FedInvent™ Patent Applications
Application Details for Thursday, January 25, 2024
This page was updated on Tuesday, June 18, 2024 at 02:12 PM GMT
Department of Health and Human Services (HHS)
| US 20240023528 | Akbari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar S. Akbari (La Jolla, California); Nikolay Kandul (La Jolla, California) |
| ABSTRACT | Provided is a gene editing system comprising (i) a polynucleotide encoding an endonuclease under the control of an inducible expressing regulatory sequence; (ii) a guide polynucleotide targeting a female-essential genomic sequence that is required for female-specific viability, and (iii) a guide polynucleotide targeting a male sterility genomic sequence that is required for male-specific fertility. Additionally provided are insect eggs, an insects, and an insect populations, each of which is genetically modified by the gene editing system. Further provided are methods and compositions relating to producing such systems, insect eggs, insects, insect populations and uses thereof in reducing a wild-type insect population. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/926970 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0339 (20130101) Original (OR) Class A01K 2227/706 (20130101) Peptides C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/635 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240023791 | Petrova et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas); William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Elena Petrova (Houston, Texas); Sharmila Anandasabapathy (Houston, Texas); Rebecca Richards-Kortum (Bellaire, Texas) |
| ABSTRACT | Systems and corresponding methods for an end-expandable optical fiber bundle are described herein. In one aspect, an endoscope can include a plurality of optical fibers each having a proximal end and a distal end; at least one camera coupled to the proximal ends of the plurality of optical fibers; and a sleeve enveloping the plurality of optical fibers proximate to the distal ends and repositionable along the length of the plurality of optical fibers, such that the sleeve is configured to control an angle of bend for each of the plurality of optical fibers as the optical fibers advance past the sleeve. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 18/041823 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/018 (20130101) A61B 1/043 (20130101) A61B 1/000096 (20220201) A61B 1/00167 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240023809 | DeBaun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Malcolm R. DeBaun (Menlo Park, California); Michael J. Gardner (Menlo Park, California) |
| ABSTRACT | Systems and methods for the detection of musculoskeletal anomalies are disclosed. Various embodiments are directed to methods to detect and treat anomalies, including fracture (e.g. clavicle), deformity (e.g. scoliosis), and other anomalies. Various embodiments utilize structured white light scanners, while additional embodiments utilize LiDAR to generate 3-dimensional (3D) topographic scans. Various embodiments obtain these scans via a mobile device, such as a mobile phone or tablet. Further embodiments utilize machine learning models to analyze the 3D scans to identify an anomaly and/or a treatment for such anomaly and/or monitor change of that condition over time. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/759919 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0013 (20130101) A61B 5/0046 (20130101) A61B 5/0064 (20130101) Original (OR) Class A61B 5/1071 (20130101) A61B 5/4561 (20130101) A61B 5/4576 (20130101) A61B 5/4848 (20130101) A61B 2560/0431 (20130101) A61B 2576/02 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/89 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240023859 | Klin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ami Klin (Atlanta, Georgia); Warren Jones (Decatur, Georgia); Sarah Shultz (Atlanta, Georgia) |
| ABSTRACT | The present systems and methods provide a mechanism to assess viewer behavior, features of stimuli, and the interaction between viewer behavior and stimuli. The systems and methods described herein for quantifying blink response and blink inhibition provide moment-by-moments measurements of viewer engagement by measuring what is or is not engaging enough to warrant viewers' inhibition of blinking. The present disclosure describes measures of visual scanning, eye movements, blink data, and blink timing data to derive a measure of how engaged a person is with what he or she is looking at. Blink-related data as a measure of viewer engagement provides a mechanism for determining the most engaging spatial and temporal aspects of a stimulus. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363323 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/0041 (20130101) A61B 3/112 (20130101) A61B 3/113 (20130101) A61B 5/163 (20170801) A61B 5/165 (20130101) Original (OR) Class A61B 5/167 (20130101) A61B 5/168 (20130101) A61B 5/1103 (20130101) A61B 5/4088 (20130101) A61B 5/7275 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240023888 | NARAYAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Sanjiv M. NARAYAN (Palo Alto, California); Mahmood ALHUSSEINI (Palo Alto, California) |
| ABSTRACT | A system and method for identifying and treating a disease in a patient collects one or more data streams from sensors configured to detect biological signals generated within a patient's tissue over time. Patient data elements including one or more of demographic, clinical, laboratory, pathology, chemical, image, historical, genetic, and activity data for the patient is collected and processed with the data streams to generate a personalized digital phenotype (PDP). The PDP is compared to a digital taxonomy comprising prior data to classify the patient into one or more quantitative disease classifications to guide personalized intervention for treating the patient. |
| FILED | Thursday, August 17, 2023 |
| APPL NO | 18/235177 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/024 (20130101) A61B 5/361 (20210101) A61B 5/363 (20210101) A61B 5/0816 (20130101) A61B 5/4836 (20130101) Original (OR) Class A61B 5/7246 (20130101) A61B 5/7264 (20130101) A61B 2562/0204 (20130101) A61B 2562/0219 (20130101) A61B 2562/0238 (20130101) A61B 2562/0271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024031 | TRAYANOVA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natalia A. TRAYANOVA (Baltimore, Maryland); Kathleen MCDOWELL (Baltimore, Maryland) |
| ABSTRACT | Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (AF) patient with atrial fibrosis are disclosed. Three-dimensional imaging data representing the atria of the patient may be received. A patient-specific model of the atria may be generated from the three-dimensional imaging data. Simulation of the AF on the patient-specific model may be conducted to identify AF-perpetrating regions. One or more ablation locations in the atria may be identified from the AF-perpetrating regions. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/480049 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) Original (OR) Class A61B 2018/00351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024089 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Longhai WANG (Ithaca, New York); Alexander ERNST (Ithaca, New York); Minglin MA (Ithaca, New York); James FLANDERS (Ithaca, New York) |
| ABSTRACT | The present disclosure is directed to devices and systems for oxygenating encapsulated cells. The disclosure further relates to individual components of these devices and systems and methods of using the devices and systems to deliver a therapeutic agent to a subject in need thereof. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 18/256441 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/022 (20130101) Original (OR) Class A61F 2002/0081 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/18 (20130101) A61L 27/025 (20130101) A61L 27/38 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024237 | McPherson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David D. McPherson (Houston, Texas); Shao-Ling Huang (Sugarland, Texas); Melvin Klegerman (Houston, Texas); Susan T. Laing (Houstin, Texas); Patrick Kee (Houston, Texas); Tao Peng (Houston, Texas); Hyunggun Kim (Hwasung, South Korea); Melanie Moody (Sugarland, Texas) |
| ABSTRACT | Disclosed are compositions comprising a first liposome, comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and at least one vasodilator; and a second liposome, comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, at least one thiazolidinedione, and at least one compound having an affinity for at least one component of an atheroma. Also disclosed are methods for forming the compositions and methods of using the compositions to ameliorate atheroma. |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/351017 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 9/127 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 33/00 (20130101) A61K 47/06 (20130101) A61K 47/543 (20170801) A61K 47/6849 (20170801) A61K 47/6913 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024250 | Traverso et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Carlo Giovanni Traverso (Newton, Massachusetts); Alex G. Abramson (St. Louis, Missouri); Ester Caffarel Salvador (Somerville, Massachusetts); Niclas Roxhed (Bromma, Sweden); Minsoo Khang (Boston, Massachusetts); Taylor Bensel (Walpole, Massachusetts); Robert S. Langer (Newton, Massachusetts) |
| ABSTRACT | Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression). |
| FILED | Thursday, June 01, 2023 |
| APPL NO | 18/204882 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14503 (20130101) A61B 5/14539 (20130101) A61B 10/02 (20130101) A61B 10/0233 (20130101) A61B 2010/0208 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 3/07 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0002 (20130101) A61K 9/0012 (20130101) A61K 9/0021 (20130101) A61K 9/0065 (20130101) A61K 9/0092 (20130101) A61K 9/4808 (20130101) Original (OR) Class A61K 9/4866 (20130101) A61K 38/28 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/158 (20130101) A61M 5/329 (20130101) A61M 5/1454 (20130101) A61M 5/2033 (20130101) A61M 5/3295 (20130101) A61M 5/14276 (20130101) A61M 31/002 (20130101) A61M 37/0015 (20130101) A61M 37/0069 (20130101) A61M 2005/1585 (20130101) A61M 2005/14284 (20130101) A61M 2037/0023 (20130101) A61M 2037/0053 (20130101) A61M 2205/21 (20130101) A61M 2205/0238 (20130101) A61M 2210/106 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/325 (20130101) A61N 1/0509 (20130101) A61N 1/36007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024283 | Atwood et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Walter J. Atwood (Rumford, Rhode Island); Jacob S. Kaiserman (Garden City, New York) |
| ABSTRACT | Described are compositions and methods for treating polyoma viruses such as JCPyV. |
| FILED | Thursday, July 20, 2023 |
| APPL NO | 18/224304 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024286 | VIDYASAGAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sadasivan VIDYASAGAR (Gainesville, Florida); Paul OKUNIEFF (Gainesville, Florida); Lurong ZHANG (Gainesville, Florida) |
| ABSTRACT | The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363448 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0095 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/405 (20130101) Original (OR) Class A61K 31/7004 (20130101) A61K 31/7016 (20130101) A61K 47/20 (20130101) A61K 47/183 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024302 | SAFFITZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (Boston, Massachusetts); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey E. SAFFITZ (Waban, Massachusetts); Bruce D. HAMMOCK (Davis, California); Sung Hee HWANG (Woodland, California) |
| ABSTRACT | Provided herein are methods of preventing, mitigating, decreasing, reversing and/or treating Arrhythmogenic Cardiomyopathy (ACM) in a subject in need thereof, comprising administering to the subject an effective amount of a compound of Formula I, a compounds of Formula II, or a compound of Formula III (I) (II), (III) wherein R1, R2, R3, n, R4, R4a, R5, m, R6, R7, and p are as defined herein. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 18/250504 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) A61K 31/4515 (20130101) Original (OR) Class A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024304 | Ressler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| INVENTOR(S) | Kerry J. Ressler (Atlanta, Georgia); Raul Andero Gali (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to managing conditioned fear and conditions induced by experiencing or witnessing an extreme traumatic event using neurokinin receptor antagonists. In certain embodiments, the disclosure relates to methods of treating or preventing conditioned fear comprising administering an effective about neurokinin 3 receptor antagonist to a subject in need thereof. In certain embodiments, the subject is diagnosed with Post-Traumatic Stress Disorder. |
| FILED | Friday, April 28, 2023 |
| APPL NO | 18/140914 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4545 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024325 | Huggett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); Clemson University Research Foundation (Clemson, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Spencer B. Huggett (Atlanta, Georgia); Rohan H. C. Palmer (Atlanta, Georgia); Robert Anholt (Greenwood, South Carolina); Trudy MacKay (Greenwood, South Carolina) |
| ABSTRACT | This disclosure relates to using compounds disclosed herein to treat or prevent cocaine use disorder, cocaine toxicity, or other drug related disorders. In certain embodiments, this disclosure relates to methods of treating drug addiction or to help prevent relapse. In certain embodiments, this disclosure relates to methods of treating or preventing cocaine use disorder, cocaine toxicity, or other use disorders comprising administering an effective amount of a compound disclosed herein, such as ibrutinib, [(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one], derivative, or salt thereof to a subject in need thereof. In certain embodiments, the compound is a Bruton's tyrosine kinase (BTK) inhibitor. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 18/023797 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/5513 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024359 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Seattle Children's Hospital DBA Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yvonne Y. Chen (Los Angeles, California); Eugenia Zah (Los Angeles, California); Michael C. Jensen (Seattle, Washington) |
| ABSTRACT | A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR. |
| FILED | Friday, August 25, 2023 |
| APPL NO | 18/238210 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70596 (20130101) C07K 16/46 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024362 | Lowsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Lowsky (Stanford, California); Samuel Strober (Portola Valley, California); Everett Hurteau Meyer (Belmont, California); Kent Jensen (Redwood City, California); Stephan Busque (Stanford, California) |
| ABSTRACT | Compositions and methods are provided for the achievement of organ and tissue transplantation and autoimmune tolerance using the infusion of living and/or deceased donor hematopoietic cells. The methods provided herein provide for conditioning with a plurality of doses of total lymphoid irradiation (TLI), and a single, very low dose of TBI (svldTBI), referred to herein as “TLI-svldTBI-ATG” or “TLI-svldTBI” depending on whether ATG is included. The combination of svldTBI and TLI specifically targets non-lymphoid-tissue resident memory immune cells. An in vitro manipulated donor cell composition is provided for use with the conditioning regimen, in which specific ratios of CD34+ and other hematopoietic stem cell and precursor cell populations are combined with defined doses of CD3+ T cells, and/or purified regulatory T cells (Treg) cells, invariant natural killer (iNK-T) cells, and/or CD8+ memory T cells. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 18/028050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 2035/124 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024368 | HE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Zhigang HE (Boston, Massachusetts); Shane HEGARTY (Boston, Massachusetts); Feng TIAN (Boston, Massachusetts); Joanna STANICKA (Boston, Massachusetts); Songlin ZHOU (Boston, Massachusetts) |
| ABSTRACT | As described below, the present invention features compositions and methods for neuroprotection and/or neuroregeneration of damaged or degenerating neurons. In various embodiments, the compositions and methods of the present disclosure are used to treat a neurodegenerative disease and/or nervous system injury. The methods in various embodiments include reducing or eliminating activity or expression of a target gene(s) and/or a polypeptide(s) expressed by a target gene(s) in a neuron. |
| FILED | Friday, July 14, 2023 |
| APPL NO | 18/352730 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024372 | Morris et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin V. Morris (Duarte, California); Olga Raquel Villamizar Beltran (Duarte, California) |
| ABSTRACT | The disclosure provides, inter alia, fusion proteins comprising a zinc finger domain and a transcriptional activator, nucleic acids, vectors, and exosomes that can be used to activate transcription in a cystic fibrosis transmembrane conductance regulator gene and treat cystic fibrosis. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 18/265544 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/42 (20130101) Original (OR) Class Peptides C07K 14/4712 (20130101) C07K 2319/09 (20130101) C07K 2319/71 (20130101) C07K 2319/81 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024380 | Fischbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHAN ZUCKERBERG BIOHUB, INC. (San Franicisco, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. Fischbach (Stanford, California); Kazuki Nagashima (Palo Alto, California); Yiyin E. Chen (Stanford, California); Djenet Bousbaine (Mountain View, California) |
| ABSTRACT | Provided are modified microorganisms, such as live recombinant commensal bacteria, that express a non-native antigen, or are surface-labeled with a non-native antigen, and methods of using the modified microorganisms to induce an antigen-specific immune response to the non-native antigen. The modified microorganism can be used to induce a regulatory T cell immune response to the heterologous antigen to treat an autoimmune disease in a subject in need thereof, or can be used to induce an effector T cell immune response to the heterologous antigen to treat an infectious disease or proliferative disease in a subject in need thereof. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 18/269237 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/2833 (20130101) C07K 16/2845 (20130101) C07K 2319/02 (20130101) C07K 2319/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024381 | Kenny et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Kenny (Cambridge, Massachusetts); Hera Vlamakis (Cambridge, Massachusetts); Ramnik Xavier (Cambridge, Massachusetts); Emily Balskus (Cambridge, Massachusetts); Damian Plichta (Cambridge, Massachusetts) |
| ABSTRACT | Microbes expressing cholesterol oxidoreductase (COR) proteins, methods of engineering the microbes expressing COR proteins, compositions and methods of using the microbes are provided. |
| FILED | Monday, March 06, 2023 |
| APPL NO | 18/178966 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/575 (20130101) A61K 35/741 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 15/70 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/10 (20130101) C12Q 1/26 (20130101) Enzymes C12Y 101/03006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/902 (20130101) G01N 2800/044 (20130101) G01N 2800/50 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024387 | STEINBACH-RANKINS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jill M. STEINBACH-RANKINS (Crestwood, Kentucky); Donald R. DEMUTH (Louisville, Kentucky) |
| ABSTRACT | A probiotic delivery system is provided, as are methods of making and using such a probiotic delivery system. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 18/248491 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/205 (20130101) A61K 9/2095 (20130101) A61K 35/745 (20130101) A61K 35/747 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/23 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024394 | Irvine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Darrell J. Irvine (Arlington, Massachusetts); Karl Dane Wittrup (Chestnut Hill, Massachusetts); Ron Weiss (Newton, Massachusetts); Yingzhong Li (Quincy, Massachusetts); Noor Momin (Cambridge, Massachusetts); Yizhou Dong (Dubin, Ohio) |
| ABSTRACT | The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule. |
| FILED | Wednesday, June 14, 2023 |
| APPL NO | 18/334449 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/768 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/5434 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/36132 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024410 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun O. Liu (Baltimore, Maryland); Zhiqiang Cheng (Baltimore, Maryland); Heng Zhu (Baltimore, Maryland); Zufeng Guo (Baltimore, Maryland); Hanjing Peng (Baltimore, Maryland) |
| ABSTRACT | Surface structures that enable the preparation of three-dimensional microarrays of proteins or small molecules or other types of macromolecules are disclosed. The three-dimensional microarrays possess higher sensitivity for detecting protein-macromolecule and small molecule-protein interactions in a high-throughput fashion. |
| FILED | Wednesday, October 07, 2020 |
| APPL NO | 17/766570 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) G01N 33/6872 (20130101) G01N 33/54386 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024411 | PAVLIV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cumberland Pharmaceuticals Inc. (Nashville, Tennessee) |
| ASSIGNEE(S) | Cumberland Pharmaceuticals Inc. (Nashville, Tennessee) |
| INVENTOR(S) | Leo PAVLIV (Cary, North Carolina); Ines MACIAS-PEREZ (Mt. Juliet, Tennessee) |
| ABSTRACT | Methods for preventing or treating a Bacillus anthracis (anthrax) infection in a subject, such as a mammal, by administering to the subject telavancin or a pharmaceutically-acceptable salt thereof. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992470 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/14 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024430 | Sen Gupta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anirban Sen Gupta (Cleveland, Ohio); Christa Pawloski (Seven Hills, Ohio) |
| ABSTRACT | A synthetic platelet including a biocompatible flexible nanoparticle, the nanoparticle having an outer surface and a plurality of site targeted peptides conjugated to the surface, the synthetic platelet also including a therapeutic agent, wherein the therapeutic agent is encapsulated by the nanoparticle, wherein the synthetic platelet adheres to the site targeted and promotes delivery of the therapeutic agent onto sites of the synthetic platelet adhesion, and wherein the therapeutic agent is released at the site targeted via a site-relevant enzyme. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/943955 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/19 (20130101) A61K 9/127 (20130101) A61K 9/1271 (20130101) A61K 9/4825 (20130101) A61K 38/00 (20130101) A61K 38/39 (20130101) Original (OR) Class A61K 38/177 (20130101) A61K 38/185 (20130101) A61K 38/1774 (20130101) A61K 47/62 (20170801) A61K 47/6911 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 14/78 (20130101) C07K 14/195 (20130101) C07K 14/745 (20130101) C07K 14/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024435 | Avci et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fikri Y. Avci (Watkinsville, Georgia); Dustin Middleton (Athens, Georgia); Amy Victoria Paschall (Washington, Georgia) |
| ABSTRACT | Provided herein is a protein, referred to as a Pn3Pase protein, that degrades the capsular polysaccharide of serotype 3 Streptococcus pneumoniae. The disclosure includes a genetically modified cell that includes a Pn3Pase protein, and compositions that include the protein, the polynucleotide encoding the protein, the genetically modified cell, or a combination thereof. Also provided are methods for using a Pn3Pase protein, including methods for contacting a S. pneumoniae having a type III capsular polysaccharide with a Pn3Pase protein, increasing deposition of at least one complement component on the surface of a S. pneumoniae, treating an infection in a subject, treating a symptom in a subject, decreasing colonization of a subject by S. pneumoniae, or a combination thereof. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/199685 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/2402 (20130101) C12N 2510/00 (20130101) Enzymes C12Y 302/01031 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024436 | CHAE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Yun-Cheol CHAE (Chestnut Hill, Massachusetts); Alejandro GUTIERREZ (Brookline, Massachusetts) |
| ABSTRACT | Described herein are methods and compositions for treating cancer. Aspects of the invention relate to administering to a subject having cancer an asparaginase and an agent that inhibits G6PD. Another aspect of the invention relates to administering an asparaginase to a subject having cancer that comprises a G6PD deficiency. |
| FILED | Wednesday, June 07, 2023 |
| APPL NO | 18/206830 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/50 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) Enzymes C12Y 305/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024450 | Beernink et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S HOSPITAL and RESEARCH CENTER AT OAKLAND (Oakland, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter T. Beernink (Walnut Creek, California); Dhaarini Raghunathan (Oakland, California) |
| ABSTRACT | Variant Neisserial surface protein A (NspA) with reduced binding to human factor H (FH) are provided. These variants are useful for eliciting antibodies that are bactericidal for at least one strain of N. meningitidis. Compositions comprising such proteins, and methods of use of such proteins are disclosed. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 18/040134 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/095 (20130101) Original (OR) Class A61K 2039/55505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024452 | Steinmetz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Amy M. Wen (Cleveland, Ohio); Steven Fiering (Hanover, New Hampshire); Patrick H. Lizotte (Hanover, New Hampshire) |
| ABSTRACT | A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle. |
| FILED | Tuesday, August 22, 2023 |
| APPL NO | 18/236676 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024454 | LIVENGOOD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TAKLEDA VACCINES, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jill A. LIVENGOOD (Cambridge, Massachusetts); Holli Giebler (Cambridge, Massachusetts); Hansi Dean (Cambridge, Massachusetts); Tatsuki Satou (Hikari-Shi, Japan); Raman Rao (Singapore, Singapore); Jackie Marks (Cambridge, Massachusetts); Mark Lyons (Cambridge, Massachusetts); Asae Shintani (Hikari-shi, Japan); James Gifford (Cambridge, Massachusetts); Nao Ogasawara (Osaka, Japan); Masafumi Misaki (Hikari-shi, Japan); Satoshi Adachi (Hikari-shi, Japan); Sushma Kommareddy (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation and to a method for determining the residual formaldehyde content in a pharmaceutical composition comprising an inactivated virus. |
| FILED | Thursday, June 22, 2023 |
| APPL NO | 18/339553 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024458 | Kwong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Institute For Research in Biomedicine (Bellinzona, Switzerland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Institute For Research in Biomedicine (Bellinzona, Switzerland) |
| INVENTOR(S) | Peter Kwong (Washington, District of Columbia); Michael Gordon Joyce (Washington, District of Columbia); Baoshan Zhang (Bethesda, Maryland); Yongping Yang (Potomac, Maryland); Peter Collins (Kensington, Maryland); Ursula Buchholz (Silver Spring, Maryland); Davide Corti (Bellinzona, Switzerland); Antonio Lanzavecchia (Bellinzona, Switzerland); Guillaume Stewart-Jones (Cambridge, Massachusetts) |
| ABSTRACT | Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection. |
| FILED | Wednesday, September 06, 2023 |
| APPL NO | 18/462340 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/155 (20130101) Original (OR) Class A61K 48/00 (20130101) Peptides C07K 14/005 (20130101) C07K 14/135 (20130101) C07K 2319/70 (20130101) C07K 2319/73 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18322 (20130101) C12N 2760/18334 (20130101) C12N 2760/18522 (20130101) C12N 2760/18534 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024463 | FRIEDMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Harvey FRIEDMAN (Merion, Pennsylvania); Drew WEISSMAN (Wynnewood, Pennsylvania); Sita AWASTHI (Bala Cynwyd, Pennsylvania); Gary Cohen (Havertown, Pennsylvania) |
| ABSTRACT | The present invention provides compositions for the prevention and treatment of genital herpes, comprising nucleoside modified mRNAs that encode herpes simplex virus (HSV) glycoproteins, including those involved in virus entry and immune evasion, and methods of use thereof. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470325 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0036 (20130101) A61K 39/245 (20130101) Original (OR) Class A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024466 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiaobing Xu (Medford, Massachusetts); Jinjin chen (Medford, Massachusetts) |
| ABSTRACT | Disclosed are lipidoid compositions that are capable of treating or preventing certain diseases (e.g., cancer or viral infections). Also disclosed are pharmaceutical compositions, comprising the lipidoid compositions. The present disclose also relates to methods of using the lipidoid compositions, and related kits comprising the lipidoid compositions. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 18/265561 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 39/215 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024469 | Bazin-Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF MONTANA (Missoula, Montana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Helene Bazin-Lee (Stevensville, Montana); David Burkhart (Missoula, Montana); Jay Evans (Corvallis, Montana) |
| ABSTRACT | Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmune disorders. |
| FILED | Tuesday, August 08, 2023 |
| APPL NO | 18/446041 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 2039/55505 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65616 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024474 | Avigan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David Avigan (Sharon, Massachusetts); Jacalyn Rosenblatt (Newton, Massachusetts); Donald Kufe (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Beth Istael Deaconess Medical Center (Bosto, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Avigan (Sharon, Massachusetts); Jacalyn Rosenblatt (Newton, Massachusetts); Donald Kufe (Wellesley, Massachusetts) |
| ABSTRACT | The present invention provides compositions and methods for treating cancer. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 18/031260 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/191 (20130101) A61K 38/1709 (20130101) A61K 39/3955 (20130101) A61K 39/4611 (20230501) Original (OR) Class A61K 39/4631 (20230501) A61K 39/464412 (20230501) A61K 39/464417 (20230501) A61K 47/36 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/16 (20130101) C12N 5/0636 (20130101) C12N 2501/998 (20130101) C12N 2502/99 (20130101) C12N 2533/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024479 | Childs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Richard W. Childs (Rockville, Maryland); David S.J. Allan (Rockville, Maryland) |
| ABSTRACT | Modified natural killer (NK) or T cells expressing hematopoietic growth factor receptors are provided. In some aspects, the modified NK cells or T cells express a thrombopoietin receptor, an erythropoietin receptor, or a chimeric polypeptide including an extracellular domain of a thrombopoietin receptor, a transmembrane domain, and an intracellular domain including an interleukin-2 receptor beta intracellular signaling domain. Methods of treating a subject with cancer are also provided, including administering the modified NK cells or T cells to the subject in combination with a thrombopoietin receptor agonist or erythropoietin receptor agonist, and in some example, interleukin-2, particularly reduced or low-dose amounts of IL-2. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/480306 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4152 (20130101) A61K 38/196 (20130101) A61K 38/2013 (20130101) A61K 39/4611 (20230501) A61K 39/4613 (20230501) A61K 39/4637 (20230501) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/715 (20130101) C07K 14/7056 (20130101) C07K 14/7155 (20130101) C07K 14/7156 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70535 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024487 | Varghese et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shyni Varghese (Durham, North Carolina); Anna Gilpin (Durham, North Carolina); Jiaul Hoque (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are self-repairing biomimetic lubricant compounds, compositions comprising the same, and methods of making and using the same. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 18/251950 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/735 (20130101) A61K 45/06 (20130101) A61K 47/545 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/08 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024490 | Choudhary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Choudhary (Boston, Massachusetts); Veronika Shoba (Cambridge, Massachusetts); Arghya Deb (Cambridge, Massachusetts); Tuan Nguyen (Boston, Massachusetts); Sophia Lai (Boston, Massachusetts); Dhanushka Munkanatta Godage (Cambridge, Massachusetts); Praveen Tiwari (Boston, Massachusetts); Ashley Modell (Cambridge, Massachusetts); Sachini Siriwardena (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to bifunctional chemical conjugation molecules, which find utility as modifiers of target substrates. The present disclosure includes multifunctional compounds comprising an enzyme binding moiety, a chemical linker moiety, and a target binding moiety, which may further include an electrophilic reactive group. Molecules according to the present invention find use making substrate modifications such as post-translational modifications to proteins that are not the natural substrate of the enzyme. Diseases or disorders may be treated or prevented with molecules of the present disclosure. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/999364 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class A61K 47/545 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 1/1077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024495 | Brown et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Kathlynn C. Brown (Staunton, Virginia); Curtis Allred (Menlo Park, California); Michael McGuire (Harrisonburg, Virginia) |
| ABSTRACT | Disclosed herein, are compositions comprising one or more a molecular guidance system (MGS) peptides and a cytotoxic agent. Also described herein, are methods of administering the compositions to patients with cancer. |
| FILED | Friday, July 14, 2023 |
| APPL NO | 18/352791 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/168 (20130101) A61K 45/06 (20130101) A61K 47/60 (20170801) A61K 47/6415 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024503 | Bam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rakesh Bam (Menlo Park, California); Jeremy Dahl (Palo Alto, California) |
| ABSTRACT | Methods and compositions for the production of phospholipid-ligand bioconjugates and uniform targeted microbubbles are provided. These methods and compositions find use in ultrasound and molecular imaging applications related to cancer and other diseases. The methods of the present disclosure comprise contacting a phospholipid comprising a maleimide containing functional group with a ligand comprising a C terminal cysteine residue. The methods disclosed herein solves the problems in producing ready-to-use and clinically translatable ultrasound molecular imaging agents by incorporating small protein ligands engineered to bind against biomarkers representing pathological angiogenesis or abnormal cells. The methods also overcome the current limitations in producing uniformly targeted microbubbles in a scalable, economical and reproducible manner. |
| FILED | Thursday, July 13, 2023 |
| APPL NO | 18/352081 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/6909 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024505 | Grinstaff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Mark W. Grinstaff (Brookline, Massachusetts); Jack R. Kirsch (Cambridge, Massachusetts); Amanda K. Williamson (Boston, Massachusetts); Brett Tingley (Brighton, Massachusetts) |
| ABSTRACT | The disclosure relates generally to methods and compositions for generation or enhancement of partial or complete cellular signaling pathways |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/221206 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1617 (20130101) A61K 38/28 (20130101) A61K 38/2221 (20130101) A61K 48/0033 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024509 | LEHTINEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Maria K. LEHTINEN (Boston, Massachusetts); Ryann M. FAME (Boston, Massachusetts); Cameron SADEGH (Boston, Massachusetts); Huixin XU (Boston, Massachusetts) |
| ABSTRACT | Provided are methods and compositions for treating cerebrospinal fluid disorders. In embodiments, the methods comprise administering an agent to a subject altering activity, expression, or level of NKCC1 in a cell. |
| FILED | Thursday, July 27, 2023 |
| APPL NO | 18/360505 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0075 (20130101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024510 | Hinderer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Christian Hinderer (Baltimore, Maryland); James M. Wilson (Philadelphia, Pennsylvania) |
| ABSTRACT | A suspension useful for AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDUA gene is provided herein. Also provided are methods and kits containing these vectors and compositions useful for treating MPSI and the symptoms associated with Hurler, Hurler-Scheie and Scheie syndromes. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/475999 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) C12N 15/86 (20130101) C12N 15/8645 (20130101) C12N 2750/14143 (20130101) C12N 2830/15 (20130101) Enzymes C12Y 302/01076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024615 | Zhao |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Zhao (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are devices, including nasal plugs and nasal clips, for modulating olfaction, as well as methods of using thereof to increase or decrease olfactory sensitivity. |
| FILED | Friday, April 07, 2023 |
| APPL NO | 18/297495 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 21/00 (20130101) Original (OR) Class A61M 2021/0016 (20130101) A61M 2209/088 (20130101) A61M 2210/0618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024616 | EFIRD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MATTHEW EFIRD (COLUMBIA, South Carolina); CONRAD M. GORE (COLUMBIA, South Carolina); ANA POCIVAVSEK (COLUMBIA, South Carolina); HOMAYOUN VALAFAR (ELGIN, South Carolina) |
| ABSTRACT | The disclosure deals with a system and method for inducing sleep loss in animal test subjects, such as rats. A sleep deprivation chamber uses a DC Servo motor with a controller to cause a bar to sweep across the rodent cage floor. The system is programmed to sweep the bar across the floor of the rodent cage at varying intervals. The maximum speed at which the bar sweeps the entire rodent cage is within 3 seconds. The chamber is designed such that it can structurally accommodate a receiver and record EEG/EMG telemetrically in animals that have been implanted with sleep transmitters. During the sleep deprivation protocol, food and water are available to animals in the chamber at all times. The chamber is also designed to fit a standardized rodent (e.g., rat or mouse) cage, and plural cages such as an 8-chamber sleep restriction device can be simultaneously operated. |
| FILED | Monday, July 17, 2023 |
| APPL NO | 18/353326 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 21/0094 (20130101) Original (OR) Class A61M 2021/0083 (20130101) A61M 2250/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024705 | XU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen XU (Ann Arbor, Michigan); Clifford Suhyun CHO (Ann Arbor, Michigan) |
| ABSTRACT | Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/478342 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0045 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025868 | Mobbs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles Mobbs (New York, New York); Jian Jin (New York, New York); Christopher Kellner (New York, New York); H. Umit Kaniskan (New York, New York); Tao Cao (New York, New York); Jianping Hu (New York, New York); James Vicari (New York, New York); Bik Tzu Huang (New York, New York); Yonejung Yoon (New York, New York); Rachel Litke (New York, New York) |
| ABSTRACT | Disclosed are phenothiazine compounds which reduce Abeta toxicity in vivo, reduce microglial inflammation as indicated by secretion of TNF-alpha, reduce intracerebral hemorrhage in vivo toxicity as indicated by preserved motor and cognitive function, and SARS-CoV-2 replication. Also disclosed are methods of use thereof for the treatment of disease in a subject in need thereof. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 18/036095 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 31/14 (20180101) Heterocyclic Compounds C07D 279/20 (20130101) C07D 279/22 (20130101) C07D 279/28 (20130101) C07D 279/30 (20130101) Original (OR) Class C07D 417/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025892 | Wein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc Nathan Wein (Wellesley, Massachusetts); William J. Greenlee (Teaneck, New Jersey) |
| ABSTRACT | The present application provides compounds that modulate the activity of one or more salt inducible kinases (SIKs). Pharmaceutical composition and methods of treating diseases associated with abnormal expression and/or activity of one or more SIKs are also provided. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 18/019527 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/12 (20130101) C07D 403/04 (20130101) C07D 403/12 (20130101) C07D 405/14 (20130101) C07D 409/14 (20130101) C07D 471/04 (20130101) Original (OR) Class C07D 471/10 (20130101) C07D 487/10 (20130101) C07D 498/10 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025929 | Singer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HelixBind, Inc. (Boxborough, Massachusetts) |
| ASSIGNEE(S) | HelixBind, Inc. (Boxborough, Massachusetts) |
| INVENTOR(S) | Alon Singer (Concord, Massachusetts); David Steinmiller (Half Moon Bay, California); Nadish Goyal (Marlborough, Massachusetts); Jork Nolling (Hopedale, Massachusetts) |
| ABSTRACT | The present disclosure generally relates to the field of ultrasensitive microbial pathogen detection and identification utilizing genomic sequence recognition. |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/351061 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/1411 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) C12Q 1/6888 (20130101) C12Q 2523/10 (20130101) C12Q 2527/119 (20130101) C12Q 2527/137 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025945 | BOGYO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California) |
| INVENTOR(S) | Matthew S. BOGYO (Redwood City, California); Martijn VERDOES (Nijmegen, Netherlands); Leslie OFORI (Jupiter, Florida); Nimali P. WITHANA (Menlo Park, California) |
| ABSTRACT | Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 18/053682 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0056 (20130101) A61K 51/08 (20130101) A61K 51/088 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/08 (20130101) C07D 405/06 (20130101) Peptides C07K 5/06086 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025951 | Beernink |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children’s Hospital and Research Center at Oakland (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter T. Beernink (Walnut Creek, California) |
| ABSTRACT | Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising such proteins, and methods of use of such proteins, are provided. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/316594 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/095 (20130101) A61K 2039/55505 (20130101) Peptides C07K 14/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025952 | Malley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Richard Malley (Beverly, Massachusetts); Yingjie Lu (West Roxbury, Massachusetts); Fan Zhang (West Roxbury, Massachusetts) |
| ABSTRACT | The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046485 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/092 (20130101) A61K 39/385 (20130101) A61K 47/61 (20170801) A61K 47/543 (20170801) A61K 47/557 (20170801) A61K 2039/6031 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/31 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240025966 — CD47 BLOCKADE AND COMBINATION THERAPIES THEREOF FOR REDUCTION OF VASCULAR INFLAMMATION
| US 20240025966 | Leeper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas J. Leeper (Stanford, California); Irving L. Weissman (Stanford, California); Kai-Uwe Jarr (Redwood City, California); Yoko Kojima (Redwood City, California) |
| ABSTRACT | Methods are provided for the prevention and treatment of vascular inflammation. The methods comprise administering to a human subject an effective dose of an agent that specifically binds to CD47, and reduces one or more indicia of vascular inflammation. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 18/031840 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 14/70596 (20130101) Original (OR) Class C07K 2319/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025982 | Dietz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harry C. Dietz (Townson, Maryland); Jefferson J. Doyle (Baltimore, Maryland); Alexander J. Doyle (Baltimore, Maryland) |
| ABSTRACT | The instant disclosure provides methods and compositions for the diagnosis, treatment and prevention of Marfan syndrome and related diseases, disorders and conditions. The disclosure further provides pharmaceutical compositions and kits for the diagnosis, treatment and prevention of Marfan syndrome and related diseases, disorders and conditions. |
| FILED | Thursday, May 25, 2023 |
| APPL NO | 18/202066 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Heterocyclic Compounds C07D 239/94 (20130101) Peptides C07K 16/22 (20130101) Original (OR) Class C07K 16/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025986 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong Feng Chen (Newtonville, Massachusetts); Ji Min (Boston, Massachusetts); Kin-Sang Cho (Boston, Massachusetts) |
| ABSTRACT | The invention provides compositions and methods for treating optic neuropathic disorders. |
| FILED | Tuesday, May 16, 2023 |
| APPL NO | 18/318336 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/193 (20130101) A61K 45/06 (20130101) Peptides C07K 16/243 (20130101) Original (OR) Class C07K 16/2866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025990 | ZENG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Defu ZENG (Duarte, California); Arthur D. RIGGS (Duarte, California); Qingxiao SONG (Duarte, California) |
| ABSTRACT | Disclosed is a method of preventing or treating GVHD while preserving GVL activity in a subject receiving a hematopoietic cell transplantation (HCT) by administering to the subject an effective amount of an anti-IL-2 antibody such as an anti-IL-2-JES6 antibody. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 18/255503 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 16/246 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026012 | Orentas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seattle Children's Hospital (dba Seattle Children's Research Institute (Seattle, Washington); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rimas J. Orentas (SEATTLE, Washington); Dimiter Stanchev Dimitrov (Pittsburgh, Pennsylvania); Wei LI (Pittsburgh, Pennsylvania); Du-Sun Baek (Pittsburgh, Pennsylvania) |
| ABSTRACT | Some embodiments of the methods and compositions provided herein include methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, antibody domain, CAR, cell engager, and/or ADC) to an FGFR4 polypeptide. For example, binders (e.g., antibodies, antigen binding fragments, antibody domains, CARs, cell engagers, and/or ADCs) acidic box that bind to an FGFR4 polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having cancer are provided. Some embodiments of the methods and compositions provided herein include chimeric antigen receptors (CARs) which specifically bind to fibroblast growth factor receptor 4 (FGFR4). Some embodiments include nucleic acids encoding such CARs, and cells containing such CARs. Some embodiments include the use of such CARs in safe and effective therapies for a cancer, such as an FGFR4-expressing cancer, such as a rhabdomyosarcoma. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 18/027305 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/4631 (20230501) A61K 2239/21 (20230501) A61K 2239/22 (20230501) Peptides C07K 16/2863 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0634 (20130101) C12N 15/86 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026016 | O'NEIL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Thomas O'NEIL (Nashville, Tennessee); Matthew Hunter WILSON (Brentwood, Tennessee) |
| ABSTRACT | Disclosed are compositions and methods relating to genetically modified cells for the long-term expression of an antigen of interest. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/344214 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/468 (20130101) C07K 16/2866 (20130101) Original (OR) Class C07K 2317/75 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026025 | Zettlitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirstin A. Zettlitz (Sherman Oaks, California); Anna M. Wu (Sherman Oaks, California); Robert E. Reiter (Los Angeles, California) |
| ABSTRACT | This invention relates to inhibition of the N-cadherin signaling using a humanized anti-N-cadherin antibody. In one embodiment, the invention relates to methods of treating an N-cadherin-mediated disease or N-cadherin-mediated disorder in a subject by contacting the subject with an anti-N-cadherin antibody. |
| FILED | Thursday, June 08, 2023 |
| APPL NO | 18/331623 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026027 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Bin Liu (San Francisco, California); James D. Marks (Kensington, California) |
| ABSTRACT | This invention provides a method that allows selection of antibodies against cells (e.g., tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented prostate cancer antigens. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/097133 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/1072 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/005 (20130101) C07K 16/18 (20130101) C07K 16/30 (20130101) C07K 16/2803 (20130101) C07K 16/3069 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) G01N 33/6845 (20130101) G01N 33/6854 (20130101) G01N 33/57434 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026031 | WELLS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. WELLS (Oakland, California); Adam D. COTTON (Oakland, California); Duy NGUYEN (Oakland, California); Katarina PANCE (Oakland, California) |
| ABSTRACT | The present disclosure relates to, among other things, methods for degrading targeted surface proteins using the ubiquitin pathway by using a bispecific binding agent or an immunoconjugate that binds the targeted surface protein and a membrane-associated ubiquitin E3 ligase. The present disclosure also relates to methods for degrading targeted surface proteins using the ubiquitin pathway using an engineered transmembrane protein that binds the targeted surface protein and exhibits ubiquitin E3 ligase activity. The disclosure also provides compositions and methods useful for producing such bispecific binding agents and engineered transmembrane proteins, immunoconjugates, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various diseases such as cancers. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/773283 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) A61K 47/6879 (20170801) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 16/2827 (20130101) C07K 2317/31 (20130101) C07K 2317/55 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026034 | LAKE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas LAKE (Scottsdale, Arizona); Thai HO (Scottsdale, Arizona); Calvin KOELBEL (Mesa, Arizona) |
| ABSTRACT | Provided are antibodies specific for human QSOX1 and methods of using these antibodies or antigen binding regions thereof in assays to detect QSOX1, to inhibit QSOX1, for use in other assay systems, and for use in treating cancer. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 18/257444 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/52 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026037 | SANTICH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian H. SANTICH (New York, New York); Mao WANG (New York, New York); Nai-Kong V. CHEUNG (New York, New York); Steven LARSON (New York, New York); Sarah CHEAL (New York, New York); Darren VEACH (New York, New York); Mahiuddin AHMED (New York, New York); Hong XU (New York, New York) |
| ABSTRACT | The present disclosure relates generally to immunoglobulin-related compositions (e.g., multi-specific antibodies or antigen binding fragments thereof) that can bind to the GPA33 protein. The multi-specific antibodies of the present technology are useful in methods for detecting and treating a GPA33-associated cancer in a subject in need thereof. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 18/253319 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/468 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/31 (20130101) C07K 2317/52 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026261 | HUH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongeun HUH (Villanova, Pennsylvania); Sunghee Estelle PARK (Philadelphia, Pennsylvania) |
| ABSTRACT | The disclosed subject matter provides techniques for culturing organoids or cells. A device for culturing organoids can include an access port configured to receive a solution, a loading chamber, wherein the access port is located in the loading chamber, and a plurality of culture chambers, wherein the culture chambers are radiated from the loading chamber so that the solution injected into the loading chamber through the access port is distributed into the plurality of culture chambers, wherein the plurality of culture chambers are open to an external environment and comprises a protruding edge at an opening of the plurality of culture chambers. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 18/255398 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/12 (20130101) C12M 23/22 (20130101) C12M 23/34 (20130101) C12M 25/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026263 | Collins |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John Collins (Irvine, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Collins (Irvine, California) |
| ABSTRACT | Gravity-driven microfluidic system provides unidirectional physiological flow in cells, organs, multi-organs and organoids culture. Such gravity-driven flow is integrated in multi-organ system on a plate or multi-organ system on a chip to provide recirculations that simulates blood flow in humans. In addition, mechanical actuations on the organs provide true human on a chip or true human on a plate platform. Stretching of the organ substrate using gas at controlled pressure profile provides muscular stimulation and culturing the stretched organ at air/media or gas/liquid interface is useful for organ simulations. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/477549 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 23/40 (20130101) C12M 41/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026265 | Allbritton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy L. Allbritton (Seattle, Washington); Christopher E. Sims (Seattle, Washington); Yuli Wang (Lynnwood, Washington); Pavak Kirit Shah (Carrboro, North Carolina) |
| ABSTRACT | An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe). |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/216230 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/00452 (20130101) B01J 2219/00743 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) Original (OR) Class C12M 23/20 (20130101) C12M 23/22 (20130101) C12M 25/04 (20130101) C12M 25/16 (20130101) C12M 47/02 (20130101) C12M 47/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/02 (20130101) C12N 5/0068 (20130101) C12N 2509/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026267 | Mao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leidong Mao (Watkinsville, Georgia); Yang Liu (Albany, California); Wujun Zhao (Waunakee, Wisconsin) |
| ABSTRACT | The present disclosure provides for microfluidic devices, systems, kits, and methods of using multi-stage microfluidic devices are provided for high throughput sorting, separation/enrichment of target rare cells from a sample, and can additionally provide for characterization/phenotyping of circulating tumor cells (CTCs) and other unlabeled rare cells in a biological sample such as blood, where the rare cells do not need to be labeled. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/224717 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/16 (20130101) C12M 35/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026270 | Allbritton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy Allbritton (Chapel Hill, North Carolina); Yuli Wang (Cary, North Carolina); Hennayaka Mudiyanselage Dulan Gunasekara (Carrboro, North Carolina); Christopher Sims (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention is directed to a method of making a live cell construct or a support, comprising: (a) providing a non-cellular organic polymer support having a top surface, a bottom surface, and an intermediate portion there between, and (b) contacting a cross-linking agent to one surface of said support for a time sufficient to generate a gradient of cross-linking of said polymer in said intermediate portion. Also provided are live cell constructs, supports, and methods of use of the supports and live cell constructs. |
| FILED | Tuesday, July 11, 2023 |
| APPL NO | 18/220535 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/20 (20130101) C12M 25/14 (20130101) Original (OR) Class C12M 35/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0679 (20130101) C12N 2513/00 (20130101) C12N 2533/54 (20130101) C12N 2537/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026293 | June et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl H. June (Merion Station, Pennsylvania); Michael Milone (Cherry Hill, New Jersey); Yangbing Zhao (Lumberton, New Jersey); Lawrence G. Lum (Charlottesville, Virginia); Archana Thakur (Charlottesville, Virginia) |
| ABSTRACT | The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an intracellular signaling molecule in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity. |
| FILED | Tuesday, April 18, 2023 |
| APPL NO | 18/135836 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/4748 (20130101) C07K 14/7051 (20130101) C07K 16/32 (20130101) C07K 16/2863 (20130101) C07K 16/2887 (20130101) C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026302 | THOMSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. THOMSON (Madison, Wisconsin); Jue ZHANG (Madison, Wisconsin) |
| ABSTRACT | Methods for generating human arterial endothelial cells under defined conditions in the absence of insulin are described. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/310510 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0031 (20130101) C12N 5/0056 (20130101) C12N 5/069 (20130101) Original (OR) Class C12N 2500/35 (20130101) C12N 2500/90 (20130101) C12N 2500/98 (20130101) C12N 2501/10 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/42 (20130101) C12N 2501/113 (20130101) C12N 2501/155 (20130101) C12N 2501/165 (20130101) C12N 2501/415 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026315 | Barnes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DNA POLYMERASE TECHNOLOGY, INC. (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne M. Barnes (University City, Missouri); Milko B. Kermekchiev (St. Louis, Missouri); Zhian Zhang (Ballwin, Missouri) |
| ABSTRACT | Provided are mutant polymerases having DNA polymerase activity and reverse transcriptase activity or strand displacement activity, along with target nucleic acid amplification methods employing such mutant polymerases. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/476104 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) Original (OR) Class C12N 9/1276 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6846 (20130101) C12Q 2521/101 (20130101) C12Q 2531/101 (20130101) C12Q 2531/119 (20130101) Enzymes C12Y 207/07007 (20130101) C12Y 207/07049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026323 | Doudna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); David Colognori (Berkeley, California) |
| ABSTRACT | The present disclosure provides methods of modifying a target RNA in a eukaryotic cell. The present disclosure provides methods detecting a target RNA in a eukaryotic cell. |
| FILED | Tuesday, June 20, 2023 |
| APPL NO | 18/338150 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026345 | Cohen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Barak Cohen (St. Louis, Missouri); Siqi Zhao (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of compositions for single-cell reporter assays and methods of use thereof. Also provided are methods of determining individual activities of a plurality of nucleic acid regulatory elements, identifying a regulatory element having cell type-specific activity, or determining variance in activity of a plurality of nucleic acid regulatory elements. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054503 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/1037 (20130101) Original (OR) Class C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026354 | Dixon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); Texas Heart Institute (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A.F. Dixon (Houston, Texas); Qi Liu (Houston, Texas); James T. Willerson (Houston, Texas); James F. Martin (Pearland, Texas) |
| ABSTRACT | Embodiments of the disclosure include methods for generating skeletal muscle by targeting the Hippo pathway. In particular embodiments, an individual with a need for skeletal muscle generation is provided an effective amount of a shRNA molecule that targets the SAV1 gene. Particular shRNA sequences are disclosed. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 18/037029 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026355 | Poss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Kenneth Poss (Durham, North Carolina); Ruorong Yan (Durham, North Carolina); Junsu Kang (Durham, North Carolina); Joseph Goldman (Durham, North Carolina); Valentia Cigliola (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are methods are compositions and methods for enhancing regeneration in stressed damaged, and/or injured tissues. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 18/037054 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2320/30 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026356 | Harper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Quenton Harper (Powell, Ohio); Afrooz Rashnonejad (Columbus, Ohio); Nicolas Sebastien Wein (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are products, methods, and uses for treating, ameliorating, udaying the progression of, and/or preventing a muscular dystrophy or a cancer including, but not limited to, facioscapulohumeral muscular dystrophy (FSHD) or a sarcoma. More particularly, disclosed herein are RNA interference-based products, methods, and uses for inhibiting or downregulating the expression of double homeobox 4 (DUX4). Even more particularly, the disclosure provides nucleic acids comprising U7 DUX4 antisense sequences for inhibiting or downregulating the expression of DUX4 and methods of using said antisense sequences to inhibit or downregulate DUX4 expression in cells and/or in cells of a subject having a muscular dystrophy or a cancer including, but not limited to, FSHD or a cancer. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 18/038878 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026381 | Perez-Pinera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Pablo Perez-Pinera (Mahomet, Illinois); Wendy Woods (Champaign, Illinois); Jackson Winter (Urbana, Illinois); Michael Gapinske (Urbana, Illinois) |
| ABSTRACT | The present disclosure provides prime editors, editor systems and methods of uses thereof. Specifically, the disclosure provides methods of use of split prime editors for editing genomic DNA. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 18/251505 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/11 (20130101) C12N 15/90 (20130101) Original (OR) Class C12N 2310/20 (20170501) Enzymes C12Y 207/07049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026382 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Soumya Kannan (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are systems, methods, and compositions capable of targeting nucleic acids. Describe in certain exemplary embodiments herein are a class of small Cas proteins (Type II-D Cas proteins) and systems thereof. Also described in certain exemplary embodiments herein are methods of modifying target sequences using the class of small Cas proteins (Type II-D Cas proteins) and systems thereof described herein. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470189 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 15/90 (20130101) Original (OR) Class C12N 15/102 (20130101) Enzymes C12Y 207/07049 (20130101) C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026396 | Buller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Andrew Buller (Madison, Wisconsin); Tyler Doyon (Eau Claire, Wisconsin); Samantha Bruffy (Madison, Wisconsin); Anthony Meza (Madison, Wisconsin) |
| ABSTRACT | A method to make tertiary β-hydroxy α-amino acids. The method includes reacting a ketone substrate and a primary or secondary β-hydroxy α-amino acid with an L-threonine aldolase and/or an L-threonine transaldolase for a time, at a temperature, and at a pH wherein the reaction yields a tertiary β-hydroxy α-amino acid product. |
| FILED | Thursday, July 13, 2023 |
| APPL NO | 18/351559 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/06 (20130101) Original (OR) Class C12P 13/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026399 | LE MOAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Omniox, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natacha LE MOAN (San Francisco, California); Ana KRTOLICA (San Francisco, California); Philberta LEUNG (Portland, Oregon); Stephen P.L. CARY (San Mateo, California) |
| ABSTRACT | The invention provides H-NOX proteins for the delivery of oxygen to hypoxic tissue following stroke. H-NOX proteins extravasate into hypoxic penumbra associated with stroke and preferentially accumulate for sustained delivery of oxygen to the hypoxic tissue to ameliorate adverse affects of stroke related hypoxia. In some embodiments, the H-NOX comprises PEGylated H-NOX and non-PEGylated H-NOX. |
| FILED | Thursday, April 27, 2023 |
| APPL NO | 18/308203 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/1085 (20130101) C12N 15/8218 (20130101) C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/12 (20130101) Original (OR) Class Enzymes C12Y 101/01247 (20130101) C12Y 205/01059 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026418 | Dey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FRED HUTCHINSON CANCER CENTER (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neelendu Dey (Seattle, Washington); Samuel Minot (Seattle, Washington) |
| ABSTRACT | The present disclosure provides compositions and non-invasive methods for diagnosing and treating a subject at risk for developing, or having, or at risk for progressing on colorectal cancer (CRC) based on analysis of bacterial species in the gut microbiome of the subject. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/320878 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/10 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/118 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026421 | Dapprich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Generation Biotech, LLC (Lawrenceville, New Jersey) |
| ASSIGNEE(S) | Generation Biotech, LLC (Lawrenceville, New Jersey) |
| INVENTOR(S) | Johannes Dapprich (Lawrenceville, New Jersey); Karl P. Dresdner, Jr. (Haddonfield, New Jersey); Richard R. McKay (East Windsor, New Jersey) |
| ABSTRACT | The invention relates to methods for capturing a polynucleotide comprising a DNA target segment from a population of polynucleotide molecules. The method may use a mixture comprising the population of the polynucleotide molecules, one or more polynucleotide primers, nucleotides, biotinylated nucleotides, a polymerase enzyme and a buffered liquid medium. The method may denature the polynucleotide molecules in the mixture so as to create single stranded portions of the polynucleotide molecules which can be accessible to the polynucleotide primers; hybridizing the polynucleotide primers to the polynucleotide comprising the DNA target segment. The method may create an extended polynucleotide primer by using the nucleotides, the biotinylated nucleotides and the polymerase enzyme as a means for labeling with biotin and increasing the extent of hybridization of the extended polynucleotide primer to the polynucleotide comprising the DNA target segment. The method may add streptavidin-labeled magnetic beads to the mixture. The method may use a magnetic field to move the streptavidin-labeled magnetic beads relative to the buffered liquid medium as a means for increasing binding of the biotinylated nucleotides of the extended polynucleotide primer to the streptavidin-labeled magnetic beads. The method may use either a rotation of the magnetic field relative to the mixture or a rotation of the mixture relative to the magnetic field for causing a streptavidin-labeled magnetic bead rotation in the buffered liquid medium as a means for performing the steps of increasing the binding of the biotinylated nucleotides of the extended polynucleotide primer to the streptavidin-labeled magnetic beads and increasing the winding of the biotinylated nucleotides of the extended polynucleotide primer onto the streptavidin-labeled magnetic beads, so as to increase the probability of capturing a long polynucleotide comprising a DNA target segment and so as to increase the probability of preventing damage to the long polynucleotide comprising a DNA target segment. Also the method may use a magnetic field to collect the streptavidin-labeled magnetic beads so as to capture the polynucleotide comprising the DNA target segment which is bound to the streptavidin-labeled magnetic beads. |
| FILED | Tuesday, July 11, 2023 |
| APPL NO | 18/220552 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54326 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026455 | Lundberg |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Father Flanagan's Boys' Home Doing Business as Boys Town National Research Hospital (Omaha, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yesha (Yunxia) W. Lundberg (Omaha, Nebraska) |
| ABSTRACT | The present disclosure relates generally to methods of diagnosing Benign Paroxysmal Positional Vertigo (BPPV) in a subject. In particular, the present disclosure relates to methods of genotyping a subject in order to determine the presence or absence of a genetic variation or variations indicative of BPPV. In other embodiments, an inhibitor is administered to a subject, wherein the inhibitor prevents aggregation of proteins in neural cells such as the vestibular ganglia. The disclosure further includes methods of identifying an agent that inhibits the aggregation of proteins in neural cells. Methods of monitoring protein aggregation in neural cells are also provided. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356417 |
| CURRENT CPC | Peptides C07K 16/18 (20130101) C07K 2317/32 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026456 | DE VLAMINCK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Iwijn DE VLAMINCK (Ithaca, New York); John Richard LEE (Ithaca, New York); Philip Smith BURNHAM (Ithaca, New York); Alexandre Pellan CHENG (Ithaca, New York); Manikkam SUTHANTHRIAN (Ithaca, New York); Darshana M. DADHANIA (Ithaca, New York) |
| ABSTRACT | The present disclosure is directed to methods of detecting cell-free DNA (cfDNA) in biological samples and using it to quantify organ damage and identify pathogens. In some aspects, the biological samples are from patients who have undergone solid-organ transplantation. The disclosure is also directed to methods of detecting and analyzing methylation patterns in cell-free DNA from organ transplant patients to identify the presence of pathogens as well as quantify contributing tissue proportions as a measurement of the host response. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458199 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/701 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026460 | Kurtz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Carlos, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/167804 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 35/20 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026461 | Melnick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ari Melnick (New York, New York); Min Xia (New York, New York); Hao Wu (Brookline, Massachusetts); Liron David (Allston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ari Melnick (New York, New York); Min Xia (New York, New York); Hao Wu (Brookline, Massachusetts); Liron David (Allston, Massachusetts) |
| ABSTRACT | Methods are described herein for identifying and/or treating lymphoma patients that have one or more genomic mutations in a coding region of at least one BCL10 allele. Such patients can be resistant to commonly used cancer treatments and can benefit instead from treatment with at least one MALT1 inhibitor. |
| FILED | Friday, June 02, 2023 |
| APPL NO | 18/328226 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026463 | Trinidad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Camille V. Trinidad (Kansas City, Kansas); Harsh B. Pathak (Overland Park, Kansas); Mihaela Sardiu (Prairie Village, Kansas); Andrew K. Godwin (Leawood, Kansas) |
| ABSTRACT | A method of reporting a diagnoses of cancer in a subject is provided. The method can include obtaining a biological sample from the subject, and measuring a presence or amount of a combination of biomarkers in the biological sample. The combination of biomarkers includes ACSL4, IGSF8, ITGA2, ITGA5, ITGB3, and MYOF, and optionally STX4 and/or optionally FOLR1. The presence of the biomarkers in the sample indicates the presence of cancer cells in the subject, and/or an increased amount of the biomarkers in the sample indicates presence of cancer cells in the subject. The method can include determining whether the presence or amount of the combination of biomarkers indicates the presence of cancer cells in the subject, and then preparing a report on the presence of cancer cells in the subject. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356886 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/52 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027320 | Demirci et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Utkan Demirci (Cambridge, Massachusetts); Waseem Asghar (Boston, Massachusetts) |
| ABSTRACT | A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/371952 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/061 (20130101) C12N 5/0612 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4005 (20130101) G01N 15/00 (20130101) G01N 15/10 (20130101) Original (OR) Class G01N 2001/4088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027325 | Chiu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Daniel T. Chiu (Seattle, Washington); Yifei Jiang (Seattle, Washington); Mengxia Zhao (Seattle, Washington); Yuanhua Cheng (Seattle, Washington) |
| ABSTRACT | Systems and methods for analyzing particles flowing in a channel are described. In an embodiment, the channel is configured to flow a particle through a lumen of the channel, the channel defining an interrogation window configured to allow light to pass into and out of the lumen; a light engine comprising: a first light source positioned to output first excitation light onto a first portion of the channel in the interrogation window; and a second light source positioned to output second excitation light onto a second portion of the channel in the interrogation window separate from the first portion. In an embodiment, the systems include an emission fiber bundle comprising a first emission optical fiber and a second emission optical fiber, wherein a proximal end of first emission optical fiber and second emission optical fiber are arranged in an emission fiber bundle head. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 18/250613 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) Original (OR) Class G01N 2015/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027453 | Cristea et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Ileana M. Cristea (Princeton, New Jersey); Joel Federspiel (North Reading, Massachusetts); Michelle A. Kennedy (West Windsor, New Jersey) |
| ABSTRACT | Described are systems and assays that monitor presence and/or quantity of herpesviruses viral proteins. Embodiments offer accurate detection and quantification of viral proteins from all temporal classes of viral replication. Three exemplary assays provide specific detection of: herpes simplex vims type 1 (HSV1), human cytomegalovirus (HCMV), and Kaposi's sarcoma-associated herpesvirus (KSHV). These assays can be utilized in combination with drug treatments, genetic modifications, or other perturbations to assess the impact of the intervention on viral protein production. Also provided are kits for use with such assays, peptides useful in the describes assays (including labeled peptides and collections of a plurality of different peptides), nucleic acids and other genetic constructs encoding such peptides, systems for carrying out the described assays (including computer-based or computer-assisted systems), and methods for using the assays for instance in drug development and analysis, vaccine development and analysis, genetic analysis, environmental analysis, etc. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 18/006035 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56994 (20130101) Original (OR) Class G01N 2800/26 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027456 | Aghvanyan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| ASSIGNEE(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| INVENTOR(S) | Anahit Aghvanyan (Gaithersburg, Maryland); Eli N. Glezer (Del Mar, California); John Kenten (Boyds, Maryland); Sudeep Kumar (Hackettstown, New Jersey); Galina Nikolenko (Germantown, Maryland); Martin Stengelin (Gaithersburg, Maryland); Srikant Vaithilingam (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/376575 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) Original (OR) Class G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027458 | Kuhn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Kuhn (Solana Beach, California); Angel Ernesto Dago Rodriguez (La Jolla, California); Anders Carlsson (Los Angeles, California); Wei Liu (Chandler, Arizona); Jim Hicks (Lattingtown, New York) |
| ABSTRACT | The present invention provides methods for predicting response to a hormone-directed therapy or chemotherapy in a prostate cancer (PCa) patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) individually characterizing genotypic, morphometric and protein expression parameters to generate a profile for each of the CTCs, and (c) predicting response to hormone-directed therapy in the prostate cancer PCa patient based on said profile. In some embodiments, the methods comprise repeating steps (a) through (c) at one or more timepoints after initial diagnosis of prostate cancer to sequentially monitor said genotypic, morphometric and protein expression parameters. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/174015 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57434 (20130101) Original (OR) Class G01N 33/57488 (20130101) G01N 33/57492 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027460 | Gustafson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington); Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington); Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Heather Gustafson (Seattle, Washington); Rebecca Gardner (Seattle, Washington); Bobbie-Jo M. Webb-Robertson (Seattle, Washington); Katelyn Burleigh (Seattle, Washington) |
| ABSTRACT | The present disclosure relates to biomarker profiles and their use to predict a subject's response to an immunomodulatory treatment. Biomarkers in these profiles include cytokines and other proteins associated with the interleukin 1 family and the type 1 interferon family. Particular biomarkers include interleukin (IL)-2, soluble IL-2 receptor alpha (sIL-2RA), IL-5, IL-6, IL-9, IL-10, IL-18, IL-18 binding protein (IL-18BP), IL-18 receptor 1 (IL-18R1), IL-18 receptor accessory protein (IL-18RAP), IL-22, C-type lectin-like receptor (CD161), CD56, interferon gamma (IFNγ), granulocyte macrophage colony stimulating factor (GM-CSF), serum amyloid A (SAA), and C-reactive protein (CRP). Particular biomarkers also include populations of cells including CD161+ cells and CD56+dim cells. The biomarker profiles can be used to predict a subject's responsiveness to an immunomodulatory treatment (e.g., immunotherapy) before or after an immunomodulatory treatment has initiated and to direct treatment to yield responsive and non-toxic outcomes to the immunomodulatory treatment. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 18/253556 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) G01N 33/57488 (20130101) Original (OR) Class G01N 2333/54 (20130101) G01N 2333/555 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027465 | Reiner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Steven L. REINER (NewYork, New York); Brian S. HENICK (New York, New York); Naiyer A. RIZVI (New York, New York); Rohan MANIAR (New York, New York); The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Steven L Reiner (Mount Kisco, New York); Brian S Henick (Englewood, New Jersey); Naiyer A Rizvi (New York, New York); Rohan Maniar (West Windsor, New Jersey) |
| ABSTRACT | A method of treating a condition in a subject by improving the immune response of the subject comprising first determining the level of TCF1 in the subject to identify the subject as having an anti-PD-1 responder phenotype or an anti-PD-1 non-responder phenotype, then administering an anti-PD-1 treatment to a subject having an anti-PD-1 responder phenotype or a metabolic inhibitor prior to ant-PD-1 treatment to a subject having an anti-PD-1 non-responder phenotype. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 18/245797 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) Original (OR) Class G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027470 | Tarca et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wayne State University (Detroit, Michigan); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | Wayne State University (Detroit, Michigan); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Adi L. Tarca (South Lyon, Michigan); Piya Chaemsaithong (Shatin, China Hong Kong); Tinnakorn Chaiworapongsa (Grosse Pointe Park, Michigan); Sonia S. Hassan (Novi, Michigan); Roberto Romero (Grosse Pointe, Michigan) |
| ABSTRACT | Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482286 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/16 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Enzymes C12Y 304/24007 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/689 (20130101) Original (OR) Class G01N 2333/96494 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027481 | Czarnecki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NanoCytomics, LLC (Evanston, Illinois); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jarema Czarnecki (Evanston, Illinois); Justin Derbas (Evanston, Illinois); Sergey Rozhok (Evanston, Illinois); Hariharan Subramanian (Mundelein, Illinois); Parvathi Viswanathan (Evanston, Illinois) |
| ABSTRACT | Systems and methods that enable automated spray deposition of biological specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated specimen deposition systems and methods of generating high-quality, reproducible specimen-bearing microscope slides in automated processing systems. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/164918 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/312 (20130101) G01N 1/2813 (20130101) G01N 35/00029 (20130101) Original (OR) Class G01N 35/00871 (20130101) G01N 35/1011 (20130101) G01N 35/1065 (20130101) G01N 2001/317 (20130101) G01N 2035/00138 (20130101) G01N 2035/00168 (20130101) G01N 2035/00881 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027556 | METZGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory J. METZGER (Minneapolis, Minnesota); Xiaoxuan HE (Minneapolis, Minnesota); Simon SCHMIDT (Minneapolis, Minnesota) |
| ABSTRACT | A non-localized efficiency shimming technique is used to generate radio frequency (RF) shimming values for imaging with a multi-channel transmit RF coil that minimizes subject-specific imperfections in the transmit magnetic field (B1+) and reduces or eliminates signal dropout in the acquired images, while keeping the coil working in an optimal mode with a high transmit efficiency. The non-localized efficiency shimming can be used for both small and large fields-of-view where a specific ROI does not need to be specified. The static non-localized efficiency shim is advantageous for turbo spin echo (TSE) imaging of smaller anatomical targets, whereas the dynamic non-localized efficiency shim is advantageous for larger fields-of-view, such as in human torsos. |
| FILED | Monday, July 24, 2023 |
| APPL NO | 18/225556 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/543 (20130101) Original (OR) Class G01R 33/4818 (20130101) G01R 33/5608 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027558 | Mangia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Silvia Mangia (Minneapolis, Minnesota); Shalom Michaeli (Minneapolis, Minnesota); Djaudat Idiyatullin (Minneapolis, Minnesota); Gregor Adriany (Minneapolis, Minnesota); Mikko Kettunen (Minneapolis, Minnesota); Michael Garwood (Minneapolis, Minnesota); Olli Gröhn (Minneapolis, Minnesota) |
| ABSTRACT | Systems and methods for producing an image of a subject with a magnetic resonance imaging (MRI) system. The method includes acquiring first MRI data from the subject using a first coil having a first field of view (FOV), simultaneously with or sequentially with acquiring the first MRI data, acquiring second MRI data from the subject using a second coil having a second FOV that is non-overlapping with the first FOV, and reconstructing images of the subject from the first MRI data and the second MRI data. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/358676 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/543 (20130101) G01R 33/3664 (20130101) G01R 33/5608 (20130101) Original (OR) Class G01R 33/5611 (20130101) G01R 33/5616 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027614 | Urban et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew W. Urban (Rochester, Minnesota); Margherita Capriotti (San Diego, California); James F. Greenleaf (Rochester, Minnesota) |
| ABSTRACT | Shear wave elastography and/or other ultrasound imaging procedures are performed using a data acquisition technique in which data are acquired with high SNR while maintaining a high PRFe, using conventional clinical ultrasound scanners. In general, ultrasound data are acquired using plane waves at different angles, after which a time alignment process is applied to the acquired data. The time alignment uses interpolation to obtain data points at higher frame rates, and the time-aligned data is compounded to increase the SNR. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 18/044185 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/485 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/52022 (20130101) G01S 7/52034 (20130101) G01S 15/8995 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029266 | TAUBE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Janis Marie TAUBE (Baltimore, Maryland); Sandor SZALAY (Baltimore, Maryland) |
| ABSTRACT | A device may obtain field images of a tissue sample, apply, to the field images, spatial distortion and illumination-based corrections (including corrections for photobleaching of reagents) to derive processed field images, identify, in each processed field image, a primary area including data useful for cell or subcellular component characterization, identify, in the processed field images, areas that overlap with one another, and derive information regarding a spatial mapping of cell(s) and/or sub-cellular components of the tissue sample. Deriving the information may include performing segmentation based on the data included in the primary area of each processed field image, and obtaining flux measurements based on other data included in the overlapping areas. The device may cause the information to be loaded in a data structure to enable statistical analysis of the spatial mapping for identifying factors defining normal tissue structure, associated inflammatory or neoplastic diseases and prognoses thereof, and associated therapeutics. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356544 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/367 (20130101) Electric Digital Data Processing G06F 18/24 (20230101) Image Data Processing or Generation, in General G06T 3/4038 (20130101) G06T 5/006 (20130101) G06T 5/009 (20130101) G06T 7/11 (20170101) Original (OR) Class G06T 7/0014 (20130101) G06T 2200/24 (20130101) G06T 2207/10056 (20130101) G06T 2207/20076 (20130101) G06T 2207/20092 (20130101) G06T 2207/30024 (20130101) Image or Video Recognition or Understanding G06V 2201/03 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029828 | Savage et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Frank Savage (Berkeley, California); John James Desmarais (Berkeley, California); Luke Mcdonald Oltrogge (Berkeley, California); Abraham Isser Flamholz (Berkeley, California) |
| ABSTRACT | To reduce the total amount of linear sequence (DNA, RNA or other medium) required to encode a set of genetic elements, the present disclosure describes a computational method for compressing genetic information by finding one or more sequences that each mutually encode multiple genetic elements in the same stretch of sequence (a “co-encoding”). The computational method encodes each of the genetic elements in respective directed acyclic graphs (DAGs) or finite automatons (FAs), then encodes overlapping sequences between the DAGs or FAs in a second DAG or FA. Additional DAGs or FAs may be encoded for overlapping sequences that result from shifting the reading frame of the genetic elements relative to one another and switching the orientation of the elements. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 18/266111 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) Original (OR) Class G16B 50/50 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240023528 | Akbari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar S. Akbari (La Jolla, California); Nikolay Kandul (La Jolla, California) |
| ABSTRACT | Provided is a gene editing system comprising (i) a polynucleotide encoding an endonuclease under the control of an inducible expressing regulatory sequence; (ii) a guide polynucleotide targeting a female-essential genomic sequence that is required for female-specific viability, and (iii) a guide polynucleotide targeting a male sterility genomic sequence that is required for male-specific fertility. Additionally provided are insect eggs, an insects, and an insect populations, each of which is genetically modified by the gene editing system. Further provided are methods and compositions relating to producing such systems, insect eggs, insects, insect populations and uses thereof in reducing a wild-type insect population. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/926970 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0339 (20130101) Original (OR) Class A01K 2227/706 (20130101) Peptides C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/635 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240023644 | Kartalov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emil Paskalev Kartalov (Pacific Grove, California); ANDREW THOMAS VESEY WALDRON (ALLENTOWN, Pennsylvania) |
| ABSTRACT | A flexible, thermally-insulating composite article includes: a base layer; a plurality of teeth extending from the base layer; and grooves extending between the teeth to enable the teeth to converge. The composite article may be in the form of a pad insertable into a pocket associated with a wetsuit. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/224895 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/012 (20130101) Original (OR) Class A41D 31/065 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240023808 | Sherwood et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark B. Sherwood (Gainesville, Florida); Peng Jiang (Gainesville, Florida); Aaron David Webel (Gainesville, Florida) |
| ABSTRACT | Described herein are eye implants that can include a pressure-responsive material that can be capable of changing color in response to pressure exerted on it. Also described here are methods of implanting and using the eye implants described herein to monitor intraocular pressure in a subject. The pressure-responsive material can be used to diagnose and monitor human or animal subjects. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/375595 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/16 (20130101) Original (OR) Class A61B 5/0075 (20130101) A61B 5/686 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/16 (20130101) A61F 9/00781 (20130101) A61F 2250/0081 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024383 | CUBILLOS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Andres Fernando CUBILLOS (Cambridge, Massachusetts); James J COLLINS (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions and methods comprising engineered microorganisms and their use for locally degrading an antibiotic in the gastrointestinal tract to prevent or limit death of beneficial flora. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 18/255203 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/744 (20130101) Original (OR) Class A61K 38/50 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/746 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/46 (20210501) Enzymes C12Y 305/02006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024453 | PETSCH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CureVac SE (Tübingen, Germany); Sanofi Pasteur (Lyon, France) |
| ASSIGNEE(S) | CureVac SE (Tübingen, Germany); Sanofi Pasteur (Lyon, France) |
| INVENTOR(S) | Benjamin PETSCH (Tübingen, Germany); Edith JASNY (Stuttgart, Germany); Yves GIRERD-CHAMBAZ (Messimy, France) |
| ABSTRACT | The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Zika virus or a disorder related to such an infection. In particular, the present invention concerns a Zika virus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and vaccines. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/338612 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/385 (20130101) A61K 47/646 (20170801) A61K 47/6455 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024490 | Choudhary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Choudhary (Boston, Massachusetts); Veronika Shoba (Cambridge, Massachusetts); Arghya Deb (Cambridge, Massachusetts); Tuan Nguyen (Boston, Massachusetts); Sophia Lai (Boston, Massachusetts); Dhanushka Munkanatta Godage (Cambridge, Massachusetts); Praveen Tiwari (Boston, Massachusetts); Ashley Modell (Cambridge, Massachusetts); Sachini Siriwardena (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to bifunctional chemical conjugation molecules, which find utility as modifiers of target substrates. The present disclosure includes multifunctional compounds comprising an enzyme binding moiety, a chemical linker moiety, and a target binding moiety, which may further include an electrophilic reactive group. Molecules according to the present invention find use making substrate modifications such as post-translational modifications to proteins that are not the natural substrate of the enzyme. Diseases or disorders may be treated or prevented with molecules of the present disclosure. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/999364 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class A61K 47/545 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 1/1077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024566 | Kamen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean Kamen (Bedford, New Hampshire); Lee A. Batchelder (Auburn, New Hampshire) |
| ABSTRACT | An access assembly for administration of agent to a shallow delivery destination may comprise a body having a first exterior surface and a second exterior surface. The first exterior surface may be at a non-orthogonal angle to the second exterior surface. The body may have a passage extending therethrough to a corner formed between the first and second exterior surfaces. The assembly may further comprise an adhesive pad coupled to the second exterior surface. The assembly may further comprise a member having a flow path extending therethrough and a sharp bearing body including a number of microneedles coupled to an end of the member. The member may be disposed within the passage and in contact with at least one stop defined by the passage. The assembly may further comprise a coupler configured to couple with a cooperating coupler on a fluid flow conduit. |
| FILED | Tuesday, May 16, 2023 |
| APPL NO | 18/197962 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) Original (OR) Class A61M 5/1408 (20130101) A61M 39/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024838 | Mirkin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Kaitlin Marie Landy (Evanston, Illinois); Kyle Joseph Gibson (Evanston, Illinois) |
| ABSTRACT | A method of making colloidal crystals using seed programmable atom equivalents (PAEs) and growth programmable atom equivalents (PAEs) for at least two stage growth. The seed and growth PAEs each include nanoparticles functionalized with oligonucleotides with sticky ends. Seed PAEs have sticky ends adapted to hybridize to each other to form a first duplex, and growth PAEs have sticky ends adapted to hybridize to a respective ones of the seed PAEs and to each other to form second, third, and fourth duplexes. Using base mismatches in the sticky ends of the growth PAEs and a two stage cooling, the first duplex having a higher melting temperature than the other duplexes nucleate the seed PAEs as seeds in a first stage and remaining duplexes form in a second lower temperature stage for growth on the seeds. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/224997 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0043 (20130101) Original (OR) Class Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/17 (20220101) B22F 1/054 (20220101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024869 | Meacham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | John Meacham (St. Louis, Missouri); Arpita Bose (St. Louis, Missouri) |
| ABSTRACT | A micro-bioelectrochemical cell (μ-BEC) device is disclosed that includes from 4 to 96 microfluidically connected chambers, in which each chamber encloses a volume of about 1 μL to 2 μL. A working electrode, reference electrode, and counting electrode contacts each volume. The μ-BEC device includes a support layer coated with a working electrode layer, a microfluidics layer containing a plurality of wells, and an electrical layer containing the reference and counter electrodes. Methods of using the μ-BEC device to perform bioelectrochemical measurements of cells are also disclosed. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/476837 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2300/12 (20130101) B01L 2300/0645 (20130101) B01L 2300/0861 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025938 | BOTHE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); Merck Sharp and Dohme, LLC (Rahway, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jameson R. BOTHE (Rahway, New Jersey); Andrew Patrick Jude BRUNSKILL (Rahway, New Jersey); Mark LOCKWOOD (Johns Creek, Georgia); Justin Allen NEWMAN (Rahway, New Jersey); Manohar T. SAINDANE (Decatur, Georgia) |
| ABSTRACT | Novel crystalline forms of molnupiravir, including crystalline Forms I and II, which are crystalline forms of uridine 4-oxime 5′-(2-methylpropanoate), may be useful as antiviral agents, specifically as antiviral treatments for infections caused by Eastern Equine Encephalitis Virus (EEEV), Western Equine Encephalitis Virus (WEEV), and Venezuelan Equine Encephalitis Virus (VEEV), Chikungunya fever virus (CHIK), Ebola virus, influenza virus, respiratory syncytial virus (RSV), Zika virus, and coronaviruses, such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and, most recently, SARS-CoV-2 (also known as 2019-nCoV). |
| FILED | Friday, August 27, 2021 |
| APPL NO | 18/042982 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/2013 (20130101) A61K 9/2018 (20130101) A61K 9/2054 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/067 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026068 | Moore et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Jeffrey S. Moore (Savoy, Illinois); Philippe H. Geubelle (Champaign, Illinois); Nancy R. Sottos (Champaign, Illinois); Elizabeth C. Firestone (Midland, Michigan); Evan M. Lloyd (Maryville, Illinois) |
| ABSTRACT | A method of spontaneously patterning a polymer during frontal polymerization includes activating an initiation region of a monomer solution to reaction to initiate a polymerization reaction. A polymerization front is generated and propagates through the monomer solution in a radial or longitudinal direction away from the initiation region. The monomer solution is spontaneously heated downstream of the polymerization front by thermal transport away from the polymerization reaction. Once a localized region of the monomer solution reaches a temperature sufficient for spontaneous initiation of another polymerization reaction, a new polymerization front is generated and propagates through the monomer solution in a circumferential or transverse direction. The spontaneous heating of the monomer solution downstream of the polymerization front and the initiation of another polymerization reaction occurs cyclically, producing multiple new polymerization fronts and spatial variations in reaction temperature across the monomer solution. Once polymerization is complete, a spontaneously patterned polymer is formed. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 18/265141 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) Original (OR) Class C08G 2261/418 (20130101) C08G 2261/3324 (20130101) C08G 2261/3325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026114 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ting Xu (Berkeley, California); Christopher A. DelRe (Berkeley, California) |
| ABSTRACT | Systems and methods for programmable degradation of a plastic deploy a plastic comprising a nanoscopic dispersion of enzymes and configured to exploit enzyme active sites and enzyme-protectant interactions to provide processive depolymerization as the primary degradation pathway with expanded substrate selectivity to effect substantially complete depolymerization without substantial microplastics formation with partial polymer degradation. |
| FILED | Sunday, September 24, 2023 |
| APPL NO | 18/473252 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/105 (20130101) Original (OR) Class C08J 2367/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/20 (20130101) C12N 9/50 (20130101) Enzymes C12Y 301/01003 (20130101) C12Y 304/21064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026333 | WELTZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | JAMES S. WELTZ (Denver, Colorado); JOEL L. KAAR (Lafayette, Colorado); DANIEL K. SCHWARTZ (Boulder, Colorado); HECTOR SANCHEZ-MORAN (Boulder, Colorado) |
| ABSTRACT | A polymer brush composed of statistical copolymers of hydrophilic and hydrophobic monomers for enzyme immobilization. The heterogeneous polymer brushes stabilized four different lipases against high temperatures. Notably, the statistical copolymers stabilized the four lipases to a greater extent than a homopolymer brush. Additionally, in the case of Rhizomucor miehei lipase, statistical copolymers stabilized the enzyme to a greater extent than homopolymers of either hydrophilic or hydrophobic monomers. The resulting increase in high-temperature stability enabled significant improvements in catalytic rates by operating reactions at elevated temperatures, which is desirable for enzyme catalysis and sensing applications. Additionally, stabilization against elevated temperatures implies stabilization against non-aqueous solvents, which is of critical importance to numerous applications of biocatalysts. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 18/036678 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/20 (20130101) C12N 11/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026466 | Venturelli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Ophelia Venturelli (Madison, Wisconsin); Yu-Yu Cheng (Madison, Wisconsin); Zhengyi Chen (Madison, Wisconsin) |
| ABSTRACT | Cell-based DNA sensors, compositions comprising the cell-based DNA sensors, and methods of detecting DNA and cells. The cell-based DNA sensors include competent cells that include genetic circuits. Each genetic circuit includes homology arms separated by an interstitial region that comprises at least one element of a reporter switch and/or a kill switch. The compositions include one or more cell-based DNA sensors. The cell-based DNA sensors can be used to detect DNA and cells by the genetic circuits undergoing homologous recombination with target regions of target DNA to activate or deactivate the reporter switch and/or kill switch. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067194 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/902 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240026560 — MICROSTRUCTURAL SURFACE INCORPORATION OF PHASE CHANGE MATERIALS FOR THERMAL MANAGEMENT
| US 20240026560 | Luhrs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Claudia Catalina Luhrs (Pacific Grove, California); Forest Douglas Shaner (San Jose, California); Christopher James Anderson (Louisville, Nebraska) |
| ABSTRACT | A process for protecting an article from thermal damage includes anodizing a metallic surface of the article to form an anodic layer containing a metal oxide; annealing the anodic layer; introducing a phase change material to pores defined by the anodic layer; and applying a seal layer to seal the phase change material within the pores. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/226130 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 11/246 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026575 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Satish Kumar (Atlanta, Georgia); Han Gi Chae (Atlanta, Georgia); Bradley A. Newcomb (Atlanta, Georgia); Prabhakar V. Gulgunje (Atlanta, Georgia); Yaodong Liu (Atlanta, Georgia); Kishor K. Gupta (Atlanta, Georgia); Manjeshwar G. Kamath (Atlanta, Georgia) |
| ABSTRACT | In a method of making a carbon fiber, PAN (poly(acrylonitrile-co methacrylic acid)) is dissolved into a solvent to form a PAN solution. The PAN solution is extruded through a spinneret, thereby generating at least one precursor fiber. The precursor fiber is passed through a cold gelation medium, thereby causing the precursor fiber to gel. The precursor fiber is drawn to a predetermined draw ratio. The precursor fiber is continuously stabilized to form a stabilized fiber. The stabilized fiber is continuously carbonized thereby generating the carbon fiber. The carbon fiber is wound onto a spool. A carbon fiber has a fiber tensile strength in a range of 5.5 GPa to 5.83 GPa. The carbon fiber has a fiber tensile modulus in a range of 350 GPa to 375 GPa. The carbon fiber also has an effective diameter in a range of 5.1 μm to 5.2 μm. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/373557 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 33/20 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/09 (20130101) D01F 9/22 (20130101) D01F 9/225 (20130101) Original (OR) Class Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/02 (20130101) D02G 3/16 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/12 (20130101) D10B 2401/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026802 | Direnzi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Direnzi (Cincinnati, Ohio); Bernard J. Renggli (Cincinnati, Ohio) |
| ABSTRACT | A protector for attachment to and protection of a leading edge of a protective liner of an aircraft engine component includes a clip portion including a channel for receiving a portion of the protective liner including the leading edge of the protective liner. The clip portion includes at least one spacer extending therefrom to create at least one air flow gap between the clip portion of the protector and an upstream liner of the aircraft engine when the upstream liner is positioned in abutment with the at least one spacer of the clip portion. The protector includes a flange portion extending from the clip portion and including a through aperture configured to receive a portion of a fastener passing through both the aperture and at least a portion of the protective liner to attach the protector to the protective liner. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868063 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/24 (20130101) Original (OR) Class F01D 25/28 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2240/14 (20130101) F05D 2250/75 (20130101) F05D 2260/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027704 | WOOD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AirBorn Inc. (Georgetown, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lance A. WOOD (Winter Park, Colorado); Harsha Krishna KOPURU (Parker, Colorado); Rebekah Jean MITCHELL (Littleton, Colorado); Jason Paul SMITH (Sartell, Minnesota); Timothy John WASLAND (Little Falls, Minnesota) |
| ABSTRACT | A space active optical cable (SAOC) includes a cable including one or more optical fibers, and two or more electrical transceivers on opposing ends of the cable and interconnected by the cable. Each of the electrical transceivers includes an enclosure that encloses one or more light sources, one or more light detectors, and control electronics. Also included in the enclosure are a coupling medium to couple light into and out of the one or more optical fibers. The coupling medium can be reflecting surface or an on-axis mount. The enclosure provides a suitable heat propagation and electromagnetic interference (EMI) shielding, and the cable and the two or more electrical transceivers are radiation resistant. SAOC features optionally support a health check algorithm that allows trending optical performance in the absence of an optical connector and a potential surface treatment to increase nominally low emissivity of an EMI conductive surface. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/225902 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/428 (20130101) G02B 6/4206 (20130101) G02B 6/4214 (20130101) G02B 6/4246 (20130101) Original (OR) Class G02B 6/4267 (20130101) G02B 6/4277 (20130101) G02B 6/4284 (20130101) G02B 6/4286 (20130101) G02B 6/4415 (20130101) Transmission H04B 10/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028396 | Reid |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Reid (Ayer, Massachusetts) |
| ABSTRACT | A method includes obtaining thermal information and latency information associated with multiple components of at least one semiconductor chip. The latency information identifies multiple latencies associated with multiple applications to be executed by the components of the at least one semiconductor chip. The method also includes scheduling, using a run-time scheduler on the at least one semiconductor chip, execution of the multiple applications by the components of the at least one semiconductor chip. The run-time scheduler utilizes the thermal information and the latency information along with run-time events to determine which components of the at least one semiconductor chip execute the applications over time. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/364634 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4893 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028533 | Reid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Reid (Ayer, Massachusetts); Sandeep Dutta (Foster City, California) |
| ABSTRACT | A method includes obtaining behavioral source code defining logic to be performed using at least one logic device and constraints identifying data movements associated with execution of the logic. The at least one logic device contains multiple components that support at least one of: internal data movements within the at least one logic device and external data movements external to the logic device as defined by the behavioral source code and the constraints. The constraints identify characteristics of at least one of: the internal data movements and the external data movements. The method also includes automatically designing one or more data movers for use within the at least one logic device, where the one or more data movers are configured to perform at least one of the internal and external data movements in accordance with the characteristics. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/364481 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3867 (20130101) Original (OR) Class G06F 9/30145 (20130101) G06F 13/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028815 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiangyong Wang (San Jose, California); David Kehlet (Los Altos Hills, California); Diana Cristina Ojeda Aristizabal (Toronto, Canada); Ian Kuon (Toronto, Canada); Mehmet Avci (Toronto, Canada) |
| ABSTRACT | Integrated circuit devices, methods, and circuitry are provided for performing timing analysis for chip-to-chip connections between integrated circuits in a multichip package. A system may include an integrated circuit package and a computing system. The integrated circuit package may have a first integrated circuit connected to a second integrated circuit via a chip-to-chip connection. The chip-to-chip connection may also be connected to a package ball. The computing system may perform timing analysis on a circuit design for the first integrated circuit with respect the chip-to-chip connection based on user-specified parasitic data relating to the connection to the package ball. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/375299 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/398 (20200101) Original (OR) Class G06F 2119/12 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028882 | Hopkins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Jonathan Brigham Hopkins (Los Angeles, California); Erwin A.B. Mulder (Nieuwegein, Netherlands); Ryan Hansen Lee (Los Angeles, California) |
| ABSTRACT | A beam for use in a lattice of beams of a mechanical neural-network (MNN) which can form a metamaterial configured to learn a set of properties by exposure to continuous external loads. Each beam of the lattice is configured to change its stiffness in response to external load input. A lattice of the MNNs is configured to learn by tuning the stiffness of its constituent beams in the MNN. The lattice can be either two or three dimensional, and configured to occupy volumes of arbitrary shape. The MNN has multiple layers of nodes, wherein each said node is analogous to the neurons within an artificial neural network. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356351 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028884 | MORAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Steven L. MORAN (Los Angeles, California); Subramanian S. IYER (Los Angeles, California); Zhe WAN (Los Angeles, California); Sudhakar PAMARTI (Los Angeles, California) |
| ABSTRACT | Present implementations can include a system with a transistor array including a plurality of charge-trap transistors, the charge-trap transistors being operatively coupled with corresponding input nodes, and a neural integrator including a first integrator node and a second integrator node operatively coupled with the transistor array, and generating an output corresponding to a neuron of a neural network system. Present implementations can include a neural integrator with a first integrator node operatively coupled with a first charge-trap transistor of a transistor array, a second integrator node operatively coupled with a second charge-trap transistor of the transistor array, the second charge-trap transistor being operatively coupled with the first charge-trap transistor, and a capacitor operatively coupled with the first integrator node and the second integrator node, and operable to generate an output based on a first voltage at the first integrator node and a second voltage at the second integrator node. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 18/255346 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/065 (20230101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/792 (20130101) Electronic Memory Devices H10B 43/00 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028939 | Akhalwaya et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ismail Yunus Akhalwaya (Emmarentia, South Africa); Shashanka Ubaru (Ossining, New York); Kenneth Lee Clarkson (Madison, New Jersey); Mark S. Squillante (Greenwich, Connecticut); Vasileios Kalantzis (White Plains, New York); Lior Horesh (North Salem, New York) |
| ABSTRACT | A quantum computer-implemented system, method, and computer program product for quantum topological domain analysis (QTDA). The QTDA method achieves an improved exponential speedup and depth complexity of O(n log(1/(δ∈))) where n is the number of data points, ∈ is the error tolerance, δ is the smallest nonzero eigenvalue of the restricted Laplacian, and achieves quantum advantage on general classical data. The QTDA system and method efficiently realizes a combinatorial Laplacian as a sum of Pauli operators; performs a quantum rejection sampling and projection approach to build the relevant simplicial complex repeatedly and restrict the superposition to the simplices of a desired order in the complex; and estimates Betti numbers using a stochastic trace/rank estimation method that does not require Quantum Phase Estimation. The quantum circuit and QTDA method exhibits computational time and depth complexities for Betti number estimation up to an error tolerance ∈. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863524 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029410 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Chen (Stanford, California); John Galeotti (Pittsburgh, Pennsylvania); Howie Choset (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided is a method of training a machine-learning-based artificial intelligence (AI) model to handle diverse types of motions occurring during image acquisition, including capturing image data including motion between an imaging device and tissue, modifying the captured image data, resulting in modified image data, by at least one of: altering an amount of time between any two frames; removing a subsequence of frames from the captured image data; and adding a subsequence of one or more new frames to the captured image data, and training a machine-learning-based AI model based on the modified image data. Other systems and methods are also described. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 18/036737 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0464 (20230101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/774 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029911 | Lukin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mikhail D. Lukin (Cambridge, Massachusetts); Vladan Vuletic (Cambridge, Massachusetts); Markus Greiner (Cambridge, Massachusetts); Ruben Verresen (Cambridge, Massachusetts); Ashvin Vishwanath (Cambridge, Massachusetts); Alexander Keesling Contreras (Cambridge, Massachusetts); Harry Jay Levine (Cambridge, Massachusetts); Giulia Semeghini (Cambridge, Massachusetts); Tout Taotao Wang (Cambridge, Massachusetts); Ahmed Omran (Cambridge, Massachusetts); Dolev Bluvstein (Cambridge, Massachusetts); Sepehr Ebadi (Cambridge, Massachusetts) |
| ABSTRACT | Topological qubits are provided in a quantum spin liquid. In various embodiments, a device is provided comprising a two-dimensional array of particles, each particle disposed at a vertex of a ruby lattice having a parameter ρ greater than |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/320708 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) G06N 10/70 (20220101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029915 | Ganguli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sabyasachi Ganguli (Beavercreek, Ohio); Ajit K Roy (Beavercreek, Ohio); Chenggang Chen (Beavercreek, Ohio) |
| ABSTRACT | An electrically conductive, flexible, strain resilient product is produced by mixing metal coated carbon nanotube networks with a liquid polymeric resin to produce a liquid mixture, and the mixture is cured to produce the product. The networks may include welded junctions between nanotubes formed by depositing and melting metal nanoparticles on the nanotubes to form the metal coating. After the mixing step the liquid mixture may be deposited on a flexible substrate in the form of an electrical circuit. The mixing step may further include mixing the composite with a volatile solvent to produce a selected viscosity. Then, a three-dimensional printer may be used to print the product, such as an electrical circuit, on a substrate. The product is cured in an atmosphere that absorbs the solvent. The conductivity of the mixture may be adjusted by adjusting the weight percentage of the metal coated carbon nanotube networks from 50% to 90%, but a preferred range is between 75% and 85%. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/481510 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/18 (20220101) B22F 2302/403 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030362 | JIANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng JIANG (Gainesville, Florida); Zhuxiao GU (Gainesville, Florida); Ruwen TAN (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for methods of making substrates having an (AR) antireflective layer, substrates having an antireflective layer, devices including a substrate having an antireflective layer, and the like. The AR layer can have a total specular reflection of less than 10% at a wavelength of about 400-800 nm, and a height of about 500-1000 nm. |
| FILED | Tuesday, May 30, 2023 |
| APPL NO | 18/203436 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/118 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/186 (20130101) H01L 31/02168 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030572 | Hammond et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Christopher Hammond (Bloomington, Indiana); Lawrence S. Pate (Solsberry, Indiana) |
| ABSTRACT | A containment apparatus for collecting electrolyte from a battery relief vent is provided. The containment apparatus includes a body comprising a reservoir, a relief vent aperture, an internal baffle, and an upper vent aperture; a push-on connection that attaches the relief vent aperture to the battery relief vent; and a viewing window on an external side of the body. The containment apparatus attaches to a pressure relief vent on a battery to capture droplets of electrolyte that are released from the battery relief vent. Liquid electrolytes travel through the relief vent aperture and into the reservoir, and vaporized electrolyte condenses on the baffle and falls into the reservoir as droplets or travels past the baffle and is directed through the upper vent aperture via the walls. The device prevents electrolytes from accumulating on the outside of the battery and associated hardware within the vicinity of the battery. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/215879 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/691 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030887 | Ayazi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Farrokh Ayazi (Atlanta, Georgia); Benoit Hamelin (Atlanta, Georgia); Jeremy Yang (Atlanta, Georgia) |
| ABSTRACT | A resonator element of the monocrystalline 4H or 6H polytype of silicon carbide. A MEMS device including the resonator element and a substrate, wherein the resonator element and the substrate are not coplanar, and acoustic decoupling of the resonator element and the substrate is at least partially dependent upon a degree to which the resonator element and the substrate are not coplanar. A MEMS gyroscope including the resonator element, a substrate, one or more electrodes disposed proximate the resonator element, and a capacitive gap disposed between each electrode and the resonator element. A MEMS device including the resonator element having has a Q greater than 1,000,000, a phononic crystal substrate, and a gap disposed between a perimeter edge of the resonator element and the phononic crystal substrate, wherein acoustic decoupling of the resonator element and the phononic crystal substrate is at least partially dependent upon a size of the gap. |
| FILED | Thursday, August 17, 2023 |
| APPL NO | 18/451675 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/5698 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/02338 (20130101) H03H 9/02433 (20130101) Original (OR) Class H03H 9/2436 (20130101) H03H 2009/0244 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240031052 | ROBERTS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory D. ROBERTS (Alhambra, California); Andrei FARAON (Pasadena, California) |
| ABSTRACT | Methods and devices to split electromagnetic waves across broad bandwidths in correspondence with orbital angular momentum states combined with orthogonal polarization states are disclosed. The described methods can be used in fiber communication and imaging systems. The devices include three-dimensional (3D) scattering structures that can be using existing CMOS processes and direct write lithography techniques. Performance metrics based on the intensity and contrast of the split electromagnetic waves are also disclosed. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/346061 |
| CURRENT CPC | Multiplex Communication H04J 14/04 (20130101) H04J 14/07 (20230801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240031118 | Hua |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingbo Hua (Riverside, California) |
| ABSTRACT | A method for wireless communication between a node A and a node B provides physical layer security. The node A has disjoint non-empty sets of antennas A1 and A2. The node B has disjoint sets of antennas B1 and B2, where B1 is non-empty. The method involves the steps of transmitting a first pilot signal from B using only B1; receiving the first pilot signal by the node A using A2; performing by A carrier synchronization and channel estimation based on the first pilot signal; transmitting a second pilot signal by the node A using A1; transmitting an information signal by the node A using A2; receiving the second pilot signal by the node B using both B1 and B2; performing by B carrier synchronization based on the second pilot signal; and receiving the information signal by B using both B1 and B2. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/224001 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 5/16 (20130101) Original (OR) Class H04L 5/0048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240031395 | Kiss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sentar, Inc. (Huntsville, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter A. Kiss (Huntsville, Alabama); Kevin Scott Kuczynski (San Antonio, Texas); Samer Vishnu Patel (Toney, Alabama); Deborah A. Williams (Manitou Springs, Colorado); Timothy R. Westran (Mount Pleasant, South Carolina); Gary N. Mayes (Madison, Alabama) |
| ABSTRACT | The present disclosure generally pertains to cyber-attack resiliency assessment systems and methods. In some embodiments, the system may be configured to assess susceptibility of an operational system and its components to specific cyber-attacks and predict an impact of such attacks and impact to a mission which the operational system is intended to perform and complete. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200386 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/22 (20130101) H04L 63/1416 (20130101) H04L 63/1433 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240031521 | Caulfield et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cyan Systems (Santa Barbara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Caulfield (Santa Barbara, California); Jon Paul Curzan (Arroyo Grande, California) |
| ABSTRACT | A method that can detect targets is described. The method includes setting an integration time for each of a plurality of readout circuits based on a speed of the target. The readout circuits are configured to read pixels in an image detector. The pixels have a pitch of less than ten micrometers. The integration time is not more than five hundred microseconds and corresponds to a subframe of a fast frame image. The method also includes performing integrations of each readout circuit based on the integration time. Thus, a plurality of subframes are provided. A number of the subframes are averaged to provide the fast frame image. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/118691 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/248 (20170101) G06T 2207/10048 (20130101) G06T 2207/20212 (20130101) Image or Video Recognition or Understanding G06V 10/255 (20220101) Pictorial Communication, e.g Television H04N 5/33 (20130101) Original (OR) Class H04N 25/53 (20230101) H04N 25/75 (20230101) H04N 25/533 (20230101) H04N 25/587 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240031546 | Drexler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Robert Drexler (San Diego, California); Benjamin Laxton (San Diego, California) |
| ABSTRACT | A homodyne encoder encodes light sampled from an object with respective primary apertures for each spectral band. The multi-band homodyne encoder includes an optical spreader and a focusing optic. The optical spreader spreads apart the light from the respective primary apertures for each spectral band to respective secondary apertures for each spectral band. The optical spreader is arranged to spread, for each spectral band, the light from each one of the primary apertures for the spectral band to a respective one of the secondary apertures for the spectral band. The focusing optic focuses the light from the secondary apertures for all of the spectral bands into one or more composite images of the object. For each spectral band, every pairing of two of the primary apertures for the spectral band contributes distinct spatial frequencies to the composite image or images of the object. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/873010 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 13/214 (20180501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240032189 | OZDOGANLAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | O. Burak OZDOGANLAR (Sewickley, Pennsylvania); Carmel MAJIDI (Pittsburgh, Pennsylvania); Kadri Bugra OZUTEMIZ (Pittsburgh, Pennsylvania); James WISSMAN (Hyattsville, Maryland) |
| ABSTRACT | Manufacturing technology to fabricate liquid metal-based soft and flexible electronics (sensors, antennas, etc.) in a high-throughput fashion, with fabrication rates that may approach that of the traditional integrated circuit components and circuits, are described. The technique allows creation of liquid-metal-only circuits, as well as seamless integration of solid IC chips into the circuits, in which liquid metal traces are used as flexible interconnects and/or as other circuit elements. The process may be applied at the wafer scale and may be integrated into the traditional microelectronics fabrication processes. Many sensors, antennas, and other circuit elements may be directly created using liquid metal, and when combined with the IC chips, a broad range of electronic functionality may be provided in a flexible, soft circuit that can be conformable, wearable. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/376877 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/4846 (20130101) H01L 23/4985 (20130101) Antennas, i.e Radio Aerials H01Q 1/364 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0283 (20130101) Original (OR) Class H05K 3/388 (20130101) H05K 3/1208 (20130101) H05K 3/1216 (20130101) H05K 3/1241 (20130101) H05K 3/1258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240024822 | MERRILL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LUNA INNOVATIONS INCORPORATED (Roanoke, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew MERRILL (Roanoke, Virginia); Jesse KELLY (Roanoke, Virginia) |
| ABSTRACT | Dual phase membranes include a porous support providing a solid phase having a matrix of connected pores, and a liquefiable ion transport phase within the pores of the porous support. The ion transport phase is formed of at least one alkali metal hydroxide, and at least one oxide ion transport agent providing a source of ions selected from the group consisting of borate ions, nitrate ions, phosphate ions, vanadate ions, niobate ions or sulfate ions. The at least one alkali metal hydroxide may be selected from the group consisting of NaOH, KOH, LiOH, RbOH, CsOH and mixtures thereof. The oxide ion transport agent is preferably present in the ion transport phase in an amount between about 1 to about 30 molar %. Substantially lower operational temperatures may be realized when the membrane is used to separate CO2 from a feed gas. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 18/021758 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 61/38 (20130101) Original (OR) Class B01D 69/106 (20220801) B01D 69/108 (20220801) B01D 2257/504 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024823 | Lucas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Eowyn Lucas (Los Angeles, California); Harry A. Atwater (South Pasadena, California); Chengxiang Xiang (San Marino, California) |
| ABSTRACT | Systems and methods for catalyzed asymmetric bipolar membranes are described. Catalyzed asymmetric bipolar membranes can sustain desired current densities under low operational voltage for prolonged time periods. Catalyzed asymmetric bipolar membranes can be implemented in electrodialysis cells for various applications such as carbon capture. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/343597 |
| CURRENT CPC | Separation B01D 61/445 (20130101) Original (OR) Class B01D 61/461 (20220801) B01D 69/02 (20130101) B01D 2313/345 (20130101) B01D 2325/04 (20130101) B01D 2325/42 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/4693 (20130101) C02F 2101/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024848 | Velasquez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Ever O. Velasquez (Berkeley, California); Mercedes K. Taylor (Berkeley, California); Colin A. Gould (Berkeley, California); Jeffrey R. Long (Lafayette, California) |
| ABSTRACT | Metal organic frameworks are provided that exhibit a reversible phase change from a collapsed state to an expanded state. Due to this material property, these adsorbents exhibit stepped isotherms that have relevance in chemical storage and separations. The metal organic framework is M(LDP), where M is a metal selected from the group of Zn, Fe or Co and L is a ligand selected from the group of 1,4-benzenedipyrazolate (H2BDP), 2,5-pyridinedipyrazolate (H2PyDP), 2,5-pyrimidinedipyrazolate (H2PymDP), 2,5-pyrazinedipyrazolate (H2PyzDP), and 3,6-pyridazinedipyrazolate (H2PydDP). The step pressure position in the isotherm was changed by using nitrogen instead of carbon in the ring allowing for tunable aromatic interactions. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/358466 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/204 (20130101) B01D 2257/102 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 3/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024850 | Pang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon Hoching Pang (Fremont, California); Melinda Lia Wah Jue (Livermore, California) |
| ABSTRACT | A product includes an aminopolymer material formed into a self-supporting structure, the aminopolymer material including crosslinked aminopolymers having amine sites for the capture of carbon dioxide molecules. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/376390 |
| CURRENT CPC | Separation B01D 53/62 (20130101) B01D 53/81 (20130101) B01D 53/96 (20130101) B01D 2253/34 (20130101) B01D 2253/202 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) Original (OR) Class B01J 20/3064 (20130101) B01J 20/3085 (20130101) B01J 20/3425 (20130101) B01J 20/3483 (20130101) B01J 20/3491 (20130101) B01J 20/28033 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/50 (20170801) C01B 2210/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024852 | BACHMAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PALO ALTO RESEARCH CENTER INCORPORATED (PALO ALTO, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JONATHAN BACHMAN (Fremont, California) |
| ABSTRACT | A polymer aerogel monolith comprising a polymer aerogel having a nitrogen content of greater than seven weight percent impregnated into a mesh. A method of manufacturing an amine-containing polymer aerogel monolith, includes combining a vinyl-containing cross-linking monomer, a vinyl-containing functional monomer, an organic solvent, and a radical initiator into a liquid mixture, applying the liquid mixture to a mesh fabric to produce a monomer-impregnated mesh, heating the monomer-impregnated mesh to produce a polymer aerogel monolith, washing the polymer aerogel monolith with acid to produce an ammonium-containing polymer aerogel monolith, and applying a base to neutralize the ammonium-containing polymer aerogel monolith to produce an amine-containing polymer aerogel monolith. A direct air capture module has one or more amine-containing polymer aerogel monoliths, one or more air flow channels positioned to pass air through the monolith A monolith comprising a poly(alkylamine-co-divinylbenzene) impregnated mesh. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871131 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/25 (20130101) B01D 2253/202 (20130101) B01D 2253/306 (20130101) B01D 2253/342 (20130101) B01D 2257/504 (20130101) B01D 2258/0283 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) B01J 20/2804 (20130101) B01J 20/3225 (20130101) B01J 20/28042 (20130101) B01J 20/28047 (20130101) Original (OR) Class B01J 20/28052 (20130101) B01J 20/28064 (20130101) B01J 20/28076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025108 | BENZA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DONALD BENZA (AIKEN, South Carolina); AARON WASHINGTON, II (MARTINEZ, Georgia); JONATHAN BAKER (AIKEN, South Carolina); CAMDEN A. CHATHAM (AIKEN, South Carolina); ADRIAN MISTREANU (WILMINGTON, North Carolina) |
| ABSTRACT | Additive manufacturing methods and systems are disclosed for chemical modification of a build material through at least 300 nm of the depth of each deposited layer. The depth of penetration of chemical modification is brought about through formation parameters including increased pressure, decreased humidity, formation temperatures, etc. Formed build product properties are improved as compared to those formed by traditional bulk manufacturing methods as well as to those formed by previously known additive manufacturing methods. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/869451 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/268 (20170801) B29C 64/364 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025359 | Verma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kiren E. Verma (Oak Ridge, Tennessee); Robert A. Bridges (Oak Ridge, Tennessee); Samuel C. Hollifield (Oak Ridge, Tennessee) |
| ABSTRACT | A system for decoding an unknown automotive controller area network (“CAN”) message definitions. CAN data vehicle signal mappings are typically held in secret and varied by automotive model and year. Without knowledge of the mappings, the wealth of real-time vehicle data hidden in the automotive CAN packets is uninterpretable—impeding research, after-market tuning, efficiency and performance monitoring, fault diagnosis, and privacy-related technologies. This system can ascertain the CAN signals' boundaries (start bit and length), endianness (byte ordering), signedness (binary-to-integer encoding) from raw CAN data. This allows conversion of CAN data to time series. Interpreting the translated CAN data's physical meaning and finding a linear mapping to standard units (e.g., knowing the signal is speed and scaling values to represent units of miles per hour) can be achieved for many signals by leveraging diagnostic standards to obtain real-time measurements of in-vehicle systems. The system can be integrated into lightweight hardware enabling an OBD-II plugin for real-time in-vehicle CAN decoding or run on standard computers. The system can output a standard DBC file with the signal definition information. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/372966 |
| CURRENT CPC | Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 16/0232 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/008 (20130101) G07C 5/10 (20130101) G07C 5/0808 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025748 | Arnold et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael S. Arnold (Ann Arbor, Michigan); Mark C. Hersam (Wilmette, Illinois); Samuel I. Stupp (Chicago, Illinois) |
| ABSTRACT | The present teachings provide methods for providing populations of single-walled carbon nanotubes that are substantially monodisperse in terms of diameter, electronic type, and/or chirality. Also provided are single-walled carbon nanotube populations provided thereby and articles of manufacture including such populations. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/167244 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/172 (20170801) Original (OR) Class C01B 2202/02 (20130101) C01B 2202/22 (20130101) C01B 2202/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026114 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ting Xu (Berkeley, California); Christopher A. DelRe (Berkeley, California) |
| ABSTRACT | Systems and methods for programmable degradation of a plastic deploy a plastic comprising a nanoscopic dispersion of enzymes and configured to exploit enzyme active sites and enzyme-protectant interactions to provide processive depolymerization as the primary degradation pathway with expanded substrate selectivity to effect substantially complete depolymerization without substantial microplastics formation with partial polymer degradation. |
| FILED | Sunday, September 24, 2023 |
| APPL NO | 18/473252 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/105 (20130101) Original (OR) Class C08J 2367/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/20 (20130101) C12N 9/50 (20130101) Enzymes C12Y 301/01003 (20130101) C12Y 304/21064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026126 | Krupp et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MOLECULAR REBAR DESIGN, LLC (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | August Krupp (Austin, Texas); Clive P. Bosnyak (Dripping Springs, Texas); Kurt W. Swogger (Austin, Texas); Vidal Torres (Austin, Texas); David Parker Cole (Austin, Texas) |
| ABSTRACT | The present application is directed to novel discrete carbon nanotubes with a surface modification that disperses well in elastomers and crosslinks elastomers to the surface of the discrete carbon nanotubes, or in the vicinity of the discrete carbon nanotube surface. Significant improvements in the performance of elastomeric formulations with a plurality of discrete carbon nanotubes with a surface modification and silica and/or carbon black result, for example, improved abrasion resistance while at the same time providing a reduced hysteresis effect on cyclic deformation. These improved properties are highly desired for fuel efficient and longer wear life tire formulations. |
| FILED | Friday, April 07, 2023 |
| APPL NO | 18/132299 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/174 (20170801) C01B 2202/02 (20130101) C01B 2202/06 (20130101) C01B 2202/34 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/13 (20130101) C01P 2004/64 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) C08K 9/08 (20130101) Original (OR) Class C08K 2201/004 (20130101) C08K 2201/011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026156 | Liao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Chen Liao (Westmont, Illinois); Trevor L. Dzwiniel (Carol Stream, Illinois); Kewel Liu (Aurora, Illinois) |
| ABSTRACT | Described herein are borate salts useful as additives, binders, and electrolyte salts for solid state lithium ion batteries. In particular, the borate salts of Formula (I), Formula (II) and Formula (III) as described herein: can be bound to an existing polymer to provide polymeric binders for ceramic solid state electrolytes that are themselves capable of ion transport independent of the ceramic. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/114055 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/04 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 79/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/37 (20130101) Compositions of Macromolecular Compounds C08L 85/04 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/622 (20130101) H01M 10/0525 (20130101) H01M 10/0565 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026393 | LING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chen LING (Lakewood, Colorado); Christopher W. JOHNSON (Denver, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); George Lee PEABODY, V (Oak Ridge, Tennessee); Adam Michael GUSS (Oak Ridge, Tennessee) |
| ABSTRACT | Muconic acid is a molecule that can be converted into direct replacement chemicals for incumbent petrochemicals and performance-advantaged bioproducts. Disclosed herein are Pseudomonas putida KT2440 that are engineered to convert glucose and xylose, the primary carbohydrates in lignocellulosic hydrolysates, to muconic acid using a model-guided strategy to maximize the theoretical yield. Using adaptive laboratory evolution (ALE) and metabolic engineering in a strain engineered to express the D-xylose isomerase pathway, we demonstrated that mutations in the heterologous D-xylose:H+ symporter (XylE), increased expression of a major facilitator superfamily transporter (PP_2569), and overexpression of aroB encoding the native 3-dehydroquinate synthase, enable efficient muconic acid production from glucose and xylose simultaneously. Using the rationally engineered strain, we produced 33.7 g/L muconate at 0.18 g/L/h and a 46% molar yield (92% of the maximum theoretical yield). |
| FILED | Monday, March 20, 2023 |
| APPL NO | 18/123968 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 51/36 (20130101) C07C 51/42 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/44 (20130101) Original (OR) Class Enzymes C12Y 401/01063 (20130101) C12Y 402/01118 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026499 | Luo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); Terves, Inc. (Euclid, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan Luo (Columbus, Ohio); Joshua Caris (Euclid, Ohio); Thomas Avey (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are magnesium alloys and methods of making and use thereof. For example, disclosed herein are magnesium alloys comprising: from 0 to 1.5 wt. % Zn; from 0 to 1.5 wt. % Al; less than 0.2 wt. % Ca; from 0.2 to 0.4 wt. % Ce; from 0.1 to 0.8 wt. % Mn; and the balance comprising Mg. In some examples, the magnesium alloy comprises less than 1 wt. % Zn. In some examples, the magnesium alloy comprises less than 1 wt. % Al. In some examples, the magnesium alloy exhibits substantially no incipient melting when extruded with a ram speed of from 1.00 to 10.00 ipm. In some examples, the magnesium alloy is substantially free of a Mg2Ca phase, an AlCaMg phase, an Al2Ca phase, a Ca2Mg6Zn3 phase, or a combination thereof. In some examples, the magnesium alloy is substantially free of a Mg2Ca phase. |
| FILED | Thursday, July 20, 2023 |
| APPL NO | 18/224247 |
| CURRENT CPC | Alloys C22C 1/12 (20230101) C22C 23/02 (20130101) Original (OR) Class C22C 23/04 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026528 | BERMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Dallas, Texas); UCHICAGO ARGONNE, LLC (Chicago, Illinois); THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Diana BERMAN (Dallas, Texas); Elena V. SHEVCHENKO (Chicago, Illinois); Supratik GUHA (Chicago, Illinois) |
| ABSTRACT | A method of forming an inorganic film on a surface can include depositing a polymer at a layer on a surface, swelling the polymer with a solvent to produce a swollen polymer on the surface, infiltrating the swollen polymer with a precursor, removing the swollen polymer after infiltrating the swollen polymer with the precursor, and forming a porous inorganic film on the surface based on removing the swollen polymer. |
| FILED | Saturday, July 22, 2023 |
| APPL NO | 18/357114 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/01 (20130101) C23C 16/06 (20130101) C23C 16/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026854 | Morris et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EMRGY, INC. (ATLANTA, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily Morris (Atlanta, Georgia); Thomas R. Cuthbert, III (Atlanta, Georgia); John Tuttle (Atlanta, Georgia); Retonya Dunning (Atlanta, Georgia); Michael Savoie (Atlanta, Georgia); William Clarizio (Atlanta, Georgia); Lalit Roy (Atlanta, Georgia) |
| ABSTRACT | A hydrokinetic turbine system with dynamic tuning capabilities is disclosed. Individual hydrokinetic turbine units are dynamically tuned to accommodate changes in height and flow velocity corresponding to water in a waterway. Dynamically tuning the turbine units to accommodate waterway changes optimizes power generation output. Dynamically tuning a turbine system includes raising or lowering turbine blade height, extending or retracting turbine blade length, and narrowing or widening a turbine mouth, channel, and exit through which water flows. The hydrokinetic turbines may be arranged in an array along a waterway, and each hydrokinetic turbine in the array is connected over a controls system configured to adjust turbine characteristics at each turbine unit in the array for optimizing power generation output for the waterway in which the turbine array is installed. |
| FILED | Tuesday, July 18, 2023 |
| APPL NO | 18/354450 |
| CURRENT CPC | Machines or Engines for Liquids F03B 13/08 (20130101) F03B 15/005 (20130101) F03B 15/16 (20130101) Original (OR) Class Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2220/32 (20130101) F05B 2220/706 (20130101) F05B 2270/1033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027638 | Tantawi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TibaRay, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | TibaRay, Inc. (Santa Clara, California) |
| INVENTOR(S) | Sami Tantawi (Stanford, California); Luyao Xu (Santa Clara, California); Filippos Toufexis (Redwood City, California) |
| ABSTRACT | Beam monitors, methods of use and fabrication are provided herein. Beam monitors can include a rounded beam cavity with one or more waveguide connected thereto, from which a signal can be used to determine one or more beam characteristics. Such monitors can include a beam intensity monitor that includes a cylindrical beam cavity with a rectangular waveguide extending from a periphery, from which beam intensity can be determined. An advanced beam monitor can include a multi-moded beam cavity having multiple waveguides connected at distinct locations, each corresponding to a differing excitation mode. Such monitor can include an elliptical beam cavity and five waveguides connected thereto, signals from which can be used to determine beam charge, beam position and beam size in both the x-direction and y-directions. Beam monitors can be stand-alone devices or integrated within linear accelerators. Accelerators can include off-axis beam monitor coupling ports and on-axis tuning features. |
| FILED | Thursday, May 25, 2023 |
| APPL NO | 18/202226 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2914 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 9/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027978 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Xingyong Song (Cypress, Texas); Sencheng Yu (College Station, Texas); Zongxuan Sun (Plymouth, Minnesota) |
| ABSTRACT | A computer-implemented method for predicting external resistive forces encountered by an industrial machine includes (a) predicting by a first model a resistive force applied to an industrial machine from an external material using previously collected sensor data, (b) predicting by a second model that is different from the first model an error of the resistive force predicted by the first model using the previously collected sensor data and the resistive force predicted by the first model, and (c) determining a corrected prediction of the resistive force by combining the resistive force predicted by the first model with the error predicted by the second model. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/223914 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) G05B 13/048 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028206 | Baronne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Baronne (Allen, Texas); Dean E. Walker (Allen, Texas); Bryan Hornung (Plano, Texas) |
| ABSTRACT | Various examples are directed to systems and methods for executing a transaction between hardware compute elements of a computing system. A first hardware compute element may send a first write request to a second hardware compute element via a network structure. The first write request may comprise first source identifier data describing the first hardware compute element and first payload data describing a processing task requested by the first hardware compute element. The network structure may store first write request state data describing the first write request. Before the processing task is completed, the second hardware compute element may send a first write confirm message. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/813800 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0611 (20130101) Original (OR) Class G06F 3/0659 (20130101) G06F 3/0673 (20130101) G06F 12/0802 (20130101) G06F 2212/1024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028390 | Baronne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Baronne (Allen, Texas); Michael Keith Dugan (Richardson, Texas); Bryan Hornung (Plano, Texas) |
| ABSTRACT | Various examples are directed to an arrangement comprising a first hardware compute element and a hardware balancer element. The first hardware compute element may send a first request message to a hardware balancer element. The first request message may describe a processing task. The hardware balancer element may send a second request message towards a second hardware compute element for executing the processing task and send to the first compute element a first reply message in reply to the first request message. After sending the first reply message, the hardware balancer element may receive a first completion request message indicating that the processing task is assigned and send, to the first hardware computing element, a second completion request message, the second completion request message indicating that the processing task is assigned. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/813763 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/505 (20130101) G06F 9/4881 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028526 | Baronne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Baronne (Allen, Texas); Tony M. Brewer (Plano, Texas) |
| ABSTRACT | Various examples are directed to systems and methods for requesting an atomic operation. A first hardware compute element may send a first request via a network structure, where the first request comprises an atomic opcode indicating an atomic operation to be performed by a second hardware compute element. The network structure may provide an address bus from the first hardware compute element for providing the atomic opcode to the second hardware compute element. The second hardware compute element may execute the atomic operation and send confirmation data indicating completion of the atomic operation. The network structure may provide a second bus from the second hardware compute element and the first hardware compute element. The second bus may be for providing the confirmation data from the second hardware compute element to the first hardware compute element. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/813780 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/1668 (20130101) Original (OR) Class G06F 13/4027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029093 | Parvania et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Masood Parvania (Salt Lake City, Utah); Mohammad Mehdi Hosseini (Salt Lake City, Utah); Luis Fernando Rodriguez Garcia (Salt Lake City, Utah); Avishan Bagherinezhad (Salt Lake City, Utah) |
| ABSTRACT | A computer system for real-time coordinated operation of power distribution systems and electric vehicles identifies a set of integrated hybrid resources (IHRs), wherein each IHR within the set of IHRs comprises one or more of: energy storage (ES) systems, solar generating units, electric vehicles (EVs), and/or inflexible loads. The computer system executes, at an IHR selected from the set of IHRs, a deep deterministic policy gradient (DDPG) algorithm, the DDPG algorithm utilizing a critic deep neural network and an actor deep neural network. The critic deep neural network estimates a Q-value of an action for a given state, and the actor deep neural network estimates a best action for the given state. Based upon an output of the DDPG algorithm, the computer system generates a charging schedule for the ES systems and the EVs within the IHR. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/078267 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0206 (20130101) Original (OR) Class G06Q 50/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029579 | Greenwood et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Scott Greenwood (Oak Ridge, Tennessee); Michael B. R. Smith (Oak Ridge, Tennessee); Nick Thompson (Oak Ridge, Tennessee); Noel B. Nelson (Oak Ridge, Tennessee); Douglas E. Peplow (Oak Ridge, Tennessee) |
| ABSTRACT | Interactive augmented-reality technologies track simulated-radiation exposure of a user moving through a physical scene. The simulated-radiation exposure tracking is performed using radiation voxels associated with a simulated radiation field caused as if a radioactive source of a particular type was emitting radiation from a predetermined location of the scene. Each radiation voxel is indicative of a respective level of the simulated radiation field at the voxel's scene location. |
| FILED | Friday, April 14, 2023 |
| APPL NO | 18/134649 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/017 (20130101) G06F 3/167 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 9/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029911 | Lukin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mikhail D. Lukin (Cambridge, Massachusetts); Vladan Vuletic (Cambridge, Massachusetts); Markus Greiner (Cambridge, Massachusetts); Ruben Verresen (Cambridge, Massachusetts); Ashvin Vishwanath (Cambridge, Massachusetts); Alexander Keesling Contreras (Cambridge, Massachusetts); Harry Jay Levine (Cambridge, Massachusetts); Giulia Semeghini (Cambridge, Massachusetts); Tout Taotao Wang (Cambridge, Massachusetts); Ahmed Omran (Cambridge, Massachusetts); Dolev Bluvstein (Cambridge, Massachusetts); Sepehr Ebadi (Cambridge, Massachusetts) |
| ABSTRACT | Topological qubits are provided in a quantum spin liquid. In various embodiments, a device is provided comprising a two-dimensional array of particles, each particle disposed at a vertex of a ruby lattice having a parameter ρ greater than |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/320708 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) G06N 10/70 (20220101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030356 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sang-Woo Han (University Park, Pennsylvania); Jianan Song (University Park, Pennsylvania); Rongming Chu (University Park, Pennsylvania); Mansura Sadek (University Park, Pennsylvania) |
| ABSTRACT | Embodiments relate a super-heterojunction structure. A n-type modulation doping with barrier layer induces a two-dimensional electron gas (2DEG) channel and allows for vertically stacked channels without risk of reaching critical thickness limited by the strain in epitaxy. The n-type modulation doped layer is adjacent the at least one p-type layer to generate a charge balanced super-heterojunction region. A p-type ohmic contact ensures that the processes of depleting and accumulating of electrons and holes in the structure are fast enough for practical switching operation. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 18/247753 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/0634 (20130101) H01L 29/872 (20130101) Original (OR) Class H01L 29/7788 (20130101) H01L 29/7806 (20130101) H01L 29/66212 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030400 | Archer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lynden A. Archer (Ithaca, New York); Jingxu Zheng (Shenzhen, China PRC) |
| ABSTRACT | Methods of making a textured metal or a textured metal layer, anodes, and devices. In various examples, a method comprises rolling a metal; and folding the rolled metal. In various examples, the rolling and folding are repeated a desired number of times. In various examples, the rolling(s) result(s) in severe plastic deformation (SPD) of the metal, anisotropic deformation(s), or alignment of the metal, or any combination thereof. In various examples, the metal comprises potassium, sodium, lithium, zinc, magnesium, aluminum, calcium, or the like, or any combination thereof. In various examples, an anode comprises a textured metal. In various examples, the textured metal epitaxially templates deposition of the reduced form of metal-ions of a metal ion-conducting electrochemical device. In various examples, a device, such as, for example, a battery (e.g., an ion-conducting battery), a supercapacitor, a fuel cell, an electrolyzer, or an electrolytic cell, comprises one or more of the anode(s). |
| FILED | Thursday, July 20, 2023 |
| APPL NO | 18/356139 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/0435 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030471 | Evans |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ESS TECH, INC. (Wilsonville, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig E. Evans (West Linn, Oregon) |
| ABSTRACT | A rebalancing reactor for a redox flow battery system may include a first side through which hydrogen gas is flowed, a second side through which electrolyte from the redox flow battery system is flowed, and a porous layer separating and fluidly coupled to the first side and the second side, wherein, the hydrogen gas and the electrolyte are fluidly contacted at a surface of the porous layer, and a pressure drop across the second side is less than a pressure drop across the porous layer. In this way, rebalancing of electrolyte charges in a redox flow battery system may be performed with increased efficiency and cost effectiveness as compared to conventional rebalancing reactors. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/480426 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) H01M 8/0687 (20130101) Original (OR) Class H01M 8/2455 (20130101) H01M 8/04186 (20130101) H01M 8/04276 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030501 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (ldaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin Li (ldaho Falls, Idaho); Corey M. Efaw (Boise, Idaho); Eric J. Dufek (Ammon, Idaho) |
| ABSTRACT | An electrochemical cell is disclosed and comprises an electrolyte between a cathode and an anode and a protective layer between the anode and the electrolyte. The protective layer comprises a porous layer over the anode and a dense layer over the porous layer, each of the porous layer and the dense layer comprising an inorganic compound, an organic compound, or an inorganic-organic composite. Additional electrochemical cells are disclosed. Also disclosed is a method of forming an electrochemical cell. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 18/247577 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/045 (20130101) H01M 4/134 (20130101) H01M 4/382 (20130101) H01M 4/1395 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030583 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Faraday Technology, Inc. (Englewood, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danny Xin Liu (Tipp City, Ohio); Holly Garich (Fairborn, Ohio); Timothy D. Hall (Englewood, Ohio); Earl Jennings Taylor (Bonita Springs, Florida) |
| ABSTRACT | A method of manufacturing a corrugated copper microwave waveguide comprising placing a mandrel with external corrugations in an electrolyte bath substantially devoid of brighteners, accelerators, or levelers and including copper ions, sulfuric acid, chloride, and polyethylene glycol. The mandrel is placed proximate a copper anode in the bath. One or more waveforms are applied to the mandrel and anode to control electrodeposition distribution of copper to the mandrel rather than controlling the electrolyte bath chemistry. The mandrel and the resulting electroformed waveguide are removed from the electrolyte bath and the mandrel is excised (e.g., dissolved) resulting in a microwave waveguide with internal corrugations. Substantially devoid of additives (brighteners, accelerators, and/or levelers) generally means not having to repeatedly meter in additives during the electroforming process. |
| FILED | Monday, July 17, 2023 |
| APPL NO | 18/353265 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/02 (20130101) C25D 21/12 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 11/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030716 | Gong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GE Grid GmbH (Frankfurt Am Main, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maozhong Gong (Niskayuna, New York); Hanchao Liu (Niskayuna, New York); Philip Joseph Hart (Burnt Hills, New York); Zhe Chen (Schenectady, New York) |
| ABSTRACT | A renewable power system is provided. The renewable power system includes a plurality of power generating devices and a plurality of power converters. Each power converter of the plurality of power converters is electrically coupled to at least one power generating device of the plurality of power generating devices and a load. The renewable power system further includes a plurality of controllers. Each of the plurality of controllers includes a processor coupled in communication with at least one power converter of the plurality of power converters. The processor is configured to detect a load power of the load, determine an available power of the plurality of power generating devices, and, in response to the load exceeding the available power of the plurality of power generating devices, adjust at least one parameter of the at least one power converter. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/870472 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 9/02 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/32 (20130101) H02J 3/381 (20130101) Original (OR) Class H02J 3/388 (20200101) H02J 2300/24 (20200101) H02J 2300/28 (20200101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/537 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030766 | Alahyari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abbas A. Alahyari (Glastonbury, Connecticut); Parag M. Kshirsagar (South Windsor, Connecticut); Beata I. Wawrzyniak (South Windsor, Connecticut) |
| ABSTRACT | An electric machine includes a rotor located at and rotatable about a central axis and a stator positioned proximate to the rotor and defining a radial machine gap between the rotor and the stator. A cold plate is positioned proximate to the rotor. The cold plate is rotationally stationary relative to the central axis and is spaced apart from the rotor to define a cold plate gap between the cold plate and the rotor. The cold plate includes one or more coolant pathways therein such that thermal energy from the rotor is transferred to a flow of coolant circulated through the one or more coolant pathways. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871286 |
| CURRENT CPC | Dynamo-electric Machines H02K 1/32 (20130101) Original (OR) Class H02K 9/197 (20130101) H02K 9/225 (20210101) H02K 2201/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030916 | Turner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NVIDIA Corp. (Santa Clara, California) |
| ASSIGNEE(S) | NVIDIA Corp. (Santa Clara, California) |
| INVENTOR(S) | Walker Joseph Turner (Jacksonville, Florida); John Poulton (Chapel Hill, North Carolina); Sanquan Song (Mountain View, California) |
| ABSTRACT | A level-shifting circuits utilizing storage cells for shifting signals low-to-high or high-to-low include control drivers with moving supply voltages. The moving supply voltages may power positive or negative supply terminals of the control drivers. The control drivers drive gates of common-source configured devices coupled to storage nodes of the storage cell. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/932052 |
| CURRENT CPC | Pulse Technique H03K 3/356165 (20130101) H03K 19/0013 (20130101) H03K 19/018521 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030917 | Turner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NVIDIA Corp. (Santa Clara, California) |
| ASSIGNEE(S) | NVIDIA Corp. (Santa Clara, California) |
| INVENTOR(S) | Walker Joseph Turner (Jacksonville, Florida); John Poulton (Chapel Hill, North Carolina); Sanquan Song (Mountain View, California) |
| ABSTRACT | Stacked voltage domain level shifting circuits for shifting signals low-to-high or high-to-low include a storage cell and control drivers powered by a mid-range supply rail of the stacked voltage domain level shifting circuit, wherein the control drivers are coupled to drive common-source configured devices coupled to storage nodes of the storage cell. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/932075 |
| CURRENT CPC | Pulse Technique H03K 3/356165 (20130101) H03K 19/0013 (20130101) H03K 19/018521 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030918 | Turner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NVIDIA Corp. (Santa Clara, California) |
| ASSIGNEE(S) | NVIDIA Corp. (Santa Clara, California) |
| INVENTOR(S) | Walker Joseph Turner (Jacksonville, Florida); John Poulton (Chapel Hill, North Carolina); Sanquan Song (Mountain View, California) |
| ABSTRACT | Stacked voltage domain level shifting circuits for shifting signals low-to-high or high-to-low include a storage cell powered by a mid-range supply rail of the stacked voltage domain level shifting circuit, and control drivers powered by moving supply voltages generated by the storage cell, wherein the control drivers coupled to drive gates of common-source configured devices coupled to storage nodes of the storage cell. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/932091 |
| CURRENT CPC | Pulse Technique H03K 3/356165 (20130101) H03K 19/0013 (20130101) H03K 19/018521 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240023846 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Weijian Yang (Redwood, California); Shing-Jiuan Liu (Davis, California); Soheil Ghiasi (Davis, California) |
| ABSTRACT | This disclosure provides transabdominal fetal oximetry (TFO) that uses frequency-modulated continuous-wave (FMCW) time-domain near-infrared spectroscopy to measure time-resolved reflectance values of light signals collected from a maternal-fetal multilayer tissue structure. In various embodiments, the disclosed FMCW time-domain near-infrared spectroscopy is configured to function as an optical interferometer that uses two frequency-swept laser sources of different center wavelengths λ1 and λ2 as probe lights to detect optical property in vascular tissues of the maternal-fetal multilayer tissue structure. The FMCW near-infrared spectroscopy is configured to collect light signals returned from the multilayer structure and generate a time-resolved reflectance curve based on the collected light signals. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 18/249714 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1464 (20130101) Original (OR) Class A61B 5/7203 (20130101) A61B 5/7257 (20130101) A61B 5/7267 (20130101) A61B 5/14552 (20130101) A61B 2562/0233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240023882 | Rogers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Rogers (Wilmette, Illinois); Anthony R. Banks (Evanston, Illinois); Surabhi Rao Madhvapathy (Evanston, Illinois); Heling Wang (Evanston, Illinois); Yonggang Huang (Evanston, Illinois); Shuai Xu (Chicago, Illinois) |
| ABSTRACT | This invention relates to a soft, battery-free, flexible, non-invasive, reusable hydration sensor adherable to even small-areas and curvilinear surfaces of a body. The hydration sensor measures volumetric water content in skin as a function of depth, and wirelessly transmits data to a portable smart device. The hydration sensor includes a top layer for thermal, chemical and mechanical isolation of the hydration sensor from an environment; a bottom layer operably placed on a target area of interest on the skin; and a flexible printed circuit board (f-PCB) disposed between the top layer and the bottom layer. The f-PCB contains electronics for sensing and wireless communication. The bottom layer operably serves as a direct interface between the f-PCB and the skin and comprises a flexible adhesive for attaching the hydration sensor to the skin. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 18/031389 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/002 (20130101) A61B 5/443 (20130101) Original (OR) Class A61B 5/4875 (20130101) A61B 5/6832 (20130101) A61B 5/14521 (20130101) A61B 2562/164 (20130101) A61B 2562/166 (20130101) A61B 2562/0271 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024089 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Longhai WANG (Ithaca, New York); Alexander ERNST (Ithaca, New York); Minglin MA (Ithaca, New York); James FLANDERS (Ithaca, New York) |
| ABSTRACT | The present disclosure is directed to devices and systems for oxygenating encapsulated cells. The disclosure further relates to individual components of these devices and systems and methods of using the devices and systems to deliver a therapeutic agent to a subject in need thereof. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 18/256441 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/022 (20130101) Original (OR) Class A61F 2002/0081 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/18 (20130101) A61L 27/025 (20130101) A61L 27/38 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024113 | Torbati et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Impressio Inc. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amir H. Torbati (Westminster, Colorado); Lyssa A. Bell (Littleton, Colorado); Lillian S. Chatham (Lakewood, Colorado); Josh Ray (Dallas, Texas); Rajib K. Shaha (Hillsboro, Oregon); Aura Penalosa (Denver, Colorado); Ross H. Volpe (San Diego, California); Richard M. Wojcik (Denver, Colorado); Christopher M. Yakacki (Denver, Colorado); Risheng Zhou (Denver, Colorado) |
| ABSTRACT | A device for a metatarsophalangeal (MTP) joint includes a body with a stem and a head. The stem may be hollow and include a plurality of perforations about its length to improve osseointegration. The head may include one or more perforations and/or one or more islands. The one or more perforations and one or more islands are configured to promote bonding the body and liquid-crystalline elastomer (LCE) that is applied to the head. The device may be inserted into bone to form an MTP joint replacement. |
| FILED | Wednesday, June 07, 2023 |
| APPL NO | 18/206821 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/30756 (20130101) Original (OR) Class A61F 2002/4233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024239 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW JERSEY INSTITUTE OF TECHNOLOGY (Newark, New Jersey) |
| ASSIGNEE(S) | NEW JERSEY INSTITUTE OF TECHNOLOGY (Newark, New Jersey) |
| INVENTOR(S) | Xiaoyang Xu (Livingston, New Jersey); Zhongyu Li (Harrison, New Jersey) |
| ABSTRACT | Ionizable cationic lipid compounds have an amine moiety from amino alcohols and a lipid moiety from a lipid synthesized via esterification. The ionizable cationic lipid compounds which comprise an amino alcohol mediated ionizable cationic lipid compound are useful for in vivo or in vitro delivery of one or more nucleic acid agents including DNA, siRNA, a microRNA, an mRNA, a RNAi, and a plasmid. |
| FILED | Monday, July 17, 2023 |
| APPL NO | 18/222839 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 9/1277 (20130101) A61K 31/711 (20130101) A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 47/22 (20130101) A61K 48/0033 (20130101) A61K 48/0091 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6436 (20130101) C12P 17/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024241 | Dave et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Rajesh N. Dave (Princeton, New Jersey); Sangah Kim (Newark, New Jersey); Zhixing Lin (Newark, New Jersey) |
| ABSTRACT | High(greater than 30%) and/or low(less than 10%) loaded multiple API powdered/nanoparticle were tabulated with increased flowability and physical properties. Properties include blend flowability and uniformity, bulk packing density, compactability, tensile strength, and dissolution. Blending is done through solventless dry mechanical coating of at least one minority API component defined as the API component with the least weight per volume surface coated with nano-sized powders in lesser amounts by wt % of the blend, and preferably less than 10% dry coated of the minority API. An excipient may be dry coated in the lesser amount wherein the excipient is a minority component. Both minority excipient and minority API may be dry coated. Using dry coating instead of dry granulation and/or wet granulation techniques in producing tablets saves manufacturing steps, costs, and produces higher quality tablets with surprisingly higher properties than expected for low flowability solid powdered ingredients. |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/221143 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/143 (20130101) Original (OR) Class A61K 9/1682 (20130101) A61K 31/192 (20130101) A61K 45/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024364 | Chick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CellDrop Biosciences, Inc. (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wallace Chick (Greenwood Village, Colorado); Benjamin Noren (Laramie, Wyoming) |
| ABSTRACT | A composition for tendon and ligament regeneration includes a biologically compatible hydrogel suspension having spherical droplets. The spherical droplets have a diameter of about 100 μm to about 300 μm and a plurality of cells. The cells include marrow-derived mesenchymal stem cells (MSCs) with an average viability of about 90% or greater and cells that retain their stemness. A method for tendon and ligament regeneration includes forming the composition, purifying the composition, retrieving the composition, and administering the composition via injection into an injury site of injured tissue. |
| FILED | Tuesday, July 18, 2023 |
| APPL NO | 18/354636 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 47/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024452 | Steinmetz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Amy M. Wen (Cleveland, Ohio); Steven Fiering (Hanover, New Hampshire); Patrick H. Lizotte (Hanover, New Hampshire) |
| ABSTRACT | A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle. |
| FILED | Tuesday, August 22, 2023 |
| APPL NO | 18/236676 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024537 | BONASSAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lawrence J. BONASSAR (Ithaca, New York); Roger HARTL (New York, New York); Robert D. BOWLES (Ithaca, New York); Harry H. GEBHARD (Tuebingen, Germany) |
| ABSTRACT | The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/105204 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/442 (20130101) A61F 2002/444 (20130101) A61F 2002/445 (20130101) A61F 2002/4435 (20130101) A61F 2002/4445 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/32 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/22 (20130101) A61L 27/24 (20130101) A61L 27/44 (20130101) A61L 27/52 (20130101) A61L 27/3658 (20130101) Original (OR) Class A61L 27/3691 (20130101) A61L 27/3817 (20130101) A61L 27/3856 (20130101) A61L 27/3886 (20130101) A61L 2430/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025748 | Arnold et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael S. Arnold (Ann Arbor, Michigan); Mark C. Hersam (Wilmette, Illinois); Samuel I. Stupp (Chicago, Illinois) |
| ABSTRACT | The present teachings provide methods for providing populations of single-walled carbon nanotubes that are substantially monodisperse in terms of diameter, electronic type, and/or chirality. Also provided are single-walled carbon nanotube populations provided thereby and articles of manufacture including such populations. |
| FILED | Friday, February 10, 2023 |
| APPL NO | 18/167244 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/172 (20170801) Original (OR) Class C01B 2202/02 (20130101) C01B 2202/22 (20130101) C01B 2202/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240025925 | THOMAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andy A. THOMAS (College Station, Texas); Michael P. CROCKETT (College Station, Texas); Lupita S. AGUIRRE (College Station, Texas); Leonel B. JIMENEZ (College Station, Texas); Han-Hsiang HSU (College Station, Texas) |
| ABSTRACT | Systems and methods for formation of highly reactive alkali dendrites are provided. For example, in some embodiments alkali metals are dissolved in ammonia to form metal electrides after which the ammonia is removed via vacuum to reveal highly activated metal surfaces in the form of crystalline alkali dendrites. The alkali dendrites can mimic powders but have the advantage of being freshly prepared from inexpensive and readily available metal sources. These uniquely activated metals exhibit enhanced reactivity comparatively to similar off the shelf sources of the corresponding metals. For example, the dendrites can have about 100 times greater surface area than conventional metal sources and/or be about 19 times more reactive than powders that serve as the industry standard for the preparation of organometallic compounds. After surface activation, these metals can be used to prepare various organometallic reagents. |
| FILED | Thursday, July 20, 2023 |
| APPL NO | 18/224207 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/16 (20130101) Acyclic or Carbocyclic Compounds C07C 1/328 (20130101) C07C 29/70 (20130101) C07C 45/44 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/02 (20130101) Original (OR) Class C07F 5/027 (20130101) Alloys C22C 1/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026261 | HUH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongeun HUH (Villanova, Pennsylvania); Sunghee Estelle PARK (Philadelphia, Pennsylvania) |
| ABSTRACT | The disclosed subject matter provides techniques for culturing organoids or cells. A device for culturing organoids can include an access port configured to receive a solution, a loading chamber, wherein the access port is located in the loading chamber, and a plurality of culture chambers, wherein the culture chambers are radiated from the loading chamber so that the solution injected into the loading chamber through the access port is distributed into the plurality of culture chambers, wherein the plurality of culture chambers are open to an external environment and comprises a protruding edge at an opening of the plurality of culture chambers. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 18/255398 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/12 (20130101) C12M 23/22 (20130101) C12M 23/34 (20130101) C12M 25/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026267 | Mao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leidong Mao (Watkinsville, Georgia); Yang Liu (Albany, California); Wujun Zhao (Waunakee, Wisconsin) |
| ABSTRACT | The present disclosure provides for microfluidic devices, systems, kits, and methods of using multi-stage microfluidic devices are provided for high throughput sorting, separation/enrichment of target rare cells from a sample, and can additionally provide for characterization/phenotyping of circulating tumor cells (CTCs) and other unlabeled rare cells in a biological sample such as blood, where the rare cells do not need to be labeled. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/224717 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/16 (20130101) C12M 35/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026289 | HUTCHENS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shelby B. HUTCHENS (Champaign, Illinois); Amrita KATARUKA (Mountain View, California) |
| ABSTRACT | An osmotically-active closed-cell composite comprises a closed-cell structure including fluid-filled cells separated by cell walls, where the fluid-filled cells comprise water and a solute, and the cell walls comprise a polymer permeable to water and impermeable to the solute. The closed-cell structure is configured to undergo osmotically-induced swelling during exposure to an aqueous environment having a different chemical potential from the fluid-filled cells. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/224662 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026315 | Barnes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DNA POLYMERASE TECHNOLOGY, INC. (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne M. Barnes (University City, Missouri); Milko B. Kermekchiev (St. Louis, Missouri); Zhian Zhang (Ballwin, Missouri) |
| ABSTRACT | Provided are mutant polymerases having DNA polymerase activity and reverse transcriptase activity or strand displacement activity, along with target nucleic acid amplification methods employing such mutant polymerases. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/476104 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) Original (OR) Class C12N 9/1276 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6846 (20130101) C12Q 2521/101 (20130101) C12Q 2531/101 (20130101) C12Q 2531/119 (20130101) Enzymes C12Y 207/07007 (20130101) C12Y 207/07049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240026334 — DNA-COLLAGEN COMPLEXES AND MAGNETOELECTRIC JANUS MATERIALS FOR BIOMEDICAL APPLICATIONS
| US 20240026334 | ALLEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Josephine ALLEN (Gainesville, Florida); Jennifer S. ANDREW (Gainesville, Florida); Noah D. FERSON (Gainesville, Florida); Bryan D. JAMES (Gainesville, Florida) |
| ABSTRACT | Disclosed herein are compositions comprising magnetoelectric composite materials and collagen, along with uses and kits thereof. Described herein is the use of DNA aptamer assemblies of varying DNA length, structure, and sequence to both bind to collagen and other proteins, to then act as a biocompatible, degradable, reversible, or permanent 3D crosslinkers between proteins, and to service as a biologically functional material when using the appropriate aptamer sequence. Therefore, disclosed herein are compositions comprising collagen fibers crosslinked with DNA aptamers. Also disclosed are devices and implants made from or coated with collagen fibers crosslinked with DNA aptamers. Also disclosed are methods of making collagen fibers. Also disclosed are kits for producing collagen fibers. Also disclosed herein are compositions DNA aptamers in a collagen fiber matrix that stabilizes the DNA aptamer. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 18/044094 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 13/00 (20130101) Original (OR) Class C12N 15/115 (20130101) C12N 2310/16 (20130101) C12N 2310/3513 (20130101) C12N 2529/00 (20130101) C12N 2533/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026408 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); The Regents of the University of Colorado (Denver, Colorado); The Board of Regents of the University of Oklahoma (Norman, Oklahoma); Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daeyeon Lee (Wynnewood, Pennsylvania); Masoud Soroush (Robbinsville, New Jersey); Joel Kaar (Lafayette, Colorado); Dimitrios Papavassiliou (Norman, Oklahoma); Kathleen J Stebe (Penn Valley, Pennsylvania) |
| ABSTRACT | Systems, comprising: an aqueous medium, the aqueous medium having an amount of DNA disposed therein, the aqueous medium having one or more RNA polymerases disposed therein; and a non-aqueous medium. Methods, the methods comprising operating a system according to the present disclosure, so as to give rise to an RNA product disposed in the non-aqueous medium. Methods, comprising: with an RNA polymerase in an aqueous medium, effecting synthesis of an RNA product from template DNA, and selectively transferring the RNA product to a non-aqueous medium. |
| FILED | Thursday, July 20, 2023 |
| APPL NO | 18/355437 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1247 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026411 | Jewett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Jessica Carol Stark (Evanston, Illinois); Jasmine Hershewe (Evanston, Illinois) |
| ABSTRACT | Disclosed are methods, systems, components, and compositions for cell-free synthesis of proteins and glycoproteins. The methods, systems, components, and compositions may be utilized for incorporating non-standard amino acids (nsAAs) into cell-free synthesized proteins and glycosylating or otherwise modifying the cell-free synthesized proteins in vitro. The nsAAs of the cell-free synthesized protein may be modified via glycosylation or other modification. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/343633 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/16 (20130101) C12N 9/0051 (20130101) C12N 9/88 (20130101) C12N 9/93 (20130101) C12N 9/1051 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class Enzymes C12Y 108/01007 (20130101) C12Y 301/21001 (20130101) C12Y 402/01047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026528 | BERMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Dallas, Texas); UCHICAGO ARGONNE, LLC (Chicago, Illinois); THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Diana BERMAN (Dallas, Texas); Elena V. SHEVCHENKO (Chicago, Illinois); Supratik GUHA (Chicago, Illinois) |
| ABSTRACT | A method of forming an inorganic film on a surface can include depositing a polymer at a layer on a surface, swelling the polymer with a solvent to produce a swollen polymer on the surface, infiltrating the swollen polymer with a precursor, removing the swollen polymer after infiltrating the swollen polymer with the precursor, and forming a porous inorganic film on the surface based on removing the swollen polymer. |
| FILED | Saturday, July 22, 2023 |
| APPL NO | 18/357114 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/01 (20130101) C23C 16/06 (20130101) C23C 16/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027265 | LIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HI-Spectral, LLC (Kula, Hawaii) |
| ASSIGNEE(S) | HI-Spectral, LLC (Kula, Hawaii) |
| INVENTOR(S) | Haosheng LIN (Kula, Hawaii); Morgan B. BONNET (Honolulu, Hawaii) |
| ABSTRACT | A compact structure for snapshot hyperspectral imaging may include an image slicer, an integral field unit, an integral field spectrograph, and multiplexed integral field spectrograph. The image slicer includes a first section having a first plurality of mirrors, each mirror of the first plurality of mirrors having a predetermined tilt in a longitudinal direction, a second section having a second plurality of mirrors, each mirror of the second plurality of mirrors having a predetermined tilt in the longitudinal direction, and a ridge extending laterally between the first section and the second, the first section being at a first angle relative to the ridge and the second section being at a second angle opposite to the first angle relative to the ridge. The integral field unit source includes a four mirror design including an image slicer. The integral field spectrograph includes an array of spectrographs and an image slicer. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/224594 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/021 (20130101) Original (OR) Class G01J 3/2803 (20130101) G01J 3/2823 (20130101) G01J 2003/2826 (20130101) Optical Elements, Systems, or Apparatus G02B 17/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027554 | Grayson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew A. Grayson (Evanston, Illinois); Jiajun Luo (Jersey City, New Jersey); Can Aygen (Chicago, Illinois) |
| ABSTRACT | A system to improve a product based on a relaxation response includes a memory configured to store relaxation response data of a sample. The relaxation response data includes time data and amplitude data. A processor is operatively coupled to the memory and configured to convert the relaxation response data to linear-amplitude versus log-time data. The processor also performs a least-squares fit of the converted relaxation response data to a heavy-tail function to determine one or more fit parameter values. The processor also updates a design for the sample based at least in part on the one or more fit parameter values. |
| FILED | Thursday, July 20, 2023 |
| APPL NO | 18/224292 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/448 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027655 | Bifano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Thomas Bifano (Mansfield, Massachusetts); Jerome Mertz (Newton, Massachusetts); Marshall Ma (Watertown, Massachusetts); Devin Beaulieu (Brookline, Massachusetts) |
| ABSTRACT | An exemplary imaging system is provided. The imaging system includes a light source configured to illuminate a plurality of spatially separated regions of a material structure producing a first illumination. A lens produces an image of the spatially separated regions. A lens array magnifies the spatially separated regions of the image. The lens array produces a mosaic image comprised of magnified subimages of each region spatially separated region. A camera sensor to record the image. |
| FILED | Tuesday, July 18, 2023 |
| APPL NO | 18/223289 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 13/22 (20130101) Image Data Processing or Generation, in General G06T 3/4038 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/141 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028106 | ELOR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AVIV ELOR (WALNUT CREEK, California); MICHAEL ORA POWELL (CAMPBELL, California); ASH SEYMOUR ROBBINS (SANTA CRUZ, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | AVIV ELOR (WALNUT CREEK, California); MICHAEL ORA POWELL (CAMPBELL, California); ASH SEYMOUR ROBBINS (SANTA CRUZ, California) |
| ABSTRACT | A system and method for utilizing virtual reality technology to provide and improve physical therapy care. Virtual reality devices may be utilized to facilitate telehealth visits in a three-dimensional medium where a digital avatar moves in accordance with the movement of a patient wearing a virtual reality device. Virtual reality devices may be used to provide and monitor exercises prescribed for a physical therapy patient. Virtual reality devices may be used to record, model, and analyze motion patterns of a physical therapy patient to assess relevant physical capability such as balance or motor control. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868743 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 13/40 (20130101) G06T 19/006 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029698 | Guo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuning Guo (Boulder, Colorado); Massimo Ruzzene (Boulder, Colorado); Matheus Rosa (Boulder, Colorado) |
| ABSTRACT | An acoustic device includes a three-dimensional phononic crystal having cubic symmetry. The phononic crystal includes a first region filled with a first material and a second region filled with a solid material that is different from the first material. The second region is the solid complement of the first region. A boundary between the first and second regions is shaped as a single gyroid surface that has constant mean curvature and is not pinched off. The volume of the second region is greater than or equal to that of the first region. The first material may be a gas, such as air, or a fluid. The phononic crystal supports topological surface states, has a band structure with at least one degenerate point protected by nonsymmorphic symmetry, and exhibits negative refraction where two of its external surfaces meet. |
| FILED | Monday, July 24, 2023 |
| APPL NO | 18/225224 |
| CURRENT CPC | Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/30 (20130101) G10K 11/162 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240029780 — EFFICIENT MULLER C-ELEMENT IMPLEMENTATION FOR HIGH BIT-WIDTH ASYNCHRONOUS APPLICATIONS
| US 20240029780 | Emmert |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | John Martin Emmert (Dayton, Ohio) |
| ABSTRACT | A system comprises an nMOS active resistor, nMOS transistors, a pMOS active resistor, and pMOS transistors, wherein a subset of the nMOS transistors a subset of the pMOS transistors are coupled to each other, respectively, according to a parallel OR configuration, a source terminal of the nMOS active resistor is coupled to respective drain terminals of the nMOS transistors, and a source terminal of the pMOS active resistor is coupled to respective drain terminals of the pMOS transistors. The transistor level delay based circuit further includes a write subcircuit component includes one of the nMOS transistors coupled to at least one of the pMOS transistors, wherein the write subcircuit is controlled by reverse logic signals, and a gate component includes an additional subset of the plurality of nMOS transistors coupled to an additional subset of the pMOS transistors, the gate component corresponding to a semistatic cross coupled inverter circuit. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 18/265593 |
| CURRENT CPC | Static Stores G11C 11/4076 (20130101) Original (OR) Class G11C 11/4091 (20130101) G11C 11/4096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029911 | Lukin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mikhail D. Lukin (Cambridge, Massachusetts); Vladan Vuletic (Cambridge, Massachusetts); Markus Greiner (Cambridge, Massachusetts); Ruben Verresen (Cambridge, Massachusetts); Ashvin Vishwanath (Cambridge, Massachusetts); Alexander Keesling Contreras (Cambridge, Massachusetts); Harry Jay Levine (Cambridge, Massachusetts); Giulia Semeghini (Cambridge, Massachusetts); Tout Taotao Wang (Cambridge, Massachusetts); Ahmed Omran (Cambridge, Massachusetts); Dolev Bluvstein (Cambridge, Massachusetts); Sepehr Ebadi (Cambridge, Massachusetts) |
| ABSTRACT | Topological qubits are provided in a quantum spin liquid. In various embodiments, a device is provided comprising a two-dimensional array of particles, each particle disposed at a vertex of a ruby lattice having a parameter ρ greater than |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/320708 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) G06N 10/70 (20220101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029912 | Ndukaife |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justus C. Ndukaife (Nashville, Tennessee) |
| ABSTRACT | A nanotweezer and method of trapping and dynamic manipulation thereby are provided. The nanotweezer comprises a first metastructure including a first substrate, a first electrode, and a plurality of plasmonic nanostructures arranged in an array, and a trapping region laterally displaced from the array; a second metastructure including a second substrate and a second electrode; a microfluidic channel between the first metastructure and the second metastructure; a voltage source configured to selectively apply an electric field between the first electrode and the second electrode; and a light source configured to selectively apply an excitation light to the microfluidic channel at a first location corresponding to the array, thereby to trap a nanoparticle at a second location corresponding to the trapping region. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479654 |
| CURRENT CPC | Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030362 | JIANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng JIANG (Gainesville, Florida); Zhuxiao GU (Gainesville, Florida); Ruwen TAN (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for methods of making substrates having an (AR) antireflective layer, substrates having an antireflective layer, devices including a substrate having an antireflective layer, and the like. The AR layer can have a total specular reflection of less than 10% at a wavelength of about 400-800 nm, and a height of about 500-1000 nm. |
| FILED | Tuesday, May 30, 2023 |
| APPL NO | 18/203436 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/118 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/186 (20130101) H01L 31/02168 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240031548 | Redden |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Blue River Technology Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lee Kamp Redden (Palo Alto, California) |
| ABSTRACT | Described are methods for identifying the in-field positions of plant features on a plant by plant basis. These positions are determined based on images captured as a vehicle (e.g., tractor, sprayer, etc.) including one or more cameras travels through the field along a row of crops. The in-field positions of the plant features are useful for a variety of purposes including, for example, generating three-dimensional data models of plants growing in the field, assessing plant growth and phenotypic features, determining what kinds of treatments to apply including both where to apply the treatments and how much, determining whether to remove weeds or other undesirable plants, and so on. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479504 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/2415 (20230101) Image Data Processing or Generation, in General G06T 7/593 (20170101) Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 20/38 (20220101) G06V 20/188 (20220101) Pictorial Communication, e.g Television H04N 13/128 (20180501) H04N 13/204 (20180501) H04N 13/239 (20180501) H04N 13/243 (20180501) Original (OR) Class H04N 13/271 (20180501) H04N 2013/0081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240023821 | MAJERUS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States Government as Represented by The Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steve J.A. MAJERUS (Washington, District of Columbia); Christian ZORMAN (Cleveland, Ohio); Hao CHONG (Cleveland, Ohio); Jonathan BASKIN (Cleveland, Ohio); Dustin J. TYLER (Cleveland, Ohio); Gilles PINAULT (Washington, District of Columbia) |
| ABSTRACT | Described herein is an apparatus (a flexible pulsation sensor (FPS) device) that provides wireless monitoring capability. The FPS device includes a FPS configured to wrap around a measurement target of a conduit, such as a synthetic vascular graft or a vessel of a patient. The FPS device also includes a flexible circuit board fitting including circuit elements. The circuit elements can include a pressure sensor that collects data related to displacement of the FPS related to a pressure of and/or within the measurement target; and a wireless transmitter that transmits the data related to the pressure of and/or within the measurement target wirelessly to an external device. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 18/025675 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0031 (20130101) A61B 5/0215 (20130101) A61B 5/02444 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024271 | Guthrie |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | O'Neil W. Guthrie (Flagstaff, Arizona) |
| ABSTRACT | The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/373838 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/215 (20130101) A61K 31/216 (20130101) Original (OR) Class A61K 31/365 (20130101) A61K 36/74 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024359 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Seattle Children's Hospital DBA Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yvonne Y. Chen (Los Angeles, California); Eugenia Zah (Los Angeles, California); Michael C. Jensen (Seattle, Washington) |
| ABSTRACT | A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR. |
| FILED | Friday, August 25, 2023 |
| APPL NO | 18/238210 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70596 (20130101) C07K 16/46 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024705 | XU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen XU (Ann Arbor, Michigan); Clifford Suhyun CHO (Ann Arbor, Michigan) |
| ABSTRACT | Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/478342 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0045 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026016 | O'NEIL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Thomas O'NEIL (Nashville, Tennessee); Matthew Hunter WILSON (Brentwood, Tennessee) |
| ABSTRACT | Disclosed are compositions and methods relating to genetically modified cells for the long-term expression of an antigen of interest. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/344214 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/468 (20130101) C07K 16/2866 (20130101) Original (OR) Class C07K 2317/75 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026026 | Weisbart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard H. Weisbart (Sepulveda, California); Robert N. Nishimura (Sepulveda, California) |
| ABSTRACT | The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482643 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/3053 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240023811 | Nikzad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Shouleh Nikzad (Valencia, California); Samuel R. Cheng (Walnut, California) |
| ABSTRACT | Systems and method for detecting light emitting biomarkers are described. The detection systems can be tuned to detect desired wavelengths emitted from biomarkers. The compact and cost-effective detection systems can provide detection results of the biomarkers in a timely manner. |
| FILED | Thursday, July 20, 2023 |
| APPL NO | 18/356027 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00016 (20130101) A61B 1/00032 (20130101) A61B 1/043 (20130101) A61B 1/00048 (20130101) A61B 1/0684 (20130101) A61B 5/0071 (20130101) Original (OR) Class A61B 5/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240026516 | THOMSEN, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DONALD L. THOMSEN, III (Yorktown, Virginia); SANKARA N. SANKARAN (Yorktown, Virginia); JOEL A. ALEXA (HAMPTON, Virginia) |
| ABSTRACT | Methods for making layered materials and layered materials including high atomic number metals and metal alloys adhered to surfaces are provided. Such surfaces may be oxygen or hydroxyl rich surfaces. Certain methods include depositing a tie down layer of a first metal or metal alloy particles onto a first surface of base material and depositing a high atomic number metal or metal alloy layer onto the first surface after depositing the tie down layer, wherein particles comprising the high atomic number metal or metal alloy layer have a higher atomic number than the first metal or metal alloy particles. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/375212 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/043 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/02 (20130101) C23C 4/08 (20130101) Original (OR) Class C23C 4/134 (20160101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027342 | Weisberger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua M. Weisberger (Newport News, Virginia); Brett F. Bathel (Newport News, Virginia) |
| ABSTRACT | A real-time reference free background oriented schlieren system is provided. One embodiment includes a display device capable of generating an image pattern projected onto a retroreflective background. A beam splitter is used to transmit a portion of the projected image pattern towards a reference image sensor and another portion of the image pattern towards the retroreflective background and past a density object. The retroreflective background reflects the projected pattern back through the beam splitter and onto a signal imaging sensor. Collected data from the reference image sensor and the signal image sensor may be processed in real-time. The image pattern may be altered as necessary without requiring a new reference image, reducing the amount of time required to set up and adjust the system. A display device may be capable of switching between a schlieren visualization capability to a shadowgraph system allowing for the use of two different imaging techniques. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/375025 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/2513 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/455 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028968 | HARRIVEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANGELA R. HARRIVEL (Poquoson, Virginia); Chad L. Stephens (Poquoson, Virginia); Kellie D. Kennedy (Poquoson, Virginia); Alan T. Pope (Poquoson, Virginia) |
| ABSTRACT | Aspects of the present disclosure are directed to devices, systems, and methods for optimized integration of a human operator with a machine for safe and efficient operation. Accordingly, aspects of the present disclosure are directed to systems, methods, and devices which evaluate and determine a cognitive state of an operator, and allocate tasks to either the machine and/or operator based on the cognitive state of the operator, among other factors. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/374923 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/18 (20130101) A61B 5/7264 (20130101) Card, Board, or Roulette Games; Indoor Games Using Small Moving Playing Bodies; Video Games; Games Not Otherwise Provided for A63F 13/21 (20140901) A63F 13/42 (20140902) A63F 13/67 (20140902) A63F 13/212 (20140902) Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/015 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Original (OR) Class Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029894 | JUTLA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida); University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antarpreet S. JUTLA (Gainesville, Florida); Moiz USMANI (Gainesville, Florida); Rita COLWELL (College Park, Maryland) |
| ABSTRACT | The present disclosure provides systems and methods for predicting the occurrence of an outbreak of an infectious disease. One such method includes acquiring environmental risk factor data associated with a particular disease, wherein the environmental risk factor data corresponds to a particular geographic region; acquiring social risk factor data associated with the particular disease; applying a prediction algorithm to the environmental and social risk factor data to generate a disease risk model for generating at least a trigger prediction and a transmission prediction for a disease-causing pathogen at the particular geographic region; generating the trigger prediction by applying the disease risk model to a forecast of data for a first lead time for the particular geographic region; and/or generating the transmission prediction by applying the disease risk model to the transmission prediction for a second lead time for the particular geographic region. Other methods and systems are also provided. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/374237 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) Original (OR) Class G16H 50/50 (20180101) G16H 50/80 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240030269 | Hoenk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Michael E. Hoenk (Valencia, California); April D. Jewell (Los Angeles, California); Todd J. Jones (Altadena, California); Shouleh Nikzad (Valencia, California) |
| ABSTRACT | Disclosed herein is a method of coating a detector. The method includes: providing the detector including a detector surface; performing a planarization process to the detector surface; performing a piranha clean process to the planarized surface; performing a slight etch to the piranha cleaned surface; performing an ammonium fluoride etching step to the slight etched surface to create a decontaminated surface. The decontaminated surface is an atomically flat silicon surface with surface and subsurface damage and contamination significantly reduced. A multilayer 2D-doped layer may be epitaxially grown on the decontaminated surface. The detector may provide high quantum efficiency with uniform and stable performance from room temperature to cryogenic temperatures. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356970 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1462 (20130101) H01L 27/14685 (20130101) Original (OR) Class H01L 27/14687 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240023546 | Werner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia); Arkion Life Sciences, LLC (New Castle, Delaware) |
| ASSIGNEE(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia); Arkion Life Sciences, LLC (New Castle, Delaware) |
| INVENTOR(S) | Scott J. Werner (Wellington, Colorado); Kenneth E. Ballinger, JR. (East Wakefield, New Hampshire) |
| ABSTRACT | In certain aspects, the present disclosure relates to a composition comprising a first compound that is a trigeminal nerve irritant, a second compound that is an animal repellent, and an acceptable carrier. The disclosure also relates to methods of repelling an animal from a substrate comprising applying to a substrate the compositions comprising a trigeminal nerve irritant and an animal repellent as described herein. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/223654 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 31/16 (20130101) A01N 33/06 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 17/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024404 | Arvik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SONOMACEUTICALS, LLC (Santa Rosa, California); The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Torey James Arvik (Santa Rosa, California); Rebecca Susan Lipson (Santa Rosa, California); Wallace H. Yokoyama (Albany, California) |
| ABSTRACT | The present disclosure relates to health benefits of Chardonnay seed products. |
| FILED | Thursday, June 22, 2023 |
| APPL NO | 18/339310 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 36/87 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024447 | JENKINS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Zoetis Services LLC (Parsippany, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. JENKINS (Davidsonville, Maryland); Jonathan L. SCHAEFFER (Raleigh, North Carolina) |
| ABSTRACT | The drinking water-based avian coccidiosis vaccine formulation and delivery system is structured to deliver a vaccine containing live Eimeria oocysts to poultry house brood chamber chicks. The vaccine is delivered to the chicks in a diluted form through the poultry house drinking water system. The chicks are inoculated with the drinking water-based avian coccidiosis vaccine when they consume the water containing the vaccine. The timing of the chicks' drinking water access to the diluted drinking water vaccine is critical. During the inoculation process, water is temporarily withheld from the chicks for a waiting period of about 3-5 hours, and access to the diluted drinking water-based vaccine is limited to an accessibility period of about 2 hours. Additionally, metering valves and/or terminal metering valve assemblies are manually or automatically closed when the when the drinking water lines are fully charged with the diluted vaccine. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868571 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/012 (20130101) Original (OR) Class A61K 2039/52 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240023703 | TARTAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES POSTAL SERVICE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William A. TARTAL (Baltimore, Maryland); Joel L. DEWNANDAN (Bladensburg, Maryland); Joram SHENHAR (Fairfax, Virginia) |
| ABSTRACT | A portable workstation apparatus includes: a pair of collapsible legs; and a work portion that is attached in a removable manner to the pair of collapsible lags via a pair of brackets. Each leg of the pair of collapsible legs includes: a frame; an extension connected to a first end of the frame; a lower post housed within a sleeve; an upper post; a hinge connecting the lower post and the upper post; a first brace connecting the extension to the sleeve; and a plurality of holes on an exterior face of the lower post or the upper post. Each leg is configured to collapse by folding the upper post towards the lower post via the hinge and rotating the extension toward the lower post. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/478420 |
| CURRENT CPC | Tables; Desks; Office Furniture; Cabinets; Drawers; General Details of Furniture A47B 3/08 (20130101) Original (OR) Class A47B 9/14 (20130101) A47B 21/02 (20130101) A47B 83/04 (20130101) A47B 2003/0824 (20130101) A47B 2009/145 (20130101) A47B 2200/004 (20130101) A47B 2200/0029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029008 | BRIGGMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chandra A. BRIGGMAN (Springfield, Virginia); Jane Elizabeth QUENK (Washington, District of Columbia); Timothy M. MORAN (National Harbor, Maryland); Thomas J. FOTI (Annandale, Virginia); Robert E. DIXON, JR. (Washington, District of Columbia) |
| ABSTRACT | A method, electronic device, and computer-readable storage medium for delivering supplemental physical and/or electronic content in association with a physical delivery item. Various embodiments include operations for receiving tracking data regarding a delivery item, determining, based on the tracking data, whether supplemental content is associated with the delivery item, and automatically scheduling delivery of the supplemental content when supplemental content is associated with the delivery item. Others embodiments include operations for obtaining tracking data regarding a delivery item; identifying, based on the tracking data, supplemental content associated with the delivery item; generating an electronic command to schedule delivery of the supplemental content at a delivery point of a user, the scheduled delivery being associated with a corresponding delivery date; and generating an electronic command to present, within a user interface, at least one of the electronic items of supplemental content to the user on the corresponding delivery date. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/477409 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/10 (20130101) G06Q 10/083 (20130101) G06Q 10/0833 (20130101) Original (OR) Class G06Q 10/1093 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 51/42 (20220501) H04L 51/234 (20220501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240029489 | McLellan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles P. McLellan (Fairfax, Virginia); Gabriel Michael Yessin (Arlington, Virginia); William Albert Tartal (Baltimore, Maryland) |
| ABSTRACT | Embodiments of a system and method for using a mobile device to assist with the efficient and secure delivery of item. The mobile device can assist an item deliver to lock or unlock secure item delivery receptacles. The mobile device can also notify an item deliverer about particular delivery conditions associated with particular delivery endpoints. The mobile device can further help the item deliverer to determine whether or not he or she is delivering the item to the correct location. |
| FILED | Monday, July 24, 2023 |
| APPL NO | 18/357946 |
| CURRENT CPC | Locks; Accessories Therefor; Handcuffs E05B 47/00 (20130101) E05B 2047/0072 (20130101) Electric Digital Data Processing G06F 21/44 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/083 (20130101) G06Q 50/32 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 9/00571 (20130101) G07C 9/00896 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240027680 | Cooksey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Alan Cooksey (Gaithersburg, Maryland); Paul Nathan Patrone (Washington Grove, Maryland); Matthew DiSalvo (Gaithersburg, Maryland); Jalal Sadeghi (Gaithersburg, Maryland) |
| ABSTRACT | A spatio-temporal profilometer performs time-resolved spatial profilometry and includes a substrate, a tapered optical collimator waveguide, a fluid channel, and a light-fluid interaction volume. The tapered optical collimator waveguide receives diverging light, internally reflects it, and collimates it. The fluid channel receives a fluid comprising microparticles and communicates the microparticles into the fluid channel. The light-fluid interaction volume is disposed in the fluid channel and provided by an overlap within the fluid channel of the collimated light from the tapered optical collimator waveguide and the fluid. The spatio-temporal profilometer produces product light from the collimated light in response to the microparticles interacting with the collimated light in the light-fluid interaction volume from which is determined a spatial and temporal profile of microparticles in the fluid channel. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/225002 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/105 (20130101) Original (OR) Class G02B 6/4206 (20130101) G02B 27/283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028879 | Buckley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sonia Mary Buckley (Buena Vista, Colorado); Adam Nykoruk McCaughan (Denver, Colorado); Andrew Martin Dienstfrey (Louisville, Colorado); Sae Woo Nam (Boulder, Colorado) |
| ABSTRACT | Embodiments of the present invention relate to systems and model-free methods for perturbing neural network hardware parameters and measure the neural network response that are implemented natively within the neural network hardware and without requiring a knowledge of the internal structure of the network. Embodiments of the present invention also relate to systems and methods for configuring neural network hardware such that the network automatically performs parameter multiplexed gradient descent, which include adding a time-varying perturbation to each hardware parameter base value to modulate the cost, broadcasting the modulated cost signal to all hardware parameters, and filtering out modulations so as to extract gradient information. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/223663 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/048 (20230101) G06N 3/063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20240024239 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW JERSEY INSTITUTE OF TECHNOLOGY (Newark, New Jersey) |
| ASSIGNEE(S) | NEW JERSEY INSTITUTE OF TECHNOLOGY (Newark, New Jersey) |
| INVENTOR(S) | Xiaoyang Xu (Livingston, New Jersey); Zhongyu Li (Harrison, New Jersey) |
| ABSTRACT | Ionizable cationic lipid compounds have an amine moiety from amino alcohols and a lipid moiety from a lipid synthesized via esterification. The ionizable cationic lipid compounds which comprise an amino alcohol mediated ionizable cationic lipid compound are useful for in vivo or in vitro delivery of one or more nucleic acid agents including DNA, siRNA, a microRNA, an mRNA, a RNAi, and a plasmid. |
| FILED | Monday, July 17, 2023 |
| APPL NO | 18/222839 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 9/1277 (20130101) A61K 31/711 (20130101) A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 47/22 (20130101) A61K 48/0033 (20130101) A61K 48/0091 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6436 (20130101) C12P 17/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240024302 | SAFFITZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (Boston, Massachusetts); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey E. SAFFITZ (Waban, Massachusetts); Bruce D. HAMMOCK (Davis, California); Sung Hee HWANG (Woodland, California) |
| ABSTRACT | Provided herein are methods of preventing, mitigating, decreasing, reversing and/or treating Arrhythmogenic Cardiomyopathy (ACM) in a subject in need thereof, comprising administering to the subject an effective amount of a compound of Formula I, a compounds of Formula II, or a compound of Formula III (I) (II), (III) wherein R1, R2, R3, n, R4, R4a, R5, m, R6, R7, and p are as defined herein. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 18/250504 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) A61K 31/4515 (20130101) Original (OR) Class A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240028106 | ELOR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AVIV ELOR (WALNUT CREEK, California); MICHAEL ORA POWELL (CAMPBELL, California); ASH SEYMOUR ROBBINS (SANTA CRUZ, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | AVIV ELOR (WALNUT CREEK, California); MICHAEL ORA POWELL (CAMPBELL, California); ASH SEYMOUR ROBBINS (SANTA CRUZ, California) |
| ABSTRACT | A system and method for utilizing virtual reality technology to provide and improve physical therapy care. Virtual reality devices may be utilized to facilitate telehealth visits in a three-dimensional medium where a digital avatar moves in accordance with the movement of a patient wearing a virtual reality device. Virtual reality devices may be used to provide and monitor exercises prescribed for a physical therapy patient. Virtual reality devices may be used to record, model, and analyze motion patterns of a physical therapy patient to assess relevant physical capability such as balance or motor control. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868743 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 13/40 (20130101) G06T 19/006 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240031548 | Redden |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Blue River Technology Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lee Kamp Redden (Palo Alto, California) |
| ABSTRACT | Described are methods for identifying the in-field positions of plant features on a plant by plant basis. These positions are determined based on images captured as a vehicle (e.g., tractor, sprayer, etc.) including one or more cameras travels through the field along a row of crops. The in-field positions of the plant features are useful for a variety of purposes including, for example, generating three-dimensional data models of plants growing in the field, assessing plant growth and phenotypic features, determining what kinds of treatments to apply including both where to apply the treatments and how much, determining whether to remove weeds or other undesirable plants, and so on. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479504 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/2415 (20230101) Image Data Processing or Generation, in General G06T 7/593 (20170101) Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 20/38 (20220101) G06V 20/188 (20220101) Pictorial Communication, e.g Television H04N 13/128 (20180501) H04N 13/204 (20180501) H04N 13/239 (20180501) H04N 13/243 (20180501) Original (OR) Class H04N 13/271 (20180501) H04N 2013/0081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240027380 | YU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yihua (Bruce) YU (Ellicott City, Maryland); Marc TARABAN (North Potomac, Maryland); Katharine T. BRIGGS (Germantown, Maryland) |
| ABSTRACT | Methods for non-invasively identifying substandard or counterfeit products, e.g., vaccines, using nuclear magnetic resonance. The methods provide manufacturers with new approaches to identify parameters to assist users with the identification of substandard or counterfeit products. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356554 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/04 (20130101) G01N 24/082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027628 | Kreichauf et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Ruth Dagmar Kreichauf (River Falls, Wisconsin); Reed R. May (Seminole, Florida) |
| ABSTRACT | A system comprises a GNSS receiver that receives a GNSS signal and produces GNSS measurements; a plurality of inertial sensors that produce inertial data; and a navigation system comprising a Kalman filter and an inertial navigation unit. The Kalman filter receives the GNSS measurements and calculates pseudo-range residuals, delta-range residuals, pseudo-range chi square values, delta-range chi square values, accelerometer bias estimates, and gyroscope bias estimates. A spoof detection system communicates with the Kalman filter and comprises a set of detection monitors that determine an integrity of the GNSS measurements. The detection monitors detect if the pseudo-range residuals, the delta-range residuals, the pseudo-range chi-square values, the delta-range chi-square values, the accelerometer bias estimates, or the gyroscope bias estimates, go beyond a fail threshold indicating that the GNSS signal is abnormal. When one or more of the detection monitors indicates that the GNSS signal is abnormal, a spoof event alert is outputted. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/872986 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/47 (20130101) G01S 19/215 (20130101) Original (OR) Class G01S 19/393 (20190801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240027687 | KNIGHT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MARK WILLIAM KNIGHT (El Segundo, California); STEPHANIE ROXANE SANDOR-LEAHY (El Segundo, California); LAKSHMINARAYANAN RAVI NARASIMHAN (Redondo Beach, California) |
| ABSTRACT | A method of making a photonic integrated circuit (PIC) is provided. The method comprises depositing a functional resist material layer over a substrate, disposing and pressing a stamp with a plurality of nanopatterns into the functional resist material for a period of time, and removing the stamp from the functional resist material to provide nanofeatures that are inverted versions of the nanopatterns, wherein the nanofeatures form one or more optical elements. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479418 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/136 (20130101) Original (OR) Class G02B 2006/12038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240028555 | Pawlowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert Pawlowski (Beaverton, Oregon); Sriram Aananthakrishna (Lubbock, Texas); Shruti Sharma (Beaverton, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Pawlowski (Beaverton, Oregon); Sriram Aananthakrishna (Lubbock, Texas); Shruti Sharma (Beaverton, Oregon) |
| ABSTRACT | Techniques for multi-dimensional network sorted array intersection. A first switch of a plurality of switches of an apparatus may receive a first element of a first array from a first compute tile of the plurality of compute tiles and a first element of a second array from a second compute tile of the plurality of compute tiles. The first switch may determine that the first element of the first array is equal to the first element of the second array. The first switch may cause the first element of the first array to be stored as a first element of an output array, the output array to comprise an intersection of the first array and the second array. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/375359 |
| CURRENT CPC | Electric Digital Data Processing G06F 15/80 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, January 25, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240125.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page