FedInvent™ Patent Applications
Application Details for Thursday, March 07, 2024
This page was updated on Tuesday, June 18, 2024 at 02:15 PM GMT
Department of Health and Human Services (HHS)
| US 20240074687 | Brunner et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Peter Brunner (St. Louis, Missouri); Hohyun Cho (St. Louis, Missouri) |
| ABSTRACT | Systems and methods for detecting oscillations in neural signals are disclosed that provide for high precision and specificity in detecting neural oscillations in time and frequency domains. The disclosed systems and methods identify oscillations according to criteria including 1/f noise, number of cycles, and auto-correlation. The disclosed method detects periodic signals and filters out spurious oscillations associated with harmonic frequencies. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/193930 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/242 (20210101) Original (OR) Class A61B 5/742 (20130101) A61B 5/7225 (20130101) A61B 5/7246 (20130101) A61B 5/7253 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240074699 | Morris et al. |
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| FUNDED BY |
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| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Christopher Morris (Franklin Lakes, New Jersey); Tara Lynn Alvarez (Whippany, New Jersey); Mitchell Scheiman (Bala Cynwyd, Pennsylvania); Chang Yaramothu (Hackensack, New Jersey); John Vito d'Antonio-Bertagnolli (Mount Laurel, New Jersey) |
| ABSTRACT | Disclosed is a system, method, and apparatus for quantification and feedback of eye deviations during normal viewing conditions. A sensory biofeedback system serves to emit a sensory cue such as a tone or vibration when a certain threshold of eye deviation has been exceeded. The biofeedback system allows objective monitoring of the accuracy of eye alignment that can be used outside of a clinical setting or inside a clinical setting. |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/243354 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/0041 (20130101) A61B 3/085 (20130101) A61B 3/113 (20130101) A61B 5/486 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/4076 (20130101) A61B 5/4836 (20130101) A61B 5/4863 (20130101) Original (OR) Class A61B 5/6803 (20130101) A61B 5/6814 (20130101) A61B 5/7271 (20130101) A61B 5/7405 (20130101) A61B 5/7455 (20130101) A61B 2505/07 (20130101) A61B 2560/0223 (20130101) A61B 2560/0406 (20130101) A61B 2560/0443 (20130101) A61B 2560/0462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240074734 | Urban et al. |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota); Akademia Gorniczo-Hutnicza Im. Stanislawa Staszica W Krakowie (Krakow, Poland) |
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| INVENTOR(S) | Matthew W. Urban (Rochester, Minnesota); Piotr Kijanka (Krakow, Poland) |
| ABSTRACT | Shear wave phase velocity is estimated from measurements of shear wave motion obtained using ultrasound shear wave elastography or other suitable elastography techniques. Shear wave dispersion curves are generated using a combined generalized Stockwell transform and slant wave number-frequency analysis. A modified version of the S-transform is used to control the time-frequency resolution of a time-frequency decomposition of a signal. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/262345 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/54 (20130101) A61B 8/485 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4814 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240074735 | JOKERST et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
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| INVENTOR(S) | Jesse JOKERST (La Jolla, California); Yash Mantri (La Jolla, California) |
| ABSTRACT | A method is provided for treating a skin wound. In accordance with the method, an ultrasound image is obtained of a skin wound on a patient. The ultrasound image is processed to extract information that is correlated to a degree of wound healing. The degree of wound healing is assessed based at least in part on the extracted information. The skin wound is treated based at least in part based on the assessed degree of wound healing. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 18/261524 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/0858 (20130101) A61B 8/5223 (20130101) Original (OR) Class Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/105 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 7/60 (20130101) G06T 2207/10132 (20130101) G06T 2207/30088 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240074754 | DREILINGER et al. |
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| APPLICANT(S) | NeuraMedica Inc. (Oregon City, Oregon) |
| ASSIGNEE(S) | NeuraMedica Inc. (Oregon City, Oregon) |
| INVENTOR(S) | Rachel DREILINGER (Oregon City, Oregon); Neil ROUNDY (Eugene, Oregon); Mariah KNIGHT (Cornelius, Oregon); Sandra BAKER (Tigard, Oregon) |
| ABSTRACT | A medical device forming method, an applier for manipulating clips, and a cartridge for holding clips are disclosed herein. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/388509 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/083 (20130101) Original (OR) Class A61B 17/1222 (20130101) A61B 2017/00584 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240074899 | Hu |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
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| INVENTOR(S) | Yang Hu (Palo Alto, California) |
| ABSTRACT | Injection of silicon oil (SO) to the anterior chamber of an eye efficiently induces intraocular pressure (TOP) elevation. This effect occurs without causing overt ocular structural damage or inflammatory responses while simulating acute glaucomatous changes that human patients develop over years by inducing progressive RGC and ON degeneration and visual functional deficits within weeks. The anterior segments of the experimental eyes are not substantially affected, leaving clear ocular elements that allow easy and reliable assessment of in vivo visual function and morphology. More importantly, this is the only reversible ocular hypertension model by removing SO from the anterior chamber and particularly useful for testing neuroprotection treatment together with lowering TOP treatment. In summary, the acute ocular hypertension glaucoma model replicates secondary post-operative glaucoma. It is straightforward and reversible, does not require special equipment or repeat injections, and may be applicable to a range of animal species with only minor modifications. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/376927 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00781 (20130101) Original (OR) Class Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075004 | BAZAN |
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| APPLICANT(S) | The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
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| INVENTOR(S) | Nicolas G. BAZAN (New Orleans, Louisiana) |
| ABSTRACT | This disclosure relates to methods of use related to omega-3 very-long-chain polyunsaturated fatty acids (n-3 VLC-PUFA) and their hydroxylated derivatives known as elovanoids to alleviate a symptom of, treat, or prevent disease. Furthermore, this invention is directed to compositions and methods for modulating VLC-PUFA bioactivity and availability. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 18/268926 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/202 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075012 | Bai et al. |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Haiqing Bai (Cambridge, Massachusetts); Longlong Si (Cambridge, Massachusetts); Rachelle Prantil-Baun (Cambridge, Massachusetts); Donald E. Ingber (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions and methods for inhibiting respiratory viral infections, inflammatory diseases, and/or respiratory inflammation. |
| FILED | Friday, August 11, 2023 |
| APPL NO | 18/448881 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/417 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/02 (20180101) A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075015 | Sahin et al. |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
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| INVENTOR(S) | Ozgur Sahin (Lexington, South Carolina); Campbell McInnes (Irmo, South Carolina); Ozge Saatci (Columbia, South Carolina); Chad Beneker (Irmo, South Carolina); Abdol-Hossein Rezaeian (Lexington, South Carolina); Metin Cetin (Columbia, South Carolina) |
| ABSTRACT | Described herein are compounds that block the activity of LOX family members having good IC50 values, no cellular toxicity below 10 μM, induce sensitization of the cells to doxorubicin, strong activity in a recombinant LOX/LOXL2 activity, and a chemical structure that is drug-like and does not have a PAINS flag, as well as, methods of treatment using the compounds with respect to cancer, organ fibrosis, neurodegenerative and cardiovascular diseases. |
| FILED | Monday, June 12, 2023 |
| APPL NO | 18/333162 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075025 | Mohsen et al. |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Al-Walid A. Mohsen (Gibsonia, Pennsylvania); Gerard Vockley (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods of treating mitochondrial fatty acid β-oxidation and/or transport disorders arising from mutant proteins in the mitochondrial fatty acid β-oxidation and transport metabolic pathways in patients are provided. The methods modulate the mitochondrial fatty acid β-oxidation pathway at the last step so that the product of the mutant protein accumulates and stabilizes the mutant protein and/or the substrate(s)/product(s) of the downstream reactions accumulate and possibly bind to allosteric sites on the mutant protein to stabilize it. Trimetazidine pharmacodynamics function as such in the β-oxidation pathway. Further, a synergistic effect is observed where a trimetazidine and PPARδ agonist combination enhanced enzyme activity and presence significantly more than either alone. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/376188 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 31/495 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 38/45 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075047 | FARESE et al. |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
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| INVENTOR(S) | Robert Vito FARESE (St. Petersburg, Florida); Mini Paliyath SAJAN (Wesley Chapel, Florida); Margaret Genevieve HIGGS (St. Petersburg, Florida) |
| ABSTRACT | Provided herein are formulations effective for and methods of treating or preventing a neurodegenerative disorder in a subject in need thereof that can include administering an amount of an aPKC inhibitor to a subject in need thereof. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506916 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) A61K 31/675 (20130101) Original (OR) Class A61K 33/242 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Enzymes C12Y 304/23046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075050 | Xiong et al. |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | University of Connecticut (Farmington, Connecticut) |
| INVENTOR(S) | Yulan Xiong (West Hartford, Connecticut); Jianzhong Yu (West Hartford, Connecticut); Qinfang Liu (Manchester, Connecticut) |
| ABSTRACT | The present invention relates to methods and compositions for treating an LRRK2-associate disorder or condition, e.g., Parkinson's Disease, methods for reducing or preventing neuronal cell death, and methods for reducing neurodegeneration and/or neuroinflammation, in a subject in need thereof, by an agent that decreases the expression of LRRK2, e.g., an agent that induces LRRK2 mRNA decay. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/226071 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7056 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075055 | Petri, JR. et al. |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); The University of Manchester (Manchester, United Kingdom) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); The University of Manchester (Manchester, United Kingdom) |
| INVENTOR(S) | William A. Petri, JR. (Charlottesville, Virginia); Alexandra N. Donlan (Seattle, Washington); Judith E. Allen (Glossop, United Kingdom); Tara Elaine Sutherland (Diggle, United Kingdom); Anthony John Day (Stockport, United Kingdom) |
| ABSTRACT | Methods for treating coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, are described. The methods can be used to reduce the severity of outcomes related to COVID-19, such as hospitalization and ventilation. For example, the methods can involve treatment of a subject with a therapeutic agent that degrades hyaluronan and/or an agent that neutralizes a hyaluronan receptor, e.g., CD44, such as an anti-CD44 antibody. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 18/269147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/728 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075062 | ROYBAL et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Kole T. ROYBAL (San Francisco, California); Raymond LIU (San Francisco, California); Iowis ZHU (San Francisco, California) |
| ABSTRACT | The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178440 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/705 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 16/32 (20130101) C07K 16/2803 (20130101) C07K 16/2878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075093 | Gourdie et al. |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
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| INVENTOR(S) | Robert G. Gourdie (Roanoke, Virginia); Zhi Sheng (Roanoke, Virginia); Kevin J. Pridham (Roanoke, Virginia); Linda Jane Jourdan (Roanoke, Virginia) |
| ABSTRACT | Described herein are compositions and formulations to treat and/or prevent a PI3K mediated disease or a symptom thereof in a subject in need thereof. In some embodiments, such compositions include engineered peptides capable of targeting PI3K or Connexin 43. Also described herein are methods of treating and/or preventing PI3K mediated disease or a symptom thereof. In some embodiments, the PI3K mediated disease is a cancer. |
| FILED | Saturday, October 09, 2021 |
| APPL NO | 18/030250 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) A61K 38/005 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075111 | Mikati et al. |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Mohamad Mikati (Durham, North Carolina); Arsen Hunanyan (Durham, North Carolina); Boris Kantor (Durham, North Carolina); Aravind Asokan (Durham, North Carolina); Ram Puranam (Durham, North Carolina); Dwight Koeberl (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides nucleic acid expression cassettes, vectors, compositions and methods for the treatment of ATPase-mediated diseases in a subject. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/340028 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/48 (20130101) Original (OR) Class A61K 48/0058 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075115 | Tuohy et al. |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
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| INVENTOR(S) | Vincent K. Tuohy (Broadview Heights, Ohio); Justin M. Johnson (Willoughby Hills, Ohio); Ritika Jaini (Cleveland, Ohio) |
| ABSTRACT | Compositions and methods for immunization against human breast cancer are disclosed. A breast cancer vaccine comprises an immunogenic polypeptide comprising human α-lactalbumin. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/063999 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 2039/545 (20130101) A61K 2039/572 (20130101) A61K 2039/812 (20180801) A61K 2039/55577 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075122 | HOANG et al. |
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| APPLICANT(S) | University of Hawaii (Honolulu, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tung HOANG (Honolulu, Hawaii); Ian A. MCMILLAN (Honolulu, Hawaii); Yun HEACOCK-KANG (Honolulu, Hawaii); Zhenxin SUN (Honolulu, Hawaii); Jan ZARZYCKI-SIEK (Honolulu, Hawaii); Michael H. NORRIS (Honolulu, Hawaii) |
| ABSTRACT | Virulence factors from Burkholderia species are provided by this invention as are antibodies specifically binding the same and methods of using the virulence factors and antibodies in methods of immunizing and treating or attenuating a Burkholderia infection. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 18/268032 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0208 (20130101) Original (OR) Class A61K 2039/522 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/1203 (20130101) C07K 2317/569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075128 | Yantasee et al. |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| INVENTOR(S) | Wassana Yantasee (Lake Oswego, Oregon); Sherif Reda (Portland, Oregon); Moataz Reda (Portland, Oregon); Worapol Ngamcherdtrakul (Portland, Oregon); Ruijie Wang (Portland, Oregon) |
| ABSTRACT | Disclosed are immunogenic constructs including: a nanoparticle; a cationic polymer electrostatically bound to an exterior surface of the nanoparticle and a stabilizer bound to the cationic polymer or the exterior surface of the nanoparticle; and an antigen or antigen producing agent. Optionally, the constructs may include adjuvant and/or one or more functional oligonucleotide(s) (e.g., siRNA or pDNA). Also disclosed are methods of using the provided immunogenic constructs for co-delivering an adjuvant, antigen, and optionally siRNA to a cell, inducing immune response in a subject, and treating or preventing an infectious disease in a subject. |
| FILED | Friday, August 18, 2023 |
| APPL NO | 18/452418 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 39/39 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 47/6923 (20170801) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075138 | Bakaletz et al. |
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| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| INVENTOR(S) | Lauren O. Bakaletz (Hilliard, Ohio); Steven D. Goodman (Hilliard, Ohio) |
| ABSTRACT | This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that are released from the biofilm by our technology are more readily cleared by the remainder of the host's immune system. |
| FILED | Friday, April 28, 2023 |
| APPL NO | 18/141270 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/64 (20130101) A61K 39/12 (20130101) A61K 39/40 (20130101) Original (OR) Class A61K 39/395 (20130101) A61K 2039/507 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 29/16 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 11/00 (20130101) A61Q 17/005 (20130101) Peptides C07K 16/12 (20130101) C07K 16/18 (20130101) C07K 16/1217 (20130101) C07K 16/1232 (20130101) C07K 16/1242 (20130101) C07K 16/1271 (20130101) C07K 16/1275 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075144 | Henry et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Curtis J. Henry (Atlanta, Georgia); Sunil S. Raikar (Decatur, Georgia); Sarwish Rafiq (Brookhaven, Georgia) |
| ABSTRACT | This disclosure relates to therapeutics containing IL-37, chimeric antigen receptors, nucleic acids, or vectors encoding the same. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering a nucleic acid or vector encoding interleukin-37 to a subject diagnosed with cancer and administering T cells expressing a chimeric antigen receptor to the subject. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering a nucleic acid or vector encoding interleukin-37 and a chimeric antigen receptor to a subject diagnosed with cancer. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 18/271364 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/4635 (20230501) A61K 39/4636 (20230501) A61K 39/464412 (20230501) Original (OR) Class A61K 2239/38 (20230501) A61K 2239/39 (20230501) A61K 2239/48 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/54 (20130101) C07K 14/55 (20130101) C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 16/2803 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075145 | HELLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loree C. HELLER (Tampa, Florida); Richard HELLER (Tampa, Florida); Mark Jeffrey JAROSZESKI (Tampa, Florida) |
| ABSTRACT | Disclosed herein are electrotransfer (ET) methods for delivering therapeutic agents to tumors. Also disclosed are methods of using the ET methods for differential delivery of an agent to more than one tissue. For example, the ET methods can be used to deliver soluble peptides of PD1 to tumor tissue to block normal PD1-PDL1 binding while separately using the ET methods to deliver PD1 or PDL1 antigen to another tissue, such as skin or muscle, to induce systemic and polyclonal checkpoint inhibitor antibodies. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/262548 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/21 (20130101) A61K 38/193 (20130101) A61K 38/195 (20130101) A61K 38/208 (20130101) A61K 38/1774 (20130101) A61K 38/2086 (20130101) A61K 41/0047 (20130101) Original (OR) Class A61K 41/0052 (20130101) A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075155 | Pachynski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Pachynski (St. Louis, Missouri); Holbrook Kohrt (Palo Alto, California); Jason Yonehiro (Palo Alto, California); Brian Zabel (Palo Alto, California) |
| ABSTRACT | The present disclosure provides compositions comprising chemerin and the methods of use thereof. The compositions of the disclosure are useful in the treatment of cancer. |
| FILED | Tuesday, May 02, 2023 |
| APPL NO | 18/311023 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) A61K 47/6813 (20170801) Original (OR) Class A61K 47/6849 (20170801) A61K 47/6869 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/52 (20130101) C07K 14/521 (20130101) C07K 14/4702 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075161 | ARBAB et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Aigusta, Georgia) |
| ASSIGNEE(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia) |
| INVENTOR(S) | Ali ARBAB (Augusta, Georgia); Mohammad Harun RASHID (Augusta, Georgia); Thaiz BORIN (Augusta, Georgia); Roxan ARA (Augusta, Georgia) |
| ABSTRACT | An engineered targeting exosome comprising; a modified Lamp2b peptide, a targeting peptide or antibody; and a Fc portion of IgG2b. The targeting peptide or antibody detects a target protein within a cell and precisely delivers the exosome to cells expressing the target protein and the Fc portion of IgGb2 induces antibody-dependent cell-mediated cytotoxicity (ADCC) events in cells expressing the target protein. Also disclosed are methods of using the engineered targeting exosome to detect and/or deplete cells expressing the target protein. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500774 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/22 (20130101) A61K 47/62 (20170801) A61K 47/6901 (20170801) Original (OR) Class Peptides C07K 14/47 (20130101) C07K 2319/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075164 | MUSUNURU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kiran MUSUNURU (Philadelphia, Pennsylvania); William H. PERANTEAU (Philadelphia, Pennsylvania); Edward MORRISEY (Newton Square, Pennsylvania) |
| ABSTRACT | A method for in utero genome editing, the method comprising administering to a subject an adenoviral vector, wherein the subject is a fetus, the adenoviral vector comprising CRISPR-mediated base editor and a guide RNA (gRNA), the gRNA targeting a mutation in a therapeutic gene; and introducing a modified codon in the therapeutic gene by base editing the therapeutic gene, wherein the base editing is performed by the adenoviral vector, an adeno-associated viral vector or lipid based nanoparticle. |
| FILED | Tuesday, April 30, 2019 |
| APPL NO | 17/052170 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/0069 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/20 (20170501) C12N 2710/10343 (20130101) C12N 2750/14143 (20130101) Enzymes C12Y 113/11027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240075170 — FLUORESCENT COMPOUND COMPRISING A FLUOROPHORE CONJUGATED TO A pH-TRIGGERED POLYPEPTIDE
| US 20240075170 | RESHETNYAK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES (Kingston, Rhode Island); YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yana K. RESHETNYAK (Saunderstown, Rhode Island); Oleg A. ANDREEV (Saunderstown, Rhode Island); Donald M. ENGELMAN (New Haven, Connecticut) |
| ABSTRACT | The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided. |
| FILED | Monday, July 10, 2023 |
| APPL NO | 18/349855 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/0082 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/04 (20130101) A61K 49/0034 (20130101) A61K 49/0056 (20130101) Original (OR) Class A61K 49/221 (20130101) A61K 49/227 (20130101) Peptides C07K 14/001 (20130101) C07K 19/00 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 69/107 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1466 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075188 | Alsberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eben Alsberg (Cleveland, Ohio); Oju Jeon (Cleveland, Ohio) |
| ABSTRACT | A method for forming a bioactive agent spatially patterned includes providing a photocrosslinkable hydrogel that includes a photocrosslinkable base polymer, photocrosslinkable bioactive agent coupling polymer macromers, and at least one bioactive agent that couples to the photocrosslinkable bioactive agent coupling polymer macromer, an selectively exposing discrete portions of the photocrosslinkable hydrogel to actinic radiation effective to initiate cross-linking of the base polymer and the bioactive agent coupling polymer macromers at the exposed portions. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/367356 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/26 (20130101) A61L 27/44 (20130101) Original (OR) Class A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/3608 (20130101) A61L 27/3834 (20130101) A61L 2300/236 (20130101) A61L 2300/252 (20130101) A61L 2300/412 (20130101) A61L 2300/414 (20130101) A61L 2400/16 (20130101) A61L 2430/40 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0084 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/002 (20130101) Derivatives of Natural Macromolecular Compounds C08H 1/06 (20130101) Compositions of Macromolecular Compounds C08L 5/04 (20130101) C08L 89/06 (20130101) C08L 2205/04 (20130101) C08L 2312/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075310 | Brady, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roscoe Brady, Jr. (Cambridge, Massachusetts); Mark Halko (Natick, Massachusetts) |
| ABSTRACT | The present disclosure describes a computerized system for a method that includes: accessing brain images of a patient, e.g., a patient who has been diagnosed with a psychotic disorder, or at high risk for developing the psychotic disorder, wherein the brain images comprise a first set of images depicting a brain structure of the patient and a second set of images encoding a brain function of the patient; generating masks based on morphing a symptom region of an atlas to the first set of images, wherein the atlas is based on a cohort of participants with the psychotic disorder; identifying treatment regions based on applying the one or more masks to the second set of images, wherein the treatment regions are specific to the patient and the symptom; and causing at least one transcranial magnetic stimulation (TMS) therapy session targeting the one or more treatment regions to be administered. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 18/256739 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) A61N 2/006 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076186 | Kondiboyina et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Vineel Kondiboyina (Somerville, Massachusetts); Christopher Miles (Acton, Massachusetts); Gregory W. Hall (Belmont, Massachusetts); Simon E. Kozin (Lexington, Massachusetts); Wolfgang Scholz (Beverly, Massachusetts); Frank Heirtzler (Londonderry, New Hampshire) |
| ABSTRACT | Systems, methods and devices for nitric oxide generation are provided for use with various ventilation and/or medical devices and having a humidity control system associated therewith. In some embodiments, a system for generating nitric oxide comprises at least one pair of electrodes configured to generate a product gas containing nitric oxide from a reactant gas, a scrubber configured to remove nitric dioxide NO2 from the product gas, and a humidity control device configured to alter a water content of at least one of the reactant gas and the product gas to control humidity within the system. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335518 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/088 (20130101) B01J 2219/0801 (20130101) B01J 2219/0809 (20130101) B01J 2219/0875 (20130101) B01J 2219/0894 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076268 | Arnaout |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Amin Arnaout (Chestnut Hill, Massachusetts) |
| ABSTRACT | The present application relates to polypeptides which are integrin antagonists. Methods of preparing the integrin antagonists and methods of treating diseases and disorders associated with abnormal levels and/or expression of one or more integrins are also provided. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/317017 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Heterocyclic Compounds C07D 211/22 (20130101) Original (OR) Class Peptides C07K 14/4703 (20130101) C07K 14/70546 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076272 | Aktas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bertal Huseyin Aktas (Newton, Massachusetts); Michael Chorev (Chestnut Hill, Massachusetts); Qingwen Zhang (Boston, Massachusetts) |
| ABSTRACT | The present application provides compounds that modulate the activity of one or more eIF2α kinases. Pharmaceutical compositions and methods of treating diseases related to one or more eIF2α kinases are also provided. |
| FILED | Thursday, October 08, 2020 |
| APPL NO | 17/766945 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 275/36 (20130101) C07C 2601/04 (20170501) C07C 2601/08 (20170501) C07C 2601/14 (20170501) Heterocyclic Compounds C07D 239/47 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076318 | CAPONE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| ASSIGNEE(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| INVENTOR(S) | Stefania CAPONE (Rome, Italy); Antonella FOLGORI (Rome, Italy); Armin LAHM (Rome, Italy); Benjamin WIZEL (Rockville, Maryland) |
| ABSTRACT | The invention provides Epstein-Barr Virus antigen polynucleotides, polypeptides and vectors; as well as immunogenic compositions comprising the same. It includes the use of Epstein-Barr Virus antigen constructs to produce vaccines for treating and preventing Epstein-Barr Virus infections and Epstein-Barr Virus-associated diseases, such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/358350 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/245 (20130101) A61K 2039/70 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076330 | BROWN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian BROWN (New York, New York); Aleksandra WROBLEWSKA (New York, New York) |
| ABSTRACT | The present invention is directed to a fusion protein comprising a scaffold protein and a series of two or more epitopes, where the distinct epitopes are recognized by distinct antibodies, and where the series of epitopes forms a detectable protein tag. The present invention further relates to a nucleic acid molecule encoding a nucleic acid sequence encoding the fusion protein, as well as vectors comprising the nucleic acid molecule. Methods of tracking a cell and kits using such vectors are also disclosed. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500881 |
| CURRENT CPC | Peptides C07K 14/43595 (20130101) Original (OR) Class C07K 14/70578 (20130101) C07K 2319/035 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1044 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076354 | Wong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Altor BioScience, LLC. (Culver City, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hing C. Wong (Weston, Florida); Peter Rhode (Miami, Florida); Bai Liu (Cooper City, Florida); Xiaoyun Zhu (Weston, Florida); Kai-Ping Han (Weston, Florida) |
| ABSTRACT | The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor α/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus). |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/498430 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/1793 (20130101) A61K 38/2086 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) Peptides C07K 14/5443 (20130101) C07K 14/7155 (20130101) Original (OR) Class C07K 16/18 (20130101) C07K 16/2887 (20130101) C07K 2317/622 (20130101) C07K 2317/732 (20130101) C07K 2319/21 (20130101) C07K 2319/22 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/09 (20130101) C12N 15/62 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076356 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark M. Davis (Atherton, California); Venkata Vamsee Aditya Mallajosyula (Palo Alto, California) |
| ABSTRACT | An antigen-specific T cell binding agent is provided, where a multivalent ‘spheromer’ system utilizes a scaffold of a self-assembling polypeptide nanoparticle, for example using selfassembling ferritin polypeptides. The system is compatible with current pMHC reagents, including both MHC-I and MHC-II molecules, and streptavidin reagents that allow ease-of-use. The spheromer assembly pipeline provides a consistent reagent across multiple batches of synthesis with ease of production. The defined geometry of the scaffold allows precise site-directed conjugation of pMHC, leading to a homogenous reagent. The spheromer binds cognate TCRs with a significantly higher avidity than a tetrameric reagent. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 18/268105 |
| CURRENT CPC | Peptides C07K 14/79 (20130101) Original (OR) Class C07K 14/70539 (20130101) C07K 2319/90 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) Enzymes C12Y 205/01078 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076360 | Song et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania); Kira Pharmaceuticals (US) LLC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenchao Song (Bryn Mawr, Pennsylvania); Takashi Miwa (Bala Cynwyd, Pennsylvania); Sayaka Sato (Philadelphia, Pennsylvania); Damodara Rao Gullipalli (Philadelphia, Pennsylvania); Ping Tsui (North Potomac, Maryland); Xihua Zhu (Jiangsu, China PRC); Jianjun Zhang (Jiangsu, China PRC); Yingying Xu (Jiangsu, China PRC) |
| ABSTRACT | This invention relates to inhibition of the complement signaling using an anti-C5 antibody or fusion protein thereof. Specifically, the invention relates to methods of treating a complement-mediated disease or complement-mediated disorder in an individual by contacting the individual with an anti-C5 antibody fusion protein thereof. |
| FILED | Friday, December 25, 2020 |
| APPL NO | 18/259106 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Peptides C07K 14/472 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/52 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076399 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin LIU (San Francisco, California); Namkyung LEE (San Francisco, California); Yang SU (San Francisco, California); Scott BIDLINGMAIER (San Francisco, California) |
| ABSTRACT | The present disclosure relates to an engineered antibody that co-engages a cell type-selective (or specific) antigen (guide) and a signaling receptor (effector) on a target cell. In some instances, the engineered antibody is capable of modulating a signaling pathway on a target cell. In other embodiments, an engineered antibody of the present disclosure is administered to a subject for the treatment of a disease or condition. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/183042 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Peptides C07K 16/30 (20130101) Original (OR) Class C07K 16/468 (20130101) C07K 16/2821 (20130101) C07K 16/2866 (20130101) C07K 2317/31 (20130101) C07K 2317/64 (20130101) C07K 2317/76 (20130101) C07K 2317/77 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076407 | ELIAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack A. ELIAS (Providence, Rhode Island); Chun Geun LEE (Woodbridge, Connecticut); Chuan Hua HE (Madison, Connecticut); Bing MA (Branford, Connecticut); Suchitra Kamle (Providence, Rhode Island); Chang-Min LEE (Warwick, Rhode Island) |
| ABSTRACT | It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for cancer, e.g., comprising an inhibitor of CHI3L1; and an inhibitor of an immune checkpoint protein. In some embodiments, the CHI3L1 inhibitor can be an antibody or antibody reagent as described herein. |
| FILED | Thursday, April 20, 2023 |
| APPL NO | 18/304327 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 16/2803 (20130101) C07K 16/2839 (20130101) C07K 2317/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076421 | Scott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy F. Scott (Ann Arbor, Michigan); Harry van der Laan (Ann Arbor, Michigan); Megan A. Cole (Ann Arbor, Michigan); Mark A. Burns (Ann Arbor, Michigan); Martin P. De Beer (Ann Arbor, Michigan); Zachary D. Pritchard (Ann Arbor, Michigan); Avi Bregman (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein is technology relating to polymerization and producing polymers and particularly, but not exclusively, to methods, systems, and compositions for producing articles using three-dimensional printing and for improving control of polymerization using a polymerization photoinhibitor having fast back reaction kinetics such as hexaarylbiimidazole compounds and bridged hexaarylbiimidazole compounds. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/389039 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/50 (20130101) Original (OR) Class C08F 4/04 (20130101) C08F 4/40 (20130101) C08F 222/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076553 | BROWN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle BROWN (Madison, Wisconsin); Song JIN (Madison, Wisconsin); Ying GE (Madison, Wisconsin); Morgan GUGGER (Champaign, Illinois) |
| ABSTRACT | The present invention provides nonionic cleavable surfactants (NCS), specifically n-Decyl-disulfide-β-D-maltoside (DSSM), suitable for MS-based proteomics and analysis. These surfactants are designed to mimic the properties of a commonly used surfactant in structural biology, n-dodecyl-β-d-maltoside (DDM), but contain a disulfide bond that allows for facile cleavage and surfactant removal before analysis. DSSM and other NCS are compatible with native mass spectrometry, top-down and bottom-up proteomics, ESI-MS and other analytical techniques, and reduce signal suppression typically observed with other surfactants. DSSM and other NCS provide versatile surfactants that can facilitate protein sample preparation under non-denaturing conditions for a myriad of proteomic and structural biology applications and act as a general replacement for DDM. |
| FILED | Thursday, August 17, 2023 |
| APPL NO | 18/451614 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 5/10 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 23/32 (20220101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076611 | Yuan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ye Yuan (Columbia, Missouri); Lee D. Spate (Columbia, Missouri); Randall S. Prather (Columbia, Missouri); R. Michael Roberts (Columbia, Missouri) |
| ASSIGNEE(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| INVENTOR(S) | Ye Yuan (Columbia, Missouri); Lee D. Spate (Columbia, Missouri); Randall S. Prather (Columbia, Missouri); R. Michael Roberts (Columbia, Missouri) |
| ABSTRACT | The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided. |
| FILED | Monday, July 24, 2023 |
| APPL NO | 18/225360 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0609 (20130101) Original (OR) Class C12N 2501/10 (20130101) C12N 2501/105 (20130101) C12N 2501/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076632 | Kawaoka et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Tokyo (Tokyo, Japan); Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoshihiro Kawaoka (Middleton, Wisconsin); Shinya Yamada (Bunkyo-ku, Japan); Shiho Chiba (Madison, Wisconsin) |
| ABSTRACT | Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation or decrease the need for HA binding to cells. |
| FILED | Tuesday, September 05, 2023 |
| APPL NO | 18/461321 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2760/16021 (20130101) C12N 2760/16022 (20130101) C12N 2760/16034 (20130101) C12N 2760/16051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076637 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard Y. Chang (Palo Alto, California); William J. Greenleaf (Stanford, California); Xingqi Chen (Stanford, California); Jason Buenrostro (Stanford, California) |
| ABSTRACT | Methods for labeling and imaging the accessible genome using a transposase are disclosed. In some embodiments, a bifunctional transposase complex or transposome is used to insert adaptors comprising chemical tags selectively at accessible sites in the genome where active regulatory DNA is located. Various chemical tags can be used for labeling DNA at insertion sites, including, for example, fluorescent dyes for fluorescence imaging, metal particles for electron microscopy or magnetic manipulation of DNA, isotopic labels, or biotin or other ligands, haptens, substrates, or inhibitors that are recognized by streptavidin, antibodies, enzymes, or receptors. Labeling DNA in this manner can be used to provide spatial information regarding the positioning of regulatory DNA in the genome and makes possible the imaging and sorting of cells based on the status of their regulatory DNA. |
| FILED | Monday, June 19, 2023 |
| APPL NO | 18/337160 |
| CURRENT CPC | Peptides C07K 1/13 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/90 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076641 | Sonnenburg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Novome Biotechnologies, Inc. (Daly City, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin L. Sonnenburg (Redwood City, California); Weston R. Whitaker (Daly City, California); Elizabeth Stanley (Portola Valley, California); William C. DeLoache (Oakland, California) |
| ABSTRACT | Compositions and methods are provided for modulating growth of a genetically modified bacterial cell present in a human organ, for modulating growth of a genetically modified bacterial cell in an organ (e.g., gut), for displacing at least a portion of a population of bacterial cells in an organ, and for facilitating gut colonization by a genetically modified bacterial cell. Also provided are genetically modified bacterial cells, e.g., cells that include a heterologous carbohydrate-utilization gene or gene set that provides for the ability to utilize as a carbon source a rare carbohydrate of interest that is utilized as a carbon source by less than 50% of bacterial cells present in a human microbiome. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501768 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/2402 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/74 (20130101) Enzymes C12Y 302/01178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076651 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); David Benjamin Turitz Cox (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Omar O. Abudayyeh (Cambridge, Massachusetts); Bernd Zetsche (Cambridge, Massachusetts); Jonathan Strecker (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a DNA-targeting Cpf1 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500232 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/62 (20130101) C12N 15/79 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2310/533 (20130101) Enzymes C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076660 | Saha et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krishanu Saha (Middleton, Wisconsin); Jared Matthew Carlson-Stevermer (Burlingame, California); Lucille Katherine Kohlenberg (Elm Grove, Wisconsin) |
| ABSTRACT | Described herein are methods of modifying a target gene in a patient or in a patient-derived cell, wherein the patient has an autosomal recessive disorder with compound heterozygous mutations, the methods including delivering a first modified guide RNA, a second modified guide RNA, a Cas9 polypeptide, a biotin-binding molecule, a first biotinylated donor polynucleotide, and a second biotinylated donor polynucleotide. The first modified guide RNA and the first biotinylated donor polynucleotide correct a first diseased allele, and the second modified guide RNA and the second biotinylated donor polynucleotide correct a second diseased allele. |
| FILED | Friday, July 07, 2023 |
| APPL NO | 18/348573 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 35/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2310/351 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076665 | Svaren |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | John Svaren (Madison, Wisconsin) |
| ABSTRACT | Regulatory elements that drive Schwann cell-specific gene expression, nucleic acid vectors, virus particles, and therapeutic compositions incorporating these constructs; and methods of using these various compositions to alter gene expression in a Schwann cell or to treat a subject having a condition associated with misexpression or insufficient function of a target gene in Schwann cells. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 18/256805 |
| CURRENT CPC | Peptides C07K 14/4713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076666 | Vance et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Eaton Vance (Albany, California); Moritz Matthias Gaidt (Berkeley, California) |
| ABSTRACT | Disclosed herein are methods of increasing or decreasing endogenous interferon amounts in subjects which comprise inhibiting, reducing, increasing, enhancing, or stabilizing MORC3 in the subjects. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/263760 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/162 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076670 | McNally |
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| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth McNally (Oak Park, Illinois) |
| ABSTRACT | Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or treating dystrophic diseases such as Limb-Girdle Muscular Dystrophy. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/481735 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076674 | Gong et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regeneron Pharmaceuticals, Inc. (Tarrytown, New York); University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Da-Wei Gong (Baltimore, Maryland); Nehal Gosalia (Tarrytown, New York); Alan Shuldiner (Tarrytown, New York); Cristopher Van Hout (Tarrytown, New York); James Perry (Baltimore, Maryland) |
| ABSTRACT | The present disclosure provides methods of treating patients having decreased bone mineral density, methods of identifying subjects having increased risk of developing decreased bone mineral density, methods of detecting human Zinc And Ring Finger 3 (ZNRF3) variant nucleic acid molecules and variant polypeptides, and ZNRF3 variant nucleic acid molecules and variant polypeptides. |
| FILED | Wednesday, June 14, 2023 |
| APPL NO | 18/334636 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076677 | Peter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcus E. Peter (Chicago, Illinois); William E. Putzbach (Lombard, Illinois); Andrea E. Murmann (Chicago, Illinois); Monal Patel (Des Plaines, Illinois); Quan Gao (Chicago, Illinois) |
| ABSTRACT | Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). The disclosed polynucleotides, compositions, and methods may be utilized for treating diseases and disorders through RNAi. Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called “death-induced by survival gene elimination” or “DISE.” |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176973 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 47/64 (20170801) A61K 47/6931 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/122 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) C12N 2320/10 (20130101) C12N 2320/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076692 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Guangping Gao (Worcester, Massachusetts); Hemant Khanna (Worcester, Massachusetts) |
| ABSTRACT | Aspects of the disclosure relate to compositions and methods useful for treating ocular ciliopathies, for example Leber congenital amaurosis (LCA). In some embodiments, the disclosure provides isolated nucleic acids comprising a transgene encoding a CEP290 protein fragment, and methods of treating ocular ciliopathies using the same. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345366 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 35/761 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076695 | Asokan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Aravind Asokan (Durham, North Carolina); Trevor Gonzalez (Durham, North Carolina); Lawrence Patrick Havlick (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides adeno-associated virus (AAV) vectors, comprising coevolved capsid variant proteins, pharmaceutical compositions, methods of making, and methods for delivering such to a subject. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/474533 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076713 | Joung et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); James Angstman (Charlestown, Massachusetts); Jason Michael Gehrke (Cambridge, Massachusetts) |
| ABSTRACT | Methodologies to detect off-target mutations induced by the deaminase activity of Base Editing technology. |
| FILED | Thursday, June 22, 2023 |
| APPL NO | 18/339788 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) Original (OR) Class C12Q 1/6855 (20130101) C12Q 1/6869 (20130101) C12Q 2521/301 (20130101) C12Q 2523/301 (20130101) C12Q 2525/191 (20130101) C12Q 2531/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076715 | Wong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Wesley Philip Wong (Cambridge, Massachusetts); Johanna Blass (Saarbruecken, Germany); Darren Yang (Somerville, Massachusetts); Clinton H. Hansen (Brighton, Massachusetts) |
| ABSTRACT | Provided herein are methods and products for detecting analytes in a sample. The analytes may be rare analytes such as biomarkers in a biological sample. These methods make use of nucleic acid nanoswitches that adopt a particular conformation and have a particular length in the presence of an analyte. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/168131 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076727 | IAFRATE et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Anthony John IAFRATE (Newton, Massachusetts); Long Phi LE (Boston, Massachusetts); Zongli ZHENG (Boston, Massachusetts) |
| ABSTRACT | The technology described herein is directed to methods of determining oligonucleotide sequences, e.g. by enriching target sequences prior to sequencing the sequences. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/459672 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6855 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 2525/155 (20130101) C12Q 2525/161 (20130101) C12Q 2525/191 (20130101) C12Q 2531/113 (20130101) C12Q 2549/119 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076734 | WALLACE et al. |
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| FUNDED BY |
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| APPLICANT(S) | OXFORD UNIVERSITY INNOVATION LIMITED (Oxford, United Kingdom) |
| ASSIGNEE(S) | OXFORD UNIVERSITY INNOVATION LIMITED (Oxford, United Kingdom) |
| INVENTOR(S) | Mark WALLACE (Oxfordshire, United Kingdom); Hagan Bayley (Oxfordshire, United Kingdom); Shuo Huang (Oxford, United Kingdom); Oliver Castell (Cardiff, United Kingdom); Mercedes Romero-Ruiz (Oxfordshire, United Kingdom) |
| ABSTRACT | The invention relates to a method for detection of analyte interaction with a channel molecule held in a membrane, comprising the optical detection of a modification in the flux of a signal molecule as it passes through the channel molecule by the action of a membrane potential, wherein the modification in the flux is caused by at least partial blockage of the channel molecule by the analyte. The invention further relates to bilayer arrays, components, methods of manufacture and use. |
| FILED | Friday, June 16, 2023 |
| APPL NO | 18/211042 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/77 (20130101) G01N 33/48721 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076736 | BAGLAENKO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Yuriy BAGLAENKO (Boston, Massachusetts); Soumya RAYCHAUDHURI (Boston, Massachusetts) |
| ABSTRACT | The disclosure provides compositions and methods for characterizing the genome and transcriptome at a single cell level. In some embodiments, the method provides for the characterization of CRISPR editing outcomes and phenotypes, as well as other alterations in polynucleotide sequences, particularly in primary cells. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/494528 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6844 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076747 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Burles Johnson (Baltimore, Maryland); Adam Aragaki (Baltimore, Maryland); David McConkey (Baltimore, Maryland); Noah Hahn (Baltimore, Maryland); Jean Hoffman-Censits (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods of determining treatment outcome in a subject having a disease, the method including evaluating RNA expression level of a B cell related gene to determine a B cell gene signature; evaluating RNA expression level of a CD8+ T cell related gene to determine a CD8+ T cell gene signature; analyzing the B cell gene signature and the CD8+ T cell gene signature (B8T gene signature); and determining treatment outcome in a subject based on the B8T gene signature. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 18/284131 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076748 | Tosar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INSTITUT PASTEUR DE MONTEVIDEO (Montevideo, Uruguay); UNIVERSIDAD DE LA REPÚBLICA (Montevideo, Uruguay); JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan Pablo Tosar (Montevideo, Uruguay); Bruno Costa (Montevideo, Uruguay); Alfonso Cayota (Montevideo, Uruguay); Kenneth Witwer (Baltimore, Maryland) |
| ABSTRACT | The present disclosure relates to a method of enzymatically repairing RNAs that are nicked or at least partially cleaved. The method comprises providing a biological sample containing RNAs that are nicked or at least partially cleaved; purifying the nicked or at least partially cleaved RNAs contained in the biological sample, under a non-denaturing condition, to remove non-RNA components; and treating the purified RNAs with at least one of the following: (i) one or more enzymes that exhibit the activity of an RNA 3′ phosphatase or cyclic phosphatase and the activity of an RNA 5′ kinase, and an RNA ligase, or (ii) a 3′-5′ RNA ligase, thereby forming repaired RNAs from the nicked or at least partially cleaved RNA. The present disclosure also relates to a method of detecting RNAs by enzymatically repairing RNAs that are nicked or at least partially cleaved, and detecting the repaired RNAs. |
| FILED | Thursday, August 24, 2023 |
| APPL NO | 18/455201 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) C12N 9/1205 (20130101) C12N 15/101 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6806 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Enzymes C12Y 207/01078 (20130101) C12Y 605/01003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076749 | BAGCHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anindya BAGCHI (San Diego, California); Ashutosh TIWARI (San Diego, California) |
| ABSTRACT | Disclosed herein are methods of diagnosing and treating MYC-driven cancers by detecting a PVT1 splice variant in a biological sample from a subject. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/503865 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077475 | BOGYO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Matthew S. BOGYO (Redwood City, California); Martijn VERDOES (Nijmegen, Netherlands); Leslie OFORI (San Diego, California); Nimali P. WITHANA (Menlo Park, California) |
| ABSTRACT | Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery. |
| FILED | Wednesday, October 18, 2023 |
| APPL NO | 18/489653 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/14 (20130101) Peptides C07K 5/06078 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 23/0066 (20130101) C09B 23/086 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/532 (20130101) Original (OR) Class G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077484 | Voronov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Roman Voronov (Oklahoma, Oklahoma); Anh Tong (Newark, New Jersey) |
| ABSTRACT | A microfluidic device capable of performing nondisruptive fluid manipulations in a living host is provided. The microfluidic device may include a combinatorial multiplexer for better scaling of multiple time points and biological signal measurements. The collected samples may be transported, stored and analyzed ex vivo for analytical ease and flexibility, e.g., by a sample analysis assay chip. The microfluidics device may include structure for maintaining fluid equilibrium within the host during the sampling to avoid damage to the host or to the implant. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508563 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0045 (20130101) A61B 2010/009 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) B01L 2200/12 (20130101) B01L 2300/023 (20130101) B01L 2300/123 (20130101) B01L 2400/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 33/6887 (20130101) G01N 33/54386 (20130101) G01N 2333/78 (20130101) G01N 2333/90206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077494 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AmberGen, Inc. (Billerica, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts) |
| ABSTRACT | The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme). |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495089 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 271/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2400/00 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077500 | Sharma |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Women and Infants Hospital of Rhode Island (Providence, Rhode Island) |
| ASSIGNEE(S) | Women and Infants Hospital of Rhode Island (Providence, Rhode Island) |
| INVENTOR(S) | Surendra Sharma (Warwick, Rhode Island) |
| ABSTRACT | The present disclosure relates in part to a blood-based method for the detection of a proteinopathy in a subject including, but not limited to, Alzheimer's disease (AD), mild cognitive impairment (MCI), and preeclampsia (PE), utilizing autophagy-deficient trophoblast (ADT) cells to sequester protein aggregates from the serum of said subject, and permit detection thereof. The present disclosure further relates to methods of treating, preventing, and/or ameliorating a proteinopathy in a subject by the administration of trehalose, a salt, solvate, stereoisomer, derivative, prodrug and or any mixture thereof. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 18/260661 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2503/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/4709 (20130101) G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077502 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); The Brigham and Women's Hospital Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); The Brigham and Women's Hospital Inc. (Boston, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Christopher J Podracky (Cambridge, Massachusetts); Chihui An (Cambridge, Massachusetts); Dominic Walsh (Boston, Massachusetts) |
| ABSTRACT | Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind recognitions motifs comprising a LMVGG [SEQ ID NO: 3] sequence. Also provided are methods (e.g., orthogonal transpeptidation and diagnostics methods) for using such sortases. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 18/271650 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Enzymes C12Y 304/2207 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/573 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/952 (20130101) G01N 2333/4709 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077563 | ZHOU et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| INVENTOR(S) | Xiaohong Joe ZHOU (Naperville, Illinois); Guangyu DAN (Chicago, Illinois); Kaibao SUN (Naperville, Illinois) |
| ABSTRACT | Magnetic resonance imaging systems and methods are provided for time-efficiently producing a plurality of image contrasts, the plurality of image contrasts including a first contrast being coupled with a second contrast and acquired over a plurality of key parameters that govern the second contrast to which the first contrast is coupled. In addition, the plurality of image contrasts is used to simultaneously map the first contrast, the second contrast, and additional contrasts. |
| FILED | Thursday, April 27, 2023 |
| APPL NO | 18/307964 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/5615 (20130101) G01R 33/56341 (20130101) Original (OR) Class G01R 33/56366 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077711 | Raub et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Christopher B. Raub (Silver Spring, Maryland); Van Kha Lam (Crofton, Maryland); George Nehmetallah (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher B. Raub (Silver Spring, Maryland); Van Kha Lam (Crofton, Maryland); George Nehmetallah (Washington, District of Columbia) |
| ABSTRACT | A microscope, a method, and a system are provided. A system includes a first optical system, a second optical system, and one or more processors. The first optical system is configured to generate an optical phase signal associated with a first image of a sample in a first field of view. The second optical system is configured to generate a polarized signal associated with a second image of the sample in a second field of view. The one or more processors is configured to generate a co-registered phase and polarization information map based on the optical phase signal and the polarized signal. The first field of view is the same as the second field of view. The first image and the second image are captured sequentially. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/075393 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/255 (20130101) G01N 21/453 (20130101) G01N 2021/1736 (20130101) Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/0092 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078287 | Walch et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arcascope Inc. (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Olivia Walch (Falls Church, Virginia); Eric Canton (Eau Claire, Wisconsin); Kevin Hannay (Comfort, Texas) |
| ABSTRACT | A goal of this invention is to minimize the cost of shifting a circadian state or entraining a state to a target cycle by identifying a preferred zeitgeber stimulus. Another goal of this invention is to provide a method to determine a person's circadian state trajectory given a stimulus time series. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/614985 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4857 (20130101) Electric Digital Data Processing G06F 17/17 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078381 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinfeng Zhang (Tallahassee, Florida); Chun-Chao Lo (Tallahassee, Florida) |
| ABSTRACT | Described herein are systems and methods for performing literature retrieval and related machine learning model training methods. An example computer-implemented method of training a machine learning model configured for literature retrieval I includes receiving a plurality of full-text articles; extracting, from the plurality of full-text articles, a plurality of positive sentence-citation pairs, each positive sentence-citation pair comprising a respective citing sentence and at least one cited article that is associated with the respective citing sentence; creating a labeled dataset comprising the plurality of positive sentence-citation pairs; and training a machine learning model using the labeled dataset. |
| FILED | Tuesday, August 29, 2023 |
| APPL NO | 18/239455 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/216 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/091 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078434 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zuwei Guo (Phoenix, Arizona); Nahid Ul Islam (Mesa, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | The system receives a plurality of medical images and integrates Self-Supervised machine Learning (SSL) instructions for performing a discriminative learning operation, a restorative learning operation, and an adversarial learning operation into a model for processing the received plurality of medical images. The model is configured with each of a discriminative encoder, a restorative decoder, and an adversarial encoder. Each of the discriminative encoder and the restorative decoder are configured to be skip connected, forming an encoder-decoder. Step-wise incremental training to incrementally train each of the discriminative encoder, the restorative decoder, and the adversarial encoder is performed, in particular: pre-training the discriminative encoder via discriminative learning; attaching the pre-trained discriminative encoder to the restorative decoder to configure the encoder-decoder as a pre-trained encoder-decoder; and training the pre-trained encoder-decoder of the model using joint discriminative and restorative learning. The pre-trained encoder-decoder is associated with the adversarial encoder. The pre-trained encoder-decoder associated with the adversarial encoder is trained through discriminative, restorative, and adversarial learning to render a trained model for the processing of the received plurality of medical images. The plurality of medical images are processed through the model using the trained model. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/241811 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0455 (20230101) G06N 3/0895 (20230101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30004 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/774 (20220101) G06V 20/50 (20220101) G06V 20/70 (20220101) G06V 2201/03 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078661 | JAFFREY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samie R. JAFFREY (New York, New York); Jacob L. LITKE (New York, New York) |
| ABSTRACT | The present invention relates to a RNA molecule comprising a first ribozyme, a first ligation sequence, an effector molecule, a second ligation sequence, and a second ribozyme. Methods of producing circular RNA molecules and treatment methods are also disclosed. |
| FILED | Thursday, July 20, 2023 |
| APPL NO | 18/355546 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7115 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/115 (20130101) C12N 2310/16 (20130101) C12N 2310/51 (20130101) C12N 2310/128 (20130101) C12N 2310/532 (20130101) C12N 2310/3519 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8851 (20130101) G01N 21/9501 (20130101) G01N 21/95607 (20130101) G01N 2021/95615 (20130101) Image Data Processing or Generation, in General G06T 7/001 (20130101) Original (OR) Class G06T 7/11 (20170101) G06T 2207/20104 (20130101) G06T 2207/30148 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078666 | PANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiaxuan PANG (Mesa, Arizona); Fatemeh Haghighi (Tempe, Arizona); DongAo Ma (Mesa, Arizona); Nahid Ui Islam (Mesa, Arizona); Mohammad Reza Hosseinzadeh Taher (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | A self-supervised machine learning method and system for learning visual representations in medical images. The system receives a plurality of medical images of similar anatomy, divides each of the plurality of medical images into its own sequence of non-overlapping patches, wherein a unique portion of each medical image appears in each patch in the sequence of non-overlapping patches. The system then randomizes the sequence of non-overlapping patches for each of the plurality of medical images, and randomly distorts the unique portion of each medical image that appears in each patch in the sequence of non-overlapping patches for each of the plurality of medical images. Thereafter, the system learns, via a vision transformer network, patch-wise high-level contextual features in the plurality of medical images, and simultaneously, learns, via the vision transformer network, fine-grained features embedded in the plurality of medical images. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/241809 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) Image or Video Recognition or Understanding G06V 10/54 (20220101) G06V 2201/03 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078671 | BUCKLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504795 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078672 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504802 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078673 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504811 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240074687 | Brunner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Peter Brunner (St. Louis, Missouri); Hohyun Cho (St. Louis, Missouri) |
| ABSTRACT | Systems and methods for detecting oscillations in neural signals are disclosed that provide for high precision and specificity in detecting neural oscillations in time and frequency domains. The disclosed systems and methods identify oscillations according to criteria including 1/f noise, number of cycles, and auto-correlation. The disclosed method detects periodic signals and filters out spurious oscillations associated with harmonic frequencies. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/193930 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/242 (20210101) Original (OR) Class A61B 5/742 (20130101) A61B 5/7225 (20130101) A61B 5/7246 (20130101) A61B 5/7253 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240074786 | Boston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Director of the Defense Health Agency (Fort Detrick, Maryland) |
| ASSIGNEE(S) | The Government of the United States, as represented by the Director of the Defense Health Agency (Fort Detrick, Maryland) |
| INVENTOR(S) | Andrew Boston (Silver Spring, Maryland); Mostafa Ahmed (Silver Spring, Maryland) |
| ABSTRACT | A kit for disposing one or more functional additives into an anatomical cavity of a patient, and particularly into the nasopharyngeal region of a patient. The functional additives may be designed to assist the patient, the doctor or both during a surgical procedure. The kit has an apparatus with a hollow deployment tube into which the functional additive may be removably disposed upon manipulation by a doctor. The kit may comprise a plurality of mutually identical or mutually different functional additives and optionally be used with surgical tampons. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936067 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3417 (20130101) Original (OR) Class A61B 2017/00238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075012 | Bai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Haiqing Bai (Cambridge, Massachusetts); Longlong Si (Cambridge, Massachusetts); Rachelle Prantil-Baun (Cambridge, Massachusetts); Donald E. Ingber (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions and methods for inhibiting respiratory viral infections, inflammatory diseases, and/or respiratory inflammation. |
| FILED | Friday, August 11, 2023 |
| APPL NO | 18/448881 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/417 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/02 (20180101) A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075191 | BURBANK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NxStage Medical, Inc. (Lawrence, Massachusetts) |
| ASSIGNEE(S) | NxStage Medical, Inc. (Lawrence, Massachusetts) |
| INVENTOR(S) | Jeffrey H. BURBANK (Manchester, Massachusetts); Dennis M. TREU (Castle Rock, Colorado); Daniel Joseph RUBERY, JR. (Nashua, New Hampshire); Scott W. NEWELL (Ipswich, Massachusetts); James M. BRUGGER (Newburyport, Massachusetts); William J. SCHNELL (Libertyville, Illinois); William K. WEIGEL (Portland, Maine); Steven A. WHITE (Hudson, Massachusetts); Mark T. WYETH (Andover, Massachusetts); Jerome JAMES (Vestavia, Alabama); David DESOUZA (Essex, Massachusetts); Joseph E. TURK, JR. (North Andover, Massachusetts); Garrett CASEY (Methuen, Massachusetts) |
| ABSTRACT | The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508533 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/34 (20130101) A61M 1/165 (20140204) A61M 1/341 (20140204) A61M 1/1605 (20140204) Original (OR) Class A61M 1/1613 (20140204) A61M 1/1615 (20140204) A61M 1/1647 (20140204) A61M 1/3403 (20140204) A61M 1/3434 (20140204) A61M 1/3437 (20140204) A61M 1/3441 (20130101) A61M 1/3444 (20140204) A61M 1/3448 (20140204) A61M 1/3607 (20140204) A61M 1/3609 (20140204) A61M 1/3635 (20140204) A61M 2205/15 (20130101) A61M 2205/058 (20130101) A61M 2205/502 (20130101) A61M 2205/702 (20130101) A61M 2205/3331 (20130101) A61M 2205/3334 (20130101) A61M 2205/3341 (20130101) A61M 2205/3351 (20130101) A61M 2205/3355 (20130101) A61M 2205/3365 (20130101) A61M 2205/3368 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075223 | Hoekman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | lmpel Pharmaceuticals Inc. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Hoekman (Seattle, Washington); Michael Hite (Normandy Park, Washington); Alan Brunelle (Woodinville, Washington); Joel Relethford (Everett, Washington) |
| ABSTRACT | A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/505101 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 15/08 (20130101) Original (OR) Class A61M 15/0021 (20140204) A61M 16/127 (20140204) A61M 16/208 (20130101) A61M 2210/0612 (20130101) A61M 2210/0618 (20130101) A61M 2210/1067 (20130101) A61M 2210/1475 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/14 (20130101) B05B 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075261 | Ahmed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as represented by the Secretary of the Department of Health Agency (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | the Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Mostafa Ahmed (Silver Spring, Maryland); Andrew Boston (Silver Spring, Maryland) |
| ABSTRACT | An apparatus that includes a conformable and compressible nasopharyngeal tampon and a method for delivering the tampon to an anatomical cavity of a patient. The tampon is configured to collect and remove posterior nasal fluid from a patient. The tampon may be compressably and slidably disposed in a longitudinally extending deployment tube having mutually opposed proximal and distal ends. A longitudinal plunger is slidably disposed within and extends out of the proximal end of the deployment tube. The distal end of the plunger is disposed in choanae and/or nasopharynx of the patient. Upon manual actuation, the plunger is activated to deliver the tampon to the nasopharyngeal region of a mammalian patient. Optionally, positioning strings may be joined to the tampon, to fine tune positioning of the tampon within the choanae and/or nasopharynx. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936056 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 31/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075268 | Sonkusale et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sameer Sonkusale (Medford, Massachusetts); Aydin Sadeqi (Medford, Massachusetts); Hojatollah Rezaei Nejad (Boston, Massachusetts); Jake Lombardo (Boston, Massachusetts); Konstantinos Tzortzakis (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides microneedles and microneedle patches for transdermal drug delivery and methods of making and using the same. The microneedles are porous and contain a drug in particulate form within the pores. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507889 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0023 (20130101) A61M 2037/0046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075414 | Kahandawala et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Moshan S. P. Kahandawala (Washington Township, Ohio); Oscar N. Ruiz (Bellbrook, Ohio) |
| ABSTRACT | The present invention relates to a reclamation and recycling process for graphene oxide, a scaffold comprising graphene oxide, a modular graphene oxide-based microbial fluid filter and a filter tool that allows the correct compression pressure of a modular filtration cartridge, and prevents internal leakage along the internal wall of the filter and thus provides correct sealing of the filter. Such modular graphene oxide-based microbial fluid filter does not require a sub-micrometer pore filtering medium, yet has a microbial filtration efficiency of up to 99.99% and the ability to filter particulates while still providing the filtration flow rates of current filters that do not employ a sub-micrometer pore filtering medium. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/235978 |
| CURRENT CPC | Separation B01D 29/03 (20130101) B01D 29/33 (20130101) B01D 29/52 (20130101) B01D 29/56 (20130101) B01D 39/2055 (20130101) Original (OR) Class B01D 2201/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075415 | Ruiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oscar N. Ruiz (Bellbrook, Ohio); Moshan S. P. Kahandawala (Washington Township, Ohio); Kurukulasuriya Fernando (Beavercreek, Ohio) |
| ABSTRACT | The present invention relates to a reclamation and recycling process for graphene oxide, a scaffold comprising graphene oxide, a modular graphene oxide-based microbial fluid filter and a filter tool that allows the correct compression pressure of a modular filtration cartridge, and prevents internal leakage along the internal wall of the filter and thus provides correct sealing of the filter. Such modular graphene oxide-based microbial fluid filter does not require a sub-micrometer pore filtering medium, yet has a microbial filtration efficiency of up to 99.99% and the ability to filter particulates while still providing the filtration flow rates of current filters that do not employ a sub-micrometer pore filtering medium. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/235981 |
| CURRENT CPC | Separation B01D 39/2055 (20130101) Original (OR) Class B01D 2201/04 (20130101) B01D 2257/91 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075440 | Chesterman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ODH IP Corp. (NEW YORK, New York) |
| ASSIGNEE(S) | ODH IP Corp. (NEW YORK, New York) |
| INVENTOR(S) | Julian Paul Chesterman (Rockville, Maryland); Kersten Rapp (Rockville, Maryland) |
| ABSTRACT | A combination crystallizer washer filter dryer device and methods of using the device for producing washed and dried product of a reaction are disclosed. The device consolidates the functions of a crystallizer with the filtering, washing, and drying steps to a single vessel, eliminating the need for an additional crystallizer separate from the filter washer dryer device, the transfer of a reaction product or crystallized product from a crystallizer to a subsequent vessel for completing the filtering, washing, and drying process of the solid phase of the slurry. |
| FILED | Tuesday, September 05, 2023 |
| APPL NO | 18/460938 |
| CURRENT CPC | Separation B01D 29/78 (20130101) B01D 29/80 (20130101) Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 27/90 (20220101) B01F 27/2312 (20220101) B01F 35/30 (20220101) B01F 35/51 (20220101) B01F 35/187 (20220101) Original (OR) Class B01F 2035/351 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075448 | Rapp et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ODH IP Corp. (New York, New York) |
| ASSIGNEE(S) | ODH IP CORP. (New York, New York) |
| INVENTOR(S) | Kersten Rapp (Rockville, Maryland); David Brancazio (Rockville, Maryland) |
| ABSTRACT | Reactor systems, reactors, and removable liners for chemical and biological processes and manufacturing modules and systems using the same, are disclosed. Kits and methods of using the reactor systems and kits as with removable elements are also disclosed. |
| FILED | Monday, September 05, 2022 |
| APPL NO | 17/929741 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/02 (20130101) B01J 19/0013 (20130101) B01J 19/18 (20130101) Original (OR) Class B01J 19/0066 (20130101) B01J 2219/00033 (20130101) B01J 2219/00094 (20130101) B01J 2219/00096 (20130101) B01J 2219/00099 (20130101) B01J 2219/00135 (20130101) B01J 2219/00141 (20130101) B01J 2219/0295 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075459 | Breshike et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Breshike (Spotsylvania, Virginia); R. Andrew McGill (Lorton, Virginia); Courtney Roberts (Sherwood Forest, California); Thomas Cao (Arlington, Virginia); Daniel A. Corbin (Arlington, Virginia) |
| ABSTRACT | The present invention provides a method of making an adsorbent material for protection and sensing applications from gas and liquid phase media by grafting sorbent moieties onto a rigid scaffold. The grafting can be to an organic linker of a metal organic framework by post synthetic modification, to the metal nodes of the metal organic framework via ligand displacement, or by intercalating the sorbent moiety into the pores of the metal organic framework either during formation of the scaffold or by diffusion into the pores after the scaffold is formed. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/241559 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) B01J 20/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075460 | Fernando et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kurukulasuriya Fernando (Beavercreek, Ohio); Oscar N. Ruiz (Bellbrook, Ohio) |
| ABSTRACT | The present invention relates to a reclamation and recycling process for graphene oxide, a scaffold comprising graphene oxide, a modular graphene oxide-based microbial fluid filter and a filter tool that allows the correct compression pressure of a modular filtration cartridge, and prevents internal leakage along the internal wall of the filter and thus provides correct sealing of the filter. Such modular graphene oxide-based microbial fluid filter does not require a sub-micrometer pore filtering medium, yet has a microbial filtration efficiency of up to 99.99% and the ability to filter particulates while still providing the filtration flow rates of current filters that do not employ a sub-micrometer pore filtering medium. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/235985 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/205 (20130101) B01J 20/3416 (20130101) B01J 20/3475 (20130101) Original (OR) Class Non-metallic Elements; Compounds Thereof; C01B 32/196 (20170801) C01B 32/198 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076032 | Sbabo |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lockheed Martin Corporation (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas L. Sbabo (Hamden, Connecticut) |
| ABSTRACT | A propeller assembly for an aircraft includes a main shaft rotatable about a propeller axis, a rotor hub mounted to the main shaft, and a plurality of blades coupled to the rotor hub. Each blade is rotatably coupled to the rotor hub for rotation about a blade rotation axis. A control system rotates each blade about the corresponding blade rotation axis and includes a ball screw coupled to the main shaft for rotation about the propeller axis and configured to translate along the propeller axis, an actuator beam mounted on the ball screw, and a ball nut coupled to the ball screw. When the ball nut rotates relative to the ball screw, the ball screw translates relative to the main shaft along the propeller axis. A differential transmission is configured to rotate the ball nut relative to the ball screw such that the ball screw is translated. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939752 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 11/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076066 | Moore et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph L. Moore (Finksburg, Maryland); Max R. Basescu (Columbia, Maryland); Adam C. Polevoy (Columbia, Maryland); Bryanna Y. Yeh (Hanover, Maryland); Luca Scheuer (Philadelphia, Pennsylvania); Kevin C. Wolfe (Lutherville, Maryland) |
| ABSTRACT | A fixed-wing unmanned aerial vehicle (UAV) includes a propeller gimbal operably coupled to the body of the UAV at the forward end and the propeller gimbal is configured to pivot the propeller about a gimbal pivot axis to change a propeller angle. A controller of the UAV may be configured to control an attitude of flight of the UAV by controlling operation of the motor, the propeller gimbal, and the control surface assembly. The controller may be further configured to determine in-flight trajectory modifications that may require high maneuverability via high angle-of-attack attitudes of flight that are implemented via the propeller gimbal and trajectories determined from a dynamics model of the fixed-wing UAV. |
| FILED | Thursday, July 06, 2023 |
| APPL NO | 18/218646 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 19/02 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 10/25 (20230101) Original (OR) Class B64U 50/13 (20230101) B64U 2101/30 (20230101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0808 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076190 | Ruiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oscar N. Ruiz (Bellbrook, Ohio); Moshan S. P. Kahandawala (Washington Township, Ohio); Kurukulasuriya Fernando (Beavercreek, Ohio) |
| ABSTRACT | The present invention relates to a reclamation and recycling process for graphene oxide, a scaffold comprising graphene oxide, a modular graphene oxide-based microbial fluid filter and a filter tool that allows the correct compression pressure of a modular filtration cartridge, and prevents internal leakage along the internal wall of the filter and thus provides correct sealing of the filter. Such modular graphene oxide-based microbial fluid filter does not require a sub-micrometer pore filtering medium, yet has a microbial filtration efficiency of up to 99.99% and the ability to filter particulates while still providing the filtration flow rates of current filters that do not employ a sub-micrometer pore filtering medium. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/235984 |
| CURRENT CPC | Separation B01D 39/2055 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Non-metallic Elements; Compounds Thereof; C01B 32/198 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076221 | Redcorn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Raymond Redcorn (Seattle, Washington); Mari-Karoliina Henriikka Winkler (Seattle, Washington); Bruce Godfrey (Seattle, Washington); David A. Stahl (Seattle, Washington) |
| ABSTRACT | Hydrogels for entrapment of live microorganisms and methods of their use, such as in wastewater purification, are disclosed. |
| FILED | Tuesday, October 13, 2020 |
| APPL NO | 17/767613 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/108 (20130101) C02F 3/341 (20130101) Original (OR) Class C02F 3/2806 (20130101) C02F 2103/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) C12N 11/12 (20130101) C12N 11/084 (20200101) C12N 11/087 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076246 | Son et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven F. Son (West Lafayette, Indiana); Caleb Nathaniel Harper (Omaha, Nebraska); Ryan Tolman Merrell (West Lafayette, Indiana); Andrew Ryan Noel (Granbury, Texas); Dhruval Natubhai Patel (West Lafayette, Indiana) |
| ABSTRACT | The combustion system includes a metal additive and a polar outer-sphere electron transferring solvent. The metal additive is solvated in the polar outer-sphere electron transferring solvent. The polar outer-sphere electron transferring solvent may include liquid ammonia, methylamine, and/or hexamethylphosphoramide. The metal additive may include an alkali metal and/or an alkaline earth metal. For instance, the metal additive may include lithium, sodium, aluminum, zirconium, titanium, yttrium, hafnium, and/or magnesium. |
| FILED | Tuesday, May 30, 2023 |
| APPL NO | 18/203486 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 33/00 (20130101) C06B 43/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076595 | INGBER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald E. INGBER (Boston, Massachusetts); Andries VAN DER MEER (Enschede, Netherlands); Anna HERLAND (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for producing and using a body having a first structure defining a first chamber, a second structure defining a second chamber, a membrane located at an interface region between the first chamber and the second chamber to separate the first chamber from the second chamber. The first chamber comprises a first permeable matrix disposed therein and the first permeable matrix comprises at least one or a plurality of lumens each extending therethrough, which is optionally lined with at least one layer of cells. The second chamber can comprise cells cultured therein. The systems and methods described herein can be used for various applications, including, e.g., growth and/or differentiation of primary cells, and/or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents). The systems and methods can also permit co-cultures of two or more different cell types. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/388300 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) C12M 25/14 (20130101) C12M 29/10 (20130101) C12M 35/08 (20130101) C12M 41/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) C12N 5/0622 (20130101) C12N 2502/081 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076654 | Banal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Banal (Cambridge, Massachusetts); Joseph Don Berleant (Cambridge, Massachusetts); Tyson Shepherd (Louisville, Colorado); Mark Bathe (Cambridge, Massachusetts) |
| ABSTRACT | Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/506027 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502792 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1068 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 35/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/60 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076749 | BAGCHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anindya BAGCHI (San Diego, California); Ashutosh TIWARI (San Diego, California) |
| ABSTRACT | Disclosed herein are methods of diagnosing and treating MYC-driven cancers by detecting a PVT1 splice variant in a biological sample from a subject. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/503865 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076791 | Pain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FABRIC8LABS, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Pain (Carlsbad, California); Andrew Edmonds (Oceanside, California) |
| ABSTRACT | An electrochemical additive manufacturing method includes coupling a first electronic device to a build plate and positioning the build plate into an electrolyte solution. The method also includes positioning a deposition anode array into the electrolyte solution, connecting the cathode portion of the build plate and one or more deposition anodes of the abide array to a power source. The method also includes transmitting electrical energy from the power source, through the one or more deposition anodes, through the electrolyte solution, and to the cathode portion of the build plate, such that material is deposited onto the cathode portion and forms at least a sidewall of a shell that encases the first electronic device against the build plate when the first electronic device is coupled to the build plate. The shell and the first electronic device form a second electronic device. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/165200 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077028 | Greene et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RTX Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | RTX Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Christopher Britton Greene (Hebron, Connecticut); James M. Donohue (Glastonbury, Connecticut); Peter AT Cocks (South Glastonbury, Connecticut) |
| ABSTRACT | A method for operating a rotating detonation engine, having a radially outer wall extending along an axis; a radially inner wall extending along the axis, wherein the radially inner wall is positioned within the radially outer wall to define an annular detonation chamber having an inlet and an outlet, wherein the method includes flowing liquid phase fuel along at least one wall of the radially inner wall and the radially outer wall in a direction from the outlet toward the inlet to cool the at least one wall and heat the liquid fuel to provide a heated liquid fuel; flowing the heated liquid fuel to a mixer at the inlet to reduce pressure of the heated liquid fuel, flash vaporize the heated liquid fuel and mix flash vaporized fuel with oxidant to produce a vaporized fuel-oxidant mixture; and detonating the mixture in the annular detonation chamber. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/388360 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/24 (20130101) F02C 7/224 (20130101) Original (OR) Class F02C 7/264 (20130101) Jet-propulsion Plants F02K 7/02 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/36 (20130101) F05D 2250/141 (20130101) F05D 2260/99 (20130101) F05D 2260/232 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/32 (20130101) F23R 3/44 (20130101) F23R 3/56 (20130101) F23R 7/00 (20130101) F23R 2900/03043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077467 | Grier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jonathan Grier (Owings Mills, Maryland); Justin Phillips (Owings Mills, Maryland); Dane Howard (Owings Mills, Maryland); Ben Marshall (Owings Mill, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Grier (Owings Mills, Maryland); Justin Phillips (Owings Mills, Maryland); Dane Howard (Owings Mills, Maryland); Ben Marshall (Owings Mill, Maryland) |
| ABSTRACT | Apparatus, systems and methods are provided that leverage plugin modules supplemented by machine learning to create a robust and adaptable forensic investigation tool that obtains data from one or more data sources, separates the data into smaller units of data (e.g., deconstructs the data into its smallest logical data items/fields) determines common data types within the smaller units, creates “edges” that match data from the one or more data sources with data already in the system, then determines potentially overlapping clusters of information to identify potential connections between investigations and displays the information on a display in link form or grid form. |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/243660 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101) Original (OR) Class Electric Digital Data Processing G06F 9/44526 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077529 | Tews et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Schweitzer Engineering Laboratories, Inc. (Pullman, Washington) |
| ASSIGNEE(S) | Schweitzer Engineering Laboratories, Inc. (Pullman, Washington) |
| INVENTOR(S) | Cody W. Tews (Portland, Oregon); Nicholas C. Seeley (Pullman, Washington) |
| ABSTRACT | The present disclosure relates to systems and methods for calculating noise distributions in an electric power system. In one embodiment, a system to calculate a noise distribution in an electric power system may comprise a measurement subsystem to obtain a plurality of raw measurements of a parameter in the electric power system. A noise distribution determination subsystem may be configured to generate a plurality of scaled raw measurements from the plurality of raw measurements, generate a power spectrum density from the plurality of scaled raw measurements, generate a cumulative distribution from the power spectrum density, and determine a noise distribution from the power spectrum density. A protective action subsystem may monitor the parameter in the electric power system to identify a signal of interest by utilizing, at least in part, the noise distribution and generating a control action in response to the signal. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/929101 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/086 (20130101) Original (OR) Class Emergency Protective Circuit Arrangements H02H 1/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078291 | Grier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jonathan Grier (Owings Mills, Maryland); Justin Phillips (Owings Mills, Maryland); Dane Howard (Owings Mills, Maryland); Ben Marshall (Owings Mill, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Grier (Owings Mills, Maryland); Justin Phillips (Owings Mills, Maryland); Dane Howard (Owings Mills, Maryland); Ben Marshall (Owings Mill, Maryland) |
| ABSTRACT | Apparatus, systems and methods are provided that create an improved forensic investigation graph. Nodes of connected data are clustered according to a maximal nearest neighbor algorithm to create maximal nearest neighbor clusters. A first node of data is directly connected to at least a second node of data and indirectly connected to a third node of data through the second node. The nearest neighbor includes only sets of nodes that are directly connected. A cluster of data includes combinations of connected nodes. A cluster of nearest neighbors only includes combinations of nodes that are directly connected to each other. The maximal nearest neighbor clusters are created by determining all clusters or nearest neighbors and removing all nearest neighbor clusters that are subsets of another nearest neighbor cluster. The maximal nearest neighbor clusters re then displayed on a display. The maximal nearest neighbor clusters represent data acquired in the performance of a forensic investigation. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/243661 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/23213 (20230101) Original (OR) Class G06F 18/24147 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078364 | Lordo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert A. Lordo (Columbus, Ohio); Paul S. Pirkle, III (Larkspur, Colorado) |
| ABSTRACT | Technologies for producing sampling and analysis plans for evaluating airborne chemical hazards are disclosed. These technologies obtain scenario data indicative of emission of an airborne chemical at a site with a human population; simulate, as a function of the scenario data, emission of the chemical at the site and transport and dispersion of a plume of the chemical across the site in space and time; assess an extent to which concentrations of the chemical in the airborne plume encounter areas containing people, as a function of time and projected human activity and movement across the site; determine, based on the simulation and assessment, recommended sampler device locations to obtain a target quality and target quantity of samples of the chemical for use in a sampling and analysis plan to determine an effect of the chemical on the human population at the site; and present the recommended sampler device locations. |
| FILED | Wednesday, September 06, 2023 |
| APPL NO | 18/242678 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/28 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240079183 | Hanrahan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brendan M. Hanrahan (Silver Spring, Maryland); Nathan S. Lazarus (Bear, Delaware) |
| ABSTRACT | Novel dielectric capacitor devices include an electrically conductive porous scaffold forming a first conductor, a conformal thin dielectric uniformly coating the pores, and a metal or alloy which fills the conformal dielectric coated pores of the scaffold forming a second conductor. This structure's design provides high surface area for high energy storage and capacitance density as well as high thermal conductivity. The metal or alloy can be a liquid metal and flowed within the device to change the electrical or mechanical properties of the device. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893350 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 7/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240079195 | Yee |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Tewksbury, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Tewksbury, Massachusetts) |
| INVENTOR(S) | Chang J. Yee (Stow, Massachusetts) |
| ABSTRACT | A tool for the removal or installation of a fuse includes a first tool arm and a second tool arm pivotally mounted to the first tool arm about an axis. A second fuse holder spreader finger section is movable away from a first fuse holder spreader finger section and a second fuse pusher finger section is movable toward a first fuse pusher finger section in response to a first handle section being moved toward a second handle section. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/388212 |
| CURRENT CPC | Tools or Bench Devices Not Otherwise Provided For, for Fastening, Connecting, Disengaging or Holding B25B 9/02 (20130101) B25B 27/0035 (20130101) Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 85/0208 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240079637 | Hersam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Kan-Sheng Chen (Chicago, Illinois); Ethan B. Secor (Chicago, Illinois) |
| ABSTRACT | An electrode for a lithium-ion battery includes a substrate; and a composite deposited on the substrate, wherein the composite comprises layered graphene comprising mono-, bi- and n-layered graphene, wherein n is an integer selected from 3-about 6; and nanoparticles of a material selected from a cathode active material and an anode active material, wherein the surface of each of said nanoparticles is coupled to and conformally coated with said layered graphene, and wherein said layered graphene is not graphene oxide and is not reduced graphene oxide. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/387509 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/139 (20130101) H01M 4/0416 (20130101) H01M 4/505 (20130101) H01M 4/625 (20130101) H01M 4/1393 (20130101) H01M 10/0525 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240075452 | LANIGAN-ATKINS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SUSTAERA INC. (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyson Lee LANIGAN-ATKINS (Durham, North Carolina); Jian Ping SHEN (Chapel Hill, North Carolina); Raghubir Prasad GUPTA (Durham, North Carolina); Cory Elliott SANDERSON (Wendell, North Carolina) |
| ABSTRACT | Processes are described for removal of CO2 from a CO2-containing gas comprising water vapor, including: (a) contacting the CO2-containing gas comprising water vapor with an alkali metal carbonate adsorbent under conditions causing (i) the water vapor in the CO2-containing gas comprising water vapor to react with the alkali metal carbonate to form a corresponding alkali metal carbonate hydrate, and (ii) the corresponding alkali metal carbonate hydrate to react with CO2 in the CO2-containing gas comprising water vapor to form a corresponding alkali metal sesquicarbonate; and (b) reacting the alkali metal sesquicarbonate under conditions effective to recover CO2 and to regenerate alkali metal carbonate hydrate adsorbent therefrom. Systems for carrying out such process are also described, which are applicable to direct air capture (DAC) of CO2, as well as to treatment of CO2-containing flue gases from power plants and other oxidation and combustion sources. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/383562 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/043 (20130101) Original (OR) Class B01J 20/3483 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075457 | LANIGAN-ATKINS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sustaera Inc. (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyson Lee LANIGAN-ATKINS (Durham, North Carolina); Jian-Peng SHEN (Chapel Hill, North Carolina); Cory Elliott SANDERSON (Wendell, North Carolina); Raghubir Prasad GUPTA (Durham, North Carolina) |
| ABSTRACT | A method for forming an integrated composite comprises providing a three-dimensional substrate having at least one channel; coating the substrate with a phenolic resin, wherein coating comprises dispersing the phenolic resin on the substrate, impregnating the phenolic resin in the substrate or a combination of both; curing the substrate and the phenolic resin; heating the cured substrate and cured phenolic resin to a temperature in a range of about 600° C. to about 1100° C. in an inert environment thereby pyrolyzing the phenolic resin, forming a conductive carbon network on, in, or both on and in the substrate; and coating a support material on, in, or both on and in the substrate to form an integrated composite. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/502262 |
| CURRENT CPC | Separation B01D 53/62 (20130101) B01D 53/82 (20130101) B01D 53/96 (20130101) B01D 2251/304 (20130101) B01D 2251/606 (20130101) B01D 2257/504 (20130101) B01D 2258/06 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/08 (20130101) B01J 20/043 (20130101) B01J 20/3078 (20130101) B01J 20/3204 (20130101) Original (OR) Class B01J 20/3234 (20130101) B01J 20/3291 (20130101) B01J 20/3433 (20130101) B01J 20/3458 (20130101) B01J 20/3483 (20130101) B01J 20/28042 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 3/0254 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075478 | Lacey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. Lacey (Idaho Falls, Idaho); Blesson Isaac (Idaho Falls, Idaho); Mark E. Small (Shelley, Idaho); Zachary P. Smith (Fort Collins, Colorado); Patrick N. Bonebright (Idaho Falls, Idaho) |
| ABSTRACT | An apparatus for removing flexible material from rotating equipment includes a cutter assembly integrated into the rotating equipment. The cutter assembly includes a cutter shaft, a cutter blade coupled to the cutter shaft, and a movement mechanism configured to move the cutter assembly along an axis of the rotating equipment to cut accumulated material from the rotating equipment. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/460434 |
| CURRENT CPC | Crushing, Pulverising, or Disintegrating in General; Milling Grain B02C 4/08 (20130101) B02C 4/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076654 | Banal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Banal (Cambridge, Massachusetts); Joseph Don Berleant (Cambridge, Massachusetts); Tyson Shepherd (Louisville, Colorado); Mark Bathe (Cambridge, Massachusetts) |
| ABSTRACT | Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/506027 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502792 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1068 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 35/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/60 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076686 | Tschaplinski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy J. Tschaplinski (Oak Ridge, Tennessee); Daniel A. Jacobson (Oak Ridge, Tennessee); David Kainer (Knoxville, Tennessee); Deborah A. Weighill (Somerville, Massachusetts); Anna K. Furches (Knoxville, Tennessee) |
| ABSTRACT | The present disclosure provides methods of producing plants with preferred levels of cell wall biosynthesis; and uses of such plants. The inventors have identified that the GFR9, CCoAOMT and MYB41 genes are major regulators of the cell wall biosynthesis pathway. Plants with modulated cell wall biosynthesis, based on modulation of the expression or activity of the GFR9, CCoAOMT and MYB41 genes, have divergent uses including pulp and paper production, and bioproduct production. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335540 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8213 (20130101) C12N 15/8218 (20130101) C12N 15/8262 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/06 (20130101) Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for D21H 11/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076700 | Deng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Shuang Deng (Richland, Washington); Jon K. Magnuson (Richland, Washington); Joonhoon Kim (Berkeley, California); Kyle R. Pomraning (Richland, Washington); Ziyu Dai (Richland, Washington); Beth A. Hofstad (Richland, Washington) |
| ABSTRACT | Recombinant Aspergillus genetically modified to increase expression of g8846, renamed herein as aconitic acid exporter (aexA), are provided, which in some examples are also genetically inactivated for an endogenous cis-aconitic acid decarboxylase (cadA) gene. Such recombinant Aspergillus produce more aconitic acid as compared to native Aspergillus. Also provided are methods of using such recombinant Aspergillus to increase production of aconitic acid and other organic acids, such as citric acid, itaconic acid, and 3-hydroxypropionic acid (3-HP). |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/493590 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/145 (20210501) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/46 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/69 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076710 | BRUNECKY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roman BRUNECKY (Arvada, Colorado); Chaiwat ENGTRAKUL (Louisville, Colorado); Carolyn Elizabeth LUBNER (Lakewood, Colorado) |
| ABSTRACT | Disclosed herein are systems, methods and compositions of matter for engineered formate dehydrogenases electrocatalytically driven in reverse to fix CO2 to formate, an electrode interface composed of self-assembled monolayers (SAM), and a nanowire link between the electrode and the enzyme's iron sulfur (FeS) cluster (engineered) to specifically link the iron sulfur cluster to the electrode. Engineering the interface between the enzyme and the electrode enables a high degree of activity and function compared to just an enzyme immobilized on the electrode. This interface enables specific orientational control of the enzyme and allows for separation of the enzyme from the electrode surface to allow retention of its native hydrodynamic radius. The transfer of electrons via the nanowire to the FeS cluster allows the enzyme to utilize its native electron transfer pathways. Moreover, wiring the FeS cluster directly to the electrode avoids the kinetic bottleneck of a soluble mediator and thus allows the wired enzyme to function more efficiently. |
| FILED | Tuesday, September 05, 2023 |
| APPL NO | 18/461351 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) Original (OR) Class Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/07 (20210101) C25B 3/26 (20210101) C25B 11/054 (20210101) C25B 11/061 (20210101) C25B 11/095 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076781 | Allen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Kristi M. Allen (Pittsburgh, Pennsylvania); Rachel D. Harris (Pittsburgh, Pennsylvania); Justin J. Martin (Harrison City, Pennsylvania); Steven J. Lemon (Lower Burrell, Pennsylvania); Silvia Bezer (Gibsonia, Pennsylvania); Mark W. McMillen (Cabot, Pennsylvania) |
| ABSTRACT | Disclosed herein are systems and methods for treating a magnesium or a magnesium alloy substrate. The system includes a cleaning composition having a pH greater than 8.5 or a solvent, and a pretreatment composition comprising an organophosphate compound and/or an organophosphonate compound. The method includes contacting a substrate surface with the cleaning composition or the solvent, and contacting the surface with the pretreatment composition. Also disclosed are substrates treated with one of the systems or methods. Also disclosed are magnesium or magnesium alloy substrates wherein, between the air/substrate interface and 500 nm below the air/substrate interface (a) oxygen and magnesium are present in a combined amount of at least 70 atomic %; (b) carbon is present in an amount of no more than 30 atomic %; and/or (c) fluoride is present in an amount of no more than 8 atomic %, wherein atomic % is measured by XPS depth profiling. |
| FILED | Monday, August 10, 2020 |
| APPL NO | 17/754568 |
| CURRENT CPC | Cleaning or Degreasing of Metallic Material by Chemical Methods Other Than Electrolysis C23G 1/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076787 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts); University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tianyu Zhang (Waltham, Massachusetts); Hui Xu (Acton, Massachusetts); Jingjie Wu (Mason, Ohio) |
| ABSTRACT | Gas diffusion electrode suitable for use in carbon dioxide electrolyzer and methods for making the same. According to one embodiment, the gas diffusion electrode may include a gas diffusion layer and a catalyst layer coupled to the gas diffusion layer. The gas diffusion layer, in turn, may include an electron-conductive domain and a non-conductive hydrophobic domain. The electron-conductive domain includes a plurality of pores. The non-conductive hydrophobic domain randomly occupies a portion of the volume of the pores of the electron-conductive domain and is, itself, sufficiently porous to permit gas transport through the electron-conductive domain, for example, by incompletely filling the pores, thereby leaving spaces in the pores, and/or by being made of an inherently porous material. The electron-conductive domain may be in the form of a metal mesh, a carbon paper, or similar structures. The non-conductive hydrophobic domain may be in the form of sintered polymer particles. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/241742 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/26 (20210101) C25B 11/032 (20210101) Original (OR) Class C25B 11/052 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076793 | Tripathy |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabhat K. Tripathy (Idaho Falls, Idaho) |
| ABSTRACT | A metal-coated article that comprises a substrate, a transition metal region adjacent to the substrate, and a platinum-group metal region adjacent to the transition metal region. The transition metal region comprises a transition metal carbide layer adjacent to the substrate. The platinum-group metal region comprises a transition metal/platinum-group metal layer that is adjacent to the transition metal region and a platinum-group metal layer adjacent to the transition metal/platinum-group metal layer. Related methods are also disclosed. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/459966 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/665 (20130101) C25D 5/10 (20130101) Original (OR) Class C25D 5/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076807 | Grappe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hippolyte A. Grappe (Oak Ridge, Tennessee); William W. Wallace (North Dighton, Massachusetts); Felix L. Paulauskas (Knoxville, Tennessee); H. Felix Wu (Frederick, Maryland); Joshua T. Brady (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hippolyte A. Grappe (Oak Ridge, Tennessee); William W. Wallace (North Dighton, Massachusetts); Felix L. Paulauskas (Knoxville, Tennessee); H. Felix Wu (Frederick, Maryland); Joshua T. Brady (Knoxville, Tennessee) |
| ABSTRACT | An apparatus is disclosed for electromagnetically and thermally treating polymeric materials, including PAN and other carbon fiber precursors at large scale at atmospheric pressure, while measuring the temperature in the closed environment of the process chamber. The apparatus is designed for continuous processing, and to be compatible with other stages of existing carbon fiber production lines. It provides direct electromagnetic coupling to the fiber tow(s) in the near-field region of one or more microwave waveguide launchers and also provides direct radiative or IR heating from susceptor plates located on the opposite side of the tow from the waveguide opening for processing a band of multiple tows of fiber. It produces low-temperature-carbonized (LTC) fiber with shorter residence time and higher density compared to the conventional process. Its design is inherently scalable to larger production. A related method is also disclosed. |
| FILED | Saturday, September 03, 2022 |
| APPL NO | 17/902818 |
| CURRENT CPC | Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/14 (20130101) Original (OR) Class Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 10/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076808 | Wallace et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William W. Wallace (North Dighton, Massachusetts); Hippolyte A. Grappe (Oak Ridge, Tennessee); Felix L. Paulauskas (Knoxville, Tennessee); H. Felix Wu (Frederick, Maryland); Truman Bonds (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William W. Wallace (North Dighton, Massachusetts); Hippolyte A. Grappe (Oak Ridge, Tennessee); Felix L. Paulauskas (Knoxville, Tennessee); H. Felix Wu (Frederick, Maryland); Truman Bonds (Knoxville, Tennessee) |
| ABSTRACT | An apparatus and method for the low temperature carbonization of a continuous tow of polymeric material fiber, such as PAN or other carbon fiber precursor materials at atmospheric pressure in an inert gas (usually nitrogen or argon) is disclosed. A pair of antennas are arranged within an electromagnetic cavity and face each other in an edgewise fashion for direct electromagnetic heating of the fiber tow as it passes between them. Supplemental background heating increases the dielectric loss of the fiber tow in order to improve absorption of electromagnetic energy and prevent arcing. The invention produces a higher density low temperature carbonized fiber in a shorter residence time compared to conventional low temperature carbonization. |
| FILED | Saturday, September 03, 2022 |
| APPL NO | 17/902815 |
| CURRENT CPC | Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077446 | SUI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yongkun SUI (Danbury, Connecticut); Madhur Bharath ATREYA (Louisville, Colorado); Gregory Lewis WHITING (Boulder, Colorado); Jenna NIELSON (Longmont, Colorado) |
| ABSTRACT | A capacitive soil moisture sensor for detecting moisture levels in soil comprises a biodegradable substrate. A capacitive circuit is positioned on the biodegradable substrate. An antenna circuit is configured to communicate capacitance data. A hydrophobic, biodegradable encapsulating material encases at least the capacitive circuit. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 18/263374 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/223 (20130101) Original (OR) Class G01N 33/246 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240079083 | Meena et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Muralikrishnan Gopalakrishnan Meena (Oak Ridge, Tennessee); Matthew J. Lane (Oak Ridge, Tennessee); Armin Guntram Geiger (Knoxville, Tennessee); Daniel Allan Jacobson (Oak Ridge, Tennessee); Joanna Tannous (Oak Ridge, Tennessee); Tomas A. Rush (Oak Ridge, Tennessee) |
| ABSTRACT | A data-driven algorithm including various network analysis routes to characterize the production of known and putative specialized metabolites and unknown analytes triggered by different exogenous compounds. Bipartite networks quantify the relationship between metabolites and treatments stimulating their production through two routes. A direct route determines the production of known and putative specialized metabolites induced by a treatment. An auxiliary route is specific for unknown analytes. Various network centrality metrics rank treatments based on their ability to trigger a broad range of specialized metabolites. The specialized metabolites are ranked based on their receptivity to various treatments. This enables tracking the influence of any exogenous treatment or abiotic factor on metabolomics output for targeted metabolite research. |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/243320 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class G16B 40/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240079605 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Qian Huang (Richland, Washington); David M. Reed (Richland, Washington) |
| ABSTRACT | A reference electrode assembly includes a reference electrode, a counter electrode, and a variable resistor. The reference electrode comprises a foil of a first metal or a foil coated with the first metal, has a width ≥0.5 mm and a length ≥the width. A surface of the reference electrode has an average roughness (Ra)≤1 μm. The counter electrode comprises a foil of a second metal or a foil coated with the second metal. The reference and counter electrodes are spaced apart. The reference electrode is configured to be electrically coupled directly or indirectly to a (−) power terminal of an external power source, and the counter electrode is configured to be electrically coupled directly or indirectly to a (+) power terminal of the external power source. The variable resistor is positioned between the external power source and either the counter electrode or the reference electrode. |
| FILED | Thursday, August 31, 2023 |
| APPL NO | 18/459322 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/92 (20130101) Original (OR) Class H01M 4/925 (20130101) H01M 8/188 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240079637 | Hersam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Kan-Sheng Chen (Chicago, Illinois); Ethan B. Secor (Chicago, Illinois) |
| ABSTRACT | An electrode for a lithium-ion battery includes a substrate; and a composite deposited on the substrate, wherein the composite comprises layered graphene comprising mono-, bi- and n-layered graphene, wherein n is an integer selected from 3-about 6; and nanoparticles of a material selected from a cathode active material and an anode active material, wherein the surface of each of said nanoparticles is coupled to and conformally coated with said layered graphene, and wherein said layered graphene is not graphene oxide and is not reduced graphene oxide. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/387509 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/139 (20130101) H01M 4/0416 (20130101) H01M 4/505 (20130101) H01M 4/625 (20130101) H01M 4/1393 (20130101) H01M 10/0525 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240079878 | PAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hitachi Energy USA Inc. (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiuping PAN (Raleigh, North Carolina); Reynaldo NUQUI (Cary, North Carolina); Liqi ZHANG (Apex, North Carolina); Anil KONDABATHINI (Apex, North Carolina); HyoJong LEE (Raleigh, North Carolina) |
| ABSTRACT | Power systems, such as transmission systems, may comprise a series capacitor bank (SCB) to provide series compensation on a power line. The SCB may be electrically inserted into the power line or bypassed according to commands sent by remote systems. Such commands may be compromised in a cyberattack to cause deteriorated conditions and instability in the power system. Thus, according to an embodiment, a protection layer is provided in an SCB station to intercept commands prior to execution, assess the consistency of the commands with a physical state of the power system, and either allow or block the commands based on the assessment, to thereby protect the SCB from cyberattacks. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902792 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/0012 (20200101) H02J 3/28 (20130101) Original (OR) Class H02J 3/00125 (20200101) H02J 13/0004 (20200101) H02J 13/00022 (20200101) H02J 2207/50 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240079947 | Du et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Wei Du (Richland, Washington); Yuan Liu (Richland, Washington); Quan Nguyen (Richland, Washington); Sheik Mohammad Mohiuddin (Richland, Washington) |
| ABSTRACT | This document describes systems and techniques for a current-limiting control strategy for single-loop droop-controlled grid-forming inverters. In aspects, a hysteresis module is configured to compare an output current detected across one or more transistors in an inverter controlled by the single-loop droop converter with a specified maximum current and to generate an overcurrent signal. The overcurrent signal presents a fault signal responsive to the output current exceeding the specified maximum current. A logic array is configured to logically combine gate control signals generated by the single-loop droop controller to selectively direct the one or more transistors to allow the output current to flow therethrough with the overcurrent signal to present modified gate control signals to the one or more transistors. The logic array is configured to replace one or more of the gate control signals in the modified gate control signals with a gate disable signal responsive to the overcurrent signal presenting the fault signal. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/241739 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/0009 (20210501) H02M 1/0012 (20210501) H02M 1/0019 (20210501) Original (OR) Class H02M 1/32 (20130101) H02M 7/5395 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240080965 | Tang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent Tang (Dublin, California); Glenn A. Meyer (Danville, California); Steven Falabella (Livermore, California); Gary Guethlein (Livermore, California); Brian Rusnak (Livermore, California); Stephen Sampayan (Manteca, California); Christopher Spadaccini (Oakland, California); Li-Fang Wang (Livermore, California); John Harris (Monterey, California); Jeff Morse (Westhampton, Massachusetts) |
| ABSTRACT | A method for producing a neutrons includes triggering a raising or a lowering of a temperature of a pyroelectric crystal of less than about 40° C. to produce a voltage of negative polarity of at least −100 keV on a surface of a deuterated or tritiated target coupled thereto. A deuterium ion source is pulsed to produce a deuterium ion beam. The accelerating of the deuterium ion beam is achieved by accelerating voltage of the pyroelectric crystal toward the deuterated or tritiated target to produce neutrons. Furthermore, the pyroelectric crystal, the deuterated or tritiated target, and the deuterium ion source are coupled to a common support. The method also includes throwing the common support housing the pyroelectric crystal, the deuterated or tritiated target, and the deuterium ion source near an unknown threat for identification thereof. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/376396 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 4/02 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 3/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240074478 | BLOCK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David BLOCK (Oakland, California); Minami OGAWA (Oakland, California) |
| ABSTRACT | Set forth herein is a composition that includes a fungal pellet and animal cells, wherein the animal cells are in connection with the fungal pellet. The animal cells can be located on the exterior surface of the fungal pellet, the interior of the fungal pellet, or both. The fungal pellet can include intact fungal cells. The fungal pellet can be substantially inviable. In an example, the pellet can be heat-treated, chemically treated, or lyophilized. The animal cells can be mammalian cells, wherein the mammalian cells may be non-human mammalian cells. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504646 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 13/424 (20160801) A23L 17/65 (20160801) A23L 31/00 (20160801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 5/0602 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/66 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240074754 | DREILINGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NeuraMedica Inc. (Oregon City, Oregon) |
| ASSIGNEE(S) | NeuraMedica Inc. (Oregon City, Oregon) |
| INVENTOR(S) | Rachel DREILINGER (Oregon City, Oregon); Neil ROUNDY (Eugene, Oregon); Mariah KNIGHT (Cornelius, Oregon); Sandra BAKER (Tigard, Oregon) |
| ABSTRACT | A medical device forming method, an applier for manipulating clips, and a cartridge for holding clips are disclosed herein. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/388509 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/083 (20130101) Original (OR) Class A61B 17/1222 (20130101) A61B 2017/00584 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240074895 | HUMAYUN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Mark S. HUMAYUN (Glendale, California); Aldo OREGON (Los Angeles, California); Yi ZHANG (Los Angeles, California) |
| ABSTRACT | Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/370098 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00727 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/24 (20130101) A61L 27/222 (20130101) A61L 27/225 (20130101) A61L 27/227 (20130101) A61L 2430/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075152 | CHMIELEWSKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jean CHMIELEWSKI (Lafayette, Indiana); Ryan CURTIS (Indianapolis, Indiana); Michael David JORGENSEN (Hoffman Estates, Illinois) |
| ABSTRACT | Supramolecular assemblies, compositions thereof, and methods for preparing and use the same are provided. The supramolecular assemblies comprise a trimeric variant of a GCN4 peptide capable of self-assembly and incorporating one or more guest molecules in a functional 3D native structure. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 18/261264 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/52 (20170801) A61K 47/64 (20170801) Original (OR) Class Peptides C07K 14/395 (20130101) C07K 2299/00 (20130101) C07K 2319/21 (20130101) C07K 2319/73 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075408 | Krajmalnik-Brown et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosa Krajmalnik-Brown (Chandler, Arizona); Srivatsan Mohana Rangan (Tempe, Arizona); Devin Bowes (Tempe, Arizona) |
| ABSTRACT | Methods and systems for the detection and quantification of multiplicity of ionic analytes comprising bromide, phosphate, sulfite, thiosulfate, thiocyanate, and formate, and optionally fluoride, chloride, chromate, selenate, perchlorate, nitrate, nitrite, and sulfate, using ion chromatography and suppressed ion conductivity. The method comprises loading a sample loop with a sample; injecting the sample from the sample loop into a column with an eluent, wherein the column comprises a guard column and an analytical column; separating, with the column, the injected sample at an effective separation temperature the injected sample in the presence of an organic modifier into a multiplicity of detectable ionic analytes; suppressing, with a suppressor, background signal; and detecting, with a detector, the multiplicity of ionic analytes. |
| FILED | Friday, August 25, 2023 |
| APPL NO | 18/456090 |
| CURRENT CPC | Separation B01D 15/363 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075475 | Ndukaife et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justus C. Ndukaife (Nashville, Tennessee); Chuchuan Hong (Nashville, Tennessee) |
| ABSTRACT | A nanotweezer includes a first electrode, a second electrode including a central region surrounded by a plurality of nanoholes, a fluidic chamber between the first electrode and the second electrode, and a voltage source configured to generate an electric field between the first electrode and the second electrode. |
| FILED | Wednesday, August 23, 2023 |
| APPL NO | 18/454285 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0654 (20130101) B01L 2400/0415 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076184 | Uddi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mruthunjaya Uddi (Tuscaloosa, Alabama); Rajagopalan Varadarajan Ranganathan (Tuscaloosa, Alabama); Steven M. Fondriest (Granville, Ohio) |
| ABSTRACT | Chemical looping reform methods comprising heating an oxygen carrier in the presence of a catalyst and plasma radicals to react the oxygen carrier with a fuel to provide a reduced oxygen carrier; and contacting the reduced oxygen carrier with water or carbon dioxide to produce hydrogen or carbon monoxide, respectively, and regenerate the oxygen carrier. The chemical looping reform methods are carried out at low temperatures such as from 150° C. to 1000° C., preferably from 150° C. to 500° C. Catalyst used in the chemical looping reform methods include a sintered rare earth metal oxide oxygen carrier and perovskite. Methods of preparing the catalyst are also provided. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505248 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/002 (20130101) B01J 23/10 (20130101) B01J 35/1014 (20130101) B01J 35/1066 (20130101) B01J 37/04 (20130101) B01J 37/08 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/40 (20130101) Original (OR) Class C01B 3/061 (20130101) C01B 2203/148 (20130101) C01B 2203/0244 (20130101) C01B 2203/0861 (20130101) C01B 2203/1058 (20130101) C01B 2203/1252 (20130101) C01B 2203/1264 (20130101) C01B 2203/1614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076188 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaodong Li (Charlottesville, Virginia); Yucheng Zhou (Charlottesville, Virginia); Zan Gao (Charlottesville, Virginia) |
| ABSTRACT | Methods and systems for producing graphene from spent lithium-ion batteries are disclosed. One method includes applying an acid leaching solution to an anode of a lithium-ion battery to produce expanded graphite, applying a hydrothermal process to the expanded graphite to produce purified graphite, and subjecting the purified graphite to a shear mixing process to produce dispersed graphene. In some examples, the shear mixing process is combined with a hydrogen passivation process, which collectively improves each of graphene quality, graphene conversion rate, and graphene production efficiency. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/273658 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/19 (20170801) Original (OR) Class C01B 32/225 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/01 (20130101) C01P 2002/72 (20130101) C01P 2004/03 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076654 | Banal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Banal (Cambridge, Massachusetts); Joseph Don Berleant (Cambridge, Massachusetts); Tyson Shepherd (Louisville, Colorado); Mark Bathe (Cambridge, Massachusetts) |
| ABSTRACT | Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/506027 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502792 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1068 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 35/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/60 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076660 | Saha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krishanu Saha (Middleton, Wisconsin); Jared Matthew Carlson-Stevermer (Burlingame, California); Lucille Katherine Kohlenberg (Elm Grove, Wisconsin) |
| ABSTRACT | Described herein are methods of modifying a target gene in a patient or in a patient-derived cell, wherein the patient has an autosomal recessive disorder with compound heterozygous mutations, the methods including delivering a first modified guide RNA, a second modified guide RNA, a Cas9 polypeptide, a biotin-binding molecule, a first biotinylated donor polynucleotide, and a second biotinylated donor polynucleotide. The first modified guide RNA and the first biotinylated donor polynucleotide correct a first diseased allele, and the second modified guide RNA and the second biotinylated donor polynucleotide correct a second diseased allele. |
| FILED | Friday, July 07, 2023 |
| APPL NO | 18/348573 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 35/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2310/351 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076748 | Tosar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INSTITUT PASTEUR DE MONTEVIDEO (Montevideo, Uruguay); UNIVERSIDAD DE LA REPÚBLICA (Montevideo, Uruguay); JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan Pablo Tosar (Montevideo, Uruguay); Bruno Costa (Montevideo, Uruguay); Alfonso Cayota (Montevideo, Uruguay); Kenneth Witwer (Baltimore, Maryland) |
| ABSTRACT | The present disclosure relates to a method of enzymatically repairing RNAs that are nicked or at least partially cleaved. The method comprises providing a biological sample containing RNAs that are nicked or at least partially cleaved; purifying the nicked or at least partially cleaved RNAs contained in the biological sample, under a non-denaturing condition, to remove non-RNA components; and treating the purified RNAs with at least one of the following: (i) one or more enzymes that exhibit the activity of an RNA 3′ phosphatase or cyclic phosphatase and the activity of an RNA 5′ kinase, and an RNA ligase, or (ii) a 3′-5′ RNA ligase, thereby forming repaired RNAs from the nicked or at least partially cleaved RNA. The present disclosure also relates to a method of detecting RNAs by enzymatically repairing RNAs that are nicked or at least partially cleaved, and detecting the repaired RNAs. |
| FILED | Thursday, August 24, 2023 |
| APPL NO | 18/455201 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) C12N 9/1205 (20130101) C12N 15/101 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6806 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Enzymes C12Y 207/01078 (20130101) C12Y 605/01003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240077778 | Clark et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Noel A. Clark (Boulder, Colorado); Xi Chen (Boulder, Colorado); Joseph E. Maclennan (Boulder, Colorado); Matthew A. Glaser (Boulder, Colorado) |
| ABSTRACT | Surface polarity of a ferroelectric nematic can be configured to generate vectorial control of the orientation of its bulk polarization field. The contact between a surface with in-plane polarity and a ferroelectric nematic liquid crystal generates preferred in-plane orientation of the ferroelectric polarization field at that interface, which can lead to the formation of fluid or glassy monodomains of high polarization without electric field poling. Materials surfaces can be used as a route to making planar-aligned cells with a variety of azimuthal director/polarization structures, including twisted states, in a π-twist cell, obtained with antiparallel, unidirectional buffing on opposing surfaces, we demonstrate three distinct modes of ferroelectric nematic electro-optic response: intrinsic viscosity-limited field induced molecular reorientation, field-induced motion of domain walls separating twisted states of opposite chirality; and propagation of polarization reorientation solitons from the cell plates to the cell center upon field reversal. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 18/270637 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/141 (20130101) Original (OR) Class G02F 1/133788 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078130 | Gopalan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kartik Gopalan (Vestal, New York) |
| ABSTRACT | A multi-hypervisor system, comprising: a plurality of hypervisors comprising a first hypervisor and a second hypervisor, at least one of the plurality of hypervisors being a transient hypervisor; and at least one Span VM, concurrently executing on each of the plurality of hypervisors, the at least one transient hypervisor being adapted to be dynamically at least one of injected and removed under the at least one Span VM concurrently with execution of the at least one Span VM on another hypervisor, wherein the at least one Span VM has a single and consistent at least one of memory space, virtual CPU state, and set of input/output resources, shared by the plurality of hypervisors. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/387053 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) Original (OR) Class G06F 2009/45562 (20130101) G06F 2009/45566 (20130101) G06F 2009/45579 (20130101) G06F 2009/45583 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078671 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504795 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078672 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504802 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078673 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504811 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078769 | Rubio-Medrano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlos Rubio-Medrano (Corpus Christi, Texas); Luis Claramunt (Gilbert, Arizona); Jaejong Baek (Chandler, Arizona); Gail-Joon Ahn (Chandler, Arizona) |
| ABSTRACT | A system implements a Policy-Governed Content Mediation Model for Mobile Augmented Reality (MAR) applications (MAR-Apps) by regulating the real-time interaction between digital MAR content, e.g., 3D objects displayed on top of a video stream, and the actual physical world. The system regulates the way MAR content is distributed inside physical spaces by means of the specification, evaluation, and enforcement of user-friendly authorization policies based on security-relevant information, a.k.a., attributes, ultimately resulting in the avoidance of unwanted content distribution and/or unwanted user interactions. Consequently, the system protects sensitive spaces as only authorized MAR content is authorized to merge with the physical surroundings. Additionally, the system allows benign multi-user interactions and respects the users' privacy by granting and enforcing management over user-supplied sensitive information. |
| FILED | Tuesday, September 05, 2023 |
| APPL NO | 18/461421 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 19/006 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 67/52 (20220501) H04L 67/131 (20220501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240080101 | Fok et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mable P. Fok (Bishop, Georgia); Qidi Liu (Athens, Georgia) |
| ABSTRACT | Various examples are provided related to single channel and multi-channel radio frequency (RF) steganography. In one example, a method includes generating an amplified spontaneous emission (ASE) broadband signal; spectrally slicing the ASE broad-band light to achieve taps for generating a dynamic photonic finite impulse response in an RF domain; generating a stealth-modulated broadband optical carrier by combining a stealth signal with the spectrally sliced ASE broadband light; passing the stealth-modulated broadband optical carrier to a dispersive medium to achieve the dynamic photonic FIR in the RF domain; and transmitting the stealth-modulated optical comb carrier via a transmission fiber. The ASE broadband light can have wavelength and intensity corresponding to background noise of a photonic system. In another example, a system for RF steganography includes a stealth transmitter. The stealth transmitter can generate and transmit the stealth-modulated optical comb carrier to a stealth receiver via a transmission fiber. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 18/271762 |
| CURRENT CPC | Transmission H04B 10/27 (20130101) Original (OR) Class H04B 2210/003 (20130101) H04B 2210/006 (20130101) H04B 2210/256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240075223 | Hoekman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | lmpel Pharmaceuticals Inc. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Hoekman (Seattle, Washington); Michael Hite (Normandy Park, Washington); Alan Brunelle (Woodinville, Washington); Joel Relethford (Everett, Washington) |
| ABSTRACT | A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/505101 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 15/08 (20130101) Original (OR) Class A61M 15/0021 (20140204) A61M 16/127 (20140204) A61M 16/208 (20130101) A61M 2210/0612 (20130101) A61M 2210/0618 (20130101) A61M 2210/1067 (20130101) A61M 2210/1475 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/14 (20130101) B05B 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078671 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504795 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078672 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504802 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240078673 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504811 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/003 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240074816 | Levin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dmitry Levin (Washington, District of Columbia); UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dmitry Levin (Washington, District of Columbia); Beth Ripley (Washington, District of Columbia); William Nylander (Washington, District of Columbia) |
| ABSTRACT | Methods, systems, and apparatuses are described for a sterilizable image manipulation device to be used in medical procedures. An orientation of the sterilizable image manipulation device may be determined and synchronized with an orientation of a virtual object. A change in the orientation of the sterilizable image manipulation device may be represented as a change in the orientation of the virtual object. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 18/270415 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/20 (20160201) Original (OR) Class A61B 90/96 (20160201) A61B 2090/3937 (20160201) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/06028 (20130101) G06K 19/06037 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 19/00 (20130101) G06T 2207/30004 (20130101) G06T 2210/41 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075047 | FARESE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Vito FARESE (St. Petersburg, Florida); Mini Paliyath SAJAN (Wesley Chapel, Florida); Margaret Genevieve HIGGS (St. Petersburg, Florida) |
| ABSTRACT | Provided herein are formulations effective for and methods of treating or preventing a neurodegenerative disorder in a subject in need thereof that can include administering an amount of an aPKC inhibitor to a subject in need thereof. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506916 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) A61K 31/675 (20130101) Original (OR) Class A61K 33/242 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Enzymes C12Y 304/23046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075167 | Goldberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey L. Goldberg (Menlo Park, California); Evan Cameron (Monkton, Maryland) |
| ABSTRACT | The present invention relates to a method for selectively transducing retinal and optic nerve head (ONH) astrocytes using adeno-associated virus serotype 5 (AAV5) in combination with a modified glial fibrillary acidic protein promoter (gfaABC1D) for delivery of gene therapies (recombinant DNA, shRNA, Crispr/Cas9) to treat glaucoma or other optic neuropathies |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/271618 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 48/0075 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240074707 | Fink |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wolfgang Fink (Tucson, Arizona) |
| ABSTRACT | Various examples are provided related to anomaly detection in sensor data (e.g., biotic or abiotic sensor data). In one example, a method includes applying data from portions of a real-time sensor signal to an artificial neural network trained to identify motifs associated with the real-time sensor signal; detecting a transition from a first motif to a second motif based upon changes in output signals providing an indication of correlation of the sensor signal to the motifs; and identifying a change in an environmental condition based upon the transition between the motifs. In another example, a method includes selecting a plurality of motifs associated with a desired training signal; generating the desired training signal by transitioning between different motifs in a pseudo-random basis; and generating training data sets from the desired training signal, which can then be utilized to train a network or other machine learning system. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 18/280395 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/318 (20210101) A61B 5/7221 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 2560/0242 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240076062 | Lozano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Paulo C. Lozano (Arlington, Massachusetts); Amelia Bruno (Boston, Massachusetts) |
| ABSTRACT | Bi-modal propulsion systems and related methods are generally described. In some embodiments, a bi-modal propulsion system may employ a single propellant for both chemical thruster(s), operating at elevated pressures, and electrical thruster(s) (e.g., electro spray thruster), operating at reduced pressures. The propellant pressure may be reduced to a desired operational range of the electrical thruster(s) using any appropriate construction including, for example, capillaries configured to reduce the pressure of the propellant to an operational range of the electrical thruster(s). In some embodiments, the reduced pressure of the propellant may be lower than a vapor pressure of at least one volatile component of the propellant, leading to the formation of “bubbles” within the propellant line. The presence of alternating gas and liquid phases along a flow path between a propellant tank and the electrical thruster(s) may help to electrically insulate the electrical thruster from the rest of the system. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 18/268686 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/26 (20130101) Original (OR) Class B64G 1/411 (20230801) B64G 1/4021 (20230801) B64G 1/4026 (20230801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240079187 — Silicon-Based Supercapacitor with Additive-Manufactured Design and Electrodes for Same
| US 20240079187 | Ready et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jud Ready (Atlanta, Georgia); Julia Allen (Atlanta, Georgia); Andrew Gunawan (Atlanta, Georgia); Aaron Thomas (Atlanta, Georgia); Deven Saurin Shah (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a wearable gait monitoring system for monitoring characteristics of an animal pulling a payload. The system can comprise and inertial measurement unit (IMU), a load sensor, and a display. The IMU can be configured to be positioned proximate the animal and configured to generate IMU data indicative of an acceleration and rotation of the animal. The load sensor can be configured to generate force data indicative of a force exerted on the payload by the animal. The display can be configured to display load and gait information to a user, wherein the load and gait information can be based on the IMU data and the force data. |
| FILED | Thursday, May 25, 2023 |
| APPL NO | 18/202231 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/26 (20130101) H01G 11/36 (20130101) Original (OR) Class H01G 11/52 (20130101) H01G 11/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240075453 | Broud et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| INVENTOR(S) | Michael Broud (Charlotte, North Carolina); David P. Harper (Maryville, Tennessee); David Keffer (Knoxville, Tennessee) |
| ABSTRACT | Carbon quantum dots having selected adsorption of carbon dioxide over nitrogen and oxygen can be prepared by amine modification or nitrogen doping of hydrocarbon-based carbon quantum dots. The carbon quantum dots can be used in various applications for the adsorption of carbon dioxide from the atmosphere and for treating industrial processes that generate carbon dioxide. The carbon quantum dots can be synthesized from lignin and can be paired with a porous activated carbon surface to create a renewable composite material with increased selective adsorption of carbon dioxide. |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/243215 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/22 (20130101) B01J 20/205 (20130101) Original (OR) Class B01J 20/28007 (20130101) B01J 20/28016 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/15 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/54 (20130101) C01P 2004/64 (20130101) C01P 2006/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240077368 | Putorti, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony Demetrio Putorti, JR. (Lovettsville, Virginia); Edward Joseph Hnetkovsky, JR. (Brunswick, Maryland) |
| ABSTRACT | A high energy arc-compatible thermal capacitance sensor includes a thermally capacitive slug comprising; a refractory insulation member on which the thermally capacitive slug is disposed; and a temperature reader disposed on a hidden thermal energy transfer surface of the thermally capacitive slug and in thermal communication with the hidden thermal energy transfer surface and that measures a temperature of the hidden thermal energy transfer surface, such that the temperature reader: is a refractory insulation member blocks the temperature reader from a plasma jet and heat flux and incident energy; and receives thermal energy from the hidden thermal energy transfer surface; and produces thermal energy data from the thermal energy, such that the heat flux and incident energy of the high energy arc event is determinable from the thermal energy data. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993537 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/026 (20130101) G01K 17/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240078795 | Fry |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark Fry (Marco Island, Florida) |
| ABSTRACT | Systems and methods of detecting a vortex made by a travelling object is disclosed. In some configurations, a graphic recognition algorithm and vortex similarity engine are used to determine whether a visual media file captured by a media collector contains a vortex. The vortex similarity engine may be configured to determine or identify certain properties about the travelling object based on the travelling object vortex. In some configurations, a computer may trigger an alert if a travelling object vortex is not expected to be in the visual media file. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/386410 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/48 (20190101) Image or Video Recognition or Understanding G06V 10/761 (20220101) G06V 10/776 (20220101) Original (OR) Class G06V 20/52 (20220101) G06V 2201/08 (20220101) Traffic Control Systems G08G 5/0078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20240077426 | Deng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State Unioversity (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yiming Deng (Okemos, Michigan); Mohand Alzuhiri (East Lansing, Michigan) |
| ABSTRACT | An inspection tool includes a projector projecting a projected pattern on a cylindrical surface, a first camera generating a first image of the projected pattern and a controller generating a surface profile of the cylindrical surface based on the first image. |
| FILED | Sunday, August 27, 2023 |
| APPL NO | 18/238502 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240078503 | Bornitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carrie Ann Bornitz (Sioux Falls, South Dakota); Robert E. Dixon, JR. (Haymarket, Virginia); Ryan M. Luckay (Vienna, Virginia) |
| ABSTRACT | Systems and methods of creating, managing, and distributing supplemental content associated with items in a distribution network. A physical delivery item can be imaged and associated with additional content generated or associated with the sender of the physical delivery item. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495197 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240074917 | Ahmed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as represented by the Secretary of the Department of Health Agency (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mostafa Ahmed (Silver Spring, Maryland); Andrew Boston (Silver Spring, Maryland) |
| ABSTRACT | A kit for disposing a surgical tampon into an anatomical cavity of a patient, and particularly in the nasopharyngeal region of a patient. The kit has an apparatus with a hollow deployment tube into which a compressible tampon may be removably disposed upon manipulation by a doctor. The tampon may have one or more associated functional additives to assist the doctor or patient with a surgical procedure. The kit may comprise a plurality of mutually identical or mutually different surgical tampons. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936061 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/266 (20130101) Original (OR) Class A61F 13/2005 (20130101) A61F 13/2074 (20130101) A61F 2013/2014 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/20 (20130101) A61L 15/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240074918 | Boston et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as represented by the Secretary of the Department of Health Agency (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Boston (Silver Spring, Maryland); Mostafa Ahmed (Silver Spring, Maryland) |
| ABSTRACT | A conformable surgical tampon for disposition into and removal from an anatomical cavity of a mammalian patient by a doctor to absorb and collect bodily fluids. The tampon comprises an absorbent chassis material and a plurality of spaced apart positioning strings attached to the chassis. The spaced apart positioning strings are operative to selectively position the conformable nasopharyngeal tampon within an anatomical cavity of a patient responsive to manipulation of a positioning string by a surgeon. The tampon is particularly suited for nasopharyngeal surgery. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/954462 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/266 (20130101) Original (OR) Class A61F 13/2005 (20130101) A61F 13/2074 (20130101) A61F 13/2077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240075264 | Ahmed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as represented by the Secretary of the Department of Health Agency (Wright-Petterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mostafa Ahmed (Silver Spring, Maryland); Andrew Boston (Silver Spring, Maryland) |
| ABSTRACT | An apparatus that for delivering a conformable and compressible nasopharyngeal tampon to an anatomical cavity of a patient and method of delivering the tampon to the patient. The tampon is configured to collect and remove posterior nasal fluid from a patient. The tampon may be compressably and slidably disposed in a longitudinally extending deployment tube having mutually opposed proximal and distal ends. A longitudinal plunger is slidably disposed within and extends out of the proximal end of the deployment tube. The distal end of the plunger is disposed in choanae and/or nasopharynx of the patient. Upon manual actuation, the plunger is activated to deliver the tampon to the nasopharyngeal region of a mammalian patient. Optionally, positioning strings may be joined to the tampon, to fine tune positioning of the tampon within the choanae and/or nasopharynx. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936038 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 35/006 (20130101) Original (OR) Class A61M 2210/0618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, March 07, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240307.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page