FedInvent™ Patents
Patent Details for Tuesday, December 19, 2023
This page was updated on Tuesday, December 19, 2023 at 02:56 PM GMT
Department of Health and Human Services (HHS)
| US 11844336 | Nakauchi et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF TOKYO (Bunkyo-ku, Japan); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE UNIVERSITY OF TOKYO (Bunkyo-ku, Japan); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Hiromitsu Nakauchi (Tokyo, Japan); Hideki Masaki (Tokyo, Japan); Motoo Watanabe (Tokyo, Japan); Irving Weissman (Stanford, California) |
| ABSTRACT | The present invention provides a method for producing a chimeric animal using a primed pluripotent stem cell, a tissue stem cell, a progenitor cell, a somatic cell, or a germ cell. The method for producing a chimeric animal according to the present invention comprises introducing a mammal-derived cell into the embryo of a mammal, the cell being primed pluripotent stem cell, tissue stem cell, progenitor cell, somatic cell, or germ cell. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 16/857855 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) Original (OR) Class A01K 2207/12 (20130101) A01K 2227/105 (20130101) Peptides C07K 14/4747 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0607 (20130101) C12N 5/0696 (20130101) C12N 2501/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844571 | Dana et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| INVENTOR(S) | Reza Dana (Newton, Massachusetts); Francisco L. Amparo Pulido (Cambridge, Massachusetts); Haobing Wang (Newton, Massachusetts) |
| ABSTRACT | The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738783 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/14 (20130101) A61B 3/0025 (20130101) Original (OR) Class A61B 3/1025 (20130101) A61B 5/0071 (20130101) A61B 5/1032 (20130101) A61B 5/4848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844615 | Berenfeld |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Omer Berenfeld (Ann Arbor, Michigan) |
| ABSTRACT | Techniques are provided that identify and localize on to reentrant and ectopic patterns of electrical activation in the heart wall. These patterns may correspond to atrial fibrillation, ventricular fibrillation, or other heart arrhythmia conditions. The techniques detect these patterns of electrical activity using a multi-lead an intra-cavitary catheter that, along with a controller, is able to track, over a multi-dimensional cubic space, reentrant activity and identify filaments in the heart cavity. The intra-cavitary catheter includes multiple conducting poles positioned in a configuration relative to each other and functioning as either or both sensing and active poles for measuring electrical pathways in the heart wall and over the multi-dimensional space. |
| FILED | Friday, February 12, 2016 |
| APPL NO | 15/042681 |
| ART UNIT | 3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/287 (20210101) Original (OR) Class A61B 5/316 (20210101) A61B 5/339 (20210101) A61B 5/361 (20210101) A61B 5/364 (20210101) A61B 5/6852 (20130101) A61B 2562/0214 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844648 | Waag et al. |
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| APPLICANT(S) | Habico, Inc. (Honey Falls, New York) |
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| INVENTOR(S) | Robert C. Waag (Buffalo, New York); Jeffrey P. Astheimer (Honey Falls, New York) |
| ABSTRACT | A device, system, and method for volumetric ultrasound imaging is described. The device and system include an array of transducer elements grouped in triangular planar facets and substantially configured in the shape of a hemisphere to form a cup-shaped volumetric imaging region within the cavity of the hemisphere, A plurality of data-acquisition assemblies are connected to the transducers, which are configured to collect ultrasound signals received from the transducers and transmit image data to a network of processors that are configured to construct a volumetric image of an object within the imaging region based on the image data received from the data-acquisition assemblies. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507319 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) A61B 8/14 (20130101) Original (OR) Class A61B 8/406 (20130101) A61B 8/483 (20130101) A61B 8/0825 (20130101) A61B 8/4281 (20130101) A61B 8/4483 (20130101) A61B 8/4494 (20130101) A61B 8/5207 (20130101) A61B 8/5269 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/8915 (20130101) G01S 15/8929 (20130101) G01S 15/8959 (20130101) G01S 15/8977 (20130101) G01S 15/8993 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844666 | Flusberg et al. |
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| APPLICANT(S) | Pacific Biosciences of California, Inc. (Menlo Park, California) |
| ASSIGNEE(S) | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (Menlo Park, California) |
| INVENTOR(S) | Benjamin Flusberg (Atlanta, Georgia); Jonas Korlach (Camas, Washington); Andrey Kislyuk (San Ramon, California); Stephen Turner (Seattle, Washington); Jon Sorenson (Alameda, California); Kevin Travers (Menlo Park, California); Cheryl Heiner (La Honda, California); Austin B. Tomaney (Burlingame, California); Patrick Marks (San Francisco, California); Dale Webster (San Mateo, California); Jeremiah Hanes (Menlo Park, California) |
| ABSTRACT | Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid. |
| FILED | Thursday, March 23, 2023 |
| APPL NO | 18/189084 |
| ART UNIT | 1671 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/32 (20130101) A61F 2/40 (20130101) A61F 2/30721 (20130101) Original (OR) Class A61F 2/30767 (20130101) A61F 2/30965 (20130101) A61F 2002/4635 (20130101) A61F 2002/30004 (20130101) A61F 2002/30062 (20130101) A61F 2002/30235 (20130101) A61F 2002/30242 (20130101) A61F 2002/30245 (20130101) A61F 2002/30324 (20130101) A61F 2002/30593 (20130101) A61F 2002/30757 (20130101) A61F 2002/30971 (20130101) A61F 2210/0004 (20130101) A61F 2230/0069 (20130101) A61F 2230/0071 (20130101) A61F 2250/0014 (20130101) A61F 2250/0036 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) C12Q 1/6869 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844724 | Grubbs et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); The Regents of the University of California (Oakland, California); United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); The Regents of the University of California (Oakland, California); United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Robert H. Grubbs (South Pasadena, California); Marshall L Stoller (San Francisco, California); Ying Han (Burlingame, California); Frank L. Brodie (Durham, North Carolina) |
| ABSTRACT | A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509641 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00745 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844769 | Rubin et al. |
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| FUNDED BY |
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| APPLICANT(S) | MESHABERASE, LLC (Potomac, Maryland); The united States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | MESHABERASE, LLC (Potomac, Maryland); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Benjamin Rubin (Potomac, Maryland); Mark Gilbert (Bethesda, Maryland); Jinkyu Jung (Bethesda, Maryland) |
| ABSTRACT | The present Disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or a derivative thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/337095 |
| ART UNIT | 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/28 (20130101) A61K 9/0053 (20130101) A61K 9/4891 (20130101) A61K 31/145 (20130101) Original (OR) Class A61K 31/145 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844775 | Mohsen |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Al-Walid A. Mohsen (Gibsonia, Pennsylvania) |
| ABSTRACT | A method of treating medium chain acyl-CoA dehydrogenase deficiency, very long chain acyl-CoA dehydrogenase deficiency, long chain hydroxyacyl-CoA dehydrogenase deficiency, trifunctional protein deficiency, or CPT II deficiency in a patient is provided comprising administering to the patient a therapeutic amount of a triglyceride or other conjugated fatty acid, that bypasses or leads to an intermediate that bypasses the deficient enzyme. Amino acid-conjugated fatty acids also are provided as well as compositions comprising the amino acid-conjugated fatty acids. |
| FILED | Thursday, July 11, 2019 |
| APPL NO | 17/258877 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/221 (20130101) Original (OR) Class A61K 31/232 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844800 | Shalek et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Alexander K. Shalek (Cambridge, Massachusetts); Peter Winter (Cambridge, Massachusetts); David Weinstock (Boston, Massachusetts); Mark Murakami (Boston, Massachusetts); Scott Manalis (Cambridge, Massachusetts); Andrew Navia (Cambridge, Massachusetts); Jennyfer Galvez-Reyes (Cambridge, Massachusetts) |
| ABSTRACT | Described in exemplary embodiments herein are methods, compositions, and kits for diagnosing, prognosing, monitoring, treating and/or preventing a hemopoietic malignancy and/or relapse thereof in a subject. In some embodiments, the methods can include determining an average cellular mass of cells in a sample from the subject and/or detecting one or more molecular signatures in one or more of the cells. In some embodiments, treatment includes administering one or more BCR-ABL tyrosine kinase inhibitors or a pharmaceutical formulation thereof, one or more pre-BCR signaling pathway inhibitors or a pharmaceutical formulation thereof, one or more p38 MAPK inhibitors or a pharmaceutical formulation thereof; or any combination thereof. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085650 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/403 (20130101) A61K 31/427 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/5383 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 16/2887 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844802 | Boden et al. |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia); The US Govt as represented by the Dept of VA (Washington, District of Columbia) |
| INVENTOR(S) | Scott D. Boden (Atlanta, Georgia); Sreedhara Sangadala (Atlanta, Georgia) |
| ABSTRACT | The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936184 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) Original (OR) Class A61K 31/53 (20130101) A61K 38/1875 (20130101) A61K 2300/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 2300/412 (20130101) A61L 2430/02 (20130101) Heterocyclic Compounds C07D 251/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844815 | Aroian et al. |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| INVENTOR(S) | Raffi Van Aroian (Worcester, Massachusetts); Gary R. Ostroff (Worcester, Massachusetts) |
| ABSTRACT | Compositions and methods for treating or reducing the severity of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a composition comprising isolated native, bioactive nematicidal crystals formed from a single type of nematicidal crystal protein. The isolated native, bioactive nematicidal crystals are substantially free of any bacterial spores or host bacterial proteins, other than nematicidal crystal protein in the form of a crystal. Methods for making isolated native, bioactive nematicidal crystals are also described. The crystal proteins may be full length, truncated, variant, or sub-variant Cry proteins. Examples of crystal proteins include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. |
| FILED | Tuesday, May 22, 2018 |
| APPL NO | 16/607677 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/48 (20130101) A61K 35/741 (20130101) Original (OR) Class A61K 38/164 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844817 | Lal et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | The UAB Research Foundation (Birmingham, Alabama) |
| INVENTOR(S) | Charitharth Vivek Lal (Birmingham, Alabama); Namasivayam Ambalavanan (Birmingham, Alabama); Amit Gaggar (Birmingham, Alabama); Casey Morrow (Birmingham, Alabama) |
| ABSTRACT | The respiratory microbiomes of neonates and those with bronchopulmonary disease have been characterized. Provided are probiotic compositions, which can include at least one living bacterial strain and at least one killed bacterial strain, that can comprise a combination of Lactobacilli species, 5 that when delivered to the bronchi or lungs of a patient can provide a reduction in the symptoms of a bronchopulmonary disease. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/384272 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0078 (20130101) A61K 35/747 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844825 | Montaño-Suarez et al. |
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| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); Pontificia Universidad Javeriana (Bogota, Colombia) |
| ASSIGNEE(S) | Saint Louis University (St. Louis, Missouri) |
| INVENTOR(S) | Adriana M. Montaño-Suarez (St. Louis, Missouri); Angela Catalina Sosa-Molano (Bogota, Colombia); Alan Knutsen (Webster Groves, Missouri); Clifford Bellone (St. Louis, Missouri); Shunji Tomatsu (Wilmington, Delaware); Luis Barrera (Bogota, Colombia) |
| ABSTRACT | Disclosed are methods and compositions for determining immunodominant peptides of target enzymes used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are immunodominant peptides for N-acetylgalactosamine-6-sulfatase (GALNS). Also disclosed are methods of inducing oral tolerance towards a target enzyme through oral administration of immunodominant peptides prior to commencing enzyme replacement therapy. More specifically disclosed is a method of inducing oral tolerance for GALNS, by orally administering specific immunodominant peptides for GALNS; in subjects suffering from mucopolysaccharidosis type IVA prior to commencing enzyme replacement therapy using GALNS. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314510 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 38/465 (20130101) Original (OR) Class Enzymes C12Y 301/06004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844832 | Amanna et al. |
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| FUNDED BY |
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| APPLICANT(S) | Najít Technologies, Inc. (Beaverton, Oregon) |
| ASSIGNEE(S) | Najit Technologies, Inc. (Beaverton, Oregon) |
| INVENTOR(S) | Ian J. Amanna (Hillsboro, Oregon); Elizabeth A. Poore (Portland, Oregon) |
| ABSTRACT | Provided are methods for rapidly inactivating a pathogen, or for producing a vaccine composition containing an inactivated noninfectious pathogen having retained antigenicity and/or immunogenicity, comprising exposing the pathogen to a chemical inactivating agent (e.g., one or more chemical oxidizing, alkylating or crosslinking agents) in the presence of inorganic polyatomic oxyanions in an amount and for a time sufficient to render the pathogen noninfectious while enhancing retention of pathogen antigenicity and/or immunogenicity relative to that retained by contacting the pathogen with the chemical inactivating agent alone. The methods are broadly applicable to pathogens having RNA or DNA genomes (e.g., including viruses, bacteria, fungi, and parasites). Also provided are vaccine compositions (medicaments) containing a pathogen inactivated by exposure to an inactivating agent in the presence of elevated concentrations of inorganic polyatomic oxyanions, and methods for eliciting an immune response in a subject by administering the vaccine compositions. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 16/994500 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/40 (20130101) A61K 39/02 (20130101) A61K 39/12 (20130101) A61K 39/105 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 39/275 (20130101) A61K 39/0283 (20130101) A61K 2039/521 (20130101) A61K 2039/5252 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16131 (20130101) C12N 2760/16134 (20130101) C12N 2760/16163 (20130101) C12N 2760/16171 (20130101) C12N 2770/24134 (20130101) C12N 2770/24163 (20130101) C12N 2770/24171 (20130101) C12N 2770/36134 (20130101) C12N 2770/36163 (20130101) C12N 2770/36171 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844833 | Wussow et al. |
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| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Felix Wussow (Monrovia, California); Don J. Diamond (Glendora, California) |
| ABSTRACT | An expression system for expressing a herpesvirus glycoprotein complex including a vector inserted with two or more nucleic acid sequences that encode two or more subunits of a herpesvirus glycoprotein complex linked by one or more linking sequences such that the subunits are co-expressed simultaneously and self-processed to assemble into a glycoprotein complex. The expression system or the vector can be included in a vaccine composition. The vaccine composition can be used for preventing or treating herpesvirus infections. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/806157 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/245 (20130101) Original (OR) Class Peptides C07K 14/05 (20130101) C07K 14/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844846 | Ye |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| INVENTOR(S) | Keqiang Ye (Lilburn, Georgia) |
| ABSTRACT | This disclosure relates to styrylbenzothiazole derivatives for use as in vivo imaging agents for the diagnosis of Parkinson's disease (PD) or other degenerative disorders or conditions of the central nervous system. Early diagnosis is particularly advantageous as neuroprotective treatment can be applied to healthy neural cells to delay or even prevent the onset of debilitating clinical symptoms. |
| FILED | Thursday, May 16, 2019 |
| APPL NO | 17/055935 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0453 (20130101) Original (OR) Class General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844919 | Lalwani et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Anil K. Lalwani (New York, New York); Jeffrey W. Kysar (New York, New York); Aykut Aksit (New York, New York); Daniel N. Arteaga (New York, New York) |
| ABSTRACT | The disclosed subject matter relates to a cleavable microneedle for delivery of therapeutic agent, wherein the needle includes a longitudinal body having a detachable portion that comprises at least one therapeutic agent. The microneedle may be configured to administer the therapeutic agent to the inner ear of a subject. Also disclosed is a method for preparing a microneedle using two-photon polymerization lithography. |
| FILED | Thursday, January 03, 2019 |
| APPL NO | 16/960033 |
| ART UNIT | 3783 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/003 (20130101) A61M 2037/0023 (20130101) A61M 2037/0046 (20130101) A61M 2037/0053 (20130101) A61M 2037/0061 (20130101) A61M 2210/0612 (20130101) A61M 2210/0662 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845084 | Ganguli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois); Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois); Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Anurup Ganguli (Urbana, Illinois); Rashid Bashir (Champaign, Illinois); Panagiotis Z. Anastasiadis (Jacksonville, Florida); George Vasmatzis (Oronoco, Minnesota) |
| ABSTRACT | Provided are methods and related devices for preparing a cell and tissue culture, including a hanging drop culture. Microwells are specially loaded with cell mixtures using a removable reservoir and forcing cells into the underlying microwells. The removable reservoir is removed and the cells partitioned into the individual microwells and covered by an immiscible layer of fluid. The microwells and immiscible layer is inverted and the cells in the microwells cultured. The microwells may have shape-controlling elements to control the three-dimensional shape of the culture. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307150 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0262 (20130101) B01L 3/5088 (20130101) Original (OR) Class B01L 9/523 (20130101) B01L 2400/024 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845676 | Pentecost et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PHS SOLUTIONS LLC. (Ludlow Falls, Ohio) |
| ASSIGNEE(S) | PHS SOLUTIONS LLC. (Ludlow Falls, Ohio) |
| INVENTOR(S) | Randy J. Pentecost (Central City, Kentucky); Bryan S. Hall (Salyersville, Kentucky); Fred A. Sink (Ludlow Falls, Ohio) |
| ABSTRACT | A transitional water treatment wall for kidney dialysis is provided. The transitional wall includes several devices positioned on a mobile frame, the devices establishing fluid communication between a water source, pre-RO treatment equipment, and an RO system. The transitional water treatment wall also provides pressure and temperature control of the water being circulated. The mobile frame of the transitional water treatment wall includes wheels for providing ease of movement of the transitional water treatment wall. The mobile frame also limits space requirements for the various devices. The transitional wall also includes electrical outlets. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/860732 |
| ART UNIT | 1778 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) Original (OR) Class C02F 2201/004 (20130101) C02F 2201/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845741 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATION (Richmond, Virginia) |
| ASSIGNEE(S) | VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATION (Richmond, Virginia) |
| INVENTOR(S) | Juan Wang (Richmond, Virginia); Hu Yang (Glen Allen, Virginia) |
| ABSTRACT | The present disclosure provides pilocarpine ionic liquid analogs useful in the treatment of ophthalmological disorders such as glaucoma. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478187 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/4178 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) Heterocyclic Compounds C07D 405/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845777 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Linling He (San Diego, California); Jiang Zhu (San Diego, California); Ian A. Wilson (La Jolla, California) |
| ABSTRACT | The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/087704 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 2039/57 (20130101) A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845778 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); Institute for Research in Biomedicine (Bellinzona, Switzerland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); Institute for Research in Biomedicine (Bellinzona, Switzerland) |
| INVENTOR(S) | Baoshan Zhang (Bethesda, Maryland); Guillaume Stewart-Jones (Bethesda, Maryland); John Mascola (Rockville, Maryland); Kai Xu (Bethesda, Maryland); Gwo-Yu Chuang (Rockville, Maryland); Li Ou (Bethesda, Maryland); Peter Kwong (Washington, District of Columbia); Yaroslav Tsybovsky (Jefferson, Maryland); Wing-Pui Kong (Germantown, Maryland); Aliaksandr Druz (Germantown, Maryland); Davide Corti (Bellinzona, Switzerland); Antonio Lanzavecchia (Bellinzona, Switzerland) |
| ABSTRACT | Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/378587 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/18634 (20130101) C12N 2760/18734 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845785 | Gladwin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh Of the CommonwealthSystem of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Mark T. Gladwin (Pittsburgh, Pennsylvania); Jesus Tejero Bravo (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity. The monomeric mutant globins are infused into blood, where they rapidly and irreversibly sequester carbon monoxide, and thus limit toxic effects of carbon monoxide on cellular respiration and oxygen transport and utilization. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 16/951529 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/00 (20130101) A61K 38/41 (20130101) Peptides C07K 14/795 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845789 | Chan-Hui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THERACLONE SCIENCES, INC. (Seattle, Washington); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); INTERNATIONAL AIDS VACCINE INITIATIVE, INC. (New York, New York) |
| ASSIGNEE(S) | THERACLONE SCIENCES, INC. (Seattle, Washington); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); INTERNATIONAL AIDS VACCINE INITIATIVE, INC. (New York, New York) |
| INVENTOR(S) | Po-Ying Chan-Hui (Bellevue, Washington); Katherine Doores (San Diego, California); Michael Huber (Zurich, Switzerland); Stephen Kaminsky (Bronx, New York); Steven Frey (Redmond, Washington); Ole Olsen (Everett, Washington); Jennifer Mitcham (Redmond, Washington); Matthew Moyle (Redmond, Washington); Sanjay K. Phogat (Frederick, Maryland); Dennis R. Burton (La Jolla, California); Laura Majorie Walker (San Diego, California); Pascal Raymond Georges Poignard (San Diego, California); Wayne Koff (Stony Brook, New York); Melissa Danielle De Jean De St. Marcel Simek-Lemos (Brooklyn, New York) |
| ABSTRACT | The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/376276 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/51 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16111 (20130101) C12N 2740/16122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845803 | Riddell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Stanley R. Riddell (Sammamish, Washington); Damian Green (Seattle, Washington); Tyler Hill (Seattle, Washington) |
| ABSTRACT | The present disclosure relates to methods for using BCMA-specific binding molecules (such as a BCMA-specific chimeric antigen receptor or antibody) in combination with γ-secretase inhibitors, which can be done concurrently or sequentially, to treat or prevent a B-cell related proliferative disease, such as a cancer or autoimmune disease, or the like. A BCMA-specific binding molecule in combination with γ-secretase inhibitor can be used in, for example, adoptive immunotherapy. |
| FILED | Friday, February 16, 2018 |
| APPL NO | 16/486764 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/192 (20130101) A61K 31/216 (20130101) A61K 31/417 (20130101) A61K 31/4245 (20130101) A61K 31/5513 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/52 (20130101) C07K 14/475 (20130101) C07K 16/40 (20130101) C07K 16/2878 (20130101) Original (OR) Class C07K 16/2887 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845807 | Szeto et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell Research Foundation, Inc. (New York, New York) |
| ASSIGNEE(S) | Cornell Research Foundation, Inc. (New York, New York) |
| INVENTOR(S) | Hazel H. Szeto (New York, New York); Kesheng Zhao (Jackson Heights, New York); Hugh Robertson (New York, New York); Alex V. Birk (New York, New York) |
| ABSTRACT | The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide. |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/521425 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 38/47 (20130101) A61K 47/64 (20170801) A61K 47/645 (20170801) Peptides C07K 5/08 (20130101) C07K 5/1016 (20130101) C07K 5/1019 (20130101) C07K 17/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/96 (20130101) C12N 9/2471 (20130101) C12N 15/87 (20130101) C12N 15/113 (20130101) C12N 2310/3513 (20130101) C12N 2320/32 (20130101) Enzymes C12Y 302/01023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845920 | Chou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David Benson Chou (Boston, Massachusetts); Liliana S. Teixeira Moreira Leijten (Maastricht, Netherlands); Arianna Rech (Leicestershire, United Kingdom); Richard Novak (Jamaica Plain, Massachusetts); Donald E. Ingber (Boston, Massachusetts); Yuka Milton (Cambridge, Massachusetts); Viktoras Frismantas (Roxburg Crossing, Massachusetts); Oren Levy (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure relates to a microfluidic devices and methods for culturing bone marrow cells. Aspects include methods of preparing microfluidic devices and culturing bone marrow cells with the microfluidic devices. In some aspects, a method includes providing a microfluidic device having an upper chamber, a lower chamber, and a porous membrane separating the upper chamber from the lower chamber. The method further includes seeding walls of the lower chamber and a bottom surface of the membrane with endothelial cells. The method further includes providing a matrix within the upper chamber. The matrix includes fibrin gel and bone marrow cells. The method further includes filling or perfusing the upper chamber with a media. |
| FILED | Monday, March 26, 2018 |
| APPL NO | 16/496997 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2300/12 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) C12M 29/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0669 (20130101) C12N 2501/40 (20130101) C12N 2501/999 (20130101) C12N 2502/28 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845929 | Dong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| INVENTOR(S) | Yizhou Dong (Dublin, Ohio); Bin Li (Columbus, Ohio) |
| ABSTRACT | The present disclosure generally relates to genome editing systems and methods and compounds and compositions for use in Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) genome editing systems. Disclosed herein are modified nucleic acids that modulate the activity of genome editing. |
| FILED | Friday, July 07, 2017 |
| APPL NO | 16/316135 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2310/113 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/3521 (20130101) C12N 2310/3533 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845950 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Cork, Ireland) |
| ABSTRACT | Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/894141 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845955 | Jenkins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER (Cleveland, Ohio) |
| ASSIGNEE(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); NATIONAL INSTITUTES OF HEALTH (NIH) (Bethesda, Maryland); U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS) (Bethesda, Maryland); U.S. GOVERNMENT NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR) (Bethesda, Maryland) |
| INVENTOR(S) | Michael W. Jenkins (Cleveland, Ohio); Yehe Liu (Cleveland, Ohio) |
| ABSTRACT | The present disclosure relates to a simple, fast, and low cost method for 3D microvascular imaging, termed “scatter labeled imaging of microvasculature in excised tissue” (SLIME). The method can include perfusing a contrast agent through vasculature of a tissue sample. The contrast agent can include colloids and a dispersant. After the contrast agent is perfused through the vasculature, the vasculature of the tissue sample can be treated with a molecule that cross links with at least a portion of the dispersant to form a sticky, non-Newtonian polymer that prevents leakage of the contrast agent out of the vasculature of the tissue sample. The tissue sample can then be immersed in a solution comprising a clearing agent and subsequently imaged. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878438 |
| ART UNIT | 2664 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) Original (OR) Class C12N 5/0679 (20130101) C12N 5/0691 (20130101) C12N 2513/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/49 (20130101) G01N 21/4795 (20130101) G01N 33/4833 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/009 (20130101) G06T 5/20 (20130101) G06T 5/50 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 7/136 (20170101) G06T 2207/10101 (20130101) G06T 2207/20224 (20130101) G06T 2207/30024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845958 | Sherer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Nathan Mark Sherer (Madison, Wisconsin); Ryan Thomas Behrens (Madison, Wisconsin) |
| ABSTRACT | Genetically modified CCNT1 and XPO1 genes encoding proteins that inhibit virus infection in cells. The genetically modified CCNT1 gene encodes a protein with a C261Y substitution with respect to the human CCNT1 protein. The genetically modified XPO1 gene encodes a protein with P411T, M412V, and/or F414S substitutions with respect to the human XPO1 protein. The genetically modified CCNT1 and XPO1 genes can be introduced in cells. The cells comprising the genetically modified CCNT1 and XPO1 genes can be introduced in a subject with a virus infection to treat the infection. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 16/561847 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 38/16 (20130101) Peptides C07K 14/705 (20130101) C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) Original (OR) Class C12N 15/00 (20130101) C12N 15/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845959 | Mikkola et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Hanna Mikkola (Los Angeles, California); Vincenzo Calvanese (Los Angeles, California); Andrew T. Nguyen (Los Angeles, California) |
| ABSTRACT | Transient MLLT3 overexpression in culture may be used to expand human HSCs in vitro, and thereby improve the efficiency and safety of HSC transplantation. |
| FILED | Friday, June 16, 2017 |
| APPL NO | 16/310206 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) A01K 2227/105 (20130101) A01K 2267/02 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 5/0696 (20130101) C12N 15/85 (20130101) C12N 15/861 (20130101) C12N 2501/60 (20130101) C12N 2501/727 (20130101) C12N 2502/1171 (20130101) C12N 2502/1352 (20130101) C12N 2502/1394 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845960 | Ng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Hon Man Alex Ng (Cambridge, Massachusetts); George M. Church (Cambridge, Massachusetts); Volker Busskamp (Cambridge, Massachusetts) |
| ABSTRACT | Forced expression of a handful of transcription factors (TFs) can induce conversions between cell identities; however, the extent to which TFs can alter cell identity has not been systematically assessed. Here, we assembled a human TFome, a comprehensive expression library of 1,578 human TF clones with full coverage of the major TF families. By systematically screening the human TFome, we identified 77 individual TFs that induce loss of human-induced-pluripotent-stem-cell (hiPSC) identity, suggesting a pervasive ability for TFs to alter cell identity. Using large-scale computational cell type classification trained on thousands of tissue expression profiles, we identified cell types generated by these TFs with high efficiency and speed, without additional selections or mechanical perturbations. TF expression in adult human tissues only correlated with some of the cell lineage generated, suggesting more complexity than observation studies can explain. |
| FILED | Tuesday, September 12, 2017 |
| APPL NO | 16/332350 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Original (OR) Class C12N 5/0605 (20130101) C12N 5/0623 (20130101) C12N 5/0626 (20130101) C12N 5/0658 (20130101) C12N 5/0662 (20130101) C12N 5/0686 (20130101) C12N 5/0696 (20130101) C12N 2501/60 (20130101) C12N 2503/02 (20130101) C12N 2506/45 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845961 | Tuan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Rocky S. Tuan (Pittsburgh, Pennsylvania); Hang Lin (Pittsburgh, Pennsylvania); Thomas P. Lozito (Pittsburgh, Pennsylvania); Peter Alexander (Wexford, Pennsylvania); Douglas Allen Nelson, Jr. (Pittsburgh, Pennsylvania); Riccardo Gottardi (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/151921 |
| ART UNIT | 1796 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/34 (20130101) C12M 35/04 (20130101) C12M 35/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) Original (OR) Class C12N 2502/1311 (20130101) C12N 2502/1317 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845967 | Colecraft et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Henry M. Colecraft (Robbinsville, New Jersey); Scott Kanner (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 16/867923 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6472 (20130101) Original (OR) Class C12N 15/85 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 304/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845970 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland) |
| INVENTOR(S) | Lai-Xi Wang (Ellicott City, Maryland); Qiang Yang (Ellicott City, Maryland); Tiezheng Li (Columbia, Maryland); Xin Tong (College Park, Maryland) |
| ABSTRACT | The present invention provides for recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/320703 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 35/00 (20180101) Peptides C07K 16/32 (20130101) C07K 16/2887 (20130101) C07K 2317/41 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class Enzymes C12Y 302/01096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845987 | Joung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Vikram Pattanayak (Wellesley, Massachusetts); Karl Petri (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions for performing highly sensitive in vitro assays to define substrate preferences and off-target sites of nucleic-acid binding, modifying, and cleaving agents. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 16/852257 |
| ART UNIT | 1675 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1058 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845992 | Cornell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Liam Cornell (Brookline, Massachusetts); Geoffrey I. Shapiro (Boston, Massachusetts) |
| ABSTRACT | The present invention relates to compositions and methods for detecting CDK4/6 response and resistance. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157653 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/519 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2310/531 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/166 (20130101) C12Q 2600/178 (20130101) Enzymes C12Y 207/11022 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) G16B 30/00 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845994 | Velculescu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); University of Torino (Turin, Italy) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland); University of Torino (Turin, Italy) |
| INVENTOR(S) | Victor E. Velculescu (Dayton, Maryland); Eniko Papp (Baltimore, Maryland); Vilmos Adleff (Baltimore, Maryland); Andrea Bertotti (Turin, Italy); Livio Trusolino (Turin, Italy) |
| ABSTRACT | Recent large-scale analyses have demonstrated that the genomic landscape of human cancer is complex and variable among individuals of the same tumor type. Such underlying genetic differences may in part be responsible for the varying therapeutic responses observed in cancer patients. To examine the effect of somatic genetic changes in colorectal cancer on sensitivity to a common targeted therapy, we performed complete exome sequence and copy number analyses of 129 tumors that were KRAS wild-type and analyzed their response to anti-EGFR antibody blockade in patient-derived tumorgraft models. In addition to previously identified genes, we detected mutations in ERBB2, EGFR, FGFR1, PDGFRA, and MAP2K1 as potential mechanisms of primary resistance to this therapy. Alterations in the ectodomain of EGFR were identified in patients with acquired resistance to EGFR blockade. Amplifications and sequence changes in the tyrosine kinase receptor adaptor gene IRS2 were identified in tumors with increased sensitivity to anti-EGFR therapy. Therapeutic resistance to EGFR blockade could be overcome in tumorgraft models through combinatorial therapies targeting actionable genes. These analyses provide a systematic approach to evaluate response to targeted therapies in human cancer, highlight additional mechanisms of responsiveness to anti-EGFR therapies, and provide additional avenues for intervention in the management of colorectal cancer. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225717 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/395 (20130101) A61K 2039/55 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2863 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846611 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NUTECH VENTURES (Lincoln, Nebraska); UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | NUTECH VENTURES (Lincoln, Nebraska); UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Ruiguo Yang (Lincoln, Nebraska); Nikolay V. Lavrik (Knoxville, Tennessee); Amir Monemian Esfahani (Lincoln, Nebraska); Jordan Daniel Rosenbohm (Lincoln, Nebraska); Bahareh Tajvidi Safa (Lincoln, Nebraska); Grayson Minnick (Lincoln, Nebraska) |
| ABSTRACT | A method of measuring a stress-strain curve in a cell-cell adhesion interface, the method including: providing a structure including a first movable island supported by a first beam, a second movable island supported by a second beam, and a gap therebetween connected by a pair of cells forming a junction, the pair of cells comprising a cell-cell adhesion interface having an initial length defined by a distance between nuclei of the pair of cells; moving the second movable island with a defined displacement; determining a displacement of the first movable island based on moving the second movable island; calculating a difference between the displacement of the first movable island and the defined displacement of the second movable island based on moving the second movable island; determining an applied strain in the cell-cell adhesion interface between the pair of cells based on the difference divided by the initial length of the cell-cell adhesion interface; calculating a force between the cell-cell adhesion interface of the pair of cells based on the displacement of the first movable island; calculating a stress in the cell-cell adhesion interface between the pair of cells based on the force; and determining the stress-strain curve of the cell-cell adhesion interface between the pair of cells by plotting the calculated stress against the applied strain. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473090 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/06 (20130101) G01N 3/08 (20130101) Original (OR) Class G01N 19/04 (20130101) G01N 2203/0089 (20130101) G01N 2203/0286 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/26 (20130101) G01Q 60/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846612 | Ferracane et al. |
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| FUNDED BY |
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| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | Jack Ferracane (Portland, Oregon); Carmem Pfeifer (Portland, Oregon); Rafael Tiago Patzlaff (Luzerna-Santa Catarina, Brazil) |
| ABSTRACT | A compact material testing system is configured to expose multiple samples housed within separate sample chambers to simulated fluid, thermal, and mechanical loading conditions. The system includes multiple independent load actuators positioned to extend actuator rods into corresponding sample chambers to apply mechanical loading to the test sample within. A fluid control system is included to bathe each test sample in a fluid medium and replenish the fluid medium within its sample chamber as needed. Each sample chamber includes a gas inlet and gas outlet to provide non-turbulent circulation and control of atmospheric composition above the fluid medium inside the chamber. A logic programmable controller is provided for input of test parameters and automated simultaneous control of mechanical loading, fluid flow, and temperature in the sample chambers. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/660204 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/12 (20130101) Original (OR) Class G01N 2203/0044 (20130101) G01N 2203/0208 (20130101) G01N 2203/0226 (20130101) G01N 2203/0242 (20130101) G01N 2203/0676 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846621 | Lebedev et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trace-Ability, Inc. (Van Nuys, California) |
| ASSIGNEE(S) | Trace-Ability, Inc. (Van Nuys, California) |
| INVENTOR(S) | Artem Y. Lebedev (Santa Monica, California); Arkadij M. Elizarov (Woodland Hills, California) |
| ABSTRACT | A method of determining a radioactivity characteristic of a radioactive sample comprises positioning the radioactive sample on a plate, positioning the plate containing the radioactive sample in an optical plate reader, obtaining luminescence data via the optical plate reader based on light emitted from the plate containing the radioactive sample, and determining a radioactivity characteristic of the radioactive sample based on the luminescence data. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085296 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/037 (20130101) Apparatus for Enzymology or Microbiology; C12M 41/36 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/51 (20130101) G01N 21/78 (20130101) G01N 21/82 (20130101) G01N 21/253 (20130101) G01N 33/15 (20130101) Original (OR) Class G01N 2021/752 (20130101) G01N 2033/0093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846622 | Johnson, Jr. et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Alan T. Johnson, Jr. (Philadelphia, Pennsylvania); Jinglei Ping (Gaithersburg, Maryland); Steven Vitale (Collingswood, New Jersey); Chengyu Wen (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are aptamer-functionalized graphene sensors, capable of detecting various analytes, including toxins, at comparatively low concentrations. Also provided are methods of fabricating and using such aptamer-functionalized graphene sensors. |
| FILED | Tuesday, March 12, 2019 |
| APPL NO | 16/299615 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/04 (20130101) G01N 33/1813 (20130101) Original (OR) Class G01N 33/1826 (20130101) G01N 2410/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846628 | Jackson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Meyer Jackson (Madison, Wisconsin); Masoud Sepehri Rad (Madison, Wisconsin) |
| ABSTRACT | As described herein, a hybrid voltage sensor genetically-encoded voltage indicator (GEVI) for mitochondria or endoplasmic reticulum includes a transmembrane domain, and a fluorescent protein, wherein a terminus of the transmembrane domain and a terminus of the fluorescent protein are covalently linked directly or by a linker comprising 1 to 20 amino acids, and wherein the transmembrane domain comprises SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or a peptide with greater than 85%, 90%, 95% or 98% identity to SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4. Also described are expression vectors, expression cassettes, and organelle membranes, as well as methods of determining the voltage across an organelle using the GEVIs. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893530 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 14/705 (20130101) C07K 2319/03 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) Enzymes C12Y 114/14001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) Original (OR) Class G01N 33/5076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846629 | Rappaport et al. |
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| FUNDED BY |
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| APPLICANT(S) | Temple University Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Tulane University (New Orleans, Louisiana) |
| INVENTOR(S) | Jay Rappaport (Somers Point, New Jersey); Sarah Vakili (Philadelphia, Pennsylvania) |
| ABSTRACT | The invention provides monocytes expressing CD16 and CD163 and experimental system for drug screening or evaluating drug candidates where the modulation of CD16 and CD163 is desired. |
| FILED | Wednesday, September 20, 2017 |
| APPL NO | 16/334808 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 14/70514 (20130101) C07K 14/70535 (20130101) C07K 14/70596 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0645 (20130101) C12N 2501/22 (20130101) C12N 2501/24 (20130101) C12N 2501/25 (20130101) C12N 2501/30 (20130101) C12N 2501/39 (20130101) C12N 2501/052 (20130101) C12N 2501/999 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5047 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846630 | Su et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | Northeastern University (Boston, Massachusetts) |
| INVENTOR(S) | Ming Su (Newton, Massachusetts); Qingxuan Li (Boston, Massachusetts); Liyuan Ma (Newton, Massachusetts); Sidi A. Bencherif (Boston, Massachusetts); Thibault Colombani (Boston, Massachusetts) |
| ABSTRACT | Disclosed is a technology for assaying individual cells, in which the identity of each individual cell in an ordered array is determined from coordinates assigned to it, and can be readout at high throughput with microscope. The method is able to test responses of millions of identical cells in multiple chemical and physical processes with superior statistics power to facilitate deep data mining. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 16/811785 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 41/36 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0693 (20130101) C12N 13/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6408 (20130101) G01N 21/6428 (20130101) G01N 27/02 (20130101) G01N 33/505 (20130101) Original (OR) Class G01N 33/5011 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846639 | Birnbaum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Michael Edward Birnbaum (Stanford, California); Juan Luis Mendoza (Redwood City, California); Michael Thomas Bethune (Pasadena, California); David Baltimore (Pasadena, California); Kenan Christopher Garcia (Menlo Park, California) |
| ABSTRACT | Compositions and methods are provided for the identification of peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/378310 |
| ART UNIT | 1675 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 14/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) Original (OR) Class G01N 2333/7051 (20130101) G01N 2333/70539 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846690 | Basser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Peter J. Basser (Washington, District of Columbia); Dan H. Benjamini (Rockville, Maryland) |
| ABSTRACT | Multi-dimensional spectra associated with a specimen are reconstructed using lower dimensional spectra as constraints. For example, a two-dimensional spectrum associated with diffusivity and spin-lattice relaxation time is obtained using one-dimensional spectra associated with diffusivity and spin-lattice relaxation time, respectively, as constraints. Data for a full two dimensional spectrum are not acquired, leading to significantly reduced data acquisition times. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863846 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/08 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/448 (20130101) G01R 33/465 (20130101) Original (OR) Class G01R 33/4625 (20130101) G01R 33/4633 (20130101) G01R 33/56341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846692 | Dou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Quan Dou (Charlottesville, Virginia); Zhixing Wang (Charlottesville, Virginia); Xue Feng (Zion Crossroads, Virginia); John P. Mugler, III (Charlottesville, Virginia); Craig H. Meyer (Charlottesville, Virginia) |
| ABSTRACT | Training a neural network to correct motion-induced artifacts in magnetic resonance images includes acquiring motion-free magnetic resonance image (MRI) data of a target object and applying a spatial transformation matrix to the motion-free MRI data. Multiple frames of MRI data are produced having respective motion states. A Non-uniform Fast Fourier Transform (NUFFT) can be applied to generate respective k-space data sets corresponding to each of the multiple frames of MRI; the respective k-space data sets can be combined to produce a motion-corrupted k-space data set and an adjoint NUFFT can be applied to the motion-corrupted k-space data set. Updated frames of motion-corrupted MRI data can be formed. Using the updated frames of motion corrupted MRI data, a neural network can be trained that generates output frames of motion free MRI data; and the neural network can be saved. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733967 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) Original (OR) Class G01R 33/56509 (20130101) Image Data Processing or Generation, in General G06T 7/262 (20170101) G06T 2207/10088 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848073 | Zhi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida); The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida); The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Degui Zhi (Houston, Texas); Shaojie Zhang (Orlando, Florida); Ardalan Naseri (Houston, Texas); Ahsan Sanaullah (Orlando, Florida); Erwin Holzhauser (Orlando, Florida) |
| ABSTRACT | A system for indexing, updating, and search haplotypes for genetic genealogical discovery in genotype databases. The system includes a pool of genetic indexes, a haplotype ingestion engine, and a haplotype query engine. The haplotypes of a number of individuals in a genotype database are indexed by a pool of multiple panels, and each panel pool can be dynamically updated by the insertion or deletion of individual haplotypes. A genetic genealogical search of a query haplotype against the database is achieved by first projecting the query onto a subset of panels in the pool, then conducting long match queries over each panel, and finally aggregating the identified long matches into Identical-by-Descent segments, i.e., DNA matches, between the query and the haplotypes in the database. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 16/840145 |
| ART UNIT | 2165 — Data Bases & File Management |
| CURRENT CPC | Electric Digital Data Processing G06F 16/22 (20190101) G06F 16/24 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) Original (OR) Class G16B 20/20 (20190201) G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848183 | Wysocki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Vicki Wysocki (Columbus, Ohio); Joshua Gilbert (Columbus, Ohio); Alyssa Stiving (Columbus, Ohio) |
| ABSTRACT | Devices and methods for surface-induced dissociation (SID) are disclosed. In one aspect, a device for SID is disclosed which, in one embodiment includes a collision surface, a deflector configured to guide precursor ions from a pre-SID region to the collision surface to cause SID, and an ion carpet having applied electrical properties configured to guide product ions resulting from collision with the collision surface to a post-SID region. In another aspect, a method for SID is disclosed which, in one embodiment includes guiding, by a deflector, precursor ions from a pre-SID region to a collision surface to cause SID, and guiding, by an ion carpet having selected applied electrical properties, product ions resulting from collision with the collision surface to a post-SID region. |
| FILED | Thursday, December 26, 2019 |
| APPL NO | 16/727454 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/062 (20130101) H01J 49/0068 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11849283 | Garudadri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (La Jolla, California) |
| INVENTOR(S) | Harinath Garudadri (La Jolla, California); Ching-Hua Lee (La Jolla, California); Kuan-Lin Chen (La Jolla, California); Fred Harris (La Jolla, California); Bhaskar Rao (La Jolla, California) |
| ABSTRACT | A method and system or device such as a hearing aid are provided for processing audio signals. In accordance with the method, an audio signal is received and divided into a plurality of frequency sub-bands. For each of the frequency sub-band signals, the signal is further divided into overlapping temporal frames. Each of the temporal frames are windowed. Frequency warping is performed on each of the windowed frames. Overlap-and-add is performed on the frequency warped frames. The frequency warped sub-bands are combined into a full band to provide a frequency warped signal. |
| FILED | Wednesday, September 16, 2020 |
| APPL NO | 17/760842 |
| ART UNIT | 2651 — Videophones and Telephonic Communications |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 25/453 (20130101) Original (OR) Class H04R 2460/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11849642 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Xudong Wang (Middleton, Wisconsin); Jun Li (Madison, Wisconsin) |
| ABSTRACT | A piezoelectric artificial artery can be 3D printed to provide the real-time precise sensing of blood pressure and vessel motion patterns enabling early detection of partial occlusions. An electric-field assisted 3D printing method allows for rapid printing and simultaneously poled complex ferroelectric structures with high fidelity and good piezoelectric performance. The print material consists of ferroelectric potassium sodium niobate (KNN) particles embedded within a ferroelectric polyvinylidene fluoride (PVDF) polymer matrix. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 16/851400 |
| ART UNIT | 3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 9/08 (20130101) Electric solid-state devices not otherwise provided for H10N 30/057 (20230201) Original (OR) Class H10N 30/084 (20230201) H10N 30/092 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 11844714 | Blanck |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States As Represented By the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | The Government of the United States As Represented By the Secretary of the Army (Fort Detrick, Maryland) |
| INVENTOR(S) | Ryan V. Blanck (Gig Harbor, Washington) |
| ABSTRACT | An exoskeletal orthosis includes a proximal cuff including a hinge along an upper edge of the cuff; an ankle section/footplate; and at least one posterior strut connecting the proximal cuff to the ankle section and foot plate. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/462179 |
| ART UNIT | 3786 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/0125 (20130101) A61F 5/0127 (20130101) Original (OR) Class A61F 2005/0179 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844778 | Patel |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Rekha Patel (Irmo, South Carolina) |
| ABSTRACT | Methods for modification of abnormal protein interactions manifested as excessive PACT-mediated PKR activation within cells are described. Methods include administration of luteolin to cells that exhibit dysregulation in PACT-mediated PKR activation. Methods can decrease or prevent excessive non-viral PACT-mediated PKR activation in a cell as may occur due to expression by the cell of a mutant PACT protein. Methods can decrease an abnormal prolonged stress response as may occur in the absence of a stress-inducing activity or agent. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883227 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844911 | Williams et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Timothy K Williams (Winston-Salem, North Carolina); Lucas Paul Neff (Winton-Salem, North Carolina); James B Sampson (Davis, California) |
| ABSTRACT | A vascular access disassembling needle assembly is provided that enables rapid insertion of a guide wire into the needle and subsequent rapid removal of the access needle off the guide wire by facile disassembly of the needle. The disassembling needle assembly includes a needle portion wherein the needle breaks apart by splitting along at least one seam that extends from the proximal to the distal end to allow removal of the guide wire. Various mechanical features are described that can facilitate the separation of the needle body along at least one seam. Once one or more seams are separated, the needle body may be removed from the guide wire without the need to withdraw the needle along the length of the guide wire, which permits preloading of expanders and other medical devices onto the guidewire. |
| FILED | Tuesday, November 17, 2020 |
| APPL NO | 16/950134 |
| ART UNIT | 3783 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/34 (20130101) A61B 17/3403 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/065 (20130101) Original (OR) Class A61M 25/0169 (20130101) A61M 25/0668 (20130101) A61M 25/09041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845061 | Roper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Christopher S. Roper (Oak Park, California); Shanying Cui (Calabasas, California); Adam F. Gross (Santa Monica, California); Xin Guan (Brea, California) |
| ABSTRACT | Some variations provide an interspersed assembly of nanoparticles, the assembly comprising a first phase containing first nanoparticles and a second phase containing second nanoparticles, wherein the second phase is interspersed with the first phase, and wherein the first nanoparticles are compositionally different than the second nanoparticles. The interspersed assembly may be a semi-ordered assembly comprising discrete first-phase particles surrounded by a continuous second phase. Other variations provide a core-shell assembly of nanoparticles, the assembly comprising a first phase containing first nanoparticles and a second phase containing compositionally distinct second nanoparticles, wherein the second phase forms a shell surrounding a core of the first phase. The disclosed assemblies may have a volume from 1 μm3 to 1 mm3, a packing fraction from 20% to 100%, and an average relative surface roughness less than 5%, for example. Methods of making these assemblies are described, and many experimental examples are included. |
| FILED | Saturday, September 19, 2020 |
| APPL NO | 17/026223 |
| ART UNIT | 1763 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/3295 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 5/0242 (20130101) G02B 5/0284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845219 | Fedynyshyn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Theodore H. Fedynyshyn (Sudbury, Massachusetts); Jennifer A. Lewis (Cambridge, Massachusetts); Bradley P. Duncan (Andover, Massachusetts) |
| ABSTRACT | A 3-D printed device comprising one or more structures, the structures comprising a plurality of magnetically responsive particles and one or more diblock or triblock copolymers; the diblock or triblock copolymers having an A-B, A-B-A, or A-B-C block-type structure in which the A-blocks and C-blocks are an aromatic-based polymer or an acrylate-based polymer and the B-blocks are an aliphatic-based polymer. These 3-D printed devices may be formed using a method that comprises providing a magnetic ink composition; applying the magnetic ink composition to a substrate in a 3-D solvent cast printing process to form one or more structures; and drying the one or more structures formed from the magnetic ink composition. The dried structures can exhibit one or more regions of magnetic permeability greater than 1.3×10−6 H/m. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 16/864522 |
| ART UNIT | 1744 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 5/083 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Original (OR) Class B29C 64/209 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2023/06 (20130101) B29K 2023/12 (20130101) B29K 2025/06 (20130101) B29K 2105/251 (20130101) B29K 2995/0006 (20130101) B29K 2995/0008 (20130101) B29K 2995/0088 (20130101) B29K 2995/0093 (20130101) B29K 2995/0094 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/3456 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2033/0095 (20130101) Electrography; Electrophotography; Magnetography G03G 5/05 (20130101) G03G 5/07 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/49883 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/663 (20130101) H01M 10/653 (20150401) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/092 (20130101) H05K 2201/03 (20130101) H05K 2201/015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845543 | Jeong |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| INVENTOR(S) | Nathan Seongheon Jeong (Tuscaloosa, Alabama) |
| ABSTRACT | Systems and methods for enabling infinite wireless charging of unmanned aerial systems (UASs) are provided. A UAS detects sources of power and wirelessly charges itself by collecting ambient electromagnetic energy from a power infrastructure. A UAS in accordance with features and aspects described herein is autonomous, may always be wirelessly charged (e.g., with high induced voltage), and can make use of weak energy. Moreover, various charging techniques can be used, such as in-flight, trickle, perching, and/or parking. Dynamic flight is supported using multi-angle MIMO coils. Additionally or alternatively, faster charging can be achieved with a supercapacitor and slower charging can be achieved with a battery. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/124720 |
| ART UNIT | 2859 — Printing/Measuring and Testing |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Original (OR) Class Unmanned aerial vehicles [UAV]; equipment therefor B64U 50/34 (20230101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/345 (20130101) H02J 50/005 (20200101) H02J 50/10 (20160201) H02J 2207/50 (20200101) H02J 2310/44 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845656 | Becker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Carol A. Becker (Del Mar, California); Wayne E. Glad (Del Mar, California) |
| ABSTRACT | An apparatus and method generate oxygen gas from sodium percarbonate and water including seawater. The apparatus includes a chamber, a valve system, and an output port. The valve system controls combining a quantity of the sodium percarbonate, a quantity of the water, a quantity of potassium iodide, and optionally a quantity of sodium sulfate decahydrate. A chemical reaction between the sodium percarbonate and the water in the chamber generates oxygen gas, which is output at an output port from the chamber. The potassium iodide is a catalyst for the chemical reaction and optionally the sodium sulfate decahydrate is a temperature moderator for the chemical reaction. A ratio between the water and the sodium percarbonate is in a range of 2.5 to 8 by weight. A ratio of the potassium iodide per liter of the water yields a molarity in a range of 0.25 to 1.25. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/232741 |
| ART UNIT | 1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Devices, Apparatus or Methods for Life-saving A62B 7/08 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/0278 (20130101) B01J 2208/00752 (20130101) Non-metallic Elements; Compounds Thereof; C01B 13/0207 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845920 | Chou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David Benson Chou (Boston, Massachusetts); Liliana S. Teixeira Moreira Leijten (Maastricht, Netherlands); Arianna Rech (Leicestershire, United Kingdom); Richard Novak (Jamaica Plain, Massachusetts); Donald E. Ingber (Boston, Massachusetts); Yuka Milton (Cambridge, Massachusetts); Viktoras Frismantas (Roxburg Crossing, Massachusetts); Oren Levy (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure relates to a microfluidic devices and methods for culturing bone marrow cells. Aspects include methods of preparing microfluidic devices and culturing bone marrow cells with the microfluidic devices. In some aspects, a method includes providing a microfluidic device having an upper chamber, a lower chamber, and a porous membrane separating the upper chamber from the lower chamber. The method further includes seeding walls of the lower chamber and a bottom surface of the membrane with endothelial cells. The method further includes providing a matrix within the upper chamber. The matrix includes fibrin gel and bone marrow cells. The method further includes filling or perfusing the upper chamber with a media. |
| FILED | Monday, March 26, 2018 |
| APPL NO | 16/496997 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2300/12 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) C12M 29/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0669 (20130101) C12N 2501/40 (20130101) C12N 2501/999 (20130101) C12N 2502/28 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845927 | Semprini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon); North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon); North Carolina State University (Raleigh, North Carolina) |
| INVENTOR(S) | Lewis Semprini (Corvallis, Oregon); Mitchell Rasmussen (Corvallis, Oregon); Michael R. Hyman (Raleigh, North Carolina) |
| ABSTRACT | Certain disclosed embodiments concern a bioremediation composition comprising microbial cells, at least one co-metabolism substrate to induce selected enzyme production by the microbial cells, and a bead or gel encapsulating the microbial cells, such as bacterial or fungi cells, and the at least one co-metabolism substrate. For certain embodiments, the substrate is a slow release compound, such as an orthosilicate that hydrolyzes to produce an alcohol growth substrate. Embodiments of a method for using the composition to transform contaminants of concern also are disclosed. |
| FILED | Wednesday, November 20, 2019 |
| APPL NO | 16/689978 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/025 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/20 (20130101) C12N 9/0071 (20130101) C12N 11/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845950 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Cork, Ireland) |
| ABSTRACT | Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/894141 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845987 | Joung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Vikram Pattanayak (Wellesley, Massachusetts); Karl Petri (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions for performing highly sensitive in vitro assays to define substrate preferences and off-target sites of nucleic-acid binding, modifying, and cleaving agents. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 16/852257 |
| ART UNIT | 1675 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1058 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846008 | Chaput et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | United States of America as represented by Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Kevin J. Chaput (Beavercreek, Ohio); Oleg N. Senkov (Fairborn, Ohio); Todd M. Butler (Beavercreek, Ohio); Satish I Rao (Springboro, Ohio) |
| ABSTRACT | The present invention relates to Nb-based refractory alloys that are less expensive and less dense than current Nb-based refractory alloys, have better ductility than current Nb-based refractory alloys, yet which have similar or better high temperature strengths and oxidation resistance when compared to current Nb-based refractory alloys. Such Nb-based refractory alloys typically continue to be compatible with current coating systems for Nb-based refractory alloys. Such Nb-based refractory alloys are disclosed herein. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568414 |
| ART UNIT | 1784 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Alloys C22C 27/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846030 | Cox |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Stephen Charles Cox (San Diego, California) |
| ABSTRACT | A corrosion resistant bimetal includes a part and one or more sacrificial anodes. The part includes a metal component that is susceptible to corrosion. The sacrificial anodes consists of an attachment to the part through a metallic bond between the metal component and the sacrificial anode to form a crystalline solid that includes the sacrificial anode and the metal component of the part. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/411342 |
| ART UNIT | 1784 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 13/16 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 428/12736 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846191 | Hayes |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Special Aerospace Services, LLC (Boulder, Colorado) |
| ASSIGNEE(S) | Special Aerospace Services, LLC (Boulder, Colorado) |
| INVENTOR(S) | Christopher Hayes (Denver, Colorado) |
| ABSTRACT | Methods and systems for manipulating surface topology of additively manufactured fluid interacting structures, such as additively manufactured heat exchangers or airfoils, and associated additively manufactured articles, are disclosed. In one aspect, an article which interacts with a fluid is imparted with surface topology features which affect performance parameters related to the fluid flow. The topological features may be sequenced, combined, intermixed, and functionally varied in size and form to locally manipulate and co-optimize multiple performance parameters at each or selectable differential lengths along a flow path. The co-optimization method may uniquely prioritize selectable performance parameters at different points along the flow path to improve or enhance overall system performance. Topological features may include design features such as dimples, fins, boundary layer disruptors, and biomimicry surface textures, and manufacturing artefacts such as surface roughness and subsurface porosity distribution and morphology. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200022 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/38 (20130101) B29C 45/2612 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/14 (20130101) Original (OR) Class Jet-propulsion Plants F02K 9/60 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/31 (20130101) F05D 2300/514 (20130101) F05D 2300/516 (20130101) Electric Digital Data Processing G06F 30/15 (20200101) G06F 30/28 (20200101) G06F 2113/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846253 | Huang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aerojet Rocketdyne, Inc. (Sacramento, California) |
| ASSIGNEE(S) | AEROJET ROCKETDYNE, INC. (Canoga Park, California) |
| INVENTOR(S) | Yaping (Alan) Huang (Folsom, California) |
| ABSTRACT | An injector for a liquid rocket engine includes an array of injector elements. Each injector element includes a central passage and a plurality of peripheral transverse passages. The central passages are configured to provide axial injection flow and the peripheral transverse passages are configured to provide swirl injection flow about the axial injection flow. A portion of the injector elements are configured to provide the swirl injection flow in a clockwise direction and another portion of the injector elements are configured to provide the swirl injection flow in a counter-clockwise direction. The injector elements are arranged to form a plurality of circumferential rows. The injector elements of each individual circumferential row are either all of the clockwise direction or all of the counter-clockwise direction. At least one of the circumferential rows is of the clockwise direction and at least one of the circumferential rows is of the counter-clockwise direction. |
| FILED | Tuesday, October 30, 2018 |
| APPL NO | 17/286623 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Jet-propulsion Plants F02K 9/52 (20130101) Original (OR) Class F02K 9/60 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/40 (20130101) F05D 2250/37 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/34 (20130101) F23R 3/58 (20130101) F23R 3/343 (20130101) F23R 3/346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846392 | Mitchell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wavefront Research, Inc. (Northampton, Pennsylvania) |
| ASSIGNEE(S) | Wavefront Research, Inc. (Northampton, Pennsylvania) |
| INVENTOR(S) | Thomas A. Mitchell (Arrington, Tennessee); Jonas D. Corl (Bethlehem, Pennsylvania) |
| ABSTRACT | A system including an optical system having at least one refractive or reflective element, the optical system configured to substantially receive electromagnetic radiation emanating from a source, the optical system being located within a Dewar, a support structure, support structure being mechanically disposed between the optical system and a surface of the Dewar, the support structure having substantially low thermal conductance, a cold source; the cold source being located within the Dewar, a thermal link, the thermal link being mechanically disposed between the optical system and the cold source, the thermal link being substantially flexible and having substantially high thermal conductance. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/702677 |
| ART UNIT | 3763 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 3/085 (20130101) Original (OR) Class F17C 2250/07 (20130101) F17C 2250/038 (20130101) F17C 2250/0478 (20130101) F17C 2250/0491 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/18 (20130101) G01J 3/0291 (20130101) G01J 3/2823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846553 | Sotoudeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intelligent Fiber Optic Systems Corporation (San Jose, California) |
| ASSIGNEE(S) | Intelligent Fiber Optic Systems Corporation (San Jose, California) |
| INVENTOR(S) | Vahid Sotoudeh (Los Altos, California); Behzad Moslehi (Los Altos, California); Joshua Kuehn (Boulder Creek, California); Richard J. Black (Menlo Park, California) |
| ABSTRACT | A temperature correcting pressure gauge which has a diaphragm having at least one surface coupled to a source of pressure to be measured, the diaphragm first surface having a first FBG from a first optical fiber attached in an appropriately sensitive region of the diaphragm, a FBG from a second optical fiber attached to the opposite surface from the first FBG, the first and second FBGs reflecting or transmitting optical energy of decreasing or increasing wavelength, respectively, in response to an applied pressure. The first and second FBGs have nominal operating wavelength ranges that are adjacent to each other but are exclusive ranges and the FBGs also have closely matched pressure coefficients and temperature coefficients. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/523933 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/246 (20130101) G01L 11/025 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 6/0218 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846699 | Chieh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Jia-Chi Samuel Chieh (San Diego, California); Everly Yeo (San Diego, California); Max Kerber (San Diego, California); Randall B. Olsen (San Diego, California) |
| ABSTRACT | A need exists for a method to do monopulse tracking with a single beam phased array antenna. With a monopulse tracker antenna, the satellite, or moving target, will have a beacon signal that the tracker can acquire. The beacon signal may be a preamble in the transmitted signal from the satellite. The monopulse tracker antennas are scanned over the volume, minimizing the error signal. When the error signal is minimal, the antenna is pointed in the direction of the satellite or moving target. Because the tracker needs to know direction offsets in both azimuth and elevation planes, error signals from both planes are needed. The monopulse tracker antenna maintains a radio frequency link to the beacon signal, causing the antenna to lock in the direction of the satellite when the error signal is minimized to zero. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 16/855002 |
| ART UNIT | 3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/32 (20130101) G01S 7/282 (20130101) G01S 7/2925 (20130101) G01S 13/426 (20130101) G01S 13/4463 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 25/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846742 | Snyder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (Keyport, Washington) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Keyport, Washington) |
| INVENTOR(S) | Wendy E Snyder (Bremerton, Washington); Forrest N French (Poulsbo, Washington); Stephen John Leahu (Poulsbo, Washington) |
| ABSTRACT | Systems and methods are provided to detect and localize targeted objects buried in the seabed. A targeted area of the seabed may be scanned with a sub-bottom profiler based on predetermined parameters. A localization engine may model the sub-bottom profiler data using a Levenberg-Marquardt non-linear least squares determination. Distance measurements may be based on the modeled data, including a vertical range based on a slant range measured from the sub-bottom profiler to the closest points on the exterior of the targeted objects. The location of the targeted objects may be based on the measurements. In some embodiments, the sub-bottom profiler may be mounted on an unmanned underwater vehicle having thrusters to navigate the vehicle toward the targeted area to excavate and sidescan the targeted object. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/588191 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 1/3808 (20130101) G01V 1/3835 (20130101) Original (OR) Class G01V 2210/1297 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11847825 | Rowe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Anthony Rowe (Pittsburgh, Pennsylvania); Michael Farb (Pittsburgh, Pennsylvania); Ivan Liang (Pittsburgh, Pennsylvania); Edward Lu (Pittsburgh, Pennsylvania); Nuno Pereira (Pittsburgh, Pennsylvania); Eric Riebling (Pittsburgh, Pennsylvania) |
| ABSTRACT | Some embodiments of the present inventive concept provide for improved telepresence and other virtual sessions using localized projection of audible noises and/or dynamic adjustment of audio and/or video qualities based on spatial relationships between users. An XR telepresence platform can allow for immersive multi-user video conferencing from within a web browser or other medium. The platform can support spatial audio and/or user video. The platform can scale to hundreds or thousands of users concurrently in a single or multiple virtual environments. Disclosed herein are quality-of-service techniques for dynamically selecting or modifying audio and/or video traffic. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/685816 |
| ART UNIT | 2613 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 15/10 (20130101) G06T 19/006 (20130101) G06T 2219/024 (20130101) Image or Video Recognition or Understanding G06V 20/20 (20220101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 12/1827 (20130101) H04L 65/60 (20130101) H04L 65/403 (20130101) Stereophonic Systems H04S 7/303 (20130101) H04S 2400/11 (20130101) H04S 2400/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848174 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Kieran Wilson (Oviedo, Florida); Miles Bengtson (Broomfield, Colorado); Hanspeter Schaub (Golden, Colorado); Dalton Turpen (Boulder, Colorado) |
| ABSTRACT | Various embodiments of the present technology generally relate to devices and methods for generating and directing energetic electrons toward a target. More specifically, some embodiments relate to devices, systems, and methods for generating and directing energetic electrons based in the photoelectric effect and directing electric field-focused beams of the energetic electrons toward a target. Electron guns according to the present technology include one or more light sources to stimulate electron transmission, and a series of differentially charged stages to provide a hollow path allowing electrons generated by the photoelectric effect of the light irradiated on interior surfaces defining the path through the stages to travel to an exit of the electron gun. Each of the differentially charged stages have a different potential, thereby providing electrons having two or more different and tunable energy levels exiting as a beam from the electron gun. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186835 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/065 (20130101) H01J 37/305 (20130101) Original (OR) Class H01J 2237/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848396 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | NUTech Ventures, Inc. (Lincoln, Nebraska) |
| INVENTOR(S) | Jinsong Huang (Lincoln, Nebraska); Yehao Deng (Chapel Hill, North Carolina) |
| ABSTRACT | In an aspect, a method of forming a photoactive device comprises: providing a perovskite-surfactant solution, said perovskite-surfactant solution comprising a perovskite ink and a surfactant; and coating said perovskite-surfactant solution onto a receiving surface of a substrate thereby forming a layer of said photoactive device; wherein said layer comprises a perovskite material; and wherein an active area of said photoactive device is at least 1 cm2. |
| FILED | Friday, September 07, 2018 |
| APPL NO | 16/125400 |
| ART UNIT | 1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) Original (OR) Class H01L 31/032 (20130101) H01L 31/02167 (20130101) Organic electric solid-state devices H10K 30/00 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848457 | Lopotko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xentris Wireless LLC (Addison, Illinois) |
| ASSIGNEE(S) | Xentris Wireless, LLC (Addison, Illinois) |
| INVENTOR(S) | Mark Lopotko (Lisle, Illinois); Michael Joseph Culen (Glen Ellyn, Illinois); Norikiyo I. Honda (Elk Grove, Illinois); Cameron Eckert (Markle, Indiana) |
| ABSTRACT | A battery with a generally cuboid body with a top face. A cylindrical terminal extending from a center of the top face, a top of the cylindrical terminal provided with electrical contacts. A left tab and a right tab provided extending from the top face proximate a left end and a right end of the top face, respectively. A peripheral portion of each of the left and the right tabs forming a retaining groove extending from the top face; and an inward facing portion of the peripheral portion of each of the left and the right tabs facing the cylindrical terminal provided with an arc radius centered upon the center of the top face. The battery interconnectable with a range of electronic devices via a range of vectors and/or mechanics. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/141285 |
| ART UNIT | 1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/103 (20210101) H01M 50/184 (20210101) H01M 50/209 (20210101) Original (OR) Class H01M 50/247 (20210101) H01M 50/267 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848581 | Rentel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | X-wave Innovations, Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | X-Wave Innovations, Inc. (Gaithersburg, Maryland) |
| INVENTOR(S) | Carlos Rentel (Poolesville, Maryland); Hunter Jones (Silver Spring, Maryland) |
| ABSTRACT | The invention includes devices and methods used to regulate the power, voltage and/or current out of an individual energy storage module. A plurality of energy storage modules and/or individual interconnected energy storage modules can form an energy storage system when interconnected in series, parallel or series/parallel. The invention includes a method for storing and delivering energy, comprising providing an energy storage module for boosting the voltage of the energy storage component while delivering power to a load. |
| FILED | Saturday, June 13, 2020 |
| APPL NO | 16/900901 |
| ART UNIT | 2859 — Printing/Measuring and Testing |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/441 (20130101) H01M 2010/4271 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0013 (20130101) H02J 7/0014 (20130101) Original (OR) Class H02J 7/0024 (20130101) H02J 7/0063 (20130101) H02J 7/00714 (20200101) H02J 7/007182 (20200101) H02J 2207/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848676 | Whiteley |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | Synopsys, Inc. (Sunnyvale, California) |
| INVENTOR(S) | Stephen Whiteley (Sunnyvale, California) |
| ABSTRACT | The present disclosure relates to improved electronic structures for propagating logic states between superconducting digital logic gates using a three-junction interferometer in a receiver circuit to reduce reflecting signals that otherwise result in distortions in the signals being transmitted between the gates. Other improved electronic structures comprise passive transmission lines (PTLs) with transmission line matching circuitry that has previously been avoided. The matching circuitry minimizes generation and propagation of spurious pulses emitted by Josephson junctions used in the digital logic gates. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181869 |
| ART UNIT | 2845 — Electrical Circuits and Systems |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/035 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pulse Technique H03K 3/38 (20130101) Original (OR) Class H03K 17/92 (20130101) H03K 19/195 (20130101) H03K 19/1954 (20130101) Electric solid-state devices not otherwise provided for H10N 60/12 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11849065 | Balasubramaniyan et al. |
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| FUNDED BY |
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| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Vijay Balasubramaniyan (Atlanta, Georgia); Mustaque Ahamad (Atlanta, Georgia); Patrick Gerard Traynor (Decatur, Georgia); Michael Thomas Hunter (Atlanta, Georgia); Aamir Poonawalla (Atlanta, Georgia) |
| ABSTRACT | Various embodiments of the invention are detection systems and methods for detecting call provenance based on call audio. An exemplary embodiment of the detection system can comprise a characterization unit, a labeling unit, and an identification unit. The characterization unit can extract various characteristics of networks through which a call traversed, based on call audio. The labeling unit can be trained on prior call data and can identify one or more codecs used to encode the call, based on the call audio. The identification unit can utilize the characteristics of traversed networks and the identified codecs, and based on this information, the identification unit can provide a provenance fingerprint for the call. Based on the call provenance fingerprint, the detection system can identify, verify, or provide forensic information about a call audio source. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/338523 |
| ART UNIT | 2643 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/0829 (20130101) H04L 65/1076 (20130101) Telephonic Communication H04M 1/68 (20130101) H04M 3/2281 (20130101) Original (OR) Class H04M 7/0078 (20130101) H04M 2203/558 (20130101) H04M 2203/6027 (20130101) H04M 2203/6045 (20130101) Wireless Communication Networks H04W 12/02 (20130101) H04W 12/12 (20130101) H04W 12/63 (20210101) H04W 12/65 (20210101) H04W 24/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11849532 | Roper |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Christopher S Roper (Oak Park, California) |
| ABSTRACT | Some variations provide an atom vapor-density control system, the system comprising: a first electrode; a second electrode that is electrically isolated from the first electrode; an ion-conducting layer interposed between the first electrode and the second electrode, wherein the ion-conducting layer is in ionic communication with the second electrode; at least one atom reservoir in contact with the second electrode or with an additional electrode, wherein the atom reservoir is electrochemically configured to controllably supply or receive atoms; a heater in thermal communication with a heated region comprising the first electrode; and one or more thermal isolation structures configured to minimize heat loss out of the heated region into a cold region. Several exemplary system configurations are presented in the drawings. The disclosed atom vapor-density control systems are capable of controlling the vapor pressure of metal atoms (such as alkali atoms) at low electrical power input. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560371 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4071 (20130101) G01N 27/4074 (20130101) Time-interval Measuring G04F 5/14 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 3/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 11844362 | Gibbons et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SOUTH DAKOTA BOARD OF REGENTS, AS GOVERNING BOARD FOR SOUTH DAKOTA STATE UNIVERSITY (Pierre, South Dakota) |
| ASSIGNEE(S) | The South Dakota of Regents, As Governing Board for South Dakota State University (Pierre, South Dakota) |
| INVENTOR(S) | William Gibbons (Brookings, South Dakota); Michael Brown (Brookings, South Dakota) |
| ABSTRACT | The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/243315 |
| ART UNIT | 1791 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 1/14 (20130101) A23J 1/125 (20130101) Original (OR) Class A23J 1/148 (20130101) Fodder A23K 10/14 (20160501) A23K 10/38 (20160501) A23K 20/147 (20160501) A23K 40/20 (20160501) A23K 40/25 (20160501) A23K 50/80 (20160501) Technologies for Adaptation to Climate Change Y02A 40/818 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844604 | Gouma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Pelagia I. Gouma (Columbus, Ohio); Matthew Exline (Columbus, Ohio); Andrew Bowman (Milford Center, Ohio); Milutin Stanacevic (Smithtown, New York) |
| ABSTRACT | A method for evaluating for the presence of the COVID disease by detecting one or more biomarkers using a breathalyzer (138). The breath sample (2) taken from the subject (10) is passed over a sensor (140) which changes resistance in the presence of nitric oxide as a function of concentration. The resistance pattern of the subject (10) having the COVID disease will have a distinct shape, approximating the appearance of the small Greek letter omega (ω). Test results can be generated in less than a minute. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089251 |
| ART UNIT | 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/082 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/497 (20130101) G01N 2033/4977 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845115 | Campanella et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| ASSIGNEE(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| INVENTOR(S) | Andrew Campanella (Somerville, Massachusetts); Joseph G. Michels (New York, New York); Peter Quigley (Duxbury, Massachusetts); Ian Martin (Sharon, Massachusetts) |
| ABSTRACT | A control system for controlling extraction of landfill gas, comprising: at least one sensor configured to measure one or more characteristics of landfill gas; at least one flow control mechanism disposed in well piping and configured to control flow of the landfill gas through the well piping; and at least one processor configured to: obtain a measured concentration of a first gas in landfill gas; determine whether the measured concentration of the first gas is either less than a first threshold concentration or greater than a second threshold concentration; when it is determined that the measured concentration is less than the first threshold concentration, control the at least one flow control mechanism to reduce flow rate of landfill gas; and when it is determined that the concentration is greater than the second threshold concentration, control the at least one flow control mechanism to increase the flow rate of landfill gas. |
| FILED | Thursday, June 01, 2023 |
| APPL NO | 18/327638 |
| ART UNIT | 3679 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Disposal of Solid Waste B09B 1/006 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845143 | Brooks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Daniel R. Brooks (Rochester, New York); Jonathan D. Ellis (Tuscon, Arizona) |
| ABSTRACT | A pre-objective two-degree-of-freedom galvanometer scanning system including two galvo mirrors (111,112) with an optical relay (120) between the mirrors (111,112) and a microscope objective (130) with a curved image plane (140) is presented. The second galvo mirror (112) is located in the aperture stop before the objective. The optical system enables scanning in both directions over the full, curved field for creating custom refractive structures across the 6.5 mm optical zone of contact lenses using femtosecond micro-modification. |
| FILED | Friday, July 06, 2018 |
| APPL NO | 16/629199 |
| ART UNIT | 3761 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/082 (20151001) Original (OR) Class B23K 26/0624 (20151001) B23K 26/0648 (20130101) Optical Elements, Systems, or Apparatus G02B 13/0005 (20130101) G02B 13/0095 (20130101) G02B 26/101 (20130101) G02B 26/105 (20130101) G02B 27/0031 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845222 | Pearlson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Igneous IP Holdings, LLC (Wales, Wisconsin) |
| ASSIGNEE(S) | Igneous IP Holdings, LLC (Wales, Wisconsin) |
| INVENTOR(S) | Matthew N. Pearlson (Wales, Wisconsin) |
| ABSTRACT | An additive manufacturing technique uses digital mask-based illumination and a polar-based build environment for increased throughput. In one embodiment, the build environment comprises a rotating element having a surface. A coater is configured to deposit photopolymer material on the rotating element at a given flow rate. As the element rotates and the coater deposits the photopolymer material, a radiation source of an image scanning system projects an array of point sources (an image) onto the photopolymer material for an exposure time to cure a given layer. As the photopolymer material is deposited layer-upon-layer, and for each layer, a control system adjusts a relative position of the coater with respect to the surface, adjusts a speed of rotation of the rotating element, and maintains the flow rate and the exposure time constant. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749315 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/245 (20170801) Original (OR) Class B29C 64/277 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845660 | Uddi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| INVENTOR(S) | Mruthunjaya Uddi (Tuscaloosa, Alabama); Rajagopalan Varadarajan Ranganathan (Tuscaloosa, Alabama); Steven M. Fondriest (Granville, Ohio) |
| ABSTRACT | Chemical looping reform methods comprising heating an oxygen carrier in the presence of a catalyst and plasma radicals to react the oxygen carrier with a fuel to provide a reduced oxygen carrier; and contacting the reduced oxygen carrier with water or carbon dioxide to produce hydrogen or carbon monoxide, respectively, and regenerate the oxygen carrier. The chemical looping reform methods are carried out at low temperatures such as from 150° C. to 1000° C., preferably from 150° C. to 500° C. Catalyst used in the chemical looping reform methods include a sintered rare earth metal oxide oxygen carrier and perovskite. Methods of preparing the catalyst are also provided. |
| FILED | Monday, December 09, 2019 |
| APPL NO | 16/707607 |
| ART UNIT | 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/002 (20130101) B01J 23/10 (20130101) B01J 35/1014 (20130101) B01J 35/1066 (20130101) B01J 37/04 (20130101) B01J 37/08 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/40 (20130101) Original (OR) Class C01B 3/061 (20130101) C01B 2203/148 (20130101) C01B 2203/0244 (20130101) C01B 2203/0861 (20130101) C01B 2203/1058 (20130101) C01B 2203/1252 (20130101) C01B 2203/1264 (20130101) C01B 2203/1614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845773 | Swarts |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Central Michigan University (Mount Pleasant, Michigan) |
| ASSIGNEE(S) | Central Michigan University (Mount Pleasant, Michigan) |
| INVENTOR(S) | Benjamin M. Swarts (Mount Pleasant, Michigan) |
| ABSTRACT | Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068852 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 7/06 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/06 (20130101) G01N 33/582 (20130101) G01N 2333/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845862 | Coates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Bryce M. Lipinski (Ithaca, New York); Lilliana S. Morris (Wooster, Ohio) |
| ABSTRACT | Provided are strain-hardened polymers. The polymers may include a plurality of polyether units (e.g., isotactic polypropylene oxide units) and one or more crystalline domains. The strain-hardened polymers may have a higher initial engineering yield stress and/or enthalpy of fusion than native polymer (e.g., polypropylene oxide that has not been strain-hardened). The strain-hardened polymers may be made by catalytic methods using bimetallic catalysts. Also provided are uses of the strain-hardened polymers. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/182152 |
| ART UNIT | 1767 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 81/00 (20130101) Compositions of Macromolecular Compounds C08L 71/02 (20130101) Original (OR) Class C08L 75/04 (20130101) C08L 2207/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845997 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| INVENTOR(S) | Chang-Yu Wu (Gainesville, Florida); Xiao Jiang (Gainesville, Florida); Maohua Pan (Gainesville, Florida); John Lednicky (Gainesville, Florida); Alexandros Demetrios Theodore (Gainesville, Florida); Zhonghui Hugh Fan (Gainesville, Florida); Nima Afshar Mohajer (Baltimore, Maryland) |
| ABSTRACT | Described herein are bioaerosol detection systems and methods of use. In embodiments of bioaerosol detection systems and methods of use as described herein, systems and methods detect one or more coronaviruses and/or one or more influenza strains. In embodiments, coronaviruses according to systems and methods as described herein are SARS-CoV-2 coronavirus. In embodiments, influenza strains and/or particles according to the present disclosure are H1N1 influenza. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/104525 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/11 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846032 | Lichtenberger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| INVENTOR(S) | Dennis Lichtenberger (Tucson, Arizona); Richard S. Glass (Tucson, Arizona); Dong-Chul Pyun (Tucson, Arizona); William Brezinski (Tucson, Arizona); Kayla Clary (Tucson, Arizona); Metin Karayilan (Tucson, Arizona) |
| ABSTRACT | Catalyst systems employing inexpensive and readily-available protic co-catalysts to increase a proton reduction rate in a hydrogen evolution reaction (HER) are described herein. The protic co-catalysts function to increase the rate without being consumed in the process of water splitting to hydrogen and oxygen. They may simultaneously serve to stabilize the pH of the water and be the electrolyte to carry the current for the electrolytic splitting of water. The protic co-catalysts also decrease the overpotential energy requirement for the process of water splitting. These protic co-catalysts can be used with both heterogeneous and homogenous catalysts, as well as assist photocatalysis and other processes for the reduction of protons. |
| FILED | Tuesday, December 11, 2018 |
| APPL NO | 16/771597 |
| ART UNIT | 1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) Original (OR) Class C25B 9/17 (20210101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846226 | Masoudi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EMISSOL LLC (Mill Creek, Washington) |
| ASSIGNEE(S) | Emissol, LLC (Mill Creek, Washington) |
| INVENTOR(S) | Mansour Masoudi (Mill Creek, Washington); Jacob Roy Hensel (Mill Creek, Washington); Edward Benjamin Tegeler, IV (Mill Creek, Washington); Nikolai Alex Poliakov (Mill Creek, Washington) |
| ABSTRACT | A segmented, heated urea mixer and an exhaust system to control NOx emission from combustion engines comprising a plurality of elements, at least one element independently heatable by an external power source to a temperature above a temperature of another element. A method of using the exhaust gas mixer and an exhaust gas mixer system further comprising a controller is also disclosed. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/764124 |
| ART UNIT | 3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines F01N 3/2013 (20130101) F01N 3/2066 (20130101) F01N 3/2892 (20130101) Original (OR) Class F01N 2240/16 (20130101) F01N 2240/20 (20130101) F01N 2240/25 (20130101) F01N 2570/14 (20130101) F01N 2610/02 (20130101) F01N 2610/102 (20130101) F01N 2610/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846611 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NUTECH VENTURES (Lincoln, Nebraska); UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | NUTECH VENTURES (Lincoln, Nebraska); UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Ruiguo Yang (Lincoln, Nebraska); Nikolay V. Lavrik (Knoxville, Tennessee); Amir Monemian Esfahani (Lincoln, Nebraska); Jordan Daniel Rosenbohm (Lincoln, Nebraska); Bahareh Tajvidi Safa (Lincoln, Nebraska); Grayson Minnick (Lincoln, Nebraska) |
| ABSTRACT | A method of measuring a stress-strain curve in a cell-cell adhesion interface, the method including: providing a structure including a first movable island supported by a first beam, a second movable island supported by a second beam, and a gap therebetween connected by a pair of cells forming a junction, the pair of cells comprising a cell-cell adhesion interface having an initial length defined by a distance between nuclei of the pair of cells; moving the second movable island with a defined displacement; determining a displacement of the first movable island based on moving the second movable island; calculating a difference between the displacement of the first movable island and the defined displacement of the second movable island based on moving the second movable island; determining an applied strain in the cell-cell adhesion interface between the pair of cells based on the difference divided by the initial length of the cell-cell adhesion interface; calculating a force between the cell-cell adhesion interface of the pair of cells based on the displacement of the first movable island; calculating a stress in the cell-cell adhesion interface between the pair of cells based on the force; and determining the stress-strain curve of the cell-cell adhesion interface between the pair of cells by plotting the calculated stress against the applied strain. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473090 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/06 (20130101) G01N 3/08 (20130101) Original (OR) Class G01N 19/04 (20130101) G01N 2203/0089 (20130101) G01N 2203/0286 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/26 (20130101) G01Q 60/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846621 | Lebedev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trace-Ability, Inc. (Van Nuys, California) |
| ASSIGNEE(S) | Trace-Ability, Inc. (Van Nuys, California) |
| INVENTOR(S) | Artem Y. Lebedev (Santa Monica, California); Arkadij M. Elizarov (Woodland Hills, California) |
| ABSTRACT | A method of determining a radioactivity characteristic of a radioactive sample comprises positioning the radioactive sample on a plate, positioning the plate containing the radioactive sample in an optical plate reader, obtaining luminescence data via the optical plate reader based on light emitted from the plate containing the radioactive sample, and determining a radioactivity characteristic of the radioactive sample based on the luminescence data. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085296 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/037 (20130101) Apparatus for Enzymology or Microbiology; C12M 41/36 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/51 (20130101) G01N 21/78 (20130101) G01N 21/82 (20130101) G01N 21/253 (20130101) G01N 33/15 (20130101) Original (OR) Class G01N 2021/752 (20130101) G01N 2033/0093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846630 | Su et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | Northeastern University (Boston, Massachusetts) |
| INVENTOR(S) | Ming Su (Newton, Massachusetts); Qingxuan Li (Boston, Massachusetts); Liyuan Ma (Newton, Massachusetts); Sidi A. Bencherif (Boston, Massachusetts); Thibault Colombani (Boston, Massachusetts) |
| ABSTRACT | Disclosed is a technology for assaying individual cells, in which the identity of each individual cell in an ordered array is determined from coordinates assigned to it, and can be readout at high throughput with microscope. The method is able to test responses of millions of identical cells in multiple chemical and physical processes with superior statistics power to facilitate deep data mining. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 16/811785 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 41/36 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0693 (20130101) C12N 13/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6408 (20130101) G01N 21/6428 (20130101) G01N 27/02 (20130101) G01N 33/505 (20130101) Original (OR) Class G01N 33/5011 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846828 | Close et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of The University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Laird M. Close (Tucson, Arizona); Maggie Y. Kautz (Tucson, Arizona) |
| ABSTRACT | A stabilizing locking clamp for a kinematic optical mount includes a clamp plate configured for optical access and a plurality of clamp actuators affixed to the clamp plate. The clamp actuators are positioned such that each clamp actuator exerts a force on a front plate of the kinematic optical mount in a push-push configuration. A stabilizing kinematic optical mount includes a kinematic optical mount and a plurality of clamp arms, each clamp arm including a clamp actuator positioned to exert a force on a front plate of the kinematic optical mount in a push-push configuration. The stabilizing locking clamp and stabilizing kinematic optical mount reduce temperature-dependent and vibration-induced changes in pitch and yaw, thereby improving pointing stability for optical setups that rely on critical beam alignment. |
| FILED | Friday, February 08, 2019 |
| APPL NO | 16/969547 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 2/065 (20130101) Optical Elements, Systems, or Apparatus G02B 7/181 (20130101) G02B 7/1825 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848183 | Wysocki et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Vicki Wysocki (Columbus, Ohio); Joshua Gilbert (Columbus, Ohio); Alyssa Stiving (Columbus, Ohio) |
| ABSTRACT | Devices and methods for surface-induced dissociation (SID) are disclosed. In one aspect, a device for SID is disclosed which, in one embodiment includes a collision surface, a deflector configured to guide precursor ions from a pre-SID region to the collision surface to cause SID, and an ion carpet having applied electrical properties configured to guide product ions resulting from collision with the collision surface to a post-SID region. In another aspect, a method for SID is disclosed which, in one embodiment includes guiding, by a deflector, precursor ions from a pre-SID region to a collision surface to cause SID, and guiding, by an ion carpet having selected applied electrical properties, product ions resulting from collision with the collision surface to a post-SID region. |
| FILED | Thursday, December 26, 2019 |
| APPL NO | 16/727454 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/062 (20130101) H01J 49/0068 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848417 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xiaowei Li (Philadelphia, Pennsylvania); Yongwei Zheng (Philadelphia, Pennsylvania); Christopher Li (Bala Cynwyd, Pennsylvania) |
| ASSIGNEE(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Xiaowei Li (Philadelphia, Pennsylvania); Yongwei Zheng (Philadelphia, Pennsylvania); Christopher Li (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | Ionic liquid N-methyl-N-propyl-pyrrolidinium bis(fluorosulfonyl)imide (Pyr13FSI) was introduced into a hybrid network to obtain a series of gel polymer electrolytes (GPEs). Mechanical and electrochemical properties of the GPEs were tuned through controlling the network structure and ionic liquid contents, and ionic conductivity higher than 1 mS cm−1 at room temperature was achieved. The newly developed GPEs are flame-retardant and show excellent thermal and electrochemical stability as well as ultra-stability with lithium metal anode. Symmetrical lithium cells with the GPEs exhibit a stable cycling over 6800 h at a current density of 0.1 mA cm−2 and stable lithium stripping-plating at 1 mA cm−2, the highest current density reported for ionic liquid-based GPEs. Moreover, Li/LiFePO4 batteries with the obtained GPEs exhibit desirable cycling stability and rate performance over a wide temperature range from 0° C. to 90° C. |
| FILED | Sunday, May 02, 2021 |
| APPL NO | 17/246681 |
| ART UNIT | 1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/336 (20130101) C08G 77/045 (20130101) C08G 2220/00 (20130101) C08G 2650/20 (20130101) C08G 2650/50 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 10/0567 (20130101) H01M 10/4235 (20130101) H01M 2004/027 (20130101) H01M 2300/0025 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US RE49763 | Le et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lion Semiconductor Inc. (Austin, Texas) |
| ASSIGNEE(S) | Lion Semiconductor Inc. (Austin, Texas) |
| INVENTOR(S) | Hanh-Phuc Le (San Diego, California); John Crossley (Oakland, California); Alberto Alessandro Angelo Puggelli (Cupertino, California); Wonyoung Kim (Los Altos, California) |
| ABSTRACT | A feedback system that can control hybrid regulator topologies that have multiple converters or regulators connected in series is described. The hybrid regulator can include at least two regulators: a switched inductor regulator and a switched-capacitor regulator. The feedback system can simplify feedback design for the hybrid regulator that can include multiple converter stages and can control the feedback to improve the efficiency of a hybrid regulator. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/407103 |
| ART UNIT | 3992 — Central Reexamination Unit (Electrical) |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/007 (20210501) H02M 3/07 (20130101) H02M 3/155 (20130101) H02M 3/158 (20130101) Original (OR) Class H02M 3/1584 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 11845058 | Long et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Jeffrey R. Long (Oakland, California); Thomas M. McDonald (Berkeley, California) |
| ABSTRACT | A system and method for acid gas separations using porous frameworks of metal atoms coordinatively bound to polytopic linkers that are functionalized with basic nitrogen ligands that expose nitrogen atoms to the pore volumes forming adsorption sites. Adjacent basic nitrogen ligands on the metal-organic framework can form an ammonium from one ligand and a carbamate from the other. The formation of one ammonium carbamate pair influences the formation of ammonium carbamate on adjacent adsorption sites. Adsorption of acid gas at the adsorption sites form covalently linked aggregates of more than one ammonium carbamate ion pair. The acid gas adsorption isotherm can be tuned to match the step position with the partial pressure of acid gas in the gas mixture stream through manipulation of the metal-ligand bond strength by selection of the ligand, metal and polytopic linker materials. |
| FILED | Thursday, June 25, 2020 |
| APPL NO | 16/912137 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 53/40 (20130101) B01D 53/62 (20130101) B01D 2253/204 (20130101) B01D 2257/504 (20130101) B01D 2258/0283 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/3085 (20130101) B01J 20/3425 (20130101) B01J 20/3483 (20130101) B01J 20/28057 (20130101) Capture, Storage, Sequestration or Disposal of Greenhouse Gases [GHG] Y02C 20/40 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845132 | van Rooyen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Isabella J. van Rooyen (Idaho Falls, Idaho); Piyush Sabharwall (Idaho Falls, Idaho) |
| ABSTRACT | A method of forming at least a component of a heat exchanger comprises introducing a feed material comprising a first portion including a matrix material and a second portion including a sacrificial material on a surface of a substrate, exposing at least the first portion to energy to form bonds between particles of the matrix material and form a first thickness of a structure, introducing additional feed material comprising the first portion over the first thickness of the structure, exposing the additional feed material to energy to form a second thickness of the structure, and removing the sacrificial material from the structure to form at least one channel in the structure. Related heat exchangers and components, and related methods are disclosed. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/806916 |
| ART UNIT | 3726 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 5/10 (20130101) Original (OR) Class B22F 10/22 (20210101) B22F 10/25 (20210101) B22F 10/28 (20210101) B22F 10/43 (20210101) B22F 10/62 (20210101) B22F 10/64 (20210101) B22F 10/66 (20210101) B22F 12/53 (20210101) Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/26 (20130101) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 21/04 (20130101) F28F 21/081 (20130101) F28F 2255/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845144 | Matthews |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Manyalibo Joseph Matthews (Livermore, California) |
| ABSTRACT | A nanofluid laser entrainment additive manufacturing apparatus, system and method including a substrate, a dilute nanofluid of inert gas suspended nanoparticles on the substrate, a focused energy beam that irradiates the nanoparticles to selectively melt the nanoparticles, and a raster system that raster scans the focused energy beam across the inert gas suspended nanoparticles to create predetermined shapes by additive manufacturing. |
| FILED | Friday, March 22, 2019 |
| APPL NO | 16/971027 |
| ART UNIT | 2898 — Semiconductors/Memory |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 10/28 (20210101) B22F 10/32 (20210101) B22F 10/73 (20210101) B22F 12/38 (20210101) B22F 12/41 (20210101) B22F 12/49 (20210101) B22F 12/70 (20210101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/34 (20130101) B23K 26/354 (20151001) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845682 | Kostecki et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | the Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Robert Kostecki (Lafayette, California); Ravi S. Prasher (Danville, California); Akanksha K. Menon (Berkeley, California); Andrew Z. Haddad (Berkeley, California); Jeffrey J. Urban (Emeryville, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to water desalination. In one aspect, a method includes generating a diluted draw solution using forward osmosis. Wastewater is on a first side of an osmotic membrane and a draw solution is on a second side of the osmotic membrane. The draw solution comprises a mixture of water and an ionic liquid. Water in the wastewater diffuses across the osmotic membrane to the draw solution to form the diluted draw solution. The diluted draw solution is heated using a photonic heater to a temperature above a lower critical solution temperature (LCST) of the ionic liquid to phase separate the diluted draw solution into the ionic liquid and treated water. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370379 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Separation B01D 61/04 (20130101) B01D 61/005 (20130101) B01D 61/027 (20130101) B01D 61/58 (20130101) B01D 2311/04 (20130101) B01D 2311/06 (20130101) B01D 2311/2649 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/001 (20130101) C02F 1/02 (20130101) C02F 1/442 (20130101) C02F 1/445 (20130101) C02F 9/00 (20130101) Original (OR) Class C02F 2103/10 (20130101) C02F 2301/046 (20130101) C02F 2303/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845765 | Orendorff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Christopher Orendorff (Albuquerque, New Mexico); Ganesan Nagasubramanian (Albuquerque, New Mexico); Kyle R. Fenton (Albuquerque, New Mexico); David Ingersoll (Albuquerque, New Mexico); Harry Pratt (Albuquerque, New Mexico); Chad Staiger (Albuquerque, New Mexico); Travis Mark Anderson (Albuquerque, New Mexico) |
| ABSTRACT | A method for synthesizing a purified lithium (Li)+ anion binding agent (ABA-F)− salt and the corresponding Li+(ABA-F)− are disclosed. The method includes dissolving a boron-based acid in a polar solvent to form a solution. The solution is refluxed to form an anion binding agent. A stoichiometric amount of a small fluorinated salt, such as LiF, is added to the anion binding agent to form a mixture. The mixture is subsequently crystallized to obtain a substantially pure Li+(ABA-F)− salt. Example purified Li+(ABA-F)− salts include Ox-Li+(ABA-F), m-Li+(ABA-F), and BF3—Li+(ABA-F)−. These purified Li+(ABA-F)− salts provide the benefits of increased battery thermal safety without loss of electrochemical performance. |
| FILED | Tuesday, October 27, 2020 |
| APPL NO | 17/080935 |
| ART UNIT | 3763 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Separation B01D 9/005 (20130101) B01D 9/0022 (20130101) B01D 9/0045 (20130101) B01D 9/0059 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/61 (20150401) H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 10/4235 (20130101) H01M 2300/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845870 | Mitkova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOISE STATE UNIVERSITY (Boise, Idaho) |
| ASSIGNEE(S) | Boise State University (Boise, Idaho) |
| INVENTOR(S) | Maria Mitkova (Boise, Idaho); Al-Amin Ahmed Simon (Boise, Idaho); Shah Mohammad Rahmot Ullah (Milpitas, California); Bahareh Badamchi (Boise, Idaho); Harish Subbaraman (Boise, Idaho) |
| ABSTRACT | A device formation method may include printing a chalcogenide glass ink onto a surface to form a chalcogenide glass layer, where the chalcogenide glass ink comprises chalcogenide glass and a fluid medium. The method may further include sintering the chalcogenide glass layer at a first temperature for a first duration. The method may also include annealing the chalcogenide glass layer at a second temperature for a second duration. A device may include a substrate and a printed chalcogenide glass layer on the substrate, where the printed chalcogenide glass layer includes annealed chalcogenide glass, and where the printed chalcogenide glass layer is free from cracks. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/111353 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/10 (20200101) B33Y 70/10 (20200101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Manufacture, Shaping, or Supplementary Processes C03B 5/2252 (20130101) C03B 19/12 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 1/006 (20130101) C03C 3/321 (20130101) C03C 21/005 (20130101) C03C 2203/50 (20130101) C03C 2204/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/03 (20130101) Original (OR) Class C09D 11/38 (20130101) Static Stores G11C 13/0011 (20130101) G11C 2213/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845940 | Geiselman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY AND ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Gina Marie Geiselman (Alameda, California); James Kirby (Berkeley, California); Taek Soon Lee (Berkeley, California); John M. Gladden (Alameda, California); Blake A. Simmons (San Francisco, California) |
| ABSTRACT | The present invention provides for a genetically modified fungal host cell capable of producing prespatane and/or epi-isozizaene comprising prespatane synthase (PPS) and/or epi-isozizaene synthase (EIZS). |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/187697 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/04 (20130101) C10L 2200/043 (20130101) C10L 2270/04 (20130101) C10L 2290/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 9/88 (20130101) C12N 15/815 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/007 (20130101) Enzymes C12Y 402/03037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846021 | Mane et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Anil U. Mane (Naperville, Illinois); Jeffrey W. Elam (Elmhurst, Illinois); Seth B. Darling (Chicago, Illinois); Nestor J. Zaluzec (Bolingbrook, Illinois); Alex B. Martinson (Naperville, Illinois) |
| ABSTRACT | The sequential infiltration synthesis (SIS) and Atomic Layer Deposition (ALD) of metal and/or metal oxides on personal medical equipment (PPE). The deposited metal and/or metal oxides imbues antimicrobial properties to the PPE. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/039969 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) A01N 59/16 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/18 (20130101) A61L 2101/02 (20200801) A61L 2101/06 (20200801) A61L 2101/24 (20200801) A61L 2101/30 (20200801) A61L 2202/26 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/40 (20130101) C23C 16/0272 (20130101) C23C 16/45527 (20130101) Original (OR) Class C23C 16/45555 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846024 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Hongping Zhao (Columbus, Ohio); Zhaoying Chen (Columbus, Ohio); Yuxuan Zhang (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are laser-assisted metal-organic chemical vapor deposition devices and methods of use thereof for suppressing background carbon incorporation. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/201815 |
| ART UNIT | 2899 — Semiconductors/Memory |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/46 (20130101) C23C 16/483 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/67023 (20130101) H01L 21/67115 (20130101) H01L 21/67207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846160 | Su et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Jiann-Cherng Su (Albuquerque, New Mexico); Somuri V. Prasad (Albuquerque, New Mexico); Rand Garfield (Corrales, New Mexico) |
| ABSTRACT | A coating architecture is disclosed that includes a substrate having a surface finish Ra of 0.3μ or finer, an intermediate layer overlying and in contact with the substrate; and a solid lubricant layer overlying and in contact with the intermediate layer. The test results of applying the coating architecture to a reciprocating hammer drill utilizing the coating is also disclosed. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/485749 |
| ART UNIT | 3731 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 9/007 (20130101) B32B 15/18 (20130101) B32B 2311/18 (20130101) B32B 2313/04 (20130101) B32B 2315/02 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 4/003 (20130101) Original (OR) Class E21B 4/14 (20130101) E21B 17/1007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846263 | Medina et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hector Eduardo Medina (Forest, Virginia); Thomas V. Eldredge (Forest, Virginia) |
| ASSIGNEE(S) | Hector Eduardo Medina (Forest, Virginia); Thomas Vance Eldredge (Forest, Virginia) |
| INVENTOR(S) | Hector Eduardo Medina (Forest, Virginia); Thomas V. Eldredge (Forest, Virginia) |
| ABSTRACT | A pumped storage hydroelectric system may include a reservoir system including an upper reservoir system and a lower reservoir system. At least one of the upper reservoir system and the lower reservoir system may include a modular reservoir arrangement. A penstock may be coupled with the upper reservoir system. A pump/turbine may be coupled with the penstock and with the lower reservoir system. The pump/turbine may be configured to receive water flowing from the upper reservoir system to the lower reservoir system for generating electrical power, and to pump water from the lower reservoir system to the upper reservoir system for storing energy. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/671146 |
| ART UNIT | 2834 — Electrical Circuits and Systems |
| CURRENT CPC | Machines or Engines for Liquids F03B 13/06 (20130101) Original (OR) Class Wind Motors F03D 9/14 (20160501) F03D 9/28 (20160501) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/40 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/12 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846451 | Ho et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); CSIRO (Canberra, Australia) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Commonwealth Scientific and Industrial Research Organisation (Acton, Australia) |
| INVENTOR(S) | Clifford K. Ho (Albuquerque, New Mexico); Jin-Soo Kim (Corlette, Australia); Apurv Kumar (Palmerston, Australia) |
| ABSTRACT | The present disclosure is directed to multi-stage falling particle receivers and methods of falling particle heating. As the particles fall through the receiver, the particles are periodically collected and released by flow retarding devices. The periodic catch-and-release of the particles falling through the receiver reduces particle flow dispersion, increases particle opacity and solar absorption, and reduces erosion and damage to surfaces caused by direct particle impingement. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/158745 |
| ART UNIT | RD00 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Solar Heat Collectors; Solar Heat Systems F24S 25/40 (20180501) F24S 30/00 (20180501) F24S 60/00 (20180501) F24S 70/16 (20180501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846611 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NUTECH VENTURES (Lincoln, Nebraska); UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | NUTECH VENTURES (Lincoln, Nebraska); UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Ruiguo Yang (Lincoln, Nebraska); Nikolay V. Lavrik (Knoxville, Tennessee); Amir Monemian Esfahani (Lincoln, Nebraska); Jordan Daniel Rosenbohm (Lincoln, Nebraska); Bahareh Tajvidi Safa (Lincoln, Nebraska); Grayson Minnick (Lincoln, Nebraska) |
| ABSTRACT | A method of measuring a stress-strain curve in a cell-cell adhesion interface, the method including: providing a structure including a first movable island supported by a first beam, a second movable island supported by a second beam, and a gap therebetween connected by a pair of cells forming a junction, the pair of cells comprising a cell-cell adhesion interface having an initial length defined by a distance between nuclei of the pair of cells; moving the second movable island with a defined displacement; determining a displacement of the first movable island based on moving the second movable island; calculating a difference between the displacement of the first movable island and the defined displacement of the second movable island based on moving the second movable island; determining an applied strain in the cell-cell adhesion interface between the pair of cells based on the difference divided by the initial length of the cell-cell adhesion interface; calculating a force between the cell-cell adhesion interface of the pair of cells based on the displacement of the first movable island; calculating a stress in the cell-cell adhesion interface between the pair of cells based on the force; and determining the stress-strain curve of the cell-cell adhesion interface between the pair of cells by plotting the calculated stress against the applied strain. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473090 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/06 (20130101) G01N 3/08 (20130101) Original (OR) Class G01N 19/04 (20130101) G01N 2203/0089 (20130101) G01N 2203/0286 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/26 (20130101) G01Q 60/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846626 | Turick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Savannah River Nuclear Solutions, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | Battelle Savannah River Alliance, LLC (Aiken, South Carolina) |
| INVENTOR(S) | Charles E Turick (Aiken, South Carolina); Charles E Milliken (Evans, Georgia); Hector Colon-Mercado (Aiken, South Carolina); Scott D Greenway (Aiken, South Carolina); Ariane L Martin (Sitka, Alaska) |
| ABSTRACT | The present invention is directed to a method of detecting microbial stress. The method comprises the following: providing an electrochemical device having at least one reference electrode and one working electrode wherein the electrochemical device also contains a fermenting microbe, setting an electrochemical potential, providing a source of electrical energy electrically connected to the at least one working electrode, detecting a transfer of electrons from the working electrode to the fermenting microbe, wherein the detection is an indication of microbial stress, and providing a remedial action in response to the indication of microbial stress. |
| FILED | Thursday, November 09, 2017 |
| APPL NO | 15/808244 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/301 (20130101) G01N 27/327 (20130101) G01N 33/4833 (20130101) Original (OR) Class G01N 2333/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11849569 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Toyota Motor Engineering and Manufacturing North America, Inc (Plano, Texas) |
| ASSIGNEE(S) | Toyota Motor Engineering and Manufacturing North America, Inc. (Plano, Texas) |
| INVENTOR(S) | Feng Zhou (Ann Arbor, Michigan); Ercan M. Dede (Ann Arbor, Michigan); Hiroshi Ukegawa (South Lyon, Michigan) |
| ABSTRACT | A configurable, double sided, manifold micro-channel cold plate includes a one or more manifold micro-channel cold plate cells. Each cold plate cell includes a manifold body, a manifold insert, a plurality of heat sinks, and a plurality of longitudinal openings configured for fluidic communication with the fluid channels. The manifold body has fluid channels to permit flow of a fluid coolant. The manifold insert has a plurality of manifold insert fluid channels, and is configured for receipt in the one of the modular body recesses. The heat sinks are configured for receipt in the modular body recesses, and include an impingement surface configured for fluidic communication with the manifold insert fluid channels, and a heat transfer surface for thermal communication with one or more heat generating devices. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085708 |
| ART UNIT | 2835 — Electrical Circuits and Systems |
| CURRENT CPC | Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 3/12 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20254 (20130101) H05K 7/20927 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 11844347 | Cope et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Accelerated Ag Technologies, LLC (Ankeny, Iowa) |
| ASSIGNEE(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| INVENTOR(S) | Jason Cope (Ankeny, Iowa); George Singletary (Ankeny, Iowa); Todd Krone (Des Moines, Iowa); Sara Katherine Etter (Bondurant, Iowa) |
| ABSTRACT | Described are methods of grain production with field conditioned pollen. A method of the present invention includes growing one or more designated female plants that include both female and male components, collecting fresh pollen from designated male plants from a different genetic background, and subjecting the fresh pollen to field conditions, which may regulate pollen moisture content. The field conditioning conditions may include a relative humidity ranging from about 50% to about 100%, a temperature ranging from about −10-10° C., and an air pressure ranging from about 15 kPa to about 150 kPa. These conditions may result in pollen having a moisture content of about 40% to about 58%. The one or more designated female plants are intentionally cross-pollinated with the field conditioned pollen and then grown to maturity such that the grain may be harvested therefrom. Also provided is a method of preventing undesirable pollination in grain production. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458944 |
| ART UNIT | 1662 — Plants |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844348 | Cope et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| ASSIGNEE(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| INVENTOR(S) | Jason Cope (Ankeny, Iowa); George Singletary (Ankeny, Iowa); Todd Krone (Des Moines, Iowa); Sara Katherine Etter (Bondurant, Iowa) |
| ABSTRACT | Described are methods of preserving cereal crop pollen and/or anthers. A method of the present invention includes collecting fresh pollen and/or anthers and introducing the pollen and/or anthers to field conditioning conditions which regulate pollen moisture content. The field conditioning conditions may include a an air flow at a humidity ranging from 0% to about 99% and a temperature ranging from about −10-10° C. The field conditioning conditions may further include a flow of one or more continuously refreshed, selected gases. The field conditioning conditions may dehydrate the pollen to achieve a pollen moisture content of about 15% to about 35%. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/686939 |
| ART UNIT | 1662 — Plants |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845115 | Campanella et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| ASSIGNEE(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| INVENTOR(S) | Andrew Campanella (Somerville, Massachusetts); Joseph G. Michels (New York, New York); Peter Quigley (Duxbury, Massachusetts); Ian Martin (Sharon, Massachusetts) |
| ABSTRACT | A control system for controlling extraction of landfill gas, comprising: at least one sensor configured to measure one or more characteristics of landfill gas; at least one flow control mechanism disposed in well piping and configured to control flow of the landfill gas through the well piping; and at least one processor configured to: obtain a measured concentration of a first gas in landfill gas; determine whether the measured concentration of the first gas is either less than a first threshold concentration or greater than a second threshold concentration; when it is determined that the measured concentration is less than the first threshold concentration, control the at least one flow control mechanism to reduce flow rate of landfill gas; and when it is determined that the concentration is greater than the second threshold concentration, control the at least one flow control mechanism to increase the flow rate of landfill gas. |
| FILED | Thursday, June 01, 2023 |
| APPL NO | 18/327638 |
| ART UNIT | 3679 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Disposal of Solid Waste B09B 1/006 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11846553 | Sotoudeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intelligent Fiber Optic Systems Corporation (San Jose, California) |
| ASSIGNEE(S) | Intelligent Fiber Optic Systems Corporation (San Jose, California) |
| INVENTOR(S) | Vahid Sotoudeh (Los Altos, California); Behzad Moslehi (Los Altos, California); Joshua Kuehn (Boulder Creek, California); Richard J. Black (Menlo Park, California) |
| ABSTRACT | A temperature correcting pressure gauge which has a diaphragm having at least one surface coupled to a source of pressure to be measured, the diaphragm first surface having a first FBG from a first optical fiber attached in an appropriately sensitive region of the diaphragm, a FBG from a second optical fiber attached to the opposite surface from the first FBG, the first and second FBGs reflecting or transmitting optical energy of decreasing or increasing wavelength, respectively, in response to an applied pressure. The first and second FBGs have nominal operating wavelength ranges that are adjacent to each other but are exclusive ranges and the FBGs also have closely matched pressure coefficients and temperature coefficients. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/523933 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/246 (20130101) G01L 11/025 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 6/0218 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 11844347 | Cope et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Accelerated Ag Technologies, LLC (Ankeny, Iowa) |
| ASSIGNEE(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| INVENTOR(S) | Jason Cope (Ankeny, Iowa); George Singletary (Ankeny, Iowa); Todd Krone (Des Moines, Iowa); Sara Katherine Etter (Bondurant, Iowa) |
| ABSTRACT | Described are methods of grain production with field conditioned pollen. A method of the present invention includes growing one or more designated female plants that include both female and male components, collecting fresh pollen from designated male plants from a different genetic background, and subjecting the fresh pollen to field conditions, which may regulate pollen moisture content. The field conditioning conditions may include a relative humidity ranging from about 50% to about 100%, a temperature ranging from about −10-10° C., and an air pressure ranging from about 15 kPa to about 150 kPa. These conditions may result in pollen having a moisture content of about 40% to about 58%. The one or more designated female plants are intentionally cross-pollinated with the field conditioned pollen and then grown to maturity such that the grain may be harvested therefrom. Also provided is a method of preventing undesirable pollination in grain production. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458944 |
| ART UNIT | 1662 — Plants |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844348 | Cope et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| ASSIGNEE(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| INVENTOR(S) | Jason Cope (Ankeny, Iowa); George Singletary (Ankeny, Iowa); Todd Krone (Des Moines, Iowa); Sara Katherine Etter (Bondurant, Iowa) |
| ABSTRACT | Described are methods of preserving cereal crop pollen and/or anthers. A method of the present invention includes collecting fresh pollen and/or anthers and introducing the pollen and/or anthers to field conditioning conditions which regulate pollen moisture content. The field conditioning conditions may include a an air flow at a humidity ranging from 0% to about 99% and a temperature ranging from about −10-10° C. The field conditioning conditions may further include a flow of one or more continuously refreshed, selected gases. The field conditioning conditions may dehydrate the pollen to achieve a pollen moisture content of about 15% to about 35%. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/686939 |
| ART UNIT | 1662 — Plants |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844815 | Aroian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| INVENTOR(S) | Raffi Van Aroian (Worcester, Massachusetts); Gary R. Ostroff (Worcester, Massachusetts) |
| ABSTRACT | Compositions and methods for treating or reducing the severity of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a composition comprising isolated native, bioactive nematicidal crystals formed from a single type of nematicidal crystal protein. The isolated native, bioactive nematicidal crystals are substantially free of any bacterial spores or host bacterial proteins, other than nematicidal crystal protein in the form of a crystal. Methods for making isolated native, bioactive nematicidal crystals are also described. The crystal proteins may be full length, truncated, variant, or sub-variant Cry proteins. Examples of crystal proteins include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. |
| FILED | Tuesday, May 22, 2018 |
| APPL NO | 16/607677 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/48 (20130101) A61K 35/741 (20130101) Original (OR) Class A61K 38/164 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 11844724 | Grubbs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California); The Regents of the University of California (Oakland, California); United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); The Regents of the University of California (Oakland, California); United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Robert H. Grubbs (South Pasadena, California); Marshall L Stoller (San Francisco, California); Ying Han (Burlingame, California); Frank L. Brodie (Durham, North Carolina) |
| ABSTRACT | A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509641 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00745 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844779 | Patel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS OFFICE OF GENERAL (Washington, District of Columbia) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | Niketa A. Patel (Land O' Lakes, Florida); Rekha S. Patel (Tampa, Florida); Robert Pleasants Sparks (Tampa, Florida); Wayne Charles Guida (Saint Pete Beach, Florida) |
| ABSTRACT | Provided herein are formulations that can contain an effective amount of a PKCδ inhibitor. Also provided herein are methods of inhibiting a PKCδ in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKCδ. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/472793 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/36 (20130101) A61K 31/357 (20130101) A61K 31/444 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/4035 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4965 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11844802 | Boden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia); The US Govt as represented by the Dept of VA (Washington, District of Columbia) |
| INVENTOR(S) | Scott D. Boden (Atlanta, Georgia); Sreedhara Sangadala (Atlanta, Georgia) |
| ABSTRACT | The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936184 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) Original (OR) Class A61K 31/53 (20130101) A61K 38/1875 (20130101) A61K 2300/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 2300/412 (20130101) A61L 2430/02 (20130101) Heterocyclic Compounds C07D 251/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 11846077 | Sicking et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sicking Safety Systems LLC (Indian Springs Village, Alabama) |
| ASSIGNEE(S) | Sicking Safety Systems LLC (Indian Springs Village, Alabama) |
| INVENTOR(S) | Dean L. Sicking (Indian Springs Village, Alabama); Dakotah Sicking (Keller, Texas); Steven D. Thompson (Bessemer, Alabama); Kenneth Walls (Trussville, Alabama); Kevin D. Schrum (Pelham, Alabama); Joseph Schwertz (Birmingham, Alabama); David Littlefield (Vestavia Hills, Alabama); Andrew Dameron (Birmingham, Alabama) |
| ABSTRACT | Guardrail, guardrail terminal, and support post designs that improve control of a vehicle during collisions are described. The disclosed designs also reduce the likelihood of intrusion into vehicle systems and the occupant compartment(s). Embodiments include folding and/or flattening of the guardrail and controlling the folded and flattened guardrail to avoid intrusion into the vehicle. Other embodiments include containing the guardrail in an impact head of a guardrail terminal, which also avoids vehicle intrusion. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 18/045060 |
| ART UNIT | 3678 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Additional Work, Such as Equipping Roads or the Construction of Platforms, Helicopter Landing Stages, Signs, Snow Fences, or the Like E01F 15/143 (20130101) Original (OR) Class E01F 15/0423 (20130101) E01F 15/0461 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11847923 | Maloney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Administrator of the Federal Aviation Administration (Atlantic City International Airport, New Jersey) |
| ASSIGNEE(S) | The United States of America, as represented by the Administrator of the Federal Aviation Administration (Washington, District of Columbia) |
| INVENTOR(S) | Philip Maloney (Mays Landing, New Jersey); Andrew A. Tasso (Vineland, New Jersey) |
| ABSTRACT | Robust techniques for the collection, storage, and processing of data from disparate UAS data sources in an unmanned aircraft systems (UAS) operations environment. A data-agnostic platform hosts a plurality of clients and client services. Baseline configurations and customizations are input to configure the platform for collection, retention, and/or processing of the data, and the client services are automatically configured based in part on those baseline configurations and customizations. Client services are logically arranged within each device memory as a plurality of operational groupings with a predetermined sequence order and a predetermined priority and executed according to the predetermined sequence order and predetermined priority. Data from the data sources is translated into customized data based at least, in part, on the configuration information, and validated for storage. Validated data may be analyzed according to prescribed functions and formulas and/or reported out according to a preferred format, based on the configuration information. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 17/464879 |
| ART UNIT | 2154 — Data Bases & File Management |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/018 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/008 (20130101) G07C 5/0808 (20130101) Traffic Control Systems G08G 5/0013 (20130101) G08G 5/0043 (20130101) Original (OR) Class G08G 5/0069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 11845216 | Gandhiraman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITIES SPACE RESEARCH ASSOCIATION (Columbia, Maryland) |
| ASSIGNEE(S) | UNIVERSITIES SPACE RESEARCH ASSOCIATION (Columbia, Maryland) |
| INVENTOR(S) | Ramprasad Gandhiraman (Sunnyvale, California); Meyya Meyyappan (Pacifica, California); Jessica E. Koehne (Portola Valley, California) |
| ABSTRACT | A device and method for printing 3D articles including electronic and functional elements including 3D printer and a plasma jet printer based on a dielectric barrier atmospheric pressure plasma jet system in which both printing and in-situ treatment and post-deposition treatment can be carried out to tailor the materials characteristics. Plasma jet printer comprising of electrodes in the nozzle/print head for applying electric field and generating atmospheric plasma that could be used for non-gravity based highly directional printing in any direction. Integration of dielectric barrier plasma printer and plasma treatment jets with the 3D printer increases the capability of embedding high performance electronics in a 3D printed structure aiding in additive manufacturing of functional devices. Ability to use a range of materials for print head assembly including micro machined silicon increases the resolution of the plasma jet printer to sub-micron level. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/666695 |
| ART UNIT | 1745 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/16 (20130101) B22F 3/16 (20130101) B22F 10/25 (20210101) B22F 10/25 (20210101) B22F 10/25 (20210101) B22F 10/50 (20210101) B22F 10/50 (20210101) B22F 10/60 (20210101) B22F 10/60 (20210101) B22F 12/22 (20210101) B22F 12/53 (20210101) B22F 12/53 (20210101) B22F 12/53 (20210101) B22F 12/55 (20210101) B22F 12/55 (20210101) B22F 12/55 (20210101) B22F 12/70 (20210101) B22F 12/82 (20210101) B22F 2202/13 (20130101) B22F 2202/13 (20130101) B22F 2202/13 (20130101) B22F 2999/00 (20130101) B22F 2999/00 (20130101) B22F 2999/00 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Original (OR) Class B29C 64/188 (20170801) B29C 64/205 (20170801) B29C 64/209 (20170801) B29C 64/321 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11845834 | Ghose et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Arlington, Virginia); United States Government, as Represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Sayata Ghose (Sammamish, Washington); Marcus Anthony Belcher (Sammamish, Washington); John W. Connell (Yorktown, Virginia) |
| ABSTRACT | Compositions including a polyamide, and compaction rollers for an automated fiber placement machine incorporating the composition are provided. The polyamide may be a reaction product of at least one diamine and an aromatic dicarboxylic acid, a hydroxy benzoic acid, or their respective ester or acyl halide derivatives. The at least one diamine may include an amino terminated perfluorinated alkyl ether polymer or oligomer. The composition may have a thermal conductivity of from about 0.2 to about 50 Watts per meter Kelvin (Wm−1K−1). |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/444117 |
| ART UNIT | 1767 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/382 (20130101) Presses in General B30B 3/005 (20130101) B30B 9/28 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/32 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/013 (20180101) C08K 5/09 (20130101) C08K 2201/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 11848349 | Keefe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HRL LABORATORIES, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL LABORATORIES, LLC (Malibu, California) |
| INVENTOR(S) | Andrew C. Keefe (Encino, California); Geoffrey P. McKnight (Los Angeles, California); Alexander R. Gurga (Canoga Park, California); Ryan Freeman (Los Angeles, California) |
| ABSTRACT | A method of forming a curved semiconductor includes: forming a device layer on a semiconductor substrate; forming a metal layer on the device layer; removing the semiconductor substrate from the device layer; and curving the device layer and the metal layer. |
| FILED | Friday, April 19, 2019 |
| APPL NO | 16/389238 |
| ART UNIT | 2898 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14607 (20130101) H01L 27/14683 (20130101) Original (OR) Class H01L 27/14806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848676 | Whiteley |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | Synopsys, Inc. (Sunnyvale, California) |
| INVENTOR(S) | Stephen Whiteley (Sunnyvale, California) |
| ABSTRACT | The present disclosure relates to improved electronic structures for propagating logic states between superconducting digital logic gates using a three-junction interferometer in a receiver circuit to reduce reflecting signals that otherwise result in distortions in the signals being transmitted between the gates. Other improved electronic structures comprise passive transmission lines (PTLs) with transmission line matching circuitry that has previously been avoided. The matching circuitry minimizes generation and propagation of spurious pulses emitted by Josephson junctions used in the digital logic gates. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181869 |
| ART UNIT | 2845 — Electrical Circuits and Systems |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/035 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pulse Technique H03K 3/38 (20130101) Original (OR) Class H03K 17/92 (20130101) H03K 19/195 (20130101) H03K 19/1954 (20130101) Electric solid-state devices not otherwise provided for H10N 60/12 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 11844337 | Hopkins |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America, as represented by the Secretary of Commerce (Silver Spring, Maryland) |
| ASSIGNEE(S) | UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Silver Spring, Maryland) |
| INVENTOR(S) | Nicholas Hopkins (Gautier, Mississippi) |
| ABSTRACT | Embodiments of the present invention relate to methods and apparatus for sorting undesired marine species during trawling, provides a pliable grid when the trawl net is pulled from the water and wound tightly on the net reel, and when the trawl is deployed in the water, the apparatus is fixed into place inside the trawl and holding its shape with consistent grid spacing. Marine species sorting apparatus in accordance with embodiments of the present invention includes grid, back straps, and lead ring. Grid includes a plurality of bars surrounded by grid frame. Grid frame is attached to lead ring at an angle using terminal couplers. Lead ring supports grid and secures marine species sorting apparatus in trawl webbing referred to as the extension. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/192321 |
| ART UNIT | 3643 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 73/04 (20130101) Original (OR) Class A01K 75/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
General Services Administration (GSA)
| US 11848174 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Kieran Wilson (Oviedo, Florida); Miles Bengtson (Broomfield, Colorado); Hanspeter Schaub (Golden, Colorado); Dalton Turpen (Boulder, Colorado) |
| ABSTRACT | Various embodiments of the present technology generally relate to devices and methods for generating and directing energetic electrons toward a target. More specifically, some embodiments relate to devices, systems, and methods for generating and directing energetic electrons based in the photoelectric effect and directing electric field-focused beams of the energetic electrons toward a target. Electron guns according to the present technology include one or more light sources to stimulate electron transmission, and a series of differentially charged stages to provide a hollow path allowing electrons generated by the photoelectric effect of the light irradiated on interior surfaces defining the path through the stages to travel to an exit of the electron gun. Each of the differentially charged stages have a different potential, thereby providing electrons having two or more different and tunable energy levels exiting as a beam from the electron gun. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186835 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/065 (20130101) H01J 37/305 (20130101) Original (OR) Class H01J 2237/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 11849065 | Balasubramaniyan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Vijay Balasubramaniyan (Atlanta, Georgia); Mustaque Ahamad (Atlanta, Georgia); Patrick Gerard Traynor (Decatur, Georgia); Michael Thomas Hunter (Atlanta, Georgia); Aamir Poonawalla (Atlanta, Georgia) |
| ABSTRACT | Various embodiments of the invention are detection systems and methods for detecting call provenance based on call audio. An exemplary embodiment of the detection system can comprise a characterization unit, a labeling unit, and an identification unit. The characterization unit can extract various characteristics of networks through which a call traversed, based on call audio. The labeling unit can be trained on prior call data and can identify one or more codecs used to encode the call, based on the call audio. The identification unit can utilize the characteristics of traversed networks and the identified codecs, and based on this information, the identification unit can provide a provenance fingerprint for the call. Based on the call provenance fingerprint, the detection system can identify, verify, or provide forensic information about a call audio source. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/338523 |
| ART UNIT | 2643 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/0829 (20130101) H04L 65/1076 (20130101) Telephonic Communication H04M 1/68 (20130101) H04M 3/2281 (20130101) Original (OR) Class H04M 7/0078 (20130101) H04M 2203/558 (20130101) H04M 2203/6027 (20130101) H04M 2203/6045 (20130101) Wireless Communication Networks H04W 12/02 (20130101) H04W 12/12 (20130101) H04W 12/63 (20210101) H04W 12/65 (20210101) H04W 24/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 11846077 | Sicking et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sicking Safety Systems LLC (Indian Springs Village, Alabama) |
| ASSIGNEE(S) | Sicking Safety Systems LLC (Indian Springs Village, Alabama) |
| INVENTOR(S) | Dean L. Sicking (Indian Springs Village, Alabama); Dakotah Sicking (Keller, Texas); Steven D. Thompson (Bessemer, Alabama); Kenneth Walls (Trussville, Alabama); Kevin D. Schrum (Pelham, Alabama); Joseph Schwertz (Birmingham, Alabama); David Littlefield (Vestavia Hills, Alabama); Andrew Dameron (Birmingham, Alabama) |
| ABSTRACT | Guardrail, guardrail terminal, and support post designs that improve control of a vehicle during collisions are described. The disclosed designs also reduce the likelihood of intrusion into vehicle systems and the occupant compartment(s). Embodiments include folding and/or flattening of the guardrail and controlling the folded and flattened guardrail to avoid intrusion into the vehicle. Other embodiments include containing the guardrail in an impact head of a guardrail terminal, which also avoids vehicle intrusion. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 18/045060 |
| ART UNIT | 3678 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Additional Work, Such as Equipping Roads or the Construction of Platforms, Helicopter Landing Stages, Signs, Snow Fences, or the Like E01F 15/143 (20130101) Original (OR) Class E01F 15/0423 (20130101) E01F 15/0461 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Nuclear Regulatory Commission (NRC)
| US 11844835 | Garner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); Nanovis, LLC (Columbia City, Indiana) |
| ASSIGNEE(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana); NANOVIS, LLC (Columbia City, Indiana) |
| INVENTOR(S) | Allen Lawrence Garner (West Lafayette, Indiana); Ram Anand Vadlamani (West Lafayette, Indiana); David Alan Detwiler (Columbia City, Indiana) |
| ABSTRACT | Provided is a method of reducing a number of viable microbes, including contacting microbes with an antibiotic compound and applying pulses of electricity having a duration of between about 50 nanoseconds and about 900 nanoseconds. The pulses of electricity may have an intensity between about 20 kV/cm and about 40 kV/cm. The pulses of electricity may be applied at a frequency of between about 0.1 Hz and about 10 Hz. The microbes may be a gram-negative or a gram-positive strain of bacteria and the antibiotic may be applied at a concentration for a duration, wherein applying the antibiotic to the strain at the concentration for the duration does not reduce a viable number of bacteria of the strain as much, or at all, when the pulses of electricity are not also applied. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461143 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/341 (20130101) A61K 31/496 (20130101) A61K 31/575 (20130101) A61K 31/702 (20130101) A61K 31/5377 (20130101) A61K 31/7048 (20130101) A61K 38/14 (20130101) A61K 41/0023 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 11845789 | Chan-Hui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THERACLONE SCIENCES, INC. (Seattle, Washington); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); INTERNATIONAL AIDS VACCINE INITIATIVE, INC. (New York, New York) |
| ASSIGNEE(S) | THERACLONE SCIENCES, INC. (Seattle, Washington); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); INTERNATIONAL AIDS VACCINE INITIATIVE, INC. (New York, New York) |
| INVENTOR(S) | Po-Ying Chan-Hui (Bellevue, Washington); Katherine Doores (San Diego, California); Michael Huber (Zurich, Switzerland); Stephen Kaminsky (Bronx, New York); Steven Frey (Redmond, Washington); Ole Olsen (Everett, Washington); Jennifer Mitcham (Redmond, Washington); Matthew Moyle (Redmond, Washington); Sanjay K. Phogat (Frederick, Maryland); Dennis R. Burton (La Jolla, California); Laura Majorie Walker (San Diego, California); Pascal Raymond Georges Poignard (San Diego, California); Wayne Koff (Stony Brook, New York); Melissa Danielle De Jean De St. Marcel Simek-Lemos (Brooklyn, New York) |
| ABSTRACT | The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/376276 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/51 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16111 (20130101) C12N 2740/16122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 11845961 | Tuan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Rocky S. Tuan (Pittsburgh, Pennsylvania); Hang Lin (Pittsburgh, Pennsylvania); Thomas P. Lozito (Pittsburgh, Pennsylvania); Peter Alexander (Wexford, Pennsylvania); Douglas Allen Nelson, Jr. (Pittsburgh, Pennsylvania); Riccardo Gottardi (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/151921 |
| ART UNIT | 1796 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/34 (20130101) C12M 35/04 (20130101) C12M 35/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) Original (OR) Class C12N 2502/1311 (20130101) C12N 2502/1317 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 11847132 | Tommasi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Pierpaolo Tommasi (Dublin, Ireland); Alessandra Pascale (Castleknock, Ireland); Stephane Deparis (Dublin, Ireland) |
| ABSTRACT | Embodiments facilitating data exploration in a computing environment by a processor. A multidimensional dataset may be received. The multidimensional dataset may be processed according to booting operation parameters. A visualization and exploration of an interactive representation of one or more probabilistic models using multidimensional dataset. |
| FILED | Tuesday, September 03, 2019 |
| APPL NO | 16/559320 |
| ART UNIT | 2162 — Data Bases & File Management |
| CURRENT CPC | Electric Digital Data Processing G06F 16/26 (20190101) Original (OR) Class G06F 16/283 (20190101) Computer Systems Based on Specific Computational Models G06N 7/01 (20230101) G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11848391 | Delaunay |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HRL LABORATORIES, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL LABORATORIES, LLC (Malibu, California) |
| INVENTOR(S) | Pierre-Yves Delaunay (Santa Monica, California) |
| ABSTRACT | An infrared detector and a method for manufacturing it are disclosed. The infrared detector contains an absorber layer responsive to infrared light, a barrier layer disposed on the absorber layer, a plurality of contact structures disposed on the barrier layer; and an oxide layer disposed above the barrier layer and between the plurality of the contact structures, wherein the oxide layer reduces the dark current in the infrared detector. The method disclosed teaches how to manufacture the infrared detector. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236303 |
| ART UNIT | 2893 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/0216 (20130101) Original (OR) Class H01L 31/0224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, December 19, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20231219.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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