FedInvent™ Patent Applications
Application Details for Thursday, March 28, 2024
This page was updated on Tuesday, June 18, 2024 at 02:17 PM GMT
Department of Health and Human Services (HHS)
| US 20240099276 | ZHANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Soochow university (Suzhou, China PRC); Suzhou Industrial Park Center for Disease Control and Prevention (Suzhou, China PRC) |
| ASSIGNEE(S) | Soochow university (Suzhou, China PRC); Suzhou Industrial Park Center for Disease Control and Prevention (Suzhou, China PRC) |
| INVENTOR(S) | Jie ZHANG (Suzhou, China PRC); Jianjun LIU (Suzhou, China PRC); Ouxi SHEN (Suzhou, China PRC); Xiaoyao SONG (Suzhou, China PRC) |
| ABSTRACT | A laboratory zebrafish autism behavioral model apparatus is provided. The laboratory zebrafish autism behavioral model apparatus comprises a model body, wherein the model body is divided into a plurality of experimental units, and each of the experimental units has a cuboid structure with completely identical shapes; a free swimming area, a stimulus area, and a normal non-stimulus area are formed on each of the experimental units; the stimulus area and the normal non-stimulus area are located on two sides of the free swimming area, respectively, and the free swimming area, the stimulus area, and the normal non-stimulus area are interconnected via mesh openings. The zebrafish autism behavioral model apparatus facilitates further exploration of autism etiology, effectively resolving interference between the stimulus area and the zebrafish's innate thigmotactic behavior, reducing experimental errors, saving time, and minimizing instrument wear and costs. |
| FILED | Wednesday, September 20, 2023 |
| APPL NO | 18/370447 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 61/10 (20170101) A01K 63/006 (20130101) Original (OR) Class A01K 2227/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240099277 | Kaczorowski et al. |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| INVENTOR(S) | Catherine Kaczorowski (Bar Harbor, Maine); Sarah M. Neuner (Bar Harbor, Maine); Kristen M.S. O'Connell (Bar Harbor, Maine) |
| ABSTRACT | Provided herein, in some embodiments, are methods for modulating expression and/or activity of transient receptor potential cation channel subfamily C, member 3 (TRPC3), as well as methods of treating Alzheimer's disease. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335598 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) Original (OR) Class A01K 2207/15 (20130101) A01K 2217/15 (20130101) A01K 2217/206 (20130101) A01K 2227/105 (20130101) A01K 2267/0318 (20130101) A01K 2267/0356 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/445 (20130101) A61K 31/713 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240099278 | Flavell et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regeneron Pharmaceuticals, Inc. (Tarrytown, New York); Yale University (New Haven, Connecticut); Institute for Research In Biomedicine (IRB) (Bellinzona, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Flavell (Guilford, Connecticut); Till Strowig (Braunschweig, Germany); Markus G. Manz (Zürich, Switzerland); Chiara Borsotti (Bronxville, New York); Madhav Dhodapkar (New Haven, Connecticut); Andrew J. Murphy (Croton-on-Hudson, New York); Sean Stevens (San Diego, California); George D. Yancopoulos (Yorktown Heights, New York) |
| ABSTRACT | Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/236218 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) A01K 67/0278 (20130101) Original (OR) Class Peptides C07K 14/535 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240099578 | KLIN et al. |
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| APPLICANT(S) | Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia) |
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| INVENTOR(S) | Ami KLIN (Atlanta, Georgia); Warren JONES (Decatur, Georgia) |
| ABSTRACT | Systems, devices, and methods are described for assessing the risk of developmental, cognitive, social, or mental abilities or disabilities in very young patients (e.g., in the first 2-6 months of life). Generally, the decline in visual fixation of a subject over time with respect to certain dynamic stimuli provides a marker of possible abilities or disabilities (such as ASD). The visual fixation of the subject is identified, monitored, and tracked over time through repeated eye tracking sessions, and data relating to the visual fixation is then analyzed to determine a possible increased risk certain conditions in the subject. A change in visual fixation as compared to similar visual fixation data of typically-developing subjects or to a subject's own, prior visual fixation data provides an indication of a developmental, cognitive, or mental ability or disability. |
| FILED | Wednesday, November 29, 2023 |
| APPL NO | 18/523037 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/113 (20130101) Original (OR) Class A61B 5/163 (20170801) A61B 5/167 (20130101) A61B 5/168 (20130101) A61B 2503/04 (20130101) A61B 2503/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240099597 | SRINIVASAN et al. |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
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| INVENTOR(S) | Mandayam A. SRINIVASAN (Newton, Massachusetts); Mohan Thanikachalam (Boston, Massachusetts); Edward Howard Adelson (Winchester, Massachusetts); Abhijit Biswas (Shyamnagar, India) |
| ABSTRACT | A method is directed to continuously, non-invasively, and directly measuring blood pressure, and includes providing a calibrated measurement device having a blood-flow control balloon and a sensor array. The method further includes placing the sensor array in a non-invasive manner over the surface of a patch of skin connected to an artery by adjoining soft tissues and inflating the blood-flow control balloon with a controlled amount of pressure. In response to the inflating of the blood-flow control balloon, changes in the artery geometry and forces are detected, via the sensor array, during a heartbeat cycle. The changes correspond to spatio-temporal signals from the artery or in the adjoining soft tissues. The spatio-temporal signals are measured and processed, via a controller, to determine blood-pressure parameters. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535484 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1075 (20130101) A61B 5/1079 (20130101) A61B 5/02007 (20130101) A61B 5/02233 (20130101) Original (OR) Class A61B 8/0891 (20130101) A61B 2560/0223 (20130101) A61B 2562/04 (20130101) A61B 2562/0214 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240099879 | Diller et al. |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Mercury Biomed, LLC (Cleveland, Ohio) |
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| INVENTOR(S) | Kenneth R. Diller (Elgin, Texas); Sepideh Khoshnevis (Austin, Texas); Brian Patrick (Houston, Texas); Patrick Brown (Cleveland Heights, Ohio) |
| ABSTRACT | A method for regulating a core body temperature of a living subject may include removably coupling a flexible heat exchange pad to a skin surface of the living subject via a flexible adhesive composite laminate, and applying heat via the flexible heat exchange pad to the skin surface and underlying tissue of the living subject while the flexible heat exchange pad is coupled to the skin surface via the flexible adhesive composite laminate such that the applied heat regulates the core body temperature of the living subject. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472362 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/007 (20130101) A61F 7/08 (20130101) Original (OR) Class A61F 2007/0086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240099883 | HUBSCHMAN et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jean Pierre HUBSCHMAN (Los Angeles, California); Matthew J. GERBER (Los Angeles, California); Tsu-Chin TSAO (Los Angeles, California); Jacob ROSEN (Los Angeles, California); Conor McGARTOLL (Los Angeles, California); Zhantao SONG (Los Angeles, California) |
| ABSTRACT | According to certain general aspects, the present embodiments relate generally to a device that mobilizes the lens material inside the capsular bag. Mobilized lens material is easier to visualize than lens material lingering at the lens equator of the eye, or other areas in the capsular bag that are difficult to visualize, making the mobilized lens material easier to retrieve from the capsular bag. Mobilizing the lens material reduces the possibility that the person receiving the cataract surgery will develop secondary cataracts or infections due to lens material left inside the capsular bag. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 18/263520 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 2017/320012 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00736 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240099986 | Rohan |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Lisa Cencia Rohan (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are stable, dissolvable films containing active ingredients, such as antimicrobial composition, antiviral compositions, or anti-retroviral compositions for intravaginal or intrarectal placement to provide prophylaxis against viral infections. |
| FILED | Wednesday, September 13, 2023 |
| APPL NO | 18/367869 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0031 (20130101) A61K 9/0034 (20130101) A61K 9/7007 (20130101) Original (OR) Class A61K 31/505 (20130101) A61K 31/675 (20130101) A61K 47/10 (20130101) A61K 47/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100018 | SCHURDAK et al. |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
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| INVENTOR(S) | Mark E. SCHURDAK (Warrendale, Pennsylvania); Andreas VOGT (Pittsburgh, Pennsylvania); Andrew Michael STERN (Bradenton, Florida); Douglass Lansing TAYLOR (Pittsburgh, Pennsylvania); Fangyuan CHEN (Beijing, China PRC); Fen PEI (Medford, Massachusetts); Hongying CHENG (Pittsburgh, Pennsylvania); Ivet BAHAR (Wexford, Pennsylvania); Qingya SHI (Beijing, China PRC); Moshe ARDITI (Encino, California) |
| ABSTRACT | Disclosed herein are methods of identifying a compound for treating or preventing an infection with an infectious microbe, such as a coronavirus, in a subject in need thereof. Also disclosed herein are compounds and compositions identified by said methods, and methods of use thereof. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/273161 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/352 (20130101) A61K 31/397 (20130101) Original (OR) Class A61K 31/436 (20130101) A61K 31/4375 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100026 | MARKOWITZ et al. |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); The United States Department of Veteran Affairs (Washington, District of Columbia) |
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| INVENTOR(S) | Sanford MARKOWITZ (Pepper Pike, Ohio); Joseph READY (Carrollton, Texas); Andrew PIEPER (Shaker Heights, Ohio) |
| ABSTRACT | A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor. |
| FILED | Thursday, May 11, 2023 |
| APPL NO | 18/196106 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/4365 (20130101) Original (OR) Class A61K 31/4375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100027 | BLAU et al. |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Helen M. BLAU (Stanford, California); Nidhi BHUTANI (Stanford, California); Mamta SINGLA (Stanford, California); Adelaida Rosa PALLA (Stanford, California) |
| ABSTRACT | The present disclosure provides methods of improving the structure and/or function of a joint tissue of a subject by administering to the subject an amount of a 15-PGDH inhibitor effective to inhibit 15-PGDH activity and/or reduce 15-PGDH levels in the subject. The methods described herein are useful for treating joint dysfunction and/or degeneration associated with aging, injury, disease, disorder, and/or condition. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 18/254441 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4365 (20130101) Original (OR) Class A61K 31/7105 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100076 | Yu et al. |
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| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
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| INVENTOR(S) | Robert Yu (North Augusta, South Carolina); Yutaka Itokazu (Augusta, Georgia) |
| ABSTRACT | Methods and compositions for treating neurodegenerative diseases are provided. In one embodiment, the method includes administering gangliosides into the brain of a mammal in need of such treatment. The gangliosiges are preferably GM1 and GD3 gangliosides. The gangliosides are intranasally administered in an amount effective to delay and/or prevent disease progression, and to increase the resilience of brains by promoting adult neurogenesis by gangliosides. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 18/262174 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7032 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240100079 — METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS IN THE INNER EAR OF ADULT MAMMALS
| US 20240100079 | Chen et al. |
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| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
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| INVENTOR(S) | Zheng-Yi Chen (Chestnut Hill, Massachusetts); Yi-Zhou Quan (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods for regenerating hair cells in an adult mammalian inner ear using novel combinations of agents selected from the group consisting of a histone deacetylase (HDAC) inhibitor, one or more inhibitory nucleic acids targeting Fir, Mxi1, Fbxw7, or a combination thereof, a Wnt pathway activator, and a cAMP activator. The methods and compositions can be used to treat a subject with hearing loss or vestibular dysfunction. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/275146 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 31/18 (20130101) A61K 31/19 (20130101) A61K 31/166 (20130101) A61K 31/352 (20130101) A61K 31/713 (20130101) Original (OR) Class A61K 33/14 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100081 | Ambati et al. |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Jayakrishna Ambati (Charlottesville, Virginia); Nagaraj Kerur (Beaver Creek, Ohio) |
| ABSTRACT | It is disclosed herein that RPE degeneration in human cell culture and in mouse models is driven by a non-canonical inflammasome pathway that results in activation of caspase-4 (also known as caspase-11 in mouse) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-β (IFN-β) production and gasdermin D-dependent interleukin-18 (IL-18) secretion. Reduction of DICER1 or accumulation of Alu RNA triggers cytosolic escape of mitochondrial DNA, which engages cGAS. Collectively, these data highlight an unexpected role for cGAS in responding to mobile element transcripts, reveal cGAS-driven interferon signaling as a conduit for mitochondrial damage-induced NLRP3 activation, and expand the immune sensing repertoire of cGAS and caspase-4 to non-infectious human disease. Coupled with the unexpected result that caspase-4, gasdermin D, IFN-β, and cGAS are elevated in the RPE of human eyes with geographic atrophy, these findings also identify new targets for a major cause of blindness. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/316981 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 16/249 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100120 | Toney et al. |
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| APPLICANT(S) | Board of Regents, The University of Taxas System (Austin, Texas) |
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| INVENTOR(S) | Glenn M. Toney (San Antonio, Texas); Allison D. Brackley (San Antonio, Texas) |
| ABSTRACT | The disclosure relates to compositions and methods of preventing, reducing, reversing or treating a subject suffering from opioid toxicity, overdose or opioid-induced respiratory depression or a subject at risk for developing opioid-induced respiratory depression. The method comprises administering to a patient in need of treatment an effective amount of oxytocin or an analog thereof. |
| FILED | Thursday, October 08, 2020 |
| APPL NO | 17/767743 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 38/095 (20190101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100124 | Chauhan et al. |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Bharesh Kumar Chauhan (Sewickley, Pennsylvania); Kanwal Nischal (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are methods of treating corneal opacities in patients, such as neonates, including administering to the patient's eye or cornea a ZBTB7B and/or granulin polypeptide, and/or knocking down expression of HAS2 and/or HYAL1 in the patient's eye or cornea. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 18/274317 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0048 (20130101) A61K 38/18 (20130101) Original (OR) Class A61K 38/1709 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100133 | HOFT et al. |
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| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri) |
| ASSIGNEE(S) | Saint Louis University (St. Louis, Missouri) |
| INVENTOR(S) | Daniel F. HOFT (St. Louis, Missouri); Valerio RASI (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to recombinant mutant Granzyme A molecules that lack enzymatic activity and their use in inhibiting Mycobacterium tuberculosis and treating the related disease states. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363255 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/482 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6467 (20130101) Enzymes C12Y 304/21078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100144 | CROYLE et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Maria A. CROYLE (Austin, Texas); Stephen Clay SCHAFER (Austin, Texas) |
| ABSTRACT | Immunogenic compositions comprising viral vectors and surfactants are provided. Methods for administration and preparation of such compositions are also provided. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/476042 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/543 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100152 | Tang et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pei Tang (Pittsburgh, Pennsylvania); Tommy Stevens Tillman (Pittsburgh, Pennsylvania); Yan Xu (Pittsburgh, Pennsylvania) |
| ABSTRACT | Recombinant polynucleotides including a nucleic acid sequence encoding an engineered SARS-CoV-2 spike protein (S12) or an immunogenic fragment thereof, in which the engineered spike protein or immunogenic fragment includes one or more mutations in the S2 segment of the S12 ectodomain. Vaccines, pharmaceutical compositions, and methods of use of the polynucleotides, vaccines, and pharmaceutical compositions in treating, alleviating, or managing SARS-CoV-2 infection and/or one or more symptoms thereof. |
| FILED | Wednesday, September 06, 2023 |
| APPL NO | 18/461955 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100154 | Fuerst et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); DANMARKS TEKNISKE UNIVERSITET (Lyngby, Denmark); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas R. Fuerst (Gaithersburg, Maryland); Eric A. Toth (Spring Grove, Pennsylvania); Nathan Lewis (San Diego, California); Bjorn Gunnar Voldborg (Lyngby, Denmark); Wan Tien Chiang (La Jolla, California) |
| ABSTRACT | Disclosed herein are methods of producing glyco-modified viral antigens that provide a shift of the glycosylation profile of recombinant produced viral antigens (e.g. glycoproteins) towards the naturally occurring viral antigens (e.g. glycoproteins). Disclosed are methods of producing a modified viral antigen comprising expressing a viral antigen in a recombinant mammalian cell line having one or more of the endogenous genes Mgat2, Mgat4A, Mgat4B, Mgat5, St3Gal3, St3Gal4, B4galt1, B4galt2, B4galt3, B4galt4, B4galt5, B3gnt2, St3Gal6, SPPL3, and/or FUT8 inactivated and/or downregulated; and optionally a gene ST6Gall inserted. Disclosed are glyco-modified viral antigens produced by the method of using a recombinant mammalian cell line. Disclosed are methods of treating a subject in need thereof comprising administering a composition comprising a therapeutically effective amount of one or more of the glyco-modified viral antigens. Disclosed are methods of screening for an antibody specific to one or more of the disclosed glyco-modified viral antigens. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 18/274741 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/29 (20130101) Original (OR) Class A61K 49/0004 (20130101) A61K 2039/6087 (20130101) Peptides C07K 1/1077 (20130101) C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100171 | Gendelman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard E. Gendelman (Omaha, Nebraska); Benson Edagwa (Omaha, Nebraska) |
| ABSTRACT | The present invention provides prodrugs and methods of use thereof. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 18/050351 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/146 (20130101) A61K 47/55 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100174 | Eddy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Eddy (Gainesville, Florida); Michael Harris (Gainesville, Florida); Amanda Pritzlaff (Gainesville, Florida) |
| ABSTRACT | Conjugation of polymers to proteins, including biomedically-relevant PEGylation, is a promising approach to address a central challenge of biologics and biotech: the lack of protein stability in demanding non-native environments. Application of conjugation is hindered by the lack of atomic level understanding of protein-polymerinteractions, preventing design of conjugates with predicted properties. An integrative structural and biophysical approach was used to address this challenge using a polymer-modified carbohydrate recognition domain of human galectin-3 (Gal3C), a lectin essential for cellular adhesion and potential biologic. Modification with PEG and other polymers dramatically increased Gal3C thermal stability and redirected its unfolding pathway through forming a stable intermediate. Distinct polymer properties which increased protein thermal stability were revealed. Structural details of Gal3C-polymer conjugates revealed by NMR pointed to the important role of polymer localization. Residues local to the site of conjugation were perturbed by polymer conjugation and these perturbations remained localized over a wide temperature range. For PEGylated conjugates, replacing key lysine residues within the PEG-perturbed region altered the protein-PEG interface and thermal unfolding behavior, providing mechanistic insight into rational design of conjugates that will expand the benefits of polymer conjugation. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/236078 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) Original (OR) Class Peptides C07K 14/7056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100178 | Kaur et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Chapman University (Orange, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kamaljit Kaur (Orange, California); Phi-Phung Than (Orange, California) |
| ABSTRACT | Disclosed herein are peptide-pharmaceutical agent conjugates and methods of treating cancer with the conjugates. |
| FILED | Friday, August 18, 2023 |
| APPL NO | 18/452405 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6809 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100179 | BAUM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENERON PHARMACEUTICALS, INC. (Tarrytown, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alina BAUM (Pleasantville, New York); Thomas NITTOLI (Pearl River, New York) |
| ABSTRACT | Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with influenza, including VX-787 and derivatives thereof, baloxavir and derivatives thereof, and baloxavir marboxil and derivatives thereof, and protein (e.g., antibody) drug conjugates thereof. |
| FILED | Monday, July 24, 2023 |
| APPL NO | 18/225567 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/5383 (20130101) A61K 47/6803 (20170801) A61K 47/6841 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100183 | Salem et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNiversity of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aliasger K. Salem (Iowa City, Iowa); David A. Stoltz (Iowa City, Iowa); Michael J. Welsh (Riverside, Iowa); Sarah Ernst (Kalona, Iowa); Youssef W. Naguib (Minia, Egypt); David S. NAkhla (Iowa City, Iowa); Aml I. Mekkawy (Sohag, Egypt); Nikesh Gupta (Iowa City, Iowa) |
| ABSTRACT | Composition and methods to prevent, inhibit or treat one or more symptoms of cystic fibrosis are provided. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 18/256593 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/0019 (20130101) A61K 31/47 (20130101) A61K 45/06 (20130101) A61K 47/6951 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100189 | ZECHIEDRICH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Twister Biotech, Inc (Houston, Texas); Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Twister Biotech, Inc (Houston, Texas); Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | E. Lynn ZECHIEDRICH (Houston, Texas); Lirio Milenka AREVALO-SOLIZ (Houston, Texas); Daniel James CATANESE, JR. (Houston, Texas); Jonathan Marcus FOGG (Houston, Texas); Christopher E. COKER (Houston, Texas) |
| ABSTRACT | MiniVectors and compositions containing MiniVectors that target genes implicated in IPF selected from CDH11, STAT3, STAT6, FoxM1, MDM2, TGFβ, SMAD, PDGFA, or TLR4 and/or increase intracellular levels of reduced glutathione, relaxin, and p53, are provided, along with uses in the treatment of idiopathic pulmonary fibrosis. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/930298 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1758 (20130101) A61K 38/2221 (20130101) A61K 48/0066 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1136 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100191 | Ansari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Aseem Ansari (Germantown, Tennessee); Graham Erwin (Sunnyvale, California); Matthew Grieshop (Wauwatosa, Wisconsin) |
| ABSTRACT | The present technology relates to compositions and methods for modulating expression of genes which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence. |
| FILED | Wednesday, July 05, 2023 |
| APPL NO | 18/218325 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5517 (20130101) A61K 47/60 (20170801) A61K 47/545 (20170801) A61K 47/595 (20170801) A61K 48/0041 (20130101) A61K 48/0066 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Heterocyclic Compounds C07D 495/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/00 (20130101) C12N 15/11 (20130101) C12N 2310/113 (20130101) C12N 2310/152 (20130101) C12N 2310/343 (20130101) C12N 2310/3513 (20130101) C12N 2310/3519 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100192 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Osama Abudayyeh (Cambridge, Massachusetts); Jonathan S. Gootenberg (Cambridge, Massachusetts); Wenyuan Zhou (Cambridge, Massachusetts); Alisan Kayabolen (Brookline, Massachusetts); Cian Franz Schmitt-Ulms (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides systems, methods, and compositions for site specific genetic engineering comprising the use of CRISPR effectors and trans-splicing. The disclosure also relates to methods of using the systems and compositions for treating diseases as well as diagnostics. |
| FILED | Thursday, August 24, 2023 |
| APPL NO | 18/455380 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100336 | Kressel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Feinstein Institutes for Medical Research (Manhasset, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam M. Kressel (Plainview, New York); Valentin A. Pavlov (Bayside, New York); Sangeeta S. Chavan (Syosset, New York); Kevin J. Tracey (Old Greenwich, Connecticut) |
| ABSTRACT | Methods for electrical modulation of inflammation or serum TNF levels in a subject. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/373673 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0412 (20130101) A61N 1/0504 (20130101) A61N 1/0536 (20130101) A61N 1/3615 (20130101) A61N 1/36053 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100354 | Tian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bozhi Tian (Chicago, Illinois); Menahem Rotenberg (Chicago, Illinois); Aleksander Prominski (Chicago, Illinois) |
| ABSTRACT | This disclosure relates to methods for modulating activity of cells and tissue with materials that are capable of being activated by light, such methods useful for treating diseases. The disclosure also provides devices and systems suitable for use in such methods, particularly devices and systems having oxygen plasma-treated p-type (boron) silicon. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/768329 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 2005/0626 (20130101) A61N 2005/0659 (20130101) A61N 2005/0662 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100777 | DEAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. David DEAN (Shaker Heights, Ohio); Al SIBLANI (Dearborn Heights, Michigan); Eric J. MOTT (Plainwell, Michigan); John P. FISHER (Kensington, Maryland); Martha O. WANG (Columbia, Missouri); Antonios G. MIKOS (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | H. David DEAN (Shaker Heights, Ohio); Al SIBLANI (Dearborn Heights, Michigan); Eric J. MOTT (Plainwell, Michigan); John P. FISHER (Kensington, Maryland); Martha O. WANG (Columbia, Missouri); Antonios G. MIKOS (Houston, Texas) |
| ABSTRACT | A light polymerizable composition for use in the additive manufacturing of medical devices may include a first photo-initiator and a second photo-initiator. The first photo-initiator activates to initiate curing of the composition when exposed to light of a first wavelength in an additive manufacturing device and the second photo-initiator limits the transmission of the light of the first wavelength that activates the first photo-initiator in the additive manufacturing device. The second photo-initiator is activated to further cure the composition when exposed to a light of a second wavelength different from the first wavelength by activating the second photo-initiator to produce free radicals at a higher rate when exposed to the light of the second wavelength than when exposed to the light of the first wavelength. |
| FILED | Monday, November 27, 2023 |
| APPL NO | 18/519764 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) A61L 27/56 (20130101) A61L 27/60 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/135 (20170801) B29C 64/386 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/029 (20130101) G03F 7/0047 (20130101) G03F 7/105 (20130101) G03F 7/2008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101509 | PEI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dehua PEI (Columbus, Ohio); George APPIAH KUBI (Columbus, Ohio); Ziqing QIAN (Wellesley, Massachusetts) |
| ABSTRACT | Disclosed are compounds that can penetrate the mitochondrial membrane and that are able to deliver cargo (e.g., therapeutic agents) specifically to the mitochondria. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/498102 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 47/542 (20170801) Acyclic or Carbocyclic Compounds C07C 279/12 (20130101) Original (OR) Class Peptides C07K 5/06086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101518 | PARNELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vettore, LLC (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Mark PARNELL (Kaysville, Utah); John MCCALL (Boca Grande, Florida) |
| ABSTRACT | Provided herein is a method for treating a monocarboxylate transporter MCT4-mediated disorder in a subject in need thereof. The method comprises the step of administering to the subject a compound of structural Formula I and/or a salt thereof. The treatment of the monocarboxylate transporter MCT4-mediated disorder may inhibit activity of MCT4, or a mutant thereof, sometimes with at least a 100-fold selevtivity for MCT4 over MCT1. |
| FILED | Monday, June 19, 2023 |
| APPL NO | 18/337313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) A61K 31/427 (20130101) A61K 31/4155 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 231/12 (20130101) Original (OR) Class C07D 401/06 (20130101) C07D 405/12 (20130101) C07D 409/04 (20130101) C07D 417/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101541 | Ghosh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Andrew Mesecar (West Lafayette, Indiana); Hiroaki Mitsuya (Kumamoto, Japan) |
| ABSTRACT | Bis-amide inhibitors of SARS-CoV-2 (COVID) and methods of using them to treat a severe acute respiratory syndrome. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 18/255341 |
| CURRENT CPC | Heterocyclic Compounds C07D 409/12 (20130101) Original (OR) Class C07D 409/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101580 | BURNS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Venatorx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. BURNS (Malvern, Pennsylvania); Daniel C. PEVEAR (Downingtown, Pennsylvania); Luigi XERRI (Wayne, Pennsylvania); Timothy HENKEL (Berwyn, Pennsylvania); Daniel MCGARRY (Malvern, Pennsylvania); Lawrence ROSEN (Malvern, Pennsylvania); Gerald BRENNER (Plymouth, Pennsylvania); Jean-Baptiste ARLIN (Amsterdam, Netherlands); Ana FERNANDEZ CASARES (Amsterdam, Netherlands) |
| ABSTRACT | Described herein are crystalline forms of (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid. In some embodiments, the crystalline forms are formulated for treating a subject in need thereof with a bacterial infection. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/476050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0095 (20130101) A61K 31/546 (20130101) A61K 47/02 (20130101) A61K 47/12 (20130101) A61K 47/26 (20130101) A61K 47/183 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101590 | ROMESBERG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Floyd E. ROMESBERG (La Jolla, California); Denis A. MALYSHEV (Solana Beach, California); Lingjun LI (San Diego, California); Thomas LAVERGNE (Le Versoud, France); Zhengtao LI (Pudong new district, China PRC) |
| ABSTRACT | Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/112952 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/00 (20130101) C07H 19/24 (20130101) Original (OR) Class C07H 21/00 (20130101) C07H 21/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/1024 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6832 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101601 | Hausner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Sven H. Hausner (Sacramento, California); Julie L. Sutcliffe (Sebastopol, California) |
| ABSTRACT | The present invention provides bi-terminal PEGylated peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates of the present invention further comprise a biological agent such as an imaging agent or a therapeutic agent, e.g., covalently attached to one of the PEG moieties. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating integrin-mediated diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, chronic fibrosis, chronic obstructive pulmonary disease (COPD), lung emphysema, and chronic wounding skin disease. Compositions and kits containing the peptide conjugates of the present invention find utility in a wide range of applications including, e.g., in vivo imaging and immunotherapy. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/945457 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 38/00 (20130101) A61K 47/60 (20170801) A61K 47/64 (20170801) A61K 51/082 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 14/70546 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/32122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101606 | Chong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lucy S. Chong (Pasadena, California); Ronghui Zhu (Pasadena, California); Xiaofei Ge (Beijing, China PRC); Michael B. Elowitz (Pasadena, California); Mark W. Budde (Arcadia, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments. |
| FILED | Thursday, May 11, 2023 |
| APPL NO | 18/316102 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101607 | McFadden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Douglas Grant McFadden (Gainesville, Florida); Alfred S. Lewin (Gainesville, Florida); Alexandra Rose Lucas (Gainesville, Florida); Cristhian J. Ildefonso (Gainesville, Florida); Mohammed Masmudur Rahman (Gainesville, Florida) |
| ABSTRACT | Disclosed are methods and compositions for preventing, treating, and/or ameliorating one or more symptoms of inflammation in a mammal. In particular, viral vectors and medicaments containing them are disclosed, which are useful in the prophylaxis, therapy, or amelioration of symptoms of one or more inflammatory-mediated mammalian diseases, such as age-related macular degeneration (AMD), arthritis, Bechet's disease, Best macular dystrophy, corneal inflammation, diabetic retinopathy, drusen formation, dry AMD, dry eye, geographic atrophy, glaucomaocular neovascularization, Lupus erythematosus, macular degeneration, Mallatia Leventinese and Doyne honeycomb retinal dystrophy, nephritis, ocular hypertension, ocular inflammation, recurrent uveitis, Sorsby fundus dystrophy, vasculitis, vitreoretinopathy, wet AMD, or related disorders. In exemplary methods, administration of a pharmaceutical composition comprising a recombinant viral vector that delivers a secretable and cell-penetrating M013 protein or peptide to a subject in need thereof facilitated treatment of particular human disorders such as AMD, ocular neovascularization, uveitis, and related inflammatory ocular disease. |
| FILED | Tuesday, May 09, 2023 |
| APPL NO | 18/314773 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/162 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2710/24022 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101609 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Institute for Research in Biomedicine (Bellinzona, Switzerland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servi (Bethesda, Maryland); Institute for Research in Biomedicine (Bellinzona, Switzerland) |
| INVENTOR(S) | Baoshan Zhang (Bethesda, Maryland); Guillaume Stewart-Jones (Cambridge, Massachusetts); Tongqing Zhou (Boyds, Maryland); John Mascola (Rockville, Maryland); Kai Xu (Rockville, Maryland); Yongping Yang (Potomac, Maryland); Paul Thomas (Washington, District of Columbia); Gwo-Yu Chuang (Rockville, Maryland); Li Ou (Potomac, Maryland); Peter Kwong (Washington, District of Columbia); Yaroslav Tsybovsky (Brunswick, Maryland); Wing-Pui Kong (Germantown, Maryland); Aliaksandr Druz (Germantown, Maryland); Davide Corti (Bellinzona, Switzerland); Antonio Lanzavecchia (Bellinzona, Switzerland) |
| ABSTRACT | Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537448 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/18634 (20130101) C12N 2760/18734 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101610 | BEERNINK |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children’s Hospital and Research Center at Oakland (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter T. BEERNINK (Walnut Creek, California) |
| ABSTRACT | Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising such proteins, and methods of use of such proteins, are provided. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/493141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/095 (20130101) A61K 2039/55505 (20130101) Peptides C07K 14/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101615 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zibo CHEN (Seattle, Washington); Scott Boyken (Seattle, Washington); Sherry Bermeo (Seattle, Washington); Robert A. Langan (Seattle, Washington); David Baker (Seattle, Washington) |
| ABSTRACT | Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/158384 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 10/00 (20130101) B82Y 15/00 (20130101) Peptides C07K 14/00 (20130101) C07K 14/435 (20130101) Original (OR) Class C07K 19/00 (20130101) C07K 2319/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) Computer Systems Based on Specific Computational Models G06N 3/002 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/10 (20190201) G16B 15/00 (20190201) Pulse Technique H03K 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101620 | Imperiali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Barbara Imperiali (Cambridge, Massachusetts); Cristina Zamora (Medford, Massachusetts); Elizabeth Ward (Somerville, Massachusetts) |
| ABSTRACT | Glycan-binding proteins, and compositions thereof, are generally described, including methods of making and using such proteins. The proteins may include scaffolds based on easily evolvable DNA-binding proteins, with binding sites able to specifically bind to mono- or disaccharides, such as monosaccharide-binding determinants, disaccharide-binding determinants, more complex carbohydrates, etc. In certain aspects, a protein may be generated starting from a small DNA-binding protein, such as Sso7d. Such glycan-binding proteins may have numerous applications, including in enzyme-linked immunosorbent assays (ELISAs), glycan characterization, cell selection, flow cytometry, histology, imaging, arrays, affinity purification, enzyme-linked visualization, binding to a target for pharmaceutical purposes, etc. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/160144 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101624 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong-Xu Wang (Southborough, Massachusetts); Qingbo Chen (Worcester, Massachusetts) |
| ABSTRACT | Methods of treating or reducing the risk of obesity and/or obesite-related disorders, e.g., metabolic syndrome, hepatic and non-hepatic steatosis, and diabetes, using C20orf27 proteins or nucleic acids. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/473627 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 14/4705 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101625 | Storkus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Walter J. Storkus (Glenshaw, Pennsylvania); Michael S. Kinch (Laytonsville, Maryland) |
| ABSTRACT | EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative derivatives thereof. The EphA2 T-cell epitopes are useful in an assay, such as an ELISPOT assay, that may be used to determine and/or quantify a patient's immune responsiveness to EphA2. The epitopes also are useful in methods of modulating a patient's immune reactivity to EphA2, which has substantial utility as a treatment for cancers that overexpress EphA2, such as renal cell carcinoma (RCC). The EphA2 epitopes also can be used to vaccinate a patient against EphA2, by in vivo or ex vivo methods. |
| FILED | Wednesday, September 06, 2023 |
| APPL NO | 18/461658 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1793 (20130101) A61K 39/0011 (20130101) A61K 2039/55566 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/47 (20130101) C07K 14/705 (20130101) C07K 14/4748 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/5091 (20130101) G01N 33/56966 (20130101) G01N 33/56972 (20130101) G01N 2333/57 (20130101) G01N 2333/5409 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101637 | SPUDICH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| INVENTOR(S) | John Lee SPUDICH (Houston, Texas); Elena G. GOVORUNOVA (Houston, Texas); Oleg A. SINESHCHEKOV (Houston, Texas); Mingshan XUE (Houston, Texas) |
| ABSTRACT | Methods and compositions used to identify and characterize novel rhodopsin domains, which are kalium (potassium)-conducting channelrhodopsins. The rhodopsin domain of these kalium (potassium)-conducting channelrhodopsins have been cloned, optimized and expressed in mammalian systems and thus may be used in, among others, optogenetic applications and as therapeutic agents for electrically active cell mediated disorders. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465333 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/705 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101646 | GEORGIEV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ivelin Stefanov GEORGIEV (Nashville, Tennessee); Andrea R. SHIAKOLAS (Nashville, Tennessee); Kevin J. KRAMER (Nashville, Tennessee) |
| ABSTRACT | The present disclosure relates to antibodies and uses thereof for treating, preventing, and detecting coronavirus infection. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 18/273625 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1003 (20230801) Original (OR) Class C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101650 | Achkar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacqueline M. Achkar (Brooklyn, New York); Elise Ishida (Aiea, Hawaii); Yanyan Liu (Bronx, New York); Tingting Chen (Bronx, New York) |
| ABSTRACT | Provided are high affinity Mycobacterium tuberculosis arabinomannan-specific antibodies and antigen-binding fragments thereof. Also provided are methods of use and devices employing such Mycobacterium tuberculosis arabinomannan-specific antibodies and antigen-binding fragments thereof. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 18/256556 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Peptides C07K 16/1289 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/77 (20130101) C07K 2317/92 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5695 (20130101) G01N 33/54386 (20130101) G01N 2333/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101658 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia); The US Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | Augusta University Research Institute, Inc. (Augusta, Georgia); The US Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Kebin Liu (Augusta, Georgia); John Klement (Augusta, Georgia); Priscilla S. Redd (Augusta, Georgia) |
| ABSTRACT | Antibodies and antigen binding fragments thereof that immunospecifically bind OPN (OPN) and inhibit OPN activity are provided herein. The disclosed antibodies and antigen binding fragments are useful for modulating signal transduction through OPN proteins. The antibodies and antigen-binding fragments are useful for the treatment or prevention of cancer, osteoporosis, or other immune diseases. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/460277 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101685 | Kobayashi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human (Baltimore, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| INVENTOR(S) | Hisataka Kobayashi (Laurel, Maryland); Peter Choyke (Rockville, Maryland) |
| ABSTRACT | Provided herein are methods of treating a subject with cancer using a therapeutically effective amount of one or more one or more tumor-specific antibody-IR700 molecules. The methods can further include administering to the subject a therapeutically effective amount of (a) one or more CTLA4 antibody-IR700 molecules, one or more PD-L1 antibody-IR700 molecules, or combinations thereof, (b) one or more reducing agents, (c) one or more immunoactivators, or combinations of a, b, and c, for example, either simultaneously or substantially simultaneously with the tumor-specific antibody-IR700 molecules, or sequentially (for example, within about 0 to 24 hours). The method also includes irradiating the subject or cancer cells in the subject (for example, a tumor or cancer cells in the blood) at a wavelength of 660 to 740 nm at a dose of at least 1 J/cm2. The use of one or more reducing agents can reduce edema resulting from treatment. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 18/263394 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7004 (20130101) A61K 39/3955 (20130101) A61K 2039/507 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0616 (20130101) A61N 2005/0659 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 16/2884 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101694 | Kuchroo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BRIGHAM AND WOMEN’S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | THE BRIGHAM AND WOMEN’S HOSPITAL, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Vijay K. Kuchroo (Newton, Massachusetts); Sheng XIAO (Newton, Massachusetts) |
| ABSTRACT | The compositions and methods described herein are based, in part, on the discovery that regulatory B cells (Bregs) differentially express a specific set of coinhibitory molecules, including TIGIT, LAG-3, PD-1, CTLA4, and TIM-3. The data described herein indicate that TIGIT is required for both Breg-mediated tolerance maintenance at the steady state, and inflammation restraint during autoimmune and inflammatory diseases. Accordingly, provided herein are compositions and methods targeting coinhibitory molecules, such as TIGIT, LAG-3, PD-1, CTLA4, and TIM-3, in B cells, as novel therapeutic strategies for modulating immune suppression and treating diseases mediated or impacted by immune suppression mechanisms, such as autoimmune diseases and cancers. |
| FILED | Tuesday, June 27, 2023 |
| APPL NO | 18/342646 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 67/0276 (20130101) A01K 2217/075 (20130101) A01K 2217/206 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) A01K 2267/0387 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) A61P 29/00 (20180101) A61P 35/00 (20180101) A61P 37/00 (20180101) Peptides C07K 14/70503 (20130101) C07K 16/244 (20130101) C07K 16/2803 (20130101) C07K 16/2818 (20130101) C07K 16/2878 (20130101) C07K 16/2887 (20130101) Original (OR) Class C07K 2317/569 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101695 | PENICHET et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Manuel L. PENICHET (Los Angeles, California); Pierre V. CANDELARIA (Los Angeles, California); Miguel NAVA (Los Angeles, California); Tracy R. WELLS (Los Angeles, California) |
| ABSTRACT | Aspects of the disclosure relate to antibodies and methods of use. Various antibodies are disclosed, including engineered antibodies targeting CD138, CD38, and TfR1. Certain aspects are directed to IgE antibodies and use in diagnosis and/or treatment of cancer. Also disclosed are kits and pharmaceutical compositions comprising one or more engineered antibodies. |
| FILED | Wednesday, September 01, 2021 |
| APPL NO | 18/043554 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101699 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Bin Liu (San Francisco, California); Yang Su (San Francisco, California); Scott Bidlingmaier (San Francisco, California) |
| ABSTRACT | A method to upregulate CD46 cell surface expression and combination therapies for various cancers employing an anti-CD46 antibody and an immunomodulatory imide drug (IMiD) or a Signal Transducer And Activator of Transcription 3 (STAT3) inhibitor or both are provided. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 18/271205 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/573 (20130101) A61K 47/6849 (20170801) A61K 47/68031 (20230801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101782 | Byers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffery Byers (Newton, Massachusetts); Connor Gallin (Yonkers, New York) |
| ABSTRACT | The disclosure provides compositions comprising a polymer, a Lewis acid, and a solvent and methods of using the same for ring closing depolymerization of polymers. |
| FILED | Tuesday, August 22, 2023 |
| APPL NO | 18/453763 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/16 (20130101) Original (OR) Class C08J 2335/02 (20130101) C08J 2369/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101962 | EVANS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Salk Institute for Biological Studies (La Jolla, California) |
| ASSIGNEE(S) | Salk Institute for Biological Studies (La Jolla, California) |
| INVENTOR(S) | Ronald EVANS (La Jolla, California); Michael DOWNES (La Jolla, California); Annette ATKINS (La Jolla, California); Eiji YOSHIHARA (La Jolla, California); Ruth YU (La Jolla, California) |
| ABSTRACT | The invention features pancreatic islet and pancreatic organoids, and cell cultures and methods that are useful for the rapid and reliable generation of pancreatic islet and pancreatic islet organoids. The invention also features methods of treating pancreatic diseases and methods of identifying agents that are useful for treatment of pancreatic diseases, such as type 2 diabetes and pancreatic cancer, using the pancreatic islet and pancreatic organoids of the invention. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/340537 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/39 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0677 (20130101) Original (OR) Class C12N 2501/16 (20130101) C12N 2501/117 (20130101) C12N 2501/385 (20130101) C12N 2501/395 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2501/999 (20130101) C12N 2502/28 (20130101) C12N 2502/1382 (20130101) C12N 2503/02 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) G01N 2800/04 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101969 | Gradinaru et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viviana Gradinaru (Pasadena, California); Nicholas C. Flytzanis (Thousand Oaks, California); Nicholas S. Goeden (Thousand Oaks, California) |
| ABSTRACT | Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms showing increased specificity and efficiency of viral transduction in targeted cell types such as the brain and lung. The rAAV compositions described herein also have tropisms showing decreased specificity and decreased efficiency of viral transduction in an off-target cell type such as the liver. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. Upon systemic delivery to a subject, the rAAV is capable of increased specificity and increased transduction of the transgene in a target cell-type, as compared to a parental or reference AAV. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503972 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2750/14071 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101973 | Stafford et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrel W. Stafford (Carrboro, North Carolina); Tao Li (San Diego, California) |
| ABSTRACT | The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells. |
| FILED | Wednesday, March 15, 2023 |
| APPL NO | 18/184198 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) Original (OR) Class C12N 9/50 (20130101) C12N 9/64 (20130101) C12N 9/88 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/172 (20130101) Enzymes C12Y 101/04001 (20130101) C12Y 304/21006 (20130101) C12Y 401/0109 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101995 | Parkinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Elizabeth I. Parkinson (West Lafayette, Indiana); Matthew A. Hostetler (Huntington, West Virginia) |
| ABSTRACT | The present disclosure teaches a method of treating a patient in need of therapeutic intervention with bioactive cyclic peptide molecules which are useful as antimicrobials, anticancer agents, antiparasitic, immunosuppressants, and others. |
| FILED | Thursday, November 30, 2023 |
| APPL NO | 18/525840 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) Peptides C07K 7/64 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102001 | SCHARENBERG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SEATTLE CHILDREN'S HOSPITAL (dba SEATTLE CHILDREN'S RESEARCH INSTITUTE) (Seattle, Washington) |
| ASSIGNEE(S) | SEATTLE CHILDREN'S HOSPITAL (dba SEATTLE CHILDREN'S RESEARCH INSTITUTE) (Seattle, Washington) |
| INVENTOR(S) | Andrew M. SCHARENBERG (Seattle, Washington); Michael T. CERTO (Seattle, Washington); Kamila Sabina GWIAZDA (Seattle, Washington) |
| ABSTRACT | The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/526930 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) A61K 38/45 (20130101) A61K 38/52 (20130101) A61K 38/465 (20130101) A61K 2035/124 (20130101) Peptides C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/90 (20130101) C12N 9/1252 (20130101) C12N 15/62 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2800/80 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102004 | Bauer et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel E. Bauer (Boston, Massachusetts); Stuart H. Orkin (Boston, Massachusetts); Neville Espi Sanjana (Cambridge, Massachusetts); Ophir Shalem (Cambridge, Massachusetts); Jason Wright (Cambridge, Massachusetts); Feng Zhang (Cambridge, Massachusetts) |
| ABSTRACT | The application relates to a deep scanning mutagenesis library to interrogate phenotypic changes in a population of cells comprising a plurality of CRISPR-Cas system guide RNAs targeting genomic sequences within at least one continuous genomic region, wherein the guide RNAs target at least 100 genomic sequences upstream of a PAM sequence for every 1000 base pairs within the continuous genomic region and methods for their use. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345958 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) C12N 15/1075 (20130101) C12N 15/1079 (20130101) Original (OR) Class C12N 15/1082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102010 | Hannon et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York) |
| ASSIGNEE(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York) |
| INVENTOR(S) | Gregory J. Hannon (Cold Spring Harbor, New York); Sihem Cheloufi (Boston, Massachusetts) |
| ABSTRACT | Provided is an improved design of shRNA based on structural mimics of miR-451 precursors. These miR-451 shRNA mimics are channeled through a novel small RNA biogenesis pathway, require AGO2 catalysis and are processed by Drosha but are independent of DICER processing. This miRNA pathway feeds active elements only into Ago2 because of its unique catalytic activity. These data demonstrate that this newly identified small RNA biogenesis pathway can be exploited in vivo to produce active molecules. |
| FILED | Friday, August 04, 2023 |
| APPL NO | 18/365787 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2207/05 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102030 | Harvey et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Colin Harvey (Mountain View, California); Ulrich Schlecht (Sunnyvale, California); Maureen Elizabeth Hillenmeyer (Palo Alto, California) |
| ABSTRACT | Inducible promoters for the coordinated expression of at least one heterologous gene in yeast and methods of using them are disclosed. In particular, the invention relates to sets of inducible promoters derived from S. cerevisiae and related species that can be induced in the presence of nonfermentable carbon sources. |
| FILED | Wednesday, September 06, 2023 |
| APPL NO | 18/462158 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/81 (20130101) Original (OR) Class C12N 15/635 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102032 | Doudna et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Patrick Pausch (Berkeley, California); Katarzyna Soczek (Berkeley, California); Steven E. Jacobsen (Agoura Hills, California); Zheng Li (Los Angeles, California) |
| ABSTRACT | The present disclosure provides CRISPR-Cas effector polypeptides that exhibit enhanced gene editing and/or trans cleavage activity, compared to a wild-type CasPhi polypeptide. The present disclosure provides systems and kits comprising such CRISPR-Cas effector polypeptides. The present disclosure provides methods, including gene editing and diagnostic methods, using a CRISPR-Cas effector polypeptide of the present disclosure. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/273685 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/8213 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/121 (20130101) C12N 2310/3519 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102050 | BAILEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachel M. BAILEY (Trophy Club, Texas); Steven J GRAY (Southlake, Texas) |
| ABSTRACT | The present disclosure provides methods and compositions for the treatment of diseases and/or disorders in a subject, including, but not limited to neurological disorders such as giant axonal neuropathy. The methods described herein include direct administration of a gene therapy (e.g. an rAAV viral vector) to a subject via injection into a vagus nerve (e.g. the left vagus nerve) of the subject. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/355380 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) Peptides C07K 14/01 (20130101) C07K 16/081 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102080 | Seelig et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/536654 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102092 | Vogelstein et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Frankford, Delaware); Nickolas Papadopoulos (Towson, Maryland); Isaac A. Kinde (Beaumont, California) |
| ABSTRACT | The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ≥95% of them contain the identical mutation. We illustrate the utility of this approach for determining the fidelity of a polymerase, the accuracy of oligonucleotides synthesized in vitro, and the prevalence of mutations in the nuclear and mitochondrial genomes of normal cells. |
| FILED | Monday, November 27, 2023 |
| APPL NO | 18/519727 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2525/179 (20130101) C12Q 2525/191 (20130101) C12Q 2563/179 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102102 | Chaudhuri et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Aadel Chaudhuri (St. Louis, Missouri); Kevin Chen (St. Louis, Missouri); Pradeep Chauhan (St. Louis, Missouri); Zachary Smith (St. Louis, Missouri); Vivek Arora (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of treatments, monitoring treatment or progression, or methods for detecting utDNA in a subject having or suspected of having a urinary tract-associated cancer. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 18/261874 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102104 | AGRAWAL et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Nishant AGRAWAL (Chicago, Illinois); Rifat HASINA (Chicago, Illinois); Evgeny IZUMCHENKO (Chicago, Illinois) |
| ABSTRACT | Described herein is a method for evaluating a subject comprising detecting genetic mutation(s) in the DNA sequence of one or more oral cavity squamous cell carcinoma (OCSCC) biomarker(s) in a biological sample from the subject comprising DNA, wherein the OCSCC biomarker(s) comprise TP53, CDKN2A, FAT1, CASP8, NOTCH1, PIK3CA, and/or ERAS. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 18/266404 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102107 | ZHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Yan ZHENG (Chicago, Illinois); Yuanyuan ZHA (Chicago, Illinois); Robbert M. SPAAPEN (Chicago, Illinois); Thomas F. GAJEWSKI (Chicago, Illinois) |
| ABSTRACT | Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/489962 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1137 (20130101) C12N 15/1138 (20130101) C12N 2310/14 (20130101) C12N 2320/30 (20130101) C12N 2320/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) G01N 33/57484 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) Technologies for Adaptation to Climate Change Y02A 90/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102115 | Sabeti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pardis Sabeti (Cambridge, Massachusetts); Cameron Myhrvold (Cambridge, Massachusetts); Jon Arizti Sanz (Cambridge, Massachusetts); Alexandra Stanton (Cambridge, Massachusetts); Brittany Petros (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are compositions and methods of CRISPR effector system mediated detection of targets, including, but not limited to viral targets. Also described herein are devices and kits for carrying out the CRISPR effector system mediated nucleic acid detection assays. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 18/023538 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54388 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102730 | Andrews et al. |
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| FUNDED BY |
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| APPLICANT(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| ASSIGNEE(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| INVENTOR(S) | Robert R. Andrews (Norfolk, Massachusetts); Herman E. Snyder (W. Lafayette, Indiana); William J. Merritt (Danvers, Massachusetts); Evan P. Ordway (Salem, Massachusetts); Clair Strohl (Emmaus, Pennsylvania); Russell Barron (Boston, Massachusetts) |
| ABSTRACT | The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/096645 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/16 (20130101) Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 3/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102901 | Warrick et al. |
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| FUNDED BY |
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| APPLICANT(S) | SALUS DISCOVERY, LLC (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Warrick (Madison, Wisconsin); Cody Carrell (Sun Prairie, Wisconsin); Brianna Mullins (DeForest, Wisconsin); David Beebe (Monona, Wisconsin); Ryan Shogren (Madison, Wisconsin); Patrick McMinn (Madison, Wisconsin); Mitch Geiger (Madison, Wisconsin); Madalyn Gill (Madison, Wisconsin); Jeffrey Robert Staszak (Deerfield, Wisconsin); Visnu Devi Fraenkel (Madison, Wisconsin); Antonio Gatta (Philadelphia, Pennsylvania); Eric S. Mackey (Wales, Wisconsin); McKayla Rae Barber (Madison, Wisconsin); Randi Marie Degg (Seattle, Washington); Madeline Sides (Carmichael, California); Douglas Paul Barnes (Charlotte, North Carolina); Franklin Cheng Zhong (Lee's Summit, Missouri); Mindy Phung (Houston, Texas) |
| ABSTRACT | Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/373110 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4005 (20130101) Original (OR) Class G01N 33/493 (20130101) G01N 2001/4088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102991 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuedong Liu (Niwot, Colorado); Douglas A. Chapnick (Boulder, Colorado); William Old (Boulder, Colorado); Tristan D. Mcclure-Begley (Falls Church, Virginia); Eric Bunker (Derwood, Maryland) |
| ABSTRACT | Provided are FRET-based biosensor constructs, and multiplexed platforms or arrays of these biosensor constructs useful for screening candidate drug molecules for efficacy and/or specificity of drug activity. Optionally the biosensor constructs may be located on an inner membrane within a cell or engineered to be located on the cell's surface. The cells or cell lines displaying the biosensors on a cell surface may be arranged as an array of cells for high throughput evaluation of the efficacy and/or specificity of drug candidates, such as a library of candidate drug compounds. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/386764 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 2300/0636 (20130101) Apparatus for Enzymology or Microbiology; C12M 1/3476 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 2500/00 (20130101) C12Q 2560/00 (20130101) C12Q 2563/107 (20130101) C12Q 2563/179 (20130101) C12Q 2565/1015 (20130101) C12Q 2600/136 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 21/6428 (20130101) G01N 21/6452 (20130101) G01N 33/542 (20130101) G01N 33/554 (20130101) G01N 33/582 (20130101) G01N 33/5008 (20130101) Original (OR) Class G01N 2500/04 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103012 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Juno Therapeutics, Inc. (Seattle, Washington); Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Juno Therapeutics, Inc. (Seattle, Washington); Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | He LI (Seattle, Washington); Mark J. GILBERT (Seattle, Washington); David MALONEY (Seattle, Washington); Stanley R. RIDDELL (Seattle, Washington); Cameron J. TURTLE (Seattle, Washington) |
| ABSTRACT | Provided are methods, kits and compositions related to toxicity associated with administration of cell therapy for the treatment of diseases or conditions, e.g., cancer, including methods for use in predicting and treating a toxicity. In some embodiments, the toxicity is a neurotoxicity or cytokine release syndrome (CRS), such as a severe neurotoxicity or a severe CRS. The methods generally involve detecting a parameter of a biomarker or individually a parameter of each biomarker in a panel of biomarkers, such as a concentration, amount or activity, and comparing the detected parameter to a reference value for the parameter to determine if the subject is at risk for developing the toxicity, such as neurotoxicity or CRS or severe neurotoxicity or severe CRS. In some embodiments, the methods further involve administering an agent or therapy for treating, ameliorating, preventing, delaying and/or attenuating the development of the toxicity, such as neurotoxicity or CRS, such as severe neurotoxicity or severe CRS. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/476120 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) Original (OR) Class G01N 33/6866 (20130101) G01N 33/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103013 | Steyaert et al. |
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| FUNDED BY |
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| APPLICANT(S) | VIB VZW (Gent, Belgium); Vrije Universiteit Brussel (Brussels, Belgium); The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jan Steyaert (Beersel, Belgium); Els Pardon (Wezemaal, Belgium); Soren G.F. Rasmussen (Frederiksberg, Denmark); Juan Jose Fung (San Jose, California); Brian Kobilka (Palo Alto, California); Toon Laeremans (Dworp, Belgium) |
| ABSTRACT | The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases. |
| FILED | Wednesday, July 26, 2023 |
| APPL NO | 18/359483 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/705 (20130101) C07K 14/723 (20130101) C07K 16/28 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/20 (20130101) G01N 33/68 (20130101) G01N 33/566 (20130101) G01N 33/6857 (20130101) G01N 33/6872 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103103 | Conolly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Steven M. Conolly (Palo Alto, California); Patrick W. Goodwill (San Francisco, California); Daniel Hensley (Berkeley, California); Zhi Wei Tay (Berkeley, California); Bo Zheng (Berkeley, California) |
| ABSTRACT | A pulsed magnetic particle imaging system includes a magnetic field generating system that includes at least one magnet, the magnetic field generating system providing a spatially structured magnetic field within an observation region of the magnetic particle imaging system such that the spatially structured magnetic field will have a field-free region (FFR) for an object under observation having a magnetic nanoparticle tracer distribution therein. The pulsed magnetic particle imaging system also includes a pulsed excitation system arranged proximate the observation region, the pulsed excitation system includes an electromagnet and a pulse sequence generator electrically connected to the electromagnet to provide an excitation waveform to the electromagnet, wherein the electromagnet when provided with the excitation waveform generates an excitation magnetic field within the observation region to induce an excitation signal therefrom by at least one of shifting a location or condition of the FFR. The pulsed magnetic particle imaging system further includes a detection system arranged proximate the observation region, the detection system being configured to detect the excitation signal to provide a detection signal. The excitation waveform includes a transient portion and a substantially constant portion. |
| FILED | Monday, June 05, 2023 |
| APPL NO | 18/205937 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/10 (20130101) G01R 33/1276 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240104724 | GANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Jianan GANG (Baltimore, Maryland); Joseph Webster STAYMAN (Baltimore, Maryland) |
| ABSTRACT | Techniques for radiomics standardization for patient scan data obtained by a particular imaging device are presented. The techniques include acquiring, using the particular imaging machine, the patient scan data; obtaining unstandardized radiomics for the patient scan data; recovering standardized radiomics for the patient scan data based on at least: the patient scan data, the unstandardized radiomics for the patient scan data, and calibration phantom data for the particular machine obtained using at least one calibration phantom; and outputting the standardized radiomics. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 18/255630 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/583 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240104741 | Abramoff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Abramoff (University Heights, Iowa); Milan Sonka (Coralville, Iowa) |
| ABSTRACT | Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional glaucoma damage from retinal optical coherence image data. In an aspect, the systems and methods can map regions and layers of the eye to determine structural characteristics to compare to functional characteristics. |
| FILED | Wednesday, November 29, 2023 |
| APPL NO | 18/522805 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/102 (20130101) A61B 3/1225 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) Original (OR) Class G06T 2207/10101 (20130101) G06T 2207/30041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240104797 | Gong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao Gong (Rochester, Minnesota); Shuai Leng (Rochester, Minnesota); Cynthia H McCollough (Byron, Minnesota) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for material decomposition and virtual monoenergetic imaging from multi-energy computed tomography data are provided. In some embodiments, a system comprises: at least one hardware processor configured to: receive a multi-energy computed tomography (MECT) image of a subject; provide the MECT data to a trained convolutional neural network (CNN); receive output from the trained CNN indicative of predicted material mass density for each of a plurality of materials at each pixel location of the MECT data, wherein the plurality of materials includes at least four materials; and generate a transformed version of the MECT data using the output. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 18/255007 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 11/005 (20130101) Original (OR) Class G06T 11/008 (20130101) G06T 2211/408 (20130101) G06T 2211/441 (20230801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105281 | Chabon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Jacob J. Chabon (Arvada, Colorado); David M. Kurtz (San Carlos, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, nucleic acid molecules, such as cell-free nucleic acids, can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and/or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed. |
| FILED | Friday, August 18, 2023 |
| APPL NO | 18/452463 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6813 (20130101) C12Q 1/6886 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) Original (OR) Class G16B 25/00 (20190201) G16B 25/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105303 | Auslander et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Noam Auslander (Philadelphia, Pennsylvania); Andrew Patterson (Philadelphia, Pennsylvania) |
| ABSTRACT | Described are systems and methods of predicting a response to a medical treatment in a subject. The systems and methods include the steps of selecting a set of mutations within at least one biological process, training a set of classifiers from the set of selected mutations via a training dataset, determining the performance level of each classifier via a validation dataset, applying a subset of high-performance level classifiers from the validation dataset via a test dataset, and predicting the response to the medical treatment based on the test dataset. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/469813 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240099584 | Maharbiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Okland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michel M. Maharbiz (El Cerrito, California); Jose M. Carmena (Berkeley, California); Mekhail Anwar (San Francisco, California); Kristofer S.J. Pister (Oakland, California); Stefanie V. Garcia (Oakland, California) |
| ABSTRACT | Described herein is an implantable device comprising a radiation-sensitive element (such as a transistor) configured to modulate a current as a function of radiation exposure to the transistor; and an ultrasonic device comprising an ultrasonic transducer configured to emit an ultrasonic backscatter that encodes the radiation exposure to the transistor. Further described herein is an implantable device comprising a radiation-sensitive element (such as a diode) configured to generate an electrical signal upon encountering radiation; an integrated circuit configured to receive the electrical signal and modulate a current based on the received electrical signal; and an ultrasonic transducer configured to emit an ultrasonic backscatter based on the modulated current encoding information relating to the encountered radiation. Further described are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also describe are computer systems for operating implantable devices, methods of detecting radiation, methods of treating a solid cancer in a subject, and methods of monitoring a subject for recurrence of a solid cancer. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/244174 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0031 (20130101) Original (OR) Class A61B 5/076 (20130101) A61B 5/279 (20210101) A61B 5/686 (20130101) A61B 6/4258 (20130101) A61B 8/48 (20130101) A61B 8/085 (20130101) A61B 8/0808 (20130101) A61B 8/0875 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 39/0208 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3605 (20130101) A61N 1/3787 (20130101) A61N 1/37205 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240099614 | Galagan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | James Galagan (Needham, Massachusetts); Uros Kuzmanovic (Brookline, Massachusetts); Abdurrahman Addokhi (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor. |
| FILED | Wednesday, September 06, 2023 |
| APPL NO | 18/462190 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1451 (20130101) A61B 5/1477 (20130101) A61B 5/1486 (20130101) A61B 5/14517 (20130101) A61B 5/14546 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240099801 | Lowery et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Allison Lowery (Huber Heights, Ohio); Peter Voland (Beavercreek, Ohio); Nathan Stover (XENIA, Ohio); Gregory M. Burnett (Dayton, Ohio) |
| ABSTRACT | A protective assembly for medical devices that includes a case having a case base and a case lid, at least one case hinge joins the case base to the case lid, a mounting system contained within the case base. The mounting system further including an enclosure attachment system movably attached to a hardware attachment system by a front rotating pin connector and at least one lockable hardware attachment support. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/954022 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 50/31 (20160201) Original (OR) Class A61B 2050/311 (20160201) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 25/108 (20130101) B65D 43/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100049 | Du |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Du (Bethesda, Maryland) |
| ABSTRACT | Provided herein are methods for treating β-globinopathies, such as sickle cell disease and β-thalassemia, by inducing fetal hemoglobin expression and/or embryonic hemoglobin expression. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 18/274565 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240100079 — METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS IN THE INNER EAR OF ADULT MAMMALS
| US 20240100079 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zheng-Yi Chen (Chestnut Hill, Massachusetts); Yi-Zhou Quan (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods for regenerating hair cells in an adult mammalian inner ear using novel combinations of agents selected from the group consisting of a histone deacetylase (HDAC) inhibitor, one or more inhibitory nucleic acids targeting Fir, Mxi1, Fbxw7, or a combination thereof, a Wnt pathway activator, and a cAMP activator. The methods and compositions can be used to treat a subject with hearing loss or vestibular dysfunction. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/275146 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 31/18 (20130101) A61K 31/19 (20130101) A61K 31/166 (20130101) A61K 31/352 (20130101) A61K 31/713 (20130101) Original (OR) Class A61K 33/14 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100767 | LEWIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Jennifer A. LEWIS (Cambridge, Massachusetts); Mark A. Skylar-Scott (Brookline, Massachusetts); Jochen Mueller (Dornhan, Germany) |
| ABSTRACT | In one aspect, the present disclosure provides a nozzle for a 3D printing system. The nozzle may include a flowpath with a material inlet and a material outlet. The nozzle may further include a valve in fluid communication with the flowpath between the material inlet and the material outlet, where the valve includes a closed state and an open state, where in the closed state the valve obstructs the flowpath between the material inlet and the material outlet, and where in the open state the material inlet is in fluid communication with the material outlet. The nozzle may further include a compensator in fluid communication with the flowpath, where the compensator includes a contracted state associated with the open state of the valve and an expanded state associated with the closed state of the valve. |
| FILED | Wednesday, September 06, 2023 |
| APPL NO | 18/462180 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/02 (20190201) B29C 48/05 (20190201) B29C 48/92 (20190201) B29C 48/255 (20190201) B29C 48/298 (20190201) B29C 48/304 (20190201) B29C 48/2888 (20190201) B29C 64/106 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/321 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101525 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loon-Seng Tan (Centerville, Ohio); Zhenning Yu (Beavercreek, Ohio) |
| ABSTRACT | Applicants disclose a family of rod-like dianhydrides that contain two phthalic anhydride moieties linked by a bridge that is comprised of at least one ethynyl and one paraphenylene group and processes of making and using such rod-like dianhydrides. Such rod-like dianhydrides can endow net-work structures with improved mechanical and thermal properties in the crosslinked-polymer products. |
| FILED | Wednesday, April 12, 2023 |
| APPL NO | 18/299092 |
| CURRENT CPC | Heterocyclic Compounds C07D 307/89 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101606 | Chong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lucy S. Chong (Pasadena, California); Ronghui Zhu (Pasadena, California); Xiaofei Ge (Beijing, China PRC); Michael B. Elowitz (Pasadena, California); Mark W. Budde (Arcadia, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments. |
| FILED | Thursday, May 11, 2023 |
| APPL NO | 18/316102 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101632 | BHATNAGAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Parijat BHATNAGAR (Menlo Park, California); Sherri NEWMYER (Menlo Park, California) |
| ABSTRACT | An example genetically engineered electrically-stimulated (ES) cell comprises an exogenous polynucleotide sequence that includes an electrical-sensor element, an actuator element, and an effector element. The electrical-sensor element encodes a voltage-gated calcium ion channel (CaV), wherein the CaV is configured to transition from a closed state to an open state in response to stimulation. The actuator element encodes a transcription factor binding site that upregulates synthesis of an effector protein. The effector element encodes the effector protein, wherein, in response to the transition of the CaV to the open state, the genetically engineered ES effector cell is configured to activate and, to synthesize and secrete the effector protein. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 18/274255 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 41/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/555 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101645 | KREBS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland); THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shelly KREBS (Silver Spring, Maryland); Kayvon MODJARRAD (Silver Spring, Maryland); Nelson MICHAEL (Silver Spring, Maryland); Vincent DUSSUPT (Silver Spring, Maryland); Gina C. DONOFRIO (Silver Spring, Maryland); Samantha TOWNSLEY (Silver Spring, Maryland) |
| ABSTRACT | The present disclosure is directed to monoclonal antibodies, or antigen-binding fragments thereof, that bind to coronavirus spike proteins, including the spike protein of SARS-CoV-2. These antibodies demonstrate high affinity binding to epitopes on the coronavirus spike protein and/or broad cross-reactivity to the spike protein of various coronaviruses. Compositions comprising the anti-coronavirus antibodies, nucleic acids encoding for the antibodies, recombinant expression vectors, and host cells are also disclosed. The present disclosure is also directed to methods of diagnosing, preventing or treating coronavirus infections, including infections or disease caused by SARS-CoV-2. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/273309 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Peptides C07K 16/1003 (20230801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101649 | KLEMPNER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark S.J. KLEMPNER (Boston, Massachusetts); Yang WANG (Wellesley, Massachusetts); Serena GIUNTINI (Belmont, Massachusetts) |
| ABSTRACT | The invention provides anti-CfaE antibodies and methods of using the same. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/481440 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/1232 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101685 | Kobayashi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human (Baltimore, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| INVENTOR(S) | Hisataka Kobayashi (Laurel, Maryland); Peter Choyke (Rockville, Maryland) |
| ABSTRACT | Provided herein are methods of treating a subject with cancer using a therapeutically effective amount of one or more one or more tumor-specific antibody-IR700 molecules. The methods can further include administering to the subject a therapeutically effective amount of (a) one or more CTLA4 antibody-IR700 molecules, one or more PD-L1 antibody-IR700 molecules, or combinations thereof, (b) one or more reducing agents, (c) one or more immunoactivators, or combinations of a, b, and c, for example, either simultaneously or substantially simultaneously with the tumor-specific antibody-IR700 molecules, or sequentially (for example, within about 0 to 24 hours). The method also includes irradiating the subject or cancer cells in the subject (for example, a tumor or cancer cells in the blood) at a wavelength of 660 to 740 nm at a dose of at least 1 J/cm2. The use of one or more reducing agents can reduce edema resulting from treatment. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 18/263394 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7004 (20130101) A61K 39/3955 (20130101) A61K 2039/507 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0616 (20130101) A61N 2005/0659 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 16/2884 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101695 | PENICHET et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Manuel L. PENICHET (Los Angeles, California); Pierre V. CANDELARIA (Los Angeles, California); Miguel NAVA (Los Angeles, California); Tracy R. WELLS (Los Angeles, California) |
| ABSTRACT | Aspects of the disclosure relate to antibodies and methods of use. Various antibodies are disclosed, including engineered antibodies targeting CD138, CD38, and TfR1. Certain aspects are directed to IgE antibodies and use in diagnosis and/or treatment of cancer. Also disclosed are kits and pharmaceutical compositions comprising one or more engineered antibodies. |
| FILED | Wednesday, September 01, 2021 |
| APPL NO | 18/043554 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101724 | Moore et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Levi Michael Joseph Moore (Lancaster, California); Jacob C. Marcischak (Tehachapi, California); Timothy S. Haddad (Lancaster, California); Kamran B. Ghiassi (Palmdale, California); Gregory R. Yandek (Tehachapi, California) |
| ABSTRACT | The present invention relates to articles comprising crosslinked polymer network comprising thioether crosslinks and process of making and using same. Such thiol-ene crosslinking reactions not only make the isocyanate crosslinking reaction unnecessary, but they also improve the article's strength due to chemical crosslinking between the article's resin layers, and reduce or eliminate post curing. Thus resulting in a sufficiently cured article in a much shorter time. |
| FILED | Thursday, November 30, 2023 |
| APPL NO | 18/524592 |
| CURRENT CPC | Treatment or Chemical Modification of Rubbers C08C 19/20 (20130101) C08C 19/28 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 9/06 (20130101) C08L 11/00 (20130101) C08L 2312/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101782 | Byers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffery Byers (Newton, Massachusetts); Connor Gallin (Yonkers, New York) |
| ABSTRACT | The disclosure provides compositions comprising a polymer, a Lewis acid, and a solvent and methods of using the same for ring closing depolymerization of polymers. |
| FILED | Tuesday, August 22, 2023 |
| APPL NO | 18/453763 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/16 (20130101) Original (OR) Class C08J 2335/02 (20130101) C08J 2369/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101785 | Gurtowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luke A Gurtowski (Clinton, Mississippi); Christopher S Griggs (Vicksburg, Mississippi); Sarah Grace Zetterholm (Clinton, Mississippi); Jose A Mattei-Sosa (Vicksburg, Mississippi) |
| ABSTRACT | A chitosan-graphene (CSG) composite material and methods of making the composite material are provided. The CSG composite material is useful for removing microorganisms such as cyanobacteria and blue-green algae from water contaminated with a harmful algal bloom (HAB). The CSG composite material can also remove algal toxins such as microcystins from HAB contaminated water. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953326 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/50 (20130101) C02F 2303/04 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2305/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/042 (20170501) Original (OR) Class Compositions of Macromolecular Compounds C08L 5/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101948 | OH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as Represented by The Secretary of the Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seung J. OH (Champaign, Illinois); Tanner J. Wood (Mahomet, Illinois) |
| ABSTRACT | A 3D bioprinter having a visible light source to photocure biomaterial is disclosed. The 3D bioprinter prints visible light-curable biomaterial along with viable cells, and visible light photocures the biomaterial while maintaining cell viability. Visible light 3D bioprinter systems and methods of printing are further disclosed. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/955463 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 25/02 (20130101) C12M 33/04 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/098 (20200101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101969 | Gradinaru et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viviana Gradinaru (Pasadena, California); Nicholas C. Flytzanis (Thousand Oaks, California); Nicholas S. Goeden (Thousand Oaks, California) |
| ABSTRACT | Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms showing increased specificity and efficiency of viral transduction in targeted cell types such as the brain and lung. The rAAV compositions described herein also have tropisms showing decreased specificity and decreased efficiency of viral transduction in an off-target cell type such as the liver. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. Upon systemic delivery to a subject, the rAAV is capable of increased specificity and increased transduction of the transgene in a target cell-type, as compared to a parental or reference AAV. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503972 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2750/14071 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101997 | Tian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bozhi Tian (Chicago, Illinois); Lingyuan Meng (Chicago, Illinois); Pengju Li (Chicago, Illinois); Wen Li (Chicago, Illinois) |
| ABSTRACT | The present disclosure provides a device and method for a scalable production of extracellular vesicles (EVs) by electrical stimulation. Also provided herein is a composition comprising the EVs loaded with or without therapeutic agents and the method of using this composition for treating diseases. |
| FILED | Wednesday, September 13, 2023 |
| APPL NO | 18/466204 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 35/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102023 | Zhang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Xiaoting Zhang (Mason, Ohio) |
| ABSTRACT | The present disclosure concerns RNA aptamers that specifically inhibit the protein-protein interaction between MED1 and an estrogen receptor. As shown herein, the aptamers are specific for the LXXLL recognition motif between MED 1 and an estrogen receptor. The present disclosure further concerns pRNA nanoparticles of the RNA aptamers coupled with a further HER2 aptamer that show HER2 specific uptake and subsequent inhibition of cellular proliferation and metastasis in vitro and in vivo. Furthermore, the pRNA nanoparticles showed no adverse effects, signifying a safe and effective composition to specifically target and control HER2 expressing cells. |
| FILED | Wednesday, October 14, 2020 |
| APPL NO | 17/768023 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class C12N 2310/335 (20130101) C12N 2310/3517 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102115 | Sabeti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pardis Sabeti (Cambridge, Massachusetts); Cameron Myhrvold (Cambridge, Massachusetts); Jon Arizti Sanz (Cambridge, Massachusetts); Alexandra Stanton (Cambridge, Massachusetts); Brittany Petros (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are compositions and methods of CRISPR effector system mediated detection of targets, including, but not limited to viral targets. Also described herein are devices and kits for carrying out the CRISPR effector system mediated nucleic acid detection assays. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 18/023538 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54388 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102320 | Hollen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith Ryan Hollen (Saint Charles, Missouri); Nathan Matthew Knibb (Manchester, Missouri); Perry T. Horst (Tacoma, Washington); Jonathan David Gettinger (Imperial, Missouri); Alexander McGregor (St. Louis, Missouri); Everett Ryan Eaton (Saint Charles, Missouri); Michael L. Oleshchuk (Saint Charles, Missouri); Sean Craig Sundberg (Saint Charles, Missouri); Angel Rodriguez (Saint Charles, Missouri) |
| ABSTRACT | A wing lock and deployment apparatus for an air launched vehicle includes a driver acted on by a single linear actuation event. The disclosed wing lock and deployment apparatus is capable of unlocking deployable wings of an air launched vehicle, deploying deployable wings of the air launched vehicle from a stored position, and locking deployable wings of the air launched vehicle in a deployed position in sequential order with the one single linear actuation event. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936079 |
| CURRENT CPC | Locks; Accessories Therefor; Handcuffs E05B 65/00 (20130101) Original (OR) Class Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 10/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102439 | Son et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Steven Forrest Son (West Lafayette, Indiana); Kyle Uhlenhake (Lafayette, Indiana); Diane Collard (West Lafayette, Indiana); Mateo Gomez (West Lafayette, Indiana) |
| ABSTRACT | An igniter system and method for igniting a propellant by an optical energy source. The igniter system including an igniter composite and a propellant. The igniter composite including a reactive component and a fluoropolymer. The propellant is coupled to the igniter composite. The igniter composite has a composition including nano-aluminum at ideal stoichiometry in polyvinylidene fluoride. The igniter composite is configured to achieve a sustained ignition from a wavelength emitted from the optical energy source. The wavelength is between around 250 nanometers to around 1100 nanometers. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/527230 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Jet-propulsion Plants F02K 9/95 (20130101) Ignition, Other Than Compression Ignition, for Internal-combustion Engines; Testing of Ignition Timing in Compression-ignition Engines F02P 23/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102805 | Sabater |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Jose, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Andrew B. Sabater (San Diego, California) |
| ABSTRACT | A single body multi-mode mechanical resonator includes two or more spring-mass devices, one or more anchor springs, a phase 1 parallel plate electrode and a phase 2 parallel plate electrode, a plurality of interdigitated shaped combs, a plurality of interdigitated drive combs, and a plurality of interdigitated sense combs. The spring-mass devices further include two or more lumped masses and one or more anchor springs. The coupling springs couple the motion of the two or more lumped masses. The parallel plate electrodes apply forces to the in-phase mode that yield equal in magnitude but opposite in sign frequency shifts of the anti-phase mode. The shaped combs compensate for a frequency drift of the anti-phase mode and cancels first-order displacement effects. The drive combs are aligned to the anti-phase mode, with a frequency selective excitation. The sense combs are aligned to the anti-phase mode and capable of cancelling common-mode noise effects. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950206 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/574 (20130101) G01C 19/5726 (20130101) Original (OR) Class Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102991 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuedong Liu (Niwot, Colorado); Douglas A. Chapnick (Boulder, Colorado); William Old (Boulder, Colorado); Tristan D. Mcclure-Begley (Falls Church, Virginia); Eric Bunker (Derwood, Maryland) |
| ABSTRACT | Provided are FRET-based biosensor constructs, and multiplexed platforms or arrays of these biosensor constructs useful for screening candidate drug molecules for efficacy and/or specificity of drug activity. Optionally the biosensor constructs may be located on an inner membrane within a cell or engineered to be located on the cell's surface. The cells or cell lines displaying the biosensors on a cell surface may be arranged as an array of cells for high throughput evaluation of the efficacy and/or specificity of drug candidates, such as a library of candidate drug compounds. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/386764 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 2300/0636 (20130101) Apparatus for Enzymology or Microbiology; C12M 1/3476 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 2500/00 (20130101) C12Q 2560/00 (20130101) C12Q 2563/107 (20130101) C12Q 2563/179 (20130101) C12Q 2565/1015 (20130101) C12Q 2600/136 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 21/6428 (20130101) G01N 21/6452 (20130101) G01N 33/542 (20130101) G01N 33/554 (20130101) G01N 33/582 (20130101) G01N 33/5008 (20130101) Original (OR) Class G01N 2500/04 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103130 | Clymer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley J. Clymer (Austin, Texas) |
| ABSTRACT | An example radar target classification system for identifying classes of objects includes a cluster engine includes processing circuitry and configured to process radar data to determine a cluster of radar detections, the radar data being based on radio waves reflected from one or more objects over a time window. The example system includes a feature extraction engine comprising processing circuitry and configured to determine a plurality of statistical features based on the determined cluster of radar detections. The example system includes a classifier comprising processing circuitry and configured to classify a first object of the one or more objects based on the determined plurality of statistical features and to output an indication of a class of the first object. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 18/250933 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/411 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103306 | HAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| INVENTOR(S) | Sang Eon HAN (Albuquerque, New Mexico); Sang M. HAN (Albuquerque, New Mexico); James GILCHRIST (Orefield, Pennsylvania); Jinghui GAO (Bethlehem, Pennsylvania); Samuel WILSON-WHITFORD (Leicester, United Kingdom) |
| ABSTRACT | Suspensions of magneto-responsive Janus colloids form chains and undergo alignment under the influence of a magnetic field. When the magnetic field is aligned with a light path, light transmission through the sample increases as compared to randomly or orthogonally oriented chains. The emissivity response of this suspension is presented as a function of particle concentration and magnetic field strength. A variation of the Beer-Lambert model and ray-tracing simulations capture the behavior of the experimentally measured difference in intensity between magnetically activated and non-activated Brownian suspensions. Experiments demonstrate up to 25% contrast in transmission of visible light, which may be further optimized through materials selection. Similar experiments when these Janus particle chains are suspended in carbon tetrachloride, demonstrate an emissivity variation in the near infrared of ˜10%. |
| FILED | Thursday, September 21, 2023 |
| APPL NO | 18/370954 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/094 (20210101) Original (OR) Class G02F 1/0121 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103908 | CHAKRABARTI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin); UNIVERSITY OF ARIZONA (Tucson, Arizona); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin); UNIVERSITY OF ARIZONA (Tucson, Arizona); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Chaitali CHAKRABARTI (Tempe, Arizona); Umit OGRAS (Madison, Wisconsin); Ahmet GOKSOY (Madison, Wisconsin); Anish KRISHNAKUMAR (Madison, Wisconsin); Ali AKOGLU (Tucson, Arizona); Md Sahil HASSAN (Scottsdale, Arizona); Radu MARCULESCU (Austin, Texas); Allen-Jasmin FARCAS (Austin, Texas) |
| ABSTRACT | Provided herein are dynamic adaptive scheduling (DAS) systems. In some embodiments, the DAS systems include a first scheduler, a second scheduler that is slower than the first scheduler, and a runtime preselection classifier that is operably connected to the first scheduler and the second scheduler, which runtime preselection classifier is configured to effect selective use of the first scheduler or the second scheduler to perform a given scheduling task. Related systems, computer readable media, and additional methods are also provided. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470177 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/54 (20130101) G06F 9/4881 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240104221 | Saieva et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Anthony Saieva (New York, New York); Frederico Araujo (Mahopac, New York); Sanjeev Das (White Plains, New York); Michael Vu Le (Danbury, Connecticut); Jiyong Jang (Chappaqua, New York) |
| ABSTRACT | A method to test an OS kernel interface, such as an eBPF helper function. The interface has a grammar that defines the kernel interface. Testing is carried out using eBPF code that invokes and tests the interface using a fuzzing engine. To facilitate the process, additional user space code is configured to generate at least one kernel event that triggers the eBPF code to run, and to transform inputs from the fuzzing engine according to the grammar that defines the kernel interface. After loading the eBPF code into the OS kernel, the user space code issues the kernel event that causes the eBPF code to run. In response, and as the fuzzing engine executes, the eBPF code records arguments sent to the OS kernel through the kernel interface. The arguments are passed through a data structure shared by the eBPF code and the user space code. By recording the arguments and other diagnostic information, the security of the kernel interface is evaluated. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/952189 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/577 (20130101) Original (OR) Class G06F 2221/034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240104386 — RADIO SIGNAL IDENTIFICATION, IDENTIFICATION SYSTEM LEARNING, AND IDENTIFIER DEPLOYMENT
| US 20240104386 | O`Shea |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy James O`Shea (Arlington, Virginia) |
| ABSTRACT | Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned identification of radio frequency (RF) signals. One of the methods includes: determining an RF signal configured to be transmitted through an RF band of a communication medium; determining first classification information that is associated with the RF signal, and that includes a representation of a characteristic of the RF signal or a characteristic of an environment in which the RF signal is communicated; using at least one machine-learning network to process the RF signal and generate second classification information as a prediction of the first classification information; calculating a measure of distance between (i) the second classification information that was generated by the at least one machine-learning network, and (ii) the first classification information associated with the RF signal; and updating the at least one machine-learning network based on the measure of distance. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/376480 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/045 (20230101) G06N 3/086 (20130101) Original (OR) Class G06N 20/00 (20190101) Transmission H04B 17/30 (20150115) Wireless Communication Networks H04W 24/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240104583 | Chandrakasan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anantha Chandrakasan (Cambridge, Massachusetts); Benedetto Marelli (Cambridge, Massachusetts); Hui Sun (Cambridge, Massachusetts); Saurav Maji (Cambridge, Massachusetts) |
| ABSTRACT | Compositions are provided that include a first product with a physical unclonable function (PUF) tag including silk particles conformably and directly attached to the first product, wherein the PUF tag cannot be reattached to a second product once removed from the first product. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/358271 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0185 (20130101) Original (OR) Class G06Q 50/02 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240104681 | Kishore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Varsha Kishore (Ithaca, New York); Kilian Weinberger (Ithaca, New York); Xiangyu Chen (Ithaca, New York); Boyi Li (New York, New York); Yan Wang (Ithaca, New York); Ruihan Wu (Ithaca, New York) |
| ABSTRACT | A method performed by at least one processing device in an illustrative embodiment comprises applying a first image and a message to an encoder of a steganographic encoder-decoder neural network, generating in the encoder, based at least in part on the first image and the message, a perturbed image containing the message, decoding the perturbed image in a decoder of the steganographic encoder-decoder neural network, and providing information characterizing the decoded perturbed image to the encoder. The generating, decoding and providing are iteratively repeated, with different perturbations being determined in the encoder as a function of respective different instances of the provided information, until the decoded perturbed image meets one or more specified criteria relative to the message. The perturbed image corresponding to the decoded perturbed image that meets the one or more specified criteria relative to the message is output as a steganographic image containing the message. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 18/557361 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0442 (20230101) G06N 3/0455 (20230101) Image Data Processing or Generation, in General G06T 1/005 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 40/16 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240104842 | Nagano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NVIDIA Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Koki Nagano (Playa Vista, California); Alexander Trevithick (Mamaroneck, New York); Chao Liu (Pittsburgh, Pennsylvania); Eric Ryan Chan (Alameda, California); Sameh Khamis (Alameda, California); Michael Stengel (Hayward, California); Zhiding Yu (Santa Clara, California) |
| ABSTRACT | A method for generating, by an encoder-based model, a three-dimensional (3D) representation of a two-dimensional (2D) image is provided. The encoder-based model is trained to infer the 3D representation using a synthetic training data set generated by a pre-trained model. The pre-trained model is a 3D generative model that produces a 3D representation and a corresponding 2D rendering, which can be used to train a separate encoder-based model for downstream tasks like estimating a triplane representation, neural radiance field, mesh, depth map, 3D key points, or the like, given a single input image, using the pseudo ground truth 3D synthetic training data set. In a particular embodiment, the encoder-based model is trained to predict a triplane representation of the input image, which can then be rendered by a volume renderer according to pose information to generate an output image of the 3D scene from the corresponding viewpoint. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472653 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/20 (20130101) G06T 7/70 (20170101) G06T 7/90 (20170101) G06T 17/00 (20130101) Original (OR) Class G06T 2207/10024 (20130101) Image or Video Recognition or Understanding G06V 10/771 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105781 | Heller |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Eric Heller (Kettering, Ohio) |
| ABSTRACT | A gallium oxide field effect transistor that is built on a base layer. A doped gallium oxide channel layer is disposed on top of the base layer, and a dielectric barrier layer is disposed on top of the gallium oxide channel layer. Source contacts and drain contacts are disposed on top of the dielectric barrier layer, with one each of the drain contacts disposed in an interdigitated manner between one each of the source contacts. The interdigitated source contacts and drain contacts thereby define channels between them, where alternating ones of the channels are defined as odd channels, with even channels disposed therebetween. Gate contacts are disposed on top of the dielectric barrier layer in only one of the odd channels and the even channels. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/531801 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) Original (OR) Class H01L 29/0696 (20130101) H01L 29/41758 (20130101) H01L 29/42356 (20130101) H01L 29/66969 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105913 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Navitas Systems, LLC (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pu Zhang (Ann Arbor, Michigan); Michael Wixom (Ann Arbor, Michigan); Robert Sosik (Ann Arbor, Michigan) |
| ABSTRACT | Provided are electrodes that include an electrode dry mixture and a dry electrolyte material intermixed with the electrode dry mixture; and a binder intermixed with the electrode dry mixture and the dry electrolyte material, said binder comprising fibrils; the electrode dry mixture, dry electrolyte material, and said binder in the form of a dry electrode film. The electrolyte material may include a glass ceramic and, optionally, an air-stabilizing dopant. The glass ceramic may include Li3PS4. The electrodes may include a composite cathode of the dry electrode film and optionally further include a solid-state electrolyte layer. Also provided are methods for forming the electrodes, optionally where the methods may be applicable for a solvent-free process to form electrodes and electrochemical cells and batteries including the electrodes. |
| FILED | Wednesday, November 29, 2023 |
| APPL NO | 18/523159 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/043 (20130101) H01M 4/134 (20130101) H01M 4/366 (20130101) H01M 4/382 (20130101) H01M 4/628 (20130101) H01M 4/1395 (20130101) Original (OR) Class H01M 10/052 (20130101) H01M 10/0562 (20130101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240106452 | Whitcombe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Amy Whitcombe (Saratoga, California); Brent R. Carlton (Portland, Oregon); Sundar Krishnamurthy (Dublin, California); Deepak Dasalukunte (Beaverton, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amy Whitcombe (Saratoga, California); Brent R. Carlton (Portland, Oregon); Sundar Krishnamurthy (Dublin, California); Deepak Dasalukunte (Beaverton, Oregon) |
| ABSTRACT | A converter can include a number of time-to-voltage converters (TVCs) each receiving an input time-domain signal. The input time-domain signal can represent a different sample than input time-domain signals of the other TVCs. The converter can also include a capacitive element coupled to outputs of the TVCs to receive a combined output signal of the TVCs. The capacitive element can provide an input capacitance of an analog-to-digital converter (ADC). Other methods and apparatuses are described. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/955186 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 1/38 (20130101) Original (OR) Class H03M 1/1245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240107304 | Hayden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Blake Alexander Hayden (Canton, South Dakota); Britta Jean Hale (Monterey, California) |
| ABSTRACT | Methods and systems for reduced file transfer protocols are disclosed, Provided are methods and systems for implementation for securing software updates to satellites and remote locations under power, bandwidth, or frequency limitations, using cryptographic protocols for different components of a delivery architecture for a large data payload, such as for a software update, from a trusted, back-end (terrestrial) source to receivers: a low-response protocol for initial transmission and confirmation (BAC protocol), and two possible inter-unit distribution protocols (COCO-SYNC-R protocol (Pull) or COCO-SYNC-P (PUSH)) with differing optimizations based on connectivity scenarios. These protocols introduce a means for accounting for both security (authentication) and efficacy (minimized RF footprint) in the delivery of critical data payloads to remote receivers. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/369664 |
| CURRENT CPC | Wireless Communication Networks H04W 12/06 (20130101) Original (OR) Class H04W 12/106 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240099952 | Cao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MAGIC BLUE, LLC (Bethesda, Maryland); UNIVERSITY OF MARYLAND (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kan Cao (Bethesda, Maryland); Chandamany Arya (Ellicot City, Maryland); Jasmin El Kordi (Vienna, Virginia) |
| ABSTRACT | A sunscreen composition, containing an effective amount of Methylene Blue and/or a hydrate and or a pharmaceutically-acceptable salt thereof; an effective amount of one or more UVA and/or UVB absorbing compounds, with the proviso that Oxybenzone and Octinoxate are excluded; and an excipient base. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/766598 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/0229 (20130101) A61K 8/4926 (20130101) Original (OR) Class A61K 2800/30 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100030 | Zhang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Chunhua Zhang (West Lafayette, Indiana) |
| ABSTRACT | In one embodiment, the present application relates to methods and materials for weed control of a field of a crop plant using a cellulose biosynthesis inhibitor selected from the group consisting of ES20 and ES20-1 to ES20-9 of FIG. 1A. In another embodiment, the present disclosure relates to a method for treatment or prevention of an infection through inhibition of biofilm formation of microorganisms comprising the step of applying a therapeutic effective amount of a cellulose biosynthesis inhibitor selected from the group consisting of ES20 and ES20-1˜ES20-9 of FIG. 1A, or a salt thereof, in combination with one or more other commonly used antibiotics. A composition matter comprising said compounds and methods of use are within the scope of the present invention. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/531281 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 47/30 (20130101) A01N 47/34 (20130101) A01N 47/36 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/44 (20130101) Original (OR) Class A61K 31/381 (20130101) A61K 45/06 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/16 (20130101) A61L 2/0082 (20130101) A61L 2101/40 (20200801) A61L 2202/24 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100218 | Pei et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Qibing Pei (Los Angeles, California); Meng Gao (Los Angeles, California); Hanxiang Wu (Los Angeles, California); Zhixin Xie (Los Angeles, California) |
| ABSTRACT | A composition of matter useful as a bioadhesive including a bistable adhesive polymer. The bistable adhesive polymer includes one or more polymer backbones; side-chains attached to each of the polymer backbones; and one or more transition temperatures between a crystalline state and an amorphous state. The one or more transition temperatures are such that the polymer transitions from the crystalline state to the amorphous state upon physical contact with biological tissue having a temperature higher than the transition temperature. The polymer adheres or attaches to the biological tissue in the amorphous state and can be peeled from the biological tissue when cooled below the transition temperature to the crystalline state. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 18/263315 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/06 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/1818 (20200201) C08F 222/22 (20130101) C08F 2810/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100334 | Humayun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark S. Humayun (Los Angeles, California); Gianluca Lazzi (Los Angeles, California); Bodour Salhia (Los Angeles, California); Manjunath Machnoor (Los Angeles, California); Javad Paknahad (Los Angeles, California) |
| ABSTRACT | Methods, systems, and apparatus for causing changes to cells or tissue within or adjacent to an eye. The system includes an external RF coil configured to transmit RF signals. The system also includes a wearable device configured to be removably disposed on the eye, the wearable device including a plurality of internal radiofrequency (RF) coils configured to receive the RF signals from the external RF coil and a plurality of stimulating electrodes configured to electromagnetically stimulate a portion of the eye or an area adjacent to the eye, causing changes to cells or tissue within or adjacent to the eye. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/766600 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/40 (20130101) A61N 1/0476 (20130101) A61N 1/36014 (20130101) A61N 1/36046 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100485 | Wiesner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ulrich B. Wiesner (Ithaca, New York); Yusuke Hibi (Shizuoka, Japan) |
| ABSTRACT | Asymmetric films, methods of making asymmetric films, and uses of asymmetric films. A method may include using at least two different solvents and at least one homopolymer and at least one block copolymer that can undergo self assembly, where the solvents are immiscible and have different surface tension, where, on film formation, all or substantially all of the block copolymer(s) migrate to an exterior surface of the homopolymer. The asymmetric films may include an isoporous region or layer and an asymmetric region or layer, where the asymmetric region does not include 10 percent by weight or more of the multiblock copolymer(s) and/or the isoporous region/layer and the asymmetric pore region/layer are not independently (or separately) formed and/or not laminated together to form the asymmetric film. The films can be used in devices, such as, for example, filtration devices. |
| FILED | Saturday, January 22, 2022 |
| APPL NO | 18/262633 |
| CURRENT CPC | Separation B01D 67/00111 (20220801) Original (OR) Class B01D 69/02 (20130101) B01D 71/44 (20130101) B01D 71/68 (20130101) B01D 71/80 (20130101) B01D 71/281 (20220801) B01D 2325/0233 (20220801) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 212/08 (20130101) C08F 226/06 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) C08K 2003/2241 (20130101) C08K 2201/011 (20130101) Compositions of Macromolecular Compounds C08L 53/00 (20130101) C08L 81/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100509 | LIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jinyong LIU (Riverside, California); Jinyu GAO (Riverside, California) |
| ABSTRACT | The invention provides a catalyst comprising 1) Ru0 and 2) Pd0, Pt0, Rh0, or Ir0, on a solid support. The catalyst is useful for water purification applications. In particular, the catalyst is useful for reducing ClO3− and ClO2− from water. The invention also provides catalysts that are useful for reducing nitrate in a water supply and methods for their use. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/372535 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/44 (20130101) B01J 23/462 (20130101) Original (OR) Class Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/705 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100563 | Wyatt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (COLUMBIA, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Quinton K. Wyatt (Columbia, Missouri); Matthias J. Young (Columbia, Missouri); Patrick J. Kinlen (Fenton, Missouri); Nikhila C. Paranamana (Columbia, Missouri) |
| ABSTRACT | Unique polymers and copolymers generated via oMLD processes are described alongside the methods for tuning such polymer and copolymer structures and redox chemistries. The polymers and copolymers described can incorporate monomeric species previously held to have too high an oxidation potential for successful use in oMLD, can exhibit unexpected redox chemistry from the adjustable incorporation of primary amine monomers and resulting azo functional groups, and show superior performance metrics when compared to polymers and copolymers synthesized by other methods. Applications for these polymers and copolymers are also described. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530742 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/36 (20130101) Original (OR) Class B05D 1/60 (20130101) B05D 2504/00 (20130101) B05D 2518/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101617 | Boothby et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Christopher Clark Boothby (Chapel Hill, North Carolina); Robert Patrick Goldstein (Carrboro, North Carolina); Gary Joseph Pielak (Chapel Hill, North Carolina); Samantha Piszkiewicz (Chapel Hill, North Carolina); Alexandra Harrison Brozena (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention relates to methods and compositions for stabilizing proteins. The invention provides compositions comprising at least one tardigrade disordered protein (TDP) and at least one heterologous polypeptide and/or peptide of interest. Further provided are methods for stabilizing proteins and for producing organisms and cells having increased tolerance to desiccation and/or drought. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/513744 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 1/008 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/18 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 47/42 (20130101) Peptides C07K 14/43504 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/74 (20130101) C12N 15/81 (20130101) C12N 15/8273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101726 | Do et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| INVENTOR(S) | Loi H. Do (Manvel, Texas); Thi V. Tran (Houston, Texas) |
| ABSTRACT | This invention relates to nickel catalysts with alkali ions for homopolymerization and copolymerization. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/982767 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/06 (20130101) C08F 4/7098 (20130101) Original (OR) Class C08F 210/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101727 | Do et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| INVENTOR(S) | Loi H. Do (Manvel, Texas); Thi V. Tran (Houston, Texas) |
| ABSTRACT | This invention relates to nickel catalysts with alkali ions for homopolymerization and copolymerization. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/982917 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/06 (20130101) C08F 4/7098 (20130101) Original (OR) Class C08F 210/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101782 | Byers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffery Byers (Newton, Massachusetts); Connor Gallin (Yonkers, New York) |
| ABSTRACT | The disclosure provides compositions comprising a polymer, a Lewis acid, and a solvent and methods of using the same for ring closing depolymerization of polymers. |
| FILED | Tuesday, August 22, 2023 |
| APPL NO | 18/453763 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/16 (20130101) Original (OR) Class C08J 2335/02 (20130101) C08J 2369/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101787 | Bara et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of The University of Alabama (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Edward Bara (Tuscaloosa, Alabama); Amber Renee Bara (Tuscaloosa, Alabama); Shuai Qian (Northport, Alabama) |
| ABSTRACT | The present disclosure describes crosslinking agents derived from glycerol and/or waste poly(ethylene terephthalate) of Formula I and Formula II which may find use in various polymer applications, including as an additive in personal care products. |
| FILED | Monday, August 28, 2023 |
| APPL NO | 18/238684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/85 (20130101) A61K 2800/95 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 5/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/183 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/1565 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 67/02 (20130101) C08L 2207/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101947 | Curtis |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wayne Rodger Curtis (State College, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne Rodger Curtis (State College, Pennsylvania) |
| ABSTRACT | An apparatus for culturing suspended photosynthetic organisms, specifically a flowing thin film photobioreactor, wherein the flowing thin film photobioreactor comprises a light source and a trickle-film insert comprising screen material. |
| FILED | Wednesday, November 22, 2023 |
| APPL NO | 18/518199 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/02 (20130101) C12M 25/00 (20130101) C12M 29/06 (20130101) C12M 31/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102033 | Kaeppler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heidi Kaeppler (Oregon, Wisconsin); Nathaniel Schleif (Madison, Wisconsin) |
| ABSTRACT | The present invention provides constructs comprising a transgene operable linked to a novel tissue-specific maize promoter. Methods of using the constructs to drive tissue-specific transgene expression in a maize plant and maize plants comprising the constructs are also provided. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/473015 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8205 (20130101) C12N 15/8223 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102080 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/536654 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102202 | YU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Abalone Bio, Inc. (Richmond, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard YU (Richmond, California); Carlos Gustavo PESCE (Richmond, California); Rodrigo BALTANÁS (Richmond, California); Brett ROBISON (Richmond, California) |
| ABSTRACT | Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display. |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/243603 |
| CURRENT CPC | Peptides C07K 16/00 (20130101) C07K 16/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) C40B 30/06 (20130101) C40B 40/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102439 | Son et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Steven Forrest Son (West Lafayette, Indiana); Kyle Uhlenhake (Lafayette, Indiana); Diane Collard (West Lafayette, Indiana); Mateo Gomez (West Lafayette, Indiana) |
| ABSTRACT | An igniter system and method for igniting a propellant by an optical energy source. The igniter system including an igniter composite and a propellant. The igniter composite including a reactive component and a fluoropolymer. The propellant is coupled to the igniter composite. The igniter composite has a composition including nano-aluminum at ideal stoichiometry in polyvinylidene fluoride. The igniter composite is configured to achieve a sustained ignition from a wavelength emitted from the optical energy source. The wavelength is between around 250 nanometers to around 1100 nanometers. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/527230 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Jet-propulsion Plants F02K 9/95 (20130101) Ignition, Other Than Compression Ignition, for Internal-combustion Engines; Testing of Ignition Timing in Compression-ignition Engines F02P 23/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102895 | HESKETT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aerosol Devices Inc. (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominick Dalton Reyes HESKETT (Greeley, Colorado); Patricia Bea KEADY (Fort Collins, Colorado) |
| ABSTRACT | The present invention features a device and method for directly collecting airborne particles onto a swab collection substrate. Prior to collection, water vapor may be condensed onto the particles to increase their average diameter. The particles are expelled from one or more acceleration nozzles for gentle impaction onto the swab collection substrate and may be further analyzed through chemical or biological assays. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/275713 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2208 (20130101) G01N 1/2214 (20130101) Original (OR) Class G01N 2001/2282 (20130101) G01N 2001/2285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102901 | Warrick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SALUS DISCOVERY, LLC (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Warrick (Madison, Wisconsin); Cody Carrell (Sun Prairie, Wisconsin); Brianna Mullins (DeForest, Wisconsin); David Beebe (Monona, Wisconsin); Ryan Shogren (Madison, Wisconsin); Patrick McMinn (Madison, Wisconsin); Mitch Geiger (Madison, Wisconsin); Madalyn Gill (Madison, Wisconsin); Jeffrey Robert Staszak (Deerfield, Wisconsin); Visnu Devi Fraenkel (Madison, Wisconsin); Antonio Gatta (Philadelphia, Pennsylvania); Eric S. Mackey (Wales, Wisconsin); McKayla Rae Barber (Madison, Wisconsin); Randi Marie Degg (Seattle, Washington); Madeline Sides (Carmichael, California); Douglas Paul Barnes (Charlotte, North Carolina); Franklin Cheng Zhong (Lee's Summit, Missouri); Mindy Phung (Houston, Texas) |
| ABSTRACT | Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/373110 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4005 (20130101) Original (OR) Class G01N 33/493 (20130101) G01N 2001/4088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102995 | Szczesny et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bartosz Szczesny (Galveston, Texas); Massoud Motamedi (Galveston, Texas); Stefan H. Bossmann (Manhattan, Kansas) |
| ABSTRACT | The present invention relates in general to the field of rapid detection and quantification of tissue/organ injury, and more particularly, to a novel platform for monitoring and quantification of circulating cell-free DNA including within extracellular vesicles, together with extracellular vesicles specific markers, and extracellular vesicles sizes also in combination with PCR-related technologies in biospecimens, and liquid biopsies for the assessment and prediction of severity of tissue/organ injury, monitoring of disease progression as well as the assessment of the response to therapeutic interventions. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468020 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103088 | Chung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rejoule Incorporated (Signal Hill, California) |
| ASSIGNEE(S) | Rejoule Incorporated (Signal Hill, California) |
| INVENTOR(S) | Steven Chung (Stanton, California); Kenny Huynh (Stanton, California); Russell Okamura (Stanton, California) |
| ABSTRACT | An electrochemical storage diagnostic system is configured to perform an electrical test to measure energy storage device parameters. The diagnostic system includes a charge management controller, electrically coupled to a power multiplexer, a power converter circuit, and an isolated converter circuit. The charge management controller is programmed with instructions to identify a device under test, selected from at least one member of the plurality of energy storage devices to perform an electrical test. Then, adjust a charge in the secondary energy storage device to a target voltage through the power multiplexer by transferring energy between the secondary energy storage device and a support device, selected from at least one member of the plurality energy storage devices. After that, transfer electrical power through the power multiplexer and power converter circuit to the device under test in order to perform the electrical test. Finally, complete the electrical test. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/376353 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/364 (20190101) G01R 31/386 (20190101) Original (OR) Class G01R 31/392 (20190101) G01R 31/3842 (20190101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103186 | Kanatzidis et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercouri G. Kanatzidis (Wilmette, Illinois); Michael Anthony Quintero (Evanston, Illinois) |
| ABSTRACT | Lithium-containing thiostannate spinel compounds having the formula Li2M1+xSn3−xS8, where x is 0 or 1 and M is Mg, Fe, Mn, Ni, Ga, In, or a combination thereof; or the formula Li1.66CuSn3.33S8 are provided. Methods and devices for detecting incident neutrons and alpha-particles using the compounds are also provided. For thermal neutron detection applications, the compounds can be enriched with lithium-6 isotope (6Li) to enhance their neutron detecting capabilities. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 18/272852 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 19/006 (20130101) C01G 45/006 (20130101) C01G 53/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/32 (20130101) C01P 2002/60 (20130101) C01P 2002/76 (20130101) C01P 2002/77 (20130101) C01P 2006/60 (20130101) Measurement of Nuclear or X-radiation G01T 1/1606 (20130101) Original (OR) Class G01T 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103859 | Siskind et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH (Maynooth, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Mark Siskind (West Lafayette, Indiana); Barak Avrum Pearlmutter (Dublin, Ireland) |
| ABSTRACT | A system and method which allows the basic checkpoint-reverse-mode AD strategy (of recursively decomposing the computation to reduce storage requirements of reverse-mode AD) to be applied to arbitrary programs: not just programs consisting of loops, but programs with arbitrarily complex control flow. The method comprises (a) transforming the program into a formalism that allows convenient manipulation by formal tools, and (b) introducing a set of operators to allow computations to be decomposed by running them for a given period of time then pausing them, while treating the paused program as a value subject to manipulation. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/494357 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/60 (20130101) G06F 7/544 (20130101) G06F 9/461 (20130101) G06F 9/30036 (20130101) Original (OR) Class G06F 11/36 (20130101) G06F 17/10 (20130101) G06F 17/13 (20130101) G06F 17/17 (20130101) Computer Systems Based on Specific Computational Models G06N 5/01 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240104183 | LIU |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| ASSIGNEE(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| INVENTOR(S) | Jian LIU (Knoxville, Tennessee) |
| ABSTRACT | Provided are methods, apparatus, systems, and computer-readable media for processing biosensor information to produce multi-dimensional images of facial movement, produce multi-dimensional images of expressions of a human user, perform biosensor-based user identification, perform biosensor-based user authentication, and combinations thereof. Other methods, apparatus, systems, and computer-readable media are also disclosed. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/474137 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240104583 | Chandrakasan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anantha Chandrakasan (Cambridge, Massachusetts); Benedetto Marelli (Cambridge, Massachusetts); Hui Sun (Cambridge, Massachusetts); Saurav Maji (Cambridge, Massachusetts) |
| ABSTRACT | Compositions are provided that include a first product with a physical unclonable function (PUF) tag including silk particles conformably and directly attached to the first product, wherein the PUF tag cannot be reattached to a second product once removed from the first product. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/358271 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0185 (20130101) Original (OR) Class G06Q 50/02 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240106087 | Colvin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); Soteria Battery Innovation Group, Inc. (Greenville, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathaniel Colvin (Columbus, Ohio); Avraham Benatar (Columbus, Ohio); Carl Hu (Greenville, South Carolina); Drew Pereira (Greenville, South Carolina); Brian Morin (Greenville, South Carolina) |
| ABSTRACT | Disclosed herein are joining methods (e.g., methods of forming a joined material) and devices comprising materials joined by said methods. For example, the disclosed subject matter related to methods of joining one or more metallized polymer current collectors together and/or to a tab. For example, the methods can comprise: placing one or more metallized polymer current collector proximate a tab, such that at least a portion of the metallized polymer current collector(s) overlaps with at least a portion of the tab in an overlap region; placing a conductive material proximate the overlap region; inducing flow of the conductive material such that the conductive material flows at least between the portion of the metallized polymer current collector(s) and the portion of the tab; and subsequently solidifying the conductive material, thereby forming a joint that joins the metallized polymer current collector(s) to the tab. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/372224 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0016 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/70 (20130101) H01M 4/661 (20130101) H01M 4/667 (20130101) H01M 50/536 (20210101) Original (OR) Class H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240100581 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dalong Zhang (Richland, Washington); Jens T. Darsell (Richland, Washington); Christopher B. Smith (Benton City, Washington); Ayoub Soulami (Richland, Washington); Glenn J. Grant (Benton City, Washington) |
| ABSTRACT | A tool assembly for friction extrusion can comprise a friction extrusion die. The friction extrusion die can include a distal face and a proximal end. The distal face can define at least one topographical ridge or groove feature to induce plasticization of a material in response to an axial force and a rotational force applied by the distal face to the material. The friction extrusion die can define a central passage to carry an extrudate of the material in a proximal direction in response to the applied axial and rotational forces. The proximal end can define a faceted cross-sectional profile to mate a with a corresponding receiving end of a tool holder. The faceted cross-sectional profile can be sized and shaped to receive the rotational force through engagement by the tool holder of respective faces defined by the faceted cross-sectional profile. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/476216 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100767 | LEWIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Jennifer A. LEWIS (Cambridge, Massachusetts); Mark A. Skylar-Scott (Brookline, Massachusetts); Jochen Mueller (Dornhan, Germany) |
| ABSTRACT | In one aspect, the present disclosure provides a nozzle for a 3D printing system. The nozzle may include a flowpath with a material inlet and a material outlet. The nozzle may further include a valve in fluid communication with the flowpath between the material inlet and the material outlet, where the valve includes a closed state and an open state, where in the closed state the valve obstructs the flowpath between the material inlet and the material outlet, and where in the open state the material inlet is in fluid communication with the material outlet. The nozzle may further include a compensator in fluid communication with the flowpath, where the compensator includes a contracted state associated with the open state of the valve and an expanded state associated with the closed state of the valve. |
| FILED | Wednesday, September 06, 2023 |
| APPL NO | 18/462180 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/02 (20190201) B29C 48/05 (20190201) B29C 48/92 (20190201) B29C 48/255 (20190201) B29C 48/298 (20190201) B29C 48/304 (20190201) B29C 48/2888 (20190201) B29C 64/106 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/321 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101426 | Erlebacher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonah D. Erlebacher (Chevy Chase, Maryland); Gina Greenidge (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods of transforming a first carbon material into a second carbon material, and uses thereof. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 18/274840 |
| CURRENT CPC | Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 11/001 (20130101) B22D 11/0611 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Original (OR) Class Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 8/0257 (20130101) C21D 2211/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101601 | Hausner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Sven H. Hausner (Sacramento, California); Julie L. Sutcliffe (Sebastopol, California) |
| ABSTRACT | The present invention provides bi-terminal PEGylated peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates of the present invention further comprise a biological agent such as an imaging agent or a therapeutic agent, e.g., covalently attached to one of the PEG moieties. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating integrin-mediated diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, chronic fibrosis, chronic obstructive pulmonary disease (COPD), lung emphysema, and chronic wounding skin disease. Compositions and kits containing the peptide conjugates of the present invention find utility in a wide range of applications including, e.g., in vivo imaging and immunotherapy. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/945457 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 38/00 (20130101) A61K 47/60 (20170801) A61K 47/64 (20170801) A61K 51/082 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 14/70546 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/32122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101720 | Urgun Demirtas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meltem Urgun Demirtas (Naperville, Illinois); Chaoyi Ba (Schaumburg, Illinois) |
| ABSTRACT | A method of forming a plastic component can includes treating a polysaccharide source with an acid solution under conditions sufficient to extract the starch from the polysaccharide source, wherein the polysaccharide precipitates in the acid solution; separating the precipitate from the acid solution; drying the separated precipitate; admixing the dried precipitate with water to form a slurry; and casting or molding the slurry to form the plastic component. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/372969 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 39/003 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2005/00 (20130101) Polysaccharides; Derivatives Thereof C08B 37/003 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2305/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101756 | Abu-Omar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Mahdi M. Abu-Omar (Goleta, California); Shou Zhao (Goleta, California) |
| ABSTRACT | A thermoset precursor composition includes a backbone comprising an imine bond bonding at least one of: 1) aromatic compounds together, or 2) bonding an aromatic compound to an aliphatic chain, and at least one of: an epoxy group terminating the backbone or an aldehyde group terminating the backbone. The thermoset precursor can have at least two epoxy groups, one epoxy group and one aldehyde group, or two aldehyde groups. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/532212 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/28 (20130101) C08G 59/3227 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/08 (20130101) C08J 2363/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101833 | TEHRANI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sepehr TEHRANI (Toronto, Canada); Quentin VAN OVERMEERE (Mountain View, California); Scott Alan ELROD (Palo Alto, California); Scott E. SOLBERG (San Jose, California); Gabriel IFTIME (Dublin, California); Ravi NEELAKANTAN (Redwood City, California); Bernard D. CASSE (Saratoga, California) |
| ABSTRACT | Disclosed herein in is a radiative cooling formulation including a solvent for providing a viscosity of a radiative cooling material for application onto a surface to be passively cooled. The radiative cooling formulation includes a binder for the radiative cooling material's integrity and bonding to the surface to be passively cooled. The radiative cooling formulation includes a polymer, which, in combination with the binder, provides one or more properties in the radiative cooling material, including a reflectance of or greater than 55% in a wavelengths range of 0.3 to 2.5 microns and a first thermal emissivity peak value greater than 0.85 at a first wavelength in a range of 8 to 13 microns (μm). For example, the polymer is a latex material including a styrene based copolymer. |
| FILED | Tuesday, May 09, 2023 |
| APPL NO | 18/314575 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 2003/3045 (20130101) C08K 2201/005 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/004 (20130101) Original (OR) Class C09D 5/024 (20130101) C09D 7/69 (20180101) C09D 129/14 (20130101) C09D 133/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102057 | RODRIGUEZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alberto RODRIGUEZ (Concord, California); Jamie A. MEADOWS (East Greenwich, Rhode Island); Ning SUN (Fremont, California); Blake A. SIMMONS (San Francisco, California); John M. GLADDEN (Alameda, California) |
| ABSTRACT | The present invention provides for a method for producing a 4-vinylphenol (4VP) and/or 4-vinylguaiacol (4VG), the method comprising: (a) providing a host cell capable of expressing a polypeptide having a phenolic acid decarboxylase (PAD) enzymatic activity wherein the polypeptide is capable of converting p-coumaric (CA) and/or ferulic acid (FA) into 4-vinylphenol (4VP) and/or 4-vinylguaiacol (4VG), respectively; and (b) culturing the host cell in a culture medium to express the polypeptide such that the polypeptide converts CA and/or FA into 4VP and/or 4VG, respectively; wherein the culture medium comprises an organic overlay or phase. |
| FILED | Wednesday, September 13, 2023 |
| APPL NO | 18/466660 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/18 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/22 (20130101) Original (OR) Class Enzymes C12Y 301/01093 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102148 | LAHODA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Edward J. LAHODA (Edgewood, Pennsylvania) |
| ABSTRACT | A covering for reinforcing a base layer of a nuclear fuel cladding is provided. The covering comprises a first layer configured to cover a first portion of the outer surface of the base layer of the nuclear fuel cladding, a second layer surrounding the first layer and the base layer and a third layer surrounding the second layer. The first layer comprises a fiber based material, the second layer comprises an interfacing material and the third layer comprises Chromium. A reinforced cladding for nuclear fuel and a method for producing a reinforced nuclear fuel cladding are also provided. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/934733 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/14 (20130101) Original (OR) Class C23C 14/024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102183 | He et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ting He (Idaho Falls, Idaho); Dong Ding (Idaho Falls, Idaho); Yunya Zhang (Idaho Falls, Idaho); Wei Wu (Idaho Falls, Idaho); Hanping Ding (Idaho Falls, Idaho) |
| ABSTRACT | A method of forming a hydrocarbon product and a protonation product comprises introducing C2H6 to a positive electrode of an electrochemical cell comprising the positive electrode, a negative electrode, and a proton-conducting membrane between the positive electrode and the negative electrode. The proton-conducting membrane comprises an electrolyte material having an ionic conductivity greater than or equal to about 10−2 S/cm at one or more temperatures within a range of from about 150° C. to about 650° C. A potential difference is applied between the positive electrode and the negative electrode of the electrochemical cell to produce the hydrocarbon product and the protonation product. A C2H6 activation system and an electrochemical cell are also described. |
| FILED | Wednesday, April 26, 2023 |
| APPL NO | 18/307294 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 11/04 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) C25B 3/00 (20130101) Original (OR) Class C25B 9/19 (20210101) C25B 11/04 (20130101) C25B 13/04 (20130101) C25B 15/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102372 | Dahi Taleghani |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arash Dahi Taleghani (University Park, Pennsylvania) |
| ABSTRACT | Tuning fracture hydraulic conductivity can be provided so that high hydraulic conductivity in high temperature zones and low hydraulic conductivity in low temperature zones can be defined in enhanced geothermal systems (EGS). Uniform thermal gradient along flow paths can be provided or defined to help provide such conductivity zones. Experimentation performed to evaluate embodiments showed that embodiments could prevent appearance of dominant flow paths between the wells and maintain high heat extraction rates. Embodiments can greatly increase cumulative heat extraction. Embodiments can also be provided for application solely to the injection wells. Other embodiments can position tuning agents between the wells and still help provide control of the fluid flow in the reservoir and enhance heat extraction. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363003 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/80 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/267 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105277 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Neeraj Kumar (Richland, Washington); Mridula V.S. Bontha (Austin, Texas); Andrew D. McNaughton (Richland, Washington); Carter R. Knutson (Salem, Oregon); Jenna A. Pope (Richland, Washington) |
| ABSTRACT | Reinforcement learning is coupled to a deep generative model based on a three-dimensional scaffold model to generate drug candidates targeting a particular protein, building up atom or functional groups from a starting core scaffold. A reward function can use parallel graph neural network models and take the particular protein into account when calculating reward based on criteria such as binding, synthetic accessibility, and the like. In an agent-critic reinforcement learning model, the agent learns to build molecules in three-dimensional space while optimizing the criteria. |
| FILED | Wednesday, September 20, 2023 |
| APPL NO | 18/370814 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/30 (20190201) Original (OR) Class G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105352 | PARIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida); RJ Lee Group, Inc. (Monroeville, Pennsylvania); Concrete Engineering Consultants, Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerry M. PARIS (Gainesville, Florida); Christopher C. FERRARO (Gainesville, Florida); Kyle A. RIDING (Gainesville, Florida); Ashish D. PATEL (Gainesville, Florida); James E. BACIAK (Gainesville, Florida); Eric R. GIANNINI (Gainesville, Florida); W. Calvin MCCALL (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides for cementitious shielding compositions, methods of making the cementitious shielding composition, structures incorporating the concrete cementitious shielding composition, and the like, where the cementitious shielding composition includes elemental boron and/or a boron compound, for example as boron particles. The boron particles can be homogeneously distributed throughout the cementitious shielding composition and can have a largest least dimension of about 100 microns or less. The present disclosure, in some aspects, can reduce or eliminate problems associated with minerals found in concrete aggregates, because those materials are degraded over time by neutron radiation, which leads to disorganized lattice structures, manifested as damage by radiation-induced volumetric expansion (RIVE), and potentially further damage from alkali-silica reaction (ASR). |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 18/275147 |
| CURRENT CPC | Nuclear Reactors G21C 11/028 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 1/042 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105418 | BLOOM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Integrated Dynamic Electron Solutions, Inc. (Pleasanton, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruth BLOOM (Pleasanton, California); Sang Tae PARK (Pleasanton, California); Bryan REED (Pleasanton, California); Daniel MASIEL (Pleasanton, California) |
| ABSTRACT | Methods and systems for acquiring transmission electron microscope video data on a rolling-shutter detector at an enhanced frame rate and without temporal distortions are described. Also described are methods to enhance the dynamic range of image and diffraction data acquired using a transmission electron microscope. The disclosed methods and systems may also be applicable to photon detection and imaging systems. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/367066 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/26 (20130101) Original (OR) Class H01J 37/244 (20130101) H01J 37/1474 (20130101) H01J 2237/2802 (20130101) H01J 2237/2804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105875 | Chowdhury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Asif Jahangir Chowdhury (Portland, Oregon); Mona Mostafa Hella (Watervliet, New York) |
| ABSTRACT | A photodiode structure including a silicon substrate, an oxide layer on the silicon substrate, a silicon on insulator region on the oxide layer, a germanium absorption region, a silicon nitride waveguide, a cathode region, and an anode region is provided. The germanium absorption region is at least partially disposed in a recess of the silicon on insulator region. The germanium absorption region includes a top surface having a first width and a bottom surface having a second width, the first width being greater than the second width. The cathode region is formed at a first side of the germanium absorption region, and the anode region is formed at a second side of the germanium absorption region that is opposite the first side. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 18/275628 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/102 (20130101) G02B 2006/12176 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1075 (20130101) Original (OR) Class H01L 31/1808 (20130101) H01L 31/02327 (20130101) H01L 31/03529 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105908 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Zonghai Chen (Bollingbrook, Illinois); Yingying Xie (Woodridge, Illinois) |
| ABSTRACT | A process for modifying a surface chemistry of a cathode active material includes providing a powder of the cathode active material, wetting the powder of cathode active material with an efficient amount of a solution to form a mixture, and baking the mixture to obtain a surface modified cathode active material, wherein: the cathode active material has a formula of LiNixMnyCo1-x-yO2, wherein 0≤x≤1, 0≤y≤1, and 0≤x+y≤1; the solution comprises a solvate and a solvent; and the solvate comprises H3BO3, H3PO4, a phosphate salt, a hydrogenphosphate salt, a dihydrogenphosphate salt, or a combination of any two or more thereof. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/952583 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0471 (20130101) Original (OR) Class H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105916 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Guiliang Xu (Naperville, Illinois); Yuzi Liu (Naperville, Illinois); Chen Zhao (Woodridge, Illinois); Khalil Amine (Oakbrook, Illinois) |
| ABSTRACT | The present invention provides, in part, electrodes (e.g., cathodes) comprising electroactive materials (e.g., cathode active materials), a primary coating comprising a high entropy metal oxide (HEO), and optionally a secondary coating layer comprising an ionic and electronic conductive polymer, as well as an energy storage device thereof, and methods for making the same. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/955092 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 7/54 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/621 (20130101) H01M 4/625 (20130101) H01M 4/1391 (20130101) H01M 10/0569 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105998 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Guiliang Xu (Naperville, Illinois); Chen Zhao (Woodridge, Illinois); Khalil Amine (Oakbrook, Illinois) |
| ABSTRACT | The present invention provides, in part, an electrochemical energy storage device comprising a metal anode, a separator, a high-mass-loading selenium-sulfur cathode and a lean electrolyte. In particular, the electrolyte described herein employs active solid-electrolyte interphase engineering salts and features unique solvating structure. The combination of high-mass-loading S cathode and the particular electrolytes can enhance one or more of the following cell properties: energy density, cycling stability, safety, and working temperature window. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/954839 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/136 (20130101) H01M 4/0435 (20130101) H01M 4/0471 (20130101) H01M 4/625 (20130101) H01M 10/052 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2300/0042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240106072 | YERSAK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Thomas A. YERSAK (Royal Oak, Michigan); Ion C. HALALAY (Grosse Pointe Park, Michigan); Yubin ZHANG (Madison Heights, Michigan) |
| ABSTRACT | A bicontinuous separating layer include a separating matrix having pores and a solid-state electrolyte disposed in the pores of the separating matrix. In certain variations, the bicontinuous separating layer is prepared by contacting a solid-state electrolyte liquid-state precursor with the separating matrix and heating the infiltrated separating matrix to a temperature between about 25° C. and about 300° C. The solid-state electrolyte liquid-state precursor includes a solvent and a solid-state electrolyte powder or a solid-state electrolyte precursor. In other variations, the bicontinuous separating layer may be prepared by contacting a solid-state electrolyte powder with a separating matrix to form a physical mixture and heating the physical mixture to a temperature between about 240° C. and about 500° C., where the separating matrix is defined by a polymer having a melting temperature greater than about 215° C., and the solid-state electrolyte has a melting temperature greater than about 300° C. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/955151 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 50/406 (20210101) H01M 50/417 (20210101) H01M 50/423 (20210101) H01M 50/437 (20210101) H01M 50/446 (20210101) Original (OR) Class H01M 50/491 (20210101) H01M 50/497 (20210101) H01M 2300/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240106678 | Bukowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen A. Bukowski (Idaho Falls, Idaho); Jake P. Gentle (Idaho Falls, Idaho) |
| ABSTRACT | One or more embodiments of the present disclosure may include a device including a first port configured to be communicatively coupled to a first device, a second port configured to be communicatively coupled to a second device, and logic. The logic may be configured, in a permissive operational state, to receive a signal from the first device and transmit the signal to the second device. The logic may further be configured, in a constrained operational state, to transmit a hold signal to the first device, wherein the hold signal instructs the first device to not transmit signals. Associated methods are also disclosed. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 18/251695 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 12/413 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240107653 | Gribb et al. |
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| FUNDED BY |
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| APPLICANT(S) | SHINE Technologies, LLC (Janesville, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tye Gribb (Fitchburg, Wisconsin); Preston Barrows (Madison, Wisconsin) |
| ABSTRACT | A beam accelerator system operable to produce a medical isotope, including an ion accelerator that generates an ion beam; a low-pressure chamber; an anode adjacent and fluidly connected to the low-pressure chamber; a plasma window adjacent and fluidly connected to the anode; and a cathode housing adjacent and fluidly connected to the plasma window. The plasma window has a plurality of plates, each plate having an aperture that is aligned with an aperture in one or more adjacent plates to form a plasma channel. One or more plates in the plurality of plates includes a unitary plate having an aperture therein, and one or more cooling channels entering the unitary plate at a first side of the unitary plate and exiting the unitary plate at a second side of the unitary plate. The one or more cooling channels run through a thickness of the unitary plate. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/951975 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 6/00 (20130101) Original (OR) Class H05H 2006/002 (20130101) H05H 2242/10 (20130101) H05H 2277/116 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240101617 | Boothby et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Christopher Clark Boothby (Chapel Hill, North Carolina); Robert Patrick Goldstein (Carrboro, North Carolina); Gary Joseph Pielak (Chapel Hill, North Carolina); Samantha Piszkiewicz (Chapel Hill, North Carolina); Alexandra Harrison Brozena (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention relates to methods and compositions for stabilizing proteins. The invention provides compositions comprising at least one tardigrade disordered protein (TDP) and at least one heterologous polypeptide and/or peptide of interest. Further provided are methods for stabilizing proteins and for producing organisms and cells having increased tolerance to desiccation and/or drought. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/513744 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 1/008 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/18 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 47/42 (20130101) Peptides C07K 14/43504 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/74 (20130101) C12N 15/81 (20130101) C12N 15/8273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102167 | Dickie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Matthew R. Dickie (Altadena, California); Su C. Chi (Pasadena, California); Billy Chun-Yip Li (Pasadena, California); William C. West (South Pasadena, California); Harold Frank Greer (Los Angeles, California) |
| ABSTRACT | A boat used in a chemical vapor deposition (CVD) furnace is configured to hold one or more complex three-dimensional (3D) structures when performing a coating. A platform wafer is placed horizontally in the boat to support the complex 3D structures and a mount is positioned to secure the complex 3D structures on the platform wafer during the CVD process. One or more “witness” wafers may also be placed in the boat for analyzing the thin-film coating. The platform wafer may be positioned between or bracketed by the vertical wafers. Parts with coatings manufactured using LPCVD are further disclosed. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/476808 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/345 (20130101) C23C 16/4583 (20130101) C23C 16/4587 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102657 | Kapat et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jayanta Kapat (Oviedo, Florida); Richard Blair (Oviedo, Florida); Marcel Otto (Orlando, Florida); Erik Fernandez (Oviedo, Florida) |
| ABSTRACT | A power system for an engine that can be used in an aircraft, a marine vessel or a land vehicle has a storage tank containing ammonia. An engine supported on the vehicle is configured to operate using hydrogen gas as fuel. A cracking device in or adjacent the engine receives heat from operation of the engine, e.g., from a compressor or a combustion chamber, and also receives ammonia from the storage tank, and it uses the heat from the engine to dissociate the ammonia to produce hydrogen gas. The cracking device supplies the hydrogen gas to the engine, which has a combustor in which combustion of the hydrogen gas takes place. The energy from the combustion drives the engine so as to provide mechanical energy. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/372646 |
| CURRENT CPC | Marine Propulsion or Steering B63H 21/16 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/12 (20130101) B64D 37/04 (20130101) B64D 37/34 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103184 | SCHOLZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The MITRE Corporation (Mclean, Virginia); NASA Langley Research Center (Hampton, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (Mclean, Virginia); NASA Langley Research Center (Hampton, Virginia) |
| INVENTOR(S) | Arthur K. SCHOLZ (Mclean, Virginia); Emily V. Bates (Mclean, Virginia); Kenneth William Schmitt (Wobum, Massachusetts); Evan Tyler Dill (Poquoson, Virginia); Julian Gutierrez (Boston, Massachusetts) |
| ABSTRACT | A method for global navigation satellite system (GNSS)-based navigation may include retrieving terrain data for a geographical region and satellite orbit data for a GNSS comprising a plurality of satellites. Then, for of a plurality of time steps in a time period and for each of a plurality of lateral positions in the geographic region, a minimum height at which each satellite is visible from the lateral position at the time step may be determined. Unique combinations of satellites visible from the lateral position at the time step may be identified and error objects indicating GNSS performance quality corresponding to the unique combination of satellites may be generated. Performance quality information may be produced based on the one or more unique combinations of satellites and the respective one or more error objects. At least one aircraft may be operated based on this performance quality information. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468483 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/05 (20130101) G01S 19/396 (20190801) Original (OR) Class Traffic Control Systems G08G 5/0034 (20130101) G08G 5/0069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103510 | Timmaraju et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); CHEVRON U.S.A. Inc. (San Ramon, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Virisha Timmaraju (Pasadena, California); Eric Junkins (Westminster, Colorado); Valentinos Constantinou (Pasadena, California); Asitang Mishra (Frisco, Texas); Sakthivel Kandasamy (Houston, Texas) |
| ABSTRACT | Relationships between alarms are modeled using a graph to identify root cause of a sequence of alarms (an alarm flood). The nodes of the graph represent different alarms, and the edges between the nodes are scored using pairwise analysis of when the alarms occurred. The graph is divided into multiple subgraphs representing alarm clusters. Root cause analysis of the sequence of alarms is performed by generating and simplifying directed graphs for events within the alarm clusters. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 18/271986 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 23/027 (20130101) Original (OR) Class G05B 23/0275 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240101489 | Malakar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arindam Malakar (Lincoln, Nebraska); Daniel Snow (Lincoln, Nebraska); Chittaranjan Ray (Lincoln, Nebraska) |
| ABSTRACT | The present disclosure describes compositions that include ferrihydrite (Fh) and methods of using such compositions to improve the growth of plants. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/368904 |
| CURRENT CPC | Planting; Sowing; Fertilising A01C 1/06 (20130101) Inorganic Fertilisers Not Covered by Subclasses C05B, C05C; Fertilisers Producing Carbon Dioxide C05D 9/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101854 | Catchmark et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey M. Catchmark (State College, Pennsylvania); Adam Ross Plucinski (State College, Pennsylvania) |
| ABSTRACT | This document provides polymer compositions (e.g., biopolymer compositions) and coatings. For example, methods and materials related to polymer compositions (e.g., biopolymer compositions) and coatings as well as methods and materials for making and using such compositions (e.g., biopolymer compositions) and coatings are provided. |
| FILED | Wednesday, September 06, 2023 |
| APPL NO | 18/242946 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/26 (20130101) Compositions of Macromolecular Compounds C08L 1/02 (20130101) C08L 89/005 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 101/286 (20130101) Original (OR) Class C09D 105/00 (20130101) C09D 105/08 (20130101) Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for D21H 11/18 (20130101) D21H 17/22 (20130101) D21H 17/25 (20130101) D21H 17/68 (20130101) D21H 19/40 (20130101) D21H 19/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240102027 | Van Oosterwijk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | US BIOLOGIC, INC (Memphis, Tennessee); The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | US BIOLOGIC, INC (Memphis, Tennessee); The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Jolieke G. Van Oosterwijk (Memphis, Tennessee); Luciana Meirelles Richer (Memphis, Tennessee); Douglas Steven Zetechka, JR. (Cordova, Tennessee); Hyun Soon Lillehoj (West Friendship, Maryland); Woohyun Kim (Ellicott City, Maryland); Cyril Gay (Bethesda, Maryland); Christopher Anthony Przybyszewski (Southaven, Tennessee) |
| ABSTRACT | The inventive subject matter includes an antimicrobial peptide vectored composition made of a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules. More specifically these novel recombinant antimicrobial peptide effector molecules exhibit preferential antimicrobial activity. In some embodiments, the antimicrobial activity is facilitated via interaction with the lipid bilayer of the parasitic cell form, leading to membrane pore formation and resulting in cell lysis. The utility of the current inventive subject matter has demonstrated a reduced viability of Eimeira acervulina sporozoites was shown in vitro using a sporozoite killing assay. More specifically, the antimicrobial peptide vectored composition is a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules, wherein the one or more recombinant antimicrobial peptide effector molecules are engineered from a NK-lysin gene and the one or more recombinant antimicrobial peptide effector molecules are engineered to express functionally active NK-2. More specifically, the one or more recombinant antimicrobial peptide effector molecules induce cytotoxicity against infectious agents of the phylum of Apicomplexa. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/376543 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/742 (20130101) Peptides C07K 14/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/75 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240100026 | MARKOWITZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); The United States Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford MARKOWITZ (Pepper Pike, Ohio); Joseph READY (Carrollton, Texas); Andrew PIEPER (Shaker Heights, Ohio) |
| ABSTRACT | A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor. |
| FILED | Thursday, May 11, 2023 |
| APPL NO | 18/196106 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/4365 (20130101) Original (OR) Class A61K 31/4375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240100047 | Mohapatra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Subhra Mohapatra (Lutz, Florida); Shyam S. Mohapatra (Lutz, Florida); Karthick Mayilsamy (Tampa, Florida); Eleni Markoutsa (Tampa, Florida); Andrew McGill (Tampa, Florida) |
| ABSTRACT | A nanosystem and methods of treating, including prophylactically, coronavirus infections, such as those caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), by administering such nanosystem to a patient is presented. The nanosystem may be comprised of a single or a combination of therapeutic agents, optionally encapsulated in a nanoparticle having a targeting moiety directed to the particular coronavirus. For CoV-2 infections, at least one therapeutic agent, such as the dual DPP4/ACE2 inhibitor sitagliptin, may optionally be encapsulated within a nanoparticle having a fatty acid such as linoleic acid, as the targeting moiety. Administration can occur intranasally prior to infection for prophylactic treatment or post-infection for treatment of the viral infection. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/389272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 9/5123 (20130101) A61K 31/155 (20130101) A61K 31/4985 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240101658 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia); The US Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | Augusta University Research Institute, Inc. (Augusta, Georgia); The US Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Kebin Liu (Augusta, Georgia); John Klement (Augusta, Georgia); Priscilla S. Redd (Augusta, Georgia) |
| ABSTRACT | Antibodies and antigen binding fragments thereof that immunospecifically bind OPN (OPN) and inhibit OPN activity are provided herein. The disclosed antibodies and antigen binding fragments are useful for modulating signal transduction through OPN proteins. The antibodies and antigen-binding fragments are useful for the treatment or prevention of cancer, osteoporosis, or other immune diseases. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/460277 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240102895 | HESKETT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aerosol Devices Inc. (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominick Dalton Reyes HESKETT (Greeley, Colorado); Patricia Bea KEADY (Fort Collins, Colorado) |
| ABSTRACT | The present invention features a device and method for directly collecting airborne particles onto a swab collection substrate. Prior to collection, water vapor may be condensed onto the particles to increase their average diameter. The particles are expelled from one or more acceleration nozzles for gentle impaction onto the swab collection substrate and may be further analyzed through chemical or biological assays. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/275713 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2208 (20130101) G01N 1/2214 (20130101) Original (OR) Class G01N 2001/2282 (20130101) G01N 2001/2285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240105418 | BLOOM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Integrated Dynamic Electron Solutions, Inc. (Pleasanton, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruth BLOOM (Pleasanton, California); Sang Tae PARK (Pleasanton, California); Bryan REED (Pleasanton, California); Daniel MASIEL (Pleasanton, California) |
| ABSTRACT | Methods and systems for acquiring transmission electron microscope video data on a rolling-shutter detector at an enhanced frame rate and without temporal distortions are described. Also described are methods to enhance the dynamic range of image and diffraction data acquired using a transmission electron microscope. The disclosed methods and systems may also be applicable to photon detection and imaging systems. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/367066 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/26 (20130101) Original (OR) Class H01J 37/244 (20130101) H01J 37/1474 (20130101) H01J 2237/2802 (20130101) H01J 2237/2804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20240101109 | ROESLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffery R. ROESLER (Champaign, Illinois); Sachindra DAHAL (San Francisco, California) |
| ABSTRACT | A method of maintaining lateral lane position of a vehicle traveling on a roadway includes detecting a magnetic field from a surface of the roadway, where the surface includes a magnetic or magnetized material, and adjusting a lateral position of the vehicle on the roadway such that the magnetic field has a maximum signal at a predetermined location on the vehicle, e.g., at or near a centerline of the vehicle. The magnetic or magnetized material may be localized to a longitudinal segment of the surface approximately centered between lane lines or at another desired location. Detection of the magnetic field may take place continuously while the vehicle is moving. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/368866 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/12 (20130101) Original (OR) Class B60W 2420/50 (20130101) B60W 2552/53 (20200201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20240101632 | BHATNAGAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Parijat BHATNAGAR (Menlo Park, California); Sherri NEWMYER (Menlo Park, California) |
| ABSTRACT | An example genetically engineered electrically-stimulated (ES) cell comprises an exogenous polynucleotide sequence that includes an electrical-sensor element, an actuator element, and an effector element. The electrical-sensor element encodes a voltage-gated calcium ion channel (CaV), wherein the CaV is configured to transition from a closed state to an open state in response to stimulation. The actuator element encodes a transcription factor binding site that upregulates synthesis of an effector protein. The effector element encodes the effector protein, wherein, in response to the transition of the CaV to the open state, the genetically engineered ES effector cell is configured to activate and, to synthesize and secrete the effector protein. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 18/274255 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 41/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/555 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20240106683 | Crompton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | A10 Systems Inc (Lowell, Massachusetts) |
| ASSIGNEE(S) | A10 Systems Inc (Lowell, Massachusetts) |
| INVENTOR(S) | Bryan Crompton (Lowell, Massachusetts); Tanay Mehta (Plano, Texas); Daniel Giger (Lowell, Massachusetts); Apurva N. Mody (Chelmsford, Massachusetts) |
| ABSTRACT | One or more aspects of the present disclosure are directed methods, devices and computer-readable media for receiving, at a receiver, a signal, the signal including a cover signal and an embedded co-channel anomalous signal; performing, at the receiver, signal processing on the signal to determine one or more characteristics of the signal; inputting, at the receiver, the one or more characteristics into one or more trained neural networks; and receiving, as an output of the trained neural network, a classification of the signal, the classification identifying the cover signal and the embedded co-channel anomalous signal. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/369586 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0254 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240104917 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | This application relates to a method and a system for compressing a captured image of an item such as a mailpiece or parcel. The system may include a memory configured to store images of a plurality of items captured while the items are being transported and a processor in data communication with the memory. The processor may be configured to receive or retrieve one or more of the captured images, perform a wavelet scattering transform on the one or more captured images, perform deep learning on the wavelet scattering transformed images to classify the wavelet scattering transformed images and compress the classified wavelet scattering transformed images. Various embodiments can significantly improve a compression efficiency, a communication efficiency of compressed data and save a memory space so that the functionality of computing devices is significantly improved. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/534459 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/084 (20130101) Image Data Processing or Generation, in General G06T 9/002 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) Original (OR) Class G06V 30/413 (20220101) G06V 30/19173 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240099901 | Boston et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as represented by the Secretary of the Department of Health Agency (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Boston (Silver Spring, Maryland); Mostafa Ahmed (Silver Spring, Maryland) |
| ABSTRACT | A surgical tampon for being disposed into and removed from an anatomical cavity of a mammalian patient by a doctor. the surgical tampon comprises absorbent material for absorbing and retaining bodily fluids from a patient. The tampon has at least one functional additive to assist the doctor during surgery, particularly nasopharyngeal surgery. The functional additive comprises at least one of luminescent material, a pulse oximeter, soluble adhesive and combinations thereof as selected by the doctor for a particular surgical procedure. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936004 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/34 (20130101) A61F 13/2002 (20130101) Original (OR) Class A61F 13/2074 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/42 (20130101) A61L 15/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240103182 | Acheson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | John E. Acheson (Anamosa, Iowa); Michael N. Kloos (Atkins, Iowa); Nathaniel L. James (Marion, Iowa); Mitchell Dennis (Cedar Rapids, Iowa) |
| ABSTRACT | Techniques are provided for employing an embedded software defined radio (SDR) in a navigation system. A navigation system implementing the techniques according to an embodiment includes a global positioning system (GPS) receiver configured to acquire and track received GPS signals. The system also includes an SDR configured to process received communication signals. The communication signals include timing data. The SDR is further configured to calculate position and navigation data based on a combination of the processed communication signals and the tracked GPS signals provided by the GPS receiver. The system further includes a system timer configured to provide a common time base for use by the GPS receiver and the SDR. The navigation system is implemented in an application specific integrated circuit (ASIC). |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953512 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/37 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, March 28, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240328.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page