FedInvent™ Patents
Patent Details for Tuesday, April 25, 2023
This page was updated on Tuesday, April 25, 2023 at 05:20 AM GMT
Department of Health and Human Services (HHS)
| US 11632953 | Swale et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Daniel R. Swale (Zachary, Louisiana); Lane D. Foil (Baton Rouge, Louisiana) |
| ABSTRACT | Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or elimination in the ability of the arthropod to feed. Administering Kir channel inhibitors reduces food intake, increases feeding time, reduces salivary gland secretion, induces mortality, and reduces transmission of vector-borne pathogens. Kir channel inhibitors induce these adverse effects in ticks, mosquitoes, horn flies, and aphids. |
| FILED | Monday, November 13, 2017 |
| APPL NO | 16/348236 |
| ART UNIT | 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/38 (20130101) A01N 43/40 (20130101) Original (OR) Class A01N 43/56 (20130101) A01N 43/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633099 | Agichtein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| INVENTOR(S) | Yevgeny E. Agichtein (Atlanta, Georgia); Elizabeth A. Buffalo (Atlanta, Georgia); Dmitry Lagun (Atlanta, Georgia); Cecelia Manzanares (Atlanta, Georgia); Stuart Zola (Atlanta, Georgia) |
| ABSTRACT | Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for diagnosing dementia such as mild cognitive impairment and Alzheimer's disease. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 16/887917 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/113 (20130101) Original (OR) Class A61B 5/165 (20130101) A61B 5/168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633139 | Dudek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | c/o Epitel, Inc. (Salt Lake City, Utah) |
| ASSIGNEE(S) | Epitel, Inc. (Salt Lake City, Utah) |
| INVENTOR(S) | Francis E. Dudek (Salt Lake City, Utah); Michael K. Elwood (Farmington, Utah); John H. Fisher (Cottonwood Heights, Utah); Mark J. Lehmkuhle (Salt Lake City, Utah); Jean M. Wheeler (Salt Lake City, Utah) |
| ABSTRACT | Disclosed systems include a self-contained electroencephalogram (EEG) recording patch comprising a first electrode, a second electrode and wherein the first and second electrodes cooperate to measure a skin-electrode impedance, a substrate containing circuitry for generating an EEG signal from the measured skin-electrode impedance, amplifying the EEG signal, digitizing the EEG signal, and retrievably storing the EGG signal. The patch also comprises a power source and an enclosure that houses the substrate, the power source, and the first and second electrodes in a unitary package. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/860989 |
| ART UNIT | 3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0006 (20130101) A61B 5/291 (20210101) Original (OR) Class A61B 5/316 (20210101) A61B 5/369 (20210101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/4094 (20130101) A61B 5/6814 (20130101) A61B 5/6833 (20130101) A61B 17/3468 (20130101) A61B 2560/0209 (20130101) A61B 2560/0412 (20130101) A61B 2560/0431 (20130101) A61B 2562/164 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633145 | Pogue et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| INVENTOR(S) | Brian Pogue (Hanover, New Hampshire); Samuel Streeter (Encampment, Wyoming); Benjamin Maloney (Princeton, Massachusetts); Keith Paulsen (Hanover, New Hampshire) |
| ABSTRACT | A surgical specimen imaging system includes a micro-X-ray computed tomography (CT) unit for CT imaging of the specimen and a structured light imaging (SLI) unit for optical imaging at multiple wavelengths, multiple phase offsets, and multiple structured-light pattern periods including unstructured light. The system's image processing unit receives CT and optical images and is configured by firmware in memory to co-register the images and process the optical images to determine texture at multiple subimages of the optical images, determined textures forming a texture map. The texture map is processed by a machine-learning-based classifier to determine a tissue type map of the specimen, and the tissue type map is processed with the CT images to give a 3D tissue-type map. In embodiments, the firmware extracts optical properties including scattering and absorption at multiple wavelengths and the classifier also uses these properties in generating the tissue type map. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076788 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4312 (20130101) Original (OR) Class A61B 6/032 (20130101) A61B 6/502 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10081 (20130101) G06T 2207/30068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633146 | Leng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Ethan Yize Leng (Minneapolis, Minnesota); David Henry Porter (Plymouth, Minnesota); Gregory John Metzger (Lake Elmo, Minnesota) |
| ABSTRACT | Medical imaging analysis systems are configured to perform automatic image registration algorithms that perform three-dimensional (3D), affine, and/or intensity-based co-registration of magnetic resonance imaging (MRI) data, such as multiparametric MRI (mpMRT) data, using mutual information (MI) as a similarity metric. An apparatus comprises a computer-readable storage medium storing a plurality of imaging series of magnetic resonance imaging (MRI) data for imaged tissue of a patient; and a processor coupled to the computer-readable storage medium. The processor is configured to receive the imaging series of MRI data; identify a volume of interest (VOI) of each image of the imaging series of MRI data; compute registration parameters for the VOIs through the maximization of mutual information of the corrected VOIs; and register the VOIs using the computed registration parameters. |
| FILED | Friday, January 03, 2020 |
| APPL NO | 16/734139 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4381 (20130101) Original (OR) Class A61B 5/7275 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) G01R 33/5659 (20130101) Image Data Processing or Generation, in General G06T 3/0075 (20130101) G06T 7/0012 (20130101) G06T 7/62 (20170101) G06T 2207/10088 (20130101) G06T 2207/30081 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633152 | Linnes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Jacqueline C Linnes (West Lafayette, Indiana); Benjamin David Walters (Castle Rock, Colorado); Orlando S Hoilett (West Lafayette, Indiana) |
| ABSTRACT | This invention generally relates to methods useful for measuring heart rate, respiration conditions, and oxygen saturation and a wearable device that incorporate those methods with a computerized system supporting data collection, analysis, readout and sharing. Particularly this present invention relates to a wearable device, such as a wristwatch or ring, for real time measuring heart rate, respiration conditions, and oxygen saturation. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/073223 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/0205 (20130101) A61B 5/681 (20130101) Original (OR) Class A61B 5/743 (20130101) A61B 5/0816 (20130101) A61B 5/1112 (20130101) A61B 5/02433 (20130101) A61B 5/4833 (20130101) A61B 5/7207 (20130101) A61B 5/7257 (20130101) A61B 5/14552 (20130101) A61B 2503/12 (20130101) A61B 2560/0214 (20130101) A61B 2560/0228 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633235 | Shekhar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S NATIONAL MEDICAL CENTER (Washington, District of Columbia); IGI TECHNOLOGIES (College Park, Maryland) |
| ASSIGNEE(S) | CHILDREN'S NATIONAL MEDICAL CENTER (Washington, District of Columbia); IGI TECHNOLOGIES (College Park, Maryland) |
| INVENTOR(S) | Raj Shekhar (Washington, District of Columbia); William Plishker (College Park, Maryland); Xinyang Liu (Washington, District of Columbia) |
| ABSTRACT | The present disclosure relates to a tracking system for augmented reality in a clinical setting. Specifically, the present disclosure relates to an approach for combining hardware-based tracking and computer vision-based tracking in order to accurately overlay a projected image onto a video image. |
| FILED | Tuesday, July 31, 2018 |
| APPL NO | 16/634713 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) A61B 34/20 (20160201) Original (OR) Class A61B 2034/107 (20160201) A61B 2034/2051 (20160201) A61B 2034/2055 (20160201) A61B 2034/2065 (20160201) Image Data Processing or Generation, in General G06T 7/74 (20170101) G06T 19/006 (20130101) G06T 2207/20221 (20130101) Image or Video Recognition or Understanding G06V 20/20 (20220101) G06V 2201/03 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633350 | Maisel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Katharina Maisel (College Park, Maryland); Craig W. Hendrix (Baltimore, Maryland); Laura Ensign (Baltimore, Maryland); Edward Fuchs (Baltimore, Maryland); Richard Cone (Baltimore, Maryland); Justin Hanes (Baltimore, Maryland) |
| ABSTRACT | Hypotonic microbicidal compositions including an antimicrobial, such as an antiviral compound, and a pharmaceutically acceptable carrier in a solution formulation having hypotonic osmolarity have been developed for administration rectally to the gastrointestinal mucosa. In a preferred embodiment for use in preventing or decreasing HIV infection, the microbicidal is tenofovir, or a prodrug or derivative thereof. The formulations may include additional agents such as surfactants to enhance cleansing, buffers, or preservatives. Polymers may be included for osmolarity as well as comfort. |
| FILED | Tuesday, December 17, 2019 |
| APPL NO | 16/717570 |
| ART UNIT | 1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/72 (20130101) A61K 8/90 (20130101) A61K 9/06 (20130101) A61K 9/08 (20130101) A61K 9/0012 (20130101) A61K 9/0031 (20130101) Original (OR) Class A61K 9/0034 (20130101) A61K 9/5146 (20130101) A61K 9/5153 (20130101) A61K 31/09 (20130101) A61K 31/09 (20130101) A61K 31/52 (20130101) A61K 31/352 (20130101) A61K 31/365 (20130101) A61K 31/365 (20130101) A61K 31/675 (20130101) A61K 47/10 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633355 | Lee |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Clemson University Research Foundation (Clemson, South Carolina) |
| ASSIGNEE(S) | Clemson University Research Foundation (Clemson, South Carolina) |
| INVENTOR(S) | Jeoung Soo Lee (Clemson, South Carolina) |
| ABSTRACT | Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles. |
| FILED | Wednesday, February 27, 2019 |
| APPL NO | 16/286898 |
| ART UNIT | 1699 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Original (OR) Class A61K 9/5153 (20130101) A61K 31/436 (20130101) A61K 31/436 (20130101) A61K 31/704 (20130101) A61K 31/704 (20130101) A61K 31/713 (20130101) A61K 31/4015 (20130101) A61K 31/4015 (20130101) A61K 45/06 (20130101) A61K 47/593 (20170801) A61K 47/6907 (20170801) A61K 47/6937 (20170801) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) A61P 9/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
11633363 — Fusion proteins having a toxin and cancer marker, nanoparticles, and uses related thereto
| US 11633363 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Lily Yang (Atlanta, Georgia); Xiangxue Guo (Atlanta, Georgia); Hui Mao (Johns Creek, Georgia); Wei Chen (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to nanoparticles coated with fusion proteins comprising a domain that binds a cancer marker and a domain comprising a toxic polypeptide. In certain embodiments, the targeted cancer marker is urokinase plasminogen activator receptor (uPAR) insulin-like growth factor 1 receptor (IGF1R), EGFR, HER2, and/or other member of the ErbB family of receptors. In certain embodiments, the molecule that binds a cancer marker is an amino terminal fragment of uPA or variant capable of binding uPAR and/or IGF1 or variant capable of binding IGF1R. In certain embodiments, the toxic polypeptide is a bacterial exotoxin. |
| FILED | Thursday, September 27, 2018 |
| APPL NO | 16/651699 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 47/6415 (20170801) Peptides C07K 14/65 (20130101) C07K 16/30 (20130101) C07K 16/2863 (20130101) C07K 2319/33 (20130101) C07K 2319/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6462 (20130101) Enzymes C12Y 304/21073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633370 | Roberts, II et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | L. Jackson Roberts, II (Gallatin, Tennessee); Thuy T. Nguyen (Nashville, Tennessee) |
| ABSTRACT | Methods and compounds for use in promoting survival of at least one eukaryotic cell, wherein the compounds are effective as gamma-ketoaldehyde scavengers. |
| FILED | Thursday, July 06, 2017 |
| APPL NO | 16/314851 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/135 (20130101) Original (OR) Class A61K 31/137 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633397 | Pestell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Richard G. Pestell (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard G. Pestell (Philadelphia, Pennsylvania) |
| ABSTRACT | This disclosure is directed, in part, to a method of determining whether a subject having cancer is at risk for developing metastasis of the cancer. In one embodiment, the method comprises (a) obtaining a biological sample from the subject having cancer; (b) determining CCR5 expression level and/or expression level of at least one of CCR5 ligands in the biological sample; and (c) if the expression level of CCR5 and/or of at least one of CCR5 ligands determined in step (b) is increased compared to CCR5 expression level and/or expression level of at least one of CCR5 ligands in a control sample, then the subject is identified as likely at risk for developing metastasis of the cancer. |
| FILED | Monday, March 25, 2019 |
| APPL NO | 16/363981 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/46 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4375 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/57415 (20130101) G01N 33/57484 (20130101) G01N 33/57492 (20130101) G01N 2333/705 (20130101) G01N 2333/7158 (20130101) G01N 2800/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633401 | Ruscetti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Marcus Ruscetti (New York, New York); John P. Morris, IV (New York, New York); Scott Lowe (New York, New York) |
| ABSTRACT | The present technology provides methods for treating pancreatic cancer using a MEK inhibitor and a CDK4/6 inhibitor. Also disclosed herein are methods for increasing patient responsiveness to chemotherapeutic and/or immunotherapeutic regimes for pancreatic cancer. Kits for use in practicing the methods are also provided. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/258054 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/44 (20130101) A61K 31/145 (20130101) A61K 31/185 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/535 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4412 (20130101) A61K 31/4523 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633407 | Quave et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| INVENTOR(S) | Cassandra L. Quave (Atlanta, Georgia); James Lyles (Sandy Springs, Georgia); Gina Porras-Brenes (Atlanta, Georgia); Huaqiao Tang (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357353 |
| ART UNIT | 1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/569 (20130101) Original (OR) Class A61K 31/569 (20130101) A61K 36/22 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633411 | Ernst et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert K. Ernst (Silver Spring, Maryland); Erin M. Harberts (Phoenix, Maryland); Alison J. Scott (Silver Spring, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| INVENTOR(S) | Robert K. Ernst (Silver Spring, Maryland); Erin M. Harberts (Phoenix, Maryland); Alison J. Scott (Silver Spring, Maryland) |
| ABSTRACT | The present invention provides a method of treating sepsis in a subject, comprising administering to the subject an effective amount of a compound of the formula wherein R1 and R2 may be H, OH, protonated phosphate, a phosphate salt, a sugar phosphonate, or a mono-, di- or poly-saccharide, R3 may be OH or a mono-, di- or poly-saccharide, R4, R5, R6 and R7 may be an alkyl or alkenyl chain of up to 13 carbons (for a chain of 16 carbons), and R8, R9, R10 and R11 may be H, OH, or an alkyl or alkenyl ester of up to 16 carbons, or a salt thereof. |
| FILED | Wednesday, October 04, 2017 |
| APPL NO | 16/339313 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/7016 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 31/00 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 13/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633415 | Corsello et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Steven M. Corsello (Boston, Massachusetts); Todd R. Golub (Cambridge, Massachusetts); Eric Stefan (Cambridge, Massachusetts); Robert Hilgraf (Cambridge, Massachusetts) |
| ABSTRACT | The present invention includes CSNK1A1 inhibitors that are useful in treating or preventing a cancer in a subject. In certain embodiments, the cancer comprises a hematological cancer, such as but not limited to acute myeloid leukemia (AML) and/or MDS (myelodysplastic syndrome, including 5q-MDS). In other embodiments, the cancer comprises colon cancer. |
| FILED | Friday, March 30, 2018 |
| APPL NO | 16/498897 |
| ART UNIT | 1616 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/498 (20130101) A61K 31/4439 (20130101) A61K 31/7064 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633418 | Hirano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY (New York, New York) |
| INVENTOR(S) | Michio Hirano (New York, New York); Caterina Garone (Cambridge, United Kingdom) |
| ABSTRACT | The invention relates generally to a pharmacological therapy for a human genetic diseases, specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxyribonucleoside monophosphate, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine monophosphate (dTMP) or deoxycytidine monophosphate (dCMP), or mixtures thereof. This molecular bypass approach is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242862 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/708 (20130101) A61K 31/7068 (20130101) A61K 31/7072 (20130101) Original (OR) Class A61K 31/7076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633423 | Machielse et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mandos LLC (West Hollywood, California) |
| ASSIGNEE(S) | Mandos LLC (West Hollywood, California) |
| INVENTOR(S) | Bernardus Nicolaas Machielse (North Potomac, Maryland); Allan Darling (North Potomac, Maryland) |
| ABSTRACT | This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946670 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 31/724 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633424 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Jian Liu (Chapel Hill, North Carolina); Jine Li (Chapel Hill, North Carolina); Guowei Su (Chapel Hill, North Carolina); Rafal Pawlinski (Chapel Hill, North Carolina); Erica Sparkenbaugh (Chapel Hill, North Carolina) |
| ABSTRACT | Chondroitin sulfate compounds comprising chondroitin sulfate backbone 19 mer, CS-A 19 mer, CS-C 19 mer, CS-E 19 mer, C8 backbone 13 mer, C8-A 13 mer, CS-C 13 mer, CS-E 13 mer and/or combinations thereof are provided. Methods of treating histone toxicity in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the histone toxicity in the subject. Pharmaceutical compositions for use in treating histone toxicity and/or sepsis are provided. Methods of treating sepsis in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the sepsis in the subject. |
| FILED | Wednesday, June 19, 2019 |
| APPL NO | 17/254145 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/737 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633428 | O'Malley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/650640 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633429 | O'Malley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/650645 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633431 | Kaushal |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| INVENTOR(S) | Sunjay Kaushal (Ruxton, Maryland) |
| ABSTRACT | Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191526 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Original (OR) Class A61K 38/19 (20130101) A61K 38/195 (20130101) A61K 38/1833 (20130101) A61K 38/1866 (20130101) A61K 38/1891 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633436 | Kenny et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Douglas Kenny (Cambridge, Massachusetts); Hera Vlamakis (Cambridge, Massachusetts); Ramnik Xavier (Cambridge, Massachusetts); Emily Balskus (Cambridge, Massachusetts); Damian Plichta (Cambridge, Massachusetts) |
| ABSTRACT | Microbes expressing cholesterol oxidoreductase (COR) proteins, methods of engineering the microbes expressing COR proteins, compositions and methods of using the microbes are provided. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/026109 |
| ART UNIT | 1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/575 (20130101) A61K 35/741 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 15/70 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/10 (20130101) C12Q 1/26 (20130101) Enzymes C12Y 101/03006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/902 (20130101) G01N 2800/044 (20130101) G01N 2800/50 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633450 | Tracey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (Great Neck, New York) |
| ASSIGNEE(S) | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (Great Neck, New York) |
| INVENTOR(S) | Kevin J. Tracey (Great Neck, New York); Huan Yang (Manhasset, New York); Yousef Al-Abed (Manhasset, New York) |
| ABSTRACT | Methods of treating HMGB1-mediated inflammation by administering a therapeutically effective amount of an MD2-antagonist to a subject in need thereof are described. The novel MD2 antagonist tetrapeptide P5779 is also described. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/016473 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/215 (20130101) A61K 31/215 (20130101) A61K 31/7024 (20130101) A61K 31/7024 (20130101) A61K 38/07 (20130101) Original (OR) Class A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 5/1016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633457 | Jorcyk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Boise State University (Boise, Idaho) |
| ASSIGNEE(S) | Boise State University (Boise, Idaho) |
| INVENTOR(S) | Cheryl Jorcyk (Boise, Idaho); Don Warner (Boise, Idaho); Matthew David King (Boise, Idaho); Lisa Warner (Boise, Idaho) |
| ABSTRACT | A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, progression, proliferation and metastasis in several cancer types. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 16/846073 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/204 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633458 | Slingluff, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Craig L. Slingluff, Jr. (Charlottesville, Virginia); Ileana S. Mauldin (Charlottesville, Virginia) |
| ABSTRACT | Toll-like receptor (TLR) agonists can induce chemokine production. We find that TLR2 and TLR6 are widely expressed on human melanoma cells, and that TLR2/6 agonists (MALP-2 or FSL-1) synergize with interferon-gamma (IFNγ) to induce production of CXCL10 from melanoma cells. Furthermore, melanoma cells and immune cells freshly isolated from surgical specimens also respond to TLR2/6 agonists +IFNγ by upregulating CXCL10 production, compared to treatment with either agent alone. It is also disclosed herein that these compounds are useful in inducing CLXL10 in other types of cancer. Collectively, these data identify a novel synergy of TLR2/6 agonists +IFNγ for inducing CXCL10 production directly from melanoma cells, raising the possibility that intratumoral administration of these agents may improve immune signatures in melanoma and have value in combination with other immune therapies, by supporting T-cell migration into melanoma metastases. |
| FILED | Friday, November 07, 2014 |
| APPL NO | 15/035015 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 31/352 (20130101) A61K 31/352 (20130101) A61K 31/353 (20130101) A61K 31/353 (20130101) A61K 31/7084 (20130101) A61K 31/7084 (20130101) A61K 38/08 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/217 (20130101) Original (OR) Class A61K 38/217 (20130101) A61K 45/06 (20130101) A61K 47/12 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633464 | Vujanovic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Nikola L. Vujanovic (Pittsburgh, Pennsylvania); Lazar Vujanovic (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods are disclosed for inhibiting the development of a tumor in a subject. The methods include administering to a subject a therapeutically effective amount of a dominant negative tumor necrosis factor (DN-TNF)-α protein and/or a nucleic acid encoding the DN-TNF-α protein. The DN-TNF-α protein and/or a nucleic acid encoding the DN-TNF-α protein can be administered alone or in combination with other agents. |
| FILED | Tuesday, November 19, 2019 |
| APPL NO | 16/688930 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2013 (20130101) A61K 38/2046 (20130101) A61K 38/2086 (20130101) A61K 39/00114 (20180801) A61K 39/001117 (20180801) Original (OR) Class A61K 39/001139 (20180801) A61K 45/06 (20130101) A61K 2039/57 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633470 | Amanna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Najít Technologies, Inc. (Beaverton, Oregon) |
| ASSIGNEE(S) | Najit Technologies, Inc. (Beaverton, Oregon) |
| INVENTOR(S) | Ian J. Amanna (Hillsboro, Oregon); Elizabeth A. Poore (Portland, Oregon) |
| ABSTRACT | Provided are surprisingly effective methods for inactivating pathogens, and for producing highly immunogenic vaccine compositions containing an inactivated pathogen rendered noninfectious by exposure to a Fenton reagent, or by exposure to a Fenton reagent or a component thereof in combination with a methisazone reagent selected from the group consisting of methisazone, methisazone analogs, functional group(s)/substructure(s) of methisazone, and combinations thereof. The methods efficiently inactivate pathogens, while substantially retaining pathogen antigenicity and/or immunogenicity, and are suitable for inactivating pathogens, or for the preparation of vaccines for a wide variety of pathogens with genomes comprising RNA or DNA, including viruses and bacteria. Also provided are highly immunogenic inactivated vaccine compositions prepared by using any of the disclosed methods, and methods for eliciting an immune response in a subject by administering such vaccine compositions. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497810 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/40 (20130101) A61K 39/02 (20130101) A61K 39/12 (20130101) A61K 39/105 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 39/275 (20130101) A61K 39/0283 (20130101) A61K 2039/521 (20130101) A61K 2039/5252 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16131 (20130101) C12N 2760/16134 (20130101) C12N 2760/16163 (20130101) C12N 2760/16171 (20130101) C12N 2770/24134 (20130101) C12N 2770/24163 (20130101) C12N 2770/24171 (20130101) C12N 2770/36134 (20130101) C12N 2770/36163 (20130101) C12N 2770/36171 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633471 | Chackerian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico); The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); Bryce Chackerian (Albuquerque, New Mexico); Alan Remaley (Bethesda, Maryland); Marcelo Amar (Bethesda, Maryland); Alexandra Fowler (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico); The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Bryce Chackerian (Albuquerque, New Mexico); Alan Remaley (Bethesda, Maryland); Marcelo Amar (Bethesda, Maryland); Alexandra Fowler (Albuquerque, New Mexico) |
| ABSTRACT | An immunogen generally includes a virus-like particle and an antigen linked to the virus-like particle. The antigen includes an antigenic portion of a polypeptide, wherein the polypeptide inhibits lipoprotein lipase (LPL) activity by binding to LPL. In some embodiments, the polypeptide is at least a portion of angiopoietin-like 3 (ANGPTL3). In other embodiments, the polypeptide is at least a portion of angiopoietin-like 4 (ANGPTL4). In other embodiments, the polypeptide at least a portion of angiopoietin-like 8 (ANGPTL8). In some embodiments, the virus-like particle is a Qbeta immunogenic carrier. In some of these embodiments, the antigen is linked to the virus-like particle through a Gly-Gly-Gly-Cys linker at the C-terminal of the antigen. |
| FILED | Wednesday, March 06, 2019 |
| APPL NO | 16/977648 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0012 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/6901 (20170801) A61K 2039/5258 (20130101) A61K 2039/6075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2795/18122 (20130101) C12N 2795/18123 (20130101) C12N 2795/18133 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633473 | Levy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Ofer Levy (Cambridge, Massachusetts); David J. Dowling (Brighton, Massachusetts); Francesco Borriello (Jamaica Plain, Massachusetts); Carlo Pietrasanta (Boston, Massachusetts) |
| ABSTRACT | Provided herein are Stimulator of Interferon Genes (STING) ligand for use in enhancing immune response and/or as adjuvants in vaccines. In some embodiments, STING ligand is used alone or in combination with Alum in an adjuventation system for early life immunization. |
| FILED | Tuesday, November 27, 2018 |
| APPL NO | 16/766902 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 39/145 (20130101) A61K 2039/55 (20130101) A61K 2039/545 (20130101) A61K 2039/55505 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633502 | Pillarsetty et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Naga Vara Kishore Pillarsetty (Jackson Heights, New York); Steven M. Larson (New York, New York); Sang-gyu Lee (New York, New York) |
| ABSTRACT | Described herein are liposome-based nanocarriers that selectively target bone marrow, minimize tumor delivery, and maintain high drug concentrations in bone marrow when compared to conventional systemic delivery. The composition of the liposome-based nanocarriers may also be tuned to selectively target lymph nodes and other reticuloendothelial system organs (e.g., spleen, e.g., liver). Also described herein are methods of imaging and mapping the bone marrow and/or other reticuloendothelial system organs using the described liposome-based nanocarriers. These methods provide high resolution non-invasive and quantitative imaging via PET, which offers advantages over conventional imaging/tracking methods. Furthermore, in certain embodiments, the liposome-based carriers are used to stabilize and deliver radioprotectant/free radical scavenger drugs to the bone marrow, thereby protecting the bone marrow from subsequent radiation exposure, thereby limiting the adverse impact of radiation exposure on the individual. |
| FILED | Tuesday, March 07, 2017 |
| APPL NO | 16/080823 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/50 (20170801) A61K 47/60 (20170801) A61K 47/547 (20170801) A61K 47/6911 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633503 | Mirkin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Amy S. Paller (Wilmette, Illinois); David A. Giljohann (Chicago, Illinois) |
| ABSTRACT | The present invention relates to compositions and methods for delivering an oligonucleotide-functionalized nanoparticle. |
| FILED | Monday, October 15, 2018 |
| APPL NO | 16/160196 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/5094 (20130101) A61K 31/00 (20130101) A61K 47/52 (20170801) A61K 47/6923 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633504 | Doering et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia); CHILDREN'S HEALTHCARE OF ATLANTA, INC. (Atlanta, Georgia); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | EMORY UNIVERSITY (Atlanta, Georgia); CHILDREN'S HEALTHCARE OF ATLANTA, INC. (Atlanta, Georgia); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| INVENTOR(S) | Christopher Doering (Atlanta, Georgia); Harold Trent Spencer (Atlanta, Georgia); Eric Gaucher (Atlanta, Georgia); Caelan Radford (Powder Springs, Georgia) |
| ABSTRACT | Disclosed herein are novel variants of clotting factors VII, VIII, and IX and their use, for example, in methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B. |
| FILED | Wednesday, May 09, 2018 |
| APPL NO | 16/612167 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) Peptides C07K 14/755 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/644 (20130101) C12N 9/6437 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633506 | Weichert et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| INVENTOR(S) | Jamey Weichert (Sun Prairie, Wisconsin); Paul Sondel (Madison, Wisconsin); Ravi Patel (Madison, Wisconsin); Zachary Morris (Madison, Wisconsin); Peter Carlson (Madison, Wisconsin); Reinier Hernandez (Madison, Wisconsin); Joseph Grudzinski (Madison, Wisconsin) |
| ABSTRACT | The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid ether metal chelate, a radiohalogenated phospholipid ether, or other targeted radiotherapy (TRT) agent that is differentially retained within malignant solid tumor tissue, and either (a) performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or (b) performing immunotherapy in the subject by systemically administering to the subject an immunostimulatory agent, such as an immune checkpoint inhibitor. In a non-limiting example, the radioactive phospholipid ether metal chelate or radiohalogenated phospholipid ether has the formula: wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half-life of greater than 6 hours and less than 30 days, or wherein R1 comprises a radioactive halogen isotope. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3. |
| FILED | Friday, November 10, 2017 |
| APPL NO | 15/809427 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/2013 (20130101) A61K 39/39541 (20130101) A61K 39/39541 (20130101) A61K 39/39558 (20130101) A61K 41/0038 (20130101) A61K 51/0408 (20130101) A61K 51/0485 (20130101) Original (OR) Class A61K 51/0489 (20130101) A61K 51/0497 (20130101) A61K 51/1045 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) A61N 5/1001 (20130101) A61N 2005/1021 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) A61P 37/04 (20180101) Peptides C07K 14/52 (20130101) C07K 16/2818 (20130101) C07K 16/3084 (20130101) C07K 2319/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633535 | Damiano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BETA BIONICS, Inc. (Concord, Massachusetts) |
| ASSIGNEE(S) | BETA BIONICS, Inc. (Concord, Massachusetts) |
| INVENTOR(S) | Edward R. Damiano (Acton, Massachusetts); David Matthew Henderson (Mission Viejo, California); Bryan Dale Knodel (Flagstaff, Arizona); Michael J. Rosinko (Anaheim, California) |
| ABSTRACT | Certain embodiments provide multi-medicament or single medicament infusion systems for preventing the cross-channeling or improper delivery of medicaments. The system may include one or more of an infusion pump, medicament cartridges, cartridge connectors, a multi-channel fluid conduit, and an infusion set. The medicament cartridges may be sized and shaped differently such that the medicament reservoirs can only be inserted into the pump under selected configurations. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/038949 |
| ART UNIT | 3783 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/158 (20130101) A61M 5/162 (20130101) A61M 5/1407 (20130101) Original (OR) Class A61M 5/14244 (20130101) A61M 5/14248 (20130101) A61M 39/105 (20130101) A61M 2005/1587 (20130101) A61M 2205/13 (20130101) A61M 2205/505 (20130101) A61M 2205/584 (20130101) A61M 2205/3317 (20130101) A61M 2205/8206 (20130101) A61M 2205/8243 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633606 | Kass et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | David Kass (Columbia, Maryland); Gordon Tomaselli (Lutherville, Maryland); Jonathan Kirk (Baltimore, Maryland) |
| ABSTRACT | The invention provides methods related to improving heart function. |
| FILED | Tuesday, November 19, 2019 |
| APPL NO | 16/688651 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/365 (20130101) A61N 1/3627 (20130101) Original (OR) Class A61N 1/3682 (20130101) A61N 1/3684 (20130101) A61N 1/3688 (20130101) A61N 1/36507 (20130101) A61N 1/36843 (20170801) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/447 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633622 | Dong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pulsethera, Inc. (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | Pulsethera, Inc. (Chestnut Hill, Massachusetts) |
| INVENTOR(S) | Pu-Ting Dong (Boston, Massachusetts); Jie Hui (Boston, Massachusetts); Ji-Xin Cheng (Newton, Massachusetts); Yifan Zhu (Allston, Massachusetts) |
| ABSTRACT | Methods of the present invention comprise photoinactivation of catalase in combination with low-concentration peroxide solutions and/or ROS generating agents to provide antibacterial effects. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/685897 |
| ART UNIT | 1799 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/40 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/10 (20130101) A61L 2/208 (20130101) A61L 2101/02 (20200801) A61L 2202/26 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 5/0616 (20130101) A61N 5/0624 (20130101) A61N 2005/0635 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633623 | Sawant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Of Maryland, Baltimore (Baltimore, Maryland); The Board of Regents of the University of Texas System (Austin, Texas); Broncus Medical Inc. (San Jose, California) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland); The Board of Regents of the University of Texas System (Austin, Texas); Broncus (San Jose, California) |
| INVENTOR(S) | Amit Sawant (Columbia, Maryland); Robert Timmerman (Westlake, Texas); Yulong Yan (Plano, Texas); Henky Wibowo (San Jose, California); Esther Vicente (Baltimore, Maryland); Arezoo Modiri (Rosedale, Maryland) |
| ABSTRACT | A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels. |
| FILED | Monday, April 20, 2020 |
| APPL NO | 16/853304 |
| ART UNIT | 2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1031 (20130101) Original (OR) Class A61N 5/1039 (20130101) A61N 5/1045 (20130101) A61N 5/1064 (20130101) A61N 5/1077 (20130101) A61N 2005/1055 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/10076 (20130101) G06T 2207/10088 (20130101) G06T 2207/30061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633627 | Krishnaswamy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire); DOSEOPTICS, LLC (Lebanon, New Hampshire) |
| ASSIGNEE(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire); DOSEOPTICS, LLC (Lebanon, New Hampshire) |
| INVENTOR(S) | Venkataramanan Krishnaswamy (Lebanon, New Hampshire); Petr Bruza, Jr. (Lebanon, New Hampshire); Michael Jermyn (Lebanon, New Hampshire); Brian W. Pogue (Hanover, New Hampshire); David Gladstone (Norwich, Vermont); Lesley A. Jarvis (Hanover, New Hampshire); Irwin Tendler (Hanover, New Hampshire) |
| ABSTRACT | A Cherenkov-based or thin-sheet scintillator-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light or scintillator-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov light or scintillator light imaging. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313838 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1045 (20130101) A61N 5/1049 (20130101) A61N 5/1071 (20130101) Original (OR) Class A61N 5/1081 (20130101) A61N 2005/1054 (20130101) A61N 2005/1059 (20130101) Measurement of Nuclear or X-radiation G01T 1/22 (20130101) G01T 1/2002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633732 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Omar Abudayyeh (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein is a lateral flow diagnostic device and methods of using thereof. The device comprises a substrate and a first end, wherein the first end comprises a sample loading portion. The first end may further comprise a first region loaded with a detectable ligand, a CRISPR effector system, a detection construct, a first test band comprising a biotin ligand, and a second test band comprising a capture molecule for the detectable ligand. The detection construct may comprise an RNA oligonucleotide, having a first molecule such as FITC on a first end and a second molecule such as FAM on a second end. Contacting the sample loading portion with a sample causes the sample to flow from the sample loading portion of the substrate towards the first and second capture regions, thereby generating a detectable signal, which may be indicative of a disease state. |
| FILED | Thursday, October 04, 2018 |
| APPL NO | 16/753896 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/126 (20130101) B01L 2300/0819 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/6816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633879 | Stoeckl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); The Trustees Of The University Of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Brendan D. Stoeckl (Philadelphia, Pennsylvania); Robert L. Mauck (Philadelphia, Pennsylvania); Hannah Zlotnick (Philadelphia, Pennsylvania); Megan Farrell (Philadelphia, Pennsylvania); Liane Miller (Philadelphia, Pennsylvania); David Steinberg (Philadelphia, Pennsylvania) |
| ABSTRACT | A method for forming a prosthesis comprising a bone-like portion and a cartilage-like portion can comprise additively manufacturing a first positive mold in accordance with a portion of a first three-dimensional model of a portion of a bone. A first negative mold can be formed from the first positive mold. The bone-like portion can be created within the first negative mold. A second positive mold of the bone and a cartilage can be additively manufactured from a second three-dimensional model. A portion of the second three-dimensional model can correspond to a portion of the first three-dimensional model. A second negative mold can be formed from the second positive mold. The bone-like portion can be positioned in the second negative mold so that the second negative mold and the bone-like portion can define a cartilage space that can be filled with a material to form the cartilage-like portion of the prosthesis. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152647 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/4261 (20130101) A61F 2/30942 (20130101) A61F 2002/4271 (20130101) A61F 2002/30948 (20130101) A61F 2002/30952 (20130101) A61F 2002/30953 (20130101) A61F 2002/30957 (20130101) A61F 2002/30985 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/26 (20130101) A61L 27/52 (20130101) A61L 2430/02 (20130101) A61L 2430/06 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/3842 (20130101) Original (OR) Class B29C 64/386 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2067/04 (20130101) B29K 2105/0061 (20130101) B29K 2883/00 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7532 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634381 | Passaniti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United States of America as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United States of America as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Antonino Passaniti (White Hall, Maryland); Alexander D. MacKerell, Jr. (Baltimore, Maryland) |
| ABSTRACT | Provide herein are compounds with a general chemical structure of: Substituents R1 and R2 independently are H, Cl, F, Br, CH3, CF3, SH, —N(C1-3alkyl)2, —NHC(O)C1-3alkyl, or —NHC(O)C5-7cycloalkyl, substituent R3 is H or C1-3 alkyl and R4 is a bridged cycloalkene such as a bridged cyclohexene or a bridge-substituted cyclohexene. The compounds are therapeutics to treat a cancer, such as breast cancer, or metastatic cancers, to inhibit RUNX2 activity, such as protein expression, in a cancer cell and to increase survival of a subject with breast cancer. |
| FILED | Friday, May 03, 2019 |
| APPL NO | 16/402402 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/196 (20130101) A61K 31/196 (20130101) A61K 31/517 (20130101) A61K 31/517 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 235/82 (20130101) Original (OR) Class C07C 2601/14 (20170501) C07C 2602/42 (20170501) C07C 2603/94 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634396 | Medina et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Epiodyne, Inc. (San Francisco, California) |
| ASSIGNEE(S) | EPIODYNE, INC. (San Francisco, California) |
| INVENTOR(S) | Julio Cesar Medina (South San Francisco, California); Alok Nerurkar (San Diego, California); Corinne Sadlowski (London, United Kingdom); Frederick Seidl (San Mateo, California); Heng Cheng (Fremont, California); Jason Duquette (Millbrae, California); John Lee (Pacifica, California); Martin Holan (Stamford, Connecticut); Pingyu Ding (Foster City, California); Xiaodong Wang (South San Francisco, California); Tien Widjaja (Lafayette, Colorado); Thomas Nguyen (Newbury Park, California); Ulhas Bhatt (Fremont, California); Yihong Li (South San Francisco, California); Zhi-liang Wei (Foster City, California) |
| ABSTRACT | Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/714030 |
| ART UNIT | 1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 233/65 (20130101) Heterocyclic Compounds C07D 213/56 (20130101) C07D 239/26 (20130101) C07D 263/58 (20130101) C07D 277/30 (20130101) Original (OR) Class C07D 295/155 (20130101) C07D 307/54 (20130101) C07D 333/24 (20130101) C07D 401/12 (20130101) C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634400 | Fasan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Rudi Fasan (Rochester, New York); Simone Giovani (Grosseto, Italy); Hanan Alwaseem (Dearborn, Michigan) |
| ABSTRACT | The present invention relates to derivatives of the sesquiterpene lactone micheliolide, methods and compositions for their preparation, and methods for using the micheliolide derivatives in pharmaceutical compositions as anticancer and anti-inflammatory agents. The invention also relates to methods for producing micheliolide derivatives modified at positions C2 and C14. The invention also relates to methods for producing parthenolide derivatives modified at positions C2 and C14 in conjunction with modifications at position C13, via chemoenzymatic methods. The invention further relates to methods for using parthenolide derivatives for treating cancer and inflammatory diseases. |
| FILED | Friday, August 17, 2018 |
| APPL NO | 16/640138 |
| ART UNIT | 1699 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Heterocyclic Compounds C07D 307/93 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0081 (20130101) Enzymes C12Y 114/15006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634404 | Sibley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); The University of Kansas (Lawrence, Kansas); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland); THE UNIVERSITY OF KANSAS (Lawrence, Kansas); THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| INVENTOR(S) | David R. Sibley (Bethesda, Maryland); Amy Elizabeth Moritz (Bethesda, Maryland); R. Benjamin Free (Bethesda, Maryland); Joseph P. Steiner (Bethesda, Maryland); Noel Terrence Southall (Rockville, Maryland); Marc Ferrer (Rockville, Maryland); Xin Hu (Rockville, Maryland); Warren S. Weiner (Boston, Massachusetts); Jeffrey Aubé (Chapel Hill, North Carolina); Kevin Frankowski (Chapel Hill, North Carolina) |
| ABSTRACT | The disclosure of a compound of Formula (I) or a pharmaceutically acceptable salt thereof (I) The variables W, R1, R2, R3, and R4 are defined in the disclosure. The disclosure provides a compound or salt of Formula (I) together with a pharmaceutically acceptable carrier. The disclosure also provides methods of treating a patient for Parkinson's disease and related syndromes, dyskinesia, especially dyskinesias secondary to treating Parkinson's disease with L-DOPA, neurodegenerative disorders such as Alzheimer's disease and dementia, Huntington's disease, restless legs syndrome, bipolar disorder and depression, schizophrenia, cognitive dysfunction, or substance use disorders, the methods comprising administering a compound of Formula I or salt thereof to the patient. The disclosure provides combination methods of treatment in which the compound of Formula (I) is administered to the patient together with one or more additional active agents. |
| FILED | Friday, April 14, 2017 |
| APPL NO | 16/093365 |
| ART UNIT | 1699 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 209/42 (20130101) C07D 213/65 (20130101) C07D 213/81 (20130101) C07D 235/24 (20130101) C07D 295/185 (20130101) C07D 307/85 (20130101) C07D 317/64 (20130101) C07D 333/70 (20130101) C07D 401/12 (20130101) Original (OR) Class C07D 405/12 (20130101) C07D 409/12 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634450 | Qi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Jun Qi (Sharon, Massachusetts); Scott Armstrong (Mayland, Massachusetts); Paul M. Park (Waltham, Massachusetts) |
| ABSTRACT | Provided herein are bifunctional compounds with a moiety (e.g., lenalidomide, thalidomide) that is a binder of an E3 ubiquitin ligase (e.g., Cereblon) and another moiety that is a binder of a target protein DOT1L to induce degradation of DOT1L. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers). Provided also are methods of inducing the degradation of DOT1L by administering a bifunctional compound or composition described herein, wherein one component of the bifunctional compound is a binder of an E3 ubiquitin ligase (e.g., lenalidomide, thalidomide) and another component of the compound is a binder of the target protein DOT1L in a subject. |
| FILED | Thursday, June 27, 2019 |
| APPL NO | 17/252842 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634451 | Romesberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| INVENTOR(S) | Floyd E. Romesberg (La Jolla, California); Denis A. Malyshev (Solana Beach, California); Lingjun Li (San Diego, California); Thomas Lavergne (La Versoud, France); Zhengtao Li (Pudong new district, China PRC) |
| ABSTRACT | Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker. |
| FILED | Monday, July 22, 2019 |
| APPL NO | 16/518715 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/00 (20130101) C07H 19/24 (20130101) Original (OR) Class C07H 21/00 (20130101) C07H 21/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/1024 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6832 (20130101) C12Q 1/6832 (20130101) C12Q 2525/117 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634459 | Kinney |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Claire Y. Kinney (Fort Collins, Colorado) |
| ABSTRACT | Chimeric flaviviruses engineered to contain a reporter gene and chimeric nucleic acid molecules encoding the chimeric flaviviruses are described. The chimeric flaviviruses further include genomic non-coding regions, non-structural proteins, and at least a portion of a capsid (C) protein from West Nile virus (WNV), and premembrane (prM) and envelope (E) proteins from dengue virus (DENV). Diagnostic assays that utilize chimeric West Nile/dengue viruses are further described. |
| FILED | Friday, August 17, 2018 |
| APPL NO | 16/639652 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 14/1825 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24122 (20130101) C12N 2770/24141 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634466 | Zingman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | University Of Iowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Leonid Zingman (Iowa City, Iowa); Denice Hodgson-Zingman (Iowa City, Iowa) |
| ABSTRACT | In certain embodiments, the present invention provides a musclin peptide and methods of increasing muscle growth, performance, resistance to injury and/or preventing or reducing muscle atrophy and improving overall skeletal muscle, metabolic and cardiac health in an animal in need thereof by administering a musclin peptide. |
| FILED | Thursday, May 16, 2019 |
| APPL NO | 16/414263 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/19 (20130101) A61K 38/27 (20130101) A61K 38/2242 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Peptides C07K 14/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634469 | Russell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Stephen James Russell (Rochester, Minnesota); Shruthi Naik (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding VSV polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/916482 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/766 (20130101) A61K 38/215 (20130101) A61K 48/005 (20130101) Peptides C07K 14/565 (20130101) C07K 14/705 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/20232 (20130101) C12N 2760/20243 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634471 | Jin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Moonsoo Jin (New York, New York) |
| ABSTRACT | The present invention is directed to transduced T cells expressing at least 100,000 molecules of human somatostatin receptor 2 (SSTR2), which improves PET/CT imaging sensitivity. The present invention is also directed to transduced T cells expressing SSTR2 and chimeric antigen receptor (CAR). In one embodiment, the CAR is specific to human ICAM-1 and the CAR comprises a binding domain that is scFv of anti-human ICAM-1, or an I domain of the αL subunit of human lymphocyte function-associated antigen-1. In another embodiment, the CAR is specific to human CD19, and the CAR comprises a binding domain that is scFv of anti-human CD19. The present invention is further directed to using the above transduced T cells for monitoring T cell distribution in a patient by PET/CT imaging and/or treating cancer. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 16/787539 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/1796 (20130101) A61K 39/0011 (20130101) A61K 39/001166 (20180801) A61K 51/083 (20130101) A61K 51/088 (20130101) A61K 2039/54 (20130101) A61K 2039/515 (20130101) Peptides C07K 14/723 (20130101) Original (OR) Class C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70553 (20130101) C07K 2319/03 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634477 | Nussenzweig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Michel Nussenzweig (New York, New York); Davide F. Robbiani (New York, New York) |
| ABSTRACT | This disclosure provides novel broadly neutralizing anti-SARS-CoV-2 antibodies or antigen-binding fragments thereof. The disclosed anti-SARS-CoV-2 antibodies constitute a novel therapeutic strategy in protection from SARS-CoV-2 infections. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242583 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/33 (20130101) C07K 2317/35 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634478 | Scheid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York); California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Johannes Scheid (New York, New York); Michel Nussenzweig (New York, New York); Pamela J. Bjorkman (Altadena, California); Ron Diskin (Rehovot, Israel) |
| ABSTRACT | The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/248143 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/1045 (20130101) Original (OR) Class C07K 16/1063 (20130101) C07K 2317/10 (20130101) C07K 2317/21 (20130101) C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634491 | Diaz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Luis Diaz (Ellicot City, Maryland); Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Dung Le (Lutherville, Maryland); Drew M. Pardoll (Brookville, Maryland); Suzanne L. Topalian (Brookville, Maryland) |
| ABSTRACT | Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/739278 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/55 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/30 (20130101) C07K 16/40 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/00 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 113/11052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634507 | Mao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| INVENTOR(S) | Chuanbin Mao (Norman, Oklahoma); Lin Wang (Norman, Oklahoma); Penghe Qiu (Norman, Oklahoma) |
| ABSTRACT | A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide. |
| FILED | Thursday, April 02, 2020 |
| APPL NO | 16/838798 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/39 (20130101) A61K 39/385 (20130101) A61K 2039/60 (20130101) A61K 2039/627 (20130101) A61K 2039/645 (20130101) A61K 2039/55561 (20130101) Peptides C07K 17/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634676 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Charles James Baker (Cambridge, Massachusetts); Ghee Chuan Lai (Cambridge, Massachusetts); Dirk Landgraf (Cambridge, Massachusetts); Burak Okumus (Cambridge, Massachusetts); Johan Paulsson (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are methods inducing the uptake of an agent by a cell. Aspects of the invention relate to physically compressing the cell to induce perturbations (e.g., holes) in the cell membrane or wall. An agent is taken up by the cell through induced perturbations. |
| FILED | Wednesday, July 18, 2018 |
| APPL NO | 16/631532 |
| ART UNIT | 1799 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502776 (20130101) B01L 2200/027 (20130101) B01L 2400/082 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 35/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634691 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | David V. Schaffer (Danville, California); Melissa A. Kotterman (Berkeley, California); Bum-Yeol Hwang (Moraga, California); James T. Koerber (San Francisco, California) |
| ABSTRACT | The present disclosure provides infectious recombinant adeno-associated virus (rAAV) virions that comprise a variant capsid protein and a heterologous nucleic acid. The present disclosure further provides the variant adeno-associated virus (AAV) capsid proteins (and/or a nucleic acid encoding the variant AAV capsid proteins), which confer to an infectious rAAV virion an increased resistance to human AAV neutralizing antibodies. The present disclosure further provides host cells comprising an infectious rAAV virion and/or a nucleic acid encoding a subject variant AAV capsid protein. The present disclosure further provides methods of delivering a heterologous nucleic acid to a target cell where the target cell is contacted with a subject infectious rAAV virion. The present disclosure further provides methods of delivering a gene product to an individual, the methods generally involving administering an effective amount of a subject rAAV virion to an individual in need thereof. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725289 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) Peptides C07K 14/001 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0686 (20130101) C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634699 | Clubb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Robert T. Clubb (Culver City, California); Brendan Rayhan Amer (Los Angeles, California); Janine Y. Fu (Rancho Palos Verdes, California); Scott McConnell (Los Angeles, California); Hung Ton-That (Manvel, Texas); Chungyu Chang (Seabrook, Texas) |
| ABSTRACT | Covalently cross-linked pilus polymers displayed on the cell surface of Gram-positive bacteria are assembled by class C sortase enzymes. These pilus-specific transpeptidases located on the bacterial membrane catalyze a two-step protein ligation reaction—first, cleaving the LPXTG motif of one pilin protomer to form an acyl-enzyme intermediate, and second, joining the terminal threonine to the nucleophilic lysine residue residing within the pilin motif of another pilin protomer. Informed by the high-resolution crystal structures of corynebacterial pilus-specific sortase (SrtA) and by developing structural variants of the sortase enzyme whose catalytic pocket has been unmasked by activating mutations, we have developed new reagents capable of forming isopeptide bonds in vitro. The reagents disclosed herein can catalyze ligation of isolated SpaA domains in vitro provide a facile and versatile new platform for protein engineering and bio-conjugation that has major implications for biotechnology. |
| FILED | Wednesday, May 01, 2019 |
| APPL NO | 17/052116 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 1/13 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634700 | Kohli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Rahul Kohli (Penn Valley, Pennsylvania); Emily Schutsky (Philadelphia, Pennsylvania); Monica Yun Liu (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention includes mutant AID, APOBEC, and Tet enzymes with improved functions. In one aspect the invention provides APOBEC fusion proteins comprising hyperactive deamination activity. In another aspect, the invention provides AID mutant proteins comprising hyperactive deamination activity. In yet another aspect, the invention provides mutant Tet proteins capable of stalling oxidation at a 5-hydroxymethylcytosine (hmC). |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207101 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634702 | Qing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Quan Qing (Chandler, Arizona); John Albeck (Davis, California); Liang Guo (Davis, California); Min Zhao (Davis, California); Houpu Li (Tempe, Arizona) |
| ABSTRACT | A method for activating a cell-signaling pathway of interest in a cell, including applying a time-modulated localized alternating current electrical field to the cell, wherein the amplitude and frequency of the localized alternating current electrical field is selected to activate the cell signaling pathway of interest, thereby activating the cell signaling pathway. |
| FILED | Tuesday, November 05, 2019 |
| APPL NO | 16/675127 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634704 | Mallikaratchy |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York) |
| ASSIGNEE(S) | Research Foundation of the City University of New York (New York, New York) |
| INVENTOR(S) | Prabodhika Mallikaratchy (New York, New York) |
| ABSTRACT | A Ligand-guided-Selection (LIGS) method for identifying highly specific aptamers against a predetermined antigen of a target is provided. LIGS uses a stronger and highly specific bivalent binder (e.g. an antibody) interacting with its cognate antigen to displace specific aptamers from an enriched SELEX pool. Elution of the displaced aptamers provides aptamers that are specific to the predetermined antigen. |
| FILED | Friday, February 22, 2019 |
| APPL NO | 16/283156 |
| ART UNIT | 1675 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1048 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) G01N 2500/04 (20130101) G01N 2500/10 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634706 | Hamadani |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | The Trustees of the California State University (Long Beach, California) |
| INVENTOR(S) | Kambiz Hamadani (San Marcos, California) |
| ABSTRACT | Aspects of the present disclosure include methods of producing modified polypeptides and modified polypeptide-ribosome or polypeptide-mRNA complexes, and methods of screening polynucleotide and polypeptide libraries. The present disclosure also provides polypeptide libraries useful in screening for single molecule phenotypes. Also provided are kits useful for producing polypeptides capable of being modified using methods disclosed herein. |
| FILED | Tuesday, September 15, 2015 |
| APPL NO | 15/512091 |
| ART UNIT | 1675 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 1/13 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) C12N 15/1062 (20130101) Original (OR) Class C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/08 (20130101) C40B 40/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634709 | Chee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Encodia, Inc. (San Diego, California) |
| ASSIGNEE(S) | Encodia, Inc. (San Diego, California) |
| INVENTOR(S) | Mark S. Chee (San Diego, California); Kevin L. Gunderson (San Diego, California); Norihito Muranaka (San Diego, California); Brian Tate Weinert (San Diego, California) |
| ABSTRACT | Provided herein are methods for preparing and treating an analyte (e.g., a macromolecule or a plurality of macromolecules, peptides, polypeptides, and proteins) for analysis. In some embodiments, the analyte is prepared and treated in a method that includes the use of bait and capture nucleic acids, solid supports, and reaction mixtures including the bait and capture nucleic acids. In some embodiments, the analyte is coupled to a solid support. Also provided are kits containing components for performing the provided methods for preparing the analytes. In some embodiments, the methods are for preparing an analyte for sequencing. Provided herein are methods for preparing and treating an analyte (e.g., a macromolecule or a plurality of macromolecules, peptides, polypeptides, and proteins) for analysis. In some embodiments, the analyte is prepared and treated in a method that includes the use of bait and capture nucleic acids, solid supports, and reaction mixtures including the bait and capture nucleic acids. In some embodiments, the analyte is coupled to a solid support. Also provided are kits containing components for performing the provided methods for preparing the analytes. In some embodiments, the methods are for preparing an analyte for sequencing. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/458199 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634731 | Joung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Jeffry D. Sander (Ankeny, Iowa); Morgan Maeder (Brookline, Massachusetts); Yanfang Fu (Malden, Massachusetts) |
| ABSTRACT | Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs). |
| FILED | Monday, September 16, 2019 |
| APPL NO | 16/572248 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/22 (20130101) C12N 9/0071 (20130101) C12N 9/96 (20130101) C12N 9/1007 (20130101) C12N 15/01 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/1031 (20130101) C12N 2310/20 (20170501) C12N 2710/00033 (20130101) C12N 2770/00033 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 114/11 (20130101) C12Y 201/01 (20130101) C12Y 301/00 (20130101) C12Y 301/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634732 | Dever et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Daniel P. Dever (Stanford, California); Rasmus O. Bak (Stanford, California); Ayal Hendel (Stanford, California); Waracharee Srifa (Stanford, California); Matthew H. Porteus (Stanford, California) |
| ABSTRACT | In certain aspects, the present invention provides methods for inducing a stable gene modification of a target nucleic acid via homologous recombination in a primary cell, such as a primary blood cell and/or a primary mesenchymal cell. In certain other aspects, the present invention provides methods for enriching a population of genetically modified primary cells having targeted integration at a target nucleic acid. The methods of the present invention rely on the introduction of a DNA nuclease such as a Cas polypeptide and a homologous donor adeno-associated viral (AAV) vector into the primary cell to mediate targeted integration of the target nucleic acid. Also provided herein are methods for preventing or treating a disease in a subject in need thereof by administering to the subject any of the genetically modified primary cells or pharmaceutical compositions described herein to prevent the disease or ameliorate one or more symptoms of the disease. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502479 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7115 (20130101) A61K 35/28 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) Peptides C07K 14/805 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) C12N 5/0636 (20130101) C12N 5/0647 (20130101) C12N 5/0665 (20130101) C12N 9/22 (20130101) C12N 15/85 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/8645 (20130101) C12N 2310/20 (20170501) C12N 2310/311 (20130101) C12N 2310/313 (20130101) C12N 2310/3125 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634751 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 17/122321 |
| ART UNIT | 1675 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) C12Q 1/6855 (20130101) C12Q 2563/179 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634753 | Samusik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Nikolay Samusik (Mountain View, California); Garry P. Nolan (Redwood City, California); Yury Goltsev (Stanford, California); David Robert McIlwain (Palo Alto, California) |
| ABSTRACT | A method for analyzing planar sample is provided. In some cases the method comprises: (a) labelling the planar sample with a capture agent that is linked to a nucleic acid, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the nucleic acid, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185757 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6804 (20130101) C12Q 1/6804 (20130101) C12Q 1/6818 (20130101) Original (OR) Class C12Q 2565/101 (20130101) C12Q 2565/1015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634755 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TEOHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Bernd Zetsche (Cambridge, Massachusetts); Johnathan S. Gootenberg (Cambridge, Massachusetts); Omar O. Abudayyeh (Cambridge, Massachusetts); Ian Slaymaker (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554333 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6816 (20130101) C12Q 1/6832 (20130101) Original (OR) Class C12Q 2521/301 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634764 | Gundlach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington); The UAB Research Foundation (Birmingham, Alabama) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington); The UAB Research Foundation (Birmingham, Alabama) |
| INVENTOR(S) | Jens H. Gundlach (Seattle, Washington); Michael Niederweis (Homewood, Alabama); Thomas Z. Butler (Seattle, Washington); Mikhail Pavlenok (Birmingham, Alabama); Mark A. Troll (Seattle, Washington); Suja Sukumaran (Dublin, California) |
| ABSTRACT | Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/121621 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/04 (20130101) Peptides C07K 14/35 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 2523/31 (20130101) C12Q 2565/631 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/00 (20130101) G01N 27/44704 (20130101) G01N 27/44791 (20130101) G01N 33/6872 (20130101) G01N 33/48721 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634768 | Bignell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Illumina Cambridge Limited (Cambridge, United Kingdom) |
| ASSIGNEE(S) | Illumina Cambridge Limited (Cambridge, United Kingdom) |
| INVENTOR(S) | Helen Bignell (Cambridge, United Kingdom); Louise Fraser (Cambridge, United Kingdom); Niall Anthony Gormley (Cambridge, United Kingdom) |
| ABSTRACT | The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186571 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) C12Q 1/6855 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 2525/161 (20130101) C12Q 2537/143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634771 | Salk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| INVENTOR(S) | Jesse Salk (Seattle, Washington); Lawrence A. Loeb (Bellevue, Washington); Michael Schmitt (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/392175 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class C12Q 2525/179 (20130101) C12Q 2525/185 (20130101) C12Q 2525/191 (20130101) C12Q 2525/191 (20130101) C12Q 2535/119 (20130101) C12Q 2535/119 (20130101) C12Q 2535/122 (20130101) C12Q 2563/179 (20130101) C12Q 2565/514 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634772 | Sullenger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Bruce Sullenger (Durham, North Carolina); Bethany Gray (Durham, North Carolina); Michael Nichols (Durham, North Carolina) |
| ABSTRACT | Provided herein are compositions and methods for sorting and/or identifying live cells. The compositions and methods provide for staining of live cells with aptamer so particular cells can be identified within or sorted from a heterogeneous population of live cells and subsequent reversal of the staining to prepare sorted and/or identified cells in their native state. |
| FILED | Friday, March 23, 2018 |
| APPL NO | 16/496871 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 15/115 (20130101) C12N 2310/16 (20130101) C12N 2310/3517 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634779 | Kurtz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Carlos, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/661730 |
| ART UNIT | 1672 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 35/20 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635407 | Mellors et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | John Scott Mellors (Carrboro, North Carolina); Erin Anne Redman (Carrboro, North Carolina); John Michael Ramsey (Chapel Hill, North Carolina) |
| ABSTRACT | Methods, systems and devices that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer. |
| FILED | Monday, August 03, 2020 |
| APPL NO | 16/983265 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 2200/0605 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2400/049 (20130101) B01L 2400/0418 (20130101) B01L 2400/0421 (20130101) B01L 2400/0487 (20130101) B01L 2400/0622 (20130101) B01L 2400/0666 (20130101) B01L 2400/0694 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4473 (20130101) G01N 27/44743 (20130101) Original (OR) Class G01N 27/44791 (20130101) G01N 30/16 (20130101) G01N 30/7266 (20130101) G01N 2030/167 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/165 (20130101) H01J 49/167 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635415 | Cooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Zheng Ouyang (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/395909 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/91 (20130101) G01N 30/95 (20130101) Original (OR) Class G01N 33/49 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0031 (20130101) H01J 49/167 (20130101) H01J 49/168 (20130101) H01J 49/0404 (20130101) H01J 49/0409 (20130101) H01J 49/0431 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635422 | Beaumont |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jacques Beaumont (Liverpool, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacques Beaumont (Liverpool, New York) |
| ABSTRACT | A method for time constant estimation includes generating a bound for a R=1/ |
| FILED | Wednesday, January 23, 2019 |
| APPL NO | 16/255180 |
| ART UNIT | 1671 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/002 (20130101) G01N 33/48728 (20130101) Original (OR) Class Electric Digital Data Processing G06F 17/13 (20130101) Computer Systems Based on Specific Computational Models G06N 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635440 | Barthelemy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Nicolas Barthelemy (St. Louis, Missouri); Randall Bateman (St. Louis, Missouri); Eric McDade (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843470 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635480 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Yi Wang (New York, New York); Zhe Liu (New York, New York); Youngwook Kee (New York, New York); Alexey Dimov (New York, New York); Yan Wen (New York, New York); Jingwei Zhang (Woodside, New York); Pascal Spincemaille (New York, New York) |
| ABSTRACT | Exemplary quantitative susceptibility mapping methods, systems and computer-accessible medium can be provided to generate images of tissue magnetism property from complex magnetic resonance imaging data using the Bayesian inference approach, which minimizes a cost function consisting of a data fidelity term and two regularization terms. The data fidelity term is constructed directly from the complex magnetic resonance imaging data. The first prior is constructed from matching structures or information content in known morphology. The second prior is constructed from a region having an approximately homogenous and known susceptibility value and a characteristic feature on anatomic images. The quantitative susceptibility map can be determined by minimizing the cost function. Thus, according to the exemplary embodiment, system, method and computer-accessible medium can be provided for determining magnetic susceptibility information associated with at least one structure. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/142475 |
| ART UNIT | 2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0035 (20130101) A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/0263 (20130101) A61B 5/4082 (20130101) A61B 5/4088 (20130101) A61B 5/4504 (20130101) A61B 5/4872 (20130101) A61B 5/7203 (20130101) A61B 5/14542 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/24 (20130101) G01R 33/50 (20130101) G01R 33/4828 (20130101) G01R 33/5602 (20130101) G01R 33/5608 (20130101) Original (OR) Class G01R 33/56527 (20130101) G01R 33/56536 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635607 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Ki-Hee Song (Evanston, Illinois); Cheng Sun (Evanston, Illinois); Hao F. Zhang (Evanston, Illinois) |
| ABSTRACT | A method of microscopy comprises collecting an emission light; symmetrically dispersing the collected emission light into a first order (“1st”) light and a negative first order (“−1st”) light using a grating; wherein the 1st light comprises spectral information and the −1st light comprises spectral information; capturing the 1st light and the −1st light using a camera, localizing the one or more light-emitting materials using localization information determined from both the first spectral image and the second spectral image; and determining spectral information from the one or more light-emitting materials using the first spectral image and/or the second spectral image; wherein the steps of localizing and obtaining are performed simultaneously. A spectrometer for a microscope comprises a dual-wedge prism (“DWP”) for receiving and spectrally dispersing a light beam, wherein the DWP comprises a first dispersive optical device and a second dispersive optical device adhered to each other. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323302 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 2021/6417 (20130101) G01N 2201/0638 (20130101) Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 21/16 (20130101) Original (OR) Class G02B 21/36 (20130101) G02B 21/367 (20130101) G02B 27/149 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635610 | Simpson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Garth Jason Simpson (West Lafayette, Indiana); James Ulcickas (West Lafayette, Indiana); Fengyuan Deng (Watertown, Massachusetts); Changqin Ding (West Lafayette, Indiana) |
| ABSTRACT | A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/322903 |
| ART UNIT | 2424 — Cable and Television |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/26 (20130101) G02B 21/367 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 5/005 (20130101) G06T 2207/10056 (20130101) G06T 2207/20212 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636647 | Bentz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Brian Zahler Bentz (Albuquerque, New Mexico); Kevin J. Webb (West Lafayette, Indiana); Dergan Lin (West Lafayette, Indiana) |
| ABSTRACT | A method for identifying a source of florescence is disclosed which includes shining light on a subject at a first wavelength, causing emission of light at a second wavelength from the source of fluorescence, filtering out light at the first wavelength, capturing at least one 2 dimensional (2D) image of a subject having a plurality of pixels at the second wavelength, and establishing information about approximate location of a source of florescence within a tissue of the subject, selectively generating a 3D geometric model where the model is adapted to provide a model representation of the at least one 2D captured image, comparing the modeled at least one 2D captured image to the captured at least one 2D image and iteratively adjusting the model to minimize the difference, and outputting location and geometric configuration of the source of fluorescence within the tissue within the region of interest. |
| FILED | Wednesday, August 28, 2019 |
| APPL NO | 16/554188 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 15/50 (20130101) G06T 15/60 (20130101) G06T 17/00 (20130101) Original (OR) Class G06T 2207/10064 (20130101) G06T 2207/10101 (20130101) G06T 2207/30096 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636918 | Disney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Matthew D. Disney (Jupiter, Florida); Sai Velagapudi (Jupiter, Florida) |
| ABSTRACT | Methods and computer systems are described herein for identifying small molecules that bind to selected RNA structural features (e.g., to RNA secondary structures). Also described are compounds and compositions that modulate RNA function and/or activity. |
| FILED | Monday, December 10, 2018 |
| APPL NO | 16/214327 |
| ART UNIT | 1672 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Heterocyclic Compounds C07D 235/18 (20130101) C07D 235/20 (20130101) C07D 403/14 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/04 (20130101) C07H 15/234 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) G01N 2500/04 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) G16B 15/30 (20190201) Original (OR) Class G16B 30/00 (20190201) G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637355 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Xuan Zhang (St. Louis, Missouri); Lan Yang (St. Louis, Missouri); Weidong Cao (St. Louis, Missouri); Weijian Chen (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Xuan Zhang (St. Louis, Missouri); Lan Yang (St. Louis, Missouri); Weidong Cao (St. Louis, Missouri); Weijian Chen (St. Louis, Missouri) |
| ABSTRACT | An integrated circuit is disclosed. The integrated circuit includes a first resonator, a second resonator, and a coupling element. The first resonator has a first terminal and a second terminal, where the first resonator comprises a gain resistor, a gain capacitor, and a gain inductor in parallel and electrically coupling the first terminal with the second terminal. The second resonator has a third terminal and a fourth terminal, where the second resonator includes a loss resistor, a loss capacitor, and a loss inductor in parallel and electrically coupling the third terminal with the fourth terminal. The coupling element selectively couples the first terminal of the first resonator with the third terminal of the second resonator. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/446000 |
| ART UNIT | 2843 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/32 (20130101) H01P 1/36 (20130101) H01P 1/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637527 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); Board of Trustees Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts); Board of Trustees Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Xin Yu (Tübingen, Germany); Chunqi Qian (Okemos, Michigan) |
| ABSTRACT | The multi-modal imaging system, in particular for brain imaging, comprising a pump signal generator which emits at least one pump signal in the radio frequency (RF)-range with a first power P1 and a second power P2, a wireless detection unit, which comprises at least one parametric resonator circuit with multiple resonance modes, wherein the at least one parametric resonator circuit comprises at least two varactors, at least one capacitor and at least one inductance, wherein, in a first detection mode, the pump signal, having a first power P1, induces a first pump current in the at least one parametric resonator circuit, wherein the at least one parametric resonator circuit is operated below its oscillation threshold and generates a first output signal by amplifying a first input signal, which is provided due to a magnetic-resonance (MR) measurement, wherein an external receiving device receives the first output signal, wherein, in a second detection mode, the pump signal, having a second power P2, induces a second pump current in the at least one parametric resonator circuit, wherein the at least one parametric resonator circuit is operated above its oscillation threshold and generates a second output signal, wherein the second output signal is modulated with a second input signal, wherein the second input signal is provided by at least one neuronal probe device, connected to the at least one parametric resonator circuit, wherein the external receiving device receives the second output signal. |
| FILED | Wednesday, June 12, 2019 |
| APPL NO | 17/618064 |
| ART UNIT | 2849 — Electrical Circuits and Systems |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3692 (20130101) G01R 33/4806 (20130101) G01R 33/4808 (20130101) Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 5/1243 (20130101) Original (OR) Class H03B 2201/0208 (20130101) Tuning Resonant Circuits; Selecting Resonant Circuits H03J 3/185 (20130101) H03J 2200/10 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/099 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 11633146 | Leng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Ethan Yize Leng (Minneapolis, Minnesota); David Henry Porter (Plymouth, Minnesota); Gregory John Metzger (Lake Elmo, Minnesota) |
| ABSTRACT | Medical imaging analysis systems are configured to perform automatic image registration algorithms that perform three-dimensional (3D), affine, and/or intensity-based co-registration of magnetic resonance imaging (MRI) data, such as multiparametric MRI (mpMRT) data, using mutual information (MI) as a similarity metric. An apparatus comprises a computer-readable storage medium storing a plurality of imaging series of magnetic resonance imaging (MRI) data for imaged tissue of a patient; and a processor coupled to the computer-readable storage medium. The processor is configured to receive the imaging series of MRI data; identify a volume of interest (VOI) of each image of the imaging series of MRI data; compute registration parameters for the VOIs through the maximization of mutual information of the corrected VOIs; and register the VOIs using the computed registration parameters. |
| FILED | Friday, January 03, 2020 |
| APPL NO | 16/734139 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4381 (20130101) Original (OR) Class A61B 5/7275 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) G01R 33/5659 (20130101) Image Data Processing or Generation, in General G06T 3/0075 (20130101) G06T 7/0012 (20130101) G06T 7/62 (20170101) G06T 2207/10088 (20130101) G06T 2207/30081 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633192 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Certus Critical Care, Inc. (Sacramento, California); Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | CERTUS CRITICAL CARE, INC. (Salt Lake City, Utah); WAKE FOREST UNIVERSITY HEALTH SCIENCES (Winston-Salem, North Carolina) |
| INVENTOR(S) | Michael Austin Johnson (Holladay, Utah); David Poisner (Carmichael, California); Melanie Mcwade (Portland, Oregon); Timothy Williams (Winston-Salem, North Carolina); Lucas Neff (Winston-Salem, North Carolina) |
| ABSTRACT | Systems and methods for blood flow control are described herein. In some variations, a blood flow control system may comprise a blood flow control device. The blood flow control device may be placed within a body of a patient and may comprise an expandable member and a sensor. The sensor may be configured to measure at least one of a physiologic condition of the patient and a pressure associated with the expandable member. The blood flow control system may include at least one controller communicably coupled to the sensor to: receive data indicative of at least one of the physiologic condition of the patient and the pressure associated with the expandable member from the sensor, compare the received data with target data, identify at least one error based on the comparison, and in response to identifying the error, inhibit at least one function of the blood flow control system. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 17/365932 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02158 (20130101) A61B 5/4836 (20130101) A61B 17/12109 (20130101) A61B 17/12136 (20130101) Original (OR) Class A61B 34/20 (20160201) A61B 34/25 (20160201) A61B 2017/00022 (20130101) A61B 2017/00075 (20130101) A61B 2017/00119 (20130101) A61B 2017/00557 (20130101) A61B 2090/064 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633428 | O'Malley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/650640 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633429 | O'Malley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/650645 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633551 | Jensen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hansen Pharmaceutical, LLC (South Miami, Florida) |
| ASSIGNEE(S) | Hansen Pharmaceutical, LLC (South Miami, Florida) |
| INVENTOR(S) | Jeffrey L. Jensen (Phoenix, Arizona); Jason R. Hanft (Coral Gables, Florida); Steve Jensen (Boston, Massachusetts) |
| ABSTRACT | Embodiments of the present disclosure provide systems and devices for delivering gaseous Nitric Oxide (gNO) under therapeutic parameters to reduce infection in a subject. Certain embodiments include devices and systems for delivering pressurized gNO to reduce bioburden and promote healing in the wounds of subjects having various disease conditions, including skin and soft tissue infections (SSTIs) and osteomyelitis. In some embodiments, the present disclosure provides portable wound healing devices for delivering pressurized gNO to the site of a wound to treat various disease conditions in a subject. Other embodiments relate to systems and devices for delivering and for monitoring gaseous Nitric Oxide (gNO) under therapeutic parameters of use to treat a subject. In certain embodiment, the devices include a subject interface unit comprising sensors for detecting gNO pressure and/or gNO flow. |
| FILED | Monday, January 27, 2020 |
| APPL NO | 16/773676 |
| ART UNIT | 3783 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 13/00 (20130101) Original (OR) Class A61M 35/30 (20190501) A61M 2202/20 (20130101) A61M 2202/203 (20130101) A61M 2202/206 (20130101) A61M 2202/0275 (20130101) A61M 2205/3327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633931 | Steinacher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Arlington, Virginia) |
| INVENTOR(S) | Philip P. Steinacher (Carrollton, Illinois); Randall Dow Wilkerson (O'Fallon, Missouri); James Rodney Fox (University City, Missouri); Michael Palmore Matlack (St. Charles, Missouri); Ryan Joseph Merriman (Ballwin, Missouri); Donald C. Besselsen (Lake St. Louis, Missouri); David Phillip Bruk (St. Louis, Missouri) |
| ABSTRACT | A method and apparatus for a continuous compression molding machine. The continuous compression molding machine comprises a tooling die, extending through a heating zone and a cooling zone, a tooling sleeve, and a biasing system. The tooling sleeve corresponds to the tooling die and is for use in forming a thermoplastic composite part from a thermoplastic composite charge when the tooling sleeve with the thermoplastic composite charge is moved with respect to the tooling die through the heating zone and the cooling zone. The biasing system is configured to hold the thermoplastic charge at a first angle within the heating zone and hold the thermoplastic composite charge at a second angle within the cooling zone, as the tooling sleeve moves through the heating zone and the cooling zone with the thermoplastic composite charge. The first angle is different from the second angle. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 16/992775 |
| ART UNIT | 1748 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 43/28 (20130101) B29C 43/34 (20130101) B29C 43/44 (20130101) B29C 43/52 (20130101) B29C 70/50 (20130101) B29C 2043/522 (20130101) B29C 2043/527 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 99/0003 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2101/12 (20130101) B29K 2105/256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633999 | Flory et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRATT and MILLER ENGINEERING AND FABRICATION, INC. (New Hudson, Michigan) |
| ASSIGNEE(S) | PRATT and MILLER ENGINEERING AND FABRICATION, LLC (New Hudson, Michigan) |
| INVENTOR(S) | Kenneth J. Flory (West Bloomfield, Michigan); Jesper Slattengren (Ann Arbor, Michigan); Guido Francesco Ritelli (Farminton Hills, Michigan) |
| ABSTRACT | A hydraulic suspension system for a motor vehicle having at least a pair of road engaging wheels. The suspension system includes, a hydraulic cylinder coupled with the each of the pair of road engaging wheels, the hydraulic cylinder defining a cap end volume and a rod end volume separated by a piston. A hydraulic supply circuit for the hydraulic cylinder includes, a high pressure hydraulic source, a low pressure hydraulic drain, a pair of hydraulic sub circuits each coupled to one of the hydraulic cylinder cap and rod end volumes. Each hydraulic sub circuit includes, a proportional supply flow valve coupled with the high pressure hydraulic source and one of the cylinder volumes, a return flow control proportional valve coupled with the low pressure hydraulic drain and the one cylinder volume, and an accumulator coupled to the associated hydraulic cylinder volume through an accumulator fill control proportional valve. |
| FILED | Friday, April 19, 2019 |
| APPL NO | 17/048874 |
| ART UNIT | 3616 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Vehicle Suspension Arrangements B60G 11/265 (20130101) Original (OR) Class B60G 17/056 (20130101) B60G 2202/154 (20130101) B60G 2202/413 (20130101) B60G 2202/414 (20130101) B60G 2202/416 (20130101) B60G 2300/07 (20130101) B60G 2500/114 (20130101) B60G 2600/182 (20130101) B60G 2800/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634228 | Van Keuren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sikorsky Aircraft Corporation (Stratford, Connecticut) |
| ASSIGNEE(S) | SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut) |
| INVENTOR(S) | Kevin S. Van Keuren (Oxford, Connecticut); Donald W. Lamb, Jr. (North Haven, Connecticut); Jose A. Dasilva (Cheshire, Connecticut); Malick Daniel Kelly (Milford, Connecticut) |
| ABSTRACT | A flow management system for delivering air to a heat load of an aircraft includes a cover having an opening for receiving and directing an airflow, and a duct defining a non-linear fluid flow path. The fluid flow path operably couples the opening and the heat load. A configuration of the fluid flow path reduces a velocity of the airflow therein while minimizing a pressure drop of the airflow. |
| FILED | Wednesday, November 01, 2017 |
| APPL NO | 15/801057 |
| ART UNIT | 3762 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Aeroplanes; Helicopters B64C 7/00 (20130101) B64C 27/04 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 13/00 (20130101) B64D 13/06 (20130101) Original (OR) Class B64D 2013/0614 (20130101) B64D 2013/0618 (20130101) B64D 2013/0651 (20130101) B64D 2013/0662 (20130101) B64D 2033/0246 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634229 | Lyons et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Karen Swider Lyons (Alexandria, Virginia); Richard J Foch (Upper Marlboro, Maryland); Gregory Page (Arnold, Maryland); Michael Schuette (Vienna, Virginia); Aaron D. Kahn (Alexandria, Virginia); Richard Stroman (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Karen Swider Lyons (Alexandria, Virginia); Richard J Foch (Upper Marlboro, Maryland); Gregory Page (Arnold, Maryland); Michael Schuette (Vienna, Virginia); Aaron D. Kahn (Alexandria, Virginia); Richard Stroman (Washington, District of Columbia) |
| ABSTRACT | Disclosed herein is a system comprising: a hydrogen fuel cell; a fuel storage tank; a regulator coupled to the storage tank and the fuel cell; an electronic auto pilot; a rechargeable battery; a power electronics module for delivering power from the fuel cell to the autopilot and the battery; and a heat exchanger coupled to the fuel cell. The fuel cell is characterized by: a minimum continuous power output of no more than 25 W; a maximum continuous power output of no less than 5000 W; a specific power of at least 200 W/kg based on the mass of the fuel cell and any control electronics, cooling components, air delivery components, and water management components; an ability to operate at least 2 psig of hydrogen at an inlet; and an ability to operate at temperatures up to 90° C. |
| FILED | Tuesday, April 05, 2011 |
| APPL NO | 12/803051 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeroplanes; Helicopters B64C 2201/04 (20130101) B64C 2201/06 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/02 (20130101) Original (OR) Class B64D 2041/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634257 | Weimer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Terumo BCT Biotechnologies, LLC (Lakewood, Colorado) |
| ASSIGNEE(S) | Terumo BCT Biotechnologies, LLC (Lakewood, Colorado) |
| INVENTOR(S) | Kirk L. Weimer (Green Valley, Arizona); Nate T. Johnson (Highlands Ranch, Colorado); Dennis J. Hlavinka (Arvada, Colorado); Kestas P. Parakininkas (Englewood, Colorado) |
| ABSTRACT | Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas. The method includes creating a temporary seal between the non-breathable section of the container and the breathable section, inputting a liquid into the non-breathable section, freezing the liquid, removing the temporary seal to allow vapor transport between the non-breathable section and the breathable section, and adding heat energy the frozen liquid under vacuum. |
| FILED | Wednesday, September 02, 2020 |
| APPL NO | 17/010083 |
| ART UNIT | 3753 — Fluid Handling and Dispensing |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0263 (20130101) A01N 1/0284 (20130101) A01N 1/0289 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/10 (20130101) A61J 1/1468 (20150501) A61J 1/2093 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 51/241 (20130101) Original (OR) Class Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 5/06 (20130101) F26B 25/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634429 | Elder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Delwin Elder (Seattle, Washington); Lewis Johnson (Seattle, Washington); Bruce Robinson (Seattle, Washington); Huajun Xu (Seattle, Washington) |
| ABSTRACT | Chromophores with large hyperpolarizabilities, films with electro-optic activity comprising the chromophores, and electro-optic devices comprising the chromophores are disclosed. |
| FILED | Monday, April 04, 2022 |
| APPL NO | 17/713055 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 307/28 (20130101) C07D 495/04 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0812 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3613 (20130101) G02F 1/3614 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0061 (20130101) H01L 51/0068 (20130101) H01L 51/0074 (20130101) H01L 51/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634446 | Mirica et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Katherine A. Mirica (Hanover, New Hampshire); Zheng Meng (West Lebanon, New Hampshire); Robert M. Stolz (Lyme, New Hampshire) |
| ABSTRACT | In an embodiment, the present disclosure pertains to a method of sensing an analyte in a sample by: (1) exposing the sample to an electrode that includes a covalent-organic framework with a plurality of metal-coordinated aromatic units that are linked to one another by aromatic linkers; (2) detecting a change in a property of the electrode; and (3) correlating the change in the property to the presence or absence of the analyte. In an additional embodiment, the present disclosure pertains to said covalent-organic frameworks. Additional embodiments of the present disclosure pertain to methods of making the covalent-organic frameworks. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 16/855819 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/045 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/126 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634534 | Iezzi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Erick B. Iezzi (Mars, Pennsylvania); Eugene Camerino (Dumfries, Virginia); Grant Daniels (Lorton, Virginia); James H. Wynne (Alexandria, Virginia) |
| ABSTRACT | A process of: providing a polyfunctional compound selected from polyisocyanate, polyacrylate, and polyepoxy; and reacting the polyfunctional compound with a hydroxyl- or amine-terminated silyl-containing compound. The polyfunctional compound and the silyl-containing compound are at least difunctional. A thermoset made by this process. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/917179 |
| ART UNIT | 1765 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/72 (20130101) C08G 18/82 (20130101) Original (OR) Class C08G 18/3897 (20130101) C08G 59/14 (20130101) C08G 77/00 (20130101) C08G 77/60 (20130101) C08G 77/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634702 | Qing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Quan Qing (Chandler, Arizona); John Albeck (Davis, California); Liang Guo (Davis, California); Min Zhao (Davis, California); Houpu Li (Tempe, Arizona) |
| ABSTRACT | A method for activating a cell-signaling pathway of interest in a cell, including applying a time-modulated localized alternating current electrical field to the cell, wherein the amplitude and frequency of the localized alternating current electrical field is selected to activate the cell signaling pathway of interest, thereby activating the cell signaling pathway. |
| FILED | Tuesday, November 05, 2019 |
| APPL NO | 16/675127 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634753 | Samusik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Nikolay Samusik (Mountain View, California); Garry P. Nolan (Redwood City, California); Yury Goltsev (Stanford, California); David Robert McIlwain (Palo Alto, California) |
| ABSTRACT | A method for analyzing planar sample is provided. In some cases the method comprises: (a) labelling the planar sample with a capture agent that is linked to a nucleic acid, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the nucleic acid, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185757 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6804 (20130101) C12Q 1/6804 (20130101) C12Q 1/6818 (20130101) Original (OR) Class C12Q 2565/101 (20130101) C12Q 2565/1015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634797 | Schuh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Christopher A. Schuh (Wayland, Massachusetts); Mansoo Park (Seoul, South Korea) |
| ABSTRACT | Provided in one embodiment is a method, comprising: sintering a plurality of nanocrystalline particulates to form a nanocrystalline alloy, wherein at least some of the nanocrystalline particulates may include a non-equilibrium phase comprising a first metal material and a second metal material, and the first metal material may be soluble in the second metal material. The sintered nanocrystalline alloy may comprise a bulk nanocrystalline alloy. |
| FILED | Monday, August 12, 2019 |
| APPL NO | 16/537996 |
| ART UNIT | 1738 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/07 (20220101) B22F 1/07 (20220101) B22F 3/10 (20130101) B22F 3/10 (20130101) B22F 3/1035 (20130101) B22F 2998/10 (20130101) B22F 2998/10 (20130101) Alloys C22C 1/045 (20130101) C22C 27/04 (20130101) Original (OR) Class C22C 27/06 (20130101) C22C 2200/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634806 | Holder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Arlington, Virginia) |
| INVENTOR(S) | Scott M. Holder (Cherry Hill, New Jersey); Dale J. Weires (Hockessin, Delaware) |
| ABSTRACT | Methods of hardening a case-nitrided metal article, methods of producing a hardened case-nitrided metal article, and hardened case-nitrided metal articles. The methods of hardening a case-nitrided metal article include heating the case-nitrided metal article to an aging temperature, maintaining the case-nitrided metal article at the aging temperature for an aging time, and cooling the case-nitrided metal article from the aging temperature. The methods of producing a hardened case-nitrided metal article include case-nitriding a metal article to produce a case-nitrided metal article and subsequently hardening the case-nitrided metal article. The hardened case-nitrided metal article comprises a body formed of a metal or a metal alloy, a surface surrounding the body, and a nitrided case layer formed in the body and extending inwardly from the surface of the body toward the core that includes a hardness that is greater than that of an otherwise equivalent case-nitrided metal article. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528996 |
| ART UNIT | 1759 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/183 (20130101) Original (OR) Class Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 8/24 (20130101) C23C 8/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634834 | Hobart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Karl D. Hobart (Alexandria, Virginia); Tatyana I. Feygelson (Springfield, Virginia); Marko J. Tadjer (Vienna, Virginia); Travis J. Anderson (Alexandria, Virginia); Andrew D. Koehler (Alexandria, Virginia); Samuel Graham, Jr. (Lithonia, Georgia); Mark Goorsky (Valencia, California); Zhe Cheng (Atlanta, Georgia); Luke Yates (Atlanta, Georgia); Tingyu Bai (Los Angeles, California); Yekan Wang (Los Angeles, California) |
| ABSTRACT | A method for growing polycrystalline diamond films having engineered grain growth and microstructure. Grain growth of a polycrystalline diamond film on a substrate is manipulated by growing the diamond on a nanopatterned substrate having features on the order of the initial grain size of the diamond film. By growing the diamond on such nanopatterned substrates, the crystal texture of a polycrystalline diamond film can be engineered to favor the preferred <110> orientation texture, which in turn enhances the thermal conductivity of the diamond film. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/409916 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/18 (20130101) C30B 29/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635045 | Parker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aerojet Rocketdyne, Inc. (Sacramento, California) |
| ASSIGNEE(S) | AEROJET ROCKETDYNE, INC (Canoga Park, California) |
| INVENTOR(S) | Douglas S. Parker (Sacramento, California); Daniel P. Cap (Sacramento, California); Frederick E. Dodd (Sacramento, California) |
| ABSTRACT | An injector element for a liquid propellant rocket engine includes an oxidizer conduit, a central cavity that is fluidly coupled with the oxidizer conduit downstream of the oxidizer conduit, a first annulus that at least partially surrounds the oxidizer conduit and is fluidly coupled with an ignition fluid supply downstream of the ignition fluid supply, and a second annulus that at least partially surrounds the oxidizer conduit and is fluidly coupled with a fuel supply downstream of the fuel supply. The second annulus is fluidly coupled between the first annulus and the central cavity. |
| FILED | Thursday, June 29, 2017 |
| APPL NO | 16/316685 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Jet-propulsion Plants F02K 9/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635064 | Kartalov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California); The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Emil P. Kartalov (Pacific Grove, California); Axel Scherer (Barnard, Vermont) |
| ABSTRACT | Artificial muscles comprising a body of dielectric elastomer, wherein the body contains a pair of microfluidic networks are presented. Each microfluidic network includes a plurality of channels fluidically coupled via a manifold. The channels of the microfluidic networks are interdigitated and filled with conductive fluid such that each set of adjacent channels functions as the electrodes of an electroactive polymer (EAP) actuator. By using the manifolds as compliant wiring to energize the electrodes, artificial muscles in accordance with the present disclosure mitigate some or all of the reliability problems associated with prior-art artificial muscles. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/338393 |
| ART UNIT | 2837 — Electrical Circuits and Systems |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/08 (20130101) A61F 2/70 (20130101) A61F 2/482 (20210801) A61F 2002/0894 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/02 (20130101) A61H 3/00 (20130101) A61H 2201/1207 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/10 (20130101) B25J 9/1075 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) Original (OR) Class Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 13/044 (20130101) F15B 15/103 (20130101) F15B 21/065 (20130101) F15B 2215/305 (20130101) Electric Machines Not Otherwise Provided for H02N 1/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635094 | Keplinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado (Denver, Colorado) |
| INVENTOR(S) | Christoph Matthias Keplinger (Gerlinger, Germany); Xingrui Wang (Stuttgart, Germany); Shane Karl Mitchell (Denver, Colorado) |
| ABSTRACT | High strain hydraulically amplified self-healing electrostatic transducers having increased maximum theoretical and practical strains are disclosed. In particular, the actuators include electrode configurations having a zipping front created by the attraction of the electrodes that is configured orthogonally to a strain axis along which the actuators. This configuration produces increased strains. In turn, various form factors for the actuator configuration are presented including an artificial circular muscle and a strain amplifying pulley system. Other actuator configurations are contemplated that include independent and opposed electrode pairs to create cyclic activation, hybrid electrode configurations, and use of strain limiting layers for controlled deflection of the actuator. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/117418 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1075 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 5/006 (20130101) Original (OR) Class F15B 15/103 (20130101) F15B 21/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635312 | Fox et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Richard B. Fox (San Tan Valley, Arizona); John Rogers (Weymouth, United Kingdom); Ian Kerr (Broadway, United Kingdom); Daniel Pearce (Chard, United Kingdom) |
| ABSTRACT | This disclosure is directed to methods, computer program products, and systems for calibrating one or more remote sensing devices in an environment. The disclosed technology relates to a calibration device configured to determine measurement data within an environment. The calibration device may transmit the measurement values, or other calibration data items, to a remote sensing device via a wireless link while the remote sensing device stays with a structure in which the remote sensing device is commissioned to operate. In response to receiving the calibration data items, the remote sensing device may adjust one or more settings of the remote sensing device in order to satisfy a calibration threshold. |
| FILED | Monday, July 06, 2020 |
| APPL NO | 16/921401 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 3/022 (20130101) G01D 3/028 (20130101) G01D 18/004 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635315 | Williams et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Jeremiah C Williams (Dayton, Ohio); Hengky Chandrahalim (Beavercreek, Ohio) |
| ABSTRACT | A passive microscopic flow sensor includes a three-dimensional microscopic optical structure formed on a cleaved tip of an optical fiber. The three-dimensional microscopic optical structure includes a post attached off-center to and extending longitudinally from the cleaved tip of the optical fiber. A rotor of the three-dimensional microscopic optical structure is received for rotation on the post. The rotor has more than one blade. Each blade has a reflective undersurface that reflects a light signal back through the optical fiber when center aligned with the optical fiber, the blades of the rotor shaped to rotate at a rate related to a flow rate. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245645 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/103 (20130101) Original (OR) Class G01F 1/115 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 11/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635330 | Goldstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jordan Goldstein (Cambridge, Massachusetts); Christopher Louis Panuski (Somerville, Massachusetts); Dirk Robert Englund (Brookline, Massachusetts) |
| ABSTRACT | Optical microcavity resonance measurements can have readout noise matching the fundamental limit set by thermal fluctuations in the cavity. Small-heat-capacity, wavelength-scale microcavities can be used as bolometers that bypass the limitations of other bolometer technologies. The microcavities can be implemented as photonic crystal cavities or micro-disks that are thermally coupled to strong mid-IR or LWIR absorbers, such as pyrolytic carbon columns. Each microcavity and the associated absorber(s) rest on hollow pillars that extend from a substrate and thermally isolate the cavity and the absorber(s) from the rest of the bolometer. This ensures that thermal transfer to the absorbers is predominantly from radiation as opposed to from conduction. As the absorbers absorb thermal radiation, they shift the resonance wavelength of the cavity. The cavity transduces this thermal change into an optical signal by reflecting or scattering more (or less) near-infrared (NIR) probe light as a function of the resonance wavelength shift. |
| FILED | Monday, May 31, 2021 |
| APPL NO | 17/335017 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/34 (20130101) G01J 5/0818 (20130101) G01J 5/0853 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635343 | Sarlashkar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sikorsky Aircraft Corporation (Stratford, Connecticut) |
| ASSIGNEE(S) | Sikorsky Aircraft Corporation (Stratford, Connecticut) |
| INVENTOR(S) | Avinash V. Sarlashkar (Pittsford, New York); Theodore S. Meyer (Pavilion, New York); Matthew P. Harrigan (Horseheads, New York) |
| ABSTRACT | A fastener health monitoring system includes a structure including a first component and a second component, one or more fasteners securing the first component to the second component, and an optical fiber arranged adjacent to the one or more fasteners. The fiber is configured to detect strain on the structure from the one or more fasteners. Strain patterns are derivable from sensed data from the optical fiber, and any deviation in strain value greater than a threshold value at a particular fiber position along the optical fiber is indicative of a missing, damaged, or loosened fastener amongst the one or more of fasteners corresponding to that particular fiber position. |
| FILED | Wednesday, September 27, 2017 |
| APPL NO | 16/647061 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/242 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 5/0041 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635353 | Fedick |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Patrick W. Fedick (Ridgecrest, California) |
| ABSTRACT | A sample collection device is composed of a conductive polymer. The conductive polymer includes a mixture of carbon nanotubes and a polymer. The sample collection device has a hole at a tip of the sample collection device with the hole having a size ranging from about 0.15 mm to about 0.25 mm. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 16/903647 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/08 (20130101) Original (OR) Class G01N 33/24 (20130101) G01N 2223/616 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635407 | Mellors et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | John Scott Mellors (Carrboro, North Carolina); Erin Anne Redman (Carrboro, North Carolina); John Michael Ramsey (Chapel Hill, North Carolina) |
| ABSTRACT | Methods, systems and devices that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer. |
| FILED | Monday, August 03, 2020 |
| APPL NO | 16/983265 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 2200/0605 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2400/049 (20130101) B01L 2400/0418 (20130101) B01L 2400/0421 (20130101) B01L 2400/0487 (20130101) B01L 2400/0622 (20130101) B01L 2400/0666 (20130101) B01L 2400/0694 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4473 (20130101) G01N 27/44743 (20130101) Original (OR) Class G01N 27/44791 (20130101) G01N 30/16 (20130101) G01N 30/7266 (20130101) G01N 2030/167 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/165 (20130101) H01J 49/167 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635456 | Ofek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Nissim Ofek (New Haven, Connecticut); Luigi Frunzio (North Haven, Connecticut); Michel Devoret (New Haven, Connecticut); Robert J. Schoelkopf, III (Madison, Connecticut) |
| ABSTRACT | The present application describes a waveform processor for control of quantum mechanical systems. The waveform processor may be used to control quantum systems used in quantum computation, such as qubits. According to some embodiments, a waveform processor includes a first sequencer configured to sequentially execute master instructions according to a defined order and output digital values in response to the executed master instructions, and a second sequencer coupled to the first sequencer and configured to generate analog waveforms at least in part by transforming digital waveforms according to digital values received from the first sequencer. The analog waveforms are applied to a quantum system. In some embodiments, the waveform processor further includes a waveform analyzer configured to integrate analog waveforms received from a quantum system and output results of said integration to the first sequencer. |
| FILED | Friday, February 10, 2017 |
| APPL NO | 16/076411 |
| ART UNIT | 2863 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 23/16 (20130101) Original (OR) Class G01R 33/20 (20130101) G01R 33/032 (20130101) G01R 33/038 (20130101) G01R 33/1284 (20130101) Electric Digital Data Processing G06F 9/3877 (20130101) G06F 9/5027 (20130101) G06F 15/16 (20130101) G06F 17/14 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635528 | Weighton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| ASSIGNEE(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| INVENTOR(S) | James K. Weighton (Central City, Iowa); Kenneth Cogan (Cedar Rapids, Iowa); Benjamin Graubard (Alburnett, Iowa); Troy V. Mundt (North Liberty, Iowa); Jimmey Stultz (Cedar Rapids, Iowa); Meraj Choudhury (Cedar Rapids, Iowa) |
| ABSTRACT | A navigation satellite receiver system is disclosed. The system includes a host receiver. The host receiver includes a user interface, a module connector, and a controller coupled to the user interface and the module connector. The system further includes a receiver module operably coupled to the receiver module. The receiver module includes an antenna configured to receive one or more satellite navigation signal. The receiver module further includes an interface receiver card operably coupled to the module antenna. The interface receiver card is configured to process the one or more navigation signals. The receiver module further includes a host connector communicatively coupled to the interface receiver card and is configured to couple to the module connector. The module includes a housing configured to receive and protect the interface receiver card, the antenna, and the host connector. |
| FILED | Wednesday, August 12, 2020 |
| APPL NO | 16/991898 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/10 (20130101) G01S 19/13 (20130101) G01S 19/36 (20130101) G01S 19/37 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 1/241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635546 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts); Massachusetts Institute of Technoloqy (Cambridge, Massachusetts) |
| INVENTOR(S) | Hualiang Zhang (Arlington, Massachusetts); Jun Ding (Lowell, Massachusetts); Juejun Hu (Newton, Massachusetts); Tian Gu (Fairfax, Virginia); Hanyu Zheng (Cambridge, Massachusetts) |
| ABSTRACT | An optical device as described herein includes a host substrate fabricated from a dielectric material transparent in the Infrared range. Additionally, the optical device as discussed herein includes multiple elements disposed on the host substrate. The multiple elements are spaced apart from each other on the host substrate in accordance with a desired pattern. Each of the multiple elements disposed in the host substrate is fabricated from a second material having a refractive index of greater than 4.5. Such an optical device provides an improvement over conventional optical devices that operate in the Infrared range. |
| FILED | Thursday, June 28, 2018 |
| APPL NO | 16/624054 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/042 (20130101) C23C 14/048 (20130101) C23C 14/0623 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class G02B 5/204 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/3178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635568 | Coolbaugh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| INVENTOR(S) | Douglas Coolbaugh (Albany, New York); Gerald L. Leake, Jr. (Albany, New York) |
| ABSTRACT | There is set forth herein a photonics device. The photonics device can comprise a substrate, a conductive material formation, a dielectric stack, and a barrier layer. The photonics device can transmit a light signal. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/809580 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/122 (20130101) Original (OR) Class G02B 6/136 (20130101) G02B 2006/12061 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/486 (20130101) H01L 21/4857 (20130101) H01L 21/76202 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636046 | Tran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Nhut Tran (Natick, Massachusetts); J. Ryan Prince (Stow, Massachusetts); Martin Klingensmith (Arlington, Massachusetts) |
| ABSTRACT | An embodiment is directed to a hardware circuit for encrypting and/or decrypting data transmitted between a processor and a memory. The circuit is situated between the processor and memory. The circuit includes a first interface communicatively coupled to the processor via a set of buses. The circuit also includes a second interface communicatively coupled to the memory. The circuit further includes hardware logic capable of executing an encryption operation on data transmitted between the processor and memory, without adding latency to data transmission speed between the processor and the memory. The hardware logic is configured to encrypt data received at the first interface from the processor, and transmit the encrypted data to the memory via the second interface. The hardware logic is also configured to decrypt data received at the second interface from the memory, and transmit the decrypted data to the processor via the first interface. |
| FILED | Friday, November 15, 2019 |
| APPL NO | 16/685600 |
| ART UNIT | 2494 — Cryptography and Security |
| CURRENT CPC | Electric Digital Data Processing G06F 12/1408 (20130101) Original (OR) Class G06F 21/78 (20130101) G06F 21/602 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0894 (20130101) H04L 2209/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636299 | Fink et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Functional Fabrics of America (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Advanced Functional Fabrics of America, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Yoel Fink (Brookline, Massachusetts); Nicholas Dimitruk (Belmont, Massachusetts); Federico Bescotti (Boston, Massachusetts); Catherine Chapman (Spartanburg, South Carolina) |
| ABSTRACT | Exemplary embodiments use a single, physical embodiment that compiles independent machine-readable codes together with little to no space in between codes. This physical embodiment is in two primary forms—adhesive tape or fabric strips with hook and loop backing. A code reader device, with software compatible with the machine-readable codes, can rapidly or simultaneously aggregate independent codes together on the physical embodiment in order to assign them to one or more digital addresses. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401939 |
| ART UNIT | 2876 — Optics |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/06037 (20130101) G06K 19/06093 (20130101) Original (OR) Class Displaying; Advertising; Signs; Labels or Name-plates; Seals G09F 3/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636329 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida) |
| INVENTOR(S) | Kan Li (Gainesville, Florida); Jose C. Principe (Gainesville, Florida) |
| ABSTRACT | Various examples related to real time detection with recurrent networks are presented. These can be utilized in automatic insect recognition to provide accurate and rapid in situ identification. In one example, among others, a method includes training parameters of a kernel adaptive autoregressive-moving average (KAARMA) using a signal of an input space. The signal can include source information in its time varying structure. A surrogate embodiment of the trained KAARMA can be determined based upon clustering or digitizing of the input space, binarization of the trained KAARMA state and a transition table using the outputs of the trained KAARMA for each input in the training set. A recurrent network detector can then be implemented in processing circuitry (e.g., flip-flops, FPGA, ASIC, or dedicated VLSI) based upon the surrogate embodiment of the KAARMA The recurrent network detector can be configured to identify a signal class. |
| FILED | Tuesday, August 28, 2018 |
| APPL NO | 16/114352 |
| ART UNIT | 2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00503 (20130101) G06K 9/00536 (20130101) G06K 9/622 (20130101) G06K 9/6273 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/063 (20130101) G06N 3/084 (20130101) G06N 3/088 (20130101) G06N 3/0445 (20130101) G06N 3/0454 (20130101) G06N 3/0481 (20130101) Image or Video Recognition or Understanding G06V 10/955 (20220101) G06V 20/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636344 | Savvides et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Marios Savvides (Pittsburgh, Pennsylvania); Dipan Kumar Pal (Pittsburgh, Pennsylvania) |
| ABSTRACT | During training of deep neural networks, a Copernican loss (LC) is designed to augment the standard Softmax loss to explicitly minimize intra-class variation and simultaneously maximize inter-class variation. Copernican loss operates using the cosine distance and thereby affects angles leading to a cosine embedding, which removes the disconnect between training and testing. |
| FILED | Tuesday, March 12, 2019 |
| APPL NO | 16/299498 |
| ART UNIT | 2122 — AI & Simulation/Modeling |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636346 | Linsley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | Brown University (Providence, Rhode Island) |
| INVENTOR(S) | Drew Linsley (Providence, Rhode Island); Junkyung Kim (London, United Kingdom); Thomas Serre (East Greenwich, Rhode Island); Alekh Karkada Ashok (Karnataka, India); Lakshmi Narasimhan Govindarajan (Providence, Rhode Island); Rex Gerry Liu (Providence, Rhode Island) |
| ABSTRACT | A method includes providing a computer system, the computer system including at least a processor and a memory, the memory including at least an operating system, executing a process in the memory, the process including providing a recurrent circuit model, and converting the recurrent circuit model into a recurrent neural network that can be fit with gradient descent. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 16/868392 |
| ART UNIT | 2631 — Digital Communications |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) G06N 3/084 (20130101) Original (OR) Class G06N 3/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636372 | Inoue et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Ken Inoue (Elmsford, New York); Maika Takita (Croton-on-Hudson, New York); Antonio Corcoles-Gonzalez (Mount Kisco, New York); Scott Douglas Lekuch (New York, New York) |
| ABSTRACT | Systems, computer-implemented methods, and computer program products that can facilitate determining a state of a qubit are described. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise an output receiving component that can receive, in response to a request, output representative of a quantum state of a qubit of a quantum computing device, and a classifying component that classifies the quantum state of the qubit of the quantum computing device based on the output representative of the quantum state of the qubit. The system can further include a configuring component that can configure the classifying component based on a characteristic of the request. |
| FILED | Thursday, November 07, 2019 |
| APPL NO | 16/677178 |
| ART UNIT | 2851 — Printing/Measuring and Testing |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6269 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class G06N 10/20 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637355 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Xuan Zhang (St. Louis, Missouri); Lan Yang (St. Louis, Missouri); Weidong Cao (St. Louis, Missouri); Weijian Chen (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Xuan Zhang (St. Louis, Missouri); Lan Yang (St. Louis, Missouri); Weidong Cao (St. Louis, Missouri); Weijian Chen (St. Louis, Missouri) |
| ABSTRACT | An integrated circuit is disclosed. The integrated circuit includes a first resonator, a second resonator, and a coupling element. The first resonator has a first terminal and a second terminal, where the first resonator comprises a gain resistor, a gain capacitor, and a gain inductor in parallel and electrically coupling the first terminal with the second terminal. The second resonator has a third terminal and a fourth terminal, where the second resonator includes a loss resistor, a loss capacitor, and a loss inductor in parallel and electrically coupling the third terminal with the fourth terminal. The coupling element selectively couples the first terminal of the first resonator with the third terminal of the second resonator. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/446000 |
| ART UNIT | 2843 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/32 (20130101) H01P 1/36 (20130101) H01P 1/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637359 | Rao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | THE AEROSPACE CORPORATION (El Segundo, California) |
| INVENTOR(S) | Vikram M. Rao (Torrance, California); Vahagn Petrosyan (Northridge, California) |
| ABSTRACT | Embedded antennas in integrated circuits, and methods of making and using the same, are provided herein. An integrated circuit within a semiconductor die may include a control circuit; an antenna configured to wirelessly receive a control signal at a predefined frequency; and an interconnect configured to provide the received control signal from the antenna to the control circuit. The control circuit may be configured to control a function of the integrated circuit responsive to the received control signal. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/366657 |
| ART UNIT | 2844 — Electrical Circuits and Systems |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/66 (20130101) H01L 2223/6677 (20130101) Antennas, i.e Radio Aerials H01Q 1/2283 (20130101) Original (OR) Class Pulse Technique H03K 19/17744 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637516 | Walecka et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Andrew C. Walecka (Tucson, Arizona); Andrew Thompson (Vail, Arizona) |
| ABSTRACT | A system and method uses field-oriented control (FOC) of a multi-phase motor to prevent thermal runaway of the thermal battery that powers the motor. An offset is applied to the flux command signal to ensure that the power level drawn from the thermal battery exceeds a minimum power level to avoid thermal runaway. This is done without any additional hardware, hence the reduced cost, inefficiencies and packaging volume of such hardware. In different modes, the offset is applied to prevent thermal runaway regardless of torque production, when the system is in failure and torque production is zero, for variable and intermittent periods when torque production is zero, and during normal operation to augment power drawn to produce torque. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 17/379450 |
| ART UNIT | 2846 — Electrical Circuits and Systems |
| CURRENT CPC | Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 21/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637613 | Learned |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Rachel E. Learned (Waltham, Massachusetts) |
| ABSTRACT | In some embodiments, a method for mitigating interference in a channel having multiple users can include: determining a starting angle based on a direction of a signal of interest (SOI); iteratively steering a beam away from the starting angle in opposite directions and calculating a grade of the beam; choosing the beam at a current angle as a receive beam based on the beam grade; receiving a signal using the receive beam; and decoding the SOI from one or more interfering signals using successive interference cancellation multi-user detection (SIC MUD) on the received signal. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 16/880370 |
| ART UNIT | 2631 — Digital Communications |
| CURRENT CPC | Transmission H04B 1/7103 (20130101) H04B 7/086 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0048 (20130101) H04L 25/0204 (20130101) Wireless Communication Networks H04W 72/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637702 | Khoury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| INVENTOR(S) | Joud Khoury (Boston, Massachusetts); Michael Hassan Atighetchi (Framingham, Massachusetts); Zachary Ratliff (Somerville, Massachusetts) |
| ABSTRACT | Techniques for verifiable computation for cross-domain information sharing are disclosed. An untrusted node in a distributed cross-domain solution (CDS) system is configured to: receive a first data item and a first cryptographic proof associated with the first data item; perform a computation on the first data item including one or more of filtering, sanitizing, or validating the first data item, to obtain a second data item; generate, using a proof-carrying data (PCD) computation, a second cryptographic proof that indicates (a) validity of the first cryptographic proof and (b) integrity of the first computation on the first data item; and transmits the second data item and the second cryptographic proof to a recipient node in the distributed CDS system. Alternatively or additionally, the untrusted node may be configured to transmit a cryptographic proof to a trusted aggregator in the CDS system. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172825 |
| ART UNIT | 2438 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637815 | Hartley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARCHITECTURE TECHNOLOGY CORPORATION (Eden Prairie, Minnesota) |
| ASSIGNEE(S) | ARCHITECTURE TECHNOLOGY CORPORATION (Eden Prairie, Minnesota) |
| INVENTOR(S) | Timothy Hartley (Eden Prairie, Minnesota); Deborah Charan (Eden Prairie, Minnesota); Ranga S. Ramanujan (Eden Prairie, Minnesota) |
| ABSTRACT | Disclosed herein are embodiments of systems, methods, and products comprising a computing device, which provides Efficient Data-In-Transit Protection Techniques for Handheld Devices (EDITH) to protect data-in-transit. An end user device (EUD) may generate a multicast data packet. The EDITH module of the EUD encapsulates the data packet in a GRE packet and directs the GRE packet to a unicast destination address of an EDITH Multicast Router included in an infrastructure. The EDITH module on the EUD double compresses and double encrypts the GRE packet. The EDITH module on the infrastructure decrypts and decompresses the double compressed and double encrypted GRE packet to recreate the GRE packet. The EDITH module on the infrastructure decapsulates the GRE packet to derive the original multicast data packet, and distributes the original multicast data packet to the multiple group member based on the multicast destination address included in the original multicast data packet. |
| FILED | Tuesday, February 09, 2021 |
| APPL NO | 17/171436 |
| ART UNIT | 2416 — Multiplex and VoIP |
| CURRENT CPC | Electric Digital Data Processing G06F 21/602 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 45/16 (20130101) H04L 47/2441 (20130101) H04L 49/201 (20130101) H04L 63/0272 (20130101) H04L 63/0428 (20130101) Original (OR) Class H04L 69/04 (20130101) H04L 69/22 (20130101) Wireless Communication Networks H04W 4/06 (20130101) H04W 12/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637972 | Caulfield et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cyan Systems (Santa Barbara, California) |
| ASSIGNEE(S) | Cyan Systems (Santa Barbara, California) |
| INVENTOR(S) | John Caulfield (Santa Barbara, California); Jon Paul Curzan (Arroyo Grande, California) |
| ABSTRACT | A method that can detect targets is described. The method includes setting an integration time for each of a plurality of readout circuits based on a speed of the target. The readout circuits are configured to read pixels in an image detector. The pixels have a pitch of less than ten micrometers. The integration time is not more than five hundred microseconds and corresponds to a subframe of a fast frame image. The method also includes performing integrations of each readout circuit based on the integration time. Thus, a plurality of subframes are provided. A number of the subframes are averaged to provide the fast frame image. |
| FILED | Thursday, June 25, 2020 |
| APPL NO | 16/912606 |
| ART UNIT | 2696 — Selective Visual Display Systems |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/255 (20220101) Pictorial Communication, e.g Television H04N 5/33 (20130101) Original (OR) Class H04N 5/3535 (20130101) H04N 5/35572 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 11633299 | Kulstad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Cooling Therapy, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | Advanced Cooling Therapy, Inc. (Chicago, Illinois) |
| INVENTOR(S) | Erik Kulstad (Dallas, Texas); Hugh Patrick Caherty (Canton, Michigan) |
| ABSTRACT | Relatively non-invasive devices and methods for heating or cooling a patient's body are disclosed. Devices and methods for treating ischemic conditions by inducing therapeutic hypothermia are disclosed. Devices and methods for inducing therapeutic hypothermia through esophageal cooling are disclosed. Devices and methods for operative temperature management are disclosed. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 16/896075 |
| ART UNIT | 3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 2017/00084 (20130101) A61B 2090/064 (20160201) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/12 (20130101) Original (OR) Class A61F 7/123 (20130101) A61F 2007/0054 (20130101) A61F 2007/0095 (20130101) A61F 2007/126 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633784 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri) |
| INVENTOR(S) | Lianyi Chen (Rolla, Missouri); Minglei Qu (Rolla, Missouri) |
| ABSTRACT | A process for manufacturing metal-ceramic composite material powder comprising ball milling metal powder and ceramic nanoparticles to yield a metal-ceramic composite powder comprising ceramic nanoparticles embedded in a metal matrix powder particles; wherein the ball milling is performed using a ceramic milling media and a milling vessel having a ceramic interior surface. Metal matrix nanocomposite powders comprising ceramic nanoparticles imbedded in metal matrix powder particles; wherein the metal matrix powder particles have a spherical shape; wherein there is uniform distribution the ceramic nanoparticles; wherein the nanocomposite powders have good flowability. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 16/901879 |
| ART UNIT | 1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/065 (20220101) B22F 9/04 (20130101) Original (OR) Class B22F 2009/043 (20130101) B22F 2202/13 (20130101) B22F 2301/052 (20130101) B22F 2302/05 (20130101) B22F 2302/10 (20130101) B22F 2302/20 (20130101) B22F 2304/054 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633849 | Hawkes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Elliot Hawkes (Santa Barbara, California); Nicholas Naclerio (Portola Valley, California) |
| ABSTRACT | A soft robot includes a main body configured as a tube inverted back inside itself to define a pressure channel, such that when the channel is pressurized, the main body everts, and inverted material everts and passes out of a tip at a distal end of the main body. A fluidization tube for passing air or other fluid through a core of the main body in the fluidization tube, wherein the fluidization tube engages the main body such that the fluidization tube is ejected as the distal end as the main body everts and joins part of the side of the main body as the main body everts and extends its distal tip. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/277665 |
| ART UNIT | 3658 — Material and Article Handling |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/142 (20130101) Original (OR) Class B25J 18/06 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 7/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634429 | Elder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Delwin Elder (Seattle, Washington); Lewis Johnson (Seattle, Washington); Bruce Robinson (Seattle, Washington); Huajun Xu (Seattle, Washington) |
| ABSTRACT | Chromophores with large hyperpolarizabilities, films with electro-optic activity comprising the chromophores, and electro-optic devices comprising the chromophores are disclosed. |
| FILED | Monday, April 04, 2022 |
| APPL NO | 17/713055 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 307/28 (20130101) C07D 495/04 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0812 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3613 (20130101) G02F 1/3614 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0061 (20130101) H01L 51/0068 (20130101) H01L 51/0074 (20130101) H01L 51/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634738 | Reddy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Woods Hole Oceanographic Institution (Woods Hole, Massachusetts); Western Washington University (Bellingham, Washington); Marine Biological Laboratory (Woods Hole, Massachusetts) |
| ASSIGNEE(S) | Woods Hole Oceanographic Institution (Woods Hole, Massachusetts); Western Washington University (Bellingham, Washington); Marine Biological Laboratory (Woods Hole, Massachusetts) |
| INVENTOR(S) | Christopher M. Reddy (Woods Hole, Massachusetts); Gregory W. O'Neil (Bellingham, Wisconsin); Scott R. Lindell (Woods Hole, Massachusetts) |
| ABSTRACT | A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388298 |
| ART UNIT | 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 49/00 (20130101) Heterocyclic Compounds C07D 303/32 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/19 (20130101) C10L 1/185 (20130101) C10L 1/1802 (20130101) C10L 2200/0476 (20130101) C10L 2200/0484 (20130101) Fatty Acids From Fats, Oils or Waxes; Candles; Fats, Oils or Fatty Acids by Chemical Modification of Fats, Oils, or Fatty Acids Obtained Therefrom C11C 3/003 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) C12P 7/649 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634751 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 17/122321 |
| ART UNIT | 1675 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) C12Q 1/6855 (20130101) C12Q 2563/179 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635094 | Keplinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado (Denver, Colorado) |
| INVENTOR(S) | Christoph Matthias Keplinger (Gerlinger, Germany); Xingrui Wang (Stuttgart, Germany); Shane Karl Mitchell (Denver, Colorado) |
| ABSTRACT | High strain hydraulically amplified self-healing electrostatic transducers having increased maximum theoretical and practical strains are disclosed. In particular, the actuators include electrode configurations having a zipping front created by the attraction of the electrodes that is configured orthogonally to a strain axis along which the actuators. This configuration produces increased strains. In turn, various form factors for the actuator configuration are presented including an artificial circular muscle and a strain amplifying pulley system. Other actuator configurations are contemplated that include independent and opposed electrode pairs to create cyclic activation, hybrid electrode configurations, and use of strain limiting layers for controlled deflection of the actuator. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/117418 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1075 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 5/006 (20130101) Original (OR) Class F15B 15/103 (20130101) F15B 21/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635256 | Strongrich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Andrew Strongrich (West Lafayette, Indiana); Alina Alexeenko (West Lafayette, Indiana) |
| ABSTRACT | A system to monitor and control a lyophilization process using a wireless network is disclosed which includes one or more wireless pressure and gas temperature sensors adapted to provide pressure and gas temperature measurements of the ambient environment, a lyophilization chamber, wherein the one or more wireless pressure sensors are distributed in one or more lyophilization vial trays, a vacuum pump, adapted to change the pressure with the lyophilization chamber, a heat exchanger adapted to modify temperature within the lyophilization chamber, and a controller adapted to collect pressure and gas temperature data from the one or more wireless pressure and gas temperature sensors, calculate sublimation rate of a product to be lyophilized using the collected pressure and gas temperature data, and adjust one or both of pressure and temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/588929 |
| ART UNIT | 3753 — Fluid Handling and Dispensing |
| CURRENT CPC | Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 5/06 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635357 | Carter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SiMPore Inc. (West Henrietta, New York) |
| ASSIGNEE(S) | Simpore Inc. (West Henrietta, New York) |
| INVENTOR(S) | Jared A. Carter (Rochester, New York); Akash S. Patel (Burlington, Vermont); Cassandra R. Walinski (Scottsville, New York); James A. Roussie (Rochester, New York) |
| ABSTRACT | Provided are methods, devices, and kits for the isolation of extracellular vesicles using silicon nanomembranes. A method for EV isolation includes the steps of collecting a biofluid sample, contacting the biofluid sample with a pre-filtration membrane, thereby forming a first filtrate and a first retentate, optionally, washing the first retentate of the pre-filtration membrane, contacting the first filtrate from the pre-filtration membrane with a capture membrane, thereby forming a second filtrate and a second retentate, optionally, washing the second retentate, and eluting the second retentate from the capture membrane or lysing the second retentate to recover the contents. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/382505 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Separation B01D 61/027 (20130101) B01D 61/147 (20130101) B01D 65/08 (20130101) B01D 71/02 (20130101) B01D 71/022 (20130101) B01D 2317/025 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 2200/0647 (20130101) B01L 2300/0681 (20130101) B01L 2300/0896 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 1/4005 (20130101) Original (OR) Class G01N 2001/4016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635422 | Beaumont |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jacques Beaumont (Liverpool, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacques Beaumont (Liverpool, New York) |
| ABSTRACT | A method for time constant estimation includes generating a bound for a R=1/ |
| FILED | Wednesday, January 23, 2019 |
| APPL NO | 16/255180 |
| ART UNIT | 1671 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/002 (20130101) G01N 33/48728 (20130101) Original (OR) Class Electric Digital Data Processing G06F 17/13 (20130101) Computer Systems Based on Specific Computational Models G06N 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635436 | Wolf et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| INVENTOR(S) | Christian Wolf (Arlington, Virginia); Fathima Yushra Thanzeel (Washington, District of Columbia) |
| ABSTRACT | The present invention relates to compositions and methods for determining the absolute configuration of D/L-cysteine and/or the enantiomeric composition of cysteine and/or the concentration of total cysteine in a sample. Uses of the composition and method are also described. |
| FILED | Tuesday, April 24, 2018 |
| APPL NO | 16/608147 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 309/65 (20130101) C07C 309/73 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/33 (20130101) G01N 21/64 (20130101) G01N 33/52 (20130101) G01N 33/6815 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635607 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Ki-Hee Song (Evanston, Illinois); Cheng Sun (Evanston, Illinois); Hao F. Zhang (Evanston, Illinois) |
| ABSTRACT | A method of microscopy comprises collecting an emission light; symmetrically dispersing the collected emission light into a first order (“1st”) light and a negative first order (“−1st”) light using a grating; wherein the 1st light comprises spectral information and the −1st light comprises spectral information; capturing the 1st light and the −1st light using a camera, localizing the one or more light-emitting materials using localization information determined from both the first spectral image and the second spectral image; and determining spectral information from the one or more light-emitting materials using the first spectral image and/or the second spectral image; wherein the steps of localizing and obtaining are performed simultaneously. A spectrometer for a microscope comprises a dual-wedge prism (“DWP”) for receiving and spectrally dispersing a light beam, wherein the DWP comprises a first dispersive optical device and a second dispersive optical device adhered to each other. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323302 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 2021/6417 (20130101) G01N 2201/0638 (20130101) Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 21/16 (20130101) Original (OR) Class G02B 21/36 (20130101) G02B 21/367 (20130101) G02B 27/149 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635610 | Simpson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Garth Jason Simpson (West Lafayette, Indiana); James Ulcickas (West Lafayette, Indiana); Fengyuan Deng (Watertown, Massachusetts); Changqin Ding (West Lafayette, Indiana) |
| ABSTRACT | A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/322903 |
| ART UNIT | 2424 — Cable and Television |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/26 (20130101) G02B 21/367 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 5/005 (20130101) G06T 2207/10056 (20130101) G06T 2207/20212 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635975 | Sivakumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Raghupathy Sivakumar (Atlanta, Georgia); Uma Parthavi Moravapalle (Atlanta, Georgia) |
| ABSTRACT | A method for task mobilization is disclosed. The method may include a server receiving a plurality of user inputs from a desktop application. Each user input may correspond to a respective function performed by a user on the desktop application. The processor may identify the respective functions of the plurality of user inputs. Further, the method may include translating the respective functions into respective mobile view functions. Based on the respective mobile view functions, the processor may generate a mobile application and provide the mobile application to a mobile user device. |
| FILED | Tuesday, February 12, 2019 |
| APPL NO | 16/969036 |
| ART UNIT | 2179 — Graphical User Interface and Document Processing |
| CURRENT CPC | Electric Digital Data Processing G06F 9/451 (20180201) Original (OR) Class G06F 21/629 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/535 (20220501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636333 | Sidhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tesla, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Tesla, Inc. (Austin, Texas) |
| INVENTOR(S) | Harsimran Singh Sidhu (Fremont, California); Paras Jagdish Jain (Cupertino, California); Daniel Paden Tomasello (Los Altos Hills, California); Forrest Nelson Iandola (San Jose, California) |
| ABSTRACT | A model training and implementation pipeline trains models for individual embedded systems. The pipeline iterates through multiple models and estimates the performance of the models. During a model generation stage, the pipeline translates the description of the model together with the model parameters into an intermediate representation in a language that is compatible with a virtual machine. The intermediate representation is agnostic or independent to the configuration of the target platform. During a model performance estimation stage, the pipeline evaluates the performance of the models without training the models. Based on the analysis of the performance of the untrained models, a subset of models is selected. The selected models are then trained and the performance of the trained models are analyzed. Based on the analysis of the performance of the trained models, a single model is selected for deployment to the target platform. |
| FILED | Thursday, July 25, 2019 |
| APPL NO | 16/522411 |
| ART UNIT | 2193 — Interprocess Communication and Software Development |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) G05D 1/0214 (20130101) G05D 1/0221 (20130101) G05D 2201/0213 (20130101) Electric Digital Data Processing G06F 9/45533 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636346 | Linsley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | Brown University (Providence, Rhode Island) |
| INVENTOR(S) | Drew Linsley (Providence, Rhode Island); Junkyung Kim (London, United Kingdom); Thomas Serre (East Greenwich, Rhode Island); Alekh Karkada Ashok (Karnataka, India); Lakshmi Narasimhan Govindarajan (Providence, Rhode Island); Rex Gerry Liu (Providence, Rhode Island) |
| ABSTRACT | A method includes providing a computer system, the computer system including at least a processor and a memory, the memory including at least an operating system, executing a process in the memory, the process including providing a recurrent circuit model, and converting the recurrent circuit model into a recurrent neural network that can be fit with gradient descent. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 16/868392 |
| ART UNIT | 2631 — Digital Communications |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) G06N 3/084 (20130101) Original (OR) Class G06N 3/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636368 | Ye et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| INVENTOR(S) | Jianbo Ye (State College, Pennsylvania); Jia Li (State College, Pennsylvania); James Z. Wang (State College, Pennsylvania) |
| ABSTRACT | A method of improving quality of crowdsourced affective data based on agreement relationship between a plurality of annotators include receiving, by a processor, a collection of stimuli previously given affective labels by the plurality of annotators, executing, by a processor, an algorithm operative to perform the steps including constructing an agreement multigraph as a probabilistic model including a pair-wise status of agreement between the affective labels given by different ones of the plurality of annotators, learning the probabilistic model computationally using the crowdsourced affective data, identifying a reliability of each of the plurality of annotators based on the learned model, and adjusting the crowdsourced affective data by calculating the affective labels of each stimuli based on the identified reliability of each of the plurality of annotators, thereby improving the quality of the crowdsourced affective data. |
| FILED | Thursday, January 04, 2018 |
| APPL NO | 15/862458 |
| ART UNIT | 2488 — Recording and Compression |
| CURRENT CPC | Electric Digital Data Processing G06F 16/9024 (20190101) G06F 17/18 (20130101) Computer Systems Based on Specific Computational Models G06N 7/01 (20230101) Original (OR) Class Image or Video Recognition or Understanding G06V 40/10 (20220101) G06V 40/166 (20220101) G06V 40/174 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636671 | Fathi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pointivo, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | POINTIVO, INC. (Atlanta, Georgia) |
| INVENTOR(S) | Habib Fathi (Atlanta, Georgia); Daniel Ciprari (Atlanta, Georgia); William Wilkins (Suwanee, Georgia) |
| ABSTRACT | The present disclosure relates to improvements in systems and methods in acquiring images via imaging devices, where such imaging devices can be configured, in some implementations, with an unmanned aerial vehicle or other vehicle types, as well as being hand-held. Images are acquired from the imaging devices according to capture plans where useful information types about a structure of interest (or objects, items, etc.) can be derived from a structure image acquisition event. Images acquired from capture plans can be evaluated to generate improvements in capture plans for use in subsequent structure image acquisition events. Capture plans provided herein generate accurate information as to all or part of the structure of interest, where accuracy is in relation to the real-life structure incorporated in the acquired images. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/411392 |
| ART UNIT | 2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/123 (20130101) B64C 2201/126 (20130101) B64C 2201/127 (20130101) Electric Digital Data Processing G06F 30/23 (20200101) Image or Video Recognition or Understanding G06V 20/176 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636755 | Reuel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Skroot Laboratory, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | SKROOT LABOORATORY, INC. (Ames, Iowa) |
| INVENTOR(S) | Nigel F. Reuel (Ames, Iowa); Kyle Jackson (Winterset, Iowa); Charu Gupta (Ames, Iowa); Cameron Greenwalt (Kalamazoo, Michigan) |
| ABSTRACT | A system for reading at least one wireless resonant sensor includes a signal parameter measuring device, a reader housing, a computing device electrically connected to the signal parameter measuring device, and a plurality of reader antennas disposed within the reader housing and electrically connected to the signal parameter measuring device, wherein the plurality of reader antennas comprises a first reader antenna for signal output and a second reader antenna for signal input. The signal parameter measuring device is configured to sweep frequencies over a range of frequencies to acquire signal parameters for the wireless resonant sensor. The computing device is configured to determine changes in resonant frequency of the wireless resonator sensor based on the signal parameters. The reader housing may be sized and shaped for placement against a surface of a vessel in which a chemical or biological process is occurring. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322650 |
| ART UNIT | 2876 — Optics |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10356 (20130101) Transmission Systems for Measured Values, Control or Similar Signals G08C 17/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637243 | Holmes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Russell J. Holmes (Chanhassen, Minnesota); John David Myers-Bangsund (Minneapolis, Minnesota); Thomas Robert Fielitz (Midland, Michigan) |
| ABSTRACT | Self-organizing patterns with micrometer-scale feature sizes are promising for the large area fabrication of photonic devices and scattering layers in optoelectronics. Pattern formation would ideally occur in the active semiconductor to avoid the need for further processing steps. The present disclosure includes approaches to form period patterns in single layers of organic semiconductors by an annealing process. When heated, a crystallization front propagates across the film, producing a sinusoidal surface structure with wavelengths comparable to that of near-infrared light. These surface features form initially in the amorphous region within a micron of the crystal growth front, likely due to competition between crystal growth and surface mass transport. The pattern wavelength can be tuned by varying film thickness and annealing temperature, millimeter scale domain sizes are obtained. Aspects of the disclosure can be exploited for self-assembly of microstructured organic optoelectronic devices, for example. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 16/881196 |
| ART UNIT | 2897 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/006 (20130101) H01L 51/0014 (20130101) H01L 51/0026 (20130101) Original (OR) Class H01L 51/0054 (20130101) H01L 51/0058 (20130101) H01L 51/0072 (20130101) H01L 51/447 (20130101) H01L 51/5262 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/36 (20130101) H01S 5/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637355 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Xuan Zhang (St. Louis, Missouri); Lan Yang (St. Louis, Missouri); Weidong Cao (St. Louis, Missouri); Weijian Chen (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Xuan Zhang (St. Louis, Missouri); Lan Yang (St. Louis, Missouri); Weidong Cao (St. Louis, Missouri); Weijian Chen (St. Louis, Missouri) |
| ABSTRACT | An integrated circuit is disclosed. The integrated circuit includes a first resonator, a second resonator, and a coupling element. The first resonator has a first terminal and a second terminal, where the first resonator comprises a gain resistor, a gain capacitor, and a gain inductor in parallel and electrically coupling the first terminal with the second terminal. The second resonator has a third terminal and a fourth terminal, where the second resonator includes a loss resistor, a loss capacitor, and a loss inductor in parallel and electrically coupling the third terminal with the fourth terminal. The coupling element selectively couples the first terminal of the first resonator with the third terminal of the second resonator. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/446000 |
| ART UNIT | 2843 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/32 (20130101) H01P 1/36 (20130101) H01P 1/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 11633722 | Chong |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UChicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | Lina Chong (Westmont, Illinois) |
| ABSTRACT | Methods for producing a carbon-free, PGM-free support for PGM catalyst. The catalytic material comprises PGM metals disposed on a carbon-free support which is catalytic but free of PGM. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/039747 |
| ART UNIT | 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/185 (20130101) B01J 23/75 (20130101) B01J 23/462 (20130101) B01J 23/468 (20130101) Original (OR) Class B01J 23/8871 (20130101) B01J 31/1691 (20130101) B01J 35/006 (20130101) B01J 35/06 (20130101) B01J 35/0033 (20130101) B01J 37/08 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633784 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri) |
| INVENTOR(S) | Lianyi Chen (Rolla, Missouri); Minglei Qu (Rolla, Missouri) |
| ABSTRACT | A process for manufacturing metal-ceramic composite material powder comprising ball milling metal powder and ceramic nanoparticles to yield a metal-ceramic composite powder comprising ceramic nanoparticles embedded in a metal matrix powder particles; wherein the ball milling is performed using a ceramic milling media and a milling vessel having a ceramic interior surface. Metal matrix nanocomposite powders comprising ceramic nanoparticles imbedded in metal matrix powder particles; wherein the metal matrix powder particles have a spherical shape; wherein there is uniform distribution the ceramic nanoparticles; wherein the nanocomposite powders have good flowability. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 16/901879 |
| ART UNIT | 1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/065 (20220101) B22F 9/04 (20130101) Original (OR) Class B22F 2009/043 (20130101) B22F 2202/13 (20130101) B22F 2301/052 (20130101) B22F 2302/05 (20130101) B22F 2302/10 (20130101) B22F 2302/20 (20130101) B22F 2304/054 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633789 | Lara-Curzio et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Edgar Lara-Curzio (Oak Ridge, Tennessee); Corson L. Cramer (Oak Ridge, Tennessee); Amelia M. Elliott (Oak Ridge, Tennessee); Brian A. Fricke (Oak Ridge, Tennessee); Prashant K. Jain (Oak Ridge, Tennessee); Richard R. Lowden (Oak Ridge, Tennessee); Kashif Nawaz (Oak Ridge, Tennessee); Vivek M. Rao (Oak Ridge, Tennessee); Matthew J. Sandlin (Oak Ridge, Tennessee) |
| ABSTRACT | A method for fabricating heat exchangers using additive manufacturing technologies. Additive manufacturing enables the manufacture of heat exchangers with complex geometries and/or with internal and external integral surface features. Additive manufacture also facilitates the manufacture of heat exchangers with regional variations, such as changes in size, shape and surface features. In one embodiment, the present invention provides a heat exchanger with a helicoidal shape that provides axial elastic compliance. In one embodiment, the internal channel of the heat exchanger varies along its length. The internal channel may have a cross-sectional area that increases progressively from one end to the other. In one embodiment, the external shape of the tubular structure may be non-circular to optimize heat transfer with an external heat transfer fluid. In one embodiment, the present invention provides a heat pipe with an internal wicking structure formed as an integral part of the additive manufacturing process. |
| FILED | Tuesday, February 09, 2021 |
| APPL NO | 17/171323 |
| ART UNIT | 3726 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 5/10 (20130101) B22F 10/20 (20210101) Original (OR) Class B22F 2998/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/046 (20130101) F28D 15/0233 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2255/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633790 | Bhattad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carl Zeiss Industrial Metrology, LLC (North Maple Grove, Minnesota) |
| ASSIGNEE(S) | Carl Zeiss Industrial Metrology, LLC (North Maple Grove, Minnesota); UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Pradeep Bhattad (Knoxville, Tennessee); Paul Brackman (Knoxville, Tennessee); Curtis Frederick (Knoxville, Tennessee); Marcin B. Bauza (Plymouth, Minnesota); Edson Costa Santos (Oberkochen, Germany); Ryan Dehoff (Knoxville, Tennessee); Alex Plotkowski (Knoxville, Tennessee); Aleksandr Lisovich (Plymouth, Minnesota); Jason James Tenboer (Elk River, Minnesota) |
| ABSTRACT | An apparatus includes a control system that defines a test part having multiple features of multiple feature types. The control system controls an additive manufacturing (AM) machine to print multiple copies of the test part, with each copy being printed according to a respective set of values used as printing parameters. A measurement system obtains a computed tomography (CT) image of each of the copies of the test part. An analysis system, for each of the plurality of feature types, analyzes the CT images to identify a selected set of values for the printing parameters. The analysis system identifies a portion of the CT image related to a first feature and assesses its density based on an average grayscale value. The AM machine is then controlled to print production parts according to, for each feature type of the production parts, the selected set of values for the printing parameters. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/777598 |
| ART UNIT | 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/85 (20210101) Original (OR) Class B22F 12/90 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) Image Data Processing or Generation, in General G06T 7/0006 (20130101) G06T 7/337 (20170101) G06T 11/005 (20130101) G06T 2207/30144 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 30/18019 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11633806 | Reid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Robert S. Reid (Los Alamos, New Mexico); Morgan T. Biel (Los Alamos, New Mexico); Nicholas M. Diskerud (Ann Arbor, Michigan); Lindsey M. Gaspar (Los Alamos, New Mexico); Kyle B. Hammond (Los Alamos, New Mexico); Martin Ward (Austin, Texas) |
| ABSTRACT | A fill tool system that fills, seals, and inspects a heat pipe array, which includes one or more heat pipes with heat pipe working fluid. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076706 |
| ART UNIT | 3761 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 53/06 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/16 (20130101) B23K 26/123 (20130101) B23K 26/127 (20130101) Original (OR) Class Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/26 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49353 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634507 | Mao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| INVENTOR(S) | Chuanbin Mao (Norman, Oklahoma); Lin Wang (Norman, Oklahoma); Penghe Qiu (Norman, Oklahoma) |
| ABSTRACT | A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide. |
| FILED | Thursday, April 02, 2020 |
| APPL NO | 16/838798 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/39 (20130101) A61K 39/385 (20130101) A61K 2039/60 (20130101) A61K 2039/627 (20130101) A61K 2039/645 (20130101) A61K 2039/55561 (20130101) Peptides C07K 17/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634599 | Fenn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | David R. Fenn (Allison Park, Pennsylvania); Kurt G. Olson (Gibsonia, Pennsylvania); Reza M. Rock (Pittsburgh, Pennsylvania); Cynthia Kutchko (Pittsburgh, Pennsylvania); Susan F. Donaldson (Allison Park, Pennsylvania); Hao Sun (Allison Park, Pennsylvania) |
| ABSTRACT | Methods of printing a three-dimensional object using co-reactive components are disclosed. Thermosetting compositions for three-dimensional printing are also disclosed. |
| FILED | Wednesday, September 02, 2020 |
| APPL NO | 17/010039 |
| ART UNIT | 1763 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/02 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/10 (20130101) C08G 18/73 (20130101) C08G 18/325 (20130101) C08G 18/755 (20130101) C08G 18/792 (20130101) C08G 18/3225 (20130101) C08G 18/3228 (20130101) C08G 18/3234 (20130101) C08G 18/3821 (20130101) C08G 18/4854 (20130101) C08G 18/5024 (20130101) C08G 18/6685 (20130101) C08G 18/7893 (20130101) C08G 2150/50 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/03 (20130101) C09D 11/30 (20130101) C09D 11/38 (20130101) C09D 11/102 (20130101) Original (OR) Class C09D 175/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634699 | Clubb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Robert T. Clubb (Culver City, California); Brendan Rayhan Amer (Los Angeles, California); Janine Y. Fu (Rancho Palos Verdes, California); Scott McConnell (Los Angeles, California); Hung Ton-That (Manvel, Texas); Chungyu Chang (Seabrook, Texas) |
| ABSTRACT | Covalently cross-linked pilus polymers displayed on the cell surface of Gram-positive bacteria are assembled by class C sortase enzymes. These pilus-specific transpeptidases located on the bacterial membrane catalyze a two-step protein ligation reaction—first, cleaving the LPXTG motif of one pilin protomer to form an acyl-enzyme intermediate, and second, joining the terminal threonine to the nucleophilic lysine residue residing within the pilin motif of another pilin protomer. Informed by the high-resolution crystal structures of corynebacterial pilus-specific sortase (SrtA) and by developing structural variants of the sortase enzyme whose catalytic pocket has been unmasked by activating mutations, we have developed new reagents capable of forming isopeptide bonds in vitro. The reagents disclosed herein can catalyze ligation of isolated SpaA domains in vitro provide a facile and versatile new platform for protein engineering and bio-conjugation that has major implications for biotechnology. |
| FILED | Wednesday, May 01, 2019 |
| APPL NO | 17/052116 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 1/13 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635023 | Taylor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | HAMILTON SUNDSTRAND CORPORATION (Charlotte, North Carolina) |
| INVENTOR(S) | Stephen H. Taylor (East Hartford, Connecticut); Malcolm P. MacDonald (Bloomfield, Connecticut) |
| ABSTRACT | A CO2 bottoming cycle system includes a first compressor operatively connected to a first turbine through a first shaft. A first generator is operatively connected to the first shaft. A second compressor is fluidically connected to the first compressor. The second compressor is operatively connected to a second turbine through a second shaft. A second generator is operatively connected to the second shaft. The first turbine is fluidically connected to the second turbine. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/715156 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 15/10 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 6/18 (20130101) Original (OR) Class F02C 7/224 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2210/12 (20130101) F05D 2220/62 (20130101) F05D 2220/323 (20130101) F05D 2260/10 (20130101) F05D 2260/213 (20130101) F05D 2260/232 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635404 | Shaltry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Michael R. Shaltry (Idaho Falls, Idaho); Prabhat K. Tripathy (Idaho Falls, Idaho); David Estrada (Boise, Idaho) |
| ABSTRACT | Methods for manufacturing an electrochemical sensor include forming at least one electrode by printing at least one conductive ink on a surface of at least one substrate. The conductive ink may comprise, e.g., a platinum-group metal, another transition-group metal with a high-temperature melting point, a conductive ceramic material, glass-like carbon, or a combination thereof. The electrochemical sensor may be free of another material over the at least one electrode. An electrochemical sensor, formed according to such methods, may be configured for use in harsh environments (e.g., a molten salt environment). Electrodes of the electrochemical sensor comprise conductive material formed from a printed, conductive ink. In some embodiments, at least a portion of the electrochemical sensor is free of silver, gold, copper, silicon, and polymer materials, such portion being that which is to be exposed to the harsh environment during use of the electrochemical sensor. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 16/840102 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/30 (20130101) G01N 27/403 (20130101) G01N 27/3272 (20130101) Original (OR) Class G01N 33/205 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635406 | Burge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Scott R. Burge (Tempe, Arizona); Russell G. Burge (Mountain View, California); David A. Hoffman (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Burge (Tempe, Arizona); Russell G. Burge (Mountain View, California); David A. Hoffman (Tempe, Arizona) |
| ABSTRACT | A microbial sensor, system, and method that can be used to determine a chemical environment and/or substrate concentrations in anaerobic or aerobic environments, such as soils, sediments and ground waters, are disclosed. An exemplary system uses one or more (e.g., inert) measurement electrodes and a reference electrode. The reference electrode can include an electrode exposed to atmospheric oxygen (e.g., a cathode) or an electrode exposed to stable anaerobic or aerobic conditions. The exemplary microbial sensor system measures open-circuit voltage to characterize the chemical (oxidizing or reducing) environment and/or recovery voltage to measure substrate concentrations in the subsurface. |
| FILED | Tuesday, April 14, 2020 |
| APPL NO | 16/848038 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) G01N 27/4035 (20130101) G01N 27/4163 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636557 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| INVENTOR(S) | Honggang Wang (Clifton Park, New York); Manu Parashar (Seattle, Washington); Radhakrishnan Srinivasan (Duvall, Washington); Miaolei Shao (Altamont, New York); Shruti Dwarkanath Rao (Schenectady, New York); Juan Sanchez-Gasca (Glenville, New York) |
| ABSTRACT | A system for enhanced power system model validation is provided. The system includes a computing device including at least one processor in communication with at least one memory device. The at least one processor is programmed to store a plurality of models for a plurality of devices and a plurality of input files associated with the plurality of models, receive, from a user, a selection of model of the plurality of models to simulate, retrieve one or more input files of the plurality of input files, perform a model validity check on the selected model, if the selected model passed the model validity check, perform a model calibration on the selected model, and if the selected model passed the model calibration, perform a post evaluation on the selected model. |
| FILED | Tuesday, December 17, 2019 |
| APPL NO | 16/717474 |
| ART UNIT | 2119 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 30/18 (20200101) G06F 30/27 (20200101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636917 | Costello et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zachary Costello (Berkeley, California); Hector Garcia Martin (Oakland, California) |
| ABSTRACT | Disclosed herein are systems and methods for determining metabolic pathway dynamics using time series multiomics data. In one example, after receiving time series multiomics data comprising time-series metabolomics data associated a metabolic pathway and time-series proteomics data associated with the metabolic pathway, derivatives of the time series multiomics data can be determined. A machine learning model, representing a metabolic pathway dynamics model, can be trained using the time series multiomics data and the derivatives of the time series multiomics data, wherein the metabolic pathway dynamics model relates the time-series metabolomics data and time-series proteomics data to the derivatives of the time series multiomics data. The method can include simulating a virtual strain of the organism using the metabolic pathway dynamics model. |
| FILED | Thursday, June 28, 2018 |
| APPL NO | 16/022113 |
| ART UNIT | 2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6276 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/086 (20130101) G06N 3/126 (20130101) G06N 20/20 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/30 (20190201) Original (OR) Class G16B 40/00 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637341 | Chiang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Yet-Ming Chiang (Weston, Massachusetts); Andres Badel (Deerfield Beach, Florida); Fei Wang (Cambridge, Massachusetts) |
| ABSTRACT | Multi-phase electrochemical cells and related systems and methods are generally described. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175543 |
| ART UNIT | 1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/368 (20130101) H01M 4/663 (20130101) H01M 12/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637502 | Singh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Deere and Company (Moline, Illinois) |
| ASSIGNEE(S) | Deere and Company (Moline, Illinois) |
| INVENTOR(S) | Brij N. Singh (West Fargo, North Dakota); Tianjun Fu (Moline, Illinois); Zachary Wehri (Moline, Illinois) |
| ABSTRACT | A system and method for controlling a dual active bridge based DC/DC converter. A controller implements a startup control scheme and DC bus pre-charge routine to prevent damage to the converter upon startup. During startup of the converter, the startup control process can be used to prevent excessive phase-shift and the DC bus pre-charge routine adjusts the pulse width modulated duty cycle by increasing the dead time between signals, resulting in a decreased DC bus capacitor. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484823 |
| ART UNIT | 2838 — Electrical Circuits and Systems |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/32 (20130101) H02M 1/36 (20130101) H02M 3/33573 (20210501) H02M 3/33584 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637756 | Taft et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Jeffrey D. Taft (Washington, Pennsylvania); Sinan G. Aksoy (Seattle, Washington); Casey C. Neubauer (West Richland, Washington); Scott A. Upton (Richland, Washington) |
| ABSTRACT | This document describes systems and techniques for evaluating and improving distribution-grid data transportability. These systems and techniques allow engineers to quantify the data transportability of a communication system within or connected to a distribution grid, which represents an ability to transport in real-time telemetry from source locations (e.g., sensors in the distribution grid) to control mechanisms. Distribution engineers can use the sensor readings to perform grid analytics, control operating parameters, and operate protection systems. Distribution engineers can also use the transportability of the communication system to evaluate the observability of the distribution grid, which represents an ability to combine actual measurements and various types of computations (e.g., analytics, estimators, forecasters) from a system model. Distribution engineers can then generate a sensor allocation plan that indicates the number and location of sensors to maximize observability for a fixed sensor cost and/or minimize sensor cost for predetermined observability. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/339806 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/40 (20130101) G01R 31/086 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) Original (OR) Class H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 11633799 | Zaffetti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | HAMILTON SUNDSTRAND CORPORATION (Charlotte, North Carolina) |
| INVENTOR(S) | Mark A. Zaffetti (Suffield, Connecticut); Benjamin Abraham (Marlborough, Connecticut); Timothy Sauerhoefer (Broad Brook, Connecticut) |
| ABSTRACT | Systems and methods to control fabrication of an assembly involve a first end sheet having an interior surface and an exterior surface, opposite the interior surface. A system includes interior sheets, the interior sheets including a first interior sheet at one end of a stack of the interior sheets and including a last interior sheet at an opposite end of the stack of the two or more interior sheets, the first interior sheet being adjacent to the interior surface of the first end sheet, and a second end sheet having an interior surface and an exterior surface, opposite the interior surface. The last interior sheet is adjacent to the interior surface of the last end sheet, and the interior surface of the first end sheet or the second end sheet includes venting features, the venting features including holes or slots to channel heat, gas, or vapor during a brazing process. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/060359 |
| ART UNIT | 1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0012 (20130101) B23K 1/018 (20130101) Original (OR) Class B23K 2101/14 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634241 | Pawelski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CisLunar Industries USA, Inc. (Denver, Colorado) |
| ASSIGNEE(S) | CisLunar Industries USA, Inc. (Denver, Colorado) |
| INVENTOR(S) | Joseph W. Pawelski (Fort Collins, Colorado); Toby Joseph Daniel Mould (South Croydon, United Kingdom); Jan Walter Schroeder (Sötern, Germany); Gary Douglas Calnan (Denver, Colorado) |
| ABSTRACT | Certain embodiments of the inventive technology may be described as apparatus for melting and reshaping metal from a first shape into a second shape in a microgravity or zero gravity environment, such as a space foundry, where such apparatus includes feedstock input componentry (5) configured to accept conductive metal feedstock (7) having the first shape, a furnace and a furnace pre-stage (22) established upflow of the furnace, a plurality of electromagnetic field generators (10), each of which is configured to generate an electromagnetic field, to, e.g., steer, melt and/or move the metal, whether melt or otherwise, and casting componentry (15) configured to reshape molten metal to the second shape. Certain embodiments may achieve a high degree of control over electromagnetic fields by offering individual adjustment of one or more electrical parameters of the electromagnetic field generators (10). |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/737588 |
| ART UNIT | 1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/1078 (20130101) B64G 4/00 (20130101) Original (OR) Class Details or Accessories of Furnaces, Kilns, Ovens, or Retorts, in so Far as They Are of Kinds Occurring in More Than One Kind of Furnace F27D 3/14 (20130101) F27D 2003/0039 (20130101) F27D 2003/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635094 | Keplinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado (Denver, Colorado) |
| INVENTOR(S) | Christoph Matthias Keplinger (Gerlinger, Germany); Xingrui Wang (Stuttgart, Germany); Shane Karl Mitchell (Denver, Colorado) |
| ABSTRACT | High strain hydraulically amplified self-healing electrostatic transducers having increased maximum theoretical and practical strains are disclosed. In particular, the actuators include electrode configurations having a zipping front created by the attraction of the electrodes that is configured orthogonally to a strain axis along which the actuators. This configuration produces increased strains. In turn, various form factors for the actuator configuration are presented including an artificial circular muscle and a strain amplifying pulley system. Other actuator configurations are contemplated that include independent and opposed electrode pairs to create cyclic activation, hybrid electrode configurations, and use of strain limiting layers for controlled deflection of the actuator. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/117418 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1075 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 5/006 (20130101) Original (OR) Class F15B 15/103 (20130101) F15B 21/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11635107 | Hunsaker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of the National Aeronautics and Space (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dakota Hunsaker (Houston, Texas); Gabriel Ortiz-Sanchez (Houston, Texas) |
| ABSTRACT | A joint includes a shell that is hollow and at least partially spherical. The shell includes a plurality of shell rail sections including a first shell rail section. The first shell rail section includes a portion of an outer surface of the shell, a portion of an inner surface of the shell, and an opening edge section that defines a shell opening. The joint also includes a plurality of rotatable members including a first rotatable member. The first rotatable member includes an outer cup positioned at least partially outside of the shell and having an outer track surface, and an inner cup positioned at least partially inside of the shell and having an inner track surface. The first shell rail section is positioned at least partially between the outer and inner track surfaces. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237292 |
| ART UNIT | 3678 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 1/1906 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 11/0623 (20130101) F16C 11/0661 (20130101) Original (OR) Class F16C 11/0695 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11637469 | Cantemir et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); Olivia Bruj (Cluj, Romania) |
| ASSIGNEE(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| INVENTOR(S) | Codrin Cantemir (Columbus, Ohio); Olivia Bruj (Cluj, Romania) |
| ABSTRACT | An example method of producing an electric machine is described herein. The method can include providing the electric machine. The electric machine can include a rotor and a stator, where the stator includes a magnetic core and a stator winding. Additionally, the magnetic core can include a plurality of teeth defining a plurality of slots between adjacent teeth. The stator winding can also include a first portion arranged inside a slot and a second portion arranged outside the slot. The method can further include optimizing, using a computing device, a geometry of the first portion of the stator winding, where the first portion of the stator winding in the provided electric machine has the optimized geometry. |
| FILED | Wednesday, October 16, 2019 |
| APPL NO | 16/654829 |
| ART UNIT | 2148 — Electrical Circuits and Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 30/17 (20200101) G06F 2113/24 (20200101) G06F 2119/06 (20200101) Dynamo-electric Machines H02K 3/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 11632953 | Swale et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Daniel R. Swale (Zachary, Louisiana); Lane D. Foil (Baton Rouge, Louisiana) |
| ABSTRACT | Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or elimination in the ability of the arthropod to feed. Administering Kir channel inhibitors reduces food intake, increases feeding time, reduces salivary gland secretion, induces mortality, and reduces transmission of vector-borne pathogens. Kir channel inhibitors induce these adverse effects in ticks, mosquitoes, horn flies, and aphids. |
| FILED | Monday, November 13, 2017 |
| APPL NO | 16/348236 |
| ART UNIT | 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/38 (20130101) A01N 43/40 (20130101) Original (OR) Class A01N 43/56 (20130101) A01N 43/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634462 | Damodaran |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Srinivasan Damodaran (Middleton, Wisconsin) |
| ABSTRACT | Methods of processing protein, methods of generating products with the processed protein, and products comprising and/or made with the processed protein. The methods of processing protein include hydrolyzing the protein with a proteolytic agent such as thermolysin to generate hydrolyzed peptides and, optionally, crosslinking the hydrolyzed peptides with a transglutaminase to generate crosslinked peptides. The methods reduce the allergenicity of allergenicity proteins such as β-lactoglobulin and casein. The methods of generating products with the processed protein include methods of making foams, emulsions, and/or food products with the processed protein. The products comprising and/or made with the processed protein accordingly include foams, emulsions, and food products. The foams, emulsions, and food products have decreased allergenicity compared to corresponding products made with non-processed proteins. |
| FILED | Monday, May 20, 2019 |
| APPL NO | 16/416744 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/08 (20130101) Peptides C07K 14/47 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US PP35118 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by The Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Chunxian Chen (Byron, Georgia); William R. Okie (Augusta, Georgia) |
| ABSTRACT | A new and distinct cultivar of peach tree, denominated ‘May Joy’, has clingstone, melting, yellow-flesh fruit with normal acidity and pleasant eating quality. The fruit typically are round, ripen approximately 1-2 weeks before ‘Flavorich’ (syn. ‘Rich May’) and 2-3 weeks before ‘Carored’ in early to mid-May in Byron, Ga., and have a high percentage of red blush with an attractive yellow ground color. The tree is moderately vigorous and semi-spreading in growth habit, has self-fertile showy pink flowers, and regularly bears crops in absence of severe spring frost. This cultivar has a winter chilling requirement estimated at approximately 650 chill hours and is suited for medium to high chill areas. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880414 |
| ART UNIT | 1661 — Plants |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/7463 (20180501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 11633879 | Stoeckl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); The Trustees Of The University Of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Brendan D. Stoeckl (Philadelphia, Pennsylvania); Robert L. Mauck (Philadelphia, Pennsylvania); Hannah Zlotnick (Philadelphia, Pennsylvania); Megan Farrell (Philadelphia, Pennsylvania); Liane Miller (Philadelphia, Pennsylvania); David Steinberg (Philadelphia, Pennsylvania) |
| ABSTRACT | A method for forming a prosthesis comprising a bone-like portion and a cartilage-like portion can comprise additively manufacturing a first positive mold in accordance with a portion of a first three-dimensional model of a portion of a bone. A first negative mold can be formed from the first positive mold. The bone-like portion can be created within the first negative mold. A second positive mold of the bone and a cartilage can be additively manufactured from a second three-dimensional model. A portion of the second three-dimensional model can correspond to a portion of the first three-dimensional model. A second negative mold can be formed from the second positive mold. The bone-like portion can be positioned in the second negative mold so that the second negative mold and the bone-like portion can define a cartilage space that can be filled with a material to form the cartilage-like portion of the prosthesis. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152647 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/4261 (20130101) A61F 2/30942 (20130101) A61F 2002/4271 (20130101) A61F 2002/30948 (20130101) A61F 2002/30952 (20130101) A61F 2002/30953 (20130101) A61F 2002/30957 (20130101) A61F 2002/30985 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/26 (20130101) A61L 27/52 (20130101) A61L 2430/02 (20130101) A61L 2430/06 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/3842 (20130101) Original (OR) Class B29C 64/386 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2067/04 (20130101) B29K 2105/0061 (20130101) B29K 2883/00 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7532 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11634381 | Passaniti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United States of America as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United States of America as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Antonino Passaniti (White Hall, Maryland); Alexander D. MacKerell, Jr. (Baltimore, Maryland) |
| ABSTRACT | Provide herein are compounds with a general chemical structure of: Substituents R1 and R2 independently are H, Cl, F, Br, CH3, CF3, SH, —N(C1-3alkyl)2, —NHC(O)C1-3alkyl, or —NHC(O)C5-7cycloalkyl, substituent R3 is H or C1-3 alkyl and R4 is a bridged cycloalkene such as a bridged cyclohexene or a bridge-substituted cyclohexene. The compounds are therapeutics to treat a cancer, such as breast cancer, or metastatic cancers, to inhibit RUNX2 activity, such as protein expression, in a cancer cell and to increase survival of a subject with breast cancer. |
| FILED | Friday, May 03, 2019 |
| APPL NO | 16/402402 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/196 (20130101) A61K 31/196 (20130101) A61K 31/517 (20130101) A61K 31/517 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 235/82 (20130101) Original (OR) Class C07C 2601/14 (20170501) C07C 2602/42 (20170501) C07C 2603/94 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 11636328 | Ranjan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| INVENTOR(S) | Rajeev Ranjan (College Park, Maryland); Carlos Castillo (Silver Spring, Maryland); Ramalingam Chellappa (Potomac, Maryland) |
| ABSTRACT | Various face discrimination systems may benefit from techniques for providing increased accuracy. For example, certain discriminative face verification systems can benefit from L2-constrained softmax loss. A method can include applying an image of a face as an input to a deep convolutional neural network. The method can also include applying an output of a fully connected layer of the deep convolutional neural network to an L2-normalizing layer. The method can further include determining softmax loss based on an output of the L2-normalizing layer. |
| FILED | Wednesday, March 28, 2018 |
| APPL NO | 15/938898 |
| ART UNIT | 2636 — Optical Communications |
| CURRENT CPC | Electric Digital Data Processing G06F 17/11 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/627 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 5/046 (20130101) Image or Video Recognition or Understanding G06V 40/172 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11636372 | Inoue et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Ken Inoue (Elmsford, New York); Maika Takita (Croton-on-Hudson, New York); Antonio Corcoles-Gonzalez (Mount Kisco, New York); Scott Douglas Lekuch (New York, New York) |
| ABSTRACT | Systems, computer-implemented methods, and computer program products that can facilitate determining a state of a qubit are described. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise an output receiving component that can receive, in response to a request, output representative of a quantum state of a qubit of a quantum computing device, and a classifying component that classifies the quantum state of the qubit of the quantum computing device based on the output representative of the quantum state of the qubit. The system can further include a configuring component that can configure the classifying component based on a characteristic of the request. |
| FILED | Thursday, November 07, 2019 |
| APPL NO | 16/677178 |
| ART UNIT | 2851 — Printing/Measuring and Testing |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6269 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class G06N 10/20 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 11636344 | Savvides et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Marios Savvides (Pittsburgh, Pennsylvania); Dipan Kumar Pal (Pittsburgh, Pennsylvania) |
| ABSTRACT | During training of deep neural networks, a Copernican loss (LC) is designed to augment the standard Softmax loss to explicitly minimize intra-class variation and simultaneously maximize inter-class variation. Copernican loss operates using the cosine distance and thereby affects angles leading to a cosine embedding, which removes the disconnect between training and testing. |
| FILED | Tuesday, March 12, 2019 |
| APPL NO | 16/299498 |
| ART UNIT | 2122 — AI & Simulation/Modeling |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 11637214 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | Hewlett Packard Enterprise Development LP (Spring, Texas) |
| INVENTOR(S) | Zhihong Huang (Milpitas, California); Di Liang (Santa Barbara, California); Yuan Yuan (Milpitas, California) |
| ABSTRACT | A device may include: a highly doped n+ Si region; an intrinsic silicon multiplication region disposed on at least a portion of the n+ Si region, the intrinsic silicon multiplication having a thickness of about 90-110 nm; a highly doped p− Si charge region disposed on at least part of the intrinsic silicon multiplication region, the p− Si charge region having a thickness of about 40-60 nm; and a p+ Ge absorption region disposed on at least a portion of the p− Si charge region; wherein the p+ Ge absorption region is doped across its entire thickness. The thickness of the n+ Si region may be about 100 nm and the thickness of the p− Si charge region may be about 50 nm. The p+ Ge absorption region may confine the electric field to the multiplication region and the charge region to achieve a temperature stability of 4.2 mV/°C. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/664462 |
| ART UNIT | 2815 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1446 (20130101) H01L 31/028 (20130101) H01L 31/105 (20130101) Original (OR) Class H01L 31/1804 (20130101) Transmission H04B 10/66 (20130101) Multiplex Communication H04J 14/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 11636333 | Sidhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tesla, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Tesla, Inc. (Austin, Texas) |
| INVENTOR(S) | Harsimran Singh Sidhu (Fremont, California); Paras Jagdish Jain (Cupertino, California); Daniel Paden Tomasello (Los Altos Hills, California); Forrest Nelson Iandola (San Jose, California) |
| ABSTRACT | A model training and implementation pipeline trains models for individual embedded systems. The pipeline iterates through multiple models and estimates the performance of the models. During a model generation stage, the pipeline translates the description of the model together with the model parameters into an intermediate representation in a language that is compatible with a virtual machine. The intermediate representation is agnostic or independent to the configuration of the target platform. During a model performance estimation stage, the pipeline evaluates the performance of the models without training the models. Based on the analysis of the performance of the untrained models, a subset of models is selected. The selected models are then trained and the performance of the trained models are analyzed. Based on the analysis of the performance of the trained models, a single model is selected for deployment to the target platform. |
| FILED | Thursday, July 25, 2019 |
| APPL NO | 16/522411 |
| ART UNIT | 2193 — Interprocess Communication and Software Development |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) G05D 1/0214 (20130101) G05D 1/0221 (20130101) G05D 2201/0213 (20130101) Electric Digital Data Processing G06F 9/45533 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 11634738 | Reddy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Woods Hole Oceanographic Institution (Woods Hole, Massachusetts); Western Washington University (Bellingham, Washington); Marine Biological Laboratory (Woods Hole, Massachusetts) |
| ASSIGNEE(S) | Woods Hole Oceanographic Institution (Woods Hole, Massachusetts); Western Washington University (Bellingham, Washington); Marine Biological Laboratory (Woods Hole, Massachusetts) |
| INVENTOR(S) | Christopher M. Reddy (Woods Hole, Massachusetts); Gregory W. O'Neil (Bellingham, Wisconsin); Scott R. Lindell (Woods Hole, Massachusetts) |
| ABSTRACT | A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388298 |
| ART UNIT | 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 49/00 (20130101) Heterocyclic Compounds C07D 303/32 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/19 (20130101) C10L 1/185 (20130101) C10L 1/1802 (20130101) C10L 2200/0476 (20130101) C10L 2200/0484 (20130101) Fatty Acids From Fats, Oils or Waxes; Candles; Fats, Oils or Fatty Acids by Chemical Modification of Fats, Oils, or Fatty Acids Obtained Therefrom C11C 3/003 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) C12P 7/649 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 11637577 | Lomen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Brandt J. Lomen (Bedford, New Hampshire); Steven R. Grimes (Brookline, New Hampshire); Matthew Anderson (Mont Vernon, New Hampshire) |
| ABSTRACT | A method is provided for correlating signals. The method includes receiving a plurality of data vectors representing a plurality of signals. The method further includes determining, for each of the data vectors, a first set of correlation coefficients, where each of the correlation coefficients in the first set is based on a direct cross-correlation between each of the data vectors. The method further includes calculating an average of the first set of correlation coefficients, and determining, for each of the data vectors, a second set of correlation coefficients, where each of the correlation coefficients in the second set are based on an indirect cross-correlation between each of the data vectors and the average of the first set of correlation coefficients. The method further includes detecting a correlation between at least two of the data vectors based on the second set of correlation coefficients. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/584793 |
| ART UNIT | 2633 — Digital Communications |
| CURRENT CPC | Transmission H04B 1/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, April 25, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20230425.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page