FedInvent™ Patent Applications
Application Details for Thursday, February 08, 2024
This page was updated on Tuesday, June 18, 2024 at 02:13 PM GMT
Department of Health and Human Services (HHS)
| US 20240041023 | OU et al. |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH and HUMAN SERVICES (Bethesda, Maryland); Third Affiliated Hospital of Sun Yat-Sen University (Guangzhou, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingxing OU (Bethesda, Maryland); Guanghui JIN (Guangzhou City, China PRC); Yang YANG (Guangzhou, China PRC); Wei LIU (Guangzhou, China PRC); Lihao GE (Rockville, Maryland); Kiyoharu Joshua MIYAGISHIMA (Laurel, Maryland); Wei LI (Potomac, Maryland) |
| ABSTRACT | Composition for treating a cell, tissue or organ to withstand exposure and/or preserve viability when exposed to a low temperature environment, and methods for using such compositions. The cell, tissue, or organ is preferably a cornea or corneal cell. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 18/258125 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) A01N 1/0226 (20130101) A01N 1/0284 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041343 | Pandolfino et al. |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | John Erik Pandolfino (Evanston, Illinois); Dustin Allan Carlson (Evanston, Illinois); Wenjun Kou (Evanston, Illinois) |
| ABSTRACT | A catheter-based baro-hydrometer device measures or otherwise monitors esophageal function. The device includes a segmented balloon design, including a first and second balloon whose fill volumes can be independently controlled. In general, the device leverages secondary peristalsis related to balloon distention in order to study esophageal function. Pressure sensors coupled to the balloons record pressure data, which can be classified and processed to measure or otherwise monitor esophageal function. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/546592 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/037 (20130101) Original (OR) Class A61B 5/687 (20130101) A61B 5/1107 (20130101) A61B 5/6853 (20130101) A61B 5/7267 (20130101) A61B 2562/0247 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/1011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041345 | Grissom et al. |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
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| INVENTOR(S) | William A. Grissom (Nashville, Tennessee); Charles F. Caskey (Nashville, Tennessee) |
| ABSTRACT | A system and method of magnetic particle imaging (MPI) are disclosed. The system and method use ultrasound to drive magnetic particles (such as nanoparticles) through a magnetic field gradient to generate a signal and map the magnetic particles' distribution or concentration. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/382643 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0035 (20130101) A61B 5/0515 (20130101) Original (OR) Class A61B 8/485 (20130101) A61B 2562/0223 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/8906 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041358 | Chevillet et al. |
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| APPLICANT(S) | University of Washington (Seattle, Washington); Fred Hutchinson Cancer Research Center (Seattle, Washington) |
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| INVENTOR(S) | John R. Chevillet (Seattle, Washington); Tatiana D. Khokhlova (Seattle, Washington); George R. Schade (Seattle, Washington); Joo Ha Hwang (Bellevue, Washington); Muneesh Tewari (Seattle, Washington) |
| ABSTRACT | The present disclosure is directed to relates to systems and methods for evaluating tissue using high intensity focused ultrasound (HIFU) energy. In one embodiment, for example, a system for treating a patient comprises an ultrasound source configured to deliver HIFU energy to a target tissue mass of the patient and a function generator operably coupled to the ultrasound source for initiating a pulsing protocol for delivering the HIFU energy. The system further comprises a controller configured to perform operations comprising applying HIFU energy to induce cavitation in the target tissue mass and cause a biomarker to be released, comparing a baseline concentration of the biomarker from a first fluid sample to a concentration of the biomarker in a second fluid sample within 2 hours after applying HIFU, and repeating the applying and comparing until the concentration of the biomarker in the fluid sample falls below a threshold value. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/094206 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/15 (20130101) A61B 5/145 (20130101) A61B 5/4836 (20130101) A61B 5/14507 (20130101) A61B 5/14546 (20130101) Original (OR) Class A61B 8/08 (20130101) A61B 8/5223 (20130101) A61B 10/007 (20130101) A61B 10/0038 (20130101) A61B 2010/0077 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) A61N 7/022 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041388 | Mahadevan-Jansen et al. |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
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| INVENTOR(S) | Anita Mahadevan-Jansen (Nashville, Tennessee); Lisa White (Nashville, Tennessee); John Phay (Bexley, Ohio); Constantine A. Paras (Nashville, Tennessee); Elizabeth Kanter Bartz (Southlake, Texas); Matthew D. Keller (Kirkland, Washington); Nicole Mathews (St. Petersburg, Florida); Jennifer Whisenant Amundson (Nashville, Tennessee); Isaac J. Pence (Crestwood, Kentucky) |
| ABSTRACT | A system facilitating differentiation between parathyroid tissue and thyroid tissue of a subject comprises a light source for illuminating tissue in a target region in the neck area of the subject; a light delivery device that is optically coupled with the light source for delivering a beam of light from the light source to the tissue; a collection device for collecting optical signals emitted from the tissue responsive to the beam of light; and a detector for detecting the intensities of the optical signals emitted from the tissue, wherein differences in the detected intensities enable a user to differentiate between parathyroid tissue and thyroid tissue. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/379251 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/0075 (20130101) A61B 5/0086 (20130101) A61B 5/415 (20130101) Original (OR) Class A61B 5/418 (20130101) A61B 5/742 (20130101) A61B 5/4227 (20130101) A61B 34/20 (20160201) A61B 2034/2055 (20160201) A61B 2505/05 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 21/6456 (20130101) G01N 2021/6439 (20130101) G01N 2201/0221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041412 | Xie et al. |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (TROY, New York) |
| INVENTOR(S) | Huidong Xie (Troy, New York); Ge Wang (Loudonville, New York); Hongming Shan (Troy, New York); Wenxiang Cong (Albany, New York) |
| ABSTRACT | A system for few-view computed tomography (CT) image reconstruction is described. The system includes a preprocessing module, a first generator network, and a discriminator network. The preprocessing module is configured to apply a ramp filter to an input sinogram to yield a filtered sinogram. The first generator network is configured to receive the filtered sinogram, to learn a filtered back-projection operation and to provide a first reconstructed image as output. The first reconstructed image corresponds to the input sinogram. The discriminator network is configured to determine whether a received image corresponds to the first reconstructed image or a corresponding ground truth image. The generator network and the discriminator network correspond to a Wasserstein generative adversarial network (WGAN). The WGAN is optimized using an objective function based, at least in part, on a Wasserstein distance and based, at least in part, on a gradient penalty. |
| FILED | Wednesday, October 18, 2023 |
| APPL NO | 18/381214 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) Original (OR) Class A61B 6/5205 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) G06T 11/006 (20130101) G06T 2211/421 (20130101) G06T 2211/436 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041437 | Bhuyan et al. |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
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| INVENTOR(S) | Anshuman Bhuyan (Milpitas, California); Jung Woo Choe (Sunnyvale, California); Amin Nikoozadeh (Palo Alto, California); Butrus T. Khuri-Yakub (Palo Alto, California) |
| ABSTRACT | Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements. |
| FILED | Monday, June 19, 2023 |
| APPL NO | 18/337270 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/54 (20130101) Original (OR) Class A61B 8/4483 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) A61N 7/02 (20130101) A61N 2007/0021 (20130101) A61N 2007/0052 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0215 (20130101) B06B 1/0292 (20130101) B06B 2201/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041558 | SIEWERDSEN et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jeffrey H. SIEWERDSEN (Baltimore, Maryland); Niral M. SHETH (Baltimore, Maryland); Prasad VAGDARGI (Baltimore, Maryland); Greg M. OSGOOD (Baltimore, Maryland); Wathudurage Tharindu DE SILVA (Baltimore, Maryland) |
| ABSTRACT | A system for surgical navigation, including an instrument for a medical procedure attached to a camera and having a spatial position relative to the camera, an x-ray system to acquire x-ray images, and multiple fiducial markers detectable by both the camera and x-ray system, having a radio-opaque material arranged as at least one of a line and a point. A computer receives an optical image from the camera and an x-ray image from the x-ray system, identifies fiducial markers visible in both the optical image and x-ray image, determines for each fiducial marker a spatial position relative to the camera based on the optical image and relative to the x-ray system based on the x-ray image, and determines a spatial position for the instrument relative to the x-ray system based on at least the spatial positions relative to the camera and x-ray system. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 18/266433 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 90/39 (20160201) Original (OR) Class A61B 2090/3966 (20160201) Image Data Processing or Generation, in General G06T 7/33 (20170101) G06T 7/80 (20170101) G06T 2207/10016 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10121 (20130101) G06T 2207/30008 (20130101) G06T 2207/30204 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041575 | Esquivel-Upshaw et al. |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
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| INVENTOR(S) | Josephine F. Esquivel-Upshaw (Gainesville, Florida); Fan Ren (Gainesville, Florida); Patrick Carey (Gainesville, Florida); Arthur E. Clark, JR. (Gainesville, Florida); Christopher D. Batich (Gainesville, Florida) |
| ABSTRACT | Disclosed herein is a method for forming an anti-microbial layer on an apparatus. Also disclosed is a method for improving the anti-bacterial properties of a titanium device coated with titanium-nitride (TiN). Also disclosed is a medical apparatus comprising an anti-microbial layer prepared by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/489926 |
| CURRENT CPC | Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 8/0013 (20130101) A61C 13/0835 (20130101) Original (OR) Class A61C 2201/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041650 | Maminishkis |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Arvydas Maminishkis (Bethesda, Maryland) |
| ABSTRACT | Disclosed are devices and methods for delivering a sheet of tissue into the eye in such a way that damage to the tissue is minimized, damage to the eye during insertion and manipulation of the tissue is minimized, and the tissue is released and delivered in a precise and controlled fashion. |
| FILED | Monday, August 14, 2023 |
| APPL NO | 18/233654 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0008 (20130101) A61F 9/0026 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041768 | Maritim et al. |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
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| INVENTOR(S) | Samuel Maritim (New Haven, Connecticut); Ligia Boisserand (New Haven, Connecticut); Fahmeed Hyder (New Haven, Connecticut); Lauren Sansing (New Haven, Connecticut) |
| ABSTRACT | Provided herein are hypoxia/acidic targeting compounds formulated in lipid-containing nanoparticles (liposomes) containing a diagnostic and/or a therapeutic agent. These nanoparticles can penetrate the blood-brain barrier (BBB) and are useful in the treatment ischemic conditions, as well as systemic conditions with hypoxic environments, such as tumors. |
| FILED | Monday, July 24, 2023 |
| APPL NO | 18/357810 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 31/7076 (20130101) A61K 45/06 (20130101) A61K 51/1234 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041781 | Goldberg et al. |
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| APPLICANT(S) | Privo Technologies, Inc (Peabody, Massachusetts) |
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| INVENTOR(S) | Manijeh Nazari Goldberg (Newburyport, Massachusetts); Aaron Manzi (Atkinson, New Hampshire); Brandon LaPorte (Methuen, Massachusetts); Amritpreet Birdi (Hudson, New Hampshire) |
| ABSTRACT | A system for delivery of a therapeutic agent to a site in mucosal tissue is provided. The system includes a porous, mucoadhesive polymeric matrix having a first and a second opposed surfaces. The matrix is formed by a composition including chitosan. The composition may also include any or all of a hydration promotor, a microparticle adhesion inhibitor, and a microparticle aggregation inhibitor. A plurality of microparticles having an average diameter between 500 nm and 2000 nm are embedded within the matrix. The microparticles contain a therapeutic agent and have a coating around the therapeutic agent. The first surface of the matrix is configured to be attached to the site in the mucosal tissue and the matrix is configured to provide controlled release of the microparticles through the first surface. The coating of the microparticles includes chitosan so as to provide controlled release of the agent from the microparticles. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/112636 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/70 (20130101) A61K 9/485 (20130101) A61K 9/4866 (20130101) A61K 9/5036 (20130101) Original (OR) Class A61K 9/5161 (20130101) A61K 31/282 (20130101) A61K 31/407 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041798 | Tuohy et al. |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
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| INVENTOR(S) | Vincent K. Tuohy (Broadview Height, Ohio); Suparna Mazumder (Olmsted Falls, Ohio); Justin M. Johnson (Willoughby Hills, Ohio) |
| ABSTRACT | Provided herein are methods, kits and compositions for the treatment and/or prevention of ovarian cancer through the induction of an immune response against Anti-Mullerian Hormone Receptor, Type II (AMHR2). |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/462648 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/138 (20130101) Original (OR) Class A61K 31/337 (20130101) A61K 31/502 (20130101) A61K 31/555 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/4196 (20130101) A61K 31/4745 (20130101) A61K 31/4985 (20130101) A61K 31/7048 (20130101) A61K 31/7064 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 33/244 (20190101) A61K 39/001102 (20180801) A61K 45/06 (20130101) A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041805 | SMYTH et al. |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
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| INVENTOR(S) | Hugh D.C. SMYTH (Austin, Texas); Ashlee BRUNAUGH (Austin, Texas); Zachary N. WARNKEN (Austin, Texas); Hyo-Jong SEO (Austin, Texas) |
| ABSTRACT | The present disclosure provides pharmaceutical compositions of niclosamide and a protein that may be administered via inhalation These compositions may be used in nebulized, nasal, and inhaler formats. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 18/044877 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0075 (20130101) A61K 31/167 (20130101) Original (OR) Class A61K 38/47 (20130101) A61K 47/14 (20130101) A61K 47/26 (20130101) A61K 47/183 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/14 (20180101) Enzymes C12Y 302/01017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041807 | Marini et al. |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
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| INVENTOR(S) | Juan C. Marini (Houston, Texas); Sandesh Chakravarthy Sreenath Nagamani (Bellaire, Texas) |
| ABSTRACT | Embodiments of the disclosure include certain formulations for methods of treating urea cycle disorders. The methods encompass compositions that comprise benzoate and phenylbutyrate that may be at certain doses and have certain ratios of the components. The benzoate and phenylbutyrate may act synergistically in treatment of the urea cycle disorders, in particular embodiments. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/485093 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/216 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041808 | JABLONSKI |
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| APPLICANT(S) | OCULOTHERAPY, LLC (MEMPHIS, Tennessee) |
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| INVENTOR(S) | Monica M. JABLONSKI (Memphis, Tennessee) |
| ABSTRACT | This invention is directed to a method of preventing ocular neurodegeneration in a subject in need thereof. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 18/022252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 9/113 (20130101) A61K 31/197 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041813 | BAZAN |
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| APPLICANT(S) | Boards of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
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| INVENTOR(S) | Nicolas G. BAZAN (New Orleans, Louisiana) |
| ABSTRACT | This disclosure is directed is directed to compositions and methods for preventing, treating, or ameliorating the symptoms of a viral infection. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 18/025604 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/202 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041831 | Falck et al. |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); New York Medical College (Valhalla, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John R. Falck (Austin, Texas); Michal L. Schwartzman (Valhalla, New York); Victor Garcia (Valhalla, New York) |
| ABSTRACT | The present invention concerns compounds and their use to treat cardiovascular disease, renal disease, thrombic disease, stroke, metabolic syndrome, cell proliferation, and ischemic cardiovascular disorders. Compounds of the present invention display significant potency as antagonists of 20-hydroxyeicosatetraenoic acid (20-HETE), and function as anti-hypertensive, anti-inflammatory, or anti-growth agents. |
| FILED | Tuesday, May 09, 2023 |
| APPL NO | 18/314623 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) Original (OR) Class A61K 31/197 (20130101) A61K 31/201 (20130101) A61K 47/542 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Acyclic or Carbocyclic Compounds C07C 59/42 (20130101) C07C 233/49 (20130101) C07C 247/12 (20130101) Heterocyclic Compounds C07D 257/04 (20130101) C07D 257/06 (20130101) Peptides C07K 14/723 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) C40B 40/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 2333/705 (20130101) G01N 2500/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041838 | Fan et al. |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhichao Fan (Farmington, Connecticut); Bruce T. Liang (Avon, Connecticut) |
| ABSTRACT | Compositions and methods for the treatment of a human subject in need of treatment for a neutrophil-related condition, in particular who has had a stroke or myocardial ischemia reperfusion injury, by administering to the subject a pharmaceutical composition including a compound of Formula 1, wherein the substituents are as described herein, and in particular wherein the compound is 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one. |
| FILED | Monday, July 31, 2023 |
| APPL NO | 18/362485 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4196 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041847 | Palczewski et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krzysztof Palczewski (Ivrine, California); Yuanyuan Chen (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I). |
| FILED | Tuesday, September 05, 2023 |
| APPL NO | 18/461023 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) A61K 31/381 (20130101) A61K 31/4402 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041849 | CHOU et al. |
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| FUNDED BY |
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| APPLICANT(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| ASSIGNEE(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| INVENTOR(S) | James C. CHOU (Mt. Pleasant, South Carolina); Sherine S.L. CHAN (Charleston, South Carolina); Richard A. HIMES (Charleston, South Carolina) |
| ABSTRACT | Compounds and methods are provided for the treatment of neurological or mitochondrial diseases, including epilepsy. In some embodiments, the compounds are substituted 1,4-naphthoquinones. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/478261 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/136 (20130101) A61K 31/4406 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041851 | Mootha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vamsi Mootha (Boston, Massachusetts); Benjamin Gewurz (Boston, Massachusetts) |
| ABSTRACT | A method of treating and preventing viral infection in a subject comprising administering an effective amount of one or more inhibitors of folate or one-carbon metabolism pathways to the subject. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 18/265030 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/426 (20130101) A61K 31/427 (20130101) A61K 31/454 (20130101) A61K 31/505 (20130101) A61K 31/4162 (20130101) A61K 31/4412 (20130101) Original (OR) Class A61K 31/4418 (20130101) A61K 31/4439 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041859 | Mahjoub et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Mohamed 'Moe' Mahjoub (St. Louis, Missouri); Tao Cheng (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of a method of treating or preventing kidney disease in a subject in need thereof. Another aspect of the present disclosure provides for a method of reducing a number of kidney cells having excess centrosomes or centrosome amplification (CA) or inhibiting centrosome clustering in a subject having or suspected of having a kidney disease associated with CA or increased centrosome clustering. In some embodiments, the method comprises administering to the subject a centrosome clustering inhibiting agent. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 18/255655 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/473 (20130101) A61K 31/4745 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041881 | Habib |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amyn Aziz Habib (Washington, District of Columbia) |
| ABSTRACT | Provided herein are methods and pharmaceutical compositions for treating cancer, in a patient in need thereof, said method comprising administering to said patient an effective amount of an EGFR inhibitor and a TNF inhibitor. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/141965 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/573 (20130101) A61K 38/1793 (20130101) A61K 39/395 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041898 | Covey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Covey (St. Louis, Missouri); Charles Zorumski (St. Louis, Missouri); Yukitoshi Izumi (St. Louis, Missouri); Makoto Ishikawa (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to a composition for prevention or treatment of neurodegenerative conditions. The composition comprises a neurosteroid, a synthetic enantiomer of a neurosteroid, or a combination thereof. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046244 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 31/57 (20130101) Original (OR) Class A61K 47/40 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041900 | Slusher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barbara Slusher (Kingsville, Maryland); David Volsky (Scarsdale, New York); Mike Nedelcovych (Richmond, Virginia); Kristen Hollinger (Parkton, Maryland); Atsushi Kamiya (Pikesville, Maryland) |
| ABSTRACT | The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification, for use in treating cognitive deficits and/or psychiatric disorders, such as those associated with neurological or neurodegenerative disorders, psychiatric or mood disorders, and HIV-associated neurocognitive disorders (HAND). Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479357 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/198 (20130101) A61K 31/223 (20130101) A61K 31/655 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041906 | Heneine et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Walid Heneine (Atlanta, Georgia); Thomas M. Folks (Helotes, Texas); Robert Janssen (Atlanta, Georgia); Ronald A. Otten (Villa Rica, Georgia); Jose Gerardo Garcia Lerma (Decatur, Georgia) |
| ABSTRACT | A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation. |
| FILED | Thursday, August 17, 2023 |
| APPL NO | 18/235285 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 9/0053 (20130101) A61K 31/513 (20130101) A61K 31/675 (20130101) Original (OR) Class A61K 31/683 (20130101) A61K 31/7072 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041931 | DAVAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Diwakar DAVAR (Pittsburgh, Pennsylvania); Hassane Mohamed ZAROUR (Pittsburgh, Pennsylvania); Giorgio TRINCHIERI (Bethesda, Maryland); Amiran Kasanovich DZUTSEV (Bethesda, Maryland) |
| ABSTRACT | Disclosed herein are methods for treating cancer by administering an anti-PD-1 antibody and a fecal sample obtained from a donor that is responsive to an anti-PD-1 therapy. Specifically, the cancer comprising a melanoma, and a metastatic melanoma; and wherein the fecal sample comprises a higher level of bacteria of phylum Actinobacteria and/or phylum Firmicutes in comparison to a control. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 18/266455 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/24 (20130101) Original (OR) Class A61K 35/741 (20130101) A61K 39/3955 (20130101) A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041941 | Bolli |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roberto Bolli (Louisville, Kentucky) |
| ABSTRACT | Methods to treat heart failure and reduce systemic inflammation are provided. The methods include systemically delivering to a subject at least two doses, for example 2-10 doses, of mesenchymal stem cells, wherein the at least two doses are separated by an interval of time, such as from 1 day to 1 year. |
| FILED | Friday, August 04, 2023 |
| APPL NO | 18/230278 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/51 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041978 | Chernomordik et al. |
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| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Leonid V. Chernomordik (North Potomic, Maryland); Evgenia Leikina (Derwood, Maryland); Jarred M. Whitlock (Kengsington, Maryland) |
| ABSTRACT | Methods are disclosed herein for modulating osteoclast fusion. In some embodiments, these methods include administering an effective amount of a Lupus autoantigen (La) protein, or an agent that modulates La protein expression or activity, to a subject in need thereof, thereby modulating osteoclast fusion in the subject. In some embodiments, the method increases osteoclast fusion and bone resorption. In other embodiments, the method decreases osteoclast fusion and bone resorption. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/279476 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041985 | Jankowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. Jankowski (Union, Kentucky); Xiaohua Liu (Cincinnati, Ohio); John Barns Rose (Cincinnati, Ohio) |
| ABSTRACT | Disclosed are methods of treating pain in a mammal, which may include the step of administering human growth hormone to a mammal in need thereof. The pain treated by the disclosed methods may be of a type caused by inflammation induced mechanical and/or thermal hypersensitivity, and may include, for example, a pain type resulting from one or more conditions selected from peripheral injury pain, post-operative pain, cutaneous inflammation, cutaneous incision, muscle incision, or chronic pain. Disease states in which the disclosed methods may be used include fibromyalgia, sickle cell anemia, epidermolysis bullosa, erythromelalgia, complex regional pain syndrome, or generalized muscle pain. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/380877 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/27 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041989 | Zhan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chang-Guo Zhan (Lexington, Kentucky); Fang Zheng (Lexington, None) |
| ABSTRACT | The presently disclosed subject matter describes methods of treating cocaine use disorder and organophosphorus toxicity in which a butyrylcholinesterase fusion protein is administered to a subject in need thereof. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 18/268575 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/30 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/18 (20130101) Enzymes C12Y 301/01008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041994 | LANIER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lewis L. LANIER (San Francisco, California); William H. HILDEBRAND (Oklahoma City, Oklahoma) |
| ABSTRACT | The present invention provides vaccine compositions for preventing and/or treating cytomegalovirus (CMV) infection and methods of making and using the same. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0005 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 39/3955 (20130101) A61K 2039/58 (20130101) A61K 2039/505 (20130101) A61K 2039/572 (20130101) Peptides C07K 14/70539 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041996 | Masopust, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David B. Masopust, JR. (Minneapolis, Minnesota); Vaiva D. Vezys (Minneapolis, Minnesota) |
| ABSTRACT | Provided herein are methods of treating cancer by activating resident memory T cells using one or more antigenic peptides. |
| FILED | Monday, April 03, 2023 |
| APPL NO | 18/130166 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/395 (20130101) A61K 39/39558 (20130101) A61K 48/0058 (20130101) A61K 2039/585 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/10034 (20130101) C12N 2760/20234 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042033 | Khan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Atif J. Khan (Monroe, New Jersey); Suzie Chen (Highland Park, New Jersey); James S. Goydos (East Brunswick, New Jersey); Bruce G. Haffty (Somerset, New Jersey) |
| ABSTRACT | Disclosed is a method of treating a tumor in a patient, comprising (a) administering riluzole in an amount effective to sensitize the tumor cells to ionizing radiation, and (b) irradiating the tumor cells with ionizing radiation in a dose effective to reduce tumor cell growth. The method can further comprise administering an effective amount of one or more additional therapeutic agents. |
| FILED | Wednesday, October 18, 2023 |
| APPL NO | 18/489642 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042039 | Manoharan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARBUTUS BIOPHARMA CORPORATION (Vancouver, Canada) |
| ASSIGNEE(S) | ARBUTUS BIOPHARMA CORPORATION (Vancouver, Canada) |
| INVENTOR(S) | Muthiah Manoharan (Cambridge, Massachusetts); Muthusamy Jayaraman (Cambridge, Massachusetts); Kallanthottathil G. Rajeev (Cambridge, Massachusetts); Laxman Eltepu (Cambridge, Massachusetts); Steven Ansell (Cambridge, Massachusetts); Jianxin Chen (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure wherein: R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O). |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/194540 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 31/713 (20130101) A61K 31/7088 (20130101) A61K 39/00 (20130101) A61K 39/39 (20130101) A61K 47/10 (20130101) A61K 47/18 (20130101) A61K 47/20 (20130101) A61K 47/28 (20130101) A61K 47/44 (20130101) Original (OR) Class A61K 2039/55555 (20130101) A61K 2039/55561 (20130101) Acyclic or Carbocyclic Compounds C07C 229/08 (20130101) C07C 229/30 (20130101) C07C 237/16 (20130101) C07C 251/38 (20130101) C07C 251/78 (20130101) C07C 271/12 (20130101) C07C 271/20 (20130101) C07C 323/25 (20130101) Heterocyclic Compounds C07D 203/10 (20130101) C07D 317/28 (20130101) C07D 317/44 (20130101) C07D 317/46 (20130101) C07D 317/72 (20130101) C07D 319/06 (20130101) C07D 405/12 (20130101) C07D 491/056 (20130101) C07D 491/113 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/3515 (20130101) C12N 2320/32 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042042 | Lencer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Wayne I. Lencer (Jamaica Plain, Massachusetts); Daniel JF Chinnapen (Quincy, Massachusetts); Richard I. Duclos (Quincy, Massachusetts) |
| ABSTRACT | Provided herein, in some aspects, are delivery vehicles comprising a ceramide and an agent to be delivered attached to the ceramide. In some embodiments, the ceramide does not comprise a fatty acid (i.e., is a sphingosine). In some embodiments, the ceramide comprises a fatty acid. In some embodiments, the ceramide is a glycoceramide. In some embodiments, the agent is attached to the ceramide covalently (e.g., via a linker). In some embodiments, the agent to be delivered is a therapeutic agent. The ceramide is able to deliver the agent to a cell or to a cellular compartment, as well as across the musical barrier. In some embodiments, agents delivered using the ceramide described herein exhibit longer half-life, compared to agents delivered alone. Methods of delivering a therapeutic agent to a subject for treating a disease using the ceramide delivery vehicle are also provided. |
| FILED | Friday, August 11, 2023 |
| APPL NO | 18/448578 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1617 (20130101) A61K 31/7105 (20130101) A61K 47/65 (20170801) A61K 47/543 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042045 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenbin Lin (Chicago, None); Xiaomin Jiang (Chicago, None); Wenbo Han (Chicago, None); Xuanyu Feng (Chicago, None) |
| ABSTRACT | Prodrugs that target the low-density lipoprotein receptor (LDLR) and that comprise acid and/or enzyme cleavable acetal- or oxybenzyloxy-linked carbonate or carbamate bonds are described. Also described are core-shell nanoparticles comprising metal-organic framework cores or nanoscale metal bisphosphate coordination polymer cores, and lipid coating layers containing the prodrugs. The nanoparticle core can optionally contain one or more hydrophilic chemotherapeutic agents. The prodrugs and nanoparticles can be used in methods of treating cancer. For instance, the presently disclosed nanoparticles can be used for the co-delivery of multiple chemotherapeutic agents in methods providing increased accumulation of chemotherapeutic agents to a tumor compared to delivery of mixtures of free chemotherapeutic agents. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 18/022296 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/554 (20170801) Original (OR) Class A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Steroids C07J 43/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042063 | RESHETNYAK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES (Kingston, Rhode Island); YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yana K. RESHETNYAK (Saunderstown, Rhode Island); Oleg A. ANDREEV (Saunderstown, Rhode Island); Donald M. ENGELMAN (New Haven, Connecticut) |
| ABSTRACT | Provided herein are, inter alia, pH-triggered compounds and compositions comprising one or more peptides that are capable of inserting into a lipid bilayer below a certain pH. Treatment, imaging, diagnostic, and other uses of such compounds and compositions are also provided. |
| FILED | Thursday, June 08, 2023 |
| APPL NO | 18/331904 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 47/42 (20130101) A61K 47/64 (20170801) A61K 47/65 (20170801) A61K 49/0056 (20130101) Original (OR) Class Peptides C07K 7/06 (20130101) C07K 14/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/84 (20130101) G01N 2033/0003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042068 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min Chen (Stanford, California); Yunfeng Cheng (Stnaford, California); Jianghong Rao (Stanford, California); Zixin Chen (Stanford, California); Jinghang Xie (Fremont, California) |
| ABSTRACT | Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe. |
| FILED | Monday, June 05, 2023 |
| APPL NO | 18/329245 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/088 (20130101) Original (OR) Class Peptides C07K 5/101 (20130101) C07K 5/1021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042101 | DeForest et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Cole DeForest (Seattle, Washington); Ivan Batalov (Seattle, Washington); Kelly Rose Stevens (Seattle, Washington) |
| ABSTRACT | Materials, methods, and systems for biorthogonal ligation of hydrogel labels to crosslinked-natural polymer hydrogels are provided. A heterobifunctional linker includes a peptide-reactive activated functional group on the heterobifunctional linker, including an activated amine-reactive functional group, an activated thiol-reactive functional group and being reactive with a hydrogel comprising a crosslinked natural polymer. The heterobifunctional linker also includes a photocaged reactive group including a photocaged hydroxylamine, a photocaged alkoxyamine, a photocaged hydrazide, a photocaged amine, a photocaged tetrazine, or a photocaged alkyne-containing moiety. The peptide-reactive activated functional group does not include an azide. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 18/258735 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Original (OR) Class Heterocyclic Compounds C07D 207/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042161 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lu Li (Pittsburgh, Pennsylvania); Michael B. Schwerin (Pittsburgh, Pennsylvania); Howie Choset (Pittsburgh, Pennsylvania); Keith E. Cook (Pittsburgh, Pennsylvania); Jason Rose (Blawnox, Pennsylvania) |
| ABSTRACT | Provided is a system for operating a ventilator. The system includes a motorized proportional valve actuator including a stepper motor and an actuator. The actuator is connected to the stepper motor and configured to output pressurized air by controlling a pressure on a valve diaphragm. A conduit provides for fluid communication of the pressurized air to a breathing apparatus. A sensor arrangement is in fluid communication with the conduit between the at least one motorized proportional valve actuator and the breathing apparatus. The sensor arrangement includes: (i) an intake manifold configured to output a restricted flow of air from the pressurized air transported in the conduit, and (ii) a sensor device in fluid communication with an outlet of the intake manifold, the sensor device configured to measure an air pressure of the conduit based on the restricted flow of air. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 18/245936 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/204 (20140204) Original (OR) Class A61M 16/205 (20140204) A61M 16/1005 (20140204) A61M 2016/0027 (20130101) A61M 2205/3372 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042194 | Frank et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loren M. Frank (San Anselmo, California); Jason Chung (Oakland, California) |
| ABSTRACT | The present disclosure generally provides methods of implanting an implantable device in contact with a brain of a subject. Also provided are kits and systems for the implantation of one or more implantable devices. |
| FILED | Tuesday, May 02, 2023 |
| APPL NO | 18/142279 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/6868 (20130101) A61B 17/3468 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101) Original (OR) Class A61N 1/0539 (20130101) A61N 1/37223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042206 | Halpern et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Casey Halpern (Menlo Park, California); Robert C. Malenka (Palo Alto, California); Hemmings Wu (Palo Alto, California) |
| ABSTRACT | The present invention provides, inter alia, methods, apparatus, and systems useful for ameliorating impulse control disorders known to be extremely disabling and common to many neurological and psychiatric conditions using closed-loop (responsive) neuro stimulation. |
| FILED | Wednesday, March 22, 2023 |
| APPL NO | 18/188120 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4064 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/05 (20130101) A61N 1/0529 (20130101) A61N 1/36085 (20130101) Original (OR) Class A61N 1/36089 (20130101) A61N 1/36139 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042211 | Tai |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changfeng Tai (Wexford, Pennsylvania) |
| ABSTRACT | Provided herein is a method of blocking a nerve or neuron by applying an electrical stimulation to the nerve or neuron, wherein the electrical stimulation is of an intensity below the excitation threshold of the nerve or neuron for a length of time sufficient to produce a block of nerve conduction or neuron excitation. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/490822 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101) A61N 1/36062 (20170801) A61N 1/36071 (20130101) A61N 1/36153 (20130101) A61N 1/36157 (20130101) A61N 1/36164 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042425 | Abate et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam R. Abate (San Francisco, California); Jesse Qiuxu Zhang (San Francisco, California); Leqian Liu (San Francisco, California); Cyrille L. Delley (San Francisco, California); Russell Cole (San Francisco, California); Christian Siltanen (San Francisco, California) |
| ABSTRACT | Provided is a method of generating droplets that includes aspirating a first liquid into a tube, positioning the tube over a receiving liquid, and ejecting the first liquid to generate a plurality of droplets that contact the receiving liquid and remain discrete even after contacting the receiving liquid. Whereas many other droplet generators require complex microfluidics, the present methods allow generation of droplets without the need for microfluidics. The methods can be performed with existing commercially available macro-fluidic liquid handling devices. The methods can be used for digital PCR, digital MDA, enzyme screening, single cell analysis, and other applications involving droplets. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 18/027298 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0268 (20130101) Original (OR) Class B01L 2400/0436 (20130101) B01L 2400/0439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043373 | John et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Varghese John (Los Angeles, California); Jesus J. Campagna (Playa Del Rey, California); Sujyoti Chandra (Los Angeles, California); Samuel W. Johnson-Cohn (Los Angeles, California); Barbara Jagodzinska (Los Angeles, California) |
| ABSTRACT | The present disclosure relates to compounds that are capable of upregulating sAPPα and/or stabilizing reticulon-3. The disclosure further relates to methods of treating neurodegenerative diseases and disorders (e.g., Alzheimer's disease). |
| FILED | Friday, August 27, 2021 |
| APPL NO | 18/023594 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Acyclic or Carbocyclic Compounds C07C 237/20 (20130101) Original (OR) Class C07C 2601/16 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043384 | CZAKO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barbara CZAKO (Bellaire, Texas); William RALVENIUS (Somerville, Massachusetts); Li-Huei TSAI (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are compounds which inhibit PU.1, pharmaceutical formulations, and methods of treatment of PU.1-mediated diseases, such as Alzheimer's disease, inflammation, and diseases related to excessive myelin uptake. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/481451 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/42 (20130101) Original (OR) Class C07D 213/61 (20130101) C07D 213/73 (20130101) C07D 213/75 (20130101) C07D 217/02 (20130101) C07D 231/56 (20130101) C07D 401/12 (20130101) C07D 405/12 (20130101) C07D 409/12 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043390 | Nathanson et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Nathanson (Los Angeles, California); Wilson X. Mai (Sunnyvale, California); Michael E. Jung (Los Angeles, California); Peter M. Clark (Los Angeles, California); Timothy F. Cloughesy (Calabasas, California); Gyudong Kim (Seoul, South Korea); Johathan Tsang (Los Angeles, California); Lorenz Urner (Los Angeles, California) |
| ABSTRACT | The present disclosure relates to compounds that are capable penetrating to the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR mediated cancers. The disclosure further relates to methods of treating glioblastoma and other EGFR mediated cancers that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200265 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/496 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 239/95 (20130101) Original (OR) Class C07D 405/10 (20130101) C07D 491/056 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/57407 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043394 | Tepe et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jetze J. Tepe (East Lansing, Michigan); Sophia Staerz (Lansing, Michigan) |
| ABSTRACT | Described herein are chlorpromazine, methods for making such compounds, and the use of such compounds in the treatment of cancer, an inflammatory disease or condition or neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and ALS. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 18/041193 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/327 (20130101) C07D 209/88 (20130101) C07D 233/64 (20130101) C07D 235/26 (20130101) C07D 265/36 (20130101) C07D 265/38 (20130101) C07D 279/28 (20130101) Original (OR) Class C07D 295/192 (20130101) C07D 471/04 (20130101) C07D 473/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043417 | Ghosh et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Hiroaki Mitsuya (Kumamoto, Japan); Andrew Mesecar (West Lafayette, Indiana) |
| ABSTRACT | Bis-amide inhibitors of SARS-CoV-2 (COVID) and methods of using them to treat a severe acute respiratory syndrome. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 18/255339 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 413/14 (20130101) C07D 417/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043422 | Graci et al. |
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| FUNDED BY |
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| APPLICANT(S) | PTC Therapeutics, Inc. (South Plainfield, New Jersey) |
| ASSIGNEE(S) | PTC Therapeutics, Inc. (South Plainfield, New Jersey) |
| INVENTOR(S) | Jason D. Graci (West Orange, New Jersey); Zhengxian Gu (Las Vegas, Nevada) |
| ABSTRACT | Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections, involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments. |
| FILED | Friday, March 24, 2023 |
| APPL NO | 18/126198 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/437 (20130101) A61K 31/4745 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043438 | Ghosh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arun K. Ghosh (West Lafayette, Indiana); William Lewis Robinson (Taft, Tennessee); Shivaji Markad (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); William Lewis Robinson (Taft, Tennessee); Shivaji Markad (West Lafayette, Indiana) |
| ABSTRACT | A method for making an optically active P2-ligand precursor comprising converting D-xylose or a derivative thereof or D-glucose or a derivative thereof to the optically active P2-ligand precursor. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 18/041072 |
| CURRENT CPC | Heterocyclic Compounds C07D 493/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043440 | Markowitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford Markowitz (Pepper Pike, Ohio); Monika Antczak (Fort Worth, Texas); Joseph Ready (Carrollton, Texas); Yongyou Zhang (Cleveland, Ohio) |
| ABSTRACT | Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 18/057589 |
| CURRENT CPC | Heterocyclic Compounds C07D 495/04 (20130101) Original (OR) Class C07D 495/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043443 | Markowitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford Markowitz (Pepper Pike, Ohio); James K.V. Willson (Dallas, Texas); Bruce Posner (Richardson, Texas); Joseph Ready (Carrollton, Texas); Yongyou Zhang (Cleveland, Ohio); Hsin-Hsiung Tai (Lexington, Kentucky); Monica Antczak (Ft. Worth, Texas); Stanton Gerson (Hunting Valley, Ohio); KiBeom Bae (Buk-gu, South Korea); Sung Yeun Yang (Yeonje-Gu, South Korea); Amar Desai (Cleveland, Ohio) |
| ABSTRACT | Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein. |
| FILED | Monday, July 31, 2023 |
| APPL NO | 18/228452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 31/4365 (20130101) Acyclic or Carbocyclic Compounds C07C 311/21 (20130101) C07C 2601/14 (20170501) Heterocyclic Compounds C07D 207/263 (20130101) C07D 209/08 (20130101) C07D 213/71 (20130101) C07D 213/73 (20130101) C07D 213/75 (20130101) C07D 213/76 (20130101) C07D 215/08 (20130101) C07D 237/20 (20130101) C07D 239/42 (20130101) C07D 241/20 (20130101) C07D 261/14 (20130101) C07D 275/03 (20130101) C07D 277/46 (20130101) C07D 295/185 (20130101) C07D 405/12 (20130101) C07D 495/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043470 | LIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York); TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gang LIN (Forest Hills, New York); Carl NATHAN (Larchmont, New York); Laura KIRKMAN (New York, New York); Wenhu ZHAN (Elmhurst, New York); Trevor MORGAN (Royston, United Kingdom); Kenjiro SATO (Fujisawa, Japan); Ryoma HARA (Tokyo, Japan); Masanori KAWASAKI (Tokyo, Japan); Toshihiro IMAEDA (Fujisawa, Japan); Akinori TOITA (Minami-ku, Japan); Rei OKAMOTO (Yokohama, Japan); Takafumi YUKAWA (Yokohama, Japan); Kazuyoshi ASO (Yokohama, Japan); Tzu-Tshin WONG (Acton, Massachusetts); John D. GINN (New Milford, Connecticut); Michael A. FOLEY (New York, New York) |
| ABSTRACT | The compounds of the present invention are represented by the following compounds having Formula I and Formula (I′): where the substituents R1, R2, R2′, R3, R4, R5, R′, R″, X, Y, and Z are as defined herein and where the substituents R1, R2, R3, R4, R5, R′, R″, X, Y, and Z are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/473846 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 5/0215 (20130101) Original (OR) Class C07K 11/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043480 | Joglekar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ajit P. Joglekar (Ann Arbor, Michigan); Pavithra Aravamudhan (Nashville, Tennessee) |
| ABSTRACT | Provided herein are compositions and methods for the treatment of cancer by activating the spindle assembly checkpoint (SAC) in cells. In particular, dimerized Mps1 and Spc105/KNL1 constructs are provided as tunable activators of SAC, allowing for control of chromosome segregation accuracy and prevention of aneuploidies that are common in cancer. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/175303 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Enzymes C12Y 207/12002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043493 | WEISS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. WEISS (Indianapolis, Indiana); Nelson B. PHILLIPS (Seven Hills, Ohio); Faramarz ISMAIL-BEIGI (Shaker Heights, Ohio) |
| ABSTRACT | A single-chain insulin analogue comprises the insulin B-chain polypeptide sequence, the insulin A-chain polypeptide sequence, and a connecting polypeptide sequence of 5-11 amino acids linking the C-terminal amino acid of the B-chain polypeptide to the N-terminal amino acid of the A-chain polypeptide. The analogue comprises an acetylated Lys at a location selected from the group consisting of any of the amino acids in the connecting polypeptide, B0-B3, B28-B29 or A14, relative to wild type insulin, or comprises an acetylated amino acid at the N-terminal amino acid of the single-chain insulin analogue. The single-chain insulin analogue may be acylated with a C6-C21 fatty acid, which may be attached to the e-amino group of a unique Lysine residue or the a-amino group of the N-terminal amino acid of the single-chain insulin analogue. The insulin analogue may be used to lower the blood sugar of a patient in need thereof. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 18/265616 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 14/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043504 | Baum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regeneron Pharmaceuticals, Inc. (Tarrytown, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alina Baum (Pleasantville, New York); Benjamin Fulton (New York, New York); Christos Kyratsous (Irvington, New York); George D. Yancopoulos (Yorktown Heights, New York) |
| ABSTRACT | The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections). |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/927649 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/1003 (20230801) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043512 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ImCare Biotech, LLC (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanyong Lu (Horaham, Pennsylvania); Felix LU (Burbank, California) |
| ABSTRACT | Two classes of anti-AS-SPIK antibodies that specifically bind to one of two different conformational epitopes are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to diagnose and/or treat disorders characterized by the expression of AS-SPIK (e.g., liver cancer). Diagnostic methods and kits comprising the anti-AS-SPIK antibodies are also disclosed. |
| FILED | Tuesday, August 18, 2020 |
| APPL NO | 17/641780 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/31 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043520 | Cheung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Kevin Cheung (Mercer Island, Washington); Ami Yamamoto (Seattle, Washington); Brad Krajina (Shoreline, Washington); Yin Huang (Bothell, Washington) |
| ABSTRACT | Provided herein are methods to reduce tumor cell proliferation in a cancer patient by administering an antibody that binds angiopoietin-like 7, wherein administering the angiopoietin-like 7 antibody can reduce necrosis formation, metastasis formation, and circulating tumor cells. |
| FILED | Thursday, August 03, 2023 |
| APPL NO | 18/365110 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/22 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043534 | KOSSIAKOFF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Anthony KOSSIAKOFF (Chicago, Illinois); Tomasz SLEZAK (Chicago, Illinois); Elena DAVYDOVA (Chicago, Illinois); Edwin ARAUZ-DIAZ (Chicago, Illinois) |
| ABSTRACT | The engineered polypeptide comprising modified Fab constant regions and/or protein G Fab binding domains provide advanced affinity reagents that can be used in cell biology applications as well as for therapeutic applications. Accordingly, aspects of the disclosure relate to a polypeptide comprising a constant region of an antibody light chain, wherein the constant region comprises a substitution/deletion of amino acids corresponding to positions 16-20 of SEQ ID NO:1 of the constant region with the amino acids LRT. |
| FILED | Wednesday, October 14, 2020 |
| APPL NO | 17/754797 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2803 (20130101) C07K 16/2809 (20130101) Original (OR) Class C07K 16/2887 (20130101) C07K 2317/52 (20130101) C07K 2317/55 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043541 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Novartis AG (Basel, Switzerland); The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryon Duane Johnson (Jackson, Wisconsin); Robert Millman (Boston, Massachusetts) |
| ABSTRACT | The present invention relates to methods of treating hematologic cancers using a combination of inhibitors of PD-1 or PD-L1 and TIM-3, LAG-3 or CTLA4. |
| FILED | Wednesday, May 31, 2023 |
| APPL NO | 18/326373 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39558 (20130101) A61K 47/6849 (20170801) A61K 51/1096 (20130101) A61K 2039/507 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Peptides C07K 16/2803 (20130101) C07K 16/2818 (20130101) C07K 16/2827 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043806 | COULOMBE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kareen L. K. COULOMBE (Pawtucket, Rhode Island); Rajeev J. KANT (Providence, Rhode Island); Kiera D. DWYER (Providence, Rhode Island) |
| ABSTRACT | The invention provides a dual remuscularization-revascularization therapy comprising vascularized engineered human myocardial tissues (vEHMs). |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/358808 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) Original (OR) Class C12N 2502/28 (20130101) C12N 2502/45 (20130101) C12N 2539/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043809 | Cadwell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ken H. Cadwell (Forest Hills, New York) |
| ABSTRACT | The invention provides methods for administering necroptosis or interferon signaling inhibitors for treating or preventing immune-related tissue injury in a subject having an inactivating mutation in ATG16L1. The invention also provides organoid cultures and co-cultures and methods of use for identifying therapeutic agents. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/484008 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/37 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0679 (20130101) Original (OR) Class C12N 2501/11 (20130101) C12N 2501/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043815 | Sherman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David H. Sherman (Ann Arbor, Michigan); Amy E. Fraley (Ann Arbor, Michigan); Ashootosh Tripathi (Ypsilanti, Michigan) |
| ABSTRACT | The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals. |
| FILED | Monday, May 15, 2023 |
| APPL NO | 18/317683 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4995 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/182 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043818 | MASTOVICH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tim John MASTOVICH (Boston, Massachusetts); Michael FITZGERALD (Santa Clara, California); Jessie Lyn GIFFORD (Boston, Massachusetts); Andrew C. HOROWITZ (Mansfield, Massachusetts); Megan Jayne POWELL (Malden, Massachusetts); Jeffrey William RUBERTI (Lexington, Massachusetts) |
| ABSTRACT | Cells for increased collagen production are engineered by a novel CRISPR cellular engineering process. The process can be carried out using human cells or even patient-harvested cells. Collagen produced by the cells has a low risk of immunogenicity when implanted into human patients compared to collagen produced by non-human cells. Cell culture media including chemical additives are also provided to have a further positive effect on collagen production. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 18/031486 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/65 (20130101) A61K 38/39 (20130101) A61K 2800/10 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 26/0033 (20130101) A61L 27/24 (20130101) A61L 2430/02 (20130101) A61L 2430/16 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043823 | PTACIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Synthorx, Inc. (Cambridge, Massachusetts); The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | Synthorx, Inc. (Cambridge, Massachusetts); The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Jerod PTACIN (La Jolla, California); Carolina CAFFARO (La Jolla, California); Hans AERNI (La Jolla, California); Yorke ZHANG (La Jolla, California); Emil C. FISCHER (La Jolla, California); Aaron W. FELDMAN (La Jolla, California); Vivian T. DIEN (La Jolla, California); Floyd E. ROMESBERG (La Jolla, California) |
| ABSTRACT | Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/481086 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/90 (20130101) C12N 15/113 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043825 | Bailey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); University of Rochester (Rochester, New York) |
| INVENTOR(S) | Michael R. Bailey (Seattle, Washington); Adam D. Maxwell (Seattle, Washington); Mohamed Abdalla Ghanem (Seattle, Washington); Diane Dalecki (Rochester, New York) |
| ABSTRACT | Methods and systems for creating patterns in tissue growth for tissue engineering are disclosed. In one embodiment, a method for arranging biological cells along predetermined patterns using an ultrasound includes: emitting the ultrasound by an ultrasound transducer; transmitting the ultrasound through a holographic lens toward a plurality of cells; and generating a pressure field in the predetermined patterns. The predetermined pattern includes a plurality of mutually parallel transverse planes. The parallel transverse planes are configured to entrap groups of cells of the plurality of cells. The axial pressure gradients within the parallel transverse planes are smaller than a first predetermined threshold. The lateral pressure gradients within the parallel transverse planes are larger than a second predetermined threshold. In response to generating the pressure field, the groups of entrapped cells are aligned within parallel transverse planes. |
| FILED | Thursday, August 03, 2023 |
| APPL NO | 18/365094 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043828 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Alim Ladha (Cambridge, Massachusetts) |
| ABSTRACT | Described in several embodiments herein are compositions, systems, and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Described in several embodiments are nucleic acid targeting systems that include components of CRISPR systems, VirD polypeptide(s), and DNA polymerase(s). |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 18/030324 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1252 (20130101) C12N 15/11 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2310/20 (20170501) Enzymes C12Y 207/07007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043835 | Barna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Maria Barna (Stanford, California); Kathrin Leppek (Stanford, California) |
| ABSTRACT | Systems, methods, and kits for enhancing mRNA translation are disclosed. Some embodiments describe expression constructs for producing a peptide and include a translational enhancer. Additional embodiments describe methods for producing a peptide using a construct including a translational enhancer. Certain embodiments further enhance mRNA stability. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/998788 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043838 | Beutler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Bruce Beutler (Dallas, Texas); Evan D. Nair-Gill (Dallas, Texas) |
| ABSTRACT | Compositions and methods for attenuating or preventing lymphoproliferation in a subject are provided. The subject may have, be suspected of having, or at risk of having a lymphoproliferative disease. The methods herein include administering to the subject a composition effective for decreasing WD repeat domain protein 37 (Wdr37) expression and/or activity. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 18/265226 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043839 | TABAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ira TABAS (New York, New York); Xiaobo WANG (New York, New York) |
| ABSTRACT | The present invention relates to methods and compositions for using plasma Indian hedgehog (IHH) as a biomarker for diagnosing, and as a therapeutic target for treating, liver conditions including non-alcoholic steatohepatitis (NASH). |
| FILED | Thursday, April 13, 2023 |
| APPL NO | 18/299799 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043840 | Sanjana et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York Genome Center, Inc. (New York, New York); New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neville E. Sanjana (New York, New York); Hans-Hermann Wessels (Brooklyn, New York); Alejandro Mendez-Mancilla (Brooklyn, New York); Mateusz Legut (Jersey City, New Jersey) |
| ABSTRACT | Provided herein are compositions and methods comprising modified crRNA comprising a spacer sequence and a direct repeat sequence, wherein the crRNA comprises one or more chemically modified nucleotides. Also provided are methods of enhancing modulation of gene transcripts in a cell, the method comprising introducing into the cell a modified crRNA as described herein, and a Cas13 polypeptide, an mRNA encoding a Cas13 polypeptide, and/or a recombinant expression vector comprising a nucleotide sequence encoding a Cas13 polypeptide, wherein the modified crRNA guides the Cas13 polypeptide to the target RNA sequence, and wherein the modified crRNA induces regulation of the target RNA with an enhanced activity relative to a corresponding unmodified crRNA. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 18/257504 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/1131 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/315 (20130101) C12N 2310/317 (20130101) C12N 2310/344 (20130101) C12N 2310/346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240043842 — MUSCLE RETENTION IN AGING AND DUCHENNE MUSCULAR DYSTROPHY (DMD) THROUGH S1P INHIBITION
| US 20240043842 | Brookheart |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Rita Brookheart (St. Louis, Missouri) |
| ABSTRACT | Methods are provided of reversing muscle loss and improving mitochondrial function via site-1 protease (S1P) inhibition. Further methods are provided for treating Duchenne muscular dystrophy and age-related muscle loss via site-1 protease (S1P) inhibition. |
| FILED | Tuesday, August 08, 2023 |
| APPL NO | 18/231684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043848 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tingting Yang (New York, New York); Stephen H. Tsang (New York, New York); Yu Zhang (New York, New York) |
| ABSTRACT | The present disclosure relates to methods, compositions, and systems for rescuing gene function and the treatment and prevention of a disease or disorder (e.g., bestrophinopathies). |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485930 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/85 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2710/14043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043849 | Chan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Ying Kai Chan (Cambridge, Massachusetts); George M. Church (Cambridge, Massachusetts) |
| ABSTRACT | Modified viral genomes are able to reduce induction of inflammatory and immune antiviral responses. This manifests itself in reduced NF-kB activity, increased viral transduction rates, and increased expression of transgenes. Viral genomes are modified by incorporating one or more oligonucleotide sequences which are able to bind to TLR9 but not induce activation of it. The oligonucleotide sequences may be synthetic, bacterial, human, or from any other source. |
| FILED | Friday, June 09, 2023 |
| APPL NO | 18/332109 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 35/76 (20130101) A61K 45/06 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/117 (20130101) Original (OR) Class C12N 2310/17 (20130101) C12N 2330/51 (20130101) C12N 2750/00032 (20130101) C12N 2750/00041 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043893 | Weitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Huidan Zhang (Cambridge, Massachusetts); John Heyman (Cambridge, Massachusetts); Allon Moshe Klein (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets or other compartments, for instance, arising from a cell. In one set of embodiments, particles may be prepared containing oligonucleotides that can be used to determine target nucleic acids, e.g., attached to the surface of the particles. The oligonucleotides may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together or removed from the droplets. Certain embodiments of the invention are generally directed to systems and methods for attaching additional or arbitrary sequences to the nucleic acids within microfluidic droplets or other compartments, e.g., recognition sequences that can be used to selectively determine or amplify a desired sequence suspected of being present within a droplet. Such systems may be useful, for example, for selective amplification in various applications, such as high-throughput sequencing applications. |
| FILED | Friday, July 14, 2023 |
| APPL NO | 18/353058 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1006 (20130101) C12N 15/1065 (20130101) C12N 15/1093 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043899 | Sun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SYNVITROBIO, INC. (San Leandro, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary Z. Sun (San Leandro, California); Abel C. Chiao (San Leandro, California); Dan E. Robertson (San Leandro, California); Louis E. Metzger (San Leandro, California); Richard Mansfield (San Leandro, California); Kelly S. Trego (San Leandro, California) |
| ABSTRACT | Provided herein, in one aspect, is a composition for in vitro transcription and translation, comprising: a treated cell lysate derived from one or more host cells such as bacteria, archaea, plant or animal; a plurality of supplements for gene transcription and translation; an energy recycling system for providing and recycling adenosine triphosphate (ATP); and one or more exogenous additives. Methods for making and using the same are also provided. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/320389 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 207/07006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043915 | Macosko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | Evan Macosko (Boston, Massachusetts); Nicolas Lapique (Cambridge, Massachusetts); Michael Kim (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods for detecting nucleic acid sequences (e.g., coding and non-coding RNAs; nuclear/genomic DNA; mtDNA; pathogen nucleic acids, etc.) in a tissue sample, specifically providing improved matrices and matrix-employing methods for performance of nucleic acid capture and amplification in a tissue sample in situ and/or in a manner that retains spatial location information for captured nucleic acids (including nucleic acid-associated macromolecules). |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/546173 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043917 | Bick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander G. Bick (Nashville, Tennessee); Angela Jones (Nashville, Tennessee) |
| ABSTRACT | Disclosed herein is a scalable multiplex method for amplifying a plurality of target DNA regions collectively 1 kb to 100 kb in size in a plurality of samples. Also disclosed herein is a scalable multiplex method for identifying a subject with increased risk of developing a cardiometabolic disease or a hematological cancer that involves amplifying and sequencing target DNA regions corresponding to the genes DNMT3A, TET2, ASXL1, JAK2, GNAS, GNB, CBL, TP53, PPM1D, SF3B1, SRSF2, PIGA, BCOR, BCORL1, DNMT3A, and ASXL1 from a plurality of DNA samples according to the method disclosed herein, and identifying from said sequencing one or more mutations in one or more of the genes, wherein presence of said mutation(s) indicates an increased risk of developing a cardiometabolic disease and/or a hematological cancer. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/361068 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6855 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043931 | Rus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Horea G. Rus (Catonsville, Maryland); Freidrich ANSELMO (Germantown, Maryland); Alexandru TATOMIR (Baltimore, Maryland) |
| ABSTRACT | A MS disease activity (MSDA) score is provided as a tool to detect relapse and response to glatiramer acetate (GA) therapy in subjects having relapsing-remitting multiple sclerosis (RRMS) using the blood-based biomarkers SIRT1, RGC-32, FasL, IL-21, pSIRT1 and JNK p54. |
| FILED | Thursday, August 03, 2023 |
| APPL NO | 18/364581 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2800/52 (20130101) G01N 2800/60 (20130101) G01N 2800/285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043936 | HARICHARAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Svasti HARICHARAN (San Diego, California) |
| ABSTRACT | Described herein are methods of prognosing/diagnosing an estrogen receptor positive (ER+) breast cancer in an African American subject. Also described herein are methods of treating an estrogen receptor positive (ER+) breast cancer in an African American subject. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 18/251045 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043943 | Alavi Khorassani Moghadam |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | 712 NORTH, INC. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcel V Alavi Khorassani Moghadam (Berkeley, California) |
| ABSTRACT | The present invention relates to a reporter for measuring OMA1 protease activity comprising a targeting sequence and a signal producing domain, wherein the targeting sequence is also the sequence recognized by OMA1. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 18/019802 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) C12Q 1/6897 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044048 | Bloom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jesse Bloom (Seattle, Washington); Allison Greaney (Seattle, Washington); Andrea Loes (Seattle, Washington); Adam S. Dingens (Seattle, Washington) |
| ABSTRACT | Methods to create barcoded influenza viruses without disrupting the function of the viral proteins and the proper packaging of the viral genome segments are described. The barcoded influenza viruses can be used within deep mutational scanning libraries to map influenza resistance mutations to therapeutic treatments. The libraries can also be used to predict influenza strains that may become resistant to therapeutic treatments and/or more easily evolve to infect new species. The libraries include features that allow efficient collection and assessment of informative data, obviating bottlenecks of previous approaches. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/490591 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/1065 (20130101) C12N 2760/16021 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 50/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044873 | Birnbaum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael Birnbaum (Arlington, Massachusetts); Connor Dobson (Somerville, Massachusetts) |
| ABSTRACT | Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458628 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/4748 (20130101) C07K 14/5437 (20130101) C07K 14/70532 (20130101) C07K 14/70539 (20130101) C07K 16/2803 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/035 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15045 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044895 | ONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Irene ONG (Fitchburg, Wisconsin); David O’CONNOR (Madison, Wisconsin); Miriam SHELEF (Madison, Wisconsin); Anna HEFFRON (Madison, Wisconsin); David BAKER (Northbrook, Illinois); Maya AMJADI (Madison, Wisconsin); Sean MCILWAIN (Madison, Wisconsin); Saniya KHULLAR (West Windsor, New Jersey) |
| ABSTRACT | The present invention is directed to peptides for use in the detection of antibodies against SARS-CoV-2, which are indicative of past SARS-CoV-2 infections. Additionally, assays and methods of distinguishing patients having had a prior infection from those vaccinated patients are also provided. Additionally, vaccine compositions for use in eliciting anti-SARS-CoV-2 immune response are provided along with methods of producing antibodies and methods of eliciting an immune response. |
| FILED | Monday, September 20, 2021 |
| APPL NO | 18/245868 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Peptides C07K 14/165 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/76 (20130101) G01N 33/543 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044898 | Konstantopoulos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Konstantinos Konstantopoulos (Ellicott City, Maryland); Colin Paul (Catonsville, Maryland); Alfredo Quinones-Hinojosa (Ponte Vedra Beach, Florida); Sagar Ramesh Shah (Clemson, South Carolina); Alejandro Ruiz-Valls (Baltimore, Maryland); Christopher Yankaskas (Baltimore, Maryland); Juan Carlos Martinez-Gutierrez (Baltimore, Maryland); Bin Sheng Wong (Baltimore, Maryland) |
| ABSTRACT | The present invention describes an integrated apparatus that enables identification of invasive tumor cells directly from a specimen. The methods using the apparatus can be used to prognose or predict the survivability of the cancer in a subject and the risk of recurrence of the cancer in the subject after treatment. The methods disclosed herein can be used to determine which chemotherapeutic or other therapies most strongly inhibit the tumor cells invasiveness as a form of personalized therapy. |
| FILED | Wednesday, August 09, 2023 |
| APPL NO | 18/446969 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/0652 (20130101) B01L 2300/0816 (20130101) B01L 2300/0867 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) Original (OR) Class G01N 33/5011 (20130101) G01N 33/5029 (20130101) G01N 33/5091 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044900 | Risom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyler Risom (Redwood City, California); Robert B. West (Menlo Park, California); Robert M. Angelo (Stanford, California) |
| ABSTRACT | Compositions and methods are provided for stratification of ductal carcinoma in situ (DCIS) tumors with respect to prognostic features that distinguish primary DCIS tumors with a high probability of recurrence and invasive disease, representing tumor progression, from tumors that will not recur. Stratification methods may comprise analysis of a DCIS tissue sample with MIBI-TOF imaging. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 18/265661 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/0004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044915 | Zhao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ann and Robert H. Lurie Children's Hospital of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Youyang Zhao (Deerfield, Illinois) |
| ABSTRACT | Disclosed herein are methods for diagnosing and treating sepsis, acute respiratory distress syndrome (ARDS), and severe COVID-19 and associated ARDS, and also for treating elderly patients with ARDS induced by sepsis, pneumonia, and COVID-19. The disclosed methods utilize stromal cell-derived factor 1 (SDF1, also known as CXCL12) and the expression level thereof as a biomarker for diagnosing or treating sepsis, ARDS and severe and critical COVID-19. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 18/258440 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2333/521 (20130101) G01N 2800/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044922 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingjun Wang (Lexington, Kentucky); Sidney W. Whiteheart (Lexington, Kentucky); Ya Luo (Saratoga, Florida); Kanakanagavalli Shravani Prakhya (Lexington, Kentucky) |
| ABSTRACT | This disclosure relates to systems and methods for the observation and/or measurement of clot formation and/or contraction. The system includes reaction chambers arranged with an image capturing device to allow for quantification of clot side-view cross-sectional area over time to determine the kinetics of clot formation and/or contraction. By varying the cellular materials and test agents included in the reaction chambers, it is possible to determine the effect of any particular component may yield on clot contraction. The system provides low-cost set-up, robust software, and multi-sample capacity, thus is a sensitive and flexible system to be used as a “workhorse” tool in a regular laboratory setting for better understanding the molecular features of how platelets mediate clot contraction, with the potential for clinical usages and/or medium throughput laboratory testing and drug screens. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345803 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 3/502715 (20130101) B01L 2200/16 (20130101) B01L 2300/069 (20130101) B01L 2300/168 (20130101) B01L 2300/0654 (20130101) B01L 2300/0825 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240045043 | Oelze et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Oelze (Mahomet, Illinois); Pengfei Song (Champaign, Illinois); Zhengchang Kou (Champaign, Illinois) |
| ABSTRACT | Systems and methods for ultrafast imaging include: a memory having stored thereon a delay profile matrix and a field programmable gate array (FPGA) coupled with the memory. The delay profile matrix comprises a two-dimensional matrix in which each row corresponds to a delay profile at a particular depth. The FPGA is configured to: acquire radio frequency (RF) ultrasound data from a subject; load a delay profile from the delay profile matrix to a memory buffer of the FPGA, wherein the delay profile corresponds to a particular depth; read a first row of the RF ultrasound data based on a first delay value of the delay profile; generate beamformed data at the particular depth by beamforming the first row of RF ultrasound data; and generate an image of the subject based on the beamformed data. |
| FILED | Friday, August 04, 2023 |
| APPL NO | 18/365777 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/52046 (20130101) Original (OR) Class G01S 7/52087 (20130101) G01S 7/52095 (20130101) G01S 15/8927 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240046464 | EPSTEIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Frederick H. EPSTEIN (Charlottesville, Virginia); Changyu SUN (Charlottesville, Virginia); Sona QADIMI (Charlottesville, Virginia); Yu WANG (Charlottesville, Virginia); UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederick H. EPSTEIN (Charlottesville, Virginia); Changyu SUN (Charlottesville, Virginia); Sona QADIMI (Charlottesville, Virginia); Yu WANG (Charlottesville, Virginia) |
| ABSTRACT | An exemplary method and system are disclosed that employ DENSE deep learning neural-network(s) trained with displacement-encoded imaging data (i.e., DENSE data) to estimate intramyocardial motion from cine MRI images and other cardiac medical imaging modalities, including standard cardiac computer tomography (CT) images, magnetic resonance imaging (MRI) images, echocardiogram images, heart ultrasound images, among other medical imaging modalities described herein. The DENSE deep learning neural-network(s) can be configured (trained) using (i) contour motion data from displacement-encoded imaging magnitude data as inputs to the neural network and (ii) displacement maps derived from displacement-encoded imaging phase images for comparison to the outputs of the neural network for neural network adjustments during the training. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/277500 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/246 (20170101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/20084 (20130101) G06T 2207/30048 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240046533 | Haldar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Justin Haldar (Alhambra, California); Daeun Kim (Los Angeles, California) |
| ABSTRACT | Systems and methods of image reconstruction are provided. A system may have a memory and a processor to receive data corresponding to magnetic resonance imaging coils and data corresponding to a region of interest within a field of view of the magnetic resonance imaging machine. By determining different weights to associate with virtualized magnetic resonance imaging coils, images may be reconstructed to favor signals associated with a region of interest and to disfavor interference associated with areas outside the region of interest. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 18/266233 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0037 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) G01R 33/5611 (20130101) G01R 33/56572 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) Original (OR) Class G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047011 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); David Arthur Scott (Cambridge, Massachusetts) |
| ABSTRACT | Embodiments disclosed herein provide methods for identifying new CRISPR loci and effectors, as well as different CRISPR loci combinations found in various organisms. Class-II CRISPR systems contain single-gene effectors that have been engineered for transformative biological discovery and biomedical applications. Discovery of additional single-gene or multicomponent CRISPR effectors may enhance existing CRISPR applications, such as precision genome engineering. Comprehensive characterization of CRISPR-loci may identify novel functional roles of CRISPR loci enabling new tools for biomedicine and biological discovery. CRISPR loci have enormous feature complexity, but classification of CRISPR loci has been focused on a small fraction of highly abundant features. Increased genome sequencing has enhanced the sampling of this feature complexity. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488691 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/231 (20230101) G06F 18/295 (20230101) G06F 18/2413 (20230101) Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/30 (20190201) G16B 20/50 (20190201) G16B 40/00 (20190201) Original (OR) Class G16B 40/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047033 | WANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | XIAOSONG WANG (SEWICKLEY, Pennsylvania) |
| ABSTRACT | Provided is a method of modelling a therapeutic response of a cancer cell or tumor, comprising: calculating a weight for each of a plurality of high-dimensional redundant multi-omics features that predict agent sensitivity or other clinical features based on statistical or machine learning methods; and calculating an integral genomic signature score for the cancer cell or tumor based on the weights, while algorithmically resolving the feature redundancy based on unlabeled genomic datasets for large cohorts of human tumors. Also provided is an iGenSig model for an agent that calculates the probability of response or resistance of a patient having a cancer or tumor to treatment with the agent. Also provided is a method for selecting a patient having a cancer or tumor for treatment with an agent. Further provided is a method of treating a patient having a cancer or tumor. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 18/257349 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2800/52 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047064 | Vincent et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Vincent (San Diego, California); Andrew D. McCulloch (San Diego, California) |
| ABSTRACT | A method may include generating, based on a plurality of electrophysiology simulations such as electrical and/or electromechanical activation maps, one or more atlases including an activation time (AT) atlas and a vectorcardiogram (VCG) atlas. The atlases may be generated by applying a dimensionality reduction technique to include one or more modes of variation present in the electrophysiology simulations. The atlases may be applied to match a clinical vectorcardiogram of a patient to a simulated vectorcardiogram associated with an activation map included in the electrophysiology simulations. At least one of a diagnosis or treatment for the patient may be determined based on the activation map. Related systems and computer program products are also provided. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 18/257265 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/319 (20210101) A61B 5/341 (20210101) A61B 5/367 (20210101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047071 | Vashishth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Deepak Vashishth (Glenmont, New York); Bowen Wang (Albany, New York) |
| ABSTRACT | A method of predicting bone fracture risk in a type 2 diabetes (“T2D”) patient includes: obtaining a plurality of averaged glycated hemoglobin (“HbA1c”) values for a plurality of T2D subjects over an observational period; binning the plurality of averaged HbA1c values into two predetermined categories; obtaining a plurality of total fracture incidences for the plurality of T2D subjects over a follow-up period; performing a plurality of linear regression model correlations between the binned HbA1c values and the plurality of total fracture incidences to determine a bone fracture rate prediction model; obtaining a measurement of an HbA1c value of the T2D patient; and analyzing the HbA1c value of the T2D patient with the bone fracture rate prediction model to determine the T2D patient's risk of bone fracture for a future period. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/216679 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4504 (20130101) A61B 5/7275 (20130101) A61B 5/14532 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047081 | Welch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Welch (Ann Arbor, Michigan); Hengshi Yu (Ann Arbor, Michigan) |
| ABSTRACT | The following relates generally to identifying perturbations (e.g., chemical perturbations, or genetic perturbations), drug treatments, and/or protein sequences. Some embodiments include a machine learning algorithm comprising a first network that converts perturbations into real-valued vector representations of the perturbations; a second network that converts cell states into real-valued vector representations of the cell states; and a third network that maps relationships between: (i) the real-valued vector representations of the perturbations, and (ii) the real-valued vector representations of the cell states. Some embodiments use the machine learning algorithm to identify a perturbation that will cause a starting cell state to transition to a target cell state by inputting the starting cell state and the target cell state into the machine learning algorithm. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876493 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 70/40 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240048823 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Spectral MD, Inc. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shuai Yu (Mansfield, Texas); Jason Dwight (Dallas, Texas); Hanh Le (Rockwall, Texas); Jeffrey E. Thatcher (Irving, Texas); Wensheng Fan (Plano, Texas) |
| ABSTRACT | The present technology comprises a single-aperture snapshot multi-spectral imaging device generally consisting of at least a color camera, a customized Octa-Band optical filter, a motorized zoom lens, and an 8-wavelength multi-color LED illumination system. The present technology also comprises a method about designing time sequences and combinations of LED illuminations, along with an unmixing algorithm for 8 MSI images generation. According to the present device and method, it is capable of fast multi-spectral image acquisition speed (<100 milliseconds), fast post-processing speed based on adopting a single aperture system without disparity correction calculation, adjustable FOVs, smaller form factors and lower costs, and high precision of spectral information. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470318 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/7264 (20130101) A61B 2576/00 (20130101) Pictorial Communication, e.g Television H04N 23/11 (20230101) Original (OR) Class H04N 23/55 (20230101) H04N 23/56 (20230101) H04N 23/84 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240049483 | Khademhosseini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Alireza Khademhosseini (Los Angeles, California); Shiming Zhang (Los Angeles, California) |
| ABSTRACT | A low power-consumption iontronic pressure sensor is disclosed that is based on OECT where an ionic hydrogel is used as solid gating medium for pressure sensing transistor elements formed thereon. The pressure sensor includes a substrate containing one or more pressure sensing transistor elements with each transistor element including a source electrode, a drain electrode, and a channel formed from a material comprising an electrically conducting polymer. A microstructured solid gel electrolyte having a plurality of microstructures formed thereon serves as the gating medium and is disposed atop the channel. A gate electrode is disposed on the microstructured solid gel electrolyte. The resultant iontronic pressure sensor may be operated at voltages less than 1 V, with a power-consumption between ˜101-103 μW, while maintaining a tunable sensitivity between 1˜10 kPa−1. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 18/042197 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/005 (20130101) Organic electric solid-state devices H10K 10/471 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240041150 | Torbati et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Impressio Inc. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amir H. Torbati (Westminster, Colorado); Lyssa A. Bell (Littleton, Colorado); Lillian S. Chatham (Lakewood, Colorado); Richard M. Wojcik (Denver, Colorado); Christopher M. Yakacki (Denver, Colorado); Risheng Zhou (Denver, Colorado) |
| ABSTRACT | A helmet for improved impact protection includes a shell and a first pad disposed within the shell. The first pad includes a first lattice structure with at least one LCE pillar. In some aspects, the helmet includes a plurality of pads. Each pad may include multiple regions. Each region of a pad may be comprised of different lattice structures, some of which contain LCE pillars and some of which do not. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/229090 |
| CURRENT CPC | Hats; Head Coverings A42B 3/125 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041404 | Omenetto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fiorenzo G. Omenetto (Lexington, Massachusetts); Giusy Giusy (Medford, Massachusetts); Gili Naveh (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure provides an oral sampling device for chemical examination of an oral cavity. The oral sampling device includes an oral sampling support substrate, and a bioresponsive interface coupled to the oral sampling support substrate. The bioresponsive interface is composed of a biopolymer matrix comprising a sensing agent. In some aspects, the bioresponsive interface undergoes a color change in response to an environmental parameter (e.g., pH value) in the region of interest in the oral cavity. |
| FILED | Friday, July 07, 2023 |
| APPL NO | 18/348717 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/682 (20130101) Original (OR) Class A61B 5/1468 (20130101) A61B 5/14507 (20130101) A61B 5/14539 (20130101) A61B 10/0051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041546 | Mondry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Mondry (Edina, Minnesota); Shane Farritor (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Thomas Frederick (Lincoln, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485601 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/20 (20160201) A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2017/2906 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0084 (20130101) B25J 9/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041859 | Mahjoub et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Mohamed 'Moe' Mahjoub (St. Louis, Missouri); Tao Cheng (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of a method of treating or preventing kidney disease in a subject in need thereof. Another aspect of the present disclosure provides for a method of reducing a number of kidney cells having excess centrosomes or centrosome amplification (CA) or inhibiting centrosome clustering in a subject having or suspected of having a kidney disease associated with CA or increased centrosome clustering. In some embodiments, the method comprises administering to the subject a centrosome clustering inhibiting agent. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 18/255655 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/473 (20130101) A61K 31/4745 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042001 | Tobin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Biological Mimetics, Inc. (Frederick, Maryland); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory J. Tobin (Frederick, Maryland); Taralyn J. Wiggins (Sharpsburg, Maryland); Michael J. Daly (Bethesda, Maryland); Elena Gaidamakova (Bethesda, Maryland); Vera Matrosova (Bethesda, Maryland) |
| ABSTRACT | Presented herein are inactivated A. baumannii immunogens. Also described herein are compositions including A. baumannii immunogens. Methods and compositions for preparing the same are also described. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 18/258842 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0208 (20130101) Original (OR) Class A61K 2039/522 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042018 | KRAFT II et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Cavin KRAFT II (Seattle, Washington); Isaac SAPPINGTON (Seattle, Washington); Neil P. KING (Seattle, Washington) |
| ABSTRACT | Polypeptides including the amino acid sequence of SEQ ID NO:78-80, substituted with one or more sequon, are provided, as are fusion proteins and nanoparticles formed from such polypeptides, and methods for their use. |
| FILED | Thursday, July 27, 2023 |
| APPL NO | 18/360190 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 2039/6031 (20130101) Peptides C07K 14/00 (20130101) C07K 2319/40 (20130101) C07K 2319/735 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042259 | Reddy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | V. Prakash Reddy (Rolla, Missouri); Puspa Aryal (Rolla, Missouri) |
| ASSIGNEE(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| INVENTOR(S) | V. Prakash Reddy (Rolla, Missouri); Puspa Aryal (Rolla, Missouri) |
| ABSTRACT | Agents for decontaminating and/or neutralizing organophosphorus compounds (e.g., nerve agents, pesticides) and methods of using those agents are disclosed. Preferred agents comprise aminoguanidine imines, and these agents do not require a strongly alkaline environment to be effective. The aminoguanidine imines can hydrolytically decontaminate substantially all of the target organophosphorus compound(s) in a matter of minutes. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363429 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/155 (20130101) A61K 31/417 (20130101) A61K 31/426 (20130101) Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/35 (20130101) Original (OR) Class A62D 2101/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042260 | DIXON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Warren E. DIXON (Gainesville, Florida); Kimberly J. Stubbs (Gainesville, Florida); Emily J. Griffis (Gainesville, Florida); Wanjiku A. Makumi (Gainesville, Florida); Hannah M. Sweatland (Gainesville, Florida); Tanja Taivassalo (Gainesville, Florida); Donovan Lott (Gainesville, Florida) |
| ABSTRACT | Provided herein is a method, apparatus, and system a motor-assisted stationary rehabilitation cycle employing a closed-loop control scheme. Methods may include: determining a desired set point rotational speed of a pair of pedals connected to a crankshaft; determining an upper bound and a lower bound about the desired set point rotational speed; determining a crankshaft rotational speed; increasing torque using a motor connected, at least indirectly, to the crankshaft in a first rotational direction, resisting rotation of the crankshaft in response to the rotational speed of the crankshaft approaching the upper bound; and increasing torque using the motor in a second rotational direction, opposite the first rotational direction in response to the rotational speed of the crankshaft approaching the lower bound. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/361276 |
| CURRENT CPC | Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 21/0058 (20130101) Original (OR) Class A63B 22/0605 (20130101) A63B 24/0062 (20130101) A63B 71/0622 (20130101) A63B 2024/0093 (20130101) A63B 2220/30 (20130101) A63B 2220/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042736 | SWAIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Greg M. SWAIN (Owosso, Michigan); Isuri N. DAMMULLA (East Lansing, Michigan) |
| ABSTRACT | An assembly that includes a first substrate formed of aluminum or an aluminum alloy; and a second substrate formed of a polymer composite that includes a plurality of carbon fibers. The second substrate is joined to the first substrate in a manner where a surface of exposed carbon fibers contacts the aluminum or aluminum alloy of the first substrate; and an is adlayer formed on the surface of the exposed carbon fibers that is configured to inhibit galvanic corrosion of the first substrate, corrosion of the carbon fibers, and debonding of the polymer of the composite from the carbon fibers upon formation of a galvanic couple between the first substrate and the second substrate. |
| FILED | Thursday, July 13, 2023 |
| APPL NO | 18/351624 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/12 (20130101) B32B 15/14 (20130101) Original (OR) Class B32B 15/20 (20130101) B32B 2255/02 (20130101) B32B 2255/26 (20130101) B32B 2260/021 (20130101) B32B 2260/046 (20130101) B32B 2262/106 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/54 (20130101) C25D 9/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043342 | Hunt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Hunt (Alexandria, Virginia); Guillermo R. Villalobos (Springfield, Virginia); Benjamin Rock (Rockville, Maryland); Shyam S. Bayya (Ashburn, Virginia); Woohong Kim (Washington, District of Columbia); Ishwar D. Aggarwal (Waxhaw, North Carolina); Bryan Sadowski (Falls Church, Virginia); Jasbinder S. Sanghera (Ashburn, Virginia) |
| ABSTRACT | The present invention provides a method for making a high strength, small grain size ceramic having a transgranular fracture mode by rapid densification of a green body and subsequent cooling of the densified ceramic. The ceramic may include dislocations, defects, dopants, and/or secondary phases that are formed as a result of the process and resulting in stress fields capable of redirecting or arresting cracks within the material. This ceramic can maintain transparency from ultraviolet to mid-wave infrared. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/380797 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/50 (20130101) C04B 35/64 (20130101) C04B 35/443 (20130101) C04B 35/505 (20130101) Original (OR) Class C04B 35/638 (20130101) C04B 35/4682 (20130101) C04B 2235/77 (20130101) C04B 2235/604 (20130101) C04B 2235/608 (20130101) C04B 2235/667 (20130101) C04B 2235/786 (20130101) C04B 2235/3208 (20130101) C04B 2235/3215 (20130101) C04B 2235/3222 (20130101) C04B 2235/3224 (20130101) C04B 2235/3225 (20130101) C04B 2235/3236 (20130101) C04B 2235/5409 (20130101) C04B 2235/5445 (20130101) C04B 2235/6025 (20130101) C04B 2235/6027 (20130101) C04B 2235/6562 (20130101) C04B 2235/6567 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043520 | Cheung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Kevin Cheung (Mercer Island, Washington); Ami Yamamoto (Seattle, Washington); Brad Krajina (Shoreline, Washington); Yin Huang (Bothell, Washington) |
| ABSTRACT | Provided herein are methods to reduce tumor cell proliferation in a cancer patient by administering an antibody that binds angiopoietin-like 7, wherein administering the angiopoietin-like 7 antibody can reduce necrosis formation, metastasis formation, and circulating tumor cells. |
| FILED | Thursday, August 03, 2023 |
| APPL NO | 18/365110 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/22 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043601 | Iezzi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Erick B. Iezzi (Mars, Pennsylvania); Keith B. Sutyak (Richmond, Virginia); Grant C. Daniels (Burke, Virginia); Eugene Camerino (Powhatan, Virginia) |
| ABSTRACT | Disclosed herein is a method and thermoset made by: reacting a di- or tri-functional isocyanate with a silyl-containing compound to form a polyurethane having at least one unreacted isocyanate group, reacting the polyurethane with an aminoalkylalkoxysilane to form an alkoxysilane-terminated polyurethane, and moisture-curing the alkoxysilane-terminated polyurethane to form the thermoset. The silyl-containing compound has the formula: SiR1n[R3—(O—CO—X—R3)m—OH]4-n. Each X is —O— or —NR2—; each R1 is an alkyl group or an aryl group; each R2 is —H, an alkyl group, or an aryl group; each R3 is an alkylene group; n is 0, 1, or 2; and each m is a non-negative integer. The thermoset may be degraded by treatment with a solution of a fluoride salt in an organic solvent. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/354764 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/307 (20130101) C08G 18/3893 (20130101) Original (OR) Class C08G 2150/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/16 (20130101) C08K 5/19 (20130101) C08K 5/544 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 9/005 (20130101) C09D 183/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043798 | AMINI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trailhead Biosystems Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nooshin AMINI (Cleveland, Ohio) |
| ABSTRACT | Methods for generating pre-oligodendrocyte progenitor cells (pre-OPCs), oligodendrocyte progenitor cells (OPCs) and pre-myelinating oligodendrocytes (preOLs) from human pluripotent stem cells are provided using chemically-defined culture media that allow for generation of pre-OPCs in as little as three days, SOX10+OLIG2+NKX2-2+OPCs in as little as twelve days and CD9+A2B5+O4+CNPase+preOLs in as little as eighteen days. Two alternative culture protocols for generating OPCs are provided. Culture media, isolated cell populations and kits are also provided. |
| FILED | Thursday, June 08, 2023 |
| APPL NO | 18/207363 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 2501/33 (20130101) C12N 2501/60 (20130101) C12N 2501/105 (20130101) C12N 2501/115 (20130101) C12N 2501/135 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043872 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang WANG (Wellesley, Massachusetts); Mark S. KLEMPNER (Boston, Massachusetts); Monir EJEMEL (Medfield, Massachusetts); Qi LI (Westwood, Massachusetts); Zuoshang XU (Wellesley, Massachusetts) |
| ABSTRACT | The invention provides synthetic promoters and methods of using the same. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 18/281703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) C12N 2830/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043899 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SYNVITROBIO, INC. (San Leandro, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary Z. Sun (San Leandro, California); Abel C. Chiao (San Leandro, California); Dan E. Robertson (San Leandro, California); Louis E. Metzger (San Leandro, California); Richard Mansfield (San Leandro, California); Kelly S. Trego (San Leandro, California) |
| ABSTRACT | Provided herein, in one aspect, is a composition for in vitro transcription and translation, comprising: a treated cell lysate derived from one or more host cells such as bacteria, archaea, plant or animal; a plurality of supplements for gene transcription and translation; an energy recycling system for providing and recycling adenosine triphosphate (ATP); and one or more exogenous additives. Methods for making and using the same are also provided. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/320389 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 207/07006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043936 | HARICHARAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Svasti HARICHARAN (San Diego, California) |
| ABSTRACT | Described herein are methods of prognosing/diagnosing an estrogen receptor positive (ER+) breast cancer in an African American subject. Also described herein are methods of treating an estrogen receptor positive (ER+) breast cancer in an African American subject. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 18/251045 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044623 | McNicholas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William E. McNicholas (Ellettsville, Indiana); Joshua E. Gwaltney (Sandborn, Indiana); Eric Scheid (Bloomington, Indiana); Matt E Cummings (Bedford, Indiana); Andrew Richard Davis (Mesa, Arizona) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | William E. McNicholas (Ellettsville, Indiana); Joshua E. Gwaltney (Sandborn, Indiana); Eric Scheid (Bloomington, Indiana); Matt E Cummings (Bedford, Indiana); Andrew Richard Davis (Mesa, Arizona) |
| ABSTRACT | Provided is a frangible munitions device optimized for a dome and cylinder that yields fragments having shapes corresponding to a predetermined embossment pattern upon explosive rupture. The embossment pattern includes a first set of inner regular hexagonal embossments formed into the dome and cylinder that are aligned with the axis of the cylinder, and a second set of outer pre-deformed hexagonal shapes that distort to produce regular hexagonal shapes after drawing into the cylinder wall. The second set of shapes are separated by sharp transition regions. The shapes are embossed in a repeated pattern around the hollow cylinder and the dome top. The dome yields a plurality of fragments having shapes corresponding to the first set of inner regular hexagonal embossments upon explosive rupture, while the cylinder yields a plurality of fragments having shapes corresponding to the second set of outer pre-deformed hexagonal embossments upon explosive rupture. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/213476 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/22 (20130101) F42B 12/24 (20130101) Original (OR) Class F42B 27/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044648 | Josemans et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Garrett K. Josemans (Fredericksburg, Virginia); Benjamin A. Baldwin (King George, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Garrett K. Josemans (Fredericksburg, Virginia); Benjamin A. Baldwin (King George, Virginia) |
| ABSTRACT | A device is provided for rotation rate measurement. The device includes a laser, pre- and post-selection polarizers, a birefringent crystal, and a detector. The laser emits a photon beam. The crystal separates the beam into separate parallel beams by phase difference in response to the rotation rate as measured by the detector. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/721094 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/661 (20130101) Original (OR) Class G01C 19/5614 (20130101) G01C 19/5649 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044755 | Ouyang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Ouyang (Norman, Oklahoma); Jizhong ZHOU (Norman, Oklahoma); Aifen ZHOU (Norman, Oklahoma) |
| ABSTRACT | A method of extracting viable bacterial cells from a soil sample by mixing a dispersant-surfactant solution with a soil sample to form a soil slurry, adding the soil slurry to a centrifuge tube containing a density gradient medium, centrifuging the centrifuge tube to form a solvent layer above the density gradient medium, wherein the solvent layer comprises viable bacterial cells, extracting the solvent layer containing the viable bacterial cells, combining the extracted solvent layer with a PBS solution to form a PBS-cell mixture, filtering the PBS-cell mixture to form a cell filtrate, depositing the cell filtrate into a second centrifuge tube containing a quantity of the density gradient medium, centrifuging the second centrifuge tube to form a second solvent layer comprising the viable bacterial cells, and extracting the second solvent layer from the second centrifuge medium to form a second cell filtrate comprising the viable bacterial cells. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/166739 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/10 (20130101) G01N 1/34 (20130101) Original (OR) Class G01N 2001/1025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044873 | Birnbaum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael Birnbaum (Arlington, Massachusetts); Connor Dobson (Somerville, Massachusetts) |
| ABSTRACT | Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458628 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/4748 (20130101) C07K 14/5437 (20130101) C07K 14/70532 (20130101) C07K 14/70539 (20130101) C07K 16/2803 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/035 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15045 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044938 | GRINOLDS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael S. GRINOLDS (Cambridge, Massachusetts); Sungkun HONG (Cambridge, Massachusetts); Patrick MALETINSKY (Cambridge, Massachusetts); Amir YACOBY (Cambridge, Massachusetts) |
| ABSTRACT | A sensing probe may be formed of a diamond material comprising one or more spin defects that are configured to emit fluorescent light and are located no more than 50 nm from a sensing surface of the sensing probe. The sensing probe may include an optical outcoupling structure formed by the diamond material and configured to optically guide the fluorescent light toward an output end of the optical outcoupling structure. An optical detector may detect the fluorescent light that is emitted from the spin defects and that exits through the output end of the optical outcoupling structure after being optically guided therethrough. A mounting system may hold the sensing probe and control a distance between the sensing surface of the sensing probe and a surface of a sample while permitting relative motion between the sensing surface and the sample surface. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485478 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/645 (20130101) G01N 24/10 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/025 (20130101) G01Q 60/38 (20130101) G01Q 60/54 (20130101) G01Q 70/14 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/022 (20130101) G01R 33/032 (20130101) G01R 33/60 (20130101) G01R 33/1284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044963 | Keller, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nokomis, Inc. (Canonsburg, Pennsylvania) |
| ASSIGNEE(S) | Nokomis, Inc. (Canonsburg, Pennsylvania) |
| INVENTOR(S) | Walter J. Keller, III (Bridgeville, Pennsylvania); Andrew Richard Portune (Oakdale, Pennsylvania); Todd Eric Chornenky (Carmichaels, Pennsylvania); William Anthony Davis (Perrysburg, Ohio) |
| ABSTRACT | An apparatus for detecting a condition or authenticity of one or more electronic devices includes an enclosure having an antenna integrated therewithin, a fixture mounted within a hollow interior of the enclosure, the fixture being configured to receive the one or more electronic devices and connect one or more signals to each of the one or more electronic devices and a sensor and controller assembly connected to the antenna and configured to process a signature of an emission of a radiofrequency (RF) energy from of one or more electronic devices having the one or more signals connected thereto. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/236314 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/002 (20130101) Original (OR) Class Electric Digital Data Processing G06F 21/73 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 2924/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240045067 | Smith et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A Smith (Norfolk, Virginia); Alan J Davis (Wakefield, Rhode Island); C Michael Traweek (Saint Leonard, Maryland); Anthony Ruffa (Hope Valley, Rhode Island) |
| ABSTRACT | An apparatus for obtaining oceanographic information includes a controllable coherent light source providing light to an aquatic region. A telescope receives backscattered light that is filtered by an ambient light filter. A first interferometer receives filtered, backscattered light and provides a particulate backscatter output and a Brillouin backscatter output. A second interferometer accepts the Brillouin backscattered light and spatially disperses it according to frequency into a fringe pattern. An image sensor receives the fringe pattern. A processor joined to the image sensor utilizes image sensor output properties to determine oceanographic information concerning the aquatic region. |
| FILED | Friday, August 04, 2023 |
| APPL NO | 18/230347 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4816 (20130101) G01S 7/4876 (20130101) G01S 17/89 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240045829 | Pawlowski et al. |
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| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Robert Pawlowski (Beaverton, Oregon); Sriram Aananthakrishnan (Lubbock, Texas) |
| ABSTRACT | Techniques for multi-dimensional network sorted array merging. A first switch of a plurality of switches of an apparatus may receive a first element of a first array and a first element of a second array. The first switch may determine that the first element of the first array is less than the first element of the second array. The first switch may cause the first element of the first array to be stored as a first element of an output array. |
| FILED | Wednesday, April 05, 2023 |
| APPL NO | 18/131143 |
| CURRENT CPC | Electric Digital Data Processing G06F 15/17375 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240046612 | Panetta et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); Research Foundation of the City University of New York (New York, New York) |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts); Research Foundation of the City University of New York (New York, New York) |
| INVENTOR(S) | Karen A. Panetta (Rockport, Massachusetts); Sos S. Agaian (New York, New York); Aruna Ramesh (Lincoln, Massachusetts); Shishir Paramathma Rao (Burlington, Massachusetts); Shreyas Kamath Kalasa Mohandas (Burlington, Massachusetts); Srijith Rajeev (Burlington, Massachusetts); Rahul Rajendran (Belleville, Michigan) |
| ABSTRACT | A method comprising: obtaining a plurality of data sets, each of the plurality of data sets being generated, at least in part, by using by a different one of a plurality of sensors, each of a plurality of sensors including a wearable sensor that is worn by a user or a sensor that is positioned at a same location as the user; combining the plurality of data sets to produce a fused data set; processing the fused data set to identify at least one of a performance of the user in completing a task, a cognitive load of the user, and/or one or more objects that are positioned at the same location as the user; and outputting an indication of a state of the user based on an outcome of the processing. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 18/256983 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 2207/10048 (20130101) G06T 2207/30204 (20130101) Image or Video Recognition or Understanding G06V 10/764 (20220101) Original (OR) Class G06V 40/18 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047115 | Kazemi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Kazemi (Rochester, New York); Eby G. Friedman (Rochester, New York); Engin Ipek (Rochester, New York) |
| ABSTRACT | A method of controlling a trajectory of a perpendicular magnetization switching of a ferromagnetic layer using spin-orbit torques in the absence of any external magnetic field includes: injecting a charge current Je through a heavy-metal thin film disposed adjacent to a ferromagnetic layer to produce spin torques which drive a magnetization M out of an equilibrium state towards an in-plane of a nanomagnet; turning the charge current Je off after te seconds, where an effective field experienced by the magnetization of the ferromagnetic layer Heff is significantly dominated by and in-plane anisotropy Hkx, and where M passes a hard axis by precessing around the Heff; and passing the hard axis, where Heff is dominated by a perpendicular-to-the-plane anisotropy Hkz, and where M is pulled towards the new equilibrium state by precessing and damping around Heff, completing a magnetization switching. |
| FILED | Monday, March 20, 2023 |
| APPL NO | 18/123418 |
| CURRENT CPC | Static Stores G11C 11/18 (20130101) G11C 11/161 (20130101) G11C 11/1675 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/329 (20130101) H01F 10/3286 (20130101) Original (OR) Class Pulse Technique H03K 19/18 (20130101) Electric solid-state devices not otherwise provided for H10N 50/00 (20230201) H10N 50/85 (20230201) H10N 52/00 (20230201) H10N 52/80 (20230201) H10N 52/101 (20230201) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 148/109 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047144 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nutech Ventures (Lincoln, Nebraska); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinsong Huang (Chapel Hill, North Carolina); Shuang Yang (Lincoln, Nebraska) |
| ABSTRACT | Electronic devices comprising a first layer, said first layer comprising a perovskite material; and a coating layer disposed on a surface of said first layer; wherein said coating layer comprises a coating oxysalt. Also provided herein are perovskite materials comprising: a coating layer on at least a portion of a surface of said perovskite material; wherein said coating layer comprises a coating oxysalt. Further provided herein are methods for forming a coating layer on a surface of a perovskite material comprising steps of: exposing said surface to a fluid having a precursor oxysalt dissolved therein such that said coating layer forms on said surface via a chemical reaction between said perovskite material and said precursor oxysalt; wherein said coating layer comprises a coating oxysalt. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485556 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/24 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2027 (20130101) Original (OR) Class H01G 9/2059 (20130101) Organic electric solid-state devices H10K 30/15 (20230201) H10K 85/30 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047592 | Jariwala et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deep Jariwala (Philadelphia, Pennsylvania); Jason Lynch (Philadelphia, Pennsylvania); Pawan Kumar (Philadelphia, Pennsylvania); Francisco Barrera (Miami, Florida); Artur Davoyan (Oakland, California) |
| ABSTRACT | Two-dimensional (2D) crystals have renewed opportunities in artificial lattice design and assembly without the constraints of epitaxy. However, the lack of thickness control in exfoliated van der Waals (vdW) layers prevents realization of repeat units with high fidelity. Uniform, wafer-scale samples permits engineering of both electronic and optical dispersions in stacks of disparate 2D layers with multiple repeating units. Systems, methods, and devices present optical dispersion engineering in a superlattice structure including alternating layers of 2D excitonic chalcogenides and dielectric insulators. Examples demonstrate >90% narrowband absorption in <4 nm active layer excitonic absorber medium at room temperature, concurrently with enhanced photoluminescence in cm2 samples. These superlattices show evidence of strong light-matter coupling and exciton-polariton formation with geometry-tunable coupling constants. The results demonstrate proof of concept structures with engineered optical properties and pave the way for a broad class of scalable, designer optical metamaterials from atomically-thin layers. |
| FILED | Thursday, March 09, 2023 |
| APPL NO | 18/181302 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/06 (20130101) C01G 41/00 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/04 (20130101) C01P 2006/40 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0159 (20210101) G02F 1/01708 (20130101) G02F 2203/10 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/032 (20130101) H01L 31/076 (20130101) H01L 31/035236 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240048248 | Sheehan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Matthew M. Sheehan (Washington, District of Columbia) |
| ABSTRACT | Provided are apparatus and methods for transmission of a signal in a safe and secure fashion. Embodiments include apparatus and methods that surround a signal beam(s) of interest with outer beams/signals to protect the inner signal. The outer beams construct a conduit like tunnel through which the signal beam(s) travels inside of for transmission to a receiving device. These outer beams further offer safety and security to the signal beam(s) of interest by cutting the signal source if these outer beams are broken. The outer beams can also modify the atmosphere around the signal beam(s) to an ideal, predetermined atmosphere to maximize signal propagation and minimize signal noise and loss. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/216457 |
| CURRENT CPC | Transmission H04B 10/85 (20130101) Original (OR) Class H04B 10/112 (20130101) H04B 10/501 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240048372 | CAMBOU et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bertrand F. CAMBOU (Flagstaff, Arizona); Ines MONTANO (Flagstaff, Arizona); Ryan BEHUNIN (Flagstaff, Arizona); Vince RODRIGUEZ (Flagstaff, Arizona) |
| ABSTRACT | The performance of quantum key distribution by systems and methods that use wavelength division multiplexing and encode information using both wavelength and polarization of photons of two or more wavelengths. Multi-wavelength polarization state encoding schemes allow ternary-coded digits, quaternary-coded digits and higher-radix digits to be represented by single photons. Information expressed in a first radix can be encoded in a higher radix and combined with a string of key values to produce a datastream having all allowed digit values of that radix in a manner that allows eavesdropping to be detected without requiring the sender and receiver to exchange additional information after transmission of the information. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/104705 |
| CURRENT CPC | Transmission H04B 10/70 (20130101) H04B 10/07957 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0858 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240048411 | Arvinte et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Marius Arvinte (Austin, Texas); Jonathan I. Tamir (Austin, Texas) |
| ABSTRACT | A system for processing data, comprising a scoring system operating on a processor and configured to receive a channel sample and a noise sample and to generate a channel estimate and a sampling system operating on the processor and configured to receive a pilot channel sample and the channel estimate and to iteratively modify the channel estimate until a predetermined error rate is achieved. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363016 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0224 (20130101) Original (OR) Class H04L 25/0254 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240048463 | MERLIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Raytheon BBN Technologies Corp (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christophe Jean-Claude MERLIN (Wakefield, Massachusetts); Daniel J. ELLARD (Belmont, Massachusetts); Prithwish BASU (Westford, Massachusetts); Souradip ROY (North Chelmsford, Massachusetts) |
| ABSTRACT | According to at least one aspect of the present disclosure a method for classifying flows on a network is provided. The method comprises determining a signature of a service's flows, collecting flow data having one or more attributes, responsive to collecting flow data, associating one or more ranges of the flow data with a value, responsive to associating the one or more ranges of the flow data with a value, composing a tensor having a dimensionality of one or more, responsive to composing the tensor, decomposing the tensor into one or more clusters, and responsive to decomposing the tensor into one or more clusters and determining the signature, comparing the signature to the one or more clusters and classifying one or more of the one or more clusters based on the signature. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169605 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/16 (20130101) H04L 43/026 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240048494 | Basu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prithwish Basu (Westford, Massachusetts); Christophe Jean-Claude Merlin (Wakefield, Massachusetts); Daniel J. Ellard (Belmont, Massachusetts) |
| ABSTRACT | According to at least one aspect of the present disclosure a method for detecting tunneled or multiplexed flows is provided. The method comprises: receiving an input; responsive to receiving the input, extracting a set of attributes of the input flow; responsive to extracting the set of attributes, reducing the dimensionality of the set of attributes to produce a reduced attribute set; responsive to producing the reduced attribute set, producing an output based on the reduced attribute set and a model; responsive to producing the output, comparing the output to the input to determine an error or loss; and responsive to determining the error or loss, categorizing the input as a multiplexed flow based on a threshold error or loss value. |
| FILED | Wednesday, February 15, 2023 |
| APPL NO | 18/169626 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/16 (20130101) H04L 41/142 (20130101) H04L 47/2441 (20130101) Original (OR) Class H04L 47/2483 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240048823 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Spectral MD, Inc. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shuai Yu (Mansfield, Texas); Jason Dwight (Dallas, Texas); Hanh Le (Rockwall, Texas); Jeffrey E. Thatcher (Irving, Texas); Wensheng Fan (Plano, Texas) |
| ABSTRACT | The present technology comprises a single-aperture snapshot multi-spectral imaging device generally consisting of at least a color camera, a customized Octa-Band optical filter, a motorized zoom lens, and an 8-wavelength multi-color LED illumination system. The present technology also comprises a method about designing time sequences and combinations of LED illuminations, along with an unmixing algorithm for 8 MSI images generation. According to the present device and method, it is capable of fast multi-spectral image acquisition speed (<100 milliseconds), fast post-processing speed based on adopting a single aperture system without disparity correction calculation, adjustable FOVs, smaller form factors and lower costs, and high precision of spectral information. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470318 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/7264 (20130101) A61B 2576/00 (20130101) Pictorial Communication, e.g Television H04N 23/11 (20230101) Original (OR) Class H04N 23/55 (20230101) H04N 23/56 (20230101) H04N 23/84 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240049584 | Forrest |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | A method for fabricating an organic electronic device comprises providing a plurality of photoresist structures on a substrate, the substrate having a first electrode layer, the photoresist structures having a bottom surface attached to the substrate and a top surface opposite the bottom surface, the top surface having a dimension greater than a dimension of the bottom surface, positioning a mask over the structures, the mask having a plurality of openings, and depositing an emissive material over the substrate through at least one of the plurality of openings to form at least one emissive element. An organic electronic device and a method of fabricating an organic electronic component are also described. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491050 |
| CURRENT CPC | Organic electric solid-state devices H10K 59/122 (20230201) H10K 71/166 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240049599 | Howe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HOWE INDUSTRIES LLC (Scottsdale, Arizona) |
| ASSIGNEE(S) | HOWE INDUSTRIES LLC (Scottsdale, Arizona) |
| INVENTOR(S) | Troy Michael Howe (Tempe, Arizona); Steven Daniel Howe (Mesa, Arizona) |
| ABSTRACT | A thermoelectric converter including a thermoelectric generator and a radiation source. The thermoelectric generator includes a hot source, a cold source, n-type material, and p-type material. The radiation source emits ionizing radiation that increases electrical conductivity. Also detailed is a method of using radiation to reach high efficiency with a thermoelectric converter that includes providing a thermoelectric generator and a radiation source, with the thermoelectric generator including a hot source, a cold source, n-type material, and p-type material, and emitting ionizing radiation with the radiation source to increase the electrical conductivity which strips electrons in the n-type material, the p-type material, or both the n-type material and p-type material from their nuclei with the electrons then free to move within the material. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/483085 |
| CURRENT CPC | Electric solid-state devices not otherwise provided for H10N 10/13 (20230201) Original (OR) Class H10N 10/17 (20230201) H10N 10/855 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240041376 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Jia Liu (Cambridge, Massachusetts); Paul Claude Henri Le Floch (Cambridge, Massachusetts); Hao Sheng (Cambridge, Massachusetts) |
| ABSTRACT | Articles and devices comprising fluorinated elastomers, as well as methods of preparing fluorinated elastomers, are generally described. In some cases, such fluorinated elastomers can be used for sensing neural activity, e.g., by encapsulating electronic circuits, or other applications. Furthermore, according to certain embodiments, polymers can, surprisingly, be directly deposited onto layers comprising low molecular weight fluorinated elastomers, e.g., without swelling in the presence of certain solvents. Some embodiments are generally directed to devices and methods for treating fluorinated elastomers and subsequently depositing material onto the treated fluorinated elastomers. This may allow the fabrication and patterning of multilayered articles comprising fluorinated elastomers. |
| FILED | Thursday, August 24, 2023 |
| APPL NO | 18/455535 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/268 (20210101) Original (OR) Class A61B 5/294 (20210101) A61B 5/388 (20210101) A61B 2562/125 (20130101) A61B 2562/164 (20130101) Compositions of Macromolecular Compounds C08L 27/12 (20130101) C08L 2203/202 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 171/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041417 | Fang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruogu Fang (Gainesville, Florida); Garrett Carlton Fullerton (Gainesville, Florida); Simon Kato (Gainesville, Florida) |
| ABSTRACT | Various examples are provided related to predicting perfusion images from non-contrast scans. In one example, a method for predicting perfusion images includes generating perfusion maps of an organ of a subject from non-contrast computed tomography (NCCT) slices of the organ; processing the perfusion maps based upon weights determined by a Physicians-in-the-Loop (PILO) module; and generating synthetic computed tomography perfusion (CTP) maps from the processed perfusion maps, the synthetic CTP maps generated by deep learning-based multimodal image translation. In another example, a system includes at least one computing device that can generate prefusion maps of an organ from NCCT slices; process the perfusion maps based upon weights determined by a PILO module; and generate synthetic CTP maps from the processed perfusion maps using deep learning-based multimodal image translation. The CTP maps can be rendered for display to a user. |
| FILED | Monday, August 07, 2023 |
| APPL NO | 18/230835 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/461 (20130101) A61B 6/501 (20130101) A61B 6/507 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 11/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041546 | Mondry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Mondry (Edina, Minnesota); Shane Farritor (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Thomas Frederick (Lincoln, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485601 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/20 (20160201) A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2017/2906 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0084 (20130101) B25J 9/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041742 | Deming et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy J. Deming (Los Angeles, California); Michael Delong (Los Angeles, California) |
| ABSTRACT | Provided herein are synthetic copolypeptide hydrogel compositions for use as dermal fillers, and methods of treating dermatological conditions using the same. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 18/265368 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/042 (20130101) A61K 8/64 (20130101) Original (OR) Class A61K 2800/91 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041786 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW JERSEY INSTITUTE OF TECHNOLOGY (Newark, New Jersey) |
| ASSIGNEE(S) | NEW JERSEY INSTITUTE OF TECHNOLOGY (Newark, New Jersey) |
| INVENTOR(S) | Xiaoyang Xu (Livingston, New Jersey); Zhongyu Li (Harrison, New Jersey) |
| ABSTRACT | Ionizable cationic lipid compounds have an amine moiety from amino alcohols and a lipid moiety from a lipid synthesized via esterification. The ionizable cationic lipid compounds which comprise an amino alcohol mediated ionizable cationic lipid compound are useful for in vivo or in vitro delivery of one or more nucleic acid agents including DNA, siRNA, a microRNA, an mRNA, a RNAi, and a plasmid. |
| FILED | Tuesday, June 13, 2023 |
| APPL NO | 18/209195 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 9/5192 (20130101) A61K 45/06 (20130101) A61K 48/0091 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042044 | DA ROCHA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sandro DA ROCHA (RICHMOND, Virginia); Rodrigo S. HEYDER (RICHMOND, Virginia) |
| ABSTRACT | Polymeric drugs for disease therapy are provided. The repeat units of the polymers comprise at least one chemotherapeutic agent, e.g. a cancer drug. The linkages between repeat units are hydrolysable under physiological conditions, e.g. at targeted sites in vivo. Nanoparticles formed from the polymers are also provided. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/641994 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/554 (20170801) Original (OR) Class A61K 47/593 (20170801) A61K 47/6935 (20170801) A61K 47/6953 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042101 | DeForest et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Cole DeForest (Seattle, Washington); Ivan Batalov (Seattle, Washington); Kelly Rose Stevens (Seattle, Washington) |
| ABSTRACT | Materials, methods, and systems for biorthogonal ligation of hydrogel labels to crosslinked-natural polymer hydrogels are provided. A heterobifunctional linker includes a peptide-reactive activated functional group on the heterobifunctional linker, including an activated amine-reactive functional group, an activated thiol-reactive functional group and being reactive with a hydrogel comprising a crosslinked natural polymer. The heterobifunctional linker also includes a photocaged reactive group including a photocaged hydroxylamine, a photocaged alkoxyamine, a photocaged hydrazide, a photocaged amine, a photocaged tetrazine, or a photocaged alkyne-containing moiety. The peptide-reactive activated functional group does not include an azide. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 18/258735 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Original (OR) Class Heterocyclic Compounds C07D 207/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042103 | Gerecht et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sharon Gerecht (Baltimore, Maryland); Morgan B. Elliott (Baltimore, Maryland); Hai-Quan Mao (Baltimore, Maryland); Theresa Chen (Baltimore, Maryland); Khyati Prasad (Baltimore, Maryland) |
| ABSTRACT | Described are methods for embedding one or more therapeutic agents into vascular grafts and other scaffold-based devices, and methods of implanting vascular grafts comprising tubular scaffolds into subjects. The tubular scaffolds comprise hydrogel nanofibers that have internally aligned polymer chains and may contain one or more therapeutic agents. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 18/256677 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) Original (OR) Class A61L 27/225 (20130101) A61L 27/507 (20130101) A61L 33/0017 (20130101) A61L 33/0076 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 23/00 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042107 | Maitland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan J. Maitland (College Station, Texas); Adam M. Orendain (Tulsa, Oklahoma) |
| ABSTRACT | An embodiment includes an apparatus comprising: a shape memory polymer (SMP) foam having an outside surface; and a membrane that encapsulates at least 50% of the outside surface of the SMP foam; wherein (a) the SMP foam includes a thermoset SMP, and (b) the membrane includes a thermoplastic polymer. Other embodiments are addressed herein. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/486236 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/12113 (20130101) A61B 17/12118 (20130101) A61B 17/12181 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/07 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) Original (OR) Class A61L 31/18 (20130101) A61L 31/146 (20130101) A61L 31/148 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042415 | Hernandez-Maldonado et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Puerto Rico (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arturo J. Hernandez-Maldonado (Mayaguez, Puerto Rico); Alberto Tous-Granados (Barranquilla, Colombia) |
| ABSTRACT | A bi-metallic coordination polymer comprising a transition metal and an alkaline earth metal is provided. In one aspect, the present disclosure provides a coordination polymer comprising a plurality of two-dimensional sheets, wherein the two-dimensional sheets arranged in parallel and comprising a plurality of transition metal cations coordinated by carboxylate-bearing ligands; and a plurality of pillars, wherein each pillar connects two adjacent two-dimensional sheets, and wherein each pillar is comprised of an alkaline earth metal coordinated to at least one β-diketonate moiety. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/361319 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/204 (20130101) B01D 2257/504 (20130101) B01D 2259/40088 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/3085 (20130101) B01J 20/3425 (20130101) B01J 20/3491 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043112 | Borazjani |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Iman Borazjani (College Station, Texas) |
| ABSTRACT | A supersonic flow system in which a supersonic flow is encountered includes a surface configured to be exposed to a supersonic fluid flow, wherein the surface includes an upstream end and a downstream end opposite the upstream end, a wave generator coupled to the surface and including one or more actuators configured to selectably induce strain in the surface, and a wave controller in signal communication with the wave generator and configured to activate the one or more actuators to induce one or more travelling waves configured to travel along the surface between the upstream end and the downstream end of the surface. |
| FILED | Wednesday, April 19, 2023 |
| APPL NO | 18/136526 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 21/01 (20230101) B64C 23/04 (20130101) Original (OR) Class B64C 30/00 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/04 (20130101) Jet-propulsion Plants F02K 7/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043369 | Craig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen L. Craig (Durham, North Carolina); Jeremiah A. Johnson (Cambridge, Massachusetts); Shu Wang (Durham, North Carolina); Michael Rubinstein (Durham, North Carolina); Abraham Herzog-Arbeitman (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are cyclobutane-based crosslinking compounds that, when incorporated into acrylate-based polymeric materials, can produce toughened acrylate polymer networks. Also disclosed herein are polymers comprising the crosslinkers, methods of preparing toughened polymer networks using the crosslinkers, and methods of using the polymer networks. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/343417 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 69/753 (20130101) C07C 69/757 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 36/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043688 | SCHLENOFF et al. |
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| FUNDED BY |
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| APPLICANT(S) | Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph SCHLENOFF (Tallahassee, Florida); Sandrine LTEIF (Tallahassee, Florida) |
| ABSTRACT | Described herein stabilized polysiloxane particles and methods for making and using the same. In one aspect, the composite includes (a) a polysiloxane comprising one or more positively charged groups and a negatively charged polyelectrolyte polymer or (b) a polysiloxane comprising one or more negatively charged groups and a positively charged polyelectrolyte polymer. Additionally, components such as, for example, inorganic drying agent, a filler, a reinforcing agent, magnetic particles, a wet/dry indicator, a pharmaceutical agent, a catalyst, or any combination thereof. The composites are effective in encapsulating hydrophobic materials that can subsequently be dispersed in aqueous medium. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356657 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 83/04 (20130101) Original (OR) Class C08L 2203/02 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 183/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043779 | WOOD et al. |
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| FUNDED BY |
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| APPLICANT(S) | SOUTH DAKOTA BOARD OF REGENTS (Pierre, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SCOTT WOOD (Rapid City, South Dakota); RAM SARASWAT (Rapid City, South Dakota) |
| ABSTRACT | A platform for culturing modular, biomimetic compositions such as tissues, cartilage, bone, synovial membrane, is accomplished through the use of a 3D printed platform with cell well, well plate frame with culture and analysis modules, coverglass bottoms for imaging, and cross-talk flow to connect tissue modules for paracrine signaling. Human chondrocytes can be generated and kept in a cell back and expanded to zonal models, osteoarthritis progression models. The use of titanium oxide nanotubes and can produce bone marrow stem cells differentiated toward osteoblasts. The synovial membrane can be modeled by an electrospun mesh, macrophages with an inducible phenotype (quiescent vs. wound repair vs. inflammatory). |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/487600 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 23/22 (20130101) C12M 25/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043815 | Sherman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David H. Sherman (Ann Arbor, Michigan); Amy E. Fraley (Ann Arbor, Michigan); Ashootosh Tripathi (Ypsilanti, Michigan) |
| ABSTRACT | The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals. |
| FILED | Monday, May 15, 2023 |
| APPL NO | 18/317683 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4995 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/182 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043816 | CLARKE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INDUSTRIAL MICROBES, INC. (Alameda, California) |
| ASSIGNEE(S) | INDUSTRIAL MICROBES, INC. (Alameda, California) |
| INVENTOR(S) | Elizabeth Jane CLARKE (San Francisco, California); Baolong ZHU (San Diego, California); Derek Lorin GREENFIELD (Kensington, California); Stephanie Rhianon JONES (Berkeley, California); Noah Charles HELMAN (El Cerrito, California) |
| ABSTRACT | Methods and compositions for the oxidation of short alkanes by engineered microorganisms expressing enzymes are described, along with methods of use. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/217021 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/0073 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) C12P 7/06 (20130101) C12P 7/22 (20130101) Enzymes C12Y 114/13025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043823 | PTACIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Synthorx, Inc. (Cambridge, Massachusetts); The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | Synthorx, Inc. (Cambridge, Massachusetts); The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Jerod PTACIN (La Jolla, California); Carolina CAFFARO (La Jolla, California); Hans AERNI (La Jolla, California); Yorke ZHANG (La Jolla, California); Emil C. FISCHER (La Jolla, California); Aaron W. FELDMAN (La Jolla, California); Vivian T. DIEN (La Jolla, California); Floyd E. ROMESBERG (La Jolla, California) |
| ABSTRACT | Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/481086 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/90 (20130101) C12N 15/113 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043893 | Weitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Huidan Zhang (Cambridge, Massachusetts); John Heyman (Cambridge, Massachusetts); Allon Moshe Klein (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets or other compartments, for instance, arising from a cell. In one set of embodiments, particles may be prepared containing oligonucleotides that can be used to determine target nucleic acids, e.g., attached to the surface of the particles. The oligonucleotides may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together or removed from the droplets. Certain embodiments of the invention are generally directed to systems and methods for attaching additional or arbitrary sequences to the nucleic acids within microfluidic droplets or other compartments, e.g., recognition sequences that can be used to selectively determine or amplify a desired sequence suspected of being present within a droplet. Such systems may be useful, for example, for selective amplification in various applications, such as high-throughput sequencing applications. |
| FILED | Friday, July 14, 2023 |
| APPL NO | 18/353058 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1006 (20130101) C12N 15/1065 (20130101) C12N 15/1093 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044713 | CHANDA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (ORLANDO, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DEBASHIS CHANDA (ORLANDO, Florida); SAYAN CHANDRA (ORLANDO, Florida); TIANYI GUO (ORLANDO, Florida) |
| ABSTRACT | An IR sensor comprises a substrate, a rear reflector on the substrate, a supporting layer a PCM layer carried by the supporting layer, and first and second electrically conductive contacts carried by the substrate and coupled to opposing sides of the PCM layer. The IR sensor also includes a circuit coupled to the first and second electrically conductive contacts and configured to apply an electrical bias signal to the PCM layer to generate an electrical oscillation, and detect the frequency modulation (FM) of the oscillation signal based upon IR radiation received by the PCM layer. |
| FILED | Monday, June 05, 2023 |
| APPL NO | 18/329061 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/02 (20130101) Original (OR) Class G01J 5/22 (20130101) Electric solid-state devices not otherwise provided for H10N 70/026 (20230201) H10N 70/231 (20230201) H10N 70/823 (20230201) H10N 70/8833 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044843 | Abdolvand et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reza Abdolvand (Orlando, Florida); Hakhamanesh Mansoorzare (Orlando, Florida) |
| ABSTRACT | Interaction of acoustic waves in a piezoelectric-semiconductor resonant cavity with the charge carriers in the semiconductor layer can be directed toward amplification of the acoustic waves; such amplification scheme can be applied in building unilateral amplifiers, zero loss filters, oscillators, high detection range circuit-less wireless sensors, isolators, duplexers, circulators and other acoustic devices. An apparatus for acoustoelectric amplification is described. The apparatus includes a semiconductor layer and a thin piezoelectric layer bonded (or deposited) onto the semiconductor layer forming an acoustic cavity. Two or more tethers forming a current conduction path through the semiconductor layer and two or more access pads to silicon are positioned on two ends of the acoustic cavity and configured to inject a DC current in the semiconductor layer. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/490329 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/041 (20130101) Original (OR) Class Electric solid-state devices not otherwise provided for H10N 30/85 (20230201) H10N 30/87 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044867 | Khismatullin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Administrators of the Tulane Educational Fund. (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Damir Khismatullin (New Orleans, Louisiana); Daishen Luo (Metalrie, Louisiana) |
| ABSTRACT | The disclosed apparatus, systems and methods relate to ATPA technology that provides a method for the real-time assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device. The acoustic tweezing technology integrates photo-optical tests used in plasma coagulation assays with mechanical (viscoelastic) tests used in whole blood analysis. Its key disruptive features are the increased reliability and accuracy due to non-contact measurement, low sample volume requirement, relatively short procedure time (less than 10 minutes), and the ability to assess the level of Factor XIII function from measurements of the fibrin network formation time. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/474960 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/272 (20130101) G01N 33/86 (20130101) G01N 33/4905 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240045002 | Shalaev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Vladimir M. Shalaev (West Lafayette, Indiana); Pramey Upadhyaya (West Lafayette, Indiana); Abhishek Bharatbhai Solanki (West Lafayette, Indiana); Simeon I. Bogdanov (Champaign, Illinois); Yong P. Chen (West Lafayette, Indiana); Mohammad Mushfiqur Rahman (West Lafayette, Indiana); Avinash Rustagi (West Lafayette, Indiana) |
| ABSTRACT | A nanodevice provides for electric-field control of magnon-QSD interactions. The nanodevice includes a ferroelectric substrate, a ferromagnetic material disposed over the ferroelectric substrate, and a nanodiamond including an ensemble of nitrogen-vacancy (NV) spins, each NV magnetically interfacing with the ferromagnetic material. An electric field is measured by applying a voltage across the ferroelectric substrate and the ferromagnetic material, changing a magnon excitation spectrum of the ferromagnetic material with respect to an electron spin resonance frequency of the ensemble of NV spins, and measuring a relaxation rate of the ensemble of NV spins. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/380091 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/02 (20130101) Original (OR) Class Electric solid-state devices not otherwise provided for H10N 50/80 (20230201) H10N 50/85 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240046114 | Milenkovic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oligica Milenkovic (Urbana, Illinois); Nagendra Athreya (Urbana, Illinois); Apratim Khandelwal (Champaign, Illinois); Jean-Pierre Leburton (Urbana, Illinois); Xiuling Li (Champaign, Illinois); Charles Schroeder (Champaign, Illinois); SeyedKasra Tabatabaei (Urbana, Illinois); Bo Li (Champaign, Illinois) |
| ABSTRACT | The present disclosure provides systems and methods that can provide portable, real-time accessible DNA memories. An example DNA-based data storage system includes a loading region configured to receive a plurality of DNA-based data storage elements in a suspension fluid and a plurality of microtubes disposed in a capture/release region. The microtubes are configured to capture and release the DNA-based data storage elements. The DNA-based data storage system also includes a linearization region configured to linearize the DNA-based data storage elements and a readout region with a readout device configured to provide information indicative of the respective DNA-based data storage elements. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/355107 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2310/52 (20130101) C12N 2310/3181 (20130101) C12N 2795/00031 (20130101) C12N 2795/00042 (20130101) Computer Systems Based on Specific Computational Models G06N 3/123 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047206 | Gagnon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jarod C. Gagnon (Finksburg, Maryland); Michael J. Presley (Silver Spring, Maryland); Steven M. Storck (Catonsville, Maryland); Jeffrey P. Maranchi (Clarksburg, Maryland) |
| ABSTRACT | A method for printing a semiconductor material includes depositing a molten metal onto a substrate in an enclosed chamber to form a trace having a maximum height of 15 micrometers and/or a maximum width of 25 micrometers to 10 millimeters and/or a thin film having a maximum height of 15 micrometers. The method further includes reacting the molten metal with a gas phase species in the enclosed chamber to form the semiconductor material. The depositing the molten metal includes depositing a metal composition including the molten metal and an etchant or depositing the etchant separate from the molten metal in the enclosed chamber. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/368662 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/406 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0262 (20130101) H01L 21/02554 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047895 | Yoon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Kyu Yoon (Gainesville, Florida); Payman Pahlavan (Gainesville, Florida); Suk-il Choi (Gainesville, Florida) |
| ABSTRACT | The present disclosure describes various systems and apparatuses for a compact frequency reconfigurable array antenna and methods related thereto. An exemplary array antenna system comprises a substrate; an array of patch antennas positioned on the substrate; a plurality of PIN diodes placed on a top surface of the substrate, wherein individual PIN diodes are located in individual gaps between respective ones of the patch antennas; and a plurality of meander-line (ML) complementary split-ring resonator (CSRR) decouplers placed on a bottom surface of the substrate, wherein individual ML-CSRR decouplers are placed under individual patch antennas in a diagonal direction. |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/351303 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 5/385 (20150115) H01Q 9/0442 (20130101) H01Q 21/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240048088 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University Of North Carolina At Charlotte (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyoung Hee Kim (Charlotte, North Carolina); Seyedehhamideh Hosseiniirani (Charlotte, North Carolina) |
| ABSTRACT | A photovoltaic curtain wall system includes a three-dimensional (3D) solar module configured to receive sunlight and reflect sun path geometry; an interior glass unit comprising a single or a double glass panel; an exterior glass panel offset from the interior glass unit forming a gap therebetween, wherein the gap is a conditioned, closed air cavity receiving the solar module. The solar module includes rotatable or fixed micro-oculus shaders at varying angles or curvatures, each micro-oculus shader including an ocular shape with an upper shading portion including photovoltaic elements and a lower shading portion, and the rotatable or fixed micro-oculus shaders are arranged in an array forming open areas therein that are configured to allow a view therethrough. The photovoltaic curtain wall system is a prefabricated curtain wall system configured to be integrated with a building. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/382147 |
| CURRENT CPC | General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 2/96 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/26 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240049588 | Azoulay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jason D. Azoulay (Atlanta, Georgia); Jasmine Lim (Rosemead, California); Naresh Eedugurala (Hattiesburg, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason D. Azoulay (Atlanta, Georgia); Jasmine Lim (Rosemead, California); Naresh Eedugurala (Hattiesburg, Mississippi) |
| ABSTRACT | The present invention relates to a photodetector and methods for making a photodetector configured for converting light to an electronic signal. The photodetector includes a substrate containing a hole transport component and electron transport component; one or more photoactive layers including one or more semiconducting materials that comprise a photoactive small molecule, oligomeric, or polymeric electron donor and an electron acceptor, wherein the electron donor has a narrow bandgap of less than 1.4 eV; and one or more insulating materials, wherein the one or more semiconducting materials and the one or more insulating materials are present in a weight ratio of 1:0.1 to about 1:100; a cathode in electrical contact with the electron or hole transport component; and an anode in electrical contact with the hole or electron transport component. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363319 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) C08G 2261/18 (20130101) C08G 2261/94 (20130101) C08G 2261/124 (20130101) C08G 2261/148 (20130101) C08G 2261/228 (20130101) C08G 2261/1412 (20130101) C08G 2261/3223 (20130101) C08G 2261/3243 (20130101) Organic electric solid-state devices H10K 30/30 (20230201) H10K 85/113 (20230201) Original (OR) Class H10K 85/151 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240042387 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SiTration, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | SiTration, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Brendan D. Smith (Cambridge, Massachusetts); Jatin Patil (Cambridge, Massachusetts); Daniel Bregante (Cambridge, Massachusetts); Ahmed Helal (Cambridge, Massachusetts); Hee Yun Choi Kim (Cambridge, Massachusetts); Morgan Baima (Cambridge, Massachusetts); Jeffrey C. Grossman (Cambridge, Massachusetts); Noah Letwat (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to systems and methods for electrically conductive membrane separation from a mixture solution via membrane nanofiltration, electro-filtration, or electro-extraction by: generating an electric field at the membrane filter, holding the membrane filter at a constant electric potential, or driving a constant current through the membrane filter; feeding a mixture solution through the membrane nanofiltration system; and separating a component from the mixture solution into a permeate solution. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/382884 |
| CURRENT CPC | Separation B01D 61/08 (20130101) Original (OR) Class B01D 61/027 (20130101) B01D 67/0062 (20130101) B01D 67/0072 (20130101) B01D 69/02 (20130101) B01D 71/0213 (20220801) B01D 2313/365 (20130101) B01D 2323/28 (20130101) B01D 2325/26 (20130101) B01D 2325/02833 (20220801) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/24 (20130101) C23C 16/50 (20130101) C23C 16/56 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/30 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240042438 | Holman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hoi-Ying N. Holman (Oakland, California); Wujun Zhao (Waunakee, Wisconsin); Sankar Raju Narayanasamy (Oakland, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to infrared spectroscopy. In one aspect, a device includes a first assembly, a porous membrane, and a second assembly. The first assembly defines a fluid distributor. The porous membrane overlies the fluid distributor and forms a surface of the fluid distributor. The second assembly is disposed on the first assembly. The second assembly defines a plurality of capillary arrays surrounding a window in the second assembly that exposes the porous membrane. Capillaries of each of the capillary arrays have openings on edges of the window of the second assembly and are operable to direct moisture across a surface of the porous membrane. |
| FILED | Wednesday, October 18, 2023 |
| APPL NO | 18/489182 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2200/027 (20130101) B01L 2300/12 (20130101) B01L 2300/0681 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2021/3595 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043356 | OHLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AMYRIS, INC. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas OHLER (Emeryville, California); Karl FISHER (Emeryville, California); Jin Ki HONG (Emeryville, California) |
| ABSTRACT | Provided herein are olefinic feedstocks derived from conjugated hydrocarbon terpenes (e.g., C10-C30 terpenes), methods for making the same, and methods for their use. |
| FILED | Thursday, September 21, 2023 |
| APPL NO | 18/371412 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 5/03 (20130101) C07C 5/05 (20130101) Original (OR) Class C07C 2521/04 (20130101) C07C 2523/44 (20130101) C07C 2523/75 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/04 (20130101) Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 105/02 (20130101) C10M 105/04 (20130101) C10M 107/14 (20130101) C10M 2203/003 (20130101) C10M 2203/022 (20130101) C10M 2203/024 (20130101) C10M 2203/0206 (20130101) C10M 2205/083 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/582 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043725 | Kryger |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | 3M INNOVATIVE PROPERTIES COMPANY (St. Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew J. Kryger (Hudson, Wisconsin) |
| ABSTRACT | Articles that include at least two substrates; and an adhesion promoter, wherein the adhesion promoter is a compound of formula I, (I) wherein x is an integer from 1 to 4, y is an integer from 2 to 6, and z is an integer from 1 to 6; and a structural adhesive positioned at least between the two substrates. Structural adhesives including such adhesion promoters and methods for bonding two substrates are also disclosed herein. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 18/257676 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 11/06 (20130101) C09J 163/00 (20130101) Original (OR) Class C09J 2301/50 (20200801) C09J 2301/408 (20200801) C09J 2400/163 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043786 | LAMMERS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter LAMMERS (Tempe, Arizona); Mark SEGER (Gilbert, Arizona); Wonkun PARK (Chandler, Arizona); Nicholas CSAKAN (Mesa, Arizona) |
| ABSTRACT | The present disclosure relates to methods of culturing algae that overcomes catabolic repression of photosynthesis in mixotrophic growth. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/484359 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 33/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043967 | Detrois et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Detrois (Salem, Oregon); Paul D. Jablonski (Salem, Oregon); Jeffrey A. Hawk (Salem, Oregon) |
| ABSTRACT | Nickel alloys, methods of making nickel alloys, articles including the nickel alloys, uses of the alloys, and methods of treating nickel alloys are described. The inventive heat resistant structural materials are suitable for applications requiring high yield stress at room temperature 5 and good creep strength at high temperatures, such as in gas turbines, steam turbines, fossil energy boilers, aero engines, power generation systems using fluids such as supercritical carbon dioxide (e.g., advanced ultra-supercritical power plants), concentrated solar power plants, nuclear power plants, molten salt reactors: turbine blades, casings, valves, heat exchangers and recuperators. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/490286 |
| CURRENT CPC | Alloys C22C 19/055 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043996 | Weimer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan W. Weimer (Niwot, Colorado); Amanda Hoskins (Superior, Colorado); Charles Musgrave (Longmont, Colorado) |
| ABSTRACT | The present invention relates, in part, to a discovery of a method for using atomic layer deposition (ALD) to improve the stability of refractory materials in high temperature steam, and compositions produced by the method. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/367022 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/00 (20130101) B81B 3/0075 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 28/06 (20130101) C04B 2111/00551 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/401 (20130101) C23C 16/402 (20130101) C23C 16/403 (20130101) C23C 16/4417 (20130101) C23C 16/45531 (20130101) Original (OR) Class C23C 16/45555 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044296 | Singh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Caterpillar Inc. (Peoria, Illinois) |
| ASSIGNEE(S) | Caterpillar Inc. (Peoria, Illinois) |
| INVENTOR(S) | Jaswinder Singh (Dunlap, Illinois); Eric Lee Schroeder (Germantown Hills, Illinois); Adam Joseph Clute (Lafayette, Indiana); Aaron Scott Ness (Battle Ground, Indiana) |
| ABSTRACT | Operating a gaseous fuel engine system includes controlling at least one of a delivery location, a delivery timing, or in situ mixing of a gaseous fuel with air, based on at least one engine system parameter upon the basis of which a blowby amount of a gaseous fuel to a crankcase varies. Crankcase accumulation of the gaseous fuel is maintained below a flammability limit. Related apparatus and control logic is also disclosed. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/879978 |
| CURRENT CPC | Controlling Combustion Engines F02D 19/021 (20130101) Original (OR) Class F02D 41/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044587 | Turney |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph E. Turney (Amston, Connecticut) |
| ABSTRACT | A heat exchanger includes a plurality of longitudinally-extending first channels and a plurality of second channels fluidly isolated from the plurality of first channels. Each first channel includes a plurality of internal fins and a plurality of external fins. The internal fins extend from and are integrally formed with the internal walls of the first channel. The external fins connect adjacent first channels. The plurality of second channels is defined by external walls of the plurality of first channels and the plurality of external fins. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881726 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 1/42 (20130101) Original (OR) Class F28F 2001/428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044588 | Turney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph E. Turney (Amston, Connecticut); Kathryn L. Kirsch (Manchester, Connecticut); Robert H. Dold (Monson, Massachusetts); Matthew B. Kennedy (Vernon, Connecticut) |
| ABSTRACT | A heat exchanger includes a plurality of longitudinally-extending first channels and a plurality of second channels fluidly isolated from the plurality of first channels. Each first channels includes a plurality of spiraling internal fins and a plurality of external fins. The internal fins extend from and are integrally formed with the internal walls of the first channel. The external fins connect extend from and are integrally formed with the external walls of the first channels, connecting channels together. The plurality of second channels is defined in part by external walls of the plurality of first channels and the plurality of external fins. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881731 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 1/42 (20130101) Original (OR) Class F28F 2001/428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044736 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Yung Y. Liu (Hinsdale, Illinois); Brian Craig (Downers Grove, Illinois); Zenghu Han (Woodridge, Illinois); Hirofumi Takeda (Chiba, Japan) |
| ABSTRACT | A system for monitoring stored spent fuel rods is provided, the system comprising: canisters containing the spent fuel rods; and temperature measuring means positioned on external surfaces of the canisters. Also provided is a method for monitoring stored spent fuel rods contained in canisters, the method comprising measuring temperature of the canisters at a plurality of external surfaces of each of the canisters, recording time of temperature differences between said external surfaces, determining time of oxidation initiation of the spent fuel rods based on the recording time, and preventing oxidation from occurring. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879722 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044780 | Liang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu-Lun Liang (Redwood City, California); William C. Chueh (Menlo Park, California) |
| ABSTRACT | Electrochemical reactivity is driven by the composition and structure of electrode surfaces. Monitoring surface chemistry in operando is thus crucial to understanding the behavior of electrodes yet is often inaccessible either due to resource limitations or to technical challenges in replicating realistic reaction environments. The invention presents a color impedance spectroscopy (CIS)-based technique to access operando surface measurements for mixed ionic-electronic conductors (MIECs). The CIS technique tunes the depth of charge carriers' movement within an electrode material by modulating the frequency of an applied AC electrochemical signal and monitors these changes spectroscopically. The results enable surface sensitivity in conventional bulk spectroscopies and provide new opportunities to characterize the operational behavior of MIEC electrodes. |
| FILED | Monday, July 17, 2023 |
| APPL NO | 18/222561 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) Original (OR) Class G01N 27/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044840 | Ewing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Robert G. Ewing (Kennewick, Washington); Elizabeth Denis (Seattle, Washington); Megan Nims (Richland, Washington); Garret L. Hart (West Richland, Washington) |
| ABSTRACT | Apparatus include a plurality of electrodes arranged in a sequence along a propagation axis between an ion inlet and an ion outlet to define an ion path and volume, wherein the electrodes are configured to receive respective voltages to produce an electric field in the volume that urges ions to propagate along the ion path downstream towards the ion outlet, wherein the sequence includes at least a first sequence portion including first and last electrodes configured to receive voltages according to a first function, and including at least one intermediate electrode situated between the first and last electrodes wherein the at least one intermediate electrode is configured to receive a voltage defining a voltage dip relative to the first function. Atmospheric flow tubes include a tube body and a central electrode configured to receive a time varying voltage configured to reduce a loss of the ions as the gas and ions flow along the flow tube volume to the flow tube outlet. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880232 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/622 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044883 | Morrison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Samuel S. Morrison (Richland, Washington); Lance R. Hubbard (Richland, Washington); Caleb J. Allen (Richland, Washington); Amy C. Sims (Richland, Washington); Matthew J. O'Hara (Richland, Washington); Nicolas E. Uhnak (Richland, Washington) |
| ABSTRACT | Methods for the near real-time detection of airborne analytes using imprinted micelles and electrochemical cells are described. The methods demonstrate selectivity to the imprinted micelles over others that are of similar size and configuration and are compatible with airborne aerosol sampling techniques. The detection method can be used to monitor and detect any airborne analyte, including pathogens (such as SARS-CoV-2), toxins, proteins, organic molecules, inorganic particles, chemicals, explosive particles, and environmental pollutants. |
| FILED | Wednesday, July 26, 2023 |
| APPL NO | 18/359300 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/283 (20130101) G01N 27/413 (20130101) G01N 33/54313 (20130101) Original (OR) Class G01N 33/56983 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240045002 | Shalaev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Vladimir M. Shalaev (West Lafayette, Indiana); Pramey Upadhyaya (West Lafayette, Indiana); Abhishek Bharatbhai Solanki (West Lafayette, Indiana); Simeon I. Bogdanov (Champaign, Illinois); Yong P. Chen (West Lafayette, Indiana); Mohammad Mushfiqur Rahman (West Lafayette, Indiana); Avinash Rustagi (West Lafayette, Indiana) |
| ABSTRACT | A nanodevice provides for electric-field control of magnon-QSD interactions. The nanodevice includes a ferroelectric substrate, a ferromagnetic material disposed over the ferroelectric substrate, and a nanodiamond including an ensemble of nitrogen-vacancy (NV) spins, each NV magnetically interfacing with the ferromagnetic material. An electric field is measured by applying a voltage across the ferroelectric substrate and the ferromagnetic material, changing a magnon excitation spectrum of the ferromagnetic material with respect to an electron spin resonance frequency of the ensemble of NV spins, and measuring a relaxation rate of the ensemble of NV spins. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/380091 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/02 (20130101) Original (OR) Class Electric solid-state devices not otherwise provided for H10N 50/80 (20230201) H10N 50/85 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240045144 | Namazi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Qunnect, Inc. (Brooklyn, New York) |
| ASSIGNEE(S) | Qunnect, Inc. (Brooklyn, New York) |
| INVENTOR(S) | Mehdi Namazi (Brooklyn, New York); Mael Flament (Brooklyn, New York); Yang Wang (New York, New York); Alexander Craddock (Brooklyn, New York) |
| ABSTRACT | A quantum memory device and methods for storage and retrieval of a qubit from the quantum memory device are described. The quantum memory device includes a first optical component to convert an input qubit encoded in an arbitrary polarization state of a photon into a spatial qubit propagating in a pair of parallel optical rails, an atomic vapor memory to store the spatial qubit in an atomic vapor, and a second optical component to combine the spatial qubit, when retrieved from the atomic vapor memory, into an output qubit encoded in an arbitrary polarization state of a photon. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 18/275567 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/2931 (20130101) G02B 6/29358 (20130101) Original (OR) Class G02B 27/283 (20130101) G02B 27/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240045718 | Dutu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | Alexandru Dutu (Bellevue, Washington); Marcus Nathaniel Chow (San Diego, California); Matthew D. Sinclair (Middleton, Wisconsin); Bradford M. Beckmann (Bellevue, Washington); David A. Wood (Madison, Wisconsin) |
| ABSTRACT | Techniques for executing workgroups are provided. The techniques include executing, for a first workgroup of a first kernel dispatch, a workgroup dependency instruction that includes an indication to prioritize execution of a second workgroup of a second kernel dispatch, and in response to the workgroup dependency instruction, dispatching the second workgroup of the second kernel dispatch prior to dispatching a third workgroup of the second kernel dispatch, wherein no workgroup dependency instruction including an indication to prioritize execution of the third workgroup has been executed. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488794 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/545 (20130101) G06F 9/3838 (20130101) G06F 9/4881 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240046007 | Tikadar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amitav Tikadar (Atlanta, Georgia); Yogendra K. Joshi (Atlanta, Georgia); Satish Kumar (Atlanta, Georgia) |
| ABSTRACT | In a method of generating a design of a cooling system for an electric motor according to a cooling system specification, a design for an evaporative cooling jacket for the electric motor is generated. The design is modelled by executing the following steps employing a computer program stored on a digital computer including a non-transitory computer readable storage medium. An electromagnetic model of the design for simulating electromagnetic parameters in the electric motor and the cooling system is generated. A motor heat transfer model of the design for determining heat transfer in the electric motor is generated. An evaporative heat transfer model for simulating heat transfer in the cooling system due to evaporative cooling is generated. A contact resistance model of the design to determine contact resistance between a rotor lamination-magnet, a winding-slot liner, a slot liner-stator lamination, and a stator lamination-housing is generated. A thermophysical properties model of the design that incorporates equivalent axial thermal conductivity (kz), density (ρ), and specific heat (Cp) of lamination material employed in the design is generated. Results of the electromagnetic model, the motor heat transfer model, the evaporative heat transfer model, the contact resistance model and the thermophysical properties model are compared to the cooling system specification. The design of the cooling system is modified when the results differ from the specification. |
| FILED | Wednesday, May 31, 2023 |
| APPL NO | 18/204294 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047007 | CHANG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hang CHANG (Moraga, California) |
| ABSTRACT | A method for determining a Lower Grade Glioma (LGG) subtype for a subject. A device for determining an LGG subtype in a subject. A system using machine learning for determining a Lower Grade Glioma (LGG) subtype in a subject. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363344 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) Original (OR) Class G16B 40/30 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047516 | Lordi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincenzo Lordi (Livermore, California); Noah Patrick Allen (Oakland, California); Qinghui Shao (Fremont, California); Clint Duncan Frye (Livermore, California); Kyoung Eun Kweon (Pleasanton, California); Lars F. Voss (Livermore, California); Joel Basile Varley (Livermore, California) |
| ABSTRACT | An apparatus, in accordance with one embodiment, includes a superjunction device having a voltage sustaining layer formed of a semiconductor material and a dopant in the voltage sustaining layer. The dopant is for distributing an electric field within the voltage sustaining layer. The dopant is more concentrated along a sidewall of the voltage sustaining layer than toward a center of the voltage sustaining layer, the sidewall extending at least a portion of the distance between a top surface and a bottom surface of a voltage sustaining layer. Methods of electric field-enhanced dopant diffusion to form a superjunction device are also presented. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880552 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/2258 (20130101) H01L 22/26 (20130101) H01L 29/207 (20130101) H01L 29/0634 (20130101) Original (OR) Class H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047531 | Cooper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | James Albert Cooper (Santa Fe, New Mexico); Dallas Todd Morisette (Lafayette, Indiana) |
| ABSTRACT | A metal oxide semiconductor (MOS)-based power device includes a semiconductor region, drain and source electrodes, a gate electrode separated from the semiconductor region by SiO2, where the channel length (CHL) has a range of between about 0.6 μm and about 0.5 μm, the silicon dioxide has a corresponding thickness (tox) range of between about 5 nm to about 30 nm, where the CHL has a range of between about 0.5 μm and about 0.4 μm, the tox has a corresponding range of between about 5 nm to about 25 nm, where the CHL has a range of between about 0.4 μm and about 0.3 μm, the tox has a corresponding range of between about 5 nm to about 20 nm, where the CHL has a range of between about 0.3 μm and about 0.2 μm, the tox has a corresponding range of between about 5 nm to about 15 nm. |
| FILED | Sunday, July 30, 2023 |
| APPL NO | 18/227969 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/74 (20130101) H01L 29/1045 (20130101) Original (OR) Class H01L 29/1608 (20130101) H01L 29/7397 (20130101) H01L 29/7802 (20130101) H01L 29/7813 (20130101) H01L 29/7816 (20130101) H01L 29/42364 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047595 | Sewell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Maxeon Solar Pte. Ltd. (Singapore, Singapore) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Hamilton Sewell (Los Altos, California); David Aaron Randolph Barkhouse (Oakland, California); Douglas Rose (Vista, California); Lewis Abra (San Francisco, California) |
| ABSTRACT | Wire-based metallization and stringing techniques for solar cells, and the resulting solar cells, modules, and equipment, are described. In an example, a substrate has a surface. A plurality of N-type and P-type semiconductor regions is disposed in or above the surface of the substrate. A conductive contact structure is disposed on the plurality of N-type and P-type semiconductor regions. The conductive contact structure includes a plurality of conductive wires, each conductive wire of the plurality of conductive wires essentially continuously bonded directly to a corresponding one of the N-type and P-type semiconductor regions. |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/380578 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0508 (20130101) Original (OR) Class H01L 31/0516 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047707 | Evans et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ESS TECH, INC. (Wilsonville, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig E. Evans (West Linn, Oregon); Sean Casey (Portland, Oregon); Yang Song (West Linn, Oregon) |
| ABSTRACT | A redox flow battery may include: a membrane interposed between a first electrode positioned at a first side of the membrane and a second electrode positioned at a second side of the membrane opposite to the first side; a first flow field plate comprising a plurality of positive flow field ribs, each of the plurality of positive flow field ribs contacting the first electrode at first supporting regions on the first side; and the second electrode, including an electrode spacer positioned between the membrane and a second flow field plate, the electrode spacer comprising a plurality of main ribs, each of the plurality of main ribs contacting the second flow field plate at second supporting regions on the second side, each of the second supporting regions aligned opposite to one of the plurality of first supporting regions. As such, a current density distribution at a plating surface may be reduced. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/486073 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8803 (20130101) H01M 4/8817 (20130101) H01M 4/8828 (20130101) H01M 8/20 (20130101) H01M 8/188 (20130101) H01M 8/0239 (20130101) H01M 8/0245 (20130101) H01M 8/0258 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047775 | LIPSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert L. LIPSON (Oak Park, Illinois); Jessica L. DURHAM (Braidwood, Illinois); Jeffrey S. SPANGENBERGER (Naperville, Illinois) |
| ABSTRACT | A method for recovering and recycling lithium battery components comprises shredding used batteries into fragments, recovering electrolyte from the fragments, aspirating the fragments to remove separator membrane fragments from other solid materials, magnetically separating the cathode fragments from the non-magnetic anode fragments on a rare earth roll separator; thermally removing binder and carbon from the cathode fragments, recovering delithiated cathode active material; relithiating the delithiated cathode active material, recovering aluminum foil from the cathode fragments; removing cathode active material from the anode fragments, and recovering copper foil from the anode fragments. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879468 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/215 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/40 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 1/02 (20130101) C22B 7/005 (20130101) C22B 15/0082 (20130101) C22B 21/0069 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 50/46 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047930 | Edwards et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Reid Edwards (Santa Monica, California); Pierre A. Michel (Oakland, California) |
| ABSTRACT | A diffractive optical element, such as a plasma grating, can be made by directing two laser beams so that they overlap in a nonlinear material to form an interference pattern in the nonlinear material. The interference pattern can modify the index of refraction in the nonlinear material to produce the diffractive optical element. This diffractive optical element may be used to separate the peak of a laser pulse from light preceding the peak thereby increase the temporal contrast of a laser pulse such as a compressed laser pulse. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/882421 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) Original (OR) Class H01S 3/08009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240049584 | Forrest |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | A method for fabricating an organic electronic device comprises providing a plurality of photoresist structures on a substrate, the substrate having a first electrode layer, the photoresist structures having a bottom surface attached to the substrate and a top surface opposite the bottom surface, the top surface having a dimension greater than a dimension of the bottom surface, positioning a mask over the structures, the mask having a plurality of openings, and depositing an emissive material over the substrate through at least one of the plurality of openings to form at least one emissive element. An organic electronic device and a method of fabricating an organic electronic component are also described. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491050 |
| CURRENT CPC | Organic electric solid-state devices H10K 59/122 (20230201) H10K 71/166 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240041546 | Mondry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Mondry (Edina, Minnesota); Shane Farritor (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Thomas Frederick (Lincoln, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485601 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/20 (20160201) A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2017/2906 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0084 (20130101) B25J 9/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044443 | Jones et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas C. Jones (Williamsburg, Virginia); William R. Doggett (Poquoson, Virginia); Iok M. Wong (Poquoson, Virginia) |
| ABSTRACT | A powered base assembly includes first and second structures that are operably interconnected by at least three legs that can include electrically-powered linear actuators. Each electrically powered actuator includes a housing and a rod associated with the housing. Each rod is connected to one of the first and second structures by a swivel joint having two degrees of freedom, and each housing is connected to the other of the first and second structure by a swivel joint having one degree of freedom. The linear actuators can be actuated to thereby change at least one of an angular position of the first structure relative to the second structure and a distance of the first structure, relative to the second structure. In this way, the base assembly may be used for leveling or moving a payload placed on the first structure; the payload weight is transferred linearly through the legs to the second structure. The configuration of the legs and the second structure enable to the second structure to be placed on a surface to support the base assembly while minimizing the bending moment on the second structure. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/880912 |
| CURRENT CPC | Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 11/22 (20130101) F16M 11/2021 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240045067 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A Smith (Norfolk, Virginia); Alan J Davis (Wakefield, Rhode Island); C Michael Traweek (Saint Leonard, Maryland); Anthony Ruffa (Hope Valley, Rhode Island) |
| ABSTRACT | An apparatus for obtaining oceanographic information includes a controllable coherent light source providing light to an aquatic region. A telescope receives backscattered light that is filtered by an ambient light filter. A first interferometer receives filtered, backscattered light and provides a particulate backscatter output and a Brillouin backscatter output. A second interferometer accepts the Brillouin backscattered light and spatially disperses it according to frequency into a fringe pattern. An image sensor receives the fringe pattern. A processor joined to the image sensor utilizes image sensor output properties to determine oceanographic information concerning the aquatic region. |
| FILED | Friday, August 04, 2023 |
| APPL NO | 18/230347 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4816 (20130101) G01S 7/4876 (20130101) G01S 17/89 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240046803 | KESHMIRI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shawn KESHMIRI (Lawrence, Kansas); Jeffrey XU (Lawrence, Kansas); Thomas LE PICHON (Kansas City, Kansas) |
| ABSTRACT | The present disclosure relates to systems, methods, and computer readable media implemented in connection with an unmanned aerial vehicle (UAV) to navigate a UAV along a desired path. For example, systems disclosed herein identify an anticipatory flight path and identify a plurality of reference points on the flight path relative to a current position of the UAV. The systems described herein may further determine reference angles between a current trajectory of the UAV and the reference points to determine an updated trajectory that the UAV should take to stay close to the identified flight path. The systems described herein may further cause the UAV to accelerate in a lateral direction based on the updated trajectory. The features and functionality of systems disclosed herein enable the UAV to accurately follow a complex path having sharp turns with little or no advanced knowledge of the flight path prior to departure. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/626050 |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 1/101 (20130101) Traffic Control Systems G08G 5/0021 (20130101) G08G 5/0039 (20130101) G08G 5/0069 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240047744 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuming WANG (Salt Lake City, Utah); Jan Dean MILLER (Salt Lake City, Utah); Patrick MULLER (Salt Lake City, Utah) |
| ABSTRACT | A composite solid electrolyte for lithium batteries can include a solid polymer, phyllosilicate nanoparticles distributed in the solid polymer, a lithium salt distributed in the solid polymer, and a plasticizer distributed in the solid polymer. The composite solid electrolyte can be used in a solid-state lithium battery cell made up of a composite solid electrolyte, an anode containing lithium in contact with a first surface of the composite solid electrolyte, and a cathode in contact with a second surface of the composite solid electrolyte. |
| FILED | Tuesday, May 23, 2023 |
| APPL NO | 18/322420 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0565 (20130101) Original (OR) Class H01M 10/0568 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240048431 | Barsoum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Constellation Designs, LLC (Wayne, Pennsylvania) |
| ASSIGNEE(S) | Constellation Designs, LLC (Wayne, Pennsylvania) |
| INVENTOR(S) | Maged F. Barsoum (San Jose, California); Christopher R. Jones (Pacific Palisades, California) |
| ABSTRACT | Communication systems are described that use signal constellations, which have unequally spaced (i.e. ‘geometrically’ shaped) points. In many embodiments, the communication systems use specific geometric constellations that are capacity optimized at a specific SNR. In addition, ranges within which the constellation points of a capacity optimized constellation can be perturbed and are still likely to achieve a given percentage of the optimal capacity increase compared to a constellation that maximizes dmin, are also described. Capacity measures that are used in the selection of the location of constellation points include, but are not limited to, parallel decode (PD) capacity and joint capacity. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488902 |
| CURRENT CPC | Transmission H04B 14/023 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) H04L 1/0009 (20130101) H04L 27/3405 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240049008 | Barsoum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Constellation Designs, LLC (Wayne, Pennsylvania) |
| ASSIGNEE(S) | Constellation Designs, LLC (Wayne, Pennsylvania) |
| INVENTOR(S) | Maged F. Barsoum (San Jose, California); Christopher R. Jones (Pacific Palisades, California) |
| ABSTRACT | Communication systems are described that use signal constellations, which have unequally spaced (i.e. ‘geometrically’ shaped) points. In many embodiments, the communication systems use specific geometric constellations that are capacity optimized at a specific SNR, over the Rayleigh fading channel. In addition, ranges within which the constellation points of a capacity optimized constellation can be perturbed and are still likely to achieve a given percentage of the optimal capacity increase compared to a constellation that maximizes dmin, are also described. Capacity measures that are used in the selection of the location of constellation points include, but are not limited to, parallel decode (PD) capacity and joint capacity. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488919 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) H04L 1/0009 (20130101) H04L 5/006 (20130101) H04L 27/3405 (20130101) Wireless Communication Networks H04W 24/02 (20130101) Original (OR) Class H04W 72/0453 (20130101) H04W 72/0473 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240049599 | Howe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HOWE INDUSTRIES LLC (Scottsdale, Arizona) |
| ASSIGNEE(S) | HOWE INDUSTRIES LLC (Scottsdale, Arizona) |
| INVENTOR(S) | Troy Michael Howe (Tempe, Arizona); Steven Daniel Howe (Mesa, Arizona) |
| ABSTRACT | A thermoelectric converter including a thermoelectric generator and a radiation source. The thermoelectric generator includes a hot source, a cold source, n-type material, and p-type material. The radiation source emits ionizing radiation that increases electrical conductivity. Also detailed is a method of using radiation to reach high efficiency with a thermoelectric converter that includes providing a thermoelectric generator and a radiation source, with the thermoelectric generator including a hot source, a cold source, n-type material, and p-type material, and emitting ionizing radiation with the radiation source to increase the electrical conductivity which strips electrons in the n-type material, the p-type material, or both the n-type material and p-type material from their nuclei with the electrons then free to move within the material. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/483085 |
| CURRENT CPC | Electric solid-state devices not otherwise provided for H10N 10/13 (20230201) Original (OR) Class H10N 10/17 (20230201) H10N 10/855 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240041024 | Cope et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| ASSIGNEE(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| INVENTOR(S) | Jason Cope (Ankeny, Iowa); George Singletary (Ankeny, Iowa); Todd Krone (Des Moines, Iowa); Sara Katherine Etter (Bondurant, Iowa) |
| ABSTRACT | Described are methods of field conditioning and preserving pollen and/or anthers from the Poaceae family of plants. A method of the present invention includes collecting fresh pollen and/or anthers and introducing the pollen and/or anthers to field conditioning conditions which regulate pollen moisture content. The field conditioning conditions may include an air flow at a humidity ranging from 50% to about 100% and a temperature ranging from about −10 to about 10° C. The field conditioning conditions and preservation conditions may further include a flow of one or more continuously refreshed, selected gases passing through pollen held on a permeable or impermeable surface. The field conditioning conditions may dehydrate the pollen to achieve a pollen moisture content of about 15% to about 35%. The preservation conditions may dehydrate the pollen to achieve a pollen moisture content of about 40% to about 58%. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/377964 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041040 | Werner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia); Arkion Life Sciences, LLC (New Castle, Delaware) |
| ASSIGNEE(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia); Arkion Life Sciences, LLC (New Castle, Delaware) |
| INVENTOR(S) | Scott J. Werner (Wellington, Colorado); Kenneth E Ballinger, JR. (East Wakefield, New Hampshire) |
| ABSTRACT | In certain aspects, the present disclosure relates to a composition comprising 30% to 45% vol/vol castor oil, 25% to 35% vol/vol propylene glycol, 5% to 15% vol/vol oleic acid, 15% to 25% wt/vol rodent repellent, and 0% to 10% vol/vol water. The disclosure also relates to methods of repelling a rodent from a substrate comprising applying to a substrate the compositions described herein. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/223659 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) A01N 43/40 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 17/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240041807 | Marini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan C. Marini (Houston, Texas); Sandesh Chakravarthy Sreenath Nagamani (Bellaire, Texas) |
| ABSTRACT | Embodiments of the disclosure include certain formulations for methods of treating urea cycle disorders. The methods encompass compositions that comprise benzoate and phenylbutyrate that may be at certain doses and have certain ratios of the components. The benzoate and phenylbutyrate may act synergistically in treatment of the urea cycle disorders, in particular embodiments. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/485093 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/216 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043631 | Minty et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ecovia Renewables Inc. (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy J. Minty (Ann Arbor, Michigan); Samuel Kohley (Ann Arbor, Michigan); Daniel Lee (Arlington, Virginia); Harry Poppick (Ann Arbor, Michigan) |
| ABSTRACT | Described are rheology modifier compositions comprising cross-linked poly(amino acid) and methods of their use in aqueous compositions. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335378 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/00 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/20 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 8/88 (20130101) A61K 8/0241 (20130101) A61K 47/42 (20130101) A61K 2800/10 (20130101) A61K 2800/48 (20130101) A61K 2800/546 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/00 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 16/04 (20130101) C04B 24/12 (20130101) C04B 24/2652 (20130101) C04B 2103/0079 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 3/124 (20130101) Original (OR) Class C08J 2377/04 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/43 (20180101) C09D 11/04 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/035 (20130101) C09K 8/70 (20130101) C09K 8/685 (20130101) Detergent Compositions; Use of Single Substances as Detergents; Soap or Soap-making; Resin Soaps; Recovery of Glycerol C11D 3/3719 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043864 | Brown et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Judith K. Brown (Tucson, Arizona); Mosharrof Hossain Mondal (Tucson, Arizona); Jorge Rafael Paredes Montero (Tucson, Arizona) |
| ABSTRACT | The present invention relates to compositions and methods for controlling psyllid infestation of plants. In particular, the present invention provides vectors comprising sequences designed to control psyllids by RNA interference (RNAi) and transgenic plants transformed with such vectors. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 18/269021 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/8286 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240041024 | Cope et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| ASSIGNEE(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| INVENTOR(S) | Jason Cope (Ankeny, Iowa); George Singletary (Ankeny, Iowa); Todd Krone (Des Moines, Iowa); Sara Katherine Etter (Bondurant, Iowa) |
| ABSTRACT | Described are methods of field conditioning and preserving pollen and/or anthers from the Poaceae family of plants. A method of the present invention includes collecting fresh pollen and/or anthers and introducing the pollen and/or anthers to field conditioning conditions which regulate pollen moisture content. The field conditioning conditions may include an air flow at a humidity ranging from 50% to about 100% and a temperature ranging from about −10 to about 10° C. The field conditioning conditions and preservation conditions may further include a flow of one or more continuously refreshed, selected gases passing through pollen held on a permeable or impermeable surface. The field conditioning conditions may dehydrate the pollen to achieve a pollen moisture content of about 15% to about 35%. The preservation conditions may dehydrate the pollen to achieve a pollen moisture content of about 40% to about 58%. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/377964 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043512 | Lu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ImCare Biotech, LLC (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanyong Lu (Horaham, Pennsylvania); Felix LU (Burbank, California) |
| ABSTRACT | Two classes of anti-AS-SPIK antibodies that specifically bind to one of two different conformational epitopes are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to diagnose and/or treat disorders characterized by the expression of AS-SPIK (e.g., liver cancer). Diagnostic methods and kits comprising the anti-AS-SPIK antibodies are also disclosed. |
| FILED | Tuesday, August 18, 2020 |
| APPL NO | 17/641780 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/31 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043816 | CLARKE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INDUSTRIAL MICROBES, INC. (Alameda, California) |
| ASSIGNEE(S) | INDUSTRIAL MICROBES, INC. (Alameda, California) |
| INVENTOR(S) | Elizabeth Jane CLARKE (San Francisco, California); Baolong ZHU (San Diego, California); Derek Lorin GREENFIELD (Kensington, California); Stephanie Rhianon JONES (Berkeley, California); Noah Charles HELMAN (El Cerrito, California) |
| ABSTRACT | Methods and compositions for the oxidation of short alkanes by engineered microorganisms expressing enzymes are described, along with methods of use. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/217021 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/0073 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) C12P 7/06 (20130101) C12P 7/22 (20130101) Enzymes C12Y 114/13025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240044963 | Keller, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nokomis, Inc. (Canonsburg, Pennsylvania) |
| ASSIGNEE(S) | Nokomis, Inc. (Canonsburg, Pennsylvania) |
| INVENTOR(S) | Walter J. Keller, III (Bridgeville, Pennsylvania); Andrew Richard Portune (Oakdale, Pennsylvania); Todd Eric Chornenky (Carmichaels, Pennsylvania); William Anthony Davis (Perrysburg, Ohio) |
| ABSTRACT | An apparatus for detecting a condition or authenticity of one or more electronic devices includes an enclosure having an antenna integrated therewithin, a fixture mounted within a hollow interior of the enclosure, the fixture being configured to receive the one or more electronic devices and connect one or more signals to each of the one or more electronic devices and a sensor and controller assembly connected to the antenna and configured to process a signature of an emission of a radiofrequency (RF) energy from of one or more electronic devices having the one or more signals connected thereto. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/236314 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/002 (20130101) Original (OR) Class Electric Digital Data Processing G06F 21/73 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 2924/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240044938 | GRINOLDS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael S. GRINOLDS (Cambridge, Massachusetts); Sungkun HONG (Cambridge, Massachusetts); Patrick MALETINSKY (Cambridge, Massachusetts); Amir YACOBY (Cambridge, Massachusetts) |
| ABSTRACT | A sensing probe may be formed of a diamond material comprising one or more spin defects that are configured to emit fluorescent light and are located no more than 50 nm from a sensing surface of the sensing probe. The sensing probe may include an optical outcoupling structure formed by the diamond material and configured to optically guide the fluorescent light toward an output end of the optical outcoupling structure. An optical detector may detect the fluorescent light that is emitted from the spin defects and that exits through the output end of the optical outcoupling structure after being optically guided therethrough. A mounting system may hold the sensing probe and control a distance between the sensing surface of the sensing probe and a surface of a sample while permitting relative motion between the sensing surface and the sample surface. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485478 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/645 (20130101) G01N 24/10 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/025 (20130101) G01Q 60/38 (20130101) G01Q 60/54 (20130101) G01Q 70/14 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/022 (20130101) G01R 33/032 (20130101) G01R 33/60 (20130101) G01R 33/1284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240045872 | Stephens et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Airmettle, Inc. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donpaul C. Stephens (Houston, Texas); Joshua R. Fuhs (Columbus, Indiana); Mohit Anand (Dallas, Texas) |
| ABSTRACT | A technique for managing multi-dimensional data includes providing an original dataset containing data arranged along multiple dimensions, each dimension covering a respective original range of dimensional units. The technique further includes extracting multiple portions of data from the original dataset, each portion extending over a reduced range of dimensional units, smaller than the original range, in at least one dimension, and all extracted portions together covering the original ranges of the original dataset in all dimensions. |
| FILED | Wednesday, August 02, 2023 |
| APPL NO | 18/364109 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/254 (20190101) G06F 16/2264 (20190101) G06F 16/24556 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240041881 | Habib |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amyn Aziz Habib (Washington, District of Columbia) |
| ABSTRACT | Provided herein are methods and pharmaceutical compositions for treating cancer, in a patient in need thereof, said method comprising administering to said patient an effective amount of an EGFR inhibitor and a TNF inhibitor. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/141965 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/573 (20130101) A61K 38/1793 (20130101) A61K 39/395 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240043931 | Rus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Horea G. Rus (Catonsville, Maryland); Freidrich ANSELMO (Germantown, Maryland); Alexandru TATOMIR (Baltimore, Maryland) |
| ABSTRACT | A MS disease activity (MSDA) score is provided as a tool to detect relapse and response to glatiramer acetate (GA) therapy in subjects having relapsing-remitting multiple sclerosis (RRMS) using the blood-based biomarkers SIRT1, RGC-32, FasL, IL-21, pSIRT1 and JNK p54. |
| FILED | Thursday, August 03, 2023 |
| APPL NO | 18/364581 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2800/52 (20130101) G01N 2800/60 (20130101) G01N 2800/285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240046198 | AMATO |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. AMATO (Ocean Isle Beach, North Carolina) |
| ABSTRACT | Systems and methods for enhancing digitally informed delivery of delivery items, such as mail or packages. A delivery item has an associated digital resource(s), such as electronic text, a digital file, an image, a web page(s), or the like. The delivery item includes an indicia, such as a bar code, that provides access to, or references, the digital resource. When the delivery item is processed during transit from the sender to the recipient of the delivery item, the indicia is scanned, read, or decoded, and the associated digital resource is identified therefrom. The delivery service transmits, to the recipient, an electronic notification indicating that the delivery item is enroute to the recipient and also indicating the associated digital resource. The recipient can then access the digital resource, e.g., the custom text, files, images or web pages associated with the delivery item. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/490388 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0838 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 1/00222 (20130101) H04N 1/32144 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240046398 | Punnoose et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Josen Punnoose (Crofton, Maryland); Sachin Agarwal (Washington, District of Columbia) |
| ABSTRACT | Generating authentication credentials includes receiving from a first user input identifying a customer identifier for an online account with a business or organization and a residential or business physical address, and sending via a network a notification to a first user system to follow instructions on a mail piece to be received by the first user. The mail piece is physically sent via a distribution network to the physical address and an online application is activated in response to scanning a coded indicia on the mail piece. Data indicative of an identity of the first user is received and the identity of the first user is verified based on at least information associated with the coded indicia and the received data. A recommendation is generated whether to approve the online account and an electronic credential is created for the first user based on acceptance of the online account. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/486928 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/31 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 30/413 (20220101) Wireless Communication Networks H04W 4/029 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240046801 | Fry |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark A. Fry (Marco Island, Florida) |
| ABSTRACT | Systems and methods of detecting a vortex made by a travelling object is disclosed. Techniques include positioning a media collector to capture a visual media file of the vortex. In some configurations, a graphic recognition algorithm and vortex similarity engine are used to determine whether a visual media file captured by a media collector contains a vortex. In some configurations, a computer may trigger an alert if a travelling object vortex is not expected to be in the visual media file. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/379235 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/74 (20220101) G06V 10/761 (20220101) G06V 10/7715 (20220101) Traffic Control Systems G08G 5/003 (20130101) Original (OR) Class G08G 5/0017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20240046612 | Panetta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); Research Foundation of the City University of New York (New York, New York) |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts); Research Foundation of the City University of New York (New York, New York) |
| INVENTOR(S) | Karen A. Panetta (Rockport, Massachusetts); Sos S. Agaian (New York, New York); Aruna Ramesh (Lincoln, Massachusetts); Shishir Paramathma Rao (Burlington, Massachusetts); Shreyas Kamath Kalasa Mohandas (Burlington, Massachusetts); Srijith Rajeev (Burlington, Massachusetts); Rahul Rajendran (Belleville, Michigan) |
| ABSTRACT | A method comprising: obtaining a plurality of data sets, each of the plurality of data sets being generated, at least in part, by using by a different one of a plurality of sensors, each of a plurality of sensors including a wearable sensor that is worn by a user or a sensor that is positioned at a same location as the user; combining the plurality of data sets to produce a fused data set; processing the fused data set to identify at least one of a performance of the user in completing a task, a cognitive load of the user, and/or one or more objects that are positioned at the same location as the user; and outputting an indication of a state of the user based on an outcome of the processing. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 18/256983 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 2207/10048 (20130101) G06T 2207/30204 (20130101) Image or Video Recognition or Understanding G06V 10/764 (20220101) Original (OR) Class G06V 40/18 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 20240047676 | Wagner |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Wagner (Rockville, Maryland) |
| ABSTRACT | Systems and methods are disclosed for a method of production of carbon nanochain, for use as cathodes, either alone or in combination with multi-walled carbon nanotubes. The carbon nanochain precursors are heated in the presence of inert atmosphere to synthesize the carbon nanochains. The carbon nanochains have high gravimetric and volumetric capacity and good cycle life when used as cathodes in Li—O2 batteries. The performance of Li—O2 battery cathodes comprised of mixtures of carbon nanochains and multiwalled carbon nanotubes is dramatically improved relative to cathodes comprised of either material in the absence of the other. |
| FILED | Friday, August 04, 2023 |
| APPL NO | 18/230547 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/583 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20240041786 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW JERSEY INSTITUTE OF TECHNOLOGY (Newark, New Jersey) |
| ASSIGNEE(S) | NEW JERSEY INSTITUTE OF TECHNOLOGY (Newark, New Jersey) |
| INVENTOR(S) | Xiaoyang Xu (Livingston, New Jersey); Zhongyu Li (Harrison, New Jersey) |
| ABSTRACT | Ionizable cationic lipid compounds have an amine moiety from amino alcohols and a lipid moiety from a lipid synthesized via esterification. The ionizable cationic lipid compounds which comprise an amino alcohol mediated ionizable cationic lipid compound are useful for in vivo or in vitro delivery of one or more nucleic acid agents including DNA, siRNA, a microRNA, an mRNA, a RNAi, and a plasmid. |
| FILED | Tuesday, June 13, 2023 |
| APPL NO | 18/209195 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 9/5192 (20130101) A61K 45/06 (20130101) A61K 48/0091 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20240044757 | SCAVO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Laura Elizabeth Schiffrin SCAVO (Bethesda, Maryland); Adam C. GOODWIN (Baltimore, Maryland) |
| ABSTRACT | An electrostatic probe for positioning an insect specimen is disclosed herein. The electrostatic probe may include an ion generator, a handling end, and a controller. The controller may be configured to: activate the ion generator to produce a electrostatic field at the handling end, wherein the electrostatic field is to attract a specimen to the handling end or hold the insect specimen at the handling end, and discharge the electrostatic field to cause the insect specimen to be released from the handling end. |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/753550 |
| CURRENT CPC | Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 1/026 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240044683 | KERTESZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE ADMINISTRATOR OF THE U.S. (Washington, District of Columbia); URBANALTA CORP (Cincinnati, Ohio) |
| ASSIGNEE(S) | GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE ADMINISTRATOR OF THE U.S. (Washington, District of Columbia); URBANALTA CORP (Cincinnati, Ohio) |
| INVENTOR(S) | Ruben KERTESZ (Cincinnati, Ohio); Daniel J. MURRAY, JR. (Cincinnati, Ohio); Michael BOLAN (Cincinnati, Ohio); Ryan ANDERSON (Cincinnati, Ohio); Chunsheng FANG (Redwood City, California) |
| ABSTRACT | A flow imaging and monitoring system for synchronized management of wide area drainage that includes an interposer for supporting monitoring and management equipment in a manhole, a module for illuminating water flowing in pipes at the base of the manhole, a module for monitoring responses to reflected light, a sealed and rechargeable battery pack, and a data analysis and management system to interpret data streams in real time. The interposer can be adjusted to fit the diameter of the manhole and can be adjusted to be placed under the manhole cover. The module for illuminating the flowing water can be adjusted to generate various frequencies. The support structures for the modules can be adjusted for varying pitch, roll and yaw with respect to the manhole. The data analysis and management system is supported by cloud computing. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/486007 |
| CURRENT CPC | Sewers; Cesspools E03F 7/00 (20130101) E03F 2201/20 (20130101) E03F 2201/40 (20130101) Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/02 (20130101) Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/002 (20130101) G01F 1/66 (20130101) G01F 1/661 (20130101) G01F 1/662 (20130101) Original (OR) Class G01F 1/666 (20130101) G01F 1/704 (20130101) G01F 1/7086 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/4257 (20130101) H01M 50/251 (20210101) H01M 2010/4271 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/8158 (20150401) Y10T 137/8359 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240045119 | Starkovich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northrop Grumman Systems Corporation (Falls Church, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Starkovich (Redondo Beach, California); Edward M. Silverman (Redondo Beach, California) |
| ABSTRACT | A method using capillary force lamination (CFL) for manufacturing a high-performance optical absorber, includes: texturizing a base layer of the high-performance optical absorber, the base layer comprising one or more of a polymer film and a polymer coating; joining a surface layer of the high-performance optical absorber to the base layer, the surface layer comprising a non-woven carbon nanotube (CNT) sheet; wetting the joined surface layer and base layer with a solvent; allowing surface tension forces of the solvent to draw the non-woven CNT sheet into the base layer, thereby texturizing the surface layer; drying the joined surface layer and base layer; and treating the resulting base layer with plasma, creating the high-performance optical absorber. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/379365 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/0074 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Optical Elements, Systems, or Apparatus G02B 5/003 (20130101) Original (OR) Class G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, February 08, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240208.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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