FedInvent™ Patent Applications
Application Details for Thursday, February 01, 2024
This page was updated on Tuesday, June 18, 2024 at 02:13 PM GMT
Department of Health and Human Services (HHS)
| US 20240032790 | Patel et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin); Coherence Consulting LLC (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dwani Patel (Milwaukee, Wisconsin); Al Hafeez Dhalla (Durham, North Carolina); Christian B. Viehland (Durham, North Carolina); Daniel M. Lipinski (Milwaukee, Wisconsin) |
| ABSTRACT | Laser-Speckle Contrast imaging apparatus configured to assess and quantify motion associated with an object and, in a specific case of an eye—retinal vascular anatomy and hemodynamics and generate substantially contrast-free maps of retinal blood flow over a wide field-of-view at up to 590 fps and under short exposure durations (>50 μs), is applicable for diagnosis, study, and management of neurodegenerative conditions (i.e. mild cognitive impairment and Alzheimer's disease) and systemic cardiovascular diseases (i.e. athero- and arteriosclerosis, coronary artery occlusion, and hypertension). The apparatus employs a) a set of apertures substantially blocking light, delivered from a source of light to an illumination arm of the apparatus, from impinging onto an axial point of the front surface of the lens of the illumination arm, and b) polarization gating between the illumination and light-collecting arms of the apparatus. In one implementation, the apparatus is configured to allow for irradiation of the object with an optical field a degree of coherence and/or spectral content of which are varied delivered through the same optical train including the set of apertures. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 18/550776 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/14 (20130101) A61B 3/1241 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240032854 | Mannoh et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
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| INVENTOR(S) | Emmanuel A. Mannoh (Nashville, Tennessee); Anita Mahadevan-Jansen (Nashville, Tennessee) |
| ABSTRACT | One aspect of the invention relates to a method for intraoperative detection of parathyroid gland viability in a surgery, comprising obtaining speckle contrast images of a parathyroid gland of a patent; and displaying the speckle contrast images of the parathyroid gland in real-time. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/377867 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/0075 (20130101) A61B 5/0086 (20130101) A61B 5/415 (20130101) Original (OR) Class A61B 5/418 (20130101) A61B 5/742 (20130101) A61B 5/4227 (20130101) A61B 34/20 (20160201) A61B 2034/2055 (20160201) A61B 2505/05 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 21/6456 (20130101) G01N 2021/6439 (20130101) G01N 2201/0221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033233 | Mansour et al. |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heidi Mansour (Tucson, Arizona); Victor Ruiz (Tucson, Arizona); Sally E. Dickinson (Tucson, Arizona); Clara N. Curiel (Tucson, Arizona); Hsiao-Hui Chow (Tucson, Arizona); Georg T. Wondrak (Tucson, Arizona) |
| ABSTRACT | Provided herein are compositions and methods for delivering pharmaceutical agents. In particular, provided herein are topical formulations of resatorvid for use in treating and preventing skin pathologies. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 18/018924 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) A61K 31/18 (20130101) Original (OR) Class A61K 47/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033240 | Xu et al. |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
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| INVENTOR(S) | Peisheng Xu (Chapin, South Carolina); Eleni Markoutsa (Cayce, South Carolina) |
| ABSTRACT | The preparation of dual functionalized nanoparticles is generally provided along with their application. The dual functionalized nanoparticles provide dual targeting and can effectively pass the blood brain barrier and target brain tissue. The dual targeted and dual responsive nanoparticles are functionalized to include at least two different ligands that are capable of transport across the blood brain barrier. The nanoparticles can be prepared from polymeric materials that can be biocompatible, provide long circulation life in a body, and be successfully ligated to both functionalities by use of acid-sensitive and/or redox potential-sensitive bonds for delivery across the blood brain barrier and delivery of a payload to brain tissue. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479393 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) Original (OR) Class A61K 47/54 (20170801) A61K 47/55 (20170801) A61K 47/6933 (20170801) A61K 47/6935 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033242 | Shah et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Nisarg Shah (San Diego, California); David A. McBride (San Diego, California); Nunzio Bottini (La Jolla, California) |
| ABSTRACT | Described herein are compositions and methods for treating inflammatory arthritic conditions tint are effective systemically without causing generalized immunosuppression when administered locally into an inflammatory arthritis-affected joint or a draining lymph node of the arthritis-affected joint of a patient. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/474108 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5031 (20130101) A61K 31/203 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033254 | Abdallah et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
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| INVENTOR(S) | Chadi Abdallah (New Haven, Connecticut); John Krystal (New Haven, Connecticut); Ronald Duman (New Haven, Connecticut); Gerard Sanacora (New Haven, Connecticut) |
| ABSTRACT | The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/483225 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0053 (20130101) A61K 31/135 (20130101) A61K 31/436 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/24 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033265 | Tyner et al. |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
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| INVENTOR(S) | Jeffrey W Tyner (Portland, Oregon); Cristina Tognon (Portland, Oregon); Brian J Druker (Portland, Oregon); Daniel Bottomly (Beaverton, Oregon); Beth Wilmot (Portland, Oregon); Stephen Kurtz (Portland, Oregon); Samantha Savage Stevens (Portland, Oregon); Nicola Long (Portland, Oregon); Anna Reister Schultz (Beaverton, Oregon); Elie Traer (Portland, Oregon); Shannon K McWeeney (Portland, Oregon) |
| ABSTRACT | The present invention relates to useful methods of treating Acute Myeloid Leukemia (AML) in a human. in the presence of gene mutations. |
| FILED | Friday, July 26, 2019 |
| APPL NO | 17/263531 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033293 | Stephan |
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| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Matthias Stephan (Seattle, Washington) |
| ABSTRACT | Implantable scaffolds that treat solid tumors and escape variants and that provide effective vaccinations against cancer recurrence are described. The scaffolds include genetically-reprogrammed lymphocytes and a lymphocyte-activating moiety. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/476774 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/70 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 38/177 (20130101) A61K 38/1774 (20130101) A61K 38/2086 (20130101) A61K 39/0011 (20130101) A61K 45/06 (20130101) A61K 47/34 (20130101) A61K 2039/54 (20130101) A61K 2039/575 (20130101) A61K 2039/5158 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/005 (20130101) A61L 31/06 (20130101) A61L 31/16 (20130101) A61L 31/042 (20130101) A61L 31/046 (20130101) A61L 31/146 (20130101) A61L 2300/416 (20130101) A61L 2300/606 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) C12N 2501/06 (20130101) C12N 2501/998 (20130101) C12N 2501/999 (20130101) C12N 2510/00 (20130101) C12N 2533/00 (20130101) C12N 2533/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033298 | KAUSHAL |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
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| INVENTOR(S) | Sunjay KAUSHAL (Chicago, Illinois) |
| ABSTRACT | Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/459685 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Original (OR) Class A61K 38/19 (20130101) A61K 38/195 (20130101) A61K 38/1833 (20130101) A61K 38/1866 (20130101) A61K 38/1891 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033317 | LIU et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's National Medical Center (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang LIU (Potomac, Maryland); Yin WANG (Washington, District of Columbia); Yan LIU (Washington, District of Columbia); Christopher BAILEY (Merritt Island, Florida) |
| ABSTRACT | The present invention relates to treating TP53-mutated AML using a Hypoxia-Inducible Factor (HIF inhibitor). The invention further relates to a new HIF inhibitor formulation with longer half-life and significantly improved therapeutic effect for TP53-mutated AML. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/904142 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 38/08 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033318 | PEI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dehua PEI (Columbus, Ohio); John W. CHRISTMAN (Columbus, Ohio); Manjula KARPURAPU (Columbus, Ohio); Patrick G. DOUGHERTY (Columbus, Ohio) |
| ABSTRACT | Described are peptides and peptide conjugates comprising CN binding motifs (CNBM) which inhibit the CN-NFAT interaction. In some embodiments, the peptides comprise: (i) CNBM; (ii) a hydrophobic, non-peptidic moiety (RH) which interacts with the hydrophobic pocket on a CN protein; (iii) a sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-, wherein each of AAU2, AAU3, AAU4, AAU5, and AAU6, is, independently, optional, and each of AAU1, AAU2, AAU3, AAU4, AAU5, and AAU6 when present is independently an amino acid as defined herein; or (iv) combinations thereof. In some embodiments, RH is conjugated to the N- or C-terminus of the CNBM. In some embodiments, the sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6- is conjugated to the N- or C terminus of the CNBM. In some embodiments, the peptides comprise: CNBM and RH. In some embodiments. In some embodiments, the peptides comprise: CNBM and AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-. In some embodiments, the peptides of the disclosure CNBM and RH. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/104643 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) Original (OR) Class A61K 47/64 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033340 | OH et al. |
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| FUNDED BY |
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| APPLICANT(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| ASSIGNEE(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| INVENTOR(S) | SangKon OH (Baltimore, Maryland); Sandra ZURAWSKI (Midlothian, Texas); Gerard ZURAWSKI (Midlothian, Texas) |
| ABSTRACT | Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers. |
| FILED | Tuesday, June 06, 2023 |
| APPL NO | 18/329696 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/395 (20130101) A61K 39/3955 (20130101) A61K 39/39541 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/005 (20130101) C07K 16/2878 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033341 | Gristick et al. |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); THE ROCKEFELLER UNIVERSITY (NEW YORK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harry Gristick (Pasadena, California); Pamela J. Bjorkman (Altadena, California); Harald Hartweger (New York, New York); Michel C. Nussenzweig (New York, New York) |
| ABSTRACT | Provided herein are HIV immunogens and uses thereof for generating an immune response in a subject. This disclosure further provides a method for treating or preventing a human immunodeficiency type I (HIV-I) infection in a subject using the disclosed HIV immunogens and/or antibodies generated by any of the methods disclosed herein. |
| FILED | Thursday, June 22, 2023 |
| APPL NO | 18/340008 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033348 | DICKEY et al. |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); PULMOTECT, INC. (Houston, Texas); THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Burton F. DICKEY (Houston, Texas); Michael J. TUVIM (Houston, Texas); Scott E. EVANS (Bellaire, Texas); Magnus HOOK (College Station, Texas); David P. HUSTON (College Station, Texas); Margarita MARTINEZ-MOCZYGEMBA (College Station, Texas); Brenton SCOTT (Houston, Texas) |
| ABSTRACT | Certain embodiments are directed to compositions and methods for attenuating allergic responses in a subject. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/484667 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 38/164 (20130101) A61K 39/35 (20130101) Original (OR) Class A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) Transmission H04B 1/04 (20130101) H04B 1/16 (20130101) H04B 1/40 (20130101) H04B 1/713 (20130101) H04B 1/715 (20130101) H04B 1/7156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033354 | Jin et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
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| INVENTOR(S) | Rongsheng Jin (Irvine, California); Peng Chen (Irvine, California) |
| ABSTRACT | The present invention has designed and produced a family of recombinant proteins that could provide broad-spectrum protection/neutralization against most subtypes of TcdB, and therefore could be developed into therapies against GDI. The designs of these novel proteins are based on the first 3D structure of TcdB1 in complex with its receptor CSPG4 that was recently determined. The present invention demonstrates that these newly designed proteins are more potent and provide broader-spectrum protection than the commercial antibody bezlotoxumab in terms of neutralizing diverse subtypes of TcdB. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 18/043878 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4164 (20130101) A61K 31/7048 (20130101) A61K 38/14 (20130101) A61K 39/40 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/705 (20130101) C07K 16/40 (20130101) C07K 2317/569 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033373 | Tirrell et al. |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Tirrell (Chicago, Illinois); James L. Labelle (Chicago, Illinois); Mathew Schnorenberg (Chicago, Illinois); Jeffrey A. Hubbell (Chicago, Illinois); Elyse A. Watkins (Chicago, Illinois) |
| ABSTRACT | Provided herein are nanoparticles to encapsulate therapeutic agents and methods of use thereof for intracellular delivery and disease treatment. In particular, the present disclosure provides polymersomes for use in the delivery of therapeutic agents, e.g. stapled peptides, to diseased (e.g. cancer) cells. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 18/043286 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/6849 (20170801) A61K 47/6915 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033403 | Howell et al. |
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| APPLICANT(S) | University of Maine System Board of Trustees (Orono, Maine); University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Caitlin Lake Howell (Veazie, Maine); Marissa J. Andersen (South Bend, Indiana); Ana Lidia Flores Mireles (South Bend, Indiana) |
| ABSTRACT | Presented herein are devices, systems, and methods related to liquid infused substrates for use in medical applications. Adhesion of proteins, pathogens, and other substances to medical devices presents an issue. Proteins from the surrounding environment adhere to medical devices, which may, under certain conditions, result in the adhesion of pathogens to the medical device. The presence of these pathogens may result in infections when a medical device is inserted or otherwise placed in vivo (in whole or in part), which may require the removal of the device and/or treatment of the subject with antibiotics. Changing the surface properties of such devices can alter which proteins, pathogens, and/or other substances adhere and/or adsorb to the surface. Accordingly, in some embodiments, the present disclosure provides for technologies for altering surface adhesion and/or absorption of proteins, pathogens and/or other substances by infusing/impregnating a substrate of the device with an impregnation fluid. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/224842 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/06 (20130101) A61L 29/085 (20130101) Original (OR) Class A61L 2300/404 (20130101) A61L 2300/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033514 | Bhadra et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Niloy Bhadra (Cleveland, Ohio); Narendra Bhadra (Cleveland, Ohio); Kevin L. Kilgore (Cleveland, Ohio); Scott Lempka (Cleveland, Ohio); Jesse Wainright (Cleveland, Ohio); Tina Vrabec (Cleveland, Ohio); Manfred Franke (Cleveland, Ohio) |
| ABSTRACT | One aspect of the present disclosure is a system including a waveform generator, a controller, and an electrical contact. The waveform generator is for generating an electrical nerve conduction block (ENCB). The controller is coupled with the waveform generator. The controller is configured to receive an input comprising at least one parameter to adjust the ENCB. The electrical contact is coupled with the waveform generator. The electrical contact is configured to be placed into contact with a nerve. The electrical contact comprises a high charge capacity material that prevents formation of damaging electro-chemical products at a charge delivered by the ENCB. The electrical contact is configured to deliver the ENCB to the nerve to block transmission of a signal related to a pain through the nerve. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/482926 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101) A61N 1/36021 (20130101) A61N 1/36057 (20130101) A61N 1/36071 (20130101) Original (OR) Class A61N 1/36175 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033516 | GANGULY et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karunesh GANGULY (San Francisco, California); Preeya KHANNA (San Francisco, California); Kyungsoo KIM (Oakland, California) |
| ABSTRACT | Methods and apparatuses for treating a patient having a brain lesion (e.g., a stroke patient) by applying a charge-balanced, low-frequency alternating current stimulation (ACS) to a region of the patient's brain immediately before and/or during a directed movement. The charge-balanced, low-frequency ACS may have a depolarizing phase that is slower than the hyperpolarizing phase (e.g., the depolarizing phase may have a frequency of 15 Hz or less and the hyperpolarizing phase with a frequency greater than 15 Hz). The ACS stimulation field may be greater than 1.5 V/m. The ACS may be applied during a preferred excitation phase. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 18/264926 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36103 (20130101) Original (OR) Class A61N 1/36139 (20130101) A61N 1/36171 (20130101) A61N 1/36178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033542 | CAIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles A. CAIN (Ann Arbor, Michigan); Adam D. MAXWELL (Ann Arbor, Michigan); Zhen XU (Ann Arbor, Michigan); Kuang-Wei LIN (Ann Arbor, Michigan) |
| ABSTRACT | Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P−) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485904 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 2017/320069 (20170801) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/0039 (20130101) A61N 2007/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033737 | Flanagan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa A. Flanagan (Irvine, California); Alan Y. L. Jiang (Irvine, California); Jaclyn Nicole Hanamoto (Irvine, California); Clarissa C. Ro (Irvine, California) |
| ABSTRACT | The disclosure provides devices, methods and systems for continuous dielectrophoresis cell sorting to isolate different populations of cells, and applications thereof. |
| FILED | Wednesday, July 26, 2023 |
| APPL NO | 18/226739 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0645 (20130101) B01L 2300/0883 (20130101) B01L 2400/0424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034765 | GREENBERG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael E. GREENBERG (Cambridge, Massachusetts); Ee-Lynn YAP (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to pharmaceutical compositions comprising at least one Scg2 neuropeptide, as well as cell culture media or kits comprising such Scg2 neuropeptides. Also described herein are nucleic acids, vectors, or viral vectors encoding at least one Scg2 neuropeptide. In further aspects, described herein are methods of treating a memory-associated disorder, a learning disability, a neurodegenerative disease or disorder, or epilepsy with a pharmaceutical composition, nucleic acid, vector, or viral vector as described herein. In further aspects, described herein are detection methods of memory-associated analytes, such as Scg2 neuropeptides. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 18/265523 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/575 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2800/52 (20130101) G01N 2800/2814 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034766 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia State Research Foundation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhi-Ren Liu (Marietta, Georgia); Jenny Yang (Marietta, Georgia) |
| ABSTRACT | Anti-angiogenic agents or polypeptides have an amino acid segment substantially similar to domain one of CD2. The polypeptide has a β-sheet formed by two segments. Methods of using such agents and polypeptide are also included. |
| FILED | Tuesday, February 14, 2023 |
| APPL NO | 18/169097 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1774 (20130101) A61K 45/06 (20130101) Peptides C07K 14/70507 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034778 | Desai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alec A. Desai (Ann Arbor, Michigan); Peter M. Tessier (Ann Arbor, Michigan); Matthew D. Smith (Ann Arbor, Michigan); Yulei Zhang (Ann Arbor, Michigan) |
| ABSTRACT | The disclosure is directed to a monoclonal antibody. or an antigen-binding fragment thereof. directed against fibrils of amyloid beta (Aβ) peptides, as well as a method of treating and diagnosing neurodegenerative diseases using the monoclonal antibody. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 18/258758 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/52 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034788 | Sage et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julien Sage (Menlo Park, California); Edward Graves (Stanford, California); Yoko Nishiga (Redwood City, California) |
| ABSTRACT | Methods and compositions are provided for the treatment of cancer with a targeted therapy in combination with radiation. Administration of an effective dose or series of doses of a CD47 blocking agent, i.e. an agent that blocks the interaction between CD47 and SIRPα, is combined with radiation therapy to provide for an abscopal effect. In some embodiments the cancer is a metastatic cancer, or a cancer with a high likelihood of metastasis. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 18/020402 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 16/2896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034799 | GONSKY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca GONSKY (Los Angeles, California); Alka POTDAR (Cumming, Georgia) |
| ABSTRACT | Described herein are methods and systems for identifying subpopulations of inflammatory bowel disease (IBD) patients utilizing genetic markers that are associated with severe Crohn's disease. Further provided are therapies useful for treating these subpopulations of IBD patients based, at least in part, on the genetic markers provided herein. |
| FILED | Wednesday, May 31, 2023 |
| APPL NO | 18/326912 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Peptides C07K 16/2875 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034981 | Rinaudo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paolo Rinaudo (San Francisco, California); Seok Hee Lee (San Francisco, California) |
| ABSTRACT | Devices, systems, and methods for evaluating the viability of embryos are disclosed. In particular, devices, systems, and methods for measuring internal and external pH of an embryo, electrolytes, and oxidative stress markers for evaluating developmental potential of an embryo are provided. The methods disclosed herein should improve in vitro fertilization (IVF) outcomes by reducing inadvertent transfer of non-viable embryos. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 18/027292 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 41/26 (20130101) Original (OR) Class C12M 41/38 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0604 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035006 | Yamano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); University of Tokyo (Tokyo, Japan); The United States of America, as Represented by the Secretary Dept of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); University of Tokyo (Tokyo, Japan); The United States of America, as Represented by the Secretary Dept of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Takashi Yamano (Tokyo, Japan); Hiroshi Nishimasu (Tokyo, Japan); Bernd Zetsche (Cambridge, Massachusetts); Ian Slaymaker (Cambridge, Massachusetts); Yinqing Li (Cambridge, Massachusetts); Iana Fedorova (Cambridge, Massachusetts); Kira Makarova (Bethesda, Maryland); Linyi Gao (Cambridge, Massachusetts); Eugene Koonin (Bethesda, Maryland); Feng Zhang (Cambridge, Massachusetts); Osamu Nureki (Tokyo, Japan) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/986277 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 1/306 (20130101) C07K 2299/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/102 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/30 (20190201) G16C 20/50 (20190201) G16C 20/70 (20190201) G16C 60/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035007 | KONERMANN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); University of Tokyo (Tokyo, Japan); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); University of Tokyo (Tokyo, Japan); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Silvana KONERMANN (Cambridge, Massachusetts); Alexandro TREVINO (Cambridge, Massachusetts); Mark BRIGHAM (Cambridge, Massachusetts); Fei RAN (Cambridge, Massachusetts); Patrick HSU (Cambridge, Massachusetts); Chie-yu LIN (Cambridge, Massachusetts); Osamu NUREKI (Tokyo, Japan); Hiroshi NISHIMASU (Tokyo, Japan); Ryuichiro ISHITANI (Tokyo, Japan); Feng ZHANG (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089023 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Enzymes C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035008 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Abudayyeh (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Lukas Villiger (Cambridge, Massachusetts); Justin Lim (Boston, Massachusetts); Christopher W. Fell (Cambridge, Massachusetts) |
| ABSTRACT | Genome editing tools for use in systems designed to deliver large genetic elements are disclosed herein. A genome editing system is described, which includes i) an R2 element enzyme or other non-LTR site specific retrotransposon element and ii) a payload RNA, wherein the payload RNA comprises an insertion region and optionally one or more of a 5′ homology region, a 3′ homology region, and a protein binding element, wherein the insertion region comprises a template for a small or large nucleic acid insertion into the genome, and wherein the R2 element enzyme or other non-LTR site specific retrotransposon element comprises a targeting domain, a reverse transcriptase domain, and a nickase domain. Also disclosed are cells edited using such a genome editing system, methods for editing a genome, and compositions comprising cells edited with this genomic editing system. |
| FILED | Monday, April 17, 2023 |
| APPL NO | 18/301732 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/102 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035019 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William H. Robinson (Palo Alto, California); Yann Chong Tan (Palo Alto, California); Jeremy Sokolove (Mountain View, California) |
| ABSTRACT | Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest. |
| FILED | Thursday, June 28, 2018 |
| APPL NO | 16/022579 |
| CURRENT CPC | Peptides C07K 16/00 (20130101) C07K 16/1242 (20130101) C07K 16/1271 (20130101) C07K 2317/21 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 2458/10 (20130101) G01N 2500/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035021 | Weinberger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leor S. Weinberger (Oakland, California); Timothy J. Notton (San Francisco, California) |
| ABSTRACT | Provided are methods and compositions for generating a deletion library, and methods and compositions for generating and identifying a defective interfering particle (DIP). Also provided are transposon cassettes. A subject method can include: inserting a transposon cassette comprising a target sequence for a sequence specific DNA endonuclease into a population of circular target DNAs to generate a population of transposon-inserted circular target DNAs; contacting the population of transposon-inserted circular target DNAs with the sequence specific DNA endonuclease to generate a population of cleaved linear target DNAs; contacting the population of cleaved linear target DNAs with one or more exonucleases to generate a population of deletion DNAs; and circularizing the deletion DNAs to generate a library of circularized deletion DNAs. The population of circular target DNAs can include viral genomic DNA. Also provided ae human immunodeficiency virus (HIV) deletion mutants, e.g., interfering, conditionally replicating, HIV deletion mutants, and related constructs. |
| FILED | Monday, February 20, 2023 |
| APPL NO | 18/171578 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/66 (20130101) C12N 15/867 (20130101) C12N 15/1065 (20130101) C12N 15/1082 (20130101) Original (OR) Class C12N 2310/533 (20130101) C12N 2800/80 (20130101) C12N 2800/90 (20130101) C12N 2800/107 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 2563/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035031 | Borrajo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Borrajo (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides compositions and methods of using these compositions to mediate a targeted trans-splicing event on a pre-mRNA in a cell. |
| FILED | Tuesday, August 15, 2023 |
| APPL NO | 18/449850 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035035 | Pyle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anna Marie Pyle (New Haven, Connecticut); Akiko Iwasaki (New Haven, Connecticut); Tianyang Mao (New Haven, Connecticut) |
| ABSTRACT | The present disclosure provides small hairpin nucleic acid molecules capable of stimulating interferon production. The nucleic acid molecules of the present disclosure has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5′-triphosphate or a 5′-diphosphate. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 18/266075 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 38/212 (20130101) A61K 38/215 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class C12N 2310/531 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035048 | ZHANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (CAMBRIDGE, Massachusetts); Massachusetts Institute of Technology (CAMBRIDGE, Massachusetts) |
| INVENTOR(S) | Feng ZHANG (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/217352 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 67/0278 (20130101) A01K 2217/05 (20130101) A01K 2217/07 (20130101) A01K 2217/052 (20130101) A01K 2217/072 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/01 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 15/86 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/8213 (20130101) C12N 15/8509 (20130101) C12N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035060 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SYNVITROBIO, INC. (San Leandro, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary Z. Sun (San Leandro, California); Richard Mansfield (San Leandro, California); Abel C. Chiao (San Leandro, California); Kelly S. Trego (San Leandro, California) |
| ABSTRACT | Provided herein, in one aspect, is a composition for in vitro transcription and translation, comprising: a treated cell lysate derived from one or more organisms such as bacteria, archaea, plant or animal; a plurality of supplements for gene expression; an energy recycling system for providing adenosine triphosphate and recycling adenosine diphosphate; and an engineered propeptide operably linked to a stabilizing domain. Methods for making and using the same are also provided. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311555 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) C12P 21/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035065 | Sode et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Koji Sode (Chapel Hill, North Carolina); Jeffrey Dick (Chapel Hill, North Carolina); Nicole Walker (Chapel Hill, North Carolina); David Probst (Chapel Hill, North Carolina); Inyoung Lee (Chapel Hill, North Carolina); Shouhei Takamatsu (Chapel Hill, North Carolina) |
| ABSTRACT | Devices and methods are disclosed for measuring a target substance concentration in a sample utilizing a biosensor. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 18/265797 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) C12Q 1/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035068 | Samusik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolay Samusik (Mountain View, California); Garry P. Nolan (Redwood City, California); Yury Goltsev (Stanford, California); David Robert McIlwain (Palo Alto, California) |
| ABSTRACT | A method for analyzing planar sample is provided. In some cases the method comprises: (a) labelling the planar sample with a capture agent that is linked to a nucleic acid, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the nucleic acid, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177750 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6818 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035088 | Salk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse Salk (Seattle, Washington); Lawrence A. Loeb (Bellevue, Washington); Michael Schmitt (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465946 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035092 | MITIN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SAPERE BIO, INC. (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natalia MITIN (Durham, North Carolina) |
| ABSTRACT | The disclosure relates to methods, kits and systems for predicting patient outcomes for patients undergoing medical procedures. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 18/266013 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035095 | Kurtz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Carlos, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/481092 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 35/20 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035101 | O'Connor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David O'Connor (Madison, Wisconsin); Thomas Friedrich (Madison, Wisconsin); Marc Johnson (Columbia, Missouri) |
| ABSTRACT | Disclosed herein are methods for identifying antigenic variants from cryptic lineages arising in a virus population and methods of using the identified antigenic variants. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363520 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6804 (20130101) C12Q 1/6869 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035974 | RAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Govind RAO (Ellicott City, Maryland); Yordan KOSTOV (Ellicott City, Maryland); Mustafa AL-ADHAMI (Silver Spring, Maryland); Chandrasekhar GURRAMKONDA (Baltimore, Maryland) |
| ABSTRACT | A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/486202 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 2300/0867 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2304/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/645 (20130101) G01N 21/6428 (20130101) Original (OR) Class G01N 2021/0112 (20130101) G01N 2333/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035979 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Ji-Xin Cheng (Newton, Massachusetts); Haonan Lin (Allston, Massachusetts) |
| ABSTRACT | Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain. |
| FILED | Thursday, August 17, 2023 |
| APPL NO | 18/235279 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 5/001 (20130101) G06T 2207/20081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036027 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min CHEN (Boston, Massachusetts); Joshua FOSTER (Boston, Massachusetts); Minji KIM (Boston, Massachusetts); Matthew MOORE (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein is a composition that involves a nanopore disposed in a membrane preparation, wherein the nanopore has an outer membrane protein G (OmpG) having 8 to 22 β-strands connected by a plurality of flexible loops on a first side of the membrane preparation and a plurality short turns on a second side of the membrane preparation, wherein a heterologous peptide is inserted within one or more of the flexible loops. Also disclosed herein is a method of detecting binding of a ligand to a target, the method involving: exposing a nanopore composition disclosed herein to a target; assessing a gating pattern of the nanopore; and detecting binding of the target to the heterologous peptide based on the gating pattern. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/338855 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036035 | Walter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nils G. Walter (Ann Arbor, Michigan); Shankar Mandal (Ann Arbor, Michigan); Aaron T. Blanchard (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein is technology relating to detecting analytes and particularly, but not exclusively, to methods, compositions, systems, and kits for detecting analytes using fluorogenic probes and multiplex technologies. |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/351263 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) Original (OR) Class G01N 33/557 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240036042 — CLICK CHEMISTRY AMPLIFIED NANOPORE ASSAY FOR ULTRASENSITIVE QUANTIFICATION OF PROTEINS
| US 20240036042 | LIU |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHANG LIU (CHAPIN, South Carolina) |
| ABSTRACT | Methods disclosed herein are directed to methods of detecting and/or quantifying an antigen. The ultrasensitive Click chemistry Amplified Nanopore (CAN) assay has been engineered for antigen quantification in a biological sample. According to the present disclosure, the CAN assay is based on the combination of an amplified sandwich assay and nanopore sensing. Methods disclosed herein may be incorporated into a point-of-care test device with the necessary accuracy, portability, cost efficiency, and simplicity to fill the diagnostic gaps in high infectious disease burden areas. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363341 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5695 (20130101) G01N 33/54346 (20130101) G01N 33/56988 (20130101) Original (OR) Class G01N 2333/35 (20130101) G01N 2333/161 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036055 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingjun LI (Madison, Wisconsin); Miyang LI (Madison, Wisconsin); Min MA (Madison, Wisconsin) |
| ABSTRACT | The present invention provides improved cleavable biotin-containing isobaric tags for quantitative mass spectrometry proteomics, particularly useful in quantification of post-translational modifications (PTMs) and assessing cysteine containing proteins. The isobaric chemical tags, DiLeu-Biotin-Azide (DBA), consist of three “modules”: (1) a DiLeu reporter group for relative quantification using MS/MS; (2) a biotin moiety for selective enrichment via streptavidin beads; and (3) an azide functional group to enable biorthogonal click chemistry. The DBA tags could be used in a high-throughput quantitative pan-PTM analysis platform. |
| FILED | Wednesday, June 14, 2023 |
| APPL NO | 18/334781 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) Original (OR) Class G01N 2440/00 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036062 | Pennypacker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith R. Pennypacker (Lexington, Kentucky); Justin F. Fraser (Lexington, Kentucky); Christopher McLouth (Lexington, Kentucky); Jordan P. Harp (Lexington, Kentucky); Sarah Messmer (Lexington, Kentucky); Jacqueline A. Frank (Lexington, Kentucky) |
| ABSTRACT | Tools for identifying risk of and for treating vascular contributions to cognitive impairment and dementia (VCID) and stroke-induced cognitive impairment in a subject are provided and include a method and a device that involve detecting target proteins in systemic blood sample from the subject. |
| FILED | Thursday, July 27, 2023 |
| APPL NO | 18/227192 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/26 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2333/4745 (20130101) G01N 2800/52 (20130101) G01N 2800/2814 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036128 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xin Yu (Malden, Massachusetts); Yuanyuan Jiang (Malden, Massachusetts); David C. Hike (Somerville, Massachusetts); Bei Zhang (Malden, Massachusetts); Zeping Xie (Malden, Massachusetts) |
| ABSTRACT | A system for awake functional magnetic resonance imaging (fMRI) of an animal subject includes an RF coil apparatus and a tunnel apparatus. The RF coil apparatus includes an RF coil configured to be implanted on the animal subject, a head post coupled to the RF coil and comprising a housing and a circuit board positioned within the housing, and a connector coupled to the circuit board. The tunnel apparatus includes a first end having an opening, a second end, a slot positioned on a top side of the tunnel apparatus and configured to movably receive the head post of the RF coil apparatus, and an inner region configured to receive the animal subject and allow the animal subject to move from the first end to the second end. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363256 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/0205 (20130101) A61B 5/6868 (20130101) A61B 2503/40 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036135 | Jia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Xun Jia (Dallas, Texas); Ge Wang (Loudonville, New York); Mengzhou Li (Troy, New York); Weiwen Wu (Troy, New York); Wenxiang Cong (Albany, New York); Yuting Peng (Dallas, Texas); Jace Grandinetti (Dallas, Texas) |
| ABSTRACT | In one embodiment, there is provided a magnetic resonance (MR) subsystem for magnetic resonance imaging (MRI). The MR subsystem includes a first magnet-coil assembly and a second magnet-coil assembly. The first magnet-coil assembly includes a first magnet structure and a first gradient coil. The second magnet-coil assembly includes a second magnet structure and a second gradient coil. The first magnet-coil assembly and the second magnet-coil assembly are separated by a gap. The gap is configured to facilitate transmission of an x-ray beam from an x-ray source to an x-ray detector. The x-ray source and the x-ray detector are included in a computed tomography (CT) subsystem. |
| FILED | Monday, July 31, 2023 |
| APPL NO | 18/228064 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/385 (20130101) G01R 33/4812 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240038517 | HOLLAND et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa HOLLAND (Morgantown, West Virginia); Stephen J. VALENTINE (Morgantown, West Virginia); Peng LI (Morgantown, West Virginia) |
| ABSTRACT | A device may include a separation capillary having an injection end and a distal end, the injection end configured to receive analyte liquid and the distal end configured to expel the analyte liquid. A device may include a sheath capillary covering the distal end of the separation capillary, the sheath capillary having a diameter that is greater than an outer diameter of the separation capillary at the distal end, the sheath capillary having a first end and a second end, the distal end of the separation capillary positioned between the first end and the second end of the sheath capillary, the sheath capillary carrying a fluid between the second end and the first end. A device may include an acoustic probe configured to vibrate positioned in contact with the at least one of the distal end of the separation capillary or the first end of the sheath capillary. |
| FILED | Monday, July 31, 2023 |
| APPL NO | 18/228599 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039241 | Yun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seok-Hyun Yun (Belmont, Massachusetts); Paul Dannenberg (Cambridge, Massachusetts) |
| ABSTRACT | A first layer, a first spacer layer, and a second layer of a semiconductor wafer can be etched to produce a plurality of columnar structures extending from the substrate layer and including a first optical cavity situated about the first gain medium, a second optical cavity situated about the second gain medium, and a first spacer region contacting the first gain medium and the second gain medium. Also, a photonic microparticle formed from a layered semiconductor wafer and of a columnar structure having a first optical cavity situated about a first gain medium, a second optical cavity situated about a second gain medium, and a first spacer region contacting the first gain medium and the second gain medium. The first optical cavity and the second optical cavity in the photonic microparticle are each capable of generating laser light with a distinct spectral peak when energetically excited. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 18/044432 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0076 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/041 (20130101) H01S 5/0217 (20130101) H01S 5/1021 (20130101) Original (OR) Class H01S 5/1042 (20130101) H01S 5/1092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240033022 | Farritor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shane Farritor (Lincoln, Nebraska); Thomas Frederick (Gretna, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania); Eric Markvicka (Lincoln, Nebraska); Jack Mondry (Edina, Minnesota) |
| ABSTRACT | The various embodiments disclosed herein relate to improved robotic surgical systems, including robotic surgical devices having improved arm components and/or biometric sensors, contact detection systems for robotic surgical devices, gross positioning systems and devices for use in robotic surgical systems, and improved external controllers and consoles. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/482994 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/30 (20160201) Original (OR) Class A61B 2034/302 (20160201) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033037 | Reichenbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Reichenbach (Lincoln, Nebraska); Shane Farritor (Lincoln, Nebraska) |
| ABSTRACT | Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/482959 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00149 (20130101) A61B 17/0206 (20130101) A61B 34/30 (20160201) A61B 34/73 (20160201) A61B 90/50 (20160201) Original (OR) Class A61B 2017/00477 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033219 | Annabi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Massachusetts Eye and Ear Infirmary (Boston, Massachusetts); The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nasim Annabi (Los Angeles, California); Reza Dana (Waban, Massachusetts); Shima Gholizadeh (Los Angeles, California) |
| ABSTRACT | Disclosed herein are polymers, nanoparticles, and pharmaceutical compositions and formulations that are useful for topical delivery of therapeutic agents to an eye of an subject in need thereof. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 18/256277 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Original (OR) Class A61K 31/122 (20130101) A61K 31/215 (20130101) A61K 31/496 (20130101) A61K 47/32 (20130101) A61K 47/34 (20130101) A61K 47/183 (20130101) A61K 2121/00 (20130101) A61K 2800/41 (20130101) A61K 2800/95 (20130101) A61K 2800/5424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033739 | Ramsey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Michael Ramsey (Chapel Hill, North Carolina); William Hampton Henley (Chapel Hill, North Carolina) |
| ABSTRACT | A fluidic device includes a plurality of reaction wells, typically in a dense array, with at least one bead retention segment in fluid communication with and spatially separated from at least one signal detection segment. A respective bead retention segment can be configured to hold a single bead, which can have a reagent attached thereto. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/481295 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/00029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034047 | Kalfon-cohen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Metis Design Corporation (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Estelle Kalfon-cohen (Chestnut Hill, Massachusetts); Seth S. Kessler (Newton, Massachusetts) |
| ABSTRACT | A multiscale composite materials with few or no void defects are described. The composite materials include a network of porous materials. Methods and systems for the fabrication of the composite materials are generally described. According to certain embodiments, composite materials are fabricated without the use of an autoclave or low pressure environments. |
| FILED | Friday, August 11, 2023 |
| APPL NO | 18/233249 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/20 (20130101) B32B 5/02 (20130101) B32B 7/03 (20190101) B32B 7/12 (20130101) B32B 37/06 (20130101) B32B 37/18 (20130101) Original (OR) Class B32B 2262/0261 (20130101) B32B 2305/22 (20130101) B32B 2305/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034686 | Silverstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ravit Silverstein (Golea, California); Frank W. Zok (Goleta, California); Carlos G. Levi (Santa Barbara, California) |
| ABSTRACT | A two-step synthesis of SiC including initial exposure of carbon surfaces to Si vapor, followed by Si melt infiltration, is described herein. Interrupted differential thermal analysis (DTA) of amorphous C and Si powder mixtures and microstructure characterization are used to identify the stages of the reaction. Exposure to Si vapor yields a SiC layer with nanoscale porosity driven by the volume change associated with the reaction. This forms a continuous pore network that promotes subsequent melt access to the reaction front with the C. While the pores remain open, the vapor phase reaction proceeds at a nearly-constant rate and exhibits a strong temperature sensitivity, the latter due largely to the temperature sensitivity of the Si vapor pressure. The implications for enhancing the reactive melt infiltration process and fabrication of SiC matrices for ceramic composites are discussed. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 18/258148 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/65 (20130101) C04B 35/80 (20130101) Original (OR) Class C04B 35/657 (20130101) C04B 35/62863 (20130101) C04B 35/62884 (20130101) C04B 35/62886 (20130101) C04B 2235/78 (20130101) C04B 2235/422 (20130101) C04B 2235/614 (20130101) C04B 2235/616 (20130101) C04B 2235/3826 (20130101) C04B 2235/5244 (20130101) C04B 2235/5248 (20130101) C04B 2235/5252 (20130101) C04B 2235/6567 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034775 | Paz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads (San Francisco, California); Annexon, Inc. (Brisbane, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeanne T. Paz (San Francisco, California); Sethu Sankaranarayanan (Fremont, California); Ted Yednock (Forest Knolls, California) |
| ABSTRACT | The present disclosure relates generally to methods of preventing, reducing risk of developing, or treating epilepsy, comprising administering to a subject an inhibitor of the classical complement pathway. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/923456 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/4716 (20130101) G01N 2800/2857 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034910 | Kho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong An Kho (San Diego, California); Steven Mancewicz (San Diego, California) |
| ABSTRACT | An assembly process using liquid optically clear adhesive for support of thin components. The method comprising the steps of placing a release liner and substrate, determining the placement location of the embedding material, positioning the embedding material on the determined placement location, applying a first LOCA, sandwiching the embedding material between the contact side of the substrate and the release side of the release liner to create an initial assembly, curing the first LOCA, removing the release liner, securing the substrate onto a cutting mat with the embedding material and first LOCA facing up, cutting a detailed design, transferring the initial assembly to the work surface, removing unwanted embedding material, applying a second LOCA, sandwiching the detailed design, curing the second LOCA, cleaning the final assembly, and trimming the edges of the final assembly to the size and shape of a final product. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/875145 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 5/04 (20130101) Original (OR) Class C09J 7/20 (20180101) C09J 7/403 (20180101) C09J 2301/208 (20200801) C09J 2301/416 (20200801) C09J 2301/502 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034915 | Cooper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher B. Cooper (Palo Alto, California); Zhenan Bao (Stanford, California); Tomoko Nogusa (Yokohama, Japan) |
| ABSTRACT | Underwater adhesive are provided that include a hydrophobic polymer backbone having periodically embedded dynamic bonding units, where the underwater adhesive has nanophase separation between a first phase of the hydrophobic polymer backbone and a second phase of the dynamic bonding units. The resulting nanophase-separated morphology has clusters of dynamically bonded groups that are protected from water by a surrounding matrix of hydrophobic polymer backbone. This enables a pressure sensitive underwater adhesive with advantages of: no curing needed, reusable, recyclable, and good adhesion strength. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/227826 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/387 (20180101) Original (OR) Class C09J 2203/37 (20200801) C09J 2301/302 (20200801) C09J 2409/00 (20130101) C09J 2471/00 (20130101) C09J 2483/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035014 | Stephanopoulos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nicholas Stephanopoulos (Scottsdale, Arizona); Yang Xu (Chandler, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Nicholas Stephanopoulos (Scottsdale, Arizona); Yang Xu (Chandler, Arizona) |
| ABSTRACT | Described herein are polyhedral, three-dimensional tunable nanocages assembled with a multimeric protein covalently linked to a polynucleotide handle and a DNA origami base assembly including sequences complementary to the polynucleotide handles, wherein the polynucleotide handle and the complementary sequences hybridize to for double-stranded DNA helices. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485895 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Original (OR) Class C12N 15/11 (20130101) Enzymes C12Y 401/02014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035021 | Weinberger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The J. David Gladstone Institutes (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leor S. Weinberger (Oakland, California); Timothy J. Notton (San Francisco, California) |
| ABSTRACT | Provided are methods and compositions for generating a deletion library, and methods and compositions for generating and identifying a defective interfering particle (DIP). Also provided are transposon cassettes. A subject method can include: inserting a transposon cassette comprising a target sequence for a sequence specific DNA endonuclease into a population of circular target DNAs to generate a population of transposon-inserted circular target DNAs; contacting the population of transposon-inserted circular target DNAs with the sequence specific DNA endonuclease to generate a population of cleaved linear target DNAs; contacting the population of cleaved linear target DNAs with one or more exonucleases to generate a population of deletion DNAs; and circularizing the deletion DNAs to generate a library of circularized deletion DNAs. The population of circular target DNAs can include viral genomic DNA. Also provided ae human immunodeficiency virus (HIV) deletion mutants, e.g., interfering, conditionally replicating, HIV deletion mutants, and related constructs. |
| FILED | Monday, February 20, 2023 |
| APPL NO | 18/171578 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/66 (20130101) C12N 15/867 (20130101) C12N 15/1065 (20130101) C12N 15/1082 (20130101) Original (OR) Class C12N 2310/533 (20130101) C12N 2800/80 (20130101) C12N 2800/90 (20130101) C12N 2800/107 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 2563/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035052 | Lynch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods for rapid production of chemicals in genetically engineered microorganisms in a large scale. Also provided herein is a high-throughput metabolic engineering platform enabling the rapid optimization of microbial production strains. The platform, which bridges a gap between current in vivo and in vitro bio-production approaches, relies on dynamic minimization of the active metabolic network. |
| FILED | Monday, May 15, 2023 |
| APPL NO | 18/317588 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/0016 (20130101) C12N 9/0051 (20130101) C12N 9/1025 (20130101) C12N 15/746 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class C12P 13/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035060 | Sun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SYNVITROBIO, INC. (San Leandro, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary Z. Sun (San Leandro, California); Richard Mansfield (San Leandro, California); Abel C. Chiao (San Leandro, California); Kelly S. Trego (San Leandro, California) |
| ABSTRACT | Provided herein, in one aspect, is a composition for in vitro transcription and translation, comprising: a treated cell lysate derived from one or more organisms such as bacteria, archaea, plant or animal; a plurality of supplements for gene expression; an energy recycling system for providing adenosine triphosphate and recycling adenosine diphosphate; and an engineered propeptide operably linked to a stabilizing domain. Methods for making and using the same are also provided. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311555 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) C12P 21/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035068 | Samusik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolay Samusik (Mountain View, California); Garry P. Nolan (Redwood City, California); Yury Goltsev (Stanford, California); David Robert McIlwain (Palo Alto, California) |
| ABSTRACT | A method for analyzing planar sample is provided. In some cases the method comprises: (a) labelling the planar sample with a capture agent that is linked to a nucleic acid, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the nucleic acid, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177750 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6818 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035558 | Falls et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan W. Falls (Arlington, Texas); Charles H. Speller (Oak Point, Texas) |
| ABSTRACT | Breathing systems and methods for a gearbox is described. Embodiments preferably create a closed system for air within the gearbox. As an operating gearbox warms the air or fluid within, or an altitude change causes air to expand or contract, increased pressure can result and air can escape through tubing to a cannister. The cannister can receive the expanding air in an impermeable cavity that is proximate to a bladder open or partially open to an exterior environment. Air can press on the bladder, expanding the cavity and shrinking the bladder until a pressure equilibrium is reached. As operation of the gearbox is lowered or powered off, or another altitude change occurs, the air can cool and/or retract into the gearbox. The bladder can then expand and press on the cavity until equalizing the pressure within the cannister. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877629 |
| CURRENT CPC | Gearing F16H 57/027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036045 | Cohen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Evan Laurence Busch (Somerville, Massachusetts); The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Limor Cohen (Boston, Massachusetts); David R. Walt (Boston, Massachusetts); Evan Laurence Busch (Somerville, Massachusetts) |
| ABSTRACT | Methods and compositions for accurate blood biomarker panel-based detection of cancer, e.g., breast cancer, and sub-typing, e.g., using ultrasensitive immunoassays, e.g., digital ELISA. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 18/268034 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class G01N 2800/50 (20130101) G01N 2800/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036259 | Pruessner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcel W. Pruessner (Washington, District of Columbia); Todd H. Stievater (Arlington, Virginia); Nathan F. Tyndall (Alexandria, Virginia) |
| ABSTRACT | An apparatus includes a polarization rotator or a polarization splitter. The polarization rotator and the polarization splitter each includes a first optical waveguide. The polarization rotator further includes a movable symmetry-breaking micro-electro-mechanical systems (“MEMS”) dielectric perturber separated from the first optical waveguide by a gap. The first optical waveguide and the MEMS dielectric perturber define a gap therebetween. The polarization rotator also includes a MEMS actuator moving the MEMS dielectric perturber so as to control the gap, thereby controlling polarization rotation within the first optical waveguide. The polarization splitter includes a second optical waveguide separated from the first optical waveguide by a gap. The polarization splitter also includes a MEMS actuator moving the first optical waveguide and/or the second optical waveguide so as to control the gap, thereby controlling polarization splitting between the optical waveguides. |
| FILED | Friday, July 14, 2023 |
| APPL NO | 18/221962 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/126 (20130101) G02B 6/2766 (20130101) Original (OR) Class G02B 6/3584 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036295 | Laxton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Benjamin Laxton (San Diego, California); Kyle Drexler (San Diego, California); Skylar D. Lilledahl (El Cajon, California) |
| ABSTRACT | A digital adaptive optics encoder module includes an input mounting flange, a collimating lens, a bandpass filter, digital adaptive optic elements, refocusing lens, an output mounting flange, and a housing. The input mounting flange is capable of attaching to a telescope. The collimating lens is capable of expanding light from a target to fill a plurality of primary apertures. The bandpass filter has a bandwidth ranging from about 40 nm to about 100 nm. The digital adaptive optic elements include the plurality of primary apertures, an optical spreader, a focusing optic, and a detector. The refocusing lens is capable of refocusing an output from the digital adaptive optic elements onto a sensor plane. The output mounting flange is capable of attaching to an output connection. The housing encloses all of the interior components of the digital adaptive optics encoder module. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/873333 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/34794 (20210501) Optical Elements, Systems, or Apparatus G02B 13/02 (20130101) Original (OR) Class G02B 23/16 (20130101) G02B 23/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240037786 | Bramlett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Science Applications International Corporation (Reston, Virginia) |
| ASSIGNEE(S) | Science Applications International Corporation (Reston, Virginia) |
| INVENTOR(S) | Stephen Eric Bramlett (Gurley, Alabama); Michael Harris Rodgers (Huntsville, Alabama) |
| ABSTRACT | Search points in a search space may be projected onto images from cameras imaging different parts of the search space. Subimages, corresponding to the projected search points, may be selected and processed to determine if a target object has been detected. Based on subimages in which target objects are detected, as well as orientation data from cameras capturing images from which the subimages were selected, positions of the target objects in the search space may be determined. |
| FILED | Thursday, August 24, 2023 |
| APPL NO | 18/237481 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4038 (20130101) G06T 7/33 (20170101) G06T 7/70 (20170101) G06T 7/74 (20170101) Original (OR) Class G06T 7/80 (20170101) G06T 7/174 (20170101) G06T 7/246 (20170101) G06T 2207/10016 (20130101) G06T 2207/20021 (20130101) G06T 2207/20068 (20130101) G06T 2207/30212 (20130101) G06T 2207/30232 (20130101) G06T 2207/30244 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/255 (20220101) G06V 10/462 (20220101) G06V 10/751 (20220101) G06V 20/52 (20220101) G06V 20/60 (20220101) G06V 2201/07 (20220101) Pictorial Communication, e.g Television H04N 23/80 (20230101) H04N 23/90 (20230101) H04N 23/695 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240037909 | Tong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kun Tong (West Hartford, Connecticut); Tracy A. Propheter-Hinckley (Rocky Hill, Connecticut); Venumadhava Ponnala (East Hampton, Connecticut); Andres Diaz Alvarado (Humacao, Puerto Rico) |
| ABSTRACT | An example method for vane classification includes scanning, using a structured light scanner, a vane for a turbine engine to capture three-dimensional (3D) data about the vane. The method further includes generating a point cloud from the 3D data about the vane. The method further includes connecting, using a processing system, points of the point cloud to generate a mesh surface. The method further includes determining, using the processing system, an airflow for an airfoil of the vane based at least in part on the mesh surface. The method further includes constructing the turbine engine based at least in part on the airflow for the airfoil of the vane without reference to an adjacent airfoil of the vane. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877712 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/02 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2240/12 (20130101) F05D 2250/20 (20130101) Image Data Processing or Generation, in General G06T 7/521 (20170101) G06T 17/20 (20130101) G06T 2207/10028 (20130101) G06T 2207/30164 (20130101) Image or Video Recognition or Understanding G06V 10/764 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240038523 | Cooks |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for conducting reactions and screening for reaction products. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/378247 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0013 (20130101) H01J 49/165 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039034 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies, Inc. (Alameda, California); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Feixiang WU (Atlanta, Georgia); Hyea KIM (Atlanta, Georgia) |
| ABSTRACT | Lithium-ion batteries are provided that variously comprise anode and cathode electrodes, an electrolyte, a separator, and, in some designs, a protective layer. In some designs, at least one of the electrodes may comprise a composite of (i) Li2S and (ii) conductive carbon that is embedded in the core of the composite. In some designs, the protective layer may be disposed on at least one of the electrodes via electrolyte decomposition. Various methods of fabrication for lithium-ion battery electrodes and particles are also provided. |
| FILED | Tuesday, May 16, 2023 |
| APPL NO | 18/318519 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/136 (20130101) H01M 4/366 (20130101) H01M 4/0404 (20130101) H01M 4/0428 (20130101) H01M 4/0471 (20130101) H01M 4/1397 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) Original (OR) Class H01M 10/0568 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101) Technical Subjects Covered by Former US Classification Y10T 156/10 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039077 | NEMANICK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Eric Joseph NEMANICK (Santa Monica, California); Henry HELVAJIAN (Pasadena, California); Adon DELGADO, JR. (West Hills, California); Kristine L. FERRONE (Pasadena, Texas) |
| ABSTRACT | Energy storage radiators are disclosed. The structure of the radiator may be used as a battery to store and release energy, as well as serving to regulate the temperature of that battery and the associated device or vehicle. The structure may be configured to provide mechanical support, an enclosure, an attachment point, or an extension for a vehicle or a device. By designing an energy storage radiator to function as a battery, a separate battery superstructure may not be required. Also, the heat to be radiated away can be used to keep the battery in its operating temperature range. This may provide mass reduction of the radiator structures or materials, as well as make those materials multifunctional and replace material elsewhere with respect to conventional systems. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/815707 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/425 (20130101) B64G 1/443 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/465 (20130101) H01M 10/617 (20150401) H01M 10/625 (20150401) H01M 10/6551 (20150401) Original (OR) Class H01M 2220/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039318 | Muller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nia Therapeutics, Inc. (Radnor, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rikky Muller (San Francisco, California); Benjamin Johnson (Boise, Idaho); Igor Izyumin (Oakland, California) |
| ABSTRACT | Representative methods, apparatus and systems are disclosed for providing concurrent electrical stimulation and electrical recording in a human or non-human subject, such as for neuromodulation, with the apparatus coupleable to an electrode array. A representative apparatus is typically an integrated circuit including: stimulation circuits, recording circuits, and blocking circuits responsive to control signals to block the stimulation voltage or current on an electrode from a corresponding recording circuit, while other recording circuits may simultaneously record electrical signals from other electrodes and generate recorded data. A representative stimulation circuit may include current sources; a first multiplexer for current source selection; a second multiplexer for electrode selection; a switchable voltage offset circuit; a switchable grounding circuit; and a stimulation controller providing control signals to provide the electrical stimulation, such as biphasic or monophasic stimulation, and bipolar or unipolar stimulation. Off-chip communication, control, along with power and voltage level control, are also provided. |
| FILED | Saturday, October 14, 2023 |
| APPL NO | 18/380166 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/291 (20210101) A61B 5/293 (20210101) A61B 5/4094 (20130101) A61B 5/4836 (20130101) A61B 5/6868 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36125 (20130101) A61N 1/36139 (20130101) A61N 1/36157 (20130101) A61N 1/36167 (20130101) A61N 1/37223 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 1/082 (20200101) H02J 7/00 (20130101) H02J 7/0063 (20130101) Original (OR) Class H02J 50/20 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039563 | Steenson, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | James H. Steenson, JR. (Hudson, New Hampshire); Joseph P. Cullen (Chelmsford, Massachusetts) |
| ABSTRACT | Techniques to dynamically adjust the corner frequency of a high-pass filter in response to a time-domain amplitude value of an output signal, thereby preserving accuracy while promptly recovering the signal's baseline value. A system can be configured to filter frequency-domain values of an input signal based on a filtering characteristic. The filtering characteristic can be set dynamically in response to a time-domain value of an amplitude of an output signal. The filtering characteristic can comprise a corner frequency, and the system can include a high-pass filter configured to filter out frequency components at frequencies lower than the corner frequency. The system is configured to dynamically change the corner frequency from a first value to a second value, in response to the time-domain value of the amplitude crossing a threshold value. The system may dynamically change the corner frequency within a time interval after the crossing. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/815164 |
| CURRENT CPC | Transmission H04B 1/001 (20130101) Original (OR) Class H04B 1/0014 (20130101) H04B 1/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039941 | Kang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuan Jochen Kang (New York, New York); Salvatore Stolfo (New York, New York) |
| ABSTRACT | Mechanisms for defending a computing system from attack are provided. The mechanisms include: maintaining a round counter that tracks a round number for a local host; determining a location in a graph for each of a plurality of hosts including the local host; determining monitor hosts of the plurality of hosts that are monitoring the local host; determining monitoree hosts of the plurality of hosts that are being monitored by the local host; sending a message to each of the monitor hosts identifying a value of the round counter; forwarding a first set of heartbeat messages from previous monitoree hosts to the monitor hosts; attempting to receive messages from the monitoree hosts; determining whether any messages were not received from the monitoree hosts; and in response to determining that one or more messages were not received from the monitoree hosts, generating an alert. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/378002 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/582 (20130101) G06F 9/542 (20130101) G06F 21/54 (20130101) G06F 21/602 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1425 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240033362 | Negrete et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oscar Negrete (Livermore, California); Annette Estelle LaBauve (Hayward, California); Joseph S. Schoeniger (Oakland, California); Edwin A. Saada (Dublin, California) |
| ABSTRACT | A construct includes a core comprising an external surface and a plurality of pores, a cargo disposed in a pore of the plurality of pores, the cargo comprising a CRISPR Cas9 component or a nucleic acid sequence encoding a CRISPR Cas9 component; and a coating coupled to the core, wherein the coating comprises a cationic lipid, a pegylated lipid, a zwitterionic lipid, and a sterol. The coating may comprise a molar ratio of about 1 cationic lipid to 1 zwitterionic lipid to 0.9 sterol to 0.15 PEGylated lipid, wherein each molar ratio optionally varies by about plus or minus 10%. A method of treatment is also provided. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/874818 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/10 (20130101) A61K 47/543 (20170801) Original (OR) Class A61K 47/6923 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033720 | Fornasiero et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francesco Fornasiero (Oakland, California); Edmond Y. Lau (Dublin, California); Carlos A. Valdez (San Ramon, California) |
| ABSTRACT | A method of forming a chemically reactive membrane includes applying a first solution to a structure, the first solution includes a macrocyclic ligand having electron-donating ligands and a side functional group for crosslinking, crosslinking a plurality of the macrocyclic ligand to form a first network of crosslinked macrocyclic ligands, and applying a second solution to the structure, the second solution comprising a catalytic center. Each catalytic center complexes with the electron-donating ligands of each macrocyclic ligand to form catalytic sites in the first network of crosslinked macrocyclic ligands. |
| FILED | Wednesday, August 23, 2023 |
| APPL NO | 18/237326 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 35/065 (20130101) Original (OR) Class B01J 35/1061 (20130101) B01J 35/1066 (20130101) B01J 35/1071 (20130101) B01J 35/1076 (20130101) B01J 37/0215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033967 | Kenny et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher James Kenny (Schoharie, New York); Collin McKee Sheppard (Greenville, South Carolina); Xiaopeng Li (Niskayuna, New York); Norman Arnold Turnquist (Carlisle, New York) |
| ABSTRACT | The present application presents novel systems and methods for tracking reinforcement member placement in an additively manufactured structure that are simple, accurate, non-labor-intensive, and cost-effective. The present application also presents a novel method of manufacturing a tower structure comprising: depositing, via an additive printing system, a first printed layer of a wall with a printhead assembly, the wall at least partially circumscribing a vertical axis of the tower structure; positioning a first reinforcement member on the first printed layer; depositing, via the additive printing system, a second printed layer of the wall with the printhead assembly on the first reinforcement member, the second printed layer configured to hold a second reinforcement member thereon; and determining, via an optical sensor of the additive printing system, a position for placing the second reinforcement member based on the first reinforcement member positioning. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/873733 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Original (OR) Class B28B 17/0081 (20130101) B28B 21/56 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033994 | CRATON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Michael Thomas CRATON (Lansing, Michigan); Ioannis PAPAPOLYMEROU (Okemos, Michigan); Premjeet CHAHAL (Okemos, Michigan); John D. ALBRECHT (Okemos, Michigan) |
| ABSTRACT | Material mixing for an additive manufacturing apparatus is provided. A further aspect employs multiple material inlets for simultaneously feeding a polymer and/or nanocomposite material in at least a first inlet, and ceramic or other particles in at least a second inlet, to a single additive manufacturing outlet nozzle. In another aspect, a three dimensional printing machine varies a chemical or compounding characteristic, such as a loading percentage, of printing material during printing. In another aspect, in situ mixing of a polymer and/or nanocomposite with variable amounts of ceramic, magnetic or other particles therein in an additive manufacturing apparatus, such as a multi-material aerosol jet printing machine. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/378218 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) B29C 64/314 (20170801) Original (OR) Class B29C 64/393 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/3425 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 50/02 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034687 | CAHILL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JAMES TIMOTHY CAHILL (Livermore, California); QI RONG YANG (Pleasanton, California) |
| ABSTRACT | A shape-stable structure that is configured to provide ablative cooling. The structure is used to form a component that includes shape-stable bulk structure and an ablative material. The bulk structure is infiltrated with the ablative material so that the ablative material is disposed in pathways defined by the bulk structure. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878808 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/48 (20130101) C04B 38/0093 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034837 | Foster et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey C. Foster (Albuquerque, New Mexico); Erica M. Redline (Albuquerque, New Mexico); Chad L. Staiger (Albuquerque, New Mexico); Koushik Ghosh (Albuquerque, New Mexico); Eric M. Nagel (Albuquerque, New Mexico) |
| ABSTRACT | Linear polymers and copolymers having tunable coefficients of thermal expansion can be derived from dibenzocyclooctene-based monomers. The dibenzocyclooctene-based monomer can comprise a dibenzocyclooctene or a heterocyclic derivative of dibenzocyclooctene. For example, the linear polymer can comprise a polymer or copolymer of a dibenzocyclooctene-based moiety and a polyester, polyamide, polyimide, polyurethane, or epoxy. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/101629 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/199 (20130101) C08G 69/26 (20130101) C08G 73/0694 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034883 | Mass et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Boise State University (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Olga A. Mass (Boise, Idaho); William B. Knowlton (Boise, Idaho) |
| ABSTRACT | Dye aggregates that are templated to deoxyribonucleic acid (DNA) can exhibit different packing arrangements and, as an optically active medium, spectral properties of interest. Steric effects and properties of the linker that tethers the dye to a DNA scaffold (a simple nucleotide oligomer or more complex architectures) can used to fine tune the packing arrangement of the dyes to obtain desirable spectral properties. To gain access to J-aggregates (head-to-tail packing arrangement) as a source of fluorescent materials, the present disclosure is directed to two strategies that utilize rigid linkers to promote J-packing. Devices and methods of use also are disclosed herein. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/361055 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 47/00 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034937 | NARULA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Chaitanya K. NARULA (Knoxville, Tennessee); Brian H. DAVISON (Knoxville, Tennessee); Martin KELLER (Knoxville, Tennessee) |
| ABSTRACT | A method for converting an alcohol to a hydrocarbon, the method comprising contacting said alcohol with a metal-loaded zeolite catalyst at a temperature of at least 100° C. and up to 550° C., wherein said alcohol can be produced by a fermentation process, said metal is a positively-charged metal ion, and said metal-loaded zeolite catalyst is catalytically active for converting said alcohol to said hydrocarbon. |
| FILED | Tuesday, August 22, 2023 |
| APPL NO | 18/236717 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 29/46 (20130101) B01J 29/48 (20130101) B01J 29/061 (20130101) B01J 29/072 (20130101) B01J 29/076 (20130101) B01J 29/143 (20130101) B01J 35/04 (20130101) B01J 35/023 (20130101) B01J 37/0246 (20130101) Acyclic or Carbocyclic Compounds C07C 1/22 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 3/45 (20130101) C10G 3/49 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/06 (20130101) C12P 7/08 (20130101) C12P 7/10 (20130101) C12P 7/16 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 30/20 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035502 | Lim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Chae Lim (Oak Ridge, Tennessee); Ji Heon Jun (Oak Ridge, Tennessee); Michael P. Brady (Oak Ridge, Tennessee); Zhili Feng (Oak Ridge, Tennessee) |
| ABSTRACT | A fastener for use in joining dissimilar materials manufactured by the process of producing the fastener with an external surface that forms an electrically insulating oxide layer when subjected to oxidation and, after manufacture and prior to use, subjecting the fastener to a pre-oxidation process to grow the desired oxide layer in situ on the external surface of the fastener. The present invention also provides a dissimilar material joint in which the pre-oxidized fastener is used to mechanically join dissimilar materials with the oxide layer electrically insulating the fastener from at least one of the dissimilar materials. The fastener may be a rivet used in friction self-piercing riveting (F-SPR). The fastener may be fabricated from an alloy capable of forming Al2O3 or Cr2O3 by thermal oxidation. The fastener may be pre-coated with Al or Cr that functions as a seed layer to form Al2O3 or Cr2O3. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/376209 |
| CURRENT CPC | Alloys C22C 38/002 (20130101) C22C 38/02 (20130101) C22C 38/005 (20130101) C22C 38/06 (20130101) C22C 38/42 (20130101) C22C 38/44 (20130101) C22C 38/46 (20130101) C22C 38/50 (20130101) C22C 38/54 (20130101) C22C 38/58 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 8/14 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 5/04 (20130101) Original (OR) Class F16B 19/086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036005 | Lal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEEGAH LLC (Ithaca, New York) |
| ASSIGNEE(S) | GEEGAH LLC (Ithaca, New York) |
| INVENTOR(S) | Amit Lal (Ithaca, New York); Justin Kuo (Ithaca, New York) |
| ABSTRACT | There is a need for miniature, low power, and remotely powered sensors that can measure moisture and reactive gas content in the environment. Examples of devices that already exist include dew-point sensors, moisture sensors, and oxygen sensors. This disclosure describes the use of high-frequency ultrasonic pulses to interrogate thin films on the imaging surface of a CMOS integrated GHz Ultrasonic imager substrate. In one embodiment the device uses a Peltier cooler and heater chip to detect the dew point by the act of moisture condensing on the surface. Integrated temperature measurement is enabled by using some of the pixels, isolated from the environment, to be reflectors that measure the phase change in the reflected signal due to the change in the speed of sound in the silicon substrate. In another embodiment a thin film is exposed to gases, changing its ultrasonic impedance, which can be used to extract the film thickness and its ultrasonic properties. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 18/266101 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/036 (20130101) Original (OR) Class G01N 29/348 (20130101) G01N 2291/0253 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/38 (20130101) Electric solid-state devices not otherwise provided for H10N 39/00 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036434 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | XINYI XU (New York, New York); CHIARA TROVATELLO (New York, New York); FABIAN MOOSHAMMER (New York, New York); YINMING SHAO (New York, New York); SHUVAIT ZHANG (New York, New York); KAIYUAN YAO (New York, New York); DMITRI N. BASOV (New York, New York); GIULIO CERULLO (Milan, Italy); P. JAMES SCHUCK (New York, New York) |
| ABSTRACT | Exemplary method and configuration for a frequency conversion can be provided. For example, such method and configuration can use at least one transition metal dichalcogenide (TDM) crystal (which can include one or more MoS2 crystals, which can be stacked). For example, it is possible to providing at least one radiation to the at least one TDM crystal so as to generate a resultant radiation. Resultant information can be generated by measuring difference frequency and a second harmonic generation (SHG) from the resultant radiation provided from the TDM crystal. The frequency conversion can be obtained or achieved by providing a measurement of a SHG coherence length based on the resultant information. |
| FILED | Thursday, July 27, 2023 |
| APPL NO | 18/227249 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/353 (20130101) G02F 1/3551 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240037774 | Gregorich |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Edward Gregorich (Bishop, California) |
| ABSTRACT | A technique for determining the three-dimensional position of radiation interaction in a scintillator is disclosed. The method comprises detecting a scintillation event within a scintillator to produce a measured detector response, by using a photodetector that has a planar surface optically coupled to the scintillator and that has a plurality of pixels defined on the planar surface. The method further comprises calculating a spatial distribution of photons, resulting from the scintillation event, across the planar surface of the detector, and determining an angle-dependent quantum efficiency of the photodetector, associated with the scintillation event. The method further comprises calculating a detector response of the photodetector based on the spatial distribution of photons and the angle-dependent quantum efficiency, to produce a calculated detector response; and computing a position in three dimensions of the scintillation event based on the calculated detector response and the measured detector response. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877497 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/204 (20130101) G01T 1/2018 (20130101) G01T 1/2928 (20130101) Original (OR) Class G01T 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240038096 | Sternberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRIAD National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Matthew Sternberg (Los Alamos, New Mexico); George Andrew Erickson (Los Alamos, New Mexico) |
| ABSTRACT | A system includes a container filled with material other than radioactive material. The system also includes a capacitor disposed on the container. The capacitor is disposed over a surface of the container. A power source, e.g., 5 V, is used for powering the capacitor that is connected to the power source through a resistor ranging between 20 and 40 mega ohms. A processor is used and configured to generate a feedback based on a measured charging/discharging associated with the capacitor as a user moves with respect to the container. In one nonlimiting example, the processor is configured to generate a rolling average of the charging/discharging. An output device of the system may be configured to render feedback to the user based on the proximity of the user with respect to the container. In some nonlimiting examples, the output device is configured to render the feedback based on the rolling average. |
| FILED | Monday, July 17, 2023 |
| APPL NO | 18/222878 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/04 (20130101) G09B 23/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240038428 | Tapadia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nidhishri Tapadia (Arvada, Colorado); David Allan Torrey (Ballston Spa, New York) |
| ABSTRACT | An electrical generator and method for operating the same are provided. Accordingly, the generator includes a non-rotatable component supporting a field winding assembly and a rotatable component oriented to rotate relative thereto. The generator also includes an armature winding assembly fixedly coupled to the rotatable component so as to rotate therewith during operation of the generator. The generator also includes a resistive assembly fixedly coupled to the rotatable component so as to rotate therewith during the operation of the generator. The resistive assembly electrically couples at least two separate phase windings of the armature winding assembly. The resistive assembly is also configured to introduce a resistance into the armature winding assembly in response to an electrical fault. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 18/550556 |
| CURRENT CPC | Wind Motors F03D 9/255 (20170201) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/06 (20130101) Original (OR) Class Dynamo-electric Machines H02K 7/1838 (20130101) H02K 9/20 (20130101) H02K 55/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240038836 | Hitchcock et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Collin William Hitchcock (Clifton Park, New York); Reza Ghandi (Cohoes, New York) |
| ABSTRACT | A semiconductor device includes a first epitaxial (epi) layer that forms a first super-junction (SJ) layer of the semiconductor device and a second epi layer disposed on the first SJ layer that forms a device layer of the semiconductor device. The first epi layer includes oppositely doped SJ pillars that extend along a first direction within the SJ layer. The device layer includes device structures of a striped metal-oxide-semiconductor field-effect transistor (MOSFET) device cell that extends along a second direction within the device layer. The angle between the first direction and the second direction is substantially between forty-five degrees and ninety degrees, inclusive. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878655 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/266 (20130101) H01L 29/0634 (20130101) Original (OR) Class H01L 29/0696 (20130101) H01L 29/1608 (20130101) H01L 29/7813 (20130101) H01L 29/66712 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240038918 | STEINER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Myles Aaron STEINER (Denver, Colorado); Daniel Joseph FRIEDMAN (Lakewood, Colorado); Ryan Matthew FRANCE (Golden, Colorado); Asegun HENRY (Boston, Massachusetts) |
| ABSTRACT | The present disclosure relates to a photovoltaic (PV) device that includes a first junction constructed with a first alloy and having a bandgap between about 1.0 eV and about 1.5 eV, and a second junction constructed with a second alloy and having a bandgap between about 0.9 eV and about 1.3 eV, where the first alloy includes III-V elements, the second alloy includes III-V elements, and the PV device is configured to operate in a thermophotovoltaic system having an operating temperature between about 1500° C. and about 3000° C. |
| FILED | Wednesday, August 23, 2023 |
| APPL NO | 18/454171 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0725 (20130101) H01L 31/0735 (20130101) Original (OR) Class H01L 31/1892 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/30 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039008 | LUO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | YUEFENG LUO (NORTH AUGUSTA, South Carolina); CHARLES JAMES, II (NORTH AUGUSTA, South Carolina); PRABHU GANESAN (AIKEN, South Carolina) |
| ABSTRACT | In one aspect, a method for manufacturing a battery includes forming a battery cell relative to a substrate using a layer-deposition sub-process, with the layer-deposition sub-process including: depositing a layer of first electrode material relative to the substrate; depositing a first layer of electrolyte material on top of the layer of first electrode material; depositing a layer of second electrode material on top of the first layer of electrolyte material; and depositing a second layer of electrolyte material on top of the layer of second electrode material. Additionally, the method includes cycling through the layer-deposition sub-process one or more additional times to form one or more additional battery cells relative to the substrate, with each additional battery cell being formed on top of a previously formed battery cell such that a battery cell stack is created relative to the substrate. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877397 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0414 (20130101) H01M 6/40 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0585 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039035 | Hood |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Zachary David Hood (Bolingbrook, Illinois) |
| ABSTRACT | A polymer-ceramic composite membrane and methods of making the same. The composite membrane includes a polymer scaffold and a ceramic nanoparticle disposed within the polymer scaffold. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877623 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/056 (20130101) Original (OR) Class H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039037 | YUN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SK On Co., Ltd. (Seoul, South Korea); Polyplus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Nyeong YUN (Daejeon, South Korea); Doehee PARK (Daejeon, South Korea); Eunjeong YI (Daejeon, South Korea); Cholho LEE (Daejeon, South Korea); Jaechan RYU (Daejeon, South Korea); Han Sol LEE (Daejeon, South Korea); Bruce Katz (Berkeley, California); Eugene Nimon (Berkeley, California); Steve J. Visco (Berkeley, California) |
| ABSTRACT | A negative electrode-glass electrolyte layer laminate including a negative electrode and a glass electrolyte layer on at least one surface of the negative electrode, wherein the negative electrode includes a surface passivated lithium-containing metal foil, and the laminate electrochemically operable in the absence of external pressure, an all-solid-state secondary battery including the negative electrode-glass electrolyte layer laminate, and a method of manufacturing the negative electrode-glass electrolyte layer laminate. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876202 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 10/0585 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039288 | Chinthavali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Madhu Sudhan Chinthavali (Oak Ridge, Tennessee); Michael Starke (Oak Ridge, Tennessee); Radha Krishna Moorthy (Oak Ridge, Tennessee); Steven Campbell (Oak Ridge, Tennessee) |
| ABSTRACT | A hierarchical approach is provided to integrate functions and components into the various systems and subsystems within a distribution network, including standardization of modular and scalable power electronics power blocks with embedded diagnostics and prognostics. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 17/989373 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 1/14 (20130101) H02J 1/084 (20200101) H02J 3/16 (20130101) Original (OR) Class H02J 3/381 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039836 | Roweth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Spring, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan Roweth (Bristol, United Kingdom); Edwin L. Froese (Burnaby, Canada); Joseph G. Kopnick (Chippewa Falls, Wisconsin); Andrew S. Kopser (Seattle, Washington); Robert Alverson (Seattle, Washington) |
| ABSTRACT | Systems and methods are provided for passing data amongst a plurality of switches having a plurality of links attached between the plurality of switches. At a switch, a plurality of load signals are received from a plurality of neighboring switches. Each of the plurality of load signals are made up of a set of values indicative of a load at each of the plurality of neighboring switches providing the load signal. Each value within the set of values provides an indication for each link of the plurality of links attached thereto as to whether the link is busy or quiet. Based upon the plurality of load signals, an output link for routing a received packet is selected, and the received packet is routed via the selected output link. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479755 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/505 (20130101) G06F 9/546 (20130101) G06F 12/0862 (20130101) G06F 12/1036 (20130101) G06F 12/1063 (20130101) G06F 13/14 (20130101) G06F 13/16 (20130101) G06F 13/385 (20130101) G06F 13/1642 (20130101) G06F 13/1673 (20130101) G06F 13/1689 (20130101) G06F 13/4022 (20130101) G06F 13/4068 (20130101) G06F 13/4221 (20130101) G06F 15/17331 (20130101) G06F 2212/50 (20130101) G06F 2213/0026 (20130101) G06F 2213/3808 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0083 (20130101) H04L 43/10 (20130101) H04L 43/0876 (20130101) H04L 45/16 (20130101) H04L 45/20 (20130101) H04L 45/021 (20130101) H04L 45/22 (20130101) H04L 45/24 (20130101) H04L 45/028 (20130101) H04L 45/28 (20130101) Original (OR) Class H04L 45/38 (20130101) H04L 45/42 (20130101) H04L 45/46 (20130101) H04L 45/70 (20130101) H04L 45/122 (20130101) H04L 45/123 (20130101) H04L 45/125 (20130101) H04L 45/566 (20130101) H04L 45/745 (20130101) H04L 45/7453 (20130101) H04L 47/11 (20130101) H04L 47/12 (20130101) H04L 47/18 (20130101) H04L 47/20 (20130101) H04L 47/22 (20130101) H04L 47/24 (20130101) H04L 47/30 (20130101) H04L 47/32 (20130101) H04L 47/34 (20130101) H04L 47/39 (20130101) H04L 47/52 (20130101) H04L 47/76 (20130101) H04L 47/80 (20130101) H04L 47/122 (20130101) H04L 47/323 (20130101) H04L 47/621 (20130101) H04L 47/626 (20130101) H04L 47/629 (20130101) H04L 47/762 (20130101) H04L 47/781 (20130101) H04L 47/2441 (20130101) H04L 47/2466 (20130101) H04L 47/2483 (20130101) H04L 47/6235 (20130101) H04L 47/6275 (20130101) H04L 49/15 (20130101) H04L 49/30 (20130101) H04L 49/90 (20130101) H04L 49/101 (20130101) H04L 49/3009 (20130101) H04L 49/3018 (20130101) H04L 49/3027 (20130101) H04L 49/9005 (20130101) H04L 49/9021 (20130101) H04L 49/9036 (20130101) H04L 49/9047 (20130101) H04L 67/1097 (20130101) H04L 69/22 (20130101) H04L 69/28 (20130101) H04L 69/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240032821 | Sonkusale et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sameer Sonkusale (Lincoln, Massachusetts); Yiwen Jiang (West Windsor, New Jersey); Eric Miller (Newton, Massachusetts) |
| ABSTRACT | An apparatus for sensing motion of a subject's head comprises three conductive threads, each of which has a resistance that varies in response to strain thereof, circuitry for applying a voltage across the threads, circuitry for detecting current flowing through the threads, a data-collection system configured to detect the current, and a data-processing system that classifies, based on data provided by the data-collection system, a type of motion of the head and an extent of the motion. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 18/265555 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1114 (20130101) Original (OR) Class A61B 5/6822 (20130101) A61B 5/7267 (20130101) A61B 2560/0223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240032928 | SHARMA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vivifi Medical, Inc. (Rosharon, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tushar SHARMA (Houston, Texas); Nicolo GARBIN (Houston, Texas); Juan PARDO (Houston, Texas) |
| ABSTRACT | An apparatus includes an interface, and an elongate body coupled to the interface. An end effector is coupled to a distal end the elongate body and includes a first end effector element defining a first receptacle structured to hold a first coupler element of a coupler that receives an axial end of a first vessel, and a second end effector element defining a second receptacle structured to hold a second coupler element of the coupler that receives an axial end of a second vessel. The end effector is configured to move between a first configuration in which the first and second end effector elements are separate, and a second configuration in which first end effector element is proximate to the second end effector element such that the first coupler element is coupled to the second coupler element so as to couple the first vessel to the second vessel. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472615 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/11 (20130101) Original (OR) Class A61B 17/2909 (20130101) A61B 2017/00367 (20130101) A61B 2017/1107 (20130101) A61B 2017/1125 (20130101) A61B 2017/1132 (20130101) A61B 2017/2919 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033022 | Farritor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shane Farritor (Lincoln, Nebraska); Thomas Frederick (Gretna, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania); Eric Markvicka (Lincoln, Nebraska); Jack Mondry (Edina, Minnesota) |
| ABSTRACT | The various embodiments disclosed herein relate to improved robotic surgical systems, including robotic surgical devices having improved arm components and/or biometric sensors, contact detection systems for robotic surgical devices, gross positioning systems and devices for use in robotic surgical systems, and improved external controllers and consoles. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/482994 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/30 (20160201) Original (OR) Class A61B 2034/302 (20160201) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033242 | Shah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nisarg Shah (San Diego, California); David A. McBride (San Diego, California); Nunzio Bottini (La Jolla, California) |
| ABSTRACT | Described herein are compositions and methods for treating inflammatory arthritic conditions tint are effective systemically without causing generalized immunosuppression when administered locally into an inflammatory arthritis-affected joint or a draining lymph node of the arthritis-affected joint of a patient. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/474108 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5031 (20130101) A61K 31/203 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033403 | Howell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maine System Board of Trustees (Orono, Maine); University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Caitlin Lake Howell (Veazie, Maine); Marissa J. Andersen (South Bend, Indiana); Ana Lidia Flores Mireles (South Bend, Indiana) |
| ABSTRACT | Presented herein are devices, systems, and methods related to liquid infused substrates for use in medical applications. Adhesion of proteins, pathogens, and other substances to medical devices presents an issue. Proteins from the surrounding environment adhere to medical devices, which may, under certain conditions, result in the adhesion of pathogens to the medical device. The presence of these pathogens may result in infections when a medical device is inserted or otherwise placed in vivo (in whole or in part), which may require the removal of the device and/or treatment of the subject with antibiotics. Changing the surface properties of such devices can alter which proteins, pathogens, and/or other substances adhere and/or adsorb to the surface. Accordingly, in some embodiments, the present disclosure provides for technologies for altering surface adhesion and/or absorption of proteins, pathogens and/or other substances by infusing/impregnating a substrate of the device with an impregnation fluid. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/224842 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/06 (20130101) A61L 29/085 (20130101) Original (OR) Class A61L 2300/404 (20130101) A61L 2300/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033692 | ISLAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAFIQUL ISLAM (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RAFIQUL ISLAM (GILBERT, Arizona); Dianne Carrillo (Gilbert, Arizona); Yuqiang Bi (GILBERT, Arizona); ALI ANSARI (GILBERT, Arizona) |
| ABSTRACT | The present invention provides among other things a silver nanoparticle-coated membrane that reduces biofouling. The membranes exhibit extended antimicrobial properties that prevents the buildup that causes biofouling, which in turn prolongs the life of the membranes. The membranes may be reverse osmosis membranes, microfiltration membranes, ultrafiltration membranes, nanofiltration membranes, or any other membrane suitable for liquid processes. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/376368 |
| CURRENT CPC | Separation B01D 61/08 (20130101) B01D 61/18 (20130101) B01D 67/00933 (20220801) B01D 69/1214 (20220801) Original (OR) Class B01D 71/022 (20130101) B01D 2323/21811 (20220801) B01D 2325/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033737 | Flanagan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa A. Flanagan (Irvine, California); Alan Y. L. Jiang (Irvine, California); Jaclyn Nicole Hanamoto (Irvine, California); Clarissa C. Ro (Irvine, California) |
| ABSTRACT | The disclosure provides devices, methods and systems for continuous dielectrophoresis cell sorting to isolate different populations of cells, and applications thereof. |
| FILED | Wednesday, July 26, 2023 |
| APPL NO | 18/226739 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0645 (20130101) B01L 2300/0883 (20130101) B01L 2400/0424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034688 | FABER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Katherine T. FABER (Pasadena, California); Julia A. KORNFIELD (Pasadena, California); Noriaki ARAI (Pasadena, California); Orland BATEMAN (Pasadena, California); Rustem F. ISMAGILOV (Pasadena, California) |
| ABSTRACT | Provided herein are methods for making a freeze-cast material having a internal structure, the methods comprising steps of: determining the internal structure of the material, the internal structure having a plurality of pores, wherein: each of the plurality of pores has directionality; and the step of determining comprises: selecting a temperature gradient and a freezing front velocity to obtain the determined internal structure based on the selected temperature gradient and the selected freezing front velocity; directionally freezing a liquid formulation to form a frozen solid, the step of directionally freezing comprising: controlling the temperature gradient and the freezing front velocity to match the selected temperature gradient and the selected freezing front velocity during directionally freezing; wherein the liquid formulation comprises at least one solvent and at least one dispersed species; and subliming the at least one solvent out of the frozen solid to form the material. |
| FILED | Monday, July 31, 2023 |
| APPL NO | 18/228369 |
| CURRENT CPC | Separation B01D 67/0051 (20130101) B01D 69/02 (20130101) B01D 71/024 (20130101) B01D 2325/021 (20130101) B01D 2325/26 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 35/04 (20130101) B01J 35/1071 (20130101) B01J 35/1076 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 38/007 (20130101) C04B 38/0038 (20130101) C04B 38/0054 (20130101) C04B 38/0093 (20130101) C04B 38/0605 (20130101) Original (OR) Class Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/14 (20130101) H01B 1/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034754 | Berger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundatuion (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Bryan Berger (Charlottesville, Virginia); Holly Mayton (Alexandria, Virginia) |
| ABSTRACT | Provided are polypeptides that have at least about 95% but less than 100% sequence identity to SEQ ID NO: 2, optionally wherein the polypeptide has an amino acid sequence as set forth in SEQ ID NO: 4, with the proviso that the polypeptide does not have 100% sequence identity to SEQ ID NO: 2. Also provided are polypeptides that include an amino acid sequence that is a variant of SEQ ID NO: 2, wherein the variant sequence has at least one substitution at an amino acid position selected from the group consisting of D287, D291, D311, N313, D315, L307, and N284 of SEQ ID NO: 2; optionally wherein the polypeptide inhibits growth of a microbe and/or microbial biofilm and/or disrupts a microbial biofilm; nucleic acid molecules encoding the disclosed polypeptides; vectors and recombinant host cells that include the disclosed nucleic acid molecules; antimicrobial compositions that include an effective amount of the disclosed polypeptides, optionally that also include a carrier and/or one or more additional active agents; and methods for inhibiting the growth of microbes and/or microbial biofilms on surfaces and/or for disrupting microbial biofilms on surfaces and methods for inhibiting the growth of microbes on and/or in agricultural products and/or subjects. |
| FILED | Monday, May 08, 2023 |
| APPL NO | 18/314035 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/46 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/16 (20130101) Peptides C07K 14/01 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035052 | Lynch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods for rapid production of chemicals in genetically engineered microorganisms in a large scale. Also provided herein is a high-throughput metabolic engineering platform enabling the rapid optimization of microbial production strains. The platform, which bridges a gap between current in vivo and in vitro bio-production approaches, relies on dynamic minimization of the active metabolic network. |
| FILED | Monday, May 15, 2023 |
| APPL NO | 18/317588 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/0016 (20130101) C12N 9/0051 (20130101) C12N 9/1025 (20130101) C12N 15/746 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class C12P 13/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035494 | Do et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian H. Do (Plant City, Florida); Inrak Choi (Seoul, South Korea); Sean Weston Follmer (Palo Alto, California) |
| ABSTRACT | A variable impedance actuator is provided with a bladder-style actuator having a first end and a second end, and a jamming brake located inside the bladder-style actuator and connected to the first end and the second end of the bladder-style actuator. The bladder-style actuator and the jamming brake are independently controlled. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/379856 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/142 (20130101) B25J 19/0004 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/103 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240036042 — CLICK CHEMISTRY AMPLIFIED NANOPORE ASSAY FOR ULTRASENSITIVE QUANTIFICATION OF PROTEINS
| US 20240036042 | LIU |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHANG LIU (CHAPIN, South Carolina) |
| ABSTRACT | Methods disclosed herein are directed to methods of detecting and/or quantifying an antigen. The ultrasensitive Click chemistry Amplified Nanopore (CAN) assay has been engineered for antigen quantification in a biological sample. According to the present disclosure, the CAN assay is based on the combination of an amplified sandwich assay and nanopore sensing. Methods disclosed herein may be incorporated into a point-of-care test device with the necessary accuracy, portability, cost efficiency, and simplicity to fill the diagnostic gaps in high infectious disease burden areas. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363341 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5695 (20130101) G01N 33/54346 (20130101) G01N 33/56988 (20130101) Original (OR) Class G01N 2333/35 (20130101) G01N 2333/161 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036339 | Ünlü et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | M. Selim Ünlü (Newton, Massachusetts); Mete Aslan (Brighton, Massachusetts); Iris Celebi (Allston, Massachusetts); Celalettin Yurdakul (Santa Clara, California); Allison Marie Marn (Winchester, Massachusetts) |
| ABSTRACT | An exemplary illumination source is provided. The illumination source includes a light integrating device for coupling to at least one optical structure at an output port. The light integrating device includes at least one input port. At least one light source produces at least one optical illumination coupled to the at least one input port. A light adjusting tool controls the optical illumination emitted by the light integrating device. The light adjusting tool controls uniformity of light emitted by the light integrating device by modifying at least one internal surface of the light integrating device. |
| FILED | Wednesday, July 26, 2023 |
| APPL NO | 18/226483 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/08 (20130101) G02B 27/48 (20130101) G02B 27/0916 (20130101) G02B 27/0927 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240037339 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Robert Bosch GmbH (Stuttgart, Germany); The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pei Chen (College Station, Texas); Haibo Ding (Fremont, California); Jun Araki (San Jose, California); Ruihong Huang (College Station, Texas) |
| ABSTRACT | A computer-implemented method of Named Entity Recognition (NER) includes receiving an input, identifying a plurality of candidate entities corresponding to the input, assigning word embeddings to the input at an embedding layer, capturing sequential context of the word embeddings in an encoding layer to obtain encoded word embeddings, constructing an entity relation graph using global coreference relations and local dependency relations to obtain a coreference graph and a dependency graph, fusing the encoded word embeddings, coreference graph, and dependency graph, via a graphical neural network (GNN), to obtain updated word embeddings, and decoding the updated word embeddings via a decoding layer to obtain enriched entity predictions. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877543 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/35 (20200101) G06F 40/295 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240037394 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Deliang Fan (Tempe, Arizona); Fan Zhang (Tempe, Arizona); Li Yang (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Deliang Fan (Tempe, Arizona); Fan Zhang (Tempe, Arizona); Li Yang (Tempe, Arizona) |
| ABSTRACT | A neural network accelerator architecture for multiple task adaptation comprises a volatile memory comprising a plurality of subarrays, each subarray comprising M rows and N columns of volatile memory cells; a source line driver connected to a plurality of N source lines, each source line corresponding to a column in the subarray; a binary mask buffer memory having size at least N bits, each bit corresponding to a column in the subarray, where a 0 corresponds to turning off the column for a convolution operation and a 1 corresponds to turning on the column for the convolution operation; and a controller configured to selectively drive each of the N source lines with a corresponding value from the mask buffer; wherein each column in the subarray is configured to store a convolution kernel. |
| FILED | Thursday, July 27, 2023 |
| APPL NO | 18/360140 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Original (OR) Class G06N 3/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240038034 | Zhakypov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Juior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenishbek Zhakypov (Mountain View, California); Allison M. Okamura (Mountain View, California) |
| ABSTRACT | A fully 3-D printed, soft, monolithic 4-DoF fingertip haptic technology is provided, called FingerPrint, that stimulates linear and rotational shear, pressure, and vibration on the finger pad. Constructed using an origami waterbomb base mechanism and printed from a flexible material, the device embeds four sets of eight foldable vacuum-powered pneumatic actuators to achieve three translational (x, y, z) and one rotational (torsion) tactile motions and forces of a tactor end-effector on the finger pad skin. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/380033 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Electric Digital Data Processing G06F 3/016 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 6/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240038097 | REILEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Carol E. REILEY (Baltimore, Maryland); Gregory D. Hager (Baltimore, Maryland); Balakrishnan Varadarajan (Baltimore, Maryland); Sanjeey Pralhad Khudanpur (Baltimore, Maryland); Rajesh Kumar (Baltimore, Maryland); Henry C. Lin (Baltimore, Maryland) |
| ABSTRACT | A system quantifying clinical skill of a user, comprising: collecting data relating to a surgical task done by a user using a surgical device; comparing the data for the surgical task to other data for another similar surgical task; quantifying the clinical skill of the user based on the comparing of the data for the surgical task to the other data for the other similar surgical task; outputting the clinical skill of the user. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/484167 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/00 (20130101) G09B 5/02 (20130101) G09B 7/00 (20130101) G09B 19/00 (20130101) G09B 23/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240038517 | HOLLAND et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa HOLLAND (Morgantown, West Virginia); Stephen J. VALENTINE (Morgantown, West Virginia); Peng LI (Morgantown, West Virginia) |
| ABSTRACT | A device may include a separation capillary having an injection end and a distal end, the injection end configured to receive analyte liquid and the distal end configured to expel the analyte liquid. A device may include a sheath capillary covering the distal end of the separation capillary, the sheath capillary having a diameter that is greater than an outer diameter of the separation capillary at the distal end, the sheath capillary having a first end and a second end, the distal end of the separation capillary positioned between the first end and the second end of the sheath capillary, the sheath capillary carrying a fluid between the second end and the first end. A device may include an acoustic probe configured to vibrate positioned in contact with the at least one of the distal end of the separation capillary or the first end of the sheath capillary. |
| FILED | Monday, July 31, 2023 |
| APPL NO | 18/228599 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240039241 | Yun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seok-Hyun Yun (Belmont, Massachusetts); Paul Dannenberg (Cambridge, Massachusetts) |
| ABSTRACT | A first layer, a first spacer layer, and a second layer of a semiconductor wafer can be etched to produce a plurality of columnar structures extending from the substrate layer and including a first optical cavity situated about the first gain medium, a second optical cavity situated about the second gain medium, and a first spacer region contacting the first gain medium and the second gain medium. Also, a photonic microparticle formed from a layered semiconductor wafer and of a columnar structure having a first optical cavity situated about a first gain medium, a second optical cavity situated about a second gain medium, and a first spacer region contacting the first gain medium and the second gain medium. The first optical cavity and the second optical cavity in the photonic microparticle are each capable of generating laser light with a distinct spectral peak when energetically excited. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 18/044432 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0076 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/041 (20130101) H01S 5/0217 (20130101) H01S 5/1021 (20130101) Original (OR) Class H01S 5/1042 (20130101) H01S 5/1092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240032580 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/478654 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1203 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/36 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) A23L 31/00 (20160801) Original (OR) Class A23L 33/195 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/208 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/00 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033022 | Farritor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shane Farritor (Lincoln, Nebraska); Thomas Frederick (Gretna, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania); Eric Markvicka (Lincoln, Nebraska); Jack Mondry (Edina, Minnesota) |
| ABSTRACT | The various embodiments disclosed herein relate to improved robotic surgical systems, including robotic surgical devices having improved arm components and/or biometric sensors, contact detection systems for robotic surgical devices, gross positioning systems and devices for use in robotic surgical systems, and improved external controllers and consoles. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/482994 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/30 (20160201) Original (OR) Class A61B 2034/302 (20160201) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033682 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Matthew Green (Phoenix, Arizona); Mani Modayil Korah (Tempe, Arizona); Kyle Culp (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Green (Phoenix, Arizona); Mani Modayil Korah (Tempe, Arizona); Kyle Culp (Phoenix, Arizona) |
| ABSTRACT | A carbon dioxide capture composition includes a hydroxide-ion-exchanged poly(N-vinyl guanidine)-based polymer material as a sorbent. A method of preparing the carbon dioxide capture composition includes contacting a poly(N-vinyl guanidine)-based polymer material with hydroxide ion exchange beads, and exchanging hydroxide ion into the poly(N-vinyl guanidine)-based polymer material to form the sorbent. A carbon dioxide capture method includes contacting the sorbent with a gas stream, and sorbing carbon dioxide in the gas stream with the sorbent. A carbon dioxide capture system includes a sorption bed having a hydroxide-ion-exchanged poly(N-vinyl guanidine)-based polymer material as a sorbent. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/361657 |
| CURRENT CPC | Separation B01D 53/30 (20130101) B01D 53/62 (20130101) Original (OR) Class B01D 53/78 (20130101) B01D 53/96 (20130101) B01D 2253/202 (20130101) B01D 2257/504 (20130101) B01D 2259/40088 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) B01J 20/3425 (20130101) B01J 20/3466 (20130101) B01J 20/3475 (20130101) B01J 20/3483 (20130101) B01J 20/28016 (20130101) B01J 20/28023 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 126/02 (20130101) C08F 2810/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033708 | HERNANDEZ-MALDONADO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PUERTO RICO (Mayagüez, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arturo HERNANDEZ-MALDONADO (Mayagüez, Puerto Rico); Zhongfang Chen (Mayagüez, Puerto Rico); Rodinson ARRIETA-PEREZ (Mayagüez, Puerto Rico); Daniela RIVERA-MIRABAL (Mayagüez, Puerto Rico); Gabriela DEL VALLE-PEREZ (Mayagüez, Puerto Rico); Yinghe ZHAO (Mayagüez, Puerto Rico); Shiru LIN (Mayagüez, Puerto Rico); Dariana VEGA-SANTANDER (Mayagüez, Puerto Rico) |
| ABSTRACT | This disclosure relates to nanoporous pure silica zeolite (PSZ) adsorbents and uses thereof. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 18/258105 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/18 (20130101) Original (OR) Class B01J 20/2808 (20130101) B01J 20/3057 (20130101) B01J 20/3085 (20130101) B01J 20/3433 (20130101) B01J 20/3458 (20130101) B01J 20/28061 (20130101) B01J 20/28064 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/281 (20130101) C02F 2101/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034895 | Liu et al. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fei Liu et al. (Ames, Iowa); Tyler Kirscht (Ames, Iowa); Matthew Marander (Ames, Iowa); Liangkui Jiang (Changsha, China PRC); Hantang Qin (Ames, Iowa); Shan Jiang (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fei Liu et al. (Ames, Iowa); Tyler Kirscht (Ames, Iowa); Matthew Marander (Ames, Iowa); Liangkui Jiang (Changsha, China PRC); Hantang Qin (Ames, Iowa); Shan Jiang (Ames, Iowa) |
| ABSTRACT | An ink includes metal nanoparticles stabilized with cellulose or a cellulose derivative. A method of forming an electrically conductive pathway includes printing the ink on a substrate, and sintering the printed ink, to form the electrically conductive pathway on the substrate. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/361428 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/14 (20130101) Original (OR) Class C09D 11/033 (20130101) C09D 11/037 (20130101) C09D 11/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240038803 | Jewell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | April D. Jewell (Pasadena, California); Shouleh Nikzad (Pasadena, California); John J. Hennessy (Pasadena, California); Ghazaleh Kafaie Shirmanesh (Pasadena, California); Erika T. Hamden (Pasadena, California) |
| ABSTRACT | A process for fabricating a light detector with one or more antireflection (AR) and/or bandpass filter coatings deposited thereon by area-selective atomic layer deposition (ALD). The AR coatings may comprise a metal oxide or a metal fluoride, such as AlF3, Al2O3, and/or HfO2, and the bandpass filter coatings may comprise solar-blind bandpass filter coatings. The AR and/or bandpass filter coatings may be deposited with different thicknesses on different portions of the light detector using an intentional and controllable patterning by a lithography-based process. As a result, the AR and/or bandpass filter coatings provide a butcher-block style response profile with each of the different portions of the light detector targeting a specific bandpass of light. The AR and/or bandpass filter coatings comprise a linear variable filter (LVF) that provides a spatially varying response by the light detector. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/360969 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/115 (20130101) G02B 5/288 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14623 (20130101) Original (OR) Class H01L 27/14685 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240033254 | Abdallah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chadi Abdallah (New Haven, Connecticut); John Krystal (New Haven, Connecticut); Ronald Duman (New Haven, Connecticut); Gerard Sanacora (New Haven, Connecticut) |
| ABSTRACT | The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/483225 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0053 (20130101) A61K 31/135 (20130101) A61K 31/436 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/24 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240033516 | GANGULY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karunesh GANGULY (San Francisco, California); Preeya KHANNA (San Francisco, California); Kyungsoo KIM (Oakland, California) |
| ABSTRACT | Methods and apparatuses for treating a patient having a brain lesion (e.g., a stroke patient) by applying a charge-balanced, low-frequency alternating current stimulation (ACS) to a region of the patient's brain immediately before and/or during a directed movement. The charge-balanced, low-frequency ACS may have a depolarizing phase that is slower than the hyperpolarizing phase (e.g., the depolarizing phase may have a frequency of 15 Hz or less and the hyperpolarizing phase with a frequency greater than 15 Hz). The ACS stimulation field may be greater than 1.5 V/m. The ACS may be applied during a preferred excitation phase. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 18/264926 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36103 (20130101) Original (OR) Class A61N 1/36139 (20130101) A61N 1/36171 (20130101) A61N 1/36178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035019 | Robinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William H. Robinson (Palo Alto, California); Yann Chong Tan (Palo Alto, California); Jeremy Sokolove (Mountain View, California) |
| ABSTRACT | Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest. |
| FILED | Thursday, June 28, 2018 |
| APPL NO | 16/022579 |
| CURRENT CPC | Peptides C07K 16/00 (20130101) C07K 16/1242 (20130101) C07K 16/1271 (20130101) C07K 2317/21 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 2458/10 (20130101) G01N 2500/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036050 | Dash et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia); THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srikanta Dash (New Orleans, Louisiana); Yucel Aydin (New Orleans, Louisiana); Ali Riza Koksal (New Orleans, Louisiana) |
| ABSTRACT | Disclosed are methods of treating a subject having hepatocellular carcinoma (HCC) comprising administering an HCC therapeutic to a subject identified in need thereof, wherein the subject was identified as being in need of thereof by determining the subject had an increased expression level of glypican 3 (GPC3) and/or an increased number of GPC3-enriched exosomes/increase level of exosome-derived GPC3 (eGPC3) as compared to a control. Disclosed are methods of diagnosing and treating a subject comprising detecting whether GPC3 expression is increased in the subject and/or GPC3-enriched exosomes are increased; diagnosing the subject with HCC when the presence of elevated GPC3 and/or an increased number of GPC3-enriched exosomes is detected; and administering a therapeutically effective amount of an HCC therapeutic to the subject. Disclosed are methods of detecting HCC in a subject comprising determining the level of GPC3 positive exosomes and/or the expression level of exosome derived GPC3 in a sample obtained from a subject and comparing the level of GPC3 positive exosomes and/or the expression level of exosome derived GPC3 from the subject to a control, wherein an increase in the level of GPC3 positive exosomes and/or an increase in the expression level of exosome derived GPC3 in the subject, as compared to a control, is a detection of HCC in the subject. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356537 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) Original (OR) Class G01N 2333/46 (20130101) G01N 2800/52 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240033324 | Jaynes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GENVOR, INC. (DALLAS, Texas); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse M. Jaynes (Auburn, Alabama); Kanniah Rajasekaran (Metairie, Louisiana); Jeffrey W. Cary (Covington, Louisiana); Ronald Sayler (Farmington, Arkansas); Rajtilak Majumdar (Metairie, Louisiana) |
| ABSTRACT | Aspergillus flavus is an opportunistic, saprophytic fungus that infects maize and other fatty acid-rich food and feed crops and produces toxic and carcinogenic secondary metabolites known as aflatoxins. In vitro studies showed a five-fold increase in antifungal activity of AGM182 (vs. tachyplesin1) against A. flavus. Transgenic maize plants expressing AGM182 under maize Ubiquitin-1 promoter were produced through Agrobacterium-mediated transformation. PCR products confirmed integration of the AGM182 gene, while RT-PCR of maize RNA confirmed the presence of AGM182 transcripts. Maize kernel screening assay using a highly aflatoxigenic A. flavus strain (AF70) showed up to 72% reduction in fungal growth in the transgenic AGM182 seeds compared to isogenic negative control seeds. |
| FILED | Monday, July 03, 2023 |
| APPL NO | 18/346317 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1767 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8205 (20130101) C12N 15/8216 (20130101) C12N 15/8282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240034756 | Mosher |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Rebecca Mosher (Tucson, Arizona) |
| ABSTRACT | The disclosure provides mutant Brassica plants that have increased locules and seed production relative to native wild-type plants. Such plants include a point mutation in the clavata 1 gene (CLV1), such as a G->A substitution at position 1745 of the Brassica rapa coding sequence, which leads to an S582N substitution in the protein sequence. Equivalent substitutions can be made in any Brassicaceae coding/protein sequence. Also provided are methods of using such plants in breeding programs, as well as parts of such plants (such as seeds), and methods of making commodity products from such plants (e.g., oil). Also provided are mutant CLV1 sequences. Brassica plants harboring the disclosed CLV1 mutation can include other desirable traits, such as herbicide tolerance. |
| FILED | Monday, February 21, 2022 |
| APPL NO | 18/278283 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/20 (20180501) Peptides C07K 14/415 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/8205 (20130101) C12N 15/8287 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240036027 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min CHEN (Boston, Massachusetts); Joshua FOSTER (Boston, Massachusetts); Minji KIM (Boston, Massachusetts); Matthew MOORE (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein is a composition that involves a nanopore disposed in a membrane preparation, wherein the nanopore has an outer membrane protein G (OmpG) having 8 to 22 β-strands connected by a plurality of flexible loops on a first side of the membrane preparation and a plurality short turns on a second side of the membrane preparation, wherein a heterologous peptide is inserted within one or more of the flexible loops. Also disclosed herein is a method of detecting binding of a ligand to a target, the method involving: exposing a nanopore composition disclosed herein to a target; assessing a gating pattern of the nanopore; and detecting binding of the target to the heterologous peptide based on the gating pattern. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/338855 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240032580 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/478654 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1203 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/36 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) A23L 31/00 (20160801) Original (OR) Class A23L 33/195 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/208 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/00 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240035998 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | 2WITECH SOLUTIONS LLC (Lowell, Massachusetts) |
| ASSIGNEE(S) | 2WITECH SOLUTIONS LLC (Lowell, Massachusetts) |
| INVENTOR(S) | Qingwu Wang (Chelmsford, Massachusetts); Yufeng Ma (Boston, Massachusetts) |
| ABSTRACT | The present invention provides a sensing electrode, an electrochemical sensing system using the sensing electrode, methods of preparing and using the sensing electrode and the electrochemical sensing system. The sensing electrode includes a base electrode having a conductive surface, and a coating layer formed on the conductive surface. The coating layer has cavities or holes, each of which can be filled with, bound to, or occupied by, an analyte molecule. A decrease of conductivity of the sensing electrode is correlated to the number of cavities or holes that are filled with, bound to, or occupied by, the molecules of the analyte. The invention exhibits numerous technical merits such as suitability for field application, high sensitivity to analyte such as PFOA or PFAS at 1 ppt level, rapid response within minutes, and superior selectivity against interferences such as PFDA, PFOS, PFOSA, and PFHxA, among others. |
| FILED | Sunday, July 23, 2023 |
| APPL NO | 18/357129 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240035993 | Morton-Aslanis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Morton-Aslanis (Raleigh, North Carolina); Roger L. Barker (Raleigh, North Carolina); A. Shawn Deaton (Raleigh, North Carolina); Hai Bui (Raleigh, North Carolina); Mark Martin (Raleigh, North Carolina) |
| ABSTRACT | A flash fire instrumented manikin articulation system designed to evaluate the thermal protective performance of protective clothing when exposed to flames. The flash fire instrumented manikin articulation system includes an instrumented manikin and an articulation system designed to simulate exposure to a flash fire and simulate dynamic movement including walking and jogging. |
| FILED | Tuesday, July 18, 2023 |
| APPL NO | 18/223130 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 31/08 (20190201) Devices, Apparatus or Methods for Life-saving A62B 17/003 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/005 (20130101) Original (OR) Class Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20240035998 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | 2WITECH SOLUTIONS LLC (Lowell, Massachusetts) |
| ASSIGNEE(S) | 2WITECH SOLUTIONS LLC (Lowell, Massachusetts) |
| INVENTOR(S) | Qingwu Wang (Chelmsford, Massachusetts); Yufeng Ma (Boston, Massachusetts) |
| ABSTRACT | The present invention provides a sensing electrode, an electrochemical sensing system using the sensing electrode, methods of preparing and using the sensing electrode and the electrochemical sensing system. The sensing electrode includes a base electrode having a conductive surface, and a coating layer formed on the conductive surface. The coating layer has cavities or holes, each of which can be filled with, bound to, or occupied by, an analyte molecule. A decrease of conductivity of the sensing electrode is correlated to the number of cavities or holes that are filled with, bound to, or occupied by, the molecules of the analyte. The invention exhibits numerous technical merits such as suitability for field application, high sensitivity to analyte such as PFOA or PFAS at 1 ppt level, rapid response within minutes, and superior selectivity against interferences such as PFDA, PFOS, PFOSA, and PFHxA, among others. |
| FILED | Sunday, July 23, 2023 |
| APPL NO | 18/357129 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 20240039517 | WALL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Walter S. WALL (Malibu, California); Randall L. KUBENA (Malibu, California) |
| ABSTRACT | A method and an apparatus for coupling two nonlinear resonators via a nonlinear element to generate phononic frequency combs. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/133480 |
| CURRENT CPC | Pulse Technique H03K 3/01 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20240039836 | Roweth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Spring, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan Roweth (Bristol, United Kingdom); Edwin L. Froese (Burnaby, Canada); Joseph G. Kopnick (Chippewa Falls, Wisconsin); Andrew S. Kopser (Seattle, Washington); Robert Alverson (Seattle, Washington) |
| ABSTRACT | Systems and methods are provided for passing data amongst a plurality of switches having a plurality of links attached between the plurality of switches. At a switch, a plurality of load signals are received from a plurality of neighboring switches. Each of the plurality of load signals are made up of a set of values indicative of a load at each of the plurality of neighboring switches providing the load signal. Each value within the set of values provides an indication for each link of the plurality of links attached thereto as to whether the link is busy or quiet. Based upon the plurality of load signals, an output link for routing a received packet is selected, and the received packet is routed via the selected output link. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479755 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/505 (20130101) G06F 9/546 (20130101) G06F 12/0862 (20130101) G06F 12/1036 (20130101) G06F 12/1063 (20130101) G06F 13/14 (20130101) G06F 13/16 (20130101) G06F 13/385 (20130101) G06F 13/1642 (20130101) G06F 13/1673 (20130101) G06F 13/1689 (20130101) G06F 13/4022 (20130101) G06F 13/4068 (20130101) G06F 13/4221 (20130101) G06F 15/17331 (20130101) G06F 2212/50 (20130101) G06F 2213/0026 (20130101) G06F 2213/3808 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0083 (20130101) H04L 43/10 (20130101) H04L 43/0876 (20130101) H04L 45/16 (20130101) H04L 45/20 (20130101) H04L 45/021 (20130101) H04L 45/22 (20130101) H04L 45/24 (20130101) H04L 45/028 (20130101) H04L 45/28 (20130101) Original (OR) Class H04L 45/38 (20130101) H04L 45/42 (20130101) H04L 45/46 (20130101) H04L 45/70 (20130101) H04L 45/122 (20130101) H04L 45/123 (20130101) H04L 45/125 (20130101) H04L 45/566 (20130101) H04L 45/745 (20130101) H04L 45/7453 (20130101) H04L 47/11 (20130101) H04L 47/12 (20130101) H04L 47/18 (20130101) H04L 47/20 (20130101) H04L 47/22 (20130101) H04L 47/24 (20130101) H04L 47/30 (20130101) H04L 47/32 (20130101) H04L 47/34 (20130101) H04L 47/39 (20130101) H04L 47/52 (20130101) H04L 47/76 (20130101) H04L 47/80 (20130101) H04L 47/122 (20130101) H04L 47/323 (20130101) H04L 47/621 (20130101) H04L 47/626 (20130101) H04L 47/629 (20130101) H04L 47/762 (20130101) H04L 47/781 (20130101) H04L 47/2441 (20130101) H04L 47/2466 (20130101) H04L 47/2483 (20130101) H04L 47/6235 (20130101) H04L 47/6275 (20130101) H04L 49/15 (20130101) H04L 49/30 (20130101) H04L 49/90 (20130101) H04L 49/101 (20130101) H04L 49/3009 (20130101) H04L 49/3018 (20130101) H04L 49/3027 (20130101) H04L 49/9005 (20130101) H04L 49/9021 (20130101) H04L 49/9036 (20130101) H04L 49/9047 (20130101) H04L 67/1097 (20130101) H04L 69/22 (20130101) H04L 69/28 (20130101) H04L 69/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240035797 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongliang Yang (Ellicott City, Maryland); Phuc M. Nguyen (Merrifield, Virginia) |
| ABSTRACT | Devices and methods for quickly and accurately measuring the distance between two carriers of item processing equipment. The devices and methods can include an elongate bar and associated components which may increase the magnitude of lengths that can be measured. |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/487866 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 5/02 (20130101) Original (OR) Class G01B 5/0004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, February 01, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240201.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page