FedInvent™ Patent Applications
Application Details for Thursday, January 04, 2024
This page was updated on Friday, January 05, 2024 at 05:30 AM GMT
Department of Health and Human Services (HHS)
| US 20240000316 | BRUZA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Petr BRUZA (Lebanon, New Hampshire); Brian POGUE (Hanover, New Hampshire) |
| ABSTRACT | A system and method for depth-resolved imaging of fluorophore concentrations in tissue uses a pulsed light source stimulus wavelength to illuminate the tissue; and a time-gated electronic camera such as a single-photon avalanche detector camera to observe the tissue in multiple time windows after start of each light pulse. A filter device is between the tissue and the electronic camera with fluorescent imaging and stimulus wavelength settings. an image processor receives reflectance images and fluorescent emissions images from the time-gated camera and processes these images into depth and quantity resolved images of fluorophore concentrations in the tissue. Then image processor derives a fluorescence lifetime signal from the received temporal fluorescence signals and derives from these fluorescence lifetime signals biochemical property images of the tissue. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/229086 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Original (OR) Class A61B 5/7425 (20130101) A61B 2560/0233 (20130101) A61B 2576/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/645 (20130101) G01N 2021/6471 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000322 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shuai Xu (Bala Cynwyd, Pennsylvania); Hyoyoung Jeong (Evanston, Illinois); Jong Yoon Lee (Evanston, Illinois); Kun Hyuck Lee (Evanston, Illinois); John A. Rogers (Wilmette, Illinois) |
| ABSTRACT | This invention discloses an electronic device for measuring physiological parameters of a living subject including at least a first inertial measurement unit (IMU) and a second IMU, the first IMU and the second IMU are time-synchronized to and spatially and mechanically separated from each other; and a microcontroller unit (MCU) electronically coupled to the first IMU and the second IMU for processing of data streams from the first IMU and the second IMU. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 18/034893 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1135 (20130101) A61B 5/02055 (20130101) Original (OR) Class A61B 5/4205 (20130101) A61B 5/4803 (20130101) A61B 5/6832 (20130101) A61B 5/7214 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000384 | Linnes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Jacqueline Callihan Linnes (West Lafayette, Indiana); Orlando Sanguinette Hoilett (West Lafayette, Indiana); Ashlyn Twibell (South Bend, Indiana); Hyowon Lee (West Lafayette, Indiana); Rohit Srivastava (West Lafayette, Indiana); Jason D. Ummel (West Lafayette, Indiana); Ryan Lindsey (Evansville, Indiana) |
| ABSTRACT | A device for measuring and monitoring heart rate, respiration rate, and oxygen saturation of a subject is disclosed, which includes a biometric sensor board having a photosensor adapted to measure reflectance of red and infrared lights off skin tissue, wherein the biometric sensor board adapted to control one or more light emitting diodes (LEDs), wherein brightness of the LEDs are automatically adjusted to account for skin tone, thereby generating photoplethysmographic data, a processor unit adapted to analyze data measured by the biometric sensor board, and a display adapted to display results of the processed data remotely. |
| FILED | Sunday, July 23, 2023 |
| APPL NO | 18/225144 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/0205 (20130101) A61B 5/681 (20130101) Original (OR) Class A61B 5/743 (20130101) A61B 5/0816 (20130101) A61B 5/1112 (20130101) A61B 5/02433 (20130101) A61B 5/4833 (20130101) A61B 5/7207 (20130101) A61B 5/7257 (20130101) A61B 5/14552 (20130101) A61B 2503/12 (20130101) A61B 2560/0214 (20130101) A61B 2560/0228 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000391 | Entenberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Entenberg (Granite Springs, New York); John S. Condeelis (Bronx, New York); Sonia E. Voiculescu (Bronx, New York) |
| ABSTRACT | Methods and apparatus are provided for high resolution intravital imaging and for chronic optical imaging of tissues such as lung. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/339020 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/0068 (20130101) A61B 5/0071 (20130101) A61B 5/418 (20130101) A61B 5/704 (20130101) Original (OR) Class A61B 5/4222 (20130101) A61B 5/4872 (20130101) A61B 2503/42 (20130101) Optical Elements, Systems, or Apparatus G02B 21/367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000726 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); The United States as Represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith T. Wilson (Nashville, Tennessee); John A. Oates (Nashville, Tennessee); Olivier Boutaud (Nashville, Tennessee); Venkataraman Amarnath (Nashville, Tennessee); Erica J. Carrier (Nashville, Tennessee); Alain P. Gobert (Nashville, Tennessee) |
| ABSTRACT | Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein. |
| FILED | Monday, July 10, 2023 |
| APPL NO | 18/220137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/135 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000735 | Weimbs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Augusta University Research Institute, Inc. (Augusta, Georgia) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Augusta University Research Institute, Inc. (Augusta, Georgia) |
| INVENTOR(S) | Thomas Weimbs (Santa Barbara, California); Jacob Torres (Santa Barbara, California); Muthusamy Thangaraju (Evans, Georgia) |
| ABSTRACT | Compositions and methods for supporting health, especially renal health, comprising ketonic agents that recapitulate beneficial effects of ketosis by exogenously administered agents. The agents include beta-hydroxybutyrate (BHB), analogs thereof, and GPR109A agonists. The agents may further include crystal precipitation inhibitors which synergistically improve treatment of certain renal conditions, such as citrate. The agents may be used in dietary supplements and therapeutic compositions for the treatment of cystic kidney diseases such as polycystic kidney disease, ciliopathies, and other conditions. Certain formulations enable convenient administration of the beneficial combination product in powdered form for mixing with liquid. Such formulations can be salt-balanced, and may be free of sodium and/or silicates, and are well tolerated. The formulations may be provided in a container and measuring implement to enable convenient measurement of dosages. |
| FILED | Friday, August 04, 2023 |
| APPL NO | 18/365856 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/20 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 31/047 (20130101) A61K 31/194 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000741 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenbin Lin (Chicago, Illinois); Ralph R. Weichselbaum (Chicago, Illinois); Hua Liang (Chicago, Illinois); Yingying Li (Chicago, Illinois) |
| ABSTRACT | Methods of treating cancer comprising the use of combinations of a retinoid, e.g., all-trans retinoic acid (ATRA), and radiotherapy are described. The administration of a retinoid can enhance the effect of radiotherapy, including enhancing fractionated, low-dose radiotherapy. Use of the combination increases tumor necrosis factor alpha (TNF-α)- and inducible nitric oxide synthase (iNOS)-producing inflammatory macrophages in local (radiated) and distal (non-radiated) tumors. The methods can optionally further involve the use of checkpoint blockade immunotherapy. |
| FILED | Monday, June 05, 2023 |
| APPL NO | 18/329289 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/203 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000753 | Shirasu-Hiza et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mimi Shirasu-Hiza (New York, New York); Julie Canman (New York, New York); Matt Ulgherait (New York, New York) |
| ABSTRACT | The present disclosure relates to methods and compositions for increasing or extending lifespan and/or healthspan and/or delaying aging using agents which mimic the effects of time-restricted feeding and/or activate or enhance circadian-regulated autophagy. In particular, the present disclosure relates to increasing certain proteins including UNC-51-like kinase (ULK1), adenosine monophosphate protein kinase (AMPK) and microtubule-associated protein, light chain 3 (LC3), and decreasing other certain proteins including ribosomal protein S6 kinase beta-1 (S6K) protein in order to increase lifespan and/or healthspan and delay aging. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 18/016516 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/155 (20130101) A61K 31/436 (20130101) A61K 31/496 (20130101) A61K 31/4188 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000758 | BLAU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Helen M. BLAU (Stanford, California); Adelaida Rosa PALLA (Stanford, California); Meenakshi RAVICHANDRAN (Stanford, California) |
| ABSTRACT | The present disclosure provides methods of increasing mitochondrial biogenesis, function, or both in a tissue of a subject by administering to the subject an amount of a 15-PGDH inhibitor effective to inhibit 15-PGDH activity and/or reduce 15-PGDH levels in the subject. The methods described herein are useful for treating diseases, disorders, or conditions associated with dysfunctional mitochondria and/or increased oxidative stress including mitochondrial diseases. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 18/249948 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4365 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000774 | Philips et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University in St. Louis (St. Louis, Missouri); New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Philips (St. Louis, Missouri); Kathryn Moore (New York, New York); Pallavi Chandra (St. Louis, Missouri); Mireille Ouimet (New York, New York) |
| ABSTRACT | Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/338717 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/336 (20130101) A61K 31/352 (20130101) A61K 31/365 (20130101) A61K 31/495 (20130101) Original (OR) Class A61K 31/4453 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000787 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Qiwei Yang (Bolingbroke, Illinois); Ayman Al-Hendy (Hinsdale, Illinois) |
| ABSTRACT | In aspects, the present disclosure provides a method of treating or preventing a uterine leiomyosarcoma in a female mammal, the method comprising, consisting essentially of, or consisting of administering to the female mammal an effective amount of an inhibitor of bromodomain-containing protein 9 (BRD9). |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345461 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000806 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beibei Chen (Pittsburgh, Pennsylvania); Toren Finkel (Pittsburgh, Pennsylvania); Yuan Liu (Pittsburgh, Pennsylvania) |
| ABSTRACT | This document provides compounds that can inhibit CB1 activity within a mammal (e.g., a human), as well as the methods of using such compounds for treating diseases, disorders, and conditions such as obesity, fear, metabolic-related disorders, diabetes, dyslipidaemia, and atherosclerosis. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 18/022654 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/635 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000814 | Bogenschutz |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Bogenschutz (New York, New York) |
| ABSTRACT | This invention provides methods for treating a human subject afflicted with alcohol use disorder (AUD) comprising administering to the subject a therapeutically effective amount of a psilocybin-based compound. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/153140 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) Original (OR) Class A61K 31/5513 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/32 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000824 | ROSSI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California); AUM LIFE TECH, INC. (Philadelphia, Pennsylvania); THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (Montreal, Canada) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California); AUM LIFE TECH, INC. (Philadelphia, Pennsylvania); THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (Montreal, Canada) |
| INVENTOR(S) | John J. ROSSI (Azusa, California); Masad J. DAMHA (Montreal, Canada); Veenu AISHWARYA (Philadephia, Pennsylvania); Mayumi TAKAHASHI (Pasadena, California); Haitang LI (Duarte, California) |
| ABSTRACT | The disclosure relates to synthetic oligonucleotides that bind at least a portion of a dimerization initiation site (DIS) of a retrovirus genomic ribonucleic acid (RNA) molecule. In some aspects, the synthetic oligonucleotides include a 2′-deoxy-2′-fluoroarabinonucleotide (2′-FANA)-modified nucleotide sequence. In some embodiments, the 2′-FANA-modified nucleotide sequence inhibits dimerization of retroviral genomes (e.g., an HIV genome). Other embodiments include methods of inhibiting expression of a retrovirus using the synthetic oligonucleotide, and methods of treating or preventing a retroviral infection. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/344507 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7115 (20130101) Original (OR) Class A61K 31/7125 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1132 (20130101) C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/323 (20130101) C12N 2310/341 (20130101) C12N 2310/346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000843 | Fehniger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd Fehniger (St. Louis, Missouri); Melissa Berrien-Elliott (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure are provisions for methods of, and compositions for, increasing NK cell anti-tumor response, screening donors, and predicting response to NK cell therapy. |
| FILED | Thursday, May 25, 2023 |
| APPL NO | 18/323898 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/19 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) C07K 16/2815 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000851 | KAUSHAL |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunjay KAUSHAL (Chicago, Illinois) |
| ABSTRACT | Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/459692 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Original (OR) Class A61K 38/19 (20130101) A61K 38/195 (20130101) A61K 38/1833 (20130101) A61K 38/1866 (20130101) A61K 38/1891 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000860 | David et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Maude M. David (Corvallis, Oregon); Christine Tataru (Corvallis, Oregon); Alexandra Rose Phillips (Corvallis, Oregon); Shoko Kawana (Brisbane, California); Xiaochen Yin (Brisbane, California); Marie Peras (Brisbane, California); Todd Z. DeSantis (Brisbane, California); Brianna Chrisman (Stanford, California); Dennis Wall (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maude M. David (Corvallis, Oregon); Christine Tataru (Corvallis, Oregon); Alexandra Rose Phillips (Corvallis, Oregon); Shoko Kawana (Brisbane, California); Xiaochen Yin (Brisbane, California); Marie Peras (Brisbane, California); Todd Z. DeSantis (Brisbane, California); Brianna Chrisman (Stanford, California); Dennis Wall (Stanford, California) |
| ABSTRACT | Methods and compositions are provided herein for treating autism spectrum disorder in a subject, using one or more metabolites such as glutamate, malate, ursodeoxycholate, 5-dodecenoate, N-acetyl-L-glutamate, citrate, glycodeoxycholate, and carboxyethyl aminobutyric acid (CEGABA) and/or using one or more bacterial species such as bacterial species from the Streptococcaceae, Lachnospiraceae, Ruminococcaceae, Bacteroidaceae, Butyricicoccaceae, and/or Pasteurellaceae families; from the Streptococcus, Blautia, Haemophilus, Faecalibacterium, Bacteroides, Roseburia, Fusicatenibacter, Lachnospira, and/or Agathobaculum genera, or Blautia wexlerae, Bacteroides vulgatus, Bacteroides ovatus, Roseburia inulinivorans, Roseburia intestinalis, Fusicatenibacter saccharivorans, and/or Agathobaculum butyriciproducens. |
| FILED | Tuesday, April 18, 2023 |
| APPL NO | 18/302656 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/231 (20130101) A61K 35/74 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000862 | Mazmanian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarkis K. Mazmanian (Porter Ranch, California); Timothy R. Sampson (Los Angeles, California) |
| ABSTRACT | Disclosed herein are methods and compositions that can be used to improve motor deficits and neuroinflammation in subjects in need, for example subjects suffering from neurodegenerative disorders (e.g., Parkinson's disease). Also disclosed are methods and compositions that can be used to diagnose neurodegenerative disorders, such as Parkinson's disease. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335889 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) Original (OR) Class A61K 38/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000863 | Zargar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Amin Zargar (Berkeley, California); Jay D. Keasling (Berkeley, California) |
| ABSTRACT | A topical, skin probiotic formulation comprises a living population of Corynebacterium glutamicum bacteria genetically-engineered to produce a skin-bioactive agent, and a nutrient source for the bacteria. |
| FILED | Tuesday, August 29, 2023 |
| APPL NO | 18/458139 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 35/741 (20130101) Original (OR) Class A61K 38/55 (20130101) A61K 38/164 (20130101) A61K 38/2066 (20130101) A61K 47/26 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000873 | Peng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Kah-Whye Peng (Rochester, Minnesota); Stephen James Russell (Rochester, Minnesota); Camilo Ayala Breton (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials related to vesicular stomatitis viruses. For example, replication-competent vesicular stomatitis viruses, nucleic acid molecules encoding replication-competent vesicular stomatitis viruses, methods for making replication-competent vesicular stomatitis viruses, and methods for using replication-competent vesicular stomatitis viruses to treat cancer or infectious diseases are provided. |
| FILED | Tuesday, June 20, 2023 |
| APPL NO | 18/211692 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/766 (20130101) Original (OR) Class A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2760/18422 (20130101) C12N 2760/20222 (20130101) C12N 2810/859 (20130101) C12N 2810/6081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000883 | SUGAHARA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kazuki SUGAHARA (Fort Lee, New Jersey); Andrew M. LOWY (San Diego, California) |
| ABSTRACT | The invention described relates to the newly discovered ability of tumor internalizing arginylglycylaspartic acid (iRGD) peptides to alter the immune cell landscape in pancreatic ductal adenocarcinoma (PDAC) and other cancers. The iRGD peptides sensitize the cancer to immune checkpoint inhibitors, for example anti-PD-L1, anti-PD-L1, anti-PD-1, and anti-CTLA4 monoclonal antibodies to specifically deplete Tregs within the tumor, resulting in expansion of intratumoral CD8+ T cells (effector cells). This provides methods of treating cancers such as PDAC, preferably in synergistic combination with chemotherapy and immunotherapy, which leads to reduced tumor burden and prolonged survival. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 18/252069 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000885 | TANGY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); UNIVERSITEIT UTRECHT HOLDING B.V. (utrecht, Netherlands) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frédéric TANGY (Les Lilsa, France); Pierre-Olivier VIDALAIN (Lyon, France); James R. GOLDENRING (Nashville, Tennessee); Joseph T. Roland (Nashville, Tennessee); Lynne A. LAPIERRE (Nashville, Tennessee); Elizabeth MANNING (Nashville, Tennessee); Cornelis Alexander Maria DE HAAN (Utrecht, Netherlands) |
| ABSTRACT | Disclosed herein is a method for treating or preventing a coronavirus infection in a subject that involves administering to the subject an effective amount of a composition comprising an agent that disrupts the binding of coronavirus membrane glycoprotein (M protein) and Myosin Vb protein (MYO5B). Also disclosed herein is a method for identifying an agent for treating or preventing a coronavirus infection that involves providing a system comprising coronavirus membrane glycoprotein (M protein) and human Myosin Vb protein (MYO5B) with conditions suitable for binding of the M protein and MYO5B; contacting the system with a candidate agent; and assaying the system for binding of M protein and MYO5B. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 18/251497 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 38/162 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000894 | MCLAUGHLIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tracey L. MCLAUGHLIN (Stanford, California); Colleen M. CRAIG (Stanford, California) |
| ABSTRACT | Compositions and methods for treating hyperinsulinemic hypoglycemia, such as hyperinsulinemic hypoglycemia after bariatric surgery, are provided. In some embodiments, an effective amount of the glucagon-like peptide-1 receptor antagonist exendin(9-39) is subcutaneously administered twice per day. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172546 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/10 (20130101) A61K 9/0019 (20130101) A61K 38/17 (20130101) A61K 38/22 (20130101) A61K 38/26 (20130101) A61K 38/2278 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000926 | BEHRENS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vaxcyte, Inc. (San Carlos, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher R. BEHRENS (San Francisco, California); Paresh AGARWAL (Millbrae, California); Lu YIN (Santa Cruz, California); Peter T. DAVEY (Foster City, California); Angie A. SEDRA (Foster City, California) |
| ABSTRACT | The present disclosure provides a process for purifying high-molecular weight bacterial polysaccharides (e.g., cell wall polysaccharides), and polypeptide-polysaccharide conjugates thereof, suitable for use in immunogenic compositions. |
| FILED | Wednesday, August 09, 2023 |
| APPL NO | 18/447146 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/092 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 47/61 (20170801) A61K 47/646 (20170801) A61K 2039/6087 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Peptides C07K 14/34 (20130101) C07K 14/315 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) C12P 19/14 (20130101) Enzymes C12Y 304/2111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000953 | Bajpayee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ambika Bajpayee (Cambridge, Massachusetts); Chenzhen Zhang (Boston, Massachusetts); Armin Vedadghavami (Boston, Massachusetts); Tengfei He (Malden, Massachusetts) |
| ABSTRACT | The present invention provides a platform for the delivery of small molecule drugs or contrast agents to joints and other soft tissues. The platform enables penetration of the drug through the full thickness of cartilage and long intra-cartilage residence time by leveraging electrostatic interactions between the cationic platform and the anionic cartilage matrix. Described herein are compounds and complexes that fit this platform. Also provided are methods of treating a joint disease with the compounds and complexes of the invention, and methods of imaging joints and other soft tissue. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/310234 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/573 (20130101) A61K 38/18 (20130101) A61K 47/22 (20130101) A61K 47/60 (20170801) Original (OR) Class A61K 47/645 (20170801) A61K 49/0438 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000960 | Lin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Lin (Cleveland, Ohio) |
| ABSTRACT | Provided herein are compositions, systems, kits, and methods for treating a subject having a T-cell mediated disorder, B1-cell mediated disorder, a T-cell lymphoma, or a B-cell lymphoma, with an antibody drug conjugate (ADC) composed of an anti-CD6 antibody (or CD6 binding portion thereof) and a mitotic inhibitor drug (e.g., monomethyl auristatin E (MMAE)). In certain embodiments, the ADC further comprises a cleavable linker (e.g., protease cleavable linker) connecting the antibody component to the mitotic inhibitor drug component. In some embodiments, the subject is a human with autoimmune uveitis or Mantle cell lymphoma. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 18/252928 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6849 (20170801) A61K 47/68031 (20230801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000976 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinsang Kim (Ann Arbor, Michigan); Yingying Zeng (Ann Arbor, Michigan); Do Hyun Kang (Ann Arbor, Michigan); Yannis Paulus (Ann Arbor, Michigan); Van Phuc Nguyen (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are room-temperature phosphorescence nanoparticles, methods of preparing the same, and uses of the same. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 18/039301 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0015 (20130101) Original (OR) Class A61K 49/0093 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 11/025 (20130101) C09K 2211/1007 (20130101) C09K 2211/1018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000977 | Pestell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baruch S. Blumberg Institute (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard G. Pestell (Fort Lauderdale, Florida); Zhiping Li (Wynnewood, Pennsylvania); Xuanmao Jiao (Rockville, Maryland); Anthony Wayne Ashton (Ardmore, Pennsylvania) |
| ABSTRACT | Methods and/or kits for aiding, preventing, treating, or ameliorating the negative effects for a patient suffering from cancer are disclosed herein. In accordance with an aspect of the invention, that includes determining a sensitivity of one or more cancer cells by administering an immunohistochemical stain configured to determine an abundance of DACH1a gene. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 18/032743 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/522 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/4745 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 49/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240001004 | Caliari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Steven R. Caliari (Charlottesville, Virginia); Ivan Basurto (Charlottesville, Virginia) |
| ABSTRACT | A multicompartment conductive collagen scaffold composite, comprising a scaffold comprising collagen and an electrically conductive material, optionally wherein the electrically conductive material comprises electrically conductive particles, and further comprising longitudinally aligned pores, and methods of making and using the same. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 18/037684 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/56 (20130101) Original (OR) Class A61L 27/3826 (20130101) A61L 27/3834 (20130101) A61L 2430/30 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/05 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240001095 | TONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MORNINGSIDE VENTURE INVESTMENTS LIMITED (Monaco, Monaco) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ling-Kang TONG (Hayward, California); Daniela Tamar BUCHMAN (Mountain View, California); Jackie Joe HANCOCK (Berkeley, California); Nicholas TERZULLI (Oakland, California) |
| ABSTRACT | A two-part bioactive agent delivery system includes a disposable part, a reusable part, and a solvent removal element. The disposable part includes an agent reservoir, a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user. The transdermal patch has a bottom surface adapted to contact skin of the user, a top surface opposite the bottom surface, and a gas permeable membrane disposed over the top surface of the transdermal patch. The reusable part includes a power source and control electronics that are adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch. The solvent removal element includes a gap disposed between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178442 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 35/10 (20190501) Original (OR) Class A61M 2205/14 (20130101) A61M 2205/0272 (20130101) A61M 2205/8206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240001120 | Napadow et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vitaly Napadow (Winchester, Massachusetts); Jill M. Goldstein (Newton, Massachusetts); Ronald G. Garcia (Brighton, Massachusetts); Benjamin Pless (Brookline, Massachusetts) |
| ABSTRACT | Systems and methods are provided for neurostimulation timed relative to respiratory activity. Neurostimulation may be delivered to the spinal cord, the vagus nerve, and/or branches of the vagus nerve to provide therapeutic outcomes by controlling or adjusting stimulation based on pulmonary activity. In particular, the systems and methods use a detecting device to detect respiratory activity over time. Specific points in the respiratory signal are identified where central autonomic nuclei may be more receptive to afferent input and a stimulator is instructed to provide neurostimulation to at least one auricular branch of a vagus nerve, or to a cervical branch of the vagus nerve, or to a spinal cord of the subject. In this regard, the neurostimulation is advantageously correlated to the detected respiratory activity providing improved therapeutic outcomes. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/469528 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0502 (20130101) A61N 1/0551 (20130101) A61N 1/36053 (20130101) Original (OR) Class A61N 1/36096 (20130101) A61N 1/36139 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002332 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wenwei Huang (Bethesda, Maryland); Khalida Shamim (Bethesda, Maryland); Hengli Tang (Tallahassee, Florida); The USA, as represented by The Secretary, Dept. of Health and Human Services (Bethesda, Maryland); The Florida State University Research Foundation (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenwei Huang (Bethesda, Maryland); Khalida Shamim (Bethesda, Maryland); Hengli Tang (Tallahassee, Florida) |
| ABSTRACT | The present disclosure relates generally to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), commonly referred to as coronavirus disease 2019 (COVID-19). The present disclosure relates more particularly to small molecule inhibitors of SARS-CoV-2 of Formula (II) and prodrug derivatives thereof of Formula (I), and methods of treating COVID-19 therewith. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 18/253031 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Acyclic or Carbocyclic Compounds C07C 235/84 (20130101) Original (OR) Class Heterocyclic Compounds C07D 209/26 (20130101) C07D 211/46 (20130101) C07D 215/50 (20130101) C07D 277/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002339 | Georg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Moffitt Cancer Center (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ingrid Gunda Georg (Minneapolis, Minnesota); Timothy Ward (Minneapolis, Minnesota); Erik Faber (Minneapolis, Minnesota); Jon E. Hawkinson (Minneapolis, Minnesota); Nan Wang (Minneapolis, Minnesota); Ernst Schonbrunn (Tampa, Florida) |
| ABSTRACT | The invention provides a compound of Formula (I): or a salt thereof, wherein R1-R3, R5-R11, Z, X, and L have any of the values described in the specification, as well as compositions comprising a compound of Formula (I). The compounds are useful as cyclin-dependent kinase 2 (CDK2) inhibitors. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/216497 |
| CURRENT CPC | Heterocyclic Compounds C07D 209/20 (20130101) Original (OR) Class C07D 403/12 (20130101) C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002349 | BOZIK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Biohaven Therapeutics Ltd. (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael E. BOZIK (Wexford, Pennsylvania); Scott S. HARRIED (Sun Prairie, Connecticut); Lynn RESNICK (Pittsburgh, Pennsylvania); George T. TOPALOV (Pittsburgh, Pennsylvania); Justin K. BELARDI (Pittsburgh, Pennsylvania); Charles A. FLENTGE (Mars, Pennsylvania); David A. MARESKA (Pittsburgh, Pennsylvania); James S. HALE (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are optionally substituted benzoimidazol-1,2-yl amides, pharmaceutical compositions comprising a therapeutically effective amount of such compounds and a pharmaceutically acceptable excipient, and methods of treating Kv7 associated diseases, such as, epilepsy, amyotrophic lateral sclerosis, various types of pain, hyperexcitability, a dyskinesia, dystonia, mania and tinnitus with such compounds and pharmaceutical compositions. |
| FILED | Tuesday, June 20, 2023 |
| APPL NO | 18/338096 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4184 (20130101) Heterocyclic Compounds C07D 235/30 (20130101) Original (OR) Class C07D 405/04 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002350 | MORGANROTH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES/DPI/NIH (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sally Ellen MORGANROTH (Pittsburgh, Pennsylvania); Valerian KAGAN (Pittsburgh, Pennsylvania); Jinming ZHAO (Pittsburgh, Pennsylvania); Ganesha RAI (Rockville, Maryland); Hulya BAYIR (Pittsburgh, Pennsylvania); Yulia TYURINA (Pittsburgh, Pennsylvania); Haider DAR (Pittsburgh, Pennsylvania); Tamil ANTHONYMUTHU (Pittsburgh, Pennsylvania); Joel GREENBERGER (Pittsburgh, Pennsylvania); Michael EPPERLY (Pittsburgh, Pennsylvania); Diane LUCI (Okatie, South Carolina); Juan MARUGAN (Gaithersburg, Maryland); Anton SIMEONOV (Bethesda, Maryland); Alexey V. ZAKHAROV (Ijamsville, Maryland); Adam YASGAR (Bethesda, Maryland); Andrew AMOSCATO (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed are compounds and methods for preventing or treating necroinflammation associated with ferroptotic processes. The method includes inhibiting 15 lipoxygenase/phosphatidylethanolamine binding protein (15LOX/PEBP1) complex, wherein the inhibitor exhibits a higher binding affinity or binding activity for 15LOX/PEBP1 complex compared to 15LOX alone. Necroinflammation associated with ferroptotic processes causes several pathogenic conditions including upper or lower respiratory disorders, acute or chronic brain injury, renal injury, injury by radiation, neurodegenerative disorder, among others. The disclosed compounds and methods are useful in subjects diagnosed with one or more of these conditions. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 18/037406 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Acyclic or Carbocyclic Compounds C07C 335/16 (20130101) Heterocyclic Compounds C07D 233/84 (20130101) C07D 233/88 (20130101) C07D 237/20 (20130101) C07D 239/42 (20130101) Original (OR) Class C07D 249/10 (20130101) C07D 263/46 (20130101) C07D 263/48 (20130101) C07D 277/36 (20130101) C07D 277/42 (20130101) C07D 401/04 (20130101) C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002373 | TENG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Blacksmith Medicines, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min TENG (San Diego, California); Baskar NAMMALWAR (San Diego, California); David T. PUERTA (San Diego, California) |
| ABSTRACT | Provided herein is an LpxC inhibitor compound, as well as methods of making and pharmaceutical compositions comprising said compound, and methods of use thereof in the treatment of disease that would benefit from treatment with an LpxC inhibitor, including gram-negative bacterial infections such as urinary tract infections and the like. |
| FILED | Tuesday, June 27, 2023 |
| APPL NO | 18/342321 |
| CURRENT CPC | Heterocyclic Compounds C07D 413/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002395 | Tsukamoto et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Takashi Tsukamoto (Baltimor, Maryland); Barbara Slusher (Baltimore, Maryland); Nlyada Hin (Baltimore, Maryland); Camilo Rojas (Baltimore, Maryland); Xinzhong Dong (Baltimore, Maryland); Yun Guan (Baltimore, Maryland); Ilyas Abdul-Quddoos Berhane (Baltimore, Maryland) |
| ABSTRACT | Positive allosteric modulators (PAMs) of Mas-related G protein-coupled receptor X1 (MRGPRX1) and their use for treating neuropathic pain is disclosed. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 18/255767 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Heterocyclic Compounds C07D 491/048 (20130101) C07D 495/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002396 | Luesch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Smithsonian Institution (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Smithsonian Institution (Washington, District of Columbia) |
| INVENTOR(S) | Hendrik Luesch (Gainesville, Florida); Valerie J. Paul (Fort Pierce, Florida); Susan Matthew (Gainesville, Florida); Qi-Yin Chen (Gainesville, Florida); Ranjala Ratnayake (Gainesville, Florida) |
| ABSTRACT | The instant invention describes macrocyclic compounds having antiproliferation activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 18/030747 |
| CURRENT CPC | Heterocyclic Compounds C07D 498/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002437 | Black et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen M. Black (Tucson, Arizona); Evgeny A. Zemskov (Tucson, Arizona); Qing Lu (Tucson, Arizona) |
| ABSTRACT | It has been discovered that phosphorylation-dependent uncoupling of endothelial nitric oxide synthase (eNOS) plays an important role in endothelial cell (EC) barrier disruption. Compositions and methods to reduce or prevent eNOS uncoupling are disclosed. Decoy peptides that can prevent phosphorylation and mitochondrial redistribution of eNOS, reduce eNOS uncoupling, and preserve EC barrier function, and uses thereof, are described. The peptides improve lung vascular integrity in a mouse model of VILI. Thus, the decoy peptides can be used to treat or prevent diseases or disorders associated with increased vascular permeability such as ALI, ARDS, and VILI. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 18/251078 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 5/1021 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002438 | Haskell-Luevano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); FLORIDA INTERNATIONAL UNIVERSITY (Miami, Florida); NOVA SOUTHEASTERN UNIVERSITY (Fort Lauderdale, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carrie Haskell-Luevano (MINNEAPOLIS, Minnesota); Mark David Ericson (MINNEAPOLIS, Minnesota); Richard A. Houghten (MIAMI, Florida); Clemencia Pinilla (MIAMI, Florida); Marcello Angelo Giulianotti (MIAMI, Florida); Radleigh G. Santos (FORT LAUDERDALE, Florida) |
| ABSTRACT | Certain embodiments of the invention provide a compound of formula (I) or a compound of formula (II): R1—A1—A2—A3—A4—N(R2)2 (I) R3—A5—A6—A7—A8—N(R4)2 (II) or a salt thereof, wherein R1, R2, R3, R4, A1, A2, A3, A4, A5, A6, A7, and A8 are as defined herein, as well as methods of use thereof. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944574 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 5/1016 (20130101) C07K 5/1024 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002442 | Lewis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kim Lewis (Newton, Massachusetts); Ryan Miller (Greenville, Rhode Island); Akira Iinishi (Newton, Massachusetts); Patrick James Lariviere (Cambridge, Massachusetts); Thomas Curtis (Boston, Massachusetts) |
| ABSTRACT | Novel compounds and analogues that exhibit antimicrobial activity—particularly against Gram-negative pathogens—are producible from bacterial isolate Photorhabdus australis DSM 17609 and some related bacterial species of the genus. Pharmaceutical compositions containing the novel compound and its analogues are useful for treating or preventing a bacterial infection. Compounds in accordance herewith include ribosomally produced and post-translationally modified cyclic peptides useful for the treatment, amelioration, and prevention of bacterial infections by Gram-negative pathogens, in addition to other indications. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 18/254459 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002445 | O'Keefe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Barry R. O'Keefe (Frederick, Maryland); Lauren R. Haugh Krumpe (Smithburg, Maryland); Yves Pommier (Bethesda, Maryland); Christophe R. Marchand (Bethesda, Maryland); Ingrid C. Schroeder (Frederick, Maryland); K. Johan Rosengren (Wilston, Australia); Brice A.P. Wilson (Frederick, Maryland) |
| ABSTRACT | Disclosed is a class of knotted cyclic peptides. Related pharmaceutical compositions and methods of using the peptides and methods of synthesizing the peptides are also disclosed. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 18/037379 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/001 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002450 | Bernal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The United States of America, as represented by The Secretary, Department of Health and Human Servi (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Federico Bernal (Gaithersburg, Maryland); Amanda L. Whiting (Dallas, Texas); Loren D. Walensky (Newton, Massachusetts); Gregory H. Bird (Pelham, New Hampshire) |
| ABSTRACT | This disclosure features structurally-stabilized Ebola virus antiviral peptides. Also disclosed are methods of using such structurally-stabilized peptides in the treatment or prevention of an Ebola virus infection or Ebola virus disease. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 18/035427 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/14122 (20130101) C12N 2760/14133 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002459 | Kukar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Kukar (Atlanta, Georgia); Christopher Holler (Arlington, Massachusetts); Georgia Taylor (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to purified and recombinant granulins, fusions, or variants and vectors encoding the same. In certain embodiments, this disclosure relates to uses of these granulins or vectors, alone or in combination, in the treatment or prevention of diseases or conditions associated with lysosomal defects such as frontotemporal dementia and Alzheimer's disease. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176859 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/18 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/475 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002474 | Snyder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Michael P. Snyder (Stanford, California); Andrew Lipchik (Palo Alto, California); Justin Annes (Palo Alto, California); Sooyeon Lee (Santa Clara, California); Anil Narasimha (Stanford, California) |
| ABSTRACT | Systems and methods to assess insulin resistance are described. Further, compounds and methods for treatment of insulin resistance or hyperglycemia are described. In some instances, immunoglobins of an individual are utilized in an insulin-stimulated mitochondrial function assay, which can be utilized to determine insulin resistance. In some instances, glycosylation, including sialylation, of immunoglobins of an individual are assessed, which can be utilized to assess insulin resistance. In some instances, immunoglobins, such as immunoglobin G, are utilized as a treatment for insulin resistance or hyperglycemia. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 18/253198 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 5/50 (20180101) Peptides C07K 16/00 (20130101) Original (OR) Class C07K 2317/41 (20130101) C07K 2317/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002475 | CHAIT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian T. CHAIT (New York, New York); Michael P. ROUT (New York, New York) |
| ABSTRACT | Provided are compositions and methods for producing large repertoires of recombinant single domain antibodies with high affinities and specificities against any antigen. Included are methods for making and identifying single domain antibodies produced by camelids, the single domain antibodies themselves, modifications of the nanobodies, expression vectors encoding the nanobodies, cDNAs encoding the nanobodies, cells comprising the expression vectors and/or cDNA, and methods of making the single domain antibodies re-combinantly Antigen-specific single domain antibodies and antigen binding fragments thereof having a Kd for the antigen in a sub-micromolar range are provided. The use of Protein M in isolating Ag-specific HCAbs, and digesting the isolated HCAbs using IdeS protease, is an aspect of this disclosure. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 18/255043 |
| CURRENT CPC | Peptides C07K 16/00 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6857 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002477 | WILSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Patrick WILSON (Chicago, Illinois); Haley DUGAN (Chicago, Illinois); Christopher STAMPER (Chicago, Illinois); Yoshihiro KAWAOKA (Madison, Wisconsin); Peter HALFMANN (Madison, Wisconsin) |
| ABSTRACT | To address the need in the art, the inventors have comprehensively characterized the SARS-CoV-2-specific B cell repertoire in convalescent COVID-19 patients and generated mAbs against the spike, ORF8, and NP proteins. Together, the inventors' data reveal key insight into antigen specificity and B cell subset distribution upon SARS-CoV-2 infection in the context of age, sex, and disease severity. Aspects of the disclosure relate to novel antibody and antigen binding fragments. Further aspects relate to polypeptides comprising the antigen binding fragment(s) of the disclosure, and compositions comprising the polypeptides, antibodies, and/or antigen binding fragments of the disclosure. Also described are nucleic acids encoding an antibody or antigen binding fragment of the disclosure. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 18/255609 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1003 (20230801) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/92 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002478 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Wilson (Chicago, Illinois); Yaoqing Chen (Chicago, Illinois); Haley L. Dugan (Chicago, Illinois) |
| ABSTRACT | Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335879 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002479 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janet L. Smith (Ann Arbor, Michigan); David L. Akey (Ann Arbor, Michigan); William Clay Brown (Ann Arbor, Michigan); Eva Harris (Oakland, California); Scott B. Biering (Oakland, California); P. Robert Beatty (Oakland, California) |
| ABSTRACT | The disclosure is directed to binding agents, e.g., a single chain variable fragment (scFv) that specifically binds to a flavivirus NS1 protein, as well as compositions comprising the binding agent and a method of using such compositions to induce an immune response against a flavivirus (e.g., a dengue virus). The disclosure also provides a conjugate comprising the binding agent, and a recombinant NS1 antigen. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 18/253886 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Peptides C07K 16/1081 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002480 | Nussenzweig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Michel Nussenzweig (New York, New York); Davide F. Robbiani (New York, New York) |
| ABSTRACT | This disclosure provides novel broadly neutralizing anti-tick-borne encephalitis virus (TBEV) antibodies. The disclosed anti-TBEV antibodies represent a novel therapeutic strategy for preventing or treating diseases or infections caused by various tick-borne flaviviruses, including TBEV. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 18/253981 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1081 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002487 | Han |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yiping Han (Paramus, New Jersey) |
| ABSTRACT | Anti-annexin A1 antibodies are provided and methods of treating FAP and cancer using Anti-annexin A1 antibodies, antibody fragments or fusion proteins, including bispecific antibodies targeting two different annexin A1 epitopes, are also provided. |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/467405 |
| CURRENT CPC | Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002496 | Hendifar |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| INVENTOR(S) | Andrew Hendifar (Santa Monica, California) |
| ABSTRACT | A composition for IL-1 inhibition in combination with cancer therapies (e.g., chemotherapeutics including chemotherapy protective drugs) is provided for use in treating pancreatic cancer cachexia in patients, so as to reduce weight loss and improve the quality of life and survival of the patients. In one embodiment, the IL-1 inhibitor is an antibody, such as bermekimab, anakinra, canakinumab, gevokizumab, or rilonacept, administered simultaneously or sequentially with iritenocan, 5-fluorouracil and folinic acid to a pancreatic cancer patient. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/244459 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/4745 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002528 | Schmiege et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Philip Schmiege (Dallas, Texas); Linda Donnelly (Dallas, Texas); Xiaochun Li (Dallas, Texas) |
| ABSTRACT | Provided herein are compositions, methods and kits for targeting Cystinosin protein. These compositions, methods and kits may be used for detecting and quantifying Cystinosin in clinical and non-clinical samples. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/340608 |
| CURRENT CPC | Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002537 | Eavarone et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seagen Inc. (Bothell, Washington); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Seagen Inc. (Bothell, Washington); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David A. Eavarone (North Quincy, Massachusetts); Jeffrey Behrens (Newton, Massachusetts); Jillian M. Prendergast (Maynard, Massachusetts); Bo R. Rueda (Windham, New Hampshire); Rosemary Foster (Arlington, Massachusetts); Kristen D. Starbuck (Amherst, New York) |
| ABSTRACT | Compositions and methods for treating ovarian cancer are provided. Methods include combined treatment with chemotherapeutic agents and anti-STn antibodies. Chemotherapy resistant ovarian cancer cells may be reduced. Chemotherapy resistant ovarian cancer cells may include cancer stem cells. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 18/053001 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/00 (20130101) A61K 31/337 (20130101) A61K 31/555 (20130101) A61K 33/242 (20190101) A61K 33/243 (20190101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6851 (20170801) A61K 47/6869 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/44 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57449 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002541 | DiNapoli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah DiNapoli (Baltimore, Maryland); Jacqueline Douglass (Baltimore, Maryland); Emily Han-Chung Hsiue (Baltimore, Maryland); Michael S. Hwang (Seattle, Washington); Kenneth W. Kinzler (Baltimore, Maryland); Maximilian Konig (Baltimore, Maryland); Brian J. Mog (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Andrew M. Pardoll (Baltimore, Maryland); Suman Paul (Baltimore, Maryland); Alexander H. Pearlman (Baltimore, Maryland); Bert Vogelstein (Baltimore, Maryland); Shibin Zhou (Owings Mills, Maryland) |
| ABSTRACT | This document relates to methods and materials for treating T cell cancers. For example, a composition containing one or more bispecific molecules can be administered to a mammal having a T cell cancer to treat the mammal. For example, methods and materials for using one or more bispecific molecules to treat a mammal having a T cell cancer are provided. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 18/039403 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/468 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002781 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hsueh-Chia Chang (South Bend, Indiana); Zehao Pan (South Bend, Indiana); Vivek Yadav (South Bend, Indiana); Loan Bui (South Bend, Indiana); Donny Hanjaya-Putra (South Bend, Indiana) |
| ABSTRACT | Described herein is a method for encapsulating single cells using alternating current electrospray technology in tip streaming mode. The encapsulation efficiency is over 80% and natural (alginate, collagen) and synthetic (NorHA) hydrogels and various cell types can be used. The encapsulated cells can be implanted and are protected from the host's immune response. In addition, the coating allows better tissue growth in laboratory cell cultures with a conformal mechanical support that allows molecular and nutrient transport. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 18/039848 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) Original (OR) Class C12N 5/0652 (20130101) C12N 5/0693 (20130101) C12N 13/00 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) C12N 2533/74 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002786 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts); UNIVERSITEIT UTRECHT HOLDING B.V. (Utrecht, Netherlands) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu Shrike Zhang (Bostn, Massachusetts); Tina Vermonden (Utrecht, Netherlands); Cari Schuurmans (Utrecht, Netherlands) |
| ABSTRACT | A method of shrinking a hydrogel is described. The method includes contacting a polyionic hydrogel with a polyionic solution including an ionic polymer having a net opposite charge from that of the polyionic hydrogel for an amount of time sufficient to decrease the volume of the polyionic hydrogel. Hydrogel compositions made using this method, and methods of using these hydrogels in 3D printing are also described. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 18/036924 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/30 (20170801) B29C 64/124 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) B33Y 70/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2533/70 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002799 | SEET et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Christopher S. SEET (Santa Monica, California); Gay Miriam CROOKS (Sherman Oaks, California) |
| ABSTRACT | In various embodiments methods of producing a cell population enriched for CLEC9A+ dendritic cells are provided where the methods involve culturing stem cells and/or progenitor cells in a cell culture comprising culture medium, a notch ligand, stem cell factor (SCF), FLT3 ligand (FLT3L); thrombopoietin (TPO); and IL-3 and/or GMCSF. |
| FILED | Monday, May 08, 2023 |
| APPL NO | 18/313852 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/00115 (20180801) A61K 39/00117 (20180801) A61K 39/001104 (20180801) A61K 39/001106 (20180801) A61K 39/001108 (20180801) A61K 39/001109 (20180801) A61K 39/001122 (20180801) A61K 39/001149 (20180801) A61K 39/001151 (20180801) A61K 39/001153 (20180801) A61K 39/001156 (20180801) A61K 39/001157 (20180801) A61K 39/001164 (20180801) A61K 39/001168 (20180801) A61K 39/001171 (20180801) A61K 39/001172 (20180801) A61K 39/001182 (20180801) A61K 39/001186 (20180801) A61K 39/001188 (20180801) A61K 39/001191 (20180801) A61K 39/001192 (20180801) A61K 39/001193 (20180801) A61K 39/001194 (20180801) A61K 39/001195 (20180801) A61K 39/001197 (20180801) A61K 2039/5154 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) Original (OR) Class C12N 2500/30 (20130101) C12N 2501/22 (20130101) C12N 2501/26 (20130101) C12N 2501/42 (20130101) C12N 2501/125 (20130101) C12N 2501/145 (20130101) C12N 2501/998 (20130101) C12N 2501/2303 (20130101) C12N 2502/1121 (20130101) C12N 2502/1171 (20130101) C12N 2502/1352 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002811 | Roberts et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David D. Roberts (Bethesda, Maryland); Sukhbir Kaur (Bethesda, Maryland); Jeffrey S. Isenberg (Mt. Lebanon, Pennsylvania) |
| ABSTRACT | This disclosure relates to methods of producing induced pluripotent (iPS), multipotent, and/or lineage-committed stem cells from differentiated cells, maintaining iPS, multipotent, and/or lineage-committed cells in culture, and re-differentiating the iPS and multipotent stem cells into any desired lineage-committed cell type. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/320244 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) C12N 5/0647 (20130101) C12N 5/0696 (20130101) Original (OR) Class C12N 2501/599 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002846 | Liedtke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina); Universidad Nacional Autónoma de México (Ciudad de, Mexico); Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wolfgang Liedtke (Durham, North Carolina); Yong Chen (Durham, North Carolina); Tamara Rosenbaum (Ciudad de México, Mexico); Tony Elvern Reeves (Winston-Salem, North Carolina) |
| ABSTRACT | Disclosed herein are compositions and methods for treating a subject having an itch-related disorder, such as dermatological disorders or systemic disorders comprising itch. The methods may include determining the level of a biomarker in a biological sample from the subject. The biomarker may be selected from TRPV4 expression, lysophosphatidylcholine, and miRNA-146a expression, or a combination thereof. The subject may be identified as having the itch-related disorder when the level of the biomarker is greater in a sample from the subject than in a control. An anti-pruritic therapy may be administered to treat the subject having the itch-related disorder. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 18/032103 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6872 (20130101) G01N 33/6893 (20130101) G01N 2500/04 (20130101) G01N 2800/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002848 | Kraemer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES GOVERMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Kraemer (Kent, Washington); Jeanna M. Wheeler (Seattle, Washington); Pamela McMillan (Seattle, Washington); Timothy J. Strovas (Algona, Washington); Jeremy Baker (Seattle, Washington) |
| ABSTRACT | Disclosed herein are small interfering RNA (siRNA) molecules and their use in methods and pharmaceutical compositions for inhibiting the expression of mammalian suppressor of tauopathy 2. Also, described herein are the use of said siRNA molecules in the treatment of Alzheimer's disease or dementia, and reducing accumulation of phosphorylated and aggregated human tau. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 18/038307 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/55 (20130101) A61K 31/445 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002849 | MOOTHA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas); University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas); University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Venkateswara V. MOOTHA (Coppell, Texas); David R. COREY (Dallas, Texas); Jiaxin HU (Coppell, Texas); Jonathan K. WATTS (Worcester, Massachusetts) |
| ABSTRACT | Described are compounds and methods useful in the treatment of Fuchs' Endothelial Corneal Dystrophy (FECD). |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 18/053559 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/7105 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/20 (20170501) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/3231 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002863 | RUIZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ENZERNA BIOSCIENCES, INC. (Morrisville, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph RUIZ (Cary, North Carolina); Zefeng WANG (Shanghai, China PRC) |
| ABSTRACT | The present disclosure provides compositions comprising synthetic site-specific RNA editing entities engineered to target pathogenic RNA comprising a CAG repeat associated with a CAG repeat disorder. Also disclosed herein are methods of treating the CAG repeat disorders of the present disclosure, such as Huntington's disease with the compositions and pharmaceutical formulations comprising the compositions disclosed herein. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/338966 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/117 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002864 | Barna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Maria Barna (Stanford, California); Kathrin Leppek (Stanford, California) |
| ABSTRACT | Systems and methods for enhancing mRNA translation are disclosed. Some embodiments describe expression constructs for producing a peptide and include a translational enhancer. Additional embodiments describe methods for producing a peptide using a construct including a translational enhancer. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/998789 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002882 | Yan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa); University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ziying Yan (Iowa City, Iowa); John F. Engelhardt (Iowa City, Iowa); Jianming Qiu (Overland Park, Kansas) |
| ABSTRACT | A method of preparing a chimeric virus comprising bocavirus capsid protein (VP) and a recombinant adeno-associated (AAV) viral genome, and isolated mutant bocavirus genomes, are provided. |
| FILED | Monday, May 08, 2023 |
| APPL NO | 18/313661 |
| CURRENT CPC | Peptides C07K 14/015 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2800/22 (20130101) C12N 2810/6027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002907 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Thursday, August 24, 2023 |
| APPL NO | 18/455152 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002921 | STENGEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ALIDA BIOSCIENCES, INC. (San Diego, California) |
| ASSIGNEE(S) | ALIDA BIOSCIENCES, INC. (San Diego, California) |
| INVENTOR(S) | Gudrun STENGEL (San Diego, California); Hua YU (San Diego, California); Andrew PRICE (San Diego, California); Jerome SANTOS (San Diego, California); Yu-Hsien HWANG-FU (San Diego, California); Byron PURSE (San Diego, California) |
| ABSTRACT | Provided herein are compositions and methods for the multiplexed profiling of RNA and DNA modifications across transcriptomes and genomes, respectively. The methods combine molecular recognition of non-canonical features (e.g., base modifications, backbone modifications, lesions, and/or structural elements) of a target nucleic acid with a step of writing the information from this recognition event into the neighboring genetic sequence of the target nucleic acid using a barcode. The resultant barcoded nucleic acids are then converted into sequencing libraries and read by DNA/RNA sequencing methods. This step reveals the sequence of the barcode, which is correlated with the non-canonical feature in the target nucleic acid(s). The high throughput profiling methods described herein allow for identification and/or localization of one or more modifications in a target nucleic acid. The methods also allow for identification of the nature and location of several or all DNA/RNA modifications in parallel. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/343014 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6853 (20130101) Original (OR) Class C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002925 | ANSLYN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Eric V. ANSLYN (Austin, Texas); Edward MARCOTTE (Austin, Texas); Cecil J. HOWARD, II (Austin, Texas); Jagannath SWAMINATHAN (Austin, Texas); Angela M. BARDO (Austin, Texas); Brendan FLOYD (Austin, Texas); Brandon HOSFORD (Austin, Texas); Le ZHANG (Austin, Texas); Emily Faith BABCOCK (Austin, Texas); Caroline M. HINSON (Austin, Texas) |
| ABSTRACT | Provided herein are compositions, systems, methods, and kits for peptide analysis, including peptide sequencing. Aspects of the present disclosure provide bifunctional reagents which may selectively couple to amino acids and selectively couple to detectable species. Aspects of the present disclosure further provide methods for using these bifunctional reagents to sequence and analyze peptides. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 18/056970 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002938 | RABINOWITZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Natera, Inc. (San Carlos, California) |
| ASSIGNEE(S) | Natera, Inc. (San Carlos, California) |
| INVENTOR(S) | Matthew RABINOWITZ (San Francisco, California); Milena BANJEVIC (Los Altos Hills, California); Zachary DEMKO (San Francisco, California); David JOHNSON (San Francisco, California); Dusan KIJACIC (Los Altos Hills, California); Dimitri PETROV (Stanford, California); Joshua SWEETKIND-SINGER (San Jose, California); Jing XU (Jersey City, New Jersey) |
| ABSTRACT | Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents. |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/243569 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6827 (20130101) C12Q 1/6855 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 25/00 (20190201) G16B 30/00 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002948 | Diehl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank Diehl (Baltimore, Maryland); Luis Diaz (Ellicott City, Maryland); Kenneth W. Kinzler (Frankford, Delaware); Bert Vogelstein (Baltimore, Maryland); Kerstin Schmidt (Baltimore, Maryland) |
| ABSTRACT | DNA containing somatic mutations is highly tumor specific and thus, in theory, can provide optimum markers. However, the number of circulating mutant gene fragments is small compared to the number of normal circulating DNA fragments, making it difficult to detect and quantify them with the sensitivity required for meaningful clinical use. We apply a highly sensitive approach to quantify circulating tumor DNA (ctDNA) in body samples of patients. Measurements of ctDNA can be used to reliably monitor tumor dynamics in subjects with cancer, especially those who are undergoing surgery or chemotherapy. This personalized genetic approach can be generally applied. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100301 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2525/197 (20130101) C12Q 2535/131 (20130101) C12Q 2549/119 (20130101) C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002956 | DING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF CONNECTICUT (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | XIONG DING (Farmington, Connecticut); CHANGCHUN LIU (Farmington, Connecticut) |
| ABSTRACT | The disclosure provides materials and methods for detection of pathogens. In particular, the disclosure provides primers and compositions for detection of viral pathogens, such as SARS-CoV-2. In addition, the disclosure provides a warm-start digital CRISPR assay for detection of viral pathogens, including SARS-CoV-2. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 18/037361 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003806 | KYUBWA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chromologic LLC (Monrovia, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Espoir KYUBWA (Pasadena, California); Johnathan KNECHT (Rancho Cucamonga, California); Robert CARTLAND (Alhambra, California); Dmitriy ZHUKOV (Baldwin Park, California); Naresh MENON (La Canada Flintridge, California) |
| ABSTRACT | A method of extracting and detecting paramagnetic material in an aqueous medium, the method including: loading a sample into a holder in a cavity enhancement module; directing light from a light source to the sample in the holder; applying an oscillating magnetic field to the sample in the holder; determining a first level of transmittance with the oscillating magnetic field in a first state; determining a second level of transmittance with the oscillating magnetic field in the second state; and determining a change in transmittance of the light from the sample based on the first level of transmittance and the second level of transmittance. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 18/036129 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4055 (20130101) G01N 21/59 (20130101) G01N 21/1717 (20130101) Original (OR) Class G01N 2001/4061 (20130101) G01N 2021/1727 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003847 | Garimella et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Venkata B.S. Garimella (Richland, Washington); Ahmed M. Hamid (Richland, Washington); Yehia M. Ibrahim (West Richland, Washington); Richard D. Smith (Richland, None) |
| ABSTRACT | Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/369045 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/624 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/26 (20130101) H01J 49/0027 (20130101) H01J 49/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003858 | Van Dam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Michael R. Van Dam (Los Angeles, California); Travis S. Holloway (Los Angeles, California); Alejandra Rios (Los Angeles, California); Chelsea Okoro (Los Angeles, California) |
| ABSTRACT | A method of purifying radiochemical species (e.g., radiopharmaceuticals) using thin layer chromatography (TLC) plates includes loading one or more TLC plates with a sample containing the radiochemical species to be purified. The one or more TLC plates are then developed with a mobile phase. The one or more developed TLC plates are then imaged to obtain radioactivity image(s) of the one or more TLC plates. Optional UV images may also be obtained using the same imaging platform. The location of the radiochemical species on the one or more TLC plates is identified from the radioactivity image(s). The radiochemical species on the one or more TLC plates is/are removed at the identified locations. Removal may be accomplished using a mechanical process such as scraping or punching. Alternatively, non-destructive techniques may be employed to remove the radiochemical species from the TLC plate(s). |
| FILED | Friday, October 29, 2021 |
| APPL NO | 18/250911 |
| CURRENT CPC | Separation B01D 15/426 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/3475 (20130101) B01J 20/28035 (20130101) B01J 2220/49 (20130101) B01J 2220/52 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/95 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003867 | Funk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William E. Funk (Evanston, Illinois); Thomas McDade (Evanston, Illinois) |
| ABSTRACT | The present invention provides methods, compositions, kits, and devices for detecting heavy metals in dried blood (e.g., dried blood spots). For example, the present invention provides: 1) dried blood spot paper that is detectably free of heavy metals and methods of preparing such paper using organic acid; 2) dried blood extraction solutions optimized for heavy metal detection (e.g., extraction solutions containing acetic acid and/or gold); 3) methods for estimating venous blood volume from dried blood mass; and 4) kits and kit components optimized for heavy metal detection in dried blood (e.g., kits with paper detectably free of heavy metals, heavy metal free skin wipes, metal free collection case, etc.). |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/469239 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14546 (20130101) A61B 5/15142 (20130101) A61B 5/150022 (20130101) A61B 5/150305 (20130101) A61B 5/150358 (20130101) A61B 5/150755 (20130101) A61B 2562/242 (20130101) A61B 2562/0295 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/49 (20130101) Original (OR) Class G01N 33/84 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003870 | TAYLOR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | METAFORA BIOSYSTEMS (Paris, France); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (Paris, France); UNIVERSITÉ DE MONTPELLIER (Montpellier, France); THE UNITED STATES OF AMERICA ,ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE (Rockville, Maryland) |
| ASSIGNEE(S) | METAFORA BIOSYSTEMS (Paris, France); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (Paris, France); UNIVERSITÉ DE MONTPELLIER (Montpellier, France); THE UNITED STATES OF AMERICA ,ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE (Rockville, Maryland) |
| INVENTOR(S) | Naomi TAYLOR (Washington, District of Columbia); Marie Charlotte Chantal POUZOLLES (Washington, District of Columbia); Valérie DARDALHON (Montpellier, France); Vincent PETIT (Paris, France) |
| ABSTRACT | A method of selecting T cells with improved anti-cancer activity, the method including: a) quantifying glucose transporter 1 (GLUT1) expression level at the cell surface of a population of T cells by using a GLUT1 ligand, b) selecting T cells having a low GLUT1 expression level, wherein the T cells having a low GLUT1 expression level have improved anti-cancer activity. Also, a population of T cells with improved anti-cancer activity for use in the treatment of cancer, to the use of a GLUT1 ligand for selecting T cells with improved anti-cancer activity, and to the use of GLUT1 as a biomarker of the anti-cancer therapeutic efficacy of T cells. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 18/251751 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003884 | Abdel-Mohsen |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohamed Abdel-Mohsen (Wynnewood, Pennsylvania) |
| ABSTRACT | Methods and compositions are provided for the non-invasive diagnosis of likelihood of HIV remission after antiretroviral therapy (ART) interruption, prediction of time-to-viral-rebound in an HIV subject after ART interruption and prediction of the probability of viral rebound in an HIV subject after ART interruption. Methods for treating HIV subjects by increasing or decreasing expression of certain metabolites or glycans are also provided. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 18/251739 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56988 (20130101) Original (OR) Class G01N 2800/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003889 | Eavarone et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seagen Inc. (Bothell, Washington); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Seagen Inc. (Bothell, Washington); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David A. Eavarone (North Quincy, Massachusetts); Julie DeSander (Arlington, Massachusetts); Jeffrey Behrens (Newton, Massachusetts); Bo R. Rueda (Windham, New Hampshire); Rosemary Foster (Arlington, Massachusetts); Kristen D. Starbuck (Amherst, New York) |
| ABSTRACT | The present invention provides methods of testing anti-STn antibodies for their ability target cancer stem cells by isolating cancer stem cells from cultures, contacting them with anti-STn antibodies being tested, and measuring resulting cell viability. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 18/052961 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) A61K 47/6869 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/3069 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003893 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CZ Biohub SF, LLC (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Huang (San Francisco, California); Suraj Makhija (San Francisco, California); David Brown (Oakland, California) |
| ABSTRACT | We have developed the tag-assisted split enzyme complementation (TASEC) approach, which uses two orthogonal small peptide tags and their cognate binders to conditionally drive complementation of a split enzyme upon labeled protein expression. Using this approach, we have engineered and optimized the tag-assisted split HaloTag complementation system (TA-splitHalo) and demonstrated its versatile applications in improving the efficiency of knock-in cell enrichment, detection of protein-protein interaction, and isolation of biallelic gene edited cells through multiplexing. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 18/253718 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/582 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003904 | Wong |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| INVENTOR(S) | Hector R. Wong (Cincinnati, Ohio) |
| ABSTRACT | Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood, vascular, cardiac, and respiratory tract dysfunction, particularly as those responses relate to persistent multiple organ dysfunction syndrome (MODS) in pediatric patients following cardiopulmonary bypass (CPB). Certain aspects of the disclosure relates to identifying one or more biomarkers associated with septic shock in pediatric patients, obtaining one or more samples from a pediatric patient following CPB, then quantifying from the sample an amount of said biomarkers, wherein the level of said biomarker correlates with a predicted outcome. |
| FILED | Tuesday, May 30, 2023 |
| APPL NO | 18/325890 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6869 (20130101) Original (OR) Class G01N 2800/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003905 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Shaopeng WANG (Chandler, Arizona); Rui WANG (Tempe, Arizona); Pengfei ZHANG (Tempe, Arizona) |
| ABSTRACT | Provided herein are methods of modulating temperature in detection fields and producing analyte imaging data. In some embodiments, the methods include introducing an incident light toward a second surface of a substrate to induce a plasmonic wave proximal to a first surface of the substrate such that a temperature in a selected heating space within the detection field is substantially uniformly changed to a selected temperature. Additional methods as well as related systems and computer readable media are also provided. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/212460 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6872 (20130101) Original (OR) Class G01N 33/54386 (20130101) G01N 2333/705 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003908 | Morava-Kozicz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eva Morava-Kozicz (Rochester, Minnesota); Tamas Kozicz (Rochester, Minnesota); Devin Oglesbee (Rochester, Minnesota); Kimiyo M. Raymond (Rochester, Minnesota) |
| ABSTRACT | Methods and materials for assessing the severity of congenital disorders of glycosylation (CDG), as well as methods and materials for treating CDG patients based on the assessment of CDG severity. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 18/036031 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2440/38 (20130101) G01N 2800/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003914 | LASMÉZAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); VOVA IDA THERAPEUTICS, INC. (Jupiter, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Corinne LASMÉZAS (Palm Beach Gardens, Florida); Minghai ZHOU (Jupiter, Florida) |
| ABSTRACT | Methods of preventing disease or treating a subject likely to develop or having a neurodegenerative, degenerative or metabolic disease include administration of nicotinamide dinucleotide (NAD) modulating agents. Compositions include one or more agents which increase or decrease NAD in vivo or in vitro. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 18/252798 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/455 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005179 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rose Yu (Oakland, California); Peter Eckmann (Oakland, California); Kunyang Sun (Oakland, California); Bo Zhao (Oakland, California); Mudong Feng (Oakland, California); Michael K. Gilson (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rose Yu (Oakland, California); Peter Eckmann (Oakland, California); Kunyang Sun (Oakland, California); Bo Zhao (Oakland, California); Mudong Feng (Oakland, California); Michael K. Gilson (San Diego, California) |
| ABSTRACT | Apparatuses, systems, and techniques are described to generate representations of molecules having one or more targeted properties. In one or more examples, an autoencoder can be trained to generate a latent space that represents a number of molecules. The latent space can be used to train a property prediction network that includes a number of property predictors. A latent space optimization process can use the property predictors to identify regions of the latent space that represent molecules having the one or more targeted properties. |
| FILED | Friday, June 16, 2023 |
| APPL NO | 18/336696 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) G16B 15/30 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006016 | Zaballa |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent Zaballa (Irvine, California) |
| ABSTRACT | This disclosure provides methods for optimal inference and design of experiments for mechanistic biological models to identify and/or rank compounds or agents that modulate a targeted cellular biological process to a statistically significant degree. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/217513 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class G16B 15/30 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006050 | SARMA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); University of Pittsburgh- Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Sridevi V. SARMA (McLean, Virginia); Kristin M. GUNNARSDOTTIR (Baltimore, Maryland); Jorge A. GONZALEZ-MARTINEZ (Pittsburgh, Pennsylvania) |
| ABSTRACT | A machine-implemented method, computing device, and at least one non-transitory computer-readable medium are provided. A dynamical network model is parameterized by state transition matrices based on monitored interictal brain data. A node influence-to network score for each respective node is calculated indicating how influential the respective node is. An influenced-by score is calculated for the each respective node indicating an amount by which the respective node is influenced by the nodes. A score is calculated for the each respective node based on a sink index, a source influence index, and a sink connectivity index. Nodes that are in the epileptogenic zone are determined based on the calculated score for each of the nodes. An indication of the nodes in the epileptogenic zone is provided. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 18/255727 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/015 (20130101) A61B 5/4094 (20130101) A61B 5/7267 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) Original (OR) Class G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240000346 | Saha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tamoghna Saha (Raleigh, North Carolina); Orlin D. Velev (Raleigh, North Carolina); Michael D. Dickey (Raleigh, North Carolina); Michael Daniele (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to interstitial fluid (ISF) or extracellular fluid (ECF) harvesting and processing. In one example, a microfluidic monitoring platform includes a microneedle patch including microneedles on a first side; an osmotic patch on a second side of the microneedle patch that includes glycerogel or hydrogel equilibrated with glycerin or glucose; and a microfluidic or fluid transport film or material channel between the osmotic patch and the microneedle patch. The channel can extract fluid from the osmotic-microneedle patch complex. In another example, a wearable electrochemical sensing system includes a monitoring platform including a microneedle-osmotic patch, a microfluidic or fluid transport film or material channel, and at least one sensor between the channel; and processing circuitry coupled to the at least one sensor. The processing circuitry can monitor presence of a chemical or biomarker in the fluid based upon signals obtained from the sensor. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/217392 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1473 (20130101) A61B 5/14514 (20130101) Original (OR) Class A61B 5/14532 (20130101) A61B 5/14539 (20130101) A61B 5/14546 (20130101) A61B 2505/07 (20130101) A61B 2560/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000443 | Labriola et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Visionaire Products, Inc. (Sewickley, Pennsylvania) |
| ASSIGNEE(S) | Visionaire Products, Inc. (Sewickley, Pennsylvania) |
| INVENTOR(S) | Leanne Labriola (Sewickley, Pennsylvania); Rick W. Mental (Villa Park, Illinois); Deana McDonagh (Champaign, Illinois); Thomas Wei (Cary, North Carolina); Alex Gorsuch (Sewickley, Pennsylvania) |
| ABSTRACT | Provided herein are devices and methods for ocular fluid collection with minimal eye displacement, decreased risk of injury to structures in the eye and reduced ocular fluid sample loss. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 18/254915 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0283 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000885 | TANGY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); UNIVERSITEIT UTRECHT HOLDING B.V. (utrecht, Netherlands) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frédéric TANGY (Les Lilsa, France); Pierre-Olivier VIDALAIN (Lyon, France); James R. GOLDENRING (Nashville, Tennessee); Joseph T. Roland (Nashville, Tennessee); Lynne A. LAPIERRE (Nashville, Tennessee); Elizabeth MANNING (Nashville, Tennessee); Cornelis Alexander Maria DE HAAN (Utrecht, Netherlands) |
| ABSTRACT | Disclosed herein is a method for treating or preventing a coronavirus infection in a subject that involves administering to the subject an effective amount of a composition comprising an agent that disrupts the binding of coronavirus membrane glycoprotein (M protein) and Myosin Vb protein (MYO5B). Also disclosed herein is a method for identifying an agent for treating or preventing a coronavirus infection that involves providing a system comprising coronavirus membrane glycoprotein (M protein) and human Myosin Vb protein (MYO5B) with conditions suitable for binding of the M protein and MYO5B; contacting the system with a candidate agent; and assaying the system for binding of M protein and MYO5B. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 18/251497 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 38/162 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000976 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinsang Kim (Ann Arbor, Michigan); Yingying Zeng (Ann Arbor, Michigan); Do Hyun Kang (Ann Arbor, Michigan); Yannis Paulus (Ann Arbor, Michigan); Van Phuc Nguyen (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are room-temperature phosphorescence nanoparticles, methods of preparing the same, and uses of the same. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 18/039301 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0015 (20130101) Original (OR) Class A61K 49/0093 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 11/025 (20130101) C09K 2211/1007 (20130101) C09K 2211/1018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000990 | LIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Metalmark Innovations, PBC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Metalmark Innovations, PBC (Cambridge, Massachusetts) |
| INVENTOR(S) | Sissi LIU (Arlington, Massachusetts); Elijah SHIRMAN (Winchester, Massachusetts); Tanya SHIRMAN (Winchester, Massachusetts) |
| ABSTRACT | An air purification system includes a conduit extending between an inlet and an outlet, each in fluid communication with an enclosed environment. Ambient air from the enclosed environment enters the conduit via the inlet and treated air exits the conduit and enters the enclosed environment via the outlet. The system further includes a fibrous filter disposed within the conduit and configured to treat the ambient air thereby generating the treated air, and a renewal unit disposed within the conduit and configured to renew the fibrous filter. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465463 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 9/16 (20130101) Original (OR) Class A61L 9/205 (20130101) A61L 2209/12 (20130101) A61L 2209/14 (20130101) A61L 2209/21 (20130101) A61L 2209/22 (20130101) A61L 2209/111 (20130101) Separation B01D 39/1607 (20130101) B01D 39/2041 (20130101) B01D 46/0028 (20130101) B01D 46/0036 (20130101) B01D 46/785 (20220101) B01D 2239/0442 (20130101) B01D 2239/0492 (20130101) B01D 2273/30 (20130101) B01D 2279/50 (20130101) B01D 2279/65 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240001136 | CHOA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore County (Baltimore, Maryland); University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fow-Sen CHOA (Baltimore, Maryland); L. Elliott Hong (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to angle-tuned (AT) ring coil devices to reduce the individual coil footprint and improve depth-spread characteristics of transcranial magnetic stimulation (TMS) systems. The AT coil device includes multiple stacked coils, which enhances field strength, reduces the footprint, and increases the field penetration depth by modifying its geometric distribution. Moreover, the AT coil devices demonstrated superior performance for multisite stimulation due to their smaller footprint, making them suitable for multisite stimulations of inter and intra-hemispheric brain regions with an improved spread and less electric field divergence. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345614 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) Original (OR) Class A61N 2/006 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/2823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240001300 | Yarbro et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Molten Salt Solutions, LLC (Santa Fe, New Mexico) |
| ASSIGNEE(S) | Molten Salt Solutions, LLC (Santa Fe, New Mexico) |
| INVENTOR(S) | Stephen L. Yarbro (Corrales, New Mexico); Gordon Dennis Jarvinen (Marana, Arizona); Joe M. Gatewood (Santa Fe, New Mexico); John W. Elling (Santa Fe, New Mexico) |
| ABSTRACT | A composition for extracting a metal, the composition comprising an organic phase comprising a crown either, an organic solvent, and an organic phosphate. The crown either may comprise B15C5 crown and the organic solvent may comprise chloroform and/or toluene. The organic phase may further comprise an alcohol. A method for extracting a metal, the method comprising disposing an organic phase comprising a crown either, an organic solvent, and an organic phosphate; and an aqueous phase comprising a metal salt and a base into a high-speed countercurrent chromatograph. The metal may comprise a lithium ion. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/344396 |
| CURRENT CPC | Separation B01D 59/24 (20130101) Original (OR) Class Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 15/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240001320 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daeyeon Lee (Wynnewood, Pennsylvania); Kathleen J Stebe (Penn Valley, Pennsylvania); Tiancheng Wang (Philadelphia, Pennsylvania) |
| ABSTRACT | This disclosure demonstrates a new method to produce three dimensional multiphasic structures, including bijels, via vapor-induced phase separation (VIPS). In VIPS, the evaporation of the co-solvent from a ternary mixture of oil, water and ethanol, induces phase separation. Particles present in the mixture attach to the interface and arrest the phase separation between water and oil. VIPS enables, inter alia, the fabrication of films and coatings via spreading or spraying particle-laden suspension onto a surface without the need for an outer aqueous phase. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465221 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 23/41 (20220101) B01F 23/48 (20220101) B01F 23/806 (20220101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0065 (20130101) Original (OR) Class B01J 13/0069 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240001964 | Arab et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aliasghar Arab (Piscataway, New Jersey); Jingang Yi (Piscataway, New Jersey) |
| ABSTRACT | Techniques disclosed herein relate to applying a trained constrained Markov decision process (CMDP) to control an autonomous vehicle to perform a stunt maneuver, such as a J-turn, in a safe and agile manner. The CMDP may implement a set of fuzzy logic instructions that correspond to actions needed to execute the stunt maneuver. While training the CMDP, the techniques disclosed herein may utilize a dynamic model of the autonomous vehicle that includes a model of the uncertainty introduced when implementing the stunt maneuver, such as the uncertainty in the tire-road mechanics. By utilizing a worst case scenario measure of the uncertainty during training, safe performance of the stunt maneuver is guaranteed when the trained model is applied in the real world. |
| FILED | Wednesday, June 14, 2023 |
| APPL NO | 18/209943 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/18009 (20130101) B60W 40/06 (20130101) B60W 60/0015 (20200201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002230 | Barsoum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michel Barsoum (Moorestown, New Jersey); Varun Natu (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are methods of stabilizing MXene compositions using polyanionic salts so as to reduce the oxidation of the MXenes. Also provided are stabilized MXene compositions. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/321283 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 21/062 (20130101) C01B 21/076 (20130101) Original (OR) Class C01B 21/0617 (20130101) C01B 21/0637 (20130101) C01B 32/90 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/20 (20130101) C01P 2004/84 (20130101) C01P 2006/40 (20130101) Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black; C09C 1/0006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002261 | CWIERTNY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (lowa City, Iowa); UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | David M. CWIERTNY (Iowa City, Iowa); Nosang V. MYUNG (South Bend, Indiana); Sewoon KIM (Iowa City, Iowa) |
| ABSTRACT | The invention provides a method and materials for removing a metal contaminant from a water sample, as well as composites and methods for making composites. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/215463 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/288 (20130101) Original (OR) Class C02F 2101/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002262 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shangping Xu (Mequon, Wisconsin); Yin Wang (Whitefish Bay, Wisconsin); Jingwan Huo (Shorewood, Wisconsin) |
| ABSTRACT | The present invention is directed at functionalized layered double hydroxides, including methods of their preparation, that are suitable for treatment of water contaminated with per- and polyfluoroalkyl substances. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/215966 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/08 (20130101) B01J 20/223 (20130101) B01J 20/0244 (20130101) B01J 20/0248 (20130101) B01J 20/0296 (20130101) B01J 20/3204 (20130101) B01J 20/3219 (20130101) B01J 20/3257 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/288 (20130101) Original (OR) Class C02F 2101/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002333 | Gong |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bing Gong (Amherst, New York) |
| ABSTRACT | The present disclosure provides linear and cyclic oligoamides. The present disclosure also provides methods of making and uses of linear and cyclic oligoamides. The linear and/or cyclic oliogoamides may be used in methods such as, for example, forming transmembrane pores for transmembrane transport of hydrogen-bond acceptors and/or ions, sequestering hydrogen-bond acceptors and/or ions (e.g., anions), or the like. Compounds of the present disclosure may be used to enrich materials with ions (e.g., lithium). Compounds of the present disclosure may have the following structure: Structure (I) or Structure (II) |
| FILED | Monday, September 13, 2021 |
| APPL NO | 18/044977 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/683 (20130101) Acyclic or Carbocyclic Compounds C07C 237/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002415 | MCNALLY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| INVENTOR(S) | Andrew MCNALLY (Fort Collins, Colorado); Kyle NOTTINGHAM (Fort Collins, Colorado); Chirag PATEL (Fort Collins, Colorado); Jeffrey LEVY (Fort Collins, Colorado); Xuan ZHANG (Fort Collins, Colorado) |
| ABSTRACT | A new set of bench-stable fluoroalkylphosphines that directly convert C—H bonds in pyridine building blocks, drug-like fragments, and pharmaceuticals, into fluoroalkyl derivatives. No pre-installed functional groups or directing motifs are required. The reaction tolerates a variety of sterically and electronically distinct pyridines and is exclusively selective for the 4-position in most cases. The reaction proceeds via initial phosphonium salt formation followed by sp2-sp3 phosphorus ligand-coupling, an underdeveloped manifold for C—C bond formation. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/463878 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 47/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/572 (20130101) Original (OR) Class C07F 9/5022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002780 | Yin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Yadong Yin (Riverside, California); Dilong Liu (Riverside, California) |
| ABSTRACT | A method is disclosed of assembling building blocks into supraparticles. The method includes applying a first solvent on a template of patterned recessed regions to wet surfaces of the recessed regions; applying a second solvent on the template of patterned recessed regions, the building blocks suspended in the second solvent; wherein the first solvent and the second solvent are partially miscible, resulting in negligible interfacial surface tension between the first and second solvents; and wherein droplets of the second solvent diffuse droplets of the first solvent in the recessed regions, thereby assembling the building blocks into the supraparticles in the recessed regions. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 18/252558 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/08 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 9/24 (20130101) B22F 2301/255 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) C01B 33/14 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 7/00 (20130101) C01G 49/02 (20130101) C01G 49/06 (20130101) C01G 49/08 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/10 (20130101) C01P 2002/20 (20130101) C01P 2004/03 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Peptides C07K 14/4732 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0273 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002871 | Simon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Silvec Biologics Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); Silvec Biologics Inc. (Gaithersburg, Maryland) |
| INVENTOR(S) | Anne Elizabeth Simon (Upper Marlboro, Maryland); Changyong Jang (Greenbelt, Maryland); Elizabeth Carino (Alexandria, Virginia); Feng Gao (College Park, Maryland) |
| ABSTRACT | The present disclosure relates to a viral vector suitable for introducing a therapeutic agent, such as a peptide, protein or small RNA, into a host or otherwise treating a host. The vector may include an exogenous RNA segment with a hairpin-like structure or having two or more base-paired regions separated by one or more non-base-paired regions. The exogenous RNA segment may have a secondary structure, minimum free energy, average positional entropy or other attributes within specified ranges, or with values similar to one or more hairpin-like structures of a reference wild type virus. Optionally, the RNA vector may be derived from the reference wild type virus or a relative of the reference wild type virus. In some examples, the vector is capable of capable of systemic and phloem-limited movement and replication within a host plant. In some examples, the reference wild type virus is an umbravirus-like associated RNA. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311495 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8249 (20130101) Original (OR) Class C12N 2796/00 (20220201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002881 | Simon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Silvec Biologics Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); Silvec Biologics Inc. (Gaithersburg, Maryland) |
| INVENTOR(S) | Anne Elizabeth Simon (Upper Marlboro, Maryland); Changyong Jang (Greenbelt, Maryland); Elizabeth Carino (Alexandria, Virginia); Feng Gao (College Park, Maryland) |
| ABSTRACT | The present disclosure relates to a viral vector suitable for introducing a therapeutic agent, such as a peptide, protein or small RNA, into a host or otherwise treating a host. The vector may include an exogenous RNA segment with a hairpin-like structure or having two or more base-paired regions separated by one or more non-base-paired regions. The exogenous RNA segment may have a secondary structure, minimum free energy, average positional entropy or other attributes within specified ranges, or with values similar to one or more hairpin-like structures of a reference wild type virus. Optionally, the RNA vector may be derived from the reference wild type virus or a relative of the reference wild type virus. In some examples, the vector is capable of capable of systemic and phloem-limited movement and replication within a host plant. In some examples, the reference wild type virus is an umbravirus-like associated RNA. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311552 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002907 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Thursday, August 24, 2023 |
| APPL NO | 18/455152 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003403 | Semperlotti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fabio Semperlotti (West Lafayette, Indiana); Mehdi Jokar (Riverside, Rhode Island); Siddharth Nair (West Lafayette, Indiana) |
| ABSTRACT | The vibration attenuation system includes a load bearing layer, a non-load bearing layer, and a rigid beam connector. The load bearing layer has a first density and a first stiffness. The non-load bearing layer has a second density and a second stiffness. The second density is lower than the first density. The rigid beam connector has a third density and a third stiffness. The rigid beam connector couples the load bearing layer to the non-load bearing layer. The coupling of the non-load bearing layer to the load bearing layer is enabled through the use of the rigid beam connector which provides a nonlocal connection to transfer energy from the load bearing layer to the non-load bearing layer. |
| FILED | Saturday, July 01, 2023 |
| APPL NO | 18/217539 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/263 (20130101) B32B 7/022 (20190101) B32B 25/04 (20130101) B32B 27/08 (20130101) B32B 27/40 (20130101) B32B 2307/10 (20130101) B32B 2307/54 (20130101) B32B 2307/72 (20130101) B32B 2307/536 (20130101) Springs; Shock-absorbers; Means for Damping Vibration F16F 13/06 (20130101) F16F 15/022 (20130101) Original (OR) Class F16F 2224/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240004065 | Lal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Geegah LLC (Ithaca, New York) |
| ASSIGNEE(S) | Geegah LLC (Ithaca, New York) |
| INVENTOR(S) | Amit Lal (Ithaca, New York); Justin Kuo (Ithaca, New York); Ivan Bukreyev (Gaithersburg, Maryland) |
| ABSTRACT | An GHz ultrasonic transducer pixel, alone or incorporated into imaging system with a CMOS device. The ultrasonic transducer pixel includes an ultrasonic transducer connected to a transmit circuit and a receive circuit. The transmit and receive circuits are chosen by switches. The ultrasonic transducer pixel also includes a mixer of the receive circuit positioned as a first stage in the receive circuit, a pixel select circuit comprising analog components and digital components, and a power supply conditioning circuitry. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 18/039117 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/5202 (20130101) G01S 7/52026 (20130101) G01S 7/52085 (20130101) G01S 7/52096 (20130101) G01S 15/899 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240004419 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao Wang (Madison, Wisconsin); Nam Sung Kim (Middleton, Wisconsin) |
| ABSTRACT | A computer architecture provides both a parallel memory bus and serial memory bus between a processor system and memory. Latency-tolerant memory access requests are steered to the serial memory bus which operates to increase the available memory bus bandwidth on the parallel memory. The invention also provides integrated circuit computer memory suitable for this application. |
| FILED | Friday, August 04, 2023 |
| APPL NO | 18/230418 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/10 (20130101) Original (OR) Class G06F 3/0635 (20130101) G06F 13/16 (20130101) G06F 13/40 (20130101) G06F 13/42 (20130101) G06F 13/161 (20130101) G06F 13/1663 (20130101) G06F 13/1684 (20130101) G06F 13/4018 (20130101) G06F 13/4234 (20130101) G06F 13/4243 (20130101) G06F 2213/0038 (20130101) G06F 2213/0042 (20130101) G06F 2213/0064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240004542 | Krishnamurthy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinayak Raman Krishnamurthy (West Lafayette, Indiana); Cecil Piya (West Lafayette, Indiana); Karthik Ramani (West Lafayette, Indiana) |
| ABSTRACT | Some examples provides a set of frameworks, process and methods aimed at enabling the expression and exploration of free-form and parametric 3D shape designs enabled through natural interactions with a hand-held mobile device acting as a controller for 3D virtual objects. A reference plane in a virtual space generated by the location of the mobile device may be used to select a 3D virtual object intersected by the reference plane. Positioning of the mobile device may also be used to control a pointer in the virtual space. In an example, the orientation of the mobile device may be detected by an accelerometer or gyroscope. In example, the position of the mobile device may be detected by a position sensor. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/340351 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/017 (20130101) G06F 3/0346 (20130101) G06F 3/04845 (20130101) G06F 3/04883 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 19/006 (20130101) G06T 19/20 (20130101) G06T 2219/2016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240004929 | Miranker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | dataword,Inc. (Austin, Texas) |
| ASSIGNEE(S) | dataword,Inc. (Austin, Texas) |
| INVENTOR(S) | Daniel Paul Miranker (Austin, Texas); Juan Federico Sequeda (Austin, Texas) |
| ABSTRACT | The invention is a system for integrating data sets organized in one organization type with data sets organized in a second organization type so that data queries submitted to be processed in the manner of the first organization type can be translated into queries usable by the data set in the second data organization type and the results returned to satisfy the first query. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855558 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/86 (20190101) Original (OR) Class G06F 16/258 (20190101) G06F 16/8358 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005112 | STANACEVIC et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milutin STANACEVIC (Smithtown, New York); Samir DAS (Melville, New York); Petar DJURIC (Setauket, New York); Athalye AKSHAY (Forest Hills, New York); Ryoo JIHOON (Incheon, South Korea); Yasha KARIMI (Selden, New York) |
| ABSTRACT | A method, system and apparatus are provided for estimating at least one characteristic of a wireless communication channel between at least two passive backscattering radio frequency (RF) nodes, the method including measuring backscatter channel state information (BCSI) during communication between the at least two passive RF nodes; estimating, by at least one RF node of the at least two passive RF nodes, the at least one characteristic of the wireless communication channel based on the measured BCSI. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/469763 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10366 (20130101) Original (OR) Class G06K 19/0723 (20130101) G06K 19/07773 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005162 | FOUDA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Zurich (Zurich, Switzerland); King Abdullah University of Science and Technology (Thuwal, Saudi Arabia); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammed FOUDA (Irvine, California); Emre NEFTCI (Irvine, California); Fadi KURDAHI (Irvine, California); Ahmed ELTAWIL (Irvine, California); Melika PAYVAND (Zurich, Switzerland) |
| ABSTRACT | The present disclosure presents neural network learning systems and methods. One such method comprises receiving an input current signal; converting the input current signal to an input voltage pulse signal utilized by a memristive neuromorphic hardware of a multi-layered spiked neural network module; transmitting the input voltage pulse signal to the memristive neuromorphic hardware of the multi-layered spiked neural network module; performing a layer-by-layer calculation and conversion on the input voltage pulse signal to complete an on-chip learning to obtain an output signal; sending the output signal to a weight update circuitry module; and/or calculating, by the weight update circuitry module, an error signal and based on a magnitude of the error signal, triggering an adjustment of a conductance value of the memristive neuromorphic hardware so as to update synaptic weight values stored by the memristive neuromorphic hardware. Other methods and systems are also provided. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 18/037024 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) G06N 3/084 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005179 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rose Yu (Oakland, California); Peter Eckmann (Oakland, California); Kunyang Sun (Oakland, California); Bo Zhao (Oakland, California); Mudong Feng (Oakland, California); Michael K. Gilson (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rose Yu (Oakland, California); Peter Eckmann (Oakland, California); Kunyang Sun (Oakland, California); Bo Zhao (Oakland, California); Mudong Feng (Oakland, California); Michael K. Gilson (San Diego, California) |
| ABSTRACT | Apparatuses, systems, and techniques are described to generate representations of molecules having one or more targeted properties. In one or more examples, an autoencoder can be trained to generate a latent space that represents a number of molecules. The latent space can be used to train a property prediction network that includes a number of property predictors. A latent space optimization process can use the property predictors to identify regions of the latent space that represent molecules having the one or more targeted properties. |
| FILED | Friday, June 16, 2023 |
| APPL NO | 18/336696 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) G16B 15/30 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005196 | Marandi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Alireza Marandi (Pasadena, California); Rajveer Nehra (Pasadena, California); Ryoto Sekine (Pasadena, California); Luis M. Ledezma (La Crescenta, California) |
| ABSTRACT | A photonic integrated circuit comprising one or more waveguides comprising a second order non-linearity configured to operate on optical pulses each having a pulse length shorter than 1000 optical cycles, as measured at their full width at half maximum. The circuit is configured to generate one or more quantum states carried by one or more of the optical pulses, manipulate one or more of the quantum states, and/or measure one or more of the quantum states. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155444 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) G06N 10/70 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005419 | Shahandashti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohsen Shahandashti (Arlington, Texas); Binaya Pudasaini (Hillsboro, Oregon) |
| ABSTRACT | Systems and methods to identify a rehabilitation policy for water pipe networks are provided. A graph is built to represent a water pipe network including edges for each pipe and nodes for each water source or water user. An approach based on proximity analysis is used to determine the criticality of each node in the graph based on the spatial distribution of water demand type in the neighborhood where the node is located. The spatial variabilities of demand criticalities along with the spatial variabilities of the seismic ground motion intensities are integrated into the formulation of an optimization problem to identify rehabilitation policies the water supply network. A purpose-built simulated annealing algorithm is then used to solve the optimization problem. Results of the optimization may then be used to identify pipes in the water pipe network to replace based on a replacement budget. |
| FILED | Friday, April 28, 2023 |
| APPL NO | 18/308921 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0637 (20130101) G06Q 50/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005976 | Fan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Deliang Fan (Tempe, Arizona); Shaahin Angizi (Orlando, Florida) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Deliang Fan (Tempe, Arizona); Shaahin Angizi (Orlando, Florida) |
| ABSTRACT | A Processing-in-Memory (PIM) design is disclosed that converts any memory sub-array based on non-volatile resistive bit-cells into a potential processing unit. The memory includes the data matrix stored in terms of resistive states of memory cells. Through modifying peripheral circuits, the address decoder receives three addresses and activates three memory rows with resistive bit-cells (i.e., data operands). In this way, three bit-cells are activated in each memory bit-line and sensed simultaneously, leading to different parallel resistive levels at the sense amplifier side. By selecting different reference resistance levels and a modified sense amplifier, a full-set of single-cycle 1-/2-3-input reconfigurable complete Boolean logic and full-adder outputs could be intrinsically readout based on input operand data in the memory array. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/885980 |
| CURRENT CPC | Static Stores G11C 11/161 (20130101) G11C 11/1657 (20130101) G11C 11/1673 (20130101) Original (OR) Class G11C 11/1675 (20130101) Pulse Technique H03K 19/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006129 | LIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Tianran LIU (Princeton, New Jersey); Xiaoming ZHAO (Princeton, New Jersey); Lynn LOO (Princeton, New Jersey) |
| ABSTRACT | Transparent UV-absorbing solar cells are promising for the applications of powering electrochromic windows that regulate the transmission of visible and near-infrared photons for natural lighting and heating purposes, respectively. Current technologies focus on using organic solar cells for the application due to their narrow excitonic absorption and tunable bandgaps. However, transparent organic solar cells have drawbacks including the stability issue and thickness-induced problems, such as low yield rate and limited power conversion efficiency. Disclosed herein is the co-deposition of two or more materials by thermal evaporation to make visibly transparent inorganic perovskite films. By tuning the halide compositions, the inorganic perovskite films show absorption range in UV and near-UV region, which is well-suited to the application. Its high conductivity and absorbance enable it to be around 400 nm thick for devices, which is critical to improve the yield rate and efficiency. The solar cells based on the inorganic perovskite active layers show higher power conversion efficiency and higher transparency than state-of-art UV absorbing solar cells. The disclosed approach is not limited to the exemplary embodiment employing inorganic perovskite, and can employ, e.g., inorganic, organic and hybrid perovskite. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 18/031405 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/20 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0264 (20130101) H01L 31/03928 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006676 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Zheng CHEN (San Diego, California); Panpan XU (San Diego, California) |
| ABSTRACT | A method for restoring electrochemical activity and cycling stability to spent graphite anode material for a lithium-ion battery includes exposing powdered graphite anode material to boric acid to form borated material, then sintering the borated material. The processing removes dead lithium from the bulk structure and applies boron doping to surfaces of the graphite material. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 18/037289 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0471 (20130101) H01M 4/583 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240007300 | Yavuz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Attila A. Yavuz (Tampa, Florida); Saif Eddine Nouma (Lutz, Florida) |
| ABSTRACT | A new series of secure logging schemes that are referred to as Optimal Signatures for secure Logging (OSLO) are created. OSLO schemes are the first AS-based secure logging schemes that achieve small-constant tag and public key sizes with near-optimal signing and batch verification via various granularities. These features make them ideal for IoT-STaaS applications, wherein efficient signing and batch verification are critical for the resource-limited IoTs and cold storage servers, respectively. |
| FILED | Tuesday, June 27, 2023 |
| APPL NO | 18/341901 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240000330 | Ping et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinglei Ping (Amherst, Massachusetts); Xiaoyu Zhang (Amherst, Massachusetts) |
| ABSTRACT | The invention provides devices and methods for measuring microfluidic flow velocity. The novel electrical nanodevice employs a single microelectrode of monolayer graphene and measures in real time at high resolution and stability microfluidic flow velocity by quantifying contact electrification-induced current variations. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/081604 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/026 (20130101) Original (OR) Class A61B 5/6847 (20130101) A61B 2562/12 (20130101) A61B 2562/0285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000587 | Evans et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher O. Evans (Amherst, New Hampshire); Keith D. Violette (Sandown, New Hampshire) |
| ABSTRACT | A system for powering a prosthetic arm is disclosed. The system includes at least one internal battery located in the prosthetic arm, at least one external battery connected to the prosthetic arm, and a master controller configured to connect either the at least one internal battery or the at least one external battery to a power bus to power the prosthetic arm. |
| FILED | Wednesday, September 06, 2023 |
| APPL NO | 18/461605 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/54 (20130101) A61F 2/70 (20130101) Original (OR) Class A61F 2/581 (20130101) A61F 2/585 (20130101) A61F 2002/7862 (20130101) A61F 2220/0075 (20130101) A61F 2250/008 (20130101) A61F 2250/0074 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000694 | GIANNESCHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan C. GIANNESCHI (Wilmette, Illinois); Zofia Elzbieta SIWICKA (Evanston, Illinois); Wei CAO (Evanston, Illinois) |
| ABSTRACT | Aspects disclosed herein include a method for matching hair composition, the method comprising: characterizing one or more first characteristics of a natural melanin composition of a hair sample from a subject; and preparing a prepared artificial melanin formulation to approximate (or, to match or to resemble) the one or more first characteristics; wherein the prepared artificial melanin formulation comprises one or more artificial melanin materials. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/215701 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/0279 (20130101) A61K 8/817 (20130101) Original (OR) Class A61K 2800/43 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 5/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 2333/908 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000726 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); The United States as Represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith T. Wilson (Nashville, Tennessee); John A. Oates (Nashville, Tennessee); Olivier Boutaud (Nashville, Tennessee); Venkataraman Amarnath (Nashville, Tennessee); Erica J. Carrier (Nashville, Tennessee); Alain P. Gobert (Nashville, Tennessee) |
| ABSTRACT | Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein. |
| FILED | Monday, July 10, 2023 |
| APPL NO | 18/220137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/135 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000953 | Bajpayee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ambika Bajpayee (Cambridge, Massachusetts); Chenzhen Zhang (Boston, Massachusetts); Armin Vedadghavami (Boston, Massachusetts); Tengfei He (Malden, Massachusetts) |
| ABSTRACT | The present invention provides a platform for the delivery of small molecule drugs or contrast agents to joints and other soft tissues. The platform enables penetration of the drug through the full thickness of cartilage and long intra-cartilage residence time by leveraging electrostatic interactions between the cationic platform and the anionic cartilage matrix. Described herein are compounds and complexes that fit this platform. Also provided are methods of treating a joint disease with the compounds and complexes of the invention, and methods of imaging joints and other soft tissue. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/310234 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/573 (20130101) A61K 38/18 (20130101) A61K 47/22 (20130101) A61K 47/60 (20170801) Original (OR) Class A61K 47/645 (20170801) A61K 49/0438 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240001358 | Jakubowicz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ortho-Clinical Diagnostics, Inc. (Raritan, New Jersey); The Research Foundation for the State University of New York (Albany, New York); University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond F. Jakubowicz (Rush, New York); Harold Warren (Rush, New York); Benjamin Miller (Rochester, New York); Michael Bryan (Rochester, New York); Daniel Steiner (Rochester, New York); John Cognetti (Rochester, New York); Nathaniel Cady (Delmar, New York); Minhaz Abedin (Jamaica, New York); Natalya Tokranova (Cohoes, New York) |
| ABSTRACT | An apparatus, methods, and a system for a photonic biosensor are disclosed. The photonic biosensor includes a substrate having a sample addition zone in fluid communication with a wicking zone and a sample detection zone. The substrate also includes an optical input port configured to optically couple to a light source and an optical output port configured to optically couple to a light detector. The photonic biosensor also includes a photonic integrated circuit (“PIC”) connected to the substrate. The PIC includes a first grating coupler aligned with the optical input port, a second grating coupler aligned with the optical output port, at least one waveguide between the first grating coupler and the second grating coupler, and at least one detection element disposed within the at least one waveguide. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/585914 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2300/0654 (20130101) B01L 2300/0816 (20130101) Optical Elements, Systems, or Apparatus G02B 6/4215 (20130101) G02B 6/4262 (20130101) G02B 6/29305 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002310 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Haiyang Wang (Riverside, California); Michael R. Zachariah (Riverside, California); Jeffrey S. Moore (Savoy, Illinois); Mayank Garg (Urbana, Illinois) |
| ABSTRACT | An energetic composition and a method of unzipping polymer binders are disclosed, which includes localizing a heat feedback just near the reaction front by unzipping polymer binders employed to a nanothermite. The energetic composition includes an unzipping polymer binder employed to high load fuel and oxidizer particles. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/343137 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 23/00 (20130101) C06B 33/02 (20130101) Original (OR) Class C06B 47/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002380 | Walker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); Pelagos Pharmaceuticals, Inc. (Houston, Texas) |
| ASSIGNEE(S) | Saint Louis University (St. Louis, Missouri); Pelagos Pharmaceuticals, Inc. (Houston, Texas) |
| INVENTOR(S) | John K. Walker (St. Louis, Missouri); Thomas Patrick Burris (Columbia, Illinois); Sadichha Sitaula (Clarksburg, Maryland); Arindam Chatterjee (Ballwin, Missouri); Napoleon Clement D'Cunha (St. Louis, Missouri); Eric Jon Jacobsen (Wildwood, Missouri); James Robert Blinn (O'Fallon, Missouri) |
| ABSTRACT | Disclosed are compounds that regulate REV-ERB nuclear receptors that would be useful for treatment of various diseases. These compounds may be used in therapeutic applications such as in the treatment of neurodegenerative disease such as anxiety disorder, autoimmune diseases or disorders, or muscular disorders such as sarcopenia. |
| FILED | Thursday, April 13, 2023 |
| APPL NO | 18/134055 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 215/227 (20130101) C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002445 | O'Keefe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Barry R. O'Keefe (Frederick, Maryland); Lauren R. Haugh Krumpe (Smithburg, Maryland); Yves Pommier (Bethesda, Maryland); Christophe R. Marchand (Bethesda, Maryland); Ingrid C. Schroeder (Frederick, Maryland); K. Johan Rosengren (Wilston, Australia); Brice A.P. Wilson (Frederick, Maryland) |
| ABSTRACT | Disclosed is a class of knotted cyclic peptides. Related pharmaceutical compositions and methods of using the peptides and methods of synthesizing the peptides are also disclosed. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 18/037379 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/001 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002708 | Tran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ngon T. Tran (Aberdeen, Maryland); Matthew A. Bartucci (Baltimore, Maryland); Joshua A. Orlicki (Havre de Grace, Maryland); Daniel B. Knorr, JR. (Oxford, Pennsylvania); Joseph L. Lenhart (Port Deposit, Maryland) |
| ABSTRACT | Disclosed is a method for improving interfacial adhesion of an adhesive to unprimed substrates and an improved adhesive composition, involving admixing an adhesive with an adhesive modifier, where the modifier is at least partially soluble in the at least one adhesive and includes either a non-aromatic polyol or a molecule having at least one ortho-hydroxyl substitution on a benzene ring. |
| FILED | Monday, July 31, 2023 |
| APPL NO | 18/228174 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 133/04 (20130101) C09J 163/00 (20130101) C09J 175/02 (20130101) C09J 175/04 (20130101) Original (OR) Class C09J 175/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002729 | POPOVIC et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zorana POPOVIC (Boulder, Colorado); Megan C. Robinson (Boulder, Colorado) |
| ABSTRACT | A method for processing waste using pyrolysis reactor include generating a microwave signal; amplifying the microwave signal into a plurality of drive signals; measuring temperature of the waste; determining, based on measured temperature, at least one phase-control signal; and outputting the at least one phase-control signal to maximize power transfer to the waste. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 18/031337 |
| CURRENT CPC | Destructive Distillation of Carbonageous Materials for Production of Gas, Coke, Tar, or Similar Materials C10B 7/10 (20130101) C10B 19/00 (20130101) Original (OR) Class C10B 53/00 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 9/24 (20130101) C10G 2300/1003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002919 | LISSANDRELLO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Charles A. LISSANDRELLO (Natick, Massachusetts); Aditi R. NAIK (Hollis, New Hampshire); Diana J. LEWIS (Cambridge, Massachusetts); Erin ROSENBERGER (Quincy, Massachusetts); Joseph Neil URBAN (Cambridge, Massachusetts); Jason FIERING (Boston, Massachusetts); Caleb R. Bell (Cambridge, Massachusetts); Cait Ni Chleirigh (Cambridge, Massachusetts); Ernest Kim (Cambridge, Massachusetts) |
| ABSTRACT | A removable cartridge to be used in a system for extracting and detecting nucleic acids from heterogeneous samples includes a plurality of reservoirs defining at least a first wash buffer reservoir for holding a first wash buffer and a microfluidic assembly configured to attach to the plurality of reservoirs. The microfluidic assembly includes at least one sample reservoir and a nucleic acid extraction matrix in fluid communication to an automated sample preparation (ASP) reservoir through a first flow channel defined by the microfluidic assembly. An assay chamber is in fluid communication with a third flow channel and with the waste reservoir through a fourth flow channel such that a labeled nucleic acid-containing sample flows through the assay chamber and then to the waste reservoir, wherein vibration-driven mixing agitates fluids while present in the assay chamber. Finally, a nucleic acid-detecting microarray module is positioned in the assay chamber. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/141553 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 7/52 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6851 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002986 | Amram et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Dor Amram (Hod Hasharon, Israel); Christopher A. Schuh (Wayland, Massachusetts) |
| ABSTRACT | Iron-containing alloys, and associated systems and methods, are generally described. The iron-containing alloys are, according to certain embodiments, nanocrystalline. According to certain embodiments, the iron-containing alloys have high relative densities. The iron-containing alloys can be relatively stable, according to certain embodiments. Inventive methods for making iron-containing alloys are also described herein. The inventive methods for making iron-containing alloys can involve, according to certain embodiments, sintering nanocrystalline particulates comprising iron and at least one other element (e.g., at least one other metal or a metalloid) to form an iron-containing nanocrystalline alloy. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/316792 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 2998/10 (20130101) B22F 2999/00 (20130101) Alloys C22C 33/0257 (20130101) C22C 33/0278 (20130101) C22C 38/002 (20130101) Original (OR) Class C22C 38/06 (20130101) C22C 38/008 (20130101) C22C 38/08 (20130101) C22C 38/10 (20130101) C22C 38/12 (20130101) C22C 38/14 (20130101) C22C 38/16 (20130101) C22C 38/18 (20130101) C22C 2200/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003819 | Phan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Standford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thaibao Phan (Redwood City, California); Evan W. Wang (Stanford, California); Jonathan A. Fan (Los Altos, California) |
| ABSTRACT | Certain examples are directed to methods for detection of anomalies in semiconductor thin-film materials, such as strains, defects and the like, that may precipitate defects in semiconductor processing steps and may adversely impact device and system-level functionality, processing, and yields. Certain methods use filtering optics to provide a set of filter-separated light beams respectively associated with different polarization states of polarized light directed towards a semiconductor-related material sample, and providing a set of sample-characterizing response data based on factors such as sets of polarization-state values, different wavelengths associated with the polarization states, and/or light-incidence angles characterizing separation of the different polarization states. Based on these factors, the types and severities of such anomalies may be analyzed and the related defects remedied. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 18/034875 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 4/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) G01N 21/95 (20130101) G01N 21/8422 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003845 | Fury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brewer Science, Inc. (Rolla, Missouri); Department of the Army (Vicksburg, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan J. Fury (Springfield, Missouri); Anton Netchaev (Clinton, Mississippi); Jason Ray (Madison, Mississippi); Keith Conley (Clinton, Mississippi); Eric Brown (Vicksburg, Mississippi) |
| ABSTRACT | In one embodiment, a voltammetry sensor measurement system includes one or more potentiostats configured to transmit an electrical input to a working electrode of a voltammetry sensor and to measure an electrical output from the voltammetry sensor in response to the electrical input, the electrical input including a square wave electrical input, the measured electrical output including a differential current through the working electrode. A controller is coupled with the potentiostats to monitor, in real time, the differential current through the working electrode. The controller is configured to determine if the monitored differential current will exceed a preset differential current threshold of the voltammetry sensor, using a predictive algorithm based on the monitored differential current, before the differential current reaches the threshold; and to generate a signal when the monitored differential current is determined to exceed the threshold, to preserve the voltammetry sensor before the differential current reaches the threshold. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/855866 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/48 (20130101) G01N 27/4163 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003862 | Lavely et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eugene M. Lavely (Concord, Massachusetts); Peter B. Weichman (Bedford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene M. Lavely (Concord, Massachusetts); Peter B. Weichman (Bedford, Massachusetts) |
| ABSTRACT | An underwater sensing system includes a cable structure, a water surface mount coupled to the cable structure, and a processor. The cable structure is configured to be deployed in a vertical orientation underwater and includes one or more sensors along a length of the cable structure. The one or more sensors are configured to detect maritime data associated with one or more marine-based parameters in an underwater maritime region around the cable structure. The water surface mount is configured to be at least partially exposed above a surface of the underwater maritime region and includes a transmitter configured to transmit the maritime data. The processor is configured to access a maritime model comprising parameters associated with the maritime region and update the maritime model based on the maritime data. The maritime model can be used as an input, or otherwise made accessible, to a navigation system of an underwater vehicle. |
| FILED | Tuesday, September 17, 2019 |
| APPL NO | 17/285621 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/4463 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240004263 | Jarrahi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Mona Jarrahi (Los Angeles, California); Deniz Turan (Los Angeles, California); Ping-Keng Lu (Oakland, California) |
| ABSTRACT | Systems and methods for performing wavelength conversion via plasmon-coupled surface states are described that can be used for optical wavelength conversion to different parts of the electromagnetic spectrum ranging from microwave to infrared regimes in both pulsed and continuous wave operation. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 18/255546 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/353 (20130101) Original (OR) Class G02F 2201/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240004417 | Pai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); PoWx inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunil K. Pai (San Jose, California); David A.B. Miller (Stanford, California); Olav Solgaard (Stanford, California); Shanhui Fan (Stanford, California); Michael Dubrovsky (Somerville, Massachusetts); Bogdan Penkovsky (Strassbourg, France); Maynard Marshall Ball, JR. (New York, New York) |
| ABSTRACT | An apparatus for combined digital and optical processing of a cryptocurrency data block includes a digital processor that computes a hash vector from the cryptocurrency data block; a laser and splitter that produces optical input signals; optical modulators that binary phase-shift key modulate the optical input signals based on the hash vector; a photonic matrix multiplier circuit that performs an optically perform a discrete matrix-vector product operation on the modulated optical input signals to produce optical output signals, where the discrete matrix-vector product operation is defined by matrix elements limited to K discrete values, where 2≤K≤17; and photodetectors and comparators that perform optoelectronic conversions of the optical output signals to produce corresponding digital electronic output signals. The digital processor performs a second hash computation on an XOR result between the digital electronic output signals and the hash vector to produce a proof of work result. |
| FILED | Saturday, March 25, 2023 |
| APPL NO | 18/126436 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 3/02 (20130101) Optical Computing Devices; G06E 1/045 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/3827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240004776 | Ogras et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona); Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona); Board of Regents, The University of Texas System (Austin, Texas); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Umit Ogras (Tempe, Arizona); Radu Marculescu (Austin, Texas); Ali Akoglu (Tucson, Arizona); Chaitali Chakrabarti (Tempe, Arizona); Daniel Bliss (Phoenix, Arizona); Samet Egemen Arda (Chandler, Arizona); Anderson Sartor (La Jolla, California); Nirmal Kumbhare (Tucson, Arizona); Anish Krishnakumar (Madison, Wisconsin); Joshua Mack (Tucson, Arizona); Ahmet Goksoy (Madison, Wisconsin); Sumit Mandal (Madison, Wisconsin) |
| ABSTRACT | A user-space emulation framework for heterogeneous system-on-chip (SoC) design is provided. Embodiments described herein propose a portable, Linux-based emulation framework to provide an ecosystem for hardware-software co-design of heterogenous SoCs (e.g., domain-specific SoCs (DSSoCs)) and enable their rapid evaluation during the pre-silicon design phase. This framework holistically targets three key challenges of heterogeneous SoC design: accelerator integration, resource management, and application development. These challenges are addressed via a flexible and lightweight user-space runtime environment that enables easy integration of new accelerators, scheduling heuristics, and user applications, and the utility of each is illustrated through various case studies. A prototype compilation toolchain is introduced that enables automatic mapping of unlabeled C code to heterogeneous SoC platforms. Taken together, this environment offers a unique ecosystem to rapidly perform functional verification and obtain performance and utilization estimates that help accelerate convergence towards a final heterogeneous SoC design. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 18/249885 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5038 (20130101) G06F 11/3414 (20130101) G06F 11/3457 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 7/01 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240004976 | Belenkii et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mikhail Belenkii (San Diego, California); Timothy Brinkley (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mikhail Belenkii (San Diego, California); Timothy Brinkley (San Diego, California) |
| ABSTRACT | A secured personal communication device (SPCD) with iris imaging and retinal scanning designed to provide sensitive or proprietary information when and where it is needed without the possibility for eavesdropping. Sensitive information is transmitted to the user only if the image of the user's iris matches a pre-recorded template of the user's iris. In preferred embodiments a waist mounted fingerprint reader and a RFID/CAC card reader provides additional assurance that transmission of sensitive information is secure. A proximity sensor and waist-mounted communication-control electronic module can also be provided to assure that there is no display of sensitive information to the wearer unless the retinal scanning and iris imaging components are located with the wearer near the eye to which sensitive information is transmitted. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/853165 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/0172 (20130101) G02B 2027/013 (20130101) G02B 2027/014 (20130101) G02B 2027/0138 (20130101) G02B 2027/0141 (20130101) G02B 2027/0178 (20130101) Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005196 | Marandi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Alireza Marandi (Pasadena, California); Rajveer Nehra (Pasadena, California); Ryoto Sekine (Pasadena, California); Luis M. Ledezma (La Crescenta, California) |
| ABSTRACT | A photonic integrated circuit comprising one or more waveguides comprising a second order non-linearity configured to operate on optical pulses each having a pulse length shorter than 1000 optical cycles, as measured at their full width at half maximum. The circuit is configured to generate one or more quantum states carried by one or more of the optical pulses, manipulate one or more of the quantum states, and/or measure one or more of the quantum states. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155444 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) G06N 10/70 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005654 | Ray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arijit Ray (Princeton, New Jersey); Michael A. Cogswell (West Windsor, New Jersey); Ajay Divakaran (Monmouth Junction, New Jersey); Yi Yao (Princeton, New Jersey); Giedrius T. Burachas (Princeton, New Jersey); Kamran Alipour (San Diego, California) |
| ABSTRACT | A computing system comprising a memory configured to store an artificial intelligence (AI) model and an image, and a computation engine executing one or more processors may be configured to perform the techniques for error-based explanations for AI behavior. The computation engine may execute the AI model to analyze the image to output a result. The AI model may, when analyzing the image to output the result, process, based on data indicative of the result, the image to assign an error score to each image feature extracted from the image, and obtain, based on the error scores, an error map. The AI model may next update, based on the error map and to obtain a first updated image, the image to visually indicate the error score assigned to each of the image features, and output one or more of the error scores, the error map, and the first updated image. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/656391 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 11/001 (20130101) Image or Video Recognition or Understanding G06V 10/98 (20220101) Original (OR) Class G06V 10/776 (20220101) G06V 10/7715 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006430 | Zhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rui Zhu (Princeton, New Jersey); Peter alan Levine (West Windsor, New Jersey); John Robertson Tower (Poinciana, Florida) |
| ABSTRACT | An image sensor having a set of pixels making up the image sensor to capture an image. Two or more pixels in the set of pixels each have an architecture that includes multiple photodiodes configurable to form an individual pixel. A control system can cooperate with the multiple photodiodes to form the individual pixel. Each of the multiple photodiodes can have a transfer gate electrically coupled to that photodiode. A common region can hold or transfer charge at least during or after an integration time. A read gate electrically coupled to the common region and a sense node, can supply charge from the common region through the read gate to the sense node. |
| FILED | Thursday, September 03, 2020 |
| APPL NO | 17/764087 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14603 (20130101) H01L 27/14614 (20130101) Original (OR) Class H01L 27/14641 (20130101) Pictorial Communication, e.g Television H04N 25/57 (20230101) H04N 25/533 (20230101) H04N 25/583 (20230101) H04N 25/771 (20230101) H04N 25/778 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006643 | Glaven et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah M. Glaven (Washington, District of Columbia); Lina Bird (Washington, District of Columbia); Leonard M. Tender (Bethesda, Maryland) |
| ABSTRACT | “Biocathode MCL,” designated for its main bacterial constituents (Marinobacter, Chromatiaceae, and Labrenzia), is a stable microbial community enriched from seawater that forms biofilms on the surfaces of electrodes. These biofilms are effective to perform carbon fixation without the need for external electrical power nor sunlight applied thereto. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/369547 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/34 (20130101) C02F 11/02 (20130101) Apparatus for Enzymology or Microbiology; C12M 25/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240007075 | Tabrizian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roozbeh Tabrizian (Gainesville, Florida); Dicheng Mo (Gainesville, Florida); Shaurya Dabas (Gainesville, Florida); Sushant Rassay (Gainesville, Florida) |
| ABSTRACT | A laminated ScxAl1-xN BAW resonator with complementary-switchable operation in thickness extensional modes (TEl and TEN). The resonator comprises ferroelectric ScxAl1-xN layers alternatively stacked with metal electrodes, enabling independent polarization switching of each piezoelectric layer. Opting for unanimous or alternative poling of the ScxAl1-xN layers, the resonator can be switched to operate in two complementary states with either TEl or TEN active resonance modes of similarly large kt2. |
| FILED | Monday, June 26, 2023 |
| APPL NO | 18/341114 |
| CURRENT CPC | Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/02015 (20130101) H03H 9/02047 (20130101) H03H 9/02062 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240007186 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Runzhou Zhang (Los Angeles, California); Nanzhe Hu (Los Angeles, California); Alan E. Willner (Los Angeles, California); Huibin Zhou (Los Angeles, California); Haoqian Song (Los Angeles, California); Hao Song (Los Angeles, California); Xinzhou Su (Los Angeles, California); Kaiheng Zou (Los Angeles, California) |
| ABSTRACT | Atmospheric turbulence degrades decoding and data recovery from optically transmitted signals. For example, atmospheric turbulence can induce power coupling from the transmitted Gaussian mode to higher-order modes, resulting in significantly degraded mixing efficiency and system performance. Systems and methods are provided to generate a signal that is a conjugate of the atmospheric noise which is combined with a received data signal to ameliorate atmospheric noise. An optical pilot beam may be transmitted with an optical data beam and received by a receiver which utilizes the optical pilot beam to generate the signal that is a conjugate of the atmospheric noise. |
| FILED | Thursday, January 20, 2022 |
| APPL NO | 18/267731 |
| CURRENT CPC | Transmission H04B 10/615 (20130101) H04B 10/1121 (20130101) Original (OR) Class H04B 10/5161 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240007408 | Basu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prithwish Basu (Westford, Massachusetts); Christophe Jean-Claude Merlin (Wakefield, Massachusetts); Owen Hope (Somerville, Massachusetts) |
| ABSTRACT | According to at least one aspect of the present disclosure, a method for determining whether two flows are related is provided. The method comprises identify a first flow; identify a second flow; collect one or more attributes of one or more packets of the first flow and second flow during an interval of time; determine a flow similarity of the first flow and the second flow based on the one or more attributes; determine that the flow similarity exceeds a similarity threshold; and responsive to determining that the flow similarity exceeds a similarity threshold, determine that the first flow and second flow are related flows. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169634 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 47/2441 (20130101) Original (OR) Class H04L 47/2483 (20130101) H04L 47/2491 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240000956 | De et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kuntal De (Oak Ridge, Tennessee); Wellington Muchero (Oak Ridge, Tennessee); Debjani Pal (Knoxville, Tennessee) |
| ABSTRACT | The present disclosure is directed to methods for modulating protein function through attaching a PAN domain or a functional fragment thereof to a target protein thereby promoting internalization and degradation of the target protein, wherein the target protein does not comprise a native PAN domain. Another aspect of the current disclosure is directed to a method of inhibiting the internalization of a targeted extracellular protein wherein the targeted extracellular protein comprises a PAN domain. |
| FILED | Thursday, May 25, 2023 |
| APPL NO | 18/323672 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240001258 | SINGH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Vijay SINGH (Champaign, Illinois); Shivali BANERJEE (Urbana, Illinois); Erik SACKS (Urbana, Illinois) |
| ABSTRACT | Miscanthus x giganteus is a widely recognized bioenergy crop that finds potential applications in a biorefinery for the production of a wide range of biofuels and biochemicals. This disclosure focuses upon the quantification of the total anthocyanin concentration in miscanthus. Hydrothermal pretreatment was studied for recovering anthocyanins in the pretreatment liquor. The optimized pretreatment conditions (170° C., 10 min) led to a recovery of 94.3±1.5% w/w of the total anthocyanin concentration and also improved the enzymatic digestibility of the biomass, allowing recovery of 70.6±0.5% w/w of glucose at the end of 72 h of enzymatic saccharification. The sugar monomers obtained after the enzymatic hydrolysis of the pretreated biomass could be used for the production of biofuels or biochemicals in an integrated biorefinery. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345309 |
| CURRENT CPC | Separation B01D 11/0288 (20130101) Original (OR) Class B01D 2257/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2437 (20130101) Enzymes C12Y 302/01004 (20130101) Saccharides Obtained From Natural Sources or by Hydrolysis of Naturally Occurring Disaccharides, Oligosaccharides or Polysaccharides C13K 1/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002227 | MERRILL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LUNA INNOVATIONS INCORPORATED (Roanoke, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew MERRILL (Roanoke, Virginia); Greg SIMMS (Roanoke, Virginia) |
| ABSTRACT | Processes are provided which pyrolytically extract hydrochloric acid from a magnesium ion-rich salt mixture. In this regard, a supply of the magnesium ion-rich salt mixture (e.g., bittern) may be directed to a pyrolytic chamber where it is contacted with heated gas (e.g., combustion flue gas) at a sufficient temperature and for a sufficient time to form a vapor product stream comprised of hydrochloric acid and an insoluble pyrolyzed mixed salt stream comprised of magnesium hydroxide and sodium sulfate decahydrate. The solid pyrolyzed mixed salt stream may be separated into separate product streams comprising the insoluble magnesium hydroxide and remaining soluble salt fractions, while the vapor product stream of hydrochloric acid from the pyrolytic chamber may be condensed form an aqueous HCl solution. The magnesium ion rich salt mixture may be dehydrated prior to pyrolysis to achieve magnesium ions in a tetrahydrate state or lower (e.g., a monohydrate to a trihydrate state). |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 18/255561 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 7/0737 (20130101) Original (OR) Class Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 3/08 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 5/305 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002339 | Georg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Moffitt Cancer Center (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ingrid Gunda Georg (Minneapolis, Minnesota); Timothy Ward (Minneapolis, Minnesota); Erik Faber (Minneapolis, Minnesota); Jon E. Hawkinson (Minneapolis, Minnesota); Nan Wang (Minneapolis, Minnesota); Ernst Schonbrunn (Tampa, Florida) |
| ABSTRACT | The invention provides a compound of Formula (I): or a salt thereof, wherein R1-R3, R5-R11, Z, X, and L have any of the values described in the specification, as well as compositions comprising a compound of Formula (I). The compounds are useful as cyclin-dependent kinase 2 (CDK2) inhibitors. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/216497 |
| CURRENT CPC | Heterocyclic Compounds C07D 209/20 (20130101) Original (OR) Class C07D 403/12 (20130101) C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002787 | BRIGMON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ROBIN L. BRIGMON (NORTH AUGUSTA, South Carolina); ALEX J. KUGLER (AIKEN, South Carolina); CORY L. TRIVELPIECE (AIKEN, South Carolina) |
| ABSTRACT | Solid, porous, glass-based substrate for storage and delivery of useful microorganisms are described. Materials include one or more microorganisms lyophilized on the substrate, e.g., in the form of a lyophilized biofilm. The materials can be utilized for long-term storage, transport, and deployment of one or more microorganisms, such as consortium of microorganisms at a remediation site. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855141 |
| CURRENT CPC | Reclamation of Contaminated Soil B09C 1/10 (20130101) B09C 1/105 (20130101) B09C 2101/00 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/322 (20130101) C02F 3/343 (20130101) C02F 3/347 (20130101) C02F 2101/32 (20130101) C02F 2305/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) Original (OR) Class C12N 2533/12 (20130101) C12N 2533/14 (20130101) C12N 2535/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002865 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Akos Nyerges (Boston, Massachusetts) |
| ABSTRACT | Methods making and using genomically recoded cells or organisms are provided including genomically recoded cells or organisms that lack the ability to translate a foreign nucleic acid sequence into a polypeptide that may be toxic to the genomically recoded cell or organism. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 18/255160 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002876 | Lofstedt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jan Christer Lofstedt (Lund, Sweden); Per Fredrik Hofvander (Bjarred, Sweden); Honglei Wang (Lund, Sweden); Baojian Ding (Lund, Sweden); Yihan Xia (Lund, Sweden); Carin Ingegerd Jarl-Sunesson (Lund, Sweden); Board of Regents of the University of Nebraska (Lincoln, Nebraska); ISCA Technologies, Inc. (Riverside, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jan Christer Lofstedt (Lund, Sweden); Per Fredrik Hofvander (Bjarred, Sweden); Baojian Ding (Lund, Sweden); Yihan Xia (Lund, Sweden); Honglei Wang (Lund, Sweden); Carin Ingegerd Jarl-Sunesson (Lund, Sweden); Edgar Benjamin Cahoon (Lincoln, Nebraska); Agenor Mafra-Neto (Riverside, California) |
| ABSTRACT | The present disclosure relates to methods of producing insect pheromone precursors and genetically modified plants capable of producing insect pheromone precursors. The genetically modified plants include a heterologous gene encoding at least one silencing suppressor protein and at least one enzyme selected from the group consisting of a fatty acyl desaturase, a fatty acyl elongase, a fatty acyl reductase, and an acyl-CoA oxidase. |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/467279 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8247 (20130101) C12N 15/8286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003396 | Rueger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachariah Rueger (Overland Park, Kansas); Amer Sadikovic (Ballwin, Missouri) |
| ABSTRACT | A lattice structure and system for absorbing energy, damping vibration, and reducing shock. The lattice structure comprises a plurality of unit cells, each unit cell comprising a plurality of rib elements with at least a portion of the rib elements including a solid bendable hinge portion for converting energy into linear motion along a longitudinal axis of the respective rib element. |
| FILED | Monday, August 07, 2023 |
| APPL NO | 18/366030 |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 3/023 (20130101) Original (OR) Class F16F 7/121 (20130101) F16F 7/123 (20130101) F16F 15/073 (20130101) F16F 2224/0208 (20130101) F16F 2230/34 (20130101) F16F 2238/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003836 | Fuka et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Microbeam Technologies, Inc. (Grand Forks, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Fuka (Grand Forks, North Dakota); Eric Kolb (Grand Forks, North Dakota); Alexander Benson (Denver, Colorado); Steven Benson (Victoria, Minnesota) |
| ABSTRACT | A system for predicting rare earth elements (REEs) in a feedstock sample includes a measurement instrument that records a measurement for a sample, a processor communicatively coupled to the measuring instrument, and a memory communicatively coupled to the processor and containing machine readable instructions that, when executed by the processor, cause the processor to correlate the measurement series using a model; and predict a presence of one or more rare earth element based at least in part on the correlation. A method for predicting rare earth elements includes measuring feedstock samples via XRF or PGNAA, to generate a measurements of elements of interest with a lower atomic weight than REEs; correlating the measurements with a model; and predicting a presence of one or more rare earth elements based at least in part on the correlation. |
| FILED | Thursday, July 06, 2023 |
| APPL NO | 18/347826 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/222 (20130101) Original (OR) Class G01N 23/223 (20130101) G01N 33/2858 (20130101) G01N 2223/076 (20130101) G01N 2223/301 (20130101) G01N 2223/305 (20130101) G01N 2223/616 (20130101) G01N 2223/617 (20130101) G01N 2223/0745 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003847 | Garimella et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Venkata B.S. Garimella (Richland, Washington); Ahmed M. Hamid (Richland, Washington); Yehia M. Ibrahim (West Richland, Washington); Richard D. Smith (Richland, None) |
| ABSTRACT | Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/369045 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/624 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/26 (20130101) H01J 49/0027 (20130101) H01J 49/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240004065 | Lal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Geegah LLC (Ithaca, New York) |
| ASSIGNEE(S) | Geegah LLC (Ithaca, New York) |
| INVENTOR(S) | Amit Lal (Ithaca, New York); Justin Kuo (Ithaca, New York); Ivan Bukreyev (Gaithersburg, Maryland) |
| ABSTRACT | An GHz ultrasonic transducer pixel, alone or incorporated into imaging system with a CMOS device. The ultrasonic transducer pixel includes an ultrasonic transducer connected to a transmit circuit and a receive circuit. The transmit and receive circuits are chosen by switches. The ultrasonic transducer pixel also includes a mixer of the receive circuit positioned as a first stage in the receive circuit, a pixel select circuit comprising analog components and digital components, and a power supply conditioning circuitry. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 18/039117 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/5202 (20130101) G01S 7/52026 (20130101) G01S 7/52085 (20130101) G01S 7/52096 (20130101) G01S 15/899 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240004263 | Jarrahi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Mona Jarrahi (Los Angeles, California); Deniz Turan (Los Angeles, California); Ping-Keng Lu (Oakland, California) |
| ABSTRACT | Systems and methods for performing wavelength conversion via plasmon-coupled surface states are described that can be used for optical wavelength conversion to different parts of the electromagnetic spectrum ranging from microwave to infrared regimes in both pulsed and continuous wave operation. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 18/255546 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/353 (20130101) Original (OR) Class G02F 2201/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005248 | Gupta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhinav Gupta (Raleigh, North Carolina); Saran Srikanth Bodda (Raleigh, North Carolina); Pragya Vaishanav (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure presents control systems and related methods for accurate estimation of a system-level risk. One such method comprises obtaining, via at least one of one or more computing devices, a tree data structure of a system-level failure risk of a system plant, wherein a binary state failure probability of an internal node in the tree data structure is a function of its logic gate connection and its child nodes; where the tree data structure has only independent nodes, computing a binary state failure probability of a failure event represented as a top node of the tree data structure; where the tree data structure has multiple dependent chains having a common dependent node, evaluating, the binary state failure probability of each dependent chain separately; and outputting the binary state failure probability for the failure event represented as the top node of the tree data structure. |
| FILED | Monday, May 08, 2023 |
| APPL NO | 18/313860 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0635 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006130 | Martini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FastCAP Systems Corporation (Wakefield, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fabrizio Martini (Boston, Massachusetts); Riccardo Signorelli (The Woodlands, Texas); John J. Cooley (Boston, Massachusetts); Christopher John Sibbald Deane (Boston, Massachusetts); James Epstein (Sharon, Massachusetts); Padmanaban Sasthan Kuttipillai (Malden, Massachusetts); Lindsay A. Wilhelmus (Lexington, Kentucky) |
| ABSTRACT | An ultracapacitor that includes an energy storage cell immersed in an advanced electrolyte system and disposed within a hermetically sealed housing, the cell electrically coupled to a positive contact and a negative contact, wherein the ultracapacitor is configured to output electrical energy within a temperature range between about −40 degrees Celsius to about 210 degrees Celsius. Methods of fabrication and use are provided. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/369267 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/30 (20130101) Original (OR) Class H01G 11/34 (20130101) H01G 11/36 (20130101) H01G 11/52 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0563 (20130101) H01M 10/0568 (20130101) H01M 50/423 (20210101) H01M 50/426 (20210101) H01M 50/437 (20210101) H01M 50/491 (20210101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006390 | MURIALDO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maxwell MURIALDO (Westminster, California); Yuliya KANARSKA (Livermore, California); Andrew J. PASCALL (Livermore, California) |
| ABSTRACT | The present disclosure relates to a method for forming an electrically conductive ink able to be deposited through a print nozzle during a 3D printing operation. The method may involves providing an electrically non-conductive flowable material adapted to be flowed through a print nozzle during a 3D printing operation. A predetermined quantity of chiplets may then be mixed into flowable material, in accordance with a predefined percolation threshold, to form a percolating chiplet network within the polymer as the ink is flowed through the print nozzle and deposited on a surface. The chiplets each form an engineered electronic component, and ones of the chiplets randomly connect, in accordance with the predefined percolation threshold, to form an electrically conductive circuit having a predetermined circuit characteristic. |
| FILED | Thursday, August 17, 2023 |
| APPL NO | 18/451234 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 25/07 (20130101) H01L 25/16 (20130101) Original (OR) Class H01L 25/50 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/16 (20130101) H05K 3/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006611 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krystal Lee (Binghamton, New York); Carrie Siu (Darien, Illinois); Fengxia Xin (Vestal, New York); M. Stanley Whittingham (Vestal, New York) |
| ABSTRACT | A lithium battery with a cathode fabricated using an improved method for slurry formulation and electrode production. The cathode comprises the epsilon polymorph of vanadyl phosphate, ε-VOPO4, made from solvothermally synthesized H2VOPO4, and optimized to reversibly intercalate two Li-ions to reach full theoretical capacity with a coulombic efficiency of 98%. This material adopts a stable 3D tunnel structure and can extract two Li-ions per vanadium ion, giving a theoretical capacity of 305 mAh/g, with an upper charge/discharge plateau at around 4.0 V, and one lower at around 2.5 V. The ε-VOPO4 particles may be modified with niobium (Nb) to improve the cycling stability. |
| FILED | Wednesday, August 09, 2023 |
| APPL NO | 18/447267 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 25/372 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/136 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 4/1397 (20130101) H01M 4/5825 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006612 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krystal Lee (Binghamton, New York); Carrie Siu (Darien, Illinois); Fengxia Xin (Vestal, New York); M. Stanley Whittingham (Vestal, New York) |
| ABSTRACT | A lithium battery with an improved cathode. The cathode comprises the epsilon polymorph of vanadyl phosphate, ε-VOPO4, made from solvothermally synthesized H2VOPO4, and optimized to reversibly intercalate two Li-ions to reach full theoretical capacity with a coulombic efficiency of 98%. This material adopts a stable 3D tunnel structure and can extract two Li-ions per vanadium ion, giving a theoretical capacity of 305 mAh/g, with an upper charge/discharge plateau at around 4.0 V, and one lower at around 2.5 V The ε-VOPO4 particles may be modified with niobium (Nb) to improve the cycling stability. |
| FILED | Wednesday, August 09, 2023 |
| APPL NO | 18/447278 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 25/372 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/136 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 4/1397 (20130101) H01M 4/5825 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006664 | Hawks |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. Hawks (Livermore, California) |
| ABSTRACT | Energy storage apparatus, systems, and methods provide an energy storage enclosure, a negative electrode in the enclosure, a positive electrode in the enclosure, a separator between the negative electrode and the positive electrode, an electrolyte in the enclosure, and the circulation of the electrolyte through the negative electrode and the positive electrode. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/809983 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0566 (20130101) H01M 10/4214 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006675 | Tanim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (ldaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tanvir R. Tanim (Idaho Falls, Idaho); Bor-Rong Chen (Idaho Falls, Idaho); Matthew R. Kunz (Idaho Falls, Idaho); Eric J. Dufek (Ammon, Idaho) |
| ABSTRACT | Various embodiments relate to determining a lithium-plating state of a battery. Various embodiments include a method including: observing a first characteristic of a battery, observing a second characteristic of the battery, and determining, based on the first characteristic and the second characteristic, a lithium-plating state of the battery. In some embodiments, the first characteristic and the second characteristic may each be one of: a rate of change of the capacity per cycle over a number of cycles, end-of-charge rest voltage over a number of cycles, and a coulombic efficiency over a number of cycles. Related devices are also disclosed. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 18/253194 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/425 (20130101) H01M 10/484 (20130101) Original (OR) Class H01M 2010/4271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006676 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Zheng CHEN (San Diego, California); Panpan XU (San Diego, California) |
| ABSTRACT | A method for restoring electrochemical activity and cycling stability to spent graphite anode material for a lithium-ion battery includes exposing powdered graphite anode material to boric acid to form borated material, then sintering the borated material. The processing removes dead lithium from the bulk structure and applies boron doping to surfaces of the graphite material. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 18/037289 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0471 (20130101) H01M 4/583 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006890 | CAVRARO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guido CAVRARO (Littleton, Colorado); Manish Kumar SINGH (Minneapolis, Minnesota) |
| ABSTRACT | A device may calculate a reactive power setpoint associated with a distributed energy resource (DER) electrically coupled to a power distribution network, based on a local voltage value associated with the DER. The device may control a reactive power output of the DER in association with regulating voltage at the power distribution network, based on the reactive power setpoint. |
| FILED | Tuesday, June 20, 2023 |
| APPL NO | 18/337578 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/16 (20130101) H02J 3/381 (20130101) Original (OR) Class H02J 2203/10 (20200101) H02J 2203/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240000572 | WILLIAMS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dustin L. WILLIAMS (Salt Lake City, Utah); Richard Tyler EPPERSON (Salt Lake City, Utah); Brad M. ISAACSON (Salt Lake City, Utah); Brooke KAWAGUCHI (Salt Lake City, Utah); Mary Grace CANAPI (Salt Lake City, Utah) |
| ABSTRACT | A bone cap (100) for preventing leakage of medullary canal components in a residual limb (102) that can lead to pathologies such as heterotopic ossification reducing heterotopic ossification and a method for using the same are provided. The bone cap (100) includes a proximal base (114) and an insertion extension portion (116) extending from the proximal base (114). The insertion extension portion (116) has an outer surface and a distal end (112b) opposite the proximal base (114). The insertion extension portion (116) is configured to be inserted into a resected portion of a bone (104) of a patient. The bone cap (100) also has at least one bone engaging feature (120) disposed on the outer surface of the insertion extension portion (116) adjacent to the distal end (112b) of the insertion extension portion (116). A porous coating (122) is disposed on the outer surface of the insertion extension portion (116) adjacent to the proximal base (114). |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 18/252467 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2814 (20130101) Original (OR) Class A61F 2002/7887 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000726 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); The United States as Represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith T. Wilson (Nashville, Tennessee); John A. Oates (Nashville, Tennessee); Olivier Boutaud (Nashville, Tennessee); Venkataraman Amarnath (Nashville, Tennessee); Erica J. Carrier (Nashville, Tennessee); Alain P. Gobert (Nashville, Tennessee) |
| ABSTRACT | Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein. |
| FILED | Monday, July 10, 2023 |
| APPL NO | 18/220137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/135 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000891 | Goldberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Louis Goldberg (Menlo Park, California); Kun-Che Chang (Redwood City, California) |
| ABSTRACT | An effective dose of Growth Differentiation Factor 15 (GDF15) is used for prevention or treatment of proliferative vitreoretinopathy. Specifically, the disclosure provides methods and compositions for treatment of proliferative vitreoretinopathy (PVR), which is based on preventing or reducing proliferation, cell migration, or epithelial-mesenchymal transition (EMT) of epithelial cells involved in PVR. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 18/039187 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 38/1841 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002467 | Zimering |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark B. Zimering (Lyons, New Jersey) |
| ABSTRACT | Disclosed herein, are decoy peptides or polypeptides capable of inhibiting binding of 5-HT2A autoantibodies to a second extracellular loop region of the 5-HT2A receptor, and a pharmaceutical composition containing the decoy peptides or polypeptides and methods of use. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 18/038588 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/445 (20130101) A61K 31/506 (20130101) A61K 47/542 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/06 (20180101) A61P 9/12 (20180101) Peptides C07K 14/70571 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 2333/70571 (20130101) G01N 2333/91188 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002848 | Kraemer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES GOVERMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Kraemer (Kent, Washington); Jeanna M. Wheeler (Seattle, Washington); Pamela McMillan (Seattle, Washington); Timothy J. Strovas (Algona, Washington); Jeremy Baker (Seattle, Washington) |
| ABSTRACT | Disclosed herein are small interfering RNA (siRNA) molecules and their use in methods and pharmaceutical compositions for inhibiting the expression of mammalian suppressor of tauopathy 2. Also, described herein are the use of said siRNA molecules in the treatment of Alzheimer's disease or dementia, and reducing accumulation of phosphorylated and aggregated human tau. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 18/038307 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/55 (20130101) A61K 31/445 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240002871 | Simon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Silvec Biologics Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); Silvec Biologics Inc. (Gaithersburg, Maryland) |
| INVENTOR(S) | Anne Elizabeth Simon (Upper Marlboro, Maryland); Changyong Jang (Greenbelt, Maryland); Elizabeth Carino (Alexandria, Virginia); Feng Gao (College Park, Maryland) |
| ABSTRACT | The present disclosure relates to a viral vector suitable for introducing a therapeutic agent, such as a peptide, protein or small RNA, into a host or otherwise treating a host. The vector may include an exogenous RNA segment with a hairpin-like structure or having two or more base-paired regions separated by one or more non-base-paired regions. The exogenous RNA segment may have a secondary structure, minimum free energy, average positional entropy or other attributes within specified ranges, or with values similar to one or more hairpin-like structures of a reference wild type virus. Optionally, the RNA vector may be derived from the reference wild type virus or a relative of the reference wild type virus. In some examples, the vector is capable of capable of systemic and phloem-limited movement and replication within a host plant. In some examples, the reference wild type virus is an umbravirus-like associated RNA. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311495 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8249 (20130101) Original (OR) Class C12N 2796/00 (20220201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240002881 | Simon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Silvec Biologics Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); Silvec Biologics Inc. (Gaithersburg, Maryland) |
| INVENTOR(S) | Anne Elizabeth Simon (Upper Marlboro, Maryland); Changyong Jang (Greenbelt, Maryland); Elizabeth Carino (Alexandria, Virginia); Feng Gao (College Park, Maryland) |
| ABSTRACT | The present disclosure relates to a viral vector suitable for introducing a therapeutic agent, such as a peptide, protein or small RNA, into a host or otherwise treating a host. The vector may include an exogenous RNA segment with a hairpin-like structure or having two or more base-paired regions separated by one or more non-base-paired regions. The exogenous RNA segment may have a secondary structure, minimum free energy, average positional entropy or other attributes within specified ranges, or with values similar to one or more hairpin-like structures of a reference wild type virus. Optionally, the RNA vector may be derived from the reference wild type virus or a relative of the reference wild type virus. In some examples, the vector is capable of capable of systemic and phloem-limited movement and replication within a host plant. In some examples, the reference wild type virus is an umbravirus-like associated RNA. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311552 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240006581 | SHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sheldon Q. SHI (Dallas, Texas); Jiyao HU (Dallas, Texas); Xuan WANG (Dallas, Texas) |
| ABSTRACT | A method for forming a carbon electrode can include forming a blank comprising a bio-based material, constraining the blank, pyrolyzing the blank, and forming a carbon electrode based on pyrolyzing the blank. The method can also include activating the carbon electrode during the formation of the carbon electrode or thereafter. The bio-based material can include wood, coconut shell, bamboo, rice husks, hemp, jute, or any combination thereof. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345439 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0471 (20130101) Original (OR) Class H01M 4/583 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240000121 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Wednesday, September 13, 2023 |
| APPL NO | 18/367999 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1203 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/36 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) A23L 31/00 (20160801) Original (OR) Class A23L 33/195 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/208 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/00 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003376 | Rohrig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jake Rohrig (Simsbury, Connecticut); Laurance Robbins (Plainville, Connecticut) |
| ABSTRACT | A manifold having a borehole; and a repairable thread insert assembly, including: a shaft inserted in the borehole, the shaft defining: first and second end surfaces spaced apart from each other, wherein the shaft is shorter than the borehole; a threaded through hole extending between the end surfaces; and an outer surface extending between the end surfaces and defining an outer boundary shape that is complementary to the shape of the borehole; an elastic ring; an assembly fastener having a head that compresses the elastic ring between the head of the assembly fastener and the first end surface of the shaft such that the outer surface of the ring is pressed against the borehole, whereby the shaft is locked within the borehole. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946333 |
| CURRENT CPC | Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 37/127 (20130101) Original (OR) Class F16B 39/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240005196 | Marandi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Alireza Marandi (Pasadena, California); Rajveer Nehra (Pasadena, California); Ryoto Sekine (Pasadena, California); Luis M. Ledezma (La Crescenta, California) |
| ABSTRACT | A photonic integrated circuit comprising one or more waveguides comprising a second order non-linearity configured to operate on optical pulses each having a pulse length shorter than 1000 optical cycles, as measured at their full width at half maximum. The circuit is configured to generate one or more quantum states carried by one or more of the optical pulses, manipulate one or more of the quantum states, and/or measure one or more of the quantum states. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155444 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) G06N 10/70 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240000121 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Wednesday, September 13, 2023 |
| APPL NO | 18/367999 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1203 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/36 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) A23L 31/00 (20160801) Original (OR) Class A23L 33/195 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/208 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/00 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240000443 | Labriola et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Visionaire Products, Inc. (Sewickley, Pennsylvania) |
| ASSIGNEE(S) | Visionaire Products, Inc. (Sewickley, Pennsylvania) |
| INVENTOR(S) | Leanne Labriola (Sewickley, Pennsylvania); Rick W. Mental (Villa Park, Illinois); Deana McDonagh (Champaign, Illinois); Thomas Wei (Cary, North Carolina); Alex Gorsuch (Sewickley, Pennsylvania) |
| ABSTRACT | Provided herein are devices and methods for ocular fluid collection with minimal eye displacement, decreased risk of injury to structures in the eye and reduced ocular fluid sample loss. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 18/254915 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0283 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240004262 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, California); Government of the United States of America, as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Su-Peng Yu (Boulder, Colorado); Scott B. Papp (Boulder, Colorado); David Carlson (Boulder, Colorado); Kartik Srinivasan (Rockville, Maryland); Hojoong Jung (Seoul, South Korea) |
| ABSTRACT | A photonic device includes a substrate and a tantala ring resonator on the substrate. The tantala ring resonator has at least one of (i) a quality factor exceeding three million and (ii) a threshold power less than one hundred milliwatts. A frequency-comb generation method includes sweeping the output frequency of a laser coupled to a tantala ring resonator that has at least one of (i) a quality factor exceeding three million and (ii) a threshold power less than one hundred milliwatts. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/368886 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/34 (20130101) C23C 14/46 (20130101) C23C 14/083 (20130101) C23C 14/5806 (20130101) C23C 14/5826 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/355 (20130101) G02F 1/3513 (20130101) Original (OR) Class G02F 2203/17 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/2037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Smithsonian Institution (SI)
| US 20240002396 | Luesch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Smithsonian Institution (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Smithsonian Institution (Washington, District of Columbia) |
| INVENTOR(S) | Hendrik Luesch (Gainesville, Florida); Valerie J. Paul (Fort Pierce, Florida); Susan Matthew (Gainesville, Florida); Qi-Yin Chen (Gainesville, Florida); Ranjala Ratnayake (Gainesville, Florida) |
| ABSTRACT | The instant invention describes macrocyclic compounds having antiproliferation activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 18/030747 |
| CURRENT CPC | Heterocyclic Compounds C07D 498/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240005114 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | The present disclosure relates to a system for reading a barcode independently of image resolution or scale of a captured barcode image. In one embodiment, the system includes an optical sensor and a processor. The optical scanner can scan a barcode, including a plurality of bars and spaces, into a scanned image. The processor can convert the scanned image into binary data. The processor can also calculate numbers of ones (1s) between zeros (0s) in the binary data and determine widths of one of i) each of the bars and ii) each of the spaces based on the calculated numbers of ones (1s). The processor can further calculate numbers of zeros (0s) between ones (1s) in the binary data and determine widths of the other one of i) each of the bars and ii) each of the spaces based on the calculated numbers of zeros (0s). |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468158 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/10722 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240000823 | D'Andrea et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Alan D'Andrea (Winchester, Massachusetts); Kalindi Parmar (Arlington, Massachusetts); Haojian Zhang (Shrewsbury, Massachusetts) |
| ABSTRACT | The present invention provides methods of treating, preventing or delaying the onset of bone marrow failure in Fanconi Anemia patients |
| FILED | Thursday, July 20, 2023 |
| APPL NO | 18/224384 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Original (OR) Class A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) C12N 2310/10 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240001450 | Holcomb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Grid Logic Incorporated (Lapeer, Michigan) |
| ASSIGNEE(S) | Grid Logic Incorporated (Lapeer, Michigan) |
| INVENTOR(S) | Matthew J. Holcomb (Metamora, Michigan); Ira James Holcomb, Jr. (Shelby Twownship, Michigan) |
| ABSTRACT | The invention relates to a manufacturing system including a holder suitable to hold first particles of a first powder in proximity to one another, and a connection scheme which, when employed, connects the first particles to one another to form a part. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470382 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/12 (20210101) B22F 12/30 (20210101) B22F 12/52 (20210101) B22F 12/53 (20210101) Original (OR) Class B22F 12/222 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240003058 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Green (Phoenix, Arizona); Mani Modayil Korah (Tempe, Arizona) |
| ABSTRACT | Systems and methods for preparing encapsulant-containing polymer capsules and fibers, as well as the encapsulant-containing polymer capsules and fibers and composites including the same are described. In one example, forming a plurality of encapsulant-containing polymer capsules includes preparing a mixture comprising a polymer, a solvent, an encapsulant, and a polymer that is soluble in the solvent, and removing some of the solvent from the mixture to yield the plurality of polymer capsules. Each polymer capsule include a shell formed of the polymer and contains the encapsulant. In another example, forming a plurality of polymer fibers containing an encapsulant includes providing the mixture to an electrospin apparatus and electrospinning the mixture to yield the plurality polymer fibers, where each polymer fiber defines a hollow core that contains the encapsulant. |
| FILED | Thursday, January 20, 2022 |
| APPL NO | 18/039322 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/043 (20130101) B01J 13/125 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 1/02 (20130101) D01D 5/24 (20130101) D01D 5/0038 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, January 04, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240104.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page