FedInvent™ Patent Applications
Application Details for Thursday, May 09, 2024
This page was updated on Tuesday, June 18, 2024 at 02:21 PM GMT
Department of Health and Human Services (HHS)
| US 20240148291 | Valdes et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pablo Valdes (Phoenix, Arizona); Frederic Leblond (Montreal, Canada); Keith D. Paulsen (Hanover, New Hampshire); Brian Campbell Wilson (Toronto, Canada); David W. Roberts (Lyme, New Hampshire); Michael Jermyn (Longueuil, Canada) |
| ABSTRACT | An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery. |
| FILED | Monday, January 01, 2024 |
| APPL NO | 18/401664 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/07 (20130101) A61B 1/00009 (20130101) A61B 1/042 (20130101) A61B 1/043 (20130101) A61B 1/000094 (20220201) A61B 1/00165 (20130101) A61B 1/00193 (20130101) A61B 1/00194 (20220201) A61B 1/0646 (20130101) A61B 1/0669 (20130101) A61B 1/0684 (20130101) A61B 1/3132 (20130101) A61B 5/055 (20130101) A61B 5/0071 (20130101) A61B 5/0077 (20130101) A61B 5/1459 (20130101) A61B 5/1495 (20130101) A61B 5/7264 (20130101) A61B 5/14546 (20130101) A61B 5/14553 (20130101) A61B 5/14556 (20130101) Original (OR) Class Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0229 (20130101) G01J 3/1256 (20130101) G01J 3/2823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148304 | Leuthardt |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Leuthardt (St. Louis, Missouri) |
| ABSTRACT | A brain computer interface (BCI) system includes an electroencephalogram (EEG) headset and a computing device communicatively coupled to the EEG headset. The computing device includes a memory, a processor and a display device. The memory stores instructions that, when executed by the processor, cause the processor to monitor, using the EEG headset, current extrinsic network activity and current intrinsic network activity of a patient, generate a current depression index based on the relationship between the current extrinsic network activity and the current intrinsic network activity, and display, on the display device, a representation of the relationship between the current depression index and a baseline depression index previously generated for the patient. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405437 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) A61B 5/165 (20130101) A61B 5/316 (20210101) Original (OR) Class A61B 5/369 (20210101) A61B 5/4848 (20130101) A61B 5/7405 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148523 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhi Yang (Minneapolis, Minnesota); Anh Tuan Nguyen (Minneapolis, Minnesota); Diu Khue Luu (Minneapolis, Minnesota) |
| ABSTRACT | A neurostimulator incorporating a novel chip design that uses the principle of redundant signal crossfiring to overcome electronic component mismatch error in general and transistor mismatch error in particular, to yield superior quality neurostimulation signal generation, useful in enhancing the bidirectional human-machine interface in prosthesis operation for the restoration of somatosensation for an amputee; and an improvement thereof additionally comprising a digital-to-analog converter device, that includes a number of unit cells, each unit cell being associated with a unit cell size indicating manufacturing specifications of the unit cell, and that further includes a plurality of switches, each being coupled to a component, and an output electrode coupled to the plurality of switches, and wherein the digital-to-analog converter device is configured to output an output signal at the output electrode. |
| FILED | Tuesday, December 26, 2023 |
| APPL NO | 18/396610 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) Original (OR) Class A61F 2/583 (20130101) A61F 2002/6827 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148658 | LEE et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
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| INVENTOR(S) | Daeyeon LEE (Wynnewood, Pennsylvania); Yun Kee JO (Philadelphia, Pennsylvania); Robert Leon MAUCK (Philadelphia, Pennsylvania); George R. DODGE (Philadelphia, Pennsylvania) |
| ABSTRACT | A composition, comprising: a plurality of mechanically-activated microcapsules; a mechanically-activated microcapsule defining a shell and an exterior surface; and the mechanically-activated microcapsule comprising one or more adhesion groups disposed Non the exterior surface of the mechanically-activated microcapsule, the one or more adhesion groups being configured to effect a covalent interaction, a non-covalent interaction, or both between the one or more adhesion groups and a matrix material, the covalent interaction, the non-covalent interaction, or both adhering the mechanically-activated microcapsule to the matrix material. Also provided are related methods and related articles. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/552711 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) A61K 9/5031 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148666 | CHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Qiang CHENG (Dallas, Texas); Tuo WEI (Dallas, Texas); Daniel J. SIEGWART (Dallas, Texas) |
| ABSTRACT | The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/534974 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 48/0033 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148679 | GUO |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
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| INVENTOR(S) | Deliang GUO (Dublin, Ohio) |
| ABSTRACT | Disclosed herein are compounds, compositions, and methods for inhibiting DGAT1 and DGAT2. Also disclosed are kits comprising DGAT1 and DGAT2 inhibitors. The compounds, compositions, and methods can be used to treat a subject with cancer, such as liver cancer. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/769512 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/196 (20130101) Original (OR) Class A61K 31/4545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148684 | OMARY et al. |
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| FUNDED BY |
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| APPLICANT(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey); REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey); REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, New Jersey) |
| INVENTOR(S) | Bishr OMARY (New Brunswick, New Jersey); Jordan Adam SHAVIT (Ann Arbor, Michigan) |
| ABSTRACT | The invention provides a method for treating or ameliorating the clinical manifestations of congenital erythropoietic porphyria in an animal (e.g. a human) by administering a retinoid to the animal. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 18/278904 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/203 (20130101) Original (OR) Class A61K 31/409 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148688 | JAMIESON et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Catriona JAMIESON (San Diego, California); Leslie CREWS ROBERTSON (San Diego, California); Michael BURKART (San Diego, California); Larisa BALAIAN (San Diego, California); Phoebe MONDALA (San Diego, California); Cayla MASON (San Diego, California); Raymond H. DIEP (San Diego, California); James LACLAIR (San Diego, California); Thomas WHISENANT (San Diego, California); Warren C. CHAN (San Diego, California); Inge VAN DER WERF (San Diego, California); Peggy WENTWORTH (San Diego, California); Wenxue MA (San Diego, California) |
| ABSTRACT | In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 18/275388 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) Original (OR) Class A61K 31/506 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148691 | Sorokin et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
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| INVENTOR(S) | Andrey Sorokin (Whitefish Bay, Wisconsin); Doris Benbrook (Oklahoma City, Oklahoma) |
| ABSTRACT | The present invention provides methods of reducing, inhibiting, preventing and treating vascular diseases. More specifically, the present disclosure provides methods of treating vascular diseases with the modulator of p66Shc signaling SHetA2. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 18/546633 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/382 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148710 | Oguro |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hideyuki Oguro (West Hartford, Connecticut) |
| ABSTRACT | Disclosed are compounds for use in modulating a mobilization of hematopoietic stem and progenitor cells (HSPCs) or hematopoietic stem cells (HSCs) from the bone marrow to the peripheral blood in a subject; wherein the compound inhibits the activity of cytochrome P450 family 7 subfamily B member 1 (CYP7B1 inhibitor). |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491536 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/395 (20130101) A61K 31/444 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/575 (20130101) A61K 31/4174 (20130101) A61K 38/19 (20130101) A61K 38/27 (20130101) A61K 38/45 (20130101) A61K 38/193 (20130101) A61K 38/195 (20130101) A61K 38/196 (20130101) A61K 38/202 (20130101) A61K 38/1866 (20130101) A61K 38/1891 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148716 | Zhou et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Pei Zhou (Durham, North Carolina); Jiyong Hong (Durham, North Carolina) |
| ABSTRACT | This invention relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to translesion synthesis (TLS) pathway. More particularly, this disclosure relates to small molecule inhibitors of TLS, methods of inhibiting TLS pathway with these compounds, and methods of treating diseases related to the TLS pathway. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/473202 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4706 (20130101) Original (OR) Class A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148722 | BINDER et al. |
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| APPLICANT(S) | Biohaven Therapeutics Ltd. (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randall J. BINDER (Philadelphia, Pennsylvania); Marianne CARLSEN (Yardley, Pennsylvania); Xiao JIN (King of Prussia, Pennsylvania); Mark E. MCDONNELL (Lansdale, Pennsylvania); Allen B. REITZ (, None); Camille REMEUR (Toulouse, France); Eric STROBEL (Warrington, Pennsylvania); Huji TURDI (Yardley, Pennsylvania) |
| ABSTRACT | The present invention relates to compounds that bind to TDP-43 and may have a therapeutic effect in treating a human disease, such as amyotrophic lateral sclerosis, frontotemporal lobar degeneration, hippocampal sclerosis of aging, chronic traumatic encephalopathy, inclusion body myositis, Alzheimer's disease, and/or Alzheimer's disease related disorders. |
| FILED | Sunday, February 20, 2022 |
| APPL NO | 18/546285 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) A61K 31/428 (20130101) A61K 31/443 (20130101) A61K 31/444 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/5377 (20130101) A61K 38/06 (20130101) Heterocyclic Compounds C07D 213/74 (20130101) C07D 401/04 (20130101) C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 413/04 (20130101) C07D 413/14 (20130101) C07D 417/04 (20130101) C07D 451/04 (20130101) C07D 487/04 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148754 | Pan et al. |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deng Pan (Chicago, Illinois); Masha Kocherginsky (Chicago, Illinois); Suzanne D. Conzen (Park Ridge, Illinois) |
| ABSTRACT | Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541675 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 31/357 (20130101) A61K 31/567 (20130101) A61K 31/575 (20130101) Original (OR) Class A61K 31/4745 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 39/3955 (20130101) A61K 45/06 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148757 | GAN et al. |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); KADMON CORPORATION LLC (New York, New York) |
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| INVENTOR(S) | Boyi GAN (Houston, Texas); Kellen OLSZEWSKI (Brooklyn, New York); Chao MAO (Houston, Texas) |
| ABSTRACT | The present disclosure provides methods for treating cancer comprising administering to a subject in need thereof a therapeutically effective amount of a dihydroorotate dehydrogenase (DHODH) inhibitor, wherein the cancer has an altered glutathione peroxidase 4 (GPX4) expression as compared to a control sample. The present disclosure also provides methods of treating a subject with a dihydroorotate dehydrogenase (DHODH) inhibitor where the subject's GPX4 expression is low as compared to a control sample or with a DHODH inhibitor and a ferroptosis inducer where the subject's GPX4 expression is high as compared to a control sample. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/548678 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/42 (20130101) A61K 31/47 (20130101) A61K 31/277 (20130101) A61K 31/381 (20130101) A61K 31/437 (20130101) A61K 31/517 (20130101) A61K 31/655 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57496 (20130101) G01N 2333/90206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148764 | Xu et al. |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Xu (Ann Arbor, Michigan); Kezhong Zhang (DETROIT, Michigan); Xiubin Liang (Ann Arbor, Michigan); Yuqing Eugene Chen (Ann Arbor, Michigan) |
| ABSTRACT | This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical agents which function as inhibitors of sodium-glucose cotransporter 1 (SGLT-1) activity. The invention further relates to methods of treating and/or ameliorating symptoms related to cystic fibrosis-related liver disease and diseases characterized with increased SGLT-1 activity, increased endoplasmic reticulum (ER) stress response, and/or increased hepatic inflammation. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 18/280293 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7034 (20130101) Original (OR) Class A61K 31/7048 (20130101) A61K 31/7056 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148765 | Walsh et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Kenneth Walsh (Charlottesville, Virginia); Soichi Sano (Hikone City, Japan) |
| ABSTRACT | Provided are methods for treating and/or preventing genotoxic stress-induced cardiac toxicity, which in some embodiments include administering to a subject an effective amount of an inhibitor of t-CH, of neutrophil activation, of neutrophil migration, or any combination thereof. In some embodiments, the genotoxic stress-induced cardiac toxicity results from exposure to one or more anti-tumor and/or anti-cancer therapies, including but not limited to treatment with one or more chemotherapeutics (e.g., doxorubicin) and/or treatment with radiation. In some embodiments, the genotoxic stress-induced cardiac toxicity, the chemotherapy-induced cardiac toxicity, the chemotherapy-induced heart damage, and/or the chemotherapy-induced reduction in cardiac function is characterized by a reduction in cardiac contractility, a thinning of a ventricular wall, a reduction in cardiomyocyte size, or any combination thereof. Also provided are methods for predicting heart failure in subjects previously exposed to a genotoxic agent such as but not limited to a chemotherapeutic by detecting the presence of t-CH in the subject. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 18/281528 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 31/704 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148781 | Baker et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Baker (Austin, Texas); Nikita Patil (Austin, Texas) |
| ABSTRACT | The present invention describes compositions and methods for treatment of metabolic diseases and disorders, such as non-alcoholic fatty liver disease (NAFLD), and circadian rhythm-related disorders. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501504 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/737 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148791 | June et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl H. June (Merion Station, Pennsylvania); Regina M. Young (Bryn Mawr, Pennsylvania); Shelley L. Berger (Wayne, Pennsylvania); Charly R. Good (Springfield, Pennsylvania); M. Angela Aznar Gomez (Philadelphia, Pennsylvania); Shunichiro Kuramitsu (Nagoya, Japan) |
| ABSTRACT | The present disclosure provides modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising a modification in an endogenous gene locus encoding SOX and/or ID3. Methods for assessing and treating T cell dysfunction are also provided. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 18/549252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/4632 (20230501) A61K 39/464499 (20230501) A61K 2239/13 (20230501) A61K 2239/17 (20230501) A61K 2239/21 (20230501) A61K 2239/22 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2740/15043 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148792 | Pan |
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| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dao Pan (Cincinnati, Ohio) |
| ABSTRACT | Disclosed are delivery vectors for the delivery of nucleic acid transcription products and methods of using same. The disclosed vectors may be either contain a single transcription unit (TU) (“single-cassette”) or two transcription units (TUs) (“dual-cassette”). The delivery vectors employ a cytomegalovirus (CMV) core fragment (cC element) that may be oriented in either a forward or reverse orientation to improve vector transcription efficiency, which is located downstream of a TU in a single-cassette system, or placed between two TUs in a dual cassette system. The disclosed delivery vectors may be used for the delivery of therapeutic or non-therapeutic proteins, peptides, or non-coding, and may be used both in vitro and in vivo. |
| FILED | Friday, July 21, 2023 |
| APPL NO | 18/224735 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2710/16143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148800 | Aroian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raffi Van Aroian (Worcester, Massachusetts); Gary R. Ostroff (Worcester, Massachusetts) |
| ABSTRACT | Compositions and methods for treating or reducing the severity of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a composition comprising isolated native, bioactive nematicidal crystals formed from a single type of nematicidal crystal protein. The isolated native, bioactive nematicidal crystals are substantially free of any bacterial spores or host bacterial proteins, other than nematicidal crystal protein in the form of a crystal. Methods for making isolated native, bioactive nematicidal crystals are also described. The crystal proteins may be full length, truncated, variant, or sub-variant Cry proteins. Examples of crystal proteins include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485796 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/48 (20130101) A61K 35/741 (20130101) Original (OR) Class A61K 38/164 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148831 | LI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (Norman, Oklahoma) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (Norman, Oklahoma) |
| INVENTOR(S) | Tiangang LI (Edmond, Oklahoma) |
| ABSTRACT | A method of treating a cholestasis liver condition in a subject by administering to the subject a first compound and a second compound, wherein the first compound is a fibroblast growth factor 19 (FGF19) analogue, and/or a bile acid-activated farnesoid x receptor (FXR) agonist, and the second compound is an apical sodium-dependent bile acid transporter (ASBT) inhibitor. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/501014 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1825 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148832 | McAlpine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cameron McAlpine (Boston, Massachusetts); Filip K. Swirski (Swampscott, Massachusetts); Rudolph E. Tanzi (Milton, Massachusetts) |
| ABSTRACT | Described herein are compositions and methods targeting IL-3 signaling for reducing Alzheimer's disease (AD)-related pathology. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 18/274677 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/202 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148855 | ZHUANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NE1 Inc. (New York, New York); United States Department of Health and Human Services and the National Institute of Health (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhengping ZHUANG (Bethesda, Maryland); Herui WANG (Mclean, Virginia); Juan YE (Bethesda, Maryland); Bin LU (Falls Church, Virginia) |
| ABSTRACT | The present disclosure generally relates to a personalized cancer vaccine having attenuated cancer cells transfected with at least one expression construct. The expression construct is capable of secretory expression of an antigenic polypeptide that could be derived from a protein from a virus. The personalized tumor vaccine, when administered to a subject in need thereof, is effective to activate an immune response. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 18/550895 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 39/215 (20130101) A61K 39/245 (20130101) A61K 45/06 (20130101) A61K 2039/53 (20130101) A61K 2039/54 (20130101) A61K 2039/505 (20130101) A61K 2039/585 (20130101) A61K 2039/5152 (20130101) A61K 2039/5156 (20130101) A61K 2039/55555 (20130101) A61K 2039/55583 (20130101) Peptides C07K 16/2878 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/16034 (20130101) C12N 2760/16134 (20130101) C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148862 | Falo, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Louis D. Falo, JR. (Wexford, Pennsylvania); Adriana Teresita Larregina De Morelli (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods are provided for promoting, reducing, or desensitizing various immune responses by delivery of sub-immunogenic doses of an allergen, alone or with other agents, or by delivery of antigens and adjuvants to a cutaneous microenvironment of a subject. Microneedle arrays can be used in connection with this delivery. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/453114 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) A61K 38/19 (20130101) A61K 38/046 (20130101) A61K 39/001 (20130101) A61K 39/35 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/54 (20130101) A61K 2039/545 (20130101) A61K 2039/555 (20130101) A61K 2039/577 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148864 | Zanoni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Ivan Zanoni (Brookline, Massachusetts); Francesco Borriello (Arlington, Massachusetts); Ofer Levy (Cambridge, Massachusetts); David J. Dowling (Milton, Massachusetts) |
| ABSTRACT | Provided herein are adjuvantation systems comprising fungal polysaccharides for use in Beta coronavirus (e.g., MERS-CoV, SARS-CoV-1, or SARS-CoV-2) and influenza (influenza A virus and influenza B virus) vaccines and immunogenic compositions comprising the adjuvantation system and a Beta coronavirus or influenza virus antigen. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 18/281540 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 39/145 (20130101) A61K 39/215 (20130101) A61K 2039/55583 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148870 | Hwang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael S. Hwang (Seattle, Washington); Jacqueline Douglass (Baltimore, Maryland); Emily Han-Chung Hsiue (Baltimore, Maryland); Kenneth W. Kinzler (Frankford, Delaware); Brian J. Mog (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Alexander H. Pearlman (Baltimore, Maryland); Bert Vogelstein (Baltimore, Maryland); Shibin Zhou (Owings Mills, Maryland) |
| ABSTRACT | Provided herein are immune cells and methods of use, wherein the immune cells include a chimeric antigen receptor (CAR), wherein the CAR comprises an extracellular antigen binding domain that binds specifically to a first epitope; and an inhibitory chimeric antigen receptor (iCAR), wherein the iCAR comprises an extracellular antigen binding domain that binds specifically to a second epitope, wherein the immune cell is activated when the immune cells binds to the first epitope and does not bind to the second epitope; and wherein the immune cell is inactivated when the immune cell binds to the first and second epitopes. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 18/281471 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464412 (20230501) Original (OR) Class A61K 2239/21 (20230501) A61K 2239/22 (20230501) A61K 2239/28 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 16/2803 (20130101) C07K 16/2833 (20130101) C07K 2317/53 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148873 | Govindan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IMMUNOMEDICS, INC. (Foster City, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Serengulam V. Govindan (Springfield, New Jersey); David M. Goldenberg (Delray beach, Florida) |
| ABSTRACT | The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an anti-Trop-2 antibody or antigen-binding antibody fragment. In preferred embodiments, the antibody may be an hRS7 antibody. The methods and compostions are of use to treat Trop-2 expressing cancers in human patients, preferably in patients who are resistant to or relapsed from at least one prior anti-cancer therapy, more preferably in patients who are resistant to or relapsed from treatment with irinotecan. The immunoconjugate may be administered at a dosage of 3 mg/kg to 18 mg/kg, preferably 8 to 12 mg/kg, more preferably 8 to 10 mg/kg. When administered at specified dosages and schedules, the immunoconjugate can reduce solid tumors in size and reduce or eliminate metastases. Preferred tumors to treat with the subject immunoconjugates include triple-negative breast cancer, HER+, ER+, progesterone+ breast cancer, metastatic non-small-cell lung cancer, a metastatic small-cell lung cancer and metastatic pancreatic cancer. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/473123 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/454 (20130101) A61K 31/513 (20130101) A61K 31/675 (20130101) A61K 31/713 (20130101) A61K 31/4184 (20130101) A61K 31/4375 (20130101) A61K 31/4745 (20130101) A61K 31/7088 (20130101) A61K 33/243 (20190101) A61K 45/06 (20130101) Original (OR) Class A61K 47/6803 (20170801) A61K 47/6849 (20170801) A61K 47/6851 (20170801) A61K 47/6853 (20170801) Peptides C07K 16/30 (20130101) C07K 16/2803 (20130101) C07K 16/2833 (20130101) C07K 16/2887 (20130101) C07K 16/3007 (20130101) C07K 16/3046 (20130101) C07K 2317/24 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) C07K 2317/565 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148878 | ZHANG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong ZHANG (Los Angeles, California) |
| ABSTRACT | A poly ADP-ribose polymerase (PARP)-effector molecule conjugate comprising an automodified PARP having a plurality of poly ADP-ribose (ADPr) polymers on a surface of the automodified PARP, wherein the poly ADPr polymers comprise two or more 3′-azido NAD+ moieties, and the effector molecule is conjugated to at least one of the 3′-azido NAD+ moieties of the poly ADPr polymers while at least one of the 3′-azido NAD+ moieties remain unconjugated. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/493223 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/64 (20170801) A61K 47/549 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148881 | XU |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PEISHENG XU (COLUMBIA, South Carolina) |
| ABSTRACT | A carrier-free nanoparticle based on the self-assembly of curcumin-erlotinib conjugate (EPC) that exhibits stronger cell killing, better anti-migration effects, and anti-invasion effects for pancreatic cancer cells than the combination of free curcumin and erlotinib. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/409042 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 47/55 (20170801) Original (OR) Class A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148885 | Spiegel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); Rebecca Howell (New Haven, Connecticut); David McDonald (New Haven, Connecticut) |
| ABSTRACT | The present disclosure provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of an extracellular or cell surface protein. In certain embodiments, the extracellular protein mediates a disease and/or disorder in a subject, and treatment or management of the disease and/or disorder requires degradation, removal, and/or reduction in concentration of the protein in the subject. In some embodiments, the disease and/or disorder is a neurological disease and/or disorder. Thus, in certain embodiments, administration of a compound of the disclosure to the subject removes or reduces the amount of the extracellular or cell surface protein in the brain, thus treating, ameliorating, or preventing the disease and/or disorder. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/547289 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/55 (20170801) A61K 47/60 (20170801) A61K 47/64 (20170801) Original (OR) Class A61K 47/545 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148889 | Myers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Andrew G. Myers (Cambridge, Massachusetts); Ethan L. Magno (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are antibody drug conjugates of Formula (I): G-R7(I) and pharmaceutically acceptable salts thereof, wherein G is a molecular payload; and R7 is -L-A-B, wherein L is a linking group, A is a conjugating group, and B is an antibody or antibody fragment. Also provided are methods of preparing the antibody-drug conjugates, pharmaceutically acceptable compositions thereof, and methods of their use and treatment. Further provided are precursors to the antibody drug conjugates (e.g., compounds of Formula (III), novel trioxacarcins without an antibody conjugated thereto), pharmaceutical compositions thereof, and methods of their use and treatment. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 18/009265 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6809 (20170801) Original (OR) Class A61K 47/6889 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148900 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmon, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guizhi ZHU (Glen Allen, Virginia); Yu ZHANG (Richmond, Virginia) |
| ABSTRACT | Provided herein are pH-responsive nanovaccines (NVs) that stimulate the immune system. The NVs comprise nano- or micro-particles to which CDN-modified i-motif DNA is attached. When endocytosed within a subject to whom they are delivered, the change in pH to an acidic environment cause the CDNs to be released from the NVs. The CDNs are STING (stimulator of interferon genes) agonists and after their release, they bind to and activate STING, a critical step in stimulating the immune system. The NVs are used e.g. for cancer immunotherapy, to treat viral infections and/or as vaccine adjuvants. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 18/281108 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/549 (20170801) A61K 47/6937 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148904 | Duan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongsheng Duan (Columbia, Missouri); Yi Lai (Columbia, Missouri); Junling Zhao (Columbia, Missouri); Yongping Yue (Columbia, Missouri) |
| ABSTRACT | Synthetic nucleic acids encoding mini and microdystrophin genes comprising the membrane binding motifs or domains of the R10-R11-R12 region are provided. Also provided are vectors, host cells, and related methods of using the same to treat a subject suffering from Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) or X-linked dilated cardiomyopathy (XLDC), or for ameliorating one or more adverse effects of DMD, BMD, or XLDC. Also provided are a fusion protein comprising a nNOS binding domain of dystrophin R16-R17 that is operably linked to a syntrophin PDZ domain and synthetic nucleic acids comprising the same that can be used to treat subjects with diseases characterized by loss of sarcolemmal neuronal nitric oxide synthase (nNOS) activity. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511568 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) A61K 38/00 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) Peptides C07K 14/4716 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) C12N 15/62 (20130101) C12N 15/85 (20130101) C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240148911 — FLUORESCENT COMPOUND COMPRISING A FLUOROPHORE CONJUGATED TO A pH-TRIGGERED POLYPEPTIDE
| US 20240148911 | RESHETNYAK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES (Kingston, Rhode Island); YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yana K. RESHETNYAK (Saunderstown, Rhode Island); Oleg A. ANDREEV (Saunderstown, Rhode Island); Donald M. ENGELMAN (New Haven, Connecticut) |
| ABSTRACT | The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided. |
| FILED | Monday, July 10, 2023 |
| APPL NO | 18/349851 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/0082 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/04 (20130101) A61K 49/0034 (20130101) A61K 49/0056 (20130101) Original (OR) Class A61K 49/221 (20130101) A61K 49/227 (20130101) Peptides C07K 14/001 (20130101) C07K 19/00 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 69/107 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1466 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148915 | Hooker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Hooker (Belmont, Massachusetts); Changning Wang (Melrose, Massachusetts); Martin Georg Strebl-Bantillo (Somerville, Massachusetts); Johanna Kaarina Rokka (Boston, Massachusetts) |
| ABSTRACT | Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390906 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/04 (20130101) Original (OR) Class General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 259/10 (20130101) C07C 2602/42 (20170501) C07C 2603/74 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149077 | Humayun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Mark S. Humayun (Glendale, California); Qifa Zhou (Los Angeles, California); Xuejun Qian (Los Angeles, California); Biju Thomas (Los Angeles, California); Gengxi Lu (Los Angeles, California) |
| ABSTRACT | Retinal disease is responsible for many instances of vision impairment. Often, individuals with vision impaired due to retinal disease continue to have functioning retinal neurons. Thus, systems, methods, and devices to stimulate retinal neurons may restore sight for vision-impaired individuals. Systems, methods, and devices provided herein direct ultrasound energy into retinal neurons and modulate phase and amplitude of ultrasound energy in time and space domains in order to variously stimulate various retinal neurons, generating neural responses consistent with visual reproduction of intended images. |
| FILED | Thursday, January 20, 2022 |
| APPL NO | 18/272774 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/0026 (20130101) A61N 2007/0056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149188 | GODFREY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Glenn GODFREY (Carmel, Indiana); Meghav VERMA (Gaithersburg, Maryland); Vishakha GOYAL (Gaithersburg, Maryland); Pranav BENDE (University Park, Maryland); Linus Eric WALLGREN (Chevy Chase, Maryland); James Cullen KLEIN (Rockville, Maryland) |
| ABSTRACT | Methods and systems for solid phase extraction procedures are provided. Methods and systems of the present disclosure provide for improved accuracy, automation, and ease of use of various solid phase extraction procedures and other processes to be performed in a laboratory setting. Systems and methods for fluid flow regulation and detection are disclosed. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 18/550239 |
| CURRENT CPC | Separation B01D 15/24 (20130101) Original (OR) Class Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 23/292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149245 | Turker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melik Z. Turker (Princeton, New Jersey); Thomas C. Gardinier, II (Raritan, New Jersey); Joshua A. Hinckley (Framingham, Massachusetts); Ulrich B. Wiesner (Ithaca, New York) |
| ABSTRACT | The present disclosure provides methods of analyzing and/or purifying inorganic nanoparticles that may be functionalized with one or more dye group. Analyzing and/or purifying the inorganic nanoparticles includes utilizing liquid chromatography, such as, for example, high performance liquid chromatography (HPLC). Methods of the present disclosure may be used to determine the location of one or more dye groups on and/or in the inorganic nanoparticles. The present disclosure also provides methods of making inorganic nanoparticles and compositions of inorganic nanoparticles. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/773267 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0093 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/08 (20130101) B01J 20/16 (20130101) B01J 20/22 (20130101) B01J 20/103 (20130101) B01J 20/262 (20130101) B01J 20/286 (20130101) Original (OR) Class B01J 20/3085 (20130101) B01J 20/3204 (20130101) B01J 20/3217 (20130101) B01J 20/3272 (20130101) B01J 20/3293 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/8624 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149268 | Beebe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Salus Discovery, LLC (Madison, Wisconsin); Flambeau Diagnostics, LLC (Monona, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Beebe (Monona, Wisconsin); Patrick McMinn (Madison, Wisconsin); Brianna Mullins (Deforest, Wisconsin); Jay Warrick (Madison, Wisconsin) |
| ABSTRACT | Devices for isolating, collecting and/or transferring target molecules to an assay area, comprising an enclosure having a top section adapted to receive a sample, a central hollow body section or other area or cavity suitable for receiving a magnet or magnetic field(s) or force(s), at least one aqueous phase or layer and at least one oil/wax or gaseous phase or layer stabilized in proximity to one another within the enclosure with a target-permeable structural material associated with the aqueous phase/layer or the gaseous or oil/wax phase/layer or both, and a lower section containing or adapted to contain one or more reagents for carrying out an assay. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/387625 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) Original (OR) Class B01L 2300/16 (20130101) B01L 2300/023 (20130101) B01L 2300/0829 (20130101) B01L 2400/043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149275 | Hayes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Hayes (Gilbert, Arizona); Claire Crowther (Tempe, Arizona); Paul Jones (Mesa, Arizona) |
| ABSTRACT | The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479220 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 2400/086 (20130101) B01L 2400/0424 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 5/005 (20130101) B03C 5/026 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1023 (20240101) G01N 15/1484 (20130101) G01N 27/447 (20130101) G01N 27/44791 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150286 | Eeda et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venkateswararao Eeda (Oklahoma City, Oklahoma); Weidong Wang (Edmond, Oklahoma); Dan Wu (Moore, Oklahoma) |
| ABSTRACT | Compounds and methods for treating insulin resistance, obesity, Type 2 diabetes, Nonalcoholic fatty liver disease (NAFLD), and peroxisome proliferator-activated receptor gamma (PPARy) serine 273 phosphorylation in subjects in need of such therapy. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/383708 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/04 (20180101) A61P 3/10 (20180101) Heterocyclic Compounds C07D 209/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150290 | Jacobson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kenneth A. Jacobson (Silver Spring, Maryland); Young-Hwan Jung (Rockville, Maryland); Zhiwei Wen (Rockville, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Kenneth A. Jacobson (Silver Spring, Maryland); Young-Hwan Jung (Rockville, Maryland); Zhiwei Wen (Rockville, Maryland) |
| ABSTRACT | Disclosed are compounds for treating or preventing a disease or disorder responsive to antagonism of a P2Y14R receptor agonist in a mammal in need thereof, for example, compounds of formulas (I) and (II), wherein R1-R8, X, Y, Z, X′, Y′, Z′, and A are as defined herein, that are useful in treating an inflammatory such as asthma, cystic fibrosis, and sterile inflammation of the kidney. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 18/272435 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) Heterocyclic Compounds C07D 205/04 (20130101) C07D 205/12 (20130101) C07D 207/08 (20130101) C07D 209/52 (20130101) C07D 211/34 (20130101) Original (OR) Class C07D 211/62 (20130101) C07D 221/04 (20130101) C07D 221/22 (20130101) C07D 223/04 (20130101) C07D 225/02 (20130101) C07D 249/06 (20130101) C07D 261/08 (20130101) C07D 401/10 (20130101) C07D 401/14 (20130101) C07D 403/10 (20130101) C07D 413/10 (20130101) C07D 451/06 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6518 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150297 | Petrukhin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); Albany College of Pharmacy and Health Sciences in the City of Albany (Albany, New York); PETRUKIN, Konstantin (Windsor, New York); RACZ, Boglarka (Brooklyn, New York); VARADI, Andras (Brooklyn, New York); CIOFFI, Christopher, L. (Albany, New York); MUTHURAMAN, Parthasarathy (Albany, New York); RAJA, Arun (Albany, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York); Albany College of Pharmacy and Health Sciences in the City of Albany (Albany, New York) |
| INVENTOR(S) | Konstantin Petrukhin (New Windsor, New York); Boglarka Racz (Brooklyn, New York); Andras Varadi (Brooklyn, New York); Christopher : Cioffi (Albany, New York); Parthasarathy Muthuraman (Albany, New York); Arun Raja (Albany, New York) |
| ABSTRACT | The present invention provides a compound having the structure: wherein X1 is N or CR5, wherein R5 is H, OH, halogen or alkyl; X2, X3 and X4 are each independently NH, N, S, O or CR6, wherein each R6 is independently H, OH, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, haloalkyl, —O—(alkyl), —S—(alkyl), —NH2, —NH—(alkyl), —N(alkyl)2 or —CO2H; R1, R2, R3 and R4 are each independently —H, —F, —Cl, —Br, —I, —NO2, —CN, —CF3, —CF2H, —OCF3, -(alkyl), -(haloalkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(cycloalkyl), -(cycloalkylalkyl), -(heteroalkyl), heterocycle, heterocycloalkyl, -(alkylheteroalkyl), -(alkylaryl), —OH, —OAc, —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), (heteroaryl), —SH, —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), —S-(heteroaryl), —NH2, —NH-(alkyl), —NH-(alkenyl), —NH-(alkynyl), —NH-(aryl), —NH-(heteroaryl), —C(O)R7, —S(O)R7, —SO2R7, —NHSO2R7, —OC(O)R7, —SC(O)R7, —NHC(O)R7 or —NHC(S)R7, wherein R7 is, H, —(alkyl), —OH, —O(alkyl), —NH2, —NH(alkyl) or —N(alkyl)2; B is absent or present, and when present is wherein R8 is H, OH, halogen, alkyl, cycloalkyl, cycloalkylalkyl, —O-(alkyl), —S-(alkyl), —NH2, —NH-(alkyl), —N(alkyl)2 or —CO2H; and C is H, substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, aryl, heteroaryl, alkyl, cycloalkyl, cycloalkylalkyl, CO2H, COOR9, OH, OR9, NH2, NHR9, NR9R10, SO2R11, CH2NHR9, CH2NR9R10 or CH2COOR9, wherein R9 and R10 are each independently H, alkyl, cycloalkyl, —C(O)-alkyl, —C(O)-cycloalkyl, —C(O)OH, —C(O)—O-alkyl, —C(O)—O-cycloalkyl, —C(O)NH2, —C(O)NH(alkyl), —C(O)NH(cycloalkyl), —C(O)N(alkyl)2, —CH2NH(alkyl), —CH2COOH, —SO2CH3, —OH, —O(alkyl), —NH2, —NH(alkyl) or —N(alkyl) wherein R11 is alkyl, haloalkyl, cycloalkyl, aryl, heteroaryl, NH2, NH(alkyl), NH(cycloalkyl), NH(heterocycle), NH(aryl), NH(heteroaryl) or NHCOR12, wherein R12 is alkyl, haloalkyl, cycloalkyl, heterocycle, aryl or heteroaryl, or a pharmaceutically acceptable salt thereof. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 18/264994 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Heterocyclic Compounds C07D 231/38 (20130101) Original (OR) Class C07D 261/14 (20130101) C07D 275/03 (20130101) C07D 403/12 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150298 | TENG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Blacksmith Medicines, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min TENG (San Diego, California); Baskar NAMMALWAR (San Diego, California); Xiaoming LI (San Diego, California); Christian PEREZ (San Diego, California); David T. PUERTA (San Diego, California) |
| ABSTRACT | Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 18/276588 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 233/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150311 | Hamrick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Hamrick (Evans, Georgia); Carlos Isales (Augusta, Georgia); Iryna Lebedyeva (Augusta, Georgia) |
| ABSTRACT | Provided herein are compounds that inhibit IDO1 and methods of use thereof. Also provided are pharmaceutical compositions and medicaments that include the compounds described herein as well as methods of treating sarcopenia or age-related muscle loss. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/542302 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 69/66 (20130101) Heterocyclic Compounds C07D 311/06 (20130101) C07D 317/60 (20130101) Original (OR) Class C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150315 | MacKerell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander D. MacKerell (Baltimore, Maryland); Deepak Deshpande (North Wales, Pennsylvania); Christopffer Lind (Headington, United Kingdom); Sushrut D. Shah (Bensalem, Pennsylvania) |
| ABSTRACT | The disclosure relates to allosteric modulators of β2-adrenoceptor, pharmaceutical compositions thereof, and use thereof for the treatment of disease. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482497 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) Heterocyclic Compounds C07D 401/06 (20130101) Original (OR) Class C07D 403/04 (20130101) C07D 403/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150323 | Pomper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin G. Pomper (Baltimore, Maryland); Ronnie C. Mease (Fairfax, Virginia); Ying Chen (Timonium, Maryland); Sangeeta Ray (Ellicott City, Maryland) |
| ABSTRACT | Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/479900 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 49/0032 (20130101) A61K 49/0052 (20130101) Heterocyclic Compounds C07D 403/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150338 | BANNISTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); VOVA IDA THERAPEUTICS, INC. (Jupiter, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. BANNISTER (Palm Beach Gardens, Florida); Corinne LASMEZAS (Palm Beach Gardens, Florida); Minghai ZHOU (Jupiter, Florida); Sultan ULLAH (Jupiter, Florida) |
| ABSTRACT | Provided are, inter alia, compounds having a structure of Formulae (X) to (XVII), or a subordinate structure thereof, composition including the same and methods of use. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 18/261682 |
| CURRENT CPC | Heterocyclic Compounds C07D 277/42 (20130101) C07D 417/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150353 | MacMillan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. MacMillan (Princeton, New Jersey); Olivia L. Garry (Princeton, New Jersey); Yufan Liang (Cambridge, Massachusetts); Michael Heilmann (Princeton, New Jersey) |
| ABSTRACT | Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/547462 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 51/363 (20130101) C07C 67/08 (20130101) C07C 69/76 (20130101) C07C 69/753 (20130101) C07C 69/757 (20130101) C07C 2602/38 (20170501) Heterocyclic Compounds C07D 209/08 (20130101) C07D 209/48 (20130101) C07D 209/88 (20130101) C07D 213/26 (20130101) C07D 213/55 (20130101) C07D 231/16 (20130101) C07D 231/56 (20130101) C07D 403/08 (20130101) C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150372 | Sames et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); High Point University (High Point, North Carolina) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York); High Point University (High Point, North Carolina) |
| INVENTOR(S) | Dalibor Sames (New York, New York); Vaclav Havel (Opava 9, Czech Republic); Scott Hemby (High Point, North Carolina) |
| ABSTRACT | The present invention provides a method of treating a subject afflicted with a substance use disorder (SUD) comprising administering to the subject an effective amount of a compound having the structure: wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y2 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y4 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y6 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); α and β are each present or absent and when present each is a bond, wherein either α or β is present, and when α is present, then X1 is C and X2 is S or O, or when β is present, then X1 is N and X2 is N; and R1, R2, R3 and R4 are each independently —H, -(alkyl), -(alkenyl), -(alkynyl), -(haloalkyl), -(cycloalkyl), -(aryl), -(heteroaryl), -(heteroalkyl), -(hydroxyalkyl), -(alkyl)-(aryl), -(alkyl)- (heteroaryl), -(alkyl)-(cycloalkyl), -(alkyl)-OH, -(alkyl)-O-(alkyl), —OH, —NH2, —OAc, —CO2H, —CN, OCF3, halogen, —CO2—(C2-C12 alkyl), C(O)—NH2, —C(O)—NH-(alkyl), C(O)—NH-(aryl), —O-alkyl, —O-alkenyl, —O-alkynyl, —O-aryl, —O-(heteroaryl), —NH-alkyl, —NH-alkenyl, —NH-alkynyl, —NH-aryl, —NH-(heteroaryl), —O—C(O) (alkyl), or —C(O)—N(alkyl)2, or a pharmaceutically acceptable salt or ester thereof, so as to thereby treat the subject afflicted with the substance use disorder (SUD). |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 18/546772 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) A61P 29/00 (20180101) Heterocyclic Compounds C07D 471/22 (20130101) C07D 491/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150382 | Jeon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junha Jeon (Southlake, Texas); Hiep Hoang Nguyen (Arlington, Texas) |
| ABSTRACT | The present disclosure provides compounds that may be used as ligands in metal-catalyzed reactions, in particular 3,3′-bisilyl biaryl phosphoramidite compounds and processes for preparing the same. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530775 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/081 (20130101) C07F 7/0812 (20130101) C07F 7/0829 (20130101) C07F 9/65744 (20130101) C07F 9/65842 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150396 | Meek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas); The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. Meek (College Station, Texas); Linfeng Li (College Station, Texas); Chien-Te Kent Tseng (Galveston, Texas); Aleksandra Drelich (Galveston, Texas) |
| ABSTRACT | Provided herein are pharmaceutical compositions including compounds having Formula (I) in an effective amount to inhibit cysteine protease as well as methods of using thereof. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/280400 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 33/02 (20180101) Peptides C07K 5/06139 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150397 | Teesalu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tambet Teesalu (La Jolla, California); Erkki Ruoslahti (La Jolla, California); Kazuki Sugahara (La Jolla, California); Shweta Sharma (La Jolla, California) |
| ABSTRACT | Disclosed are peptides and peptidomimetics that in some embodiments include the amino acid sequence KRGARST or (SEQ ID NO: 1), AKRGARSTA or (SEQ ID NO: 2), or CKRGARSTC (SEQ ID NO: 3). Also disclosed are conjugates and compositions that include the peptides and/or peptidomimetics, methods for directing a moiety to tumor lymphatic vasculature, methods for imaging tumor lymphatic vasculature, methods for reducing or inhibiting tumor metastasis, methods for reducing the number of tumor lymphatic vessels, methods for treating cancer, methods for treating a disease or disorder associated with a gC1q/p32 receptor biological activity, methods for detecting the presence of a gC1q/p32 receptor, methods for detecting interactions between gC1q/p32 receptors and the presently disclosed conjugates and compositions, methods for delivering the presently disclosed conjugates and compositions to gC1q/p32 receptors, methods for assessing gC1q/p32 receptor levels in cells, methods for identifying subjects having diseases associated with gC1q/p32 receptor biological activities, and methods for screening for compounds that interact with gC1q/p32 receptors. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 18/050964 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/64 (20170801) A61K 47/6455 (20170801) A61K 47/6929 (20170801) A61K 49/1866 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6872 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150404 | PEI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dehua PEI (Columbus, Ohio) |
| ABSTRACT | Anticachexin C1 inhibits the TNFα-TNFα receptor interaction. In this work, analogs of anticachexin C1 are disclosed. The resulting bicyclic peptides inhibit TNFα TNFα-induced cell death, NF-κB activation, and c-Jun N-terminal kinase (JNK) signaling in cultured mammalian cells. Methods of using the bicyclic peptide anticachexin C1 analogs to treat cancer, inflammatory disorders and immune disorders are also described. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541815 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 7/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150438 | WESTENDORF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn WESTENDORF (Vancouver, Canada); Stefanie ZENTELIS (Vancouver, Canada); Krithika MUTHURAMAN (Toronto, Canada); Kevin JEPSON (Vancouver, Canada); Ester FALCONER (North Vancouver, Canada); John MASCOLA (Bethesda, Maryland); Barney GRAHAM (Bethesda, Maryland); Kizzmekia CORBETT (Bethesda, Maryland); Julie LEDGERWOOD (Bethesda, Maryland); Lingshu WANG (Bethesda, Maryland); Olubukola ABIONA (Bethesda, Maryland); Wei SHI (Bethesda, Maryland); Wing-pui KONG (Bethesda, Maryland); Yi ZHANG (Bethesda, Maryland); Bryan Edward JONES (San Diego, California); Denisa FOSTER (San Diego, California); Julian DAVIES (La Jolla, California); Qing CHAI (San Diego, California); Christopher Carl FRYE (Bargersville, Indiana); Ganapathy GOPALRATHNAM (Fishers, Indiana); Jörg HENDLE (San Diego, California); John Michael SAUDER (Carlsbad, California); Jeffrey Streetman BOYLES (Indianapolis, Indiana); Anna PUSTILNIK (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/194105 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 47/02 (20130101) A61K 47/26 (20130101) A61K 47/68 (20170801) A61K 47/183 (20130101) A61K 47/6801 (20170801) A61K 47/6803 (20170801) A61K 47/6841 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150439 | Nussenzweig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Michel Nussenzweig (New York, New York); Davide F. Robbiani (New York, New York) |
| ABSTRACT | This disclosure provides novel broadly neutralizing anti-SARS-CoV-2 antibodies or antigen-binding fragments thereof. The disclosed anti-SARS-CoV-2 antibodies constitute a novel therapeutic strategy in protection from SARS-CoV-2 infections. |
| FILED | Monday, April 24, 2023 |
| APPL NO | 18/305937 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/33 (20130101) C07K 2317/35 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150443 | POROTTO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matteo POROTTO (New York, New York); Anne MOSCONA (New York, New York); Branka HORVAT (Lyon, France); Cyrille MATHIEU (Lyon, France) |
| ABSTRACT | Compositions, and methods of preventing Measles and other viral infections using the compositions, related to single-chain variable fragment- (scFv-) based antivirals that bind to the measles virus (eV) F peptide and block F-mediated membrane fusion, thereby preventing infection. The scFv may interact synergistically with MeV fusion inhibitory peptides, such as HRC4. The scFv may be administered to the patient by airway, such as intranasally, and may be co-administered with one or more MeV fusion inhibitory peptides, such as HRC4. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491733 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1027 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150445 | HAYNES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barton F. HAYNES (Durham, North Carolina); Kevin J. WIEHE (Durham, North Carolina); Mattia BONSIGNORI (Durham, North Carolina) |
| ABSTRACT | The invention is directed to methods to identify improbable mutations in the heavy or light chain variable domain of an antibody, methods to identify antigens which bind to antibodies comprising such improbable mutations, and methods of using such antigens to induce immune responses. |
| FILED | Wednesday, July 05, 2023 |
| APPL NO | 18/347145 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Peptides C07K 16/1063 (20130101) Original (OR) Class C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16034 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150453 | Shalek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Seattle Children's Hospital DBA Seattle Children's Research Institute (Seattle, Washington); The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander K. Shalek (Cambridge, Massachusetts); Leslie Kean (Seattle, Washington); Jose Ordovas-Montanes (Boston, Massachusetts); Hengqi Zheng (Seattle, Washington); Benjamin Doran (Cambridge, Massachusetts); Kyle Kimler (Boston, Massachusetts) |
| ABSTRACT | The subject matter disclosed herein is generally directed to stratifying and treating inflammatory diseases. In particular, the present invention provides for detecting treatment naive cell states that predict the response of a subject having inflammatory bowel disease to anti-TNF-blockade. The cells are T cells, NK cells, innate lymphoid cells, myeloid and/or epithelial cell subsets defined by their gene expression as determined by single cell RNA sequencing. Alternatively, the responders are identified by gene expression in a sample. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 18/280547 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 29/00 (20180101) Peptides C07K 16/241 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 2800/52 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150494 | Bournazos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stylianos Bournazos (New York, New York); Jeffrey V. Ravetch (New York, New York); Aaron Gupta (New York, New York); Kevin Kao (New York, New York) |
| ABSTRACT | This disclosure is based, at least in part, on an unexpected discovery that the novel nanobodies and variants thereof are able to specifically bind afucosylated or sialylated IgG Fc glycoforms. Glycosylation of the IgG Fc domain is a major determinant of the strength and specificity of antibody effector functions, modulating the binding interactions of the Fc with the diverse family of Fcγ receptors. These Fc glycan modifications, such as removal of the core fucose residue, are newfound clinical markers for predicting severity of diseases, such as diseases caused by dengue virus (DENV) or SARS-CoV-2. However, it remains challenging to accurately distinguish specific IgG glycoforms without costly and time-intensive methods. The novel glycol-specific nanobodies and variants thereof, as disclosed herein, can be used as rapid clinical diagnostics or prognostics to risk stratify patients with viral and inflammatory diseases. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 18/550059 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) A61K 38/4873 (20130101) A61K 39/39566 (20130101) A61K 45/06 (20130101) A61K 47/6873 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/4216 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/40 (20130101) C07K 2317/76 (20130101) C07K 2317/569 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) C12N 9/2402 (20130101) Enzymes C12Y 302/01096 (20130101) C12Y 304/2201 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2333/185 (20130101) G01N 2440/38 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150709 | Zeltner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nadja Zeltner (Athens, Georgia); Hsueh Fu Wu (Athens, Georgia) |
| ABSTRACT | Parasympathetic neurons (parasymN) are important for unconscious body responses, including rest-and-digest and calming the body. Disclosed herein is a chemically defined differentiation protocol that generates parasympathetic neurons from stem cells. The protocol yields high efficiency and purity cultures that are electrically active and respond to specific stimuli. Their molecular characteristics and maturation stage are described and evidence for their use as a model for studying parasymN function and dysfunction. Cell populations and compositions formed from the resulting cells, as well as methods of their use for disease treatment, drug screening, and modeling of human disorders affecting parasymN are also provided. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/503100 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) Original (OR) Class C12N 2500/32 (20130101) C12N 2501/13 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2506/00 (20130101) C12N 2513/00 (20130101) C12N 2533/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150710 | Ullian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik M. Ullian (San Francisco, California); Mark Koontz (San Francisco, California); Robert Krencik (San Francisco, California) |
| ABSTRACT | Compositions and methods are provided for generation of assembled three-dimensional organoids with defined numbers and ratios of mature neurons and mature glia. Organoids can be assembled from mature neurons and mature glia derived from induced pluripotent stem cells having at least one genetic mutation associated with a neurological disorder, a neurodevelopmental disorder, or a neurodegenerative disease. Such organoids can be used in disease modeling and drug screening. In particular, assembled three-dimensional organoids are provided that model granulin (GRN) loss of function in neurons and astrocytes, which display many of the pathological features of neuronal ceroid lipofusis and frontotemporal dementia. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 18/278719 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 5/0622 (20130101) Original (OR) Class C12N 9/22 (20130101) C12N 2310/20 (20170501) C12N 2501/11 (20130101) C12N 2501/13 (20130101) C12N 2501/40 (20130101) C12N 2501/115 (20130101) C12N 2503/04 (20130101) C12N 2506/08 (20130101) C12N 2513/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150741 | Joung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Benjamin Kleinstiver (Boston, Massachusetts) |
| ABSTRACT | Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507709 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2227/40 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 2319/71 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/63 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2800/22 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150752 | KITTLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Ralf KITTLER (Dallas, Texas); John D. MINNA (Dallas, Texas); Paul M. YENERALL (Dallas, Texas) |
| ABSTRACT | Disclosures herein are directed to methods and compositions for the detection of and screening for mutations that convey phenotypic properties in a protein such as, for example, drug-resistance. Embodiments of the present disclosure include lentiviral-based compositions for transferring a gene encoding a protein of interest into a target cell for screening according to methods disclosed herein. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 18/280803 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/1079 (20130101) Original (OR) Class C12N 15/1086 (20130101) C12N 2740/15022 (20130101) C12N 2740/15043 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150755 | Zheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Salk Institute for Biological Studies (La Jolla, California) |
| ASSIGNEE(S) | Salk Institute for Biological Studies (La Jolla, California) |
| INVENTOR(S) | Ye Zheng (La Jolla, California); Diana Hargreaves (La Jolla, California); Chin-San Loo (La Jolla, California); Jovylyn Gatchalian (La Jolla, California) |
| ABSTRACT | Methods of modulating regulatory T (Treg) suppressor activity are provided. Also provided are methods of treating autoimmune diseases and methods of treating cancer. The methods include increasing or reducing the expression or activity of bromodomain-containing 9 (Brd9), bromodomain-containing 7 (Brd7), and/or polybromo 1 (Pbrm1) in a Treg cell or in a subject. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 18/278824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150759 | Pasca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergiu P. Pasca (Stanford, California); Xiaoyu Chen (Stanford, California); Fikri Birey (Stanford, California) |
| ABSTRACT | The present disclosure provides methods of treating an individual having Timothy syndrome. Aspects of the methods include administering an effective dose of an agent to the individual, wherein the agent modulates the splicing of an 8 A or an 8 exon of CACNA1C. Also provided are compositions that find use in practicing embodiments of the methods. |
| FILED | Friday, October 27, 2023 |
| APPL NO | 18/496554 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/321 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150764 | Basri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Noah Basri (St. Louis, Missouri); Ting Wang (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Noah Basri (St. Louis, Missouri); Ting Wang (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides for splice-switching oligonucleotides (SSOs) targeted to a nucleic acid encoding a transposable element (TE)-driven isoform of LIN28B, such as AluJb-LIN28B. The SSOs may be targeted to an exon-intron or intron-exon junction to inhibit splicing and expression of the TE-driven isoform of LIN28B. Methods of treating cancer, particularly cancers expressing AluJb-LIN28B, comprising administering the SSOs are also provided. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/503495 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150772 | Sullenger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Bruce A. Sullenger (Durham, North Carolina); Michael Goldstein (Durham, North Carolina); Elizabeth D. Pratico (Durham, North Carolina); Michael Kastan (Durham, North Carolina); Bethany Gray (Durham, North Carolina) |
| ABSTRACT | Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided. |
| FILED | Friday, June 02, 2023 |
| APPL NO | 18/205390 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class C12N 2310/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150811 | Abate et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam R. Abate (Daly City, California); John R. Haliburton (San Francisco, California); Freeman Lan (San Francisco, California); Adam R. Sciambi (San Francisco, California) |
| ABSTRACT | Microfluidic methods for barcoding nucleic acid target molecules to be analyzed, e.g., via nucleic acid sequencing techniques, are provided. Also provided are microfluidic, droplet-based methods of preparing nucleic acid barcodes for use in various barcoding applications. The methods described herein facilitate high-throughput sequencing of nucleic acid target molecules as well as single cell and single virus genomic, transcriptomic, and/or proteomic analysis/profiling. Systems and devices for practicing the subject methods are also provided. |
| FILED | Thursday, June 22, 2023 |
| APPL NO | 18/212868 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 25/4338 (20220101) B01F 33/3021 (20220101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 7/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6804 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150830 | Aiden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Erez Lieberman Aiden (Houston, Texas); Galina Aglyamova (Houston, Texas); Ivan Bochkov (Houston, Texas); Olga Dudchenko (Houston, Texas); Saul Godinez (Houston, Texas); Huiya Gu (Houston, Texas); Ragini Mahajan (Houston, Texas); Suhas Rao (Stanford, California); Andreas Gnirke (Cambridge, Massachusetts); Elena Stamenova (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erez Lieberman Aiden (Houston, Texas); Galina Aglyamova (Houston, Texas); Ivan Bochkov (Houston, Texas); Olga Dudchenko (Houston, Texas); Saul Godinez (Houston, Texas); Huiya Gu (Houston, Texas); Ragini Mahajan (Houston, Texas); Suhas Rao (Stanford, California); Andreas Gnirke (Cambridge, Massachusetts); Elena Stamenova (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed are methods for obtaining genome scale and fully phased epigenetic maps in a cell. The method enables maintaining intact chromatin structure and interrogating chromatin structure using chromatin accessibility maps. DNA contacts are used to fully phase the epigenetic and chromatin contact maps. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501637 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2600/16 (20130101) C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150836 | Park et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Jason Y. Park (Dallas, Texas); John David Farrar (Dallas, Texas); David E. Gerber (Dallas, Texas); Farjana Fattah (Carrollton, Texas); Hong Mu-Mosley (Dallas, Texas) |
| ABSTRACT | The present disclosure generally relates to compositions and methods for predicting or diagnosing immune-related adverse events (irAE) before, during, or after immune checkpoint inhibitor (ICI) treatment in a subject with cancer. The method includes assessment of transcripts, autoantibody levels, cytokine levels, and immune cells. The irAE can be ICI-related myositis, ICI-related myocarditis or ICI-related myositis and myocarditis. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504868 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 33/6863 (20130101) G01N 33/56972 (20130101) G01N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150839 | CHAKRABORTY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Goutam CHAKRABORTY (New York, New York); Philip KANTOFF (New York, New York) |
| ABSTRACT | The present disclosure provides methods for determining whether a patient diagnosed with or at risk for metastatic castration-resistant prostate cancer will benefit from or is predicted to be responsive to treatment with a PARP inhibitor. These methods are based on detecting a co-deletion in BRCA2 and RB1 in a biological sample obtained from a prostate cancer patient. Kits for use in practicing the methods are also provided. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/773288 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150841 | Flores et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elsa R. Flores (Tampa, Florida); Marco NAPOLI (Tampa, Florida) |
| ABSTRACT | Disclosed herein are 2 novel long non-coding RNAs (lncRNAs), TROLL-2 and TROLL-3. It is shown herein that lncRNAs TROLL-2 and TROLL-3, as well as their effector WDR26, are suitable targets for cancer therapies and can be used to make prognostic determinations about a cancer and determine if immune checkpoint inhibitors should be used to treat a cancer. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 18/277760 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150843 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xianfeng Chen (Scottsdale, Arizona); Yuan Xiao Zhu (Scottsdale, Arizona); Alexander Keith Stewart (Fountain Hills, Arizona); Lisa M. Rimsza (Scottsdale, Arizona) |
| ABSTRACT | Methods and materials for identifying and treating mammals (e.g., humans) having multiple myeloma (MM) are provided herein. For example, this document provides methods and materials that can be used to identify and treat mammals having advanced stage MM, and/or having MVI that is resistant to treatment with immunomodulatory drugs (IMiDs) and/or proteasome inhibitors (PIs). |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 18/282467 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150847 | Balaj et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonora Balaj (Lincoln, Massachusetts); Bob S. Carter (Belmont, Massachusetts); Syeda Maheen Batool (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods for the detection of EGFRvIII mutation in patient samples, e.g., in tumor tissue, cerebrospinal fluid, and plasma samples, using an optimized ddPCR assay. This methods can be used, e.g., for diagnosis, monitoring tumor progression, and assessing response to therapy. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/503936 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150848 | HEYMACH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | John V. HEYMACH (Houston, Texas); Simon HEEKE (Houston, Texas); Lauren A. Byers (Houston, Texas); Carl M. GAY (Houston, Colombia) |
| ABSTRACT | Aspects of the disclosure are directed to methods and systems for diagnosis, classification, and treatment of small cell lung cancer and high grade neuroendocrine carcinomas. Certain aspects comprise detection and analysis of tumor DNA methylation. Included in the disclosure are methods for identifying a subject as having a particular small cell lung cancer subtype based on DNA N methylation analysis, as well as methods and compositions for treatment of a subject based on subtype classification. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/548865 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151509 | Vakoc et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin J. Vakoc (Arlington, Massachusetts); Norman Lippok (Quincy, Massachusetts) |
| ABSTRACT | A method including: scanning a sample over a period of time using an electro-magnetic radiation source, the period of time including a first time period and a second time period, a sample portion of the electro-magnetic radiation source being directed to the sample in a sample arm of an optical interferometric system, and a reference portion of the electro-magnetic radiation source being directed to a reference arm of the optical interferometric system; applying, using a phase modulator, a phase shift comprising a first phase shift and a second phase shift to at least one of the reference portion or the sample portion of the electro-magnetic radiation source, the first phase shift being applied during the first time period and the second phase shift being applied during the second time period, the second phase shift having a difference of 90 degrees from the first phase shift. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505342 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/0201 (20130101) Original (OR) Class G01B 9/02008 (20130101) G01B 9/02091 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151622 | Deng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheri X. Deng (Ann Arbor, Michigan); Jan P. Stegemann (Ann Arbor, Michigan); Weiping Li (Ann Arbor, Michigan); Eric C. Hobson (Ann Arbor, Michigan) |
| ABSTRACT | A new acoustic technique, tensile acoustic rheometry (TAR) for performing rheology measurement of a soft viscoelastic material sample is provided. In TAR, an excitation acoustic pulse is applied using a focused ultrasound transducer to a sample material to induce oscillatory motion of the sample. To track this induced motion, high repetition frequency ultrasound pulse-echo technique is used using a co-linear, con-focal ultrasound transducer that detects the backscattered echo signal from a surface or an interface of the sample. The detection ultrasound transducer system converts the echo signals to an electrical signal, and a processor determines a displacement of the interface of the sample as a function of time. The processor also determines the spectrogram, or the frequency spectrum of the dynamic surface movement of the sample material as a function of the time. Viscoelastic properties of the material are then determined from the displacement and the spectrogram measurements. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/386813 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/00 (20130101) Original (OR) Class G01N 2011/0073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151681 | Yan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri); BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zheng Yan (Columbia, Missouri); Yadong Xu (Columbia, Missouri); Jingwei Xie (Omaha, Nebraska) |
| ABSTRACT | Systems, methods, and devices for providing a phase-separated porous nanocomposite including a porous polymer substrate with a plurality of pores and conductive silver nanowire disposed therein. The pores within the nanocomposite permit stretching and strain loading condition without a substantial impact on electrical properties such as electrical resistance. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/386798 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3278 (20130101) Original (OR) Class Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/16 (20130101) H01B 3/302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151719 | COX et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COBIO DIAGNOSTICS INC. (Golden, Colombia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher R. COX (Golden, Colorado); Andrew J. LOGAN (Denver, Colorado) |
| ABSTRACT | A method and kit for for determining of an effective concentration of an antimicrobial agent for inhibiting bacterial growth are provided. The method and kit involve the use of a first and second multiwell receptacle. A fluid sample containing or suspected to contain one or more microbial organisms is dispensed into the wells of the first multiwell receptacle containing a range of dilutions of an antimicrobial agent, growth medium and a bacteriophage to form assay mixtures in the wells. The assay mixtures are then transferred to the corresponding wells of the second multiwell receptacle for detection. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 18/280907 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/56916 (20130101) Original (OR) Class G01N 33/56938 (20130101) G01N 2333/22 (20130101) G01N 2333/26 (20130101) G01N 2333/31 (20130101) G01N 2333/265 (20130101) G01N 2333/315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151735 | BERETTA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laura BERETTA (Bellaire, Texas) |
| ABSTRACT | A method of detecting hepatocellular carcinoma (HCC) biomarkers in a sample from a human subject by detecting hepatocellular carcinoma biomarkers in the sample. The HCC biomarkers can include Tetracosanoic Acid, Heptadecanoic Acid, Eicosapentaenoic Acid, or Docosapentaenoic Acid. Optionally, the HCC biomarkers can further include osteopontin (OPN) and/or alpha-fetoprotein (AFP). The sample is a sample of a bodily fluid obtained from a human subject. The subject can be a healthy patient, a patient suspected of having a liver disorder, a patient previously diagnosed with liver cirrhosis, or a patient previously diagnosed with liver fibrosis. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 18/548762 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/72 (20130101) G01N 33/92 (20130101) Original (OR) Class G01N 2405/00 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153031 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haoyin Zhou (Boston, Massachusetts); Jayender Jagadeesan (Boston, Massachusetts) |
| ABSTRACT | A method for nonrigid mosaicking of images, including: obtaining, using a processor, a plurality of images including a first image and a second image of a sample, the first image and the second image containing information from partially overlapping portions of the sample; identifying, using the processor, at least one feature match between the first image and the second image; estimating, using the processor, a deformation between the first image and the second image based on identifying the at least one feature match; and combining, using the processor, the first image and the second image based on estimating the deformation between the first image and the second image. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 18/281050 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00009 (20130101) A61B 1/3132 (20130101) Image Data Processing or Generation, in General G06T 3/18 (20240101) G06T 3/4038 (20130101) Original (OR) Class G06T 7/33 (20170101) G06T 7/248 (20170101) G06T 2200/32 (20130101) G06T 2207/10021 (20130101) G06T 2207/10068 (20130101) G06T 2207/20072 (20130101) G06T 2207/20221 (20130101) G06T 2207/30004 (20130101) G06T 2207/30244 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153229 | BUCKLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); Mark A. BUCKLER (Wenham, Massachusetts); Vladimir VALTCHINOV (Boston, Massachusetts); David S. PAIK (Moon Bay, California) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/309903 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) Original (OR) Class G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240148248 | SCHERER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Axel SCHERER (Barnard, Vermont); Peter A PETILLO (Lawrence, Kansas); Samson CHEN (Pasadena, California); Azita EMAMI (Pasadena, California) |
| ABSTRACT | A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals. |
| FILED | Wednesday, April 26, 2023 |
| APPL NO | 18/307361 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 1/031 (20130101) A01K 11/006 (20130101) A01K 29/00 (20130101) Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/002 (20130101) Original (OR) Class A61B 5/1113 (20130101) Transmission H04B 5/24 (20240101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148250 | Maharbiz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michel M. Maharbiz (El Cerrito, California); Jose M. Carmena (Berkeley, California); Mekhail Anwar (San Francisco, California); Burak A. Ozilgen (Berkeley, California); Dongjin Seo (Albany, California); Federica Fava (Berkeley, California) |
| ABSTRACT | Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure. |
| FILED | Wednesday, August 09, 2023 |
| APPL NO | 18/447228 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0031 (20130101) Original (OR) Class A61B 5/076 (20130101) A61B 5/279 (20210101) A61B 5/686 (20130101) A61B 6/4258 (20130101) A61B 8/48 (20130101) A61B 8/085 (20130101) A61B 8/0808 (20130101) A61B 8/0875 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 39/0208 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3605 (20130101) A61N 1/3787 (20130101) A61N 1/37205 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148654 | CARSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Southwest Research Institute (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth H. CARSON (San Antonio, Texas); Spring M. CABINESS (Mico, Texas); Amy M. DE LOS SANTOS (San Antonio, Texas); Karl KLOSE (San Antonio, Texas) |
| ABSTRACT | A lyophilized stabilized formulation containing a live attenuated vaccine strain against tularemia. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/503901 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) Original (OR) Class A61K 39/0208 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148692 | ORONSKY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EpicentRx, Inc. (La Jolla, California) |
| ASSIGNEE(S) | EpicentRx, Inc. (La Jolla, California) |
| INVENTOR(S) | Bryan T. ORONSKY (La Jolla, California); Tony R. REID (La Jolla, California); Arnold ORONSKY (La Jolla, California) |
| ABSTRACT | Provided herein are therapeutic methods, kits, and pharmaceutical compositions for protecting a subject from radiation using a therapeutic agent selected from the group consisting of RRx-OOI and a pharmaceutically acceptable salt thereof. One exemplary therapeutic method involves administering RRx-OOI to the subject prior to the subject being exposed to the radiation, in order to protect the subject against radiation, such as ionizing radiation containing α-rays, β-rays, γ-rays, neutron radiation, or a combination thereof. |
| FILED | Tuesday, June 20, 2023 |
| APPL NO | 18/211792 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/397 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148855 | ZHUANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NE1 Inc. (New York, New York); United States Department of Health and Human Services and the National Institute of Health (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhengping ZHUANG (Bethesda, Maryland); Herui WANG (Mclean, Virginia); Juan YE (Bethesda, Maryland); Bin LU (Falls Church, Virginia) |
| ABSTRACT | The present disclosure generally relates to a personalized cancer vaccine having attenuated cancer cells transfected with at least one expression construct. The expression construct is capable of secretory expression of an antigenic polypeptide that could be derived from a protein from a virus. The personalized tumor vaccine, when administered to a subject in need thereof, is effective to activate an immune response. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 18/550895 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 39/215 (20130101) A61K 39/245 (20130101) A61K 45/06 (20130101) A61K 2039/53 (20130101) A61K 2039/54 (20130101) A61K 2039/505 (20130101) A61K 2039/585 (20130101) A61K 2039/5152 (20130101) A61K 2039/5156 (20130101) A61K 2039/55555 (20130101) A61K 2039/55583 (20130101) Peptides C07K 16/2878 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/16034 (20130101) C12N 2760/16134 (20130101) C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148877 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Peter H. Winegar (Evanston, Illinois); Charles A. Figg (Evanston, Illinois) |
| ABSTRACT | Methods for forming a sequence encoded oligomer includes oligomerizing first and second antibody-oligonucleotide conjugates through hybridization using at least one template oligo nucleotide. The first antibody-oligonucleotide conjugate comprises an oligonucleotide strand comprising a first sequence and a second sequence joined by an alkyne. The second antibody-oligonucleotide conjugate comprises an oligonucleotide strand comprising a third sequence and a fourth sequence joined by an alkyne. The at least one template oligonucleotide strand comprises at least two template sequences, one of the t two template sequences being complementary to one of the first and second sequences of the first antibody-oligonucleotide conjugate and the other being complementary to one of the third and fourth sequences of the second antibody-oligonucleotide conjugate, such that the at least one template oligonucleotide strand hybridizes to a portion of the oligonucleotide strand of the first-antibody-oligonucleotide conjugate and to a portion of the oligonucleotide strand of the second-antibody. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 18/283241 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/549 (20170801) Original (OR) Class Peptides C07K 16/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149995 | Rufo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boston Engineering Corporation (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Rufo (Hanover, Massachusetts); Michael Conry (Beverly, Massachusetts); Todd Scrimgeour (North Hero, Vermont) |
| ABSTRACT | A technique for carrying a payload by a UUV includes providing a structure that extends around an outer surface of the UUV along a length of the UUV. The structure has an outer membrane that forms a streamlined shape around the UUV and contains the payload. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501545 |
| CURRENT CPC | Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/001 (20130101) Original (OR) Class B63G 2008/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150005 | Gross et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SciMax Technologies, LLC (Long Beach, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Max Gross (Long Beach, New York); Joseph Bruno (Long Beach, New York) |
| ABSTRACT | A floor panel for installation in an aircraft includes a plurality of thermoplastic C-shaped stringers, a consolidated thermoplastic deltoid filler, a thermoplastic upper facing sheet, and a thermoplastic lower facing sheet. The stringers are disposed in a parallel arrangement with one another. The deltoid filler is disposed within a longitudinally-extending notch defined by a pair of adjacent stringers. The upper facing sheet covers an upper surface of the stringers and the deltoid filler. The lower facing sheet covers a lower surface of the stringers and the deltoid filler. The stringers, the deltoid filler, and the upper and lower facing sheets are integrally consolidated forming a unitary construction. |
| FILED | Tuesday, January 09, 2024 |
| APPL NO | 18/407910 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 65/02 (20130101) Aeroplanes; Helicopters B64C 1/18 (20130101) Original (OR) Class B64C 2001/0072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150185 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Xiaolong Liu (Ithaca, New York) |
| ABSTRACT | The invention relates to multi-atomic layer borophene and a method of synthesizing multi-atomic layer borophene. The multi-atomic layer borophene comprises bilayer (BL) borophene. The BL borophene is BL-α borophene comprising two covalently bonded α-phase borophene monolayers and being metallic and in form of a highly faceted island with a six-fold symmetric Moiré superlattice surrounded by full-coverage intermixed SL v1/5 and v1/6 borophene. The BL-α borophene nucleates and emerges at intersections of multiple SL borophene domains. The synthesizing method includes depositing boron on a substrate with atomically flat terraces at a temperature in an ultrahigh vacuum (UHV) chamber to grow multi-atomic layer borophene beyond a full coverage of single-atomic layer (SL) borophene. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 18/281648 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 35/023 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/20 (20130101) C01P 2004/04 (20130101) C01P 2004/20 (20130101) C01P 2006/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150322 | VANKAYALAPATI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Biolexis Therapeutics, Inc. (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hariprasad VANKAYALAPATI (Sandy, Utah); Zhaoliang LI (Salt Lake City, Utah); Kyle MEDLEY (American Fork, Utah); Dongqing YAN (Salt Lake City, Utah); David J. BEARSS (Alpine, Utah) |
| ABSTRACT | or a salt (e.g., pharmaceutically acceptable salt) or stereoisomer thereof, wherein X, Y, R1a, R1b, R2, R3, R4s, R5, p, and n are as defined herein. Use of the compounds as a component of a pharmaceutical compositions and methods for their use are also provided. |
| FILED | Thursday, April 06, 2023 |
| APPL NO | 18/296935 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 403/04 (20130101) Original (OR) Class C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150392 | HAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongran HAN (Cambridge, Massachusetts); Hao YAN (Chandler, Arizona) |
| ABSTRACT | Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein. |
| FILED | Monday, July 31, 2023 |
| APPL NO | 18/228604 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 21/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150438 | WESTENDORF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn WESTENDORF (Vancouver, Canada); Stefanie ZENTELIS (Vancouver, Canada); Krithika MUTHURAMAN (Toronto, Canada); Kevin JEPSON (Vancouver, Canada); Ester FALCONER (North Vancouver, Canada); John MASCOLA (Bethesda, Maryland); Barney GRAHAM (Bethesda, Maryland); Kizzmekia CORBETT (Bethesda, Maryland); Julie LEDGERWOOD (Bethesda, Maryland); Lingshu WANG (Bethesda, Maryland); Olubukola ABIONA (Bethesda, Maryland); Wei SHI (Bethesda, Maryland); Wing-pui KONG (Bethesda, Maryland); Yi ZHANG (Bethesda, Maryland); Bryan Edward JONES (San Diego, California); Denisa FOSTER (San Diego, California); Julian DAVIES (La Jolla, California); Qing CHAI (San Diego, California); Christopher Carl FRYE (Bargersville, Indiana); Ganapathy GOPALRATHNAM (Fishers, Indiana); Jörg HENDLE (San Diego, California); John Michael SAUDER (Carlsbad, California); Jeffrey Streetman BOYLES (Indianapolis, Indiana); Anna PUSTILNIK (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/194105 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 47/02 (20130101) A61K 47/26 (20130101) A61K 47/68 (20170801) A61K 47/183 (20130101) A61K 47/6801 (20170801) A61K 47/6803 (20170801) A61K 47/6841 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150692 | Hussain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saber M. Hussain (Beavercreek, Ohio); Richard Agans (Miamisburg, Ohio); Mark T. Nelson (Oakwood, Ohio); Richard L. Salisbury (Lewisburg, Ohio) |
| ABSTRACT | In accordance with various embodiments of the disclosed subject matter, a system, device and platform for culturing and maintaining tissue representative cellular models combined with active fluidics mimicking body circulation. In combination, multiple chamber devices enable modeling of multi-organ communication, representative of in vivo conditions. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/476464 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/06 (20130101) C12M 23/34 (20130101) C12M 23/38 (20130101) C12M 23/50 (20130101) C12M 23/58 (20130101) C12M 25/02 (20130101) C12M 25/14 (20130101) C12M 29/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150715 | Sasserath et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sciperio, Inc (Orlando, Florida) |
| ASSIGNEE(S) | Sciperio, Inc (Orlando, Florida) |
| INVENTOR(S) | Trevor Sasserath (Orlando, Florida); Janice M. Moser (Oviedo, Florida); Kelly Haupfear (Titusville, Florida); Casey W. Perkowski (Winter Park, Florida); Evan McDowell (Orlando, Florida); Kenneth H. Church (Orlando, Florida) |
| ABSTRACT | A formulation for a culture medium that is specifically designed to supplement a culture of differentiating hematopoietic stem cells (HSCs) with the factors necessary for high density manufacture of red blood cells (RBCs) while only requiring partial medium exchanges on a periodic basis. Further, the present disclosure identifies a factor, iron (III) citrate, also referred to as ferric citrate, that can supplant more commonly utilized sources of biological iron in culture medium for a more stable, more cost-effective medium formulation for superior vertical scalability. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504883 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 29/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0641 (20130101) Original (OR) Class C12N 2500/16 (20130101) C12N 2500/25 (20130101) C12N 2500/32 (20130101) C12N 2500/38 (20130101) C12N 2500/46 (20130101) C12N 2500/60 (20130101) C12N 2500/84 (20130101) C12N 2501/91 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150811 | Abate et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam R. Abate (Daly City, California); John R. Haliburton (San Francisco, California); Freeman Lan (San Francisco, California); Adam R. Sciambi (San Francisco, California) |
| ABSTRACT | Microfluidic methods for barcoding nucleic acid target molecules to be analyzed, e.g., via nucleic acid sequencing techniques, are provided. Also provided are microfluidic, droplet-based methods of preparing nucleic acid barcodes for use in various barcoding applications. The methods described herein facilitate high-throughput sequencing of nucleic acid target molecules as well as single cell and single virus genomic, transcriptomic, and/or proteomic analysis/profiling. Systems and devices for practicing the subject methods are also provided. |
| FILED | Thursday, June 22, 2023 |
| APPL NO | 18/212868 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 25/4338 (20220101) B01F 33/3021 (20220101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 7/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6804 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150817 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Devleena Samanta (Evanston, Illinois); Sasha B. Ebrahimi (DeKalb, Illinois) |
| ABSTRACT | The present disclosure provides a general strategy based on CRISPR and oligonucleotide-detectable marker conjugates that allows sensitive detection of nucleic acid and non-nucleic acid target analytes without stringent temperature requirements. In various aspects, this strategy can be used for rapid and routine detection of viral and bacterial infections, screening of diseases with known biomarkers, and tracking the progression of diseases or response to therapy over time. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/283710 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/16 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) C12Q 1/70 (20130101) C12Q 1/6823 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/922 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151110 | Cross et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Thomas Cross (Waterford, New York); Christopher Walter Falcone (Schenectady, New York); Deepak Trivedi (Halfmoon, New York) |
| ABSTRACT | A tunneling device includes a body assembly, an expander coupled to the body assembly and extending along a longitudinal axis, and a tip coupled to the expander. The expander is disposed between a force transmitter and the tip. The expander is expandable in a direction perpendicular to the longitudinal axis between a first configuration having a first width measured perpendicular to the longitudinal axis and a second configuration having a second width measured perpendicular to the longitudinal axis. The tip has a width measured perpendicular to the longitudinal axis. The first width of the expander is equal to or less than the width of the tip. The force transmitter is configured to deliver a force through the expander to the tip to move the tip in a direction parallel to the longitudinal axis with the expander in the second configuration. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/981940 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 7/26 (20130101) Original (OR) Class E21B 10/322 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151194 | FULLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Jerome K. FULLER (Van Nuys, California); Denise Galindo BURRELL (Culver City, California); Edward V. WAGNER (Long Beach, California); Andrew C. CORTOPASSI (Lakewood, California); Jeffrey Arthur LANG (Torrance, California); Robert B. PAN (Torrance, California) |
| ABSTRACT | An ablative thruster includes a nozzle configured to control a flow of thrust from the satellite. The ablative thruster also includes an ablative surface inside of the nozzle, configured to deflect the thrust at a predefined angle. The ablative surface is configured to ablate-away, leaving un-deflected thrust for a majority of the burn. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 18/053294 |
| CURRENT CPC | Jet-propulsion Plants F02K 1/82 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151292 | Kasprzak |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jan M. Kasprzak (Lexington Park, Maryland) |
| ABSTRACT | A magnetorheological fluid damping system for shock and vibration attenuation, which comprises of an outer cylinder, a piston cylinder partially disposed within the outer cylinder, a metering pin disposed within the outer cylinder and partially disposed within the piston cylinder, and an electromagnetic valve having two opposite ends and attached to the piston cylinder. The electromagnetic valve is completely disposed within the outer cylinder. The electromagnetic valve comprises of valve casing with a cavity, an annular electric coil disposed within the cavity of the valve casing, two layers of cladding attached on the opposite ends of the electromagnetic valve, and magnetorheological fluid disposed within the outer cylinder. The piston cylinder and metering pin are partially immersed within the magnetorheological fluid, while and the valve casing is attached to the piston cylinder. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/981735 |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 9/537 (20130101) Original (OR) Class F16F 2224/045 (20130101) F16F 2226/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151343 | Trivedi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deepak Trivedi (Halfmoon, New York); Andrew Thomas Cross (Waterford, New York); Christopher Walter Falcone (Schenectady, New York) |
| ABSTRACT | A navigation apparatus for use in navigating a pipe having a sidewall defining an interior cavity is provided. The navigation apparatus includes a body assembly having a first end and a second end and configured to move through the interior cavity of the pipe. The navigation apparatus also includes a channel defining a fluid passageway extending at least partly between the first end and the second end of the body assembly, an inlet for fluid from the interior cavity of the pipe to enter the fluid passageway, and an outlet for the fluid to exit the fluid passageway and return to the interior cavity of the pipe. The channel is configured to allow the fluid to flow through the fluid passageway and from the first end of the body assembly to the second end of the body assembly as the body assembly moves through the interior cavity of the pipe. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/981934 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 55/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151344 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yew Teck Tan (Schenectady, New York); Deepak Trivedi (Halfmoon, New York); Steven Robert Gray (Niskayuna, New York); Pei-Hsin Kuo (Alplaus, New York); Alexander Kyle Duncan (Niskayuna, New York) |
| ABSTRACT | A system includes a navigation apparatus and controller. The navigation apparatus includes a body assembly that includes a plurality of pneumatic or artificial muscles that are configured to interact with a sidewall of the conduit and move the body assembly through the conduit. The plurality of pneumatic or artificial muscles are independently actuated to steer the body assembly. The navigation apparatus also includes a sensor array coupled to the body assembly. The sensor array is positioned to interact with the sidewall of the conduit and provide signals as the body assembly moves through the interior cavity. The controller is communicatively coupled to the sensor array and configured to determine a characteristic of the conduit based on the signals provided by the sensor array. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/981955 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 55/38 (20130101) F16L 55/48 (20130101) Original (OR) Class F16L 2101/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151511 | Pero |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael J. Pero (King George, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Michael J. Pero (King George, Virginia) |
| ABSTRACT | A compact modular mount is provided for mechanically compensating for focal distance change on a table due to thermal expansion. The mount includes first and second rings, a plurality of spacers and a plurality of bolts. The second material has a multi-factor higher coefficient of thermal expansion than the first material. Each of the first and second rings has a plurality of holes for receiving the bolts. The spacers each include symmetrically arranged plates hinging to adjacent segments. The bolts maintain angular alignment of the rings. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/377235 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02049 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151617 | Turoff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Riley D. Turoff (King George, Virginia); Dylan J. Ciraco (Fredericksburg, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Riley D. Turoff (King George, Virginia); Dylan J. Ciraco (Fredericksburg, Virginia) |
| ABSTRACT | A test fixture is provided for containing a pair of test samples (i.e., sample pair) that contact each other along an interface. The fixture receives exposure to laser emission for radiative heating while providing compression to the sample pair. The text fixture includes a housing, an isolation container, and a compressor. The housing has an axial cavity with annular cross-sections including an internal helical thread portion and a window for receiving the laser emission. The isolation container receives the sample pair. The container inserts into the axial cavity and including an opening for disposition adjacent to the window. The compressor has circular cross-sections for insertion into the axial cavity and includes an external helical thread portion for engaging the internal helical thread portion of the housing. Axial pressure applies to the isolation container by turning the compressor inside the axial cavity. The isolation container provides thermal insulation from the housing and the compressor. In additional embodiments, the isolation container comprises a cup with the opening to isolate the sample pair from the housing, and a washer to isolate the sample pair from the compressor. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 17/980805 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 9/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151645 | Diebold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric D. Diebold (Los Angeles, California); Bahram Jalali (Los Angeles, California); Brandon Buckley (Los Angeles, California) |
| ABSTRACT | Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques. |
| FILED | Monday, June 26, 2023 |
| APPL NO | 18/214292 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/05 (20130101) G01N 21/6408 (20130101) Original (OR) Class G01N 21/6458 (20130101) G01N 21/6486 (20130101) G01N 2021/6415 (20130101) G01N 2021/6419 (20130101) G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/0076 (20130101) G02B 21/0084 (20130101) G02B 27/1006 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151682 | QING |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Quan QING (Chandler, Arizona) |
| ABSTRACT | Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 18/550881 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 2300/0645 (20130101) B01L 2300/0896 (20130101) B01L 2400/0415 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151717 | Kidwell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Kidwell (Alexandria, Virginia) |
| ABSTRACT | The present invention provides for a method of delaying application of chemical reagents in a lateral-flow immunoassay. A chemistry release fiber comprising a permeable membrane and a chemical release agent is used to delay chemical reagent delivery to the indicator of a lateral-flow immunoassay. Also disclosed is the related release system for delaying application of chemical reagents in a lateral-flow immunoassay. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413506 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/29 (20130101) G01N 21/78 (20130101) G01N 33/525 (20130101) G01N 33/54388 (20210801) Original (OR) Class G01N 2201/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240151864 — TUNNELING AND NAVIGATION SYSTEM INCLUDING DISTRIBUTED COMMUNICATION AND SENSING SYSTEM
| US 20240151864 | Wallace et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirk D. Wallace (Glenville, New York); Emad A. Andarawis (Ballston Lake, New York); Deepak Trivedi (Halfmoon, New York); Brian J. Scherer (Schenectady, New York) |
| ABSTRACT | A system includes a tunneling device including a body assembly configured to move through an interior cavity of a tunnel. The system also includes a distributed communication and sensing system and a controller. The distributed communication and sensing system includes a first beacon coupled to the body assembly, and a second beacon positioned outside of the tunnel. The second beacon is communicatively coupled to the first beacon. The controller is configured to compare a first signal transmitted by the first beacon to a second signal transmitted by the second beacon, determine an environmental characteristic of the tunnel based on the first signal and the second signal, and determine an operating parameter for the tunneling device based on the environmental characteristic. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/981981 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/0654 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 1/18 (20130101) G01V 1/162 (20130101) Original (OR) Class G01V 3/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240152143 | Blankespoor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Boston Dynamics, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Blankespoor (Arlington, Massachusetts); Gabriel Nelson (Waltham, Massachusetts); Neil Neville (Waltham, Massachusetts) |
| ABSTRACT | A method for estimating a ground plane of a legged robot includes determining one or more physical contact points of the legged robot based on first sensor information of the legged robot, determining one or more virtual contact points of the legged robot based on second sensor information of the legged robot, determining a ground plane estimation of the ground surface based on both the one or more physical contact points and the one or more virtual contact points, and controlling a pose of the legged robot based on the ground plane estimation. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/414181 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) B25J 9/1615 (20130101) B25J 9/1694 (20130101) B25J 9/1697 (20130101) Motor Vehicles; Trailers B62D 57/032 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) Original (OR) Class Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240152540 | Cadigan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Cadigan (San Diego, California); Martin Graciarena (Belmont, California) |
| ABSTRACT | In an example, a method for adapting a machine learning model includes receiving first input data; choosing a first set of unlabeled textual spans in the first input data, wherein the chosen first set of unlabeled textual spans is associated with a first domain; labeling the chosen first set of unlabeled textual spans to generate a labeled first set of textual spans; categorizing the labeled first set of textual spans to generate a categorized labeled first set of textual spans; receiving second input data; choosing a second set of unlabeled textual spans, wherein the second set of unlabeled textual spans is associated with a second domain; and adapting the machine learning model to the second domain based on the categorized second set of unlabeled textual spans that is generated based on the categorized labeled first set of textual spans. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472761 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/353 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240152744 | Mireshghallah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatemehsadat Mireshghallah (La Jolla, California); Hadi Esmaeilzadeh (La Jolla, California); Mohammadkazem Taram (La Jolla, California) |
| ABSTRACT | Described are methods, devices and applications for learning noise distribution on information from any data processing method. In an embodiment of the described technology, a method includes determining an amount of shredding used in a shredding operation by which source data is converted into shredded data, and transferring the shredded data over an external network to a remote server for a data processing task. The shredding reduces the information content and incurs a limited degradation to an accuracy of the data processing task due to the shredding operation. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/073143 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153115 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Shaoxiong Wang (Cambridge, Massachusetts); Branden Romero (Brighton, Massachusetts); Yu She (West Lafayette, Indiana); Edward Adelson (Winchester, Massachusetts) |
| ABSTRACT | Retrographic sensors described herein may provide smaller sensors capable of high-resolution three-dimensional reconstruction of an object in contact with the sensor. Such sensors may be used by robots for work in narrow environments, fine manipulation tasks, and other applications. To provide a smaller sensor, a reduced number of light sources may be provided in the sensor in some embodiments. For example, three light sources, two light sources, or one light source, may be used in some sensors. When fewer light sources are provided, full color gradient information may not be provided. Instead, the missing gradients in one direction or other information related to a three-dimensional object in contact with the sensor may be determined using gradients in a different direction that were provided by the real data. This may be done using a trained statistical model, such as a neural network, in some embodiments. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 18/280940 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/50 (20170101) Original (OR) Class G06T 15/00 (20130101) Image or Video Recognition or Understanding G06V 10/141 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153230 | ZHENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaiyu ZHENG (Providence, Rhode Island); Stefanie TELLEX (Providence, Rhode Island) |
| ABSTRACT | A method includes, in an automated machine equipped with one or more camera-based object detectors, receiving human-provided information or information inferred from point cloud observations regarding target locations, maintaining information states regarding the target locations through a probability distribution structured as an octree, initializing the information states based on point cloud observations, updating the information states based on object detection observations or point cloud observations, determining a search region occupancy through constructing an octree-based occupancy grid based on point cloud observations, and using ray-tracing to determine visibility at three dimensional locations within the search region. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500768 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1697 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 15/06 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) Original (OR) Class G06V 2201/07 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153394 | Schroeder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradford Schroeder (Orlando, Florida); Jason Hochreiter (Cocoa, Florida) |
| ABSTRACT | A computer software suite for inspecting data from an external system and applying user-specified conditional triggers to generate and present augmentations to a user, the suite comprising an editing module and a runtime module. The editing module is for the user to inspect and select data via a general purpose computer, while the editing module is manipulatable based on the data. The editing module can further construct logic for conditionally processing the interface manipulated data. The runtime module is for displaying visual and aural elements based on the logic specified by the user in the editing module. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/983918 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153763 | Myers-Ward et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Government of the United States of America, as Represented by the Secretary of the Navy (Arlington, Virginia); ROHM Co. Ltd. (Kyoto, Japan) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Government of the United States of America, as Represented by the Secretary of the Navy (Arlington, Virginia); ROHM Co. Ltd. (Kyoto, Japan) |
| INVENTOR(S) | Rachael L. Myers-Ward (Arlington, Virginia); Jeehwan Kim (Cambridge, Massachusetts); Kuan Qiao (Cambridge, Massachusetts); Wei Kong (Cambridge, Massachusetts); David Kurt Gaskill (Alexandria, Virginia); Takuji Maekawa (Kyoto, Japan); Noriyuki Masago (Kyoto, Japan) |
| ABSTRACT | Systems and methods for growth of silicon carbide over a layer comprising graphene and/or hexagonal boron nitride, and related articles, are generally described. In some embodiments, a SiC film is fabricated over a layer comprising graphene and/or hexagonal boron nitride, which in turn is disposed over a substrate. The layer and/or the substrate may be lattice-matched with the SiC film to reduce defect density in the SiC film. The fabricated SiC film may then be removed from the substrate via, for example, a stressor attached to the SiC film. In certain cases, the layer serves as a reusable platform for growing SiC films and also serves a release layer that allows fast, precise, and repeatable release at the layer surface. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/486471 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0262 (20130101) H01L 21/02378 (20130101) H01L 21/02389 (20130101) H01L 21/02433 (20130101) H01L 21/02444 (20130101) H01L 21/02458 (20130101) H01L 21/02502 (20130101) H01L 21/02529 (20130101) Original (OR) Class H01L 21/02598 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240148273 | Gouma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Pelagia I. Gouma (Columbus, Ohio); Matthew Exline (Columbus, Ohio); Andrew Bowman (Milford Center, Ohio); Milutin Stanacevic (Smithtown, New York) |
| ABSTRACT | A method for evaluating for the presence of the COVID disease by detecting one or more biomarkers using a breathalyzer. The breath sample taken from the subject is passed over a sensor which changes resistance in the presence of nitric oxide as a function of concentration. The resistance pattern of the subject having the COVID disease will have a distinct shape, approximating the appearance of the small Greek letter omega (ω). Test results can be generated in less than a minute. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/543397 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/082 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/497 (20130101) G01N 2033/4977 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148523 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhi Yang (Minneapolis, Minnesota); Anh Tuan Nguyen (Minneapolis, Minnesota); Diu Khue Luu (Minneapolis, Minnesota) |
| ABSTRACT | A neurostimulator incorporating a novel chip design that uses the principle of redundant signal crossfiring to overcome electronic component mismatch error in general and transistor mismatch error in particular, to yield superior quality neurostimulation signal generation, useful in enhancing the bidirectional human-machine interface in prosthesis operation for the restoration of somatosensation for an amputee; and an improvement thereof additionally comprising a digital-to-analog converter device, that includes a number of unit cells, each unit cell being associated with a unit cell size indicating manufacturing specifications of the unit cell, and that further includes a plurality of switches, each being coupled to a component, and an output electrode coupled to the plurality of switches, and wherein the digital-to-analog converter device is configured to output an output signal at the output electrode. |
| FILED | Tuesday, December 26, 2023 |
| APPL NO | 18/396610 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) Original (OR) Class A61F 2/583 (20130101) A61F 2002/6827 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240149541 — Novel Liquid Matrix Impregnation Method and Apparatus for Composite Prepreg Production
| US 20240149541 | HSIAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF SOUTH ALABAMA (MOBILE, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KUANG-TING HSIAO (SPANISH FORT, Alabama); SEBASTIAN KIRMSE (ATLANTA, Georgia) |
| ABSTRACT | A process for continuous production of z-threaded fiber reinforced polymer composites. The process includes providing a pre-formed fiber fabric including a plurality of fibers and a pre-formed, solidified film having a film thickness dimension, wherein the film includes a heat-meltable base matrix material in combination with a plurality of z-aligned nanofibers disposed within the base matrix material. The film and fiber fabric are advanced in layered relation through a constricting matrix transfer station, wherein the fiber fabric is heated to a temperature at or above the melting point of the base matrix material and the base matrix material progressively melts at an interface with the fabric face and flows with the nanofibers into the fiber fabric in the fabric thickness dimension as the film and fiber fabric move through the matrix transfer station. The matrix transfer station includes a constricting processing gap urging the film towards the fiber fabric through at least a portion of the matrix transfer station. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 18/549501 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/24 (20130101) B29C 70/50 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/243 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150185 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Xiaolong Liu (Ithaca, New York) |
| ABSTRACT | The invention relates to multi-atomic layer borophene and a method of synthesizing multi-atomic layer borophene. The multi-atomic layer borophene comprises bilayer (BL) borophene. The BL borophene is BL-α borophene comprising two covalently bonded α-phase borophene monolayers and being metallic and in form of a highly faceted island with a six-fold symmetric Moiré superlattice surrounded by full-coverage intermixed SL v1/5 and v1/6 borophene. The BL-α borophene nucleates and emerges at intersections of multiple SL borophene domains. The synthesizing method includes depositing boron on a substrate with atomically flat terraces at a temperature in an ultrahigh vacuum (UHV) chamber to grow multi-atomic layer borophene beyond a full coverage of single-atomic layer (SL) borophene. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 18/281648 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 35/023 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/20 (20130101) C01P 2004/04 (20130101) C01P 2004/20 (20130101) C01P 2006/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150392 | HAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongran HAN (Cambridge, Massachusetts); Hao YAN (Chandler, Arizona) |
| ABSTRACT | Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein. |
| FILED | Monday, July 31, 2023 |
| APPL NO | 18/228604 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 21/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150520 | Coates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York); University of Pittsburgh - of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Yiye Lu (Ithaca, New York); Tara Y. Meyer (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods for regioselective ring-opening polymerization of unsymmetrical cyclic diester monomers, polymers, which may be made by the methods, and uses of same. Monomers may include cyclic hydroxy-acid dimers, such as, for example, 3-methyl glycolide and the like. Polymerization initiators may include chiral metal alkoxide initiators, such as, for example, (SalBinam)Al-01Pr initiators and the like. Polymers may include polyesters, such as, for example, poly(lactic-co-glycolic acid) (PLGA) and the like, with 90% or greater regioselectivity for alternating ester units (e.g., glycolic unit-lactic unit (G—L) linkages). Polymers may be utilized for substained or targeted drug delivery vehicles, scaffolding for tissue engineering, bioabsorbable sutures, or the like. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 18/546039 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) Original (OR) Class C08G 63/84 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150635 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brandeis University (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Grace GD Han (Belmont, Massachusetts); Yuran Shi (Waltham, Massachusetts) |
| ABSTRACT | The present invention relates to a compound of Formula (I) where (II), (III), R1, R2, R3, R4, R5, Q, and Z are as described herein and compositions containing this compound. The present invention also relates to a methods of making a compound of Formula (I) and methods of using one or more of these compounds as a thermal-storage material thermal-storage device and. Methods of storing energy are also described. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 18/263904 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150687 | Roop et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Berkeley Brewing Science, Inc. (Oakland, California) |
| ASSIGNEE(S) | Berkeley Brewing Science, Inc. (Oakland, California) |
| INVENTOR(S) | Jeremy Roop (Berkeley, California); Charles Denby (Berkeley, California); Rachel Li (Berkeley, California); Nicholas Harris (Oakland, California) |
| ABSTRACT | Provided herein are genetically modified yeast cells that recombinantly expresses a gene encoding a mutant beta-lyase. Also provided are methods of producing fermented products and methods of producing ethanol. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/768257 |
| CURRENT CPC | Beer; Preparation of Beer by Fermentation; Preparation of Malt for Making Beer; Preparation of Hops for Making Beer C12C 11/003 (20130101) C12C 12/004 (20130101) Original (OR) Class C12C 12/006 (20130101) C12C 2200/05 (20130101) Wine; Preparation Thereof; Alcoholic Beverages; Preparation of Alcoholic Beverages Not Provided for in Subclasses C12C or C12H C12G 1/0203 (20130101) C12G 2200/05 (20130101) C12G 2200/11 (20130101) C12G 2200/15 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/18 (20130101) C12N 9/88 (20130101) C12N 15/81 (20130101) C12N 2800/102 (20130101) Enzymes C12Y 404/01013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150803 | OAKLEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Berl OAKLEY (Lawrence, Kansas); Travis J. WILLIAMS (Los Angeles, California); Yi-Ming CHIANG (Los Angeles, California); Clay C. WANG (Los Angeles, California); Yuhao CHEN (Los Angeles, California); Swati BIJLANI (Los Angeles, California); C. Elizabeth OAKLEY (Lawrence, Kansas); Christian Anthony RABOT (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California); UNIVERSITY OF KANSAS (Lawrence, Kansas) |
| INVENTOR(S) | Berl OAKLEY (Lawrence, Kansas); Travis J. WILLIAMS (Los Angeles, California); Yi-Ming CHIANG (Los Angeles, California); Clay C. WANG (Los Angeles, California); Yuhao CHEN (Los Angeles, California); Swati BIJLANI (Los Angeles, California); C. Elizabeth OAKLEY (Lawrence, Kansas); Christian Anthony RABOT (Los Angeles, California) |
| ABSTRACT | A non-human organism for upgrading intermediate oxidation products formed by catalytic degradation of alkanes or polystyrenes is provided. The non-human organism is genetically modified to convert the intermediate oxidation products to secondary metabolites, and in particular to include a positive feedback loop construction in the promotor system. A method includes steps of catalytically degrading alkanes or polystyrene in an oxidizing environment to form intermediate products with one or more catalysts and contacting the intermediate products with the non-human organism such that intermediate oxidation products are converted to secondary metabolites. |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/380447 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/24 (20130101) B01J 31/0244 (20130101) B01J 31/0247 (20130101) B01J 31/2208 (20130101) B01J 2231/70 (20130101) B01J 2531/72 (20130101) B01J 2531/842 (20130101) B01J 2531/845 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1051 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) C12P 17/162 (20130101) Original (OR) Class Enzymes C12Y 204/01183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150811 | Abate et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam R. Abate (Daly City, California); John R. Haliburton (San Francisco, California); Freeman Lan (San Francisco, California); Adam R. Sciambi (San Francisco, California) |
| ABSTRACT | Microfluidic methods for barcoding nucleic acid target molecules to be analyzed, e.g., via nucleic acid sequencing techniques, are provided. Also provided are microfluidic, droplet-based methods of preparing nucleic acid barcodes for use in various barcoding applications. The methods described herein facilitate high-throughput sequencing of nucleic acid target molecules as well as single cell and single virus genomic, transcriptomic, and/or proteomic analysis/profiling. Systems and devices for practicing the subject methods are also provided. |
| FILED | Thursday, June 22, 2023 |
| APPL NO | 18/212868 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 25/4338 (20220101) B01F 33/3021 (20220101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 7/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6804 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150830 | Aiden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Erez Lieberman Aiden (Houston, Texas); Galina Aglyamova (Houston, Texas); Ivan Bochkov (Houston, Texas); Olga Dudchenko (Houston, Texas); Saul Godinez (Houston, Texas); Huiya Gu (Houston, Texas); Ragini Mahajan (Houston, Texas); Suhas Rao (Stanford, California); Andreas Gnirke (Cambridge, Massachusetts); Elena Stamenova (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erez Lieberman Aiden (Houston, Texas); Galina Aglyamova (Houston, Texas); Ivan Bochkov (Houston, Texas); Olga Dudchenko (Houston, Texas); Saul Godinez (Houston, Texas); Huiya Gu (Houston, Texas); Ragini Mahajan (Houston, Texas); Suhas Rao (Stanford, California); Andreas Gnirke (Cambridge, Massachusetts); Elena Stamenova (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed are methods for obtaining genome scale and fully phased epigenetic maps in a cell. The method enables maintaining intact chromatin structure and interrogating chromatin structure using chromatin accessibility maps. DNA contacts are used to fully phase the epigenetic and chromatin contact maps. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501637 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2600/16 (20130101) C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150903 | Nazemi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammadreza Nazemi (Atlanta, Georgia); Mostafa A. El-Sayed (Atlanta, Georgia) |
| ABSTRACT | A system for forming ammonia including an anode, a cathode in electrical communication with the anode, and a catalyst material positioned in an electrical communication pathway between the cathode and the anode, the catalyst material including nanoparticles including at least one of a conductor and a semiconductor, the nanoparticles having an interior cavity, wherein the system is configured to use nitrogen and water to generate ammonia. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/543181 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/00 (20130101) Original (OR) Class C25B 1/27 (20210101) C25B 9/65 (20210101) C25B 11/081 (20210101) C25B 15/02 (20130101) C25B 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151144 | Haggerty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Haggerty (Goleta, California); Elliot Hawkes (Goleta, California) |
| ABSTRACT | A soft vine robot includes a main body configured as a tube inverted back inside itself to define a pressure channel, such that when the channel is pressurized, the main body everts, and inverted material of the main body everts and passes out of a tip at a distal end of the main body. A reeling mechanism is controlled by a reeling motor, the reeling mechanism being within the tube and being configured to actively feed the inverted material to provide or assist eversion and to actively retract extended material of the main body back. Control and communications electronics control the reeling motor. T reeling mechanism can include a steering mechanism with a bending axis controlled by a steering motor. By actively supplying eversion or inversion forces in the robot body, the soft vine robot can grow with reduced pressure compared to base reeled robots. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 18/549382 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/142 (20130101) B25J 18/06 (20130101) B25J 18/025 (20130101) B25J 19/023 (20130101) Machines or Engines, in General or of Positive-displacement Type, e.g Steam Engines F01B 19/04 (20130101) Original (OR) Class Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151667 | Labanowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sonora Magnetics, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominic Labanowski (Berkeley, California); Sayeef Salahuddin (Walnut Creek, California) |
| ABSTRACT | A system and method for an acoustically driven ferromagnetic resonance (ADFMR) based sensor including: a power source, that provides an electrical signal to power the system; and an ADFMR circuit, sensitive to electromagnetic fields, wherein the ADFMR circuit comprises an ADFMR device. The system functions to detect and measure external electromagnetic (EM) fields by measuring a perturbation of the electrical signal through the ADFMR circuit due to the EM fields. |
| FILED | Monday, July 17, 2023 |
| APPL NO | 18/222543 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/10 (20130101) Original (OR) Class Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 5/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151683 | SU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiao SU (Champaign, Illinois); Nayeong KIM (Champaign, Illinois); Johannes ELBERT (Urbana, Illinois) |
| ABSTRACT | The design of electrochemically responsive halogen donors in redox-active polymer for switchable electrosorption and release of anions. A redox-active group such as ferrocene acts as an electron-withdrawing group, facilitating the delocalization of the electrons on the halogen atom. Upon the oxidation of the ferrocene moiety, the halogen atom forms a partial-positive charge (σ-hole) on the elongation of the C—I bond, resulting in strong binding with anions in cooperation with the hydrogen bonds on the cyclopentadienyl ring on the oxidized ferrocene. During reduction of ferrocene, halogen bonding is deactivated, releasing the bound anions reversibly. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/382796 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 130/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/333 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240152601 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ziming Zhao (Williamsville, New York); Md Armanuzzaman (Buffalo, New York) |
| ABSTRACT | A system and method for building a trusted execution environment for software programs in a system-on-chip (SOC) field programmable gate array (FPGA). A processing system is located on the semiconductor substrate of the SOC which includes one or more processors, and the FPGA is in communication with the processing system and implements one more soft processors to create one or more trusted execution environments for a software program process to execute within. Each trusted execution environment is configured to allow a software program to execute in a secure manner wherein the software program is isolated from, at least, the full plurality of computing resources of the SOC. The system and method can be used with SOCs on servers hosting remote computing. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504528 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/53 (20130101) Original (OR) Class G06F 21/575 (20130101) G06F 2221/033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240152742 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao Li (Lawrence, Kansas); Judy Z. Wu (Lawrence, Kansas) |
| ABSTRACT | A neuromorphic computing circuit includes a plurality of memristors that function as synapses. The neuromorphic computing circuit also includes a superconducting quantum interference device (SQUID) coupled to the plurality of memristors. The SQUID functions as a neuron such that the plurality of memristors and the SQUID form a neural unit of the neuromorphic computing circuit. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 18/280530 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/065 (20230101) Original (OR) Class G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240152744 | Mireshghallah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatemehsadat Mireshghallah (La Jolla, California); Hadi Esmaeilzadeh (La Jolla, California); Mohammadkazem Taram (La Jolla, California) |
| ABSTRACT | Described are methods, devices and applications for learning noise distribution on information from any data processing method. In an embodiment of the described technology, a method includes determining an amount of shredding used in a shredding operation by which source data is converted into shredded data, and transferring the shredded data over an external network to a remote server for a data processing task. The shredding reduces the information content and incurs a limited degradation to an accuracy of the data processing task due to the shredding operation. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/073143 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153229 | BUCKLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); Mark A. BUCKLER (Wenham, Massachusetts); Vladimir VALTCHINOV (Boston, Massachusetts); David S. PAIK (Moon Bay, California) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/309903 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) Original (OR) Class G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153290 | Fathi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Pointivo, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Habib Fathi (Atlanta, Georgia); Miguel M. Serrano (Marietta, Georgia); Bradden John Gross (Atlanta, Georgia); Daniel L. Ciprari (Atlanta, Georgia) |
| ABSTRACT | Examples of various method and systems are provided for information extraction from scene information. 2D image information can be generated from 2D images of the scene that are overlapping at least part of one or more object(s). The 2D image information can be combined with 3D information about the scene incorporating at least part of the object(s) to generate projective geometry information. Clustered 3D information associated with the object(s) can be generated by partitioning and grouping 3D data points present in the 3D information. The clustered 3D information can be used to provide, e.g., measurement information, dimensions, geometric information, and/or topological information about the object(s). Segmented 2D information can also be generated from the 2D image information. Validated 2D and 3D information can be produced by cross-referencing between the projective geometry information, clustered 3D information, and/or segmented 2D image information, and used to label the object(s) in the scene. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/389076 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/23 (20230101) Image Data Processing or Generation, in General G06T 7/55 (20170101) G06T 17/00 (20130101) G06T 2207/10028 (20130101) Image or Video Recognition or Understanding G06V 20/10 (20220101) G06V 20/64 (20220101) G06V 20/70 (20220101) Original (OR) Class G06V 20/647 (20220101) G06V 2201/12 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153715 | Rajagopalan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramakrishnan Rajagopalan (DuBois, Pennsylvania); Hossein Hamedi (University Park, Pennsylvania); Clive A. Randall (University Park, Pennsylvania) |
| ABSTRACT | A method of fabricating a capacitor can include prelithiating a carbon material to form a first layer for the capacitor. The first layer including an anode or being an anode layer. A second layer can be positioned between the first layer and a third layer. The second layer can be or include a membrane and the third layer can be or include a cathode. The third layer can include activated carbon or utilize activated carbon as a cathode. Capacitors can be formed by use of this method and devices can utilize such capacitors. Instead of relying on lithium in metallic form, a carbon material can be prelithiated to include lithium ions therein to form an anode for the LIC that avoids use of lithium foil or lithium powder in the LIC and also avoid use of lithium in a metallic form in the LIC. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 18/264145 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/06 (20130101) Original (OR) Class H01G 11/34 (20130101) H01G 11/50 (20130101) H01G 11/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240154626 | Wesel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Richard D. Wesel (Manhattan Beach, California); Linfang Wang (Los Angeles, California); Sean Chen (Los Angeles, California); Dariush Divsalar (Pacific Palisades, California); Jonathan Nguyen (Los Angeles, California) |
| ABSTRACT | Neural Normalized MinSum (N-NMS) decoding for improving frame error rate (FER) performance on linear block codes over conventional normalized MinSum (NMS). Dynamic multiplicative weights are assigned to each check-to-variable message in each iteration to efficiently provide training parameters of N-NMS that support N-NMS for longer block lengths. Embodiment are described for neural two-dimensional normalized MinSum (N-2D-NMS) decoders requiring fewer training parameters. The N-2D-NMS approaches for example use the same weight for edges with the same check and/or variable node degree. Simulation results indicate that that this LDPC decoding performs similarly to previous techniques while substantially reducing the amount of training necessary. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/240162 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 13/1111 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240154721 | Wesel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Richard Wesel (Manhattan Beach, California); Linfang Wang (Los Angeles, California); Dan Song (Los Angeles, California); Felipe Areces (Los Angeles, California) |
| ABSTRACT | Communication systems and methods are disclosed that utilize Probability Amplitude Shaping (PAS) and Trellis Coded Modulation (TCM) to transmit short block-length messages. While capacity-approaching codes, such as Low Density Parity Check (LDPC) codes, Turbo codes, and Polar codes, can achieve data rates approaching the Shannon limit at large block-lengths, the performance of these codes can deteriorate dramatically at short block-lengths. Communication systems configured in accordance with various embodiments of the invention can utilize classical codes to encode short block-length messages to achieve communication rates exceeding Polyanskiy's Random Coding Union bound. In several embodiments, message bits are transmitted using a TCM system in which message bits that have been previously encoded by an error detection code are encoded using a convolutional code (CC). In a number of embodiments, the error detection code and the CC are obtained via a joint optimization with respect to a Frame Error Rate bound. |
| FILED | Wednesday, November 01, 2023 |
| APPL NO | 18/500000 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 1/006 (20130101) Original (OR) Class H04L 1/0061 (20130101) H04L 1/206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240148910 | Rosenzweig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zeev Rosenzweig (Baltimore, Maryland); Marcin Ptaszek (Baltimore, Maryland); Connor Riahin (Baltimore, Maryland); Adam Meares (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to nanoscale polymer dots (Pdots) that include strongly light absorbing semiconducting polymer nanoparticles doped with near-IR emitting dyes. The polymer functions as an antenna and transfers the excitation energy to the doped near-IR emitting dye molecules, which function as the emitting entity. The resulting Pdots feature very bright near-IR emission with emission wavelength tunability, high water solubility, and stability in biological solutions. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0045 (20130101) Original (OR) Class A61K 49/0067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149258 | Shultz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mary Jane Shultz (Natick, Massachusetts); Nicholas J. Anderson (Boston, Massachusetts); Tongzhou Xu (Beijing, China PRC); Patrick Bisson (Lowell, Massachusetts) |
| ABSTRACT | Photocatalysts and methods of making and using the same are disclosed. The photocatalyst includes a TIO2 ultra-nanoparticle having a single Fe, Co, Mn, Cr, or W atom positioned as an engineered defect within the particle and a single metal catalyst atom bound proximal to the single Fe, Co, Mn, Cr, or W atom. The method of making the photocatalyst includes generating a plurality of ultra-nano TIO2 particles, each having a single Fe, Co, Mn, Cr, or W atom positioned as an engineered defect within the particle. The method further includes photodepositing a single metal catalyst atom proximal to the single Fe, Co, Mn, Cr, or W atom for at least a portion of the ultra-nano TIO2 particles, thereby creating the disclosed photocatalyst. The single metal catalyst atom is in a positive oxidation state and can be Pt, Pd, Ir, Ru, Rh, Os, Re, Au, Ni, Zn, or Cu. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 18/255535 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/063 (20130101) B01J 23/26 (20130101) B01J 23/30 (20130101) B01J 23/34 (20130101) B01J 23/36 (20130101) B01J 23/72 (20130101) B01J 23/80 (20130101) B01J 23/685 (20130101) B01J 23/687 (20130101) B01J 23/688 (20130101) B01J 23/755 (20130101) B01J 23/866 (20130101) B01J 23/868 (20130101) B01J 23/888 (20130101) B01J 23/6522 (20130101) B01J 23/6527 (20130101) B01J 23/6562 (20130101) B01J 23/8892 (20130101) B01J 23/8896 (20130101) B01J 23/8906 (20130101) B01J 35/004 (20130101) Original (OR) Class B01J 35/0013 (20130101) B01J 37/0215 (20130101) B01J 37/345 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149304 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sortera Technologies, Inc. (Markle, Indiana) |
| ASSIGNEE(S) | Sortera Technologies, Inc. (Markle, Indiana) |
| INVENTOR(S) | Nalin Kumar (Fort Wayne, Indiana); Manuel Gerardo Garcia, JR. (Austin, Texas); Isha Kamleshbhai Maun (Arlington, Texas) |
| ABSTRACT | A material sorting system sorts materials utilizing an x-ray fluorescence and/or a vision system that implements a machine learning system in order to identify or classify each of the materials, which are then sorted into separate groups based on such an identification or classification determining that the materials are composed of either wrought aluminum, extruded aluminum, or cast aluminum. The system is capable of sorting between cast aluminum alloys and also between wrought aluminum alloys. |
| FILED | Monday, January 15, 2024 |
| APPL NO | 18/412987 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149353 | Shah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ULC Technologies LLC (Hauppauge, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aalap R. Shah (Princeton, New Jersey); Brendan Reilly (Bethpage, New York) |
| ABSTRACT | A system and method for additive manufacturing are provided. The system for additive manufacturing can include a fabrication robot configured to perform a fabrication process within a pipe, and a support robot configured to support the fabrication robot. The fabrication process may include the fabrication robot depositing a material on the pipe, thus consuming material throughout the fabrication process. The support robot may traverse between an entrance of the pipe and the fabrication robot to obtain additional material and to refill the fabrication robot and the material is consumed. The support robot may further be configured to install and remove one or more tether management rings along bends within the pipe, such that the tether management rings can reduce drag caused by a tether of the fabrication robot. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501726 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/25 (20210101) B22F 10/30 (20210101) B22F 12/57 (20210101) B22F 12/80 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149490 | Mitchell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Mitchell (Oak Ridge, Tennessee); Trevor Aguirre (Oak Ridge, Tennessee); Corson L. Cramer (Oak Ridge, Tennessee); Richard A. Lowden (Oak Ridge, Tennessee) |
| ABSTRACT | A method of fabricating a refractory metal ceramic matrix interpenetrating phase harsh environment capable composite is provided. The method includes forming a reinforcing phase by additive manufacturing and introducing a matrix material to the reinforcing phase. The step of introducing the matrix material may be performed by additive manufacturing or a densification process. The reinforcing phase may be a lattice formed of metal or a ceramic, and the matrix material may be a ceramic or a metal. Alternatively, the reinforcing phase formed by additive manufacturing is a laminate layer, and the matrix material introduced to the reinforcing phase is a laminate layer deposited on the reinforcing phase by additive manufacturing in a plurality of alternating layers. A refractory metal ceramic matrix composite is also disclosed. The refractory metal ceramic matrix composite includes a lattice formed by additive manufacturing, and a matrix material deposited in the lattice. |
| FILED | Tuesday, May 02, 2023 |
| APPL NO | 18/142132 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Original (OR) Class Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 41/0072 (20130101) C04B 41/457 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150183 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gang Chen (Carlisle, Massachusetts); Evelyn N. Wang (Cambridge, Massachusetts); Svetlana Boriskina (Winchester, Massachusetts); Lee A. Weinstein (Somerville, Massachusetts); Sungwoo Yang (Chattanooga, Tennessee); Bikramjit S. Bhatia (Cambridge, Massachusetts); Lin Zhao (Revere, Massachusetts); Elise M. Strobach (Clear Lake, Wisconsin); Thomas A. Cooper (Boston, Massachusetts); David M. Bierman (Cambridge, Massachusetts); Xiaopeng Huang (Mountain View, California); James Loomis (Valparaiso, Florida) |
| ABSTRACT | A silica aerogel having a mean pore size less than 5 nm with a standard deviation of 3 nm. The silica aerogel may have greater than 95% solar-weighted transmittance at a thickness of 8 mm for wavelengths in the range of 250 nm to 2500 nm, and a 400° C. black-body weighted specific extinction coefficient of greater than 8 m2/kg for wavelengths of 1.5 μm to 15 μm. Silica aerogel synthesis methods are described. A solar thermal aerogel receiver (STAR) may include an opaque frame defining an opening, an aerogel layer disposed in the opaque frame, with at least a portion of the aerogel layer being proximate the opening, and a heat transfer fluid pipe in thermal contact with and proximate the aerogel layer. A concentrating solar energy system may include a STAR and at least one reflector to direct sunlight to an opening in the STAR. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508634 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0091 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/14 (20130101) C01B 33/1585 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/64 (20130101) C01P 2006/16 (20130101) C01P 2006/32 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/064 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 10/95 (20180501) F24S 20/20 (20180501) F24S 23/70 (20180501) F24S 70/20 (20180501) F24S 80/56 (20180501) F24S 80/65 (20180501) F24S 2023/872 (20180501) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150520 | Coates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York); University of Pittsburgh - of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Yiye Lu (Ithaca, New York); Tara Y. Meyer (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods for regioselective ring-opening polymerization of unsymmetrical cyclic diester monomers, polymers, which may be made by the methods, and uses of same. Monomers may include cyclic hydroxy-acid dimers, such as, for example, 3-methyl glycolide and the like. Polymerization initiators may include chiral metal alkoxide initiators, such as, for example, (SalBinam)Al-01Pr initiators and the like. Polymers may include polyesters, such as, for example, poly(lactic-co-glycolic acid) (PLGA) and the like, with 90% or greater regioselectivity for alternating ester units (e.g., glycolic unit-lactic unit (G—L) linkages). Polymers may be utilized for substained or targeted drug delivery vehicles, scaffolding for tissue engineering, bioabsorbable sutures, or the like. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 18/546039 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) Original (OR) Class C08G 63/84 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150775 | Melis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastasios Melis (El Cerrito, California); Cinzia Formighieri (Saugus, Massachusetts) |
| ABSTRACT | This invention provides compositions and methods for providing high product yield of transgenes expressed in cyanobacteria and microalgae. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/544275 |
| CURRENT CPC | Peptides C07K 2319/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 15/74 (20130101) Original (OR) Class Enzymes C12Y 402/0302 (20130101) C12Y 402/03051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150803 | OAKLEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Berl OAKLEY (Lawrence, Kansas); Travis J. WILLIAMS (Los Angeles, California); Yi-Ming CHIANG (Los Angeles, California); Clay C. WANG (Los Angeles, California); Yuhao CHEN (Los Angeles, California); Swati BIJLANI (Los Angeles, California); C. Elizabeth OAKLEY (Lawrence, Kansas); Christian Anthony RABOT (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California); UNIVERSITY OF KANSAS (Lawrence, Kansas) |
| INVENTOR(S) | Berl OAKLEY (Lawrence, Kansas); Travis J. WILLIAMS (Los Angeles, California); Yi-Ming CHIANG (Los Angeles, California); Clay C. WANG (Los Angeles, California); Yuhao CHEN (Los Angeles, California); Swati BIJLANI (Los Angeles, California); C. Elizabeth OAKLEY (Lawrence, Kansas); Christian Anthony RABOT (Los Angeles, California) |
| ABSTRACT | A non-human organism for upgrading intermediate oxidation products formed by catalytic degradation of alkanes or polystyrenes is provided. The non-human organism is genetically modified to convert the intermediate oxidation products to secondary metabolites, and in particular to include a positive feedback loop construction in the promotor system. A method includes steps of catalytically degrading alkanes or polystyrene in an oxidizing environment to form intermediate products with one or more catalysts and contacting the intermediate products with the non-human organism such that intermediate oxidation products are converted to secondary metabolites. |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/380447 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/24 (20130101) B01J 31/0244 (20130101) B01J 31/0247 (20130101) B01J 31/2208 (20130101) B01J 2231/70 (20130101) B01J 2531/72 (20130101) B01J 2531/842 (20130101) B01J 2531/845 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1051 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) C12P 17/162 (20130101) Original (OR) Class Enzymes C12Y 204/01183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150817 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Devleena Samanta (Evanston, Illinois); Sasha B. Ebrahimi (DeKalb, Illinois) |
| ABSTRACT | The present disclosure provides a general strategy based on CRISPR and oligonucleotide-detectable marker conjugates that allows sensitive detection of nucleic acid and non-nucleic acid target analytes without stringent temperature requirements. In various aspects, this strategy can be used for rapid and routine detection of viral and bacterial infections, screening of diseases with known biomarkers, and tracking the progression of diseases or response to therapy over time. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/283710 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/16 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) C12Q 1/70 (20130101) C12Q 1/6823 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/922 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150886 | WARD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PATRICK A. WARD (AIKEN, South Carolina); ZACHARY DUCA (AUGUSTA, Georgia); JOHN T. BOBBITT, III (EVANS, Georgia) |
| ABSTRACT | A sputtering apparatus includes a substrate holder assembly configured to support a plurality of elongated substrates relative to a sputtering source. Each elongated substrate of the plurality of elongated substrates extends along a respective substrate axis. The sputtering apparatus also includes a holder drive assembly that is configured to rotate the substrate holder assembly about a holder axis. Each respective substrate axis is oriented non-parallel relative to the holder axis. Further, the sputtering apparatus includes a substrate drive assembly that is configured to individually rotate each elongated substrate about its respective substrate axis. The sputtered material is configured to be deposited onto the plurality of elongated substrates as the substrate holder assembly is being rotated about the holder rotational axis simultaneous with the rotation of each elongated substrate about its respective substrate axis. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/983454 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/505 (20130101) C23C 14/3407 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151472 | IYER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaisree Kannan IYER (Fremont, California); Pratanu Roy (San Ramon, California); Du T. Nguyen (Castro Valley, California); Joshuah K. Stolaroff (Oakland, California) |
| ABSTRACT | The present disclosure relates to a method for forming a transport mechanism for transporting at least one of a gas or a liquid. The method may comprise using a 3D printing operation to form the mechanism with an inlet and an outlet, and controlling the 3D printing operation to create the mechanism as an engineered surface structure formed in a layer-by-layer process. The method may further comprise controlling the 3D printing operation such that the engineered surface structure includes a plurality of cells propagating periodically in three dimensions, with non-intersecting, non-flat, continuously curving wall portions which form two non-intersecting domains, and where the wall portions have openings forming a plurality of flow paths extending in three orthogonal dimensions throughout from the inlet to the outlet, and such that the engineered cellular structure has wall portions having a mean curvature other than zero. |
| FILED | Monday, December 04, 2023 |
| APPL NO | 18/528250 |
| CURRENT CPC | Separation B01D 53/0407 (20130101) B01D 67/002 (20130101) B01D 67/0041 (20130101) B01D 69/02 (20130101) B01D 2253/342 (20130101) Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 23/23 (20220101) B01F 25/4522 (20220101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 4/004 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Come into Direct Contact Without Chemical Interaction F28C 3/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151594 | Dennett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cody A. Dennett (Arlington, Massachusetts); Robert S. Schley (Rigby, Idaho); Yuzhou Wang (Idaho Falls, Idaho); David H. Hurley (Idaho Falls, Idaho); Geoffrey L. Beausoleil (Idaho Falls, Idaho); Daniel J. Murray (Idaho Falls, Idaho); Michael J. Moorehead (Rigby, Idaho) |
| ABSTRACT | Embodiments disclosed herein relate to measuring thermal properties. At least one embodiment includes a method including heating a location of an object with an excitation laser beam, the excitation laser beam being a continuous-wave laser beam modulated by a square-wave modulation waveform. The method may also include measuring temperature at the location over time by measuring changes in one or more reflective properties at the location. Related apparatuses are also disclosed. |
| FILED | Wednesday, October 18, 2023 |
| APPL NO | 18/489706 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/125 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4811 (20130101) G01S 7/4818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151626 | Schloesser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | American Ecotech L.C. (Warren, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Herbert Schloesser (Warren, Rhode Island); Stephen Petrarca (Warren, Rhode Island); Anthony Pacheco (Warren, Rhode Island); Andrew Tolley (Warren, Rhode Island) |
| ABSTRACT | A method for determining airborne concentrations of an ensemble of particulate matter below the size fraction 2.5 μm in aerodynamic diameter (PM2.5). The method is to be composed of a sharp cut PM2.5 cyclone, optical sensor capable of producing scattering coefficients dependent on particle size, temperature and humidity sensors for adapting to changes in the environment, and a processing system for applying logic-based algorithm to convert raw sensor values into PM concentrations. The optical sensor is a dual wavelength integrating nephelometer capable of yielding particle characteristic scattering coefficients at two wavelengths. The particle scattering ratios between two wavelengths are used in conjunction with temperature and humidity in the method's algorithm to reduce particle growth bias and to ultimately yield PM2.5 concentrations. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/502446 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/06 (20130101) Original (OR) Class G01N 2015/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151862 | Pegg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Scintilex, LLC (Alexandria, Virginia) |
| ASSIGNEE(S) | Scintilex, LLC (Alexandria, Virginia) |
| INVENTOR(S) | Ian Louis Pegg (Alexandria, Virginia); Tanja Horn (Lorton, Virginia) |
| ABSTRACT | Fiber reinforced aerogel composites, including a transparent composite material that contains an aerogel and fibers embedded into the aerogel and/or bonded to one or more surfaces of the aerogel, and composites that contain an aerogel tile and an assemblage of fibers embedded into the aerogel tile or bonded to the aerogel tile that are useful as Cherenkov radiators for the detection and identification of subatomic particles. Also, methods of making and using the composites. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/389907 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 23/0006 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/76 (20130101) C04B 35/82 (20130101) C04B 38/0045 (20130101) C04B 2111/805 (20130101) Measurement of Nuclear or X-radiation G01T 1/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153651 | Gates |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Gates (Princeton, New Jersey) |
| ABSTRACT | Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution. |
| FILED | Thursday, January 18, 2024 |
| APPL NO | 18/415840 |
| CURRENT CPC | Fusion Reactors G21B 1/055 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153659 | Ocampo Giraldo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis A. Ocampo Giraldo (Idaho Falls, Idaho); David L. Chichester (Idaho Falls, Idaho); James T. Johnson (Rigby, Idaho); Jay D. Hix (Idaho Falls, Idaho); Scott J. Thompson (Ammon, Idaho); Scott M. Watson (Idaho Falls, Idaho) |
| ABSTRACT | A radiation monitoring system includes an optical fiber. The system further includes a scintillating fiber operatively coupled to a first end of the optical fiber at a first end of the scintillating fiber. The system also includes a damage detection device configured to detect damage to at least one of the optical fiber and the scintillating fiber. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501888 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/201 (20130101) G01T 1/2002 (20130101) Optical Elements, Systems, or Apparatus G02B 6/4296 (20130101) G02B 2006/4297 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 5/002 (20130101) G21F 5/125 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153862 | LU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guo-Quan LU (Blacksburg, Virginia); Chao DING (Blacksburg, Virginia) |
| ABSTRACT | Planar, double-side cooled half-bridge power modules using sintered-silver interposers and all sintered-silver joints are described. Thermo-mechanical simulations showed that use of the sintered-silver interposers reduce the thermo-mechanical stresses at vulnerable interfaces as compared to using solid copper interposers. The porous sintered-silver interposers are also easily deformable under a low load, which improves the yield of module interconnections in the presence of imperfections caused by variations in die thickness, interposer height, and substrate distortion. Results on the electrical performance of the modules validate the fabrication approach for the modules, for making high power-density converters with reliable operations at high junction temperatures. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 18/549443 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/5286 (20130101) H01L 23/49822 (20130101) H01L 23/49844 (20130101) H01L 23/49861 (20130101) Original (OR) Class H01L 23/49894 (20130101) H01L 24/27 (20130101) H01L 24/32 (20130101) H01L 24/48 (20130101) H01L 29/1608 (20130101) H01L 2224/27848 (20130101) H01L 2224/32245 (20130101) H01L 2224/48245 (20130101) H01L 2924/351 (20130101) H01L 2924/37001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240154499 | Tschida et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wright Electric Inc. (Ballston Spa, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Colin Tschida (Ballston Spa, New York); Piotr Kurowski (Ballston Spa, New York); Earl Fairall (Ballston Spa, New York); Patrick Biel (Ballston Spa, New York) |
| ABSTRACT | An aircraft has an electric motor to generate thrust and a power electronic module to provide power to the electric motor. The power electronic (PE) module has an output power to fluidly couple the electric motor and the PE module. The aircraft has an alternating current (AC) lead to electrically couple the PE module and the electric motor by way of the output port. The AC lead is submerged within the output port by a liquid coolant. The aircraft also has a cooling system including a heat extractor. The cooling system passes the liquid coolant through the PE module including the output port, then through the electric motor, and then through the heat extractor. |
| FILED | Friday, August 18, 2023 |
| APPL NO | 18/235715 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/08 (20130101) Dynamo-electric Machines H02K 9/19 (20130101) Original (OR) Class H02K 11/33 (20160101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240154794 | RAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nageswara S. V. RAO (Oak Ridge, Tennessee); Muneer ALSHOWKAN (Oak Ridge, Tennessee); Anees AL-NAJJAR (Knoxville, Tennessee); Susan E. HICKS (Kingston, Tennessee); Philip G. EVANS (Clinton, Tennessee); Joseph M. LUKENS (Knoxville, Tennessee); Nicholas A. PETERS (Knoxville, Tennessee) |
| ABSTRACT | A framework for authenticating firewall and encryption devices (FEDs) as endpoints of a secure tunnel using quantum-based secrets keys are provided. The secure tunnel is between two network sites. A quantum key distribution (QKD) subsystem is collocated, in part, with a first network site in another part, with a second network site. The QKD subsystem generates and shares at least one quantum-based secret key with respective key hosts in the first network site and second network site. Each FED obtains the same quantum-based secret key from the respective key host and authenticate each other as endpoints of the secure tunnel to be established between the first network site and the second network site through the public network. The authentication may be repeated. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501512 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0852 (20130101) Original (OR) Class H04L 63/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240148800 | Aroian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raffi Van Aroian (Worcester, Massachusetts); Gary R. Ostroff (Worcester, Massachusetts) |
| ABSTRACT | Compositions and methods for treating or reducing the severity of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a composition comprising isolated native, bioactive nematicidal crystals formed from a single type of nematicidal crystal protein. The isolated native, bioactive nematicidal crystals are substantially free of any bacterial spores or host bacterial proteins, other than nematicidal crystal protein in the form of a crystal. Methods for making isolated native, bioactive nematicidal crystals are also described. The crystal proteins may be full length, truncated, variant, or sub-variant Cry proteins. Examples of crystal proteins include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485796 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/48 (20130101) A61K 35/741 (20130101) Original (OR) Class A61K 38/164 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149189 | Arthur et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fremonta Corporation (San Jose, California); United States as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Terrance Arthur (Hastings, Nebraska); Tommy Wheeler (Clay Center, Nebraska); Eric Child Wilhelmsen (Milpitas, California); Florence Q. Wu (Milpitas, California); Yongqing Huang (San Jose, California); Wei Wu (Fremont, California) |
| ABSTRACT | Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, a method may include providing at least one aggregating sampler at one or more sampling locations, and sampling a production lot of produce or other food items such as meat using the at least one aggregating sampler to create one or more samples that makes up a microbial sampling. Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, an apparatus, such as a microbial aggregating sampler, may include a covering having a microbial sampling material with a pocket formed in the covering to receive an appendage or a tool for handling of the covering. |
| FILED | Friday, January 19, 2024 |
| APPL NO | 18/418100 |
| CURRENT CPC | Separation B01D 21/262 (20130101) Original (OR) Class B01D 61/025 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6888 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/02 (20130101) G01N 1/4077 (20130101) G01N 33/02 (20130101) G01N 2001/4088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149266 | Youngbull et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nucleic Sensing Systems, LLC (Saint Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cody Youngbull (Arlington, Virginia); Andrew Hatch (West Jordan, Utah) |
| ABSTRACT | Systems, methods, and apparatuses for the detection of changes within a fluid composition while it flows in a channel. Microfluidics devices can include a detector that may include a tunable offset mechanism. The detectors can work in conjunction with an energy source that passes energy through the flow channel and into the detectors. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500421 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) Original (OR) Class B01L 2300/023 (20130101) B01L 2300/0654 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149269 | Youngbull |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nucleic Sensing Systems, LLC (Saint Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cody Youngbull (Arlington, Virginia) |
| ABSTRACT | A thermal manifold structured and configured to maintain a temperature profile required to perform a reverse transcription reaction within a flow channel having a liquid contained therein. In some embodiments, the reverse transcription reaction may occur while the liquid is in a laminar flow regime within the flow channel. The thermal manifold may include an integral flow channel, or a flow channel with a Teflon tube contained therein. Additionally, the placement of the thermal manifold may vary within a continuous-flow emulsion droplet reactor system. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500425 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 7/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150705 | Nitin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Nitin Nitin (Davis, California); Rewa Rai (Davis, California); Marluci Palazzolli da Silva Padilha (Campinas, Brazil) |
| ABSTRACT | Vacuum infusion of plant extracts in live probiotic cells significantly enhances the viability of probiotics during in vitro gastrointestinal digestion with the retention of their metabolic and antagonistic activities. In-vivo results validate the significantly enhanced persistence and mucoadhesion of probiotic cells with infused plant extracts. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/542860 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/745 (20130101) A61K 35/747 (20130101) A61K 36/61 (20130101) A61K 36/77 (20130101) A61K 36/87 (20130101) A61K 2236/333 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/04 (20130101) Original (OR) Class C12N 1/205 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/23 (20210501) C12R 2001/25 (20210501) C12R 2001/245 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150785 | Lundquist et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Peter K. Lundquist (Okermos, Michigan); Sheng Ying (Lansing, Michigan); Wolf Scheible (Ardmore, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter K. Lundquist (Okermos, Michigan); Sheng Ying (Lansing, Michigan); Wolf Scheible (Ardmore, Oklahoma) |
| ABSTRACT | Described herein are expression cassettes, plant cells, plant seeds, plants, and methods useful for delaying flowering, increasing biomass accumulation, and increasing drought tolerance in plants. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465840 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/827 (20130101) C12N 15/8273 (20130101) Original (OR) Class C12N 2830/002 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240148688 | JAMIESON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Catriona JAMIESON (San Diego, California); Leslie CREWS ROBERTSON (San Diego, California); Michael BURKART (San Diego, California); Larisa BALAIAN (San Diego, California); Phoebe MONDALA (San Diego, California); Cayla MASON (San Diego, California); Raymond H. DIEP (San Diego, California); James LACLAIR (San Diego, California); Thomas WHISENANT (San Diego, California); Warren C. CHAN (San Diego, California); Inge VAN DER WERF (San Diego, California); Peggy WENTWORTH (San Diego, California); Wenxue MA (San Diego, California) |
| ABSTRACT | In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 18/275388 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) Original (OR) Class A61K 31/506 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150044 | VANCE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LEONARD VANCE (Tucson, Arizona); JOSE MARIA FERNANDEZ MORENO (Tucson, Arizona); JEKAN THANGAVELAUTHAM (Tucson, Arizona) |
| ABSTRACT | The present disclosure provides a satellite system with orbital debris avoidance. In one embodiment, the satellite system includes debris sensor circuitry to scan orbital debris items in an orbital debris field; and sensor controller circuitry to determine a search window within the orbital debris field based on, at least, uncertainties associated with a velocity of the satellite (Vsatellite) and uncertainties associated with a velocity of at least one debris item (Vdebris), the sensor controller circuitry also to control the debris sensor circuitry to detect the at least one debris item within the search window. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 18/281474 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/68 (20130101) B64G 1/242 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240150256 | Bognar |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John A. Bognar (Belgrade, Montana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Bognar (Belgrade, Montana) |
| ABSTRACT | Thermite mixtures shaped or cast into a desired solid form and having sufficient structural integrity to withstand rough handling and challenging operating conditions, and methods of making such solid forms, are provided. When reacted, the thermite mixtures advantageously produce little or no offgas. The solid thermite forms may further include other materials that confer advantageous physical or chemical properties before, during, or after reaction of the thermite mixture. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/543210 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 33/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151358 | Minas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Constantinos Minas (Slingerlands, New York); Ernst Wolfgang Stautner (Niskayuna, New York) |
| ABSTRACT | Example integrated cryogenic hydrogen tank systems and methods for operating the same are disclosed herein. An example system comprises a first cryogenic tank coupled to a second cryogenic tank via a liquid hydrogen (LH2) transfer flowline and a gaseous hydrogen (GH2) transfer flowline, the LH2 transfer flowline and the GH2 transfer flowline to maintain a fuel level and a vapor pressure across the system, the fuel level corresponding to a cryogenic liquid; an inlet port connected to one of the first cryogenic tank or the second cryogenic tank; an LH2 extraction flowline connected to at least one of the first or second cryogenic tanks to supply the cryogenic liquid to a fuel management system; and a pressure safety system coupled to at least one of the first or second cryogenic tanks via a GH2 extraction flowline. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/982114 |
| CURRENT CPC | Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 5/04 (20130101) Original (OR) Class F17C 2203/066 (20130101) F17C 2203/0391 (20130101) F17C 2203/0629 (20130101) F17C 2205/0138 (20130101) F17C 2205/0332 (20130101) F17C 2205/0355 (20130101) F17C 2221/012 (20130101) F17C 2223/0161 (20130101) F17C 2227/0135 (20130101) F17C 2227/0302 (20130101) F17C 2250/03 (20130101) F17C 2250/043 (20130101) F17C 2270/0189 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151902 | Bhethanabotla et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venkat Rama Bhethanabotla (Tampa, Florida); Thomas M. Weller (Corvallis, Oregon); Roger Brandon Tipton (Wesley Chapel, Florida); John Townsend Bentley (Tampa, Florida); Eduardo Antonio Rojas (Port Orange, Florida) |
| ABSTRACT | A novel polymer optical waveguide and method of manufacturing is presented herein. A digitally manufactured process is described which utilizes a micro-dispensed UV optical adhesive as the contour guiding cladding, a fused deposition modeling technology for creating a core, and a subtractive laser process to finish the two ends of the optical interconnect. The optical waveguide can be printed directly on a circuit board in some embodiments. Alternatively, using a slightly modified process including a step to bond the optical fiber to the substrate, the optical interconnect can be manufactured on a flexible substrate. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 17/982907 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2101/12 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Optical Elements, Systems, or Apparatus G02B 6/138 (20130101) G02B 6/1221 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240154626 | Wesel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Richard D. Wesel (Manhattan Beach, California); Linfang Wang (Los Angeles, California); Sean Chen (Los Angeles, California); Dariush Divsalar (Pacific Palisades, California); Jonathan Nguyen (Los Angeles, California) |
| ABSTRACT | Neural Normalized MinSum (N-NMS) decoding for improving frame error rate (FER) performance on linear block codes over conventional normalized MinSum (NMS). Dynamic multiplicative weights are assigned to each check-to-variable message in each iteration to efficiently provide training parameters of N-NMS that support N-NMS for longer block lengths. Embodiment are described for neural two-dimensional normalized MinSum (N-2D-NMS) decoders requiring fewer training parameters. The N-2D-NMS approaches for example use the same weight for edges with the same check and/or variable node degree. Simulation results indicate that that this LDPC decoding performs similarly to previous techniques while substantially reducing the amount of training necessary. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/240162 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 13/1111 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240149266 | Youngbull et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nucleic Sensing Systems, LLC (Saint Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cody Youngbull (Arlington, Virginia); Andrew Hatch (West Jordan, Utah) |
| ABSTRACT | Systems, methods, and apparatuses for the detection of changes within a fluid composition while it flows in a channel. Microfluidics devices can include a detector that may include a tunable offset mechanism. The detectors can work in conjunction with an energy source that passes energy through the flow channel and into the detectors. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500421 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) Original (OR) Class B01L 2300/023 (20130101) B01L 2300/0654 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240149269 | Youngbull |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nucleic Sensing Systems, LLC (Saint Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cody Youngbull (Arlington, Virginia) |
| ABSTRACT | A thermal manifold structured and configured to maintain a temperature profile required to perform a reverse transcription reaction within a flow channel having a liquid contained therein. In some embodiments, the reverse transcription reaction may occur while the liquid is in a laminar flow regime within the flow channel. The thermal manifold may include an integral flow channel, or a flow channel with a Teflon tube contained therein. Additionally, the placement of the thermal manifold may vary within a continuous-flow emulsion droplet reactor system. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500425 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 7/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151624 | Murphy |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Commerce (Silver Spring, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel M. Murphy (Boulder, Colorado) |
| ABSTRACT | Embodiments in accordance with the present invention relate to an apparatus for optical characterization of aerosol particles, including a laser source; a beam splitter configured to split the laser into two orthogonally polarized optical beams, wherein one component of the orthogonally polarized optical beam is deflected from the second component of the polarized optical beam at a predetermined angle; a cylindrical lens for collecting the two orthogonally polarized optical beams and focusing each of the optical beams to an interrogation region; an inlet positioned to deliver the sample gas including particles to the interrogation region as a single particle gas stream through the interrogation region; an ellipsoidal mirror positioned at a non-perpendicular angle adjacent to paths traversed by the polarized optical beams to reflect scattered optical beams from the particles traversing through the interrogation region; and a photodetector for measuring the scattered optical beams reflected by the mirror. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/503223 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0211 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240151667 | Labanowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sonora Magnetics, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominic Labanowski (Berkeley, California); Sayeef Salahuddin (Walnut Creek, California) |
| ABSTRACT | A system and method for an acoustically driven ferromagnetic resonance (ADFMR) based sensor including: a power source, that provides an electrical signal to power the system; and an ADFMR circuit, sensitive to electromagnetic fields, wherein the ADFMR circuit comprises an ADFMR device. The system functions to detect and measure external electromagnetic (EM) fields by measuring a perturbation of the electrical signal through the ADFMR circuit due to the EM fields. |
| FILED | Monday, July 17, 2023 |
| APPL NO | 18/222543 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/10 (20130101) Original (OR) Class Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 5/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240151862 | Pegg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Scintilex, LLC (Alexandria, Virginia) |
| ASSIGNEE(S) | Scintilex, LLC (Alexandria, Virginia) |
| INVENTOR(S) | Ian Louis Pegg (Alexandria, Virginia); Tanja Horn (Lorton, Virginia) |
| ABSTRACT | Fiber reinforced aerogel composites, including a transparent composite material that contains an aerogel and fibers embedded into the aerogel and/or bonded to one or more surfaces of the aerogel, and composites that contain an aerogel tile and an assemblage of fibers embedded into the aerogel tile or bonded to the aerogel tile that are useful as Cherenkov radiators for the detection and identification of subatomic particles. Also, methods of making and using the composites. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/389907 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 23/0006 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/76 (20130101) C04B 35/82 (20130101) C04B 38/0045 (20130101) C04B 2111/805 (20130101) Measurement of Nuclear or X-radiation G01T 1/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240153229 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); Mark A. BUCKLER (Wenham, Massachusetts); Vladimir VALTCHINOV (Boston, Massachusetts); David S. PAIK (Moon Bay, California) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Monday, May 01, 2023 |
| APPL NO | 18/309903 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) Original (OR) Class G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240148658 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daeyeon LEE (Wynnewood, Pennsylvania); Yun Kee JO (Philadelphia, Pennsylvania); Robert Leon MAUCK (Philadelphia, Pennsylvania); George R. DODGE (Philadelphia, Pennsylvania) |
| ABSTRACT | A composition, comprising: a plurality of mechanically-activated microcapsules; a mechanically-activated microcapsule defining a shell and an exterior surface; and the mechanically-activated microcapsule comprising one or more adhesion groups disposed Non the exterior surface of the mechanically-activated microcapsule, the one or more adhesion groups being configured to effect a covalent interaction, a non-covalent interaction, or both between the one or more adhesion groups and a matrix material, the covalent interaction, the non-covalent interaction, or both adhering the mechanically-activated microcapsule to the matrix material. Also provided are related methods and related articles. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/552711 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) A61K 9/5031 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240148984 | McCarty |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan McCarty (Los Angeles, California) |
| ABSTRACT | A sheath assembly for use with an elongated needle may include an elongated body portion configured to slidably receive the elongated needle therein, wherein the elongated sheath includes a top surface, a bottom surface, a proximal end, a distal end, and at least one joint portion formed adjacent or proximate the distal end of the sheath. Preferably, at least one joint portion is disposed adjacent or proximate the distal end of the sheath so that a bend in the elongated sheath at least one joint portion produces a corresponding bend in the needle. As such, the needle remains in the sterile environment of the sheath during the bending process, the sheath protecting the physician from needle pricks. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/502774 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/3286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20240150438 | WESTENDORF et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn WESTENDORF (Vancouver, Canada); Stefanie ZENTELIS (Vancouver, Canada); Krithika MUTHURAMAN (Toronto, Canada); Kevin JEPSON (Vancouver, Canada); Ester FALCONER (North Vancouver, Canada); John MASCOLA (Bethesda, Maryland); Barney GRAHAM (Bethesda, Maryland); Kizzmekia CORBETT (Bethesda, Maryland); Julie LEDGERWOOD (Bethesda, Maryland); Lingshu WANG (Bethesda, Maryland); Olubukola ABIONA (Bethesda, Maryland); Wei SHI (Bethesda, Maryland); Wing-pui KONG (Bethesda, Maryland); Yi ZHANG (Bethesda, Maryland); Bryan Edward JONES (San Diego, California); Denisa FOSTER (San Diego, California); Julian DAVIES (La Jolla, California); Qing CHAI (San Diego, California); Christopher Carl FRYE (Bargersville, Indiana); Ganapathy GOPALRATHNAM (Fishers, Indiana); Jörg HENDLE (San Diego, California); John Michael SAUDER (Carlsbad, California); Jeffrey Streetman BOYLES (Indianapolis, Indiana); Anna PUSTILNIK (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/194105 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 47/02 (20130101) A61K 47/26 (20130101) A61K 47/68 (20170801) A61K 47/183 (20130101) A61K 47/6801 (20170801) A61K 47/6803 (20170801) A61K 47/6841 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240150440 | ROBERTS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lumen Bioscience, Inc. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Michael ROBERTS (Seattle, Washington); Benjamin JESTER (Seattle, Washington); Mesfin Mulugeta GEWE (Bothell, Washington); Nhi Yen KHUONG (Kenmore, Washington) |
| ABSTRACT | The present disclosure relates to single domain antibodies (“VHHs”) against SARS-CoV-2, as well as to polypeptides comprising one or more of such VHHs. The disclosure also relates to nucleic acids encoding such VHHs and polypeptides; to methods of preparing such VHHs and polypeptides; to host cells expressing or capable of expressing such VHHs or polypeptides; to compositions comprising such VHHs, polypeptides, nucleic acids or host cells; and to uses of such VHHs, such polypeptides, such nucleic acids, such host cells or such compositions, in particular for prophylactic, therapeutic or diagnostic purposes. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 18/268844 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/517 (20130101) A61K 2039/543 (20130101) Peptides C07K 14/7056 (20130101) C07K 16/1003 (20230801) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, May 09, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240509.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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