2022
APPL NO	17/830444
ART UNIT	1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/08 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) H01B 1/22 (20130101) H01B 5/00 (20130101) Original (OR) Class H01B 13/0026 (20130101)
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11600496 — In-situ p-type activation of III-nitride films grown via metal organic chemical vapor deposition

US 11600496	Razeghi
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	Manijeh Razeghi (Wilmette, Illinois)
ABSTRACT	Methods for activating a p-type dopant in a group III-Nitride semiconductor are provided. In embodiments, such a method comprises annealing, in situ, a film of a group III-Nitride semiconductor comprising a p-type dopant formed via metalorganic chemical vapor deposition (MOCVD) at a first temperature for a first period of time under an atmosphere comprising NH₃and N₂; and cooling, in situ, the film of the group III-Nitride semiconductor to a second temperature that is lower than the first temperature under an atmosphere comprising N₂in the absence of NH₃, to form an activated p-type group III-Nitride semiconductor film.
FILED	Wednesday, November 18, 2020
APPL NO	16/951376
ART UNIT	2812 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02579 (20130101) H01L 21/3245 (20130101) Original (OR) Class
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11600762 — Fabrication of high-temperature superconducting striated tape combinations

US 11600762	Prestigiacomo et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Joseph C. Prestigiacomo (Springfield, Virginia); Raymond C. Y. Auyeung (Alexandria, Virginia); Michael S. Osofsky (Clarksville, Maryland)
ABSTRACT	This disclosure teaches methods for making high-temperature superconducting striated tape combinations and the product high-temperature superconducting striated tape combinations. This disclosure describes an efficient and scalable method for aligning and bonding two superimposed high-temperature superconducting (HTS) filamentary tapes to form a single integrated tape structure. This invention aligns a bottom and top HTS tape with a thin intervening insulator layer with microscopic precision, and electrically connects the two sets of tape filaments with each other. The insulating layer also reinforces adhesion of the top and bottom tapes, mitigating mechanical stress at the electrical connections. The ability of this method to precisely align separate tapes to form a single tape structure makes it compatible with a reel-to-reel production process.
FILED	Wednesday, December 12, 2018
APPL NO	16/218471
ART UNIT	1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0016 (20130101) B23K 3/0623 (20130101) B23K 35/0222 (20130101) B23K 35/264 (20130101) B23K 2101/42 (20180801) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/681 (20130101) H01L 21/6836 (20130101) H01L 21/6838 (20130101) H01L 21/67092 (20130101) H01L 24/03 (20130101) H01L 39/24 (20130101) H01L 39/143 (20130101) Original (OR) Class H01L 39/248 (20130101) H01L 2221/68309 (20130101) H01L 2224/0311 (20130101) H01L 2224/03003 (20130101) H01L 2224/05109 (20130101) H01L 2224/05113 (20130101) H01L 2924/014 (20130101) H01L 2924/01322 (20130101)
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11600837 — Crosslinked membrane for anion exchange applications

US 11600837	Liberatore et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	The University of Toledo (Toledo, Ohio)
ASSIGNEE(S)	The University of Toledo (Toledo, Ohio)
INVENTOR(S)	Matthew Liberatore (Toledo, Ohio); George Amobi Ozioko (Toledo, Ohio); Karl Schoeps (Toledo, Ohio)
ABSTRACT	Crosslinked membranes for anion exchange applications, and methods of making and using the same, are described.
FILED	Tuesday, October 08, 2019
APPL NO	16/595871
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/07 (20170101) B01J 47/12 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/56 (20130101) C08F 236/14 (20130101) C08F 2810/20 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 5/2231 (20130101) C08J 2333/26 (20130101) C08J 2347/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/103 (20130101) Original (OR) Class H01M 8/1027 (20130101) H01M 8/1072 (20130101) H01M 2008/1095 (20130101)
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11601442 — System and method associated with expedient detection and reconstruction of cyber events in a compact scenario representation using provenance tags and customizable policy

US 11601442	Sekar et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA) Mitigating APT Reasoning with Provenance in Large Enterprise Networks (MARPLE)
APPLICANT(S)	The Research Foundation for the State University of New York (Albany, New York); The University of Illinois at Chicago (Chicago, Illinois)
ASSIGNEE(S)	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Chicago, Illinois)
INVENTOR(S)	Ramasubramanian Sekar (East Setauket, New York); Junao Wang (Centereach, New York); Md Nahid Hossain (Stony Brook, New York); Sadegh M. Milajerdi (Chicago, Illinois); Birhanu Eshete (Chicago, Illinois); Rigel Gjomemo (Chicago, Illinois); V. N. Venkatakrishnan (Chicago, Illinois); Scott Stoller (Setauket, New York)
ABSTRACT	A system associated with detecting a cyber-attack and reconstructing events associated with a cyber-attack campaign, is disclosed. The system performs various operations that include receiving an audit data stream associated with cyber events. The system identifies trustworthiness values in a portion of data associated with the cyber events and assigns provenance tags to the portion of the data based on the identified trustworthiness values. An initial visual representation is generated based on the assigned provenance tags to the portion of the data. The initial visual representation is condensed based on a backward traversal of the initial visual representation in identifying a shortest path from a suspect node to an entry point node. A scenario visual representation is generated that specifies nodes most relevant to the cyber events associated with the cyber-attack based on the identified shortest path. A corresponding method and computer-readable medium are also disclosed.
FILED	Monday, August 19, 2019
APPL NO	16/544401
ART UNIT	2496 — Electrical Circuits and Systems
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class H04L 63/1425 (20130101)
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Department of Energy (DOE)

11596894 — Process for purifying hydrogen gas for use in fuel cells

US 11596894	Morris et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	NuMat Technologies Inc. (Skokie, Illinois)
ASSIGNEE(S)	NuMat Technologies Inc. (Skokie, Illinois)
INVENTOR(S)	William Morris (Chicago, Illinois); William Joseph Hoover (Chicago, Illinois); Ross James Verploegh (Buffalo Grove, Illinois); Edwin Alfonso Argueta Fajardo (Chicago, Illinois); Alexander Matthew Ruddick (Chicago, Illinois)
ABSTRACT	The invention generally relates to a process for purifying a hydrogen gas for use in a fuel cell. The process involves taking a hydrogen feed stream from a high-pressure tank and passing it through a purifier comprising an adsorbent to provide a purified hydrogen stream which is sent to a fuel cell. A particular adsorbent which can be used is a metal-organic framework composition. The adsorbent can be housed in a device such as a canister or cartridge having an inlet and outlet port.
FILED	Thursday, May 20, 2021
APPL NO	17/325960
ART UNIT	1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 53/0415 (20130101) Original (OR) Class B01D 2253/204 (20130101) B01D 2253/308 (20130101) B01D 2253/342 (20130101) B01D 2256/16 (20130101) B01D 2257/40 (20130101) B01D 2257/50 (20130101) B01D 2257/304 (20130101) B01D 2257/702 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) B01J 20/2808 (20130101) B01J 20/28061 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0606 (20130101)
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11596912 — Single stage clarifier and mixing assembly

US 11596912	Werner
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
INVENTOR(S)	Joshua Michael Werner (Lexington, Kentucky)
ABSTRACT	A single stage clarifier and mixing assembly includes a housing, a mixing section within the housing and a clarifier section within the housing. The mixing section includes a mixing chamber having (a) an inlet, adapted for delivering an inlet stream to the mixing chamber, at an upper end, and (b) a mixing section outlet at a lower end. The clarifier section extends concentrically around the mixing section. The single stage clarifier and mixing assembly also includes an agitator adapted for mixing the inlet stream in the mixing chamber.
FILED	Wednesday, November 11, 2020
APPL NO	17/095260
ART UNIT	1778 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 17/0217 (20130101) B01D 21/08 (20130101) B01D 21/0045 (20130101) B01D 21/0057 (20130101) B01D 21/0087 (20130101) B01D 21/286 (20130101) B01D 21/2427 (20130101) Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 27/86 (20220101) B01F 27/91 (20220101) B01F 27/113 (20220101) B01F 33/811 (20220101) Original (OR) Class
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11596916 — Tailoring of pores in aerogels using 3D printed structures

US 11596916	Chandrasekaran et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Swetha Chandrasekaran (Dublin, California); Theodore F. Baumann (Discovery Bay, California); Juergen Biener (San Leandro, California); Patrick Campbell (Oakland, California); James S. Oakdale (Castro Valley, California); Marcus A. Worsley (Hayward, California)
ABSTRACT	In one embodiment, a method includes acquiring a three-dimensional printed template created using an additive manufacturing technique, infilling the template with an aerogel precursor solution, allowing formation of a sol-gel, and converting the sol-gel to an aerogel. In another embodiment, a product includes an aerogel having inner channels corresponding to outer walls of a three-dimensional printed template around which the aerogel was formed.
FILED	Tuesday, July 12, 2016
APPL NO	15/208506
ART UNIT	1767 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0091 (20130101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Non-metallic Elements; Compounds Thereof; C01B 13/18 (20130101) C01B 32/05 (20170801)
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11596920 — Enhanced microchannel or mesochannel devices and methods of additively manufacturing the same

US 11596920	TeGrotenhuis et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Ward E. TeGrotenhuis (Richland, Washington); Paul H. Humble (Richland, Washington); Christopher K. Clayton (Richland, Washington); Timothy G. Veldman (Richland, Washington); Robert S. Wegeng (Richland, Washington); Richard F. Zheng (Richland, Washington)
ABSTRACT	Chemical processors are configured to reduce mass, work in conjunction with solar concentrators, and/or house porous inserts in microchannel or mesochannel devices made by additive manufacturing. Methods of making chemical processors containing porous inserts by additive manufacturing are also disclosed.
FILED	Monday, April 05, 2021
APPL NO	17/222947
ART UNIT	1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0093 (20130101) B01J 19/248 (20130101) Original (OR) Class B01J 19/2415 (20130101) B01J 2219/00792 (20130101) B01J 2219/1941 (20130101) B01J 2219/2401 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 7/08 (20130101) B22F 10/00 (20210101) B22F 10/20 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201)
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11596928 — Scalable Pt cluster and RuO2 heterojunction anode catalysts

US 11596928	Stamenkovic et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	Vojislav Stamenkovic (Naperville, Illinois); Rongyue Wang (Naperville, Illinois); Dusan Strmcnik (Woodridge, Illinois)
ABSTRACT	A synthesis process for forming nanodendrites. The nanodendrites are utilized in a process to form a heterojunction catalyst. Nanodendrites may include PtRu₈nanodendrites that can be oxidized through annealing to form PtRuO₂. One heterojunction catalyst comprises PtRuO₂on a carbon support.
FILED	Thursday, September 26, 2019
APPL NO	16/584385
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/56 (20130101) Original (OR) Class B01J 37/04 (20130101) B01J 37/08 (20130101) B01J 37/009 (20130101) B01J 2523/821 (20130101) B01J 2523/828 (20130101)
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11596935 — Catalytic polymer processing

US 11596935	Delferro et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Ames Laboratory (AL) Federally Funded Research and Development Center (FFRDC) Operated by Iowa State University (IASTATE) at Ames, IA Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	Massimiliano Delferro (Chicago, Illinois); Magali S. Ferrandon (Steger, Illinois); Kenneth R. Poeppelmeier (Evanston, Illinois); Aaron D. Sadow (Ames, Iowa); Susannah Scott (Goleta, California); Anne M. LaPointe (Lemont, Illinois); Geoffrey Coates (Lemont, Illinois)
ABSTRACT	A method of upcycling polymers to useful hydrocarbon materials. A catalyst with nanoparticles on a substrate selectively docks and cleaves longer hydrocarbon chains over shorter hydrocarbon chains. The catalyst includes metal nanoparticles in an order array on a substrate.
FILED	Wednesday, January 22, 2020
APPL NO	16/749885
ART UNIT	1763 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/42 (20130101) B01J 35/0013 (20130101) Original (OR) Class B01J 35/023 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/50 (20130101) C08F 10/02 (20130101)
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11597683 — Method for sulfur removal from coal fly ash

US 11597683	Wang et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Bu Wang (Madison, Wisconsin); Raghavendra Ragipani (Madison, Wisconsin)
ABSTRACT	A method of reducing sulfur concentration in fly ash, flue gas desulfurization (FGD) ash, and mixtures thereof by contacting the fly ash, FGD ash, or mixtures thereof with an aqueous acidic solution, for a time, at a temperature, and at a liquid-to-solid ratio wherein the sulfur concentration within the fly ash, FGD ash, or mixture thereof is reduced to no more than 5 wt % SO₃based on the total weight of dry fly ash, FGD ash, or mixture thereof so treated.
FILED	Monday, May 11, 2020
APPL NO	16/871508
ART UNIT	1731 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 18/08 (20130101) C04B 18/088 (20130101) C04B 18/106 (20130101) Original (OR) Class C04B 20/023 (20130101)
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11598327 — Compressor system with heat recovery

US 11598327	Torrey et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	David Allan Torrey (Ballston Spa, New York); Douglas C. Hofer (Niskayuna, New York); Bugra Han Ertas (Niskayuna, New York)
ABSTRACT	A system includes a first working fluid compressor configured to pressurize a working fluid, and a prime mover coupled to the first working fluid compressor and configured to provide a mechanical input into the first working fluid compressor. An exhaust assembly is coupled to the prime mover and is configured to receive exhaust heat from the prime mover, the exhaust assembly including a generator configured to generate electric current based on the exhaust heat received by the exhaust assembly. A second working fluid compressor includes an electric motor electrically and synchronously coupled to the generator and configured to pressurize the working fluid.
FILED	Tuesday, November 05, 2019
APPL NO	16/674614
ART UNIT	3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Positive-displacement Machines for Liquids; Pumps F04B 35/04 (20130101) F04B 41/06 (20130101) Original (OR) Class
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11598536 — Systems with multi-circuited, phase-change composite heat exchangers

US 11598536	Kozubal et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S)	Eric Kozubal (Superior, Colorado); Jason David Woods (Boulder, Colorado); Eric Jason Bonnema (Littleton, Colorado); Ramin Teimouri Faramarzi (Pacific Palisades, California)
ABSTRACT	A system comprising a first plurality of microchannels, a second plurality of microchannels in thermal communication with the first plurality of microchannels such that the first plurality of microchannels and second plurality of microchannels form a heat exchanger, and a phase change composite in thermal communication with the heat exchanger and methods of operating are disclosed herein.
FILED	Tuesday, April 07, 2020
APPL NO	16/842076
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 5/001 (20130101) F24F 5/0021 (20130101) Original (OR) Class
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11598890 — Ion beam profiling system and related methods

US 11598890	Taylor
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE) Idaho National Laboratory (INL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
INVENTOR(S)	Chase N. Taylor (Idaho Falls, Idaho)
ABSTRACT	An ion beam profiling system include a beam profiling element, an ion sensitive element electrically isolated from the beam profiling element, an ion source configured to emit an ion beam at the beam profiling element and the ion sensitive element, and a current measuring device coupled to the ion sensitive element. The beam profiling element includes a plate of material having two parallel major surfaces, a first slit aperture extending through the plate of material and having a first longitudinal length extending in a direction parallel to the two parallel major surfaces, and a second slit aperture extending through the plate of material and having a second longitudinal length extending in a direction parallel to the two parallel major surfaces, wherein the first longitudinal length of the first slit aperture is perpendicular to the second longitudinal length of the second slit aperture.
FILED	Wednesday, June 17, 2020
APPL NO	16/946344
ART UNIT	2881 — Optics
CURRENT CPC	Measurement of Nuclear or X-radiation G01T 1/2921 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 37/243 (20130101) H01J 37/252 (20130101) H01J 37/3171 (20130101) H01J 2237/245 (20130101) H01J 2237/24535 (20130101) H01J 2237/24542 (20130101)
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11598946 — Widefield three-dimensional microscopy with a quantum entanglement light source

US 11598946	Bond et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
INVENTOR(S)	Tiziana C. Bond (Livermore, California); Matthew A. Horsley (Danville, California); Shervin Kiannejad (Brentwood, California); Ted Laurence (Livermore, California); Ty Samo (Walnut Creek, California); Peter Weber (Berkeley, California); Xiyu Yi (Livermore, California)
ABSTRACT	Devices, systems and methods for widefield three-dimensional (3D) microscopy with a quantum entanglement light source are described. An example method includes generating a first set of photons and a second set of photons, wherein each of the photons in the first set is quantum entangled with a corresponding photon in the second set, directing the second set of photons toward a sample and simultaneously directing the first set of photons toward a first two-dimensional (2D) detector, detecting, from the sample, a plurality of photons at a second 2D detector, analyzing detections from the first and second 2D detectors to determine coincidence information, and determining one or more characteristics associated with at least a three-dimensional (3D) section of the sample based on collective detections at the first and the second 2D detectors.
FILED	Wednesday, October 14, 2020
APPL NO	17/070654
ART UNIT	2872 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/361 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3501 (20130101) Pictorial Communication, e.g Television H04N 13/254 (20180501)
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11599470 — Last-level collective hardware prefetching

US 11599470	Michelogiannakis et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Georgios Michelogiannakis (Berkeley, California); John Shalf (Oakland, California)
ABSTRACT	A last-level collective hardware prefetcher (LLCHP) is described. The LLCHP is to detect a first off-chip memory access request by a first processor core of a plurality of processor cores. The LLCHP is further to determine, based on the first off-chip memory access request, that first data associated with the first off-chip memory access request is associated with second data of a second processor core of the plurality of processor cores. The LLCHP is further to prefetch the first data and the second data based on the determination.
FILED	Wednesday, November 06, 2019
APPL NO	17/295797
ART UNIT	2138 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 12/0811 (20130101) G06F 12/0835 (20130101) G06F 12/0862 (20130101) Original (OR) Class G06F 15/7825 (20130101) G06F 2212/6026 (20130101)
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11600478 — Thermionic converter and methods of making and using same

US 11600478	Yacout et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S)	Abdellatif M. Yacout (Naperville, Illinois); Sumit Bhattacharya (Darien, Illinois)
ABSTRACT	Provided herein are thermionic converters that are capable of operating at lower temperatures and with increased efficiency as compared to conventional thermionic converters. Also provided are methods of using and making the thermionic converters of the disclosure.
FILED	Wednesday, February 05, 2020
APPL NO	16/783105
ART UNIT	2879 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) Original (OR) Class
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11600733 — System and method for shingling wafer strips connected in parallel

US 11600733	Caswell
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	SUNPOWER CORPORATION (San Jose, California)
ASSIGNEE(S)	SUNPOWER CORPORATION (San Jose, California)
INVENTOR(S)	Nathaniel Caswell (Sunnyvale, California)
ABSTRACT	A solar device includes a first string of first solar wafers, wherein a plurality of the first solar wafers each overlap with at least one vertically adjacent solar wafer from the first string. Additionally, the solar device includes a second string of second solar wafers, wherein a plurality of the second solar wafers each overlap with at least one vertically adjacent solar wafer from the second string, wherein a plurality of the first solar wafers overlap with one or more of the plurality of second solar wafers to electrically connect horizontally adjacent solar wafers in parallel.
FILED	Friday, July 09, 2021
APPL NO	17/305540
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/042 (20130101) H01L 31/068 (20130101) H01L 31/0465 (20141201) H01L 31/0508 (20130101) Original (OR) Class
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11600838 — Ion-selective membrane for redox flow batteries

US 11600838	Fujimoto et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Cy Fujimoto (Albuquerque, New Mexico); Ehren Baca (Albuquerque, New Mexico)
ABSTRACT	A fluoro sulfonated poly(phenylene) was rationally designed with an external hydrophobic shell and internal hydrophilic core in order to improve the durability and ion selectivity of a hydrocarbon membrane for vanadium redox flow batteries (VRFBs). The polymer was designed to prevent hydrophilic polymer chain aggregation by attaching acid moieties onto the polymer backbone, while functionalizing the external polymer shell with hydrophobic side chains to prevent excessive vanadium crossover associated with cation exchange membranes. As an example, the hydrophobic shell can be provided by pentafluorobenzoyl group functionalization of the pendent aryl groups on a Diels Alder poly(phenylene) backbone, while the internal polymer chain can contain sulfonic acid moieties to impart hydrophilic character.
FILED	Monday, August 02, 2021
APPL NO	17/391508
ART UNIT	1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/20 (20130101) Original (OR) Class H01M 8/1004 (20130101) H01M 2300/0005 (20130101)
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11600856 — Solution-assisted densification of NaSICON ceramics

US 11600856	Bock et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Jonathan Anton Bock (Albuquerque, New Mexico); Erik David Spoerke (Albuquerque, New Mexico); Harlan James Brown-Shaklee (Albbuquerque, New Mexico); Leo J. Small (Albuquerque, New Mexico)
ABSTRACT	A sodium-ion conducting NaSICON ceramic can be densified via the addition of a solvent to a NaSICON powder and subsequent pressing under high pressure and mild heat. Densification to ˜90% relative density can be achieved, providing a path toward low-temperature fabrication of Na-ion conductors.
FILED	Wednesday, January 20, 2021
APPL NO	17/153607
ART UNIT	1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/447 (20130101) C04B 35/645 (20130101) C04B 35/6264 (20130101) C04B 2235/447 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/054 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) H01M 2300/0091 (20130101)
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11600859 — Electrolyte for stable cycling of rechargeable alkali metal and alkali ion batteries

US 11600859	Cao et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Xia Cao (Richland, Washington); Ji-Guang Zhang (Richland, Washington); Wu Xu (Richland, Washington)
ABSTRACT	Localized superconcentrated electrolytes (LSEs) and electrochemical devices including the LSEs are disclosed. The LSE includes an active salt, a solvent in which the active salt is soluble, and a diluent in which the active salt is insoluble or poorly soluble, wherein the diluent includes a fluorinated orthoformate.
FILED	Tuesday, November 19, 2019
APPL NO	16/688929
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2300/0025 (20130101)
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11600870 — Systems and methods for evaluating electrolyte wetting and distribution

US 11600870	Dou et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Liminal Insights, Inc. (Emeryville, California)
ASSIGNEE(S)	Liminal Insights, Inc. (Emeryville, California)
INVENTOR(S)	Shan Dou (Berkeley, California); Andrew G. Hsieh (Berkeley, California); Shaurjo Biswas (El Cerrito, California); Barry J. Van Tassell (El Cerrito, California); Elizabeth M. Lee (Oakland, California); Dennis Yu (Berkeley, California); Jason Y. Yu (Emeryville, California)
ABSTRACT	Systems and techniques for measuring process characteristics including electrolyte distribution in a battery cell. A non-destructive method for analyzing a battery cell includes determining acoustic features at two or more locations of the battery cell, the acoustic features based on one or more of acoustic signals travelling through at least one or more portions of the battery cell during one or more points in time or responses to the acoustic signals obtained during one or more points in time, wherein the one or more points in time correspond to one or more stages of electrolyte distribution in the battery cell. One or more characteristics of the battery cell are determined based on the acoustic features at the two or more locations of the battery cell.
FILED	Monday, March 23, 2020
APPL NO	16/826718
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/0654 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/484 (20130101) Original (OR) Class
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11601472 — One-way transfer device with secure reverse channel

US 11601472	Lee et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Fend Incorporated (Arlington, Virginia)
ASSIGNEE(S)	Fend Incorporated (Arlington, Virginia)
INVENTOR(S)	Sang Cheon Lee (Ashburn, Virginia); Colin Patrick Dunn (Falls Church, Virginia); Paul Carroll (Chevy Chase, Maryland); Philip Quebe (Middlebrook, Virginia)
ABSTRACT	A data diode provides a flexible device for collecting data from a data source and transmitting the data to a data destination using one-way data transmission across a main channel. On-board processing elements allow the data diode to identify automatically the type of connectivity provided to the data diode and configure the data diode to handle the identified type of connectivity. Either or both of the inbound and outbound side of the data diode may comprise one or both of wired and wireless communication interfaces. A secure reverse channel, separate from the main channel, allows carefully predetermined communications from the data destination to the data source.
FILED	Monday, August 02, 2021
APPL NO	17/444268
ART UNIT	2435 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0643 (20130101) H04L 9/3215 (20130101) H04L 63/18 (20130101) Original (OR) Class
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11601601 — Optical array for high-quality imaging in harsh environments

US 11601601	Baba et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Justin S. Baba (Knoxville, Tennessee); Philip R. Bingham (Knoxville, Tennessee); David S. Bolme (Knoxville, Tennessee); Matthew R. Eicholtz (Lakeland, Florida); Regina Kay Ferrell (Knoxville, Tennessee); Christi R. Johnson (Kingston, Tennessee); Hector J. Santos-Villalobos (Knoxville, Tennessee)
ABSTRACT	Methods and apparatus are disclosed for producing high quality images in uncontrolled or impaired environments. In some examples of the disclosed technology, groups of cameras for high dynamic range (HDR), polarization diversity, and optional other diversity modes are arranged to concurrently image a common scene. For example, in a vehicle checkpoint application, HDR provides discernment of dark objects inside a vehicle, while polarization diversity aids in rejecting glare. Spectral diversity, infrared imaging, and active illumination can be applied for better imaging through a windshield. Preprocessed single-camera images are registered and fused. Faces or other features of interest can be detected in the fused image and identified in a library. Impairments can include weather, insufficient or interfering lighting, shadows, reflections, window glass, occlusions, or moving objects.
FILED	Monday, August 10, 2020
APPL NO	16/989222
ART UNIT	2632 — Digital Communications
CURRENT CPC	Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/007 (20130101) G06T 5/008 (20130101) G06T 5/50 (20130101) G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) G06T 2207/10028 (20130101) G06T 2207/10048 (20130101) G06T 2207/20052 (20130101) G06T 2207/20076 (20130101) G06T 2207/20084 (20130101) G06T 2207/20208 (20130101) G06T 2207/20221 (20130101) G06T 2207/30201 (20130101) G06T 2207/30268 (20130101) Image or Video Recognition or Understanding G06V 10/147 (20220101) G06V 20/54 (20220101) G06V 20/59 (20220101) G06V 40/166 (20220101) Pictorial Communication, e.g Television H04N 5/33 (20130101) H04N 5/247 (20130101) H04N 5/2256 (20130101) H04N 5/2258 (20130101) H04N 5/2355 (20130101) Original (OR) Class H04N 13/327 (20180501)
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National Science Foundation (NSF)

11596713 — Tissue-engineered intervertebral disc with living cells

US 11596713	Bonassar et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)	CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S)	Lawrence J. Bonassar (Ithaca, New York); Roger Hartl (New York, New York); Robert D. Bowles (Ithaca, New York); Harry H. Gebhard (Tuebingen, Germany)
ABSTRACT	The present invention relates to a tissue-engineered intervertebral disc (IVD) comprising a nucleus pulposus structure comprising a first population of living cells and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and collagen.
FILED	Wednesday, November 25, 2020
APPL NO	17/105154
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/442 (20130101) A61F 2002/444 (20130101) A61F 2002/445 (20130101) A61F 2002/4435 (20130101) A61F 2002/4445 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/32 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/20 (20130101) A61L 27/22 (20130101) A61L 27/24 (20130101) A61L 27/44 (20130101) A61L 27/52 (20130101) A61L 27/3658 (20130101) Original (OR) Class A61L 27/3691 (20130101) A61L 27/3817 (20130101) A61L 27/3856 (20130101) A61L 27/3886 (20130101) A61L 2430/38 (20130101) Compositions of Macromolecular Compounds C08L 5/04 (20130101)
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11596876 — Channeled fibers in separation of biologically active nanoparticles

US 11596876	Marcus et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	CLEMSON UNIVERSITY RESEARCH FOUNDATION (Clemson, South Carolina)
ASSIGNEE(S)	Clemson University Research Foundation (Clemson, South Carolina)
INVENTOR(S)	R. Kenneth Marcus (Clemson, South Carolina); Terri F. Bruce (Clemson, South Carolina); Lei Wang (Clemson, South Carolina); Sisi Huang (Clemson, South Carolina); Tyler Y. Slonecki (Clemson, South Carolina); Rhonda Reigers Powell (Clemson, South Carolina)
ABSTRACT	A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)
FILED	Tuesday, February 05, 2019
APPL NO	16/267579
ART UNIT	1678 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/68 (20130101) Separation B01D 15/327 (20130101) Original (OR) Class Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/262 (20130101) B01J 20/285 (20130101) B01J 20/286 (20130101) B01J 20/28023 (20130101) B01J 2220/54 (20130101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/00 (20130101) C12N 15/10 (20130101) C12N 15/1017 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) G01N 33/5005 (20130101)
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11596909 — System and method for droplet formation and manipulation using ferrofluids

US 11596909	Di Carlo et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Office of Emerging Frontiers and Multidisciplinary Activities (EFMA)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Dino Di Carlo (Los Angeles, California); Soroush Kahkeshani (Los Angeles, California)
ABSTRACT	A microfluidic device for forming droplets includes at least one ferrofluid reservoir disposed in the microfluidic device and containing a ferrofluid therein. The microfluidic device includes a continuous-phase reservoir disposed in the microfluidic device and containing an oil phase therein and one or more microfluidic channels connecting between the at least one ferrofluid reservoir and the continuous-phase reservoir, the continuous-phase reservoir comprising a step region having an increased height as compared to a height of the one or more microfluidic channels. To form droplets an externally applied magnetic field is applied to the device to pull the ferrofluid into the continuous-phase reservoir, whereby droplets are formed at step region.
FILED	Friday, May 29, 2020
APPL NO	16/888563
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 9/0021 (20130101) A61K 9/0024 (20130101) A61K 9/0097 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2037/0023 (20130101) Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 23/411 (20220101) Original (OR) Class B01F 33/30 (20220101) B01F 33/3032 (20220101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 2200/0668 (20130101) B01L 2300/0816 (20130101) B01L 2300/0867 (20130101) B01L 2400/043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/1002 (20130101) G01N 2035/1034 (20130101)
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11597144 — Systems, devices, and methods for fabricating colloidal solids

US 11597144	Hart et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Anastasios John Hart (Waban, Massachusetts); Justin Douglas Beroz (Cambridge, Massachusetts); Alvin Thong Lip Tan (Cambridge, Massachusetts)
ABSTRACT	Disclosed are methods for building colloidal solids by precipitation from a liquid bridge using a needle through which a colloidal particle suspension is dispensed onto a substrate in a temperature-controlled environment. The substrate can rest on a motion-controlled stage, and freeform shapes can be built by coordinating the motion of the stage with the rate of dispense of colloidal particle suspension. Aspects include a scaling law that governs the rate of assembly and a direct-write colloidal assembly process that combines self-assembly with direct-write 3D printing, and can be used to build exemplary freestanding structures using a diverse materials, such as polystyrene, silica and gold particles. Additionally, disclosed are methods for predicting and eliminating cracking by a geometric relationship between particle size and structure dimensions, enabling the production of macroscale, crack-free colloidal crystals.
FILED	Tuesday, January 29, 2019
APPL NO	16/261535
ART UNIT	1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/20 (20170801) B29C 64/106 (20170801) B29C 64/165 (20170801) Original (OR) Class B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 70/00 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 5/22 (20130101)
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11597658 — Preparation of nanosized cubic lithium lanthanum zirconate fast ion conductor via facile polymer-chelate combustion route

US 11597658	Weller et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Jon Mark Weller (Phoenix, Arizona); Candace Chan (Phoenix, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Jon Mark Weller (Phoenix, Arizona); Candace Chan (Phoenix, Arizona)
ABSTRACT	Nanosized cubic lithium lanthanum zirconate is synthesized by forming a solution including an organic compound and compounds of lithium, lanthanum, and zirconium; drying the solution to yield a solid; and heating the solid in the presence of oxygen to pyrolyze the organic compound to yield a product comprising nanosized cubic lithium lanthanum zirconate.
FILED	Friday, December 04, 2020
APPL NO	17/112228
ART UNIT	1761 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/006 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/52 (20130101) C01P 2002/72 (20130101) C01P 2002/74 (20130101) C01P 2002/76 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2006/40 (20130101) C01P 2006/80 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) H01M 10/0562 (20130101) H01M 2300/0071 (20130101)
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11597798 — Porphene, a heterocyclic analog of graphene, methods of making and using the same

US 11597798	Michl et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
ASSIGNEE(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S)	Josef Michl (Boulder, Colorado); Thomas Frank Magnera (Boulder, Colorado)
ABSTRACT	Methods of forming a porphene polymeric material are provided. The resulting material can be a porphene or a metalloporphene polymeric material. The structure of the polymer can be selected based on a material provided in the monomer material. Methods of using the polymeric material are also provided.
FILED	Friday, December 04, 2020
APPL NO	17/112865
ART UNIT	1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/122 (20130101) Original (OR) Class C08G 85/004 (20130101) C08G 2261/40 (20130101) C08G 2261/374 (20130101) C08G 2261/376 (20130101) C08G 2261/3241 (20130101)
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11597945 — Peptides that block transmission of orthotospoviruses and methods of using the same

US 11597945	Tzanetakis et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas)
INVENTOR(S)	Ioannis Tzanetakis (Fayetteville, Arkansas); Jing Zhou (Greenbelt, Maryland)
ABSTRACT	Orthotospovirus virions travel through the thrips foregut and enter midgut epithelial cells through the interaction between virus glycoproteins and cellular receptors with several protein motifs thought to be involved in the interaction. Single, double and triple mutant polypeptides in the soybean vein necrosis virus (SVNV)/Neohydatothrips variabilis system are provided herein and several are shown to block viral transmission from the thrips to the soybean plants. Methods for inhibiting viral transmission using these polypeptides or constructs comprising polynucleotides encoding peptides are also provided herein.
FILED	Friday, June 26, 2020
APPL NO	16/913721
ART UNIT	1662 — Plants
CURRENT CPC	Peptides C07K 7/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8283 (20130101) Original (OR) Class
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11598697 — Air sample collection apparatus and methods for use

US 11598697	Asher
FUNDED BY	National Science Foundation (NSF) National Center for Atmospheric Research (NCAR) Federally Funded Research and Development Center (FFRDC) Operated by University Corporation for Atmospheric Research (UCAR) at Boulder, CO
APPLICANT(S)	University Corporation for Atmospheric Research (Boulder, Colorado)
ASSIGNEE(S)	University Corporation for Atmospheric Research (Boulder, Colorado)
INVENTOR(S)	Elizabeth Asher (Boulder, Colorado)
ABSTRACT	An air sample collection apparatus and methods for operating the air sample collection apparatus are provided. The air sample apparatus comprises a plurality of air canisters comprising at least a first canister and a second canister, a multi-position valve comprising an outlet, and an inlet region, which are fluidly connected to a plurality of ports. Each respective port is fluidly connected to a canister of the plurality of air canisters, a pump operable to provide pressurized sample air to the inlet region of the multi-position valve, and a computing device operable to open and close each respective port fluidly coupled to each canister of the plurality of canisters.
FILED	Wednesday, May 08, 2019
APPL NO	16/406886
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/14 (20130101) G01N 1/22 (20130101) Original (OR) Class G01N 33/0004 (20130101) G01N 2001/021 (20130101) G01N 2001/222 (20130101) G01N 2001/1427 (20130101) G01N 2001/2071 (20130101)
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11599006 — Generation of nested frequency combs in a topological source

US 11599006	Mittal et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Air Force Research Laboratory (AFRL) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)	UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland)
INVENTOR(S)	Sunil Mittal (Rockville, Maryland); Mohammad Hafezi (Washington, District of Columbia)
ABSTRACT	Examples of the present disclosure include the use of a topological system including an array of coupled ring resonators that exhibits topological edge states to generate frequency combs and temporal dissipative Kerr solitons. The topological edge states constitute a travelling-wave super-ring resonator causing generation of at least coherent nested optical frequency combs, and self-formation of nested temporal solitons that are robust against defects in the array at a mode efficiency exceeding 50%.
FILED	Monday, November 01, 2021
APPL NO	17/515757
ART UNIT	2874 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3513 (20130101) Original (OR) Class G02F 1/3536 (20130101) G02F 2203/15 (20130101) G02F 2203/17 (20130101) G02F 2203/54 (20130101) G02F 2203/56 (20130101) Transmission H04B 10/506 (20130101)
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11599020 — Polymer-assisted synthesis of nanoparticles

US 11599020	Mirkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); Pengcheng Chen (Evanston, Illinois); Yuan Liu (Evanston, Illinois); Jingshan Du (Evanston, Illinois)
ABSTRACT	A method of preparing a metal nanoparticle can include depositing an ink on a substrate using nanolithography to form a polymer reactor, wherein the ink comprises at least one metalloporphyrin functionalized polymer comprising a metal ion, porphyrin, and a polyethylene oxide polymer; and thermally annealing the polymer nanoreactor under conditions sufficient to form the nanoparticle. The thermal annealing can include a first stage that includes annealing the polymer nanoreactor at a temperature of about 100° C. to about 350° C. for a time sufficient to aggregate the metal ions in the polymer reactor, and a second stage that includes annealing the aggregated polymer nanoreactor at a temperature of about 500° C. to about 600° C. for a time sufficient to reduce the metal ion and decompose a polymer component of the polymer nanoreactor to thereby form the metal nanoparticle.
FILED	Friday, March 27, 2020
APPL NO	16/832453
ART UNIT	1785 — Miscellaneous Articles, Stock Material
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/48 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/56 (20130101) C08K 2201/011 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/102 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class
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11599022 — Radiation based patterning methods

US 11599022	Stowers et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	Inpria Corporation (Corvallis, Oregon)
ASSIGNEE(S)	Inpria Corporation (Corvallis, Oregon)
INVENTOR(S)	Jason K. Stowers (Corvallis, Oregon); Alan J. Telecky (Albany, Oregon); Douglas A. Keszler (Corvallis, Oregon); Andrew Grenville (Corvallis, Oregon)
ABSTRACT	Stabilized precursor solutions can be used to form radiation inorganic coating materials. The precursor solutions generally comprise metal suboxide cations, peroxide-based ligands and polyatomic anions. Design of the precursor solutions can be performed to achieve a high level of stability of the precursor solutions. The resulting coating materials can be designed for patterning with a selected radiation, such as ultraviolet light, x-ray radiation or electron beam radiation. The radiation patterned coating material can have a high contrast with respect to material properties, such that development of a latent image can be successful to form lines with very low line-width roughness and adjacent structures with a very small pitch.
FILED	Tuesday, June 14, 2022
APPL NO	17/839784
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/20 (20130101) G03F 7/0042 (20130101) G03F 7/0043 (20130101) Original (OR) Class G03F 7/327 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24355 (20150115)
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11599700 — Structural matching for fast re-synthesis of electronic circuits

US 11599700	Possignolo et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF) Division of Computer and Network Systems (CNS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Rafael Possignolo (Santa Cruz, California); Jose Renau (Santa Cruz, California)
ABSTRACT	Techniques include retrieving a first structural netlist (SN1) that indicates electronic components, values of programmable parameters, and connections for a first electronic circuit, and retrieving a first placed and routed netlist (PR1) that indicates physical placement of the electronic components and physical routing of connections for SN1. Also retrieved is a second structural netlist (SN2) for a different second electronic circuit. For each component in SN2, a matching component, if any, is found in SN1 based on type of component and inputs that are output from other matching components. A different second placed and routed netlist (PR2) is generated for the second circuit by deriving new placement and routing for only for non-matching components in SN2.
FILED	Monday, November 30, 2020
APPL NO	17/247085
ART UNIT	2851 — Printing/Measuring and Testing
CURRENT CPC	Electric Digital Data Processing G06F 30/327 (20200101) Original (OR) Class G06F 30/331 (20200101) G06F 30/392 (20200101) G06F 30/396 (20200101) G06F 30/398 (20200101)
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11599798 — Methods of operating a graphics processing unit (GPU) to train a deep neural network using a GPU local memory and related articles of manufacture

US 11599798	Hu et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF) Division of Computer and Network Systems (CNS)
APPLICANT(S)	University of Notre Dame du Lac (South Bend, Indiana)
ASSIGNEE(S)	UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana)
INVENTOR(S)	Xiaobo Sharon Hu (Granger, Indiana); Danny Ziyi Chen (Granger, Indiana); Xiaoming Chen (Beijing, China PRC)
ABSTRACT	A method operating a Graphics Processing Unit (GPU) memory can be provided by accessing specified training parameters used to train a Deep Neural Network (DNN) using a GPU with a local GPU memory, the specified training parameters including at least a specified batch size of samples configured to train the DNN. A sub-batch size of the samples can be defined that is less than or equal to the specified batch size of samples in response to determining that an available size of the local GPU memory is insufficient to store all data associated with training the DNN using one batch of the samples. Instructions configured to train the DNN using the sub-batch size can be defined so that an accuracy of the DNN trained using the sub-batch size is about equal to an accuracy of the DNN trained using the specified batch size of the samples.
FILED	Monday, March 16, 2020
APPL NO	16/819840
ART UNIT	2612 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/10 (20130101) G06N 3/063 (20130101) G06N 3/084 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 1/20 (20130101) G06T 1/60 (20130101)
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11599832 — Systems, circuits and computer program products providing a framework for secured collaborative training using hyper-dimensional vector based data encoding/decoding and related methods

US 11599832	Imani et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Mohsen Imani (San Diego, California); Yeseong Kim (La Jolla, California); Tajana Rosing (San Diego, California); Farinaz Koushanfar (La Jolla, California); Mohammad Sadegh Riazi (Los Angeles, California)
ABSTRACT	A computing system can include a plurality of clients located outside a cloud-based computing environment, where each of the clients may be configured to encode respective original data with a respective unique secret key to generate data hypervectors that encode the original data. A collaborative machine learning system can operate in the cloud-based computing environment and can be operatively coupled to the plurality of clients, where the collaborative machine learning system can be configured to operate on the data hypervectors that encode the original data to train a machine learning model operated by the collaborative machine learning system or to generate an inference from the machine learning model.
FILED	Monday, June 29, 2020
APPL NO	16/915643
ART UNIT	2492 — Cryptography and Security
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 20/20 (20190101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/085 (20130101) H04L 9/0819 (20130101)
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11600481 — Devices and processes for mass spectrometry utilizing vibrating sharp-edge spray ionization

US 11600481	Li et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	West Virginia University (Morgantown, West Virginia)
ASSIGNEE(S)	West Virginia University (Morgantown, West Virginia)
INVENTOR(S)	Peng Li (Morgantown, West Virginia); Xiaojun Li (Morgantown, West Virginia); Stephen J. Valentine (Morgantown, West Virginia); Lisa Holland (Morgantown, West Virginia)
ABSTRACT	In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to a vibrating sharp edge spray ionization (VSSI) method suitable for coupling with a mass spectrometer, a VSSI method modified with a capillary suitable for use with continuous-flow separation methods such as liquid chromatography, and a VSSI method suitable for coupling with a capillary electrophoresis (CE) device in order to introduce the CE sample flow into a mass spectrometer. Also disclosed herein are devices for carrying out these methods and methods of making the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
FILED	Monday, July 13, 2020
APPL NO	16/927936
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/16 (20130101) Original (OR) Class H01J 49/0031 (20130101)
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11601069 — Electrostatic machines that include a malonate in a dielectric fluid

US 11601069	Reitz et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	C-Motive Technologies, Inc. (Middleton, Wisconsin)
ASSIGNEE(S)	C-Motive Technologies, Inc. (Middleton, Wisconsin)
INVENTOR(S)	Graham T. Reitz (Middleton, Wisconsin); William D. Butrymowicz (Middleton, Wisconsin); Justin K Reed (Middleton, Wisconsin); Daniel C. Ludois (Middleton, Wisconsin)
ABSTRACT	An electrostatic machine includes a drive electrode and a stator electrode. The drive electrode and the stator electrode are separated by a gap and form a capacitor. The drive electrode is configured to move with respect to the stator electrode. The electrostatic machine further includes a housing configured to enclose the drive electrode and the stator electrode. The stator electrode is fixed to the housing. The electrostatic machine also includes a dielectric fluid that fills a void defined by the housing, the drive electrode, and the stator electrode. The dielectric fluid includes an ester.
FILED	Monday, August 30, 2021
APPL NO	17/461087
ART UNIT	2834 — Electrical Circuits and Systems
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 69/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/095 (20130101) Dynamo-electric Machines H02K 5/04 (20130101) Electric Machines Not Otherwise Provided for H02N 1/002 (20130101) Original (OR) Class H02N 1/004 (20130101)
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Department of Homeland Security (DHS)

11596613 — Compositions and methods for treating cancer

US 11596613	Schultz et al.
FUNDED BY	Department of Homeland Security (DHS) Countering Weapons of Mass Destruction Office (CWMD) Domestic Nuclear Detection Office (DNDO) National Nuclear Forensics Expertise Development Program (NNFEDP) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
ASSIGNEE(S)	UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
INVENTOR(S)	Michael K. Schultz (Iowa City, Iowa); Somya Kapoor (Iowa City, Iowa); Douglas R. Spitz (Iowa City, Iowa)
ABSTRACT	The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
FILED	Friday, July 31, 2020
APPL NO	16/945327
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/66 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/192 (20130101) A61K 31/437 (20130101) A61K 31/437 (20130101) A61K 31/662 (20130101) A61K 31/662 (20130101) A61K 31/4706 (20130101) A61K 31/4706 (20130101) A61K 39/3955 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 2317/21 (20130101)
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11599617 — Mobile screening vehicle and method for mobile security scanning

US 11599617	McManus et al.
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	Kali McManus (Woodbridge, Virginia); Kristi Harmel (Colorado Springs, Colorado); Gregory Bennett (Colorado Springs, Colorado)
ABSTRACT	Examples are directed toward a system and method relating to mobile screening. For example, a mobile screening vehicle includes a passenger scanner that performs security scanning of a passenger on the mobile screening vehicle. The mobile screening vehicle also includes a verification system that verifies, consistent with the security scanning of passengers, that passengers on the mobile screening vehicle are approved to proceed to a secure area of a travel venue.
FILED	Thursday, April 28, 2022
APPL NO	17/731560
ART UNIT	3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 40/08 (20130101) B60W 60/00253 (20200201) B60W 2540/043 (20200201) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3438 (20130101) G01C 21/3484 (20130101) G01C 21/3617 (20130101) Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class G06F 21/44 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06315 (20130101) G06Q 50/26 (20130101) G06Q 50/30 (20130101) Image or Video Recognition or Understanding G06V 40/40 (20220101)
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11599872 — System and network for access control to real property using mobile identification credential

US 11599872	Lim et al.
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	Jason Lim (Alexandria, Virginia); Daniel Boyd (Arlington, Virginia); Chang Ellison (Arlington, Virginia); William Washington (North Potomac, Maryland); Khailee Marischuk (Smyrna, Georgia)
ABSTRACT	A provider system is connected to one or more readers corresponding to one or more access points. A secure local connection is established between the user device and the provider system via one reader. The provider system receives from the user device a request for user access via one access point corresponding to the one reader, the provider system sends to the user device a request for identification information of the user, and the user device sends user information associated with a first mobile identification credential (MIC) which the user device received from an authorizing party system (APS), the user having consented to release the user information to the provider system, and the user information having been verified. The provider system uses the verified user information associated with the first MIC to verify or not verify the identity of the user before granting or denying the request to the user.
FILED	Tuesday, June 07, 2022
APPL NO	17/834577
ART UNIT	2876 — Optics
CURRENT CPC	Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/326 (20200501) G06Q 20/347 (20130101) Original (OR) Class G06Q 20/3224 (20130101) G06Q 20/3226 (20130101) G06Q 20/3674 (20130101)
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11601816 — Permission-based system and network for access control using mobile identification credential including mobile passport

US 11601816	Lim et al.
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	Jason Lim (Alexandria, Virginia); Daniel Boyd (Arlington, Virginia); Chang Ellison (Arlington, Virginia); William Washington (North Potomac, Maryland)
ABSTRACT	A provider system is connected to readers disposed at distances from the provider system. A secure local connection is established between the client device and the provider system via one of the readers. Before the client reaches an access touchpoint, the provider system receives from the client device a request for client access, the provider system sends to the client device a request for identification information of the client, and the client device sends client information associated with a first mobile identification credential (MIC) which the client device received from an authorizing party system (APS), the client having consented to release the client information to the provider system, and the client information having been verified. The provider system uses the verified client information associated with the first MIC to verify or not verify the identity of the client before granting or denying the request to the client.
FILED	Friday, May 27, 2022
APPL NO	17/827143
ART UNIT	2876 — Optics
CURRENT CPC	Wireless Communication Networks H04W 12/06 (20130101) H04W 12/08 (20130101) H04W 12/71 (20210101) Original (OR) Class
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National Aeronautics and Space Administration (NASA)

11597013 — Low thermal stress engineered metal structures

US 11597013	Sherman et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Powdermet, Inc. (Euclid, Ohio)
ASSIGNEE(S)	POWDERMET, INC. (Euclid, Ohio)
INVENTOR(S)	Andrew Sherman (Mentor, Ohio); Brian Werry (Euclid, Ohio)
ABSTRACT	A structured multi-phase composite which include a metal phase, and a low stiffness, high thermal conductivity phase or encapsulated phase change material, that are arranged to create a composite having high thermal conductivity, having reduced/controlled stiffness, and a low CTE to reduce thermal stresses in the composite when exposed to cyclic thermal loads. The structured multi-phase composite is useful for use in structures such as, but not limited to, high speed engine ducts, exhaust-impinged structures, heat exchangers, electrical boxes, heat sinks, and heat spreaders.
FILED	Tuesday, June 23, 2020
APPL NO	16/909126
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 31/00 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/16 (20130101) B22F 3/1112 (20130101) Original (OR) Class B22F 2003/1106 (20130101) B22F 2998/10 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/16 (20130101) B32B 5/18 (20130101) B32B 5/20 (20130101) Alloys C22C 1/1084 (20130101) C22C 29/14 (20130101) C22C 32/0031 (20130101) C22C 32/0036 (20130101) C22C 32/0078 (20130101) C22C 49/00 (20130101) C22C 49/06 (20130101) C22C 49/11 (20130101)
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11598650 — Integrated multi-mode automation for air traffic control

US 11598650	Sweet
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Architecture Technology Corporation (Minneapolis, Minnesota)
ASSIGNEE(S)	ARCHITECTURE TECHNOLOGY CORPORATION (Minneapolis, Minnesota)
INVENTOR(S)	Douglas Sweet (Campbell, California)
ABSTRACT	Systems, devices, methods, and techniques are described for automated air traffic management using multiple flight operation modes. In one example, a method includes receiving, by a computing device comprising one or more processors, data associated with one or more aircraft in flight in a controlled airspace. The method further includes selecting, by the computing device, based at least in part on the data associated with the one or more aircraft, a respective flight operation mode from among a plurality of flight operation modes for at least one respective aircraft among the one or more aircraft in flight. The method further includes outputting, by the computing device for transmission to the at least one respective aircraft, an indication of the respective flight operation mode selected for the at least one respective aircraft.
FILED	Friday, December 04, 2020
APPL NO	17/112234
ART UNIT	3619 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 23/00 (20130101) Original (OR) Class Traffic Control Systems G08G 5/0013 (20130101) G08G 5/0026 (20130101) G08G 5/0082 (20130101) G08G 5/0091 (20130101) Transmission H04B 7/18506 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11599109 — Mission modeling planning, and execution module (M2PEM) systems and methods

US 11599109	Scrapper et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Information Warfare Center (NIWC) Naval Information Warfare Center Pacific (NIWCPACIFIC) Space and Naval Warfare Systems Center (SPAWAR) National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	Naval Information Warfare Center Pacific (San Diego, California); California Institute Of Technology Jet Propulsion Laboratory (Pasadena, California)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Chris Scrapper (San Diego, California); Greg N Droge (San Diego, California); Alexander L Xydes (San Diego, California); Jean-Pierre de la Croix (Los Angeles, California); Amir Rahmani (Los Angeles, California); Joshua Vander Hook (Los Angeles, California); Grace Lim (Norwalk, California)
ABSTRACT	Methods and systems for accomplishing a mission using a plurality of unmanned vehicles can include graphically describing the mission tasks at a graphical user interface (GUI) using Business Process Model Notation (BPMN), and translating the graphical description into extensible machine language (XML) formatted robot operating system (ROS) instructions, which can be understood by each of the plurality of unmanned vehicles with a translator. An execution engine transmits the XML ROS instructions to a respective local controller on the respective unmanned vehicle. The BPMN graphical descriptor symbols can allow for planning of a mission by an end user that does not have expertise in the ROS domain, and that does not have an understanding of the ROS construct. The execution engine can provide feedback back to the GUI regarding mission execution. Based on the feedback, the graphical description can be modified while the mission is being accomplished.
FILED	Monday, May 06, 2019
APPL NO	16/403838
ART UNIT	3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Systems for Controlling or Regulating Non-electric Variables G05D 1/0016 (20130101) G05D 1/0027 (20130101) Original (OR) Class Electric Digital Data Processing G06F 8/40 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/067 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11600655 — Imaging in curved arrays: methods to produce free-formed curved detectors

US 11600655	Jones et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Todd J. Jones (Altadena, California); Shouleh Nikzad (Valencia, California)
ABSTRACT	A detector including a detector membrane comprising a semiconductor sensor and a readout circuit, the detector membrane having a thickness of 100 micrometers or less and a curved surface conformed to a curved focal plane of an optical system imaging electromagnetic radiation onto the curved surface; and a mount or substrate attached to a backside of the detector membrane. A maximum of the strain experienced by the detector membrane is reduced by distribution of the strain induced by formation of the curved surface across all of the curved surface of the detector membrane, thereby allowing a decreased radius of curvature (more severe curving) as compared to without the distribution.
FILED	Monday, September 21, 2020
APPL NO	17/027495
ART UNIT	2826 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14683 (20130101) H01L 27/14875 (20130101) Original (OR) Class H01L 31/03926 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Agriculture (USDA)

11596677 — Induction of protective immunity against antigens

US 11596677	Curtiss, III et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	University of Florida Research Foundation, Incorporated (Gainsville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Roy Curtiss, III (Gainesville, Florida); Shifeng Wang (Gainesville, Florida)
ABSTRACT	Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens from Clostridium Perfringens as vaccines to prevent necrotic enteritis (NE).
FILED	Friday, August 03, 2018
APPL NO	16/636251
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/08 (20130101) Original (OR) Class A61K 2039/523 (20130101) A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11596963 — In-canopy sprinkler monitoring system for center pivot irrigation systems

US 11596963	Akin et al.
FUNDED BY	Department of Agriculture (USDA) Agricultural Research Service (ARS) Natural Resources Conservation Service (NRCS)
APPLICANT(S)	Kansas State University Research Foundation (Manhattan, Kansas)
ASSIGNEE(S)	Kansas State University Research Foundation (Manhattan, Kansas)
INVENTOR(S)	Aaron Akin (Knoxville, Tennessee); Danny H. Rogers (Manhattan, Kansas); Jonathan Aguilar (Garden City, Kansas)
ABSTRACT	Monitoring systems for center pivot irrigation systems and methods of irrigating an agricultural crop using the irrigation systems are provided. The irrigation systems may comprise a plurality of in-canopy sprinklers. The monitoring systems are configured to detect an operational condition of the plurality of in-canopy sprinklers, including whether individual sprinkler heads have become detached from the irrigation system main line, or whether an individual sprinkler head has become clogged, and alert an operator with a time and/or location of the occurrence of an event associated with one or more of the sprinklers.
FILED	Monday, April 20, 2020
APPL NO	16/852703
ART UNIT	2116 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 25/16 (20130101) A01G 25/092 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 12/008 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

PP035016 — Apple tree rootstock named ‘G.257’

US PP35016	Fazio et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	Cornell University (Ithaca, New York); The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)	Cornell University (Ithaca, New York); The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S)	Gennaro Fazio (Geneva, New York); Terence Lee Robinson (Geneva, New York); Herbert Sanders Aldwinckle (Geneva, New York); James N. Cummins (Alcoa, Tennessee)
ABSTRACT	A new and distinct variety of apple tree rootstock Malus domestica x Malus robusta hybrid ‘G.257’ is described. The new variety is a semi-dwarfing rootstock that is resistant to fire blight (Erwinia amylovora) and crown rot (Phytophthora cactorum) and tolerant to the replant disease complex. The ‘G.257’ rootstock is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees.
FILED	Monday, January 31, 2022
APPL NO	17/589353
ART UNIT	1661 — Plants
CURRENT CPC	Plants PLT/174
VIEW PATENT	@ USPTO: Full Text PDF

Department of Commerce (DOC)

11599798 — Methods of operating a graphics processing unit (GPU) to train a deep neural network using a GPU local memory and related articles of manufacture

US 11599798	Hu et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF) Division of Computer and Network Systems (CNS)
APPLICANT(S)	University of Notre Dame du Lac (South Bend, Indiana)
ASSIGNEE(S)	UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana)
INVENTOR(S)	Xiaobo Sharon Hu (Granger, Indiana); Danny Ziyi Chen (Granger, Indiana); Xiaoming Chen (Beijing, China PRC)
ABSTRACT	A method operating a Graphics Processing Unit (GPU) memory can be provided by accessing specified training parameters used to train a Deep Neural Network (DNN) using a GPU with a local GPU memory, the specified training parameters including at least a specified batch size of samples configured to train the DNN. A sub-batch size of the samples can be defined that is less than or equal to the specified batch size of samples in response to determining that an available size of the local GPU memory is insufficient to store all data associated with training the DNN using one batch of the samples. Instructions configured to train the DNN using the sub-batch size can be defined so that an accuracy of the DNN trained using the sub-batch size is about equal to an accuracy of the DNN trained using the specified batch size of the samples.
FILED	Monday, March 16, 2020
APPL NO	16/819840
ART UNIT	2612 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/10 (20130101) G06N 3/063 (20130101) G06N 3/084 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 1/20 (20130101) G06T 1/60 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Non-Profit Organization (NPO)

11597016 — Efficient bulk unfused powder removal system and method

US 11597016	Hoy et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Non-Profit Organization (NPO) National Center for Manufacturing Sciences Inc. (NCMS)
APPLICANT(S)	3D Systems, Inc. (Rock Hill, South Carolina)
ASSIGNEE(S)	3D SYSTEMS, INC. (Rock Hill, South Carolina)
INVENTOR(S)	Ahren Michael Hoy (Charlotte, North Carolina); Turner Ashby Cathey (Rock Hill, South Carolina); Alexander J Geyling (Fort Mill, South Carolina)
ABSTRACT	An additive manufacturing system for producing a three-dimensional article includes a print engine, a post-fabrication powder removal apparatus, a transport mechanism, and a controller. The post fabrication removal apparatus includes a rotary frame defining an internal receptacle cavity, a plurality of clamps coupled to a corresponding plurality of actuators, a clamping plate coupled to a lift apparatus, and an agitation device mounted to the clamping plate. The controller is configured to perform the following steps: (1) Operate the transport mechanism to transport the build box to the internal receptacle cavity. (2) Operate the plurality of actuators to engage the build box with the plurality of clamps to secure the build box to the rotary frame. (3) Operate the rotary frame to rotate the build box until unfused powder begins to exit the build box. (4) Operate the agitation device to facilitate pouring of the unfused powder from the build box.
FILED	Monday, August 16, 2021
APPL NO	17/402811
ART UNIT	2853 — Printing/Measuring and Testing
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/68 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101)
VIEW PATENT	@ USPTO: Full Text PDF

Small Business Administration (SBA)

11597930 — Targeted inhibition using engineered oligonucleotides

US 11597930	Place et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	miRecule, Inc. (Gaithersburg, Maryland)
ASSIGNEE(S)	MIRECULE, INC. (Gaithersburg, Maryland)
INVENTOR(S)	Robert Place (Gaithersburg, Maryland); Anthony Saleh (Gaithersburg, Maryland); Tishan Williams (Gaithersburg, Maryland)
ABSTRACT	Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.
FILED	Friday, March 11, 2022
APPL NO	17/692644
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, March 07, 2023.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
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You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20230307.html

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