FedInvent™ Patent Applications
Application Details for Thursday, April 11, 2024
This page was updated on Tuesday, June 18, 2024 at 02:18 PM GMT
Department of Health and Human Services (HHS)
| US 20240114903 | Bloomquist et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey R. Bloomquist (Gainesville, Florida); Edmund J. Norris (Gainesville, Florida) |
| ABSTRACT | The subject matter described herein is directed to synergistic compositions comprising pyrethrum vapor and a second agent selected from the group consisting of an essential oil and a compound of Formula I. In other embodiments, topical synergistic compositions comprising pyrethrum and an essential oil are described. Additionally described are methods for repelling and controlling arthropods using the synergistic compositions. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 18/271769 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) A01N 37/08 (20130101) Original (OR) Class A01N 65/06 (20130101) A01N 65/08 (20130101) A01N 65/10 (20130101) A01N 65/28 (20130101) A01N 65/36 (20130101) A01N 65/44 (20130101) A01N 65/48 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 7/04 (20210801) A01P 17/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115130 | KLIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ami KLIN (Atlanta, Georgia); Warren JONES (Decatur, Georgia) |
| ABSTRACT | Systems, devices, and methods are described for assessing the risk of developmental, cognitive, social, or mental abilities or disabilities in very young patients (e.g., in the first 2-6 months of life). Generally, the decline in visual fixation of a subject over time with respect to certain dynamic stimuli provides a marker of possible abilities or disabilities (such as ASD). The visual fixation of the subject is identified, monitored, and tracked over time through repeated eye tracking sessions, and data relating to the visual fixation is then analyzed to determine a possible increased risk certain conditions in the subject. A change in visual fixation as compared to similar visual fixation data of typically-developing subjects or to a subject's own, prior visual fixation data provides an indication of a developmental, cognitive, or mental ability or disability. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545362 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/113 (20130101) Original (OR) Class A61B 5/163 (20170801) A61B 5/167 (20130101) A61B 5/168 (20130101) A61B 2503/04 (20130101) A61B 2503/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115221 | Tonge et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for the State University of New York (Albany, New York) |
| INVENTOR(S) | Peter Tonge (Setauket, New York); Zhuo ZHANG (Coram, New York); Peter Smith-Jones (Port Jefferson, New York); Li LIU (Stony Brook, New York); Hui WANG (Woodside, New York) |
| ABSTRACT | The present invention provides a composition comprising the compound having the structure: or a salt of the compound; 4-amino-2-[19F]-fluorobenzoic acid or a salt of 4-amino-2-[19F]-fluorobenzoic acid; and at least one acceptable carrier. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511588 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/037 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 51/0402 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/001 (20130101) Acyclic or Carbocyclic Compounds C07C 227/12 (20130101) C07C 229/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115261 | Khristov et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Vladimir R. Khristov (Washington, District of Columbia); Steven T. Charles (Memphis, Tennessee); Juan A. Amaral (Silver Spring, Maryland); Arvydas Maminishkis (Washington, District of Columbia); Kapil Bharti (Bethesda, Maryland) |
| ABSTRACT | A surgical clamp for aligning the margins of incised or wounded tissue has jaws with parallel clamping faces, and a handle for manipulating the clamp to align the margins of the tissue. The jaws are in a normally closed position, however they can be opened by compressing the handle to open the jaws. Prongs project from the inferior surface of the jaws. The clamp is positioned in a desired position over the margins of a wound to be closed, the prongs engage the margins of the wound to be aligned, and the jaws are closed by releasing compressive force on the handle. As the jaws close the prongs help move the tissue into alignment. Suture guide slots through the jaws assist in the placement of precisely placed sutures across the incision. The disclosed surgical clamp is particularly suited for selectively closing and reopening surgical incisions, such as a sclerotomy incision in the eye. Methods are disclosed for using the clamp during intraocular and other surgical or minimally invasive procedures. In one example the clamp is used during implantation into the retina of a scaffold on which choroid and retinal pigment epithelium cells and retina grow in a three-dimensional matrix that mimics the native structure of the retina. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/226043 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/083 (20130101) Original (OR) Class A61B 17/0482 (20130101) A61B 2017/081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115264 | Jain |
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| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri) |
| ASSIGNEE(S) | Saint Louis University (St. Louis, Missouri) |
| INVENTOR(S) | Ajay Kumar Jain (St. Louis, Missouri) |
| ABSTRACT | A recirculation system for recirculating intestinal content within an intestinal tract of a subject including a recirculation pathway extending from a distal portion of the intestinal tract to a proximal portion of the intestinal tract forming a recirculation loop for recirculating the intestinal content through the proximal portion of the intestinal tract to increase nutrient absorption from the intestinal content. A bypass pathway in fluid communication with the recirculation pathway and configured to divert the intestinal content from the recirculation pathway to continue along the intestinal tract. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/480631 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1114 (20130101) Original (OR) Class A61B 2017/1135 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2496 (20130101) A61F 2002/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115508 | Popov et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
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| INVENTOR(S) | Alexey Popov (Waltham, Massachusetts); Elizabeth M. Enlow (Waltham, Massachusetts); James Bourassa (Somerville, Massachusetts); Colin R. Gardner (Concord, Massachusetts); Hongming Chen (Belmont, Massachusetts); Laura M. Ensign (Towson, Maryland); Samuel K. Lai (Carrboro, North Carolina); Tao Yu (Baltimore, Maryland); Justin Hanes (Baltimore, Maryland); Ming Yang (Towson, Maryland) |
| ABSTRACT | Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529962 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/5031 (20130101) Original (OR) Class A61K 9/5089 (20130101) A61K 9/5138 (20130101) A61K 31/12 (20130101) A61K 31/56 (20130101) A61K 31/58 (20130101) A61K 31/341 (20130101) A61K 31/405 (20130101) A61K 31/409 (20130101) A61K 31/496 (20130101) A61K 31/522 (20130101) A61K 31/569 (20130101) A61K 31/573 (20130101) A61K 31/635 (20130101) A61K 31/662 (20130101) A61K 31/675 (20130101) A61K 47/34 (20130101) A61K 49/0089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115514 | Rodell et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Rodell (Jamaica Plain, Massachusetts); Ralph Weissleder (Peabody, Massachusetts) |
| ABSTRACT | Disclosed herein are nanoparticles that include one or more cyclodextrin moieties crosslinked by a linker. The cyclodextrin moieties can complex therapeutic (e.g., anticancer) agents, and can be used to treat diseases such as cancer. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/215309 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5161 (20130101) Original (OR) Class A61K 31/4745 (20130101) A61K 45/06 (20130101) A61K 47/54 (20170801) A61K 47/65 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115518 | Harrelson et al. |
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| FUNDED BY |
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| APPLICANT(S) | PACIFIC UNIVERSITY (Forest Grove, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Harrelson (Forest Grove, Oregon); Deepa A. Rao (Beaverton, Oregon) |
| ABSTRACT | Compounds, compositions, and methods of use of such compounds and compositions are provided for reducing human dependency to nicotine. In one example, a method of treating an individual with an addiction to nicotine comprises administering to the individual a compound that is a structural analog of trans-cinnamaldehyde. Based on the administration, a rate at which nicotine is metabolized may be reduced, which in turn may reduce a desire for the individual to consume nicotine-containing products. |
| FILED | Monday, November 27, 2023 |
| APPL NO | 18/520444 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/11 (20130101) Original (OR) Class A61K 31/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/34 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115521 | ABATE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); Research Foundation of the City University of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Getahun ABATE (St. Louis, Missouri); John TAVIS (Kirkwood, Missouri); David W. GRIGGS (Ballwin, Missouri); Ryan MURELLI (Belleville, New Jersey) |
| ABSTRACT | The present disclosure provides compounds, methods, and compositions which may be used to treat tuberculosis. In some embodiments, these compounds and compositions have a bactericidal property against Mycobacterium tuberculosis (Mtb). Methods of employing such agents are also provided. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470317 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/122 (20130101) Original (OR) Class A61K 31/136 (20130101) A61K 31/235 (20130101) A61K 31/353 (20130101) A61K 31/402 (20130101) A61K 31/426 (20130101) A61K 31/495 (20130101) A61K 31/496 (20130101) A61K 31/5375 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115527 | Hoffman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| INVENTOR(S) | Ronald Hoffman (New York, New York); Min Lu (New York, New York) |
| ABSTRACT | Provided herein are compositions comprising CXCR1/CXCR2 inhibitors as well as methods of using the CXCR1/CXCR2 inhibitors disclosed herein. In embodiments, provided are methods of treating myelofibrosis, methods of decreasing bone marrow fibrosis, methods of reducing the interaction of IL-8 to CXCR1 and/or CXCR2, and methods of reducing the activity or and/or signaling through CXCR1 and/or CXCR by administering to a subject in need thereof an effective amount of a CXCR1/CXCR2 inhibitor disclosed herein. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 18/251670 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115533 | RATAN et al. |
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| APPLICANT(S) | Neuronasal, Inc. (Wexford, Pennsylvania); Burke Neurological Institute (White Plains, New York) |
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| INVENTOR(S) | Rajiv R. RATAN (Scarsdale, New York); Saravanan KARUPPAGOUNDER (White Plains, New York); Thomas BRADSHAW (Wynnewood, Pennsylvania) |
| ABSTRACT | The present disclosure describes methods of treating a central nervous system condition caused by a traumatic brain injury using a 5-lipoxigenase activating protein (FLAP) inhibitor, for example, N-acetylcysteine or nordihydroguaiaretic acid. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/509935 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 31/05 (20130101) A61K 31/145 (20130101) A61K 31/198 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/18 (20180101) A61P 25/24 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115538 | Nagaraj et al. |
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| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
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| INVENTOR(S) | Ram H. Nagaraj (Aurora, Colorado); Rooban B. Nahomi (Aurora, Colorado); Sandip Nandi (Goa, India) |
| ABSTRACT | Methods of treating, preventing, delaying, or reversing presbyopia in a subject involve administering a pharmaceutically effective amount of an aggrelyte to the subject. The aggrelyte may be one or more of N,S-diacetyl-L-cysteine methyl ester, S-acetyl-N-(3,3,-dimethylbutanoyl)-L-cysteinate, or N-acetyl cysteine methyl ester. The aggrelyte may be administered topically. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/193910 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/223 (20130101) Original (OR) Class A61K 31/265 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115552 | Riggins et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Riggins (White Hall, Maryland); Renyuan Bai (Joppa, Maryland); Verena Staedtke (Baltimore, Maryland); Avadhut D. Joshi (Baltimore, Maryland); Tara Williamson (Baltimore, Maryland) |
| ABSTRACT | Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy. Three polymorphs of mebendazole exist, but the relative polymorph content for existing drugs varies, and the therapeutic anti-cancer relevance of the different polymorphs was unknown. As an oral drug mebendazole polymorph C is a superior form, and it reaches the brain and brain tumors in effective concentrations. Efficacy is further improved by combining mebendazole with a P-glycoprotein inhibitor. Mebendazole may also be used for therapy of other cancers, as well as a chemo-preventative agent. |
| FILED | Thursday, November 30, 2023 |
| APPL NO | 18/525209 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/10 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 9/50 (20130101) A61K 9/0056 (20130101) A61K 9/1605 (20130101) A61K 31/192 (20130101) A61K 31/473 (20130101) A61K 31/4184 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115563 | Laberge et al. |
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| APPLICANT(S) | Buck Institute for Research on Aging (Novato, California); Mayo Foundation for Medical Education and Research (Rochester, Minnesota); Unity Biotechnology, Inc. (South San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Remi-Martin Laberge (South San Francisco, California); Judith Campisi (Berkeley, California); Marco Demaria (San Francisco, California); Bennett G. Childs (Rochester, Minnesota); Jan M. A. Van Deursen (Rochester, Minnesota); Nathaniel David (South San Francisco, California); Alain Philippe Vasserot (South San Francisco, California) |
| ABSTRACT | This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease. |
| FILED | Monday, August 07, 2023 |
| APPL NO | 18/215731 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 9/0073 (20130101) A61K 31/404 (20130101) A61K 31/428 (20130101) A61K 31/495 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/728 (20130101) A61K 31/4178 (20130101) A61K 31/4375 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) A61K 47/36 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 11/00 (20180101) A61P 25/16 (20180101) A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0081 (20130101) C12N 2503/02 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115566 | JACKOWSKI et al. |
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| APPLICANT(S) | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suzanne JACKOWSKI (Bartlett, Tennessee); Charles O. ROCK (Bartlett, Tennessee); Matthew W. FRANK (Memphis, Tennessee) |
| ABSTRACT | The present disclosure relates to methods of identifying subjects in need of treatment for, e.g., a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. The methods may comprise assessing levels of carnitines, CoA, and/or various metabolites and biomarkers and administration of therapeutics useful in the treatment of CASTOR disorders, metabolic diseases, and/or neurological diseases. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present inventions. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 18/257680 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/501 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 25/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115569 | Noble et al. |
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| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Paul W. Noble (Beverly Hills, California); Dianhua Jiang (Encino, California) |
| ABSTRACT | The invention of the present disclosure relates to methods for diagnosing and for treating a progressive lung disease in a subject. In various embodiments, the method for treating a progressive lung disease in a subject includes administering a pharmaceutical composition comprising a Human Epidermal Growth Factor Receptor 2 (HER2) blocking agent and a pharmaceutically acceptable carrier to the subject, wherein the method improves clinical outcome compared to an untreated control. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/276115 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 47/6803 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115574 | Haughey et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Norman Haughey (Baltimore, Maryland); Barbara Slusher (Kingsville, Maryland); Camilo Rojas (Baltimore, Maryland) |
| ABSTRACT | Methods for treating a Human Immunodeficiency Virus (HIV) infection comprising administering to a subject in need of treatment thereof an effective amount of a small molecule nSMase2 inhibitor. |
| FILED | Tuesday, August 08, 2023 |
| APPL NO | 18/446244 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 31/5025 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115583 | Blau et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Helen M. Blau (Stanford, California); Adelaida R. Palla (Stanford, California); Andrew Tri Van Ho (Paris, France) |
| ABSTRACT | Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration and methods of increasing muscle mass are also provided herein. |
| FILED | Monday, May 15, 2023 |
| APPL NO | 18/317752 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/46 (20130101) A61K 31/47 (20130101) A61K 31/167 (20130101) A61K 31/245 (20130101) A61K 31/445 (20130101) A61K 31/5575 (20130101) Original (OR) Class A61K 33/00 (20130101) A61K 33/06 (20130101) A61K 33/24 (20130101) A61K 33/32 (20130101) A61K 35/64 (20130101) A61K 35/583 (20130101) A61K 38/465 (20130101) A61K 38/1703 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) A61P 21/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115596 | Pyle et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anna Marie Pyle (Guilford, Connecticut); Akiko Iwasaki (Guilford, Connecticut); Tianyang Mao (New Haven, Connecticut) |
| ABSTRACT | The present disclosure provides small hairpin nucleic acid molecules capable of stimulating interferon production. The nucleic acid molecules of the present disclosure has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises at least one 5′-triphosphate and/or at least one 5′-diphosphate. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection, and/or ameliorating, minimizing, reversing, and/or preventing persistent SARS-CoV-2 viral infection, and/or minimizing or preventing SARS-CoV-2 viral infection-derived mortality and/or lethality, in a subject. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection in a tumor-bearing subject. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection in an immune-compromised and/or immunodeficient subject. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488250 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115608 | LIM et al. |
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| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendell A. LIM (San Francisco, California); Kyle DANIELS (San Francisco, California) |
| ABSTRACT | An engineered immune receptor (e.g., a chimeric antigen receptor (CAR) or chimeric costimulatory receptor (CCR)) that contains one or more short linear motifs that bind to other intracellular signaling proteins are provided, as well as nucleic acids encoding the same, cells that contain the same and methods of use. Examples of such motifs include a PLCγ1-binding motifs and TRAF binding motifs, but other motifs may be used. These motifs are thought to recruit other proteins to the engineered immune receptor, thereby altering cellular responses. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 18/274979 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464411 (20230501) A61K 2239/15 (20230501) A61K 2239/21 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/2809 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115610 | BHATNAGAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Parijat BHATNAGAR (Belmont, California); Marvin A. SSEMADAALI (Menlo Park, California) |
| ABSTRACT | An example antigen test device comprises a genetically engineered diagnostic cell comprising an exogenous polynucleotide sequence including a receptor element that encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain that recognizes an antigen on a surface of a pathogen-infected cell from a sample or on a surface of a virus particle associated with a pathogen from the sample, an actuator element that encodes a transcription factor binding site, and an effector element that encodes a detectable reporter protein, wherein, in response to the antigen binding domain of the CAR binding to the antigen, the genetically engineered diagnostic cell is configured to activate and to synthesize the detectable reporter protein. |
| FILED | Tuesday, June 13, 2023 |
| APPL NO | 18/333778 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/2803 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115649 | Garza et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis Garza (Baltimore, Maryland); Mohameed Islam (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of caspase inhibition. More specifically, the present invention provides compositions and methods utilizing caspase inhibitors to enhance injury repair and to treat bacterial and viral infections. In a specific embodiment, a method for treating a bacterial infection and skin lesions in a patient comprises the step of administering to the patient an effective amount of a caspase inhibitor. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/477878 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/05 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 7/00 (20180101) A61P 17/02 (20180101) A61P 31/04 (20180101) A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115651 | Wagner, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OP-T LLC (Aurora, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Hal Wagner, JR. (Denver, Colorado); Martin Glenn Yussman (Denver, Colorado); Charles W. Henry (Demver, Colorado); Gisela M. Vaitaitis (Centennial, Colorado) |
| ABSTRACT | Methods and materials for treating and preventing autoimmune diseases, in particular, multiple sclerosis (MS) including small peptides are capable of interacting with CD40, thereby altering and/or modulating the ability of CD40 to interact with CD154, which apparently affects inflammation; and/or the use of such peptides in reducing the inflammatory response, and in particular, the autoimmune inflammatory response; and/or the use of such short peptides to prevent or reverse autoimmune disease, and particularly, multiple sclerosis, in individuals; and/or methods and materials for detecting T-cells that express CD40 (Th40 cells). Also provided are kits for reducing inflammation, treating autoimmune diseases, or detecting Th40 cells. Additionally, methods and apparatuses to administer the peptide are provided. |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/368431 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 38/08 (20130101) Original (OR) Class A61K 38/10 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115653 | Chauhan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Anil K. Chauhan (Iowa City, Iowa); Nirav A. Dhanesha (Iowa City, Iowa) |
| ABSTRACT | The invention provides a method and kits for inhibiting integrin α9β1 activity comprising contacting integrin α9β1 or a binding partner of integrin α9β1 with an isolated anti-integrin α9 inhibitor, wherein the integrin α9β1 activity is inhibited. In certain aspects, the present invention provides a novel intervention by targeting integrin α9β1 with a functional blocking inhibitor (e.g., peptides or antibodies) to limit brain damage following reperfusion after ischemic stroke. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/379847 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) Original (OR) Class A61K 38/39 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 16/2842 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115662 | ATWOOD |
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| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin); UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig S. ATWOOD (Madison, Wisconsin) |
| ABSTRACT | Described herein are methods of inducing cognitive recovery of a subject suffering from a traumatic brain injury (TBI). The methods comprise administering to the subject pharmaceutical compositions including human chorionic gonadotropic (hCG) and/or luteinizing hormone (hLH), or a combination thereof. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 18/276871 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/57 (20130101) A61K 31/565 (20130101) A61K 31/567 (20130101) A61K 31/5685 (20130101) A61K 38/24 (20130101) Original (OR) Class A61K 38/1841 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115670 | Weiner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louis M. Weiner (Washington, District of Columbia); Allison Fitzgerald (Washington, District of Columbia) |
| ABSTRACT | Systems and methods are disclosed for the treatment of cancer. Specifically, techniques are disclosed for treating cancer through the administration of genetically modified immune cells that overexpress fibroblast activation protein. In other embodiments, the techniques include the treatment of cancer through the administration of fibroblast activation protein inhibitors to the tumor site. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 18/263129 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/195 (20130101) A61K 38/4813 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/4613 (20230501) A61K 39/4631 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115671 | Forbes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts); Ernest Pharmaceuticals, Inc. (Hadley, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neil S. Forbes (Hadley, Massachusetts); Vishnu Raman (Sunderland, Massachusetts); Nele Van Dessel (Easthampton, Massachusetts); Jeanne A. Hardy (Amherst, Massachusetts) |
| ABSTRACT | Provided herein is a bacterial delivery platform that harnesses mechanisms unique to Salmonella to intracellularly deliver protein-based drugs. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 18/276628 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 38/465 (20130101) A61K 38/4873 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/36 (20130101) C12N 9/16 (20130101) C12N 9/6472 (20130101) C12N 15/74 (20130101) C12N 2800/101 (20130101) C12N 2830/002 (20130101) Enzymes C12Y 301/04 (20130101) C12Y 304/22056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115672 | DANIAS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ioannis (John) DANIAS (Staten Island, New York) |
| ABSTRACT | Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/546236 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/49 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) Enzymes C12Y 304/21068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115674 | KALYANASUNDARAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois); PAI LIFE SCIENCES INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramaswamy KALYANASUNDARAM (Rockford, Illinois); Darrick CARTER (Seattle, Washington); Sean GRAY (Kent, Washington) |
| ABSTRACT | The present invention is a multivalent immunogenic composition for immunizing an animal against filariasis. In some aspects, the antigens of the multivalent immunogenic composition are protein-based, DNA-based, or a combination thereof. This invention also provides a method and kit for detecting a filarial nematode and determining vaccine efficacy. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/275463 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/0003 (20130101) Original (OR) Class A61K 2039/54 (20130101) A61K 2039/70 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/00 (20180101) Peptides C07K 14/4354 (20130101) Enzymes C12Y 111/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115676 | GUO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rita E. Serda (Albuquerque, New Mexico); Jimin Guo (Albuquerque, New Mexico); UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| INVENTOR(S) | JIMIN GUO (Albuquerque, New Mexico); RITA E. SERDA (Albuquerque, New Mexico) |
| ABSTRACT | In one aspect, a method generally includes obtaining a dried silicified cell that has been stored for at least 24 hours without cryopreservation and rehydrating the dried silicified cell in a pharmaceutically acceptable carrier. The method can further include surface modifying the silicified cell with at least one immunogenic molecule. The method can further include administering the rehydrated silicified cell to a subject. In some embodiment, the dried silicified cell has been stored for at least 14 days without cryopreservation. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject a chemotherapeutic agent effective to treat the tumor and administering to the subject a silicified cell vaccine effective to treat the tumor. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 18/267878 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 2039/5152 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115679 | Moon et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James J. Moon (Ann Arbor, Michigan); Rui Kuai (Ann Arbor, Michigan); Anna A. Schwendeman (Ann Arbor, Michigan); Jutaek Nam (Ann Arbor, Michigan) |
| ABSTRACT | The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings). |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529758 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 31/712 (20130101) A61K 31/713 (20130101) A61K 31/7088 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/00111 (20180801) A61K 39/001106 (20180801) A61K 39/001132 (20180801) A61K 39/001151 (20180801) A61K 39/001156 (20180801) A61K 39/001157 (20180801) A61K 39/001162 (20180801) A61K 39/001164 (20180801) A61K 39/001166 (20180801) A61K 39/001176 (20180801) A61K 39/001181 (20180801) A61K 39/001182 (20180801) A61K 39/001184 (20180801) A61K 39/001186 (20180801) A61K 39/001188 (20180801) A61K 39/001189 (20180801) A61K 39/001191 (20180801) A61K 39/001192 (20180801) A61K 39/001193 (20180801) A61K 39/001194 (20180801) A61K 39/001195 (20180801) A61K 39/001197 (20180801) A61K 45/06 (20130101) A61K 47/554 (20170801) A61K 47/6917 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/3515 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115684 | McNeel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Madison Vaccines Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Doug McNeel (Madison, Wisconsin); Richard Lesniewski (Madison, Wisconsin) |
| ABSTRACT | Provided herein is technology relating to cancer treatment and prevention and particularly, but not exclusively, to compositions and methods related to therapies for prostate cancer. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/492311 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/001163 (20180801) A61K 39/001193 (20180801) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/53 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/3069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115693 | Borriello et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Francesco Borriello (Arlington, Massachusetts); Ofer Levy (Cambtidge, Massachusetts); David J. Dowling (Milton, Massachusetts); Sirano Dhe-Paganon (Holliston, Massachusetts); Hyuk-Soo Seo (Boston, Massachusetts) |
| ABSTRACT | Provided herein are nanoparticles which enhance the immunogenicity of antigens for use in Beta coronavirus (e.g., MERS-CoV, SARS-CoV-1, or SARS-CoV-2) vaccines, as well as immunogenic compositions comprising the antigen nanoparticles and additional adjuvants for further enhancing immunogenicity. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 18/572163 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5169 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/64 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115697 | Marasco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne A. Marasco (Wellesley, Massachusetts); Quan Zhu (Southborough, Massachusetts); De-Kuan Chang (Boston, Massachusetts) |
| ABSTRACT | The present invention provides humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to the chemokine receptor CCR4. This antibody is derived from CCR4-IgG1 and recognizes the same epitope. This antibody contains either an IgG4 or a stabilized IgG4 in order to improve binding efficiency and reduce in vivo Fab arm exchange. Binding of the antibodies disclosed herein to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. |
| FILED | Thursday, June 22, 2023 |
| APPL NO | 18/213132 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/001106 (20180801) A61K 39/3955 (20130101) Original (OR) Class A61K 39/39558 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/18 (20130101) C07K 16/24 (20130101) C07K 16/246 (20130101) C07K 16/2809 (20130101) C07K 16/2866 (20130101) C07K 2317/31 (20130101) C07K 2317/33 (20130101) C07K 2317/35 (20130101) C07K 2317/52 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115699 | Theodorescu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| INVENTOR(S) | Dan Theodorescu (Los Angeles, California); Simon Knott (Topanga, California); Kenneth Gouin (Los Angeles, California); Nathan Ing (Los Angeles, California); Charles Rosser (Stevenson Ranch, California) |
| ABSTRACT | We combined single nuclei RNA sequencing with spatial transcriptomics and single-cell resolution spatial proteomic analysis of human bladder cancer to identify an epithelial subpopulation with therapeutic response prediction ability. These cells express Cadherin 12 (CDH12, N-Cadherin 2), catenins, and other epithelial markers. CDH12-enriched tumors define patients with poor outcome following surgery with or without neoadjuvant chemotherapy (NAC), whereas CDH12-enriched tumors have a superior response to immune checkpoint therapy (ICT). Patient stratification by tumor CDH12 enrichment offered better prediction outcome than established bladder cancer subtypes. The CDH12 population resembles an undifferentiated state with chemoresistance. CDH12-enriched cells express PD-L1 and PD-L2 and co-localize with exhausted T-cells, possibly mediated through CD49a (ITGA1), likely explaining ICT efficacy in these tumors. This invention identifies a cancer cell population with a diametric response to major bladder cancer therapeutics, and provides a framework for designing biomarker-guided clinical trials. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 18/289534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/475 (20130101) A61K 31/519 (20130101) A61K 31/704 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 39/3955 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115700 | KIPPS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas J. KIPPS (San Diego, California); Liguang CHEN (San Diego, California); Bing CUI (San Diego, California) |
| ABSTRACT | There are provided, inter alia, compositions and methods for treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a Bruton's tyrosine kinase (BTK) antagonist and a ROR-1 antagonist. Further provided are pharmaceutical compositions including a BTK antagonist, ROR-1 antagonist and a pharmaceutically acceptable excipient. In embodiments, the BTK antagonist is ibrutinib and the ROR-1 antagonist is cirmtuzumab. |
| FILED | Thursday, March 30, 2023 |
| APPL NO | 18/193062 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/519 (20130101) A61K 39/39558 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/2803 (20130101) C07K 2317/24 (20130101) C07K 2317/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115714 | FLYNN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GanNA Bio, Inc. (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Alexander FLYNN (Brookline, Massachusetts); Brian GOODMAN (Boston, Massachusetts); Ciaran LAWLOR (Milton, Massachusetts); Namita BISARIA (Somerville, Massachusetts); Richard D. CUMMINGS (Brookline, Massachusetts); Mohui WEI (Boston, Massachusetts); Carolyn R. BERTOZZI (Menlo Park, California) |
| ABSTRACT | The present disclosure relates to glyconucleic acids, such as glycoRNA and glycoDNA described herein. Provided are glycosylated ribonucleic acid (glycoRNA)-related methods and compositions. |
| FILED | Thursday, August 03, 2023 |
| APPL NO | 18/364753 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/61 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115722 | Pasqualini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); MBrace Therapeutics, Inc. (San Diego, California) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); MBrace Therapeutics, Inc. (San Diego, California) |
| INVENTOR(S) | Renata Pasqualini (Newark, New Jersey); Wadih Arap (Newark, New York); Fernanda I. Staquicini (Summit, New Jersey) |
| ABSTRACT | The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5). |
| FILED | Thursday, July 27, 2023 |
| APPL NO | 18/360287 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6811 (20170801) Original (OR) Class A61K 47/6889 (20170801) Peptides C07K 16/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115729 | Kelly, Ph.D. et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Kimberly A. Kelly, Ph.D. (Goochland, Virginia); Jessica Hung (Charlottesville, Virginia) |
| ABSTRACT | Provided are compositions that include targeting peptides and methods for using the same to treat and/or prevent various diseases, disorders, and/or conditions. In some embodiments, the compositions and methods relate to liposomal compositions that include a liposome, the surface of which is conjugated to a peptide having an amino acid sequence as set forth in any of SEQ ID NOS: 3-38, optionally wherein the liposome encapsulates a therapeutic agent or a detectable agent. In some embodiments, the peptide has an amino acid sequence that is one of SEQ ID NOs: 14, 19, 20, 27, and 28. Also provided are methods treating or preventing fibrosis, for decreasing the incidence of a disease, disorder, or condition associated with chronic pancreatitis (CP), for targeting active agents to targets, including but not limited to collagen III-expressing cells and extracellular matrix, and for decreasing incidence of side effects associated with apigenin treatment. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 18/276111 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 45/06 (20130101) A61K 47/605 (20170801) A61K 47/6911 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 5/00 (20180101) Peptides C07K 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115736 | Gendron et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tania Gendron (Jacksonville, Florida); Marka Van Blitterswijk (Jacksonville Beach, Florida) |
| ABSTRACT | Methods and materials for treating a mammal having a TDP-43 proteinopathy (a disorder characterized by the accumulation and/or aggregation of TDP-43 polypeptides in the central nervous system) are provided herein. For example, this document provides methods and materials for administering nucleic acids encoding polyadenylate-binding protein 4 (PABPC4) to a mammal having a TDP-43 proteinopathy, such that the level of PABPC4 in the central nervous system of the mammal is increased. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/276987 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115739 | QI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lei S. QI (Stanford, California); Lucie GUO (Stanford, California); Hannah KEMPTON (Stanford, California) |
| ABSTRACT | The present disclosure generally relates to engineered Cluster Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated (Cas) 12a proteins and system, and methods for use in gene editing and gene modulation for application to gene therapy. Related systems and methods of gene modulation are also disclosed. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/546177 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2320/32 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115740 | TSOURKAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); AlphaThera LLC (Philadelphia, Panama) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); AlphaThera LLC (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Andrew TSOURKAS (Bryn Mawr, Pennsylvania); Feifan YU (West Windsor, New Jersey) |
| ABSTRACT | This invention relates to the compositions and methods for labeling antibodies and other proteins and targeting agents with a helical bundle protein that is functionalized with cargo. Cargos can include but are not limited to fluorescent dyes, haptens (e.g. biotin), contrast agents (e.g. gadolinium, radionuclides), chelated metals, therapeutic agents, sensitizers, or other small molecules. Specifically, provided herein are compositions having a helical bundle, that has been labeled at precisely defined locations with cargo, and that can be conjugated, attached or fused to an antibody or other targeting agent. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 18/254851 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/16 (20130101) A61K 49/0032 (20130101) Original (OR) Class A61K 49/0056 (20130101) A61K 2123/00 (20130101) Peptides C07K 16/32 (20130101) C07K 16/2863 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115741 | GAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jinming GAO (Plano, Texas); Gang HUANG (Plano, Texas); Tian ZHAO (Irving, Texas); Xinpeng MA (Dallas, Texas); Yiguang WANG (Dallas, Texas); Yang LI (Dallas, Texas); Baran D. SUMER (Dallas, Texas) |
| ABSTRACT | The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug. |
| FILED | Monday, August 14, 2023 |
| APPL NO | 18/449675 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0021 (20130101) A61K 49/0032 (20130101) A61K 49/0041 (20130101) A61K 49/0054 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/30 (20130101) C08F 8/32 (20130101) C08F 8/34 (20130101) C08F 8/42 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 69/103 (20130101) C09B 69/105 (20130101) C09B 69/106 (20130101) C09B 69/109 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/643 (20130101) G01N 21/6428 (20130101) G01N 21/6456 (20130101) G01N 33/84 (20130101) G01N 33/582 (20130101) G01N 2021/6432 (20130101) G01N 2021/6439 (20130101) G01N 2021/6441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115742 | Montclare et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin Kim Montclare (New York, New York); Dustin Britton (Brooklyn, New York); Youssef Zaim Wadghiri (New York, New York); Farbod Mahmoudinobar (Harrison, New Jersey) |
| ABSTRACT | Provided are proteins/peptides. The proteins or peptides comprise a sequence designed by the methods described herein. The proteins and peptides may have one or more trifluoroleucine (LTF, which may be referred to as TFL or LTF throughout) residues. The proteins may have or contain the following sequence: VX1X2X3X4X5X6X7X8X9X10X11X12X13X14X15X16X17X18X19X20X21X22X23X24X25X26X27X28X29X30X31X32X33X34X35X36X37 (SEQ ID NO:1), where X1 is A, E, D, R, H, K, Q, N, or S; X2 is A, E, N, or Q; X3 is A, V, L, I, Q, M, or LT; X4 is A, E, R, D, H, I, L, T, K, Q, N, or LT; X5 is A, F, Q, R, K, H, D, S, or E; X6 is A, L, I, or LTF; X7 is A, K, or E; X8 is A, K, E, D, R, H, Q, or N; X9 is A, T, I, L, Q, or LTF; X10 is A, L, I, or LT; X11 is A, E, D, H, P, I, L, K, Y, N, Q, R, or LT; X12 is A, Q, H, E, D, K, R, or N; X13 is A, M, I, L, Q, T, or LTF; X14 is A, L, D, E, K, I, or LTF; X15 is A, E, D, H, Y, I, L, R, K, Q, N, or Lu; X16 is A, E, or Q; X17 is A, L, M, I, V, or LTF; X18 is A, K, E, D, K, R, H, N, or Q; X19 is A, N, D, K, R, H, Q, or E; X20 is A, L, T, I, M, R, or LTF; X21 is A, N, or Q; X22 is K, A, E, I, L, M, R, H, D, Q, N, S, or LTF; X23 is A, Q, N, I, L, or LTF; X24 is A, L, I, M, T, or LT; X25 is A, H, Q, R, K, D, N, Y, I, E, L, T, or LT; X26 is A, D, E, R, K, Q, H, N, or T; X27 is A, V, I, Q, L, T, or LTF; X28 is A, R, E, D, K, H, N, Q, or T; X29 is A, H, E, R, D, K, I, L, N, Q, T, Y, or LTF; X30 is L, A, D, K, I, N, Q, or LTF; X31 is A, L, Q, I, or LTF; X32 is E, D, K, H, N, Q, A, L, R, I, Y, or LTF; X33 is A, N, Q, D, E, H, K, R, or S; X34 is Q, I, L, A, M, or LT; X35 is S, A, P, or Q; X36 is A, K, T, D, R, H, N, Q, or E; X37 is A, L, I, K, D, N, Q, R, or LTF; where at least one of X3, X4, X6, X9, X10, X11, X13, X14, X15, X16, X17, X20, X22, X23, X24, X25, X27, X29, X30, X31, X32, X34, X37 or any L is replaced with LTF. The proteins and peptides may have desirable self-assembling properties such that they form supramolecular structures (e.g., fibers or fibrils). The supramolecular structures may further gelate water such that a hydrogel is formed. The fibers and/or gels may be used to deliver drugs and/or as theranostic agents. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/460519 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/14 (20130101) A61K 49/222 (20130101) A61K 49/1884 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Peptides C07K 14/245 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/08 (20130101) G01N 29/34 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115744 | Caravan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Peter CARAVAN (Cambridge, Massachusetts); Thomas J. MCMURRY (Winchester, Massachusetts); Richard J. LOOBY (Reading, Massachusetts); Collagen Medical, LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Caravan (Cambridge, Massachusetts); Thomas J. McMurry (Winchester, Massachusetts); Richard J. Looby (Reading, Massachusetts) |
| ABSTRACT | This disclosure relates to compounds of Formula IV: for fibrin imaging, wherein the compounds comprise an imaging or therapeutic radioisotope. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/767956 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 51/088 (20130101) Original (OR) Class A61K 51/0482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115770 | Heo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Su Chin Heo (Philadelphia, Pennsylvania); Zizhao Li (Philadelphia, Pennsylvania); Se-Hwan Lee (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides a tunable porous fibrous scaffold composition, comprising one or more modified glycosaminoglycans; and (ii) one or more extracellular matrix (ECM) proteins. The present disclosure also provides methods for preparing the tunable porous fibrous scaffold composition described herein. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482096 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/38 (20130101) A61L 27/52 (20130101) Original (OR) Class Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115859 | STEINHARDT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Cynthia STEINHARDT (Penn Valley, Pennsylvania); Gene FRIDMAN (Baltimore, Maryland) |
| ABSTRACT | A system and method for neural implant processing is disclosed. The method includes receiving, at a receiver of a neural implant, an input activation pattern; processing, by a front-end processing algorithm, the input activation pattern to produce a target population firing pattern for one or more neurons; and transforming, by a back-end processing algorithm, the target population firing pattern to a simulation pattern that induces a response with naturalistic timing. The neural implant includes a cochlear implant, a vestibular implant, a retinal vision prostheses, a deep brain stimulator, or a spinal cord stimulator. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/277179 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0543 (20130101) A61N 1/36038 (20170801) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 25/606 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115881 | Howell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Roger W. Howell (Hampton, New Jersey); Sumudu Katugampola (Lincoln, Nebraska); Jianchao Wang (Newark, New Jersey) |
| ABSTRACT | A system, method and computer program product to determine radiation dose from radionuclides used to treat a patient in need thereof. The present invention allows users to visualize and understand the impact of radionuclide choice, distribution of activity in the cell, distribution of activity among the cells, cell dimensions, cell separation distance, cluster size, and radiobiological response parameters on the capacity to kill populations of cells. All of these parameters can play a substantial role in determining the surviving fraction of cells. Accordingly, this system, method and computer program product can assist in designing treatment plans for therapeutic radiopharmaceuticals suited to individual needs. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/476134 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1031 (20130101) Original (OR) Class A61N 2005/1034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116856 | Shen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Young BioPharma, LLC (Lowell, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Young Shen (Andover, Massachusetts); Junke Liu (Jamaica Plain, Massachusetts) |
| ABSTRACT | The present invention provides compositions comprising compounds having formulas (I), (II) or and additionally provides methods for the use thereof in the treatment of various disorders including neurological disorders, cancer, diabetes, and obesity, wherein R1-R7, X, A, and Q in (I), R1-R15 in (II) and R1-R15 in (III) are as defined herein. In certain embodiments, methods for the treatment of various disorders including pain and cancer comprise topically, locally or systemically (e.g., IV, IP or orally) administering to a subject in need thereof a therapeutically effective amount of a compound of formulas (I), (II) or (III). |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 18/035697 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/04 (20180101) A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 235/20 (20130101) C07C 235/24 (20130101) Original (OR) Class C07C 237/20 (20130101) C07C 255/63 (20130101) C07C 311/30 (20130101) Heterocyclic Compounds C07D 211/26 (20130101) C07D 263/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116857 | WALKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | St. Louis University (St. Louis, Missouri); The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | Saint Louis University (St. Louis, Missouri); The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| INVENTOR(S) | John K. WALKER (St. Louis, Missouri); Valentin V. RYBENKOV (Norman, Oklahoma); Ramakumar KINTHADA (St. Louis, Missouri); Hang ZHAO (Norman, Oklahoma); Elena I. ZGURSKAYA (Norman, Oklahoma); Terri BOEHM (St. Louis, Missouri); Zoya PETRUSHENKO (Norman, Oklahoma) |
| ABSTRACT | In one aspect, the present disclosure provides compounds such as those with one or more quaternary ammonium ions joined by one or more aromatic rings. These compounds may have a formula: These compounds may be used in the treatment of a microbial infection such as a bacterial infection including infections of drug resistant strains of bacteria. |
| FILED | Thursday, July 06, 2023 |
| APPL NO | 18/348207 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Acyclic or Carbocyclic Compounds C07C 255/51 (20130101) Original (OR) Class C07C 317/40 (20130101) Heterocyclic Compounds C07D 249/04 (20130101) C07D 295/155 (20130101) C07D 401/12 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116865 | Ghosh et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Monika Yadav (West Lafayette, Indiana); Andrew Mesecar (West Lafayette, Indiana) |
| ABSTRACT | Inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504660 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/26 (20130101) Original (OR) Class C07D 227/087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116875 | Scheidt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl A. Scheidt (Evanston, Illinois); Hidayatullah G. Munshi (Evanston, Illinois); Ada Jade Kwong (Evanston, Illinois); Thao Nguyen Doan Pham (Evanston, Illinois) |
| ABSTRACT | Disclosed are indazole compounds and derivatives thereof for use as modulators of the activity of mitogen-activated protein kinase 4 (MEK4). The disclosed compounds include 3-arylindazoles and 3-amino-indazoles which may be formulated in pharmaceutical composition for treating cell proliferative diseases and disorders associated with MEK4 activity, including cancer. |
| FILED | Wednesday, September 13, 2023 |
| APPL NO | 18/466599 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 231/56 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116879 | Hargrove et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); Case Western Reserve University (Cleveland, Ohio); Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina); Case Western Reserve University (Cleveland, Ohio); Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Amanda Hargrove (Durham, North Carolina); Blanton Tolbert (Cleveland, Ohio); Gary Brewer (New Brunswick, New Jersey); Neeraj Narendra Patwardhan (Durham, North Carolina); Mei-Ling Li (New Brunswick, New Jersey) |
| ABSTRACT | The present disclosure describes, in part, compositions comprising derivatives and methods of using the same in prevention or treatment of viral infections in a subject. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 18/039917 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Heterocyclic Compounds C07D 241/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116893 | Scarneo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Scarneo (Durham, North Carolina); Philip F. Hughes (Durham, North Carolina); Andrea Neely (Durham, North Carolina); Timothy A.J. Haystead (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides compounds according to Formula (I), wherein X, R2, R3, R4, and R5 are defined herein. Further disclosed herein are pharmaceutical compositions, orally administrable dosage forms, and methods for using such compounds in the treatment of various diseases and disorders including inflammation, autoimmune disorders, chronic pain and cancer. In particular embodiments, the present disclosure provides orally bioavailable compounds capable of selectively modulating an activity (e.g., inhibition) of the serine/threonine protein kinase TAK1 and/or related kinases. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 18/273843 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 19/02 (20180101) A61P 25/02 (20180101) Heterocyclic Compounds C07D 401/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116908 | Wender et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Wender (Menlo Park, California); Ryan Quiroz (Boston, Massachusetts); Stephen Ho (Stanford, California); Akira Shimizu (Stanford, California); Steven Ryckbosch (Albany, California); Matthew C. Stevens (Atherton, California); Matthew S. Jeffreys (King of Prussia, Pennsylvania); Clayton Hardman (Stanford, California); Jack Sloane (Stanford, California) |
| ABSTRACT | Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/241636 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/351 (20130101) A61K 31/365 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 31/18 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 407/14 (20130101) Original (OR) Class C07D 493/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116911 | Hergenrother et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Paul J. Hergenrother (Champaign, Illinois); Emily Jane Geddes (Urbana, Illinois); Bryon Shane Drown (Champaign, Illinois); Stephen E. Motika (Urbana, Illinois); Erica Nicole Parker (Urbana, Illinois) |
| ABSTRACT | Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, such as Gram-negative bacterial infections. Compounds selected for conversion to potential Gram-negative antibacterial compounds were identified based on compounds having low globularity and low flexibility. Amine substituents were then strategically added to the selected compounds to provide compounds having antibacterial activity against Gram-negative bacteria. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/344336 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 409/14 (20130101) Original (OR) Class C07D 471/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116944 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell Davis (Salt Lake City, Utah); Shuanghu Liu (Salt Lake City, Utah) |
| ABSTRACT | The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus, respiratory syntactical virus (RSV), Rift Valley fever, Influenza virus, Tacaribe virus, Mayaro virus, West Nile virus, yellow fever virus, and coronavirus), and disorders of uncontrolled cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/388765 |
| CURRENT CPC | Heterocyclic Compounds C07D 235/30 (20130101) C07D 487/04 (20130101) C07D 491/048 (20130101) C07D 491/052 (20130101) C07D 491/147 (20130101) Original (OR) Class C07D 495/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116972 | Moukha-Chafiq et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Southern Research Institute (Birmingham, Alabama); Oregon Health and Science University (Portland, Oregon); Washington University in St. Louis (St. Louis, Missouri); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Moukha-Chafiq (Hoover, Alabama); Ashish Kumar Pathak (Birmingham, Alabama); Shuklendu D. Karyakarte (Birmingham, Alabama); Larry D. Bratton (Birmingham, Alabama); Corinne E. Augelli-Szafran (Homewood, Alabama); Michael Diamond (St. Louis, Missouri); Pei Yong Shi (Galveston, Texas); Alec Jay Hirsch (Portland, Oregon); Jessica Lee Smith (Beaverton, Oregon); Daniel Streblow (Banks, Oregon); Nicole Haese (Beaverton, Oregon); Baoling Ying (Ballwin, Missouri) |
| ABSTRACT | The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/510128 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116990 | BURNETT, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | John C. BURNETT, Jr. (Rochester, Minnesota); Shuchong PAN (Rochester, Minnesota); Sasantha Jeson SANGARALINGHAM (Rochester, Minnesota); Ye ZHENG (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials related to selected engineered analogs of atrial natriuretic peptides. For example, this document provides compositions that contain one or more selected engineered analogs of atrial natriuretic peptides provided herein and that have the ability to treat, prevent, or alleviate the symptoms of cardiovascular, cardiorenal, and metabolic disease. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/467797 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/341 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) Peptides C07K 14/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116996 | FINKLESTEIN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Recovery Therapeutics, Inc. (Needham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seth P. FINKLESTEIN (Needham, Massachusetts) |
| ABSTRACT | The disclosure provides methods of treating an infection by a coronavirus with a fibroblast growth factor (“FGF”). Also provided herein are FGFs for treating an infection by a coronavirus and their use in the manufacture of a medicament for treating an infection by a coronavirus. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 18/286316 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/706 (20130101) A61K 31/727 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/503 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117011 | Misasi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | John Misasi (Kensington, Maryland); Lingshu Wang (North Potomac, Maryland); Chaim Aryeh Schramm (New York, New York); John R. Mascola (Rockville, Maryland); Daniel Cesar Douek (Bethesda, Maryland); Nancy J. Sullivan (Brookline, Massachusetts); Amy Ransier Henry (Monrovia, Maryland); Tongqing Zhou (Boyds, Maryland); Peter D. Kwong (Washington, District of Columbia); Wei Shi (Rockville, Maryland); Yi Zhang (North Potomac, Maryland); Eun Sung Yang (Bethesda, Maryland); Mario Roederer (Bethesda, Maryland); Rosemarie Diana Mason (Washington, District of Columbia); Amarendra Pegu (Rockville, Maryland); Julie E. Ledgerwood (Bethesda, Maryland) |
| ABSTRACT | Disclosed are monoclonal antibodies, antigen binding fragments, and bi-specific antibodies that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclosed are methods for detecting a coronavirus, such as SARS-CoV-2, in a biological sample, using the disclosed antibodies. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 18/263995 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1003 (20230801) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117013 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Wilson (Chicago, Illinois); Yaoqing Chen (Chicago, Illinois); Haley L. Dugan (Chicago, Illinois) |
| ABSTRACT | Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335869 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117014 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Wilson (Chicago, Illinois); Yaoqing Chen (Chicago, Illinois); Haley L. Dugan (Chicago, Illinois) |
| ABSTRACT | Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335872 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117015 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Wilson (Chicago, Illinois); Yaoqing Chen (Chicago, Illinois); Haley L. Dugan (Chicago, Illinois) |
| ABSTRACT | Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335874 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117016 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Wilson (Chicago, Illinois); Yaoqing Chen (Chicago, Illinois); Haley L. Dugan (Chicago, Illinois) |
| ABSTRACT | Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335876 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117018 | Sajadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United States Government as Represented by the Department of Veterans Affairs (Washington, D.C., District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Sajadi (Cockeysville, Maryland); George K. Lewis (Baltimore, Maryland); Anthony DeVico (Alexandria, Virginia) |
| ABSTRACT | The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof. |
| FILED | Tuesday, May 09, 2023 |
| APPL NO | 18/314490 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) C07K 2317/565 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117019 | Mousa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| INVENTOR(S) | Jarrod Mousa (Athens, Georgia); Aaron Gingerich (Athens, Georgia); Jiachen Huang (Athens, Georgia); Fredejah Royer (Athens, Georgia); Fikri Y. Avci (Watkinsville, Georgia) |
| ABSTRACT | Monoclonal antibodies and antigen binding fragments that specifically bind pneumococcal proteins, specifically pneumococcal histidine triad protein (PhtD) and pneumococcal surface protein A (PspA), are provided. Also disclosed are nucleic acid molecules encoding the antibody, antigen binding fragment, a VH or VL of the antibody, or a multipiece antibody including the VH and/or VL, vectors including these nucleic acid molecules, and host cells transfected with these vectors. Methods of inhibiting, treating, and detecting a Streptococcus pneumoniae infection are also provided. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 18/264733 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/1275 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/31 (20130101) C07K 2317/94 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56944 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117026 | Seder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); Sanaria Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); Sanaria Inc. (Rockville, Maryland) |
| INVENTOR(S) | Robert Seder (Chevy Chase, Maryland); Neville Kisalu (Bethesda, Maryland); Azza Idris (Bethesda, Maryland); Barbara Flynn (Bethesda, Maryland); Stephen Hoffman (Rockville, Maryland) |
| ABSTRACT | Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection. |
| FILED | Wednesday, August 02, 2023 |
| APPL NO | 18/364104 |
| CURRENT CPC | Peptides C07K 16/205 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117033 | GU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Chengua GU (Cambridge, Massachusetts); Benjamin ANDREONE (Cambridge, Massachusetts); Urs LANGEN (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to compositions comprising antibodies and antibody reagent that binds specifically to Mfsd2A and method of using such compositions, e.g., to increase blood-brain barrier permeability in therapeutic methods. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 18/269018 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/6849 (20170801) Peptides C07K 14/7051 (20130101) C07K 16/28 (20130101) Original (OR) Class C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117047 | KIPPS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas J. KIPPS (San Diego, California); Charles E. PRUSSAK (San Diego, California); George F. WIDHOPF, II (San Diego, California) |
| ABSTRACT | Provided herein are, inter alia, antibodies (e.g. humanized antibodies, monoclonal antibodies, antibody fragments (e.g., scFvs) and antibody compositions (e.g., chimeric antigen receptors, bispecific antibodies), which bind human tyrosine kinase-like orphan receptor 1 (ROR1) with high efficiency and specificity. The antibodies and antibody compositions provided herein include novel light and heavy chain domain CDRs and framework regions and are, inter alia, useful for diagnosing and treating cancer and other ROR1-related diseases. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/546081 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6849 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) G01N 33/6854 (20130101) G01N 2333/70567 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117292 | ENTCHEVA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emilia ENTCHEVA (Washington, District of Columbia); Christianne Joan CHUA (Washington, District of Columbia) |
| ABSTRACT | Embodiments of the instant disclosure relate to compositions and methods of use thereof that allow for faster integration of acute cardiac pacing experiments compared to the direct genetic modification methods currently in use. Embodiments provided herein provide for spheroids that may be stored, transported, and deployed on site to confer optical pacing of cardiac tissue for use in high-throughput functional in vitro screening assays. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/509951 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/362 (20130101) Apparatus for Enzymology or Microbiology; C12M 35/02 (20130101) Original (OR) Class C12M 35/04 (20130101) C12M 35/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117300 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marshall University Research Corporation (Huntington, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongwei D. Yu (Huntington, West Virginia); Meagan E. Valentine (Huntington, West Virginia); Richard M. Niles (Huntington, West Virginia); Thomas Ryan Withers (Huntington, West Virginia); Brandon D. Kirby (Huntington, West Virginia) |
| ABSTRACT | Bacterial cultures are provided that comprise a modified Pseudomonas aeruginosa bacterium missing or deficient in two or more virulence factors. The two or more virulence factors can be selected from exotoxin A, hemolytic phospholipase C, phenazine-specific methyltransferase, alpha-1,3-rhamnosyltransferase, and 3-phosphoshikimate 1-carboxyvinyltransferase. Certain of the modified Pseudomonas aeruginosa bacteria are also missing or deficient in one or more alginate acetylation enzymes including the alginate O-acetyltransferases AlgI, AlgJ, AlgF, AlgX, and/or the C5-mannuronan epimerase AlgG. Methods of producing alginate are also provided along with compositions comprising alginate produced by the modified Pseudomonas aeruginosa bacteria. |
| FILED | Thursday, November 30, 2023 |
| APPL NO | 18/524494 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 5/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/205 (20210501) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/38 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117312 | Ng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Hon Man Alex Ng (Cambridge, Massachusetts); George M. Church (Cambridge, Massachusetts); Volker Busskamp (Cambridge, Massachusetts) |
| ABSTRACT | Forced expression of a handful of transcription factors (TFs) can induce conversion between cell identities; however, the extent to which TFs can alter cell identity has not been systematic ally assessed. Here, we assembled a “human TFome,” a comprehensive expression library of 1,578 human TF clones with fall coverage of the major TF families. By systematically screening the human TFome, we identified many individual TFs that induce loss of human-induced-pluripotent-stem-cell (hiPSC) identity, suggesting a pervasive ability for TFs to alter cell identity. Using large-scale computational cell type classification trained on thousands of tissue expression pantiles, we identified cell types generated by these TFs with high efficiency and speed, without additional selections or mechanical perturbations. TF expression in adult human tissues only correlated with some of the cell lineage generated, suggesting more complexity than observation studies can explain. |
| FILED | Thursday, May 18, 2023 |
| APPL NO | 18/319679 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/35 (20130101) Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0652 (20130101) Original (OR) Class C12N 2501/60 (20130101) C12N 2506/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117357 | Zervos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | Antonis S. Zervos (Orlando, Florida); Lucia Cilenti (Orlando, Florida) |
| ABSTRACT | A novel molecular pathway involving the MUL1 E3 ubiquitin ligase that regulates mitochondrial metabolism including regulation of lipogenesis and adiposity has been discovered. The significance of this pathway is exemplified in animals in which Mul1 is inactivated. These animals have a metabolic phenotype, and they are resistant to high fat diet (HFD)-induced obesity. Applications include an inactivator of mitochondrial Mul1 E3 ubiquitin ligase, compositions/kits including this inactivator, and methods for using this inactivator to regulate/inactivate mitochondrial Mul1 E3 ubiquitin ligase for prevention and/or treatment of conditions such as weight gain, obesity, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD). |
| FILED | Friday, June 02, 2023 |
| APPL NO | 18/328381 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/201 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/20 (20170501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 33/92 (20130101) G01N 33/5067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117358 | Gioeli |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlotteville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Daniel G. Gioeli (Charlottesville, Virginia) |
| ABSTRACT | Provided herein is a previously unannotated IncRNA lying within exon six and 3′UTR of the LCK gene, labeled “HULLK” for Hormone-Upregulated IncRNA within LCK. HULLK is a novel IncRNA situated within the LCK gene that can serve as an oncogene in PCa. Accordingly, provided are methods and compositions for diagnosing and treating prostate cancer based on HULLK that regulates prostate cancer cell growth. |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/487818 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117360 | Roth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore Lee Roth (San Francisco, California); Alexander Marson (San Francisco, California) |
| ABSTRACT | Provided herein are methods and compositions for editing the genome of a cell. In some embodiments, a nucleotide sequence of at least 200 nucleotides in length is inserted into a target region in the genome of a cell. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/463589 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2320/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117363 | ROMESBERG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Floyd E. ROMESBERG (La Jolla, California); Brian LAMB (San Diego, California); Yorke ZHANG (San Diego, California) |
| ABSTRACT | Disclosed herein are methods, cells, engineered microorganisms, and kits for increased production of a nucleic acid molecule that comprises an unnatural nucleotide. |
| FILED | Monday, July 31, 2023 |
| APPL NO | 18/228251 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/10 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) Original (OR) Class C12N 15/70 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117364 | KIANI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samira KIANI (Scottsdale, Arizona); Mo Reza EBRAHIMKHANI (Scottsdale, Arizona); Farzaneh MOGHADAM (Tempe, Arizona) |
| ABSTRACT | Provided herein are CRISPR-based synthetic repression systems as well as methods and compositions using the synthetic repression systems to treat septicemia, an adverse immune response in a subject and Waldenström macroglobulinemia. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535658 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) Peptides C07K 14/4703 (20130101) C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) C12N 2830/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117365 | Zhang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. |
| FILED | Wednesday, August 23, 2023 |
| APPL NO | 18/454343 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/74 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/746 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 15/8509 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 20/30 (20190201) G16B 20/50 (20190201) G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117376 | Mao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hai-Quan Mao (Baltimore, Maryland); Yining Zhu (Baltimore, Maryland); Yizong Hu (Baltimore, Maryland) |
| ABSTRACT | A scalable method for producing DNA/polycation particles having an optimal, defined particle size with multiple virus assembly plasmids for efficient transfection of viral production cells in suspension cultures. The presently disclosed DNA/polycation particles yield superior and reproducible transfection activity and shelf stability in the suspension form and can be used as an off-the-shelf product. The presently disclosed DNA/polycation particle formulation can potentially simplify and streamline the viral manufacturing process and improve production quality and consistency. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/546222 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0686 (20130101) C12N 7/00 (20130101) C12N 15/85 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117377 | Gore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Allen Institute (Seattle, Washington) |
| ASSIGNEE(S) | Allen Institute (Seattle, Washington) |
| INVENTOR(S) | Bryan Gore (Seattle, Washington); Edward Sebastian Lein (Seattle, Washington); Boaz P. Levi (Seattle, Washington); Deja Machen (Seattle, Washington); Refugio Martinez (Seattle, Washington); John K. Mich (Seattle, Washington); Jonathan Ting (Seattle, Washington) |
| ABSTRACT | Artificial expression constructs for modulating gene expression in GABAergic neurons and astrocytes are described. The artificial expression constructs can be used to express SLC6A1 for the treatment of SLC6A1-associated disorders, among other uses. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/263930 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117378 | VANDENBERGHE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Luk VANDENBERGHE (Weston, Massachusetts); Guangping GAO (Westborough, Massachusetts); James M. WILSON (Philadelphia, Pennsylvania) |
| ABSTRACT | A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345191 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0091 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) C12N 2750/14143 (20130101) C12N 2750/14152 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117382 | Cox et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Benjamin Turitz Cox (Cambridge, Massachusetts); James E. Dahlman (Cambridge, Massachusetts); Feng Zhang (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488197 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/43 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) C12N 9/96 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/1082 (20130101) C12N 2310/10 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117389 | UM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (Seoul, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Youngsoon UM (Seoul, South Korea); Deurim YUN (Seoul, South Korea); Sun Mi LEE (Seoul, South Korea); Gyeongtaek GONG (Seoul, South Korea); Ja Kyong KO (Seoul, South Korea); Jung Ho AHN (Seoul, South Korea) |
| ABSTRACT | The present disclosure is to provide a method capable of producing an organic acid in high yield from an acetic acid strain using synthesis gas as a substrate. According to the present disclosure, the productivity of metabolites with C2 to C6 carbon atoms derived from synthesis gas and the selectivity of hexanoic acid production among metabolites can be improved through a first fermentation step of simultaneously providing a substrate comprising synthesis gas and sugar; and a second fermentation step of semi-mixotrophic fermentation of providing only the substrate comprising the synthesis gas. Therefore, the disclosure can contribute to sustainable chemical production using synthesis gas. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470284 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/02 (20130101) C12P 7/16 (20130101) C12P 7/40 (20130101) Original (OR) Class C12P 7/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117415 | Varley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katherine E. Varley (Salt Lake City, Utah); Ryan Miller (Salt Lake City, Utah); Jeffery A. Greenland (Salt Lake City, Utah) |
| ABSTRACT | Disclosed herein are compositions and methods to detect and quantify low levels of methylated DNA in biological samples. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/766489 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117427 | Xie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoliang Sunney Xie (Lexington, Massachusetts); Katsuyuki Shiroguchi (Arlington, Massachusetts); Peter A. Sims (Cambridge, Massachusetts); Tony Z. Jia (Cambridge, Massachusetts) |
| ABSTRACT | Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided. |
| FILED | Monday, December 04, 2023 |
| APPL NO | 18/527896 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) C12N 2320/10 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117431 | Blurton-Jones et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mathew Blurton-Jones (Irvine, California); Jean Paul Chadarevian (Irvine, California); Robert Spitale (Irvine, California); Sunil Gandhi (Irvine, California); Kim Nguyen (Irvine, California) |
| ABSTRACT | The present invention relates to the development of and use of genetically modified human differentiated cells coupled with xenotransplantation into animal models to identify injury and disease-specific RNA and/or protein biomarkers. Specifically, the present invention encompasses two complementary methods for biomarker discovery that enable the direct and selective labelling, isolation, and analysis of human-specific RNA and/or proteins from xenotransplantation (or chimeric) animal models. Both methods involve the treatment of animal models with an RNA analog and/or amino acid analog that enables the specific isolation and quantification of human RNAs and/or proteins for the identification of novel human biomarkers for a large array of human injuries and diseases. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 18/000564 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) A01K 2267/0312 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) C12N 9/12 (20130101) C12N 9/93 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6883 (20130101) Original (OR) Class Enzymes C12Y 601/0101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117446 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huiying Li (Los Angeles, California); Shuta Tomida (Santa Monica, California); Robert L. Modlin (Sherman Oaks, California); Jeffery F. Miller (Santa Monica, California); Sorel T. Fitz-Gibbon (Los Angeles, California) |
| ABSTRACT | Methods of diagnosing and treating patients afflicted with acne, including diagnosing one as having acne if the individual possesses RT4, RT5, RT7, RT8, RT9, or RT10. Methods for treating acne include administering an effective amount of a drug specifically targeting RT4, RT5, RT7, RT8, RT9, or RT10, such as small molecules, antisense molecules, siRNAs, biologics, antibodies, phages, vaccines, or combination thereof. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/217206 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 35/741 (20130101) A61K 39/05 (20130101) A61K 39/0208 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2795/00032 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/701 (20130101) C12Q 1/6883 (20130101) C12Q 2600/16 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117452 | Warrick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Salus Discovery, LLC (Madison, Wisconsin); Flambeau Diagnostics, LLC (Monona, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Warrick (Madison, Wisconsin); Brianna Mullins (Deforest, Wisconsin); Patrick McMinn (Madison, Wisconsin); Dave Beebe (Monona, Wisconsin); Ryan Shogren (Madison, Wisconsin); Mitch Geiger (Madison, Wisconsin); Franklin Zhong (Madison, Wisconsin); Duane S. Juang (Madison, Wisconsin); Terry D. Juang (Madison, Wisconsin) |
| ABSTRACT | Provided herein are systems and methods for isolating a target from a biological sample. In some aspects, provided herein are automated systems and methods for isolating a target from a plurality of biological samples. For example, provided herein are automated systems and methods for isolating viral nucleic acid from a biological sample using a magnetic force to draw the nucleic acid out of a liquid biological sample. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 18/270440 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0237 (20130101) B01L 3/5085 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6844 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118210 | Arepally et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gowthami Arepally (Durham, North Carolina); Samuel Francis (Durham, North Carolina); Christopher Hwu (Corona, New York); Dalibor Sames (New York, New York); David Sulzer (New York, New York) |
| ABSTRACT | Disclosed herein are methods of diagnosing a disease or condition associated with abnormal platelet activation in a subject. Also disclosed herein are methods for assessing the propensity of donor platelets to release an uptaken fluorescent false neurotransmitter (FFN). |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 18/263764 |
| CURRENT CPC | Heterocyclic Compounds C07D 221/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) Original (OR) Class G01N 33/53 (20130101) G01N 2400/40 (20130101) G01N 2800/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118259 | HICKMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James HICKMAN (Orlando, Florida); Maria STANCESCU (Orlando, Florida); Peter MOLNAR (Orlando, Florida); Christopher LONG (Orlando, Florida); Christopher McAleer (Orlando, Florida) |
| ABSTRACT | In an aspect, disclosed herein are physiological devices and systems, and components thereof, used to evaluate cardiac parameters and arrhythmogenic mechanisms. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, March 24, 2023 |
| APPL NO | 18/125879 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 41/48 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4836 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118267 | Viola et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hannah VIOLA (Atlanta, Georgia); Jocelyn R. GRUNWELL (Atlanta, Georgia); Shuichi TAKAYMA (Atlanta, Georgia); Rabindra TIROUVANZIAM (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia); Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hannah Viola (Atlanta, Georgia); Jocelyn R. Grunwell (Atlanta, Georgia); Shuichi Takayama (Atlanta, Gabon); Rabindra Tirouvanziam (Atlanta, Georgia) |
| ABSTRACT | High-throughput co-culture models, for example, relevant to the cell barrier interface, are disclosed that employ under-side cell seeding in a miniaturized and automated system and process. The seeding method, which can be implemented in a scalable and low-cost manner, can eliminate the need for an inversion process by adjusting/optimizing the density of the cell suspension medium to float cells of interest so they can attach under a membrane. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/280393 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0688 (20130101) C12N 2500/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5029 (20130101) Original (OR) Class G01N 33/5044 (20130101) G01N 2800/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118281 | Law et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Brian Keith Law (Gainesville, Florida); Ronald K. Castellano (Gainesville, Florida) |
| ABSTRACT | Provided are compositions and methods of treating cell proliferative disorders, especially cancer. Also provided are methods for assessing and monitoring cell proliferative processes and processes for amelioration of cell proliferative disorders, especially cancer. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 18/271584 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 339/08 (20130101) C07D 495/04 (20130101) C07D 519/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118289 | Singbartl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Singbartl (Pittsburgh, Pennsylvania); John A. Kellum (Pittsburgh, Pennsylvania) |
| ABSTRACT | This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor β1 can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/321405 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2333/495 (20130101) G01N 2333/70578 (20130101) G01N 2400/40 (20130101) G01N 2800/50 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118439 | GOLDAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amirhossein GOLDAN (Stony Brook, New York); Andrew LABELLA (New Rochelle, New York); Wei ZHAO (East Setauket, New York); Anthony LUBINSKY (Port Jefferson Station, New York) |
| ABSTRACT | Provided are a device for detecting sub-atomic particles and method of fabrication thereof. The device includes a plurality of scintillators, a detector provided on a first end of the plurality of scintillators and a prismatoid provided on a second end of the plurality of scintillators. The prismatoid redirects light between adjacent scintillators of the plurality of scintillators. |
| FILED | Monday, December 04, 2023 |
| APPL NO | 18/528304 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/1644 (20130101) G01T 1/2002 (20130101) G01T 1/2985 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118452 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Weijian Yang (Redwood City, California); Junjie Hu (Davis, California) |
| ABSTRACT | A metalens and a metalens array having a bounded angular field of view are disclosed. The metalens includes a substrate and a two-dimensional (2D) grid over the substrate to divide the substrate into a 2D array of meta-units. Each meta-unit in the 2D array includes a nanostructure and a portion of the substrate that supports the nanostructure. Moreover, each meta-unit is configured with an angular-dependent transmission or reflection coefficient that decreases with an increasing incident angle of an illumination. Moreover, the metalens passes an incident light having an incident angle less than a cutoff angle and rejects an incident light having an incident angle greater than the cutoff angle. The metalens can be used a base unit for constructing a metalens array by tiling copies of the metalens into a 2D array of the metalens to achieve a significantly larger field-of-view. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/263268 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/00 (20130101) Original (OR) Class G02B 3/0006 (20130101) G02B 5/201 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119065 | Hilliard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seth Michael Hilliard (Yelm, Washington); Karen Mosoyan (Glendale, California); Andrei Rodin (Duarte, California) |
| ABSTRACT | Systems, methods, and computer readable storage mediums for performing multidimensional cytometry data analysis are described. The method includes filtering multidimensional cytometry data, based on a signal strength within each dimension of the plurality of dimensions, to select representative dimensions from the plurality of dimension, selecting an initial region within the representative dimensions of the multidimensional cytometry data. The initial region can include a bin with a maximum significance level. A significant region of the representative dimensions, presenting a response different from a reference response, can be determined by expanding the initial region to regions with a set significance. A display including the significant region of the representative dimensions of the multidimensional cytometry data can be generated. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/481940 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/283 (20190101) Original (OR) Class G06F 16/24573 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119263 | DU et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong DU (Lutherville-Timonium, Maryland); Kevin H. LEUNG (Baltimore, Maryland); Martin Gilbert POMPER (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/531928 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/045 (20230101) Original (OR) Class G06N 3/0985 (20230101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119597 | Madabhushi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Nathaniel Braman (Cleveland, Ohio); Kavya Ravichandran (Westlake, Ohio); Andrew Janowczyk (East Meadow, New York) |
| ABSTRACT | The present disclosure relates to a method that provides a pre-treatment image of a region of tissue to a deep learning model. The pre-treatment image includes at least one lesion. The deep learning model has been trained to generate a first prediction as to whether the region of tissue will respond to medical treatment. A set of radiomic features are extracted from the pre-treatment image and are provided to a machine learning model. The machine learning model has been trained to generate a second prediction as to whether the region of tissue will respond to the medical treatment based on the set of radiomic features. The deep learning model is controlled to generate the first prediction and the machine learning model is controlled to generate the second prediction. A classification of the region of tissue as a responder or non-responder is generated based on the first and second prediction. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545231 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/0014 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/454 (20220101) G06V 10/764 (20220101) G06V 10/809 (20220101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 40/00 (20190201) G16B 50/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120021 | Shendure et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Shendure (Seattle, Washington); Andrew Adey (Seattle, Washington); Joshua Burton (Seattle, Washington); Jacob Kitzman (Seattle, Washington); Maitreya J. Dunham (Seattle, Washington); Ivan Liachko (Seattle, Washington) |
| ABSTRACT | Computational methods used for large scale scaffolding of a genome assembly are provided. Such methods may include a step of applying a location clustering model to a test set of contigs to form two or more location cluster groups, each location cluster group comprising one or more location-clustered contigs; a step of applying an ordering model to each of the two or more location cluster groups to form an ordered set of one or more location-clustered contigs within each cluster group; and a step of applying an orienting model to each ordered set of one or more location-clustered contigs to assign a relative orientation to each of the location-clustered contigs within each location cluster group. In some aspects, the test set of contigs are generated from aligning a set of reads generated by a chromosome conformation analysis technique (e.g., Hi-C) with a draft assembly, a reference assembly, or both. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311775 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 30/20 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120023 | Naughton et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Brian Thomas Naughton (Mountain View, California); Colin Harvey (Mountain View, California); Ulrich Schlecht (Falkensee, Germany); Maureen Elizabeth Hillenmeyer (Palo Alto, California); Joe Horecka (Fremont, California) |
| ABSTRACT | Methods for identifying biosynthetic gene clusters that include genes for producing compounds that interact with specific target proteins are disclosed. Some methods relate to bioinformatics methods for identifying and/or prioritizing biosynthetic gene clusters. Related systems, components, and tools for the identification and expression of such gene clusters are also disclosed. |
| FILED | Friday, July 07, 2023 |
| APPL NO | 18/348930 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/79 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 10/00 (20190201) G16B 20/00 (20190201) Original (OR) Class G16B 25/00 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120032 | Mahajan et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinit Mahajan (Redwood City, California); Young Joo Sun (Redwood City, California); Gabriel Velez (Redwood City, California); Dylan Parsons (Redwood City, California) |
| ABSTRACT | A high-resolution crystallographic structure of the mutant human G267S calpain-5 protease core domain at 2.22 Å resolution is provided. The G267S mutation is associated with hyperactivity of calpain-5 and is linked to the inherited disease, neovascular inflammatory vitreoretinopathy. Methods of using the crystallographic structure in rational design of small molecule drugs that inhibit calpain-5 for treatment of retinal diseases and other diseases associated with calpain-5 hyperactivity are also provided. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 18/030046 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6472 (20130101) Enzymes C12Y 304/22 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/30 (20190201) Original (OR) Class G16C 20/50 (20190201) G16C 20/64 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240115187 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Quan Zhang (Winchester, Massachusetts); Gary Strangman (Boxford, Massachusetts) |
| ABSTRACT | A system and a method is provided for assessing motion of a biological tissue of a subject including one or more superficial biological layers and a targeted biological layer. A perturbation unit provide an optical perturbation to the one or more superficial biological layers. An optical signal generator transmits optical signals at one or more near-infrared wavelengths. An optical signal receiver acquires a set of optical signal data preceding, during, or following the optical perturbation at a first acquisition time relative to the optical perturbation. A signal processor determines, using the set of optical signal data, a set of optical characteristics and separates, using the set of optical characteristics, a target optical signal. The signal processor generates a report indicative of a movement of the targeted biological tissue within the subject. The movement of the targeted biological layer is calculated using the target optical signal. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538583 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/4064 (20130101) Original (OR) Class A61B 5/6814 (20130101) A61B 5/14553 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115556 | Islam et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cancer Research Technology Limited (London, United Kingdom); The Chancellor, Masters And Scholars Of The University Of Oxford (Oxford, United Kingdom); The Institute of Cancer Research: Royal Cancer Hospital (London, United Kingdom); University of Washington (Seattle, Washington); The United States Government represented by The Department Of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Md. Saiful Islam (Oxford, United Kingdom); Anthony Tumber (Oxford, United Kingdom); Christopher Schofield (Oxford, United Kingdom); Alec Paschalis (London, United Kingdom); Jonathan Welti (London, United Kingdom); Adam Sharp (London, United Kingdom); Johann de Bono (London, United Kingdom); Stephen Plymate (Seattle, Washington) |
| ABSTRACT | The invention relates to methods for treating prostate cancer by targeting the generation of splice variants of the androgen receptor. In one aspect, this can be achieved by targeting JMJD6 to reduce the production of androgen receptor splice variants. The invention finds particular use in the treatment of prostate cancer that is resistant to conventional androgen therapy. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 18/257801 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115557 | Choudhary et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Choudhary (Boston, Massachusetts); Donghyun Lim (Cambridge, Massachusetts); Qingxuan Zhou (Boston, Massachusetts); Kurt Cox (Cambridge, Massachusetts); Benjamin Law (Cambridge, Massachusetts); Miseon Lee (Cambridge, Massachusetts); Praveen Kokkonda (Boston, Massachusetts); Sreekanth Vedagopuram (Boston, Massachusetts) |
| ABSTRACT | The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in the demand for inhibitory anti-CRISPR molecules. Current small-molecule inhibitor discovery platforms are not generalizable to multiple nuclease classes, only target the initial step in the catalytic activity, and require high concentration of nuclease, resulting in inhibitors with suboptimal attributes, including poor potency. Herein, Applicants report a high-throughput discovery pipeline consisting of a FRET-based assay that is generalizable to contemporary and emerging nucleases, operates at low nuclease concentration, and targets all catalytic steps. Applicants applied this pipeline to identify BRD7586, a cell-permeable small-molecule inhibitor of SpCas9, that is 2-fold more potent than current inhibitors. Furthermore, unlike the reported inhibitors, BRD7586 enhanced SpCas9 specificity and its activity was independent of the genomic loci, DNA repair pathway, or mode of nuclease delivery. Overall, these studies describe a general pipeline to identify inhibitors of contemporary and emerging CRISPR-associated nucleases. Described herein are compositions and methods for inhibiting the activity of RNA-guided endonucleases, and methods for identifying such compositions. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/361352 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4439 (20130101) Original (OR) Class Enzymes C12Y 301/22001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115610 | BHATNAGAR et al. |
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| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Parijat BHATNAGAR (Belmont, California); Marvin A. SSEMADAALI (Menlo Park, California) |
| ABSTRACT | An example antigen test device comprises a genetically engineered diagnostic cell comprising an exogenous polynucleotide sequence including a receptor element that encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain that recognizes an antigen on a surface of a pathogen-infected cell from a sample or on a surface of a virus particle associated with a pathogen from the sample, an actuator element that encodes a transcription factor binding site, and an effector element that encodes a detectable reporter protein, wherein, in response to the antigen binding domain of the CAR binding to the antigen, the genetically engineered diagnostic cell is configured to activate and to synthesize the detectable reporter protein. |
| FILED | Tuesday, June 13, 2023 |
| APPL NO | 18/333778 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/2803 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115684 | McNeel et al. |
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| FUNDED BY |
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| APPLICANT(S) | Madison Vaccines Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Doug McNeel (Madison, Wisconsin); Richard Lesniewski (Madison, Wisconsin) |
| ABSTRACT | Provided herein is technology relating to cancer treatment and prevention and particularly, but not exclusively, to compositions and methods related to therapies for prostate cancer. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/492311 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/001163 (20180801) A61K 39/001193 (20180801) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/53 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/3069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116007 | Sirkar et al. |
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| FUNDED BY |
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| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institude of Technology (Newark, New Jersey) |
| INVENTOR(S) | Kamalesh Sirkar (Bridgewater, New Jersey); Yufeng Song (Newark, New Jersey) |
| ABSTRACT | A module for gas and/or vapor removal from a fluid stream is provided. The module includes at least one hollow fiber membrane including a first end and an opposing second end. The hollow fiber membrane includes a fiber wall defining an interior bore extending from the first end to the opposing second end and defining a passage for fluid flow through the hollow fiber membrane. The module includes a bed of metal organic framework (MOF) integrated into membrane pores of the fiber wall of the at least one hollow fiber membrane, into the hollow fiber membrane bore, and/or outside of the at least one hollow fiber membrane in an extracapillary space. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/377482 |
| CURRENT CPC | Separation B01D 15/10 (20130101) B01D 53/04 (20130101) B01D 53/229 (20130101) B01D 63/04 (20130101) B01D 69/02 (20130101) B01D 69/08 (20130101) B01D 69/147 (20130101) Original (OR) Class B01D 71/028 (20130101) B01D 2253/204 (20130101) B01D 2325/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116094 | Tour et al. |
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| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | James M. Tour (Houston, Texas); Bing Deng (Houston, Texas) |
| ABSTRACT | Method and system for soil remediation by flash Joule heating. A contaminated soil that includes organic pollutants and/or one or more metal pollutants can be mixed with carbon black or other conductive additive to form a mixture. The mixture then undergoes flash Joule heating to clean the soil (by the decomposing of the organic pollutants and/or removing of the one or more toxic metals, such as by vaporization). |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/263831 |
| CURRENT CPC | Reclamation of Contaminated Soil B09C 1/085 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116489 | Shukla et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oshkosh Defense, LLC (, None) |
| ASSIGNEE(S) | Oshkosh Defense, LLC (, None) |
| INVENTOR(S) | Deepak Shukla (Oshkosh, Wisconsin); Rongjun Zhang (Neenah, Wisconsin); Nader Nasr (Neenah, Wisconsin) |
| ABSTRACT | A vehicle is operable in three modes of operation. The vehicle includes a first electromagnetic device, a second electromagnetic device electrically coupled to the first electromagnetic device, and an engine coupled to the first electromagnetic device and configured to drive the first electromagnetic device to provide electrical energy. In each of the three modes of operation, whenever the engine drives the first electromagnetic device to provide the electrical energy, the first electromagnetic device operates without providing the electrical energy to an energy storage device. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491493 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 6/26 (20130101) B60K 6/34 (20130101) B60K 6/52 (20130101) B60K 6/365 (20130101) B60K 6/387 (20130101) B60K 6/445 (20130101) B60K 6/543 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/11 (20190201) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 10/02 (20130101) B60W 10/06 (20130101) B60W 10/08 (20130101) B60W 20/10 (20130101) Original (OR) Class B60W 2510/06 (20130101) B60W 2510/08 (20130101) B60W 2510/081 (20130101) B60W 2510/0604 (20130101) B60W 2510/0638 (20130101) B60W 2520/10 (20130101) B60W 2710/06 (20130101) B60W 2710/08 (20130101) B60W 2710/021 (20130101) B60W 2710/083 (20130101) B60W 2710/0644 (20130101) B60W 2710/0677 (20130101) Indexing Scheme Relating to Aspects Cross-cutting Vehicle Technology B60Y 2200/92 (20130101) B60Y 2300/42 (20130101) B60Y 2300/43 (20130101) B60Y 2300/60 (20130101) B60Y 2300/72 (20130101) B60Y 2400/72 (20130101) B60Y 2400/73 (20130101) Gearing F16H 1/28 (20130101) F16H 3/72 (20130101) F16H 3/727 (20130101) F16H 3/728 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/62 (20130101) Y02T 10/92 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 903/91 (20130101) Y10S 903/93 (20130101) Y10S 903/906 (20130101) Y10S 903/914 (20130101) Y10S 903/916 (20130101) Y10S 903/918 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116632 | Buckler et al. |
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| FUNDED BY |
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| APPLICANT(S) | Matthew Thomas Buckler (Fredericksburg, Virginia); Michael M. Canaday (King George, Virginia); Thomas Klebert Houck, Jr. (Woodford, Virginia); Gregory Noble Fish (King George, Virginia); William Michael McCoy (Green Cove Spring, Florida); Nathan Arnold Lambert (King George, Virginia); Timothy Gerald Burcham (Fredericksburg, Virginia); Xavier Anthony Quinn (Alexandria, Virginia); Douglas Lawrence Ramers (Blanchard, Idaho); Sabrina Hong-Yee Lau (Spotsylvania, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Matthew Thomas Buckler (Fredericksburg, Virginia); Michael M. Canaday (King George, Virginia); Thomas Klebert Houck, Jr. (Woodford, Virginia); Gregory Noble Fish (King George, Virginia); William Michael McCoy (Green Cove Spring, Florida); Nathan Arnold Lambert (King George, Virginia); Timothy Gerald Burcham (Fredericksburg, Virginia); Xavier Anthony Quinn (Alexandria, Virginia); Douglas Lawrence Ramers (Blanchard, Idaho); Sabrina Hong-Yee Lau (Spotsylvania, Virginia) |
| ABSTRACT | A recoil device is provided for a gun having a barrel with a breech. The device includes a breech nut, a brake assembly, a pneumatic spring and a counter-recoil buffer. The breech nut has first and second adjacent sides. The brake assembly includes a brake cylinder that mounts to the breech nut on the first side. The pneumatic spring mounts to the breech nut on the second side. The counter-recoil buffer attaches to the pneumatic spring. The brake cylinder and the pneumatic spring internally push fluids for recoil absorption and return in response to firing the gun. |
| FILED | Tuesday, June 20, 2023 |
| APPL NO | 18/211763 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 7/02 (20130101) Original (OR) Class Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 25/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116968 | Ridenour |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James August Ridenour (Arlington, Virginia) |
| ABSTRACT | Tunable thermochromic materials comprise a metal salt with a varying proportion of two different anions and an organic ligand. Partial substitution via doping during the initial synthesis with a macro-structurally similar (generating an isostructural material) yet chemically different anion creates a material with altered thermochromic properties. For example, in bromide-doped bis(N,N′-diethylethylenediamine)nickel(II)) tetrafluoroborate; both the tetrafluoroborate (BF4—) and bromide (Br—) derivatives are isostructural. Substitution of BF4— for Br— causes a decrease in the materials' thermochromic transition temperature by approximately 10° C. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/961585 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117096 | Zheng et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu Zheng (Stanford, California); Zhenan Bao (Stanford, California) |
| ABSTRACT | Aspects involve a stretchable composite film including a polymer material having at least a portion of the polymer material being densified through covalently-attached fluorination molecules. In certain specific examples, fluorinated molecules are covalently attached to a surface region, in the form of a layer or film (e.g., polymer semiconductor (PSC) film of a transistor substrate) to facilitate operational stability and/or to encapsulation performance (e.g., stretchability-related performance). In certain other specific examples, the surface region and a fluorinated layer are used in a cooperative configuration to provide stability in the PSC film in one or more harsh environments characterized by one or more of humid air, and immersion of the PSC film in a bio-based fluid. |
| FILED | Friday, July 14, 2023 |
| APPL NO | 18/221998 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 283/00 (20130101) Original (OR) Class Organic electric solid-state devices H10K 10/46 (20230201) H10K 85/113 (20230201) H10K 85/151 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117286 | Glaven et al. |
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| FUNDED BY |
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| APPLICANT(S) | US Department of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | US Department of the Navy (Arlington, Virginia); The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Sarah Glaven (Washington, District of Columbia); Elizabeth Onderko (Alexandria, Virginia); Andrew Maygar (Arlington, Virginia); Matthew Yates (Washington, District of Columbia) |
| ABSTRACT | Described herein are biofilm bioreactors for synthesis at the interface between two liquids, and methods of using such bioreactors for the biotransformation of feedstocks into chemical products. Also contemplated is the extraction of such products. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488446 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/12 (20130101) C12M 23/24 (20130101) C12M 23/44 (20130101) Original (OR) Class C12M 23/58 (20130101) C12M 25/10 (20130101) C12M 29/16 (20130101) C12M 41/28 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117303 | AMINI |
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| FUNDED BY |
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| APPLICANT(S) | Trailhead Biosystems Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nooshin AMINI (Cleveland, Ohio) |
| ABSTRACT | Methods for generating human midbrain immature neurons and mature dopaminergic neurons from neural progenitor cells are provided. The immature and mature midbrain neurons are obtained from neural progenitors such as committed midbrain neural stem cells (NSCs) and midbrain neural progenitor cells (midbrain NPCs), which themselves are generated from human pluripotent stem cells. The methods for generating midbrain immature and mature neurons use chemically-defined culture media that allow for generation of mature dopaminergic neurons in as little as 23 days. Culture media, isolated cell populations and kits are also provided. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/199415 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) Original (OR) Class C12N 2501/13 (20130101) C12N 2501/42 (20130101) C12N 2501/91 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2501/815 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117310 | NAIR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Smita NAIR (Durham, North Carolina); Adam SWARTZ (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes systems and methods for in vitro differentiation of human cross-presenting CD141+CLEC9A+ dendritic cells from mobilized peripheral blood CD34+ hematopoietic stem cells. The dendritic cells may further comprise an antigen or nucleic acid encoding an antigen. Methods of using the cells are also provided. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468526 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 39/4615 (20230501) A61K 2039/575 (20130101) A61K 2039/5154 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) Original (OR) Class C12N 2501/22 (20130101) C12N 2501/26 (20130101) C12N 2506/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117322 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | James M. Wilson (Philadelphia, Pennsylvania); Qiang Wang (Philadelphia, Pennsylvania); April Tepe (Laurel, Maryland); Kevin Turner (Newtown Square, Pennsylvania) |
| ABSTRACT | A recombinant adeno-associated virus (rAAV) vector comprising an AAVhu68 capsid produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in asparagine-glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAAV and uses thereof. Additionally, rAAV having an engineered AAV capsid comprising at least one subpopulation of vp1 or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vp1 numbering are provided. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/484856 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/761 (20130101) Peptides C07K 14/005 (20130101) C07K 16/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117364 | KIANI et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samira KIANI (Scottsdale, Arizona); Mo Reza EBRAHIMKHANI (Scottsdale, Arizona); Farzaneh MOGHADAM (Tempe, Arizona) |
| ABSTRACT | Provided herein are CRISPR-based synthetic repression systems as well as methods and compositions using the synthetic repression systems to treat septicemia, an adverse immune response in a subject and Waldenström macroglobulinemia. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535658 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) Peptides C07K 14/4703 (20130101) C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) C12N 2830/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117447 | DEDENT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Talis Biomedical Corporation (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea DEDENT (San Jose, California); Shuyuan MA (San Jose, California); Hedia MAAMAR (San Jose, California) |
| ABSTRACT | Disclosed herein are primers and probes related to the detection of Neisseria gonorrhoeae via nucleic acid amplification testing (NAAT), for example to amplify and determine the presence of N. gonorrhoeae nucleic acids present in test samples. Specifically the present disclosure describes primers and probes that bind to the small subunit rRNA (cytosine (967)-C(5))-methyltransferase or rsmB gene of N. gonorrhoeae for detection via loop mediated isothermal amplification (LAMP) and molecular beacon hybridization. |
| FILED | Thursday, April 06, 2023 |
| APPL NO | 18/296978 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) C07H 21/04 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6883 (20130101) C12Q 2600/16 (20130101) C12Q 2600/118 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117499 | Cox |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Stephen Charles Cox (San Diego, California) |
| ABSTRACT | A corrosion resistant bimetal includes a part and one or more sacrificial anodes. The part includes a metal component that is susceptible to corrosion. The sacrificial anodes consists of an attachment to the part through a metallic bond between the metal component and the sacrificial anode to form a crystalline solid that includes the sacrificial anode and the metal component of the part. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/492320 |
| CURRENT CPC | Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 13/16 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 428/12736 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117782 | Hundley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | X-Bow Launch Systems Inc. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Hundley (Albuquerque, New Mexico); Mark Kaufman (Auburn, California); Michael McPherson (Socorro, New Mexico) |
| ABSTRACT | A method of making a multi-grained fuel grain for a rocket is disclosed, the method comprising the steps of using at least one nozzle to extrude a first propellant in an additive manufacturing process, the first propellant comprising a multi-grained fuel grain, the multi-grained fuel grain forming the at least one void, the at least one void facilitating variation in internal ballistics, forming sensors, said sensors permitting continuous monitoring and continuous modification such that a user controls the ballistics profile of a rocket motor, forming an electrically-controlled second propellant in contact with and operatively coupled to the sensors; and wherein the additive manufacturing process uses at least at least one nozzle to extrude raw materials. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390025 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Jet-propulsion Plants F02K 9/10 (20130101) F02K 9/24 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/80 (20130101) F05D 2230/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117797 | KEIDAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael KEIDAR (Baltimore, Maryland); Anmol TAPLOO (Washington, District of Columbia); Li LIN (Arlington, Virginia) |
| ABSTRACT | A plasma thruster has a tunable electron source configured to provide electrons with controllable energy. An entry electrode and an exit electrode permit an air flow to pass from the entry electrode to the exit electrode. The entry electrode and exit electrode receive electrons from the tunable electron source. A controller selectively controls the entry and exit electrodes to accelerate positive and negative ions in the air. |
| FILED | Friday, June 16, 2023 |
| APPL NO | 18/336425 |
| CURRENT CPC | Producing a Reactive Propulsive Thrust, Not Otherwise Provided for F03H 1/0037 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 15/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118058 | BURGOA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ROBERT BURGOA (San Diego, California) |
| ABSTRACT | A counter-underwater vehicle apparatus and marker. Moreover, a counter-underwater vehicle apparatus comprising a plurality of entanglement lines; a box configured to contain the plurality of entanglement lines; a suction cup coupled to the box configured to attach the box to a surface of an underwater vehicle; a release mechanism coupled to the box configured to detach the box from a bite plate and release the plurality of entanglement lines; and the bite plate selectively coupled to the release mechanism. Additionally a marker configured to highlight the location of an underwater vehicle, a box configured to contain and release the marker, a suction cup coupled to the box configured to attach to the box a surface of an underwater vehicle, a release mechanism coupled to the box configured to detach the box from a bite plate and release the marker, and the bite plate selectively coupled to the release mechanism. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/938074 |
| CURRENT CPC | Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/28 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 11/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118061 | Galloway et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin C. Galloway (Nashville, Tennessee); Kelsay E. Neely (Nashville, Tennessee); Aimee J. Valles (Nashville, Tennessee); Robert J. Clark (Nashville, Tennessee); Jesse L. Frederick (Nashville, Tennessee) |
| ABSTRACT | Shaped charge devices, systems, and related methods of use. A housing sheet is configurable to form at least part of a shaped charge enclosure enclosing a shaped charge and biasing an explosion in a desired direction. The housing sheet can include one or more incisions in at least one surface thereof. The housing sheet can have at least one connection mechanism integrally formed therein, and the housing sheet can be configurable to form a plurality of sizes of shaped charge housing portions. The housing sheet can also provide for forming a plurality of dimensions of the shaped charge enclosure. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/316616 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 1/028 (20130101) Original (OR) Class F42B 1/036 (20130101) F42B 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118076 | Carrier et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Matthew J. Carrier (Covington, Louisiana); Hans E. Ngodock (Slidell, Louisiana); Josette P. Fabre (Slidell, Louisiana) |
| ABSTRACT | A method of determining ocean state. The method may include receiving, by a processing device, data associated with a prior ocean forecast state, and receiving, by the processing device, data associated with a first set of ocean temperature and salinity observations. The method may include receiving, by the processing device, data associated with a first set of ocean acoustic pressure observations. The method may include determining, by the processing device, a correction to the prior ocean forecast state based on a forward acoustic model, on an adjoint acoustic model, on the data associated with a first set of ocean temperature and ocean salinity observations, and on the data associated with a first set of ocean acoustic pressure observations, and generating, by the processing device, a current ocean state based on the determined correction. |
| FILED | Thursday, September 21, 2023 |
| APPL NO | 18/471664 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/002 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118129 | ZHOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qin ZHOU (Fremont, California); Alexander K. ZETTL (Kensington, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to an ultrasonic microphone and an ultrasonic acoustic radio. In one aspect a system includes a transmitter and a receiver. The receiver comprises a membrane. The membrane comprises a single layer or multiple layers of a two-dimensional material. The receiver is operable to receive sound waves in a frequency range, with the frequency range being the ultrasonic frequency range. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/534337 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 3/12 (20130101) G01H 11/06 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/104 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 1/08 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118137 | Mullins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Marshall Mullins (Bloomington, Indiana); Charles Upton (Jasper, Indiana); Tyler Fitzsimmons (Bloomington, Indiana); Joseph Morris (Bloomington, Indiana) |
| ABSTRACT | Provided is a gyroscope stabilized gimbal assembly for collecting and timestamping video data and laser measurement data. The assembly can be used on multiple platforms and provides an ISR video camera system and one or more laser measurement devices, including photodetectors, thermopiles, filters, and analog to digital converters. The components are mounted to a bracket that can be installed and removed from the assembly to collect/record measurement data from the devices interacting with the laser beam. A processor collects and records measurement data from the devices interacting with the laser beam and calculates optical power data, irradiance data, and wavelength data. A storage device stores a first set of data comprising video data from said camera system and a second set of data comprising optical power data, irradiance data, and wavelength data, wherein said first and second set of data are timestamped, separated, and not comingled. |
| FILED | Monday, May 15, 2023 |
| APPL NO | 18/197425 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/28 (20130101) G01J 3/0202 (20130101) Original (OR) Class G01J 5/12 (20130101) G01J 5/0205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118144 | Murray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Matthew Joseph Murray (Alexandria, Virginia); Joseph Brady Murray (Ellicott City, Maryland); Hannah Marie Ogden (Glen Burnie, Maryland); Brandon F. Redding (University Park, Maryland) |
| ABSTRACT | Methods providing distributed temperature and strain measurements are disclosed. Brillouin pump laser pulses having a Brillouin pump frequency are coupled into a first end of an optical fiber. Brillouin Stokes and Anti-Stokes probe laser beams are coupled into a second end of the fiber. The Stokes probe laser beam has a Stokes probe frequency. The Anti-Stokes probe laser beam has an Anti-Stokes probe frequency. The Stokes and Anti-Stokes probe frequencies and the pump frequency are included in a Brillouin frequency band. A train of Rayleigh seed pulses are coupled into the fiber. Each of the seed pulses of the train has a respective different frequency included in a Rayleigh frequency band. Frequencies of the Brillouin frequency band are coupled to a Brillouin detector, and Rayleigh backscatter signals are coupled to a Rayleigh detector. Brillouin and Rayleigh detector outputs are used to calculate the measurements. Related sensors are also disclosed. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/474855 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/35364 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/322 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118204 | Nag et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Okhil K. Nag (Brandywine, Maryland); Michael H. Stewart (Springfield, Virginia); Bethany Almeida (, None); James Delehanty (Washington, District of Columbia) |
| ABSTRACT | A semiconducting nanocrystal (quantum dot or QD) and ferric dithiocarbamate complex (QD-Fe(DTC)3) operate as a sensing system to detect nitric oxide (NO) in ambient conditions using fluorescence resonance energy transfer (FRET). The sensing system comprises two components: (1) an energy donor in the form of a dihydrolipoic acid (DHLA)-coated QD with strong fluorescence emission, and (2) an energy acceptor in the form of a ferric ion-dithiocarbamate complex (Fe(DTC)3) that binds onto the QD surface via carboxylate coordination. The ferric ion in the QD-Fe(DTC)3 complex acts a strong energy acceptor, resulting in weak fluorescence (FL) emission (“turn-off”) of the QD when excited using 405 nm light. In the presence of NO, ferric ion (3+) reduces to ferrous (2+), with decreased ability to accept energy from the QD, in turn appearing as increased FL emission from the QD (“turn-on”) as a sensing signal. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/374796 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/025 (20130101) C09K 11/883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) Original (OR) Class G01N 33/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118315 | NIELSON |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nielson Scientific, LLC (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory NIELSON (Lehi, Utah) |
| ABSTRACT | A probe card comprises a support element that has a first side and a second side opposite the first side. A plurality of probe tips extend outward from the first side of the support element, the probe tips configured to make contact with components of a device-under-test (DUT). A plurality of vias extend through the support element from the first side to the second side, each of the vias connected to a respective probe tip in the plurality of probe tips. A plurality of conductive traces are formed on the support element, and each of the traces is connected to a respective via in the plurality of vias, wherein electrical signals can be provided to or received from the probe tips by way of the conductive traces. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 18/552400 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 1/07342 (20130101) Original (OR) Class G01R 1/07378 (20130101) G01R 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118372 | Loehrlein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Ryan Loehrlein (Bloomington, Indiana); Timothy Ringwald (Loogootee, Indiana); Kimberly Gold (Nashville, Tennessee); Jeffrey A. Miller (Bloomington, Indiana) |
| ABSTRACT | Disclosed are methods and apparatus for recording time, latitude, longitude, frequency, and amplitude data to ascertain information about the radio frequency (RF) environment (e.g., RF emitter locations), where the apparatus is also easily transportable. The location determination method using this simple hardware solution may occur in two processes or phases: (1) a data collection phase; and (2) a data processing phase, although these two phases may also be combined in time for a real time solution. During the data collection phase, a user may select a desired frequency range and step size for analysis. A software defined radio (SDR) sweeps through the desired frequencies and records the amplitude associated with each frequency. Each of the recorded points are stamped with their time and geolocation (i.e., latitude and longitude coordinates) and processed using amplitude measurements to ascertain the locations of unknown emitters. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/227728 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/02524 (20200501) Original (OR) Class G01S 5/02527 (20200501) Image Data Processing or Generation, in General G06T 11/206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118554 | Aieta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Francesco Aieta (Sunnyvale, California); Mikhail Kats (Madison, Wisconsin); Patrice Genevet (Valbonne, France); Federico Capasso (Cambridge, Massachusetts); Mohammadreza Khorasaninejad (Belmont, Massachusetts) |
| ABSTRACT | Multi-wavelength light is directed to an optic including a substrate and metasurface optical components deposited on a surface of the substrate. The metasurface optical components comprise a pattern of silicon dielectric resonators with nonperiodic gap distances between adjacent dielectric resonators. Incident light directed to the metasurface optical components is scattered and phase-shifted by the configuration of the gap distances and the widths and thicknesses of the dielectric resonators. Each dielectric resonator has a rectangular cross-section such that a first phase shift is imparted for a transverse-electric (TE) component of the incident light and a second phase shift is imparted for a transverse-magnetic (TM) component of the incident light. |
| FILED | Tuesday, July 11, 2023 |
| APPL NO | 18/220764 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/008 (20130101) G02B 5/203 (20130101) G02B 5/1809 (20130101) G02B 27/4211 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 15/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119015 | Sharma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shruti Sharma (Beaverton, Oregon); Robert Pawlowski (Beaverton, Oregon) |
| ABSTRACT | Systems, apparatuses and methods may provide for technology that detects a condition in which a plurality of atomic instructions target a common address and different bit positions in a mask, generates a combined read-lock request for the plurality of atomic instructions in response to the condition, and sends the combined read-lock request to a lock buffer coupled to a memory device associated with the common address. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458462 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/526 (20130101) G06F 13/1673 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119337 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Qian XU (Chicago, Illinois); LIANG JIANG (Chicago, Illinois) |
| ABSTRACT | The present disclosure describes various methods, systems, and storage medium for engineering fast bias-preserving gates on stabilized cat qubits. One method for performing a quantum operation on a qubit using a noise-bias-preserving (NBP) quantum gate includes obtaining and stabilizing the qubit; determining a type of the NBP quantum gate associated with the quantum operation, according to type of the NBP quantum gate, the quantum operation on the qubit to obtain a modified qubit, the quantum operation comprising a base gate drive and a counterdiabatic (CD) control drive. Another method for stabilizing a qubit for quantum storage includes obtaining a qubit; in response to the qubit being in an idle state, applying a two-photon dissipation operation on the qubit to stabilize the qubit, the two-photon dissipation operation corresponding to a two-photon drive. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 18/272410 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) G06N 10/70 (20220101) Original (OR) Class Pulse Technique H03K 17/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119597 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Nathaniel Braman (Cleveland, Ohio); Kavya Ravichandran (Westlake, Ohio); Andrew Janowczyk (East Meadow, New York) |
| ABSTRACT | The present disclosure relates to a method that provides a pre-treatment image of a region of tissue to a deep learning model. The pre-treatment image includes at least one lesion. The deep learning model has been trained to generate a first prediction as to whether the region of tissue will respond to medical treatment. A set of radiomic features are extracted from the pre-treatment image and are provided to a machine learning model. The machine learning model has been trained to generate a second prediction as to whether the region of tissue will respond to the medical treatment based on the set of radiomic features. The deep learning model is controlled to generate the first prediction and the machine learning model is controlled to generate the second prediction. A classification of the region of tissue as a responder or non-responder is generated based on the first and second prediction. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545231 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/0014 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/454 (20220101) G06V 10/764 (20220101) G06V 10/809 (20220101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 40/00 (20190201) G16B 50/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119671 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shichen LIU (Los Angeles, California); Yunxuan CAI (Los Angeles, California); Yajie ZHAO (Los Angeles, California); Bipin KISHORE (Los Angeles, California) |
| ABSTRACT | Methods, mediums, and systems for constructing a 3D face model, including Deep Iterative Face Fitting (DIFF) and Recurrent Feature Alignment (ReFA). A processor provides a reference—containing a 3D mesh representing a median face, vertex positions, or surface points—as a template and UV texture mapping pointing the 3D mesh to a 2D UV space; receives input image(s) of a face and extracts geometry/texture features in an image space; extracts features in a UV space; iteratively produces a feature map via visual semantic correlation between UV and image spaces and regress geometry updates, predicting texture maps and comparing features, and inputs the map to an RNN-based neural optimizer of Gated Recurrent Units (GRU) to determine a hidden state. A head pose and/or updated 3D mesh/UV-space position map is output, each pixel in the UV-space map storing a coordinate of a corresponding point in a canonical space of the 3D mesh. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472826 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/40 (20130101) G06T 7/60 (20130101) G06T 7/70 (20170101) G06T 17/20 (20130101) Original (OR) Class G06T 2207/10024 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119734 | Aelmore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary o the Navy (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| INVENTOR(S) | Stephanie Lilith Aelmore (San Diego, California); Richard Christopher Ordoñez (San Diego, California) |
| ABSTRACT | The invention is a system and method for efficient filtering, clustering, tracking and persistent motion detection for event cameras. More particularly, embodiments of the present invention combine compatible asynchronous event filtering and clustering techniques in a computationally efficient way to identify and track objects in the field of view that exhibit persistent motion characteristic of marine vessels, cars, aircraft, and other vehicles while ignoring dynamic background elements that move in a more erratic fashion. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 18/045608 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/20 (20130101) G06T 2207/20024 (20130101) Image or Video Recognition or Understanding G06V 10/30 (20220101) G06V 10/762 (20220101) G06V 20/44 (20220101) Original (OR) Class G06V 2201/07 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119746 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Teng-Chieh Liu (Seattle, Washington); Weisi Xie (Seattle, Washington); Nicholas P. Reder (Seattle, Washington) |
| ABSTRACT | Apparatuses, systems, and methods for synthetic 3D digital microscopy image sets. A microscope captures a depth stack of a sample using a first labelling technique. A trained machine learning model generates a synthetic depth stack of images based on the imaged depth stack. The synthetic depth stack mimics the appearance of a second labelling technique, which is targeted to a tissue structure of interest. A segmentation mask is generated based on the synthetic depth stack. The machine learning model may be trained on depth stacks of samples prepared with both the first and the second labelling techniques. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 18/271203 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4038 (20130101) G06T 7/11 (20170101) G06T 11/00 (20130101) Image or Video Recognition or Understanding G06V 20/70 (20220101) G06V 20/695 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120125 | HUANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shilin HUANG (Durham, North Carolina); Ye WANG (Durham, North Carolina); Kenneth BROWN (Durham, North Carolina) |
| ABSTRACT | Technologies for suppressing effects of crosstalk in a quantum circuit of a quantum computing system are disclosed. A pair of target qubits on which to perform a quantum gate operation is selected. The quantum gate operation is performed. A rotation is induced on the target qubits such that crosstalk between any of the target qubits and any of the neighboring qubits in the quantum circuit is canceled out. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/107942 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120201 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Travis J. Anderson (Alexandria, Virginia); Mona A. Ebrish (Nashville, Tennessee); Alan G. Jacobs (Rockville, Maryland); Karl D. Hobart (Alexandria, Virginia); Francis J. Kub (Arnold, Maryland) |
| ABSTRACT | A technique for selective-area diffusion doping of III-N epitaxial material layers and for fabricating power device structures utilizing this technique. Dopant species such as Mg are introduced into the III-N material layer and are diffused into the III-N material by annealing under stable or metastable conditions. The dopant species can be introduced via deposition of a metal or alloy layer containing such species using sputtering, e-beam evaporation or other technique known to those skilled in the art. The dopant material layer is capped with a thermally stable layer to prevent decomposition and out-diffusion, and then is annealed under stable or metastable conditions to diffuse the dopant into the III-N material GaN without decomposing the surface. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/193862 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/2258 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120506 | TOUR et al. |
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| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | James Mitchell TOUR (Houston, Texas); Weiyin CHEN (Houston, Texas); Duy X. LUONG (Houston, Texas); Carter KITTRELL (Houston, Texas) |
| ABSTRACT | Method and system for flash recycling of batteries, including lithium-ion batteries, other metal (sodium, potassium, zinc, magnesium, and aluminum)-ion batteries, metal batteries, batteries having all metal oxide cathodes, and batteries having graphite-containing anodes. The method and system include a solvent-free and water-free flash Joule heating (FJH) method performed upon a mixture that includes materials from the batteries done in millisecond for recycling the materials. In some embodiments, the FJH method is combined with magnetic separation to recover lithium, cobalt, nickel, and manganese with high yields up to 98%. In some embodiments, the FJH method is followed by rinsing with dilute acid, such a 0.01 M HCl. In other embodiments, the FJH method is utilized to purify the graphite in the battery, such as for use in the anode of the battery. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 18/264646 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 6/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120532 | ANGELL et al. |
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| FUNDED BY |
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| APPLICANT(S) | Charles Austen ANGELL (, None); Iolanda Santana KLEIN (Tempe, Arizona); Telpriore Greg TUCKER (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles Austen ANGELL (, None); Iolanda Santana KLEIN (Tempe, Arizona); Telpriore Greg TUCKER (Phoenix, Arizona) |
| ABSTRACT | A solid electrolyte represented by general formula LiySiRx(MO4), where x is an integer from 1 to 3 inclusive, y=4−x, each R present is independently C1-C3 alkyl or C1-C3 alkoxy, and M is sulfur, selenium, or tellurium. Methods of making the solid electrolyte include combining a phenylsilane and a first acid to yield mixture including benzene and a second acid, and combining at least one of an alkali halide, and alkali amide, and an alkali alkoxide with the second acid to yield a product d represented by general formula LiySiRx(MO4)y. The second acid may be in the form of a liquid or a solid. The phenylsilane includes at least one C1-C3 alkyl substituent or at least one C1-C3 alkoxy substituent, and the first acid includes at least one of sulfuric acid, selenic acid, and telluric acid. |
| FILED | Wednesday, June 07, 2023 |
| APPL NO | 18/330948 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/025 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0564 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120776 | Rodenbeck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Rodenbeck (Washington, District of Columbia); James Park (Washington, District of Columbia); Brian Tierney (Washington, District of Columbia); Mark Parent (Washington, District of Columbia); Christopher Depuma (Washington, District of Columbia) |
| ABSTRACT | Systems and methods are provided for power beaming that increase power density at the target location by exploiting scattering from terrain. The disclosed systems and methods further provide a variable focus feature allowing the beam power to be concentrated at specified standoff distances from the transmitter and increase the radio frequency (RF) power handling of the receiver using an overvoltage protection circuit in the DC load. |
| FILED | Saturday, September 30, 2023 |
| APPL NO | 18/375505 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/20 (20160201) Original (OR) Class H02J 50/90 (20160201) Transmission H04B 7/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240115987 | JEONG-POTTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Chae JEONG-POTTER (Valley Stream, New York); Martha ARELLANO-TREVINO (Denver, Colorado); Robert J. FARRAUTO (Princeton, New Jersey) |
| ABSTRACT | A dual function material is provided that captures carbon dioxide from ambient air, i.e., direct air capture, and converts the CO2 to a desired product such as methane. The material includes a high surface area carrier such as Al2O3 upon which catalysts and alkaline adsorbents are positioned proximate each other. In the presence of reactive gas such as hydrogen, the catalysts reduce the adjacent adsorbents to generate additional active sites and enhance the amount of CO2 captured by the material. Once the material becomes saturated with CO2, hydrogen is reintroduced to reduce the catalyst, such as ruthenium, at which time the adsorbed CO2 can migrate from the adsorbent to the catalyst for catalytic conversion to methane. The materials can be employed in isothermal, cyclic reactor systems where target species are bound and then desorbed to reactivate the material, e.g., bind more target species for desorption and/or conversion to additional product. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/526068 |
| CURRENT CPC | Separation B01D 53/04 (20130101) Original (OR) Class B01D 2253/1124 (20130101) B01D 2255/1026 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/041 (20130101) B01J 20/3078 (20130101) B01J 23/462 (20130101) B01J 37/08 (20130101) Acyclic or Carbocyclic Compounds C07C 1/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115989 | Green et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Green (Phoenix, Arizona); Klaus Lackner (Longmont, Colorado) |
| ABSTRACT | A continuous CO2 capture system, method, and device are disclosed. The device includes a CO2 pump membrane including a moisture-swing material, and a cavity having a first fluid. The CO2 pump membrane separates the first fluid from a second fluid, the fluids creating a water concentration gradient across the membrane and transport of water through the membrane. The water concentration gradient creates a carbon concentration gradient across the membrane that decreases moving from outside the cavity to inside the cavity. As water is continuously transported from the first fluid to the second fluid through the CO2 pump membrane because of the water concentration gradient, carbon dioxide is continuously captured from the second fluid by the moisture-swing material of the CO2 pump membrane and continuously pumped along the carbon concentration gradient across the CO2 pump membrane and into the first fluid within the cavity. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 18/263691 |
| CURRENT CPC | Separation B01D 53/228 (20130101) Original (OR) Class B01D 2053/221 (20130101) B01D 2257/504 (20130101) B01D 2311/26 (20130101) B01D 2313/28 (20130101) B01D 2315/10 (20130101) B01D 2325/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116006 | Linic et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suljo Linic (Ann Arbor, Michigan); James Wortman (Ann Arbor, Michigan); Rawan Almallahi (Ann Arbor, Michigan) |
| ABSTRACT | A catalyst system for propane dehydrogenation includes a hollow fiber members packed with a Pt1Sn1/SiO2 catalyst. The hollow fiber membrane includes a separation layer coated on an interior surface of a support tube. The separation layer selectively removes H2 generated during the propane dehydrogenation reaction. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/376332 |
| CURRENT CPC | Separation B01D 53/22 (20130101) B01D 69/08 (20130101) B01D 69/145 (20130101) Original (OR) Class B01D 71/025 (20130101) B01D 2257/108 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/08 (20130101) B01J 23/626 (20130101) B01J 35/0013 (20130101) B01J 35/065 (20130101) B01J 35/1061 (20130101) B01J 37/0201 (20130101) Acyclic or Carbocyclic Compounds C07C 5/48 (20130101) C07C 2523/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116110 | Barr et al. |
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| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| INVENTOR(S) | Christian Gentry Miles Barr (Kansas City, Missouri); Timothy Prost (Fremont, California) |
| ABSTRACT | A micro-alloyed copper powder was produced using gas atomization reaction synthesis, with the alloy preferably comprising Cu-0.3Zr-0.15Ag wt. %. The novel copper alloy improves the manufacturability of copper in powder bed fusion manufacturing processes by minimizing or avoiding the prior art problems associated with oxidation of the copper precursor used in additive manufacturing. Advantageously, the provided copper alloy powder maintains the high electrical conductivity of copper while addressing the prior art oxidation issue. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066843 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/16 (20220101) B22F 1/052 (20220101) B22F 9/08 (20130101) B22F 10/28 (20210101) Original (OR) Class B22F 2202/11 (20130101) B22F 2301/10 (20130101) B22F 2303/01 (20130101) B22F 2304/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116375 | Asa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erdem Asa (Oak Ridge, Tennessee); Veda Prakash Galigekere (Oak Ridge, Tennessee); Omer C. Onar (Oak Ridge, Tennessee); Burak Ozpineci (Oak Ridge, Tennessee); Jason L. Pries (Oak Ridge, Tennessee); Gui-Jia Su (Oak Ridge, Tennessee) |
| ABSTRACT | A method for wirelessly or conductively (non-wireless) providing AC or DC power in AC or DC load applications and bidirectional applications. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/235961 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/60 (20190201) B60L 53/122 (20190201) Original (OR) Class B60L 2210/20 (20130101) B60L 2210/30 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0047 (20130101) H02J 50/12 (20160201) H02J 50/80 (20160201) H02J 2310/48 (20200101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 5/293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116653 | Cooley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lance D. Cooley (Tallahassee, Florida); Christian M. Hubicki (Tallahassee, Florida) |
| ABSTRACT | Example coil guns and methods of using coil guns are described herein. An example coil gun includes a first pancake module; a second pancake module, where the first pancake module and the second pancake module are each formed of a winding with an inner superconducting material layer and an outer ordinary conductor layer, where the first pancake module and the second pancake module are physically and/or inductively coupled to propagate a quench of a superconducting state of the first pancake module to the second pancake module. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992588 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/002 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/02 (20130101) H01F 6/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117115 | Coates et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Brooks Abel (Ithaca, New York); Rachel Snyder (Ithaca, New York); Holley Grace Hester (Ithaca, New York) |
| ABSTRACT | Poly(cyclic acetal)s, methods of making same, and uses of same. The poly(cyclic acetal)s may have a number average molecular weight (Mn) of 10 to 3000 kiloDaltons (kDa) and over 50% of the chain ends may exclude hydroxyl groups. The poly(cyclic acetal) may be a homopolymer or copolymer(s) of poly(1,3-dioxolane) (PDXL). The poly(cyclic acetal)s may have one or more or all of: a thermal stability (Td,5%) of 337° C. to 392° C.; a thermal stability of (Td.50%) of 377° C. to 462° C.; or an Arrhenius activation energy (Ea) of 85.0 kJ/mol with 2 mol % of strong acid (e.g., pKa less than or equal to 4). Methods of polymerizing poly(cyclic acetal)s may comprise reacting cyclic acetal monomers with either Lewis acid catalysts and haloalkyl ether initiators or organic cation salt catalyst(s) and proton traps. Methods of chemically recycling poly(cyclic acetal)s into cyclic acetals may react poly(cyclic acetal)s with strong acids. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 18/262509 |
| CURRENT CPC | Heterocyclic Compounds C07D 317/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/16 (20130101) Original (OR) Class C08G 65/266 (20130101) C08G 2650/22 (20130101) C08G 2650/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117221 | Kryger et al. |
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| FUNDED BY |
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| APPLICANT(S) | 3M INNOVATIVE PROPERTIES COMPANY (St. Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew J. Kryger (Hudson, Wisconsin); Chase M. O'Brien (Roseville, Minnesota); Dennis C. Ngo (Woodbury, Minnesota); Eric R. Amann (St. Paul, Minnesota) |
| ABSTRACT | Methods of bonding a male element and a female element, the method including applying an adhesive composition to at least the male element, the male element including a first metal; inserting at least a portion of the male element into the female element thereby forming an external interface between the male element and the female element, the female element including a second metal; and curing the adhesive composition to form an adhesive bond between the male element and the female element, wherein the first metal and the second metal are not the same, wherein the external interface of the male element and female element is covered by the cured adhesive composition and the adhesive composition covering the external interface of the male element and female element limits corrosion of at least a portion of the male element, the female element, or both. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 18/257312 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 5/00 (20130101) Original (OR) Class C09J 11/04 (20130101) C09J 163/00 (20130101) C09J 2463/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117246 | Stracuzzi et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| INVENTOR(S) | Luis Stand Stracuzzi (Knoxville, Tennessee); Daniel Joseph Rutstrom (Knoxville, Tennessee); Mariya Zhuravleva (Knoxville, Tennessee); Charles L. Melcher (Oak Ridge, Tennessee) |
| ABSTRACT | Doped halide scintillator materials of the formulas A2B1-iX4:Di, AB1-iX2:Di, A1-iX:Di, and A3B1-iX5:Di, wherein A is one or more monovalent cations (e.g., Tl, In, Li, Na, K, Rb, or Cs); B is one or more divalent cations (e.g., Be, Mg, Ca, Sr, Ba, Zn, Cd, and Hg), X is one or more halide, and D is one or more transition or post-transition metal dopant ions (e.g., Zn, Cd, Hg, Cu, Mn, and Ga) are described. Also described are non-doped halide scintillator materials of the formula A3BX5, related radiation detectors, methods of detecting high energy radiation, and methods of preparing the scintillator materials. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/369468 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/626 (20130101) Original (OR) Class Measurement of Nuclear or X-radiation G01T 1/2006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117392 | NANGLE et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Shannon Noel NANGLE (Cambridge, Massachusetts); Marika ZIESACK (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to engineered chemoautotrophic bacteria and methods of producing triacylglycerides. Also described herein are systems or bioreactors comprising said engineered bacteria. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 18/274757 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 9/16 (20130101) C12N 9/1029 (20130101) C12N 9/1205 (20130101) C12N 2500/05 (20130101) C12N 2500/34 (20130101) C12N 2500/35 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6458 (20220101) Original (OR) Class Enzymes C12Y 203/0102 (20130101) C12Y 203/01015 (20130101) C12Y 207/01107 (20130101) C12Y 301/03004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117505 | Trembly |
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| FUNDED BY |
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| APPLICANT(S) | Ohio University (Athens, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Patrick Trembly (Athens, Ohio) |
| ABSTRACT | An apparatus for converting carbon dioxide and natural gas liquids into other chemicals and/or fuels, comprising at least one electrochemical cell, wherein the electrochemical cell reduces the endothermic load associated with electrochemical CO2 reduction, and a method for converting carbon dioxide and natural gas liquids into carbon monoxide and other chemicals and/or fuels, comprising converting CO2 into CO and converting C2H6 into C2H4 at a temperature in the range of 650° C.-750° C. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/536930 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) Original (OR) Class C25B 9/19 (20210101) C25B 9/70 (20210101) C25B 15/021 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117507 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongguo Li (Los Alamos, New Mexico); Yu Seung Kim (Los Alamos, New Mexico); Albert Sung Soo Lee (Los Alamos, New Mexico) |
| ABSTRACT | Water electrolysis systems that operate at intermediate temperature (i.e., between about 100° C. and about 300° C.) are described. At least some aspects of the present disclosure relate to proton exchange membrane steam electrolysis (PEMSE) systems including a polymer electrolyte comprising at least one phosphorus atom. In at some examples, the polymer electrolyte my comprise phosphonic acid. |
| FILED | Friday, October 27, 2023 |
| APPL NO | 18/384737 |
| CURRENT CPC | Separation B01D 67/00931 (20220801) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 39/04 (20130101) B01J 39/20 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 9/23 (20210101) Original (OR) Class C25B 9/73 (20210101) C25B 11/04 (20130101) C25B 13/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117521 | Rand et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Barry Rand (Princeton, New Jersey); Jordan Dull (Saint Anthony, Minnesota) |
| ABSTRACT | Disclosed are criteria for a lattice matched, multilayer, organic crystal heterostructure. Current organic devices (e.g., photovoltaics, light emitting diodes, or transistors) rely on amorphous material despite superior charge transport properties of crystalline organic semiconductors. Achieving a fully crystalline device architecture requires growth of a molecular crystal atop a different one, or heteroepitaxy, and is particularly relevant in organic semiconductor devices that demand multiple layers of different molecules. This challenge is complicated when attempting to stack highly ordered layers needed for crystalline devices because strategies are needed to ensure that each layer grows crystalline. It is shown herein that lattice matching alone is not sufficient for successful organic heteroepitaxy deposited via physical vapor deposition. The process disclosed herein includes an additional criterion in which the lattice matched plane of the adlayer must also be the crystal face with the lowest surface energy. Application of this process leads to a full crystalline multilayer system in which there is perfect registry between the template layer and adlayer. Not only does this allow for the study of highly ordered interfaces, but it also opens the door to entirely crystalline device architectures, likely improving the efficiency over their amorphous counterparts. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/374765 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/002 (20130101) C30B 23/025 (20130101) Original (OR) Class C30B 29/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117803 | Sames et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cinco Research Corporation (Elizabethton, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Sames (Johnson City, Tennessee); Amos Manneschmidt (Knoxville, Tennessee) |
| ABSTRACT | A reciprocating pump with a reservoir for collecting and controlling a working fluid level without the use of piston seals. A method of collecting and controlling a working fluid level in a reciprocating pump which has no piston seals. |
| FILED | Wednesday, May 24, 2023 |
| APPL NO | 18/322791 |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 19/22 (20130101) F04B 23/02 (20130101) F04B 49/03 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118001 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongbin Ma (Columbia, Missouri); Ramy Abdelhady (Columbia, Missouri) |
| ABSTRACT | A heat pump system and method of use are disclosed for cooling or heating utilizing a refrigerant that includes a compressor, an ejector in fluid communication with an output of the compressor, a condenser in fluid communication with an output of the ejector, a throttling valve in fluid communication with an output of the condenser. An evaporator having an input in fluid communication with an output of the throttling valve and an output in fluid communication with an input of the ejector and an input of the compressor. There is also disclosed for data centers, a combination evaporator-OHPs and the second plurality of combination evaporator-ejector OHPs for cooling a plurality of servers where the first plurality of combination evaporator-OHPs and the second plurality of combination evaporator-ejector OHPs each include an adjacent wicking structure that is adjacent to a vapor channel and a liquid channel. |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/467409 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 1/08 (20130101) Original (OR) Class F25B 5/02 (20130101) F25B 41/22 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118004 | Alahyari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abbas A. Alahyari (Glastonbury, Connecticut); Parag M. Kshirsagar (South Windsor, Connecticut) |
| ABSTRACT | A cryocooler device including a cryocooler including an input and an output, the input forming a cooling path, and a first stage that cools a working fluid in the cooling path. At least one thermal energy storage device selectively connectable to the cooling path and the cooling loop, wherein in a first operational mode of the cryocooler device where the at least one thermal energy storage device is connected to the cooling loop where the heat to be removed at the input exceeds a cooling capacity of the cryocooler device, and a second operational mode where the at least one thermal energy storage device is connected to the cooling path where the heat to be removed is less than the cooling capacity of the cryocooler and the heat is removed from the at least one thermal energy storage device. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/962048 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 33/08 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 9/10 (20130101) Original (OR) Class F25B 2400/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118038 | WARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick A. WARD (Aiken, South Carolina); Simona H. MURPH (Augusta, South Carolina); Henry T. SESSIONS, JR. (Aiken, South Carolina) |
| ABSTRACT | Disclosed are thermochemical energy storage materials that exhibit high enthalpy of reaction for an exothermic hydrogenation reaction at high temperature reaction conditions. Disclosed materials include titanium-aluminum-vanadium based alloys that can undergo high temperature reversible hydrogenation/dehydrogenation reactions. The materials include aluminum and vanadium in conjunction with titanium in amounts designed to encourage the high enthalpy of reaction and are substantially free of materials that would lower the enthalpy of reaction. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/960520 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/16 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118129 | ZHOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qin ZHOU (Fremont, California); Alexander K. ZETTL (Kensington, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to an ultrasonic microphone and an ultrasonic acoustic radio. In one aspect a system includes a transmitter and a receiver. The receiver comprises a membrane. The membrane comprises a single layer or multiple layers of a two-dimensional material. The receiver is operable to receive sound waves in a frequency range, with the frequency range being the ultrasonic frequency range. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/534337 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 3/12 (20130101) G01H 11/06 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/104 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 1/08 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118177 | Montgomery et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosemary A. Montgomery (Oak Ridge, Tennessee); Meng-Dawn Cheng (Oak Ridge, Tennessee); Yadukrishnan Sasikumar (Oak Ridge, Tennessee); Bruce B. Bevard (Oak Ridge, Tennessee) |
| ABSTRACT | A system for sampling aerosols, for purpose of predictive analyses, from fractured test specimens is provided. The system includes a test enclosure, a load apparatus, and an aerosol sampling pack in fluid communication with the test enclosure. The test enclosure is sized to partially or completely receive the test specimen therein, and the load apparatus is configured to impart a mechanical load (e.g., tension, bending, torsion, shear forces, or compression) on the test specimen. The aerosol sampling pack receives solid aerosols that are generated upon fracture of the test specimen. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469419 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2202 (20130101) Original (OR) Class G01N 1/2211 (20130101) G01N 2001/2223 (20130101) G01N 2203/0019 (20130101) G01N 2203/0021 (20130101) G01N 2203/0023 (20130101) G01N 2203/0025 (20130101) Nuclear Reactors G21C 17/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118214 | Riddle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Catherine Riddle (Idaho Falls, Idaho); Rick Demmer (Idaho Falls, Idaho) |
| ABSTRACT | A method for rapid detection of actinides including the steps of having a support including a colorimetric complexation, placing the support in communication with a sample through urinalysis, and receiving a visual indicator from the colorimetric complexation. The sample having an unknown concentration of at least one actinide within it. The colorimetric complexation is configured to activate when contacted by a threshold concentration of an actinide. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541620 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) Original (OR) Class G01N 21/8803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118411 | Sheen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | David M. Sheen (Richland, Washington); Richard Trevor Clark (Richland, Washington) |
| ABSTRACT | Imaging systems and associated methods are described. According to one aspect, an imaging system includes an antenna array having transmit and receive antennas, the transmit antennas emit electromagnetic energy from a plurality of different positions about a target imaging volume and the receive antennas receive reflections of the electromagnetic energy at the different positions, a transceiver configured to control the emission of the electromagnetic energy and to generate radar data that is indicative of the reflections of the electromagnetic energy received via the receive antennas; and processing circuitry configured to focus the radar data to provide first focused data in a first dimension, to focus the radar data in a second dimension to provide second focused data, and use the second focused data to focus the radar data in a third dimension to provide third focused data comprising an image of the target imaging volume. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959890 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/06 (20130101) G01S 7/043 (20130101) G01S 13/887 (20130101) Original (OR) Class G01S 13/9019 (20190501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118537 | DONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The MITRE Corporation (McLean, Virginia); Sandia National Laboratories (Albuquerque, New Mexico); MIT - Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia); Sandia National Laboratories (Albuquerque, New Mexico); MIT - Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Mark DONG (Somerville, Massachusetts); Gerald Neal GILBERT (Princeton, New Jersey); Matthew Scott EICHENFIELD (Albuquerque, New Mexico); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | Provided herein is a photonic integrated circuit and methods for controlling a photonic integrated circuit that can utilize the resonant frequency of one or more components of the photonic integrated circuit to enhance the response of the circuit. At least one component of the photonic integrated circuit can be driven by an electrical signal whose frequency is substantially equal to the mechanical resonance frequency of the component such that the response of the optical component is increased. The component of the photonic integrated circuit can include a phase shifter that can impart a phase shift on a received optical signal. By driving the phase shifter with an electrical signal that is equal to the mechanical resonance frequency of the optical phase shifter, less power can be required to impart a desired phase shift on a received optical signal. The optical components can be implemented using piezoelectric cantilevers. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/480981 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 26/103 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119327 | WU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaodi WU (Brookline, Massachusetts); Yuxiang PENG (Greenbelt, Maryland); Jacob YOUNG (Riverdale, Maryland) |
| ABSTRACT | Examples of the present disclosure provide systems and methods for performing quantum simulation. For example, such systems and methods may perform quantum simulation, at least in part, by obtaining a Hamiltonian equation and a selection of a target quantum device, accessing an abstract analog instruction set configured to cause an evolution in the selected target quantum device, and compiling the Hamiltonian equation to generate a pulse schedule based on the abstract analog instruction set for the target quantum device. |
| FILED | Friday, April 28, 2023 |
| APPL NO | 18/140856 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119367 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | George Mason University (Fairfax, Virginia); Oakland University (Rochester, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiliang Li (Fairfax, Virginia); Pei Dong (Fairfax, Virginia); Xiaozhou Huang (Manassas, Virginia); Yaonian Li (Fairfax, Virginia); Zhe Wang (Rochester, Michigan) |
| ABSTRACT | A machine-learning based VOC detection and identification method and an apparatus and system for implementing same. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/480429 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4162 (20130101) G01N 27/4168 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120118 | Aleshin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TerraPower, LLC (Bellevue, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Artem Aleshin (Newcastle, Washington); Joonhyung Choi (Lexington, South Carolina); Jason R. Moore (Chapin, South Carolina) |
| ABSTRACT | A masking element with an opening is disposed on the side of a core support structure. A flow stack wall defines a plurality of inlets. At least one inlet aligns with the masking element opening when the flow stack is mated with the masking element. A flow control assembly within the flow stack is configured to restrict flow of fluid within the flow stack. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482704 |
| CURRENT CPC | Nuclear Reactors G21C 1/32 (20130101) G21C 19/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120428 | Shao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qinghui Shao (Fremont, California); Lars F. Voss (Livermore, California) |
| ABSTRACT | Devices, methods and techniques related to high voltage and high-power diamond transistors are disclosed. In one example aspect, a switch operable under high-voltage and high-power includes a P-type diamond layer doped with an acceptor material, a first N-type diamond layer doped with a donor material and in contact with one side of the P-type diamond layer, a light blocking layer comprising the one or more apertures configured to allow the light to enter the first N-type diamond layer, a source contact and a drain contact that are at least partially in contact with the P-type diamond layer, and the gate in contact with at least an area of the first N-type diamond layer that corresponds to one of the one or more apertures. The gate can be positioned on the backside of the substrate. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/480996 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/1602 (20130101) H01L 31/028 (20130101) H01L 31/1126 (20130101) Original (OR) Class H01L 31/02164 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120456 | KOHL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PAUL KOHL (Atlanta, Georgia); MRINMAY MANDAL (Atlanta, Georgia) |
| ABSTRACT | An electrochemical device (100) includes an ion exchange membrane (120), a first electrode (110) adjacent to a first side thereof and a second electrode (130) adjacent to a second side thereof. At least one of the first electrode (110) and the second electrode (130) includes a current collector layer (112, 132) and a catalyzing layer (114, 134) applied thereto. The catalyzing layer (114, 134) includes an ion-conducting polymer (116), a plurality of electroactive catalyst particles (115, 118) and an adhesive (118) that binds the polymer (116), the catalyst particles (115, 118) and the current collector layer together (112, 132). In a method of making an electrode, an ion-conducting polymer, a plurality of electroactive catalyst particles and an adhesive are mixed in a solvent, which is applied to a current collector layer. The solvent is evaporated so that the adhesive binds the polymer and the catalyst particles to the current collector. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 18/276792 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/04 (20130101) Original (OR) Class H01M 4/8878 (20130101) H01M 6/181 (20130101) H01M 8/1018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120504 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Li (Manhattan, Kansas); Archana Sekar (Manhattan, Kansas) |
| ABSTRACT | Methods of making and using an improved electrochemical catalyst are provided herein. Catalysts as described herein include a carbon-containing support at least partially coated with a transition metal oxide shell. Catalytic nanoparticles, such as platinum nanoparticles, ruthenium nanoparticles, and/or PtRu alloy nanoparticles, are dispersed in and/or on the shell. The catalysts exhibit enhanced long-term stability and electrochemical activity, particularly with respect to the oxidation of methanol. Microwave-assisted synthesis and thermal annealing steps make the process of producing these catalysts both efficient and more easily scalable. The resulting catalysts have a wide range of end uses in renewable energy applications, including various types of fuel cells. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/476651 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/921 (20130101) H01M 4/926 (20130101) Original (OR) Class H01M 4/8882 (20130101) H01M 4/9016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120506 | TOUR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | James Mitchell TOUR (Houston, Texas); Weiyin CHEN (Houston, Texas); Duy X. LUONG (Houston, Texas); Carter KITTRELL (Houston, Texas) |
| ABSTRACT | Method and system for flash recycling of batteries, including lithium-ion batteries, other metal (sodium, potassium, zinc, magnesium, and aluminum)-ion batteries, metal batteries, batteries having all metal oxide cathodes, and batteries having graphite-containing anodes. The method and system include a solvent-free and water-free flash Joule heating (FJH) method performed upon a mixture that includes materials from the batteries done in millisecond for recycling the materials. In some embodiments, the FJH method is combined with magnetic separation to recover lithium, cobalt, nickel, and manganese with high yields up to 98%. In some embodiments, the FJH method is followed by rinsing with dilute acid, such a 0.01 M HCl. In other embodiments, the FJH method is utilized to purify the graphite in the battery, such as for use in the anode of the battery. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 18/264646 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 6/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120568 | SMITH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kandler Alan SMITH (Golden, Colorado); Shriram SANTHANAGOPALAN (Broomfield, Colorado); Nathaniel Alexander SUNDERLIN (Golden, Colorado); Andrew Michael COLCLASURE (Morrison, Colorado); Chunmei BAN (Golden, Colorado); Xuemin LI (Lakewood, Colorado); Judy C. NETTER (Westminster, Colorado); Donal Patrick FINEGAN (Golden, Colorado); Kaitlin Elizabeth FINK (Lakewood, Colorado); Jaclyn Elizabeth COYLE (Westminster, Colorado) |
| ABSTRACT | Among other things, the present disclosure relates to re-purposing used lithium-ion batteries. The present disclosure includes treating an electrode using a solvent prior to electrochemically relithiating the electrode. In some embodiments, the relithiation may be done using a roll-to-roll device, wherein the electrode may be secured on a first pin and a second pin, then it may be unwound and submerged in an electrolyte solution. Lithium ions may be inserted into the electrode using a voltage. The layer of lithium may provide lithium ions to the electrode. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529818 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/049 (20130101) H01M 4/139 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0587 (20130101) H01M 2004/8689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120739 | Miranbeigi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammadreza Miranbeigi (Atlanta, Georgia); Rajendra Prasad Kandula (Atlanta, Georgia); Deepak M. Divan (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a power converter system comprising a power converter. The power converter system can comprise a power converter electrically connected to a local power supply and an electrical utility grid. The power converter can comprise an output configured to exchange electrical power with the electrical utility grid. The power converter can be further configured to monitor one or more electrical parameters of the electrical utility grid over a period of time and alter one or more electrical parameters of the output of the power converter based on the monitored one or more electrical parameters of the electrical utility grid in real time using a deep learning neural network. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 18/276360 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/01 (20130101) H02J 3/1835 (20130101) Original (OR) Class H02J 13/00006 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120789 | Benedict et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Moble Benedict (College Station, Texas); Chase B. Wiley (Keller, Texas); Bansi Jayesh Patel (Bryan, Texas); Karanveer Shyamdhar Dubey (College Station, Texas) |
| ABSTRACT | A composite rotor for an electric motor includes an annular composite support plate extending radially relative a central axis of the composite rotor between an inner diameter defining a central opening of the composite support plate and an outer diameter, wherein the composite support plate includes a quasi-isotropic composite material, and an annular magnet assembly extending around the central axis of the composite rotor and coupled to a surface of the composite support plate. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/377688 |
| CURRENT CPC | Dynamo-electric Machines H02K 1/28 (20130101) Original (OR) Class H02K 1/146 (20130101) H02K 1/182 (20130101) H02K 1/2795 (20220101) H02K 21/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240115742 | Montclare et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin Kim Montclare (New York, New York); Dustin Britton (Brooklyn, New York); Youssef Zaim Wadghiri (New York, New York); Farbod Mahmoudinobar (Harrison, New Jersey) |
| ABSTRACT | Provided are proteins/peptides. The proteins or peptides comprise a sequence designed by the methods described herein. The proteins and peptides may have one or more trifluoroleucine (LTF, which may be referred to as TFL or LTF throughout) residues. The proteins may have or contain the following sequence: VX1X2X3X4X5X6X7X8X9X10X11X12X13X14X15X16X17X18X19X20X21X22X23X24X25X26X27X28X29X30X31X32X33X34X35X36X37 (SEQ ID NO:1), where X1 is A, E, D, R, H, K, Q, N, or S; X2 is A, E, N, or Q; X3 is A, V, L, I, Q, M, or LT; X4 is A, E, R, D, H, I, L, T, K, Q, N, or LT; X5 is A, F, Q, R, K, H, D, S, or E; X6 is A, L, I, or LTF; X7 is A, K, or E; X8 is A, K, E, D, R, H, Q, or N; X9 is A, T, I, L, Q, or LTF; X10 is A, L, I, or LT; X11 is A, E, D, H, P, I, L, K, Y, N, Q, R, or LT; X12 is A, Q, H, E, D, K, R, or N; X13 is A, M, I, L, Q, T, or LTF; X14 is A, L, D, E, K, I, or LTF; X15 is A, E, D, H, Y, I, L, R, K, Q, N, or Lu; X16 is A, E, or Q; X17 is A, L, M, I, V, or LTF; X18 is A, K, E, D, K, R, H, N, or Q; X19 is A, N, D, K, R, H, Q, or E; X20 is A, L, T, I, M, R, or LTF; X21 is A, N, or Q; X22 is K, A, E, I, L, M, R, H, D, Q, N, S, or LTF; X23 is A, Q, N, I, L, or LTF; X24 is A, L, I, M, T, or LT; X25 is A, H, Q, R, K, D, N, Y, I, E, L, T, or LT; X26 is A, D, E, R, K, Q, H, N, or T; X27 is A, V, I, Q, L, T, or LTF; X28 is A, R, E, D, K, H, N, Q, or T; X29 is A, H, E, R, D, K, I, L, N, Q, T, Y, or LTF; X30 is L, A, D, K, I, N, Q, or LTF; X31 is A, L, Q, I, or LTF; X32 is E, D, K, H, N, Q, A, L, R, I, Y, or LTF; X33 is A, N, Q, D, E, H, K, R, or S; X34 is Q, I, L, A, M, or LT; X35 is S, A, P, or Q; X36 is A, K, T, D, R, H, N, Q, or E; X37 is A, L, I, K, D, N, Q, R, or LTF; where at least one of X3, X4, X6, X9, X10, X11, X13, X14, X15, X16, X17, X20, X22, X23, X24, X25, X27, X29, X30, X31, X32, X34, X37 or any L is replaced with LTF. The proteins and peptides may have desirable self-assembling properties such that they form supramolecular structures (e.g., fibers or fibrils). The supramolecular structures may further gelate water such that a hydrogel is formed. The fibers and/or gels may be used to deliver drugs and/or as theranostic agents. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/460519 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/14 (20130101) A61K 49/222 (20130101) A61K 49/1884 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Peptides C07K 14/245 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/08 (20130101) G01N 29/34 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115859 | STEINHARDT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Cynthia STEINHARDT (Penn Valley, Pennsylvania); Gene FRIDMAN (Baltimore, Maryland) |
| ABSTRACT | A system and method for neural implant processing is disclosed. The method includes receiving, at a receiver of a neural implant, an input activation pattern; processing, by a front-end processing algorithm, the input activation pattern to produce a target population firing pattern for one or more neurons; and transforming, by a back-end processing algorithm, the target population firing pattern to a simulation pattern that induces a response with naturalistic timing. The neural implant includes a cochlear implant, a vestibular implant, a retinal vision prostheses, a deep brain stimulator, or a spinal cord stimulator. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/277179 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0543 (20130101) A61N 1/36038 (20170801) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 25/606 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116006 | Linic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suljo Linic (Ann Arbor, Michigan); James Wortman (Ann Arbor, Michigan); Rawan Almallahi (Ann Arbor, Michigan) |
| ABSTRACT | A catalyst system for propane dehydrogenation includes a hollow fiber members packed with a Pt1Sn1/SiO2 catalyst. The hollow fiber membrane includes a separation layer coated on an interior surface of a support tube. The separation layer selectively removes H2 generated during the propane dehydrogenation reaction. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/376332 |
| CURRENT CPC | Separation B01D 53/22 (20130101) B01D 69/08 (20130101) B01D 69/145 (20130101) Original (OR) Class B01D 71/025 (20130101) B01D 2257/108 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/08 (20130101) B01J 23/626 (20130101) B01J 35/0013 (20130101) B01J 35/065 (20130101) B01J 35/1061 (20130101) B01J 37/0201 (20130101) Acyclic or Carbocyclic Compounds C07C 5/48 (20130101) C07C 2523/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116007 | Sirkar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institude of Technology (Newark, New Jersey) |
| INVENTOR(S) | Kamalesh Sirkar (Bridgewater, New Jersey); Yufeng Song (Newark, New Jersey) |
| ABSTRACT | A module for gas and/or vapor removal from a fluid stream is provided. The module includes at least one hollow fiber membrane including a first end and an opposing second end. The hollow fiber membrane includes a fiber wall defining an interior bore extending from the first end to the opposing second end and defining a passage for fluid flow through the hollow fiber membrane. The module includes a bed of metal organic framework (MOF) integrated into membrane pores of the fiber wall of the at least one hollow fiber membrane, into the hollow fiber membrane bore, and/or outside of the at least one hollow fiber membrane in an extracapillary space. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/377482 |
| CURRENT CPC | Separation B01D 15/10 (20130101) B01D 53/04 (20130101) B01D 53/229 (20130101) B01D 63/04 (20130101) B01D 69/02 (20130101) B01D 69/08 (20130101) B01D 69/147 (20130101) Original (OR) Class B01D 71/028 (20130101) B01D 2253/204 (20130101) B01D 2325/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116169 | Su |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao Su (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to control of a wearable robot without torque sensors. In one example, a method includes generating a control signal for a quasi-direct-drive (QDD) actuator of the wearable robot and adjusting operation of the QDD actuator based upon the control signal. The control signal can be determined by a collocated controller using current and angle of rotation of the QDD actuator and a reference trajectory angle. In another example, a wearable robot includes a support structure that can interface with a user; a quasi-direct-drive (QDD) actuator coupled to the support structure; and processing circuitry that can generate a control signal for the QDD actuator, the control signal determined by a collocated controller based upon current and angle of rotation of the QDD actuator and a reference trajectory angle and adjust operation of the QDD actuator based upon the control signal. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/372630 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 3/00 (20130101) A61H 2205/06 (20130101) A61H 2205/088 (20130101) A61H 2205/102 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) Original (OR) Class B25J 9/1633 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116170 | Luo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shuzhen Luo (Raleigh, North Carolina); Hao Su (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to continuous control of exoskeletons. In one example, a method includes obtaining IMU sensor signals associated with an exoskeleton attached to a limb of a subject; generating an exoskeleton control signal in response to the IMU sensor signals, the exoskeleton control signal generated by a control policy neural network trained offline from the exoskeleton using musculoskeletal human modeling and exoskeletal modeling with dynamics randomization; and controlling joint torques of the exoskeleton exerted on the subject based upon the exoskeleton control signal. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/375797 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) Original (OR) Class B25J 9/163 (20130101) B25J 9/1615 (20130101) B25J 9/1633 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116653 | Cooley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lance D. Cooley (Tallahassee, Florida); Christian M. Hubicki (Tallahassee, Florida) |
| ABSTRACT | Example coil guns and methods of using coil guns are described herein. An example coil gun includes a first pancake module; a second pancake module, where the first pancake module and the second pancake module are each formed of a winding with an inner superconducting material layer and an outer ordinary conductor layer, where the first pancake module and the second pancake module are physically and/or inductively coupled to propagate a quench of a superconducting state of the first pancake module to the second pancake module. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992588 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/002 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/02 (20130101) H01F 6/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240116984 | Del Valle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan Del Valle (South Bend, Indiana); Kamlesh Makwana (South Bend, Indiana); Matthew Sarnowski (South Bend, Indiana) |
| ABSTRACT | Described herein are N-amino peptides (NAPs) that inhibit disease-associated tau aggregation and prevent fibril formation. The NAPs are derived from the R2 and R3 domains of tau (VQIINK and VQIVYK, respectively) wherein the amide moiety is N-aminated. N-amination of the R2 and R3 domains of tau results in formation of soluble mimics of ordered β-strands that are aggregation resistant and can assemble into layered parallel β-sheets. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 18/263190 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240117076 — NICKEL CATALYSTS WITH SINGLE METAL CATIONS FOR HOMOPOLYMERIZATION AND COPOLYMERIZATION
| US 20240117076 | Do et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| INVENTOR(S) | Loi H. Do (Manvel, Texas); Thi V. Tran (Houston, Texas) |
| ABSTRACT | This invention relates to nickel catalysts with alkali ions for homopolymerization and copolymerization. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/983170 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/06 (20130101) C08F 4/7098 (20130101) Original (OR) Class C08F 210/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117115 | Coates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Brooks Abel (Ithaca, New York); Rachel Snyder (Ithaca, New York); Holley Grace Hester (Ithaca, New York) |
| ABSTRACT | Poly(cyclic acetal)s, methods of making same, and uses of same. The poly(cyclic acetal)s may have a number average molecular weight (Mn) of 10 to 3000 kiloDaltons (kDa) and over 50% of the chain ends may exclude hydroxyl groups. The poly(cyclic acetal) may be a homopolymer or copolymer(s) of poly(1,3-dioxolane) (PDXL). The poly(cyclic acetal)s may have one or more or all of: a thermal stability (Td,5%) of 337° C. to 392° C.; a thermal stability of (Td.50%) of 377° C. to 462° C.; or an Arrhenius activation energy (Ea) of 85.0 kJ/mol with 2 mol % of strong acid (e.g., pKa less than or equal to 4). Methods of polymerizing poly(cyclic acetal)s may comprise reacting cyclic acetal monomers with either Lewis acid catalysts and haloalkyl ether initiators or organic cation salt catalyst(s) and proton traps. Methods of chemically recycling poly(cyclic acetal)s into cyclic acetals may react poly(cyclic acetal)s with strong acids. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 18/262509 |
| CURRENT CPC | Heterocyclic Compounds C07D 317/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/16 (20130101) Original (OR) Class C08G 65/266 (20130101) C08G 2650/22 (20130101) C08G 2650/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117292 | ENTCHEVA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emilia ENTCHEVA (Washington, District of Columbia); Christianne Joan CHUA (Washington, District of Columbia) |
| ABSTRACT | Embodiments of the instant disclosure relate to compositions and methods of use thereof that allow for faster integration of acute cardiac pacing experiments compared to the direct genetic modification methods currently in use. Embodiments provided herein provide for spheroids that may be stored, transported, and deployed on site to confer optical pacing of cardiac tissue for use in high-throughput functional in vitro screening assays. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/509951 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/362 (20130101) Apparatus for Enzymology or Microbiology; C12M 35/02 (20130101) Original (OR) Class C12M 35/04 (20130101) C12M 35/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117320 | Gerecht et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sharon Gerecht (Durham, North Carolina); Danielle Yarbrough (Durham, North Carolina); Franklyn Hall (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides compositions, systems, and methods related to engineered vascular tissue models. In particular, the present disclosure provides compositions, systems, and methods pertaining to three-dimensional engineered vascular tissue models generated using vascular smooth muscle cells which emulate the structure and functionality of human vasculature. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/484137 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0691 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2533/30 (20130101) C12N 2533/50 (20130101) C12N 2533/70 (20130101) C12N 2539/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118129 | ZHOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qin ZHOU (Fremont, California); Alexander K. ZETTL (Kensington, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to an ultrasonic microphone and an ultrasonic acoustic radio. In one aspect a system includes a transmitter and a receiver. The receiver comprises a membrane. The membrane comprises a single layer or multiple layers of a two-dimensional material. The receiver is operable to receive sound waves in a frequency range, with the frequency range being the ultrasonic frequency range. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/534337 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 3/12 (20130101) G01H 11/06 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/104 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 1/08 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118237 | Alba Rubio et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Toledo (Toledo, Ohio) |
| ASSIGNEE(S) | The University of Toledo (Toledo, Ohio) |
| INVENTOR(S) | Ana C. Alba Rubio (Toledo, Ohio); Dong-shik Kim (Toledo, Ohio); Haidar Alolaywi (Toledo, Ohio) |
| ABSTRACT | A sensor for formaldehyde gas, methods of making the same, and methods of using the same, are described. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 18/265788 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/48 (20130101) G01N 27/4076 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118269 | Manda et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swathi Manda (Cambridge, Massachusetts); Ashwin Gopinath (Boston, Massachusetts) |
| ABSTRACT | What is described herein is a device for sensing a target, comprising a planar array of unique stochastic sensors, wherein each sensor is weakly cross-reactive with a unique determinant on the target; a means for capturing electrical signals from each sensor and the temporal duration of each signal; and a means for analyzing the cumulative signals from the array of stochastic sensors, and optionally further comprising a computer system for processing an algorithm for identifying the target based on the electrical signals from the sensors of the device. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/476272 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4473 (20130101) G01N 33/5308 (20130101) Original (OR) Class G01N 33/5438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118472 | Kolle et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Mathias Kolle (Hull, Massachusetts); Benjamin Miller (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure describes photonic materials that reversibly change color in response to the material being stretched or otherwise mechanically deformed. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545117 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) G02B 5/287 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118786 | Ramani et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karthik Ramani (West Lafayette, Indiana); Xun Qian (West Lafayette, Indiana); Tianyi Wang (West Lafayette, Indiana); Fengming He (West Lafayette, Indiana) |
| ABSTRACT | A method and system for hand-object interaction dataset collection is described herein, which is configured to support user-specified collection of hand-object interaction datasets. Such hand-object interaction datasets are useful, for example, for training 3D hand and object pose estimation model. The method and system adopt a sequential process of first recording hand and object pose labels by manipulating a virtual bounding box, rather than a physical object. Naturally, hand-object occlusions do not occur during the manipulation of the virtual bounding box, so these labels are provided with high accuracy. Subsequently, the images are separately captured of the hand-object interaction with the physical object. These images are paired with the previously recorded hand and object pose labels. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/480134 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/017 (20130101) G06F 3/04815 (20130101) Original (OR) Class G06F 3/04842 (20130101) G06F 3/04845 (20130101) Image Data Processing or Generation, in General G06T 7/74 (20170101) G06T 7/194 (20170101) G06T 2207/20081 (20130101) G06T 2207/30196 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119015 | Sharma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shruti Sharma (Beaverton, Oregon); Robert Pawlowski (Beaverton, Oregon) |
| ABSTRACT | Systems, apparatuses and methods may provide for technology that detects a condition in which a plurality of atomic instructions target a common address and different bit positions in a mask, generates a combined read-lock request for the plurality of atomic instructions in response to the condition, and sends the combined read-lock request to a lock buffer coupled to a memory device associated with the common address. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458462 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/526 (20130101) G06F 13/1673 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119337 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Qian XU (Chicago, Illinois); LIANG JIANG (Chicago, Illinois) |
| ABSTRACT | The present disclosure describes various methods, systems, and storage medium for engineering fast bias-preserving gates on stabilized cat qubits. One method for performing a quantum operation on a qubit using a noise-bias-preserving (NBP) quantum gate includes obtaining and stabilizing the qubit; determining a type of the NBP quantum gate associated with the quantum operation, according to type of the NBP quantum gate, the quantum operation on the qubit to obtain a modified qubit, the quantum operation comprising a base gate drive and a counterdiabatic (CD) control drive. Another method for stabilizing a qubit for quantum storage includes obtaining a qubit; in response to the qubit being in an idle state, applying a two-photon dissipation operation on the qubit to stabilize the qubit, the two-photon dissipation operation corresponding to a two-photon drive. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 18/272410 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) G06N 10/70 (20220101) Original (OR) Class Pulse Technique H03K 17/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119729 | MANOHAR et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baalaganapathy MANOHAR (Lexington, Kentucky); Rahul AGGARWAL (Gainesville, Florida); University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baalaganapathy MANOHAR (Gainesville, Florida); Rahul AGGARWAL (Gainesville, Florida); Ravi S. SRINIVASAN (Gainesville, Florida); Sourabh KAKADE (Gainesville, Florida); Qusai NALAWALA (Gainesville, Florida) |
| ABSTRACT | The present disclosure describes systems and methods for acquiring structural attributes of a building. One such method comprises acquiring, by one or more cameras of an unmanned aerial vehicle, infrared thermal and visible RGB aerial images of a building; identifying structural components of the building based on an infrared thermal aerial image, wherein a floor structure of the building is identified from a color change in the infrared thermal aerial image between the building and a foundation structure of the building; positioning a bounding box around the floor structure of the building present in the infrared thermal aerial image; and estimating a lowest floor elevation of the building by calculating a lowest floor elevation value based on an amount of image pixels representing a distance between a top of the bounding box and a top of the foundation structure of the building. Other methods and systems are also provided. |
| FILED | Monday, November 08, 2021 |
| APPL NO | 18/035903 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/12 (20170101) G06T 2207/10024 (20130101) G06T 2207/10032 (20130101) G06T 2207/10048 (20130101) G06T 2207/30184 (20130101) Image or Video Recognition or Understanding G06V 10/26 (20220101) G06V 20/176 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119746 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Teng-Chieh Liu (Seattle, Washington); Weisi Xie (Seattle, Washington); Nicholas P. Reder (Seattle, Washington) |
| ABSTRACT | Apparatuses, systems, and methods for synthetic 3D digital microscopy image sets. A microscope captures a depth stack of a sample using a first labelling technique. A trained machine learning model generates a synthetic depth stack of images based on the imaged depth stack. The synthetic depth stack mimics the appearance of a second labelling technique, which is targeted to a tissue structure of interest. A segmentation mask is generated based on the synthetic depth stack. The machine learning model may be trained on depth stacks of samples prepared with both the first and the second labelling techniques. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 18/271203 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4038 (20130101) G06T 7/11 (20170101) G06T 11/00 (20130101) Image or Video Recognition or Understanding G06V 20/70 (20220101) G06V 20/695 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120021 | Shendure et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Shendure (Seattle, Washington); Andrew Adey (Seattle, Washington); Joshua Burton (Seattle, Washington); Jacob Kitzman (Seattle, Washington); Maitreya J. Dunham (Seattle, Washington); Ivan Liachko (Seattle, Washington) |
| ABSTRACT | Computational methods used for large scale scaffolding of a genome assembly are provided. Such methods may include a step of applying a location clustering model to a test set of contigs to form two or more location cluster groups, each location cluster group comprising one or more location-clustered contigs; a step of applying an ordering model to each of the two or more location cluster groups to form an ordered set of one or more location-clustered contigs within each cluster group; and a step of applying an orienting model to each ordered set of one or more location-clustered contigs to assign a relative orientation to each of the location-clustered contigs within each location cluster group. In some aspects, the test set of contigs are generated from aligning a set of reads generated by a chromosome conformation analysis technique (e.g., Hi-C) with a draft assembly, a reference assembly, or both. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311775 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 30/20 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120125 | HUANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shilin HUANG (Durham, North Carolina); Ye WANG (Durham, North Carolina); Kenneth BROWN (Durham, North Carolina) |
| ABSTRACT | Technologies for suppressing effects of crosstalk in a quantum circuit of a quantum computing system are disclosed. A pair of target qubits on which to perform a quantum gate operation is selected. The quantum gate operation is performed. A rotation is induced on the target qubits such that crosstalk between any of the target qubits and any of the neighboring qubits in the quantum circuit is canceled out. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/107942 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120172 | Dravid et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinayak P. Dravid (Glenview, Illinois); Xiaobing Hu (Evanson, Illinois); Kunmo Koo (Skokie, Illinois) |
| ABSTRACT | Method for fabricating a microchip are provided which may comprise forming a dopant mask layer on a front side surface of a silicon substrate having the front side surface and an opposing back side surface; removing a portion of the dopant mask layer according to a pattern to form a first exposed silicon region in the silicon substrate and a first unexposed silicon region in the silicon substrate; doping the first exposed silicon region in the silicon substrate with a p-type dopant to form a first p-type doped silicon region in the silicon substrate; forming a silicon nitride layer on the front side surface of the silicon substrate comprising the first p-type doped silicon region and the first unexposed silicon region; and forming an opening in the silicon substrate from the opposing back side surface of the silicon substrate to provide a microchip comprising the silicon substrate having the opening, a first silicon nitride window positioned within the opening, and a support structure mounted to the first silicon nitride window, the support structure comprising the first p-type doped silicon region. The fabricated microchips and methods of using the microchips are also provided. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/479994 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00119 (20130101) B81C 2201/0133 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/26 (20130101) H01J 37/244 (20130101) Original (OR) Class H01J 2237/24455 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120504 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Li (Manhattan, Kansas); Archana Sekar (Manhattan, Kansas) |
| ABSTRACT | Methods of making and using an improved electrochemical catalyst are provided herein. Catalysts as described herein include a carbon-containing support at least partially coated with a transition metal oxide shell. Catalytic nanoparticles, such as platinum nanoparticles, ruthenium nanoparticles, and/or PtRu alloy nanoparticles, are dispersed in and/or on the shell. The catalysts exhibit enhanced long-term stability and electrochemical activity, particularly with respect to the oxidation of methanol. Microwave-assisted synthesis and thermal annealing steps make the process of producing these catalysts both efficient and more easily scalable. The resulting catalysts have a wide range of end uses in renewable energy applications, including various types of fuel cells. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/476651 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/921 (20130101) H01M 4/926 (20130101) Original (OR) Class H01M 4/8882 (20130101) H01M 4/9016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120543 | Rustomji et al. |
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| FUNDED BY |
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| APPLICANT(S) | SOUTH 8 TECHNOLOGIES, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cyrus S. Rustomji (San Diego, California); Jungwoo Lee (San Diego, California); James Royer (San Diego, California); Miguel Ceja (Manteca, California) |
| ABSTRACT | A safe electrolyte which comprises a liquefied gas solvent that will transition from a liquid state to a gas state (“gas off”) at a pressure of 100 kPa and temperature of 293.15 K is further disclosed. A first mixture is formed from a first electrolyte component (one or more solvents) mixed with a second electrolyte component (one or more hydrocarbon co-solvents). The addition of the second electrolyte component (1) lowers the vapor pressure of the first mixture by at least 10% as compared to the vapor pressure of the first electrolyte component alone when measured at 293.15 K and (2) results in a vapor pressure of the first mixture above 100 kPa at a temperature of 293.15 K. The second electrolyte component may also be selected to lower the global warming potential (GWP) of the first mixture by at least 10% as compared to GWP of the first electrolyte component alone. The safe liquefied gas electrolyte is formed by mixing a third electrolyte component (one or more salts) to the first mixture. This safe liquefied gas electrolyte can then be used to manufacture an electrochemical energy storage device. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/383255 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0567 (20130101) Original (OR) Class H01M 10/0569 (20130101) H01M 50/183 (20210101) H01M 2300/0028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240121620 | IBRAHIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| INVENTOR(S) | Mohamed Salaheldeen IBRAHIM (Charlottesville, Virginia); Nikolaos Dimitrios Sidiropoulos (Keswick, Virginia) |
| ABSTRACT | Embodiments relate to a dynamic spectrum access (DSA) system including a DSA transmitter configured to generate a complex signal for a secondary communication system, the complex signal being within a communication band A that is equal to or falls within a communication band B of a primary communication system. The complex signal includes a first signal and a second signal that is a repeat of the first signal. The power of the complex signal received at the secondary communication receiver is greater than the noise floor of the secondary communication system, but is equal to or less than the interference power from the primary communication. The DSA system includes a DSA receiver including a plurality of DSA antennas and a DSA signal processing module, the DSA signal processing module configured to perform canonical correlation analysis (CCA) on the complex signal. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 18/257188 |
| CURRENT CPC | Wireless Communication Networks H04W 16/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122082 | Sangwan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinod K. Sangwan (Evanston, Illinois); Hong-Sub Lee (Evanston, Illinois); Mark C. Hersam (Wilmette, Illinois) |
| ABSTRACT | One aspect of the invention relates to a method for fabricating a memtransistor comprising growing a polycrystalline monolayer film on a substrate, wherein the polycrystalline monolayer film contains grains defining a plurality of grain boundaries thereof; and forming an electrode array on the grown polycrystalline monolayer film, wherein the electrode array has a plurality of electrodes electrically coupled with the polycrystalline monolayer film such that each pair of electrodes defines a channel in the polycrystalline monolayer film therebetween. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538034 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) Static Stores G11C 13/0002 (20130101) Electronic Memory Devices H10B 63/30 (20230201) Electric solid-state devices not otherwise provided for H10N 70/023 (20230201) H10N 70/24 (20230201) H10N 70/253 (20230201) Original (OR) Class H10N 70/823 (20230201) H10N 70/841 (20230201) H10N 70/8822 (20230201) H10N 70/8825 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240118243 | Rasmussen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Grace Rasmussen (Boulder, Colorado); Mark Owen McLinden (Boulder, Colorado) |
| ABSTRACT | A high-temperature and high-pressure speed of sound apparatus measures the speed of sound in a sample at high-temperature and high-pressure, the apparatus includes: a defined-length spacer that has a fixed length spacer portion; an acoustic reflector, such that a crucible is interposed between the acoustic reflector and a pressure vessel, the pressure vessel in which is disposed the crucible, the disposed defined-length spacer, the sample, an acoustic reflector, and an acoustic rod; and the acoustic rod on which is disposed an ultrasonic transducer. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482243 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/024 (20130101) Original (OR) Class G01N 29/227 (20130101) G01N 29/228 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119034 | Daimler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Conexus ai, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Alexander Daimler (San Francisco, California); Ryan Jacob Wisnesky (San Francisco, California); David Isaac Spivak (Somerville, Massachusetts) |
| ABSTRACT | A data migration and integration system is disclosed. In various embodiments, the system includes a memory configured to store a mapping from a source schema to a target schema; and a processor coupled to the memory and configured to migrate to a target schema an instance of source data organized according to the source schema, including by using a chase engine to perform an ordered sequence of steps comprising adding a bounded layer of new elements to a current canonical chase state associated with migrating the source data to the target schema; adding coincidences associated with one or more of the target schema data integrity constraints and a mapping from the source schema to the target schema; and merging equal elements based on the coincidences; and repeat the preceding ordered sequence of steps iteratively until an end condition is met. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/212320 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/86 (20190101) G06F 16/182 (20190101) G06F 16/211 (20190101) G06F 16/214 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119035 | Wisnesky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Conexus ai, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Jacob Wisnesky (San Francisco, California); Joshua Meyers (New York, New York); Eric Alexander Daimler (San Francisco, California) |
| ABSTRACT | A system and method are disclosed for merging multiple spreadsheets into one sheet, and/or exchanging data among the sheets, by expressing each sheet's formulae as an algebraic (equational) theory and each sheet's values as a model of its theory, and then performing one or more of “Kan-extension”, “psuedo-colimit”, and “lifting”, and constructions from category theory, to compute a canonically “universal” integrated theory and model, which can then be expressed as a spreadsheet and from which projections back to the sources are easily constructed. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/374360 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/86 (20190101) G06F 16/182 (20190101) G06F 16/211 (20190101) G06F 16/214 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120706 | Papp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Brian Papp (Boulder, Colorado); Jennifer Anne Black (Boulder, Colorado) |
| ABSTRACT | A method of designing a continuous-wave laser source having a target output wavelength and an input laser with a wavelength different from the target output wavelength includes the steps of receiving the target output wavelength, and subordinate properties of the laser source; determining a candidate wavelength of the input laser and materials of the substrate, lower cladding, photonic device layer (PDL), and upper cladding; producing an optimal design of a photonic crystal resonator (PhCR) enabling optical parametric oscillation (OPO); and producing an optimal design of the input and output PhCR waveguide couplers. The OPO is phase-matched. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/483926 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/11 (20210101) H01S 5/026 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122082 | Sangwan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinod K. Sangwan (Evanston, Illinois); Hong-Sub Lee (Evanston, Illinois); Mark C. Hersam (Wilmette, Illinois) |
| ABSTRACT | One aspect of the invention relates to a method for fabricating a memtransistor comprising growing a polycrystalline monolayer film on a substrate, wherein the polycrystalline monolayer film contains grains defining a plurality of grain boundaries thereof; and forming an electrode array on the grown polycrystalline monolayer film, wherein the electrode array has a plurality of electrodes electrically coupled with the polycrystalline monolayer film such that each pair of electrodes defines a channel in the polycrystalline monolayer film therebetween. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538034 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) Static Stores G11C 13/0002 (20130101) Electronic Memory Devices H10B 63/30 (20230201) Electric solid-state devices not otherwise provided for H10N 70/023 (20230201) H10N 70/24 (20230201) H10N 70/253 (20230201) Original (OR) Class H10N 70/823 (20230201) H10N 70/841 (20230201) H10N 70/8822 (20230201) H10N 70/8825 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240115556 | Islam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cancer Research Technology Limited (London, United Kingdom); The Chancellor, Masters And Scholars Of The University Of Oxford (Oxford, United Kingdom); The Institute of Cancer Research: Royal Cancer Hospital (London, United Kingdom); University of Washington (Seattle, Washington); The United States Government represented by The Department Of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Md. Saiful Islam (Oxford, United Kingdom); Anthony Tumber (Oxford, United Kingdom); Christopher Schofield (Oxford, United Kingdom); Alec Paschalis (London, United Kingdom); Jonathan Welti (London, United Kingdom); Adam Sharp (London, United Kingdom); Johann de Bono (London, United Kingdom); Stephen Plymate (Seattle, Washington) |
| ABSTRACT | The invention relates to methods for treating prostate cancer by targeting the generation of splice variants of the androgen receptor. In one aspect, this can be achieved by targeting JMJD6 to reduce the production of androgen receptor splice variants. The invention finds particular use in the treatment of prostate cancer that is resistant to conventional androgen therapy. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 18/257801 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115662 | ATWOOD |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin); UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig S. ATWOOD (Madison, Wisconsin) |
| ABSTRACT | Described herein are methods of inducing cognitive recovery of a subject suffering from a traumatic brain injury (TBI). The methods comprise administering to the subject pharmaceutical compositions including human chorionic gonadotropic (hCG) and/or luteinizing hormone (hLH), or a combination thereof. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 18/276871 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/57 (20130101) A61K 31/565 (20130101) A61K 31/567 (20130101) A61K 31/5685 (20130101) A61K 38/24 (20130101) Original (OR) Class A61K 38/1841 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117018 | Sajadi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United States Government as Represented by the Department of Veterans Affairs (Washington, D.C., District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Sajadi (Cockeysville, Maryland); George K. Lewis (Baltimore, Maryland); Anthony DeVico (Alexandria, Virginia) |
| ABSTRACT | The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof. |
| FILED | Tuesday, May 09, 2023 |
| APPL NO | 18/314490 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) C07K 2317/565 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119959 | HU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Qian HU (Lexington, Massachusetts); Brian P. Marx (Sharon, Massachusetts); Patricia D. King (Hampton, New Hampshire); Seth-David Donald Dworman (Bedford, Massachusetts); Matthew E. Coarr (Newton, Massachusetts); Keith A. Crouch (Cambridge, Massachusetts); Stelios Melachrinoudis (Framingham, Massachusetts); Cheryl Clark (Arlington, Massachusetts); Terence M. Keane (Boston, Massachusetts) |
| ABSTRACT | The present disclosure generally relates to a system and method for obtaining a diagnosis of a mental health condition. An exemplary system can receive an audio input; convert the audio input into a text string; identify a speaker associated with the text string; based on at least a portion of the audio input, determine a predefined audio characteristic of a plurality of predefined audio characteristics; based on the determined audio characteristic, identify an emotion corresponding to the portion of the audio input; generate a set of structured data based on the text string, the speaker, the predefined audio characteristic, and the identified emotion; and provide an output for obtaining the diagnosis of the mental disorder or condition, wherein the output is indicative of at least a portion of the set of structured data. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535641 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/16 (20130101) A61B 5/4803 (20130101) A61B 5/7267 (20130101) A61B 5/7282 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 17/00 (20130101) G10L 25/18 (20130101) G10L 25/63 (20130101) G10L 25/66 (20130101) Original (OR) Class G10L 25/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120032 | Mahajan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinit Mahajan (Redwood City, California); Young Joo Sun (Redwood City, California); Gabriel Velez (Redwood City, California); Dylan Parsons (Redwood City, California) |
| ABSTRACT | A high-resolution crystallographic structure of the mutant human G267S calpain-5 protease core domain at 2.22 Å resolution is provided. The G267S mutation is associated with hyperactivity of calpain-5 and is linked to the inherited disease, neovascular inflammatory vitreoretinopathy. Methods of using the crystallographic structure in rational design of small molecule drugs that inhibit calpain-5 for treatment of retinal diseases and other diseases associated with calpain-5 hyperactivity are also provided. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 18/030046 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6472 (20130101) Enzymes C12Y 304/22 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/30 (20190201) Original (OR) Class G16C 20/50 (20190201) G16C 20/64 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240114945 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345544 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1203 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/36 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) A23L 31/00 (20160801) Original (OR) Class A23L 33/195 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/208 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/00 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240115187 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Quan Zhang (Winchester, Massachusetts); Gary Strangman (Boxford, Massachusetts) |
| ABSTRACT | A system and a method is provided for assessing motion of a biological tissue of a subject including one or more superficial biological layers and a targeted biological layer. A perturbation unit provide an optical perturbation to the one or more superficial biological layers. An optical signal generator transmits optical signals at one or more near-infrared wavelengths. An optical signal receiver acquires a set of optical signal data preceding, during, or following the optical perturbation at a first acquisition time relative to the optical perturbation. A signal processor determines, using the set of optical signal data, a set of optical characteristics and separates, using the set of optical characteristics, a target optical signal. The signal processor generates a report indicative of a movement of the targeted biological tissue within the subject. The movement of the targeted biological layer is calculated using the target optical signal. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538583 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/4064 (20130101) Original (OR) Class A61B 5/6814 (20130101) A61B 5/14553 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117320 | Gerecht et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sharon Gerecht (Durham, North Carolina); Danielle Yarbrough (Durham, North Carolina); Franklyn Hall (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides compositions, systems, and methods related to engineered vascular tissue models. In particular, the present disclosure provides compositions, systems, and methods pertaining to three-dimensional engineered vascular tissue models generated using vascular smooth muscle cells which emulate the structure and functionality of human vasculature. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/484137 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0691 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2533/30 (20130101) C12N 2533/50 (20130101) C12N 2533/70 (20130101) C12N 2539/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117743 | Corsetti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Kenneth Corsetti (Reading, Massachusetts); John Curtis Calhoun (Cincinnati, Ohio); Dane Michael Dale (Cincinnati, Ohio) |
| ABSTRACT | An apparatus for an engine component in a turbine engine. The engine component including a wall with a cooling hole having a passage extending between an inlet fluidly coupled to a cooling fluid flow and an outlet at a heated surface. The cooling hole including a layup surface defining a first angle (α) and a layback surface defining a second angle (β). |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/960230 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/187 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/307 (20130101) F05D 2250/14 (20130101) F05D 2250/38 (20130101) F05D 2260/2214 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240118047 | Haydt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Space Systems International, Inc. (Windsor Locks, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shane E. Haydt (Manchester, Connecticut); Kimberly Rae Saviers (Glastonbury, Connecticut); Joshua M. Norman (South Windsor, Connecticut); Joseph C. Rampone (Colchester, Connecticut) |
| ABSTRACT | In accordance with at least one aspect of this disclosure, a system includes a liquid-gas separator. The liquid-gas separator comprises, a substantially planar body configured to be seated in a fluid flow to separate a flow of liquid from the fluid flow, one or more apertures disposed in the body configured collect the flow of liquid, and one or more diverters integrally formed on or in the body configured divert the flow of liquid towards the one or more apertures. In certain embodiments, the planar body can be additively manufactured. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/963120 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 9/005 (20130101) F28F 25/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240114945 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345544 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1203 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/36 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) A23L 31/00 (20160801) Original (OR) Class A23L 33/195 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/208 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/00 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119034 | Daimler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Conexus ai, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Alexander Daimler (San Francisco, California); Ryan Jacob Wisnesky (San Francisco, California); David Isaac Spivak (Somerville, Massachusetts) |
| ABSTRACT | A data migration and integration system is disclosed. In various embodiments, the system includes a memory configured to store a mapping from a source schema to a target schema; and a processor coupled to the memory and configured to migrate to a target schema an instance of source data organized according to the source schema, including by using a chase engine to perform an ordered sequence of steps comprising adding a bounded layer of new elements to a current canonical chase state associated with migrating the source data to the target schema; adding coincidences associated with one or more of the target schema data integrity constraints and a mapping from the source schema to the target schema; and merging equal elements based on the coincidences; and repeat the preceding ordered sequence of steps iteratively until an end condition is met. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/212320 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/86 (20190101) G06F 16/182 (20190101) G06F 16/211 (20190101) G06F 16/214 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240119035 | Wisnesky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Conexus ai, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Jacob Wisnesky (San Francisco, California); Joshua Meyers (New York, New York); Eric Alexander Daimler (San Francisco, California) |
| ABSTRACT | A system and method are disclosed for merging multiple spreadsheets into one sheet, and/or exchanging data among the sheets, by expressing each sheet's formulae as an algebraic (equational) theory and each sheet's values as a model of its theory, and then performing one or more of “Kan-extension”, “psuedo-colimit”, and “lifting”, and constructions from category theory, to compute a canonically “universal” integrated theory and model, which can then be expressed as a spreadsheet and from which projections back to the sources are easily constructed. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/374360 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/86 (20190101) G06F 16/182 (20190101) G06F 16/211 (20190101) G06F 16/214 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240114902 | CHA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by The Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DONG H. CHA (HILO, Hawaii); JUNWEI J. ZHU (LINCOLN, Nebraska) |
| ABSTRACT | Biocontrol compositions effective as fruit fly oviposition deterrents are disclosed. Compositions comprising at least two coconut free fatty acids (CFA), caprylic acid (C8:0) and capric acid (C10:0), and optionally a carrier are shown to be effective drosophilid oviposition-deterrents. Furthermore, other specific CFA are shown to reduce female B. dorsalis, Z. cucurbitae, and D. suzukii attraction and oviposition in response to host fruit odors. Kits comprising such biocontrol compositions, and methods of using such biocontrol compositions to reduce the population of fruit flies are also taught. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/477665 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/02 (20130101) Original (OR) Class A01N 37/06 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 17/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240117375 | Yerka |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada (Reno, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melinda Yerka (Reno, Nevada) |
| ABSTRACT | The present disclosure provides genetically edited or modified plants of the genus Sorghum and methods of producing genetically edited or modified plants of the genus Sorghum using, e.g., a CRISPR/Cas9 gene editing tool. In some embodiments, the genetic modifications are directed to genes of the Inhibition of Alien Pollen (IAP) locus to modulate cross-compatibility of the plants with other species of Sorghum. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/367282 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 15/8213 (20130101) C12N 15/8287 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20240119015 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shruti Sharma (Beaverton, Oregon); Robert Pawlowski (Beaverton, Oregon) |
| ABSTRACT | Systems, apparatuses and methods may provide for technology that detects a condition in which a plurality of atomic instructions target a common address and different bit positions in a mask, generates a combined read-lock request for the plurality of atomic instructions in response to the condition, and sends the combined read-lock request to a lock buffer coupled to a memory device associated with the common address. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458462 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/526 (20130101) G06F 13/1673 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240120125 | HUANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shilin HUANG (Durham, North Carolina); Ye WANG (Durham, North Carolina); Kenneth BROWN (Durham, North Carolina) |
| ABSTRACT | Technologies for suppressing effects of crosstalk in a quantum circuit of a quantum computing system are disclosed. A pair of target qubits on which to perform a quantum gate operation is selected. The quantum gate operation is performed. A rotation is induced on the target qubits such that crosstalk between any of the target qubits and any of the neighboring qubits in the quantum circuit is canceled out. |
| FILED | Thursday, February 09, 2023 |
| APPL NO | 18/107942 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20240117580 | SICKING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sicking Safety Systems LLC (Indian Springs Village, Alabama) |
| ASSIGNEE(S) | Sicking Safety Systems LLC (Indian Springs Village, Alabama) |
| INVENTOR(S) | Dean L. SICKING (Indian Springs Village, Alabama); Dakotah SICKING (Keller, Texas); Steven D. THOMPSON (Bessemer, Alabama); Kenneth WALLS (Trussville, Alabama); Kevin D. SCHRUM (Pelham, Alabama); Joseph SCHWERTZ (Birmingham, Alabama); David LITTLEFIELD (Vestavia Hills, Alabama); Andrew DAMERON (Birmingham, Alabama) |
| ABSTRACT | Guardrail, guardrail terminal, and support post designs that improve control of a vehicle during collisions are described. The disclosed designs also reduce the likelihood of intrusion into vehicle systems and the occupant compartment(s). Embodiments include folding and/or flattening of the guardrail and controlling the folded and flattened guardrail to avoid intrusion into the vehicle. Other embodiments include containing the guardrail in an impact head of a guardrail terminal, which also avoids vehicle intrusion. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/540497 |
| CURRENT CPC | Additional Work, Such as Equipping Roads or the Construction of Platforms, Helicopter Landing Stages, Signs, Snow Fences, or the Like E01F 15/143 (20130101) Original (OR) Class E01F 15/0423 (20130101) E01F 15/0461 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20240115610 | BHATNAGAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Parijat BHATNAGAR (Belmont, California); Marvin A. SSEMADAALI (Menlo Park, California) |
| ABSTRACT | An example antigen test device comprises a genetically engineered diagnostic cell comprising an exogenous polynucleotide sequence including a receptor element that encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain that recognizes an antigen on a surface of a pathogen-infected cell from a sample or on a surface of a virus particle associated with a pathogen from the sample, an actuator element that encodes a transcription factor binding site, and an effector element that encodes a detectable reporter protein, wherein, in response to the antigen binding domain of the CAR binding to the antigen, the genetically engineered diagnostic cell is configured to activate and to synthesize the detectable reporter protein. |
| FILED | Tuesday, June 13, 2023 |
| APPL NO | 18/333778 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/2803 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20240117580 | SICKING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sicking Safety Systems LLC (Indian Springs Village, Alabama) |
| ASSIGNEE(S) | Sicking Safety Systems LLC (Indian Springs Village, Alabama) |
| INVENTOR(S) | Dean L. SICKING (Indian Springs Village, Alabama); Dakotah SICKING (Keller, Texas); Steven D. THOMPSON (Bessemer, Alabama); Kenneth WALLS (Trussville, Alabama); Kevin D. SCHRUM (Pelham, Alabama); Joseph SCHWERTZ (Birmingham, Alabama); David LITTLEFIELD (Vestavia Hills, Alabama); Andrew DAMERON (Birmingham, Alabama) |
| ABSTRACT | Guardrail, guardrail terminal, and support post designs that improve control of a vehicle during collisions are described. The disclosed designs also reduce the likelihood of intrusion into vehicle systems and the occupant compartment(s). Embodiments include folding and/or flattening of the guardrail and controlling the folded and flattened guardrail to avoid intrusion into the vehicle. Other embodiments include containing the guardrail in an impact head of a guardrail terminal, which also avoids vehicle intrusion. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/540497 |
| CURRENT CPC | Additional Work, Such as Equipping Roads or the Construction of Platforms, Helicopter Landing Stages, Signs, Snow Fences, or the Like E01F 15/143 (20130101) Original (OR) Class E01F 15/0423 (20130101) E01F 15/0461 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240116080 | Moran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Charles Moran (Crofton, Maryland); Marlon Guy Wells (Fort Washington, Maryland) |
| ABSTRACT | This disclosure relates to systems and methods of integrated on-demand labeling of item containers. In particular, this disclosure relates systems and methods for automatically creating and using placards to label, track, and organize item containers and items. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/391444 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/14 (20130101) Original (OR) Class B07C 3/18 (20130101) B07C 3/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, April 11, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
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FUNDED BY
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Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
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3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
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The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
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