FedInvent™ Patents

Patent Details for Tuesday, October 17, 2023

This page was updated on Wednesday, October 18, 2023 at 05:34 AM GMT

Department of Health and Human Services (HHS)

11785925 — Disease biomarkers and treatment methods related thereto

US 11785925	Ebert et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
INVENTOR(S)	Benjamin Levine Ebert (Boston, Massachusetts); Jan Krönke (Boston, Massachusetts); Steven A. Carr (Cambridge, Massachusetts); Namrata D. Udeshi (Cambridge, Massachusetts); Emma Fink (Boston, Massachusetts)
ABSTRACT	The present invention features a knock-in mouse comprising a mutation in an endogenous CRBN locus and methods of use thereof.
FILED	Friday, May 10, 2019
APPL NO	16/408792
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Original (OR) Class A01K 2217/072 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) G01N 33/5011 (20130101) G01N 33/5088 (20130101) G01N 33/57496 (20130101) G01N 2333/47 (20130101)
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11786117 — Mobile device application for ocular misalignment measurement

US 11786117	Tomasi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Massachusetts Eye and Ear Infirmary (Boston, Massachusetts)
ASSIGNEE(S)	Massachusetts Eye and Ear Infirmary (Boston, Massachusetts)
INVENTOR(S)	Matteo Tomasi (Boston, Massachusetts); Shrinivas Pundlik (Boston, Massachusetts); Kevin Edward Houston (Norwell, Massachusetts); Gang Luo (Lexington, Massachusetts)
ABSTRACT	Disclosed are a mobile device and method which include acquiring, by an image acquisition unit installed in a mobile device, an image of eyes of a patient while light provided by a light source reflects from an optical surface of the eyes of the patient; and obtaining, by a processor installed in the mobile device, ocular misalignment measurements, including a magnitude and a direction of ocular misalignment in the eyes of the patient, using the acquired image or set of images.
FILED	Thursday, October 29, 2020
APPL NO	17/084412
ART UNIT	2872 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/00 (20130101) A61B 3/08 (20130101) A61B 3/10 (20130101) A61B 3/14 (20130101) A61B 3/085 (20130101) Original (OR) Class A61B 3/152 (20130101) Image or Video Recognition or Understanding G06V 10/17 (20220101) G06V 10/141 (20220101) G06V 10/147 (20220101) G06V 40/19 (20220101) G06V 40/67 (20220101) G06V 40/193 (20220101)
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11786132 — Systems and methods for predicting arousal to consciousness during general anesthesia and sedation

US 11786132	Purdon et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Patrick L. Purdon (Somerville, Massachusetts); Oluwaseun Akeju (Dorchester, Massachusetts); Emery N. Brown (Brookline, Massachusetts)
ABSTRACT	A system and method for monitoring a patient suspected of experiencing a state of unconsciousness are provided. In certain aspects, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality of electroencephalogram signals, and determining, from the plurality of electroencephalogram signals, at least one of frequency information and amplitude information. The method can also include identifying, using the at least one of the frequency information and the amplitude information, spatiotemporal signatures indicative of a likelihood of arousing the patient to consciousness by applying an external stimulus and generating a report indicating the likelihood of arousing the patient to consciousness by applying the external stimulus.
FILED	Friday, October 18, 2019
APPL NO	16/657194
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/02 (20130101) A61B 5/38 (20210101) A61B 5/0205 (20130101) Original (OR) Class A61B 5/369 (20210101) A61B 5/374 (20210101) A61B 5/4821 (20130101) A61B 5/7264 (20130101) A61B 5/7275 (20130101) Electric Digital Data Processing G06F 2218/00 (20230101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101)
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11786150 — Wired implantable monolithic integrated sensor circuit

US 11786150	Mujeeb-U-Rahman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	INTEGRATED MEDICAL SENSORS, INC. (Irvine, California)
ASSIGNEE(S)
INVENTOR(S)	Muhammad Mujeeb-U-Rahman (Irvine, California); Meisam Honarvar Nazari (Irvine, California); Mehmet Sencan (Tustin, California)
ABSTRACT	There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (1) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.
FILED	Thursday, September 01, 2022
APPL NO	17/993516
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/6848 (20130101) A61B 5/14532 (20130101) Original (OR) Class A61B 5/14865 (20130101)
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11786174 — System and method to maintain health using personal digital phenotypes

US 11786174	Narayan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Sanjiv M. Narayan (Palo Alto, California); Mahmood Alhusseini (Palo Alto, California)
ABSTRACT	A system and method for identifying and treating a disease in a patient collects one or more data streams from sensors configured to detect biological signals generated within a patient's tissue over time. Patient data elements including one or more of demographic, clinical, laboratory, pathology, chemical, image, historical, genetic, and activity data for the patient is collected and processed with the data streams to generate a personalized digital phenotype (PDP). The PDP is compared to a digital taxonomy comprising prior data to classify the patient into one or more quantitative disease classifications to guide personalized intervention for treating the patient.
FILED	Wednesday, April 24, 2019
APPL NO	17/051749
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/024 (20130101) A61B 5/361 (20210101) A61B 5/363 (20210101) A61B 5/0816 (20130101) A61B 5/4836 (20130101) Original (OR) Class A61B 5/7246 (20130101) A61B 5/7264 (20130101) A61B 2562/0204 (20130101) A61B 2562/0219 (20130101) A61B 2562/0238 (20130101) A61B 2562/0271 (20130101)
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11786215 — Methods of detecting, measuring, or imaging a concentration or location of a therapeutic agent

US 11786215	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	Hong Chen (St. Louis, Missouri); Yaoheng Yang (St. Louis, Missouri); Jeffrey Williamson (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Hong Chen (St. Louis, Missouri); Yaoheng Yang (St. Louis, Missouri); Jeffrey Williamson (St. Louis, Missouri)
ABSTRACT	Systems and methods for monitoring and controlling delivery of a therapeutic compound to a brain of a subject using FUS-BBBD are disclosed. The method includes treating the brain of the subject with focused ultrasound in combination with microbubbles for blood-brain barrier disruption (FUS-BBBD), administering the therapeutic agent to the subject; and obtaining a map of a concentration of the therapeutic agent delivered to the brain of the subject using passive cavitation imaging (PCI). The delivery of focused sound may be modulated to match the map of the concentration of the therapeutic agent delivered to the brain of the subject to a desired spatial distribution of the therapeutic agent.
FILED	Thursday, January 23, 2020
APPL NO	16/751197
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/481 (20130101) Original (OR) Class A61B 8/0808 (20130101) A61B 8/5207 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) A61N 2007/0039 (20130101)
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11786218 — Burst ultrasound reconstruction with signal templates and related methods and systems

US 11786218	Sawyer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Daniel P. Sawyer (Pasadena, California); Arash Farhadi (Pasadena, California); Avinoam D. Bar-Zion (Pasadena, California); Mikhail Shapiro (Pasadena, California)
ABSTRACT	The application of a step function increase in acoustic pressure during ultrasound imaging using gas vesicle contrast, along with capturing successive frames of ultrasound imaging and extracting time-series vectors for pixels of the frames, allows for improved imaging down to even the cell level. Template vectors can be used to implement signal separation of the time-series vectors to improve detection.
FILED	Tuesday, January 07, 2020
APPL NO	16/736581
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/481 (20130101) A61B 8/5207 (20130101) Original (OR) Class A61B 8/5246 (20130101)
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11786418 — Modular medical mobility device

US 11786418	Aceros et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	Juan Aceros (St. Johns, Florida); Matthew Cantwell (Orange Park, Florida); John Prisco (Holly Springs, Georgia)
ASSIGNEE(S)	University of North Florida Board of Trustees (Jacksonville, Florida)
INVENTOR(S)	Juan Aceros (St. Johns, Florida); Matthew Cantwell (Orange Park, Florida); John Prisco (Holly Springs, Georgia)
ABSTRACT	A modular ride-on is provided that is adjustable based on the needs of the operator. The modular ride-on offers children and young adults with disabilities a higher degree of freedom and comfort over traditional mobility devices—such as wheelchairs. The modular ride-on includes a chassis configured to removably couple a plurality of adjustable modules. The independently adjustable modules include a front-end module, first and second drive modules, a seating module, a harness module, an armrest module, a footrest module, a leg support, module, a body module, and a control module.
FILED	Tuesday, December 08, 2020
APPL NO	17/247346
ART UNIT	3618 — Recording and Compression
CURRENT CPC	Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/10 (20130101) A61G 5/041 (20130101) Original (OR) Class A61G 5/1056 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0003 (20140204) A61M 16/1005 (20140204) A61M 2209/082 (20130101) Vehicle Connections B60D 1/01 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/60 (20190201) B60L 2200/24 (20130101)
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11786457 — Peritumoral and intratumoral materials for cancer therapy

US 11786457	Koshy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Sandeep T. Koshy (Boston, Massachusetts); David J. Mooney (Sudbury, Massachusetts)
ABSTRACT	The invention provides methods and compositions for reducing tumor-mediated immune evasion and inducing patient-specific immunization.
FILED	Friday, January 29, 2016
APPL NO	15/546852
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 9/0024 (20130101) Original (OR) Class A61K 31/704 (20130101) A61K 31/704 (20130101) A61K 31/4725 (20130101) A61K 31/4725 (20130101) A61K 31/4745 (20130101) A61K 31/4745 (20130101) A61K 38/08 (20130101) A61K 38/19 (20130101) A61K 38/19 (20130101) A61K 38/193 (20130101) A61K 39/39 (20130101) A61K 47/36 (20130101) A61K 47/42 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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11786464 — PH responsive block copolymer compositions and micelles that inhibit MCT 1 and related proteins

US 11786464	Gao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Board of Regents of the University of Texas System (Austin, Texas)
ASSIGNEE(S)	The Board of Regents of The University of Texas System (Austin, Texas)
INVENTOR(S)	Jinming Gao (Dallas, Texas); Tongyi Huang (Dallas, Texas); Qiang Feng (Allen, Texas); Baran Sumer (Dallas, Texas)
ABSTRACT	Described herein are therapeutic pH responsive compositions comprising a block copolymer and a therapeutic agent useful for the treatment of cancer.
FILED	Monday, April 26, 2021
APPL NO	17/239742
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/5025 (20130101) A61K 45/06 (20130101) A61K 47/32 (20130101) A61K 47/34 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101)
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11786489 — Ovarian cancer vaccines

US 11786489	Tuohy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Cleveland Clinic Foundation (Cleveland, Ohio)
ASSIGNEE(S)	The Cleveland Clinic Foundation (Cleveland, Ohio)
INVENTOR(S)	Vincent K. Tuohy (Broadview Heights, Ohio); Suparna Mazumder (Olmsted Falls, Ohio); Justin M. Johnson (Willoughby Hills, Ohio)
ABSTRACT	Provided herein are methods, kits and compositions for the treatment and/or prevention of ovarian cancer through the induction of an immune response against Anti-Mullerian Hormone Receptor, Type II (AMHR2).
FILED	Tuesday, August 17, 2021
APPL NO	17/404025
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/138 (20130101) Original (OR) Class A61K 31/337 (20130101) A61K 31/502 (20130101) A61K 31/555 (20130101) A61K 31/555 (20130101) A61K 31/675 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/704 (20130101) A61K 31/4196 (20130101) A61K 31/4745 (20130101) A61K 31/4985 (20130101) A61K 31/4985 (20130101) A61K 31/7048 (20130101) A61K 31/7048 (20130101) A61K 31/7064 (20130101) A61K 31/7064 (20130101) A61K 31/7068 (20130101) A61K 31/7068 (20130101) A61K 33/24 (20130101) A61K 33/243 (20190101) A61K 33/244 (20190101) A61K 39/001102 (20180801) A61K 45/06 (20130101) A61K 2039/575 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101)
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11786507 — Methods of treating HIV-associated neurological disorders (HAND)

US 11786507	He et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Rosalind Franklin University of Medicine and Science (Chicago, Illinois)
ASSIGNEE(S)	Rosalind Franklin University of Medicine and Science (North Chicago, Illinois)
INVENTOR(S)	Johnny He (North Chicago, Illinois); Xiaojie Zhao (North Chicago, Illinois)
ABSTRACT	In the present disclosure, doxycycline-inducible astrocyte-specific HIV Tat transgenic mice (iTat), a surrogate HAND model, were treated with PNU-125096, a positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR) and effects on Tat-induced behavioral impairments and neuropathologies were observed. This disclosure shows that PNU-125096 treatment significantly improved locomotor, learning and memory deficits of iTat mice while inhibited glial activation and increased PSD-95 expression in the cortex and hippocampus of iTat mice. α7 nAChR knockout eliminated the protective effects of PNU-125096 on iTat mice. In addition, inhibition of p38 phosphorylation by SB239063, a p38 MAPK-specific inhibitor, exacerbated Tat neurotoxicity in iTat mice. These findings demonstrated for the first time that α7 nAChR activation led to protection against HAND and suggest that α7 nAChR and PNU-125096 hold significant promise for development of therapeutics for HAND.
FILED	Friday, December 10, 2021
APPL NO	17/547472
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101)
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11786511 — Methods for increasing circulating mesenchymal stem cells

US 11786511	Gaffney et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Minority Health and Health Disparities (NIMHD)
APPLICANT(S)	Kevin J. Gaffney (Los Angeles, California); Kathleen E. Rodgers (Los Angeles, California); Maira Soto (Los Angeles, California); Michael Weinberg (Los Angeles, California)
ASSIGNEE(S)	University of Southern California (Los Angeles, California)
INVENTOR(S)	Kevin J. Gaffney (Los Angeles, California); Kathleen E. Rodgers (Los Angeles, California); Maira Soto (Los Angeles, California); Michael Weinberg (Los Angeles, California)
ABSTRACT	Disclosed herein are methods for increasing circulating mesenchymal stem cells by administering a compound having the general formula 1 as defined herein, or a pharmaceutically acceptable salt thereof.
FILED	Thursday, August 09, 2018
APPL NO	16/638000
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101)
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11786520 — Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition

US 11786520	Cox et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Sistema Universitario Ana G. Mendez, Inc. (San Juan, Puerto Rico)
ASSIGNEE(S)
INVENTOR(S)	Osvaldo Cox (Humacao, Puerto Rico); Beatriz Zayas (San Juan, Puerto Rico)
ABSTRACT	A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and nitro-substituent resulting in several compounds is provided. The compounds are further used as markers due to their fluorescent properties including in hypoxic environments. Furthermore, anti-cancer screening of two BQS, namely, 7-benzyl-3-aminobenzimidazo[3,2-a]quinolinium chloride (ABQ-48: NSC D-763307) and the corresponding 7-benzyl-3-nitrobenzimidazo[3,2-a]quinolinium chloride (NBQ 48: NSC D-763303) are provided.
FILED	Wednesday, June 09, 2021
APPL NO	17/343503
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4745 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101)
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11786543 — Compositions comprising decitabine and tetrahydrouridine and uses thereof

US 11786543	Desimone et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Joseph Desimone (Glen Ellyn, Illinois); Yogen Saunthararajah (Cleveland, Ohio)
ABSTRACT	Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly.
FILED	Wednesday, July 14, 2021
APPL NO	17/375585
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7068 (20130101) Original (OR) Class A61K 31/7068 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101)
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11786545 — Compositions and methods for treating SARS-CoV-2 infection

US 11786545	Pyle et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)	Yale University (New Haven, Connecticut)
INVENTOR(S)	Anna Marie Pyle (Guilford, Connecticut); Akiko Iwasaki (Guilford, Connecticut); Tianyang Mao (New Haven, Connecticut)
ABSTRACT	The present disclosure provides small hairpin nucleic acid molecules capable of stimulating interferon production. The nucleic acid molecules of the present disclosure has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises at least one 5′-triphosphate and/or at least one 5′-diphosphate. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection, and/or ameliorating, minimizing, reversing, and/or preventing persistent SARS-CoV-2 viral infection, and/or minimizing or preventing SARS-CoV-2 viral infection-derived mortality and/or lethality, in a subject. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection in a tumor-bearing subject. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection in an immune-compromised and/or immunodeficient subject.
FILED	Wednesday, March 30, 2022
APPL NO	17/709275
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101)
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11786551 — Methods for treating heart disease via redirected T cell immunotherapies

US 11786551	Epstein et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Jonathan Epstein (Radnor, Pennsylvania); Haig Aghajanian (Lafayette Hill, Pennsylvania); Steven M. Albelda (Philadelphia, Pennsylvania); Ellen Puré (Bryn Mawr, Pennsylvania)
ABSTRACT	The present invention includes compositions and methods for treating heart disease and/or heart failure. In one embodiment, the treatment includes administering to the subject a cell genetically modified to express a chimeric antigen receptor (CAR), comprising an antigen binding domain specific for fibroblast activation protein (FAP). In another embodiment, the treatment includes administering a cell genetically modified to express a T cell receptor (TCR) specific for an activated fibroblast.
FILED	Tuesday, September 25, 2018
APPL NO	16/651144
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) Peptides C07K 16/40 (20130101)
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11786557 — Luteinizing hormone receptor binding agents and luteinizing hormone agonists to identify, expand, ablate and modify stem cells

US 11786557	Dudakov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Fred Hutchinson Cancer Center (Seattle, Washington); Memorial Sloan Kettering Cancer Center (New York, New York)
ASSIGNEE(S)	Fred Hutchinson Cancer Center (Seattle, Washington)
INVENTOR(S)	Jarrod Dudakov (Seattle, Washington); Marcel van den Brink (New York, New York); Enrico Velardi (New York, New York); Hans-Peter Kiem (Seattle, Washington); Stefan Radtke (Seattle, Washington); Scott James (New York, New York)
ABSTRACT	The use of luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to enrich for primitive hematopoietic stem cell (pHSC) populations, to target pHSC for ablation, and/or to expand pHSC populations are described. The methods can be used to prepare therapeutic hematopoietic stem cell (HSC) populations, to prepare patients for therapeutic HSC transplants, and/or to treat malignancies, such as those associated with hyperproliferative HSC.
FILED	Tuesday, October 02, 2018
APPL NO	16/753277
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/28 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 15/86 (20130101)
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11786558 — Methods of cell therapies

US 11786558	Woods et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Ossium Health, Inc. (San Francisco, California)
ASSIGNEE(S)	Ossium Health, Inc. (San Francisco, California)
INVENTOR(S)	Erik J. Woods (Carmel, Indiana); Brian H. Johnstone (Fishers, Indiana); Dongsheng Gu (Indianapolis, Indiana); Aubrey Marie Sherry (Carmel, Indiana); Kelsey Gwen Musall (Avon, Indiana); Megan Sykes (New York, New York); Tomoaki Kato (New York, New York); Jianing Fu (New York, New York)
ABSTRACT	Described herein are methods of cell therapies. Also described herein are methods of generating donor derived T cells in an organ transplant recipient, by administering bone marrow stem cells to the organ transplant recipient about 1 to about 30 days after the organ transplant recipient receives one or more organ transplants.
FILED	Wednesday, March 16, 2022
APPL NO	17/696779
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 35/17 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 35/38 (20130101) A61K 38/1774 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0647 (20130101)
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11786565 — Strains of Lactobacillus delbrueckii which inhibit Porphyromonas gingivalis

US 11786565	Hu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Trustees of Tufts College (Boston, Massachusetts)
ASSIGNEE(S)	Trustees of Tufts College (Boston, Massachusetts)
INVENTOR(S)	Linden Hu (Sharon, Massachusetts); Louis Cornacchione (Cambridge, Massachusetts)
ABSTRACT	Disclosed herein are compositions and methods for treating periodontal disease.
FILED	Wednesday, March 18, 2020
APPL NO	17/440747
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 35/744 (20130101) Original (OR) Class A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501)
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11786580 — VIP and VIP agonists, nanoparticles, and uses in inflammatory T-cell mediated disease

US 11786580	Waller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Emory University (Atlanta, Georgia)
ASSIGNEE(S)	Emory University (Atlanta, Georgia)
INVENTOR(S)	Giacomo Waller (Atlanta, Georgia); Yiwen Li (Atlanta, Georgia); Edmund Waller (Atlanta, Georgia)
ABSTRACT	In certain embodiments, this disclosure relates to VIP and VIP agonists, optionally conjugated to nanoparticles, for use in methods of treating inflammatory T cell-mediated diseases or conditions, e.g., treating or preventing GvHD. In certain embodiments, this disclosure relates to methods of pulmonary administration of VIP and VIP agonists, optionally conjugated to nanoparticles. In certain embodiments, this disclosure contemplates nanoparticles disclosed herein.
FILED	Tuesday, April 23, 2019
APPL NO	17/050348
ART UNIT	1616 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0075 (20130101) A61K 9/124 (20130101) A61K 38/26 (20130101) Original (OR) Class A61K 47/24 (20130101) A61K 47/6935 (20170801)
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11786589 — Human rotavirus strains and vaccines

US 11786589	Jiang et al.
FUNDED BY	Department of Health and Human Services (HHS) Centers for Disease Control and Prevention (CDC)
APPLICANT(S)	THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Baoming Jiang (Duluth, Georgia); Roger I. Glass (Atlanta, Georgia); Yuhuan Wang (Liburn, Georgia); Jon Gentsch (Atlanta, Georgia)
ABSTRACT	A vaccine composition and method of vaccination are provided useful for immunizing a subject against a rotavirus. The vaccines include rotavirus strains CDC-9 and CDC-66, fragments thereof, homologues thereof, or combinations thereof. Inventive vaccines may include a fragment of CDC-9, CDC-66, homologues thereof, or combinations thereof. Methods of inducing an immunological response are provided by administering an inventive vaccine.
FILED	Wednesday, June 16, 2021
APPL NO	17/349639
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/15 (20130101) Original (OR) Class A61K 2039/54 (20130101) A61K 2039/545 (20130101) A61K 2039/5252 (20130101) A61K 2039/5254 (20130101) A61K 2039/55505 (20130101) Peptides C07K 14/005 (20130101) C07K 16/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2720/12334 (20130101) C12N 2720/12361 (20130101)
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11786591 — Recombinant metapneumovirus F proteins and their use

US 11786591	Kwong et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); Institute for Research in Biomedicine (Bellinzona, Switzerland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); Institute for Research in Biomedicine (Bellinzona, Switzerland)
INVENTOR(S)	Peter Kwong (Washington, District of Columbia); Michael Gordon Joyce (Washington, District of Columbia); Baoshan Zhang (Bethesda, Maryland); Yongping Yang (Potomac, Maryland); Peter Collins (Kensington, Maryland); Ursula Buchholz (Silver Spring, Maryland); Davide Corti (Bellinzona, Switzerland); Antonio Lanzavecchia (Bellinzona, Switzerland); Guillaume Stewart-Jones (Cambridge, Massachusetts)
ABSTRACT	Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
FILED	Friday, May 28, 2021
APPL NO	17/334505
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/155 (20130101) Original (OR) Class A61K 48/00 (20130101) Peptides C07K 14/005 (20130101) C07K 14/135 (20130101) C07K 2319/70 (20130101) C07K 2319/73 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18322 (20130101) C12N 2760/18334 (20130101) C12N 2760/18522 (20130101) C12N 2760/18534 (20130101)
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11786635 — Extracellular matrix for treating pelvic floor disorders and skeletal muscle degeneration

US 11786635	Christman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Karen Christman (San Diego, California); Marianna Alperin (La Jolla, California); Pamela Duran (San Diego, California)
ABSTRACT	Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases associated with muscular degeneration, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
FILED	Monday, June 06, 2022
APPL NO	17/833658
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/58 (20130101) A61L 27/367 (20130101) A61L 27/3633 (20130101) Original (OR) Class A61L 27/3683 (20130101) A61L 2400/06 (20130101) A61L 2430/30 (20130101)
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11786639 — Promoting endothelial cell affinity and antithrombogenicity of polytetrafluoroethylene (PTFE) by mussel-inspired modification and RGD/heparin grafting

US 11786639	Turng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Lih-Sheng Turng (Madison, Wisconsin); Hao-yang Mi (Madison, Wisconsin)
ABSTRACT	Disclosed herein are methods for modifying a substrate having a hydrophobic surface. Also disclosed are modified hydrophobic substrates. The modified hydrophobic substrates and methods disclosed herein advantageously improve cell affinity and antithrombogenicity of hydrophobic surfaces.
FILED	Monday, September 26, 2022
APPL NO	17/935300
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2310/00389 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/507 (20130101) Original (OR) Class A61L 33/0023 (20130101) A61L 2300/42 (20130101) Compositions of Macromolecular Compounds C08L 67/02 (20130101)
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11786680 — Integrated diagnostic and therapeutic system and method for improving treatment of subject with complex and central sleep apnea

US 11786680	Kayyali et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Cleveland Medical Devices Inc. (Cleveland, Ohio)
ASSIGNEE(S)	Cleveland Medical Devices Inc. (Cleveland, Ohio)
INVENTOR(S)	Hani Kayyali (Shaker Heights, Ohio); Daniel Bishop (Tallmadge, Ohio); Brian M. Kolkowski (Leroy, Ohio)
ABSTRACT	The present invention relates to an integrated sleep diagnosis and treatment device, and more particularly to an integrated apnea diagnosis and treatment device. The present invention additionally relates to methods of sleep diagnosis and treatment. The sleep disorder treatment system of the present invention can use a diagnosis device to perform various forms of analysis to determine or diagnose a subject's sleeping disorder or symptoms of a subject's sleep disorder, and using this analysis or diagnosis can with or in some embodiments without human intervention treat the subject either physically or chemically to improve the sleeping disorder or the symptoms of the sleeping disorder. The diagnostic part of the system can use many different types of sensors and methods for diagnosing the severity of the symptoms of or the sleep disorder itself. The treatment part of the system can use a device to physically or chemically treat the subject's symptoms or sleep disorder itself.
FILED	Friday, October 11, 2019
APPL NO	16/599410
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0013 (20130101) A61B 5/0077 (20130101) A61B 5/1135 (20130101) A61B 5/4818 (20130101) A61B 5/14552 (20130101) A61B 2560/0443 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/12 (20130101) A61M 16/0069 (20140204) Original (OR) Class A61M 2202/0225 (20130101) A61M 2205/3303 (20130101) A61M 2205/3592 (20130101) A61M 2205/8206 (20130101) A61M 2230/46 (20130101)
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11786713 — Methods and compositions related to physiologically responsive microneedle delivery systems

US 11786713	Gu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
ASSIGNEE(S)	NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
INVENTOR(S)	Zhen Gu (Raleigh, North Carolina); Yanqi Ye (Raleign, North Carolina)
ABSTRACT	Disclosed herein are microneedle devices, kits comprising the microneedle devices, and methods of using the microneedle devices. Specifically, disclosed is a device for transport of a material across a biological barrier of a subject comprising: a plurality of microneedles each having a base end and a tip, with at least one pathway disposed at or between the base end and the tip; a substrate to which the base ends of the microneedles are attached or integrated; and at least one reservoir which is in connection with the base ends of the microneedles array, wherein the reservoir comprises an agent delivery system, wherein the agent delivery system comprises an agent to be transported across the biological barrier, or a means for producing an agent to be transported across the biological barrier, and a means for detecting a physiological signal from the recipient.
FILED	Tuesday, March 30, 2021
APPL NO	17/217199
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) A61K 38/28 (20130101) A61K 38/28 (20130101) A61K 38/44 (20130101) A61K 38/44 (20130101) A61K 38/47 (20130101) A61K 38/47 (20130101) A61K 47/36 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/00 (20130101) A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0023 (20130101) A61M 2037/0053 (20130101) A61M 2202/07 (20130101) A61M 2230/201 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0677 (20130101) Enzymes C12Y 101/03004 (20130101) C12Y 302/01001 (20130101) C12Y 302/01003 (20130101)
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11786730 — Method and system for tuning of movement disorder therapy devices

US 11786730	Heldman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	Great Lakes NeuroTechnologies Inc. (Cleveland, Ohio)
ASSIGNEE(S)	Great Lakes NeuroTechnologies Inc. (Cleveland, Ohio)
INVENTOR(S)	Dustin A. Heldman (Shaker Heights, Ohio); Joseph P. Giuffrida (Hinckley, Ohio); Thomas O. Mera (Columbus, Ohio)
ABSTRACT	A system and method for tuning the parameters of a therapeutic medical device comprises a movement measurement data acquisition system capable of wireless transmission; processing comprising kinematic feature extraction, a scoring algorithm trained using scores from expert clinicians, a therapeutic device parameter setting adjustment suggestion algorithm preferably trained using the parameter setting adjustment judgments of expert clinicians; and a display and/or means of updating the parameter settings of the treatment device. The invention facilitates the treatment of movement disorders including Parkinson's disease, essential tremor and the like by optimizing deep brain stimulation (DBS) parameter settings, eliminating as much as possible motor symptoms and reducing time and costs of surgical and outpatient procedures and improving patient outcomes. In preferred embodiments, the system provides recommendations for treatment which may be semi-automatically or automatically applied to update the parameter settings of a treatment device such as a DBS implant.
FILED	Tuesday, April 27, 2021
APPL NO	17/241529
ART UNIT	3626 — Business Methods - Incentive Programs, Coupons; Operations Research; Electronic Shopping; Health Care; Point of Sale, Inventory, Accounting; Cost/ Price, Reservations, Shipping and Transportation; Business Processing
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36067 (20130101) Original (OR) Class A61N 1/36139 (20130101) A61N 1/37217 (20130101) A61N 1/37247 (20130101)
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11786743 — Scalable stimulation waveform scheduler

US 11786743	Peterson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Naval Information Warfare Center Pacific (NIWCPACIFIC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	Medtronic, Inc. (Minneapolis, Minnesota)
ASSIGNEE(S)	Medtronic, Inc. (Minneapolis, Minnesota)
INVENTOR(S)	Erik J. Peterson (Fridley, Minnesota); Mandla Shongwe (Brooklyn Park, Minnesota)
ABSTRACT	A medical device stores a set of stimulation profiles, wherein each stimulation profile of the set of stimulation profiles is associated with a set of values for stimulation parameters; selects from the set of stimulation profiles, one or more active stimulation profiles; produces, by a stimulation generator, multiple electrical pulses based on the one or more active stimulation profiles; and separately controls parameter values of respective individual pulses of the multiple pulses.
FILED	Monday, August 10, 2020
APPL NO	16/989444
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/3615 (20130101) A61N 1/36062 (20170801) A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 1/36082 (20130101) A61N 1/36107 (20130101) A61N 1/36146 (20130101) A61N 1/36175 (20130101) A61N 1/36178 (20130101) A61N 1/36189 (20130101) A61N 1/37247 (20130101) Original (OR) Class
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11786750 — Modulating neural activity in brainstem circuitry with light

US 11786750	Jenkins et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Biomedical Imaging and Bioengineering (NIBIB) NIH Office of the Director (NIHOD) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); VANDERBILT UNIVERSITY (Nashville, Tennessee)
INVENTOR(S)	Michael W. Jenkins (Cleveland, Ohio); Stephen J. Lewis (Cleveland, Ohio); Hillel J. Chiel (Cleveland, Ohio); Eric Duco Jansen (Cleveland, Ohio); Junqi Zhuo (Cleveland, Ohio); Emilie Lothet (Cleveland, Ohio); Gjinovefa Kola (Cleveland, Ohio)
ABSTRACT	The present disclosure relates to modulating neural activity within brainstem circuitry to evoke a certain bodily function (e.g., cardiorespiratory response) in a patient. A controller can configure a light signal (such as an infrared light signal) to deliver an amount of radiant exposure to a specific portion of the brainstem for a time. The specific portion of the brainstem can include brainstem circuitry that is the control center for the certain bodily function. The configured light signal can be delivered to the specific portion of the brainstem by an optrode for the time. During application, the light signal can deliver the amount of radiant exposure to the specific portion of the brainstem to evoke the certain bodily function.
FILED	Friday, November 30, 2018
APPL NO	16/767277
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/067 (20210801) A61N 5/0601 (20130101) A61N 5/0622 (20130101) Original (OR) Class A61N 2005/0626 (20130101) A61N 2005/0659 (20130101)
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11787764 — Heptamethine cyanines for use as fluorescent markers of the biliary and renal systems

US 11787764	Schnermann et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	CHILDREN'S NATIONAL MEDICAL CENTER (Washington, District of Columbia); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH and HUMAN SERVICES (Bethesda, Maryland)
ASSIGNEE(S)	CHILDREN'S NATIONAL MEDICAL CENTER (Washington, District of Columbia); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH and HUMAN SERVICES (Bethesda, Maryland)
INVENTOR(S)	Martin John Schnermann (Rockville, Maryland); Peter C. W. Kim (Washington, District of Columbia); Jaepyeong Cha (Laurel, Maryland); Roger Rauhauser Nani (Fredrick, Maryland)
ABSTRACT	Heptamethine cyanines for use as fluorescent markers of the biliary and renal systems are disclosed. Certain heptamethine cyanines exhibit renal system specificity, while others exhibit biliary system specificity. The compounds may be used for diagnostic purposes and/or for visualization of renal or biliary systems during surgery.
FILED	Thursday, February 14, 2019
APPL NO	16/970155
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/006 (20130101) A61K 49/0032 (20130101) A61K 49/0058 (20130101) Heterocyclic Compounds C07D 209/10 (20130101) Original (OR) Class C07D 403/12 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/533 (20130101) G01N 33/582 (20130101) G01N 2021/6439 (20130101)
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11787769 — Inhibitors of influenza viral entry

US 11787769	Rong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Chicago Biosolutions, Inc. (Chicago, Illinois); The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois); CHICAGO BIOSOLUTIONS, INC. (Chicago, Illinois)
INVENTOR(S)	Lijun Rong (Westmont, Illinois); Irina Gaisina (Berwyn, Illinois); Gregory R. Thatcher (Tucson, Arizona); Norton Peet (Chicago, Illinois)
ABSTRACT	Vaccination is the most prevalent prophylactic means for controlling seasonal influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Therefore, new therapeutic options are needed for acute treatment of influenza infections to control this virus and prevent epidemic/pandemic situations from developing. Described herein are fast-acting, orally active acylated amino-substituted heterocyclyl compounds effective to control this virus. In one aspect, described herein is a method of treating an influenza infection in a subject comprising administering to the subject the compounds described herein.
FILED	Tuesday, May 03, 2022
APPL NO	17/735235
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Heterocyclic Compounds C07D 215/58 (20130101) Original (OR) Class
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11787794 — Aminothiazole compounds and methods using same

US 11787794	Issa et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Temple University Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania)
INVENTOR(S)	Jean-Pierre J. Issa (Philadelphia, Pennsylvania); Hanghang Zhang (Philadelphia, Pennsylvania); Magid Abou-Gharbia (Exton, Pennsylvania); Wayne E. Childers (New Hope, Pennsylvania); George C. Morton (Collegeville, Pennsylvania)
ABSTRACT	The present invention includes novel aminothiazole compounds of formula (I), which are useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of formula (I)
FILED	Thursday, November 07, 2019
APPL NO	16/676630
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) A61K 31/427 (20130101) A61K 31/706 (20130101) A61K 31/706 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 417/06 (20130101) C07D 417/14 (20130101) Original (OR) Class
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11787795 — Inhibitors of RNA guided nucleases and uses thereof

US 11787795	Choudhary et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Amit Choudhary (Cambridge, Massachusetts); Peng Wu (Boston, Massachusetts); Basudeb Maji (Boston, Massachusetts); Elisa Franco (Oakland, California); Hari K. K. Subramanian (Oakland, California)
ABSTRACT	Compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.
FILED	Tuesday, October 31, 2017
APPL NO	16/346392
ART UNIT	1699 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 255/00 (20130101) C07C 291/00 (20130101) C07C 291/00 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 471/20 (20130101) C07D 487/10 (20130101) C07D 493/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101)
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11787799 — Potent antiviral pyrazolopyridine compounds

US 11787799	Krogstad et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Paul Krogstad (Los Angeles, California); Michael E. Jung (Los Angeles, California); Jun Zuo (Los Angeles, California); Yanpeng Xing (Los Angeles, California)
ABSTRACT	The present technology provides compounds according to Formulas (I), (II), or (III) useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a cell and/or treating subjects suffering from an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus.
FILED	Tuesday, June 08, 2021
APPL NO	17/342182
ART UNIT	1621 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) A61P 31/14 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class
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11787835 — C19 scaffolds and steroids and methods of use and manufacture thereof

US 11787835	Micalizio
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S)	Trustees of Dartmouth College (Hanover, New Hampshire)
INVENTOR(S)	Glenn C. Micalizio (Norwich, Vermont)
ABSTRACT	The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma.
FILED	Thursday, September 05, 2019
APPL NO	17/272091
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Steroids C07J 1/0055 (20130101) C07J 7/002 (20130101) C07J 75/005 (20130101) Original (OR) Class
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11787839 — Targeting α2δ-1-bound glutamate receptors for treating diseases and disorders

US 11787839	Pan
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Hui-lin Pan (Houston, Texas)
ABSTRACT	The present disclosure provides α2δ-1 C-terminal domain mimetics for the treatment of pain, epilepsy or other disorders in a subject. Further provided is an α2δ-1 C-terminal domain peptide which blocks binding of α2δ-1 to the glutamate receptors NMDAR and AMPAR.
FILED	Tuesday, August 14, 2018
APPL NO	16/639076
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/485 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 23/00 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/00 (20130101) Original (OR) Class C07K 14/005 (20130101) C07K 2319/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/1138 (20130101) C12N 2740/15043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5041 (20130101)
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11787845 — Synthetic plasmodium antigens, compositions, and uses thereof

US 11787845	Adams et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	University of South Florida (Tampa, Florida); Washington University (St. Louis, Missouri); Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); WASHINGTON UNIVERSITY (St. Louis, Missouri); CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S)	John H. Adams (Tampa, Florida); Christopher L. King (Moreland Hills, Ohio); Niraj H. Tolia (St. Louis, Missouri); Edwin Chen (St. Louis, Missouri); Nichole Diane Salinas (St. Louis, Missouri); Miriam Thankam George (Nilgris, India); Francis B. Ntumngia (Tampa, Florida); Samantha Jones Barnes (Tampa, Florida)
ABSTRACT	Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof.
FILED	Tuesday, November 24, 2020
APPL NO	17/103275
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) A61K 2039/575 (20130101) A61K 2039/55566 (20130101) Peptides C07K 14/001 (20130101) C07K 14/445 (20130101) Original (OR) Class
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11787846 — EphA2 T-cell epitope agonists and uses therefore

US 11787846	Storkus et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
INVENTOR(S)	Walter J. Storkus (Glenshaw, Pennsylvania); Michael S. Kinch (Laytonsville, Maryland)
ABSTRACT	EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative derivatives thereof. The EphA2 T-cell epitopes are useful in an assay, such as an ELISPOT assay, that may be used to determine and/or quantify a patient's immune responsiveness to EphA2. The epitopes also are useful in methods of modulating a patient's immune reactivity to EphA2, which has substantial utility as a treatment for cancers that overexpress EphA2, such as renal cell carcinoma (RCC). The EphA2 epitopes also can be used to vaccinate a patient against EphA2, by in vivo or ex vivo methods.
FILED	Wednesday, August 19, 2020
APPL NO	16/997197
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1793 (20130101) A61K 39/0011 (20130101) A61K 2039/55566 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/47 (20130101) C07K 14/705 (20130101) C07K 14/4748 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/5091 (20130101) G01N 33/56966 (20130101) G01N 33/56972 (20130101) G01N 2333/57 (20130101) G01N 2333/5409 (20130101)
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11787854 — Immunological targeting of pathological tau proteins

US 11787854	Sigurdsson
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	New York University (New York, New York)
ASSIGNEE(S)	NEW YORK UNIVERSITY (New York, New York)
INVENTOR(S)	Einar M. Sigurdsson (Scarsdale, New York)
ABSTRACT	The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose Alzheimer's Disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject.
FILED	Thursday, November 05, 2020
APPL NO	17/090359
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/0005 (20130101) A61K 39/0007 (20130101) A61K 39/3955 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/20 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2800/2821 (20130101)
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11787858 — Anti-LILRB3 antibodies and methods of use thereof

US 11787858	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Icahn School of Medicine at Mount Sinai (New York, New York)
ASSIGNEE(S)	Icahn School of Medicine at Mount Sinai (New York, New York)
INVENTOR(S)	Shu-Hsia Chen (New York, New York); Ping-Ying Pan (New York, New York)
ABSTRACT	Antibodies and antibody fragments that specifically bind to LILRB3 are disclosed. Also provided herein are compositions comprising antibodies and antibody fragments that specifically bind to LILRB3 and methods of use thereof.
FILED	Friday, December 22, 2017
APPL NO	16/471395
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2317/75 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/12 (20130101)
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11787865 — Bifunctional molecules for lysosomal targeting and related compositions and methods

US 11787865	Bertozzi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Carolyn Bertozzi (Menlo Park, California); Steven Banik (Stanford, California); Kayvon Pedram (Stanford, California); Green Ahn (Stanford, California)
ABSTRACT	Provided are bifunctional molecules that include a first moiety that specifically binds a cell surface molecule or extracellular molecule, and a second moiety that specifically binds a lysosomal targeting molecule. The bifunctional molecules find use, e.g., for targeted degradation of cell surface and extracellular molecules (e.g., proteins) via the endosomal/lysosomal pathway. Also provided are compositions and kits that include the bifunctional molecules, as well as methods of using the bifunctional molecules. Methods of making bifunctional molecules are also provided.
FILED	Tuesday, October 12, 2021
APPL NO	17/499272
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/6425 (20170801) A61K 47/6849 (20170801) A61K 47/6855 (20170801) Peptides C07K 16/2827 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 16/2881 (20130101) C07K 2317/55 (20130101) C07K 2317/77 (20130101)
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11788056 — Induction of protective immunity against antigens

US 11788056	Curtiss, III et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Roy Curtiss, III (Gainesville, Florida); Shifeng Wang (Gainesville, Florida)
ABSTRACT	Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
FILED	Friday, March 26, 2021
APPL NO	17/213619
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/08 (20130101) A61K 39/0275 (20130101) A61K 2039/522 (20130101) A61K 2039/523 (20130101) A61K 2039/542 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/36 (20130101) Original (OR) Class C12N 15/74 (20130101)
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11788063 — Systems and methods for culturing epithelial cells

US 11788063	Bhatia et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Sangeeta Bhatia (Cambridge, Massachusetts); Jing Shan (Cambridge, Massachusetts); Anne Carpenter Van Dyk (Cambridge, Massachusetts); David Logan (Cambridge, Massachusetts); Nathan Ross (Cambridge, Massachusetts)
ABSTRACT	The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the discovery that compositions and methods for primary cells in a high-throughput co-culture platform, image analysis for distinguishing cells in co-cultures and assays that are suitable for screening of agents in epithelial cells, such as hepatocytes.
FILED	Thursday, August 27, 2020
APPL NO	17/004970
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) Original (OR) Class C12N 2502/1323 (20130101) C12N 2531/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101)
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11788064 — Method of increasing proliferation of pancreatic beta cells, treatment method, and composition

US 11788064	Stewart et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York)
ASSIGNEE(S)	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York)
INVENTOR(S)	Andrew F. Stewart (New York, New York); Courtney Ackeifi (New York, New York); Peng Wang (New York, New York); Bob Devita (New York, New York)
ABSTRACT	Disclosed herein are methods of increasing cell proliferation in a population of pancreatic beta cells. Also disclosed are methods of treating a subject for a condition associated with insufficient insulin secretion. Also disclosed is a composition comprising a DYRK1 A inhibitor and a GLP1R agonist. The disclosure further describes a method of regenerating pancreatic beta cells in a transplant patient.
FILED	Saturday, January 05, 2019
APPL NO	16/959390
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 38/22 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 5/48 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0676 (20130101) Original (OR) Class C12N 2501/335 (20130101) C12N 2501/727 (20130101)
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11788080 — Modified cleavases, uses thereof and related kits

US 11788080	Desai et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Encodia, Inc. (San Diego, California)
ASSIGNEE(S)	Encodia, Inc. (San Diego, California)
INVENTOR(S)	Kevin Desai (San Diego, California); Kevin L. Gunderson (San Diego, California); Robert C. James (San Diego, California); Lei Shi (San Diego, California); Stephen Verespy, III (San Diego, California)
ABSTRACT	Provided herein are modified cleavases for removing amino acids from peptides, polypeptides, and proteins. Also provided are methods of using the modified cleavases for treating polypeptides, and kits comprising the modified cleavase. In some embodiments, the methods and the kits also include other components for macromolecule sequencing and/or analysis.
FILED	Monday, June 27, 2022
APPL NO	17/850516
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/06 (20130101)
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11788083 — Type VI CRISPR orthologs and systems

US 11788083	Zhang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Feng Zhang (Cambridge, Massachusetts); Omar O. Abudayyeh (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Eric S. Lander (Cambridge, Massachusetts)
ABSTRACT	The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
FILED	Monday, June 19, 2017
APPL NO	16/310577
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/8213 (20130101) C12N 15/8509 (20130101) C12N 2310/20 (20170501) C12N 2800/22 (20130101)
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11788087 — BCL11A guide delivery

US 11788087	Bauer
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
ASSIGNEE(S)	THE CHILDREN'S MEDICAL CENTER CORPORATION (Cambridge, Massachusetts)
INVENTOR(S)	Daniel Bauer (Cambridge, Massachusetts)
ABSTRACT	Provided herein are 2′-O-methyl 3′phosphorothioate (MS)-modified synthetic nucleic acid molecules (single guide RNAs (sgRNAs)) for the use with a Cas9 nuclease in combination as a ribonucleoprotein (RNP) complex for an electroporation-based ex vivo targeted gene disruption of the BCL11A erythroid enhancer's +55, +58, or +62, functional regions. Additionally, provided herein are said RNP complexes (Cas9:MS-sgRNA), and compositions comprising the modified synthetic nucleic acid molecules or said RNP complexes, and methods for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.
FILED	Friday, May 25, 2018
APPL NO	16/616224
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 35/28 (20130101) A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/85 (20130101) C12N 15/87 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/315 (20130101) C12N 2310/346 (20130101)
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11788088 — CRISPR/Cas system and method for genome editing and modulating transcription

US 11788088	Clarke et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Ryan E. Clarke (Chicago, Illinois); Bradley J. Merrill (Chicago, Illinois); Matthew S. MacDougall (Chicago, Illinois); Hannah M. Pennington (Chicago, Illinois); Brian R. Shy (Chicago, Illinois)
ABSTRACT	A CRISPR/Cas system and method for editing or regulating transcription of a genome of a cell are provided, wherein the system includes a Cas endonuclease fused with one or more degron sequences and at least one activatable cognate single guide RNA harboring an inactivation sequence in a non-essential region of the cognate sgRNA, wherein said inactivation sequence comprises one or more endonuclease recognition sites of, e.g., a ribozyme.
FILED	Friday, September 21, 2018
APPL NO	16/650496
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 2319/06 (20130101) C07K 2319/80 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/121 (20130101) C12N 2310/122 (20130101) C12N 2310/123 (20130101) Enzymes C12Y 603/02019 (20130101)
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11788091 — Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth

US 11788091	Gioeli
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
INVENTOR(S)	Daniel G. Gioeli (Charlottesville, Virginia)
ABSTRACT	Provided herein is a previously unannotated lncRNA lying within exon six and 3′UTR of the LCK gene, labeled “HULLK” for Hormone-Upregulated lncRNA within LCK. HULLK is a novel lncRNA situated within the LCK gene that can serve as an oncogene in PCa. Accordingly, provided are methods and compositions for diagnosing and treating prostate cancer based on HULLK that regulates prostate cancer cell growth.
FILED	Friday, August 21, 2020
APPL NO	16/999959
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101)
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11788101 — Genomic insulator elements and uses thereof

US 11788101	Stamatoyannopoulos et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington)
ASSIGNEE(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington)
INVENTOR(S)	George Stamatoyannopoulos (Seattle, Washington); John Stamatoyannopoulos (Seattle, Washington)
ABSTRACT	Provided herein are methods for identifying high potency genomic insulator elements that can be used in a vector composition e.g., that are useful for preventing unwanted expression of neighboring genes, such as proto-oncogenes, when administered to a subject in need thereof. Also provided herein are methods for treating disease and methods for administering a nucleic acid to a subject using such vectors.
FILED	Friday, January 31, 2020
APPL NO	16/778996
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2740/15043 (20130101) C12N 2740/16043 (20130101) C12N 2830/40 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101)
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11788111 — Compositions and methods for making selenocysteine containing polypeptides

US 11788111	Soll et al.
FUNDED BY	Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	YALE UNIVERSITY (New Haven, Connecticut)
INVENTOR(S)	Dieter Soll (Guilford, Connecticut); Takahito Mukai (New Haven, Connecticut); Kyle Hoffman (New Haven, Connecticut)
ABSTRACT	Non-naturally occurring tRNA^Secand methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring tRNA^Seccan be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the requirement of an SECIS element. In some embodiments, selenocysteine containing polypeptides are manufactured by co-expressing a non-naturally occurring tRNA^Seca recombinant expression system, such as E. coli, with SerRS, EF-Tu, SelA, or PSTK and SepSecS, and an mRNA with at least one codon that recognizes the anticodon of the non-naturally occurring tRNA^Sec.
FILED	Thursday, October 04, 2018
APPL NO	16/754130
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 209/01001 (20130101)
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11788112 — L-2-hydroxyglutarate and stress induced metabolism

US 11788112	Intlekofer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Memorial Sloan-Kettering Cancer Center (New York, New York)
ASSIGNEE(S)	Memorial Sloan-Kettering Cancer Center (New York, New York)
INVENTOR(S)	Andrew M. Intlekofer (New York, New York); Craig B. Thompson (New York, New York)
ABSTRACT	The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
FILED	Tuesday, June 25, 2019
APPL NO	16/452297
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/711 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/32 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 2500/10 (20130101) G01N 2800/7038 (20130101)
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11788113 — Fluorescence-based reporters for mutagenesis detection in E. coli

US 11788113	Camps et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Manel Camps (Santa Cruz, California); Jennifer Allen (Santa Cruz, California)
ABSTRACT	Direct detection of mutagenesis in prokaryotes by reversion of an inactivating mutation (reversion mutation assay), producing a quantitative signal for in vivo mutagenesis, may greatly reduce the amount of test chemicals and labor involved in these assays. Further, transcriptional coupling of β-lactamase reversion and GFP, translational fusion between β-lactamase and GFP with stop codon in GFP, and a novel dual reporter to monitor continuous mutagenesis may be used in methods described herein.
FILED	Monday, April 25, 2022
APPL NO	17/728812
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/86 (20130101) C12N 15/72 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Original (OR) Class Enzymes C12Y 305/02006 (20130101)
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11788120 — RNA printing and sequencing devices, methods, and systems

US 11788120	Sims et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Peter A. Sims (Ardsley, New York); Sayantan Bose (Collegeville, Pennsylvania); Jinzhou Yuan (Edgewater, New Jersey)
ABSTRACT	Described herein are devices, systems, and methods for trapping single-cell lysates in sealed, microwells capable of printing RNA on glass or capturing RNA on beads. These provide efficient, inexpensive manipulation of RNA from individual cells suitable for single-cell transcriptomics on a large scale. Also described are dual barcode capture beads and merged barcode capture beads.
FILED	Tuesday, November 27, 2018
APPL NO	16/766928
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 2300/0829 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6834 (20130101) Original (OR) Class C12Q 1/6869 (20130101)
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11788123 — Systems and methods for high-throughput image-based screening

US 11788123	Zhuang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Xiaowei Zhuang (Lexington, Massachusetts); George Alexander Emanuel (Cambridge, Massachusetts); Jeffrey R. Moffitt (Boston, Massachusetts)
ABSTRACT	The present invention generally relates to imaging cells, for example, to determine phenotypes and/or genotypes in populations of cells. The cells may be exposed to a nucleic acid comprising an identification portion, which may be used to distinguish the cells from each other. In some embodiments, the cells may be exposed to a nucleic acid comprising an expression portion. The identification portion, the expression portion, or both may be introduced into the genome of a host organism or as exogenous materials, e.g. plasmids.
FILED	Friday, May 25, 2018
APPL NO	16/616833
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class C12Q 2525/161 (20130101) C12Q 2563/179 (20130101) C12Q 2565/514 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) C40B 70/00 (20130101)
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11788125 — Molecular fuses for real-time, label-free, multiplexed imaging of RNAs in living cells

US 11788125	Green
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S)	Alexander Green (Scottsdale, Arizona)
ABSTRACT	Provided herein are imaging probes and systems and methods employing such imaging probes for real-time, label-free, multiplexed imaging of RNAs in living cells. More particularly, aptamer-based sensors (“aptasensors”) and molecular fuses comprising multiple aptasensors are genetically encoded imaging probes comprising RNA-target binding sequence and an intramolecular reconfiguration sequence. The probe is configured such that binding of a RNA target by the RNA-target binding sequence triggers the intramolecular reconfiguration sequence to reconfigure such that an optically detectable output is generated by the probe.
FILED	Wednesday, May 19, 2021
APPL NO	17/324944
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 2310/16 (20130101) C12N 2310/531 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class C12Q 2525/205 (20130101) C12Q 2525/301 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101)
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11788135 — Methods for genome characterization

US 11788135	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Yaping Liu (Cambridge, Massachusetts); Manolis Kellis (Cambridge, Massachusetts); Viktor Adalsteinsson (Cambridge, Massachusetts); Zhizhuo Zhang (Cambridge, Massachusetts)
ABSTRACT	As described below, disclosed herein are methods of analyzing DNA methylation in cell-free DNA (cfDNA) and genomic DNA (gDNA) from sequencing data.
FILED	Friday, August 04, 2017
APPL NO	16/323158
ART UNIT	1672 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6827 (20130101) C12Q 1/6827 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2521/331 (20130101) C12Q 2521/507 (20130101) C12Q 2600/154 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 40/00 (20190201) G16B 40/30 (20190201)
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11788147 — Markers of triple-negative breast cancer and uses thereof

US 11788147	Pietenpol et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Jennifer A. Pietenpol (Nashville, Tennessee); Brian Lehmann (Nashville, Tennessee); Josh Bauer (Nashville, Tennessee); Xi Chen (Nashville, Tennessee)
ABSTRACT	In one aspect provided herein are methods of determining a triple negative breast cancer (TNBC) subtype in an individual in need thereof comprising determining expression of one or more genes in one or more TNBC cells of the individual; and comparing the expression of the one or more genes in the TNBC cells with the expression of the one or more genes in a control. In another aspect, the methods are directed to determining a treatment protocol for the TNBC patient based on the TNBC subtype. In another aspect, the methods are directed to predicting whether an individual will benefit from a treatment for a particular TNBC subtype. In yet another aspect, the invention is directed to a method of determining whether an agent can be used to treat a TNBC subtype.
FILED	Friday, January 17, 2020
APPL NO	16/746721
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101)
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11788151 — C-RAF mutants that confer resistance to RAF inhibitors

US 11788151	Emery et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD)
APPLICANT(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S)	Caroline Emery (Kansas City, Missouri); Rajee Antony (Norwood, Massachusetts); Levi A. Garraway (Newton, Massachusetts)
ABSTRACT	Nucleic acids and proteins having a mutant C-RAF sequence, and methods of identifying patients having cancer who are likely to benefit from a combination therapy and methods of treatment are provided.
FILED	Wednesday, August 11, 2021
APPL NO	17/399563
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 207/11001 (20130101)
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11788156 — Compositions comprising riboregulators and methods of use thereof

US 11788156	Green et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Defense Threat Reduction Agency (DTRA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts)
INVENTOR(S)	Alexander A. Green (Chestnut Hill, Massachusetts); Peng Yin (Cambridge, Massachusetts); James J. Collins (Newton, Massachusetts); Jongmin Kim (Cambridge, Massachusetts)
ABSTRACT	The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.
FILED	Thursday, September 16, 2021
APPL NO	17/477456
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1138 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Original (OR) Class
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11788943 — System and method for sperm sorting

US 11788943	Demirci et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S)	THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
INVENTOR(S)	Utkan Demirci (Cambridge, Massachusetts); Waseem Asghar (Boston, Massachusetts)
ABSTRACT	A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
FILED	Monday, July 25, 2022
APPL NO	17/872872
ART UNIT	1799 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/061 (20130101) C12N 5/0612 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4005 (20130101) G01N 15/00 (20130101) G01N 15/10 (20130101) Original (OR) Class G01N 2001/4088 (20130101) G01N 2015/0003 (20130101) G01N 2015/0065 (20130101) G01N 2015/1006 (20130101) G01N 2015/1081 (20130101) G01N 2800/367 (20130101)
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11788947 — System and method for controlling droplet dispensing

US 11788947	Anderson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	INTEGRATED DNA TECHNOLOGIES, INC. (Coralville, Iowa)
ASSIGNEE(S)	INTEGRATED DNA TECHNOLOGIES, INC. (Coralville, Iowa)
INVENTOR(S)	Keith Miller Anderson (Moss Beach, California); Guillermo Alfredo Cornejo (Redwood City, California)
ABSTRACT	Systems and methods for controlling volumes of droplets is provided herein. In some cases, the systems comprise: a plurality of first light sources, a second light source, wherein a first light beam emitted a first light source of said plurality of first light sources is configured to intersect with a second light beam emitted from said second light source at an intersection area, wherein said system is configured to measure a characteristic of said droplet as it passes through said intersection area. Systems and methods for measuring volumes of droplets and for distinguishing between bubbles and droplets are also provided.
FILED	Thursday, January 31, 2019
APPL NO	16/965733
ART UNIT	3754 — Fluid Handling and Dispensing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) Original (OR) Class G01N 35/1016 (20130101) G01N 2015/1481 (20130101)
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11788962 — Method and apparatus for rapid detection of bacterial contamination

US 11788962	Rao et al.
FUNDED BY	Department of Health and Human Services (HHS) Food and Drug Administration (FDA)
APPLICANT(S)	UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland)
ASSIGNEE(S)	UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland)
INVENTOR(S)	Govind Rao (Ellicott City, Maryland); Yordan Kostov (Ellicott City, Maryland); Mustafa Al-Adhami (Silver Spring, Maryland); Chandrasekhar Gurramkonda (Baltimore, Maryland)
ABSTRACT	A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
FILED	Monday, January 25, 2021
APPL NO	17/156915
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 2300/044 (20130101) B01L 2300/0681 (20130101) B01L 2300/0816 (20130101) B01L 2300/0867 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2304/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/272 (20130101) G01N 21/645 (20130101) G01N 21/6408 (20130101) G01N 21/6428 (20130101) Original (OR) Class G01N 2021/0112 (20130101) G01N 2201/0221 (20130101) G01N 2333/195 (20130101)
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11789015 — Manipulation of beads in droplets and methods for manipulating droplets

US 11789015	Pamula et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Advanced Liquid Logic, Inc. (San Diego, California)
ASSIGNEE(S)	ADVANCED LIQUID LOGIC, INC. (San Diego, California)
INVENTOR(S)	Vamsee K. Pamula (Cary, North Carolina); Ramakrishna Sista (Cary, North Carolina); Vijay Srinivasan (Cary, North Carolina); Michael G. Pollack (Durham, North Carolina); Allen E. Eckhardt (Durham, North Carolina)
ABSTRACT	Provided herein are methods of splitting droplets containing magnetically responsive beads in a droplet actuator. A droplet actuator having a plurality of droplet operations electrodes configured to transport the droplet, and a magnetic field present at the droplet operations electrodes, is provided. The magnetically responsive beads in the droplet are immobilized using the magnetic field and the plurality of droplet operations electrodes are used to split the droplet into first and second droplets while the magnetically responsive beads remain substantially immobilized.
FILED	Tuesday, September 01, 2020
APPL NO	16/948074
ART UNIT	1796 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 31/65 (20220101) B01F 33/451 (20220101) B01F 33/3021 (20220101) B01F 33/3031 (20220101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502761 (20130101) B01L 3/502792 (20130101) B01L 7/52 (20130101) B01L 7/525 (20130101) B01L 2200/027 (20130101) B01L 2200/0647 (20130101) B01L 2200/0673 (20130101) B01L 2300/06 (20130101) B01L 2300/089 (20130101) B01L 2300/0654 (20130101) B01L 2300/0816 (20130101) B01L 2300/0861 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2300/1827 (20130101) B01L 2400/043 (20130101) B01L 2400/0406 (20130101) B01L 2400/0415 (20130101) B01L 2400/0421 (20130101) B01L 2400/0424 (20130101) B01L 2400/0427 (20130101) B01L 2400/0436 (20130101) B01L 2400/0442 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/38 (20130101) G01N 33/54326 (20130101) Original (OR) Class G01N 2001/386 (20130101) G01N 2035/1046 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/11 (20150115) Y10T 436/25 (20150115) Y10T 436/2575 (20150115) Y10T 436/25625 (20150115)
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11789019 — Peptide MHCII tetramers to detect endogenous calnexin specific CD4 T cells

US 11789019	Klein et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	Bruce Steven Klein (Madison, Wisconsin); Marcel Wuethrich (Madison, Wisconsin)
ABSTRACT	The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
FILED	Thursday, August 01, 2019
APPL NO	16/529151
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56961 (20130101) G01N 33/56972 (20130101) Original (OR) Class G01N 2333/70539 (20130101)
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11789022 — MEK1 mutation conferring resistance to RAF and MEK inhibitors

US 11789022	Garraway et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S)	Levi A. Garraway (Newton, Massachusetts); Caroline Emery (Kansas City, Missouri); Nikhil Wagle (Brookline, Massachusetts)
ABSTRACT	Nucleic acids and proteins having a mutant MEK sequence, and methods concerning identification of patients having resistance to treatment with anti-cancer agents, specifically inhibitors of RAF or MEK are provided. Methods of treatment and for optimizing treatment for patients having a mutation in a MEK1 sequence are also provided.
FILED	Tuesday, August 25, 2020
APPL NO	17/002116
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) C12N 15/1003 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6809 (20130101) C12Q 1/6827 (20130101) C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 207/12002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5743 (20130101) Original (OR) Class G01N 2333/91205 (20130101) G01N 2500/10 (20130101) G01N 2500/20 (20130101)
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11789027 — Photocleavable mass-tags for multiplexed mass spectrometric imaging of tissues using biomolecular probes

US 11789027	Lim et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	AmberGen, Inc. (Watertown, Massachusetts)
ASSIGNEE(S)	AmberGen, Inc. (Billerica, Massachusetts)
INVENTOR(S)	Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts)
ABSTRACT	The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. The field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout, and also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI.
FILED	Wednesday, August 11, 2021
APPL NO	17/399461
ART UNIT	1622 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 271/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2400/00 (20130101) G01N 2458/15 (20130101)
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11789029 — Temporal traumatic brain injury biomarkers and methods of use thereof

US 11789029	Martinez et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Briana Martinez (Tempe, Arizona); Sarah Stabenfeldt (Tempe, Arizona); Chris Diehnelt (Chandler, Arizona); Nicholas Stephanopoulos (Scottsdale, Arizona); Crystal Willingham (Tempe, Arizona); Amanda Witten (Phoenix, Arizona); Kendall Lundgreen (Gilbert, Arizona)
ABSTRACT	A unique pipeline is employed for biomarker discovery that entailed domain antibody phage display, next generation sequencing analysis, and nanotechnology strategies to generate antibody mimetics are disclosed. Also disclosed are the temporal biomarkers of traumatic brain injury and their methods of use. In some embodiments, the temporal biomarkers are synthetic peptides comprising the HCDR3 sequences identified using the disclosed pipeline. In some aspects, the synthetic peptides have less than 30 amino acid residues and comprise a biotin scaffold that is linked to the HCDR3 sequences.
FILED	Friday, June 19, 2020
APPL NO	17/620088
ART UNIT	1678 — Organic Chemistry
CURRENT CPC	Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/28 (20130101)
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11789030 — Use of a global assay of coagulation and fibrinolysis to aide in thromboembolism

US 11789030	Goldenberg
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
INVENTOR(S)	Neil Goldenberg (St. Petersburg, Florida)
ABSTRACT	The present invention provides methods for identification of subjects with a rise in plasma coagulability post-diagnosis of thrombotic event (and consequent increased risk for recurrent thromboembolism) as well as for identification of subjects without thrombotic event who exhibit a rise in plasma coagulability for which prophylactic anticoagulation may be warranted for TE prevention, and other methods for identification of perioperative subjects who are at heightened risk for perioperative bleeding and/or for requiring blood transfusion, using the CloFAL assay, to aid in clinical decision making regarding anticoagulant and/or adjunctive clinical management designed to mitigate this heightened thromboembolic risk.
FILED	Tuesday, August 10, 2021
APPL NO	17/398695
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/56 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) Original (OR) Class
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11789167 — High resolution depth-encoding PET detector with prismatoid light guide array

US 11789167	Goldan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York)
ASSIGNEE(S)	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York)
INVENTOR(S)	Amirhossein Goldan (Stony Brook, New York); Andrew Labella (New Rochelle, New York); Wei Zhao (East Setauket, New York); Anthony R. Lubinsky (Port Jefferson Station, New York)
ABSTRACT	Provided is a particle detection device and method of fabrication thereof. The particle detection device includes a scintillator array that includes a plurality of scintillator crystals; a plurality of detectors provided on a bottom end of the scintillator array; and a plurality of prismatoids provided on a top end of the scintillator array. Prismatoids of the plurality of prismatoids are configured to redirect particles between top ends of crystals of the scintillator array. Bottom ends of a first group of crystals of the scintillator array are configured to direct particles to a first detector of the plurality of detectors and bottom ends of a second group of crystals of the scintillator array are configured to direct particles to a second detector substantially adjacent to the first detector.
FILED	Monday, April 25, 2022
APPL NO	17/727995
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Nuclear or X-radiation G01T 1/29 (20130101) G01T 1/202 (20130101) Original (OR) Class G01T 1/1641 (20130101) G01T 1/2002 (20130101)
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11790524 — System and method for quantitative volumetric assessment and modeling of tumor lesions

US 11790524	Jhiang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)	Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S)	Sissy M. Jhiang (Columbus, Ohio); Chia-Hsiang Menq (Columbus, Ohio); Peng Cheng (Westerville, Ohio)
ABSTRACT	Disclosed are systems, methods, and computer program products for tumor lesion identification, segmentation, tracking and analysis, wherein a 3D spatial distribution of the tumor lesions in a target organ forms a unique 3D point structure for a patient.
FILED	Wednesday, June 17, 2020
APPL NO	16/903911
ART UNIT	2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/4842 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/30 (20170101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101)
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11790597 — Methods for three-dimensional cardiac imaging

US 11790597	Moghari et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
ASSIGNEE(S)	THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
INVENTOR(S)	Mehdi H. Moghari (Boston, Massachusetts); Andrew J. Powell (Boston, Massachusetts); Tal Geva (Boston, Massachusetts)
ABSTRACT	The invention features a prospective respiratory motion compensation technique for cardiovascular magnetic resonance imaging of the whole-heart of a free-breathing subject.
FILED	Tuesday, September 25, 2018
APPL NO	16/647784
ART UNIT	2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0044 (20130101) A61B 5/055 (20130101) A61B 5/113 (20130101) A61B 5/7289 (20130101) Image Data Processing or Generation, in General G06T 15/08 (20130101) Original (OR) Class G06T 2210/41 (20130101)
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11791020 — Systems and methods for monitoring subjects having chronic gastrointestinal indications

US 11791020	Atreja et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Icahn School of Medicine at Mount Sinai (New York, New York)
ASSIGNEE(S)	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York)
INVENTOR(S)	Ashish Atreja (New York, New York); Jason Rogers (New York, New York); Milan Patel (New York, New York)
ABSTRACT	Systems and methods are provided for monitoring a user having a chronic gastrointestinal indication. A questionnaire regarding a plurality of conditions is provided on a repeating basis. Each such condition at least partly arises from the gastrointestinal indication. Questionnaire questions are each associated with a corresponding condition and provide an affordance that allows the user to select between low and high values in accordance with user association with the condition. Responses are stored in a data store associated with the user. A user requested report comprising a graphical quality of life measure of the user is provided based upon temporal questionnaire answers. Questionnaire information is communicated to a remote device for medical practitioner evaluation and computation of a temporal overall quality of life score based on a plurality of component quality of life scores, each of which is associated with a condition in the plurality of conditions.
FILED	Friday, February 17, 2017
APPL NO	15/999470
ART UNIT	3626 — Business Methods - Incentive Programs, Coupons; Operations Research; Electronic Shopping; Health Care; Point of Sale, Inventory, Accounting; Cost/ Price, Reservations, Shipping and Transportation; Business Processing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/411 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/1118 (20130101) A61B 5/4238 (20130101) A61B 5/4255 (20130101) A61B 5/4824 (20130101) Electric Digital Data Processing G06F 3/0482 (20130101) G06F 3/04847 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 7/06 (20130101) G08B 21/182 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) Original (OR) Class G16H 15/00 (20180101) G16H 20/10 (20180101) G16H 20/70 (20180101) G16H 40/20 (20180101) G16H 40/67 (20180101) G16H 50/50 (20180101)
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11792381 — Phase-sensitive compressed ultrafast photography systems and methods

US 11792381	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Lihong Wang (Arcadia, California); Taewoo Kim (Alhambra, California); Jinyang Liang (Varennes, Canada); Liren Zhu (Sunnyvale, California)
ABSTRACT	Disclosed herein are systems and methods of phase-sensitive compressed ultrafast photography (pCUP). In some embodiments, a pCUP system comprises: a dark-field imaging system, and a compressed ultrafast photography (CUP system). The dark-field imaging system may comprise a laser source configured to illuminate the subject with a laser pulse; and a beam block configured to pass laser light scattered by the subject as a first series of phase images and block laser light not scattered by the subject. The CUP system may comprise: a spatial encoding module configured to receive the first series of phase images and to produce a second series of spatially encoded phase images; and a streak camera configured to receive the second series of spatially encoded phase images, to deflect each spatially encoded phase image by a temporal deflection distance, and to integrate the deflected phase images into a single raw CUP image.
FILED	Monday, March 02, 2020
APPL NO	16/806691
ART UNIT	2872 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 9/00 (20130101) G01J 2011/005 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4814 (20130101) G01S 7/4865 (20130101) G01S 17/894 (20200101) Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 21/10 (20130101) Pictorial Communication, e.g Television H04N 13/25 (20180501) H04N 13/161 (20180501) Original (OR) Class H04N 13/254 (20180501) H04N 13/282 (20180501) H04N 23/72 (20230101)
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Department of Defense (DOD)

11786124 — Implants using ultrasonic backscatter for radiation detection and oncology

US 11786124	Maharbiz et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Michel M. Maharbiz (El Cerrito, California); Jose M. Carmena (Berkeley, California); Mekhail Anwar (San Francisco, California); Kristofer S. J. Pister (Oakland, California); Stefanie V. Garcia (Oakland, California)
ABSTRACT	Described herein is an implantable device comprising a radiation-sensitive element (such as a transistor) configured to modulate a current as a function of radiation exposure to the transistor; and an ultrasonic device comprising an ultrasonic transducer configured to emit an ultrasonic backscatter that encodes the radiation exposure to the transistor. Further described herein is an implantable device comprising a radiation-sensitive element (such as a diode) configured to generate an electrical signal upon encountering radiation; an integrated circuit configured to receive the electrical signal and modulate a current based on the received electrical signal; and an ultrasonic transducer configured to emit an ultrasonic backscatter based on the modulated current encoding information relating to the encountered radiation. Further described are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also describe are computer systems for operating implantable devices, methods of detecting radiation, methods of treating a solid cancer in a subject, and methods of monitoring a subject for recurrence of a solid cancer.
FILED	Friday, July 07, 2017
APPL NO	16/313858
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0031 (20130101) Original (OR) Class A61B 5/076 (20130101) A61B 5/279 (20210101) A61B 5/686 (20130101) A61B 6/4258 (20130101) A61B 8/48 (20130101) A61B 8/085 (20130101) A61B 8/0808 (20130101) A61B 8/0875 (20130101) A61B 2505/05 (20130101) A61B 2560/0219 (20130101) A61B 2562/12 (20130101) A61B 2562/028 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 39/0208 (20130101) A61M 2205/04 (20130101) A61M 2205/825 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/372 (20130101) A61N 1/0534 (20130101) A61N 1/3605 (20130101) A61N 1/3787 (20130101) A61N 1/37205 (20130101) A61N 5/1071 (20130101) A61N 2005/1087 (20130101) A61N 2007/0021 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101)
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11786170 — Nanomaterial epidermal sensors

US 11786170	Lu et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF)
APPLICANT(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Nanshu Lu (Austin, Texas); Deji Akinwande (Austin, Texas); Shideh Kabiri Ameri Abootorabi (Austin, Texas)
ABSTRACT	Nanomaterial epidermal sensors can be adhered to the skin and worn comfortably and inconspicuously for days to allow for repeated biometric sensing. The nanomaterial epidermal sensors may be comprised of a monolayer of graphene coating a flexible polymer substrate. Various nanomaterial epidermal sensors may be quickly fabricated using a cost-efficient “cut-and-paste” method on transfer paper and can be adhered directly to skin without tape or adhesive, much like a temporary-tattoo. The nanomaterial epidermal sensors may be optically transparent and may be used to measure an electrocardiogram (ECG), an electroencephalogram (EEG) or an electromyogram (EMG) with a signal-to-noise ratio that is comparable to conventional electrodes. In addition, the nanomaterial epidermal sensors may be used to measure other parameters, such as skin temperature or skin hydration.
FILED	Friday, April 28, 2017
APPL NO	16/608994
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/28 (20210101) A61B 5/257 (20210101) A61B 5/291 (20210101) A61B 5/296 (20210101) A61B 5/443 (20130101) Original (OR) Class A61B 5/68335 (20170801) A61B 2562/125 (20130101) A61B 2562/164 (20130101) A61B 2562/222 (20130101) A61B 2562/0285 (20130101)
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11786511 — Methods for increasing circulating mesenchymal stem cells

US 11786511	Gaffney et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Minority Health and Health Disparities (NIMHD)
APPLICANT(S)	Kevin J. Gaffney (Los Angeles, California); Kathleen E. Rodgers (Los Angeles, California); Maira Soto (Los Angeles, California); Michael Weinberg (Los Angeles, California)
ASSIGNEE(S)	University of Southern California (Los Angeles, California)
INVENTOR(S)	Kevin J. Gaffney (Los Angeles, California); Kathleen E. Rodgers (Los Angeles, California); Maira Soto (Los Angeles, California); Michael Weinberg (Los Angeles, California)
ABSTRACT	Disclosed herein are methods for increasing circulating mesenchymal stem cells by administering a compound having the general formula 1 as defined herein, or a pharmaceutically acceptable salt thereof.
FILED	Thursday, August 09, 2018
APPL NO	16/638000
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101)
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11786547 — Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds

US 11786547	Baker et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	SYNEDGEN, INC. (Claremont, California)
ASSIGNEE(S)	SYNEDGEN, INC. (Claremont, California)
INVENTOR(S)	Shenda M. Baker (Upland, California); William P. Wiesmann (Chevy Chase, Maryland); Stacy Marie Townsend (Rancho Cucamonga, California)
ABSTRACT	Described herein are methods of disrupting (e.g., reducing the viscosity of, or dissolving) a preformed biofilm in a subject, the method comprising: administering to the subject an effective amount of a composition comprising a soluble chitosan or derivatized chitosan wherein the soluble chitosan or derivatized chitosan when administered contacts the preformed biofilm, thereby disrupting (e.g., reducing the viscosity of, or dissolving) the preformed biofilm.
FILED	Monday, September 16, 2019
APPL NO	16/572053
ART UNIT	1699 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0043 (20130101) A61K 9/0053 (20130101) A61K 31/722 (20130101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 50/30 (20180101)
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11786582 — Human application of engineered chimeric antigen receptor (CAR) T-cells

US 11786582	Cooper et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Breast Cancer Research Program (USAMRMCBCRP)
APPLICANT(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Laurence J N Cooper (Houston, Texas); Hiroki Torikai (Houston, Texas); Ling Zhang (Houston, Texas); Helen Huls (Houston, Texas); Feng Wang-Johanning (Bastrop, Texas); Lenka Hurton (Houston, Texas); Simon Olivares (Houston, Texas); Janani Krishnamurthy (Houston, Texas)
ABSTRACT	The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.
FILED	Tuesday, April 06, 2021
APPL NO	17/223597
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/00117 (20180801) A61K 39/00119 (20180801) A61K 39/001104 (20180801) A61K 39/001106 (20180801) A61K 39/001109 (20180801) A61K 39/001112 (20180801) A61K 39/001113 (20180801) A61K 39/001119 (20180801) A61K 39/001124 (20180801) A61K 39/001129 (20180801) A61K 39/001151 (20180801) A61K 39/001164 (20180801) A61K 39/001168 (20180801) A61K 39/001171 (20180801) A61K 39/001174 (20180801) A61K 39/001181 (20180801) A61K 39/001182 (20180801) A61K 39/001194 (20180801) A61K 2039/505 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) Peptides C07K 14/5443 (20130101) C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 16/30 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101)
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11786601 — Pegylated capsule-degrading enzyme for the treatment of anthrax

US 11786601	Legler et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Patricia M. Legler (Derwood, Maryland); Arthur M. Friedlander (Frederick, Maryland); Jaimee R. Compton (Washington, District of Columbia)
ABSTRACT	A pegylated, circularly permuted construct of the CapD enzyme (a gamma glutamyl transferase enzyme acting as a hydrolase specific to poly-γ-D-glutamic acid) is used to treat anthrax and other bacterial infections, including but not limited to infection with strains that are resistant to available antibiotics.
FILED	Tuesday, January 18, 2022
APPL NO	17/577893
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) A61K 47/60 (20170801) Original (OR) Class
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11786642 — In situ forming hemostatic form implants

US 11786642	Sharma et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Arsenal Medical Inc. (Watertown, Massachusetts)
ASSIGNEE(S)	Arsenal Medical, Inc. (Watertown, Massachusetts)
INVENTOR(S)	Upma Sharma (Somerville, Massachusetts); Irina Gitlin (San Francisco, California); Gregory T. Zugates (Chelmsford, Massachusetts); Adam Rago (Falmouth, Massachusetts); Parisa Zamiri (Brookline, Massachusetts); Rany Busold (Medford, Massachusetts); Toby Freyman (Waltham, Massachusetts); Robert J. Caulkins (Watertown, Massachusetts); Quynh P. Pham (Methuen, Massachusetts); Changcheng You (Burlington, Massachusetts); Jeffrey D. Carbeck (Belmont, Massachusetts)
ABSTRACT	Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
FILED	Friday, August 07, 2020
APPL NO	16/987754
ART UNIT	3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/12031 (20130101) A61B 17/12163 (20130101) A61B 17/12186 (20130101) A61B 2017/12004 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/2093 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/18 (20130101) A61L 27/18 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 31/06 (20130101) Original (OR) Class A61L 31/06 (20130101) A61L 31/141 (20130101) A61L 31/146 (20130101) A61L 31/148 (20130101) A61L 2400/04 (20130101) A61L 2400/06 (20130101) A61L 2400/18 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/00 (20130101) Compositions of Macromolecular Compounds C08L 63/00 (20130101) C08L 63/00 (20130101) C08L 67/04 (20130101) C08L 67/04 (20130101)
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11786743 — Scalable stimulation waveform scheduler

US 11786743	Peterson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Naval Information Warfare Center Pacific (NIWCPACIFIC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	Medtronic, Inc. (Minneapolis, Minnesota)
ASSIGNEE(S)	Medtronic, Inc. (Minneapolis, Minnesota)
INVENTOR(S)	Erik J. Peterson (Fridley, Minnesota); Mandla Shongwe (Brooklyn Park, Minnesota)
ABSTRACT	A medical device stores a set of stimulation profiles, wherein each stimulation profile of the set of stimulation profiles is associated with a set of values for stimulation parameters; selects from the set of stimulation profiles, one or more active stimulation profiles; produces, by a stimulation generator, multiple electrical pulses based on the one or more active stimulation profiles; and separately controls parameter values of respective individual pulses of the multiple pulses.
FILED	Monday, August 10, 2020
APPL NO	16/989444
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/3615 (20130101) A61N 1/36062 (20170801) A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 1/36082 (20130101) A61N 1/36107 (20130101) A61N 1/36146 (20130101) A61N 1/36175 (20130101) A61N 1/36178 (20130101) A61N 1/36189 (20130101) A61N 1/37247 (20130101) Original (OR) Class
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11786846 — Devices and methods for the integrated filtration, drying, and mechanical processing of active pharmaceutical ingredients

US 11786846	Brancazio et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	David Brancazio (Cambridge, Massachusetts); Allan S. Myerson (Cambridge, Massachusetts); Mohammad A. Azad (Greensboro, North Carolina); Gregory J. Hammersmith (Windsor, Connecticut); Gerard Capellades Mendez (Cambridge, Massachusetts); Clemence Neurohr (Cambridge, Massachusetts); Kersten Rapp (Medway, Massachusetts); Naomi Elizabeth Barbara Briggs (Rockville, Maryland)
ABSTRACT	Devices and methods for filtering, drying, and mechanically processing active pharmaceutical ingredients are generally described.
FILED	Monday, July 20, 2020
APPL NO	16/933158
ART UNIT	1776 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 3/10 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Separation B01D 29/05 (20130101) B01D 29/075 (20210801) B01D 29/86 (20130101) Original (OR) Class B01D 29/608 (20130101) B01D 35/18 (20130101) B01D 2201/204 (20130101)
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11786859 — Air separation sorbent and vacuum assisted pressure swing adsorption process using the same

US 11786859	Alptekin et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) United States Marine Corps (USMC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	TDA Research, Inc (Wheat Ridge, Colorado)
ASSIGNEE(S)	TDA Research, Inc. (Wheat Ridge, Colorado)
INVENTOR(S)	Gökhan O. Alptekin (Boulder, Colorado); Douwe Bruinsma (Louisville, Colorado); Ambalavanan Jayaraman (Highlands Ranch, Colorado); Brandon Gushlaw (Boulder, Colorado)
ABSTRACT	A vacuum assisted pressure swing adsorption device for purifying oxygen from air, comprising: a first adsorption bed of LiLSX adsorbent and second adsorption bed of AgLiLSX adsorbent, wherein the first adsorption bed and the second adsorption bed are connected to each other in series. A method for producing medical oxygen using a vacuum assisted pressure swing adsorption device comprising: a first adsorption bed of LiLSX adsorbent and second adsorption bed of AgLiLSX adsorbent, wherein the first adsorption bed and the second adsorption bed are connected to each other in series.
FILED	Thursday, February 04, 2021
APPL NO	17/168147
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Separation B01D 53/0407 (20130101) B01D 53/0476 (20130101) Original (OR) Class B01D 2253/304 (20130101) B01D 2256/12 (20130101) B01D 2257/104 (20130101) B01D 2259/402 (20130101) B01D 2259/4533 (20130101)
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11786906 — Resistive heaters and anisotropic thermal transfer

US 11786906	Jones et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND) Joint Project Manager Medical Countermeasure Systems (JPM-MCS)
APPLICANT(S)	BIOFIRE DEFENSE, LLC (Salt Lake City, Utah)
ASSIGNEE(S)	Biofire Defense, LLC (Salt Lake City, Utah)
INVENTOR(S)	David E. Jones (Layton, Utah); Michael Bills (Salt Lake City, Utah); Aaron D. Wernerehl (Salt Lake City, Utah); Anson Cole Chamberlain (American Fork, Utah)
ABSTRACT	System, heaters, and heat transfer devices are disclosed. For example, a system for performing polymerase chain reaction includes a support member configured to receive a sample vessel and a heater that is positioned to affect a temperature of the sample vessel. The system additionally includes a heat transfer device disposed between the heater and the sample vessel. The heat transfer device illustratively includes anisotropic fibers axially aligned parallel to one another and positioned to conduct heat from the at least one heater toward the sample vessel in the axial direction of the anisotropic fibers. An exemplary heater includes a body defining one or more channels, a heating element positioned in the one or more channels, and retention members adjacent the one or more channels. At least a portion of the heating element is mechanically interlocked with the channel by deforming the retention members into a closed position.
FILED	Friday, April 14, 2017
APPL NO	16/093124
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 7/52 (20130101) Original (OR) Class B01L 2200/16 (20130101) B01L 2300/1822 (20130101) B01L 2300/1827 (20130101)
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11786926 — Portable and repositionable deposition material applicator enclosure and application system for applying deposition material on a substrate employing non-adherent deposition material waste removal and selective enclosure coupling and decoupling structures or systems employing a plurality of selective coupling forces

US 11786926	Albrecht
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Surface Warfare Center (NSWC)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Crane, Indiana)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	John William Albrecht (Silverdale, Washington)
ABSTRACT	Apparatuses and methods related to improving environmental protection and waste collection from application of deposition material using portable systems that are easier for operators to use on surfaces such as ship hulls are provided. Embodiments include a portable and repositionable deposition material applicator enclosure and application system for applying deposition material on a substrate employing non-adherent deposition material waste removal and selective enclosure coupling and decoupling structures or systems employing magnetic and suction or differential pressure based forces.
FILED	Monday, November 15, 2021
APPL NO	17/526106
ART UNIT	1717 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Spraying Apparatus; Atomising Apparatus; Nozzles B05B 14/30 (20180201) Original (OR) Class Apparatus for Applying Fluent Materials to Surfaces, in General B05C 11/1039 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/06 (20130101) B05D 1/12 (20130101) B05D 2401/32 (20130101) Abrasive or Related Blasting With Particulate Material B24C 3/065 (20130101)
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11787109 — 3-d structures having high temperature stability and improved microporosity

US 11787109	Liu et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Hsiang H. Liu (Santa Clara, California); James O. Hardin, IV (Enon, Ohio); John D. Berrigan (Xenia, Ohio)
ABSTRACT	The present invention relates to 3-D structures having high temperature stability and improved micro-porosity as well as processes of making and using same. The disclosed 3-D are advantageous because they have low densities and low permittivities. When compared to previous 3-D structures, the present structures maintain their low permittivities over a broader range of electromagnetic frequencies. Thus, when used in communication devices such as array antennas, can provided higher communication performance in high temperature environments.
FILED	Thursday, February 16, 2023
APPL NO	18/110505
ART UNIT	1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Original (OR) Class B29C 64/209 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2063/00 (20130101) B29K 2079/08 (20130101) B29K 2081/06 (20130101) B29K 2083/00 (20130101) B29K 2995/0017 (20130101) B29K 2995/0077 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) B33Y 80/00 (20141201)
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11787533 — Rotor assemblies for rotorcraft

US 11787533	Kennedy et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Aviation Applied Technology Directorate (AATD)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Arlington, Virginia)
INVENTOR(S)	Dennis K. Kennedy (Mesa, Arizona); Joshua Jeffrey Bracken (Gilbert, Arizona); Jeffrey L. Sorensen (Fountain Hills, Arizona)
ABSTRACT	A rotor assembly comprises a rotor hub and rotor-blade assemblies. The rotor hub comprises rotor-blade supports. Each rotor-blade assembly is coupled to a respective one of the rotor-blade supports and comprises a flap axle, a hub connector, a rotor blade, and a torsion strap. The flap axle extends through a respective one of the rotor-blade supports and has a central flap-axle axis. The hub connector is pivotable relative to a rotor-blade support about the central flap-axle axis and defines a central hub-connector axis. The rotor blade is coupled to and is pivotable relative to the hub connector, and, together with the hub connector, is pivotable relative to a respective one of the rotor-blade supports about the central flap-axle axis. The torsion strap has a first end, coupled to the rotor blade, and a second end, through which the flap axle passes.
FILED	Thursday, May 20, 2021
APPL NO	17/326222
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 27/35 (20130101) B64C 27/39 (20130101) Original (OR) Class B64C 27/48 (20130101)
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11787570 — Multi-part Marman band clamp with retainer

US 11787570	Reed, Jr. et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Sea Systems Command (NAVSEA)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Billy B. Reed, Jr. (Tucson, Arizona); Mark J. Kocan (Tucson, Arizona)
ABSTRACT	A Marman band clamp has multiple parts, such as two halves, that together make up a ring. The halves are joined by diametrically opposed mechanical connections, one of which is a mechanical release separably mechanically coupled ends of the parts (halves). The mechanical release may include an explosive bolt that is used to release the ends of the halves. The mechanical release may capture portions of the release at the ends of the ring halves after severing of the explosive bolt. A nut may be retained by an end of one of the halves by use of a retainer fastener, such as a pin, to prevent the nut from separating from the ring half end when the bolt is severed. This helps retain the pressurized gases between the severed part of the bolt longer, better using the energy from the pressurized gases to reliably separate the ends of the halves.
FILED	Thursday, August 06, 2020
APPL NO	16/986351
ART UNIT	3678 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/641 (20130101) Original (OR) Class B64G 1/645 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 2/065 (20130101)
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11788156 — Compositions comprising riboregulators and methods of use thereof

US 11788156	Green et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Defense Threat Reduction Agency (DTRA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts)
INVENTOR(S)	Alexander A. Green (Chestnut Hill, Massachusetts); Peng Yin (Cambridge, Massachusetts); James J. Collins (Newton, Massachusetts); Jongmin Kim (Cambridge, Massachusetts)
ABSTRACT	The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.
FILED	Thursday, September 16, 2021
APPL NO	17/477456
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1138 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Original (OR) Class
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11788202 — Optimized thick heteroepitaxial growth of semiconductors with in-situ substrate pretreatment

US 11788202	Tassev
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Vladimir Tassev (Beavercreek, Ohio)
ABSTRACT	A method of performing HVPE heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and ternary-forming gasses (V/VI group precursor), to form a heteroepitaxial growth of a binary, ternary, and/or quaternary compound on the substrate; wherein the carrier gas is Hz, wherein the first precursor gas is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the ternary-forming gasses comprise at least two or more of AsH₃(arsine), PH₃(phosphine), H₂Se (hydrogen selenide), HzTe (hydrogen telluride), SbH₃(hydrogen antimonide, or antimony tri-hydride, or stibine), H₂S (hydrogen sulfide), NH₃(ammonia), and HF (hydrogen fluoride); flowing the carrier gas over the Group II/III element; exposing the substrate to the ternary-forming gasses in a predetermined ratio of first ternary-forming gas to second ternary-forming gas (1tf:2tf ratio); and changing the 1tf:2tf ratio over time.
FILED	Monday, October 17, 2022
APPL NO	18/046943
ART UNIT	1714 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/02 (20130101) C30B 25/04 (20130101) Original (OR) Class C30B 25/18 (20130101) C30B 29/42 (20130101) C30B 29/44 (20130101) C30B 29/48 (20130101) C30B 29/403 (20130101) C30B 29/406 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3556 (20130101) G02F 1/3558 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/024 (20130101) H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02293 (20130101) H01L 21/02387 (20130101) H01L 21/02389 (20130101) H01L 21/02392 (20130101) H01L 21/02395 (20130101) H01L 21/02398 (20130101) H01L 21/02458 (20130101) H01L 21/02461 (20130101) H01L 21/02463 (20130101) H01L 21/02466 (20130101) H01L 21/02505 (20130101) H01L 21/02538 (20130101) H01L 21/02543 (20130101) H01L 21/02546 (20130101) H01L 21/02549 (20130101) H01L 21/02551 (20130101) H01L 21/02568 (20130101) H01L 21/02658 (20130101) H01L 31/1828 (20130101)
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11788429 — Variable tandem fan outlet guide vanes

US 11788429	Hall et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Rolls-Royce Corporation (Indianapolis, Indiana)
ASSIGNEE(S)	Rolls-Royce Corporation (Indianapolis, Indiana)
INVENTOR(S)	Christopher D. Hall (Danville, Indiana); William B. Bryan (Indianapolis, Indiana); Daniel E. Molnar, Jr. (Lebanon, Indiana)
ABSTRACT	A fan assembly includes a fan duct, an inlet fan, and an outlet guide vane assembly. The inlet fan includes blades adapted to force fan exit air toward an aft end of the fan duct. The outlet guide vane assembly is located in the fan duct downstream of the inlet fan and is configured to adjust a direction of the fan exit air received from the blades. The outlet guide vane assembly includes a first plurality of vanes configured to rotate to redirect the fan exit air in a first direction, and a second plurality of vanes located downstream of the first plurality of vanes. The second plurality of vanes are configured to rotate to redirect the fan exit air flowing in the first direction in a second direction to minimize losses created by distortions in fan inlet air and created by the first vanes.
FILED	Wednesday, August 25, 2021
APPL NO	17/412226
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 17/02 (20130101) F01D 17/06 (20130101) F01D 17/162 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/12 (20130101) F05D 2270/102 (20130101) F05D 2270/304 (20130101)
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11788491 — Systems and methods for attachment of materials having different thermal expansion coefficients

US 11788491	Direnzi et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Nicholas Direnzi (Cincinnati, Ohio); John Philip McKay (Boca Raton, Florida); Apostolos Karafillis (Winchester, Massachusetts); David L. Dawson (North Bend, Ohio); Rosa Nemec (Cincinnati, Ohio)
ABSTRACT	Systems and methods for attaching a protective liner to a an aircraft engine component having a different coefficient of thermal expansion in comparison to the protective liner include a mounting member configured to be mounted to the aircraft engine component and an attachment member configured to be attached to the protective liner. The mounting member and the attachment member are coupled to each other such that a portion of the mounting member is received within a portion of the attachment member and such that the mounting member is permitted to move with both radial and rotational freedom relative to the attachment member.
FILED	Wednesday, July 13, 2022
APPL NO	17/863993
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Jet-propulsion Plants F02K 1/80 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2260/31 (20130101) F05D 2300/6033 (20130101)
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11788493 — Mixed-compression inlet duct for turbine engines facilitating supersonic flight

US 11788493	Sinha et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Warfare Center (NAWC)
APPLICANT(S)	Combustion Research and Flow Technology, Inc. (Pipersville, Pennsylvania)
ASSIGNEE(S)	Combustion Research and Flow Technology, Inc. (Pipersville, Pennsylvania)
INVENTOR(S)	Neeraj Sinha (Ivyland, Pennsylvania); Stephen M. Barr (Hellertown, Pennsylvania); Michael R. O'Gara (Sellersville, Pennsylvania)
ABSTRACT	An inlet duct for use with an engine is presented. The invention includes a duct structure, at least one spike disposed along an interior surface of the duct structure, and an inlet throat formed by one or more apexes disposed along an equal number of spikes. The inlet throat corresponds to the minimum cross-sectional area through which airflow passes as otherwise allowed by the maximal obstruction formed by the apex(es) within the duct structure. Each spike is bounded by a longitudinal ridge and a lateral ridge along an upper end and a base along a lower end. The longitudinal ridge and the lateral ridge intersect at the apex. In preferred embodiments, the longitudinal ridge is at least partially non-linear so as to properly conform to the interior surface of the duct structure. The portion of each spike upstream of the inlet throat functions primarily as a supersonic diffuser. The portion of each spike downstream of the inlet throat functions primarily as a subsonic diffuser. Airflow is isentropically compressed and then expanded within the inlet duct so that greater-than-subsonic flow at an input end is reduced to subsonic flow at an output end.
FILED	Friday, July 08, 2022
APPL NO	17/860157
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/02 (20130101) B64D 2033/026 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/04 (20130101) Jet-propulsion Plants F02K 7/10 (20130101) Original (OR) Class
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11788576 — Quick-disconnect ball and socket joint

US 11788576	Brown
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Information Warfare Center (NIWC) Naval Information Warfare Center Pacific (NIWCPACIFIC)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Michael H. Brown (San Diego, California)
ABSTRACT	A quick-disconnect ball and socket joint includes a substantially spherical strain relief node configured to be coupled to an object, such as a cable. The system further comprises an end cap configured to capture the substantially spherical strain relief node, the end cap having a diameter that permits the substantially spherical strain relief node to pass therethrough when the system is in an open position. The system still further comprises a retaining element configured to retain the substantially spherical strain relief node in the end cap. The retaining element is attached to the end cap when the system is in a closed position and the object is prevented from being removed from capture by the end cap. However, in the open position, the retaining element may be removed from capture by the end cap by passing the substantially spherical strain relief node through a diameter of the end cap.
FILED	Wednesday, January 08, 2020
APPL NO	16/737763
ART UNIT	3678 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 27/003 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 21/183 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 11/069 (20130101) Original (OR) Class Belts, Cables, or Ropes, Predominantly Used for Driving Purposes; Chains; Fittings Predominantly Used Therefor F16G 11/03 (20130101) F16G 11/108 (20130101)
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11788646 — Three-way piezoelectrically-actuated microvalve device and method of fabrication

US 11788646	Huff
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Research Laboratory (AFRL)
APPLICANT(S)	CORPORATION FOR NATIONAL RESEARCH INITIATIVES (Reston, Virginia)
ASSIGNEE(S)	Corporation for National Research Initiatives (Reston, Virginia)
INVENTOR(S)	Michael Huff (Oakton, Virginia)
ABSTRACT	A three-way (3-way) Micro-Electro-Mechanical Systems (MEMS)-based micro-valve device and method of fabrication for the implementation of a three-way MEMS-based micro-valve which uses a single piezoelectric actuator. The present invention has a wide range of applications including medical, industrial control, aerospace, automotive, consumer electronics and products, as well as any application(s) requiring the use of three-way micro-valves for the control of fluids. The present invention allows for the implementation of a three-way microvalve device and method of fabrication that can be tailored to the requirements of a wide range of applications and fluid types. The microvalve may employ a novel pressure-balancing scheme wherein the fluid pressure balances the actuator mechanism so that only a small amount of actuation pressure (or force) is needed to switch the state of the actuator and device from open to closed, or closed to open.
FILED	Friday, April 08, 2022
APPL NO	17/716811
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0015 (20130101) Original (OR) Class F16K 99/0028 (20130101) F16K 99/0048 (20130101) F16K 2099/008 (20130101) F16K 2099/0073 (20130101) F16K 2099/0078 (20130101)
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11788725 — Trapped vortex combustor for a gas turbine engine with a driver airflow channel

US 11788725	Duncan et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Systems Command (NAVAIR)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
INVENTOR(S)	Beverly Stephenson Duncan (West Chester, Ohio); Steven Joseph Lohmueller (Reading, Ohio); Eric John Stevens (Mason, Ohio)
ABSTRACT	A trapped vortex combustor for use in a gas turbine engine includes an outer vortex chamber wall and a dome attached to, or formed integrally with, the outer vortex chamber wall. The dome, the outer vortex chamber wall, or both define at least in part an outer trapped vortex chamber and a channel. The channel extends along the circumferential direction at a forward end of the outer vortex chamber wall, the channel configured to receive an airflow through or around the outer vortex chamber wall, the dome, or both and provide such airflow as a continuous annular airflow to the inner surface of the outer vortex chamber wall. The dome further defines a fuel nozzle opening, with all openings in the dome outward of the fuel nozzle opening along the radial direction, excepting any effusion cooling holes having a diameter less than about 0.035 inches, being in airflow communication with the channel.
FILED	Monday, December 06, 2021
APPL NO	17/542900
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/06 (20130101) Original (OR) Class F23R 3/10 (20130101) F23R 3/12 (20130101) F23R 3/30 (20130101) F23R 3/50 (20130101) F23R 3/58 (20130101) F23R 3/60 (20130101) F23R 3/286 (20130101) F23R 2900/00015 (20130101) F23R 2900/03041 (20130101)
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11788797 — Heat transfer device for high heat flux applications and related methods thereof

US 11788797	Haj-Hariri et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA)
APPLICANT(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
INVENTOR(S)	Hossein Haj-Hariri (Charlottesville, Virginia); Reza Monazami (Cambridge, Massachusetts)
ABSTRACT	A device and related method that provides, but is not limited thereto, a two-phase heat transfer device with unique combination of enhanced evaporation and increased cooling capacity. An advantage associated with the device and method includes, but is not limited thereto, increased cooling capacity per unit area, controlled and optimized evaporation, 10 prevention of boiling, and prevention of drying of the evaporator. An aspect associated with an approach may include, but is not limited thereto, using a non-wetting coating or structure to keep working fluid away from the spaces between elongated members of an evaporator and using a wetting coating or structure to form thin films of working fluid around the distal region of the elongated members.
FILED	Thursday, July 18, 2013
APPL NO	14/415423
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/50 (20130101) B64G 1/58 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/187 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2210/14 (20130101) F05D 2260/207 (20130101) F05D 2260/213 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 21/02 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/02 (20130101) F28D 15/04 (20130101) Original (OR) Class F28D 15/046 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/187 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101) H01L 2924/00 (20130101) H01L 2924/0002 (20130101) H01L 2924/0002 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/60 (20130101)
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11788887 — Tunable notch filter

US 11788887	Mann
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) United States Marine Corps (USMC) Marine Corps Systems Command (MARCORSYSCOM)
APPLICANT(S)	Nanohmics, Inc. (Austin, Texas)
ASSIGNEE(S)	Nanohmics, Inc. (Austin, Texas)
INVENTOR(S)	Chris W. Mann (Austin, Texas)
ABSTRACT	A tunable notch filter for operation in reflection mode comprises an antenna layer positioned on a transmissive substrate and a mirror layer positioned on a support substrate. The antenna layer and the mirror layer are positioned on opposite sides of a gap and facing each other, the gap having a gap distance. The notch filter is tuned by adjusting the gap distance between the antenna layer and the mirror layer. Tuning the notch filter to a selected state can cause the filter to selectively attenuate the reflection of at least some electromagnetic radiation that is incident on the transmissive substrate and enters the notch filter.
FILED	Wednesday, March 24, 2021
APPL NO	17/210993
ART UNIT	2872 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/12 (20130101) G01J 3/44 (20130101) G01J 3/0227 (20130101) Original (OR) Class G01J 2003/1247 (20130101) Optical Elements, Systems, or Apparatus G02B 5/204 (20130101) G02B 5/284 (20130101)
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11788908 — Methods and apparatuses for quantitative sensing using Rayleigh scattering in optical fiber

US 11788908	Murray et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Matthew J. Murray (Alexandria, Virginia); Brandon Redding (University Park, Maryland); Allen Davis (Falls Church, Virginia); Clay Kirkendall (Fairfax, Virginia)
ABSTRACT	Methods and apparatuses for quantitatively measuring strain in an optical fiber. An optical source comprising an optical beam generator and a pulse generator receives instructions from a controller and generates a pulsed optical beam in response to those instructions. The pulsed optical beam is directed into an optical fiber to generate a reflected beam from scattering centers within the optical fiber. A detector records a plurality of frames of data generated by the reflected beam, and the controller tracks an evolution of a speckle pattern carried by the reflected beam from the plurality of frames and calculates a strain induced in a section of the optical fiber from the evolution of the speckle pattern.
FILED	Monday, September 21, 2020
APPL NO	17/027606
ART UNIT	2874 — Optics
CURRENT CPC	Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/30 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 6/023 (20130101) G02B 6/0288 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/11 (20130101)
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11788941 — Method of using disposable BioMEMS coagulation profiling cartridge

US 11788941	Joseph et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC) Breast Cancer Research Program (USAMRMCBCRP)
APPLICANT(S)	iFirst Medical Technologies, Inc. (Honolulu, Hawaii)
ASSIGNEE(S)	iFirst Medical Technologies, Inc. (Honolulu, Hawaii)
INVENTOR(S)	Luke B. Joseph (Honolulu, Hawaii); Thomas A. Hasling (Honolulu, Hawaii)
ABSTRACT	A handheld medical analyzer works with different disposable application cartridges to perform a variety of interrogations on specimen samples. One application includes attaching a biological microelectromechanical systems (BioMEMS) cartridge that generates blood coagulation profiles indicative of particular forms of coagulation disorders. The device makes coagulopathy testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and permits for a larger number of parallel or serial devices operating simultaneously. One insertion of a cartridge actuates an oscillating circular motion to generate a blood coagulation profile based on a change in rotational motion as blood coagulates in a sample. Change in rotational motion is analyzed through a video camera such as in a smartphone and is plotted to show an amplitude over time. Actuation of the BioMEMS can be achieved by magnetic actuation of a motor controlled by an iPhone or a smart phone to provide a specific rotational pattern.
FILED	Monday, November 02, 2020
APPL NO	17/087518
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) B01L 2300/041 (20130101) B01L 2300/0803 (20130101) B01L 2300/0848 (20130101) B01L 2400/043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/14 (20130101) Original (OR) Class G01N 33/86 (20130101) G01N 2011/147 (20130101) G01N 2800/224 (20130101) G01N 2800/7033 (20130101)
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11789004 — Graphene-based PPB level sulfur detector

US 11789004	Lock et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Evgeniya H. Lock (Annandale, Virginia); F. Keith Perkins (Alexandria, Virginia); Anthony K. Boyd (Arlington, Virginia); Rachael L. Myers-Ward (Springfield, Virginia); David Kurt Gaskill (Alexandria, Virginia); Anindya Nath (Fairfax, Virginia)
ABSTRACT	A sensitive and selective, in-line method to measure and validate the sulfur content at ppb levels in both the liquid and gas phase of an analyte. The method includes patterning graphene, for example to form a mesa structure comprising horizontal or vertical lines or an array of multidentate star features; functionalizing the patterned graphene and attaching nanoparticles to the functionalized graphene to form a device; exposing the device to an analyte in the gas or liquid phase; detecting a change in electrical response when sulfur is present in the analyte; and recovering the device for future use. Also disclosed is the related sulfur detector.
FILED	Monday, April 12, 2021
APPL NO	17/228247
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/127 (20130101) G01N 33/00 (20130101) G01N 33/22 (20130101) G01N 33/0044 (20130101) G01N 33/287 (20130101) Original (OR) Class
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11789160 — Carry-on GPS spoofing detector

US 11789160	Lundberg et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S)	The MITRE Corporation (McLean, Virginia)
INVENTOR(S)	Erik T. Lundberg (Cambridge, Massachusetts); Hugo F. Trappe (Medford, Massachusetts); Christian P D Minor (Bedford, Massachusetts); David Long (Xenia, Ohio)
ABSTRACT	Examples in accordance with this disclosure provide a system for detecting a spoofed signal, the spoofed signal comprising position-navigation-timing (PNT) data. The system can include a first antenna and a second antenna, both configured to receive one or more first signals from one or more navigation satellites. The first antenna and second antenna can be configured to be separated by a first distance. The system can include a first receiver coupled to the first antenna and a second receiver coupled to the second antenna, where each antenna is configured to receive one or more signals from the respective antenna. Each of the first receiver and the second receiver are configured to extract a respective carrier phase data.
FILED	Thursday, August 26, 2021
APPL NO	17/412925
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/29 (20130101) G01S 19/215 (20130101) Original (OR) Class
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11789183 — Independent control of both index and dispersion in gradient index optics

US 11789183	Beadie et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Guy Beadie (Falls Church, Virginia); Richard Flynn (Newbury Park, California); James S. Shirk (Alexandria, Virginia); Joseph Mait (Bethesda, Maryland); Predrag Milojkovic (Bethesda, Maryland)
ABSTRACT	Three or more base optical materials are selectively combined into a trans-gradient index (GRIN) optical element (e.g., a lens). A wavelength-dependent index of refraction for light propagating perpendicular to the three or more optical materials equals: a volume fraction of a first optical material multiplied by a refractive index of the first optical material, plus a volume fraction of a second optical material multiplied by a refractive index of the second optical material, plus one minus the volume fraction of the first optical material and the volume of the second optical material all multiplied by the refractive index of a third optical material. The wavelength-dependent index of refraction distribution and a refractive index dispersion through the GRIN optical element may be independently specified from one another. A local refractive index at any point in the optical element is a fixed function of a refractive index of each individual optical material.
FILED	Tuesday, October 13, 2020
APPL NO	17/069849
ART UNIT	2872 — Optics
CURRENT CPC	Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00355 (20130101) B29D 11/00788 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0087 (20130101) Original (OR) Class Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/028 (20130101)
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11789252 — Optical-inertial stabilization for electro-optical systems

US 11789252	Hilby et al.
FUNDED BY	Department of Defense (DOD) Missile Defense Agency (MDA)
APPLICANT(S)	Lockheed Martin Corporation (Bethesda, Maryland)
ASSIGNEE(S)	Lockheed Martin Corporation (Bethesda, Maryland)
INVENTOR(S)	Timothy Roland Hilby (San Mateo, California); Jesse William Fisher (Boulder, Colorado); Luke L. Wieczorek (Erie, Colorado); Michael L. Tartaglia (Berthoud, Colorado)
ABSTRACT	Provided herein are various improvements to optical-inertial stabilization systems, such as those employed on electro-optical systems that receive or emit optical energy. In one example, a system includes an optical reference element rigidly coupled to a primary mirror. The optical reference element propagates a reference signal through optic elements that form at least a portion of an optical path corresponding to the primary mirror. A measurement of the reference signal is made after propagation through the optic elements to determine errors associated with the optical path. The system can also include inertial sensors rigidly coupled to the primary mirror and optical reference element to form an assembly. The inertial sensors are configured to measure inertial rotation of the assembly. Rotational adjustments about two axes can be produced for the assembly based at least on the inertial rotation properties to correct for disturbance or drift.
FILED	Thursday, October 01, 2020
APPL NO	17/060794
ART UNIT	2872 — Optics
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/5776 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/08 (20130101) Optical Elements, Systems, or Apparatus G02B 26/0816 (20130101) Original (OR) Class
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11789843 — Event detection sensor and recording system

US 11789843	Cridge et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Cornerstone Research Group, Inc. (Miamisburg, Ohio)
ASSIGNEE(S)	Cornerstone Research Group, Inc. (Miamisburg, Ohio)
INVENTOR(S)	Mark Cridge (Miamisburg, Ohio); Trang T. Young (Dayton, Ohio); Matthew Benefiel (Xenia, Ohio); Mitchell Bauer (Beavercreek, Ohio); Gianfranco Trovato (Monroe, Ohio); Kristin M. Cable (Dayton, Ohio)
ABSTRACT	A method of detecting an event and recording quantitative parameters associated with the event is provided. The method includes securing an event detection and recording system on a piece of equipment, the event detection and recording system comprising a plurality of sensors, an internal power source, and a microcontroller. The method further includes activating a low monitoring mode and measuring one or more quantitative parameters with the one or more of the sensors at a first sampling rate to generate low monitoring mode sensor data; analyzing the low monitoring mode sensor data to detect initiation of a triggering event; terminating the low monitoring mode upon detection of the triggering event; and activating a high monitoring mode including measuring and recording one or more quantitative parameters at a second sampling rate, where the second sampling rate is greater than the first sampling rate. The associated system is also provided.
FILED	Wednesday, July 01, 2020
APPL NO	16/918504
ART UNIT	2193 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 11/3072 (20130101) G06F 11/3089 (20130101) Original (OR) Class G06F 11/3476 (20130101) G06F 2201/86 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/118 (20130101) H05K 1/185 (20130101)
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11790141 — Systems and methods for designing integrated circuits

US 11790141	Hills et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Gage Krieger Hills (Mill Valley, California); Max Shulaker (Weston, Massachusetts)
ABSTRACT	System and methods to generate a circuit design for an integrated circuit using only allowable pairs of connected logic stages. The allowable pairs of connected logic stages are those pairs of connected logic stages with a static noise margin (SNM) above an SNM threshold. Also presented is a 16-bit microprocessor made entirely from carbon nanotube field effect transistors (CNFET) having such allowable pair of connected logic stages.
FILED	Wednesday, June 02, 2021
APPL NO	17/336916
ART UNIT	2851 — Printing/Measuring and Testing
CURRENT CPC	Electric Digital Data Processing G06F 30/327 (20200101) Original (OR) Class G06F 30/337 (20200101) G06F 30/392 (20200101) G06F 30/398 (20200101) G06F 2111/04 (20200101) G06F 2119/02 (20200101) G06F 2119/10 (20200101)
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11790213 — Identifying complex events from hierarchical representation of data set features

US 11790213	Yao et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Prostate Cancer Research Program (USAMRMCPCRP) Department of the Interior (DOI) Interior Business Center (IBC)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)	SRI INTERNATIONAL (Menlo Park, California)
INVENTOR(S)	Yi Yao (Princeton, New Jersey); Ajay Divakaran (Monmouth Junction, New Jersey); Pallabi Ghosh (College Park, Maryland)
ABSTRACT	Techniques are disclosed for identifying multimodal subevents within an event having spatially-related and temporally-related features. In one example, a system receives a Spatio-Temporal Graph (STG) comprising (1) a plurality of nodes, each node having a feature descriptor that describes a feature present in the event, (2) a plurality of spatial edges, each spatial edge describing a spatial relationship between two of the plurality of nodes, and (3) a plurality of temporal edges, each temporal edge describing a temporal relationship between two of the plurality of nodes. Furthermore, the STG comprises at least one of: (1) variable-length descriptors for the feature descriptors or (2) temporal edges that span multiple time steps for the event. A machine learning system processes the STG to identify the multimodal subevents for the event. In some examples, the machine learning system comprises stacked Spatio-Temporal Graph Convolutional Networks (STGCNs), each comprising a plurality of STGCN layers.
FILED	Wednesday, June 12, 2019
APPL NO	16/439508
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/045 (20230101) Original (OR) Class
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11790221 — Quantum optical neural networks

US 11790221	Carolan et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Jacques Johannes Carolan (Cambridge, Massachusetts); Gregory R. Steinbrecher (Brookline, Massachusetts); Dirk Robert Englund (Brookline, Massachusetts)
ABSTRACT	Many of the features of neural networks for machine learning can naturally be mapped into the quantum optical domain by introducing the quantum optical neural network (QONN). A QONN can be performed to perform a range of quantum information processing tasks, including newly developed protocols for quantum optical state compression, reinforcement learning, black-box quantum simulation and one way quantum repeaters. A QONN can generalize from only a small set of training data onto previously unseen inputs. Simulations indicate that QONNs are a powerful design tool for quantum optical systems and, leveraging advances in integrated quantum photonics, a promising architecture for next generation quantum processors.
FILED	Monday, March 23, 2020
APPL NO	16/826364
ART UNIT	2123 — AI & Simulation/Modeling
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/35 (20130101) G02F 2203/50 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/067 (20130101) Original (OR) Class G06N 10/00 (20190101)
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11790261 — Tunable coupling between a readout cavity and a parametric amplifier to enhance qubit measurements

US 11790261	Rosenthal et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Multidisciplinary University Research Initiative (MURI) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado); Universitat Innsbruck (Innsbruck, Austria)
ASSIGNEE(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado); Universitat Innsbruck (Innsbruck, Austria)
INVENTOR(S)	Eric Rosenthal (Boulder, Colorado); Konrad Lehnert (Boulder, Colorado); Christian Schneider (Innsbruck, Austria)
ABSTRACT	Technology is disclosed herein that the enhances the measurability and scalability of qubits in a quantum computing environment. In an implementation, a superconducting amplifier device comprises a parametric amplifier and a tunable coupling between the parametric amplifier and a readout cavity external to the superconducting amplifier device. The tunable coupling allows an entangled signal, associated with a qubit in the readout cavity, to transfer from the readout cavity to the parametric amplifier. The parametric amplifier amplifies the entangled signal to produce an amplified signal as output to a measurement sub-system.
FILED	Thursday, March 04, 2021
APPL NO	17/192479
ART UNIT	2851 — Printing/Measuring and Testing
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class Amplifiers H03F 19/00 (20130101)
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11790275 — Adaptive continuous machine learning by uncertainty tracking

US 11790275	Aguilar-Simon et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Teledyne Scientific and Imaging, LLC (Thousand Oaks, California)
ASSIGNEE(S)	TELEDYNE SCIENTIFIC and IMAGING, LLC (Thousand Oaks, California)
INVENTOR(S)	Mario Aguilar-Simon (Chapel Hill, North Carolina); Andrew Paul Brna (Morrisville, North Carolina); Ryan Charles Brown (Raleigh, North Carolina); Patrick Martin Connolly (Cary, North Carolina)
ABSTRACT	Systems and methods for a machine learning system to learn a new skill without catastrophically forgetting an existing skill and to continually learn in a self-supervised manner during operation, without human intervention.
FILED	Friday, April 17, 2020
APPL NO	16/851426
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Electric Digital Data Processing G06F 18/22 (20230101) G06F 18/254 (20230101) G06F 18/2413 (20230101) G06F 18/24317 (20230101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 20/10 (20190101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/70 (20220101) G06V 10/761 (20220101) G06V 10/7788 (20220101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/10 (20130101) G10L 15/30 (20130101) G10L 17/08 (20130101)
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11790280 — Methods of chemical computation

US 11790280	Rubenstein et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	BROWN UNIVERSITY (Providence, Rhode Island)
ASSIGNEE(S)	BROWN UNIVERSITY (Providence, Rhode Island)
INVENTOR(S)	Brenda Rubenstein (Providence, Rhode Island); Jacob Karl Rosenstein (Providence, Rhode Island); Christopher Arcadia (Providence, Rhode Island); Shui Ling Chen (Harrisburg, Pennsylvania); Amanda Doris Dombroski (Cranston, Rhode Island); Joseph D. Geiser (Barrington, Rhode Island); Eamonn Kennedy (West Warwick, Rhode Island); Eunsuk Kim (Providence, Rhode Island); Kady M. Oakley (North Attleboro, Massachusetts); Sherief Reda (Barrington, Rhode Island); Christopher Rose (Providence, Rhode Island); Jason Kelby Sello (Tiverton, Rhode Island); Hokchhay Tann (North Reading, Massachusetts); Peter Weber (Barrington, Rhode Island)
ABSTRACT	The invention provides methods for computing with chemicals by encoding digital data into a plurality of chemicals to obtain a dataset; translating the dataset into a chemical form; reading the data set; querying the dataset by performing an operation to obtain a perceptron; and analyzing the perceptron for identifying chemical structure and/or concentration of at least one of the chemicals, thereby developing a chemical computational language. The invention demonstrates a workflow for representing abstract data in synthetic metabolomes. Also presented are several demonstrations of kilobyte-scale image data sets stored in synthetic metabolomes, recovered at >99% accuracy.
FILED	Monday, July 19, 2021
APPL NO	17/378988
ART UNIT	2123 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 99/007 (20130101) Original (OR) Class
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11791142 — Small gap device system and method of fabrication

US 11791142	Campbell et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Spark Thermionics, Inc. (Berkeley, California); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Spark Thermionics, Inc. (Berkeley, California); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Matthew Campbell (Philadelphia, Pennsylvania); Mohsen Azadi (Philadelphia, Pennsylvania); Kyana Van Houten (Berkeley, California); Jared William Schwede (Berkeley, California); Samuel M. Nicaise (Philadelphia, Pennsylvania); Igor Bargatin (Wynnewood, Pennsylvania)
ABSTRACT	A small-gap device system, preferably including two or more electrodes and one or more spacers maintaining a gap between two or more of the electrodes. A spacer for a small-gap device system, preferably including a plurality of legs defining a mesh structure. A method of spacer and/or small-gap device fabrication, preferably including: defining lateral features, depositing spacer material, selectively removing spacer material, separating the spacer from a fabrication substrate, and/or assembling the small-gap device.
FILED	Friday, January 22, 2021
APPL NO	17/155638
ART UNIT	2834 — Electrical Circuits and Systems
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 9/185 (20130101) H01J 45/00 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/6653 (20130101) H01L 29/6656 (20130101) Electric solid-state devices not otherwise provided for H10N 10/00 (20230201)
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11791378 — Superjunction power semiconductor devices formed via ion implantation channeling techniques and related methods

US 11791378	Van Brunt et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Wolfspeed, Inc. (Durham, North Carolina)
ASSIGNEE(S)	Wolfspeed, Inc. (Durham, North Carolina)
INVENTOR(S)	Edward Robert Van Brunt (Raleigh, North Carolina); Alexander V. Suvorov (Durham, North Carolina); Vipindas Pala (Morrisville, North Carolina); Daniel J. Lichtenwalner (Raleigh, North Carolina); Qingchun Zhang (Cary, North Carolina)
ABSTRACT	Semiconductor devices include a silicon carbide drift region having an upper portion and a lower portion. A first contact is on the upper portion of the drift region and a second contact is on the lower portion of the drift region. The drift region includes a superjunction structure that includes a p-n junction that is formed at an angle of between 10° and 30° from a plane that is normal to a top surface of the drift region. The p-n junction extends within +/−1.5° of a crystallographic axis of the silicon carbide material forming the drift region.
FILED	Friday, July 09, 2021
APPL NO	17/371514
ART UNIT	2892 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/047 (20130101) H01L 29/045 (20130101) H01L 29/0619 (20130101) H01L 29/0634 (20130101) Original (OR) Class H01L 29/0692 (20130101) H01L 29/872 (20130101) H01L 29/1095 (20130101) H01L 29/1608 (20130101) H01L 29/6606 (20130101) H01L 29/7802 (20130101)
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11791454 — Electrochemical formation of substrate coatings

US 11791454	Gallant et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Betar Gallant (Cambridge, Massachusetts); Haining Gao (Cambridge, Massachusetts)
ABSTRACT	Systems, articles, and methods generally related to the electrochemical formation of layers comprising halogen ions on substrates are described.
FILED	Tuesday, June 23, 2020
APPL NO	16/909630
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/045 (20130101) H01M 4/50 (20130101) H01M 4/136 (20130101) H01M 4/388 (20130101) H01M 4/0402 (20130101) H01M 4/1397 (20130101) Original (OR) Class H01M 8/0245 (20130101) H01M 2004/028 (20130101) H01M 2300/0034 (20130101)
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11791510 — Two phase exothermic cooling

US 11791510	Powell et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Research Laboratory (NRL)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Brandon Powell (Washington, District of Columbia); Michael R Dixon, Jr. (Washington, District of Columbia); Jesse Maxwell (Washington, District of Columbia); Rachel Carter (Washington, District of Columbia)
ABSTRACT	A method of cooling a battery cell includes: atomizing a cooling fluid by driving it through a micro-nozzle at a pressure sufficient to create a jet of aerosolized liquid droplets while retaining sufficient momentum in flow of the fluid to travel from the nozzle to an outer surface of the battery cell; impinging the spray of the jet of aerosolized liquid droplets on an outer surface of the battery cell; partially evaporating the liquid droplets on the outer surface to conduct heat from the outer surface; and convecting heat from the outer surface of the battery via the cooling fluid.
FILED	Thursday, April 16, 2020
APPL NO	16/851016
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Come into Direct Contact Without Chemical Interaction F28C 3/00 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/02 (20130101) F28D 2021/0043 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/613 (20150401) H01M 10/6563 (20150401) H01M 10/6567 (20150401) H01M 10/6569 (20150401) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/10 (20130101)
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11791566 — Extremely electrically small antennas based on multiferroic materials

US 11791566	Sepulveda et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Abdon E. Sepulveda (Los Angeles, California); Gregory P. Carman (Los Angeles, California); Jinzhao Hu (Los Angeles, California); Joseph Devin Schneider (Los Angeles, California); Elmer Wu (Rowland Heights, California); Zhi Yao (Los Angeles, California); Sidhant Tiwari (Riverside, California); Wenzhong Yan (Los Angeles, California)
ABSTRACT	A multiferroic antenna apparatus and method are described which provides increased energy efficiencies and ease of implementation. Magnetoelastic and/or magnetostrictive resonator are coupled to a piezoelectric substrate, along with electrodes coupled to its opposing surfaces. In receive mode the resonators create mechanical waves in response to being excited into magnetic oscillation by receiving electromagnetic radiation, and these mechanical waves coupled to the piezoelectric substrate causing it to generate an electrical output signal at said electrodes. In transmit mode an electrical signal coupled through the electrodes induces mechanical waves in the piezoelectric substrate directed to the resonators which are excited into magnetic oscillation to output electromagnetic waves.
FILED	Thursday, February 04, 2021
APPL NO	17/168048
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 3/44 (20130101) H01Q 21/067 (20130101) Original (OR) Class
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11791570 — Grating lobe cancellation

US 11791570	Chieh
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Information Warfare Center (NIWC) Naval Information Warfare Center Pacific (NIWCPACIFIC)
APPLICANT(S)	Naval Information Warfare Center Pacific (San Diego, California)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Jia-Chi Samuel Chieh (San Diego, California)
ABSTRACT	A method for radiating a co-located antenna including radiating the co-located antenna using a dual mode, where the co-located antenna has an inter-element spacing of about 1λ, and the dual mode includes a TM₁₁mode and a TM₂₁mode. The TM₁₁mode is radiated to generate a TM₁₁far field pattern, where the TM₁₁mode has a broadside pattern characterized with a beam peak at broadside and the TM₁₁mode produces grating lobes in addition to the beam peak at broadside. The TM₂₁mode is radiated to generate a TM₂₁far field pattern orthogonal to the TM₁₁far field pattern, thereby causing the TM₂₁mode to produce a null at broadside to suppress the grating lobes produced by the TM₁₁mode.
FILED	Wednesday, July 20, 2022
APPL NO	17/868952
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 5/16 (20130101) Antennas, i.e Radio Aerials H01Q 9/0478 (20130101) H01Q 21/10 (20130101) H01Q 21/293 (20130101) Original (OR) Class
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11791645 — Neuromodulation apparatus, method and system

US 11791645	Muller et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Nia Therapeutics, Inc. (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Nia Therapeutics, Inc. (Radnor, Pennsylvania)
INVENTOR(S)	Rikky Muller (San Francisco, California); Benjamin Johnson (Boise, Idaho); Igor Izyumin (Oakland, California)
ABSTRACT	Representative methods, apparatus and systems are disclosed for providing concurrent electrical stimulation and electrical recording in a human or non-human subject, such as for neuromodulation, with the apparatus coupleable to an electrode array. A representative apparatus is typically an integrated circuit including: stimulation circuits, recording circuits, and blocking circuits responsive to control signals to block the stimulation voltage or current on an electrode from a corresponding recording circuit, while other recording circuits may simultaneously record electrical signals from other electrodes and generate recorded data. A representative stimulation circuit may include current sources; a first multiplexer for current source selection; a second multiplexer for electrode selection; a switchable voltage offset circuit; a switchable grounding circuit; and a stimulation controller providing control signals to provide the electrical stimulation, such as biphasic or monophasic stimulation, and bipolar or unipolar stimulation. Off-chip communication, control, along with power and voltage level control, are also provided.
FILED	Wednesday, March 16, 2022
APPL NO	17/696182
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/291 (20210101) A61B 5/4094 (20130101) A61B 5/4836 (20130101) A61B 5/6868 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36125 (20130101) A61N 1/36139 (20130101) A61N 1/36157 (20130101) A61N 1/36167 (20130101) A61N 1/37223 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 1/082 (20200101) H02J 7/00 (20130101) H02J 7/0025 (20200101) H02J 7/0063 (20130101) Original (OR) Class H02J 50/20 (20160201) H02J 2207/20 (20200101)
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11791809 — Frequency selective limiter having reduced spike leakage

US 11791809	Gillette et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Systems Command (NAVAIR) Naval Air Warfare Center Aircraft Division (NAWCAD) Naval Air Warfare Center (NAWC)
APPLICANT(S)	Metamagnetics, Inc. (Westborough, Massachusetts)
ASSIGNEE(S)	Metamagnetics, Inc. (Marlborough, Massachusetts)
INVENTOR(S)	Scott M. Gillette (Norfolk, Massachusetts); Mahima Shukla (Westborough, Massachusetts)
ABSTRACT	Described is a frequency selective limiter (FSL) module comprising a cascade of an FSL and a functional limiter (e.g. a conventional semiconductor limiter comprising a PIN diode) with steady state limiting and power threshold values selected such the FSL module provides suppression of a spike leakage power and while still enabling frequency selective limiting.
FILED	Thursday, September 30, 2021
APPL NO	17/490865
ART UNIT	2849 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/00 (20130101) Pulse Technique H03K 5/08 (20130101) Original (OR) Class
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11791867 — Space-time encoding in wireless communication systems

US 11791867	Lanham et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	S. Andrew Lanham (Austin, Texas); Travis Cuvelier (Austin, Texas); Brian R. La Cour (Austin, Texas); Robert Heath (Raleigh, North Carolina)
ABSTRACT	A disclosed transmitter for wireless communication includes multiple transmitting antennas, a symbol mapper for mapping an input block including multiple binary bits and representing information to be transmitted to a symbol representing an ordered plurality of complex numbers, a space-time encoder for applying an encoding operator to the symbol to produce a vectorized space-time codeword defining electrical signals to be transmitted by the transmitter, the encoding operator being dependent on a set of predefined stabilizer generators, and circuitry to collectively transmit, by the antennas to multiple receiving antennas of a receiver over a wireless transmission channel, the electrical signals defined by the vectorized space-time codeword. The receiver includes a space-time decoder for recovering the symbol from the electrical signals transmitted by the transmitter using a decoding operation that is based on maximum likelihood inference, and a symbol de-mapper for recovering the input block from the symbol.
FILED	Wednesday, December 29, 2021
APPL NO	17/565286
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 7/0413 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0014 (20130101) Wireless Communication Networks H04W 72/046 (20130101) H04W 72/0466 (20130101)
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11791980 — Zero-loss merging of distributed ledgers

US 11791980	Kaddoura
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	ARCHITECTURE TECHNOLOGY CORPORATION (Eden Prairie, Minnesota)
ASSIGNEE(S)
INVENTOR(S)	Maher N. Kaddoura (Maple Grove, Minnesota)
ABSTRACT	A program product comprising a non-transitory processor readable medium having software stored thereon. The software, when executed by one or more processing devices, is configured to merge a first distributed ledger with a second distributed ledger to form a merged ledger. The first ledger consists of a first beginning subset of blocks followed by a first end subset of blocks. The second ledger consists of a second beginning subset of blocks followed by a second end subset of blocks. The first beginning subset of blocks is identical to the second beginning subset of blocks and the first end subset of blocks is different than the second end subset of blocks. The merged ledger includes the first beginning subset of blocks followed by blocks corresponding to the first end subset of blocks and the second end subset of blocks.
FILED	Friday, August 28, 2020
APPL NO	17/006064
ART UNIT	2167 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/2379 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/382 (20130101) G06Q 2220/00 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/50 (20220501) H04L 9/0637 (20130101) Original (OR) Class H04L 9/3236 (20130101) H04L 9/3297 (20130101)
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11792061 — Estimating frequency-offsets and multi-antenna channels in MIMO OFDM systems

US 11792061	Giannakis et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (, None)
INVENTOR(S)	Georgios B. Giannakis (Minnetonka, Minnesota); Xiaoli Ma (Auburn, Alabama)
ABSTRACT	Techniques are described for carrier frequency offset (CFO) and channel estimation of orthogonal frequency division multiplexing (OFDM) transmissions over multiple-input multiple-output (MIMO) frequency-selective fading channels. A wireless transmitter forms blocks of symbols by inserting training symbols within two or more blocks of information-bearing symbols. The transmitter applies a hopping code to each of the blocks of symbols to insert a null subcarrier at a different position within each of the blocks of symbols, and a modulator outputs a wireless signal in accordance with the blocks of symbols. A receiver receives the wireless signal and estimates the CFO, and outputs a stream of estimated symbols based on the estimated CFO.
FILED	Wednesday, April 06, 2022
APPL NO	17/714926
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 7/046 (20130101) H04B 7/063 (20130101) H04B 7/066 (20130101) H04B 7/0413 (20130101) Multiplex Communication H04J 11/0063 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0016 (20130101) H04L 25/0202 (20130101) H04L 25/0204 (20130101) H04L 25/0228 (20130101) H04L 25/0242 (20130101) H04L 27/2607 (20130101) H04L 27/2613 (20130101) H04L 27/2626 (20130101) Original (OR) Class H04L 27/2657 (20130101) H04L 27/2671 (20130101) H04L 27/2672 (20130101) H04L 27/2675 (20130101) H04L 27/2692 (20130101) H04L 27/2695 (20130101) H04L 27/26134 (20210101)
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11793076 — Ion-enhanced thermoelectric generator

US 11793076	Howe et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Natick Soldier Systems Center (NSSC) National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	HOWE INDUSTRIES LLC (Scottsdale, Arizona)
ASSIGNEE(S)	HOWE INDUSTRIES LLC (Scottsdale, Arizona)
INVENTOR(S)	Troy Michael Howe (Tempe, Arizona); Steven Daniel Howe (Mesa, Arizona)
ABSTRACT	A thermoelectric converter including a thermoelectric generator and a radiation source. The thermoelectric generator includes a hot source, a cold source, n-type material, and p-type material. The radiation source emits ionizing radiation that increases electrical conductivity. Also detailed is a method of using radiation to reach high efficiency with a thermoelectric converter that includes providing a thermoelectric generator and a radiation source, with the thermoelectric generator including a hot source, a cold source, n-type material, and p-type material, and emitting ionizing radiation with the radiation source to increase the electrical conductivity which strips electrons in the n-type material, the p-type material, or both the n-type material and p-type material from their nuclei with the electrons then free to move within the material.
FILED	Wednesday, March 10, 2021
APPL NO	17/198040
ART UNIT	1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Electric solid-state devices not otherwise provided for H10N 10/13 (20230201) Original (OR) Class H10N 10/17 (20230201) H10N 10/855 (20230201)
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RE049701 — Materials with atomically dispersed chemical moieties

US RE49701	Serov et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Alexey Serov (Albuquerque, New Mexico); Plamen Atanassov (Irvine, California)
ASSIGNEE(S)	UNM Rainforest Innovations (Albuquerque, New Mexico)
INVENTOR(S)	Alexey Serov (Albuquerque, New Mexico); Plamen Atanassov (Irvine, California)
ABSTRACT	Synthetic materials that are useful as heterogeneous catalysts or electrocatalysts. The materials can be used to catalyze oxidation and/or reduction reactions and/or oxygen/hydrogen evolution/oxydation reactions.
FILED	Thursday, May 14, 2020
APPL NO	15/929642
ART UNIT	3991 — Central Reexamination Unit (Chemical)
CURRENT CPC	Separation B01D 53/326 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/087 (20130101) B01J 31/12 (20130101) B01J 2219/0803 (20130101) B01J 2219/0875 (20130101) B01J 2219/0877 (20130101) B01J 2219/0892 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/4672 (20130101) C02F 1/4676 (20130101) C02F 1/46109 (20130101) C02F 2001/46142 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/00 (20130101) C25B 1/04 (20130101) C25B 3/25 (20210101) C25B 11/04 (20130101) C25B 11/051 (20210101) C25B 11/057 (20210101) C25B 11/095 (20210101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/36 (20130101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 10/37 (20150501)
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Department of Energy (DOE)

11785943 — Tunable nanotextured materials

US 11785943	Laible et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	Philip D. Laible (Villa Park, Illinois); Martyna Michalska (Lemont, Illinois); Philippe Noirot (Lemont, Illinois); Ralu Divan (Darien, Illinois); Igor Aronson (Lemont, Illinois); Andrey Sokolov (Lemont, Illinois)
ABSTRACT	A material with nanopillar structures extending from a substrate. The nanopillars are engageable by organisms to cause an interaction, such as cellular destruction.
FILED	Friday, September 21, 2018
APPL NO	16/138948
ART UNIT	1781 — Miscellaneous Articles, Stock Material
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/34 (20130101) Original (OR) Class A01N 25/34 (20130101) A01N 59/00 (20130101) A01N 59/00 (20130101) A01N 59/10 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 2300/161 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 2203/0361 (20130101) B81B 2203/0392 (20130101) Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 3/0014 (20130101) B82B 3/0019 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 30/00 (20130101) B82Y 40/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6806 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24182 (20150115) Y10T 428/24355 (20150115) Y10T 428/24479 (20150115)
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11786597 — Ionic liquids for transdermal drug delivery

US 11786597	Zakrewsky et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	The Regents of the University of California (Oakland, California); Triad National Security, LLC (Los Alamos, New Mexico); Arizona Board of Regents (Flagstaff, Arizona)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico); THE ARIZONA BOARD OF REGENTS (Flagstaff, Arizona)
INVENTOR(S)	Michael Zakrewsky (San Diego, California); Samir Mitragotri (Lexington, Massachusetts); David T. Fox (Los Alamos, New Mexico); Andrew Koppisch (Flagstaff, Arizona); Rico Del Sesto (Ivins, Utah); Katherine Lovejoy (Silver Spring, Maryland)
ABSTRACT	The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders.
FILED	Friday, June 21, 2019
APPL NO	16/448335
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 33/12 (20130101) A01N 33/12 (20130101) A01N 37/02 (20130101) A01N 37/04 (20130101) A01N 37/06 (20130101) A01N 41/06 (20130101) A01N 41/06 (20130101) A01N 43/36 (20130101) A01N 43/36 (20130101) A01N 47/28 (20130101) A01N 49/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/047 (20130101) A61K 31/66 (20130101) A61K 31/545 (20130101) A61K 47/12 (20130101) A61K 47/24 (20130101) Original (OR) Class
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11786883 — Adsorption cooling system using metal organic frameworks

US 11786883	Baumann et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Theodore F. Baumann (Discovery Bay, California); Joe H. Satcher, Jr. (Patterson, California); Joseph C. Farmer (Tracy, California); Todd Bandhauer (Livermore, California)
ABSTRACT	A highly adsorptive structure includes: a substrate; and a metal-organic framework (MOF) comprising a plurality of metal atoms coordinated to a plurality of organic spacer molecules; wherein the MOF is coupled to at least one surface of the substrate, wherein the MOF is configured to adsorb and desorb a refrigerant under predetermined thermodynamic conditions. The refrigerant includes one or more materials selected from the group consisting of: acid halides, alcohols, aldehydes, amines, chlorofluorocarbons, esters, ethers, fluorocarbons, perfluorocarbons, halocarbons, halogenated aldehydes, halogenated amines, halogenated hydrocarbons, halomethanes, hydrocarbons, hydrochlorofluorocarbons, hydrofluoroethers, hydrofluoroolefins, inorganic gases, ketones, nitrocarbon compounds, noble gases, organochlorine compounds, organofluorine compounds, organophosphorous compounds, organosilicon compounds, oxide gases, refrigerant blends and thiols.
FILED	Thursday, March 11, 2021
APPL NO	17/199251
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/3265 (20130101) B01J 20/28042 (20130101) B01J 20/28066 (20130101) B01J 20/28097 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 15/00 (20130101) F25B 17/083 (20130101)
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11786886 — Catalysts and methods for the conversion of carbonaceous materials to liquid fuels

US 11786886	Vardon et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S)	Derek Richard Vardon (Lakewood, Colorado); Huong Thi Thanh Nguyen (Denver, Colorado)
ABSTRACT	The present disclosure relates to a composition that includes copper (Cu), aluminum (Al), oxygen, and an element (M) that includes at least one of magnesium, cerium, and/or a transition metal, where the copper and the element are present at a first molar ratio relative to the aluminum between about 0.1:1 and about 30:1 ((Cu+M):Al), and the copper and the element are present at a second molar ratio between about 0.1:4 and about 20:1 (Cu:M).
FILED	Monday, March 01, 2021
APPL NO	17/188334
ART UNIT	1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/83 (20130101) Original (OR) Class B01J 35/1014 (20130101) B01J 35/1019 (20130101) B01J 35/1038 (20130101) B01J 35/1042 (20130101) B01J 35/1047 (20130101) B01J 35/1057 (20130101) B01J 35/1061 (20130101) B01J 35/1066 (20130101) Acyclic or Carbocyclic Compounds C07C 29/132 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/02 (20130101) C10L 2200/0469 (20130101)
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11787085 — Methods of making and using bulk products including fiber-containing particles with dual-tapered shape

US 11787085	Harris et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	VARTEGA INC. (Denver, Colorado)
ASSIGNEE(S)	Vartega Inc. (Denver, Colorado)
INVENTOR(S)	Jordan Gray Harris (Arvada, Colorado); Kylie Marie Van Aken (Edgewater, Colorado); Sean Paul Kline (Littleton, Colorado); Andrew Timothy Maxey (Arvada, Colorado); Sean Louis Hankins (Jacksonville, Florida)
ABSTRACT	Recycled carbon fibers are processed by rotational tumbling in a mixture with binder material to prepare fiber-containing particles having a dual-tapered shape and general alignment of fibers with a longitudinal direction of the particles. Bulk products including such fiber-containing particles are compounded with polymer and pelletized to prepare fiber-reinforced composite pellets, which are useful for applications such as injection molding to prepare molded products of carbon fiber-reinforced composite material with recycled carbon fibers.
FILED	Thursday, February 17, 2022
APPL NO	17/674089
ART UNIT	1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 9/06 (20130101) B29B 9/14 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 45/0005 (20130101) B29C 2045/001 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/12 (20130101)
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11787697 — Compositions having reduced thermal conductivities and methods of making the same

US 11787697	Blackburn et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado); The University of Denver (Denver, Colorado)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado); University of Denver (Denver, Colorado)
INVENTOR(S)	Jeffrey Lee Blackburn (Golden, Colorado); Andrew John Ferguson (Louisville, Colorado); Barry Lee Zink (Denver, Colorado)
ABSTRACT	The present disclosure relates to a composition that includes a film having a network of randomly aligned carbon nanotubes, where the carbon nanotubes have an average diameter between about 0.6 nm and about 2.0 nm and the carbon nanotubes form bundles having an average diameter between about 3 nm and about 50 nm. In addition, the composition is characterized by a power factor α²σ between 1 μW/mK²and about 3500 μW/mK²and by ZT=α²σT/k between about 0.02 and about 2.0 over a temperature range between about 100 K and about 500 K.
FILED	Tuesday, September 14, 2021
APPL NO	17/474409
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/882 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/162 (20170801) C01B 32/168 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/52 (20130101) C01P 2004/13 (20130101)
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11787727 — Method for fabrication of sleeveless photonic crystal canes with an arbitrary shape

US 11787727	Drachenberg et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Derrek Reginald Drachenberg (Livermore, California); Michael J. Messerly (Danville, California); Paul H. Pax (Livermore, California); John B. Tassano, Jr. (Manteca, California)
ABSTRACT	The fabrication of sleeveless canes utilizes a preform with an array of glass canes in the preform. At least one tube-sleeve encircles the array of glass canes and is secured to the array of glass canes. The array of glass canes is moved into a furnace wherein the array of glass canes is heated. The furnace is maintained at a furnace temperature within the range of 2000° C. to 1700° C. and the array of glass canes is drawn from the furnace. The drawing of the array of glass canes both scales down the glass canes and elongates the glass canes. Maintaining the furnace at a furnace temperature within the range of 2000° C. to 1700° C. assures that the array of glass canes and the glass canes maintain their original shape.
FILED	Wednesday, April 18, 2018
APPL NO	15/956018
ART UNIT	1741 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Manufacture, Shaping, or Supplementary Processes C03B 37/03 (20130101) C03B 37/032 (20130101) C03B 37/0122 (20130101) C03B 37/0279 (20130101) C03B 37/01208 (20130101) C03B 37/02736 (20130101) Original (OR) Class C03B 37/02781 (20130101) C03B 2203/42 (20130101) C03B 2205/60 (20130101)
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11787912 — Highly filled carbon nanofiber reinforced polysiloxanes

US 11787912	Robison et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Kansas City National Security Campus (KCNSC) NNSA Critical Mission Site Operated by Honeywell Federal Manufacturing and Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S)	Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S)	Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S)	Thomas Wayne Robison (Kansas City, Missouri); Sabrina M. Torres (Kansas City, Missouri); Andrea Labouriau (Kansas City, Missouri)
ABSTRACT	Provided herein are polysiloxane-based composite materials comprising a high weight percentage of elemental components (e.g., elemental boron, elemental copper, elemental bismuth, elemental lead) and low levels of carbon nanofibers. The elemental components may be present in the composite materials at levels greater than 25% by weight. Also provided herein are methods of forming the composite materials that have desirable flexibility and shielding properties. The invention provides a versatile composite material that is compliant and moldable, while still comprising high levels of the elemental shielding components. The materials are particularly useful for applications in which radiation shielding or neutron capture are desired.
FILED	Wednesday, August 01, 2018
APPL NO	16/052217
ART UNIT	1786 — Miscellaneous Articles, Stock Material
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/12 (20130101) C08G 77/20 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/20 (20130101) C08J 5/042 (20130101) Original (OR) Class C08J 2383/04 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/02 (20130101) C08K 3/02 (20130101) C08K 3/04 (20130101) C08K 3/04 (20130101) C08K 3/38 (20130101) C08K 3/38 (20130101) C08K 3/046 (20170501) C08K 3/046 (20170501) C08K 2003/085 (20130101) C08K 2003/0837 (20130101) Compositions of Macromolecular Compounds C08L 83/04 (20130101) C08L 83/04 (20130101) C08L 83/04 (20130101) C08L 83/04 (20130101) C08L 83/04 (20130101)
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11787947 — Dyes in dye aggregate systems—engineering J, K, and dye packing

US 11787947	Knowlton et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Boise State University (Boise, Idaho)
ASSIGNEE(S)	Boise State University (Boise, Idaho)
INVENTOR(S)	William B. Knowlton (Boise, Idaho); Bernard Yurke (Boise, Idaho); Ryan D. Pensack (Boise, Idaho); Paul H. Davis (Boise, Idaho)
ABSTRACT	The present disclosure is directed to designing dyes and methods to alter the parameters controlling the dipole-dipole coupling of dyes bound to a nucleotide oligomer architecture, which are used to propagate excitons for use in next generation room temperature quantum information systems. The disclosed dyes and methods are directed to changing the dye stability, symmetry, overlap, and steric hindrance of the dyes to fine tune aggregate systems.
FILED	Friday, January 10, 2020
APPL NO	16/739963
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 69/105 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) C12Q 2561/12 (20130101)
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11788002 — Fluorescent conjugated polymers containing semi-ladder units for light-emitting field-effect transistors

US 11788002	Yu et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	University of Chicago (Chicago, Illinois)
ASSIGNEE(S)	THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
INVENTOR(S)	Luping Yu (Chicago, Illinois); Mohammad A. Awais (Chicago, Illinois); Valerii Sharapov (Chicago, Illinois); Dafei Yuan (Chicago, Illinois)
ABSTRACT	Materials are provided for use as active emissive layers in organic electronic devices such as light-emitting filed effect transistors. Light-emitting transistors (LET) are an alternative to light-emitting diodes and have several important benefits, however, materials developed specifically for LET are quite scarce. Herein a new family of materials is disclosed that has been developed specifically for LET.
FILED	Friday, November 13, 2020
APPL NO	17/097731
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/07 (20130101) Original (OR) Class C09K 2211/104 (20130101) C09K 2211/1011 (20130101) Organic electric solid-state devices H10K 50/16 (20230201) H10K 50/171 (20230201) H10K 85/615 (20230201) H10K 85/6572 (20230201)
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11788092 — Recombinant microorganisms and uses therefor

US 11788092	Liew et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	LanzaTech, Inc. (Skokie, Illinois)
ASSIGNEE(S)	LanzaTech, Inc. (Skokie, Illinois)
INVENTOR(S)	Fungmin Liew (Chicago, Illinois); Michael Koepke (Chicago, Illinois)
ABSTRACT	Microorganisms are genetically engineered to produce 3-hydroxypropionate (3-HP). The microorganisms are carboxydotrophic acetogens. The microorganisms produce acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/CO₂. A β-alanine pyruvate aminotransferase from a microorganism that contains such an enzyme is introduced. Additionally, an acetyl-coA carboxylase may also be introduced. The production of 3-HP can be improved. This can be effected by improved promoters or higher copy number or enzymes that are catalytically more efficient.
FILED	Monday, February 07, 2022
APPL NO	17/650191
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/93 (20130101) C12N 9/1096 (20130101) C12N 15/52 (20130101) Original (OR) Class C12N 15/74 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/18 (20130101) C12P 7/42 (20130101) Enzymes C12Y 101/01001 (20130101) C12Y 102/01075 (20130101) C12Y 102/07005 (20130101) C12Y 206/01018 (20130101) C12Y 604/01002 (20130101)
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11788111 — Compositions and methods for making selenocysteine containing polypeptides

US 11788111	Soll et al.
FUNDED BY	Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	YALE UNIVERSITY (New Haven, Connecticut)
INVENTOR(S)	Dieter Soll (Guilford, Connecticut); Takahito Mukai (New Haven, Connecticut); Kyle Hoffman (New Haven, Connecticut)
ABSTRACT	Non-naturally occurring tRNA^Secand methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring tRNA^Seccan be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the requirement of an SECIS element. In some embodiments, selenocysteine containing polypeptides are manufactured by co-expressing a non-naturally occurring tRNA^Seca recombinant expression system, such as E. coli, with SerRS, EF-Tu, SelA, or PSTK and SepSecS, and an mRNA with at least one codon that recognizes the anticodon of the non-naturally occurring tRNA^Sec.
FILED	Thursday, October 04, 2018
APPL NO	16/754130
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 209/01001 (20130101)
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11788171 — Methods of recovering an elemental rare earth metal, and methods of forming a rare earth metal

US 11788171	Case et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE) Idaho National Laboratory (INL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
INVENTOR(S)	Mary E. Case (Idaho Falls, Idaho); Robert V. Fox (Idaho Falls, Idaho); Donna L. Baek (Idaho Falls, Idaho)
ABSTRACT	A method of recovering an elemental rare earth metal comprises placing a rare earth-containing material comprising a rare earth metal in a reaction solution comprising a reducing agent and a non-aqueous solvent comprising an ionic liquid or a eutectic mixture, reducing the rare earth metal with the reducing agent to form a metallic rare earth metal and cations of the reducing agent, transferring the cations of the reducing agent from the reaction solution to an electrochemical cell through an ion exchange membrane, and reducing the cations of the reducing agent in the electrochemical cell. Related methods of forming an elemental rare earth metal, and related systems are disclosed.
FILED	Thursday, February 25, 2021
APPL NO	17/249283
ART UNIT	1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/10 (20200101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 59/00 (20130101) Original (OR) Class Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/22 (20130101) C25C 3/00 (20130101) C25C 3/34 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/665 (20130101)
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11788207 — Methods and systems for electrospinning using low power voltage converter

US 11788207	Bidhar
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Fermi National Accelerator Laboratory (FNAL) Federally Funded Research and Development Center (FFRDC) Operated by Fermi Research Alliance, LLC (FRA) at Batavia, IL
APPLICANT(S)	Fermi Research Alliance, LLC (Batavia, Illinois)
ASSIGNEE(S)	Fermi Research Alliance, LLC (Batavia, Illinois)
INVENTOR(S)	Sujit Bidhar (Carol Stream, Illinois)
ABSTRACT	An electrospinning system, method, and apparatus comprises a dual polarity high voltage power supply with much less power out for safe operation, a solution dispensing assembly held at high positive potential by the dual polarity power supply, a Corona discharge assembly held at high negative potential by the dual polarity power supply, and a drum collector held at ground potential wherein a solution is drawn from the solution dispensing assembly to the drum collector thereby forming a fiber mat.
FILED	Friday, October 15, 2021
APPL NO	17/502611
ART UNIT	1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0038 (20130101) D01D 5/0061 (20130101) D01D 5/0069 (20130101) D01D 5/0076 (20130101) D01D 5/0084 (20130101) Original (OR) Class D01D 5/0092 (20130101) D01D 10/00 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/09 (20130101) D01F 6/94 (20130101)
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11788320 — Protective barriers and related methods

US 11788320	Bratton et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE) Idaho National Laboratory (INL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
INVENTOR(S)	Kenneth R. Bratton (Idaho Falls, Idaho); Teddy R. Reed (Idaho Falls, Idaho); Henry S. Chu (Idaho Falls, Idaho); Todd L. Johnson (Shelley, Idaho)
ABSTRACT	Corner assemblies for protective barriers for protecting assets (e.g., electrical power transformers and other substation components). The corner assembly includes two guide structures oriented perpendicular to each other. The corner assembly includes at least two protective member assemblies disposed within the two guide structures. Each protective member assembly includes two side members within protective members extending horizontally between the two side members.
FILED	Wednesday, March 03, 2021
APPL NO	17/249510
ART UNIT	3678 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General E04H 5/04 (20130101) E04H 17/009 (20210101) E04H 17/166 (20130101) Original (OR) Class Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/24 (20130101) Boards, Substations, or Switching Arrangements for the Supply or Distribution of Electric Power H02B 5/00 (20130101)
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11788722 — Flame stabilizer for natural draft lean premixed burner apparatus

US 11788722	Rapp et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Vi Rapp (Berkeley, California); Peter Therkelsen (Portland, Oregon)
ABSTRACT	This disclosure provides systems, methods, and apparatus related to burner apparatus for lean premixed flames. In one aspect, an apparatus includes a burner plate, a burner body, and a mesh. A first surface of the burner plate defines a combustion surface for a fuel/air mixture. The burner plate defines a plurality of primary ports. The burner body defines a fuel-air mixing chamber. One surface of the burner body comprises the burner plate. The burner body defines an inlet for receiving air and a fuel in the fuel-air mixing chamber. The mesh is disposed in the fuel-air mixing chamber and is in contact with a second surface of the burner plate.
FILED	Wednesday, February 10, 2021
APPL NO	17/172298
ART UNIT	3762 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Burners F23D 14/02 (20130101) F23D 14/26 (20130101) Original (OR) Class F23D 14/62 (20130101) F23D 2203/102 (20130101)
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11788734 — System and method for combined heat and electric power generation

US 11788734	Lorimer et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Spark Thermionics, Inc. (Berkeley, California)
ASSIGNEE(S)	Spark Thermionics, Inc. (Berkeley, California)
INVENTOR(S)	Adam G. Lorimer (Berkeley, California); Jared William Schwede (Berkeley, California)
ABSTRACT	A system for combined heat and electric power generation, preferably including a heat reservoir and one or more electric generators, each preferably including a heat source and an energy converter. A method for combined heat and electric power generation, preferably including activating an electric generator, deactivating the electric generator, and/or providing heat from a heat reservoir.
FILED	Friday, August 06, 2021
APPL NO	17/395998
ART UNIT	2834 — Electrical Circuits and Systems
CURRENT CPC	Domestic- or Space-heating Systems, e.g Central Heating Systems; Domestic Hot-water Supply Systems; Elements or Components Therefor F24D 18/00 (20220101) Original (OR) Class F24D 2101/60 (20220101) F24D 2103/17 (20220101) Electric Machines Not Otherwise Provided for H02N 10/00 (20130101)
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11788793 — Recuperator with balanced and floating core

US 11788793	Kelly et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Kevin Kelly (Baton Rouge, Louisiana); Cole Doiron (Denham Springs, Louisiana)
ASSIGNEE(S)
INVENTOR(S)	Kevin Kelly (Baton Rouge, Louisiana); Cole Doiron (Denham Springs, Louisiana)
ABSTRACT	A microtube recuperator for transferring heat between a high pressure fluid stream and a low pressure fluid.
FILED	Friday, March 26, 2021
APPL NO	17/213479
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 7/1669 (20130101) Original (OR) Class F28D 21/0001 (20130101)
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11788893 — Nanoscale bolometer operating near the thermodynamic limit

US 11788893	Harris et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Charles Thomas Harris (Albuquerque, New Mexico); Tzu-Ming Lu (Albuquerque, New Mexico); Ting S. Luk (Albuquerque, New Mexico); Peter Anand Sharma (Albuquerque, New Mexico)
ABSTRACT	A nanoscale bolometer for infrared (IR) thermal imaging comprises a subwavelength antenna that provides a specific detectivity approaching a fundamental, thermodynamic limit. The uncooled nanobolometer achieves performance comparable to cooled, high-performance, semiconductor photodetectors, but with significantly reduced size, weight, power, and cost.
FILED	Tuesday, April 12, 2022
APPL NO	17/718778
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/20 (20130101) G01J 5/024 (20130101) G01J 5/0215 (20130101) Original (OR) Class G01J 5/0837 (20130101) G01J 5/0853 (20130101)
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11789333 — System and method for temporal dispersion compensator

US 11789333	Panas et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California); Bright Silicon Technologies, Inc. (San Francisco, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California); Bright Silicon Technologies, Inc. (San Francisco, California)
INVENTOR(S)	Robert Matthew Panas (Dublin, California); Frank Ravizza (Brentwood, California); Robert McHenry (San Francisco, California)
ABSTRACT	The present disclosure relates to a system for modifying temporal dispersion in an optical signal. The system makes use of a segmented array including a plurality of independently controllable, reflective optical elements. The optical elements are configured to segment a received input optical signal into a plurality of beamlets, and to reflect and steer selected ones of the plurality of beamlets in predetermined angular orientations therefrom. A variable optical dispersion subsystem is used which has a plurality of optical components configured to receive and impart different predetermined time delays to different ones of the received beamlets, and to output the plurality of beamlets therefrom.
FILED	Monday, March 01, 2021
APPL NO	17/188656
ART UNIT	2872 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 27/123 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/292 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) H01S 3/0071 (20130101)
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11789453 — Apparatus and method for agricultural data collection and agricultural operations

US 11789453	Chowdhary et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E) National Science Foundation (NSF) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Girish Chowdhary (Champaign, Illinois); Chinmay P. Soman (Urbana, Illinois); Erkan Kayacan (Champaign, Illinois); Benjamin C. Thompson (Champaign, Illinois); Zhongzhong Zhang (Urbana, Illinois); Anwesa Choudhuri (West Bengal, India)
ABSTRACT	Aspects of the subject disclosure may include, for example, obtaining video data from a single monocular camera, wherein the video data comprises a plurality of frames, wherein the camera is attached to a mobile robot that is travelling along a lane defined by a row of crops, wherein the row of crops comprises a first plant stem, and wherein the plurality of frames include a depiction of the first plant stem; obtaining robot velocity data from encoder(s), wherein the encoder(s) are attached to the robot; performing foreground extraction on each of the plurality of frames of the video data, wherein the foreground extraction results in a plurality of foreground images; and determining, based upon the plurality of foreground images and based upon the robot velocity data, an estimated width of the first plant stem. Additional embodiments are disclosed.
FILED	Friday, August 24, 2018
APPL NO	16/641618
ART UNIT	2645 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Systems for Controlling or Regulating Non-electric Variables G05D 1/0246 (20130101) Original (OR) Class Electric Digital Data Processing G06F 18/2155 (20230101) Computer Systems Based on Specific Computational Models G06N 20/10 (20190101) Image or Video Recognition or Understanding G06V 20/41 (20220101) G06V 20/188 (20220101) Wireless Communication Networks H04W 4/40 (20180201)
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11789769 — System and method for generation of event driven, tuple-space based programs

US 11789769	Baskaran et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	QUALCOMM TECHNOLOGIES, INC. (San Diego, California)
ASSIGNEE(S)	QUALCOMM Incorporated (San Diego, California)
INVENTOR(S)	Muthu M. Baskaran (Old Tappan, New Jersey); Thomas Henretty (Brooklyn, New York); M. H. Langston (Beacon, New York); Richard A. Lethin (New York, New York); Benoit J. Meister (New York, New York); Nicolas T. Vasilache (New York, New York); David E. Wohlford (Portland, Oregon)
ABSTRACT	In a system for automatic generation of event-driven, tuple-space based programs from a sequential specification, a hierarchical mapping solution can target different runtimes relying on event-driven tasks (EDTs). The solution uses loop types to encode short, transitive relations among EDTs that can be evaluated efficiently at runtime. Specifically, permutable loops translate immediately into conservative point-to-point synchronizations of distance one. A runtime-agnostic which can be used to target the transformed code to different runtimes.
FILED	Friday, February 14, 2020
APPL NO	16/791361
ART UNIT	2195 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 9/4843 (20130101) Original (OR) Class
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11789811 — Techniques for storing data to enhance recovery and detection of data corruption errors

US 11789811	Mills et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Nvidia Corporation (Santa Clara, California)
ASSIGNEE(S)	NVIDIA Corporation (Santa Clara, California)
INVENTOR(S)	Peter Mills (Santa Clara, California); Michael Sullivan (Santa Clara, California); Nirmal Saxena (Santa Clara, California); John Brooks (Santa Clara, California)
ABSTRACT	Often there are errors when reading data from computer memory. To detect and correct these errors, there are multiple types of error correction codes. Disclosed is an error correction architecture that creates a codeword having a data portion and an error correction code portion. Swizzling rearranges the order of bits and distributes the bits among different codewords. Because the data is redistributed, a potential memory error of up to N contiguous bits, where N for example equals 2 times the number of codewords swizzled together, only affects up to, at most, two bits per swizzled codeword. This keeps the error within the error detecting capabilities of the error correction architecture. Furthermore, this can allow improved error correction and detection without requiring a change to error correcting code generators and checkers.
FILED	Tuesday, May 17, 2022
APPL NO	17/746627
ART UNIT	2112 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Electric Digital Data Processing G06F 3/0619 (20130101) G06F 3/0659 (20130101) G06F 3/0673 (20130101) G06F 11/10 (20130101) Original (OR) Class
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11790081 — Systems and methods for controlling an industrial asset in the presence of a cyber-attack

US 11790081	D'Amato et al.
FUNDED BY	Department of Energy (DOE) Office of Electricity (DOE-OE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Fernando Javier D'Amato (Niskayuna, New York); Mustafa Tekin Dokucu (Latham, New York); Hema Kumari Achanta, III (Schenectady, New York); Kalpesh Singal (Ballston Spa, New York); Masoud Abbaszadeh (Clifton Park, New York); Yuh-Shyang Wang (Pittsburgh, Pennsylvania); Karla Kvaternik (Schenectady, New York); Souransu Nandi (Niskayuna, New York); Georgios Boutselis (Niskayuna, New York)
ABSTRACT	Systems and methods are provided for the control of an industrial asset, such as a power generating asset. Accordingly, a cyber-attack model predicts a plurality of operational impacts on the industrial asset resulting from a plurality of potential cyber-attacks. The cyber-attack model also predicts a corresponding plurality of potential mitigation responses. In operation, a cyber-attack impacting at least one component of the industrial asset is detected via the cyber-attack neutralization module and a protected operational impact of the cyber-attack is identified based on the cyber-attack model. The cyber-attack neutralization module selects at least one mitigation response of the plurality of mitigation responses based on the predicted operational impact and an operating state of the industrial asset is altered based on the selected mitigation response.
FILED	Wednesday, April 14, 2021
APPL NO	17/229934
ART UNIT	2193 — Interprocess Communication and Software Development
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Electric Digital Data Processing G06F 9/45508 (20130101) G06F 21/554 (20130101) Original (OR) Class G06F 2221/034 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101)
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11791143 — Small gap device system and method of fabrication

US 11791143	Schwede et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Spark Thermionics, Inc. (Emeryville, California); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Spark Thermionics, Inc. (Berkeley, California); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Jared William Schwede (Emeryville, California); Igor Bargatin (Wynnewood, Pennsylvania); Samuel M. Nicaise (Philadelphia, Pennsylvania); Chen Lin (Santa Clara, California); John Provine (Emeryville, California)
ABSTRACT	A small-gap device system, preferably including two or more electrodes and one or more spacers maintaining a gap between two or more of the electrodes. A spacer for a small-gap device system, preferably including a plurality of legs defining a mesh structure. A method of spacer and/or small-gap device fabrication, preferably including: defining lateral features, depositing spacer material, selectively removing spacer material, separating the spacer from a fabrication substrate, and/or assembling the small-gap device.
FILED	Friday, October 08, 2021
APPL NO	17/497342
ART UNIT	2894 — Semiconductors/Memory
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) Original (OR) Class
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11791477 — Roll-to-roll SOFC manufacturing method and system

US 11791477	Li et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee); Redox Power Systems, LLC (Beltsville, Maryland)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee); REDOX POWER SYSTEMS, LLC (Beltsville, Maryland)
INVENTOR(S)	Jianlin Li (Knoxville, Tennessee); Dhrupadkumar P. Parikh (Knoxville, Tennessee); Thomas Langdo (Great Falls, Virginia); Sean R. Bishop (Albuquerque, New Mexico); Bryan M. Blackburn (Bethesda, Maryland)
ABSTRACT	A method of making a solid oxide fuel cell (SOFC) includes the steps of providing a first SOFC layer laminate tape comprising a first SOFC layer composition attached to a flexible carrier film layer, providing a second SOFC laminate tape comprising a second SOFC layer composition attached to a flexible carrier film layer, and providing a third SOFC layer laminate tape comprising a third SOFC layer composition attached to a flexible carrier film layer. The first SOFC layer laminate tape, the second SOFC layer laminate tape, and the third SOFC layer laminate tape are assembled on rolls positioned along a roll-to-roll assembly line. The laminate tapes are sequentially laminated and calendered and the flexible carrier films removed to provide a composite SOFC precursor laminate that can be sintered and combined with a cathode to provide a completed SOFC. An assembly for making composite SOFC precursor laminates is also disclosed.
FILED	Thursday, December 10, 2020
APPL NO	17/118261
ART UNIT	1728 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8605 (20130101) H01M 8/004 (20130101) Original (OR) Class H01M 8/1226 (20130101) H01M 8/1246 (20130101) H01M 2004/8684 (20130101) H01M 2008/1293 (20130101)
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11791478 — Reduced-temperature sintering of spinel-type coatings and layers with metallic alloy powder precursors

US 11791478	Zhu et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Tennessee Technological University (Cookeville, Tennessee)
ASSIGNEE(S)	Tennessee Technological University (Cookeville, Tennessee)
INVENTOR(S)	Jiahong Zhu (Cookeville, Tennessee); Yutian Yu (Cookeville, Tennessee); Brian Bates (Cookeville, Tennessee)
ABSTRACT	A method of forming a spinel coating on a substrate is disclosed including the steps of coating at least a portion of the substrate with a precursor including an alloy powder, and sintering the precursor at a temperature of less than 1000 degrees Celsius to form the spinel coating. The alloy powder used for the precursor can include particles having a particle size of less than 10 micrometers. The method can be utilized to form spinel coatings as contact surfaces between electrodes and interconnects of solid oxide fuel cell (SOFC) stacks.
FILED	Wednesday, October 07, 2020
APPL NO	17/065158
ART UNIT	1738 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/10 (20220101) B22F 1/054 (20220101) B22F 3/10 (20130101) B22F 3/24 (20130101) B22F 2003/242 (20130101) B22F 2201/03 (20130101) B22F 2301/15 (20130101) B22F 2301/35 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0236 (20130101) Original (OR) Class H01M 8/0245 (20130101) H01M 8/2432 (20160201) H01M 2008/1293 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101)
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11791519 — Biodegradable transient battery built on core-double-shell zinc microparticle networks

US 11791519	Wang et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Xudong Wang (Middleton, Wisconsin); Yutao Dong (Madison, Wisconsin)
ABSTRACT	A transient or biodegradable battery is provided having a filament structure that limits the speed of reaction allowing for a longer duration of battery power with a controlled current limit. In one embodiment, the filament may be constructed of zinc microparticles or nanoparticles having a thin outer insulation whereby a chemical reaction at the center core results in the progressive disintegration of the insulation revealing more core material. In one embodiment, microparticles or nanoparticles are coated with outer layers of chitosan and Al₂O₃nanofilms, respectively, with designable discharge current and battery lifespan by controlling the exposed cross-sectional area of the zinc microparticle center core and the length of the filament, respectively. This novel structure of biodegradable battery provides improved control of battery life and power output, providing a promising solution to power transient medical implants.
FILED	Thursday, October 14, 2021
APPL NO	17/501490
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/622 (20130101) H01M 6/02 (20130101) H01M 6/34 (20130101) H01M 50/107 (20210101) H01M 50/469 (20210101) Original (OR) Class H01M 2004/022 (20130101)
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11791601 — Pulsed source for driving non-linear current dependent loads

US 11791601	Curtis, III
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	William C. Curtis, III (Albuquerque, New Mexico)
ABSTRACT	A pulsed current source comprises a power source, a discharge capacitor, and an inductive element. The discharge capacitor is selectively coupled to either of the power source or the inductive element. When coupled to the power source, the discharge capacitor is charged. The inductive element can be connected to a load. The load can have a current-dependent impedance. When the discharge capacitor is coupled to the inductive element, the discharge capacitor discharges through the inductive element and the load. The discharge capacitor and the inductive element are configured so that the current through the load exhibits a substantially linear rise in a linear operational region. The inductive element is configured to saturate during discharge of the capacitor through the load, so that the saturation of the inductive element causes the current through the load to continue to rise in a substantially linear fashion.
FILED	Tuesday, February 09, 2021
APPL NO	17/171294
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 3/124 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/092 (20130101) H01S 3/0912 (20130101) Original (OR) Class H01S 5/042 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 41/30 (20130101) H05B 46/00 (20200101)
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11791764 — Fluidic actuator system and method

US 11791764	Madrone et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	SUNFOLDING, INC. (San Francisco, California)
ASSIGNEE(S)	SUNFOLDING, INC. (San Francisco, California)
INVENTOR(S)	Leila Marcia Madrone (San Francisco, California); Kyle Douglas Betts (San Francisco, California); Peter Sturt Lynn (Oakland, California); Louis Hong Basel (Berkeley, California); Brent Ridley (Huntington Beach, California); Saul Thomas Griffith (San Francisco, California); James Dylan Mcbride (San Francisco, California); Jeffrey Lamb (San Francisco, California); Eric Preston Lien Suan (Baltimore, Maryland); Erica Lin (Millbrae, California); Joshua Erickson (Oakland, California); Vincent Domenic Romanin (San Francisco, California)
ABSTRACT	An actuator assembly that includes an angled bottom plate having an opposing first side face and second side face; a first set of one or more inflatable actuators engaging the first side face of the angled bottom plate; and a second set of one or more inflatable actuators engaging the second side face of the angled bottom plate. The first and second sets of inflatable actuators are configured to be separately fluidically inflated.
FILED	Friday, March 13, 2020
APPL NO	16/818346
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/10 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/30 (20141201) H02S 20/32 (20141201) Original (OR) Class
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11792933 — Connector interface assembly for enclosed vessels and associated systems and methods

US 11792933	Estrada et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Fermi National Accelerator Laboratory (FNAL) Federally Funded Research and Development Center (FFRDC) Operated by Fermi Research Alliance, LLC (FRA) at Batavia, IL
APPLICANT(S)	Fermi Research Alliance, LLC (Batavia, Illinois)
ASSIGNEE(S)	Fermi Research Alliance, LLC (Batavia, Illinois)
INVENTOR(S)	Juan Estrada (Geneva, Illinois); Guillermo Fernandez Moroni (Batavia, Illinois); Andrew G. Lathrop (Bristol, Illinois); Javier Tiffenberg (Chicago, Illinois)
ABSTRACT	Systems, methods, and apparatus that employ a connector assembly having a substrate layer with an inner aperture and an outer periphery, and one or more signal traces disposed on the substrate that extend from an inner first location to an outer second location of the apparatus, for communicating data between electronic devices positioned within an interior volume of an enclosed vessel and complementary electronic devices positioned in an ambient environment external to the enclosed vessel. An inner connector is conductively connected the signal traces at the inner first location of each signal trace, and an outer connector is conductively connected to the one or more signal traces at the outer second location of each signal trace. A substantially flat exterior surface extends radially over at least a portion of a region between the respective first locations and the respective second locations.
FILED	Thursday, July 29, 2021
APPL NO	17/389306
ART UNIT	2831 — Electrical Circuits and Systems
CURRENT CPC	Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/6215 (20130101) H01R 43/26 (20130101) H01R 43/205 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/18 (20130101) Original (OR) Class H05K 1/0216 (20130101) H05K 3/02 (20130101) H05K 3/282 (20130101) H05K 2201/0715 (20130101) H05K 2201/09063 (20130101) H05K 2201/09227 (20130101) H05K 2201/10189 (20130101) H05K 2201/10507 (20130101)
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National Science Foundation (NSF)

11786170 — Nanomaterial epidermal sensors

US 11786170	Lu et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF)
APPLICANT(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Nanshu Lu (Austin, Texas); Deji Akinwande (Austin, Texas); Shideh Kabiri Ameri Abootorabi (Austin, Texas)
ABSTRACT	Nanomaterial epidermal sensors can be adhered to the skin and worn comfortably and inconspicuously for days to allow for repeated biometric sensing. The nanomaterial epidermal sensors may be comprised of a monolayer of graphene coating a flexible polymer substrate. Various nanomaterial epidermal sensors may be quickly fabricated using a cost-efficient “cut-and-paste” method on transfer paper and can be adhered directly to skin without tape or adhesive, much like a temporary-tattoo. The nanomaterial epidermal sensors may be optically transparent and may be used to measure an electrocardiogram (ECG), an electroencephalogram (EEG) or an electromyogram (EMG) with a signal-to-noise ratio that is comparable to conventional electrodes. In addition, the nanomaterial epidermal sensors may be used to measure other parameters, such as skin temperature or skin hydration.
FILED	Friday, April 28, 2017
APPL NO	16/608994
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/28 (20210101) A61B 5/257 (20210101) A61B 5/291 (20210101) A61B 5/296 (20210101) A61B 5/443 (20130101) Original (OR) Class A61B 5/68335 (20170801) A61B 2562/125 (20130101) A61B 2562/164 (20130101) A61B 2562/222 (20130101) A61B 2562/0285 (20130101)
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11786407 — Dynamic vision enabling visor

US 11786407	Spuck
FUNDED BY	National Science Foundation (NSF) National Radio Astronomy Observatory (NRAO) Federally Funded Research and Development Center (FFRDC) Operated by Associated Universities, Inc. (AUI)at Charlottesville, VA
APPLICANT(S)	Associated Universities, Inc. (Washington, District of Columbia)
ASSIGNEE(S)	Associated Universities, Inc. (Washington, District of Columbia)
INVENTOR(S)	Timothy Steven Spuck (Shippenville, Pennsylvania)
ABSTRACT	Systems of presenting environmental data include a frequency emitting device, a frequency receiving device, wherein the frequency receiving device is tuned to receive a reflected signal from the frequency emitting device, a processor, and a sound emitting device adapted to play a sound transmission. The processor is programmed to compile data from the reflected signal and convert the data from the reflected signal into a sound transmission.
FILED	Tuesday, June 09, 2020
APPL NO	16/896374
ART UNIT	2486 — Recording and Compression
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/08 (20130101) Original (OR) Class Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 2201/165 (20130101) A61H 2201/5048 (20130101) A61H 2201/5064 (20130101)
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11786625 — Air decontamination and self-renewing purification system utilizing a filter

US 11786625	Liu et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Metalmark Innovations, PBC (Cambridge, Massachusetts)
ASSIGNEE(S)	Metalmark Innovations PBC (Cambridge, Massachusetts)
INVENTOR(S)	Sissi Liu (Arlington, Massachusetts); Elijah Shirman (Winchester, Massachusetts); Tanya Shirman (Winchester, Massachusetts)
ABSTRACT	An air purification system includes a conduit extending between an inlet and an outlet, each in fluid communication with an enclosed environment. Ambient air from the enclosed environment enters the conduit via the inlet and treated air exits the conduit and enters the enclosed environment via the outlet. The system further includes a fibrous filter disposed within the conduit and configured to treat the ambient air thereby generating the treated air, and a renewal unit disposed within the conduit and configured to renew the fibrous filter.
FILED	Wednesday, March 30, 2022
APPL NO	17/709069
ART UNIT	1799 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 9/16 (20130101) Original (OR) Class A61L 9/205 (20130101) A61L 2209/12 (20130101) A61L 2209/14 (20130101) A61L 2209/21 (20130101) A61L 2209/22 (20130101) A61L 2209/111 (20130101) Separation B01D 39/1607 (20130101) B01D 39/2041 (20130101) B01D 46/0028 (20130101) B01D 46/0036 (20130101) B01D 46/785 (20220101) B01D 2239/0442 (20130101) B01D 2239/0492 (20130101) B01D 2273/30 (20130101) B01D 2279/50 (20130101) B01D 2279/65 (20130101)
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11786641 — Sheathed embolization device

US 11786641	Maitland et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Human Resource Development (HRD)
APPLICANT(S)	THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas)
ASSIGNEE(S)	The Texas A and M University System (College Station, Texas)
INVENTOR(S)	Duncan J. Maitland (College Station, Texas); Adam M. Orendain (Tulsa, Oklahoma)
ABSTRACT	An embodiment includes an apparatus comprising: a shape memory polymer (SMP) foam having an outside surface; and a membrane that encapsulates at least 50% of the outside surface of the SMP foam; wherein (a) the SMP foam includes a thermoset SMP, and (b) the membrane includes a thermoplastic polymer. Other embodiments are addressed herein.
FILED	Wednesday, October 10, 2018
APPL NO	16/652588
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/12113 (20130101) A61B 17/12118 (20130101) A61B 17/12181 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/07 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) Original (OR) Class A61L 31/18 (20130101) A61L 31/146 (20130101) A61L 31/148 (20130101) A61L 2300/606 (20130101) A61L 2400/16 (20130101) A61L 2430/36 (20130101)
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11786750 — Modulating neural activity in brainstem circuitry with light

US 11786750	Jenkins et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Biomedical Imaging and Bioengineering (NIBIB) NIH Office of the Director (NIHOD) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); VANDERBILT UNIVERSITY (Nashville, Tennessee)
INVENTOR(S)	Michael W. Jenkins (Cleveland, Ohio); Stephen J. Lewis (Cleveland, Ohio); Hillel J. Chiel (Cleveland, Ohio); Eric Duco Jansen (Cleveland, Ohio); Junqi Zhuo (Cleveland, Ohio); Emilie Lothet (Cleveland, Ohio); Gjinovefa Kola (Cleveland, Ohio)
ABSTRACT	The present disclosure relates to modulating neural activity within brainstem circuitry to evoke a certain bodily function (e.g., cardiorespiratory response) in a patient. A controller can configure a light signal (such as an infrared light signal) to deliver an amount of radiant exposure to a specific portion of the brainstem for a time. The specific portion of the brainstem can include brainstem circuitry that is the control center for the certain bodily function. The configured light signal can be delivered to the specific portion of the brainstem by an optrode for the time. During application, the light signal can deliver the amount of radiant exposure to the specific portion of the brainstem to evoke the certain bodily function.
FILED	Friday, November 30, 2018
APPL NO	16/767277
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/067 (20210801) A61N 5/0601 (20130101) A61N 5/0622 (20130101) Original (OR) Class A61N 2005/0626 (20130101) A61N 2005/0659 (20130101)
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11786879 — Three dimensional multiphasic structures via vaporization induced phase separation (VIPS)

US 11786879	Lee et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Daeyeon Lee (Wynnewood, Pennsylvania); Kathleen J Stebe (Penn Valley, Pennsylvania); Tiancheng Wang (Philadelphia, Pennsylvania)
ABSTRACT	This disclosure demonstrates a new method to produce three dimensional multiphasic structures, including bijels, via vapor-induced phase separation (VIPS). In VIPS, the evaporation of the co-solvent from a ternary mixture of oil, water and ethanol, induces phase separation. Particles present in the mixture attach to the interface and arrest the phase separation between water and oil. VIPS enables, inter alia, the fabrication of films and coatings via spreading or spraying particle-laden suspension onto a surface without the need for an outer aqueous phase.
FILED	Tuesday, November 10, 2020
APPL NO	17/093720
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 23/41 (20220101) B01F 23/48 (20220101) B01F 23/806 (20220101) B01F 23/4146 (20220101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0065 (20130101) Original (OR) Class B01J 13/0069 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201)
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11786890 — Photo-redox titanium containing organic frameworks and methods of making and use thereof

US 11786890	Uribe-Romo et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida); FLORIDA STATE UNIVERSITY (Tallahassee, Florida)
ASSIGNEE(S)	FLORIDA STATE UNIVERSITY (Tallahassee, Florida); UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
INVENTOR(S)	Fernando Javier Uribe-Romo (Orlando, Florida); Matthew W. Logan (Orlando, Florida); Kenneth Hanson (Tallahassee, Florida); Suliman Ayad (Tallahassee, Florida)
ABSTRACT	Disclosed herein are metal-organic frameworks and methods of making and use thereof.
FILED	Wednesday, April 04, 2018
APPL NO	16/603039
ART UNIT	1738 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 53/8671 (20130101) B01D 2255/705 (20130101) B01D 2255/802 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1691 (20130101) Original (OR) Class B01J 35/004 (20130101) B01J 35/1019 (20130101) B01J 35/1023 (20130101) B01J 35/1028 (20130101) B01J 35/1038 (20130101) B01J 35/1042 (20130101) B01J 35/1047 (20130101) B01J 2231/625 (20130101) B01J 2531/46 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/28 (20130101)
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11786897 — Inert apparatus for microfluidic motion using magnetic shape memory material

US 11786897	Mullner et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	BOISE STATE UNIVERSITY (Boise, Idaho)
ASSIGNEE(S)	Boise State University (Boise, Idaho)
INVENTOR(S)	Peter Mullner (Boise, Idaho); Geoffrey Brent Johnston (Boise, Idaho); Aaron Smith (Meridian, Idaho); Andrew Armstrong (Boise, Idaho)
ABSTRACT	A magnetic shape memory (MSM) microfluidic device may include a flexible membrane positioned between a channel and an MSM element. The MSM element may engage the flexible membrane to deform the channel at portions of the flexible membrane that are adjacent to non-contracted portions of the MSM element. The flexible membrane may prevent contact between a fluid within the channel and the MSM element. Magnetic field components may be applied to the MSM element and moved along the MSM element enable fluidic flow within the channel while. The device may include an upper portion including the flexible membrane and a lower portion including the MSM element. The upper portion may be interchangeable with additional upper portions.
FILED	Tuesday, February 22, 2022
APPL NO	17/677697
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 3/502707 (20130101) B01L 2200/12 (20130101) B01L 2300/123 (20130101) B01L 2300/0681 (20130101) B01L 2400/043 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201)
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11787691 — Continuous process for the production of nanostructures including nanotubes

US 11787691	Hart et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Design, Manufacture, and Industrial Innovation (DMII)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Anastasios John Hart (Waban, Massachusetts); Brian L. Wardle (Lexington, Massachusetts); Enrique J. Garcia (Saragossa, Spain); Alexander H. Slocum (Bow, New Hampshire)
ABSTRACT	The present invention provides methods for uniform growth of nanostructures such as nanotubes (e.g., carbon nanotubes) on the surface of a substrate, wherein the long axes of the nanostructures may be substantially aligned. The nanostructures may be further processed for use in various applications, such as composite materials. For example, a set of aligned nanostructures may be formed and transferred, either in bulk or to another surface, to another material to enhance the properties of the material. In some cases, the nanostructures may enhance the mechanical properties of a material, for example, providing mechanical reinforcement at an interface between two materials or plies. In some cases, the nanostructures may enhance thermal and/or electronic properties of a material. The present invention also provides systems and methods for growth of nanostructures, including batch processes and continuous processes.
FILED	Tuesday, March 05, 2019
APPL NO	16/292968
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 23/745 (20130101) Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 1/00 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/16 (20170801) C01B 32/18 (20170801) C01B 32/158 (20170801) C01B 32/162 (20170801) C01B 32/164 (20170801) C01B 2202/08 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/127 (20130101) D01F 9/133 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 11/74 (20130101) D06M 23/08 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/582 (20151101) Y02P 20/584 (20151101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/742 (20130101) Y10S 977/843 (20130101)
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11787709 — Gas/liquid plasma reactor with pulsed power supply and secondary direct current electrodes

US 11787709	Locke et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida)
ASSIGNEE(S)	FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida)
INVENTOR(S)	Bruce R. Locke (Tallahassee, Florida); Robert J. Wandell (Tallahassee, Florida); Youneng Tang (Tallahassee, Florida)
ABSTRACT	A method for reacting a liquid phase chemical species includes the steps of providing liquid phase containing at least one liquid phase chemical species, providing a gas phase, and providing a reactor vessel for containing the liquid phase and the gas phase. The liquid phase and the gas phase are placed in the reactor vessel so as to form a liquid-gas interface between the liquid phase and the gas phase within the reactor vessel. A pulsed discharge cathode and anode are provided for creating a pulsed discharge electric field at the liquid-gas interface. A pulsed power input to the pulsed discharge cathode and anode is provided, thereby creating a plasma comprising ions at the liquid-gas interface. A secondary electric field is directed transverse to the liquid-gas interface, wherein the secondary electric field will drive ions from the gas phase into the liquid phase to react with the liquid phase species.
FILED	Thursday, March 25, 2021
APPL NO	17/212244
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/70 (20130101) C02F 1/4608 (20130101) Original (OR) Class C02F 2101/36 (20130101) C02F 2103/06 (20130101) C02F 2201/46 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/48 (20130101)
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11787770 — Methods of coupling a carbon containing moiety to an amine containing moiety

US 11787770	Cooks et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Robert Graham Cooks (West Lafayette, Indiana); Pallab Basuri (Chennai, India); Nicolás M. Morato (West Lafayette, Indiana); Thalappil Pradeep (Madras, India)
ABSTRACT	The invention generally relates to methods of coupling a carbon containing moiety to an amine containing moiety.
FILED	Tuesday, May 18, 2021
APPL NO	17/323290
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 235/08 (20130101) Original (OR) Class
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11788002 — Fluorescent conjugated polymers containing semi-ladder units for light-emitting field-effect transistors

US 11788002	Yu et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	University of Chicago (Chicago, Illinois)
ASSIGNEE(S)	THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
INVENTOR(S)	Luping Yu (Chicago, Illinois); Mohammad A. Awais (Chicago, Illinois); Valerii Sharapov (Chicago, Illinois); Dafei Yuan (Chicago, Illinois)
ABSTRACT	Materials are provided for use as active emissive layers in organic electronic devices such as light-emitting filed effect transistors. Light-emitting transistors (LET) are an alternative to light-emitting diodes and have several important benefits, however, materials developed specifically for LET are quite scarce. Herein a new family of materials is disclosed that has been developed specifically for LET.
FILED	Friday, November 13, 2020
APPL NO	17/097731
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/07 (20130101) Original (OR) Class C09K 2211/104 (20130101) C09K 2211/1011 (20130101) Organic electric solid-state devices H10K 50/16 (20230201) H10K 50/171 (20230201) H10K 85/615 (20230201) H10K 85/6572 (20230201)
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11788006 — Violet light exciteable blue-emitting oxynitride phosphors and uses thereof

US 11788006	Brgoch et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	University of Houston System (Houston, Texas)
ASSIGNEE(S)	University of Houston System (Houston, Texas)
INVENTOR(S)	Jakoah Brgoch (Houston, Texas); Shruti Hariyani (Houston, Texas)
ABSTRACT	Provided herein are phosphors of the general molecular formula: A_3-2xEu_xMP₃O₉N, wherein the variables are as defined herein. Methods of producing the phosphors are also provided. In some aspects, the present disclosure provides light-emitting devices comprising these phosphors.
FILED	Wednesday, August 24, 2022
APPL NO	17/821907
ART UNIT	2875 — Optics
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7728 (20130101) C09K 11/7731 (20130101) Original (OR) Class C09K 11/7787 (20130101) C09K 11/7789 (20130101) C09K 11/77346 (20210101)
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11788100 — Gene for induction of parthenogenesis, a component of apomictic reproduction

US 11788100	Ozias-Akins et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI)
APPLICANT(S)	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia)
ASSIGNEE(S)	University of Georgia Research Foundation, Inc. (Athens, Georgia)
INVENTOR(S)	Peggy Ozias-Akins (Tifton, Georgia); Joann A. Conner (Tifton, Georgia)
ABSTRACT	Methods and compositions disclosed herein generally relate to genes involved in plant reproduction and methods of using the same.
FILED	Tuesday, March 17, 2020
APPL NO	16/821755
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8287 (20130101) Original (OR) Class
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11788111 — Compositions and methods for making selenocysteine containing polypeptides

US 11788111	Soll et al.
FUNDED BY	Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	YALE UNIVERSITY (New Haven, Connecticut)
INVENTOR(S)	Dieter Soll (Guilford, Connecticut); Takahito Mukai (New Haven, Connecticut); Kyle Hoffman (New Haven, Connecticut)
ABSTRACT	Non-naturally occurring tRNA^Secand methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring tRNA^Seccan be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the requirement of an SECIS element. In some embodiments, selenocysteine containing polypeptides are manufactured by co-expressing a non-naturally occurring tRNA^Seca recombinant expression system, such as E. coli, with SerRS, EF-Tu, SelA, or PSTK and SepSecS, and an mRNA with at least one codon that recognizes the anticodon of the non-naturally occurring tRNA^Sec.
FILED	Thursday, October 04, 2018
APPL NO	16/754130
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 209/01001 (20130101)
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11788156 — Compositions comprising riboregulators and methods of use thereof

US 11788156	Green et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Defense Threat Reduction Agency (DTRA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts)
INVENTOR(S)	Alexander A. Green (Chestnut Hill, Massachusetts); Peng Yin (Cambridge, Massachusetts); James J. Collins (Newton, Massachusetts); Jongmin Kim (Cambridge, Massachusetts)
ABSTRACT	The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.
FILED	Thursday, September 16, 2021
APPL NO	17/477456
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1138 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Original (OR) Class
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11788394 — Systems and methods for deployment of electric-based fracturing tools in vertical wells

US 11788394	Mehrvand et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Eden GeoPower, Inc. (Somerville, Massachusetts)
ASSIGNEE(S)	Eden GeoPower, Inc. (Somerville, Massachusetts)
INVENTOR(S)	Mehrdad Mehrvand (Somerville, Massachusetts); Ammar Alali (Somerville, Massachusetts)
ABSTRACT	Systems and methods for deployment of electric-based fracturing tools in vertical wells are disclosed. A method of electric-based fracturing may include lowering an electrical stimulation tool into a wellbore using a drill pipe and isolating a lower portion of the wellbore that is downhole from an upper portion of the wellbore. The electrical stimulation tool may be disposed in the lower portion of the wellbore. A system for electric-based fracturing may include an isolation mechanism and an electrical stimulation tool. The isolation mechanism may be configured to expand from a retracted configuration spaced from an interior surface of a wellbore to an expanded configuration in contact with the inner surface of the wellbore. The electrical stimulation tool may be operatively coupled with the isolation mechanism and may be configured to be disposed distally relative to the isolation mechanism when positioned in the wellbore.
FILED	Thursday, July 15, 2021
APPL NO	17/376842
ART UNIT	3674 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 33/16 (20130101) E21B 43/26 (20130101) Original (OR) Class E21B 43/2401 (20130101)
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11788916 — Distributed sensor networks deployed using soft growing robots

US 11788916	Gruebele et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford JuniorUniversity (Stanford, California)
INVENTOR(S)	Alexander M. Gruebele (Stanford, California); Andrew C. Zerbe (Woodside, California); Margaret M. Coad (Stanford, California); Mark R. Cutkosky (Palo Alto, California)
ABSTRACT	A distributed sensor network for soft growing robots is provided. Sensor bands are distributed at discrete intervals along the length of the flexible tube, and the sensor bands each are wrapped circumferentially around the diameter of the flexible tube. Each sensor band has one or more sensors and one or more semi-rigid islands containing a self-contained microcontroller, and one or more communication lines to an aggregator microcontroller located at the base of the soft growing robot communicatively connecting signals from the sensor bands. A casing laminates the distributed sensor network. In one example the encasing has cavities or a tooth geometry to allow bending. The casing is flexible to not hinder the growth of the soft growing robot, yet protecting the distributed sensor network.
FILED	Friday, December 10, 2021
APPL NO	17/548130
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Manipulators; Chambers Provided With Manipulation Devices B25J 9/14 (20130101) B25J 9/142 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/04 (20130101) Original (OR) Class
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11789453 — Apparatus and method for agricultural data collection and agricultural operations

US 11789453	Chowdhary et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E) National Science Foundation (NSF) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Girish Chowdhary (Champaign, Illinois); Chinmay P. Soman (Urbana, Illinois); Erkan Kayacan (Champaign, Illinois); Benjamin C. Thompson (Champaign, Illinois); Zhongzhong Zhang (Urbana, Illinois); Anwesa Choudhuri (West Bengal, India)
ABSTRACT	Aspects of the subject disclosure may include, for example, obtaining video data from a single monocular camera, wherein the video data comprises a plurality of frames, wherein the camera is attached to a mobile robot that is travelling along a lane defined by a row of crops, wherein the row of crops comprises a first plant stem, and wherein the plurality of frames include a depiction of the first plant stem; obtaining robot velocity data from encoder(s), wherein the encoder(s) are attached to the robot; performing foreground extraction on each of the plurality of frames of the video data, wherein the foreground extraction results in a plurality of foreground images; and determining, based upon the plurality of foreground images and based upon the robot velocity data, an estimated width of the first plant stem. Additional embodiments are disclosed.
FILED	Friday, August 24, 2018
APPL NO	16/641618
ART UNIT	2645 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Systems for Controlling or Regulating Non-electric Variables G05D 1/0246 (20130101) Original (OR) Class Electric Digital Data Processing G06F 18/2155 (20230101) Computer Systems Based on Specific Computational Models G06N 20/10 (20190101) Image or Video Recognition or Understanding G06V 20/41 (20220101) G06V 20/188 (20220101) Wireless Communication Networks H04W 4/40 (20180201)
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11790144 — Fast, efficient real-time electro-magnetic systems simulator that dynamically accepts user input

US 11790144	Colleran et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Elloveo, Inc. (Los Angeles, California)
ASSIGNEE(S)	Elloveo, Inc. (Los Angeles, California)
INVENTOR(S)	David M. Colleran (Altadena, California); Carlos Manuel Godino Fernandez (Pasadena, California)
ABSTRACT	A method is described. The method includes calculating electric and/or magnetic fields in free space in response to: i) respective positions and motions of one or more charges and/or one or more current loops in the free space; ii) charges on nodes in the electrical circuit in the free space; iii) charge motions in the electrical circuit. The method includes calculating new respective positions and motions of the one or more charges and/or one or more current loops in the free space in response to respective forces applied to the one or more charges and/or the one or more current loops by the electric and/or magnetic fields. The method includes calculating new charges on nodes within the electrical circuit and new charge motions within the electrical circuit in response to the new positions and motions of the one or more charges and/or one or more current loops in free space, the charges on the nodes in the electrical circuit and the charge motions in the electrical circuit. The method includes concurrently rendering on a display of the computing system respective images of the one or more charges and/or one or more current loops according to the new respective positions and motions and the new charge motions within the electrical circuit. The method includes repeating the above to fluidly render on the display respective inter-active behaviors of the one or more charges and/or the one or more magnetic current loop in the free space and the charge motions in the electrical circuit.
FILED	Saturday, October 13, 2018
APPL NO	16/159660
ART UNIT	2198 — Printing/Measuring and Testing
CURRENT CPC	Electric Digital Data Processing G06F 3/0482 (20130101) G06F 30/367 (20200101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/20 (20130101)
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11790261 — Tunable coupling between a readout cavity and a parametric amplifier to enhance qubit measurements

US 11790261	Rosenthal et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Multidisciplinary University Research Initiative (MURI) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado); Universitat Innsbruck (Innsbruck, Austria)
ASSIGNEE(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado); Universitat Innsbruck (Innsbruck, Austria)
INVENTOR(S)	Eric Rosenthal (Boulder, Colorado); Konrad Lehnert (Boulder, Colorado); Christian Schneider (Innsbruck, Austria)
ABSTRACT	Technology is disclosed herein that the enhances the measurability and scalability of qubits in a quantum computing environment. In an implementation, a superconducting amplifier device comprises a parametric amplifier and a tunable coupling between the parametric amplifier and a readout cavity external to the superconducting amplifier device. The tunable coupling allows an entangled signal, associated with a qubit in the readout cavity, to transfer from the readout cavity to the parametric amplifier. The parametric amplifier amplifies the entangled signal to produce an amplified signal as output to a measurement sub-system.
FILED	Thursday, March 04, 2021
APPL NO	17/192479
ART UNIT	2851 — Printing/Measuring and Testing
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class Amplifiers H03F 19/00 (20130101)
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11791075 — Iron-based superconducting permanent magnet and method of manufacture

US 11791075	Weiss et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	The Florida State University Research Foundation, Inc. (Tallahassee, Florida); Japan Science and Technology Agency (Saitama, Japan)
ASSIGNEE(S)	The Florida State University Research Foundation, Inc. (Tallahassee, Florida); Japan Science and Technology Agency (Saitama, Japan)
INVENTOR(S)	Jeremy Weiss (Tallahassee, Florida); Akiyasu Yamamoto (Tokyo, Japan); Eric Hellstrom (Tallahassee, Florida)
ABSTRACT	The present invention provides for polycrystalline superconducting permanent magnets which are synthesized of doped superconducting (AE) Fe₂As₂compounds, where AE denotes an alkaline earth metal, such as Ba, Sr, Mg or Ca. The superconducting permanent magnets of the present invention can be magnetized in their superconducting state by induced currents, resulting in trapped magnetization that scales with the size of the bulk material. The magnitude of the trapped field has been demonstrated to be over 1 T and is predicted to be over 10 T if the technology is scaled, which is much higher than the capabilities of permanent magnets and other superconducting polycrystalline bulks currently known in the art.
FILED	Thursday, August 15, 2019
APPL NO	16/541377
ART UNIT	1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/08 (20130101) Original (OR) Class H01F 6/00 (20130101) H01F 13/003 (20130101) H01F 41/0253 (20130101) Electric solid-state devices not otherwise provided for H10N 60/855 (20230201)
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11791146 — Multiplex charge detection mass spectrometry

US 11791146	Williams et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Evan R. Williams (Oakland, California); Conner C. Harper (Albany, California); Andrew G. Elliott (Berkeley, California)
ABSTRACT	Systems and multiplexing methods for measuring the mass of multiple large molecules simultaneously using multiple ion trapping with charge detection mass spectrometry (CDMS) are described. The methods trap ions with a broad range of energies that decouple ion frequency and m/z measurements allowing energy measurements of each ion throughout the acquisition. The ion energy may be obtained from the ratio of the intensity of the fundamental to the second harmonic frequencies of the periodic trapping oscillation making it possible to measure both the m/z and charge of each ion. Because ions with the exact same m/z but different energies appear at different frequencies, the probability of ion-ion interference is significantly reduced. By maximizing the decoupling of ion m/z from frequency, the rate of signal overlap is significantly reduced making it possible to trap more ions and substantially reduce analysis time.
FILED	Thursday, September 02, 2021
APPL NO	17/465045
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/025 (20130101) Original (OR) Class H01J 49/0031 (20130101) H01J 49/0036 (20130101) H01J 49/4245 (20130101)
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11791478 — Reduced-temperature sintering of spinel-type coatings and layers with metallic alloy powder precursors

US 11791478	Zhu et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Tennessee Technological University (Cookeville, Tennessee)
ASSIGNEE(S)	Tennessee Technological University (Cookeville, Tennessee)
INVENTOR(S)	Jiahong Zhu (Cookeville, Tennessee); Yutian Yu (Cookeville, Tennessee); Brian Bates (Cookeville, Tennessee)
ABSTRACT	A method of forming a spinel coating on a substrate is disclosed including the steps of coating at least a portion of the substrate with a precursor including an alloy powder, and sintering the precursor at a temperature of less than 1000 degrees Celsius to form the spinel coating. The alloy powder used for the precursor can include particles having a particle size of less than 10 micrometers. The method can be utilized to form spinel coatings as contact surfaces between electrodes and interconnects of solid oxide fuel cell (SOFC) stacks.
FILED	Wednesday, October 07, 2020
APPL NO	17/065158
ART UNIT	1738 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/10 (20220101) B22F 1/054 (20220101) B22F 3/10 (20130101) B22F 3/24 (20130101) B22F 2003/242 (20130101) B22F 2201/03 (20130101) B22F 2301/15 (20130101) B22F 2301/35 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0236 (20130101) Original (OR) Class H01M 8/0245 (20130101) H01M 8/2432 (20160201) H01M 2008/1293 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101)
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11791555 — Nonreciprocal and reconfigurable phased-array antennas

US 11791555	Gómez-Diaz et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Juan Sebastián Gómez-Diaz (Davis, California); Alejandro Álvarez-Melcón (Cartagena, Spain); Jiawei Zang (Beijing, China PRC)
ABSTRACT	A nonreciprocal phased-array antenna includes an array of resonant antennas a₁, . . . , a_n. During transmission, an outbound signal having a frequency f₀and a phase shift φ_dicaused by propagation through a data network feeds into each resonant antenna a_i. Each resonant antenna a_iupconverts the outbound signal using a modulation signal having a frequency f_mand a phase shift φ_micaused by propagation through a modulation network to produce an upconverted radiated signal having a frequency f₀+f_mand a phase proportionate to φ_di+φ_mi. During reception, an inbound signal of frequency f₀+f_mis received at each resonant antenna a_iand is downconverted using the modulation signal to produce a downconverted signal having a frequency f₀and a phase proportionate to −φ_mi. After passing through the data network to the inbound port, the downconverted signal has a phase proportionate to φ_di−φ_mi.
FILED	Wednesday, November 23, 2022
APPL NO	17/993249
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 3/36 (20130101) Original (OR) Class
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11791566 — Extremely electrically small antennas based on multiferroic materials

US 11791566	Sepulveda et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Abdon E. Sepulveda (Los Angeles, California); Gregory P. Carman (Los Angeles, California); Jinzhao Hu (Los Angeles, California); Joseph Devin Schneider (Los Angeles, California); Elmer Wu (Rowland Heights, California); Zhi Yao (Los Angeles, California); Sidhant Tiwari (Riverside, California); Wenzhong Yan (Los Angeles, California)
ABSTRACT	A multiferroic antenna apparatus and method are described which provides increased energy efficiencies and ease of implementation. Magnetoelastic and/or magnetostrictive resonator are coupled to a piezoelectric substrate, along with electrodes coupled to its opposing surfaces. In receive mode the resonators create mechanical waves in response to being excited into magnetic oscillation by receiving electromagnetic radiation, and these mechanical waves coupled to the piezoelectric substrate causing it to generate an electrical output signal at said electrodes. In transmit mode an electrical signal coupled through the electrodes induces mechanical waves in the piezoelectric substrate directed to the resonators which are excited into magnetic oscillation to output electromagnetic waves.
FILED	Thursday, February 04, 2021
APPL NO	17/168048
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 3/44 (20130101) H01Q 21/067 (20130101) Original (OR) Class
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11791854 — Circuits for intermediate-frequency-filterless, double-conversion receivers

US 11791854	Han et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Guoxiang Han (San Jose, California); Peter R. Kinget (Summit, New Jersey); Tanbir Haque (Jackson Heights, New York)
ABSTRACT	Circuits for receivers including: N first mixers that each receive an input signal, are each clocked by a different phase of a first common clock frequency, and each provide an output; and for each N first mixer: a set of M second mixers, wherein each second mixer receives as an input the output of a same one of the N first mixers unique to the set, wherein each of M second mixer is clocked by a different phase of a second common clock frequency, and wherein each second mixer has an output; a set of M resistors having a first side and a second side, wherein the first side is connected to the output of a corresponding one of the set of M second mixers; and a set of M trans-impedance amplifiers that each having an input connected to the second side of a corresponding one of the resistors.
FILED	Thursday, December 23, 2021
APPL NO	17/561622
ART UNIT	2645 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Transmission H04B 1/12 (20130101) H04B 1/16 (20130101) Original (OR) Class
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11792061 — Estimating frequency-offsets and multi-antenna channels in MIMO OFDM systems

US 11792061	Giannakis et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (, None)
INVENTOR(S)	Georgios B. Giannakis (Minnetonka, Minnesota); Xiaoli Ma (Auburn, Alabama)
ABSTRACT	Techniques are described for carrier frequency offset (CFO) and channel estimation of orthogonal frequency division multiplexing (OFDM) transmissions over multiple-input multiple-output (MIMO) frequency-selective fading channels. A wireless transmitter forms blocks of symbols by inserting training symbols within two or more blocks of information-bearing symbols. The transmitter applies a hopping code to each of the blocks of symbols to insert a null subcarrier at a different position within each of the blocks of symbols, and a modulator outputs a wireless signal in accordance with the blocks of symbols. A receiver receives the wireless signal and estimates the CFO, and outputs a stream of estimated symbols based on the estimated CFO.
FILED	Wednesday, April 06, 2022
APPL NO	17/714926
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 7/046 (20130101) H04B 7/063 (20130101) H04B 7/066 (20130101) H04B 7/0413 (20130101) Multiplex Communication H04J 11/0063 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0016 (20130101) H04L 25/0202 (20130101) H04L 25/0204 (20130101) H04L 25/0228 (20130101) H04L 25/0242 (20130101) H04L 27/2607 (20130101) H04L 27/2613 (20130101) H04L 27/2626 (20130101) Original (OR) Class H04L 27/2657 (20130101) H04L 27/2671 (20130101) H04L 27/2672 (20130101) H04L 27/2675 (20130101) H04L 27/2692 (20130101) H04L 27/2695 (20130101) H04L 27/26134 (20210101)
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11793086 — Magnetic tunneling junctions with a magnetic barrier

US 11793086	Wang et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona)
INVENTOR(S)	Weigang Wang (Tucson, Arizona); Ty A. Newhouse-Illige (Tucson, Arizona); Shufeng Zhang (Tucson, Arizona); Yihong Cheng (Tucson, Arizona); Meng Xu (Tucson, Arizona); Pravin Khanal (Tucson, Arizona)
ABSTRACT	Advanced magnetic tunneling junctions (MTJs) that dramatically reduce power consumption (switching energy, ESw) while maintaining a reasonably high tunneling magnetoresistance (on/off ratio, TMR) and strong thermal stability at room temperature are described herein. The MTJs include a magnetic insulator, such as an antiferromagnetic material, as the tunnel barrier. A more energy efficient switching in the MTJs is achieved by exchange bias switching (EB) due to the magnetoelectric effect (ME) or by magnon assisted switching.
FILED	Monday, May 06, 2019
APPL NO	17/051680
ART UNIT	2811 — Semiconductors/Memory
CURRENT CPC	Electronic Memory Devices H10B 61/00 (20230201) Electric solid-state devices not otherwise provided for H10N 50/80 (20230201) Original (OR) Class H10N 50/85 (20230201)
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Department of Agriculture (USDA)

11788052 — Method for treatment and control of plant disease

US 11788052	Gonzalez et al.
FUNDED BY	Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS)
APPLICANT(S)	The Texas A and M University System (College Station, Texas)
ASSIGNEE(S)	The Texas A and M University System (College Station, Texas)
INVENTOR(S)	Carlos F. Gonzalez (College Station, Texas); Stephen J. Ahern (College Station, Texas); Mayukh Das (College Station, Texas); Ryland F. Young, III (College Station, Texas); Tushar Suvra Bhowmick (College Station, Texas)
ABSTRACT	Methods and compositions are provided for preventing or reducing symptoms or disease associated with Xylella fastidiosa or Xanthomonas axonopodis in a plant. The invention provides novel bacteriophages virulent to Xylella fastidiosa or Xanthomonas axonopodis, including XfaMija and XfaMijo, and further provides methods for treating or preventing Pierce's Disease or Citrus Canker in plants.
FILED	Tuesday, December 03, 2019
APPL NO	16/702154
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/40 (20200101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/00 (20130101) Original (OR) Class C12N 7/00 (20130101) C12N 15/8281 (20130101) C12N 2795/10121 (20130101) C12N 2795/10131 (20130101) C12N 2795/10221 (20130101) C12N 2795/10231 (20130101) C12N 2795/10321 (20130101) C12N 2795/10331 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/91 (20210501)
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11788100 — Gene for induction of parthenogenesis, a component of apomictic reproduction

US 11788100	Ozias-Akins et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI)
APPLICANT(S)	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia)
ASSIGNEE(S)	University of Georgia Research Foundation, Inc. (Athens, Georgia)
INVENTOR(S)	Peggy Ozias-Akins (Tifton, Georgia); Joann A. Conner (Tifton, Georgia)
ABSTRACT	Methods and compositions disclosed herein generally relate to genes involved in plant reproduction and methods of using the same.
FILED	Tuesday, March 17, 2020
APPL NO	16/821755
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8287 (20130101) Original (OR) Class
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11788891 — Method and system for active line scan imaging

US 11788891	Kim et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S)	Moon S. Kim (Ashton, Maryland); Diane E. Chan (Odenton, Maryland); Jianwei Qin (Ellicott City, Maryland); Insuck Baek (Burtonsville, Maryland)
ABSTRACT	A line scan imaging system scans a targeted inspection area and gathers reflectance and fluorescence data. The inspection system comprises at least a rotatable/pivotable mirror-faced triangular prism, a line illumination source, and a line scan hyperspectral camera. The prism has a mirrored camera face and a mirrored illumination face. In operation, as the prism rotates, the camera instantaneous field of view (IFOV) and the projected illumination line converge at a nadir convergence scan line so that the hyperspectral camera receives line scan data from the nadir convergence scan line as the nadir convergence scan line traverses an inspection area.
FILED	Thursday, June 09, 2022
APPL NO	17/836310
ART UNIT	2877 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/021 (20130101) G01J 3/024 (20130101) G01J 3/0237 (20130101) G01J 3/2823 (20130101) Original (OR) Class
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11789018 — Rapid concentration, recovery and detection of pathogens in food samples

US 11789018	Ladisch et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Michael Ralph Ladisch (West Lafayette, Indiana); Eduardo de Aquino Ximenes (West Lafayette, Indiana); Seockmo Ku (West Lafayette, Indiana); Kirk Solon Foster (West Lafayette, Indiana); Thomas Richard Kreke (West Lafayette, Indiana); Xingya (Linda) Liu (West Lafayette, Indiana); James Thomas Jones (Brookston, Indiana); Amanda Deering (West Lafayette, Indiana); Jaycey Hardenstein (West Lafayette, Indiana); Alisha Tungare (West Lafayette, Indiana)
ABSTRACT	Methods for rapidly concentrating a food sample for efficient detection of bacteria are disclosed. A microfiltration approach followed by centrifugation was used to concentrate the cells with an enzyme (e.g., a protease) added at the beginning of the process to facilitate more efficient micro-filtering. The enzyme was found to have no significant effect on cell viability.
FILED	Friday, July 22, 2016
APPL NO	15/735273
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4005 (20130101) G01N 1/4044 (20130101) G01N 33/56916 (20130101) Original (OR) Class G01N 2001/2866 (20130101) G01N 2001/4088 (20130101) G01N 2333/245 (20130101) G01N 2333/255 (20130101)
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National Aeronautics and Space Administration (NASA)

11787752 — High density hybrid rocket motor

US 11787752	Sherman et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	TERVES, LLC (Euclid, Ohio)
ASSIGNEE(S)	TERVES, LLC (Euclid, Ohio)
INVENTOR(S)	Andrew J. Sherman (Mentor, Ohio); Brian Werry (Euclid, Ohio); Andrew Cortopassi (Euclid, Ohio); Eric Boyer (Euclid, Ohio)
ABSTRACT	A high density, generally recognized as safe, hybrid rocket motor is described, having a density-specific impulse similar to a solid rocket motor, with good performance approaching or equal to a liquid rocket motor. These high density hybrid motors resolve the packaging efficiency/effectiveness problems limiting the application of safe, low cost hybrid motor technology.
FILED	Monday, March 22, 2021
APPL NO	17/208467
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 23/001 (20130101) C06B 23/006 (20130101) C06B 31/28 (20130101) Original (OR) Class Detonating or Priming Devices; Fuses; Chemical Lighters; Pyrophoric Compositions C06C 9/00 (20130101) Means for Generating Smoke or Mist; Gas-attack Compositions; Generation of Gas for Blasting or Propulsion C06D 5/10 (20130101) Jet-propulsion Plants F02K 9/24 (20130101) F02K 9/26 (20130101) F02K 9/70 (20130101) F02K 9/72 (20130101) F02K 9/425 (20130101)
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11790170 — Converting unstructured technical reports to structured technical reports using machine learning

US 11790170	Mishra et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	Chevron U.S.A. Inc. (San Ramon, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CHEVRON U.S.A. INC. (San Ramon, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Asitang Mishra (Los Angeles, California); Shuxing Cheng (Houston, Texas); Annie Didier (Pasadena, California); Chris Mattmann (Pasadena, California); Hamsa Shwetha Venkataram (Pasadena, California); Grant Lee (Houston, Texas); Wayne Moses Burke (Ann Arbor, Michigan); Vishal Lall (Los Angeles, California)
ABSTRACT	A computer-implemented, machine learning-based method of converting an unstructured technical report into a structured technical report includes obtaining an unstructured technical report, tokenizing the unstructured technical report into an n-gram array, identifying and filtering non-interesting n-grams from the first n-gram array based on common language usage of the non-interesting n-grams and a determination that the non-interesting n-grams do not appear on a confirmed technical entity database, generating and displaying a technical entity candidate list from the filtered n-gram array, displaying, obtaining, from a pattern matching model and/or a graphical user interface, an indication that a technical entity candidate is a technical entity of interest, appending the technical entity of interest to the confirmed technical entity database, generating and displaying a structured technical report with the confirmed technical entities and corresponding technical entity value parameters, and iterating the process to refine the pattern matching model.
FILED	Friday, January 10, 2020
APPL NO	16/740066
ART UNIT	2656 — Digital Audio Data Processing
CURRENT CPC	Electric Digital Data Processing G06F 40/30 (20200101) G06F 40/205 (20200101) G06F 40/284 (20200101) G06F 40/295 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101)
VIEW PATENT	@ USPTO: Full Text PDF

11793076 — Ion-enhanced thermoelectric generator

US 11793076	Howe et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Natick Soldier Systems Center (NSSC) National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	HOWE INDUSTRIES LLC (Scottsdale, Arizona)
ASSIGNEE(S)	HOWE INDUSTRIES LLC (Scottsdale, Arizona)
INVENTOR(S)	Troy Michael Howe (Tempe, Arizona); Steven Daniel Howe (Mesa, Arizona)
ABSTRACT	A thermoelectric converter including a thermoelectric generator and a radiation source. The thermoelectric generator includes a hot source, a cold source, n-type material, and p-type material. The radiation source emits ionizing radiation that increases electrical conductivity. Also detailed is a method of using radiation to reach high efficiency with a thermoelectric converter that includes providing a thermoelectric generator and a radiation source, with the thermoelectric generator including a hot source, a cold source, n-type material, and p-type material, and emitting ionizing radiation with the radiation source to increase the electrical conductivity which strips electrons in the n-type material, the p-type material, or both the n-type material and p-type material from their nuclei with the electrons then free to move within the material.
FILED	Wednesday, March 10, 2021
APPL NO	17/198040
ART UNIT	1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Electric solid-state devices not otherwise provided for H10N 10/13 (20230201) Original (OR) Class H10N 10/17 (20230201) H10N 10/855 (20230201)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Veterans Affairs (DVA)

11786540 — Gliflozins and a method for their delivery during resuscitation from cardiac arrest to improve survival outcomes

US 11786540	Gazmuri et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	Rosalind Franklin University of Medicine and Science (North Chicago, Illinois); The United States as Represented by The Department of Veterans Affairs (Washington, D.C.) (Washington, District of Columbia)
ASSIGNEE(S)	Rosalind Franklin University of Medicine and Science (North Chicago, Illinois); The United States as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Raúl J. Gazmuri (Chicago, Illinois); Jeejabai Radhakrishnan (Gurnee, Illinois); Salvatore Aiello (Inverness, Illinois)
ABSTRACT	A method of performing cardiopulmonary resuscitation on a mammalian subject including the step of delivering an effective amount of a gliflozin solution during cardiac resuscitation through an intravenous or intraosseous route.
FILED	Friday, July 09, 2021
APPL NO	17/371427
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7048 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

11787840 — Compositions and methods for treating and preventing autoimmune induced cardiac long QT syndrome

US 11787840	Boutjdir et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	The United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)	THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); NEW YORK UNIVERSITY (New York, New York)
INVENTOR(S)	Mohamed Boutjdir (Brooklyn, New York); Timothy Jude Cardozo (New York, New York)
ABSTRACT	Disclosed herein, are decoy peptides or polypeptides capable of neutralizing and/or inhibiting the binding of anti-Ro antibodies to a hERG potassium channel extracellular pore region, and pharmaceutical compositions containing the decoy peptides or polypeptides and methods of use.
FILED	Friday, August 21, 2020
APPL NO	17/637614
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Peptides C07K 14/00 (20130101) Original (OR) Class C07K 16/18 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

United States Postal Service (USPS)

11790195 — System and method for reading a barcode independently of image resolution or scale

US 11790195	Simpson
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	Ryan J. Simpson (Vienna, Virginia)
ABSTRACT	The present disclosure relates to a system for reading a barcode independently of image resolution or scale of a captured barcode image. In one embodiment, the system includes an optical sensor and a processor. The optical scanner can scan a barcode, including a plurality of bars and spaces, into a scanned image. The processor can convert the scanned image into binary data. The processor can also calculate numbers of ones (1s) between zeros (0s) in the binary data and determine widths of one of i) each of the bars and ii) each of the spaces based on the calculated numbers of ones (1s). The processor can further calculate numbers of zeros (0s) between ones (1s) in the binary data and determine widths of the other one of i) each of the bars and ii) each of the spaces based on the calculated numbers of zeros (0s).
FILED	Wednesday, July 27, 2022
APPL NO	17/815533
ART UNIT	2876 — Optics
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/10722 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

11790471 — System and method of providing identity verification services

US 11790471	Punnoose et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	Josen Punnoose (Crofton, Maryland); Sachin Agarwal (Washington, District of Columbia)
ABSTRACT	Generating authentication credentials includes receiving from a first user input identifying a customer identifier for an online account with a business or organization and a residential or business physical address, and sending via a network a notification to a first user system to follow instructions on a mail piece to be received by the first user. The mail piece is physically sent via a distribution network to the physical address and an online application is activated in response to scanning a coded indicia on the mail piece. Data indicative of an identity of the first user is received and the identity of the first user is verified based on at least information associated with the coded indicia and the received data. A recommendation is generated whether to approve the online account and an electronic credential is created for the first user based on acceptance of the online account.
FILED	Thursday, September 03, 2020
APPL NO	17/011859
ART UNIT	2683 — Telemetry and Code Generation Vehicles and System Alarms
CURRENT CPC	Electric Digital Data Processing G06F 21/31 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 30/413 (20220101) Wireless Communication Networks H04W 4/029 (20180201)
VIEW PATENT	@ USPTO: Full Text PDF

Department of the Interior (DOI)

11790213 — Identifying complex events from hierarchical representation of data set features

US 11790213	Yao et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Prostate Cancer Research Program (USAMRMCPCRP) Department of the Interior (DOI) Interior Business Center (IBC)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)	SRI INTERNATIONAL (Menlo Park, California)
INVENTOR(S)	Yi Yao (Princeton, New Jersey); Ajay Divakaran (Monmouth Junction, New Jersey); Pallabi Ghosh (College Park, Maryland)
ABSTRACT	Techniques are disclosed for identifying multimodal subevents within an event having spatially-related and temporally-related features. In one example, a system receives a Spatio-Temporal Graph (STG) comprising (1) a plurality of nodes, each node having a feature descriptor that describes a feature present in the event, (2) a plurality of spatial edges, each spatial edge describing a spatial relationship between two of the plurality of nodes, and (3) a plurality of temporal edges, each temporal edge describing a temporal relationship between two of the plurality of nodes. Furthermore, the STG comprises at least one of: (1) variable-length descriptors for the feature descriptors or (2) temporal edges that span multiple time steps for the event. A machine learning system processes the STG to identify the multimodal subevents for the event. In some examples, the machine learning system comprises stacked Spatio-Temporal Graph Convolutional Networks (STGCNs), each comprising a plurality of STGCN layers.
FILED	Wednesday, June 12, 2019
APPL NO	16/439508
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/045 (20230101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Environmental Protection Agency (EPA)

11787706 — Filter assembly for disinfecting pathogens using multiple wavelength ultraviolet light emitting diodes (UV-LEDs) and method therefor

US 11787706	Ryu et al.
FUNDED BY	Environmental Protection Agency (EPA)
APPLICANT(S)	U.S. Environmental Protection Agency (Washington, District of Columbia)
ASSIGNEE(S)	U.S. Environmental Protection Agency (Washington, District of Columbia)
INVENTOR(S)	Hodon Ryu (Cincinnati, Ohio); Hyoungmin Woo (Cincinnati, Ohio)
ABSTRACT	A point-of-use (POU) water filtration device has a container. A plurality of channels is formed within the container, water entering the container flowing through the plurality of channels. A plurality of Ultraviolet (UV) Light Emitting Diodes (LEDs) is provided. Each of the plurality of UV LEDs illuminating UV light down an associated channel of the plurality of channels.
FILED	Tuesday, July 27, 2021
APPL NO	17/386228
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/10 (20130101) A61L 2/26 (20130101) A61L 2/088 (20130101) A61L 2202/11 (20130101) A61L 2202/122 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/325 (20130101) Original (OR) Class C02F 1/725 (20130101) C02F 2201/3222 (20130101) C02F 2201/3227 (20130101) C02F 2201/3228 (20130101) C02F 2303/04 (20130101) C02F 2305/10 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Reconnaissance Office (NRO)

11788183 — Method for growing crystalline optical films on Si substrates which may optionally have an extremely small optical loss in the infra-red spectrum with hydrogenation of the crystalline optical films

US 11788183	Son et al.
FUNDED BY	National Reconnaissance Office (NRO)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL LABORATORIES, LLC (Malibu, California)
INVENTOR(S)	Kyung-Ah Son (Moorpark, California); Jeong-Sun Moon (Moorpark, California); Hwa Chang Seo (Malibu, California); Richard M. Kremer (Ramona, California); Ryan G. Quarfoth (Malibu, California); Jack A. Crowell (Malibu, California); Mariano J. Taboada (Malibu, California); Joshua M. Doria (Malibu, California); Terry B. Welch (Malibu, California)
ABSTRACT	A process enables growing thick stoichiometric crystalline and preferably IR-transparent optical PCMO material on Si and other substrates. Sputter deposition is carried out in oxygen-free inert gas (e.g., Ar) environment, which helps to prevent decomposition of the PCMO material over the substrate. In the disclosed process, there is no need to add a seed layer prior to PCMO deposition. Moreover, no post-deposition annealing is needed in a high-temperature and high-pressure oxygen furnace, but an anneal provides certain additional benefits in terms of improved transparency at IR wavelengths. Over a long deposition time for a thick PCMO film on the high temperature (≥450° C.) substrates, the PCMO deposition is made repeated cycles of deposition of the PCMO material at the high temperature, each deposition cycle being followed by cooling the PCMO-deposited substrate to a substantially lower temperature (<50° C.). If an anneal is applied in a hydrogen environment that will cause hydrogenation of the PCMO film which yields PCMO films with an extremely small optical loss (i.e., optical extinction coefficient k<0.001) over the entire IR range.
FILED	Friday, March 19, 2021
APPL NO	17/206927
ART UNIT	1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/08 (20130101) Original (OR) Class C23C 14/35 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Security Agency (NSA)

11791525 — Asynchronous reversible flux soliton logic gates

US 11791525	Osborn et al.
FUNDED BY	National Security Agency (NSA)
APPLICANT(S)	The Government of the United States as represented by the Director, National Security Agency (Ft. George G. Meade, Maryland)
ASSIGNEE(S)	Government of the United States as represented by the Director, National Security Agency (, None)
INVENTOR(S)	Kevin D. Osborn (Clarksville, Maryland); Waltraut Wustmann (Dunedin, New Zealand)
ABSTRACT	A reversible superconducting circuit includes two Josephson transmission lines. Inductors connect Josephson Junctions in the array. Each transmission line passes a fluxon along the Junctions. The circuit includes an interface with first and second shunt capacitors coupled to the first and second transmission lines, and a third shunt capacitor, forming a connecting circuit with the first and second shunt capacitors. The shunt capacitors include Josephson junctions in parallel. The connecting circuit receives an input fluxon and transmits an output fluxon. The circuit also includes a Josephson Junction and inductor in parallel with the third shunt capacitor, forming a storage circuit. The storage circuit stores a SFQ. The output fluxon has polarity based on the SFQ stored when the first fluxon is received. The input fluxon causes the polarity of the stored SFQ to be the same as the polarity of the input fluxon, immediately after the input fluxon is received.
FILED	Tuesday, January 11, 2022
APPL NO	17/572885
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Static Stores G11C 19/32 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/026 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Small Business Administration (SBA)

11786859 — Air separation sorbent and vacuum assisted pressure swing adsorption process using the same

US 11786859	Alptekin et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) United States Marine Corps (USMC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	TDA Research, Inc (Wheat Ridge, Colorado)
ASSIGNEE(S)	TDA Research, Inc. (Wheat Ridge, Colorado)
INVENTOR(S)	Gökhan O. Alptekin (Boulder, Colorado); Douwe Bruinsma (Louisville, Colorado); Ambalavanan Jayaraman (Highlands Ranch, Colorado); Brandon Gushlaw (Boulder, Colorado)
ABSTRACT	A vacuum assisted pressure swing adsorption device for purifying oxygen from air, comprising: a first adsorption bed of LiLSX adsorbent and second adsorption bed of AgLiLSX adsorbent, wherein the first adsorption bed and the second adsorption bed are connected to each other in series. A method for producing medical oxygen using a vacuum assisted pressure swing adsorption device comprising: a first adsorption bed of LiLSX adsorbent and second adsorption bed of AgLiLSX adsorbent, wherein the first adsorption bed and the second adsorption bed are connected to each other in series.
FILED	Thursday, February 04, 2021
APPL NO	17/168147
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Separation B01D 53/0407 (20130101) B01D 53/0476 (20130101) Original (OR) Class B01D 2253/304 (20130101) B01D 2256/12 (20130101) B01D 2257/104 (20130101) B01D 2259/402 (20130101) B01D 2259/4533 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

11789065 — Temperature compensated current source for cryogenic electronic testing

US 11789065	Allwine et al.
FUNDED BY
APPLICANT(S)	Scott F. Allwine (Leesburg, Virginia); Sunny Bagga (Corona, California); Brian J. Cadwell (Pasadena, Maryland); Shaun Mark Goodwin (East New Market, Maryland)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Scott F. Allwine (Leesburg, Virginia); Sunny Bagga (Corona, California); Brian J. Cadwell (Pasadena, Maryland); Shaun Mark Goodwin (East New Market, Maryland)
ABSTRACT	This disclosure relates to systems and methods for current source temperature compensation for use during cryogenic electronic testing. A temperature compensation circuit can provide a temperature compensation signal to a current source circuit configured to provide an electrical current for testing a cryogenic device under test to compensate for temperature effects on the current source circuit based on a time constant adjustment signal. The time constant adjustment signal can adjust a time constant of the temperature compensation circuit to delay by a given amount of time that the temperature compensation circuit compensates for the temperature effects on the current source circuit. A controller can be configured to execute a temperature compensation method to provide the time constant adjustment signal based on at least one temperature signal characterizing a temperature of an environment that includes the current source circuit or a temperature of the current source circuit.
FILED	Thursday, June 02, 2022
APPL NO	17/830697
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 3/005 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 19/1659 (20130101) G01R 31/2877 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

What You'll Find On This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, October 17, 2023.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
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FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
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