FedInvent™ Patent Applications
Application Details for Thursday, March 14, 2024
This page was updated on Tuesday, June 18, 2024 at 02:16 PM GMT
Department of Health and Human Services (HHS)
| US 20240081300 | Patel et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Manoj K. Patel (Charlottesville, Virginia); Ian C. Wenker (Charlottesville, Virginia); Eric R. Wengert (Charlottesville, Virginia) |
| ABSTRACT | Provided are compositions and methods for treating and/or preventing seizure-induced death in subjects in need thereof. In some embodiments, the methods include methods for inducing an audiogenic seizure and/or seizure-induced death, treating and/or preventing death associated with seizures in subjects, preventing sudden unexpected death in epilepsy (SUDEP) in subjects, preventing and/or reducing the risk of death in subjects having SCN8A gain-of-function mutations, preventing or reducing the risk of death associated with tonic seizures in subjects, and preventing or reducing the risk of death associated with epileptic seizures in subjects. Also provided are animals that have been modified to carry gain-of-function SCN8A mutations and methods for using the same to identify compounds that have activity in treating and/or preventing seizures and/or seizure-induced death in subjects. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 18/271911 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Original (OR) Class A01K 2217/072 (20130101) A01K 2227/105 (20130101) A01K 2267/0356 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240081636 | SKERSWETAT et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jan SKERSWETAT (Cambridge, Massachusetts); Peter John BEX (Concord, Massachusetts) |
| ABSTRACT | Testing methods for evaluating visual and neurological functions of a human or animal subject that involve conscious perception. The tests include a training phase, a practice phase, and a visual rivalry phase for detecting binocular rivalry or multistate competition. The design of the testing methods offers simple, rapidly administered, nonverbal visual testing with high time resolution and access to changing conscious perceptual states of the test subject. The methods also make possible the collection of a large amount of data in a short time for analysis of the subjects visual function and brain function, and can be used in the diagnosis of many medical conditions. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/274253 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/08 (20130101) Original (OR) Class A61B 5/4088 (20130101) A61B 5/7475 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240081642 | TOTH et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cynthia TOTH (Durham, North Carolina); Kai SEELY (Durham, North Carolina); Vincent TAI (Durham, North Carolina); Stephanie CHIU (Durham, North Carolina); Katrina WINTER (Durham, North Carolina); Ryan IMPERIO (Durham, North Carolina) |
| ABSTRACT | A retinal vessel shadow view optical coherence tomography (RVSV-OCT) image can be created by receiving, at an enhanced OCT processing system, volumetric OCT scan of a patient. The system can segment the volumetric OCT scan to determine layer boundaries and delineate a boundary of interest based on the determined layer boundaries of the segmented volumetric OCT scan. En face vascular information can be extracted to create an RVSV-OCT image by determining a first offset from the boundary of interest and a second offset from the boundary of interest; extracting volumetric data from an area between the first offset and the second offset to create a three-dimensional volume; and identifying a two-dimensional surface from the three-dimensional volume, the two-dimensional surface being the RVSV-OCT image. The RVSV-OCT image can be provided for analysis, for example, to evaluate retinal vascular disease in preterm infants at risk for retinopathy of prematurity. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/767776 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/102 (20130101) A61B 3/1225 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/12 (20170101) G06T 2207/10101 (20130101) G06T 2207/20081 (20130101) G06T 2207/30041 (20130101) G06T 2207/30101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240081728 | Kiapour et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); Rhode Island Hospital (Providence, Rhode Island) |
| INVENTOR(S) | Ata Kiapour (Wayland, Massachusetts); Braden C. Fleming (Sherborn, Massachusetts); Martha M. Murray (Sherborn, Massachusetts) |
| ABSTRACT | Described herein are techniques to aid clinicians and researchers in determining a condition of connective tissue as it relates to tissue development, growth and maturation, tissue remodeling and healing following injury, and risk of injury based on a magnetic resonance (MR) image of the tissue. Such techniques may be useful to clinicians by providing insights on factors that influence the growth and maturation of connective tissues as well as those that impact the risk of connective tissue injury and response to treatment. These insights can be used in a variety of ways, including to guide or develop patient specific risk assessment and prevention strategies, treatment plans, and postoperative care plans for individuals at risk of connective tissue injuries and those with injured connective tissues, such as an anterior cruciate ligament (ACL) injury. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 18/274279 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4533 (20130101) Original (OR) Class A61B 5/4585 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240081735 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yuanting Zhang (Hong Kong, China PRC); The General Hospital Corporation (Boston, Massachusetts) |
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| INVENTOR(S) | Quan Zhang (Winchester, Massachusetts); Yuanting Zhang (Hong Kong, China PRC) |
| ABSTRACT | A system and method for measuring and monitoring blood pressure is provided. The system includes a wearable device and a tonometry device coupled to the wearable device. The Tonometry device is configured to compress a superficial temporal artery (STA) of a user. A sensor pad is attached to the wearable device adjacent the tonometry device. A blood pressure sensor is integrated within the sensor pad for continuous, unobtrusive blood pressure monitoring. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/388117 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/022 (20130101) A61B 5/026 (20130101) A61B 5/33 (20210101) A61B 5/0245 (20130101) A61B 5/742 (20130101) A61B 5/02125 (20130101) A61B 5/6803 (20130101) Original (OR) Class A61B 5/7278 (20130101) A61B 5/7282 (20130101) A61B 2562/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240081759 | TICHAUER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth M. TICHAUER (Chicago, Illinois); Scott C. DAVIS (Woodville, New Hampshire); Brian William POGUE (Hanover, New Hampshire) |
| ABSTRACT | An apparatus and method for medical imaging uses a first and second contrast agent, the second agent targeted to a particular tissue type. First images are obtained using the first agent, and second images using the second agent using medical imaging systems. An image processing system is adapted to process the first and second medical images by fitting parameters of a pharmacokinetic model to the first medical images, identifying a nontargeted tissue type, scaling the fitted parameters to best match the nontargeted tissue in the second medical images, executing the pharmacokinetic model to prepare a correction image, and generating corrected medical images by subtracting the correction image from the second medical images. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/389128 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 6/032 (20130101) A61B 6/037 (20130101) A61B 6/481 (20130101) Original (OR) Class A61B 6/4417 (20130101) A61B 6/5235 (20130101) A61B 6/5247 (20130101) Image Data Processing or Generation, in General G06T 5/50 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/20224 (20130101) G06T 2207/30024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082053 | Feinberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Walter Feinberg (Pittsburgh, Pennsylvania); Rachelle Simko (Pittsburgh, Pennsylvania) |
| ABSTRACT | A process for micro-tissue encapsulation of cells includes coating a tissue scaffold stamp with an extracellular matrix compound. The process includes depositing the tissue scaffold stamp onto a thermoresponsive substrate and seeding the tissue scaffold stamp with a cell culture. A cell culture forms a cell patch that is attached to the extracellular matrix compound. A monolayer on the tissue scaffold stamp for which borders of the monolayer maintain expressions for cell-cell junctions, wherein the cell-cell junctions of the monolayer are configured to express tension forces. The process includes removing the thermoresponsive substrate. The process includes folding the micro-tissue structure by suspending the micro-tissue in the solvent. The folded micro-tissue structure is collected from the solvent and administered to an organism. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 17/769626 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0017 (20130101) Original (OR) Class A61F 2250/0067 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/34 (20130101) A61L 27/507 (20130101) A61L 27/3633 (20130101) A61L 27/3808 (20130101) A61L 2300/62 (20130101) A61L 2300/64 (20130101) A61L 2300/414 (20130101) A61L 2430/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082104 | Johnson et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Austin Johnson (Sacramento, California); Jason Adams (Sacramento, California); Jean-Pierre Delplanque (Davis, California); Justin Koos (Sacramento, California); Gregory Rehm (Davis, California) |
| ABSTRACT | Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/388711 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/742 (20130101) A61B 5/7203 (20130101) A61B 5/7264 (20130101) A61B 5/7282 (20130101) A61B 5/7405 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 31/00 (20130101) Original (OR) Class A61H 2201/5023 (20130101) A61H 2201/5087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082108 | Gielen et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Gielen (Ellicott City, Maryland); Soraya J. Bailey (Baltimore, Maryland); Eileen M. McDonald (Baltimore, Maryland); Nathan W. Scott (Baltimore, Maryland); Christopher Dykes (Baltimore, Maryland) |
| ABSTRACT | Prescription medications, especially opioids, are often abused. The present invention provides a pill dispensing device that is designed to reduce misuse, diversion, and pilfering or prescribed opioids or other medications that may require regulated dispensing. The device of the present invention securely holds a repository of pills and dispenses a single pill only after the allotted prescribed time interval and only after verification of the correct user through the biometric ID device. The dispensing device includes a locked tamper-resistant outer housing, a biometric ID device, a display for alerting the user to critical information, (such as time to the next pill and number of pills remaining) and a secure mechanical pill dispensing mechanism. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 18/263644 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/03 (20130101) A61J 1/1437 (20130101) Original (OR) Class A61J 7/0076 (20130101) A61J 7/0481 (20130101) A61J 2200/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082158 | ACHARYA et al. |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Abhinav Prakash ACHARYA (Pittsburgh, Pennsylvania); Stephen Yu-Wah CHAN (Pittsburgh, Pennsylvania); Steven R. LITTLE (Allison Park, Pennsylvania) |
| ABSTRACT | Disclosed are compositions comprising a YAP1/WWRT1 inhibiting agent and a glutaminase inhibiting agent and methods of their use. Disclosed herein are therapeutic particles comprising a biocompatible polymer, a YAP1/WWRT1 inhibiting agent, and a glutaminase inhibiting agent. In one aspect, disclosed herein are methods of treating a pulmonary disease in a subject in need of such treatment comprising administering the therapeutic particle to the subject. |
| FILED | Tuesday, July 11, 2023 |
| APPL NO | 18/350304 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1647 (20130101) Original (OR) Class A61K 31/409 (20130101) A61K 31/473 (20130101) A61K 31/501 (20130101) A61K 31/4545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082177 | Rubin et al. |
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| FUNDED BY |
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| APPLICANT(S) | MESHABERASE, LLC (Potomac, Maryland); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | MESHABERASE, LLC (Potomac, Maryland); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Benjamin Rubin (Potomac, Maryland); Mark Gilbert (Bethesda, Maryland); Jinkyu Jung (Bethesda, Maryland) |
| ABSTRACT | The present Disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or a derivative thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506386 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/28 (20130101) A61K 9/0053 (20130101) A61K 9/4891 (20130101) A61K 31/145 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082183 | Reddy |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
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| INVENTOR(S) | Pavan Reddy (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are compositions and methods for preventing, attenuating or treating T cell mediated intestinal disorders. In particular, provided herein are methods for preventing, attenuating or treating T cell mediated intestinal disorders characterized with reduced intestinal epithelial cell (IEC) specific mitochondrial complex II component intrinsic succinate dehydrogenase A (SDHA) activity and/or expression through use of compositions comprising a therapeutic agent capable of preventing and/or hindering reduction of IEC related SDHA activity and/or expression. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 18/271102 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082195 | Nobile et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clarissa J. Nobile (Merced, California); Megha Gulati (Merced, California) |
| ABSTRACT | The disclosure provides compositions comprising amino acids, individually and in combination, and methods of making the compositions and methods of using the compositions as pharmaceutically active agents to, inter alia, treat disease in animals, including humans. |
| FILED | Thursday, September 21, 2023 |
| APPL NO | 18/371085 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/133 (20130101) A61K 31/198 (20130101) Original (OR) Class A61K 31/401 (20130101) A61K 31/405 (20130101) A61K 31/661 (20130101) A61K 31/4172 (20130101) A61K 47/08 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082198 | HILL et al. |
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| FUNDED BY |
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| APPLICANT(S) | EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. (Gaithersburg, Maryland) |
| INVENTOR(S) | Daniel Cope HILL (Gaithersburg, Maryland); Anthony M. TRESTON (Gaithersburg, Maryland) |
| ABSTRACT | This disclosure describes a composition comprising an alkyl nitrite, such as isoamyl nitrite, and an effective amount of at least one stabilizing compound, such as one or more of vitamins K1, K2, and K3. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 18/246982 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/21 (20130101) Original (OR) Class A61K 31/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082210 | Lopez-Mejias et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vilmali Lopez-Mejias (San Juan, Puerto Rico); Jeaninna P. Flores Bello (San Juan, Puerto Rico); Israel Rodriguez Rodriguez (San Juan, Puerto Rico); Joyce Marie Serrano Valcarcel (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vilmali Lopez-Mejias (San Juan, Puerto Rico); Jeaninna P. Flores Bello (San Juan, Puerto Rico); Israel Rodriguez Rodriguez (San Juan, Puerto Rico); Joyce Marie Serrano Valcarcel (San Juan, Puerto Rico) |
| ABSTRACT | A series of pharmaceutical metal complexes (pMCs) were produced and characterized using the mast cell stabilizer, cromolyn, and bioactive metal ions (Zn+2, Mg+2, and Ca+2). Three novel pMCs, Cromolyn-Zn, Cromolyn-Mg, and Cromolyn-Ca were formed through reactions under controlled temperature and pH conditions. TGA demonstrated that these metal complexes showed an enhanced thermal stability due to the strong coordination with the ligand, cromolyn. PXRD data indicates a high degree of crystallinity as well as a unique packing arrangement for each pMCs. SEM analysis showed materials with well-defined morphologies while EDS presented elemental evidence for the unique composition of each pMCs. The crystal structure for these materials was elucidated through SCXRD, and a variety of binding modes and packing motifs were found within each respective metal complex. Only 2D structures were achieved under the conditions studied. Dissolution studies show high stability and slow degradation for the metal complexes, while a higher dissolution was observed for the drug compound in PBS. Neither CS nor the pMCs dissolved significantly in FaSSGF at 37° C. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/515252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082211 | Corson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy William Corson (Fishers, Indiana); Rania Sulaiman (Indianpolis, Indiana) |
| ABSTRACT | Methods of using compounds to inhibit ocular disease are disclosed herein. Methods are disclosed for inhibiting soluble epoxide hydrolase (sEH) for the treatment of ocular diseases, and in particular, retinopathy of prematurity (ROP) or diabetic retinopathy. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/512376 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 9/0053 (20130101) A61K 31/192 (20130101) A61K 31/353 (20130101) Original (OR) Class A61K 31/423 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082215 | GASPARINI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Novartis AG (Basel, Switzerland); Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Novartis AG (Basel, Switzerland); Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Fabrizio GASPARINI (Basel, Switzerland); Baltazar GOMEZ-MANCILLA (Basel, Switzerland); John KRYSTAL (New Haven, Connecticut); Vincent MALATERRE (Basel, Switzerland); Stephanie O'MALLEY (New Haven, Connecticut); Godfrey PEARLSON (New Haven, Connecticut); Marc POTENZA (New Haven, Connecticut) |
| ABSTRACT | The present invention relates to the use of mavoglurant in the treatment of gambling disorder. The present invention also relates to the use of mavoglurant in the treatment of gaming disorder. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 18/266917 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082221 | Nociari |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Marcelo M. Nociari (Summit, New Jersey) |
| ABSTRACT | The present disclosure provides compositions and methods for treating eye diseases (e.g., retinopathies), and more particularly, eye diseases associated with cytotoxic lipofuscin-associated cytotoxicity in retinal cells. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 18/273678 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/47 (20130101) A61K 31/427 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/635 (20130101) A61K 31/4545 (20130101) A61K 31/4985 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5038 (20130101) G01N 33/5044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082232 | LU et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen LU (Pearland, Texas); Robert C. BAST, JR. (Houston, Texas) |
| ABSTRACT | Provided are methods of treating cancer comprising administering to a patient in need thereof a poly (ADP-ribose) polymerase (PARP) inhibitor and a salt-induced kinase 2 (SIK2) inhibitor. Also provided are methods for increasing the duration of remission for cancer, and for enhancing the sensitivity of PARP inhibitors for cancer. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/469467 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) Original (OR) Class A61K 31/502 (20130101) A61K 31/5025 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082238 | Salem et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Aliasger K. Salem (Iowa City, Iowa); Kareem Ebeid (Iowa City, Iowa); Youssef Wahib Naguib Ibrahim (Iowa City, Iowa); Sanjib Saha (Iowa City, Iowa); Emad I. Wafa (Iowa City, Iowa); Suhaila Alhaj-Suliman (Iowa City, Iowa) |
| ABSTRACT | The invention provides methods, compositions, and kits that are useful for treating cancer (e.g., endometrial cancer). |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890757 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1647 (20130101) A61K 31/337 (20130101) A61K 31/495 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082246 | Aguilar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Ruben Claudio Aguilar (West Lafayette, Indiana) |
| ABSTRACT | A combination of active agents for the treatment of Lowe Syndrome (LS) comprising a RhoA inhibitor and a mTOR inhibitor; a pharmaceutical composition comprising the combination and a pharmaceutically acceptable carrier; a combination of pharmaceutical compositions in which one composition comprises a RhoA inhibitor and the other composition comprises a mTOR inhibitor; and a method of treating a patient for LS. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/389574 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 31/505 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082250 | D'Aquila et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Thomas D'Aquila (Evanston, Illinois); Chisu Song (Evanston, Illinois); Isabelle Clerc (Evanston, Illinois); Cristina Vaca (Evanston, Illinois); Aubrey Sawyer (Evanston, Illinois) |
| ABSTRACT | Disclosed is a method for the treatment of a subject having an HIV infection or inhibiting neddylation using a neddylation inhibiting enzyme, neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8)-activating enzyme E1 (NAE1). |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/467698 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082252 | Robertson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gavin R. Robertson (Hummelstown, Pennsylvania); Raghavendragowda Gowda Chandagalu Doreswamy (Hershey, Pennsylvania); Omer F. Kuzu (Hershey, Pennsylvania); Arati K. Sharma (Hummelstown, Pennsylvania); Gregory Kardos (Phoenixville, Pennsylvania); Subbarao V. Madhunapantula (Karnataka, India); Mohammed A. Noory (Hershey, Pennsylvania); Joseph J. Drabick (Palmyra, Pennsylvania) |
| ABSTRACT | Compositions and methods continue to be required for treatment of cancer. Compositions and methods according to aspects of the present invention relate to inhibition of a combination of kinases for treatment of cancer, specifically inhibition of both AKT and WEE1 kinases for treatment of cancer in a human subject. Synergistic effects of combination compositions and treatments including administration of an AKT inhibitor and a WEE1 inhibitor are unexpectedly found as described herein. |
| FILED | Wednesday, November 22, 2023 |
| APPL NO | 18/517746 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082282 | D'ONOFRIO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHEASTERN UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony D'ONOFRIO (Northborough, Massachusetts); Kim LEWIS (Newton, Massachusetts) |
| ABSTRACT | This disclosure provides compounds and compositions useful for treating spirochete diseases such as Lyme disease as well as baits containing the compounds. |
| FILED | Wednesday, September 01, 2021 |
| APPL NO | 18/042741 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082288 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James M. Wilson (Philadelphia, Pennsylvania); Christie L. Bell (Boston, Massachusetts); Luc H. Vandenberghe (Cambridge, Massachusetts) |
| ABSTRACT | A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (AAV) viral vector having a capsid containing an AAV9 cell surface binding domain is described. The method involves modifying a clade F cell surface receptor which comprises a glycan having a terminal sialic acid residue and a penultimate β-galactose residue. The modification may involve retargeting the vector by temporarily functionally ablate AAV9 binding in a subset of cells, thereby redirecting the vector to another subset of cells. Alternatively, the modification may involve increasing cellular update efficiency by treating the cells with a neuraminidase to expose cell surface β-galactose. Also provided are compositions containing the AAV9 vector and a neuraminidase. Also provided is a method for purifying AAV9 using β-galactose linked to solid support. Also provided are mutant vectors which have been modified to alter their targeting specificity, including mutant AAV9 in which the galactose binding domain is mutated and AAV in which an AAV9 galactose binding domain is engineered. |
| FILED | Tuesday, August 15, 2023 |
| APPL NO | 18/450130 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/685 (20130101) A61K 31/7088 (20130101) Original (OR) Class A61K 38/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14043 (20130101) C12N 2750/14045 (20130101) C12N 2810/6027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082307 | BOT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kite Pharma, Inc. (Santa Monica, California); USA, as represented by the Sec, Dept. of HHS (Rockville, Maryland) |
| ASSIGNEE(S) | Kite Pharma, Inc. (Santa Monica, California); Ofc of Tech Transfer, NIH (Rockville, Maryland) |
| INVENTOR(S) | Adrian BOT (Santa Monica, California); Jeffrey S. WIEZOREK (Santa Monica, California); William GO (Santa Monica, California); Rajul JAIN (Santa Monica, California); James N. KOCHENDERFER (Santa Monica, California); Steven A. ROSENBERG (Bethesda, Maryland) |
| ABSTRACT | The invention provides methods of increasing the efficacy of a T cell therapy in a patient in need thereof. The invention includes methods of identifying a patient who would respond well to a T cell therapy or conditioning a patient prior to a T cell therapy so that the patient responds well to a T cell therapy. The conditioning involves administering one or more preconditioning agents prior to a T cell therapy and identifying biomarker cytokines prior to administering a T cell therapy. |
| FILED | Thursday, August 24, 2023 |
| APPL NO | 18/455033 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/095 (20130101) A61K 31/445 (20130101) A61K 31/665 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/00 (20130101) C07K 14/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/00 (20130101) C12N 15/85 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6869 (20130101) G01N 2333/5418 (20130101) G01N 2333/5443 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082313 | Yokota |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroki Yokota (Bloomington, Indiana) |
| ABSTRACT | A pharmaceutical composition includes a cell-free conditioned medium (CM) or extract or concentrate thereof obtained from a mammalian cell culture medium comprising a cultured substantially homogenous cancerous mammalian cell population. At least a portion of the cancerous mammalian cell population is contacted by at least one small molecule cell growth signaling pathway activator before being cultured in the cell culture medium. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 18/262799 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/32 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 2500/90 (20130101) C12N 2501/415 (20130101) C12N 2501/603 (20130101) C12N 2501/606 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082315 | RUVKUN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Gary RUVKUN (Newton, Massachusetts); J. Amaranath Govindan (Somerville, Massachusetts); Elamparithi Jayamani (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions comprising a bacterium or a metabolite thereof for enhancing mitochondrial and/or peroxisomal function. |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/351198 |
| CURRENT CPC | Fodder A23K 10/18 (20160501) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 2/52 (20130101) A23L 33/135 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/0056 (20130101) A61K 35/74 (20130101) Original (OR) Class Peptides C07K 14/195 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/0006 (20130101) C12N 9/0055 (20130101) C12N 9/0057 (20130101) C12N 2500/14 (20130101) C12N 2500/16 (20130101) C12N 2500/34 (20130101) Enzymes C12Y 101/99 (20130101) C12Y 110/0301 (20130101) C12Y 110/02002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082352 | CHEN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| INVENTOR(S) | Gong CHEN (Guangzhou, China PRC) |
| ABSTRACT | Methods of treating the effects of disruption of normal blood flow in the CNS in an individual subject in need thereof are provided according to aspects of the present invention which include administering a therapeutically effective dose of exogenous NeuroD1 to an area where normal blood flow has been disrupted. Compositions are provided including 1) a recombinant adeno-associated adenovirus expression vector comprising a glial cell specific promoter operably linked to a nucleic acid encoding a site-specific recombinase and 2) a recombinant adeno-associated adenovirus expression vector comprising a ubiquitous promoter operably linked to a nucleic acid encoding NeuroD1, wherein the nucleic acid encoding NeuroD1 is inverted and flanked by two sets of site-specific recombinase recognition sites such that action of the recombinase irreversibly inverts the nucleic acid encoding NeuroD1 such that NeuroD1 is expressed in a mammalian cell. |
| FILED | Friday, August 11, 2023 |
| APPL NO | 18/448421 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082361 | STOFFERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (PHILADELPHIA, Pennsylvania); The Children's Hospital of Philadelphia (PHILADELPHIA, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (PHILADELPHIA, Pennsylvania); The Children's Hospital of Philadelphia (PHILADELPHIA, Pennsylvania) |
| INVENTOR(S) | Doris STOFFERS (Moorestown, New Jersey); Diva D. DE LEON (Penn Valley, Pennsylvania); Charles STANLEY (Drexel Hill, Pennsylvania) |
| ABSTRACT | This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof. |
| FILED | Tuesday, February 14, 2023 |
| APPL NO | 18/168570 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082369 | Dong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Min Dong (Weatogue, Connecticut); Pyung-Gang Lee (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are modified Clostridial Botulinum neurotoxin (BoNT) polypeptides with a modified receptor binding domain of Clostridial Botulinum serotype A1 or A2. Modifications include substitution amino acid mutations. Isolated modified receptor binding domains, chimeric molecules, pharmaceutical compositions, and methods of using the same are also disclosed. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 18/268477 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/66 (20130101) A61K 38/4893 (20130101) Original (OR) Class Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Enzymes C12Y 304/24069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082371 | Shea et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lonnie D Shea (Ann Arbor, Michigan); Stephen Miller (Evanston, Illinois); Derrick McCarthy (Evanston, Illinois); Jonathan Woon Teck Yap (Evanston, Illinois) |
| ABSTRACT | The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance). |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 9/1271 (20130101) A61K 9/1647 (20130101) A61K 39/001 (20130101) A61K 39/0005 (20130101) Original (OR) Class A61K 39/0008 (20130101) A61K 39/35 (20130101) A61K 39/39 (20130101) A61K 39/385 (20130101) A61K 47/6937 (20170801) A61K 2039/577 (20130101) A61K 2039/6093 (20130101) A61K 2039/55555 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082373 | IRVINE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell J. IRVINE (Arlington, Massachusetts); Leyuan Ma (Brookline, Massachusetts) |
| ABSTRACT | The disclosure features amphiphilic ligand conjugates comprising a chimeric antigen receptor (CAR)ligand and a lipid. The disclosure also features compositions and methods of using the same, for example, to stimulate proliferation of CAR expressing cells. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/339230 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0029 (20130101) A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 47/543 (20170801) Peptides C07K 14/4748 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082378 | Muthukrishnan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gowrishankar Muthukrishnan (Rochester, New York); Steven R. Gill (Webster, New York); Cal D. Palumbo (Rochester, New York); Edward M. Schwarz (Rochester, New York) |
| ABSTRACT | The present disclosure generally relates to compositions and methods for inducing an immune response against S. aureus antigens in a subject. The invention also relates to nucleic acid vaccines and methods of use thereof to treat or prevent diseases or disorders associated with S. aureus infection. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 18/261568 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/085 (20130101) Original (OR) Class A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/80 (20130101) C12N 9/2402 (20130101) C12N 9/2462 (20130101) Enzymes C12Y 302/01017 (20130101) C12Y 302/01096 (20130101) C12Y 305/01028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082381 | Vajdy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EpitoGenesis, Inc. (Sacramento, California) |
| ASSIGNEE(S) | EpitoGenesis, Inc. (Sacramento, California) |
| INVENTOR(S) | Michael Vajdy (Sacramento, California); Shohre Golestani (Sacramento, California) |
| ABSTRACT | The present invention provides adjuvant compositions that are capable of modulating the immune response in a subject, including enhancing or suppressing the immune response. These adjuvant compositions may also be used to enhance or suppress the immunogenicity of antigens by enhancing or suppressing antigen-presentation activity, enhancing or suppressing innate immune responses through activation or suppression of, e.g., natural killer cells, and/or direct activation of subsets of B and/or T cells. Also provided are methods of making the adjuvant compositions as well as methods of using the adjuvant compositions. In certain embodiments, the compositions comprise combinations of the following: a pharmaceutically acceptable carrier, a flavonoid, a tannin and a vitamin. The pharmaceutically acceptable carrier may be selected from mustard oil, corn oil, olive oil, grape seed oil, oleic acid and squalene; the flavonoid may be a catechin, such as EGCG and CH; the tannin may be gallic acid; and the vitamin may be selected from Vitamin A, Vitamin E and Vitamin D. The compositions may further comprise an antigen. |
| FILED | Monday, April 03, 2023 |
| APPL NO | 18/130108 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/55505 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082384 | Compans et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Compans (Atlanta, Georgia); Elena Vassilieva (Roswell, Georgia) |
| ABSTRACT | This disclosure relates to boosting the immunogenicity of vaccines using an adjuvant combination comprising a saponin and an agonist of the intracellular stimulator of interferon genes pathway. In certain embodiments, the vaccine comprises an inactivated virus, attenuated virus, virus protein, virus like particle, or virosome. In certain embodiments, the human subject is of advanced age or elderly. In certain embodiments, the viral vaccine is an influenza vaccine. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511859 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082386 | Morrison |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trudy G. Morrison (Northborough, Massachusetts) |
| ABSTRACT | The invention provides methods for using virus-like particle (VLP) vaccines containing a stabilized pre-fusion respiratory syncytial virus (RSV) F protein to stimulate RSV neutralizing antibodies in pre-immune subjects. In one embodiment, the invention provides a method for immunizing a mammalian subject in need of immunizing against Respiratory Syncytial virus (RSV) infection, comprising, a) providing i) a pre-immune mammalian subject containing RSV neutralizing antibodies, ii) a first composition comprising recombinant chimeric Newcastle disease virus-like particles (ND VLPs), that contain a chimeric protein comprising, in operable combination, 1) stabilized pre-fusion RSV F protein ectodomain, 2) transmembrane (TM) domain of NDV F protein, and 3) cytoplasmic (CT) domain of NDV F protein, and b) administering an immunologically effective amount of the first composition to the pre-immune subject to produce an immunized subject that comprises an increase in the level of the RSV neutralizing antibodies compared to the level of RSV neutralizing antibodies in the pre-immune subject. In one embodiment, the level of the RSV neutralizing antibodies in the pre-immune subject does not prevent RSV infection of the pre-immune subject. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/17 (20130101) Original (OR) Class A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082393 | Pulendran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bali Pulendran (Redwood City, California); Florian Wimmers (Palo Alto, California) |
| ABSTRACT | Methods are provided herein for modulating the epigenome of immune cells by administration of an immunostimulatory composition comprising adjuvants, e.g. vaccine adjuvants, to stimulate broad and persistent innate immunity against pathogens unrelated to antigens present in the composition. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 18/270996 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 2039/55505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082403 | Yang, Ph.D. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Otto O. Yang, Ph.D. (Los Angeles, California); Ayub Ali (Porter Ranch, California); Don J. Diamond (Glendora, California); Flavia Chiuppesi (Monrovia, California); Felix Wussow (Monrovia, California) |
| ABSTRACT | Disclosed herein are CMV-specific CARs. In some embodiments. the present invention is directed to a method of treating, reducing, or inhibiting an infection by a cytomegalovirus in a subject, which comprises administering to the subject (a) an expression vector that encodes a CMV-specific CAR as described herein, or (b) one or more cells that are transduced with the expression vector. |
| FILED | Monday, October 12, 2020 |
| APPL NO | 17/766989 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4631 (20230501) A61K 39/464838 (20230501) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/089 (20230801) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082405 | Kluge et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan A. Kluge (Southborough, Massachusetts); Fiorenzo G. Omenetto (Lexington, Massachusetts); David L. Kaplan (Concord, Massachusetts) |
| ABSTRACT | The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions. In some embodiments, the disclosure provides silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, the disclosure provides low molecular weight silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, an active agent is stabilized in a silk composition, e.g., for a period of time and/or against certain conditions or events. In some embodiments, a component present in a silk fibroin composition may be subject to analysis and/or characterization. In some embodiments, a component present in a silk fibroin composition may be recovered from the composition. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/829271 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/19 (20130101) A61K 38/1825 (20130101) A61K 47/42 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3604 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/24 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Peptides C07K 14/503 (20130101) C07K 14/43518 (20130101) C07K 14/43586 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082420 | Lu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Quan Lu (Cambridge, Massachusetts) |
| ABSTRACT | Methods, systems, compositions and strategies for the delivery of RNA into cells in vivo, ex vivo, or in vitro via ARMMs are provided. In some aspects, ARMMs containing fusion proteins of ARRDC1 fused to an RNA binding protein or an RNA binding protein fused to a WW domain are provided. In some aspects, ARMMs containing binding RNAs associated with cargo RNAs are provided. In other aspects, cargo RNAs associated with a binding RNA, such as a TAR element, are loaded into ARMMs via ARRDC1 fusion proteins containing an RNA binding protein, such as trans-activator of transcription (Tat) protein. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/343685 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5068 (20130101) A61K 47/54 (20170801) A61K 47/62 (20170801) A61K 47/6901 (20170801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) C12N 2740/16322 (20130101) C12N 2795/10222 (20130101) C12N 2795/10322 (20130101) C12N 2795/18122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082459 | Hasturk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tuffs College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Onur Hasturk (Medford, Massachusetts); Jaewon Choi (Medford, Massachusetts); David L. Kaplan (Concord, Massachusetts) |
| ABSTRACT | Tyramine-substituted silk fibroin compositions as well as methods for making and using the same are provided. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 17/768876 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/227 (20130101) Original (OR) Class A61L 27/3604 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082534 | DICARLO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | James DICARLO (Cambridge, Massachusetts); Pouya BASHIVAN (Cambridge, Massachusetts); Kohitij KAR (Arlington, Massachusetts) |
| ABSTRACT | Techniques for non-invasively controlling targeted neural activity of a subject are provided herein. The techniques include applying a stimulus input to the subject, the stimulus input being formed by a deep artificial neural network (ANN) model and being configured to elicit targeted neural activity within a brain of the subject. The stimulus input may be a pattern of luminous power generated by the deep ANN model and applied to retinae of the subject. The stimulus input may be generated by the deep ANN model based on a mapping of the subject's neural responses to neurons of the deep ANN model. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482806 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) A61B 5/378 (20210101) A61B 5/388 (20210101) A61B 5/7264 (20130101) A61B 2562/028 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 21/00 (20130101) Original (OR) Class A61M 2021/005 (20130101) A61M 2230/10 (20130101) A61M 2250/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082571 | Vrabec et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tina L. Vrabec (Cleveland, Ohio); Kevin L. Kilgore (Cleveland, Ohio); Niloy Bhadra (Cleveland, Ohio); Laura Shaw (Cleveland, Ohio); David Roberts (Cleveland, Ohio); Narendra Bhadra (Cleveland, Ohio) |
| ABSTRACT | Systems and methods that deliver a continuous partial nerve conduction block are described. A waveform generator can configure one or more direct current (DC) waveforms to provide a continuous partial nerve conduction block. One or more electrodes can deliver the one or more DC waveforms to provide the partial block to the neural structure. Feedback can be provided to the waveform generator related to the partial block. The feedback includes monitoring a property associated with the partial block and altering a parameter associated with the one or more direct current waveforms in response to the property associated with the partial block. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/514470 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/20 (20130101) A61N 1/0551 (20130101) Original (OR) Class A61N 1/36067 (20130101) A61N 1/36103 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083839 | John et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Varghese John (Los Angeles, California); Jesus Campagna (Playa Del Rey, California); Michael E. Jung (Los Angeles, California); Barbara Jagodzinska (Redwood City, California) |
| ABSTRACT | The present disclosure relates to compounds that are capable of inhibiting PRMT8 and/or upregulating SirT1. The disclosure further relates to methods of treating neurodegenerative diseases and disorders (e.g., Alzheimer's disease). |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 18/030686 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/07 (20130101) Acyclic or Carbocyclic Compounds C07C 229/08 (20130101) Original (OR) Class C07C 237/04 (20130101) C07C 237/06 (20130101) C07C 237/20 (20130101) C07C 2601/04 (20170501) C07C 2601/08 (20170501) C07C 2601/14 (20170501) C07C 2602/08 (20170501) C07C 2602/10 (20170501) Heterocyclic Compounds C07D 207/12 (20130101) C07D 207/16 (20130101) C07D 209/48 (20130101) C07D 211/50 (20130101) C07D 211/60 (20130101) C07D 213/30 (20130101) C07D 213/40 (20130101) C07D 223/12 (20130101) C07D 223/16 (20130101) C07D 233/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083859 | Spiegel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); David CAIANIELLO (New Haven, Connecticut) |
| ABSTRACT | The present invention is directed to bi-functional compounds which find use as pharmaceutical agents in the treatment of disease states and/or conditions which are mediated through macrophage migration inhibitory factor (MIF) or immunoglubin G (IgG). The present invention is also directed to pharmaceutical compositions which comprise these bi-functional compounds as well as methods for treating disease states and/or conditions which are mediated through MIF/IgG or where MIF/IgG is a contributing factor to the development and perpetuation of diseases and/or conditions, especially including autoimmune diseases and cancer, among others. The purpose of the present invention is to provide a molecular strategy to lower plasma MIF/IgG level in patients with autoimmune diseases or certain types of cancers. The bi-functional molecule construct is comprised of a MIF/IgG-targeting motif, that is derived from small molecule MIF/IgG ligands, and an ASGPr-targeting motif that binds to hepatocyte asialoglycoprotein receptor (ASGPr). The compounds selectively bind MIF or IgG in plasma and subsequently engage the endo-lysosomal pathway of hepatocytes through ASGPr. As a consequence, MIF/IgG is internalized and degraded by hepatocytes, thus resulting in potential attenuation of corresponding disease symptoms which are modulated through MIF/IgG. |
| FILED | Tuesday, August 08, 2023 |
| APPL NO | 18/446296 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 249/04 (20130101) Original (OR) Class C07D 413/14 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083868 | WHITEHEAD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher E. WHITEHEAD (Ann Arbor, Michigan); Judith S. LEOPOLD (Ann Arbor, Michigan) |
| ABSTRACT | This disclosure is in the field of medicinal chemistry, and relates to a new class of small-molecules having the Formula I, or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof, wherein the variables Ring A, X, R1a, R1b, R2, R3, R4, m, n, and p are described herein, which function as dual inhibitors of EGFR proteins and PI3K proteins. The disclosure further relates to the use of the compounds described herein as therapeutics for the treatment of diseases and conditions mediated by EGFR proteins and/or PI3K proteins, such as cancer and other diseases. |
| FILED | Wednesday, April 26, 2023 |
| APPL NO | 18/307576 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/04 (20130101) Original (OR) Class C07D 401/10 (20130101) C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 413/04 (20130101) C07D 413/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083877 | Watts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Val J. Watts (West Lafayette, Indiana); Richard M. van Rijn (Fremont, California); Daniel Patrick Flaherty (West Lafayette, Indiana); Jatinder Kaur (Edmonton, Canada) |
| ABSTRACT | The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein. |
| FILED | Wednesday, April 26, 2023 |
| APPL NO | 18/139916 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/32 (20180101) A61P 25/36 (20180101) Heterocyclic Compounds C07D 403/04 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 409/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083885 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Wang (Tucson, Arizona); Naoya Kitamura (Tucson, Arizona); Chunlong Ma (Tucson, Arizona) |
| ABSTRACT | This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a methyl-acetamido-propanamide structure (e.g., Formula I) which function as inhibitors of the SARS-CoV-2 main protease (Mpro), which function as therapeutics for the treatment of viral infection characterized with Mpro protease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with Mpro protease activity and/or expression. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 18/265335 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) A61K 31/706 (20130101) A61K 31/4706 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 401/12 (20130101) C07D 405/12 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083894 | LU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tao LU (Carmel, Indiana); Lakshmi Milind PRABHU (Indianapolis, Indiana) |
| ABSTRACT | Provided are compounds of formulas (I), (II), (III), and (IV), which effectively inhibit protein arginine methyltransferase 5 (PRMT5). Also provided are methods of using the compounds, including a method of treating cancer, a method of inhibiting the activity of PRMT5 in a cell, and a method of treating a disease associated with increased activity of PRMT5. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500786 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 43/23 (20130101) Heterocyclic Compounds C07D 413/14 (20130101) C07D 453/02 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 498/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083905 | Cook et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin); Centre for Addiction and Mental Health (Toronto, Canada); University of Belgrade - Faculty of Pharmacy (Belgrade, Serbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James M. Cook (Milwaukee, Wisconsin); Guanguan Li (Milwaukee, Wisconsin); Michael Ming-Jin Poe (Kalamazoo, Michigan); Miroslav M. Savic (Belgrade, Serbia); Etienne Sibille (Toronto, Canada) |
| ABSTRACT | Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them. |
| FILED | Wednesday, August 02, 2023 |
| APPL NO | 18/363933 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/22 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083932 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | YIMING WANG (PITTSBURGH, Pennsylvania); YIDONG WANG (YANGZHOU, China PRC); RUIHAN WANG (PITTSBURGH, Pennsylvania) |
| ABSTRACT | The invention includes a cationic cyclopentadienyliron dicarbonyl complex according to the general structure (I): wherein, Y is (CH2)n or (CH2)mA(CH2)n, A is O, NSO2R, S, or CR1R2, each of R, R1 and R2 with respect to A is independently alkyl or aryl, n is an integer from 1 to 8, m+n is an integer from 2 to 7, Z is alkyl, aryl, heteroaryl, or CF3, and X is BF4−, ClO4−, PF6−, AsF6−, or SbF6−. |
| FILED | Friday, August 11, 2023 |
| APPL NO | 18/232866 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083949 | Xue et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min Xue (Chino Hills, California); Siwen Wang (Jurupa Valley, California); Nathan Guevara (Pomona, California) |
| ABSTRACT | Certain embodiments of the invention provide cell penetrating peptides. Certain embodiments of the invention provide methods and compositions for intracellular delivery. Certain embodiments of the invention provide methods and compositions for targeted delivery. |
| FILED | Monday, August 14, 2023 |
| APPL NO | 18/233684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) Peptides C07K 7/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083951 | PAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Hui-lin PAN (Houston, Texas) |
| ABSTRACT | The present disclosure provides α2δ-1 C-terminal domain mimetics for the treatment of pain, epilepsy or other disorders in a subject. Further provided is an α2δ-1 C-terminal domain peptide which blocks binding of α2δ-1 to the glutamate receptors NMDAR and AMPAR. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/465145 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/485 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 23/00 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/00 (20130101) Original (OR) Class C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/1138 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083952 | Chilkoti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh Chilkoti (Durham, North Carolina); Stefan Roberts (Raleigh, North Carolina) |
| ABSTRACT | Disclosed herein are partially ordered polypeptides, which include a plurality of disordered domains and a plurality of structured domains. The partially ordered polypeptides may have phase transition behavior and form aggregates at, above, or below certain temperatures. Further provided are cellular scaffolds comprised of the partially ordered polypeptides. |
| FILED | Wednesday, April 19, 2023 |
| APPL NO | 18/303530 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/5169 (20130101) A61K 35/12 (20130101) A61K 35/74 (20130101) Peptides C07K 14/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083953 | LIEBER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andre LIEBER (Seattle, Washington); Hongjie WANG (Seattle, Washington) |
| ABSTRACT | Disclosed are recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/475950 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/42 (20130101) Peptides C07K 7/06 (20130101) C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0652 (20130101) C12N 7/00 (20130101) C12N 15/10 (20130101) C12N 15/86 (20130101) C12N 2710/10321 (20130101) C12N 2710/10322 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083954 | Kong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leopold Kong (Bethesda, Maryland); Ian A. Wilson (La Jolla, California); Natalia de Val (San Diego, California); Andrew B. Ward (San Diego, California); Dennis Burton (La Jolla, California); Linling He (San Diego, California); Jiang Zhu (San Diego, California) |
| ABSTRACT | The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections. |
| FILED | Tuesday, August 15, 2023 |
| APPL NO | 18/449739 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 47/6929 (20170801) Peptides C07K 14/005 (20130101) C07K 14/162 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083956 | Adams et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); WASHINGTON UNIVERSITY (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John H. Adams (Tampa, Florida); Christopher L. King (Moreland Hills, Ohio); Niraj H. Tolia (St. Louis, Missouri); Edwin Chen (St. Louis, Missouri); Nichole Diane Salinas (St. Louis, Missouri); Miriam Thankam George (Nilgris, India); Francis B. Ntumngia (Tampa, Florida); Samantha Jones Barnes (Tampa, Florida) |
| ABSTRACT | Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470301 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) A61K 2039/575 (20130101) Peptides C07K 14/001 (20130101) C07K 14/445 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083966 | Russell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Stephen James Russell (Rochester, Minnesota); Shruthi Naik (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding VSV polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/120798 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/766 (20130101) A61K 38/215 (20130101) A61K 48/005 (20130101) Peptides C07K 14/565 (20130101) C07K 14/705 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/20232 (20130101) C12N 2760/20243 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083979 | Gladwin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Mark T. Gladwin (Baltimore, Maryland); Jesus Tejero Bravo (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity. The monomeric mutant globins are infused into blood, where they rapidly and irreversibly sequester carbon monoxide, and thus limit toxic effects of carbon monoxide on cellular respiration and oxygen transport and utilization. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/00 (20130101) A61K 38/41 (20130101) Peptides C07K 14/795 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083983 | BAUM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regeneron Pharmaceuticals, Inc. (Tarrytown, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alina BAUM (Pleasantville, New York); Christos KYRATSOUS (Irvington, New York) |
| ABSTRACT | Provided herein are monoclonal antibodies, or antigen-binding fragments thereof, that bind to the influenza B hemagglutinin (HA) protein, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies are useful for inhibiting or neutralizing influenza B virus activity, thus providing a means of treating or preventing influenza infection in humans. Also provided is the use of one or more antibodies that bind to the influenza B HA for preventing viral attachment and/or entry into host cells. The antibodies may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/453207 |
| CURRENT CPC | Peptides C07K 16/1018 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083985 | Han |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yiping Han (Paramus, New Jersey) |
| ABSTRACT | Anti-Fn amyloid-like FadA antibodies and compositions are provided and methods of treating cancers, including pancreatic and colorectal, and periodontal diseases. Methods include preventing, reducing development, or treating disease in a subject in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent which inhibits or blocks an amyloid-like FadA secreted from Fusobacterium nucleatum (Fn). |
| FILED | Monday, August 28, 2023 |
| APPL NO | 18/457239 |
| CURRENT CPC | Peptides C07K 16/1203 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083987 | Rosenthal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Annexon, Inc. (Brisbane, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arnon Rosenthal (Woodside, California); Michael Leviten (Emerald Hills, California) |
| ABSTRACT | The present invention provides anti-C1q antibodies and methods of using the same. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/110574 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0004 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/40 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56966 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083998 | ZENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CIY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Defu ZENG (Duarte, California); Qingxiao SONG (Duarte, California); Arthur D. RIGGS (Duarte, California) |
| ABSTRACT | Disclosed is a method of preventing or treating acute GVHD (aGVHD) such as gut aGVHD, steroid-resistant aGVHD, and steroid-resistant gut aGVHD in a subject receiving a hematopoietic cell transplantation (HCT) or autoimmune colitis by administering to the subject an effective amount of an anti-IL-22 antibody, an anti-IL-6 antibody, donor-type CX3CR1hi MNPs, donor-type NK cells, a ceacam-1 antagonist, an anti-Gr-1 antibody, or a combination thereof. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 18/270706 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 35/17 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 37/06 (20180101) Peptides C07K 16/40 (20130101) C07K 16/248 (20130101) Original (OR) Class C07K 16/3007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084007 | Orentas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Rimas J. Orentas (Washington, District of Columbia); Ira H. Pastan (Chevy Chase, Maryland); Dimiter S. Dimitrov (Frederick, Maryland); Crystal L. MacKall (Stanford, California) |
| ABSTRACT | The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/502993 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 16/3061 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) C12N 15/85 (20130101) C12N 2501/505 (20130101) C12N 2501/599 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084008 | Orentas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Rimas J. Orentas (Washington, District of Columbia); Ira H. Pastan (Chevy Chase, Maryland); Dimiter S. Dimitrov (Frederick, Maryland); Crystal L. MacKall (Stanford, California) |
| ABSTRACT | The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/503107 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 16/3061 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) C12N 15/85 (20130101) C12N 2501/505 (20130101) C12N 2501/599 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084030 | PANCE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katarina PANCE (San Francisco, California); James A. WELLS (San Francisco, California) |
| ABSTRACT | The present disclosure relates to targeted degradation platform technology. For example, the present disclosure relates to bispecific binding agents for degrading endogenous proteins, whether membrane-associated or soluble, using the lysosome pathway. The disclosure also provides methods useful for producing such agents, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various disorders. |
| FILED | Wednesday, July 26, 2023 |
| APPL NO | 18/359562 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2803 (20130101) C07K 16/2896 (20130101) Original (OR) Class C07K 2317/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084034 | MARIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania); THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY (Rockville, Maryland) |
| ASSIGNEE(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania); THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY (Bethesda, Maryland) |
| INVENTOR(S) | John M. MARIS (Phildelphia, Pennsylvania); Kristopher R. BOSSE (Philadelphia, Pennsylvania); Dimiter DIMITROV (Frederick, Maryland); Zhongyu ZHU (Frederick, Maryland); Dontcho V. JELEV (Rockville, Maryland) |
| ABSTRACT | The present disclosure is directed to antibodies binding to Glypican 2 and methods of using such antibodies to treat cancers that express or overexpress the Glypican 2 antigen. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/499054 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 47/6889 (20170801) A61K 47/6929 (20170801) A61K 2039/572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/18 (20130101) C07K 16/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084044 | Still et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | George Mason University (Fairfax, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amanda Haymond Still (Manassas, Virginia); Remi Veneziano (McLean, Virginia); Jessica A. Roman (Fairfax, Virginia); Lance Liotta (Bethesda, Maryland); Alessandra Luchini Kunkel (Burke, Virginia) |
| ABSTRACT | The present disclosure relates to heteromultivalent nucleic acid scaffolds and peptides, and to compositions comprising the scaffolds and peptides, and to methods for preparing and using the scaffolds and peptides. The present disclosure also relates to use of the scaffolds, peptides, and compositions for preventing or disrupting interactions between molecules, in particular protein-protein interactions, in particular for the treatment or prevention of disease, in particular cancer, such as breast cancer. |
| FILED | Tuesday, September 05, 2023 |
| APPL NO | 18/461041 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/54 (20130101) C07K 14/545 (20130101) C07K 19/00 (20130101) Original (OR) Class C07K 2318/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 2310/18 (20130101) C12N 2310/315 (20130101) C12N 2310/3513 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084163 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elise Lin Cheng (iowa City, Iowa); C. Allan Guymon (Iowa City, Iowa); Marlan R. Hansen (Solon, Iowa); Braden Leigh (Iowa City, Iowa) |
| ABSTRACT | Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507969 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/34 (20130101) A61L 29/041 (20130101) A61L 29/085 (20130101) A61L 31/10 (20130101) A61L 31/048 (20130101) A61L 2300/404 (20130101) A61L 2420/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/11 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1675 (20130101) C09D 133/10 (20130101) Original (OR) Class C09D 133/26 (20130101) C09D 151/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084235 | Fernandez-Alcon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose Fernandez-Alcon (Cambridge, Massachusetts); Norman Wen (Newton, Massachusetts); Richard Novak (Jamaica Plain, Massachusetts); Donald E. Ingber (Boston, Massachusetts); Geraldine A. Hamilton (Cambridge, Massachusetts); Christopher Hinojosa (Cambridge, Massachusetts); Karel Domansky (Charlestown, Massachusetts); Daniel Levner (Cambridge, Massachusetts); Guy Thompson, II (Lexington, Massachusetts); Kambez Hajipouran Benam (Cambridge, Massachusetts); Remi Villenave (Boston, Massachusetts); Thomas Umundum (Salzburg, Austria); Alfred Paris (Salzburg, Austria); Georg Bauer (Salzburg, Austria) |
| ABSTRACT | An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470404 |
| CURRENT CPC | Separation B01D 61/18 (20130101) B01D 63/081 (20130101) B01D 67/0023 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502753 (20130101) B01L 2200/12 (20130101) B01L 2200/0647 (20130101) B01L 2300/0645 (20130101) B01L 2300/0887 (20130101) B01L 2400/0487 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/26 (20130101) C12M 25/02 (20130101) C12M 35/04 (20130101) C12M 41/00 (20130101) C12M 41/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084257 | Slukvin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor Slukvin (Madison, Wisconsin); Ho Sun Jung (Madison, Wisconsin) |
| ABSTRACT | This disclosure provides reagents and methods for producing NK progenitor cells, NK cells, megakaryocytes and CAR derivatives thereof from hematopoietic stem cells. Pharmaceutical compositions comprising NK progenitor cells produced by the reagents and methods of the invention and immunotherapeutic methods using these pharmaceutical compositions are also provided. |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/463211 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/19 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0644 (20130101) C12N 5/0646 (20130101) Original (OR) Class C12N 2501/60 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084267 | HEATON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas HEATON (Durham, North Carolina); Heather FROGGATT (Durham, North Carolina); Kaitlyn BURKE (Durham, North Carolina); Benjamin CHAMBERS (Durham, North Carolina); Rebecca LEONARD (Durham, North Carolina); Ryan CHAPARIAN (Durham, North Carolina) |
| ABSTRACT | The present invention provides recombinant viral segments comprising an artificial intron, DNA constructs encoding these viral segments, and recombinant viruses comprising these viral segments. Also provided are methods of making and using the recombinant viruses described herein. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 18/271983 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2760/16121 (20130101) C12N 2760/16122 (20130101) C12N 2760/16143 (20130101) C12N 2760/16171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084269 | Whitehead et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the USA as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The Government of the USA as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Stephen S. Whitehead (Bethesda, Maryland); Joseph E. Blaney (Gettysburg, Pennsylvania); Brian R. Murphy (Bethesda, Maryland); Ching-Juh Lai (Bethesda, Maryland) |
| ABSTRACT | The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/355265 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) C07K 14/1825 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 7/045 (20130101) Original (OR) Class C12N 2770/24162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084286 | Adalsteinsson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Viktor A. Adalsteinsson (Cambridge, Massachusetts); Shervin Tabrizi (Cambridge, Massachusetts); Sangeeta N. Bhatia (Cambridge, Massachusetts); J. Christopher Love (Cambridge, Massachusetts); Maria Carmen Martin Alonso (Cambridge, Massachusetts); Kan Xiong (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides a method for substantially increasing the concentration of cfDNA in a patient. By injecting a patient with lipid and/or polymer nanoparticles, agents that bind cfDNA, or inhibit deoxyribonucleases prior to collection of a sample of cfDNA, e.g., by way of a liquid biopsy, major pathways for the degradation of cfDNA are temporarily blocked, permitting transient accumulation of cfDNA. This strategy has the potential to dramatically enhance the quality of detection achieved by downstream cfDNA e analytical applications, such as sequencing applications. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 18/273922 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 38/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084287 | Blainey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Blainey (Cambridge, Massachusetts); Navpreet Ranu (Cambridge, Massachusetts); Todd Gierahn (Cambridge, Massachusetts); J. Christopher Love (Cambridge, Massachusetts) |
| ABSTRACT | The present invention relates to the analysis of complex single cell sequencing libraries. Disclosed are methods for enrichment of library members based on the presence of cell-of origin barcodes to identify and concentrate DNA that is relevant to interesting cells or components that would be expensive or difficult to study otherwise. Also, disclosed are methods of capturing cDNA library molecules by use of CRISPR systems, hybridization or PCR. The present invention allows for identifying the properties of rare cells in single cell RNA-seq data and accurately profile them through clustering approaches. Further information on transcript abundances from subpopulations of single cells can be analyzed at a lower sequencing effort. The methods also allow for linking TCR alpha and beta chains at the single cell level. |
| FILED | Thursday, June 01, 2023 |
| APPL NO | 18/327345 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 15/1006 (20130101) Original (OR) Class C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/465 (20210501) Enzymes C12Y 301/11 (20130101) C12Y 302/02027 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) C40B 40/06 (20130101) C40B 40/10 (20130101) C40B 50/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084297 | KHVOROVA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastasia KHVOROVA (Westborough, Massachusetts); Mehran NIKAN (Boston, Massachusetts); Matthew HASSLER (Worcester, Massachusetts); Maire OSBORN (Worcester, Massachusetts); Reka HARASZTI (Shrewsbury, Massachusetts); Andrew COLES (Auburn, Massachusetts); Anton TURANOV (Boston, Massachusetts); Neil ARONIN (Newtonville, Massachusetts); Annabelle BISCANS (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/170167 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/7088 (20130101) A61K 47/54 (20170801) A61K 47/543 (20170801) A61K 47/549 (20170801) A61K 47/551 (20170801) A61K 47/554 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 1/16 (20180101) A61P 5/00 (20180101) A61P 9/00 (20180101) A61P 11/00 (20180101) A61P 13/12 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) C07H 21/02 (20130101) C07H 21/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/312 (20130101) C12N 2310/315 (20130101) C12N 2310/346 (20130101) C12N 2310/351 (20130101) C12N 2310/3515 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084302 | Jin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hailing Jin (Riverside, California) |
| ABSTRACT | The disclosure provides RNAi strategies for targeting a fungal tetraspanin protein. |
| FILED | Monday, August 07, 2023 |
| APPL NO | 18/366303 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 15/8282 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084303 | Mueller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Christian Mueller (Worcester, Massachusetts); Neil Aronin (Worcester, Massachusetts); Edith L. Pfister (Worcester, Massachusetts) |
| ABSTRACT | Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (111 1) and methods of treating Huntington's disease using the same. |
| FILED | Thursday, August 17, 2023 |
| APPL NO | 18/451147 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/3519 (20130101) C12N 2330/51 (20130101) C12N 2750/14121 (20130101) C12N 2750/14141 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084324 | Mao et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hai-Quan Mao (Baltimore, Maryland); Yizong Hu (Baltimore, Maryland); Yining Zhu (Baltimore, Maryland) |
| ABSTRACT | Disclosed are the optimal composition and size of DNA/polycation particles for efficient transfection of viral production cells in both adherent and suspension cultures. The size-dependent feature of DNA/polycation particle-mediated transfection for particles between 50 nm and 1000 nm also is disclosed. A new scalable method based on kinetic control of DNA/polycation nanoparticle assembly to prepare shelf-stable particles with defined sizes between 50 nm and 1000 nm also is disclosed. The presently disclosed DNA/polycation particles yield superior and reproducible transfection activity and shelf stability and can be used as an off-the-shelf product. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/261944 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 25/25 (20220101) B01F 2215/045 (20130101) B01F 2215/0431 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2740/15022 (20130101) C12N 2740/15043 (20130101) C12N 2740/15052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084330 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Michael Segel (Cambridge, Massachusetts); Blake Lash (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions, systems, and methods for delivering cargo to a target cell. The compositions, systems, and methods comprise one or more polynucleotides encoding one or more LTR retroelement polypeptides for forming a delivery vesicle and one or more capture moieties for packaging a cargo within the delivery vesicle. The one or more LTR retroelement polypeptides for forming a delivery vesicle may comprise two or more of an LTR retroelement gag protein, a retroelement envelope protein, a an LTR retroelement reverse transcriptase, or a combination thereof. The LTR retroelement polypeptide alone, the LTR retroelement envelope protein alone, or both the LTR retroelement-derived polypeptide and LTR retroelement envelope protein may be endogenous. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 18/272158 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/88 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2740/16023 (20130101) C12N 2740/16043 (20130101) C12N 2740/16045 (20130101) C12N 2760/20222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084332 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts); Soumya Kannan (Cambridge, Massachusetts); Suchita Nety (Cambridge, Massachusetts) |
| ABSTRACT | Systems, methods and composition for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising novel TnpB polypeptides and a reprogrammable targeting nucleic acid component and methods and application of use are provided. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 18/271684 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/70 (20130101) C12N 15/74 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2800/80 (20130101) C12N 2800/101 (20130101) C12N 2800/107 (20130101) Enzymes C12Y 301/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084356 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| INVENTOR(S) | Yuhong Wang (Houston, Texas); Doris Xu (Houston, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of synthesizing a peptide by associating at least one isolated ribosomal RNA (rRNA) fragment with a plurality of transfer RNA fragments linked to amino acids (tRNA fragments). The at least one rRNA fragment includes at least one domain that associates with the tRNA fragments. The at least one rRNA fragment catalyzes the synthesis of the peptide through peptidyl transfer of the amino acids from the tRNA fragments independently of messenger RNA (mRNA) templates. Additionally, the peptidyl transfer occurs independently of proteins. Further embodiments of the present disclosure pertain to systems for synthesizing a peptide. Such systems include the rRNA fragments of the present disclosure and optionally a plurality of tRNA fragments. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 18/272535 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) C12N 9/104 (20130101) C12N 15/113 (20130101) C12N 2310/12 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 203/02012 (20130101) C12Y 601/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084360 | Ismagilov et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. Ismagilov (Altadena, California); Natalie Wu-Woods (Pasadena, California); Jacob T. Barlow (Cambridge, Massachusetts); Anna E. Romano (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems to selectively deplete a biological sample of host compartments and/or host nucleic acid while enriching the sample microbial compartments and/or related microbial nucleic acid. In addition, provided herein are compositions, methods and systems related to said host depletion and microbial enrichment methods and systems. |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/351461 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084364 | ZHANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng ZHANG (Cambridge, Massachusetts); Bernd ZETSCHE (Cambridge, Massachusetts); Jonathan S. GOOTENBERG (Cambridge, Massachusetts); Omar O. ABUDAYYEH (Cambridge, Massachusetts); Ian SLAYMAKER (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed. |
| FILED | Thursday, August 17, 2023 |
| APPL NO | 18/451315 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6832 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084372 | HASELTON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Frederick R. HASELTON (Nashville, Tennessee); David T. EVANS (Nashville, Tennessee); Megan E. PASK (Nashville, Tennessee); Emily C. KIGHT (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to methods of detecting small fragments of known nucleic acid biomarkers. |
| FILED | Thursday, August 03, 2023 |
| APPL NO | 18/364809 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084381 | Vogelstein et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Frankford, Delaware); Nickolas Papadopoulos (Towson, Maryland); Isaac A. Kinde (Beaumont, California) |
| ABSTRACT | The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ≥95% of them contain the identical mutation. We illustrate the utility of this approach for determining the fidelity of a polymerase, the accuracy of oligonucleotides synthesized in vitro, and the prevalence of mutations in the nuclear and mitochondrial genomes of normal cells. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507776 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2525/179 (20130101) C12Q 2525/191 (20130101) C12Q 2563/179 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084385 | Salk et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse Salk (Seattle, Washington); Lawrence A. Loeb (Bellevue, Washington); Michael Schmitt (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465952 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084386 | Darnell et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert B. Darnell (New York, New York); Dana Orange (New York, New York) |
| ABSTRACT | The present disclosure provides biological markers which are molecular and cellular antecedents of rheumatoid arthritis (RA) flares. The present disclosure provides RNA and protein markers that can predict an RA flare one or two weeks prior to the flare. The present disclosure further provides blood circulating cells, particularly pre-inflammatory mesenchymal cells, which are cellular precursors and indicators of an impending RA flare. The present disclosure further provides methods, kits and markers for identification and monitoring of flares in RA patients and their application as markers and targets in and for treatment of rheumatoid arthritis and conditions induced or related to rheumatoid arthritis. |
| FILED | Friday, November 25, 2022 |
| APPL NO | 17/994090 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084388 | Wheeler et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thurman Wheeler (Boston, Massachusetts); Xandra O. Breakefield (Newton Center, Massachusetts); Leonora Balaj (Charlestown, Massachusetts) |
| ABSTRACT | Described herein are methods for diagnosing and monitoring subjects with diseases associated with aberrant splicing, based upon detecting properly spliced isoforms and mis-spliced isoforms in a urine sample from the subject. |
| FILED | Wednesday, November 22, 2023 |
| APPL NO | 18/517748 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6865 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084394 | DENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Metabolomic Technologies Inc. (Edmonton, Canada) |
| ASSIGNEE(S) | Metabolomic Technologies Inc. (Edmonton, Canada) |
| INVENTOR(S) | Lu DENG (Edmonton, Canada); David Chang (Edmonton, Canada) |
| ABSTRACT | The invention relates to methods and compositions for detecting colorectal cancer and colorectal polyps by measurement of metabolites in bodily fluids such as urine, including diacetylspermine and kynurenine. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/386795 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/492 (20130101) G01N 33/493 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084400 | VILAR SANCHEZ et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Eduardo VILAR SANCHEZ (Houston, Texas); Wenhui WU (Houston, Texas); Hiroyuki KATAYAMA (Houston, Texas); Samir HANASH (Houston, Texas); Prashant V. BOMMI (Houston, Texas) |
| ABSTRACT | The current disclosure describes effective therapeutic treatments and diagnostic/prognostic methods for colorectal cancer based on the expression or activity level of biomarkers. Aspects of the disclosure relate to a method for treating a subject for colorectal cancer, the method comprising treating the subject for colorectal cancer after the expression level of one or more biomarker genes from Table 1, Table 2, Table 3, Table 4, Table 5, Table S2, Table S3, Table S4, Table S5, FIG. 4A, and/or FIG. 4B has been determined in a sample from the subject. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/547495 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57419 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084408 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changchun Liu (Farmington, Connecticut); Kun Yin (Farmington, Connecticut) |
| ABSTRACT | Described herein is an autonomous, rapid, sensitive, point-of-care target nucleic acid detection system and method based on CRISPR/Cas system. The system and method allow naked eye visualization of multiple target nucleic acid molecules simultaneously in a biological sample in less than an hour. Use of the system and method for multiplex gene diagnosis of SARS-CoV-2 is exemplified. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 18/262667 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) B01L 2200/16 (20130101) B01L 2200/0647 (20130101) B01L 2400/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085328 | Xu et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Ke Xu (Kensington, California); Kun Chen (El Cerrito, California); Rui Yan (Berkeley, California); Limin Xiang (El Cerrito, California) |
| ABSTRACT | Systems and methods are provided for excitation spectral microscopy using frame-synchronized acousto-optic scanning of fluorescent excitation wavelengths. Linear unmixing of the images of targets of components that are individually labeled with different fluorophores can be simultaneously imaged with high temporal resolution and low crosstalk and the local abundance of each fluorophore at each pixel can be quantified. Fluorophore decomposed micrographs of the sample can be obtained by rendering the abundance in each pixel as an image. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/484951 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) Original (OR) Class G01N 21/6458 (20130101) G01N 33/582 (20130101) G01N 2021/6439 (20130101) G01N 2201/067 (20130101) G01N 2201/0683 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085332 | Benman et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Benman (Philadelphia, Pennsylvania); Lukasz Bugaj (Philadelphia, Pennsylvania); Brian Chow (Philadelphia, Pennsylvania); Saachi Datta (Atlanta, Georgia); David Gonzalez-Martinez (Philadelphia, Pennsylvania); Jose Avalos (Princeton, New Jersey) |
| ABSTRACT | Provided herein is a stimulation and measurement device. The stimulation and measurement device includes a microwell plate having a top side, a bottom side, and at least one well extending from the top side towards the bottom side; a first assembly removably positioned on the top side of the microwell plate; a second assembly removably positioned on the bottom side of the microwell plate; and a microcontroller. The first assembly includes a first printed circuit board having at least one pair of stimulating light emitting diodes (LEDs) positioned thereon to align with one of the wells. The second assembly includes a second printed circuit board having at least one photodiode positioned thereon to align with one of the pairs of stimulating LEDs, and at least one excitation LED paired with each of the photodiodes. The microcontroller is configured to control the stimulating LED(s), the photodiode(s), and the excitation LED(s). |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/467469 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) Original (OR) Class G01N 2201/064 (20130101) G01N 2201/0446 (20130101) G01N 2201/0627 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085372 | Gundlach et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jens H. Gundlach (Seattle, Washington); Ian Michael Derrington (Seattle, Washington); Andrew Laszlo (Seattle, Washington); Jonathan Craig (Seattle, Washington); Henry Brinkerhoff (Seattle, Washington) |
| ABSTRACT | Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/475534 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44743 (20130101) Original (OR) Class G01N 27/44791 (20130101) G01N 33/6818 (20130101) G01N 33/48721 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085387 | Mookherjee et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Abhigya Mookherjee (Seattle, Washington); Miklos Guttman (Seattle, Washington) |
| ABSTRACT | The present disclosure provides a method of analyzing the structure of a glycan sample, the method including: receiving data indicative of one or more spectra of mass-to-charge ratio (m/z) versus relative abundance of the glycan sample from a mass spectrometer (MS) instrument; generating a ratio according to the following Equation: |
| FILED | Monday, June 05, 2023 |
| APPL NO | 18/329495 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/8603 (20130101) G01N 30/8631 (20130101) Original (OR) Class G01N 30/8679 (20130101) G01N 2030/027 (20130101) G01N 2030/862 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0072 (20130101) H01J 49/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085413 | Kimball et al. |
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| FUNDED BY |
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| APPLICANT(S) | Monell Chemical Senses Center (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce A. Kimball (Jenkintown, Pennsylvania); Gary K. Beauchamp (Philadelphia, Pennsylvania); Patrick Lennon Millet (Silver Spring, Maryland) |
| ABSTRACT | Assays and diagnostic devices for rapidly distinguishing between bacterial or viral sources of infection in a biological sample from mammalian subject are provided. A biological sample from said subject is contacted with a diagnostic reagent that detects at least one, or a pattern of multiple, volatile organic compounds (VOC). Detection of the VOC or a pattern of said VOC indicates a single source of infection selected from a Gram-positive bacterial infection, a Gram-negative bacterial infection, or a viral infection. In one embodiment, a dipstick diagnostic device permits rapid discrimination between bacterial or viral infection based upon the reaction of a detectable VOC reactive compound and optional label positioned on the dipstick surface. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 18/261625 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54386 (20130101) G01N 33/56911 (20130101) Original (OR) Class G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085422 | Garcia |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joe G.N. Garcia (Tucson, Arizona) |
| ABSTRACT | The present disclosure is directed to methods (e.g., in vitro methods) for use of nicotinamide phosphoribosyltransferase (NAMPT) as a biomarker in radiation-induced lung injury (RILI). Provided herein is an in vitro method for the diagnosis, prognosis, and/or monitoring of RILI in a human subject by providing a tissue or plasma sample from the subject and detecting the level of NAMPT therein, wherein a higher level of NAMPT in the tissue or plasma sample from the subject compared to a healthy control or a reference value is indicative for the presence of RILI in the subject. Further provided herein is a method of detecting NAMPT in a human subject by obtaining a biological sample from the subject, detecting the presence of NAMPT in the sample by contacting the sample with a capture agent that specifically binds NAMPT, and detecting binding between NAMPT and the capture agent. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/453286 |
| CURRENT CPC | Peptides C07K 16/40 (20130101) Enzymes C12Y 204/02012 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/534 (20130101) G01N 33/573 (20130101) Original (OR) Class G01N 33/5044 (20130101) G01N 2458/00 (20130101) G01N 2800/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085429 | Kenworthy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Anne Kathleen Kenworthy (Charlottesville, Virginia); Nico Fricke (Charlottesville, Virginia); Ajit Tiwari (Nashville, Tennessee); Charles R. Sanders (Nashville, Tennessee); Krishnan Raghunathan (Nashville, Tennessee); Hui Huang (Nashville, Tennessee); Ricardo F. Capone (Nashville, Tennessee); Joshua A. Bauer (Nashville, Tennessee); Katherine M. Stefanski (Nashville, Tennessee) |
| ABSTRACT | Disclosed are methods, including automated methods, for identifying a compound that impacts a characteristic of a lipid raft phase domain, a characteristic of a non-raft phase domain, and/or a characteristic of one or more membrane proteins. In some embodiments, the method comprises contacting a population of vesicles with a candidate compound, wherein a population of vesicles, wherein one or more vesicles in the population of optionally comprises one or more membrane proteins, with a candidate compound, wherein in a portion of the population of vesicles there is only a single detectable membrane phase and in a portion of the population of vesicles a membrane lipid raft phase domain and a membrane non-raft phase domain are phase separated; detecting a signal from the population of vesicles; and identifying the candidate compound as having an impact on a characteristic of a lipid raft phase domain, a characteristic of a non-raft phase domain, and/or a characteristic of one or more membrane proteins based on the signal. Systems and non-transitory computer readable medium comprising computer executable instructions embodied in a computer readable medium that when executed by a processor of a computer control the computer to perform steps of the method are also disclosed. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/273728 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/92 (20130101) G01N 33/582 (20130101) Original (OR) Class G01N 2021/6441 (20130101) G01N 2500/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085620 | WILLIAMS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KEITH J. WILLIAMS (Dunkirk, Maryland); Jason McKinney (West Lafayette, Indiana); John F. Diehl (Clinton, Maryland); John M. Singley (Elysburg, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KEITH J. WILLIAMS (Dunkirk, Maryland); Jason McKinney (West Lafayette, Indiana); John F. Diehl (Clinton, Maryland); John M. Singley (Elysburg, Pennsylvania) |
| ABSTRACT | An apparatus includes a finite impulse response demodulator. The finite impulse response demodulator includes least one stage. Each stage includes a cascaded pair of interferometers. The cascaded pair of interferometers includes a first interferometer and a second interferometer. Optionally, the first interferometer includes a first delay. The second interferometer includes a second delay. The first delay and the second delay are fixed or variable. Optionally, the first delay is unequal or equal to said second delay. Optionally, the first interferometer includes first internal power monitors, and the second interferometer includes second internal power monitors. The first power monitors monitor phase bias conditions within the first interferometer. The second power monitors monitor phase bias conditions within the second interferometer. Optionally, the first interferometer includes a first adjustable coupler, and the second interferometer comprises a second adjustable coupler. The second adjustable coupler communicates with the first interferometer. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/901983 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/12004 (20130101) Original (OR) Class G02B 6/12007 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085670 | SUN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheng SUN (Evanston, Illinois); Rihan HAI (Evanston, Illinois); Henry Oliver Tenadooah WARE (Evanston, Illinois); Evan Hunter JONES (Evanston, Illinois) |
| ABSTRACT | Provided herein are methods of making imaging systems. In one aspect, the method may comprise providing a lens; providing an optomechanical assembly; providing an imaging sensor; and operably connecting the optomechanical assembly with said lens and said imaging sensor, forming said imaging system. In some aspects, providing an optomechanical assembly may comprise manufacturing a component of the optomechanical assembly using additive manufacturing. In some aspects, providing an optomechanical assembly may comprise manufacturing a component of the optomechanical assembly using micro-continuous liquid interface production (μCLIP) 3D printing. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/367349 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00 (20130101) Optical Elements, Systems, or Apparatus G02B 7/003 (20130101) G02B 7/006 (20130101) G02B 7/022 (20130101) G02B 7/026 (20130101) G02B 13/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085681 | HILLMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Elizabeth M.C. HILLMAN (New York, New York); Wenxuan LIANG (Rushan, China PRC) |
| ABSTRACT | This application describes Swept, Confocally-Aligned Planar Excitation (SCAPE) microscopy systems that incorporate a gradient index (GRIN) lens to relay images from their distal tip to their proximal tip so that 3D images of deep tissue can be captured, without undue loss of light. A zero working distance feature can be designed into the third objective to ensure that the light that exits the second objective in the SCAPE system is not lost. Alternatively, a tapered fiber bundle may be positioned between the second objective and the third objective in the SCAPE system to ensure that the light that exits the second objective is not lost. As yet another alternative, direct detection at the intermediate image plane without using a third objective can ensure that the light that exits the second objective in the SCAPE system is not lost. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/388947 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/0087 (20130101) G02B 21/33 (20130101) G02B 21/0048 (20130101) G02B 21/0076 (20130101) Original (OR) Class G02B 21/361 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240086444 | Rensi |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Stefano Emanuele Rensi (Stanford, California) |
| ABSTRACT | Systems and methods for generating knowledge graphs and text summaries from document databases are provided. In one embodiment, a system for generating knowledge graphs and text summaries includes: a device, including: a processor; and a memory containing a knowledge graph and text summary generating application, where the knowledge graph and text summary generating application directs the processor to: query a global network of biomedical relationships; construct a knowledge graph and a citation graph; apply processes to learn local context-based weights and compute summarizations; and provide results via a display. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/754724 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/345 (20190101) Original (OR) Class G06F 16/367 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240087084 | SHROFF et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hari SHROFF (Bethesda, Maryland); Yicong WU (Bethesda, Maryland); Xiaofei HAN (Bethesda, Maryland); Patrick LA RIVIERE (Chicago, Illinois) |
| ABSTRACT | Various embodiments for systems and methods for producing one-dimensional super-resolved images from diffraction-limited line-confocal images using a trained neral network to generate a one-dimensional super-resolved output as well as an isotropic, in-plane super-resolved image are disclosed, wherein the neural network is trained using a training set comprising a plurality of matched training pairs, each training pair of the plurality of training pairs comprising a diffraction-limited line confocal image of the plurality of diffraction-limited line confocal images of the image type and a one dimensional super resolved image corresponding to the diffraction-limited line confocal image of the plurality of diffraction limited line confocal images. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 18/271202 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4046 (20130101) G06T 3/4053 (20130101) Original (OR) Class G06T 5/50 (20130101) G06T 2207/10056 (20130101) G06T 2207/20212 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240087671 | Zhi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida); The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Degui Zhi (Houston, Texas); Shaojie Zhang (Orlando, Florida); Ardalan Naseri (Houston, Texas); Ahsan Sanaullah (Orlando, Florida); Erwin Holzhauser (Orlando, Florida) |
| ABSTRACT | A system for indexing, updating, and search haplotypes for genetic genealogical discovery in genotype databases. The system includes a pool of genetic indexes, a haplotype ingestion engine, and a haplotype query engine. The haplotypes of a number of individuals in a genotype database are indexed by a pool of multiple panels, and each panel pool can be dynamically updated by the insertion or deletion of individual haplotypes. A genetic genealogical search of a query haplotype against the database is achieved by first projecting the query onto a subset of panels in the pool, then conducting long match queries over each panel, and finally aggregating the identified long matches into Identical-by-Descent segments, i.e., DNA matches, between the query and the haplotypes in the database. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505757 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/22 (20190101) G06F 16/24 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) Original (OR) Class G16B 20/20 (20190201) G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240087678 | Kuchroo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manik Kuchroo (New Haven, Connecticut); Smita Krishnaswamy (New Haven, Connecticut) |
| ABSTRACT | The present invention describes a CATCH assay for detecting cellular populations, biomarkers or biological interactions in a sample, and methods of use of the assay for identifying novel biomarkers of diseases and disorders and for diagnosing or treating diseases and disorders. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465301 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) Original (OR) Class G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240087868 | JARROLD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana); WATERS TECHNOLOGIES CORPORATION (Milford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. JARROLD (Bloomington, Indiana); Peyton SAYASITH (Bloomington, Indiana); Kevin GILES (Stockport, United Kingdom); David BRUTON (Congleton, United Kingdom) |
| ABSTRACT | A method is provided for controlling a multi-pole charged particle transmission device having rods spaced apart radially about a central axis extending from a particle inlet at one end of the device to a particle outlet at an opposite end. An AC voltage source is controlled to apply an AC voltage having a frequency, a peak amplitude, and a waveform shape to the charged particle transmission device, and a set of charged particles is passed through the device under such conditions. The AC voltage source is then controlled to change at least one of the frequency, peak amplitude or shape of the AC, and another set of the charged particles is then passed through the charged particle transmission device under such conditions. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/464063 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240087875 | JARROLD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. JARROLD (Bloomington, Indiana); David W. Reitenbach (Bloomington, Indiana) |
| ABSTRACT | A charged particle guide includes a plurality of electrically conductive segments radially spaced apart from one another about an opening defined axially through the segments, wherein the opening defines a central axis passing centrally and axially therethrough such that charged particles are received at one end of the opening and pass through an opposite end of the opening, at least one voltage source configured to produce and supply separate voltages to each of the segments, and at least one control circuit configured to control supply of selected voltages to the segments to create an electric field within the opening configured to cause charged particles entering the one end of the opening along a first axial path relative to the central axis to exit the opposite end of the opening along a second axial path relative to the central axis, wherein the first and second axial paths are not collinear. |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/463105 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/4225 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240081759 | TICHAUER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth M. TICHAUER (Chicago, Illinois); Scott C. DAVIS (Woodville, New Hampshire); Brian William POGUE (Hanover, New Hampshire) |
| ABSTRACT | An apparatus and method for medical imaging uses a first and second contrast agent, the second agent targeted to a particular tissue type. First images are obtained using the first agent, and second images using the second agent using medical imaging systems. An image processing system is adapted to process the first and second medical images by fitting parameters of a pharmacokinetic model to the first medical images, identifying a nontargeted tissue type, scaling the fitted parameters to best match the nontargeted tissue in the second medical images, executing the pharmacokinetic model to prepare a correction image, and generating corrected medical images by subtracting the correction image from the second medical images. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/389128 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 6/032 (20130101) A61B 6/037 (20130101) A61B 6/481 (20130101) Original (OR) Class A61B 6/4417 (20130101) A61B 6/5235 (20130101) A61B 6/5247 (20130101) Image Data Processing or Generation, in General G06T 5/50 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/20224 (20130101) G06T 2207/30024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240081893 | Farritor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shane Farritor (Lincoln, Nebraska); Tom Frederick (Gretna, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector. |
| FILED | Wednesday, November 01, 2023 |
| APPL NO | 18/499600 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1445 (20130101) Original (OR) Class A61B 2034/301 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082023 | Sobinov et al. |
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| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton Sobinov (Morgantown, West Virginia); Sergiy Yakovenko (Morgantown, West Virginia); Valeriya Gritsenko (Morgantown, West Virginia); Russell Hardesty (Sauquoit, New York); Matthew Boots (Fombell, Pennsylvania) |
| ABSTRACT | An approximation method and system are provided for more quickly controlling a prosthetic or other device by reducing computational processing time in a muscle model that can be used to control the prosthetic. For a given muscle, the approximation method can quickly compute polynomial structures for a muscle length and for each associated moment arms, which may be used to generate a torque for a joint position of a physics model. The physics model, in turn, produces a next joint position and velocity data for driving a prosthetic. The approximation method expands the polynomial structures as long as expansion is possible and sufficiently beneficial. The computations can be performed quickly by expanding the polynomial structures in a way that constrains the muscle length polynomial to the moment arm polynomial structures, and vice versa. |
| FILED | Monday, July 24, 2023 |
| APPL NO | 18/357999 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1107 (20130101) A61B 5/4519 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/70 (20130101) A61F 2/72 (20130101) Original (OR) Class A61F 2/582 (20130101) A61F 2002/6827 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/1075 (20130101) Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/015 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082233 | DOW et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 60 DEGREES PHARMACEUTICALS LLC (Washington, District of Columbia) |
| ASSIGNEE(S) | 60 DEGREES PHARMACEUTICALS LLC (Washington, District of Columbia); THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY (Fort Detrick, Maryland) |
| INVENTOR(S) | Geoffrey S. DOW (Washington, District of Columbia); Bryan L. SMITH (Chevy Chase, Maryland); John P. JONES (Richmond, Virginia); Moshe SHMUKLARSKY (Bethesda, Maryland); Budda BALASUBRAHMANYAM (Richmond, Virginia) |
| ABSTRACT | Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects. The methods of the invention further pertain to using the described algorithm to derive dosing regimens which can provide protection against symptomatic malaria in malaria-naïve, G6PD-normal subjects. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/240049 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4706 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) Heterocyclic Compounds C07D 215/40 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082405 | Kluge et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan A. Kluge (Southborough, Massachusetts); Fiorenzo G. Omenetto (Lexington, Massachusetts); David L. Kaplan (Concord, Massachusetts) |
| ABSTRACT | The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions. In some embodiments, the disclosure provides silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, the disclosure provides low molecular weight silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, an active agent is stabilized in a silk composition, e.g., for a period of time and/or against certain conditions or events. In some embodiments, a component present in a silk fibroin composition may be subject to analysis and/or characterization. In some embodiments, a component present in a silk fibroin composition may be recovered from the composition. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/829271 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/19 (20130101) A61K 38/1825 (20130101) A61K 47/42 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3604 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/24 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Peptides C07K 14/503 (20130101) C07K 14/43518 (20130101) C07K 14/43586 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082459 | Hasturk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tuffs College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Onur Hasturk (Medford, Massachusetts); Jaewon Choi (Medford, Massachusetts); David L. Kaplan (Concord, Massachusetts) |
| ABSTRACT | Tyramine-substituted silk fibroin compositions as well as methods for making and using the same are provided. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 17/768876 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/227 (20130101) Original (OR) Class A61L 27/3604 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082534 | DICARLO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | James DICARLO (Cambridge, Massachusetts); Pouya BASHIVAN (Cambridge, Massachusetts); Kohitij KAR (Arlington, Massachusetts) |
| ABSTRACT | Techniques for non-invasively controlling targeted neural activity of a subject are provided herein. The techniques include applying a stimulus input to the subject, the stimulus input being formed by a deep artificial neural network (ANN) model and being configured to elicit targeted neural activity within a brain of the subject. The stimulus input may be a pattern of luminous power generated by the deep ANN model and applied to retinae of the subject. The stimulus input may be generated by the deep ANN model based on a mapping of the subject's neural responses to neurons of the deep ANN model. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482806 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) A61B 5/378 (20210101) A61B 5/388 (20210101) A61B 5/7264 (20130101) A61B 2562/028 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 21/00 (20130101) Original (OR) Class A61M 2021/005 (20130101) A61M 2230/10 (20130101) A61M 2250/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082858 | Lozano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Paulo C. Lozano (Arlington, Massachusetts); Brian L. Wardle (Lexington, Massachusetts); Michael D. Canonica (Cambridge, Massachusetts); David Krejci (Wartberg, Austria); Yue Zhou (Brookings, South Dakota); Andrew Adams (Chapel Hill, North Carolina) |
| ABSTRACT | Polymeric electro spray emitters and related methods are generally described. In some embodiments, an emitter may be made from an ionic electro active polymer. The composition of the electro spray emitters described herein may enable the transport of ions and/or liquid ion sources, such as an ionic liquid or room temperature molten salt, through the bulk of the polymeric emitter. In some embodiments, the described emitters may be fabricated using a mixture of an ionic electroactive polymer, a solvent, and a liquid ion source to at least partially mitigate swelling effects of the polymer emitter that may otherwise occur when the one or more emitters are exposed to the liquid ion source during operation. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 18/272948 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/0255 (20130101) B05B 5/0533 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083279 | Loianno et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giuseppe Loianno (New York, New York); Alessandro Saviolo (Brooklyn, New York); Jeffrey Mao (Brooklyn, New York); Roshan Balu Thalaivirithan Margabandu Balakrishnan (Brooklyn, New York); Vivek Radhakrishnan (Brooklyn, New York) |
| ABSTRACT | A system for charging a battery in an aircraft comprises a ground station comprising an electrical connector configured to be connected to a source of power, a charging port comprising a plurality of electrical contacts a surface of the ground station, and at least one magnetic element positioned on the surface of the ground station, a tether configured to be connected at the proximal end to the aircraft, comprising an electrical connector at the proximal end configured to be connected to a battery of a aircraft, at least one tether magnetic element positioned at the distal end, and a tether charging connector positioned at the distal end, configured to electrically connect to the charging port when the at least one tether magnetic element is connected to the at least one ground station magnetic element. A method of charging an aircraft is also disclosed. |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/467202 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/16 (20190201) B60L 53/18 (20190201) B60L 53/36 (20190201) Original (OR) Class B60L 2200/10 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 10/60 (20230101) B64U 50/34 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083754 | Pate et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Bradford B. Pate (Arlington, Virginia); William Maza (Camp Spring, Maryland); Vanessa Breslin (Alexandria, Virginia); Paul A. DeSario (Alexandria, Virginia); Tatyana I. Feygelson (Springfield, Virginia); Albert Epshteyn (Potomac, Maryland); Jeffrey C. Owrutsky (Silver Spring, Maryland); Carlos Hangarter (Alexandria, Virginia) |
| ABSTRACT | Disclosed is a method of irradiating a composition having water and hydrogen-terminated nanodiamonds with light that generates water-solvated electrons from the nanodiamonds. The method can be used to degrade fluoroalkyl compounds such as perfluorooctane sulfonate. |
| FILED | Tuesday, November 21, 2023 |
| APPL NO | 18/515338 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/123 (20130101) B01J 2219/089 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/28 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083859 | Spiegel et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); David CAIANIELLO (New Haven, Connecticut) |
| ABSTRACT | The present invention is directed to bi-functional compounds which find use as pharmaceutical agents in the treatment of disease states and/or conditions which are mediated through macrophage migration inhibitory factor (MIF) or immunoglubin G (IgG). The present invention is also directed to pharmaceutical compositions which comprise these bi-functional compounds as well as methods for treating disease states and/or conditions which are mediated through MIF/IgG or where MIF/IgG is a contributing factor to the development and perpetuation of diseases and/or conditions, especially including autoimmune diseases and cancer, among others. The purpose of the present invention is to provide a molecular strategy to lower plasma MIF/IgG level in patients with autoimmune diseases or certain types of cancers. The bi-functional molecule construct is comprised of a MIF/IgG-targeting motif, that is derived from small molecule MIF/IgG ligands, and an ASGPr-targeting motif that binds to hepatocyte asialoglycoprotein receptor (ASGPr). The compounds selectively bind MIF or IgG in plasma and subsequently engage the endo-lysosomal pathway of hepatocytes through ASGPr. As a consequence, MIF/IgG is internalized and degraded by hepatocytes, thus resulting in potential attenuation of corresponding disease symptoms which are modulated through MIF/IgG. |
| FILED | Tuesday, August 08, 2023 |
| APPL NO | 18/446296 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 249/04 (20130101) Original (OR) Class C07D 413/14 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084034 | MARIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania); THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY (Rockville, Maryland) |
| ASSIGNEE(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania); THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY (Bethesda, Maryland) |
| INVENTOR(S) | John M. MARIS (Phildelphia, Pennsylvania); Kristopher R. BOSSE (Philadelphia, Pennsylvania); Dimiter DIMITROV (Frederick, Maryland); Zhongyu ZHU (Frederick, Maryland); Dontcho V. JELEV (Rockville, Maryland) |
| ABSTRACT | The present disclosure is directed to antibodies binding to Glypican 2 and methods of using such antibodies to treat cancers that express or overexpress the Glypican 2 antigen. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/499054 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 47/6889 (20170801) A61K 47/6929 (20170801) A61K 2039/572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/18 (20130101) C07K 16/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084235 | Fernandez-Alcon et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose Fernandez-Alcon (Cambridge, Massachusetts); Norman Wen (Newton, Massachusetts); Richard Novak (Jamaica Plain, Massachusetts); Donald E. Ingber (Boston, Massachusetts); Geraldine A. Hamilton (Cambridge, Massachusetts); Christopher Hinojosa (Cambridge, Massachusetts); Karel Domansky (Charlestown, Massachusetts); Daniel Levner (Cambridge, Massachusetts); Guy Thompson, II (Lexington, Massachusetts); Kambez Hajipouran Benam (Cambridge, Massachusetts); Remi Villenave (Boston, Massachusetts); Thomas Umundum (Salzburg, Austria); Alfred Paris (Salzburg, Austria); Georg Bauer (Salzburg, Austria) |
| ABSTRACT | An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470404 |
| CURRENT CPC | Separation B01D 61/18 (20130101) B01D 63/081 (20130101) B01D 67/0023 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502753 (20130101) B01L 2200/12 (20130101) B01L 2200/0647 (20130101) B01L 2300/0645 (20130101) B01L 2300/0887 (20130101) B01L 2400/0487 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/26 (20130101) C12M 25/02 (20130101) C12M 35/04 (20130101) C12M 41/00 (20130101) C12M 41/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084323 | Manfredsson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dignity Health (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fredric Manfredsson (San Francisco, California); Robert Bowser (San Francisco, California) |
| ABSTRACT | Compositions and methods for modifying the expression of one or more chitinase proteins in a target cell or tissue type are disclosed. The compositions can be used in methods of treating a disease condition associated with expression of a chitinase protein in a cell or tissue type in a subject in need thereof, such as ALS and PD. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 18/261319 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2442 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 15/1137 (20130101) C12N 2310/20 (20170501) C12N 2310/141 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084360 | Ismagilov et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. Ismagilov (Altadena, California); Natalie Wu-Woods (Pasadena, California); Jacob T. Barlow (Cambridge, Massachusetts); Anna E. Romano (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems to selectively deplete a biological sample of host compartments and/or host nucleic acid while enriching the sample microbial compartments and/or related microbial nucleic acid. In addition, provided herein are compositions, methods and systems related to said host depletion and microbial enrichment methods and systems. |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/351461 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085131 | Howell et al. |
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| FUNDED BY |
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| APPLICANT(S) | James E. Howell (Fredericksburg, Virginia); Matthew James O'Neill (Fredericksburg, Virginia); Jonathan F. Pfab (Richmond, Virginia); Vernon Todd Davis (King George, Virginia); Vincent J. Vendetti (King George, Virginia); Carl S. Lynn, IV (Fredericksburg, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | James E. Howell (Fredericksburg, Virginia); Matthew James O'Neill (Fredericksburg, Virginia); Jonathan F. Pfab (Richmond, Virginia); Vernon Todd Davis (King George, Virginia); Vincent J. Vendetti (King George, Virginia); Carl S. Lynn, IV (Fredericksburg, Virginia) |
| ABSTRACT | A mounting platform is provided for securing munitions. The platform includes a flat plate, a front block and a rear block. The plate includes a plurality of cutout holes. The front block has a first saddle disposed between first flanking ends and at least one extension at one of the flanking ends for inserting into a first opening of the cutouts. The rear block has a second saddle disposed between second flanking ends at least one extension for inserting into a second opening of the cutouts. The munitions are disposable atop the first and second saddles of the front and rear blocks. The munitions are restrained axially against a rear stop block and laterally by the saddles and straps. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/942719 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 9/87 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085160 | STORY et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRITON SYSTEMS, INC. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William STORY (Southbridge, Massachusetts); Arthur Gavrin (Manchester, New Hampshire) |
| ABSTRACT | Disclosed herein are methods of making fragmentation casings for bombs and warheads. Particularly, cold spray methods are used. A layer or layers of metal, metal alloy, and optional other materials are deposited by cold spray application of cold spray materials to preform/mandrel, having patterned structures to define fragmentation points (e.g., stress concentrators) in a fragmentation casing formed on the preform/mandrel via cold spray. In addition to such cold spray processes for forming a fragmentation casing, this disclosure relates to the preform/mandrels used as well as the resultant fragmentation casing formed via cold spray. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/465013 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 24/04 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 3/28 (20130101) F42B 33/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085274 | NIU et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | GUANGXING NIU (WEST COLUMBIA, South Carolina); BIN ZHANG (IRMO, South Carolina) |
| ABSTRACT | A system and method concerns accurate bearing fault diagnosis and prognosis (FDP), critical for optimal maintenance schedules, safety and reliability. Existing methods face challenges: the bearing condition is healthy in most of the service time, so it is critical to detect the occurrence of faults and the start point for prognosis in real applications. Due to differences in manufacturing quality, assembly quality, and different operating conditions, it is difficult to describe the fault dynamic using one single fault model. A hybrid Bayesian estimation-based bearing FDP framework with fault detection and automatic fault model selection is disclosed. A convolutional neural network is used to detect fault and select the appropriate fault dynamic model. To improve performance with different bearings under different operating conditions, continuous wavelet coefficient matrices power spectrum of vibration are fused with operating conditions to build information maps for fault detection and model selection. After a fault is detected, a Bayesian estimation based FDP method is triggered to estimate the fault state and predict the remaining useful life. In the prognostic process, Dempster-Shafer theory is employed to fuse prediction results from different models if necessary. |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/462471 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 13/045 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/045 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085292 | Burns et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sloan C. Burns (King George, Virginia); Luke Andrew Martin, II (King George, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Sloan C. Burns (King George, Virginia); Luke Andrew Martin, II (King George, Virginia) |
| ABSTRACT | A test fixture is provided for dropping an article from a height to a floor, with the article oriented in relation to the floor at a select angle. The fixture includes a column frame, an overhead beam, a carriage, first and second guy wires, first and second spools, and first and second chains. The frame supports first and second guide arms on opposing sides. The overhead beam has a distance span substantially parallel to the floor. The carriage is disposed substantially parallel to the floor and has first and second opposing guides separated by the span. The guy wires attach to the beam separated the span and pass through the guide arms. The first and second spools to receive the corresponding guy wires. The first and second chains suspend the article from the carriage above the floor. Upon release of the guy wires, the carriage falls until contact with the guide arms while the article contacts the floor. Additionally, rods connected at the ends of article and suspended from the carriage to further ensure the article's angle. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/942356 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/02 (20130101) G01N 3/303 (20130101) Original (OR) Class G01N 2203/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085363 | Mirica et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Katherine A. Mirica (Hanover, New Hampshire); Lukasz K. Mendecki (White River Junction, Vermont); Michael Ko (West Lebanon, New Hampshire); Zheng Meng (West Lebanon, New Hampshire); Robert M. Stolz (Lyme, New Hampshire); Aileen Eagleton (Hanover, New Hampshire) |
| ABSTRACT | In some embodiments, the present disclosure pertains to methods of detecting an analyte in a sample by associating the sample with an electrode that includes a metal-organic framework. After association, the redox properties of the electrode are evaluated. Thereafter, the presence or absence of the analyte in the sample is detected by correlating the redox properties of the electrode to the presence or absence of the analyte. In some embodiments, the present disclosure pertains to electrodes that include a metal-organic framework and an electrode surface. In particular embodiments of the present disclosure, the metal-organic framework is associated with the electrode surface. Additional embodiments of the present disclosure pertain to methods of making the electrodes of the present disclosure by associating a metal-organic framework with an electrode surface. In some embodiments, the methods of the present disclosure also include a step of mixing the metal-organic framework with a polymer. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/388179 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) C07F 15/04 (20130101) C07F 15/006 (20130101) C07F 15/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3277 (20130101) G01N 27/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085434 | Mauzy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Camilla A. Mauzy (Enon, Ohio); James P. Karl (Roslindale, Massachusetts) |
| ABSTRACT | A method of predicting acute mountain sickness (AMS). The method includes collecting a urine sample from a subject and analyzing the urine sample for a quantity of at least one metabolite selected from the group consisting of creatine, taurine, N-methylhistidine, hypoxanthine, 1-methylnicotinamide, 4-hydroxyphenylpyruvate, acetylcarnitine, and 3-methylhistidine. The quantity is compared to a threshold value for the respective metabolite. Based on the comparison, it is determined whether the subject is susceptible to experience AMS at high altitudes. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/464365 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/08 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085441 | ROLLER et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachel Marie ROLLER (South Bend, Indiana); Marya LIEBERMAN (South Bend, Indiana) |
| ABSTRACT | A paper analytical device for detecting an analyte in a sample, and methods of fabricating and using the same. A paper analytical device may include laminated strips of a porous hydrophilic substrate and an adhesive layer. The laminated strips may be disposed on a hydrophobic backing with an air gap barrier between each laminated strip that is about 1 mm to about 5 mm in width and extends along the entire length of the laminated strip. A paper analytical device also may include one or more assay regions having one or more reagents for detecting an analyte, and sample deposition areas for receiving a test sample. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/453116 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 2200/12 (20130101) B01L 2200/16 (20130101) B01L 2300/021 (20130101) B01L 2300/069 (20130101) B01L 2300/0681 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085620 | WILLIAMS et al. |
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| FUNDED BY |
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| APPLICANT(S) | KEITH J. WILLIAMS (Dunkirk, Maryland); Jason McKinney (West Lafayette, Indiana); John F. Diehl (Clinton, Maryland); John M. Singley (Elysburg, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KEITH J. WILLIAMS (Dunkirk, Maryland); Jason McKinney (West Lafayette, Indiana); John F. Diehl (Clinton, Maryland); John M. Singley (Elysburg, Pennsylvania) |
| ABSTRACT | An apparatus includes a finite impulse response demodulator. The finite impulse response demodulator includes least one stage. Each stage includes a cascaded pair of interferometers. The cascaded pair of interferometers includes a first interferometer and a second interferometer. Optionally, the first interferometer includes a first delay. The second interferometer includes a second delay. The first delay and the second delay are fixed or variable. Optionally, the first delay is unequal or equal to said second delay. Optionally, the first interferometer includes first internal power monitors, and the second interferometer includes second internal power monitors. The first power monitors monitor phase bias conditions within the first interferometer. The second power monitors monitor phase bias conditions within the second interferometer. Optionally, the first interferometer includes a first adjustable coupler, and the second interferometer comprises a second adjustable coupler. The second adjustable coupler communicates with the first interferometer. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/901983 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/12004 (20130101) Original (OR) Class G02B 6/12007 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240086200 | Brewer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Devices and techniques for self-scheduling threads in a programmable atomic unit are described herein. When it is determined that an instruction will not complete within a threshold prior to insertion into a pipeline of the processor, a thread identifier (ID) can be passed with the instruction. Here, the thread ID corresponds to a thread of the instruction. When a response to completion of the instruction is received that includes the thread ID, the thread is rescheduled using the thread ID in the response. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/378281 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/48 (20130101) G06F 9/3836 (20130101) G06F 9/3851 (20130101) Original (OR) Class G06F 9/3867 (20130101) G06F 9/4887 (20130101) G06F 15/7825 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 25/0655 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240086554 | Daughety et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); The United States of America as represented by the Secretary of the Air Force (JBSA-Lackland, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Daughety (Pleasant Plain, Ohio); Marcus Pendleton (San Antonio, Texas); Shouhuai Xu (Colorado Springs, Colorado); Laurent L. Njilla (Liverpool, New York); Tyler Reuther (San Antonio, Texas) |
| ABSTRACT | A cross-domain solution architecture includes a higher-security domain and a lower-security domain. The higher-security domain (i) processes data on a higher-security level, and (ii) includes a hardware-based trusted executed environment (TEE) running a formally verified microkernel. The lower-security domain (i) processes data on a lower-security level having lower security than the higher-security level, and (ii) includes a trusted computer base (TCB). The TCB operates in the higher-security domain and the lower-security domain to pass data from the lower-security domain to the higher-security domain through a first data diode, and to pass data from the higher-security domain to the lower-security domain through a second data diode. |
| FILED | Saturday, April 22, 2023 |
| APPL NO | 18/138053 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/604 (20130101) Original (OR) Class G06F 2221/2113 (20130101) G06F 2221/2141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240087475 | SMOLEK |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Govemment of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael K. SMOLEK (Pearl River, Louisiana) |
| ABSTRACT | A surrogate human model eye, comprising: (a) a gelatin core; (b) a sclera; (c) an anterior chamber; (d) a posterior chamber; (e) a cornea; (f) an optic nerve and (g) an outer shell structure based on a hydrogel matrix, wherein said surrogate human model eye is made from a silicone-based master mold and dimensioned for replacement of postmortem ocular tissue and practice in blast research and testing. Methods are provided for practicing blast research and testing on a surrogate human eye model comprising: supplying a surrogate human eye model comprising: (a) a gelatin core; (b) a sclera; (c) an anterior chamber; (d) a posterior chamber; (e) a cornea; (f) an optic nerve and (g) an outer shell structure based on a hydrogel matrix, wherein said surrogate human model eye is made from a silicone-based master mold and dimensioned for replacement of postmortem ocular tissue. |
| FILED | Monday, November 18, 2019 |
| APPL NO | 17/767863 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088903 | Chieh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia-Chi Samuel Chieh (San Diego, California); Henry Ngo (San Diego, California) |
| ABSTRACT | A non-linear charge pump for phased lock loops. Furthermore, an auxiliary charge pump apparatus, comprising a positive switch electrically connected to a current source configured to supplement power to a charge pump, a negative switch electrically connected to a current sink configured to discharge power from the charge pump, a windowing comparator, further comprising an input signal received from a phase-locked loop, a first comparator configured to compare the input signal against a high voltage threshold, a second comparator configured to compare the input signal against a low voltage threshold, an AND logic gate configured to provide a window signal and an activation circuit electrically connected to the positive switch and negative switch. Additionally, a non-linear charge pump system and method for reacquiring frequency lock of a phase lock loop. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/931661 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/07 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/0895 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240089286 | Atighetchi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Hassan Atighetchi (Framingham, Massachusetts); Stephane Yannick Blais (Framingham, Massachusetts); Katarzyna Lucia Olejnik (Brookline, Massachusetts) |
| ABSTRACT | Techniques for evaluating cyber assets are disclosed. A system obtains, from data sources in an experimental environment, raw data generated in response to execution of a cyber asset. The system generates, from the raw data, at least one instance model corresponding to the data sources. The at least one instance model includes instances of concepts represented in a cyber impact ontology. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/513768 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/20 (20130101) H04L 63/1433 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240089863 | El-Jamous et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTELLIGENT AUTOMATION, LLC (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ziad El-Jamous (Rockville, Maryland); Yalin Evren Sagduyu (Gaithersburg, Maryland); Kemal Davaslioglu (Ellicott City, Maryland) |
| ABSTRACT | Wireless networks with plural nodes having a respective transceiver and a processor configured to, and methods to, obtain current state data, calculate a reward, store such state data and rewards in a collected parameters database, provide such current state data and data from such collected parameters database to a reinforced neural network, select an action using the reinforced neural network, and output the action to the respective transceiver so as to selective modify its transmit power level. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505749 |
| CURRENT CPC | Wireless Communication Networks H04W 52/06 (20130101) H04W 52/223 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240090091 | Kessler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Metis Design Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seth S. Kessler (Newton, Massachusetts); Gregory A. Thomas (San Francisco, California); Christopher T. Dunn (Salem, Massachusetts); Michael Borgen (Wilmington, Massachusetts); Brian L. Wardle (Lexington, Massachusetts) |
| ABSTRACT | A multifunctional assembly having a resistive element a conductive element in electrical communication with the resistive element, the conductive element defining at least one of a plurality of multifunctional zones of the resistive element, wherein the conductive element is configured to direct a flow of electricity across at least one of the plurality of multifunctional zones of the resistive element in a preselected manner. |
| FILED | Friday, April 14, 2023 |
| APPL NO | 18/135058 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) Resistors H01C 13/00 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/33 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 1/0236 (20130101) H05B 3/20 (20130101) H05B 3/145 (20130101) H05B 3/265 (20130101) H05B 3/267 (20130101) H05B 6/101 (20130101) Original (OR) Class H05B 2203/011 (20130101) H05B 2203/013 (20130101) H05B 2203/016 (20130101) H05B 2203/017 (20130101) H05B 2214/02 (20130101) H05B 2214/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240090126 | Lazarus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan S. Lazarus (Bear, Delaware); Adam L. Bachmann (Tampa, Florida); Michael D. Dickey (Raleigh, North Carolina) |
| ABSTRACT | A novel methodology of forming a three-dimensional electronic device according to various embodiments of the present invention is described. The methodology comprises, at least, a step of laser folding, using only a laser, a two-dimensional electrically insulating printed circuit board at least partially covered with at least one metal layer, with the laser impinging upon the at least one metal layer to make one or more folds of the printed circuit board to form a three-dimensional electronic device structure. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944857 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/028 (20130101) Original (OR) Class H05K 3/0026 (20130101) H05K 2201/055 (20130101) H05K 2203/302 (20130101) H05K 2203/1105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240081654 | BALDWIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NICHE BIOMEDICAL, INC. (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Barnes BALDWIN (Santa Monica, California); Yi-Kai LO (Culver City, California) |
| ABSTRACT | Systems and methods that can employ a bleeding sensor that uses an optical mechanism to detect blood in the patients GI tract are described. The bleeding sensor includes a substrate holding a centrally-located light detector with a broad sensitivity spectrum and at least two light emitters positioned radially around the centrally-located light detector, each light emitter configured to emit light of different primary wavelengths. The bleeding sensor has a gap between each of the at least two light emitters and the centrally-located light detector that accepts the contents of a patients gastrointestinal tract. An optical cap covers the centrally-located light detector and the at least two light emitters to direct the light emitted from the at least two light emitters through the gap and onto the centrally-located light detector. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 18/554527 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0086 (20130101) A61B 5/02042 (20130101) Original (OR) Class A61B 5/4222 (20130101) A61B 5/6861 (20130101) A61B 5/7225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240081657 | Atashzar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyed Farokh Atashzar (New York, New York); Yao Wang (Livingston, New Jersey); Daniel Sterman (Radnor, Pennsylvania) |
| ABSTRACT | The present invention provides a smart wearable IOT device configured to be worn by a subject on the body and is capable of continuously tracking and reporting a plurality of vital signs and physical activities of the user, including but not limited to sound and vibrational dynamics due to breathing and coughing (from which we can derive the breathing and coughing types and features), body temperature, peripheral oxygen saturation (SpO2), heart rate, and fatigue-related mobility, physical ability, step count, photoplethysmogram (PPG), ECG, heart rate, heart rate variability, etc. In one aspect, the wearable system will be able to measure the distance with different users through the transmit and receive of Bluetooth low energy signals or WiFi to trace contacts between different wearers. The system will be able to record the data locally on a SD card and also will be able to upload on a server. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508879 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0015 (20130101) A61B 5/0205 (20130101) Original (OR) Class A61B 5/6814 (20130101) A61B 5/6822 (20130101) A61B 5/6831 (20130101) A61B 5/6832 (20130101) A61B 2560/06 (20130101) A61B 2560/045 (20130101) A61B 2560/0247 (20130101) A61B 2560/0406 (20130101) A61B 2560/0462 (20130101) A61B 2560/0475 (20130101) A61B 2562/0204 (20130101) A61B 2562/0219 (20130101) A61B 2562/0223 (20130101) A61B 2562/0257 (20130101) A61B 2562/0271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240081711 | Tian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Limei Tian (College Station, Texas); Myeong Namkoong (College Station, Texas) |
| ABSTRACT | A flexible electrode includes a layer of an interpenetrating network of silver nanowires and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), and a core comprising a foam. The layer of interpenetrating network of silver nanowires and PEDOT:PSS are wrapped around the core. A wearable device includes a current source comprising a pair of outer electrodes, and voltage sensors comprising one or two pairs of internal electrodes that are arranged between the outer electrodes. At least one electrode of these electrodes is a flexible electrode. |
| FILED | Tuesday, August 29, 2023 |
| APPL NO | 18/239306 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/256 (20210101) A61B 5/268 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240081893 | Farritor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shane Farritor (Lincoln, Nebraska); Tom Frederick (Gretna, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector. |
| FILED | Wednesday, November 01, 2023 |
| APPL NO | 18/499600 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1445 (20130101) Original (OR) Class A61B 2034/301 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082210 | Lopez-Mejias et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vilmali Lopez-Mejias (San Juan, Puerto Rico); Jeaninna P. Flores Bello (San Juan, Puerto Rico); Israel Rodriguez Rodriguez (San Juan, Puerto Rico); Joyce Marie Serrano Valcarcel (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vilmali Lopez-Mejias (San Juan, Puerto Rico); Jeaninna P. Flores Bello (San Juan, Puerto Rico); Israel Rodriguez Rodriguez (San Juan, Puerto Rico); Joyce Marie Serrano Valcarcel (San Juan, Puerto Rico) |
| ABSTRACT | A series of pharmaceutical metal complexes (pMCs) were produced and characterized using the mast cell stabilizer, cromolyn, and bioactive metal ions (Zn+2, Mg+2, and Ca+2). Three novel pMCs, Cromolyn-Zn, Cromolyn-Mg, and Cromolyn-Ca were formed through reactions under controlled temperature and pH conditions. TGA demonstrated that these metal complexes showed an enhanced thermal stability due to the strong coordination with the ligand, cromolyn. PXRD data indicates a high degree of crystallinity as well as a unique packing arrangement for each pMCs. SEM analysis showed materials with well-defined morphologies while EDS presented elemental evidence for the unique composition of each pMCs. The crystal structure for these materials was elucidated through SCXRD, and a variety of binding modes and packing motifs were found within each respective metal complex. Only 2D structures were achieved under the conditions studied. Dissolution studies show high stability and slow degradation for the metal complexes, while a higher dissolution was observed for the drug compound in PBS. Neither CS nor the pMCs dissolved significantly in FaSSGF at 37° C. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/515252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082318 | Catania et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chelsea Catania (Somerville, Massachusetts); Ariel Furst (Cambridge, Massachusetts); Gang Fan (Jamaica Plain, Massachusetts); Pris Wasuwanich (Orlando, Florida) |
| ABSTRACT | Prokaryotic cells having a metal-phenolic network coating are disclosed, as are compositions including such cells, methods for their use, and methods for producing such cells. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/476900 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/135 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/742 (20130101) Original (OR) Class A61K 47/52 (20170801) A61K 47/6903 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082899 | SMITH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Keystone Tower Systems, Inc. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric D. SMITH (Denver, Colorado); Rosalind K. TAKATA (Denver, Colorado); Daniel AINGE (Boulder, Colorado); Loren Daniel BRIDGERS (Golden, Colorado) |
| ABSTRACT | Spiral forming methods can be used to join edges of a rolled material along a spiral joint to form conical and/or cylindrical structures. Alignment of the edges of the rolled material can be controlled in a wrapping direction as the material is being joined along the spiral joint to form the structure. By controlling alignment of the edges of the material as the edges of the material are being joined, small corrections can be made over the course of forming the structure facilitating control over geometric tolerances of the resulting spiral formed structure. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/344230 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/12 (20130101) B21C 37/122 (20130101) B21C 37/124 (20130101) B21C 37/128 (20130101) Original (OR) Class B21C 37/185 (20130101) Wind Motors F03D 13/20 (20160501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082912 | Mack et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Benjamin Mack (Chesterfield, Missouri); Samuel Mark Pennell (Chicago, Illinois); David C. Dunand (Evanston, Illinois) |
| ABSTRACT | This invention in one aspect relates to an iron-based foam usable for an electrochemical device, comprising a composition comprising iron and a refractory element processed to form the iron-based foam having a hierarchical porous structure with self-assembled channels for gas flow reactions and internal space to accommodate volumetric changes on oxidation. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/367019 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1017 (20130101) B22F 3/1143 (20130101) Original (OR) Class B22F 9/04 (20130101) B22F 2009/043 (20130101) B22F 2301/35 (20130101) B22F 2998/10 (20130101) B22F 2999/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/0084 (20130101) Alloys C22C 38/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082920 | Schiffres et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott N. Schiffres (Vestal, New York); Arad Azizi (Alborz, Iran); Changhong Ke (Binghamton, New York); Bahgat Sammakia (Binghamton, New York); Feilin Gou (Vestal, New York) |
| ABSTRACT | A technique for additively manufacturing with a segmentation exposure strategy is disclosed herein, which enables lower thermal stress and substrate temperatures, compared to conventional raster strategies. The technique enables manufacture of heat removal devices and other deposited structures, especially on heat sensitive substrates where coefficient of thermal expansion mismatch can be considerable. It also enables novel composites through additive manufacturing. This process can also be selectively applied to parts or material systems that have large thermal stresses with conventional raster and process parameters to reduce chances of thermal stress induced failure. The process enables reduction of heat concentration in selective laser melting or electron beam melting which results in lower residual stresses in the fabricated object. |
| FILED | Tuesday, May 16, 2023 |
| APPL NO | 18/318670 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/85 (20210101) B22F 10/362 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/10 (20200101) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082922 | MORIDI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Atieh MORIDI (Ithaca, New York); Jennifer BUSTILLOS (Ithaca, New York) |
| ABSTRACT | The technologies disclosed herein relate to systems and methods of manufacturing an alloy. In accordance with various embodiments, the alloy produced via the disclosed systems and/or methods include engineering of duplex microstructures in the alloy to improve poor mechanical performance of additive manufactured metals. In various embodiments, the alloy may be subjected to thermo-mechanical treatment where simultaneous heat and pressure is applied with a deliberately high density of fusion defects. In accordance with various embodiments, the systems and methods disclosed in the present application have the potential to improve damage tolerance of critical structures experiencing fatigue loading and impact loading. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 18/260582 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/64 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082952 | Brooks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel R. Brooks (Rochester, New York); Jonathan D, Ellis (Tuscon, Arizona) |
| ABSTRACT | A pre-objective two-degree-of-freedom galvanometer scanning system including two galvo mirrors (111,112) with an optical relay (120) between the mirrors (111,112) and a microscope objective (130) with a curved image plane (140) is presented. The second galvo mirror (112) is located in the aperture stop before the objective. The optical system enables scanning in both directions over the full, curved field for creating custom refractive structures across the 6.5 mm optical zone of contact lenses using femtosecond micro-modification. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508756 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/082 (20151001) Original (OR) Class B23K 26/0624 (20151001) B23K 26/0648 (20130101) Optical Elements, Systems, or Apparatus G02B 13/0005 (20130101) G02B 13/0095 (20130101) G02B 26/101 (20130101) G02B 26/105 (20130101) G02B 27/0031 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083279 | Loianno et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giuseppe Loianno (New York, New York); Alessandro Saviolo (Brooklyn, New York); Jeffrey Mao (Brooklyn, New York); Roshan Balu Thalaivirithan Margabandu Balakrishnan (Brooklyn, New York); Vivek Radhakrishnan (Brooklyn, New York) |
| ABSTRACT | A system for charging a battery in an aircraft comprises a ground station comprising an electrical connector configured to be connected to a source of power, a charging port comprising a plurality of electrical contacts a surface of the ground station, and at least one magnetic element positioned on the surface of the ground station, a tether configured to be connected at the proximal end to the aircraft, comprising an electrical connector at the proximal end configured to be connected to a battery of a aircraft, at least one tether magnetic element positioned at the distal end, and a tether charging connector positioned at the distal end, configured to electrically connect to the charging port when the at least one tether magnetic element is connected to the at least one ground station magnetic element. A method of charging an aircraft is also disclosed. |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/467202 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/16 (20190201) B60L 53/18 (20190201) B60L 53/36 (20190201) Original (OR) Class B60L 2200/10 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 10/60 (20230101) B64U 50/34 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083753 | Bedewy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mostafa Bedewy (McDonald, Pennsylvania); Moataz Magdi Mahmoud Amin Abdulhafez (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of producing a carbonized material includes applying a beam of electromagnetic radiation from a laser source to a polymeric substrate, varying the position of the beam to traverse over at least a portion of a surface of the polymeric substrate in a predetermined pattern, and controlling a fluence of the beam and speed of movement of the beam traversing over the at least a portion of the surface of the polymeric substrate as a function of position on the surface to one or more predefined levels effluence and speed of movement of the beam to control at least one property of the produced carbonized material. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/262439 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083952 | Chilkoti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh Chilkoti (Durham, North Carolina); Stefan Roberts (Raleigh, North Carolina) |
| ABSTRACT | Disclosed herein are partially ordered polypeptides, which include a plurality of disordered domains and a plurality of structured domains. The partially ordered polypeptides may have phase transition behavior and form aggregates at, above, or below certain temperatures. Further provided are cellular scaffolds comprised of the partially ordered polypeptides. |
| FILED | Wednesday, April 19, 2023 |
| APPL NO | 18/303530 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/5169 (20130101) A61K 35/12 (20130101) A61K 35/74 (20130101) Peptides C07K 14/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083957 | BONDOS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BONDWELL TECHNOLOGIES LP (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah E. BONDOS (College Station, Texas); Alexandra M. WHITELEY (Houston, Texas); Kathleen S. MATTHEWS (Houston, Texas); Zhao HUANG (Houston, Texas); Autumn BRAWLEY (College Station, Texas); Jan PATTERSON (College Station, Texas) |
| ABSTRACT | The present disclosure relates, in some embodiments, to a composition comprising a biomaterial. A biomaterial may comprise, for example, one or more molecules capable of self-association and/or self-assembly. In some embodiments, a biomaterial may comprise one or more polypeptides and/or proteins. A biomaterial may comprise, for example, two or more self-assembled Ultrabithorax (Ubx) protein molecules. A Ubx protein, in some embodiments, may be any wild type Drosophila melanogaster Ultrabithorax protein, including any natural or non-natural isoforms (e.g., alternative splicing isoforms). The present disclosure relates, in some embodiments, to a method of making a biomaterial comprising contacting two or more Ubx protein molecules under conditions that permit self-assembly to form a first fibril and contacting the first fibril to a second fibril. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/182726 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083982 | Olafson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Protabit LLC (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barry D. Olafson (Pasadena, California); Stephen L. Mayo (Pasadena, California); Pamela J. Bjorkman (Altadena, California); Jost G. Vielmetter (Pasadena, California); Justin W. Chartron (Pasadena, California); Paul M. Chang (Pasadena, California); Stephanie C. Contreras (Folsom, California); Jingzhou Wang (Pasadena, California); Aiden J. Aceves (Pasadena, California); Anthony P. West, Jr. (Pasadena, California); Christopher O. Barnes (Pasadena, California); Jennifer R. Keeffe (Los Angeles, California); Claudia A. Jette (Pasadena, California) |
| ABSTRACT | Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein. Also provided are compositions, methods, and kits for using said antibodies or fragments thereof for preventing or treating, for example a coronavirus infection. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356810 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1003 (20230801) Original (OR) Class C07K 2317/55 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084110 | Fini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Elham Fini (Phoenix, Arizona); Dong-Kyun Seo (Chandler, Arizona); Sand Aldagari (Tempe, Arizona); Masoumeh Mousavi (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elham Fini (Phoenix, Arizona); Dong-Kyun Seo (Chandler, Arizona); Sand Aldagari (Tempe, Arizona); Masoumeh Mousavi (Tempe, Arizona) |
| ABSTRACT | A bitumen composite includes an amine-impregnated zeolite and bitumen. Forming the bitumen composite includes combining bitumen and an amine-impregnated zeolite to yield a mixture, heating the mixture to yield the bitumen composite. |
| FILED | Wednesday, August 16, 2023 |
| APPL NO | 18/450535 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 39/026 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/203 (20130101) C08J 2395/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) C08K 9/12 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 95/00 (20130101) C08L 2555/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084315 | Hittinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chris Todd Hittinger (Madison, Wisconsin); EmilyClare Patricia Baker (Madison, Wisconsin) |
| ABSTRACT | Polypeptides comprising maltose/maltotriose transporters are provided. Additionally, polynucleotides, DNA constructs, and vectors encoding a maltose/maltotriose transporter, or yeast cells harboring such polynucleotides are provided. The yeast cell may be a Saccharomyces eubayanus cell modified to increase the expression or transport activity of a maltose/maltotriose transporter at the plasma membrane of the cell. Further, methods are provided for making a fermentation product by culturing any one of the yeast cells described herein with a fermentable substrate. Finally, methods are provided to select for and isolate maltotriose-utilizing strains of Saccharomyces eubayanus. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/340527 |
| CURRENT CPC | Peptides C07K 14/395 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 15/81 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084360 | Ismagilov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. Ismagilov (Altadena, California); Natalie Wu-Woods (Pasadena, California); Jacob T. Barlow (Cambridge, Massachusetts); Anna E. Romano (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems to selectively deplete a biological sample of host compartments and/or host nucleic acid while enriching the sample microbial compartments and/or related microbial nucleic acid. In addition, provided herein are compositions, methods and systems related to said host depletion and microbial enrichment methods and systems. |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/351461 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084481 | YI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyunmin YI (Lexington, Massachusetts); Maurice Bukenya (Medford, Massachusetts); Subhash Kalidindi (Arlington, Massachusetts) |
| ABSTRACT | Disclosed is a method for producing a micropatterned opal hydrogel film comprising an evaporation-polymerization method. The method provides a simple and inexpensive fabrication method to produce micropatterned opal hydrogel films. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 18/271135 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) B82Y 30/00 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 5/00 (20130101) C30B 29/58 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084561 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiong Yu (Beachwood, Ohio); Xudong Fan (Cleveland, Ohio) |
| ABSTRACT | In a described example, a system for leak detection and localization is provided. The system includes a water distribution network (WDN) partition stage programmed to cluster a WDN model into partition zones based on applying a modified k-means clustering algorithm to leakage characteristic data and physical connectivity data. A leakage monitoring stage can be programmed to detect the occurrence of leakage in the WDN and provide leak detection data based on applying a trained unsupervised leakage detection machine-learning model to the partition zones and sensor data. The leakage monitoring stage can also provide localization data to identify a location of a leakage zone in the WDN based on feeding the leak detection data to a localization machine-learning model. |
| FILED | Monday, August 28, 2023 |
| APPL NO | 18/456958 |
| CURRENT CPC | Installations or Methods for Obtaining, Collecting, or Distributing Water E03B 7/003 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) G06N 3/0455 (20230101) G06N 3/0464 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085416 | VAN DER HORST et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); UNIVERSITY OF CAPE TOWN (Cape Town, South Africa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Megan VAN DER HORST (Nashville, Tennessee); David WRIGHT (Nashville, Tennessee); Jonathan M. BLACKBURN (Cape Town, South Africa); Leshern KARAMCHAND (Cape Town, South Africa) |
| ABSTRACT | The present disclosure is directed to the use of microvirin-N in the detection of Mycobacterium tuberculosis infections. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 18/253755 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5695 (20130101) Original (OR) Class G01N 2333/35 (20130101) G01N 2405/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085441 | ROLLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachel Marie ROLLER (South Bend, Indiana); Marya LIEBERMAN (South Bend, Indiana) |
| ABSTRACT | A paper analytical device for detecting an analyte in a sample, and methods of fabricating and using the same. A paper analytical device may include laminated strips of a porous hydrophilic substrate and an adhesive layer. The laminated strips may be disposed on a hydrophobic backing with an air gap barrier between each laminated strip that is about 1 mm to about 5 mm in width and extends along the entire length of the laminated strip. A paper analytical device also may include one or more assay regions having one or more reagents for detecting an analyte, and sample deposition areas for receiving a test sample. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/453116 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 2200/12 (20130101) B01L 2200/16 (20130101) B01L 2300/021 (20130101) B01L 2300/069 (20130101) B01L 2300/0681 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085597 | Sonwalkar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SunDensity, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nishikant Sonwalkar (Boston, Massachusetts) |
| ABSTRACT | A photonic surface has a thin film layer having an array of nano-holes formed within a material, wherein the nano-holes are uniformly dimensioned and distributed to enhance plasmonic response of the material over a range of wavelengths. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/463452 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) Original (OR) Class G02B 27/0012 (20130101) G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085670 | SUN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheng SUN (Evanston, Illinois); Rihan HAI (Evanston, Illinois); Henry Oliver Tenadooah WARE (Evanston, Illinois); Evan Hunter JONES (Evanston, Illinois) |
| ABSTRACT | Provided herein are methods of making imaging systems. In one aspect, the method may comprise providing a lens; providing an optomechanical assembly; providing an imaging sensor; and operably connecting the optomechanical assembly with said lens and said imaging sensor, forming said imaging system. In some aspects, providing an optomechanical assembly may comprise manufacturing a component of the optomechanical assembly using additive manufacturing. In some aspects, providing an optomechanical assembly may comprise manufacturing a component of the optomechanical assembly using micro-continuous liquid interface production (μCLIP) 3D printing. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/367349 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00 (20130101) Optical Elements, Systems, or Apparatus G02B 7/003 (20130101) G02B 7/006 (20130101) G02B 7/022 (20130101) G02B 7/026 (20130101) G02B 13/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240086554 | Daughety et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); The United States of America as represented by the Secretary of the Air Force (JBSA-Lackland, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Daughety (Pleasant Plain, Ohio); Marcus Pendleton (San Antonio, Texas); Shouhuai Xu (Colorado Springs, Colorado); Laurent L. Njilla (Liverpool, New York); Tyler Reuther (San Antonio, Texas) |
| ABSTRACT | A cross-domain solution architecture includes a higher-security domain and a lower-security domain. The higher-security domain (i) processes data on a higher-security level, and (ii) includes a hardware-based trusted executed environment (TEE) running a formally verified microkernel. The lower-security domain (i) processes data on a lower-security level having lower security than the higher-security level, and (ii) includes a trusted computer base (TCB). The TCB operates in the higher-security domain and the lower-security domain to pass data from the lower-security domain to the higher-security domain through a first data diode, and to pass data from the higher-security domain to the lower-security domain through a second data diode. |
| FILED | Saturday, April 22, 2023 |
| APPL NO | 18/138053 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/604 (20130101) Original (OR) Class G06F 2221/2113 (20130101) G06F 2221/2141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240087678 | Kuchroo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manik Kuchroo (New Haven, Connecticut); Smita Krishnaswamy (New Haven, Connecticut) |
| ABSTRACT | The present invention describes a CATCH assay for detecting cellular populations, biomarkers or biological interactions in a sample, and methods of use of the assay for identifying novel biomarkers of diseases and disorders and for diagnosing or treating diseases and disorders. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465301 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) Original (OR) Class G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088283 | Minnich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Austin Minnich (San Marino, California); Iretomiwa Esho (Pasadena, California); Bekari Gabritchidze (Pasadena, California); Kieran A. Cleary (Pasadena, California) |
| ABSTRACT | A high electron mobility transistor (HEMT) including a channel; a barrier confining mobile charge carriers in the channel; a drain contact to the channel; a source contact to the channel; and a gate contact coupled to the channel and modulating a current, comprising the mobile charge carriers flowing in response to a voltage VSD applied between the source contact and the drain contact, when an RF signal electric field and DC bias electric field are applied between the gate contact and the source contact. An offset between the conduction bands of the channel and barrier is increased to a level that suppresses real space transfer noise associated with a portion of the mobile charge carriers being thermionically emitted out of the channel into the barrier when the VSD is applied, wherein the RST noise is reduced by at least a factor of two as compared to a HEMT where the alloy composition of the barrier is lattice matched. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465902 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/088 (20130101) H01L 29/0865 (20130101) H01L 29/0882 (20130101) H01L 29/2003 (20130101) H01L 29/7783 (20130101) H01L 29/7786 (20130101) Original (OR) Class H01L 29/66431 (20130101) H01L 29/66462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088430 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan); WAYNE STATE UNIVERSITY (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan); WAYNE STATE UNIVERSITY (Detroit, Michigan) |
| INVENTOR(S) | Fan XU (Oakland Township, Michigan); Robert D. SCHMIDT (Bloomfield Hills, Michigan); Mei CAI (Bloomfield Hills, Michigan); Manuela Ferreira BORRAS (Dearborn, Michigan); Yingxi Elaine ZHU (Troy, Michigan) |
| ABSTRACT | A hybrid solid-state electrolyte layer for use in an electrochemical cell is provided. The hybrid solid-state electrolyte layer includes a polymeric material, a ceramic material, and an interfacial material adhering the polymeric material and the ceramic material. The interfacial material includes a branched copolymer that includes dopamine and a second monomer. The second monomer forms a polymeric moiety in the copolymer that is the same or similar to the polymeric material. In certain variations, the polymeric material defines a polymeric layer, the ceramic material defines a ceramic layer, and the interfacial material defines an interfacial layer that is disposed between the polymeric layer and the ceramic layer. In other variations, the polymeric material defines a polymeric matrix, the ceramic material defines a plurality of ceramic particles dispersed in the polymeric matrix, and the plurality of ceramic particles are coated with the interfacial material. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896821 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/056 (20130101) Original (OR) Class H01M 2300/0071 (20130101) H01M 2300/0082 (20130101) H01M 2300/0097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240090244 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); William A. Gaviria Rojas (Mountain View, California); Megan E. Beck (Hillsboro, Oregon); Vinod K. Sangwan (Evanston, Illinois) |
| ABSTRACT | One aspect of this invention relates to an ohmic-contact-gated transistor (OCGT), comprising a bottom gate electrode formed on a substrate; a first dielectric layer formed on the bottom gate electrode; a thin film formed of a semiconducting material on the first dielectric layer; a bottom contact formed on a part of the thin film; a second dielectric layer conformally grown on the bottom contact to result in a self-aligned dielectric extension from the bottom contact on the thin film; and a top contact formed on the second dielectric layer on the top of the bottom contact and fully overlapping with the dielectric extension to define a device channel in the thin film under the dielectric extension between the bottom contact and the top contact. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 18/270891 |
| CURRENT CPC | Organic electric solid-state devices H10K 10/84 (20230201) Original (OR) Class H10K 10/476 (20230201) H10K 85/221 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240090345 | Huang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiang Huang (Tuscaloosa, Alabama) |
| ABSTRACT | A carrier is provided for quantum computer chips that allows easy implementation, connection, and communication to and from the quantum computer chips while minimizing the thermal perturbation and avoiding labor intensive manual connection as well as the human error in such manual connection. Methods for fabricating such carriers are also provided. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/483924 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 12/14 (20130101) Electric solid-state devices not otherwise provided for H10N 60/01 (20230201) Original (OR) Class H10N 60/82 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240082779 | PYRZYNSKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GTI ENERGY (DES PLAINES, Illinois) |
| ASSIGNEE(S) | GTI ENERGY (DES PLAINES, Illinois) |
| INVENTOR(S) | Travis PYRZYNSKI (Rockford, Illinois); Guillermo CHAQUINGA NAVARRO (Doral, Florida); Sanad SAWAKED (Hoffman Estates, Illinois); Osman AKPOLAT (Northbrook, Illinois) |
| ABSTRACT | A system and method for optimizing operation of a rotating packed bed desorber or regenerator wherein a rich solvent is input and CO2 product and lean solvent are output includes collecting condensed water from a regeneration section of a rotating packed bed desorber system. The collected condensed water is then repressurized and reheated to generate steam and the steam is injected into the rotating packed bed desorber or regenerator as stripping vapors while heating rich solvent. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/244673 |
| CURRENT CPC | Separation B01D 53/1425 (20130101) B01D 53/1431 (20130101) Original (OR) Class B01D 2257/504 (20130101) B01D 2259/401 (20130101) B01D 2259/40088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082823 | Jang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gyoung Gug Jang (Knoxville, Tennessee); Radu Custelcean (Knoxville, Tennessee); Xin Sun (Knoxville, Tennessee); Constantinos Tsouris (Oak Ridge, Tennessee) |
| ABSTRACT | A method for regenerating an amine-containing sorbent material useful in CO2 capture, the method comprising exposing an amine-containing sorbent-CO2 complex to microwave radiation to result in release of CO2 and regenerated amine-containing sorbent that is uncomplexed with CO2, wherein the amine-containing sorbent-CO2 complex contains either: (i) a carbamate bond; or (ii) an ion pair bond of the formula wherein Ra, Rb, and Rc are selected from H and hydrocarbon groups containing at least one carbon atom, wherein at least one of Ra, Rb, and Rc is H; Xm− is a carbonate or bicarbonate anion, with m being 1 for bicarbonate and 2 for carbonate; and n is an integer of 1 or 2, provided that n×m=2. The method may also include re-using the regenerated amine-containing sorbent to capture carbon dioxide. |
| FILED | Thursday, August 17, 2023 |
| APPL NO | 18/235081 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/22 (20130101) B01J 20/3441 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082896 | Komarasamy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mageshwari Komarasamy (Richland, Washington); Scott A. Whalen (West Richland, Washington); Glenn J. Grant (Benton City, Washington); Brandon Scott Taysom (West Richland, Washington) |
| ABSTRACT | A method for solid phase processing (SPP) of a feedstock is provided. The method can include providing relative rotation and translation between an extrusion die and a feedstock, where the die has an extrusion aperture through which a tapered mandrel extends. A first and second extrudate portions can each be generated via the aperture. An axial position of the tapered mandrel can be adjusted relative to the die face during the rotation and translation such that a second extrudate portion is generated having a different inner dimension compared to the first portion, thereby varying a wall thickness between portions. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/513392 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/001 (20130101) B21C 23/01 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082898 | Taysom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon Scott Taysom (West Richland, Washington); Scott A. Whalen (West Richland, Washington) |
| ABSTRACT | An extrusion system can establish or adjust a position of a tapered, rotationally fixed mandrel with respect to a die orifice to adjustably establish or vary an extrusion aperture width therebetween. This, in turn, can adjustably establish or vary a wall thickness of a tubular extrusion product formed by the extrusion. A die tool can provide rotational shear force and axial compression force to plasticize a billet material for extrusion. The rotationally fixed mandrel can include a lateral outer dimension that varies along a longitudinal direction to vary an inner boundary of the extrusion aperture in response to movement of the rotationally fixed mandrel with respect to the die tool along the central longitudinal axis. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/244814 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/085 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/13 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083067 | HU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liangbing HU (Rockville, Maryland); Yu LIU (Berwyn Heights, Maryland) |
| ABSTRACT | A piece of natural fibrous plant material, such as wood or bamboo, can be infiltrated with a chemical solution and subsequently subjected to a temperature of at least 80° C. to produce a softened piece of fibrous plant material having modified lignin therein. The content of modified lignin in the softened piece can be at least 90% of the content of native lignin in the natural fibrous plant material. The modified lignin retained in the softened piece can have shorter macromolecular chains than that of the native lignin. The softened piece can be subjected to densification, for example, to yield a high-strength structural material, or to subsequent drying, for example, to yield a flexible or anisotropically-clastic material. The processing of the natural fibrous plant material can avoid, or at least reduce, the production of black liquor or other waste liquids. |
| FILED | Saturday, August 27, 2022 |
| APPL NO | 18/274393 |
| CURRENT CPC | Processes, Apparatus or Selection of Substances for Impregnating, Staining, Dyeing, Bleaching of Wood or Similar Materials, or Treating of Wood or Similar Materials With Permeant Liquids, Not Otherwise Provided for; Chemical or Physical Treatment of Cork, Cane, Reed, Straw or Similar Materials B27K 3/08 (20130101) B27K 3/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083819 | BENCK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sublime Systems, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | Sublime Systems, Inc. (Somerville, Massachusetts) |
| INVENTOR(S) | Jesse D. BENCK (Wakefield, Massachusetts); Yet-Ming CHIANG (Weston, Massachusetts); Kyle DOMINGUEZ (Boston, Massachusetts); Leah D. ELLIS (Somerville, Massachusetts); Khashayar JAFARI (Melrose, Massachusetts); Mariya LAYUROVA (Cambridge, Massachusetts); Ada MACLEOD (Sherborn, Massachusetts) |
| ABSTRACT | Various embodiments include cementitious compositions with low levels of embodied greenhouse gas emissions, in particular carbon dioxide, as a result of its production and/or use compared to conventional cementitious materials, such as portland cement. Various embodiments include any cementitious material or materials with low embodied carbon, as well as any material produced using this cement. |
| FILED | Tuesday, November 21, 2023 |
| APPL NO | 18/516399 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 7/12 (20130101) C04B 28/188 (20130101) Original (OR) Class C04B 2111/00637 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240083954 | Kong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leopold Kong (Bethesda, Maryland); Ian A. Wilson (La Jolla, California); Natalia de Val (San Diego, California); Andrew B. Ward (San Diego, California); Dennis Burton (La Jolla, California); Linling He (San Diego, California); Jiang Zhu (San Diego, California) |
| ABSTRACT | The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections. |
| FILED | Tuesday, August 15, 2023 |
| APPL NO | 18/449739 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 47/6929 (20170801) Peptides C07K 14/005 (20130101) C07K 14/162 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084315 | Hittinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chris Todd Hittinger (Madison, Wisconsin); EmilyClare Patricia Baker (Madison, Wisconsin) |
| ABSTRACT | Polypeptides comprising maltose/maltotriose transporters are provided. Additionally, polynucleotides, DNA constructs, and vectors encoding a maltose/maltotriose transporter, or yeast cells harboring such polynucleotides are provided. The yeast cell may be a Saccharomyces eubayanus cell modified to increase the expression or transport activity of a maltose/maltotriose transporter at the plasma membrane of the cell. Further, methods are provided for making a fermentation product by culturing any one of the yeast cells described herein with a fermentable substrate. Finally, methods are provided to select for and isolate maltotriose-utilizing strains of Saccharomyces eubayanus. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/340527 |
| CURRENT CPC | Peptides C07K 14/395 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 15/81 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084479 | SCHULTE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Louis SCHULTE (Denver, Colorado); John David SIMON (Austin, Texas); Aaron Joseph PTAK (Littleton, Colorado) |
| ABSTRACT | Described herein are devices and methods related to compositionally graded buffers (CGB) and methods and/or systems for producing CGBs. CGBs enable the growth of high quality materials that are lattice mismatched to a substrate. More specifically, the present disclosure relates to methods for making CGBs by hydride vapor phase epitaxy (HVPE). HVPE methods using a single chamber for producing a CGB may result in a transience in the CGB layers as the flows supplying the reactants are switched to produce the next subsequent layer in the CGB. In contrast to this static style of grading, the present disclosure describes a dynamic method for producing CGBs, in which multiple growth chambers are utilized. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 18/261893 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/16 (20130101) C30B 25/183 (20130101) Original (OR) Class C30B 29/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085012 | Narendran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nadarajah Narendran (Clifton Park, New York); Jean Paul Freyssinier (Troy, New York); Ukwatte Lokuliyanage Indika Perera (Clifton Park, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Nadarajah Narendran (Clifton Park, New York); Jean Paul Freyssinier (Troy, New York); Ukwatte Lokuliyanage Indika Perera (Clifton Park, New York) |
| ABSTRACT | One embodiment provides a luminaire. The luminaire includes a light transfer structure, and a thermal management structure. The light transfer structure is configured to receive light from at least one light emitting diode (LED). The thermal management structure is configured to manage a thermal energy of the at least one LED. The light transfer structure and the thermal management structure are formed during a same three-dimensional (3D) printing process. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 18/273100 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Functional Features or Details of Lighting Devices or Systems Thereof; Structural Combinations of Lighting Devices With Other Articles, Not Otherwise Provided for F21V 29/83 (20150115) Original (OR) Class F21V 29/503 (20150115) Indexing Scheme Associated With Subclasses F21K, F21L, F21S and F21V, Relating to the Form or the Kind of the Light Sources or of the Colour of the Light Emitted F21Y 2115/10 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085330 | Demos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| ASSIGNEE(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| INVENTOR(S) | Stavros G. Demos (Pittsford, New York); Chi Huang (Foster City, California) |
| ABSTRACT | Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limitation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments. Although just the tissue auto fluorescence maybe used, image quality is enhanced with brief application of nontoxic fluorescent dyes to selectively highlight cellular compartments. Sample preparation is safe, efficient and familiar to students with basic chemistry or biology lab experience. Mixed-dye powders may be used to simplify translation of this method for educational, medical, research, low resource, and other settings. |
| FILED | Tuesday, November 21, 2023 |
| APPL NO | 18/515408 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 21/6458 (20130101) Original (OR) Class G01N 2001/302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085884 | Henzl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRIAD National Security, LLC. (Los Alamos, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vlad Henzl (Los Alamos, New Mexico); Rollin Evan Lakis (Los Alamos, New Mexico); Emily Stark Teti (Los Alamos, New Mexico) |
| ABSTRACT | A system includes a plurality of non-intrusive sensors, an access point device, and a computing device. The non-intrusive sensors are configured to monitor activities associated with one or more devices, wherein at least one non-intrusive sensor of the plurality of non-intrusive sensors is positioned within a physical vicinity of the one or more devices. The access point device is communicatively coupled to the plurality of non-intrusive sensors, wherein the access point device is configured to receive data associated with the monitored activities from the plurality of non-intrusive sensors and further to transmit the data associated with the monitored activities to a computing device for processing. The computing device is configured to receive the data associated with the monitored activities and process the data to determine an anomaly associated with the one or more devices. |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/243564 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4155 (20130101) Original (OR) Class G05B 2219/32404 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1425 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240086315 | Roberts |
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| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Roberts (Wellesley, Massachusetts) |
| ABSTRACT | Systems, apparatuses, and methods related to memory access statistics monitoring are described. A host is configured to map pages of memory for applications to a number of memory devices coupled thereto. A first memory device comprises a monitoring component configured to monitor access statistics of pages of memory mapped to the first memory device. A second memory device does not include a monitoring component capable of monitoring access statistics of pages of memory mapped thereto. The host is configured to map a portion of pages of memory for an application to the first memory device in order to obtain access statistics corresponding to the portion of pages of memory upon execution of the application despite there being space available on the second memory device and adjust mappings of the pages of memory for the application based on the obtained access statistics corresponding to the portion of pages. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/512850 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0238 (20130101) Original (OR) Class G06F 12/0292 (20130101) G06F 12/0882 (20130101) G06F 13/1621 (20130101) G06F 13/1689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240086588 | Gering |
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| FUNDED BY |
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| APPLICANT(S) | BATTELLE ENERGY ALLIANCE, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | BATTELLE ENERGY ALLIANCE, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Kevin L. Gering (Idaho Falls, Idaho) |
| ABSTRACT | An energy storage device (ESD) manager may be configured to utilize and/or develop aging models configured to model age-related performance degradation predicted to be incurred by an ESD under respective operating conditions. The aging model of an ESD may be used to determine operating conditions that satisfy the performance and/or endurance requirements of an application. The ESD manager may generate a policy to manage operation of the ESD in accordance with the determined operating conditions. For example, the aging model may be used to determine discharge conditions predicted to ensure that performance degradation incurred by the ESD remains below a threshold for a specified usage period. The discharge conditions may be used to determine a discharge configuration adapted to configure the application to utilize the ESD in accordance with the determined discharge conditions. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/504028 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240086598 | Rackauckas et al. |
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| FUNDED BY |
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| APPLICANT(S) | JuliaHub, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Rackauckas (Cambridge, Massachusetts); Viral B. Shah (Cambridge, Massachusetts) |
| ABSTRACT | Methods and computer systems for transforming a model of a first scientific computing language to a model (e.g., surrogate) of a second scientific computing language such that the surrogate is trained across a plurality of possible inputs is disclosed. Model inputs in a first scientific computing language are received. A surrogate is generated based on the received model input. The surrogate may be trained across a plurality of possible inputs by selecting an input function representation for the model input, selecting a parameter space, sampling the parameter space to generate a training set of time series for each parameter set, simulating a reservoir, computing projections from the simulated reservoir, and fitting an interpolating function between the projections to establish an approximate projection for unknown input functions and parameter values. The surrogate is then deployed, either trained or untrained depending on the embodiment. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505733 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/27 (20200101) Original (OR) Class G06F 40/47 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240087762 | Okuniewski et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria A. Okuniewski (West Lafayette, Indiana); Dulus Owen (New London, Connecticut) |
| ABSTRACT | An in-situ creep capsule for a nuclear reactor, and methods of using. The capsule has a modular design which allows it to be used to test multiple different types and sizes of specimens and to be adapted for use in various different nuclear reactor configurations. The capsule may include an integrated heat exchanger to cool measuring instrumentation, which allows the capsule to be used for gathering data in-situ in next generation reactors with higher temperatures while the reactor is running. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465510 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/2291 (20130101) Nuclear Reactors G21C 17/10 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088259 | TELLEKAMP, Jr. et al. |
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| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marshall Brooks TELLEKAMP, Jr. (Denver, Colorado); MVS CHANDRASHEKHAR (Columbia, South Carolina) |
| ABSTRACT | Described herein are systems and methods for the facile growth of aluminum gallium nitride semiconductor devices by utilizing specific lattice matched substrates. These substrates include metal borides, for example, ScB2, HfB2 and ZrB2 and metal carbides and metal nitrides. These substrates may allow for the cost effective manufacturing of ultra-wide bandgap semiconductor devices. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/464761 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/02425 (20130101) H01L 29/045 (20130101) H01L 29/66431 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088314 | FLICK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Austin FLICK (Stanford, California); Reinhold H. DAUSKARDT (Menlo Park, California) |
| ABSTRACT | A vertically selective liftoff scribing process is provided. One application is the fabrication of solar cells and solar modules. The basis of this technology is absorption of an indirectly focused laser beam in the front electrode material of the device, which enables removal of this layer (e.g., a P1 scribe) or removal of layers above the front electrode while leaving the front electrode intact (e.g., a P2 or P3 scribe). The laser fluence can be selected to choose between these alternatives, and further fine tuning is possible depending on details of the device structure. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/244767 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/40 (20130101) B23K 26/0624 (20151001) B23K 2103/172 (20180801) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0463 (20141201) Original (OR) Class H01L 31/0512 (20130101) H01L 31/022425 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088382 | Xiao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Jie Xiao (Richland, Washington); Yujing Bi (Richland, Washington) |
| ABSTRACT | Methods for synthesizing single crystalline Ni-rich cathode materials are disclosed. The Ni-rich cathode material may have a formula LiNixMnyMzCol1-x-y-zO2, where M represents one or more dopant metals, x≥0.6, 0.01≤y<0.2, 0≤z≤0.05, and x+y+z≤1.0. The methods are cost-effective, and include methods for solid-state, molten-salt, and flash-sintering syntheses. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/514508 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/50 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/85 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088402 | Evans et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Phillips 66 Company (Houston, Texas); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Conor Evans (Harvest, Alabama); Meilin Liu (Alpharetta, Georgia); Ying Liu (Bartlesville, Oklahoma); Yucun Zhou (Atlanta, Georgia) |
| ABSTRACT | A solid oxide cell (SOC) includes a fuel electrode, an oxygen electrode, and an electrolyte. In some embodiments, the solid oxide cell is a reversible proton conducting solid oxide cell (P-rSOC). In some embodiments, the oxygen electrode is a perovskite oxide material having a formula such as PrBa0.8Ca0.2Co2O5+δ, PrBa0.9Co1.96Nb0.04O5, PrBaCo1.6Fc0.2Nb0.2−xO5+δ, PrBa0.5Sr0.5Co1.5Fe0.5O5+δ (PBSCF), or PrBaCo2O5+δ (PBC) and it is coated with a perovskite oxide catalyst such as PrCoO3. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/346038 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9033 (20130101) Original (OR) Class H01M 8/186 (20130101) H01M 8/0656 (20130101) H01M 8/1213 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088433 | Visco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | PolyPlus Battery Company (Berkeley, California) |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California); Vitaliy Nimon (San Francisco, California) |
| ABSTRACT | A lithium ion-conductive solid electrolyte including a freestanding inorganic vitreous sheet of sulfide-based lithium ion conducting glass is capable of high performance in a lithium metal battery. Such an electrolyte is also manufacturable, and readily adaptable for battery cell and cell component manufacture, in a cost-effective, scalable manner using an automated machine based system, apparatus and methods based on inline spectrophotometry to assess and inspect the quality of such vitreous solid electrolyte sheets and associated components. Suitable manufacturing methods can involve providing a sulfur precursor, providing a boron precursor material having lithium as a second constituent, combining the sulfur and boron precursor materials to form a precursor mixture, melting the mixture, and cooling the melt to form a solid lithium ion conducting glass. The glass may have a Li+ conductivity of at least 10−5 S/cm. The boron precursor material may be synthesized by reducing boron oxide to boron metal by heating the boron oxide in direct contact with lithium metal. |
| FILED | Monday, July 10, 2023 |
| APPL NO | 18/349770 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 50/406 (20210101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088461 | Mueller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Mueller (Albuquerque, New Mexico); Yuliya Preger (Albuquerque, New Mexico); John C. Hewson (Albuquerque, New Mexico); Andrew Kurzawski (Austin, Texas) |
| ABSTRACT | A method and system for dispersing stored energy in an energy storage system to delay or arrest propagation of thermal runaway and thermally-induced cascading failures. The system includes a plurality of battery sub-assemblies and DC-DC converters connected to a shared DC bus through which energy may be exchanged. The system may be interfaced to an AC power grid or DC power system through an additional power converter. The method of dispersing stored energy uses this system to charge and discharge sub-assemblies such that the system is less susceptible to propagation of thermal runaway. The method determines, based on awareness of current system state, battery types, and electrical and thermal structure, the sequence of charging and discharging actions to best inhibit thermal runaway while preserving the system's ability to perform subsequent energy redistribution. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511380 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/425 (20130101) H01M 10/441 (20130101) H01M 10/443 (20130101) Original (OR) Class H01M 10/482 (20130101) H01M 2010/4271 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/007 (20130101) H02J 2207/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088467 | Liao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Princeton NuEnergy Inc. (Bordentown, New Jersey) |
| ASSIGNEE(S) | Princeton NuEnergy Inc. (Bordentown, New Jersey) |
| INVENTOR(S) | Jinyun Liao (Yardley, Pennsylvania); Zhiqian Wang (Florence, New Jersey); Chao Yan (Princeton, New Jersey); Xiaofang Yang (Ambler, Pennsylvania) |
| ABSTRACT | One or more aspects of the present disclosure provide methods for discharging spent batteries. The methods may include coating anode electrodes and cathode electrodes of the spent batteries with at least one catalyst layer. The catalyst layer may facilitate consistent and rapid discharge of the spent batteries. The spent batteries may be processed using an electrolyte solution to discharge the spent batteries. The electrolyte solution may include one or more suitable electrolytes that do not cause electrode corrosion during the discharge of the spent batteries. For example, the electrolytes may include a mixture of Na3PO4, water, co-solvent (e.g., ethylene glycol), and at least one surfactant, such as polyoxymethylene glycol octylphenol ethers, dioctyl sodium sulfosuccinate, perfluorooctanesulfonate, etc. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/464634 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0407 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/399 (20130101) H01M 2300/0022 (20130101) H01M 2300/0028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088800 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Boran Fan (Blacksburg, Virginia); Dushan Boroyevich (Blacksburg, Virginia); Rolando Burgos (Blacksburg, Virginia); Jayesh Kumar Motwani (Blacksburg, Virginia); Jun Wang (Lincoln, Nebraska) |
| ABSTRACT | Aspects of switching-cycle voltage deviation control for modular multilevel converters (MMCs) are described. In one example, an upper switching action of an upper power cell is determined within a time duration of a switching cycle for an MMC. In addition, a lower switching action of a lower power cell is determined within the time duration of the switching cycle for the MMC. In addition, a delay is generated between the upper switching action and the lower switching action to reduce capacitor voltage deviation between the upper power cell and the lower power cell during the switching cycle. The upper power cell is located in an upper arm of a phase leg of the MMC, while the lower power cell is located in a lower arm of the phase leg of the MMC. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/932079 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/0043 (20210501) H02M 7/4835 (20210501) Original (OR) Class H02M 7/5395 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240089001 | Schow et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Clint Schow (Santa Barbara, California); James Buckwalter (Santa Barbara, California); Aaron Maharry (Goleta, California); Hector Andrade (Goleta, California); Larry Coldren (Santa Barbara, California) |
| ABSTRACT | Systems and methods for fabricating an optoelectronic transceiver with a tunable traveling wave modulator and an analog coherent receiver to transmit and receive wavelength-multiplexed optical signals in accordance with embodiments of the invention are disclosed. In one embodiment, a network switch includes a plurality of ports configured to transmit and receive optical signals and electrical current signals, a plurality of optoelectronic transmitters using a traveling wave modulator and driver biasing, and a plurality of analog coherent receivers. |
| FILED | Wednesday, September 13, 2023 |
| APPL NO | 18/466608 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0136 (20130101) G02F 1/212 (20210101) G02F 3/00 (20130101) G02F 2201/02 (20130101) G02F 2203/50 (20130101) Transmission H04B 10/40 (20130101) Original (OR) Class H04B 10/61 (20130101) H04B 10/516 (20130101) Multiplex Communication H04J 14/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240089284 | Rieger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battle Energy Alliance, LLC. (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig G. Rieger (Pocatello, Idaho); Konstantinos Kolias (Idaho Falls, Idaho); Robert Christopher Ivans (Ammon, Idaho) |
| ABSTRACT | A system comprises one or more networks including a digital twin and one or more cyber system components. The digital twin is configured to emulate at least a portion of a physical system of an operational technology (OT) system. One or more processors of the system are configured to select a mitigative response measure to enable in the one or more networks for execution in response to a simulated cyber attack; determine a physical system reaction and a cyber system reaction responsive to the simulated cyber attack and the mitigative response measure; and determine a resilience level of an OT system enabled with the mitigative response measure responsive to the physical system reaction and the cyber system reaction. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465852 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1433 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240081289 | Kraayenbrink et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Ann Kraayenbrink (Ames, Iowa); Anna Butters-Johnson (Ames, Iowa); Derek Kraayenbrink (Ames, Iowa) |
| ABSTRACT | An apparatus, systems, and methods of providing enrichment to poultry during raising or maintaining of the poultry. One or more light sources project beams to generate laser spots at and around the poultry. A control regimen moves the light spots relative the poultry in generally random fashion during timed sessions for each given time period (e.g. each day). The spot movement is designed to promote benefits to poultry and producer in correlation to experimental data related to animal welfare, health, and commercial value. |
| FILED | Thursday, August 17, 2023 |
| APPL NO | 18/451569 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 15/027 (20130101) Original (OR) Class A01K 39/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240081368 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yonghui LI (Manhattan, Kansas); Yanting SHEN (Manhattan, Kansas) |
| ABSTRACT | Improved methods for preparing functional food ingredients comprising plant protein, the resulting enhanced functional food ingredients, and foods containing the same. The methods comprise providing a mixture or slurry of plant protein in an aqueous solution, reacting the plant protein with a modification agent selected from the group consisting of an acylating agent, transglutaminase, and protein glutaminase to yield a modified plant protein, and conjugating the modified plant protein with a hydrophilic polysaccharide to yield the functional food ingredient with synergistic improvements in properties. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 18/262961 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/14 (20130101) Original (OR) Class Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/03 (20160801) A23L 29/10 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084207 | Simonpietri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Simonpietri Enterprises LLC (Kailua, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marie-Joelle Simonpietri (Kailua, Hawaii); Zachary Wadas (Kailua, Hawaii) |
| ABSTRACT | Methods and systems for processing construction and demolition (C&D) materials to produce a product gas stream and/or electricity are disclosed herein. In some embodiments, the method comprises pre-processing C&D materials to produce a C&D feed, and processing the C&D feed to produce syngas. The C&D feed can comprise untreated wood, treated wood, paper and cardboard, yard waste, plastic, rubber, and/or foam. Processing the C&D feed can comprise gasifying the C&D feed, steam, and oxygen in a gasifier at a temperature of no more than 950° C. and/or a pressure of no more than 200 psi to produce syngas. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/508119 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/02 (20130101) Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/78 (20130101) Original (OR) Class C10J 2300/092 (20130101) C10J 2300/0946 (20130101) C10J 2300/1696 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084315 | Hittinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chris Todd Hittinger (Madison, Wisconsin); EmilyClare Patricia Baker (Madison, Wisconsin) |
| ABSTRACT | Polypeptides comprising maltose/maltotriose transporters are provided. Additionally, polynucleotides, DNA constructs, and vectors encoding a maltose/maltotriose transporter, or yeast cells harboring such polynucleotides are provided. The yeast cell may be a Saccharomyces eubayanus cell modified to increase the expression or transport activity of a maltose/maltotriose transporter at the plasma membrane of the cell. Further, methods are provided for making a fermentation product by culturing any one of the yeast cells described herein with a fermentable substrate. Finally, methods are provided to select for and isolate maltotriose-utilizing strains of Saccharomyces eubayanus. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/340527 |
| CURRENT CPC | Peptides C07K 14/395 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 15/81 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084325 | Chowdhury |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Shafiqul I. Chowdhury (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | The Boards of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Shafiqul I. Chowdhury (Baton Rouge, Louisiana) |
| ABSTRACT | The invention relates to a Quadruple Gene Deleted Mutant Bovine Herpesvirus Type 1 (BHV-1 QMV) engineered to express protective antigens derived from viruses associated with infection in livestock. The recombinant vector includes a deletion of a cytoplasmic tail of envelope glycoprotein gE (gE-CT), a truncation of glycoprotein gG, a deletion of envelope protein UL49.5 amino acid residues 30-32, and a deletion of UL49.5 cytoplasmic tail amino acid residues 80-96. The truncation of glycoprotein gG comprises a deletion of amino-terminal amino acid residues 1-67. The recombinant vector can include at least two heterologous antigens inserted therein. Included are methods for creating recombinant vectors, mutant viruses, and vaccines for preventing or reducing symptoms associated with viral infection in livestock, in particular bovine respiratory viral infection |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 18/268553 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2710/16734 (20130101) C12N 2710/16743 (20130101) C12N 2710/16762 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240081979 | Kintzing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); The United States Government as represented as The Department of Veterans Affairs (Washington, District of Columbia); Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Kintzing (San Jose, California); Brandon McCutcheon (Rochester, Minnesota); Jayakar V. Nayak (Stanford, California) |
| ABSTRACT | Systems and methods are provided for altering the shape of a target tissue structure of a subject, e.g., a nasal septum or other nasal tissue that include securing a first end of a shaping element to tissue adjacent the structure; manipulating the tissue to alter a shape of the structure; and applying a force to the shaping element to maintain the altered shape of the structure. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/375390 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/186 (20130101) Original (OR) Class A61F 2/2875 (20130101) A61F 2002/2885 (20130101) A61F 2210/0014 (20130101) A61F 2220/0016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240082428 | Goldberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey L. Goldberg (Menlo Park, California); Kun-Che Chang (Redwood City, California) |
| ABSTRACT | Methods and compositions are provided for the treatment of glaucoma and other optic neuropathies. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/271631 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2710/16143 (20130101) C12N 2730/10143 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240087750 | Lo Ciganic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); University of Pittsburgh- Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); University of Pittsburgh- Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Wei Hsuan Lo Ciganic (Gainesville, Florida); Walid Fouad Gellad (Pittsburgh, Pennsylvania) |
| ABSTRACT | h A method for using a trained machine learning model to predict risk of incident opioid use disorder (OUD) and/or of N an opioid overdose episode for a subject. The method comprises using at least one computer hardware processor to perform: accessing data associated with the subject, wherein the data comprises values for a plurality of predictors; generating input features for the trained machine learning model from the data; and providing the input features as input to the trained machine learning model to obtain an output indicative of the risk of OUD and/or of the opioid overdose episode for the subject, wherein the trained machine learning model comprises a first plurality of values for a respective first plurality of parameters, the first plurality of values used by the at least one computer hardware processor to obtain the output from the input features. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 18/010083 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240081893 | Farritor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shane Farritor (Lincoln, Nebraska); Tom Frederick (Gretna, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector. |
| FILED | Wednesday, November 01, 2023 |
| APPL NO | 18/499600 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1445 (20130101) Original (OR) Class A61B 2034/301 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085118 | Margavio et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ThermAvant Technologies LLC (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Margavio (Columbia, Missouri); Scott Hayden (Columbia, Missouri); John Henry Utley (Columbia, Missouri); Alexander Miller (Columbia, Missouri) |
| ABSTRACT | An oscillating heat pipe (OHP) device that comprise a body having a top face, a bottom face and at least one side face, a plurality of hollow OHP channels formed internally within the body, and an oscillating heat pipe (OHP) flushing duct system. The flushing duct system is formed in at least one of a body top face, a bottom face and at least one side face of an OHP device. The flushing duct system fluidly connects one or more of a plurality of OHP channels formed internally within the OHP device to an ambient environment of the device. The flushing duct system comprising at least one welding receptacle. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/463593 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/0275 (20130101) Original (OR) Class F28D 15/0283 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 9/002 (20130101) F28F 2265/22 (20130101) F28F 2275/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240088537 | Deshpande et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manohar Deshpande (Odenton, Maryland); Eleanya Onuma (Springdale, Maryland) |
| ABSTRACT | This application describes an apparatus and system for a Wide band end launcher to convert a signal in a coaxial line to a CPW line. The apparatus uses a transition zone which gradually tapers in two inclined planes from the coaxial line to the CPW line, connecting the central conductor of the coaxial line to the central conductor of the CPW line. In addition, the outer conductor of the coaxial line is connected to the ground plates of the CPW line. This allows for high bandwidth transfers between the two types of lines for accurate measurements and other purposes. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/941250 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/003 (20130101) H01P 3/06 (20130101) H01P 5/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20240084207 | Simonpietri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Simonpietri Enterprises LLC (Kailua, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marie-Joelle Simonpietri (Kailua, Hawaii); Zachary Wadas (Kailua, Hawaii) |
| ABSTRACT | Methods and systems for processing construction and demolition (C&D) materials to produce a product gas stream and/or electricity are disclosed herein. In some embodiments, the method comprises pre-processing C&D materials to produce a C&D feed, and processing the C&D feed to produce syngas. The C&D feed can comprise untreated wood, treated wood, paper and cardboard, yard waste, plastic, rubber, and/or foam. Processing the C&D feed can comprise gasifying the C&D feed, steam, and oxygen in a gasifier at a temperature of no more than 950° C. and/or a pressure of no more than 200 psi to produce syngas. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/508119 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/02 (20130101) Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/78 (20130101) Original (OR) Class C10J 2300/092 (20130101) C10J 2300/0946 (20130101) C10J 2300/1696 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240084371 | Lu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GOVERNMENT OF THE U.S. AS REPRESENTED BY THE ADMINISTOR OF THE U.S. ENVIRONMENTAL PROTECTION AGENCY (Washington, District of Columbia) |
| ASSIGNEE(S) | GOVERNMENT OF THE U.S AS REPRESENTED BY THE ADMINISTOR OF THE U.S. ENVIRONMENTAL PROTECTION AGENCY (WASHINGTON, District of Columbia) |
| INVENTOR(S) | Jingrang Lu (Mason, Ohio) |
| ABSTRACT | A computer system for generating early public warnings and predictions of cyanotoxin production in source water comprised of the a processor for instantiating RT-qPCR test data objects for storing RT-qPCR gene expression data wherein each RT-qPCR test data object is identified by test location, test year. Each RT-qPCR test data object includes one or more multi-dimensional array objects. Each multi-dimensional array object is configured to store ordered sets of data wherein each of said ordered pairs is comprised of measurement dates and a detection value. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/847043 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) G16B 25/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240082899 | SMITH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Keystone Tower Systems, Inc. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric D. SMITH (Denver, Colorado); Rosalind K. TAKATA (Denver, Colorado); Daniel AINGE (Boulder, Colorado); Loren Daniel BRIDGERS (Golden, Colorado) |
| ABSTRACT | Spiral forming methods can be used to join edges of a rolled material along a spiral joint to form conical and/or cylindrical structures. Alignment of the edges of the rolled material can be controlled in a wrapping direction as the material is being joined along the spiral joint to form the structure. By controlling alignment of the edges of the material as the edges of the material are being joined, small corrections can be made over the course of forming the structure facilitating control over geometric tolerances of the resulting spiral formed structure. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/344230 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/12 (20130101) B21C 37/122 (20130101) B21C 37/124 (20130101) B21C 37/128 (20130101) Original (OR) Class B21C 37/185 (20130101) Wind Motors F03D 13/20 (20160501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240085597 | Sonwalkar |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SunDensity, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nishikant Sonwalkar (Boston, Massachusetts) |
| ABSTRACT | A photonic surface has a thin film layer having an array of nano-holes formed within a material, wherein the nano-holes are uniformly dimensioned and distributed to enhance plasmonic response of the material over a range of wavelengths. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/463452 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) Original (OR) Class G02B 27/0012 (20130101) G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240085585 | Remer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | James Henry Remer (Waterford Works, New Jersey) |
| ABSTRACT | Examples are directed toward systems and methods relating to security screening. For example, a screening system includes a sensor array to sense a gravitational field caused by an item, and a conveyor to convey the item through sensing positions for scanning by the sensor array. A controller acquires weight measurement information from sensor elements, and gravitational measurement information from the sensor array. The conveyor incrementally advances the item through additional sensing positions to acquire weight measurement information and gravitational measurement information. The controller performs tomographic reconstruction to generate a tomographic image of the item, using a generated weight map as a static weight input vector and using a generated mass map as a static mass input vector for the tomographic reconstruction. |
| FILED | Friday, November 24, 2023 |
| APPL NO | 18/518866 |
| CURRENT CPC | Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/005 (20130101) Original (OR) Class G01V 7/04 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20240083478 | Liu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiang Liu (New Brunswick, New Jersey) |
| ABSTRACT | Systems and methods enable automated intelligent railway monitoring using railway image data from an imaging device. The railway image data includes image frames produced by the imaging device. A railway object recognition model is used to identify objects within the image frames and a railway condition is determined based on the object. A location and time associated with the railway condition are determined based on railway image data. Railway metrics are generated based on the railway condition and historical railway conditions. A railway condition prediction model is used to predict future railway conditions affecting an operating condition, an operating demand or both based on the railway metrics. An operating recommendation is determined to address the future railway condition and an alert is generated to with an indication of railway condition, the operating recommendation or both. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511330 |
| CURRENT CPC | Guiding Railway Traffic; Ensuring the Safety of Railway Traffic B61L 23/041 (20130101) Original (OR) Class B61L 23/042 (20130101) B61L 25/025 (20130101) B61L 25/026 (20130101) Image Data Processing or Generation, in General G06T 7/0002 (20130101) G06T 7/579 (20170101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30184 (20130101) G06T 2207/30196 (20130101) G06T 2207/30242 (20130101) G06T 2207/30261 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 20/58 (20220101) G06V 40/10 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Treasury (TREASURY)
| US 20240083189 | Rich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WAVEFRONT TECHNOLOGY, INC. (Paramount, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Chapman Rich (Rancho Palos Verdes, California); Joel Mikael Petersen (Valley Village, California); Roger Winston Phillips (Santa Rosa, California); John Michael Tamkin (Pasadena, California) |
| ABSTRACT | A security device includes an array of lenses and a plurality of first and second segments disposed under the array of lenses. At a first viewing angle, the array of lenses presents a first image for viewing without presenting the second image for viewing, and at a second viewing angle different from the first viewing angle, the array of lenses presents for viewing the second image without presenting the first image for viewing. At least one first or second segment can include one or more microstructures or one or more nanostructures configured to produce one or more colors for the first or second image. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/194460 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/08 (20130101) B32B 3/30 (20130101) B32B 7/06 (20130101) B32B 27/08 (20130101) B32B 27/32 (20130101) B32B 27/36 (20130101) B32B 27/285 (20130101) B32B 27/302 (20130101) B32B 27/304 (20130101) B32B 27/365 (20130101) B32B 2307/408 (20130101) B32B 2307/4023 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/21 (20141001) B42D 25/324 (20141001) B42D 25/328 (20141001) B42D 25/351 (20141001) Original (OR) Class B42D 25/373 (20141001) B42D 25/378 (20141001) Special Designs or Pictures B44F 1/045 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0056 (20130101) G02B 27/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
General Services Administration (GSA)
| US 20240089108 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tenet 3, LLC (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelce S. Wilson (Murphy, Texas); Jeff A. Hughes (Dayton, Ohio); Tyler J. Moody (Fairborn, Ohio); Derek E. Doran (Hilliard, Ohio); Gary R. Tuttle (Middletown, Ohio); Joel B. Rieman (Xenia, Ohio) |
| ABSTRACT | A permissioned blockchain, using off-chain storage, provides advantages over blockchains that rely on consensus and/or store information within the blockchain. Advantages include enhanced viability, compactness, and the ability to register material with distribution limitations (e.g., military classified). Examples create an immutable public record of data signatures that confirm when data is intact, without distributing the data itself, so that widespread availability of the blockchain (beyond those privileged to see the data) advantageously increases the size of the community that is able to detect spoofing or forgery attempts. A permissioning entity limits submissions to manage blockchain growth, foreclosing problematic material that may risk long-term viability. Examples render blockchain operations resistant to advanced persistent threats (APTs), leverage digital signatures as additional trust elements for high-risk data, link records to track pedigree and enable identification of superseded (obsolete) data, and leverage out-of-band date proof to enable independent verification of integrity and no-later-than data-of-existence. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/513263 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/64 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/50 (20220501) H04L 9/3218 (20130101) Original (OR) Class H04L 9/3239 (20130101) H04L 9/3247 (20130101) H04L 63/1483 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 20240082858 | Lozano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Paulo C. Lozano (Arlington, Massachusetts); Brian L. Wardle (Lexington, Massachusetts); Michael D. Canonica (Cambridge, Massachusetts); David Krejci (Wartberg, Austria); Yue Zhou (Brookings, South Dakota); Andrew Adams (Chapel Hill, North Carolina) |
| ABSTRACT | Polymeric electro spray emitters and related methods are generally described. In some embodiments, an emitter may be made from an ionic electro active polymer. The composition of the electro spray emitters described herein may enable the transport of ions and/or liquid ion sources, such as an ionic liquid or room temperature molten salt, through the bulk of the polymeric emitter. In some embodiments, the described emitters may be fabricated using a mixture of an ionic electroactive polymer, a solvent, and a liquid ion source to at least partially mitigate swelling effects of the polymer emitter that may otherwise occur when the one or more emitters are exposed to the liquid ion source during operation. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 18/272948 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/0255 (20130101) B05B 5/0533 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240082880 | NAGY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES POSTAL SERVICE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. NAGY (Warrenton, Virginia); Dirk H. SATTLER (Gainesville, Virginia) |
| ABSTRACT | Systems, methods, and devices for designating a location for a delivery item that is being sorted by an operator. The operator scans the delivery address of the item using a particular scanner. Using the delivery address and other information from the scanner that was used, the system determines a sort output location for the item and identifies an indicator device (e.g., an LED device) that corresponds to the sort output location. The system then commands the indicator device to present or display a designator. For example, the indicator device may be commanded to illuminate a light, such as an LED. The operator of the scanner then places the item at the location corresponding to the illuminated light designator. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/514618 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/008 (20130101) B07C 3/14 (20130101) Original (OR) Class B07C 3/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240085242 | BROST |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GEORGE BROST (LEE CENTER, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | GEORGE BROST (LEE CENTER, New York) |
| ABSTRACT | The invention discloses a method which analyzes regression coefficient and spectral consistency in the determination of the accuracy of a calibration for a radiometer. The invention's method simulates the output of a total power radiometer and quantifies the calibration accuracy under various atmospheric conditions. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/125548 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/53 (20220101) G01J 5/804 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, March 14, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240314.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page