FedInvent™ Patent Applications
Application Details for Thursday, April 18, 2024
This page was updated on Tuesday, June 18, 2024 at 02:19 PM GMT
Department of Health and Human Services (HHS)
| US 20240122499 | Rajkumar et al. |
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| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashwin Rajkumar (Brooklyn, New York); Fabio Vulpi (Bari, Italy); Preeti Raghavan (Brooklyn, New York); Vikram Kapila (West Orange, New Jersey) |
| ABSTRACT | Disclosed is a wearable inertial sensors (WIS) system and methods for real-time simultaneous tri-planar motion capture of the upper extremity (UE). The sensors simultaneously capture in the frontal, sagittal, and horizontal planes UE range of motion (ROM), which is critical to assess an individual's movement limitations and determine appropriate rehabilitative treatments. Off-the-shelf sensors and microcontrollers are used to develop the WIS system, which wirelessly streams real-time joint orientation for UE ROM measurement. Key developments include: (i) two novel approaches, using earth's gravity (EG approach) and magnetic field (EGM approach) as references, to correct misalignments in the orientation between the sensor and its housing to minimize measurement errors; (ii) implementation of the joint coordinate system (JCS)-based method for tri-planar ROM measurements for clinical use; and (iii) an in-situ guided mounting technique for accurate sensor placement and alignment on human body. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 18/257609 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1071 (20130101) A61B 5/1114 (20130101) Original (OR) Class A61B 5/6823 (20130101) A61B 5/6824 (20130101) A61B 5/7475 (20130101) A61B 2560/0223 (20130101) A61B 2562/0219 (20130101) Card, Board, or Roulette Games; Indoor Games Using Small Moving Playing Bodies; Video Games; Games Not Otherwise Provided for A63F 13/211 (20140902) A63F 13/212 (20140902) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/40 (20180101) G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122524 | He et al. |
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| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin He (Pittsburgh, Pennsylvania); Haiteng Jiang (HangZhou, China PRC) |
| ABSTRACT | Provided is a method for locating an epilepsy seizure onset zone and prediction of seizure outcome including receiving interictal electroencephalographs from two or more points in a patient's cerebral cortex. The interictal electroencephalographs are used to determine directional information flow values which indicate dominant information flow from a non-seizure zone to a seizure onset zone. The directional informational flow values may be input into a classification model trained to predict whether the two or more points in the patient's cerebral cortex are a seizure onset zone and/or classify the patient's predicted post-treatment seizure outcome after epilepsy treatment based on the directional information flow values. An output from the classification model may indicate a location of seizure onset zone in the patient's cerebral cortex and/or the patient's predicted post-treatment seizure outcome after epilepsy treatment. Systems and computer program products are also provided. |
| FILED | Monday, February 21, 2022 |
| APPL NO | 18/277867 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/291 (20210101) A61B 5/374 (20210101) Original (OR) Class A61B 5/4094 (20130101) A61B 5/7264 (20130101) A61B 5/7275 (20130101) A61B 5/7282 (20130101) A61B 5/7435 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122529 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongming Li (Cambridge, Massachusetts); Angela Belcher (Lexington, Massachusetts) |
| ABSTRACT | This disclosure provides a method for imaging lymph nodes and lymphatic vessels without a contrast agent. The method includes providing, using an optical source, an infrared illumination to a region of a subject having at least one lymphatic component, detecting a reflected portion of the infrared illumination directly reflected from the region using a sensor positioned thereabout, and generating at least one image indicative of the at least one lymphatic component in the subject using the reflected portion of the infrared illumination. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538886 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0062 (20130101) A61B 5/0082 (20130101) A61B 5/418 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) G01N 21/35 (20130101) G01N 2021/3137 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122530 | KANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jeeun KANG (Baltimore, Maryland); Raymond C. KOEHLER (Baltimore, Maryland); Ernest M. GRAHAM (Clarksville, Maryland); Emad M. BOCTOR (Ellicott City, Maryland); Jennifer LEE-SUMMERS (Baltimore, Maryland) |
| ABSTRACT | The present disclosure is associated with monitoring health of a patient. An example photoacoustic monitoring device includes a light-guiding component to guide light energy toward tissue to cause the light energy to be absorbed by the tissue; an ultrasound transmission component to transmit acoustic energy toward the tissue to cause a biological response from the tissue; and a sensing component to perform one or more of ultrasound or photoacoustic imaging to sense the biological response from the tissue and permit a status of the tissue to be determined. In some implementations, the biological response is sensed based on the light energy absorbed by the tissue during the biological response caused by the acoustic energy transmitted toward the tissue. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/543277 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0095 (20130101) A61B 5/4064 (20130101) A61B 5/4362 (20130101) Original (OR) Class A61B 5/6823 (20130101) A61B 2503/02 (20130101) A61B 2503/045 (20130101) A61B 2560/0214 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122575 | Egorov |
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| FUNDED BY |
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| APPLICANT(S) | Advanced Tactile Imaging Inc. (Ewing Township, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Egorov (Princeton, New Jersey) |
| ABSTRACT | A cervix probe is equipped with a tactile sensor array and an ultrasound transducer and configured for simultaneous acquisition of stress data and ultrasound strain data for the same sector of the cervix. Acquired and recorded stress and strain data are transmitted to a data processor for calculating cervix elasticity and cervix length, followed by calculating a probability of spontaneous preterm delivery using a clinically validated predictive model. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/395293 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/12 (20130101) A61B 8/485 (20130101) Original (OR) Class A61B 8/4281 (20130101) A61B 8/4422 (20130101) A61B 8/4455 (20130101) A61B 8/4483 (20130101) A61B 8/5223 (20130101) A61B 90/06 (20160201) A61B 2090/064 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122582 | Thongpang et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); Mahidol University (Nakhon Pathom, Thailand) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanitta Thongpang (Seattle, Washington); Erwin Stefan Peter Berthier (Seattle, Washington); Damielle Leticia Hieber (Kenmore, Washington); Xiaojing Su (Seattle, Washington); Ashleigh Brooks Theberge (Seattle, Washington); Ulri Nicole Lee (Seattle, Washington) |
| ABSTRACT | Described herein is an oral sampling device, as well as methods of making and using the oral sampling device. The oral sampling device is configured to be placed inside of a human mouth to capture an analyte(s) found in bodily fluid, such as saliva, produced within the mouth. An example oral sampling device includes a body, at least a portion of which is sized to fit inside of a mouth of a human, has an outer surface, and a recess(es) defined in the outer surface to capture the analyte(s) therein. In some examples, a material of the body within the recess was subjected to a surface treatment to promote the capture of the analyte(s). In some examples, the oral sampling device includes a flavored substance disposed on at least the portion of the body that is to be received inside of a human mouth. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/547125 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0051 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122584 | Srimathveeravalli et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Govindarajan Srimathveeravalli (Amherst, Massachusetts); Mary Chase Sheehan (Northampton, Massachusetts); Yasushi Kimura (Osaka-fu, Japan); Devan Kumar (Gardner, Massachusetts) |
| ABSTRACT | A device may (i) at least one electrode associated with an electric generator to generate a pulsed electric field (PEF) in solid tissue, wherein said electrode comprises more than one hole/opening at the end in contact with said solid tissue and an insulating sleeve that can be adjusted to alter the side hole profile. A device may (ii) a cellular-component extraction element by suction through at least one electrode, wherein upon introducing said at least one electrode into said solid tissue, and generating the PEF, the PEF induces a biophysical response from cells in solid tissue or other condition (such as be blood, in vitro etc.) resulting in at least one cellular component to exit to extracellular matrix which is then extracted by said extraction element. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/484712 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0266 (20130101) Original (OR) Class A61B 10/0283 (20130101) A61B 2010/0208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122637 | MAZOR et al. |
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| FUNDED BY |
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| APPLICANT(S) | B2M MEDICAL, INC. (Irvine, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafi MAZOR (San Diego, California); Alexei V. Babkin (Dana Point, California) |
| ABSTRACT | A surgical method for reducing insulin resistance comprises cryolipolysis of mesenteric fat in a controlled manner to avoid tissue ablative temperatures. Cryolipolysis is carried out in stages based on evaluating reduction in volumes of mesenteric fat and fasting glucose levels. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485717 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4872 (20130101) A61B 5/14532 (20130101) A61B 18/02 (20130101) Original (OR) Class A61B 2018/0212 (20130101) A61B 2018/0231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122866 | Zhao |
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| FUNDED BY |
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| APPLICANT(S) | Ann and Robert H. Lurie Children's Hospital of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Youyang Zhao (Deerfield, Illinois) |
| ABSTRACT | Disclosed herein is a composition comprising a nanoparticle which comprises polyethylene glycol (PEG)-b-poly (D,L-lactide) (PLA) (PEG-b-PLA) co-polymer formulated with polyethylenimine (PEI) or other cationic polymers and one or more cargo molecules associated with the nanoparticle such as nucleic acids. Also provided are methods for delivering a cargo molecule to a cell in vitro and in vivo using the disclosed compositions. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 18/547669 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122879 | Zhu et al. |
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| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hua Zhu (Columbus, Ohio); Peng Chen (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are methods for treating ocular chemical burns in a subject that involves administering to the cornea of a subject in need thereof a composition comprising a pyroptosis inhibitor, such as disulfiram. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/375697 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/145 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122883 | WHITE et al. |
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| FUNDED BY |
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| APPLICANT(S) | NATIONAL JEWISH HEALTH (Denver, Colorado); SOUTH DAKOTA STATE UNIVERSITY (Brookings, South Dakota); THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl W. WHITE (Denver, Colorado); Heidi NICK (Arvada, Colorado); Preston BRATCHER (Arvada, Colorado); Brian LOGUE (Brookings, South Dakota) |
| ABSTRACT | In one aspect, the present disclosure provides a method of treating a subject exposed to as toxic inhaled chemical, the method comprising administering to the subject a therapeutically effective amount of 2-mercaptoethane sulfonic acid, or a salt or solvate thereof. In some embodiments, the method further comprises administering to the subject a therapeutically effective amount of tissue plasminogen activator. In some embodiments, the toxic inhaled chemical is sulfur mustard, methyl isocyanate, or a combination thereof. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 18/264200 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/185 (20130101) Original (OR) Class A61K 38/49 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122885 | Sirota et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marina Sirota (San Francisco, California); Linda Giudice (San Francisco, California); Arohee Bhoja (San Francisco, California); Daniel Bunis (San Francisco, California) |
| ABSTRACT | Provided are methods of modulating gene expression levels in an individual identified as having endometriosis. The methods comprise administering to the individual identified as having endometriosis a drug described herein in an amount effective to modulate gene expression levels in the individual. Also provided are pharmaceutical compositions. The compositions comprise a drug described herein in an amount effective to modulate gene expression levels in an individual, wherein the pharmaceutical composition is adapted for intrauterine or intravaginal administration of the drug to the individual. Kits that find use in practicing the methods of the present disclosure are also provided. In some embodiments, the kits comprise a pharmaceutical composition comprising a drug described herein in an amount effective to modulate gene expression levels in the individual, and instructions for administering the pharmaceutical composition to an individual identified as having endometriosis. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/276834 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122887 | SNODGRASS |
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| FUNDED BY |
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| APPLICANT(S) | VISTAGEN THERAPEUTICS, INC. (South San Francisco, California) |
| ASSIGNEE(S) | VISTAGEN THERAPEUTICS, INC. (South San Francisco, California) |
| INVENTOR(S) | H. Ralph SNODGRASS (South San Francisco, California) |
| ABSTRACT | Pharmaceutical compositions comprising L-4-chlorokynurenine and associated therapeutic methods are provided for the treatment of certain neurological and other conditions. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/958169 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 25/02 (20180101) A61P 25/18 (20180101) A61P 25/24 (20180101) A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122893 | Brando et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lorraine V. Brando (Baltimore, Maryland); Alvaro A. Ordonez (Baltimore, Maryland); Robert H. Yolken (Baltimore, Maryland); Sanjay K. Jain (Baltimore, Maryland) |
| ABSTRACT | Disclosed herein, are methods for treating, preventing or inhibiting a coronavirus infection or a disease or condition associated with a coronavirus infection. The methods can comprise administering to the subject one or more therapeutically effective doses of sulforaphane. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 18/274560 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/26 (20130101) Original (OR) Class A61K 31/706 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122918 | Steckl et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Steckl (Cincinnati, Ohio); Daewoo Han (Cincinnati, Ohio); Betty M. Tyler (Baltimore, Maryland); Henry Brem (Baltimore, Maryland); Safwan Alomari (Baltimore, Maryland) |
| ABSTRACT | A drug delivery device comprising: a first layer comprising a first coaxially electrospun nanofiber membrane; a second layer comprising a second coaxially electrospun nanofiber membrane; a first therapeutic agent integrated into the first coaxially electrospun nanofiber membrane; and a second therapeutic agent integrated into the second coaxially electrospun nanofiber membrane. The second therapeutic agent is different from the first therapeutic agent. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/380984 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/7007 (20130101) A61K 31/277 (20130101) A61K 31/473 (20130101) Original (OR) Class A61K 31/4188 (20130101) A61K 47/34 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/38 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/022 (20130101) B32B 5/266 (20210501) B32B 37/18 (20130101) B32B 37/1045 (20130101) B32B 38/0004 (20130101) B32B 38/0008 (20130101) B32B 38/18 (20130101) B32B 2250/20 (20130101) B32B 2255/02 (20130101) B32B 2255/26 (20130101) B32B 2262/124 (20210501) B32B 2262/0276 (20130101) B32B 2305/28 (20130101) B32B 2309/02 (20130101) B32B 2310/0843 (20130101) B32B 2367/00 (20130101) B32B 2535/00 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/56 (20130101) D04H 1/435 (20130101) D04H 1/728 (20130101) D04H 1/43828 (20200501) D04H 1/43838 (20200501) Finishing, Dressing, Tentering or Stretching Textile Fabrics D06C 15/00 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2331/30 (20130101) D10B 2331/041 (20130101) D10B 2509/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122922 | Astsaturov et al. |
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| FUNDED BY |
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| APPLICANT(S) | Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor Astsaturov (Philadelphia, Pennsylvania); Edna Cukierman (Philadelphia, Pennsylvania) |
| ABSTRACT | Compositions comprising a TMEM16F inhibitor, an anti-cancer agent, and a pharmaceutically acceptable agent, and methods of treating of cancer comprising administering a TMEM16F inhibitor are provided herein. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/473540 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/426 (20130101) A61K 31/498 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122934 | Davis et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George E. Davis (Tampa, Florida); Gretchen Margaret Koller (Genevieve, Missouri) |
| ABSTRACT | Compositions and methods of treatment for inhibiting capillary tube regression and/or lymphatic tube regression are described, as well as factors and signaling pathways that control the regression of capillary tube networks. Capillary tube regression and/or lymphatic tube regression may be implicated in ischemia, infarction, hypertension, diabetes, malignant cancer, neurodegenerative disease, wound repair response, atherosclerosis, pro-inflammatory disease, pro-thrombotic disease, viral infection (e.g., influenza or SARS-CoV-2), bacterial infection. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/768344 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/352 (20130101) A61K 31/422 (20130101) A61K 31/437 (20130101) A61K 31/506 (20130101) A61K 31/522 (20130101) Original (OR) Class A61K 31/4015 (20130101) A61K 31/4418 (20130101) A61K 31/4439 (20130101) Peptides C07K 16/247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122946 | JAIN |
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| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sushil JAIN (Shreveport, Louisiana) |
| ABSTRACT | A method of treating a cholecalciferol (VD) deficiency associated condition in a patient comprising administering a pharmacologically effective does of a pharmaceutical composition containing VD and one of glutathione (GSH) and a GSH precursor. A pharmaceutical composition for treating a cholecalciferol (VD) deficiency associated condition comprising a pharmacologically effective does of VD and one of glutathione (GSH) and a GSH precursor. |
| FILED | Thursday, January 02, 2020 |
| APPL NO | 16/733113 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/593 (20130101) Original (OR) Class A61K 38/063 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122980 | Kane et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Lawrence Patrick Kane (Pittsburgh, Pennsylvania); Jason Lohmueller (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are chimeric antigen receptors (CARs) that include (a) an extracellular scFv comprising a light chain variable domain (VL) a heavy chain variable domain (VH), wherein the scFv specifically binds to an antigen of interest; (b) a CD8 hinge domain and transmembrane domain; and (c) a cytoplasmic domain comprising (i) a TIM-3 cytoplasmic domain and an intracellular signaling domain, wherein (a)-(c) are in N-terminal to C-terminal order. Also disclosed are nucleic acid molecules encoding these CARs, host cells transformed with these nucleic acids, and the use of these compositions for treating a subject, such as a subject with a tumor. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/769583 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/4631 (20230501) A61K 2239/21 (20230501) A61K 2239/48 (20230501) Peptides C07K 14/70517 (20130101) C07K 16/2887 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122990 | MURRY et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Charles E. MURRY (Seattle, Washington); William Robb MACLELLAN (Seattle, Washington); Robert Scott THIES (Seattle, Washington); Kenta NAKAMURA (Seattle, Washington); Daisy Sue NAKAMURA (Seattle, Washington); Lauren E. NEIDIG (Seattle, Washington) |
| ABSTRACT | The present disclosure provides for the treatment of cardiac diseases and disorders using in vitro-differentiated cardiomyocytes. Such methods can take advantage of both autologous and allogeneic pluripotent stem cells. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/278085 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 35/34 (20130101) Original (OR) Class A61K 38/1774 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122992 | Anker et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan F. Anker (Chicago, Illinois); Praveen Thumblkat (Chicago, Illinois); Sarki A. Abdulkadir (Lombard, Illinois); Anthony J. Schaeffer (Hinsdale, Illinois) |
| ABSTRACT | Provided herein are composition and methods for the treatment of cancer by the administration of uropathogenic bacteria. In particular, CP1 E. coli is administered for the treatment of prostate cancer. |
| FILED | Tuesday, July 11, 2023 |
| APPL NO | 18/350557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class A61K 39/0258 (20130101) A61K 39/001193 (20180801) A61K 39/001194 (20180801) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2039/523 (20130101) A61K 2039/585 (20130101) A61K 2039/884 (20180801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123004 | ZHANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shaun ZHANG (Houston, Texas); Xinping FU (Houston, Texas) |
| ABSTRACT | This invention relates to oncolytic viruses which are more resistant to neutralization and phagocytosis by immune systems, and methods for their preparation and treatment of disorders and diseases (such as cancer) with them. Described herein is an oncolytic Herpes Simplex Virus Type 1 (HSV-1) or Herpes Simplex Virus Type 2 (HSV-2) treated in immune sera that contain a high level of anti-HSV antibodies. In one preferred embodiment, the oncolytic virus includes an extracellular CD47 domain inserted into the N-terminus of a glycoprotein in order to inhibit phagocyte activity. The oncolytic virus is suitable for systemic administration for the treatment of cancer. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 18/264737 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/763 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/70503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16632 (20130101) C12N 2710/16651 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123026 | Matoba et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nobuyuki Matoba (Owensboro, Kentucky); Matthew Dent (Louisville, Kentucky) |
| ABSTRACT | The treatment of ovarian cancers (e.g., epithelial ovarian cancers), which are sensitive to polypeptides comprising an actinohivin or a variant thereof (e.g., AvFc), is described. Methods for killing ovarian cancer cells (e.g, epithelial ovarian cancer cells) are also provided. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 18/277684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/168 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123034 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ModernaTX, Inc. (Cambridge, Massachusetts); BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Yi-Chun Huang (Boston, Massachusetts); Jared Iacovelli (Waltham, Massachusetts); Seymour De Picciotto (Boston, Massachusetts); Sze-Wah Tse (Boston, Massachusetts); Laurie Kenney (Boston, Massachusetts); Katherine Olson (Council Bluffs, Iowa); Howard Gendelman (Omaha, Nebraska); Lee R. Mosley (Omaha, Nebraska) |
| ABSTRACT | The disclosure features lipid nanoparticle (LNP) compositions comprising mRNA molecules encoding human granulocyte macrophage colony stimulating factor (GM-CSF) polypeptides and uses thereof in the treatment of Parkinson's Disease. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding human GM-CSF for use in such treatment. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/768514 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 31/7115 (20130101) A61K 38/193 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123042 | HU |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiwei HU (Dublin, Ohio) |
| ABSTRACT | Disclosed are methods and compositions related to immunoconjugates. Particularly disclosed are immunoconjugates that comprise the Fc portion of IgG3 as well as Factor VII light chain or Factor VII. Also disclosed is an immunoconjugate protein, wherein said immunoconjugate protein comprises a hybrid Fc region of an IgG1 and an IgG3 immunoglobulin conjugated to Factor VII. These immunoconjugates can target Tissue Factor (TF) expressing cells. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529638 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/4846 (20130101) Original (OR) Class Peptides C07K 16/36 (20130101) C07K 2317/72 (20130101) C07K 2317/73 (20130101) C07K 2317/94 (20130101) Enzymes C12Y 304/21021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123046 | SCHIEF et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); FRED HUTCHINSON CANCER RESEARCH CENTER (North Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. SCHIEF (La Jolla, California); Kristen COHEN (North Seattle, Washington); Julie MCELRATH (North Seattle, Washington) |
| ABSTRACT | Provided herein are compositions comprising novel MHC class II T cell epitopes and method using thereof. In some embodiments, a composition described herein comprises an immunogenic polypeptide comprising an MHC class II T cell epitope and a target antigen. In some embodiments, the target antigen is a viral, bacterial, parasite or tumor specific antigen. In some embodiments, the target antigen comprises a virus, bacteria, parasite or tumor specific polypeptide. In some embodiments, the composition comprises a fusion polypeptide comprising the immunogenic polypeptide and the target polypeptide. Also provided are polynucleotides encoding the fusion polypeptide, and methods of administering a composition comprising the polynucleotide to a subject to elicit an immune response. In some embodiments, the polynucleotide is an RNA comprising modified ribonucleotides. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 18/257814 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0208 (20130101) Original (OR) Class A61K 2039/53 (20130101) Peptides C07K 14/005 (20130101) C07K 14/70539 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) Enzymes C12Y 205/01078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123050 | Weissman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); The Johns Hopkins University (Baltimore, Maryland); Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Drew Weissman (Wynnewood, Pennsylvania); George M. Shaw (Wallingford, Pennsylvania); Justin R. Bailey (Timonium, Maryland); Stuart C. Ray (Lutherville, Maryland); James Crowe, Jr. (Nashville, Tennessee); Andrew Flyak (Pasadena, California) |
| ABSTRACT | The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/310066 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 39/29 (20130101) A61K 39/39 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123059 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ting-Ting Wu (Los Angeles, California); Alex Lam (Rosemead, California); Caius Radu (Los Angeles, California) |
| ABSTRACT | Disclosed herein are compositions and methods for inducing and/or enhancing complement-mediated neutralization of a herpesvirus. |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/487526 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/245 (20130101) Original (OR) Class A61K 2039/5258 (20130101) Peptides C07K 16/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123061 | CLARK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington); ABACUS BIOSCIENCE, INC. (Sammamish, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward A. CLARK (Seattle, Washington); Deborah L. FULLER (Seattle, Washington); Che-Leung LAW (Seattle, Washington); Amanda MAK (Seattle, Washington) |
| ABSTRACT | Provided herein are compositions of CD1280 binding proteins and a Hepatitis B virus core antigen (HBcAg) and/or a Hepatitis B virus E antigen (HBeAg), or antigenic fragments or mutants thereof, attached to the CD180 binding protein, and methods for using the compositions to treat or limit the development of hepatitis-B virus (HBV)-related disorders. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/533676 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/292 (20130101) Original (OR) Class A61K 39/001129 (20180801) Peptides C07K 16/2896 (20130101) C07K 2317/56 (20130101) C07K 2317/524 (20130101) C07K 2317/526 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2730/10134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123062 | Libraty |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel H. Libraty (Newton, Massachusetts) |
| ABSTRACT | The present invention relates to the construction of and immunization with viral vaccines. In particular, bivalent vaccines that are capable of providing simultaneous virus infection protection for two or more different viruses. Furthermore, the bivalent vaccines contemplated herein are contemplated as being effective in a neonatal mammal. One such bivalent viral vaccine comprises two antigenic epitopes against the dengue viruses and at least one antigenic epitope against hepatitis B virus. Immunization cross-reactivity may also provide infection protection against other viruses as well. |
| FILED | Thursday, September 21, 2023 |
| APPL NO | 18/471955 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/292 (20130101) A61K 39/295 (20130101) Original (OR) Class A61K 47/65 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123113 | Mentzer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven James Mentzer (Boston, Massachusetts) |
| ABSTRACT | The present disclosure describes bioadhesive polymer composition comprising: a first film comprising a polymer comprising: i) high-methoxyl pectin (HMP) and ii) an initial water content ranging from about 37% to about 43% (w/w); and a second film comprising a polymer comprising: i) HMP and ii) an initial water content ranging from about 9% to about 13% (w/w), wherein the first and second films are adhered to each other. Methods of preparing the bioadhesive polymer compositions and methods of sealing an ocular injury in an eye of a subject are also described. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 18/276540 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/08 (20130101) Original (OR) Class A61L 24/0015 (20130101) A61L 24/0042 (20130101) A61L 2430/16 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 105/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123117 | Leisk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (MEDFORD, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary G. Leisk (Somerville, Massachusetts); Tim Jai-Ching Lo (Lungtan, Taiwan); Lei Li (Beijing, China PRC); Evangelia Bellas (Philadelphia, Pennsylvania); David L. Kaplan (Concord, Massachusetts) |
| ABSTRACT | The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can he injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation. |
| FILED | Tuesday, May 30, 2023 |
| APPL NO | 18/325665 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1767 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/48 (20130101) A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/227 (20130101) Original (OR) Class A61L 27/3604 (20130101) A61L 27/3834 (20130101) A61L 2400/06 (20130101) A61L 2400/08 (20130101) A61L 2430/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123118 | POPAT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ketul C. POPAT (Fort Collins, Colorado); Vignesh KANNIGAIPAIR MANIVASAGAM (Fort Collins, Colorado) |
| ABSTRACT | A titanium superhydrophobic surface comprising a coating of a perfluorosilane on contiguous titania micrograins surrounded by crevices, the micrograins comprising a topography of nanopits shaped by contiguous peaks and valleys. The superhydrophobic surface has significantly increased hemocompatibility and enhanced antibacterial properties compared to an unmodified titanium surface. The increased hemocompatibility was confirmed by reduced platelet adhesion, reduced leukocyte adhesion, and reduced thrombus formation. The surface is prepared by a facile hydrothermal treatment of a titanium surface with sulfuric acid, leading to the formation of a unique micro-nano surface topography. The superhydrophobic surface was then achieved by coating the micro-nano titanium surface with a low energy silane using physical vapor deposition. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/047152 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) A61L 27/306 (20130101) Original (OR) Class A61L 31/10 (20130101) A61L 31/088 (20130101) A61L 2400/12 (20130101) A61L 2400/18 (20130101) A61L 2420/02 (20130101) A61L 2420/04 (20130101) A61L 2420/08 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123122 | WYNNE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WYNNVISION, LLC (Richmond, Virginia) |
| ASSIGNEE(S) | WynnVision, LLC (Richmond, Virginia) |
| INVENTOR(S) | Kenneth J. WYNNE (Midlothian, Virginia); Olga ZOLOTARSKAYA (Richmond, Virginia); Rebecca JARRELL (Williamsburg, Virginia); Kennard BRUNSON (Richmond, Virginia); Chenyu WANG (Midlothian, Virginia) |
| ABSTRACT | A composition, comprising: a physiologically-acceptable polydimethylsiloxane having a surface; and one or more normal C6-C20NR1R2 saturated amine, salt thereof, or combination thereof, in contact with the polydimethylsiloxane, the surface, or both, wherein R1 and R2 may be same or different and independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or combination thereof |
| FILED | Wednesday, May 24, 2023 |
| APPL NO | 18/201709 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/06 (20130101) Original (OR) Class A61L 29/085 (20130101) A61L 31/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123367 | Andrews et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| ASSIGNEE(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| INVENTOR(S) | Robert R. Andrews (Norfolk, Massachusetts); Herman E. Snyder (W. Lafayette, Indiana); William J. Merritt (Danvers, Massachusetts); Evan P. Ordway (Salem, Massachusetts); Clair Strohl (Emmaus, Pennsylvania) |
| ABSTRACT | The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A). |
| FILED | Monday, January 16, 2023 |
| APPL NO | 18/097352 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/00 (20130101) A61J 3/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) A61K 35/16 (20130101) Separation B01D 1/18 (20130101) Original (OR) Class B01D 1/0082 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123368 | Andrews et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| ASSIGNEE(S) | Velico Medical, Inc. (Beverly, Maryland) |
| INVENTOR(S) | Robert R. Andrews (Norfolk, Massachusetts); Herman E. Snyder (W. Lafayette, Indiana); William J. Merritt (Danvers, Massachusetts); Evan P. Ordway (Salem, Massachusetts); Clair Strohl (Emmaus, Pennsylvania); Qiyong Peter Liu (Newton, Massachusetts); Jihae Sohn (Salem, Massachusetts) |
| ABSTRACT | The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A). |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/097822 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/16 (20130101) Original (OR) Class Separation B01D 1/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123447 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Tza-Huei Jeff WANG (Germantown, Maryland); Alexander Y. TRICK (Baltimore, Maryland); Fan-En CHEN (Baltimore, Maryland); Liben CHEN (Ellicott City, Maryland) |
| ABSTRACT | Provided herein are magnetofluidic cartridges of use in a wide variety of sample analysis applications, including nucleic acid amplification assays. The magnetofluidic cartridges include sample inlet wells and sample analysis wells for performing controlled serial elution techniques that enables execution of extraction/purification and splitting of analytes for multiplex detection via magnetic actuation only. Related magnetofluidic devices, kits, and methods are also provided. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 18/263010 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/10 (20130101) B01L 2200/16 (20130101) B01L 2200/027 (20130101) B01L 2200/0647 (20130101) B01L 2200/0689 (20130101) B01L 2300/12 (20130101) B01L 2400/043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54326 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123450 | CAVUTO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IMPERIAL COLLEGE INNOVATIONS LIMITED (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew L. CAVUTO (London, United Kingdom); Ivana PENNISI (London, United Kingdom); Jesus RODRIGUEZ MANZANO (London, United Kingdom); Pantelis GEORGIOU (London, United Kingdom) |
| ABSTRACT | A lid assembly for a sample tube, for collecting magnetic beads from the sample tube and subsequently releasing said beads, the lid assembly comprising: a closure part including means for removably attaching the closure part to the opening of the sample tube, to close the sample tube, and a bead-collecting platform arranged to locate within or above the opening of the sample tube when the closure part is attached to the sample tube, wherein the bead-collecting platform has a bead-collecting surface on one side, for coming into contact with liquid in the sample tube during use, and a magnet-receiving cavity on the other side, behind the bead-collecting surface; and a magnet-bearing part comprising a magnet, wherein the magnet is removably insertable into the magnet-receiving cavity, towards the bead-collecting surface, such that, when the magnet is present within the magnet-receiving cavity, the magnet is capable of holding magnetic beads against the bead-collecting surface, and when the magnet is not present within the magnet-receiving cavity, the lid assembly is incapable of magnetically holding magnetic beads against the bead-collecting surface. Also provided is a method of using such apparatus to collect magnetic beads from a liquid within a sample tube, and associated kits and accessories. |
| FILED | Monday, February 21, 2022 |
| APPL NO | 18/278212 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 1/52 (20190801) B01L 3/50825 (20130101) Original (OR) Class B01L 9/06 (20130101) B01L 2200/0668 (20130101) B01L 2300/047 (20130101) B01L 2300/069 (20130101) B01L 2400/043 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/286 (20130101) B03C 2201/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124392 | Ojima et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| INVENTOR(S) | Iwao Ojima (Port Jefferson, New York); Maurizio Del Poeta (Mount Sinai, New York); Cristina Lazzarini (East Setauket, New York); Krupanandan Haramahalli (Setauket, New York); Yi Sun (Mount Sinai, New York) |
| ABSTRACT | The present invention provides a compound having the structure: and use of the compound for inhibiting the growth of or killing |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530774 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/28 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/195 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) Acyclic or Carbocyclic Compounds C07C 251/86 (20130101) Original (OR) Class Heterocyclic Compounds C07D 213/86 (20130101) C07D 215/54 (20130101) C07D 239/30 (20130101) C07D 307/68 (20130101) C07D 309/08 (20130101) C07D 333/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124395 | Ghosh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Monika Yadav (West Lafayette, Indiana); Andrew Mesecar (West Lafayette, Indiana) |
| ABSTRACT | Inhibitors of SARS-COV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/492411 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/26 (20130101) Original (OR) Class C07D 227/087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124400 | Zhou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Pei Zhou (Durham, North Carolina); Jiyong Hong (Durham, North Carolina) |
| ABSTRACT | LpxH targeting compounds, compositions thereof, as well as methods for for making and using the same are disclosed herein. The LpxH target compounds typically have a structure pursuant to Formula (I) and/or a salt thereof, wherein Rb is selected from a single bond, C4 to C10 unsubstituted aryl, C4 to C10 substituted aryl, unsubstituted or substituted four to ten member heterocycle ring, C1 to C10 unsubstituted alkyl, and C1 to C10 substituted alkyl; Rc comprises hydrogen, halogen, —OH, —CO2CH3, —COOH, —CN2CF3, —CF3, —C2OH, —CONHOH, —CCOH, C4 to C10 unsubstituted aryl, C4 to C10 substituted aryl, unsubstituted or substituted four to ten member heterocycle ring, C1 to C10 unsubstituted alkyl, or C1 to C10 substituted alkyl; and Rd and Re are independently hydrogen, —OH, —COH, —COH, —COC, —COOH, Rf, or are taken together as an unsubstituted or substituted four to eight member nitrogen containing heterocycle ring. |
| FILED | Monday, October 12, 2020 |
| APPL NO | 17/768152 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 311/20 (20130101) Heterocyclic Compounds C07D 209/30 (20130101) Original (OR) Class Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124410 | Lucas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Peter C. Lucas (Pittsburgh, Pennsylvania); Linda M. McAllister (Pittsburgh, Pennsylvania); Heejae Kang (Pittsburgh, Pennsylvania); Beibei Chen (Pittsburgh, Pennsylvania); Lisa Maurer (Pittsburgh, Pennsylvania); Dong Hu (Pittsburgh, Pennsylvania); Jing Cheng (Pittsburgh, Pennsylvania); Linda Klei (Pittsburgh, Pennsylvania); Zaneta Nikolovska-Coleska (Ann Arbor, Michigan) |
| ABSTRACT | Small molecule inhibitors that block the interaction between B-cell lymphoma 10 protein (BCL10) and mucosa- associated lymphoid tissue lymphoma translocation protein 1 (MALT1), thereby inhibiting both the protease and scaffolding activities of MALT1, and MALT1- dependent downstream signaling, including IL-6 and IL-10 secretion by B-cell lymphoma cells and IL-2 transcription and secretion by Jurkat T cells. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/266525 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 317/26 (20130101) Heterocyclic Compounds C07D 209/14 (20130101) C07D 209/38 (20130101) C07D 215/14 (20130101) C07D 235/14 (20130101) C07D 241/42 (20130101) C07D 249/18 (20130101) C07D 263/56 (20130101) C07D 277/64 (20130101) C07D 317/58 (20130101) Original (OR) Class C07D 333/58 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124423 | Beaton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Epigen Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | Epigen Biosciences, Inc. (San Diego, California) |
| INVENTOR(S) | Graham Beaton (Vista, California); Fabio Tucci (San Diego, California); Satheesh Ravula (San Diego, California); Suk Joong Lee (San Diego, California); Chandravadan Shah (San Diego, California) |
| ABSTRACT | Pyrimidine and Pyridine containing compounds are described herein that are enzyme p70S6K inhibitors useful in the treatment of S6K-dependent or S6K-mediated diseases and conditions, including but not limited to cancer, fibrotic metabolic and certain neurological disorders. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/531575 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/04 (20130101) C07D 403/04 (20130101) Original (OR) Class C07D 405/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124462 | HERGENROTHER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Paul J. HERGENROTHER (Champaign, Illinois); Timothy M. FAN (Mahomet, Illinois); Riley L. SVEC (Urbana, Illinois) |
| ABSTRACT | New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067531 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/485 (20130101) A61K 9/2009 (20130101) A61K 9/2013 (20130101) A61K 9/2018 (20130101) A61K 9/2027 (20130101) A61K 9/2054 (20130101) A61K 9/2059 (20130101) A61K 9/4858 (20130101) A61K 9/4866 (20130101) A61K 31/495 (20130101) A61K 47/02 (20130101) A61K 47/24 (20130101) A61K 47/26 (20130101) A61K 47/34 (20130101) A61K 47/36 (20130101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124468 | HOYT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio); The United States of America, as Represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland); KUROME THERAPEUTICS, INC. (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Bryan HOYT (Arlington, Virginia); Craig Joseph THOMAS (Gaithersburg, Maryland); Daniel T. STARCZYNOWSKI (Cincinnati, Ohio); Patrick Joseph SUTTER (Waco, Texas); Gregory James TAWA (Doylestown, Pennsylvania); Chris James FINOCCHIO (Virginia Beach, Virginia); Jan Susan ROSENBAUM (Cincinnati, Ohio); Gabriel GRACIA MALDONADO (Aguadilla, Cyprus) |
| ABSTRACT | Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 18/257746 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 31/635 (20130101) A61K 31/5025 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124520 | BRUNO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Michael BRUNO (Stanford, California); Jijuan GU URBAN (Stanford, California); Jennifer LI-POOK-THAN (Stanford, California); Teri SLIFER (Stanford, California); Michael SNYDER (Stanford, California) |
| ABSTRACT | N-Acylated histidine dipeptides of formula are disclosed. The compounds are useful for treating breast cancer. |
| FILED | Saturday, October 10, 2020 |
| APPL NO | 17/769169 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 5/06147 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124523 | Nguyen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Quyen T. Nguyen (La Jolla, California); Mike Whitney (San Diego, California); Dina Hingorani (San Diego, California); Roger Y. Tsien (Eugene, Oregon); Stephen Adams (Poway, California) |
| ABSTRACT | The present invention provides methods for guiding preservation of human neurons or human nerves during surgery by administering a fluorescently-labeled peptide that specifically binds to the human neurons or human nerves. The invention further provides human neuron or nerve targeting molecules comprising fluorescently-labeled peptides that specifically bind to human neurons or human nerves and compositions thereof. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458690 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 41/0057 (20130101) A61K 45/06 (20130101) A61K 47/64 (20170801) A61K 49/0056 (20130101) Peptides C07K 7/00 (20130101) C07K 7/08 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124526 | Moskal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Joseph R. Moskal (Evanston, Illinois); Jeffrey S. Burgdorf (Evanston, Illinois) |
| ABSTRACT | Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/394401 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) A61P 25/22 (20180101) A61P 25/24 (20180101) Peptides C07K 7/08 (20130101) C07K 7/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124538 | Chen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Lu Chen (Berkeley, California) |
| ABSTRACT | Glaucoma or pathogenic intraocular pressure is treated by locally administering to an eye in need thereof formulations of a Wnt5a inhibitor. |
| FILED | Tuesday, November 28, 2023 |
| APPL NO | 18/522141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 31/335 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) Peptides C07K 7/06 (20130101) C07K 14/4703 (20130101) Original (OR) Class C07K 16/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124539 | ARORA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paramjit S. ARORA (Cold Spring Harbor, New York); Seong Ho HONG (Brooklyn, New York); Daniel YOO (Brooklyn, New York) |
| ABSTRACT | This invention relates to macrostructures (and pharmaceutical formulations containing them) that include an antiparallel coiled-coil. wherein the antiparallel coiled-coil comprises a first coil of Formula I and a second coil of Formula II: T1-g0-a1-b1-c1-d1-e1-f1-g1-a2-b2-c2-d2-e2-f2-g2-a3-b3-c3-d3-e3-f3-T2 (I) T3-f0-g′0-a′1-b′1-c′1-d′1-e′1-f′1-g′1-a′2-b′2-c′2-d′2-e′2-f′2-g′2-a′3-b′3-c′3-d′3-e′3-T4 (II), as described in the present application. Methods of using these macrostructures are also disclosed. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 18/259637 |
| CURRENT CPC | Peptides C07K 14/4705 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124542 | Wagers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amy J. Wagers (Cambridge, Massachusetts); Jill Goldstein (Cambridge, Massachusetts); Ryan G. Walker (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are GDF11 variant polypeptides. Also disclosed herein are methods for increasing GDF11 protein levels in a subject by administering a GDF11 variant polypeptide. |
| FILED | Friday, July 28, 2023 |
| APPL NO | 18/227540 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/51 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124550 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Jianming Wu (Plymouth, Minnesota); Bruce Kenneth Walcheck (Lino Lakes, Minnesota); Robert Harrison Hullsiek (Minneapolis, Minnesota); Yungfang Li (Minneapolis, Minnesota); Hemant Kumar Mishra (Minneapolis, Minnesota) |
| ABSTRACT | A recombinant immune cell expresses a heterologous IgG Fc receptor. In some embodiments, the heterologous IgG Fc receptor can be a chimeric IgG Fc receptor. Generally, the chimeric IgG Fc receptor includes an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain generally includes a sufficient portion of CD64 to bind to an IgG Fc region. The intracellular domain of the chimeric IgG Fc receptor includes a sufficient portion of an Fc receptor allowing immunoreceptor tyrosine-based activation motif (ITAM) to initiate cell signaling when an IgG Fc region binds to the extracellular domain. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/474781 |
| CURRENT CPC | Peptides C07K 14/70535 (20130101) Original (OR) Class C07K 16/30 (20130101) C07K 2317/24 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124552 | Spencer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Michael Spencer (Frisco, Texas); Priyadharshini Narayanan (Houston, Texas) |
| ABSTRACT | Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment. |
| FILED | Friday, April 14, 2023 |
| APPL NO | 18/301164 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/5154 (20130101) Peptides C07K 14/4702 (20130101) C07K 14/4705 (20130101) C07K 14/70578 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) C12N 7/00 (20130101) C12N 9/90 (20130101) C12N 15/86 (20130101) Enzymes C12Y 502/01008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124553 | Diamond et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Michael Diamond (St. Louis, Missouri); Daved Fremont (St. Louis, Missouri); Rong Zhang (St. Louis, Missouri); Arthur Kim (St. Louis, Missouri); Larissa Thackray (St. Louis, Missouri); Katherine Basore (St. Louis, Missouri); Christopher A. Nelson (St. Louis, Missouri); Ofer Zimmerman (St. Louis, Missouri); Maxwell Zimmerman (St. Louis, Missouri); Saravanan Raju (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to compositions and methods of treating arthritogenic alphavirus infection. Compositions include a fusion protein comprising an Fc region, a first Mxra8 region, and a second Mxra8 region, wherein the fusion protein reduces inflammation and infection by an arthritogenic alphavirus. Methods include administering the fusion protein to a mammalian or non-mammalian subject to reduce or inhibit alphavirus infection. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472918 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/70596 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124560 | ZWICK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael ZWICK (La Jolla, California); Lei ZHANG (La Jolla, California); Adriana IRIMIA (La Jolla, California); Jiang ZHU (La Jolla, California); Ian WILSON (La Jolla, California) |
| ABSTRACT | The present disclosure relates to anti-HIV antibodies and their use in the treatment or prevention of HIV/AIDS and in the development of HIV vaccines. |
| FILED | Wednesday, October 14, 2020 |
| APPL NO | 17/768701 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1063 (20130101) Original (OR) Class C07K 2317/31 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56988 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124570 | Vaccari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Miami (Miami, Florida) |
| ASSIGNEE(S) | University of Miami (Miami, Florida) |
| INVENTOR(S) | Juan Pablo De Rivero Vaccari (Miami, Florida); Robert W. Keane (Miami, Florida); W. Dalton Deitrich (Miami, Florida); Helen M. Bramlett (Miami, Florida) |
| ABSTRACT | The compositions and methods described herein include methods and agents that inhibit inflammasome signaling in a mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s) or other agents. Also described herein are compositions and methods of use thereof for detecting and treating early-stage Alzheimer's disease as well as other inflammatory neurologic conditions. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/464174 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) A61K 39/3955 (20130101) A61K 39/39541 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 25/00 (20180101) A61P 25/14 (20180101) A61P 25/28 (20180101) A61P 29/00 (20180101) A61P 37/06 (20180101) Peptides C07K 16/18 (20130101) C07K 16/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124594 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | W.H. Wilson Tang (Cleveland, Ohio); Sathyamangla V. Naga Prasad (Cleveland, Ohio); Maradumane Mohan (Cleveland, Ohio) |
| ABSTRACT | The present invention relates to systems, kits, and methods for treating a subject that has cardiovascular disease or Systemic Sclerosis with at least one of the following: a) IgG3 β1-Adrenergic Receptor antibodies (IgG3 β1AR antibodies), or antigen-binding portion thereof; b) an antigenic protein that elicits the production of IgG3 β1AR antibodies in the subject; or c) a vector comprising a nucleic acid sequence encoding the antigenic protein or IgG3 β1AR antibodies. In certain embodiments, the subject has dilated cardiomyopathy. In some embodiments, the subject is also administered a beta-blocker. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/263929 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/138 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) Peptides C07K 14/001 (20130101) C07K 16/286 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124608 | Hwang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael S. Hwang (Seattle, Washington); Kenneth W. Kinzler (Frankford, Delaware); Brian J. Mog (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Andrew M. Pardoll (Baltimore, Maryland); Suman Paul (Baltimore, Maryland); Bert Vogelstein (Baltimore, Maryland); Shibin Zhou (Owings Mills, Maryland) |
| ABSTRACT | This document relates to methods and materials for treating T cell cancers. For example, a composition containing one or more bispecific molecules targeting T cell receptor £ chain constant region (TRBC) can be administered to a mammal having a T cell cancer to treat the mammal. For example, this document provides methods and materials for using one or more bispecific molecules to treat a mammal having a T cell cancer. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 18/277631 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2809 (20130101) C07K 16/3061 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/73 (20130101) C07K 2317/622 (20130101) C07K 2317/626 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124835 | Zernicka-Goetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Cambridge Enterprise Limited (Cambridge, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Magdalena Zernicka-Goetz (Pasadena, California); Gianluca Amadei (Cambridge, United Kingdom); Charlotte Handford (Cambridge, United Kingdom) |
| ABSTRACT | Disclosed herein include methods, compositions, culture media, and devices for in vitro culture of synthetic embryos from mammalian pluripotent stem cells. The in vitro embryo model is generated with embryonic and extraembryonic lineages derived from embryonic stem cells through transcription-factor-mediated reprogramming and can undergo advanced development to late headfold stages. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/485192 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/06 (20130101) C12M 27/10 (20130101) C12M 29/24 (20130101) C12M 41/34 (20130101) C12M 41/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0604 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2500/32 (20130101) C12N 2500/38 (20130101) C12N 2501/30 (20130101) C12N 2501/115 (20130101) C12N 2501/119 (20130101) C12N 2501/999 (20130101) C12N 2800/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124845 | Hsu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Wei Hsu (Cambridge, Massachusetts); Takamitsu Maruyama (Cambridge, Massachusetts) |
| ABSTRACT | This application relates to stem cell biology and regenerative medicine. Disclosed herein methods for isolation of skeletal stem cells, related methods, related compositions, related products, and related uses. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/547438 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0668 (20130101) Original (OR) Class C12N 2500/25 (20130101) C12N 2501/11 (20130101) C12N 2501/30 (20130101) C12N 2501/115 (20130101) C12N 2509/00 (20130101) C12N 2513/00 (20130101) C12N 2539/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124860 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); David Arthur Scott (Cambridge, Massachusetts); Winston Xia Yan (Cambridge, Massachusetts); Sourav Choudhury (Cambridge, Massachusetts); Matthias Heidenreich (Cambridge, Massachusetts) |
| ABSTRACT | In one aspect, embodiments disclosed herein are directed to engineered CRISPRCas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein that enhances binding of the of the CRISPR complex to the binding site and/or alters editing preference as compared to wild type. In certain example embodiments, the CRISPR-Cas effector protein is a Type II effector protein. In certain other example embodiments, the Type V effector protein is Cas9 or an orthologs or engineered variant thereof. Example Cas9 proteins suitable for use in the embodiments disclosed herein are discussed in further detail below. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488261 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/102 (20130101) C12N 15/1089 (20130101) C12N 2310/20 (20170501) C12N 2710/10343 (20130101) C12N 2740/16043 (20130101) C12N 2750/14143 (20130101) C12N 2800/80 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 30/10 (20190201) G16B 30/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124861 | Sonnenburg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Novome Biotechnologies, Inc. (Daly City, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin L. Sonnenburg (Redwood City, California); Weston R. Whitaker (Daly City, California); Elizabeth Stanley (Portola Valley, California); William C. DeLoache (Oakland, California) |
| ABSTRACT | Compositions and methods are provided for modulating growth of a genetically modified bacterial cell present in a human organ, for modulating growth of a genetically modified bacterial cell in an organ (e.g., gut), for displacing at least a portion of a population of bacterial cells in an organ, and for facilitating gut colonization by a genetically modified bacterial cell. Also provided are genetically modified bacterial cells, e.g., cells that include a heterologous carbohydrate-utilization gene or gene set that provides for the ability to utilize as a carbon source a rare carbohydrate of interest that is utilized as a carbon source by less than 50% of bacterial cells present in a human microbiome. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/391513 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/2402 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/74 (20130101) Enzymes C12Y 302/01178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124863 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Bryan Dickinson (Cambridge, Massachusetts); Michael S. Packer (Cambridge, Massachusetts); Ahmed Hussein Badran (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide methods for phage-assisted continuous evolution (PACE) of proteases. Some aspects of this invention provide methods for evaluating and selecting protease inhibitors based on the likelihood of the emergence of resistant proteases as determined by the protease PACE methods provided herein. Some aspects of this disclosure provide strategies, methods, and reagents for protease PACE, including fusion proteins for translating a desired protease activity into a selective advantage for phage particles encoding a protease exhibiting such an activity and improved mutagenesis-promoting expression constructs. Evolved proteases that recognize target cleavage sites which differ from their canonical cleavage site are also provided herein. |
| FILED | Thursday, August 03, 2023 |
| APPL NO | 18/365105 |
| CURRENT CPC | Peptides C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/50 (20130101) Original (OR) Class C12N 9/1247 (20130101) C12N 15/52 (20130101) C12N 15/62 (20130101) C12N 15/73 (20130101) C12N 15/86 (20130101) C12N 15/1037 (20130101) C12N 15/1058 (20130101) C12N 2795/00022 (20130101) Enzymes C12Y 207/07006 (20130101) C12Y 304/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124866 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Beam Therapeutics Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Beam Therapeutics Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Nicole Marie Gaudelli (Cambridge, Massachusetts); Michael S. Packer (Cambridge, Massachusetts); Gregory Newby (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure provides methods and compositions for treating blood diseases/disorders, such as sickle cell disease, hemochromatosis, hemophilia, and beta-thalassemia. For example the disclosure provides therapeutic guide RNAs that target the promotor of HBG1/2 to generate point mutations that increase expression of fetal hemoglobin. As another example, the disclosure provides therapeutic guide RNAs that target mutations in HBB, Factor VIII, and HFE to treat sickle cell disease, beta-thalassemia, hemophilia and hemochromatosis. The disclosure also provides fusion proteins comprising a Cas9 (e.g., a Cas9 nickase) domain and adenosine deaminases that deaminate adenosine in DNA. In some embodiments, the fusion proteins are in complex with nucleic acids, such as guide RNAs (gRNAs), which target the fusion proteins to a DNA sequence (e.g., an HBG1 or HBG2 protmoter sequence, or an HFE, GBB, or F8 gene sequence). Such complexes may be useful for increasing expression of fetal hemoglobin or correcting a poing mutation (e.g., C282Y) in HFE. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/460178 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124870 | Mello et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig Cameron Mello (Barrington, Rhode Island); Krishna Sumanth Ghanta (Grafton, Massachusetts); Gregoriy Dokshin (Belmont, Massachusetts); Aamir Mir (Worcester, Massachusetts); Hassan Gneid (Worcester, Massachusetts); Jonathan Kenneth Watts (Worcester, Massachusetts); Erik Joseph Sontheimer (Auburndale, Massachusetts) |
| ABSTRACT | The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing. |
| FILED | Friday, June 09, 2023 |
| APPL NO | 18/332029 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/66 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 15/902 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124873 | Sanjana et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York Genome Center, Inc. (New York, New York); New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neville E. Sanjana (New York, New York); Hans-Hermann Wessels (Brooklyn, New York); Alejandro Mendez-Mancilla (Brooklyn, New York); Rahul Satija (New York, New York) |
| ABSTRACT | Provided herein are compositions comprising a CRISPR array comprising one or more crRNA sequences and a 5′ direct repeat (DR) sequence linked to a barcode guide RNA (bcgRNA), wherein the bcgRNA comprises from 5′ to 3′ (a) a barcode sequence, and (b) a reverse-transcription handle. Also provided are methods that comprise using the described CRISPR arrays to introduce one or perturbations in a single cell transcriptome. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 18/547814 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 15/1065 (20130101) C12N 2310/20 (20170501) C12N 2310/3517 (20130101) C12N 2310/3519 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124877 | Weiss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ron Weiss (Newton, Massachusetts); Breanna E. DiAndreth (Newbury Park, California) |
| ABSTRACT | Provided herein are genetic circuits and encoded RNA transcripts that produce an output molecule in response to an RNA cleavage event that removes a degradation signal. In some embodiments, the genetic circuits described herein may be used for detecting RNA cleaver activities (e.g., in a cell). Methods of using the genetic circuits described herein in diagnostic or therapeutic applications are also provided. |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/466891 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/67 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/121 (20130101) C12N 2310/122 (20130101) C12N 2310/126 (20130101) C12N 2840/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124878 | Asokan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravind Asokan (Durham, North Carolina); David Fiflis (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are compositions for and methods of generating chimeric RNA molecules and methods of treating and/or preventing a genetic disease or disorder using chimeric RNA molecules. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 18/547688 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124895 | Dever et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Daniel P. Dever (Stanford, California); Rasmus O. Bak (Stanford, California); Ayal Hendel (Stanford, California); Waracharee Srifa (Stanford, California); Matthew H. Porteus (Stanford, California) |
| ABSTRACT | In certain aspects, the present invention provides methods for inducing a stable gene modification of a target nucleic acid via homologous recombination in a primary cell, such as a primary blood cell and/or a primary mesenchymal cell. In certain other aspects, the present invention provides methods for enriching a population of genetically modified primary cells having targeted integration at a target nucleic acid. The methods of the present invention rely on the introduction of a DNA nuclease such as a Cas polypeptide and a homologous donor adeno-associated viral (AAV) vector into the primary cell to mediate targeted integration of the target nucleic acid. Also provided herein are methods for preventing or treating a disease in a subject in need thereof by administering to the subject any of the genetically modified primary cells or pharmaceutical compositions described herein to prevent the disease or ameliorate one or more symptoms of the disease. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/074781 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7115 (20130101) A61K 35/28 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) Peptides C07K 14/805 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) C12N 5/0636 (20130101) C12N 5/0647 (20130101) C12N 5/0665 (20130101) C12N 9/22 (20130101) C12N 15/85 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/8645 (20130101) C12N 2310/20 (20170501) C12N 2310/311 (20130101) C12N 2310/313 (20130101) C12N 2310/3125 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124913 | Lu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew C. Lu (Pasadena, Ukraine); Michael J. Flynn (Pasadena, California); Lucy S. Chong (Pasadena, California); Ronghui Zhu (Pasadena, California); Michael B. Elowitz (Pasadena, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in signal amplification. There are provided, in some embodiments, protease-based signal amplification modules. Disclosed herein include amplifier proteins comprising a first part of a first protease domain, a first dimerization domain, a first cut site a protease in a protease active state is capable of cutting, a second dimerization domain, a second cut site a protease in a protease active state is capable of cutting, and a first caging domain. Disclosed herein include companion amplifier proteins comprising a second part of a first protease domain, a third dimerization domain, a third cut site a protease in a protease active state is capable of cutting, a fourth dimerization domain, a fourth cut site a protease in a protease active state is capable of cutting, and a second caging domain. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/486875 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/4873 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124928 | Gundlach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); The UAB Research Foundation (Birmingham, Alabama) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington); The UAB Research Foundation (Birmingham, Alabama) |
| INVENTOR(S) | Jens H. Gundlach (Seattle, Washington); Michael Niederweis (Homewood, Alabama); Thomas Z. Butler (Seattle, Washington); Mikhail Pavlenok (Birmingham, Alabama); Mark A. Troll (Seattle, Washington); Suja Sukumaran (Dublin, California) |
| ABSTRACT | Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression. |
| FILED | Monday, April 24, 2023 |
| APPL NO | 18/305770 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/04 (20130101) Peptides C07K 14/35 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44704 (20130101) G01N 27/44791 (20130101) G01N 33/6872 (20130101) G01N 33/48721 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124932 | Daugharthy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan R. Daugharthy (Cambridge, Massachusetts); George M. Church (Brookline, Massachusetts) |
| ABSTRACT | The disclosure provides a method for detecting a target analyte in a biological sample including contacting the sample with one or more probe sets each comprising a primary probe and a linker, contacting the sample with an initiator sequence, contacting the sample with a plurality of fluorescent DNA hairpins, wherein the probe binds the target molecule, the linker connects the probe to the initiator sequence, and wherein the initiator sequence nucleates with the cognate hairpin and triggers self-assembly of tethered fluorescent amplification polymers, and detecting the target molecule by measuring fluorescent signal of the sample. |
| FILED | Monday, June 12, 2023 |
| APPL NO | 18/332933 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 2310/16 (20130101) C12N 2320/10 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6806 (20130101) C12Q 1/6816 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124935 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Yong-Chen Lu (Little Rock, Arkansas); Peter Fitzgerald (Silver Spring, Maryland); Zhili Zheng (Gaithersburg, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed are methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences, or an antigen-binding portion thereof. Also disclosed are methods of automatically identifying the TCR alpha and beta chain V segment sequences and CDR3 sequences of a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Methods of preparing a population of cells that express paired TCR alpha and beta chain sequences, or an antigen-binding portion thereof, are also disclosed. Isolated pairs of TCR alpha and beta chain sequences and isolated populations of cells prepared by the methods are also disclosed. |
| FILED | Wednesday, December 27, 2023 |
| APPL NO | 18/397448 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/7051 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/1003 (20130101) C12N 15/1096 (20130101) C12N 2502/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) G16B 30/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125551 | Erickson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| ASSIGNEE(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| INVENTOR(S) | Kyle D. Erickson (Melrose, Massachusetts); William J. Merritt (Danvers, Maine) |
| ABSTRACT | The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port. |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/467130 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/16 (20130101) Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 3/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125728 | Ahmad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mohammad Ahmad (Syracuse, New York); Liviu Movileanu (Syracuse, New York) |
| ASSIGNEE(S) | SYRACUSE UNIVERSITY (Syracuse, New York) |
| INVENTOR(S) | Mohammad Ahmad (Syracuse, New York); Liviu Movileanu (Syracuse, New York) |
| ABSTRACT | A new class of sensing elements made of a protein pore fused to a programmable antibody-mimetic binder. This modular design expands the utility of nanopore sensors to numerous proteins while preserving their architecture, specificity, and sensitivity. The sensing elements were validated with protein analytes that drastically vary in size, charge, and structural complexity. These analytes produce unique electrical signatures that depend on their identity and quantity and the binder-analyte assembly at the nanopore tip. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/372852 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3276 (20130101) Original (OR) Class G01N 33/5438 (20130101) G01N 33/6803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125764 | Sohn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lydia Lee Sohn (Oakland, California); David V. Schaffer (Danville, California); Olivia J. Scheideler (Berkeley, California); Connor Andrew Tsuchida (Berkeley, California) |
| ABSTRACT | The present disclosure provides a composition comprising a solid support, a plurality of tethered oligonucleotides attached to the solid support, and a plurality of untethered oligonucleotides hybridized to the tethered oligonucleotides. An untethered oligonucleotide can comprise, attached via the 5′ end, a cell, or an effector molecule. Hybridization of an untethered oligonucleotide to a tethered oligonucleotide generates an enzyme cleavage site, which allows for temporally controlled removal of an effector molecule. The present disclosure provides methods of temporally modulating the activity and/or phenotype of a cell. The present disclosure provides a solid support comprising patterned tethered oligonucleotides attached thereto; and methods of making the solid support. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/768700 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125783 | Guttman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mitchell Guttman (Los Angeles, California); Mario R. Blanco (Los Angeles, California); Ward Walkup, IV (Lincoln, Massachusetts) |
| ABSTRACT | In some embodiments, methods of detecting an association between a query protein and a target moiety are described. In some embodiments, compositions are described. In some embodiments, kits are described. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491255 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/907 (20130101) Enzymes C12Y 201/01043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125787 | Barbie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | David Barbie (Andover, Massachusetts); Israel Cañadas (Brookline, Massachusetts); Shunsuke Kitajima (Allston, Massachusetts); Thanh Barbie (Andover, Massachusetts) |
| ABSTRACT | Provided herein are STING and SPARCS genes as biomarkers for determining an effective therapy for treating cancer. Further provided are methods for treating cancer using said biomarkers. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/530114 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/005 (20130101) A61K 38/21 (20130101) A61K 38/217 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/57 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6866 (20130101) G01N 33/57423 (20130101) G01N 33/57484 (20130101) Original (OR) Class G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125793 | Birnbaum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (PASADENA, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Edward Birnbaum (Stanford, California); Juan Luis Mendoza (Redwood City, California); Michael Thomas Bethune (Pasadena, California); David Baltimore (Pasadena, California); Kenan Christopher Garcia (Menlo Park, California) |
| ABSTRACT | Compositions and methods are provided for the identification of peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/493253 |
| CURRENT CPC | Peptides C07K 14/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) Original (OR) Class G01N 2333/7051 (20130101) G01N 2333/70539 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125797 | Greenleaf et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CZ Biohub SF, LL (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William J. Greenleaf (Stanford, California); Amy F. Chen (Stanford, California) |
| ABSTRACT | The invention provides compositions and methods for quantifying cellular molecules of interest, e.g., intracellular proteins, using oligonucleotide-target binding moiety conjugates. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 18/262519 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125948 | Cates et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Joshua W. Cates (San Francisco, California); Woon-Seng Choong (Oakland, California); Erik Brubaker (Oakland, California) |
| ABSTRACT | A single photon radiation detector is designed for a particular radiation source fluence, such that an incident radiation photon strikes a scintillator monolith, creating scintillation photons, which are amplified by appropriately sized channels of photomultipliers optically coupled to the scintillator monolith. The photomultiplier output is electronically shaped into a corresponding stream of scintillation pulses (otherwise referred to as scintillation photons) that pass through a comparator to produce a bitstream of the detected scintillation photons, which is sampled into a field programmable gate array (FPGA) acting as a giga-sample transceiver to produce time-to-digital conversions, capable of producing an output data stream of 10's-of-giga-samples per second or more. Appropriate design ensures sparsity of scintillation photon arrival, so that each photon in the bitstream corresponds to a single incident scintillation photon. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/486026 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/248 (20130101) G01T 1/20184 (20200501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127050 | LU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qing LU (Gainesville, Florida); Xiaoxi SHEN (Gainesville, Florida); Tingting HOU (Gainesville, Florida) |
| ABSTRACT | Various examples are provided related to the application of a kernel neural network (KNN) to the analysis of high dimensional and ultrahigh dimensional data for, e.g., risk prediction. In one embodiment, a method includes training a KNN with a training set to produce a trained KNN model, determining a likelihood of a condition based at least in part upon an output indication of the trained KNN corresponding to one or more phenotypes, identifying treatment or prevention strategy for an individual based at least in part upon the likelihood of the condition. The KNN model includes a plurality of kernels as a plurality of layers to capture complexity between the data with disease phenotypes. The training set of data includes genetic information applied as inputs to the KNN and the phenotype(s), and the output indication is based upon analysis of data comprising genetic information from the individual by the trained KNN. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 18/267184 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 5/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127447 | CONKLIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. CONKLIN (Philadelphia, Pennsylvania); Feroze B. MOHAMED (Philadelphia, Pennsylvania); Devon M. MIDDLETON (Philadelphia, Pennsylvania); Mahdi ALIZADEH (Philadelphia, Pennsylvania) |
| ABSTRACT | A method of generating a quantitative characterization of injury presence and status of spinal cord tissue using an adaptive CNN system for use in diagnostic assessment, surgical planning, and therapeutic strategy comprises preprocessing for artifact correction of diffusion based, spinal cord MM data, training an adaptive CNN system with healthy and abnormal (injured/pathologic) spinal cord images obtained by imaging a population of healthy, typically developed spinal cord subjects and subjects with spinal cord injury, evaluating a novel, diffusion-based MM image for injury biomarkers using the adaptive CNN system, generating a three-dimensional predictive axonal damage map for quantitative characterization and visualization of the novel, diffusion-based MM image, and transmitting the sets of healthy and injured spinal cord images back to a central database for continued improvement of the adaptive CNN system training. A system for defining a predictive spinal axonal damage map is also described. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530829 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4566 (20130101) A61B 5/7214 (20130101) A61B 5/7267 (20130101) A61B 34/10 (20160201) A61B 2034/105 (20160201) Image Data Processing or Generation, in General G06T 7/0014 (20130101) Original (OR) Class G06T 7/136 (20170101) G06T 7/155 (20170101) G06T 7/187 (20170101) G06T 11/005 (20130101) G06T 2207/10092 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30012 (20130101) G06T 2211/424 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127910 | Clancy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Colleen Clancy (Davis, California); Pei-Chi Yang (Davis, California); Kevin DeMarco (Davis, California); Igor V. Vorobyov (Davis, California) |
| ABSTRACT | The disclosure presents a new computer based model framework to predict drug effects over multiple time and spatial scales from the drug chemistry to the cardiac rhythm. The disclosure presents a new computer based model framework to predict drug effects from the level of the receptor interaction to the cardiac rhythm. |
| FILED | Thursday, June 01, 2023 |
| APPL NO | 18/204912 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/30 (20190201) G16C 20/50 (20190201) Original (OR) Class G16C 20/70 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127967 | White et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); Fred Hutchinson Cancer Research Center (Seatlle, Washington); Stephen , J. , Polyak (Seattle, Washington); Lisa , Johansen (Belmont, Massachusetts) |
| ASSIGNEE(S) | Stephen J. Polyak (Seattle, Washington); Lisa Johansen (Belmont, Massachusetts); University of Virginia Patent Foundation (Charlottesville, Virginia); Fred Hutchinson Cancer Research Center (Seatlle, Washington) |
| INVENTOR(S) | Judith M. White (Charlottesville, Virginia); Shuang Xu (Redmond, Washington); Joshua T. Schiffer (Seattle, Washington); Gene G. Olinger (Frederick, Maryland); Courtney L. Finch (Orrtanna, Pennsylvania); Julie Dyall (Washington, District of Columbia); Stephen J. Polyak (Seattle, Washington); Lisa Johansen (Belmont, Massachusetts) |
| ABSTRACT | Methods of modeling the in vivo efficacy of drug combinations for the treatment or prevention of viral infection are described. The described methods combine data for single drugs and drug combinations from pharmacokinetic, pharmacodynamic, and viral dynamics models under a series of estimated in vivo drug potencies to provide predictions of the in vivo effects of the drug combinations. These predictions can be used to more accurately select drugs and drug treatment regimens that can be successful in controlling viral infection in animal studies, clinical trials and in medical or veterinary interventions. Also described is a method of treating or preventing filovirus infections using combinations of orally available drugs based on predictions from the modeling methods. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 18/276599 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/138 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101) G16H 70/40 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240122473 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Juejun Hu (Newton, Massachusetts); Tian GU (Fairfax, Virginia); Mikhail Shalaginov (Somerville, Massachusetts); Fan YANG (Cambridge, Massachusetts) |
| ABSTRACT | Meta-lens based ocular imaging, near-eye display, and eye-tracking systems are described. The systems can include a single focusing optic and an integrated circuit that provides illumination light and includes an imaging array. The focusing optic includes meta-atoms formed on a substrate. The systems may have no moving parts and achieve imaging or image-projection fields-of-view approaching or exceeding 180 degrees. Because of their low part count, the systems can be robust and have a very small form factor. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/540256 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/14 (20130101) Original (OR) Class A61B 3/113 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 27/0093 (20130101) G02B 27/0172 (20130101) Electric Digital Data Processing G06F 3/013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122584 | Srimathveeravalli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Govindarajan Srimathveeravalli (Amherst, Massachusetts); Mary Chase Sheehan (Northampton, Massachusetts); Yasushi Kimura (Osaka-fu, Japan); Devan Kumar (Gardner, Massachusetts) |
| ABSTRACT | A device may (i) at least one electrode associated with an electric generator to generate a pulsed electric field (PEF) in solid tissue, wherein said electrode comprises more than one hole/opening at the end in contact with said solid tissue and an insulating sleeve that can be adjusted to alter the side hole profile. A device may (ii) a cellular-component extraction element by suction through at least one electrode, wherein upon introducing said at least one electrode into said solid tissue, and generating the PEF, the PEF induces a biophysical response from cells in solid tissue or other condition (such as be blood, in vitro etc.) resulting in at least one cellular component to exit to extracellular matrix which is then extracted by said extraction element. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/484712 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0266 (20130101) Original (OR) Class A61B 10/0283 (20130101) A61B 2010/0208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122861 | Raghavan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivasa R. Raghavan (Columbia, Maryland); Ankit Gargava (Hillsboro, Oregon); Wenhao Xu (College Park, Maryland) |
| ABSTRACT | Surprisingly, electric fields can induce a dramatic response in soft materials made from nonconducting biopolymers. Capsules made from Alginate, Chitosan, and Gellan gum, all of which are charged polysaccharides and are biocompatible and biodegradable. Each capsule is formed by crosslinking biopolymer chains via physical (ionic/electrostatic) interactions. Under a DC electric field, the capsules rupture and disintegrate in a span of less than five minutes. The mechanism for the electroresponse is attributed to electrophoretic rearrangement of ions and/or polyelectrolyte chains in the capsule. Alginate capsules first swell anisotropically on their side closer to the anode (+ electrode). Cations migrate away from the anode, thereby lowering the crosslink density on that side. As further crosslinks are lost from the anode side, the capsule eventually breaks. A valve design utilizes an orifice that is blocked by a capsule and the valve is opened when the capsule is dislodged by the field. |
| FILED | Wednesday, October 18, 2023 |
| APPL NO | 18/489408 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 9/4816 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 47/20 (20130101) A61K 47/36 (20130101) A61K 49/0047 (20130101) A61K 49/0054 (20130101) A61K 49/0093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122876 | Tochtrop et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Tochtrop (Cleveland, Ohio); Philip Kiser (Cleveland, Ohio); Jianye Zhang (Cleveland, Ohio); Krzysztof Palczewski (Oakland, California) |
| ABSTRACT | A method of treating an ocular disorder in a subject in need thereof includes administering to the subject a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, tautomer, or solvate thereof. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 18/263758 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122987 | CAP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew P. CAP (Hollywood Park, Texas); James A. BYNUM (La Vernia, Texas); Xiaowu WU (San Antonio, Texas) |
| ABSTRACT | A majority of military casualties occur during the pre-hospital period. The cause of death is largely associated with massive traumatic bleeding that leads to organ damage due to sustained hypoxia. Currently, therapeutics are lacking at the point of injury to mitigate hypoxic damage and maintain the survivability of severe hemorrhage prior to reaching medical facilities. This invention addresses that by introducing a method of co-administering prolyl hydroxylase domain inhibitor (PHDi, MK-8617), anti-fibrinolytic agent (tranexamic acid), and bradykinin receptor antagonist (icatibant) as anti-hemorrhage agents in combination with resuscitation fluid treatment with colloid solution of 25% human albumin that has an advantage of relatively small volume requirement to maintain blood volume. In addition, a kit comprising anti-hemorrhage agents that can be easily carried to the battlefield is also provided here. The therapeutic application of those agents on or near the point of injury can stabilize hypoxia inducible factor-1 alpha and enhance blood clot formation, which improves the patient's cellular adaptation to hypoxia and reduce hemorrhage, and thus can decrease organ failure and increase the patient's survivability. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/379740 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/137 (20130101) A61K 31/437 (20130101) A61K 31/472 (20130101) A61K 31/506 (20130101) A61K 31/513 (20130101) A61K 31/4418 (20130101) A61K 31/5377 (20130101) A61K 35/14 (20130101) A61K 35/16 (20130101) A61K 35/18 (20130101) A61K 35/19 (20130101) Original (OR) Class A61K 38/38 (20130101) A61K 38/043 (20130101) A61K 38/095 (20190101) A61K 38/363 (20130101) A61K 47/26 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123032 | Chauhan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunil Chauhan (Cambridge, Massachusetts); Reza Dana (Newton, Massachusetts) |
| ABSTRACT | This application discloses ophthalmic formulations and methods for treating and preventing corneal haze and scarring with an hepatocyte growth factor (HGF) agent. |
| FILED | Thursday, June 01, 2023 |
| APPL NO | 18/327544 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/1833 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/00 (20130101) C07K 14/4753 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123075 | JIANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Shaoyi JIANG (Redmond, Washington); Priyesh JAIN (Seattle, Washington); Jinrong MA (Seattle, Washington); Bowen Li (Seattle, Washington) |
| ABSTRACT | N-oxide and monomers, N-oxide polymers and copolymers, methods for making the N-oxide monomers, polymers, and copolymers, compositions and materials that include N-oxide polymers and copolymers, and methods for using the N-oxide monomers, N-oxide polymers, and N-oxide copolymers. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356932 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5138 (20130101) A61K 47/58 (20170801) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/34 (20130101) A61L 29/085 (20130101) A61L 31/10 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/60 (20130101) C08F 220/603 (20200201) C08F 222/225 (20200201) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 2300/206 (20130101) C08J 2333/26 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123117 | Leisk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (MEDFORD, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary G. Leisk (Somerville, Massachusetts); Tim Jai-Ching Lo (Lungtan, Taiwan); Lei Li (Beijing, China PRC); Evangelia Bellas (Philadelphia, Pennsylvania); David L. Kaplan (Concord, Massachusetts) |
| ABSTRACT | The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can he injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation. |
| FILED | Tuesday, May 30, 2023 |
| APPL NO | 18/325665 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1767 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/48 (20130101) A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/227 (20130101) Original (OR) Class A61L 27/3604 (20130101) A61L 27/3834 (20130101) A61L 2400/06 (20130101) A61L 2400/08 (20130101) A61L 2430/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123437 | DIESENDRUCK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Technion Research and Development Foundation Limited (Haifa, Israel) |
| ASSIGNEE(S) | Technion Research and Development Foundation Limited (Haifa, Israel) |
| INVENTOR(S) | Charles Eliezer DIESENDRUCK (Haifa, Israel); Dario R. DEKEL (Haifa, Israel) |
| ABSTRACT | Polymeric ion conductors composed of a polymeric matrix associated with an isoindolinium moiety represented by Formula I as described in the specification are provided. Anion conducting compositions comprising an anion conducting polymer associated with, or threaded within and having mechanically interlocked therearound, a cyclic moiety are also provided. lonomeric materials, including, for example, ion exchange membranes such as anion exchange membranes, made of the polymeric ion conductor and/or the anion conducting composition, and electrochemical systems and articles-of-manufacturing containing the polymeric ion conductor, the anion conducting composition or the ion exchange membrane are also provided. |
| FILED | Friday, December 31, 2021 |
| APPL NO | 18/269974 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/05 (20170101) B01J 41/14 (20130101) Original (OR) Class B01J 47/12 (20130101) Heterocyclic Compounds C07D 209/44 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 212/08 (20130101) C08F 2800/10 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2231 (20130101) C08J 5/2243 (20130101) C08J 2323/06 (20130101) C08J 2325/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/083 (20130101) H01M 8/103 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123497 | Agarwal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida International University Board of Trustees (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arvind Agarwal (Miami, Florida); Cheng Zhang (Miami, Florida); Tanaji Paul (Miami, Florida); Sohail Mazher Ali Khan Mohammed (Miami, Florida); Denny John (Miami, Florida) |
| ABSTRACT | Methods for large-scale additive manufacturing of high-strength boron nitride nanotubes (BNNT)/aluminum (Al) (e.g., reinforced Al alloy) metal matrix composites (MMCs) (BNNT/Al MMCs), as well as the BNNT/Al MMCs produced by the large-scale additive manufacturing methods, are provided. A combination of ultrasonication and spray drying techniques can produce good BNNT/Al alloy feedstock powders, which can be used in a cold spraying process. |
| FILED | Thursday, April 06, 2023 |
| APPL NO | 18/296572 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/103 (20220101) B22F 1/0547 (20220101) Original (OR) Class B22F 10/64 (20210101) B22F 2301/052 (20130101) B22F 2302/205 (20130101) B22F 2304/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Alloys C22C 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123550 | Hoye et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Earl Hoye (Columbus, Indiana); Sameehan Shrikant Joshi (Dallas, Texas); Howard S. Savage (Columbus, Indiana) |
| ABSTRACT | A piston for a reciprocating piston engine includes a piston body including a piston form and a superalloy overlay cladding and metallurgically bonded with a portion of the piston form. The superalloy overlay includes a first weld layer disposed on the piston form which includes a first plurality of adjoining weld beads. The superalloy overlay further includes a second weld layer disposed on the first weld layer which includes a second plurality of adjoining weld beads. |
| FILED | Thursday, May 18, 2023 |
| APPL NO | 18/319528 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/34 (20130101) Original (OR) Class B23K 2101/003 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124304 | Becker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carol A. Becker (Del Mar, California); Wayne E. Glad (Del Mar, California) |
| ABSTRACT | An apparatus and method generate oxygen gas from sodium percarbonate and water including seawater. The apparatus includes a chamber, a valve system, and an output port. The valve system controls combining a quantity of the sodium percarbonate, a quantity of the water, a quantity of potassium iodide, and optionally a quantity of sodium sulfate decahydrate. A chemical reaction between the sodium percarbonate and the water in the chamber generates oxygen gas, which is output at an output port from the chamber. The potassium iodide is a catalyst for the chemical reaction and optionally the sodium sulfate decahydrate is a temperature moderator for the chemical reaction. A ratio between the water and the sodium percarbonate is in a range of 2.5 to 8 by weight. A ratio of the potassium iodide per liter of the water yields a molarity in a range of 0.25 to 1.25. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495446 |
| CURRENT CPC | Devices, Apparatus or Methods for Life-saving A62B 7/08 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/0278 (20130101) B01J 2208/00752 (20130101) Non-metallic Elements; Compounds Thereof; C01B 13/0207 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124356 | Plattenberger |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oldcastle APG, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan Austin Plattenberger (Denver, Colorado) |
| ABSTRACT | A formulation for a packaged, dry, cementitious concrete material for rapid repairs to hardened hydraulic-cement concrete pavements, structures, and other articles meets or exceeds the performance requirements of ASTM C928/C928M—20a for a type R3 concrete to be mixed and applied at or below 32° F. The formulation includes calcium sulfoaluminate cement; and a hardening accelerator that operates by contributing seeds of calcium-silicate-hydrate when the dry cementitious concrete material is mixed with water. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/375776 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 24/06 (20130101) C04B 28/065 (20130101) Original (OR) Class C04B 40/0042 (20130101) C04B 2103/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124652 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loon-Seng Tan (Centerville, Ohio); Zhenning Yu (Beavercreek, Ohio); Bingqian Zheng (Miamisburg, Ohio); Hilmar Koerner (Beavercreek, Ohio) |
| ABSTRACT | A family of low-molecular-weight, main-chain thermotropic liquid-crystalline polyimides (TLC-PI) that are crosslinkable is disclosed. These all-aromatic TLC-PI are derived from (i) wholly aromatic and flexible diamine monomers, in which the linkage between the two aniline-ends contains a relatively high heat-tolerant but flexible chain constituted by two or more units of 1,4-phenoxy or 1,3-phenoxy or in combinations of both. Processes of making and using such all-aromatic TLC-PI is also provided. |
| FILED | Wednesday, April 12, 2023 |
| APPL NO | 18/299353 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/1032 (20130101) C08G 73/1071 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124667 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Guang-lin Zhao (Baton Rouge, Louisiana); Rong Zhao (Huaibel in Anhui province, China PRC) |
| ASSIGNEE(S) | Southern University and A and M College (, None) |
| INVENTOR(S) | Guang-lin Zhao (Baton Rouge, Louisiana); Rong Zhao (Huaibel in Anhui province, China PRC) |
| ABSTRACT | A process for forming multifunctional carbon nanotubes-glass fiber-epoxy composites with high density interfaces for microwave absorption and structural materials application useful as a multifunctional microwave absorption and low-weight structural material without a need of additional coating. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 17/965722 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 7/22 (20130101) B29B 7/88 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/003 (20210501) B29C 70/22 (20130101) B29C 70/30 (20130101) B29C 70/081 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/244 (20210501) C08J 5/249 (20210501) Original (OR) Class C08J 2363/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) C08K 2201/003 (20130101) C08K 2201/004 (20130101) C08K 2201/011 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 9/009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124863 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Bryan Dickinson (Cambridge, Massachusetts); Michael S. Packer (Cambridge, Massachusetts); Ahmed Hussein Badran (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide methods for phage-assisted continuous evolution (PACE) of proteases. Some aspects of this invention provide methods for evaluating and selecting protease inhibitors based on the likelihood of the emergence of resistant proteases as determined by the protease PACE methods provided herein. Some aspects of this disclosure provide strategies, methods, and reagents for protease PACE, including fusion proteins for translating a desired protease activity into a selective advantage for phage particles encoding a protease exhibiting such an activity and improved mutagenesis-promoting expression constructs. Evolved proteases that recognize target cleavage sites which differ from their canonical cleavage site are also provided herein. |
| FILED | Thursday, August 03, 2023 |
| APPL NO | 18/365105 |
| CURRENT CPC | Peptides C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/50 (20130101) Original (OR) Class C12N 9/1247 (20130101) C12N 15/52 (20130101) C12N 15/62 (20130101) C12N 15/73 (20130101) C12N 15/86 (20130101) C12N 15/1037 (20130101) C12N 15/1058 (20130101) C12N 2795/00022 (20130101) Enzymes C12Y 207/07006 (20130101) C12Y 304/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124866 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Beam Therapeutics Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Beam Therapeutics Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Nicole Marie Gaudelli (Cambridge, Massachusetts); Michael S. Packer (Cambridge, Massachusetts); Gregory Newby (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure provides methods and compositions for treating blood diseases/disorders, such as sickle cell disease, hemochromatosis, hemophilia, and beta-thalassemia. For example the disclosure provides therapeutic guide RNAs that target the promotor of HBG1/2 to generate point mutations that increase expression of fetal hemoglobin. As another example, the disclosure provides therapeutic guide RNAs that target mutations in HBB, Factor VIII, and HFE to treat sickle cell disease, beta-thalassemia, hemophilia and hemochromatosis. The disclosure also provides fusion proteins comprising a Cas9 (e.g., a Cas9 nickase) domain and adenosine deaminases that deaminate adenosine in DNA. In some embodiments, the fusion proteins are in complex with nucleic acids, such as guide RNAs (gRNAs), which target the fusion proteins to a DNA sequence (e.g., an HBG1 or HBG2 protmoter sequence, or an HFE, GBB, or F8 gene sequence). Such complexes may be useful for increasing expression of fetal hemoglobin or correcting a poing mutation (e.g., C282Y) in HFE. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/460178 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124907 | TRACEWELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | Zymergen Inc. (Emeryville, California) |
| INVENTOR(S) | Cara Ann TRACEWELL (Walnut Creek, California); Alexander Glennon SHEARER (San Francisco, California); Michael Shareef SIDDIQUI (Oakland, California); Steven M. EDGAR (Albany, California); Nicolaus HERMAN (El Cerrito, California); Murtaza Shabbir HUSSAIN (Emeryville, California) |
| ABSTRACT | The present disclosure describes the engineering of microbial cells for fermentative production of histamine and provides novel engineered microbial cells and cultures, as well as related histamine production methods. |
| FILED | Monday, July 10, 2023 |
| APPL NO | 18/349895 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/18 (20130101) C12N 1/20 (20130101) C12N 9/0006 (20130101) C12N 9/88 (20130101) C12N 9/1077 (20130101) C12N 15/77 (20130101) C12N 15/81 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/10 (20130101) Original (OR) Class Enzymes C12Y 101/01023 (20130101) C12Y 101/01049 (20130101) C12Y 204/02017 (20130101) C12Y 206/01009 (20130101) C12Y 207/06001 (20130101) C12Y 301/03015 (20130101) C12Y 305/04019 (20130101) C12Y 306/01031 (20130101) C12Y 401/01022 (20130101) C12Y 402/01019 (20130101) C12Y 403/02 (20130101) C12Y 503/01016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124910 | Jewett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Joongoo Lee (Evanston, Illinois); Eric V. Anslyn (Austin, Texas); Jaime Coronado (Austin, Texas); Jongdoo Lim (Austin, Texas) |
| ABSTRACT | Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/264025 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124935 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Yong-Chen Lu (Little Rock, Arkansas); Peter Fitzgerald (Silver Spring, Maryland); Zhili Zheng (Gaithersburg, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed are methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences, or an antigen-binding portion thereof. Also disclosed are methods of automatically identifying the TCR alpha and beta chain V segment sequences and CDR3 sequences of a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Methods of preparing a population of cells that express paired TCR alpha and beta chain sequences, or an antigen-binding portion thereof, are also disclosed. Isolated pairs of TCR alpha and beta chain sequences and isolated populations of cells prepared by the methods are also disclosed. |
| FILED | Wednesday, December 27, 2023 |
| APPL NO | 18/397448 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/7051 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/1003 (20130101) C12N 15/1096 (20130101) C12N 2502/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) G16B 30/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124945 | Del Vecchio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Domitilla Del Vecchio (Cambridge, Massachusetts); Hsin-Ho Huang (Arlington, Massachusetts); Carlos Barajas (Cambridge, Massachusetts); Kalon J. Overholt (Somerville, Massachusetts); Simone Bruno (Cambridge, Massachusetts); Theodore W. Grunberg (Cambridge, Massachusetts) |
| ABSTRACT | A collecting system is provided that can include a probe configured to collect pathogens from a surrounding fluid, an elution chamber containing a liquid solvent and configured to receive the probe to elute the pathogens collected on the probe using the liquid solvent, and a heater configured to lyse the pathogens to release the genetic material of the pathogens into the liquid solvent. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/277268 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 7/52 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/70 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 15/1436 (20130101) G01N 2015/011 (20240101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125241 | Power |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bronwyn Power (New Haven, Connecticut) |
| ABSTRACT | An airfoil includes a high pressure surface and a low pressure surface that are connected at a leading edge and a trailing edge. The high pressure surface and the low pressure surface extend from a first end to a second end. A camber line extends between the leading edge and the trailing edge and a camber angle is defined as a plurality of camber-angle distributions that extend between the leading edge end and the trailing edge. The plurality of camber-angle distributions include a uniform portion that extends from the leading edge to a forced non-equilibrium boundary layer diffusion (FNBD) feature. The uniform portion includes a non-dimensionalized camber-angle unit that is constant the FNBD feature includes a rapidly increasing camber-angle that is 0.2 non-dimensional camber-angle units higher than the non-dimensionalized camber-angle of the uniform portion. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/960514 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/041 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125247 | Scheitlin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gordon G. Scheitlin (Liberty Township, Ohio) |
| ABSTRACT | Systems and methods are provided herein that are useful to determining probabilistic burst for a component. In particular, the systems and methods generate an overspeed distribution for the component, the overspeed distribution being indicative of a probability that various overspeed values will be obtained. The method involves receiving field analytics data indicative of time the component spends in at least one operating condition and receiving overspeed data indicative of overspeed values for the component as a function of the at least one operating condition. The method further includes generating an overspeed distribution for the component based on the field analytics data and the overspeed data. A probability of burst for the component may then be determined based on the overspeed distribution. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966499 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 21/003 (20130101) F01D 21/04 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/80 (20130101) F05D 2270/44 (20130101) F05D 2270/71 (20130101) F05D 2270/304 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125599 | SHKEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andrei M. SHKEL (Irvine, California); Mohammad H. ASADIAN ARDAKANI (Irvine, California); Yusheng WANG (Irvine, California) |
| ABSTRACT | A dual-shell architecture and methods of fabrication of fused quartz resonators is disclosed. The architecture may include two encapsulated and concentric cavities using plasma-activated wafer bonding followed by the high-temperature glassblowing. The dual-shell architecture can provide a protective shield as well as a “fixed-fixed” anchor for the sensing element of the resonators. Structures can be instrumented to operate as a resonator, a gyroscope, or other vibratory sensor and for precision operation in a harsh environment. Methods for fabricating a dual-shell resonator structure can include pre-etching cavities on a cap wafer, pre-etching cavities on a device wafer, bonding the device wafer to a substrate wafer to form a substrate pair and aligning and bonding the cap wafer to the substrate pair to form a wafer stack with aligned cavities including a cap cavity and a device cavity. The wafer stack may be glassblown to form a dual-shell structure. |
| FILED | Thursday, July 06, 2023 |
| APPL NO | 18/347875 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0051 (20130101) B81B 2203/0172 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00182 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/5719 (20130101) Original (OR) Class Impedance Networks, e.g Resonant Circuits; Resonators H03H 3/0072 (20130101) H03H 9/1057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125653 | Andarawis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emad Andarawis Andarawis (Ballston Lake, New York); Aaron Jay Knobloch (Niskayuna, New York) |
| ABSTRACT | Techniques for using a pyrometer to measure one or more operating characteristics of a target are provided. In one example aspect, a pyrometer is oriented relative to a target having target elements spaced from one another such that, as the target is rotated, the pyrometer alternately i) senses a target element for a period of time; and ii) then does not sense any of the target elements for a period of time as no appreciable signal is received. The pyrometer generates an output signal having alternating target pulse widths and null widths. The target and null widths have different amplitudes. The amplitude of the null signal provides an amplitude baseline for which the amplitudes of the target widths or signals may be compared to so that a temperature or other operating characteristic associated with the target can be determined. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 17/964127 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 21/003 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2270/804 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/14 (20130101) Original (OR) Class G01J 5/042 (20130101) G01J 5/0088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125922 | Raj et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raghu Raj (Washington, District of Columbia); Ronald Lipps (Washington, District of Columbia) |
| ABSTRACT | Systems and methods are provided for synchronizing a bistatic inverse synthetic aperture radar (ISAR) imaging radar system using only the signal that travels directly between the transmitter and receiver. In an embodiment, an extracted direct path signal is used as a matched filter reference function. In an embodiment, full pulse compression is used for a matched filter implementation. Embodiments of the present disclosure provide systems and methods for detecting and extracting the direct path signal and using this direct path signal to synchronize the received signal stream in a bistatic ISAR system. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/375981 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/9058 (20190501) G01S 13/9064 (20190501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240126108 | Finkel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Finkel (Baltimore, Maryland); Thomas Mion (Ellicott City, Maryland); Margo Staruch (Alexandria, Virginia); Jakub Kolacz (Alexandria, Virginia); Alex Moser (Fort Washington, Maryland) |
| ABSTRACT | The present invention provides an optical switch capable of functioning as an optical limiter, modulator, and dynamic attenuator utilizing a ferroelectric single crystal as the functional medium. The functionality is based upon a dynamic ferroelectric-to-ferroelectric phase transition occurring in the single crystal which can be perturbed through a hysteretic transition from an opaque to transparent state through the application of a compressive stress, an electric field, or both to the crystal. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/379934 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240126138 | Puckett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| INVENTOR(S) | Matthew W. Puckett (Phoenix, Arizona); Chad Hoyt (Plymouth, Minnesota); Karl Nelson (Plymouth, Minnesota); Jianfeng Wu (Phoenix, Arizona) |
| ABSTRACT | An optical frequency comb generation system includes an optical waveguide portion having a uniform width, a first chirped Bragg grating disposed at one end of the optical waveguide portion and a second chirped Bragg grating disposed at the other end of the optical waveguide portion. The first chirped Bragg grating includes at least a first periodic variation having a first refractive index and a second periodic variation having a second refractive index. The second chirped Bragg grating includes the at least first and second periodic variations. A first cavity associated with a first resonant frequency extends between the first periodic variation of the first chirped Bragg grating and the first periodic variation of the second chirped Bragg grating. A second cavity associated with a second resonant frequency extends between the second periodic variation of the first chirped Bragg grating and the second periodic variation of the second chirped Bragg grating. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 18/045936 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) Original (OR) Class G02F 1/3542 (20210101) G02F 2201/307 (20130101) G02F 2203/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240126680 | KEPPEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David KEPPEL (Mountain View, California); David OZOG (Ashland, Massachusetts); Lawrence STEWART (Wayland, Massachusetts); Sri Raj PAUL (Austin, Texas); Md RAHMAN (Bee Cave, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David KEPPEL (Mountain View, California); David OZOG (Ashland, Massachusetts); Lawrence STEWART (Wayland, Massachusetts); Sri Raj PAUL (Austin, Texas); Md RAHMAN (Bee Cave, Texas) |
| ABSTRACT | Various examples relate to apparatuses, devices, methods and computer programs for allocating memory. An apparatus comprises interface circuitry, machine-readable instructions, and processor circuitry to execute the machine-readable instructions to process instructions of a software application of a local processing element participating in a partitioned global address space, allocate, upon processing an instruction for allocating memory on a symmetric heap being used across a plurality of processing elements participating in the partitioned global address space, memory on the symmetric heap, wherein, if the instruction for allocating memory indicates that memory is to be allocated with a variable size, the memory allocated on the symmetric heap has a size that is specific for the local processing element. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/391714 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0223 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127032 | EVANUSA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MATTHEW S. EVANUSA (Hyattsville, Maryland) |
| ABSTRACT | A neural network apparatus includes a reservoir, which includes a recurrent neural network and receives at least one input temporal sequence. The recurrent neural network includes an initially unlearned input weight matrix and an initially unlearned recurrent weight matrix. The recurrent neural network includes a plurality of neurons. The input weight matrix projects the at least one input temporal sequence from a data space dimension into a dimensionally higher reservoir space dimension. The plurality of neurons receives the projected input temporal sequence and the random recurrent weight matrix and collectively outputs a plurality of reservoir state vectors, which is stacked to form a reservoir state matrix. The neural network apparatus also includes a readout including a one-dimensional, temporal convolutional neural network, which receives the reservoir state matrix from the reservoir. The one-dimensional, temporal convolutional network includes a stack of one-dimensional convolutional blocks, which convolves the reservoir state matrix over time. |
| FILED | Wednesday, October 18, 2023 |
| APPL NO | 18/381360 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/044 (20230101) Original (OR) Class G06N 3/0464 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127614 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Young L Kim (West Lafayette, Indiana); Jung Woo Leem (West Lafayette, Indiana) |
| ABSTRACT | A method of authenticating an item is disclosed which includes applying light to an item, wherein the item includes a random distribution of fluorescent particles disposed thereon, capturing one or more images from the item, generating a cryptographic pattern from the one or more captured images by a host processing system, communicating the cryptographic pattern to a remote processing system having a plurality of cryptographic keys in a database each uniquely associated with a corresponding item, comparing the cryptographic pattern with the plurality of cryptographic keys in the database, and communicating a positive evaluation for authentication to the host processing system if a match is found between one of the plurality of cryptographic keys and the communicated cryptographic pattern. |
| FILED | Saturday, August 15, 2020 |
| APPL NO | 17/768293 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/70 (20240101) G06T 2207/10064 (20130101) Image or Video Recognition or Understanding G06V 20/95 (20220101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127693 | Yucelen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tancel Yucelen (Tampa, Florida); Stefan Ristevski (Tampa, Florida); Jonathan Muse (Beavercreek, Ohio) |
| ABSTRACT | Methods and systems for information exchange of a vehicle in a networked multiagent system are disclosed. The methods and systems include: receiving a last neighbor dataset broadcasted by a neighbor vehicle; determining a current dataset based on the last neighbor dataset and a last vehicle dataset of the first vehicle; identifying a violation of an event-triggering condition by comparing a difference between the last vehicle dataset and the current dataset with a dynamic threshold; determining a transmission dataset being associated with the current dataset; and in response to the violation, broadcasting the transmission dataset to the neighbor vehicle. The dynamic threshold is defined by an exponentially decaying term and an error between a vehicle state of the first vehicle and a reference state. Other aspects, embodiments, and features are also claimed and described. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/344673 |
| CURRENT CPC | Traffic Control Systems G08G 1/0112 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127954 | Gilchrist et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Triangle Institute (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristin Hedgepath Gilchrist (Rockville, Maryland); Meghan Sarah Hegarty-Craver (Durham, North Carolina); Dorota Temple (Cary, North Carolina); Robert Furberg (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed herein are systems, methods, and devices of detecting illness in presymptomatic and asymptomatic infected persons using wearable sensor technology. In a first embodiment, a method is implemented on a computing device, the method includes receiving first sensor data associated with the person over a first period of time and applying the first sensor data to a multi-variate detection model. The method further includes receiving second sensor data associated with the person over a second period of time and applying the second sensor data to the multi-variate detection model. Further the method includes determining a probability value of the illness in the person using the multi-variate detection model and transmitting the probability value to a user interface (UI). |
| FILED | Thursday, December 28, 2023 |
| APPL NO | 18/398623 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/0022 (20130101) A61B 5/0024 (20130101) A61B 5/28 (20210101) A61B 5/352 (20210101) A61B 5/681 (20130101) A61B 5/742 (20130101) A61B 5/1102 (20130101) A61B 5/1118 (20130101) A61B 5/1455 (20130101) A61B 5/02405 (20130101) A61B 5/4266 (20130101) A61B 5/6823 (20130101) A61B 2505/07 (20130101) A61B 2560/045 (20130101) A61B 2560/0462 (20130101) A61B 2562/0219 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240122516 | Tian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Limei Tian (College Station, Texas); Myeong Namkoong (College Station, Texas) |
| ABSTRACT | In an embodiment, the present disclosure pertains to an electrode having a first layer and a second layer. In some embodiments, the first layer includes a conductive polymer. In some embodiments, the second layer is positioned above the first layer. In some embodiments, the second layer includes an inorganic material that forms a conductive network on the first layer. In an additional embodiment, the present disclosure pertains to a method of making an electrode. In general, the method providing a mold with a desired indented pattern, pouring a solution including a conductive polymer into the indented pattern to form a first layer, and pouring a solution including an inorganic material onto the first layer to form a second layer. In some embodiments, the inorganic material forms a conductive network on the first layer. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 18/278763 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/257 (20210101) A61B 5/268 (20210101) Original (OR) Class A61B 2562/125 (20130101) A61B 2562/0215 (20170801) A61B 2562/0285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122808 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (GAINESVILLE, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Huang (Gainesville, Florida); Yifei Jin (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for coaxial nozzles, capsule fabrication systems comprising coaxial nozzles, and methods of capsule fabrication using capsule fabrication systems. In certain embodiments, coaxial nozzle configurations, capsule fabrication systems, and methods as described herein can be used for multi-layered capsule fabrication. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/380982 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 3/07 (20130101) A61J 3/074 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 9/4808 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/3086 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 81/3216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240122876 | Tochtrop et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Tochtrop (Cleveland, Ohio); Philip Kiser (Cleveland, Ohio); Jianye Zhang (Cleveland, Ohio); Krzysztof Palczewski (Oakland, California) |
| ABSTRACT | A method of treating an ocular disorder in a subject in need thereof includes administering to the subject a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, tautomer, or solvate thereof. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 18/263758 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123075 | JIANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Shaoyi JIANG (Redmond, Washington); Priyesh JAIN (Seattle, Washington); Jinrong MA (Seattle, Washington); Bowen Li (Seattle, Washington) |
| ABSTRACT | N-oxide and monomers, N-oxide polymers and copolymers, methods for making the N-oxide monomers, polymers, and copolymers, compositions and materials that include N-oxide polymers and copolymers, and methods for using the N-oxide monomers, N-oxide polymers, and N-oxide copolymers. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/356932 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5138 (20130101) A61K 47/58 (20170801) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/34 (20130101) A61L 29/085 (20130101) A61L 31/10 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/60 (20130101) C08F 220/603 (20200201) C08F 222/225 (20200201) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 2300/206 (20130101) C08J 2333/26 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123428 | HERMANS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ive HERMANS (Middleton, Wisconsin); Lesli MARK (Madison, Wisconsin); William MCDERMOTT (Madison, Wisconsin); Theodore AGBI (Madison, Wisconsin) |
| ABSTRACT | Improved catalytic materials for and methods of oxidative dehydrogenation (ODH) of short chain alkanes or ethylbenzene to the corresponding olefins are disclosed. The disclosed methods use catalysts made by impregnating boron onto the surface of oxidized amorphous carbon, and result in higher selectivity and a lower induction period than methods using conventional ODH catalysts. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/263966 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 6/001 (20130101) B01J 21/02 (20130101) B01J 21/18 (20130101) Original (OR) Class B01J 37/08 (20130101) B01J 37/14 (20130101) B01J 37/0201 (20130101) Acyclic or Carbocyclic Compounds C07C 5/333 (20130101) C07C 2521/02 (20130101) C07C 2521/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123616 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Aaron Johnson (Pittsburgh, Pennsylvania); Sarah Bergbreiter (Pittsburgh, Pennsylvania); Kamal Carter (Pittsburgh, Pennsylvania); Sharfin Islam (Pittsburgh, Pennsylvania); Justin Yim (PIttsburgh, Pennsylvania); James Kyle (Pittsburgh, Pennsylvania) |
| ABSTRACT | A bipedal walking robot uses a quasi-passive control scheme and a simplified mechanical design. The walking robot has a pair of legs connected to a body through a passive hip joint, which is offset from a center of gravity of the walking robot. A nonconcentric, curved foot is attached at to each leg by a prismatic joint. Extension and retraction of the prismatic joint initiates the walking sequence of the robot, with each foot retracted during the swing phase and extended during the stance phase. Directional changes are controlled by changing a phase offset in the actuation of each foot. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/379614 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1664 (20130101) Original (OR) Class Motor Vehicles; Trailers B62D 57/032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124313 | Nandwana et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vikas Nandwana (Evanston, Illinois); Vinayak P. Dravid (Glenview, Illinois) |
| ABSTRACT | Methods for making nanocomposites are provided. In an embodiment, such a method comprises combining a first type of nanostructure with a bulk material in water or an aqueous solution, the first type of nanostructure functionalized with a functional group capable of undergoing van der Waals interactions with the bulk material, whereby the first type of nanostructure induces exfoliation of the bulk material to provide a second, different type of nanostructure while inducing association between the first and second types of nanostructures to form the nanocomposite. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/157947 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) C01B 32/19 (20170801) Original (OR) Class Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/06 (20130101) C01G 49/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/77 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124315 | BARSOUM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michel W. BARSOUM (Moorestown, New Jersey); Varun R. NATU (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are methods for etching MAX-phase materials to produce MXenes, the etching being accomplished by a salt, one or both of a polar and a non-polar solvent, and optionally a crown ether, the etching also being optionally performed in a water-free or essentially water-free manner. Also provided are related systems and methods. |
| FILED | Wednesday, October 14, 2020 |
| APPL NO | 17/768245 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 4/001 (20130101) B01J 8/0278 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/921 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/74 (20130101) C01P 2002/85 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2004/24 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124379 | Subramaniam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bala Subramaniam (Lawrence, Kansas); Hongda Zhu (Lawrence, Kansas); Timothy A. Jackson (Lawrence, Kansas) |
| ABSTRACT | Processes for oxidizing alkanes are provided. In embodiments, such a process comprises combining an alkane, e.g., isobutane, and ozone in a liquid phase medium comprising a protic additive, e.g., water, under conditions sufficient to oxidize the alkane to products comprising a hydroxylate. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 18/278329 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 29/48 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124476 | Isaacs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lyle David Isaacs (Silver Spring, Maryland); Volker Briken (Laurel, Maryland); Gaya Hettiarachchi (Arlington, Virginia); Da Ma (Carrboro, North Carolina); Duc M. Nguyen (Miami, Florida) |
| ABSTRACT | Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable. |
| FILED | Tuesday, December 26, 2023 |
| APPL NO | 18/396432 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) A61K 31/787 (20130101) A61K 47/22 (20130101) Heterocyclic Compounds C07D 487/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124645 | Bowman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Delaware, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher N. Bowman (Boulder, Colorado); Brady T. Worrell (Englewood, Colorado); Juan J. Hernandez (Longmont, Colorado); Matthew K. McBride (Boulder, Colorado); Sijia Huang (Dublin, California); Maciej Podgorski (Boulder, Colorado) |
| ABSTRACT | Described herein is a composition for producing a thiol-ene covalent adaptable network (CAN) polymer. The composition includes a first monomer including at least one thiol group; and a second monomer including at least one anhydride functional group and at least one alkene functional group. Also described herein are a polymer produced from the composition, a method of producing the polymer using the composition, a method of fabricating a polymer article using the composition, as well as a method of degrading the polymer. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 18/267348 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/78 (20130101) C08G 63/688 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124667 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Guang-lin Zhao (Baton Rouge, Louisiana); Rong Zhao (Huaibel in Anhui province, China PRC) |
| ASSIGNEE(S) | Southern University and A and M College (, None) |
| INVENTOR(S) | Guang-lin Zhao (Baton Rouge, Louisiana); Rong Zhao (Huaibel in Anhui province, China PRC) |
| ABSTRACT | A process for forming multifunctional carbon nanotubes-glass fiber-epoxy composites with high density interfaces for microwave absorption and structural materials application useful as a multifunctional microwave absorption and low-weight structural material without a need of additional coating. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 17/965722 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 7/22 (20130101) B29B 7/88 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/003 (20210501) B29C 70/22 (20130101) B29C 70/30 (20130101) B29C 70/081 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/244 (20210501) C08J 5/249 (20210501) Original (OR) Class C08J 2363/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) C08K 2201/003 (20130101) C08K 2201/004 (20130101) C08K 2201/011 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 9/009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124714 | Rathnamalala et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Chathuranga S.L. Rathnamalala (Starkville, Mississippi); Colleen N. Scott (Starkville, Mississippi) |
| ASSIGNEE(S) | Mississippi State University (Starkville, Mississippi) |
| INVENTOR(S) | Chathuranga S.L. Rathnamalala (Starkville, Mississippi); Colleen N. Scott (Starkville, Mississippi) |
| ABSTRACT | A near infrared dye comprising a counterion and a structure of Formula I wherein the at least one of R1 and R2are 1-(thiophen-2-yl)piperidine, 1-(thieno[3,2-b]thiophen-2-yl)piperidine or 1-([2,2′-bithiophen]-5-yl)piperidine, and X, R, R3-R4, R19, R20 and R22-R29 are disclosed herein. Materials and compositions comprising the NIR dye can absorb light in the NIR I & II regions and then the energy can be released in the form of light (fluorescence) or heat (non-radiative). The dyes can also convert the absorbed light to heat and ultrasound waves via the photoacoustic effect. The photoacoustic effect can be used in photoacoustic tomography to image biological materials or processes. Methods for synthesizing the NIR dyes and materials comprising the same are also disclosed. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/470005 |
| CURRENT CPC | Heterocyclic Compounds C07D 409/14 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 11/28 (20130101) Original (OR) Class C09B 67/0063 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/02 (20130101) C09K 11/06 (20130101) C09K 2211/1007 (20130101) C09K 2211/1018 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 2001/302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124726 | Mallavarapu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Akhila Mallavarapu (Philadelphia, Pennsylvania); Chavez FK Lawrence (Philadelphia, Pennsylvania); Cherie R. Kagan (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | Provided are nanostructure imprinting processes that utilize dispersions of nanoparticles in aqueous solvents. Also provided are nanostructure imprinting processes that utilize temperature-sensitive solvents that can be thinned via application of temperature. Such solvents allow for formation of nanostructures of particular height. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/483862 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/037 (20130101) Original (OR) Class Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124861 | Sonnenburg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Novome Biotechnologies, Inc. (Daly City, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin L. Sonnenburg (Redwood City, California); Weston R. Whitaker (Daly City, California); Elizabeth Stanley (Portola Valley, California); William C. DeLoache (Oakland, California) |
| ABSTRACT | Compositions and methods are provided for modulating growth of a genetically modified bacterial cell present in a human organ, for modulating growth of a genetically modified bacterial cell in an organ (e.g., gut), for displacing at least a portion of a population of bacterial cells in an organ, and for facilitating gut colonization by a genetically modified bacterial cell. Also provided are genetically modified bacterial cells, e.g., cells that include a heterologous carbohydrate-utilization gene or gene set that provides for the ability to utilize as a carbon source a rare carbohydrate of interest that is utilized as a carbon source by less than 50% of bacterial cells present in a human microbiome. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/391513 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/2402 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/74 (20130101) Enzymes C12Y 302/01178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124899 | Hamberger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Björn Hamberger (Okemos, Michigan); Sean Johnson (Bedford, Massachusetts); Wajid Waheed Bhat (Haslett, Michigan) |
| ABSTRACT | Enzymes and methods are described herein for manufacturing terpenes, including terpenes. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458762 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1022 (20130101) C12N 9/1085 (20130101) C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/002 (20130101) Original (OR) Class C12P 17/02 (20130101) C12P 17/06 (20130101) Enzymes C12Y 202/01007 (20130101) C12Y 205/01029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124932 | Daugharthy et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan R. Daugharthy (Cambridge, Massachusetts); George M. Church (Brookline, Massachusetts) |
| ABSTRACT | The disclosure provides a method for detecting a target analyte in a biological sample including contacting the sample with one or more probe sets each comprising a primary probe and a linker, contacting the sample with an initiator sequence, contacting the sample with a plurality of fluorescent DNA hairpins, wherein the probe binds the target molecule, the linker connects the probe to the initiator sequence, and wherein the initiator sequence nucleates with the cognate hairpin and triggers self-assembly of tethered fluorescent amplification polymers, and detecting the target molecule by measuring fluorescent signal of the sample. |
| FILED | Monday, June 12, 2023 |
| APPL NO | 18/332933 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 2310/16 (20130101) C12N 2320/10 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6806 (20130101) C12Q 1/6816 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125047 | McGuinness et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily K. McGuinness (Atlanta, Georgia); Mark D. Losego (Atlanta, Georgia); Haley V. Manno (Atlanta, Georgia); Nicole R. McClelland (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a method of affixing molecules to a polymer material, comprising: placing the polymer material in a reactor; removing at least a portion of sorbed water present in the polymer material; exposing the polymer material to a metal precursor to produce an inorganic-organic polymer hybrid material; and soaking the polymer hybrid material in a solution comprising the molecules. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/378223 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 7/12 (20130101) C08J 7/065 (20130101) C08J 2333/20 (20130101) C08J 2367/02 (20130101) C08J 2377/06 (20130101) Dyeing or Printing Textiles; Dyeing Leather, Furs or Solid Macromolecular Substances in Any Form D06P 1/34 (20130101) D06P 1/67341 (20130101) D06P 3/52 (20130101) D06P 5/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240126008 | Westerhoff et al. |
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| FUNDED BY |
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| APPLICANT(S) | Paul K. Westerhoff (Scottsdale, Arizona); Hojung Rho (Seoul, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul K. Westerhoff (Scottsdale, Arizona); Hojung Rho (Seoul, South Korea) |
| ABSTRACT | A composite material includes one or more side-emitting optical fibers arranged in a pattern defining openings bounded at least in part by the one or more side-emitting optical fibers. The one or more side-emitting optical fibers have a UV-C transparent coating, and at least one of the one or more side-emitting optical fibers is configured to be coupled to a light-emitting diode. A reverse osmosis filter includes a reverse osmosis membrane and the composite material coupled to the reverse osmosis membrane. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482265 |
| CURRENT CPC | Separation B01D 61/08 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/104 (20130101) Optical Elements, Systems, or Apparatus G02B 6/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240126258 | Chowdhary et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Girish Chowdhary (Champaign, Illinois); Chinmay P. Soman (Urbana, Illinois); Beau David Barber (Ogden, Illinois) |
| ABSTRACT | The present disclosure provides a system for monitoring unstructured environments. A predetermined path can be determined according to an assignment of geolocations to one or more agronomically anomalous target areas, where the one or more agronomically anomalous target areas are determined according to an analysis of a plurality of first images that automatically identifies a target area that deviates from a determination of an average of the plurality of first images that represents an anomalous place within a predetermined area, where the plurality of first images of the predetermined area are captured by a camera during a flight over the predetermined area. A camera of an unmanned vehicle can capture at least one second image of the one or more agronomically anomalous target areas as the unmanned vehicle travels along the predetermined path. |
| FILED | Tuesday, June 27, 2023 |
| APPL NO | 18/342270 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0038 (20130101) Original (OR) Class Electric Digital Data Processing G06F 16/29 (20190101) G06F 18/2178 (20230101) Image or Video Recognition or Understanding G06V 10/22 (20220101) G06V 10/763 (20220101) G06V 10/7784 (20220101) G06V 20/17 (20220101) G06V 20/188 (20220101) Traffic Control Systems G08G 5/0039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240126947 | Tamijani et al. et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ali Tamijani et al. (Ormond Beach, Florida); Zhichao Wang (Port Orange, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali Tamijani et al. (Ormond Beach, Florida); Zhichao Wang (Port Orange, Florida) |
| ABSTRACT | A machine-implemented method for establishing optimized parameters defining a model of a coated structure with a lattice infill can include receiving constraints for the model of the coated structure. The machine-implemented method can also include initializing a lattice infill defined by respective lattice cells according to the constraints for the model of the coated structure. The machine-implemented method can also include optimizing the lattice infill and a shape of the coated structure by iteratively modifying the lattice infill and the shape of the coated structure and evaluating a strength-based criterion. The machine-implemented method can also include generating, using the optimized lattice infill and the optimized shape of the coated structure with the lattice infill, a representation of the model of the coated structure with the lattice infill conforming to the constraints for the model of the coated structure. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/480746 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/02 (20141201) Electric Digital Data Processing G06F 30/17 (20200101) G06F 30/20 (20200101) Original (OR) Class G06F 2111/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240126972 | NADERI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yousof NADERI (Brookline, Massachusetts); Kaushik CHOWDHURY (Needham, Massachusetts) |
| ABSTRACT | Programmatic development of a software-defined wireless charging apparatus capable of charging multiple and different devices simultaneously is presented. Developer software is used to input specifications for the charging apparatus and generate configuration files that are used to configure operating software for the charging apparatus. The developer software can also design configurable hardware for fabrication of the charging apparatus, and can provide diagnostic data for use in optimizing the charging apparatus design. Wireless charging systems having novel capabilities are also provided. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 18/277402 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/12 (20200101) G06F 30/392 (20200101) Original (OR) Class G06F 2115/12 (20200101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0013 (20130101) H02J 7/00034 (20200101) H02J 7/00047 (20200101) H02J 50/005 (20200101) H02J 50/10 (20160201) H02J 50/80 (20160201) H02J 50/90 (20160201) H02J 50/402 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240126989 | HERR et al. |
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| FUNDED BY |
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| APPLICANT(S) | BLACKBOILER, INC. (Arlington, Virginia) |
| ASSIGNEE(S) | BLACKBOILER, INC. (Arlington, Virginia) |
| INVENTOR(S) | Jonathan HERR (Washington, District of Columbia); Daniel Edward SIMONSON (Syracuse, New York); Daniel P. BRODERICK (Ashburn, Virginia) |
| ABSTRACT | A method for suggesting revisions to a document-under-analysis from a seed database, the seed database including a plurality of original texts each respectively associated with one of a plurality of final texts, the method for suggesting revisions including selecting a statement-under-analysis (“SUA”), selecting a first original text of the plurality of original texts, determining a first edit-type classification of the first original text with respect to its associated final text, generating a first similarity score for the first original text based on the first edit-type classification, the first similarity score representing a degree of similarity between the SUA and the first original text, selecting a second original text of the plurality of original texts, determining a second edit-type classification of the second original text with respect to its associated final text, generating a second similarity score for the second original text based on the second edit-type classification, the second similarity score representing a degree of similarity between the SUA and the second original text, selecting a candidate original text from one of the first original text and the second original text, and creating an edited SUA (“ESUA”) by modifying a copy of the first SUA consistent with a first candidate final text associated with the first candidate original text. |
| FILED | Wednesday, June 07, 2023 |
| APPL NO | 18/330484 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/35 (20190101) G06F 16/36 (20190101) G06F 16/383 (20190101) G06F 40/45 (20200101) G06F 40/131 (20200101) G06F 40/137 (20200101) G06F 40/166 (20200101) G06F 40/169 (20200101) G06F 40/194 (20200101) G06F 40/253 (20200101) Original (OR) Class G06F 40/268 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127040 | Shiflett et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio University (Athens, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Shiflett (Chillicothe, Ohio); Avinash Karanth (Canal Winchester, Ohio) |
| ABSTRACT | Devices and methods for performing computations for neural networks. A photonic locally-connected unit for a neural network accelerator includes a plurality of optical modulators, a positive accumulation waveguide, a negative accumulation waveguide, a plurality of optical adders, and first and second photodetectors. Each optical modulator receives a respective input optical signal and a respective electrical signal. Each optical signal is indicative of a value of input element, and each electrical signal is indicative of the value of a weight. Each optical modulator modulates the received input optical signal with the received electrical signal to generate a weighted optical signal. Each optical adder selectively couples one of the respective weighted optical signals into one of the positive or negative accumulation waveguides based on whether the respective weight is positive or negative. The first and second photodetectors generate an output current based on optical signals received from the accumulation waveguides. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/263173 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0464 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127069 | NAJAF et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF LOUISIANA LAFAYETTE (Lafayette, Louisiana) |
| ASSIGNEE(S) | UNIVERSITY OF LOUISIANA LAFAYETTE (Lafayette, Louisiana) |
| INVENTOR(S) | Mohammadhassan NAJAF (Lafayette, Louisiana); Reza HOJABR (Vancouver, Canada); Kamyar GIVAKI (Tehran, Iran); Kossar POURAHMADI (Baltimore, Maryland); Parsa NOORALINEJAD (Baltimore, Maryland); Ahmad KHONSARI (Tehran, Iran); Dara RAHMATI (Tehran, Iran) |
| ABSTRACT | An accelerator for training deep neural networks is provided. The accelerator includes a baseline architecture having an input buffer, a weight buffer, an output buffer, a buffer controller, and a two-dimensional array of processing elements. The array of processing elements is used in both convolutional and fully connected layers. The convolutional layer includes multiple filters. The output of each said filter in said convolutional layers is achieved by a weighted summation. In a preferred embodiment, each convolutional and fully connected layer is equipped with input/output buffers that fetch/store the input/output data. In a particularly preferred embodiment, each processing element can access the weight buffer that holds the weight vector. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/961396 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) G06N 3/084 (20130101) Original (OR) Class G06N 3/0464 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127092 | KING et al. |
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| FUNDED BY |
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| APPLICANT(S) | Atom Computing Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan KING (Oakland, California); Benjamin BLOOM (Berkeley, California); Brian LESTER (Berkeley, California) |
| ABSTRACT | The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation. |
| FILED | Wednesday, September 20, 2023 |
| APPL NO | 18/470604 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/33 (20130101) Optical Computing Devices; G06E 3/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127363 | Chiaradonna et al. |
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| FUNDED BY |
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| APPLICANT(S) | Stefano Chiaradonna (Tempe, Arizona); Petar Jevtic (Chandler, Arizona); Nicolas Lanchier (Gilbert, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Stefano Chiaradonna (Tempe, Arizona); Petar Jevtic (Chandler, Arizona); Nicolas Lanchier (Gilbert, Arizona) |
| ABSTRACT | A computing system includes a processor having access to data associated with a plurality of devices of a network. The processor is configured to leverage the data to execute a loss model that estimates cyber risk loss distribution of the network associated with healthcare environment and infrastructure using bond percolation on a mixed random graphs approach. |
| FILED | Monday, April 10, 2023 |
| APPL NO | 18/132918 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 40/12 (20131203) Original (OR) Class G06Q 50/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240127691 | GUERIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelleher GUERIN (Baltimore, Maryland); Gregory HAGER (Baltimore, Maryland) |
| ABSTRACT | Provided is a method, device, and computer-readable medium for controlling a robot graphic user interface (“RGUI”) on a mobile device. The method can include determining a distance, a position, or both of the mobile device with respect to a first robot; and causing, by a processor, a first RGUI to be displayed on a display of the mobile device based on the determining. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507870 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/409 (20130101) G05B 2219/39384 (20130101) G05B 2219/40382 (20130101) Transmission Systems for Measured Values, Control or Similar Signals G08C 17/02 (20130101) Original (OR) Class G08C 2201/20 (20130101) G08C 2201/30 (20130101) G08C 2201/70 (20130101) G08C 2201/91 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240128505 | LAVALLO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California); UCHICAGO ARGONNE, LLC (CHICAGO, Illinois) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California); UCHICAGO ARGONNE, LLC (CHICAGO, Illinois) |
| INVENTOR(S) | Vincent LAVALLO (Riverside, California); Anton TOMICH (Riverside, California); Christopher S. JOHNSON (Argonne, Illinois); Lei CHENG (Naperville, Illinois); Eungje LEE (Lemont, Illinois); Jehee PARK (Woodridge, Illinois); Jihyeon GIM (Naperville, Illinois); Ethan Phillip KAMPHAUS (Chicago, Illinois) |
| ABSTRACT | An anode in an electrochemical cell includes an anode active material comprising sodium and a solid electrolyte interphase (SEI) layer disposed on the anode active material. The SEI layer includes reduction products of an electrolyte solvent and is free of degradation products derived from dissolved anions of an electrolyte salt. The electrolyte solvent and the electrolyte salt are present in an electrolyte of the electrochemical cell. The SEI layer does not include a fluorine content greater than 5 wt. %. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488971 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/044 (20130101) H01M 4/381 (20130101) H01M 10/26 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240128514 | Shao-Horn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Yang Shao-Horn (Newton, Massachusetts); Ju LI (Weston, Massachusetts); Jeremiah Johnson (Boston, Massachusetts); Wenxu Zhang (Belmont, Massachusetts); Mingjun Huang (Everett, Massachusetts); Weijiang XUE (Chestnut Hill, Massachusetts); Yanhao Dong (Hefei, China PRC) |
| ABSTRACT | An electrochemical device includes a transition metal oxide cathode, such as LiNi0.8Co0.1Mn0.1O2, and an electrolyte. The electrolyte includes N, N-dimethyltrifluoromethane-sulfonamide (DMTMSA) and lithium bis(fluorosulfonyl)imide (LiFSI). The DMTMSA and LiFSI may be either the primary component of the electrolyte or an additive in the electrolyte. The electrochemical device may also include a graphite anode or a lithium metal anode. With a lithium metal anode, the electrochemical device has an initial specific capacity of at least 231 mAh g−1. Over at least 100 cycles (upper cut-off voltage of 4.7±0.05 V vs. Li/Li+), the electrochemical device maintains an average specific capacity of at least 88% of the initial specific capacity and an average Coulombic efficiency of at least about 99.65%. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/547123 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/052 (20130101) H01M 10/446 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240128741 | Mehraeen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shahab Mehraeen (Baton Rouge, Louisiana); Sudipta Sen (Baton Rouge, Louisiana) |
| ABSTRACT | An embodiment of a DC circuit breaker system includes a first mechanical switch, a first parallel capacitor connecting a first terminal and a second terminal of the first mechanical switch, a second mechanical switch in series with the first mechanical switch, a second parallel capacitor connecting a first terminal and a second terminal of the second mechanical switch, a first diode connecting the first terminal and the second terminal; and a second diode connecting the first terminal and the second terminal. According to the present disclosure, the first mechanical switch initiates a separation of contacts in response to a fault current; the second mechanical switch initiates a separation of contacts in response to the fault current; and opening of the first and second mechanical switches and turning off of the first and second diodes reverse a direction of a current flow and clear a current fault. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482609 |
| CURRENT CPC | Emergency Protective Circuit Arrangements H02H 7/268 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240123113 | Mentzer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven James Mentzer (Boston, Massachusetts) |
| ABSTRACT | The present disclosure describes bioadhesive polymer composition comprising: a first film comprising a polymer comprising: i) high-methoxyl pectin (HMP) and ii) an initial water content ranging from about 37% to about 43% (w/w); and a second film comprising a polymer comprising: i) HMP and ii) an initial water content ranging from about 9% to about 13% (w/w), wherein the first and second films are adhered to each other. Methods of preparing the bioadhesive polymer compositions and methods of sealing an ocular injury in an eye of a subject are also described. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 18/276540 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/08 (20130101) Original (OR) Class A61L 24/0015 (20130101) A61L 24/0042 (20130101) A61L 2430/16 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 105/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123398 | HAMDAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PLUG POWER INC. (Latham, New York) |
| ASSIGNEE(S) | PLUG POWER INC. (Latham, New York) |
| INVENTOR(S) | Monjid HAMDAN (Worcester, Massachusetts); Cortney MITTELSTEADT (Wayland, Massachusetts); Matthew WEAVER (Cambridge, Massachusetts); Robert STONE (Danvers, Massachusetts) |
| ABSTRACT | Method and system for electrochemically compressing hydrogen. In one embodiment, the system includes a membrane electrode assembly (MEA) that includes a polymer electrolyte membrane (PEM), an anode, and a cathode. First and second gas diffusion media are positioned adjacent the cathode and anode, respectively. A humidifying membrane is positioned next to the second gas diffusion medium on a side opposite the anode. A water supply is connected to the humidifying membrane, and a hydrogen gas supply is connected to the second gas diffusion medium. A hydrogen gas collector including a back pressure regulator is connected to the first gas diffusion medium. Separators, positioned on opposite sides of the MEA, are connected to a power source. In use, hydrogen is electrochemically pumped across the MEA and collected in the hydrogen gas collector. The PEM is kept properly humidified by the humidifying membrane, which releases water into the second gas diffusion medium. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392311 |
| CURRENT CPC | Separation B01D 53/326 (20130101) Original (OR) Class Non-metallic Elements; Compounds Thereof; C01B 3/02 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 9/00 (20130101) C25B 9/19 (20210101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/248 (20130101) H01M 8/0273 (20130101) H01M 8/1004 (20130101) H01M 8/1044 (20130101) H01M 8/04149 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123428 | HERMANS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ive HERMANS (Middleton, Wisconsin); Lesli MARK (Madison, Wisconsin); William MCDERMOTT (Madison, Wisconsin); Theodore AGBI (Madison, Wisconsin) |
| ABSTRACT | Improved catalytic materials for and methods of oxidative dehydrogenation (ODH) of short chain alkanes or ethylbenzene to the corresponding olefins are disclosed. The disclosed methods use catalysts made by impregnating boron onto the surface of oxidized amorphous carbon, and result in higher selectivity and a lower induction period than methods using conventional ODH catalysts. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/263966 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 6/001 (20130101) B01J 21/02 (20130101) B01J 21/18 (20130101) Original (OR) Class B01J 37/08 (20130101) B01J 37/14 (20130101) B01J 37/0201 (20130101) Acyclic or Carbocyclic Compounds C07C 5/333 (20130101) C07C 2521/02 (20130101) C07C 2521/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123679 | Pino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruben A. Pino (Kansas City, Missouri); Ryan J. Eickbush (Kansas City, Missouri) |
| ABSTRACT | A nozzle holder assembly for a three-dimensional printer comprises a mount, a printer nozzle, and a locking mechanism. The mount is operable to be secured to the three-dimensional printer. The printer nozzle shaft is movably coupled to the mount along a predetermined length. The locking mechanism is configured to fix the printer nozzle shaft relative to the mount at any position along the predetermined length. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537264 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/25 (20170801) B29C 64/209 (20170801) Original (OR) Class B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240123990 | Follen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth M. Follen (Greenwood, Indiana); Rohinish Gupta (Columbus, Indiana); Jonathan A. Dickson (Columbus, Indiana) |
| ABSTRACT | A vehicle system, apparatus, and/or method is provided. The vehicle system includes a powertrain including a prime mover and a transmission, and an electronic control system in operative communication with the powertrain including an adaptive cruise control (ACC) controller. The electronic control system is configured to determine a speed profile for a vehicle-in-front of the vehicle system while operating the vehicle system along a route. In response to the speed profile for the vehicle-in-front, the electronic control system is further configured to modify one or more output parameters of the powertrain to control one or more of a vehicle speed, a vehicle acceleration, and a vehicle deceleration of the vehicle system to inhibit control of the one or more output parameters by the ACC controller. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 18/047320 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/17 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124381 | BECKHAM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Wisconsin Alumni Research Foundation (Madison, Wisconsin); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregg Tyler BECKHAM (Golden, Colorado); Shannon Scot STAHL (Madison, Wisconsin); Jack TWILTON (Hayward, California); Yuriy ROMÁN (Cambridge, Massachusetts); Caroline Bradshaw HOYT-ANDERSON (Jacksonville, Florida); Zhiming SU (Madison, Wisconsin) |
| ABSTRACT | Described herein are systems and methods for the generation of bio-based plasticizers from lignin from 4-hydroxybenzoic acid (H), vanillic acid (G) and syringic acid (S) obtained via oxidative depolymerization of lignin substrates. Chemical and electrochemical methods are described for catalytic reductive coupling of sulfonate derivatives of H, G and S to generate all possible homo- and cross-coupling products. Advantageously, the provided systems and methods allow for the generation of renewable plasticizers that exhibit performance advantages relative to established petroleum-based phthalate ester plasticizers. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485388 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/44 (20130101) B01J 23/892 (20130101) Acyclic or Carbocyclic Compounds C07C 67/00 (20130101) Original (OR) Class C07C 303/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124670 | BERTINO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Massimo BERTINO (Glen Allen, Virginia); Tristan MOON (Richmond, Virginia); Dustin CLIFFORD (Richmond, Virginia); Jonathan KO (West Bethesda, Maryland); Gordon WALLER (Washington, District of Columbia) |
| ABSTRACT | An open cell foam, and particularly aerogels or other foams, having an inorganic, hydraded phase change material (PCM) embedded within pores or cells or a network within the foam have fire retardant, fire resistant and thermal insulating properties. These composite materials are preferably monolithic in character, and are mechanically robust allowing for example the attachment of nails or screws. With the PCM distributed throughout the open cell foam, the composite material has a wide array of applications including providing thermal, fire resistant, and fire retardant uses in battery containers, in automotives and other vehicles, etc. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/376564 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/0009 (20130101) Original (OR) Class C08J 9/224 (20130101) C08J 9/286 (20130101) C08J 2201/0502 (20130101) C08J 2205/05 (20130101) C08J 2205/026 (20130101) C08J 2207/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/14 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 59/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124676 | Korey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matt Korey (Oak Ridge, Tennessee); Halil Tekinalp (Oak Ridge, Tennessee); Soydan Ozcan (Oak Ridge, Tennessee); Peter Wang (Oak Ridge, Tennessee); Amber Hubbard (Oak Ridge, Tennessee); David Nuttall (Oak Ridge, Tennessee); Mitchell Rencheck (Oak Ridge, Tennessee) |
| ABSTRACT | A improved method of additive manufacturing of a recycled granulate is provided. The method comprises providing a starting article. A shredder shreds the starting article to give a shredded product. A granulator shreds the shredded product to give a recycled granulate. The recycled granulate is fed into an additive manufacturing machine. The additive manufacturing machine prints a printed article using the recycled granulate. The method does not comprise a step of compounding the recycled granulate using a twin screw extruder. The starting article, the shredded product, and the recycle granulate each comprise a fiber reinforced polymer composite. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/380720 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 9/14 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 43/003 (20130101) B29C 64/314 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/10 (20200101) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/06 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124899 | Hamberger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Björn Hamberger (Okemos, Michigan); Sean Johnson (Bedford, Massachusetts); Wajid Waheed Bhat (Haslett, Michigan) |
| ABSTRACT | Enzymes and methods are described herein for manufacturing terpenes, including terpenes. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458762 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1022 (20130101) C12N 9/1085 (20130101) C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/002 (20130101) Original (OR) Class C12P 17/02 (20130101) C12P 17/06 (20130101) Enzymes C12Y 202/01007 (20130101) C12Y 205/01029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124988 | Ding et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong Ding (Idaho Falls, Idaho); Ting He (Idaho Falls, Idaho); Wei Wu (Idaho Falls, Idaho); Yunya Zhang (Idaho Falls, Idaho) |
| ABSTRACT | A method of forming a hydrocarbon product and hydrogen gas comprises introducing CH4 to a positive electrode of an electrochemical cell comprising the positive electrode, a negative electrode, and a proton-conducting membrane between the positive electrode and the negative electrode. The proton-conducting membrane comprises an electrolyte material having an ionic conductivity greater than or equal to about 10−2 S/cm at one or more temperatures within a range of from about 150° C. to about 600° C. A potential difference is applied between the positive electrode and the negative electrode of the electrochemical cell to produce the hydrocarbon product and the hydrogen gas. A CH4 activation system and an electrochemical cell are also described. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311838 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) C25B 3/00 (20130101) Original (OR) Class C25B 9/19 (20210101) C25B 11/077 (20210101) C25B 11/081 (20210101) C25B 13/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125948 | Cates et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Joshua W. Cates (San Francisco, California); Woon-Seng Choong (Oakland, California); Erik Brubaker (Oakland, California) |
| ABSTRACT | A single photon radiation detector is designed for a particular radiation source fluence, such that an incident radiation photon strikes a scintillator monolith, creating scintillation photons, which are amplified by appropriately sized channels of photomultipliers optically coupled to the scintillator monolith. The photomultiplier output is electronically shaped into a corresponding stream of scintillation pulses (otherwise referred to as scintillation photons) that pass through a comparator to produce a bitstream of the detected scintillation photons, which is sampled into a field programmable gate array (FPGA) acting as a giga-sample transceiver to produce time-to-digital conversions, capable of producing an output data stream of 10's-of-giga-samples per second or more. Appropriate design ensures sparsity of scintillation photon arrival, so that each photon in the bitstream corresponds to a single incident scintillation photon. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/486026 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/248 (20130101) G01T 1/20184 (20200501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240126934 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kook In Han (Raleigh, North Carolina); Abhinav GUPTA (Raleigh, North Carolina); Seyedmojtaba NOGHABAEI (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to virtual performance compatibility checking and management for modular construction. In one example, a method includes segmenting boundaries of as-built and as-planned models of a construction element; determining features of each boundary segment of the as-built and as-planned models; determining similarity ratios for matching pairs of boundary segments of the as-built and as-planned models; comparing a total similarity ratio based upon the similarity ratios for matching pairs of boundary segments with a specified threshold; and snapping the as-built model in position in a point cloud in response to the comparison. A system comprising computing or processing circuitry can execute a program or application to implement the similarity/compatibility checking methodology. The similarity/compatibility checking methodology can be implemented within a construction performance modeling and simulation (CPMS) framework. |
| FILED | Saturday, March 05, 2022 |
| APPL NO | 18/280425 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/12 (20200101) Original (OR) Class G06F 30/13 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240128323 | SUNG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSTIY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSTIY OF NEW YORK (Albany, New York) |
| INVENTOR(S) | Woongje SUNG (Niskayuna, New York); Dongyoung KIM (Albany, New York); Adam MORGAN (Newtonville, New York) |
| ABSTRACT | Metal oxide semiconductor field effect transistors (MOSFET) including deep P-wells are disclosed. MOSFETs may include a drift layer disposed over a substrate, and a P-well disposed within the drift layer. The P-well may include a first portion disposed directly over the drift layer, where the first portion includes a first doping concentration. The P-well may also include a second portion separated from the drift layer by the first portion. The second portion may include a second doping concentration distinct from the first doping concentration of the first portion. Additionally, the MOSFET may include an N-source disposed at least partially over the second portion of the P-well, an oxide layer disposed over the N-source and the drift layer, and a gate layer disposed over the oxide layer. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/546853 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/047 (20130101) H01L 29/0607 (20130101) H01L 29/1095 (20130101) Original (OR) Class H01L 29/7802 (20130101) H01L 29/7832 (20130101) H01L 29/66712 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240128471 | Wu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Wenzhuo Wu (West Lafayette, Indiana) |
| ABSTRACT | The electrocatalyst system that is configured to oxidize a methanol molecule using piezo-electrocatalysis includes a substrate and a piezoelectric semiconductor. The piezoelectric semiconductor is coupled to the substrate. The piezoelectric semiconductor includes a nanostructured semiconducting zinc oxide (ZnO) catalyst. The nanostructured semiconducting zinc oxide catalyst is characterized by a UV-ozone (UV-O3) treatment process. The electrocatalyst system may be provided in a methanol fuel cell. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/379738 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8882 (20130101) H01M 4/9016 (20130101) Original (OR) Class H01M 4/9075 (20130101) H01M 8/1011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240128505 | LAVALLO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California); UCHICAGO ARGONNE, LLC (CHICAGO, Illinois) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California); UCHICAGO ARGONNE, LLC (CHICAGO, Illinois) |
| INVENTOR(S) | Vincent LAVALLO (Riverside, California); Anton TOMICH (Riverside, California); Christopher S. JOHNSON (Argonne, Illinois); Lei CHENG (Naperville, Illinois); Eungje LEE (Lemont, Illinois); Jehee PARK (Woodridge, Illinois); Jihyeon GIM (Naperville, Illinois); Ethan Phillip KAMPHAUS (Chicago, Illinois) |
| ABSTRACT | An anode in an electrochemical cell includes an anode active material comprising sodium and a solid electrolyte interphase (SEI) layer disposed on the anode active material. The SEI layer includes reduction products of an electrolyte solvent and is free of degradation products derived from dissolved anions of an electrolyte salt. The electrolyte solvent and the electrolyte salt are present in an electrolyte of the electrochemical cell. The SEI layer does not include a fluorine content greater than 5 wt. %. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488971 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/044 (20130101) H01M 4/381 (20130101) H01M 10/26 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240128742 | Sampayan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Opcondys, Inc. (Manteca, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen E. Sampayan (Manteca, California); Kristin C. Sampayan (Manteca, California) |
| ABSTRACT | Devices, methods and techniques related to the suppression of electrical transients are disclosed. In one example aspect, an electrical transient protection device includes a sensor configured to monitor power transmission on a transmission line of a power system, a controller configured to generate a control signal in response to a detection of one or more electrical transients by the sensor, and a controller transient suppression unit comprising at least a switch that exhibits a changeable impedance. The controllable transient suppression unit configured to impose a load to the power system. The load has a substantially same impedance as a characteristic impedance associated with a part of the power system. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/485079 |
| CURRENT CPC | Emergency Protective Circuit Arrangements H02H 1/0007 (20130101) H02H 9/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240128864 | Ye et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Zichao Ye (El Cerrito, California); Robert Pilawa-Podgurski (Alameda, California) |
| ABSTRACT | A switched-capacitor (SC) network in an SC converter is controlled to operate at varying resonant modes to achieve high conversion ratio efficiency, at a low circuit component count. These power converters are suited to numerous application areas including improving energy efficiency of data centers. A family of resonant switched capacitor (SC) converters with multiple operating phases are presented “Multi-Resonant SC Converters”. Described in detail are an 8-to-1 Multi-Resonant-Doubler (MRD) converter and a 6-to-1 Cascaded Series-Parallel (CaSP). The topology of these converters make them amenable to combining like units in parallel toward reaching higher power levels. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/320879 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/0043 (20210501) H02M 1/0058 (20210501) H02M 1/0095 (20210501) H02M 3/07 (20130101) Original (OR) Class H02M 3/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240128918 | Allison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Quest Renewables, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darby Allison (Atlanta, Georgia); Norman Painter Findley, IV (Atlanta, Georgia); James Keane (Atlanta, Georgia); Lauren Terris (Arvada, Colorado) |
| ABSTRACT | Apparatuses, systems, and methods for providing wind-resilient solar panel racking structures. The solar panel racking structures having first and second upper panel mount assemblies, first and second base assemblies, and first and second sets of solar panels. The upper panel mount assemblies and base assemblies linked by cross-braces and together forming a tent-like structure for supporting the solar panels at an angle. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335704 |
| CURRENT CPC | Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/10 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240128922 | Allison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Quest Renewables, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darby Allison (Atlanta, Georgia); Norman Painter Findley, IV (Atlanta, Georgia); James Keane (Atlanta, Georgia); Lauren Terris (Arvada, Colorado) |
| ABSTRACT | Apparatuses, systems, and methods for providing wind-resilient solar panel array fields. The solar panel array fields may have perimeter solar panel racking structures and core solar panel racking structures. The perimeter solar panel racking structures forming at least a perimeter around the core solar panel racking structures to help shield core solar panel racking structures and reduce wind forces applied to the core solar panel racking structures. The perimeter solar panel racking structures may be rigid and may be more wind tolerant than the core solar panel racking structures. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335761 |
| CURRENT CPC | Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/32 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240129045 | Namazi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Qunnect, Inc. (Brooklyn, New York) |
| ASSIGNEE(S) | Qunnect, Inc. (Brooklyn, New York) |
| INVENTOR(S) | Mehdi Namazi (Brooklyn, New York); Mael Flament (Brooklyn, New York); Yang Wang (New York, New York); Alexander Craddock (Brooklyn, New York); Rourke Sekelsky (Brooklyn, New York); Anita Richardson (Brooklyn, New York) |
| ABSTRACT | Systems and methods for generating an entangled pair of bichromatic photons are described. The system includes an atomic vapor cell containing atoms of an atomic species located within beam paths of a first and second laser beam. The first and In second laser beams are tuned to first and second wavelengths that are resonant with first and second atomic transitions of the atomic species such that the first and second laser beams cause a four-wave mixing process within the atomic vapor cell. As a result of the four-wave mixing process, entangled photon pairs having a third and fourth wavelength are generated and output from the atomic vapor cell. The first and second wavelengths may be selected to create electromagnetically-induced transparency (BIT) within the atomic vapor cell, the BIT creating a transparent medium within the atomic vapor cell at the third wavelength, improving spectral brightness and/or photon linewidths. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 18/274865 |
| CURRENT CPC | Transmission H04B 10/70 (20130101) Original (OR) Class H04B 10/503 (20130101) H04B 10/572 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240130145 | Tombs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Energy Materials Corporation (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Nathaniel Tombs (Rochester, New York); Scott Kenneth Christensen (North Chili, New York) |
| ABSTRACT | A bifacial photovoltaic structure includes a transparent substrate, a perovskite absorber layer overlaying the substrate, a transparent first composite conductor interposed between the substrate and the perovskite absorber layer, and a transparent second composite conductor disposed over the perovskite absorber layer. The first composite conductor includes a first set of metal lines, and a first conducting layer provided in contact with the metal lines, wherein the first set of metal lines is characterized by a first set of dimensions and a first metallic composition. The second composite conductor includes a second conducting layer, and a second set of metal lines provided in contact with the second conducting layer, wherein the second set of metal lines is characterized by a second set of dimensions and a second metallic composition. The dimensions and/or compositions of the first and second composite conductors are different. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/375129 |
| CURRENT CPC | Organic electric solid-state devices H10K 30/10 (20230201) H10K 30/50 (20230201) Original (OR) Class H10K 30/82 (20230201) H10K 30/85 (20230201) H10K 30/86 (20230201) H10K 39/12 (20230201) H10K 71/611 (20230201) H10K 85/50 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240130153 | Forrest et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan); Haonan ZHAO (Ann Arbor, Michigan); Jongchan KIM (Ann Arbor, Michigan) |
| ABSTRACT | Disclosed are methods, designs and materials for extending the device operational lifetime of the phosphorescent organic light emitting devices (OLEDs) such as thermally activated delayed fluorescence (TADF) OLEDs. Applying a graded cohost or co-doped emission layer (EML) in the organic layers, both charge transport and charge balance can be precisely engineered to generate a uniform exciton/exciplex profile, preventing the early deaths due to the dense hot-excited states in the device. This invention is aimed at the short lifetime problem of the high efficient phosphorescent OLEDs and TADF OLEDs, especially in the white, blue and deep blue applications. |
| FILED | Wednesday, September 20, 2023 |
| APPL NO | 18/470908 |
| CURRENT CPC | Organic electric solid-state devices H10K 50/15 (20230201) Original (OR) Class H10K 50/125 (20230201) H10K 50/181 (20230201) H10K 59/80516 (20230201) H10K 2102/302 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240124134 | German et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia); United States of America as represented by the Administrator of NASA (Washington DC, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Joseph German (Atlanta, Georgia); Daniel Sagan (Atlanta, Georgia); Jason Welstead (Atlanta, Georgia); Siena Whiteside (Atlanta, Georgia) |
| ABSTRACT | A vertical take-off or landing (VTOL) aircraft is disclosed that includes a propulsion system comprising at least four tilting propulsion assemblies and two or more lifting propulsion assemblies. Actuation of the tilting mechanisms can convert the aircraft from a hover configuration, in which all propellers produce thrust generally upward to counteract the aircraft's weight, to a forward flight configuration, in which the four or more tilting propellers produce thrust generally in a forward direction parallel to the fuselage to overcome drag in cruise flight and the lifting propellers produce no thrust or a level of thrust generally less than that required in the hover configuration. |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/487533 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/60 (20190201) B60L 2200/10 (20130101) Aeroplanes; Helicopters B64C 27/26 (20130101) B64C 27/28 (20130101) Original (OR) Class B64C 27/78 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 2221/00 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 10/20 (20230101) B64U 50/13 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124994 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Space Systems International, Inc. (Windsor Locks, Connecticut) |
| ASSIGNEE(S) | Hamilton Sundstrand Space Systems International, Inc. (Windsor Locks, Connecticut) |
| INVENTOR(S) | Hailing Wu (Glastonbury, Connecticut); Luke Blaskewicz (Monroe, Connecticut); Walter T. Schmidt (Marlborough, Connecticut); Robert J. Roy (West Springfield, Massachusetts); Phillip Baker (Colchester, Connecticut); Galen W. Kulp (Manchester, Connecticut) |
| ABSTRACT | In accordance with at least one aspect of this disclosure, a method includes flushing a cell stack for a predetermined amount of time as a function of an amount of combustible gas remaining in the cell stack. The method also includes operating a cell stack for a predetermined amount of time, then shutting down the cell stack and ceasing operation of the cell stack for a predetermined amount of time. Flushing occurs after shutting down a cell stack power supply. The method further includes restarting operation of the cell stack after flushing. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966433 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 15/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125189 | SHERRILL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristopher V. SHERRILL (Pasadena, California); Jacob F. TIMS (Pasadena, California); Scott J. MORELAND (Pasadena, California) |
| ABSTRACT | Systems and methods for driving and steering of a robot, or mobile vessel, for operation in a downhole pipe of an oil/gas/water well are presented. According to one aspect, the mobile vessel includes a plurality of wheels arranged outwardly from the mobile vessel so that each wheel may contact the inner wall of the casing. According to another aspect, the plurality of wheels may include respective wheel-centerlines that intersect the centerline of the casing that is at an offset from a centerline of the mobile vessel. The plurality of wheels includes at least two drive wheels and at least one passive wheel. According to a further aspect, the drive wheels are configured to rotate about their respective wheel-centerlines to steer the mobile vessel during traversal of the casing. In one case, the mobile vessel includes two drive and steering wheels and one passive wheel. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 18/277351 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 23/001 (20200501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240125649 | Hosseini |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Seyedeh Sona Hosseini (Pasadena, California) |
| ABSTRACT | Ultra-miniature spatial heterodyne spectrometers (SHSs) are presented. Ultra-miniature SHSs in accordance with the invention, comprise a beam-splitter and gratings configured to generate a fringe pattern for spectroscopic detection. Many embodiments include input optics and a sensor and are configured in a way to omit collimating optics and imaging optics from the SHS. Compared to conventional SHSs known in the art, the present invention enables fewer parts, significantly smaller and lighter SHSs, are more efficient and robust, and require less maintenance. Many embodiments are field-deployable, in that such embodiments can be deployed for hand held use in real-world or remote activities outside of research or diagnostic facilities. |
| FILED | Friday, August 04, 2023 |
| APPL NO | 18/365821 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0202 (20130101) G01J 3/0208 (20130101) G01J 3/0256 (20130101) Original (OR) Class G01J 3/0272 (20130101) G01J 3/0291 (20130101) G01J 3/443 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240129027 | BODE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Atlas Space Operations, Inc. (Traverse City, Michigan) |
| ASSIGNEE(S) | Atlas Space Operations, Inc. (Traverse City, Michigan) |
| INVENTOR(S) | Brad Arnold BODE (Pacific Palisades, California); Kyle Stephen POLICH (Los Angeles, California) |
| ABSTRACT | The present application relates to techniques for proactively monitoring and detecting failures associated with downlinking data during satellite passes. In some embodiments, first data representing a performance of a hardware device during a satellite pass may be obtained and performance metrics may be computed based on the first data. Second data may be generated based on the performance metrics and a first machine learning model may be used to determine changepoints within the second data and times associated with each changepoint. A second machine learning model may be used to determine a likelihood that the satellite pass will be successful based on at least one of the quantity of changepoints or the times associated with each changepoint, and a quality of service (QoS) score of a client may be updated based on the likelihood. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363583 |
| CURRENT CPC | Transmission H04B 7/18517 (20130101) H04B 7/18519 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20240124670 | BERTINO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Massimo BERTINO (Glen Allen, Virginia); Tristan MOON (Richmond, Virginia); Dustin CLIFFORD (Richmond, Virginia); Jonathan KO (West Bethesda, Maryland); Gordon WALLER (Washington, District of Columbia) |
| ABSTRACT | An open cell foam, and particularly aerogels or other foams, having an inorganic, hydraded phase change material (PCM) embedded within pores or cells or a network within the foam have fire retardant, fire resistant and thermal insulating properties. These composite materials are preferably monolithic in character, and are mechanically robust allowing for example the attachment of nails or screws. With the PCM distributed throughout the open cell foam, the composite material has a wide array of applications including providing thermal, fire resistant, and fire retardant uses in battery containers, in automotives and other vehicles, etc. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/376564 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/0009 (20130101) Original (OR) Class C08J 9/224 (20130101) C08J 9/286 (20130101) C08J 2201/0502 (20130101) C08J 2205/05 (20130101) C08J 2205/026 (20130101) C08J 2207/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/14 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 59/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240124716 | LIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhibin LIN (Fargo, North Dakota); Xingyu WANG (Fargo, North Dakota); Hong PAN (Fargo, North Dakota) |
| ABSTRACT | The invention relates to a first curable coating composition comprising a first layer comprising at least one epoxy resin and at least one hybrid nanofiller, and a second layer comprising carbon nanotubes (CNTs). This invention also relates to a second curable coating composition comprising at least one hybrid nanofiller; at least one epoxy resin; and at least one curing agent. This invention also relates to methods of making the curable coating compositions. This invention also relates to methods for coating the surface of a metallic coated substrate. |
| FILED | Friday, July 07, 2023 |
| APPL NO | 18/348866 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 5/002 (20130101) C09D 5/1662 (20130101) Original (OR) Class C09D 7/61 (20180101) C09D 7/67 (20180101) C09D 163/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240124527 | Boutjdir et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia); New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohamed Boutjdir (Brooklyn, New York); Timothy Jude Cardozo (New York, New York) |
| ABSTRACT | Disclosed herein, are decoy peptides or polypeptides capable of neutralizing and/or inhibiting the binding of anti-Ro antibodies to a hERG potassium channel extracellular pore region, and pharmaceutical compositions containing the decoy peptides or polypeptides and methods of use. |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/487767 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Peptides C07K 14/00 (20130101) Original (OR) Class C07K 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20240126680 | KEPPEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David KEPPEL (Mountain View, California); David OZOG (Ashland, Massachusetts); Lawrence STEWART (Wayland, Massachusetts); Sri Raj PAUL (Austin, Texas); Md RAHMAN (Bee Cave, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David KEPPEL (Mountain View, California); David OZOG (Ashland, Massachusetts); Lawrence STEWART (Wayland, Massachusetts); Sri Raj PAUL (Austin, Texas); Md RAHMAN (Bee Cave, Texas) |
| ABSTRACT | Various examples relate to apparatuses, devices, methods and computer programs for allocating memory. An apparatus comprises interface circuitry, machine-readable instructions, and processor circuitry to execute the machine-readable instructions to process instructions of a software application of a local processing element participating in a partitioned global address space, allocate, upon processing an instruction for allocating memory on a symmetric heap being used across a plurality of processing elements participating in the partitioned global address space, memory on the symmetric heap, wherein, if the instruction for allocating memory indicates that memory is to be allocated with a variable size, the memory allocated on the symmetric heap has a size that is specific for the local processing element. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/391714 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0223 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240127092 | KING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Atom Computing Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan KING (Oakland, California); Benjamin BLOOM (Berkeley, California); Brian LESTER (Berkeley, California) |
| ABSTRACT | The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation. |
| FILED | Wednesday, September 20, 2023 |
| APPL NO | 18/470604 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/33 (20130101) Optical Computing Devices; G06E 3/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240123471 | Bombaugh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Bombaugh (Burke, Virginia); Tuan A. Le (Fairfax, Virginia); Charles P. McLellan (Fairfax, Virginia); Christopher M. Stratton (Springfield, Virginia) |
| ABSTRACT | A high throughput sorting device is disclosed. The device includes a first sorter and a second sorter, each of the first and second sorters having a plurality of cells each configured to support, carry, and deposit an item. The device can also include at least one shared chute extending below a portion of the first sorter and a portion of the second sorter. The at least one chute can be configured to receive an item deposited by each of the plurality of cells and transport the item to an endpoint. The device can also include a base configured to support the at least one shared chute and the first and second sorters. |
| FILED | Thursday, December 28, 2023 |
| APPL NO | 18/399477 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/02 (20130101) B07C 3/008 (20130101) B07C 3/08 (20130101) B07C 3/18 (20130101) B07C 5/36 (20130101) Original (OR) Class Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 47/38 (20130101) B65G 47/44 (20130101) B65G 47/967 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240127976 | Fest |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Otto Fest (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Otto Fest (Tucson, Arizona) |
| ABSTRACT | A single movement display meter includes a display input wherein the display input receives and transmits a display input signal containing information relative to only one property. A digital display is positioned to receive the display input signal and represent the digital input signal within a display, wherein the digital display has a front surface. A display filter mounts on the front surface of the digital display. A hub includes an input connector connectable to one or more wires to receive a hub input signal. A signal modification module connected to the input connector is capable of modifying the hub input signal to output the display input signal. A hub output communicates with the display input to transmit the display input signal. |
| FILED | Saturday, June 04, 2022 |
| APPL NO | 17/832626 |
| CURRENT CPC | Nuclear Power Plant G21D 1/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240130250 | WARNER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PATRICK R. WARNER (Hampstead, Maryland); JUSTIN C. HACKLEY (Catonsville, Maryland); SHAWN A. KEEBAUGH (Annapolis, Maryland); AURELIUS L. GRANINGER (Sykesville, Maryland) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | PATRICK R. WARNER (Hampstead, Maryland); JUSTIN C. HACKLEY (Catonsville, Maryland); SHAWN A. KEEBAUGH (Annapolis, Maryland); AURELIUS L. GRANINGER (Sykesville, Maryland) |
| ABSTRACT | A Josephson junction (JJ) device is disclosed that includes a first superconductor structure having a bottom superconductor arm portion and a second superconductor structure having a top superconductor arm portion disposed substantially orthogonal to the bottom superconductor arm portion and overlapping the bottom superconductor arm portion in a JJ operation region. The JJ device further includes a dielectric material layer acting as a tunnel barrier disposed between the bottom superconductor arm portion and the top superconductor arm portion in the JJ operation region to form an operating JJ. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 17/967584 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/12 (20130101) H01L 39/025 (20130101) Original (OR) Class H01L 39/223 (20130101) H01L 39/2493 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, April 18, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240418.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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