FedInvent™ Patent Applications
Application Details for Thursday, May 16, 2024
This page was updated on Tuesday, June 18, 2024 at 02:21 PM GMT
Department of Health and Human Services (HHS)
| US 20240156049 | CHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wuhan university of science and technology (Wuhan, China PRC); Hubei Provincial Center for Disease Control and Prevention (Wuhan, China PRC) |
| ASSIGNEE(S) | Wuhan university of science and technology (Wuhan, China PRC); Hubei Provincial Center for Disease Control and Prevention (Wuhan, China PRC) |
| INVENTOR(S) | Jing CHENG (Wuhan, China PRC); Jianbo ZHAN (Wuhan, China PRC); Dan LI (Wuhan, China PRC); Xiang ZHONG (Wuhan, China PRC); Ling HU (Wuhan, China PRC); Tao HUANG (Wuhan, China PRC); Guiping WANG (Wuhan, China PRC); Lin-Wanyue CHEN (Wuhan, China PRC); Yutong ZHANG (Wuhan, China PRC) |
| ABSTRACT | The present invention belongs to animal experiments field, disclosed a single factor modeling-constraint method and device for mice chronic fatigue syndrome, the modeling-constraint method is specifically using mineral water bottle to restraint mice; the mineral water bottle is divided into upper, middle and lower parts; the body of mineral water bottle is uniformly drilled for mice to breathe; the inner of the mineral water bottle is blocked by a cardboard to reduce the move space of mice; cover the mice through the divided bottle; one end of the opening is tightly attach to the wall, the other end is tightly attach to the mice feeding box, and keeping 30 minutes to restraint. The present invention utilizes mineral water bottle to make three simple restraint tube, not only saves the costs of experiment, but also turns waste into treasure, which is a simple operation, and increases the possibility of the experiment. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504768 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 1/0613 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156083 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu Shrike Zhang (Boston, Massachusetts); Zeyu Luo (Boston, Massachusetts) |
| ABSTRACT | A method of making a 3D-printed biomaterial is described. The method includes depositing a hydrogel comprising cells and a cryoprotectant from a 3D printer onto a freezing plate to form a frozen hydrogel filament; depositing additional hydrogel comprising cells and a cryoprotectant from a 3D printer in contact with a previously placed frozen hydrogel filament to form a 3D-printed biomaterial comprising a plurality of frozen hydrogel filaments; and removing the 3D-printed biomaterial from the freezing plate. 3D-printed biomaterials made by the method are also described. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506291 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) A01N 1/0284 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) C12N 5/0656 (20130101) C12N 5/0658 (20130101) C12N 5/0662 (20130101) C12N 2513/00 (20130101) C12N 2533/54 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156355 | O'Brien et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christine O'Brien (St. Louis, Missouri); Leonid Shmuylovich (St. Louis, Missouri); Samuel Achilefu (St. Louis, Missouri); Francesca Bonetta-Misteli (St. Louis, Missouri) |
| ABSTRACT | Systems, devices, and methods for monitoring for postpartum hemorrhage (PPH) in a subject are disclosed. The disclosed system includes a laser speckle flow index sensor to monitor peripheral perfusion of the subject, and a multispectral Hb sensor to monitor intravascular hemoglobin concentration of the subject. The LSFI (laser speckle flow index) sensor uses laser speckle imaging of peripheral skin and muscle tissues to monitor peripheral perfusion. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 18/550591 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/0261 (20130101) A61B 5/02042 (20130101) Original (OR) Class A61B 5/6802 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156369 | Kumar et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivek Kumar (Bar Harbor, Maine); Janine Wotton (Bar Harbor, Maine); Jacqui White (Bar Harbor, Maine) |
| ABSTRACT | Systems and methods described herein provide techniques for automated phenotyping. The systems and methods, in some embodiments, processes video data, identifies body parts, extracts features on a frame-level, and determines subject behavior captured in the video data. The systems and methods may use one or more machine learning models. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 18/007429 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/1105 (20130101) Original (OR) Class A61B 5/1114 (20130101) A61B 5/1128 (20130101) A61B 5/4824 (20130101) A61B 5/7267 (20130101) A61B 2503/40 (20130101) A61B 2503/42 (20130101) Image Data Processing or Generation, in General G06T 7/74 (20170101) G06T 2207/10016 (20130101) Image or Video Recognition or Understanding G06V 10/751 (20220101) G06V 20/41 (20220101) G06V 20/70 (20220101) G06V 40/10 (20220101) G06V 40/20 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156391 | Barbosa et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Alves Neiva Barbosa (Stanford, California); Vivek Buch (Stanford, California); Sandra Gattas (Stanford, California); Casey Halpern (Stanford, California); Yuhao Huang (Stanford, California); Rajat Shivacharan (Stanford, California) |
| ABSTRACT | Provided herein, inter alia, are methods for detecting brain structure modulations associated with impaired inhibitory control disorders (ICD). The methods are useful for treating of a variety of neurological and psychiatric conditions, and can include neurostimulation to specific regions of the brain. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 18/552570 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/374 (20210101) Original (OR) Class A61B 5/4836 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156399 | IACOVIELLO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine of Mount Sinai (New York, New York) |
| ASSIGNEE(S) | Icahn School of Medicine of Mount Sinai (New York, New York) |
| INVENTOR(S) | Brian IACOVIELLO (New York, New York); Dennis CHARNEY (New York, New York) |
| ABSTRACT | Systems and methods for treating a subject with a psychiatric disorder are provided in winch a therapy session is conducted. In the therapy session, each respective expression image in a plurality of expression images is sequentially displayed. Each expression image is independently associated with an expression. The successive display of images is construed as a tiled series of expression image subsets, each consisting of N expression images. Upon completion of the display of each respective subset, the user is challenged as to whether the first and the last images in the respective subset exhibit the same emotion. A score is determined for the respective subset based on whether the subject learned to respond correctly. The number of images in each subset is adjusted to a new number based on these scores. A treatment regimen is prescribed to the subject for the psychiatric disorder based at least in part on the scores. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/424221 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/00 (20130101) A61B 5/165 (20130101) A61B 5/167 (20130101) A61B 5/4076 (20130101) A61B 5/4836 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/70 (20180101) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156403 | Whitfield-Gabrieli et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan Whitfield-Gabrieli (Cambridge, Massachusetts); Clemens Bauer (Roslindale, Massachusetts); Jiahe Zhang (Boston, Massachusetts) |
| ABSTRACT | A neurofeedback method and associated system for modulating brain activity includes functionally locating at least two brain networks in an adolescent subject which are associated with affective disorder symptoms during adolescence. Signals are recorded from each of the brain networks while the subject is performing a mediation task. An activity metric is determined based on a difference derived from the recorded signals, wherein changes in the activity metric over time are indicative of changes in relative activity level of the brain networks. Neurofeedback is provided by delivering a representation of the activity metric to the subject during the recording, thereby modulating brain activity in the subject. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/502948 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/486 (20130101) Original (OR) Class A61B 5/742 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 21/02 (20130101) A61M 2230/10 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156467 | Maris et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| INVENTOR(S) | Nick T. Maris (Germantown, Wisconsin); James S. Miller (Germantown, Wisconsin); Reza Shaker (Brookfield, Wisconsin); Timothy Bachman (St. Paul, Minnesota); Nathan Schlueter (St. Paul, Minnesota); Eugene Paul Maloney (St. Paul, Minnesota); Eric David North (St. Paul, Minnesota); Paul Raine (St. Paul, Minnesota); Peter Alex (Germantown, Wisconsin) |
| ABSTRACT | A compression device is used to increase intra-luminal pressure within the upper esophageal sphincter of a patient in order relieve an impact of an abnormal or defective upper esophageal sphincter anatomy, physiology, or functionality. In one implementation, the compression device is used in conjunction with an external pressure sensing device to determine the external pressure that is to be applied to the cricoid for a specific patient. The compression device can be a means for the management and/or treatment of abnormal upper esophageal sphincter functionality, or a means for strengthening an esophageal sphincter of a subject, or a means for curing esophageal reflux disease of a subject, or a means for improving vocal function in a subject, or a means for managing lung aspiration, or a means for applying cricoid pressure during anesthesia intubation, or a means for stabilizing body structures such as during medical imaging or radiation treatment. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/514562 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/021 (20130101) A61B 5/7278 (20130101) A61B 17/135 (20130101) Original (OR) Class A61B 17/1325 (20130101) A61B 17/1327 (20130101) A61B 2017/00827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156737 | Kovarova et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martina Kovarova (Chapel Hill, North Carolina); Soumya Rahima Benhabbour (Chapel Hill, North Carolina); J. Victor Garcia-Martinez (Durham, North Carolina); Panita Maturavongsadit (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed herein are polymeric implants and controlled release drug delivery systems to provide high drug loading and long-acting drug release. Provided herein are methods for making the same. Methods of administering pharmacologically active agents via the disclosed polymeric implants and controlled release drug delivery systems are also provided. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/391998 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/204 (20130101) Original (OR) Class A61K 9/2095 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156743 | Scott et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Evan A. Scott (Evanston, Illinois); Fanfan Du (Evanston, Illinois); Baofu Qiao (Evanston, Illinois); Monica Olvera de la Cruz (Evanston, Illinois) |
| ABSTRACT | The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472901 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) A61K 9/5146 (20130101) Original (OR) Class A61K 9/5192 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156764 | Gerson |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
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| INVENTOR(S) | Stanton Gerson (Hunting Valley, Ohio) |
| ABSTRACT | A method of treating cancer in a subject in need thereof includes administering to the subject an agent that inhibits uracil-DNA glycosylase wherein the agent binds to UDG such that the UDG is maintained in a destabilized, open precatalytic glycosylase conformation that prevents active site closing for functional DNA binding and nuclease flipping needed to excise damaged bases binding in DNA. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176877 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/194 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156765 | JABLONSKI |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (MEMPHIS, Tennessee) |
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| INVENTOR(S) | Monica M. JABLONSKI (Memphis, Tennessee) |
| ABSTRACT | This invention is directed to a method of preventing ocular neurodegeneration in a subject in need thereof. |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/420262 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 9/113 (20130101) A61K 31/197 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156779 | Sutkeviciute et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Ieva Sutkeviciute (Pittsburgh, Pennsylvania); Jean-Pierre Vilardaga (Pittsburgh, Pennsylvania); Jiyoung Lee (Wexford, Pennsylvania); Ivet Bahar (Wexford, Pennsylvania); Burak Kaynak (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are methods for treating hyperparathyroidism, osteoporosis, or cancer cachexia, or inhibiting abnormally increased white adipose tissue browning, or decreasing the risk of a kidney stone in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a negative allosteric modulator of parathyroid hormone (PTH) type 1 receptor (PTHR) signaling. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 18/277765 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/401 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156782 | TYAVANAGIMATT et al. |
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| FUNDED BY |
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| APPLICANT(S) | Siga Technologies, Inc. (Corvallis, Oregon) |
| ASSIGNEE(S) | Siga Technologies, Inc. (Corvallis, Oregon) |
| INVENTOR(S) | Shanthakumar R. TYAVANAGIMATT (Sammamish, Washington); Melialani A.C.L.S. ANDERSON (Corvallis, Oregon); William C. WEIMERS (Corvallis, Oregon); Dylan NELSON (Corvallis, Oregon); Tove' C. BOLKEN (Keizer, Oregon); Dennis E. HRUBY (Albany, Oregon); Michael H. O'NEILL (Painesville, Ohio); Gary SWEETAPPLE (Madison, Ohio); Kelley A. McCLOUGHAN (South Haven, Michigan) |
| ABSTRACT | Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545961 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1652 (20130101) A61K 9/4866 (20130101) A61K 31/404 (20130101) Original (OR) Class A61K 39/275 (20130101) Heterocyclic Compounds C07D 209/70 (20130101) C07D 209/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156783 | Mohan |
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| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | The Curators of the University of Missouri (Columbia, Missouri); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Rajiv R. Mohan (Columbia, Missouri) |
| ABSTRACT | Provided herein are compositions suitable for treating chemically induced eye damage comprising (a) a nonsteroidal anti-inflammatory drug (NSAID), (b) a histone deacetylase (HDAC) inhibitor and (c) an angiotensin converting enzyme (ACE) inhibitor and, optionally, (d) a water-soluble vitamin. Methods of using provided compositions to treat ocular toxicity and corneal damage following exposure to chemical agents (e.g., mustard gas) are also provided. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390829 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/167 (20130101) A61K 31/375 (20130101) A61K 31/401 (20130101) A61K 31/407 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156790 | STOCKWELL et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent R. STOCKWELL (New York, New York); Arie ZASK (New York, New York); Hui TAN (New York, New York); Jacob D. DANIELS (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and one or more compounds according to the present disclosure. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, methods for treating or ameliorating the effects of a neurodegenerative disease, methods for alleviating side effects in a subject undergoing radiotherapy and/or immunotherapy, and methods for treating or ameliorating the effects of an infection associated with ferroptosis in a subject. |
| FILED | Friday, November 24, 2023 |
| APPL NO | 18/518731 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/166 (20130101) A61K 31/245 (20130101) A61K 31/421 (20130101) A61K 31/4245 (20130101) Original (OR) Class A61K 31/4439 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) A61P 39/06 (20180101) Acyclic or Carbocyclic Compounds C07C 229/60 (20130101) C07C 233/65 (20130101) Heterocyclic Compounds C07D 213/74 (20130101) C07D 213/80 (20130101) C07D 263/32 (20130101) C07D 271/10 (20130101) C07D 295/13 (20130101) C07D 413/04 (20130101) C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156816 | Shalek et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander K. Shalek (Cambridge, Massachusetts); Peter Winter (Cambridge, Massachusetts); David Weinstock (Boston, Massachusetts); Mark Murakami (Boston, Massachusetts); Scott Manalis (Cambridge, Massachusetts); Andrew Navia (Cambridge, Massachusetts); Jennyfer Galvez-Reyes (Cambridge, Massachusetts) |
| ABSTRACT | Described in exemplary embodiments herein are methods, compositions, and kits for diagnosing, prognosing, monitoring, treating and/or preventing a hemopoietic malignancy and/or relapse thereof in a subject. In some embodiments, the methods can include determining an average cellular mass of cells in a sample from the subject and/or detecting one or more molecular signatures in one or more of the cells. In some embodiments, treatment includes administering one or more BCR-ABL tyrosine kinase inhibitors or a pharmaceutical formulation thereof, one or more pre-BCR signaling pathway inhibitors or a pharmaceutical formulation thereof, one or more p38 MAPK inhibitors or a pharmaceutical formulation thereof; or any combination thereof. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541680 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/403 (20130101) A61K 31/427 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/5383 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 16/2887 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156828 | VERKMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan S. VERKMAN (San Francisco, California); Marc H. LEVIN (San Francisco, California) |
| ABSTRACT | The disclosure provides, inter alia, topical pharmaceutical compositions comprising active agents, methods for increasing tear production using the topical pharmaceutical compositions, and methods for treating dry eye disorders using the topical pharmaceutical compositions. |
| FILED | Monday, October 30, 2023 |
| APPL NO | 18/497962 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/53 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156846 | Chang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona); THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rui Chang (Tucson, Arizona); Patrick T. Ronaldson (Tucson, Arizona); Qianying He (Tucson, Arizona); Wassim ELYAMAN (New York, New York); Elizabeth BRADSHAW (New York, New York); Kuixi ZHU (Tucson, Arizona) |
| ABSTRACT | This invention relates generally to neurodegenerative diseases and conditions (e.g., Alzheimer's disease) characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative diseases and conditions with pharmaceutical compositions capable of protecting neurons from cell death and unregulated microglia phagocytic activity. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/113981 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/26 (20130101) A61K 31/357 (20130101) A61K 31/404 (20130101) A61K 31/4409 (20130101) A61K 31/5375 (20130101) A61K 31/7028 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156853 | CHEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qian CHEN (Barrington, Rhode Island); Yupeng CHEN (Sharon, Massachusetts); Hongchuan YU (Chestnut Hill, Massachusetts) |
| ABSTRACT | The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/316693 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 47/545 (20170801) A61K 47/6929 (20170801) A61K 47/6949 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1136 (20130101) C12N 2310/141 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156856 | LEVINE |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JON LEVINE (Oakland, California) |
| ABSTRACT | The disclosure is generally related to therapeutic compositions and methods for use in the treatment of somatosensory conditions, including pain and pruritis. In some aspects, the compositions comprise hyaluronic acid having a therapeutically effective molecular weight and one or more transdermal delivery agents. |
| FILED | Wednesday, May 24, 2023 |
| APPL NO | 18/323122 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/728 (20130101) Original (OR) Class A61K 47/20 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156864 | Dotti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gianpietro Dotti (Chapel Hill, North Carolina); Chuang Sun (Hangzhou, Zhejiang, China PRC); Peishun Shou (Cary, North Carolina); Yang Xu (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention provides chimeric antigen receptors (CAR) and methods of use in the treatment of diseases and disorders. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/773281 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464402 (20230501) A61K 2239/17 (20230501) A61K 2239/21 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/64 (20130101) C07K 16/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) Enzymes C12Y 207/01112 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156872 | CUERVO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ana Maria CUERVO (Bronx, New York); Evripidis GAVATHIOTIS (Flushing, New York) |
| ABSTRACT | The present disclosure provides methods of treating disease and disorders of the hematological system. The disclosure provides a method of expanding a population of hematopoietic stem cells (HSCs) while maintaining the population in an undifferentiated state comprising contacting the population of HSCs in the presence of a CMA activator for a period of time until a sufficient number of HSCs is obtained thereby producing an expanded HSC population. |
| FILED | Thursday, July 13, 2023 |
| APPL NO | 18/351655 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/421 (20130101) A61K 31/497 (20130101) A61K 31/498 (20130101) A61K 31/538 (20130101) A61K 35/28 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156902 | Pahan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rush University Medical Center (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kalipada Pahan (Skokie, Illinois) |
| ABSTRACT | The present disclosure generally relates to pharmaceutical compositions useful for the treatment of diseases and disorders. More particularly, the disclosure relates to pharmaceutical compositions comprising peptides that selectively inhibit NF-κB activation control or inhibit alpha(α)-synucleinopathy and neuronal loss in neurodegenerative diseases in which α-synuclein and/or NF-κB play a role in disease pathogenesis. The pharmaceutical compositions useful for the invention are preferably administered intranasally. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 18/550859 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156928 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiuli Wang (Duarte, California); Stephen J. Forman (Duarte, California); Don J. Diamond (Duarte, California) |
| ABSTRACT | T cells expressing a chimeric antigen receptor and a T cell receptor specific for CMV (bi-specific T cells) are described as a methods for using such cells in immunotherapy. In the immunotherapy methods, the recipient can be exposed to a CMV vaccine in order to expand and/or stimulate the be-specific T cells. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/424395 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 39/17 (20130101) A61K 39/245 (20130101) A61K 2039/585 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/71 (20130101) C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70521 (20130101) C07K 16/2803 (20130101) C07K 16/2833 (20130101) C07K 2317/73 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0637 (20130101) C12N 5/0638 (20130101) C12N 2501/998 (20130101) C12N 2710/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156931 | Howard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGE MASON UNIVERSITY (Fairfax, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marissa Ashton Howard (Richmond, Virginia); Lance Allen Liotta (Bethesda, Maryland); Fatah Kashanchi (Potomac, Maryland); Amanda Nicole Haymond Still (Manassas, Virginia); James Lawrence Erickson (Bristow, Virginia); Alessandra Luchini Kunkel (Burke, Virginia); Rachel Carter (Vienna, Virginia); Purva Vinayak GADE (Chantilly, Virginia) |
| ABSTRACT | The present invention relates to a non-destructive method comprising placing a tissue sample on a porous matrix, centrifuging the tissue sample under a negative pressure, applying a vacuum on the tissue sample, and collecting extracted extracellular vesicles from the tissue sample. The method does not cause physical rupturing of the tissue sample and maintains integrity of the tissue sample for further histopathological analysis. Moreover, the invention also provides a method of inducing an immune response of a host by immune sensitization using harvested extracellular vesicles. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/490053 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/10 (20130101) G01N 1/4077 (20130101) G01N 33/68 (20130101) G01N 2333/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156933 | McNeel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas McNeel (Madison, Wisconsin); Brian Olson (Madison, Wisconsin) |
| ABSTRACT | It is disclosed herein methods of treating prostate cancer comprising administering to the subject the combination of androgen deprivation therapy (ADT) and a vaccine directed against the androgen receptor or a fragment of the androgen receptor. Also disclosed are methods of increasing the efficacy of androgen deprivation therapy in a subject with prostate cancer comprising administering to the subject an effective amount of a vaccine against the androgen receptor or fragments thereof wherein the method inhibits, delays or reduces the growth of the prostate cancer and/or the development of castration-resistant prostate cancer. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491123 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 38/09 (20130101) A61K 39/0011 (20130101) A61K 39/001102 (20180801) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/545 (20130101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 16/3069 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156936 | Galen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); National Research Council of Canada (Ottawa, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. Galen (Eldersburg, Maryland); Thanh Pham (Baltimore, Maryland); Dacie R. Bridge (Blairsville, Pennsylvania); Jin Yuan Wang (Silver Spring, Maryland); Wangxue Chen (Ottawa, Canada) |
| ABSTRACT | The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle. |
| FILED | Tuesday, September 05, 2023 |
| APPL NO | 18/242319 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/05 (20130101) A61K 39/0266 (20130101) A61K 39/0275 (20130101) Original (OR) Class A61K 2039/523 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156937 | COLLAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | AMANDA L. COLLAR (ALBUQUERQUE, New Mexico); KATHRYN MARIE FRIETZE (ALBUQUERQUE, New Mexico) |
| ABSTRACT | The present invention is directed virus-like particles (VLPs) which are useful in immunogenic compositions and vaccines epitopes mediating protection are disclosed. Immunogenic peptides are identified and are displayed on virus-like particles, especially Qbeta, MS2, or AP205 VLPs which provide a potent immunogenic response in a patient or subject and enhanced protection from Ct infection in a patient or subject. Pharmaceutical compositions and vaccines are disclosed as are methods for providing an immunogenic response and/or vaccinating a patient or subject against Chlamydia trachomatis infections. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/278118 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/118 (20130101) Original (OR) Class A61K 47/6901 (20170801) A61K 2039/575 (20130101) A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Peptides C07K 14/005 (20130101) C07K 14/295 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2795/18122 (20130101) C12N 2795/18123 (20130101) C12N 2795/18134 (20130101) C12N 2795/18171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156939 | SHRESTA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | La Jolla Institute for Immunology (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sujan SHRESTA (La Jolla, California) |
| ABSTRACT | The present application relates to composition of matter, processes and use of composition of matter relating to flavivirus peptides and epitopes, for example, for therapeutic or preventative vaccination against a flavivirus, and/or for inducing, enhancing, or sustaining an immune response against a flavivirus, and/or for detecting an infection with or an exposure to a flavivirus in a subject. The flavivirus may be for example the Zika and/or Dengue virus. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/368949 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Peptides C07K 7/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156941 | Baric et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ralph Baric (Haw River, North Carolina); Long Ping Victor Tse (Chapel Hill, North Carolina); Rita Meganck (Chapel Hill, North Carolina) |
| ABSTRACT | This invention relates to mature flavivirus particles and methods of making and using the same. This invention further relates to flavivirus prM glycoproteins, nucleic acids encoding the same, as well as particles, populations, and compositions comprising the same. Also disclosed are methods of making and using the prM glycoproteins of the invention. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 18/550730 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/5256 (20130101) A61K 2039/5258 (20130101) A61K 2039/6075 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24122 (20130101) C12N 2770/24123 (20130101) C12N 2770/24134 (20130101) C12N 2770/24151 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/185 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156963 | Thomson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Thomson (Madison, Wisconsin); Jue Zhang (Madison, Wisconsin); Igor Slukvin (Verona, Wisconsin); Aditi Majumder (Madison, Wisconsin); Ho Sun Jung (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides genetically engineered immune cells that express an anti-GD2 chimeric antigen receptor, methods of generating these cells, and methods of treating tumors using the genetically engineered cells. |
| FILED | Tuesday, April 18, 2023 |
| APPL NO | 18/302636 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/461 (20230501) A61K 39/4613 (20230501) A61K 39/4614 (20230501) A61K 39/4631 (20230501) A61K 39/464471 (20230501) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/3084 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0642 (20130101) C12N 5/0645 (20130101) C12N 5/0646 (20130101) C12N 2506/45 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156970 | Jennings et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GRIFFITH UNIVERSITY (Nathan, Australia); University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Jennings (Nathan, Australia); Feda (En-Chi) Jen (Nathan, Australia); Kate Seib (Nathan, Australia); Evegny Semchenko (Nathan, Australia); Milton Kiefel (Nathan, Australia); Michael Apicella (Iowa City, Iowa) |
| ABSTRACT | This disclosure relates generally to Neisseria surface moieties. More particularly, the present disclosure relates to oligosaccharides corresponding to Neisseria lipooligosaccharides and to chimeric molecules comprising these moieties for eliciting an immune response to Neisseria organisms and/or for treating or inhibiting the development of Neisseria infections. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 18/550659 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/095 (20130101) A61K 47/62 (20170801) Original (OR) Class A61K 2039/6037 (20130101) A61K 2039/6081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156973 | Low et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip Stewart Low (West Lafayette, Indiana); Jeffery Nielsen (Lafayette, Indiana); Melissa Ann Kacena (Zionsville, Indiana) |
| ABSTRACT | Bone-targeting therapeutic compounds and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising a bone-targeting therapeutic compound; processes for preparing bone-targeting therapeutic compounds; and therapeutic methods to treat bone defects. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 18/547837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 47/645 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156982 | Mieszawska et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York); Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aneta J. Mieszawska (Long Island City, New York); Sylwia Dragulska (Brooklyn, New York); Mina Poursharifi (Brooklyn, New York); Marek Wlodarczyk (Brooklyn, New York); Ying Chen (Chappaqua, New York); John A. Martignetti (Chappaqua, New York); Maxier Acosta Santiago (Brooklyn, New York) |
| ABSTRACT | A method for forming peptide-coated nanoparticles. The nanoparticles are polylactic co-glycol polymer (PLGA). The coatings are self-assembled layers selected from RGDFFF (SEQ ID NO: 1); NGRFFF (SEQ ID NO: 2), EKHFFF (SEQ ID NO: 3) or TPP-KFF. A cargo molecule, such as a dye or a therapeutic may be bound to the nanoparticle. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506664 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5169 (20130101) A61K 9/5192 (20130101) A61K 47/6937 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156989 | Pyle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | April D. Pyle (Los Angeles, California); Courtney S. Young (Los Angeles, California); Melissa J. Spencer (Los Angeles, California) |
| ABSTRACT | The present disclosure provides a method of modifying a mutant dystrophin gene in the genome of a cell. The present disclosure further provides compositions and kits for modifying a mutant dystrophin gene in the genome of a cell. |
| FILED | Monday, April 24, 2023 |
| APPL NO | 18/305863 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2217/075 (20130101) A01K 2227/105 (20130101) A01K 2267/0306 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Original (OR) Class A61K 48/0091 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Peptides C07K 14/4708 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) C12N 15/113 (20130101) C12N 15/861 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156998 | Lewis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New york, New York); UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES (Kingston, Rhode Island); PHLIP, INC. (Kingston, Rhode Island) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New york, New York); UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES (Kingston, Rhode Island); PHLIP, INC. (Kingston, Rhode Island) |
| INVENTOR(S) | Jason S. Lewis (New York, New York); Dustin DEMOIN (New York, New York); Yana K. RESHETNYAK (Saunderson, Rhode Island); Oleg A. ANDREEV (Saunderson, Rhode Island); Nerissa VIOLA-VILLEGAS (New York, New York) |
| ABSTRACT | The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject. |
| FILED | Monday, July 17, 2023 |
| APPL NO | 18/353822 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 47/545 (20170801) A61K 47/547 (20170801) A61K 49/0056 (20130101) A61K 49/085 (20130101) A61K 49/124 (20130101) A61K 51/088 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157023 | Caliari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Steven R. Caliari (Charlottesville, Virginia); Erica Hui (Charlottesville, Virginia); Thomas H. Barker (Charlottesville, Virginia) |
| ABSTRACT | Disclosed are phototunable hydrogels, compositions that include the same, and methods for using the same for treating wounds and/or injuries, for inhibiting formation of scar tissue at wound sites, for inhibiting fibrosis in subjects in need thereof, for inhibiting lung fibrosis and/or scarring in subject in need thereof, for inhibiting formation of myofibroblasts from fibroblasts, and for inhibiting expression of α-smooth muscle actin (α-SMA) and/or type I collagen in fibroblasts. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 18/277752 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 26/008 (20130101) A61L 26/0023 (20130101) A61L 26/0061 (20130101) Original (OR) Class A61L 2300/252 (20130101) A61L 2400/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157030 | Alsberg |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eben Alsberg (Cleveland, Ohio) |
| ABSTRACT | An interpenetrating polymer network (IPN) structured hydrogel includes a crosslinked first natural polymer macromer with a first elasticity and an interpenetrating network of crosslinked second natural polymer macromers having a second elasticity higher than the first elasticity, the IPN structured hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/370106 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/26 (20130101) A61L 27/44 (20130101) Original (OR) Class A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/3608 (20130101) A61L 27/3834 (20130101) A61L 2300/236 (20130101) A61L 2300/252 (20130101) A61L 2300/412 (20130101) A61L 2300/414 (20130101) A61L 2400/16 (20130101) A61L 2430/40 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0084 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/002 (20130101) Derivatives of Natural Macromolecular Compounds C08H 1/06 (20130101) Compositions of Macromolecular Compounds C08L 5/04 (20130101) C08L 89/06 (20130101) C08L 2205/04 (20130101) C08L 2312/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157054 | MOSCOSO-VASQUEZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcela MOSCOSO-VASQUEZ (Charlottesville, Virginia); Jose GARCIA-TIRADO (Bern, Switzerland); Patricio COLMEGNA (Charlottesville, Virginia); Marc D. BRETON (Charlottesville, Virginia) |
| ABSTRACT | A method, system, and computer-readable medium are provided for an Automated Insulin Delivery (AID) system in which Model Predictive Control (MPC) thereof implements weighting of glucose target error relative to corresponding predicted blood glucose (BG) levels according to insulin on board (IOB). Accordingly, basal insulin infusion and available additional bolusing each in connection with glycemic disturbances such as unannounced meals can be proximally administered to maintain time in range (TIR) without incurring insulin stacking. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507253 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 2005/1726 (20130101) A61M 2230/201 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/17 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157101 | Gracias et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David H. Gracias (Baltimore, Maryland); Florin M. Selaru (Baltimore, Maryland); Arijit Ghosh (Baltimore, Maryland) |
| ABSTRACT | The present disclosure provides microscale devices, systems, and methods thereof for the delivery of therapeutic and prophylactic active agents (e.g., macromolecules). |
| FILED | Friday, March 18, 2022 |
| APPL NO | 18/550371 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0031 (20130101) A61K 9/0053 (20130101) A61K 47/36 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 31/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157139 | Wagner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Highland Instruments, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | Highland Instruments, Inc. (Somerville, Massachusetts) |
| INVENTOR(S) | Timothy Andrew Wagner (Somerville, Massachusetts); Laura Dipietro (Cambridge, Massachusetts); Uri Tzvi Eden (Somerville, Massachusetts) |
| ABSTRACT | The invention generally relates to methods for guiding physical therapy to a subject. In certain embodiments, methods of the invention involve providing stimulation to a subject's central nervous system to modulate one or more signals sent to or from a plurality of target regions of the subject. Methods of the invention further involve assessing the response of the plurality of target regions to the stimulation to determine if there is a differential response among the target regions to the stimulation, and providing focused physical therapy to at least one of the target regions based on the assessment of the response of the plurality of peripheral target regions to the stimulation. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392050 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0408 (20130101) A61N 1/36025 (20130101) Original (OR) Class A61N 2/006 (20130101) A61N 5/0622 (20130101) A61N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157166 | Greenberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Greenberg (Coppell, Texas); Rajiv Chopra (Dallas, Texas) |
| ABSTRACT | Metal-associated infections such as prosthetic joint infection (PJI) cause significant morbidity across the world. Infected implants frequently require surgical removal and weeks of antibiotics. This is in large part due to the formation of biofilm. Embodiments described herein utilize alternating magnetic fields (AMF) as a non-invasive approach for eradicating (i.e., significantly reducing) biofilm off of metal. Embodiments apply brief intermittent bursts of AMF given in concert with traditional antibiotics to synergistically remove biofilm off of metal. This effect is seen across common PJI-associated pathogens and with clinically used antibiotics. Utilizing AMF in an intermittent fashion has important implications for providing a non-invasive treatment that could be both safe and effective in patients. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 18/552709 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/30 (20130101) A61F 2002/30668 (20130101) A61F 2002/30719 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) Original (OR) Class A61N 2/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157323 | HEAD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Robert HEAD (La Jolla, California); Phillip T. ORDOUKHANIAN (La Jolla, California); Daniel R. SALOMON (La Jolla, California) |
| ABSTRACT | The present disclosure provides methods, compositions, and kits for methods that can improve techniques nucleic acid analysis, and can allow for more reliable and accurate targeted, multiplexed, high throughput sequencing. The methods, compositions, and kits can be used for sequencing target loci of nucleic acid. The methods, compositions, and kits disclosed herein can be used for assisted de novo targeted sequencing. The methods, compositions, and kits disclosed herein can also be used for library labeling for de novo sequencing and phasing. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/354924 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157333 | Allbritton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Nancy Allbritton (Seattle, Washington); Yuli Wang (Seattle, Washington) |
| ABSTRACT | Thin layer chromatography (TEC) devices for the analysis of pico-scale samples, methods for using the devices, and methods for fabricating the devices. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 18/549077 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) B01J 20/283 (20130101) Original (OR) Class B01J 20/3092 (20130101) B01J 20/28004 (20130101) B01J 20/28035 (20130101) B01J 20/28042 (20130101) B01J 2220/54 (20130101) B01J 2220/82 (20130101) B01J 2220/86 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/93 (20130101) G01N 33/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158351 | SRIDHAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Xavier University of Louisiana (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jayalakshmi SRIDHAR (New Orleans, Louisiana); Melyssa BRATTON (New Orleans, Louisiana); Rajesh KOMATI (Thibodaux, Louisiana) |
| ABSTRACT | The present disclosure relates to compounds that act as protein kinase inhibitors, especially RPS6K1 and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer, prostate cancer, lung cancer, and metastatic cancer. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/542220 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 209/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158355 | Matzuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Matzuk (Houston, Texas); Zhifeng Yu (Houston, Texas); Angela Ku (Houston, Texas); Justin Anglin (Houston, Texas); Feng Li (Houston, Texas); Damian Young (Houston, Texas); Ying-Chu Chen (Houston, Texas); Melek Ucisik (Houston, Texas); John Faver (Houston, Texas); Stephen Palmer (Houston, Texas); Rajesh Sharma (Houston, Texas); Choel Kim (Houston, Texas) |
| ABSTRACT | In one aspect, the present disclosure provides compounds which inhibit bromodomain testis (BRDT). In some embodiments, the compounds inhibit bromodomain-2 of BRDT. In another aspect, the present disclosure provides a method of inhibiting BRDT in a male subject, the method comprising administering to the male subject a therapeutically effective amount of a compound of the disclosure. In some embodiments, the method provides a contraceptive effect in the male subject. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 18/262037 |
| CURRENT CPC | Heterocyclic Compounds C07D 231/56 (20130101) Original (OR) Class C07D 401/04 (20130101) C07D 403/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158357 | Davidowitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OLIGOMERIX INC. (White Plains, New York) |
| ASSIGNEE(S) | Oligomerix, Inc. (White Plains, New York) |
| INVENTOR(S) | Eliot J. Davidowitz (West Hempstead, New York); James G. Moe (Stamford, Connecticut); Allen B. Reitz (Lansdale, Pennsylvania); Haiyan Bian (Princeton, New Jersey); Charles Gluchowski (Danville, California); James Hendrix (Wilmington, Massachusetts); Albert S. Yehaskel (Great Neck, New York); Mark E. McDonnell (Lansdale, Pennsylvania); H. Marie Loughran (Perkasie, Pennsylvania) |
| ABSTRACT | Novel quinazolinones useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 17/967344 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 239/91 (20130101) Original (OR) Class C07D 401/04 (20130101) C07D 401/14 (20130101) C07D 471/04 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158359 | CHAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of lllinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jefferson Kar Fai CHAN (Savoy, Illinois); Anuj K. YADAV (Urbana, Illinois) |
| ABSTRACT | A novel carboxylate luciferin substrate or methotrexate compound is disclosed as having at least one substituted benzyl ester group masking a carboxyl group. The substituted benzyl ester group may have a stabilizing substitution on the benzylic position. The stabilizing substitution on the benzylic position may be a methyl, phenyl group or a branched C3-C5 alkyl group. The luciferin substrate may provide an imaging agent or ABS may have NIR BL activity. Optionally, there is a trigger group at the para position or ortho position, or optionally both. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/498933 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/525 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) Heterocyclic Compounds C07D 277/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158379 | Davidowitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OLIGOMERIX INC. (White Plains, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eliot J. Davidowitz (West Hempstead, New York); James G. Moe (Stamford, Connecticut); Allen B. Reitz (Lansdale, Pennsylvania); Haiyan Bian (Princeton, New Jersey); Charles Gluchowski (Danville, California); James Hendrix (Hillsborough, New Jersey); Albert S. Yehaskel (Great Neck, New York); Mark E. McDonnell (Lansdale, Pennsylvania); H. Marie Loughran (Perkasie, Pennsylvania) |
| ABSTRACT | Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/721178 |
| CURRENT CPC | Heterocyclic Compounds C07D 307/80 (20130101) C07D 405/14 (20130101) C07D 409/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158384 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Green (Stanford, California); Alam Jahangir (Stanford, California); Mehrdad Shamloo (Stanford, California); Annelise E. Barron (Stanford, California); Jennifer S. Lin (Stanford, California); David Sperandio (Stanford, California); Amna T. Adam (Stanford, California); Heui Hye Park (Stanford, California); Neir Eshel (Stanford, California) |
| ABSTRACT | Provided herein are compounds, compositions, and methods for treating disorders (e.g., opioid addiction) using compounds disclosed herein, which are selective agonists of the cannabinoid 2 receptor (CB2R). |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 18/257167 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101) Original (OR) Class C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158397 | Chiosis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sloan-Kettering Institute for Cancer Research (New York, New York) |
| ASSIGNEE(S) | Sloan-Kettering Institute for Cancer Research (New York, New York) |
| INVENTOR(S) | Gabriela Chiosis (New York, New York); Huazhong He (New York, New York); Danuta Zatorska (Ericeira, Portugal) |
| ABSTRACT | Treatment of neurodegenerative diseases is achieved using small molecule purine scaffold compounds that inhibit Hsp90 and that possess the ability to cross the blood-brain barrier or are otherwise delivered to the brain. |
| FILED | Friday, May 26, 2023 |
| APPL NO | 18/202704 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) Heterocyclic Compounds C07D 473/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158402 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NOVITA PHARMACEUTICALS, INC. (New York, New York); CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | NOVITA PHARMACEUTICALS, INC. (New York, New York); CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Xin-Yun Huang (New York, New York); Christy Young Shue (Irvine, California) |
| ABSTRACT | Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one compound of any one of Formula I-a to I-n, II, II-a, II-b or III or a pharmaceutically acceptable salt thereof. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/393556 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/428 (20130101) A61K 31/433 (20130101) A61K 31/522 (20130101) Heterocyclic Compounds C07D 249/12 (20130101) C07D 277/82 (20130101) C07D 285/08 (20130101) C07D 405/12 (20130101) C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158421 | Schoenfisch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark H. Schoenfisch (Chapel Hill, North Carolina); Jae Ho Shin (Chapel Hill, North Carolina); Nathan Stasko (Chapel Hill, North Carolina) |
| ABSTRACT | The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications. |
| FILED | Monday, June 05, 2023 |
| APPL NO | 18/328983 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/167 (20130101) A61K 9/5115 (20130101) A61K 31/695 (20130101) A61K 41/0042 (20130101) A61K 47/59 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 10/00 (20130101) B82Y 30/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/10 (20130101) Original (OR) Class C07F 7/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158441 | HE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BRANDEIS UNIVERSITY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongjian HE (Waltham, Massachusetts); Bing XU (Newton, Massachusetts) |
| ABSTRACT | The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/498452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 35/00 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) C07K 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158445 | Pei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dehua Pei (Columbus, Ohio); Marina Buyanova (Columbus, Ohio) |
| ABSTRACT | Provided herein are novel cyclic cell penetrating peptides comprising at least two arginines and at least three hydrophobic amino acids. The disclosure also provides methods of using the cyclic cell penetrating peptides to transport cargo into cells and to treat diseases. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/278259 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) Peptides C07K 7/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158448 | Discher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis Discher (Philadelphia, Pennsylvania); Abdelaziz Jalil (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure includes methods and compositions that can efficiently enhance macrophage-mediated phagocytosis of target cells by inhibiting the SIRPα/CD47 interaction in a way that minimizes off-target toxicity. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/546695 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 14/001 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158450 | Asokan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravind Asokan (Chapel Hill, North Carolina); Mavis Agbandje-McKenna (Gainesville, Florida); Long Ping Victor Tse (Carrboro, North Carolina); Brittney Gurda (Collegeville, Pennsylvania) |
| ABSTRACT | The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488604 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/507 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 16/081 (20130101) C07K 2317/34 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158456 | Pereira et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heloise Anne Pereira (Edmond, Oklahoma); Anne KAUSU-JACOBI (Midwest City, Oklahoma); Gina L. GRIFFITH (McAlester, Oklahoma) |
| ABSTRACT | Peptide compounds, and compositions containing the peptide compounds, and methods for using the peptide compounds to treat infections, wounds, enhance acceptance of grafts such as skin grafts and organ grafts, and enhance the sensitivity of a bacterial pathogen to an antibiotic to which the bacterial pathogen has developed resistance. |
| FILED | Wednesday, September 13, 2023 |
| APPL NO | 18/466548 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/17 (20130101) A61K 38/1729 (20130101) A61K 45/06 (20130101) Peptides C07K 14/4723 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158466 | Chaikof et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Elliot Chaikof (Newton, Massachusetts); Richard D. Cummings (Brookline, Massachusetts) |
| ABSTRACT | This disclosure relates to PEGylated selectin inhibitors, compositions, and methods related thereto. In certain embodiments, the disclosure relates to glycopeptides that contain one or more modified amino acids conjugated to a saccharide or polysaccharide and a polyethylene glycol (PEG) moiety. In some embodiments, the disclosure relates to uses of the PEGylated glycopeptides as anti-inflammatory, anti-thrombotic, or anti-metastatic agents. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 18/272092 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) Peptides C07K 1/1077 (20130101) C07K 14/70564 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158471 | Walther et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frans J. Walther (Redondo Beach, California); Alan J. Waring (Irvine, California); Larry M. Gordon (Torrance, California) |
| ABSTRACT | Peptides suitable for preparation of lung surfactants are described. Examples include one that include a first fragment comprising the amino acid sequence of XWLXRALIKRIQAZI (SEQ ID NO: 1) or a first amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and a second fragment comprising the amino acid sequence of RZLPQLVXRLVLRXS (SEQ ID NO: 2) or a second amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2, wherein X is any amino acid but at least one amino acid at the X positions is not cysteine, or Z is any amino acid but at least one amino acid at the Z positions is not methionine. Surfactants that contain such peptides, and related compositions, methods of preparing and using the compositions are also described. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/355240 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 14/785 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158476 | Handa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hitesh Handa (Athens, Georgia); Marcus Goudie (Athens, Georgia); Jitendra Pant (Athens, Georgia); Bryan Grommersch (Alpharetta, Georgia); Sean Hopkins (Athens, Georgia) |
| ABSTRACT | Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405446 |
| CURRENT CPC | Peptides C07K 16/10 (20130101) Original (OR) Class C07K 19/00 (20130101) C07K 2317/24 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0065 (20130101) Enzymes C12Y 111/01007 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158478 | Wrammert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jens Wrammert (Atlanta, Georgia); Robert Kauffman (Atlanta, Georgia); Carl Davis (Atlanta, Georgia); Mehul Suthar (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to SARS-CoV-2 antibodies disclosed herein and specific binding fragments thereof, therapeutic and diagnostic uses, and compositions related thereto. In certain embodiments, this disclosure relates to antibodies disclosed herein and specific binding fragments thereof wherein the antibody or fragment specifically binds to an epitope expressed on a SARS-CoV-2 particle such as the spike protein or receptor binding domain. In certain embodiments, this disclosure relates to treating or preventing a SARS-CoV-2 or related coronavirus infection comprising administering an effective amount of an antibody disclosed herein or specific binding fragments thereof to a subject in need thereof. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 18/282409 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/1003 (20230801) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/52 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) G01N 33/577 (20130101) G01N 33/581 (20130101) G01N 33/582 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158479 | Choudhary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Alok K. Choudhary (Newark, New Jersey); Abraham Pinter (Lakewood, New Jersey) |
| ABSTRACT | This disclosure provides novel potent neutralizing antibodies directed against SARS-CoV-2 Omicron and other variants, related nucleic acids, related cells, related kits, related compositions, and related methods or uses. Also provided in this disclosure are novel combinations of anti-SARS-CoV-2 antibodies that exhibit synergistic effects in neutralizing SARS-CoV-2 variants. Furthermore, this disclosure provides novel chimeric immunogens for inducing effective immune responses against SARS-CoV-2 infections. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504832 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1003 (20230801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158488 | Butler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hackensack Meridian Health Center for Discovery and Innovation (Nutley, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Mathew Butler (Hackensack, New Jersey); Pradeep Ramalingam (Hackensack, New Jersey) |
| ABSTRACT | The described invention provides a method for rejuvenating an aging blood and vascular system comprising aging-associated hematopoietic defects in an aging hematopoietic microenvironment of bone marrow including deteriorating vascular integrity, reduced hematopoietic stem cell function, or both. The method includes administering to a subject a pharmaceutical composition comprising an inhibitor of a pro-aging angiocrine factor, a splice variant, or a fragment thereof, and a pharmaceutically acceptable carrier. The described invention has identified thrombospondin-1 as a candidate pro-aging factor. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/918675 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/44 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) Peptides C07K 16/205 (20130101) Original (OR) Class C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158511 | Arnaout |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Bosdton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Amin Arnaout (Chestnut Hill, Massachusetts) |
| ABSTRACT | Described herein are humanized antibodies that bind to Leukocyte integrin CD11b/CD18 (CD11b, αMβ2, CR3) with enhanced affinity, and methods of use thereof. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 18/283927 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) A61K 2039/545 (20130101) Peptides C07K 16/2845 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158564 | Coates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Wei You (Beijing, China PRC); Cheyenne Peltier (Ithaca, New York) |
| ABSTRACT | Hydrocarbonbackbone polymers with pendant quaternary ammonium groups and methods of making and using same. A polymer can be made by a ring-opening polymerization of quaternary ammonium bearing monomer(s), and, optionally, non-quaternary ammonium bearing monomer(s). A film including a polymer can be used as an anion exchange membrane in a device, such as, for example, a battery, a fuel cell, or the like. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/262677 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/05 (20170101) B01J 41/14 (20130101) B01J 47/12 (20130101) Heterocyclic Compounds C07D 295/037 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) Original (OR) Class C08G 2261/122 (20130101) C08G 2261/143 (20130101) C08G 2261/418 (20130101) C08G 2261/516 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/103 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158748 | Better et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kite Pharma, Inc. (Santa Monica, California); The United States of America, as represented by the Secretary, Department of Health and Human Serv (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc Better (Santa Monica, California); Steven A. Feldman (Bethesda, Maryland); Steven A. Rosenberg (Bethesda, Maryland) |
| ABSTRACT | Provided herein are methods for manufacturing T cells. In certain embodiments, methods for manufacturing T cells which express a cell surface receptor that recognizes a specific antigenic moiety on the surface of a target cell are provided. Also provided herein are populations of engineered T cells produced by the methods described herein and pharmaceutical compositions thereof. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/393414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/1774 (20130101) A61K 39/0011 (20130101) A61K 39/39558 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Peptides C07K 14/7051 (20130101) C07K 16/2896 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 2500/90 (20130101) C12N 2501/515 (20130101) C12N 2501/2302 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158750 | Jing et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Ran Jing (Boston, Massachusetts); Georg Q. Daley (Camebridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to stromal-free methods of NK cell differentiation. Also described herein are cells differentiated using stromal-free methods and compositions comprising such cells. In some embodiments, the cells can be genetically modified. In some embodiments, the cells or compositions comprising said cells can be administered to a patient to treat cancer or as a cellular replacement therapy to treat a condition. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 18/279336 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) Original (OR) Class C12N 2501/26 (20130101) C12N 2501/42 (20130101) C12N 2501/125 (20130101) C12N 2501/2303 (20130101) C12N 2501/2307 (20130101) C12N 2501/2315 (20130101) C12N 2502/1323 (20130101) C12N 2506/28 (20130101) C12N 2506/45 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158755 | Kuo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Calvin J. Kuo (Palo Alto, California); Shannon Choi (Redwood City, California) |
| ABSTRACT | Compositions and methods are provided for the culture of mammalian distal lung organoids that robustly preserve and propagate distal lung alveoli and bronchioles en bloc with infiltrating endogenous immune cells and mesenchyme as a cohesive unit without artificial reconstitution, allowing analysis of the dynamics of tissue-level inflammation upon respiratory infection. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 18/289881 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0688 (20130101) Original (OR) Class C12N 2501/11 (20130101) C12N 2502/11 (20130101) C12N 2502/1352 (20130101) C12N 2513/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158773 | Dong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Cprporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Cprporation (Boston, Massachusetts) |
| INVENTOR(S) | Min Dong (Weatogue, Connecticut); Pyung-Gang Lee (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are modified Clostridial Botulinum neurotoxin (BoNT) polypeptides with a modified protease domains of Clostridial Botulinum serotype A1 or A2. Modifications include substitution amino acid mutations, isolated modified protease domains, chimeric molecules, pharmaceutical compositions, and methods of using the same are also disclosed. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 18/282215 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/66 (20130101) A61K 38/4893 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Original (OR) Class Enzymes C12Y 304/24069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158778 | MARINOV et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Georgi MARINOV (Redwood City, California); William J. GREENLEAF (Menlo Park, California); Tong WU (Chicago, Illinois); Chuan HE (Chicago, Illinois) |
| ABSTRACT | The disclosure pertains to a method for isolating DNA fragments that contain a binding site for a guide-RNA of an RNA-guided endonuclease. The method comprises contacting the RNA-guided endonuclease with a target double-stranded DNA, thereby producing a single stranded DNA (ss-DNA) at the site to which the guide-RNA binds. The ssDNA is then reacted with kethoxal or an analog thereof modified by a chemoselective group, thereby adding the chemoselective group to any unpaired guanine based within the ssDNA. A first binding member of a specific binding pair is linked to the chemoselective group, for example, via a cycloaddition reaction. The DNA is fragmented and the DNA fragments that contain the binding sites for the guide-RNA are enriched using a support that comprises a second binding member of the specific binding pair. The method can be used to identify binding sites for a guide-RNA thereby identifying off-target binding sites. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 18/280653 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158779 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Andrew Vito Anzalone (Cambridge, Massachusetts); Jonathan Ma Levy (Brookline, Massachusetts); Xin Gao (Cambridge, Massachusetts); Christopher J. Podracky (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides systems, compositions, and methods for simultaneously editing both strands of a double-stranded DNA sequence at a target site to be edited. In some aspects, the systems comprise a first and second prime editor complex, wherein each of the first and second prime editor complexes comprises (1) a prime editor comprising (i) a nucleic acid programmable DNA binding protein (napDNAbp), and (ii) a polypeptide having an RNA-dependent DNA polymerase activity; and (2) a pegRNA comprising a spacer sequence, gRNA core, a DNA synthesis template, and a primer binding site, wherein the DNA synthesis template encodes a desired DNA sequence or a complement thereof, wherein the desired DNA sequence and the complement thereof form a duplex comprising an edited portion which integrates into the target site to be edited. In some aspects, the systems comprise a first, second, third, and fourth prime editor complex, each comprising a prime editor and a PEgRNA. Also provided herein are methods for simultaneously editing both strands of a double-stranded DNA sequence at a target site to be edited. Further provided herein are pharmaceutical compositions, polynucleotides, vectors, cells, and kits. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/534489 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158793 | Blazeck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John James Blazeck (Atlanta, Georgia); Andrew J. Kristof (Atlanta, Georgia) |
| ABSTRACT | The present disclosure relates to CRISPR interference (CRISPRi) systems and uses thereof. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506430 |
| CURRENT CPC | Peptides C07K 14/4703 (20130101) C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158807 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (CORK, Ireland) |
| ABSTRACT | Circular RNA and methods and constructs for engineering circular RNA are disclosed. In some embodiments, the circular RNA includes the following elements arranged in the following sequence: a) a 3′ Group I self-splicing intron fragment, b) an internal ribosome entry site (IRES), c) a protein coding region or noncoding region, and d) a 5′ Group I self-splicing intron fragment. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/544160 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158810 | FENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Guoping FENG (Cambridge, Massachusetts); Dheeraj ROY (Cambridge, Massachusetts); Ying ZHANG (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure features compositions and methods for ameliorating cognitive impairments associated with neuropsychiatric disorders, particularly those associated with anterodorsal (AD) thalamus hyperexcitability in the brain of a subject. Various embodiments of the disclosure provide for personalized and targeted therapeutic approaches for screening, diagnosing, preventing, and treating cognitive impairments and neuropsychiatric disorders. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/394297 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5513 (20130101) A61K 48/0058 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Peptides C07K 14/723 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158814 | Scott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan Alexander Scott (Evanston, Illinois); Sijia Yi (Evanston, Illinois) |
| ABSTRACT | The present invention provides nanocarriers for delivering polynucleotide sequences to cells, specifically immune cells, including dendritic cells and methods of use. The methods provide improved delivery and reduced toxicity over prior methods. The method of the present disclosure provide a system for delivering nucleic acids to a cell, consisting of a synthetic PEG-b-PPS-linker-DP polymer for producing nanostructures comprising a poly(ethylene glycol)-blockpoly (propylene sulfide) copolymer (PEG-b-PPS) conjugated with a dendritic-specific branched cationic peptide (DP). The system provides a non-toxic in-vitro method of delivering a polynucleotide to immune cells, including dendritic cells, comprising of contacting the cell in cell culture medium with a nanocarrier wherein the method is non-toxic to the cells. The methods described in the invention can be used for treating a subject in need of gene therapy, comprising administering to the subject an effective amount of the system comprising of a polynucleotide, wherein the polynucleotide contains a gen of interest for gene therapy. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 18/551095 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6455 (20170801) A61K 47/6935 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0639 (20130101) C12N 15/88 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158839 | NGUYEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Huy Quoc NGUYEN (Cambridge, Massachusetts); Shyamtanu CHATTORAJ (Cambridge, Massachusetts); Chao-ting WU (Cambridge, Massachusetts); George M. CHURCH (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure is generally directed to methods for obtaining sequence information at nucleotide resolution with spatial information directly from chromosome(s) in situ. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 18/281908 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158840 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| INVENTOR(S) | Siyuan WANG (New Haven, Connecticut); Bing YANG (New Haven, Connecticut); Mengwei HU (New Haven, Connecticut) |
| ABSTRACT | Provided herein are methods for decoding nucleic acid barcodes in situ by using rolling circle amplification and labeled probes. Also provided herein are methods of performing an in situ genetic screen, using the nucleic acid barcode decoding techniques described herein. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 18/282206 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2320/12 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class C12Q 1/6846 (20130101) C12Q 1/6876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158846 | Gundlach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| INVENTOR(S) | Jens Gundlach (Seattle, Washington); Ian M. Derrington (Seattle, Washington); Andrew Laszlo (Seattle, Washington); Elizabeth Manrao (Seattle, Washington) |
| ABSTRACT | The present disclosure generally relates to the methods and compositions to efficiently analyze polymer characteristics using nanopore-based assays. Specifically disclosed is a method for generating reference signals for polymer analysis in a nanopore system, wherein the nanopore system has a multi-subunit output signal resolution. The method comprises translocating a reference sequence through a nanopore to generate a plurality of reference output signals, wherein each possible multi-subunit sequence that can determine an output signal appears only once in the reference sequence. The output signals are compiled into a reference map for nanopore analysis of an analyte polymer. Also provided are methods and compositions for calibrating the nanopore system for optimized polymer analysis. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/486103 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/447 (20130101) G01N 33/48721 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158863 | KASSIS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Amin I. KASSIS (Chestnut Hill, Massachusetts) |
| ABSTRACT | Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having cancer are also provided. Methods and compositions for diagnosing the presence of an infectious agent in an individual and/or for identifying an infectious agent-specific signature in an infected individual are provided. Methods and compositions for diagnosing the presence of a disease in an individual are also provided. Methods and compositions for identifying a disease-specific signature in an individual having the disease are also provided. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/210213 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/569 (20130101) G01N 33/5023 (20130101) G01N 33/5047 (20130101) G01N 33/5052 (20130101) G01N 33/5055 (20130101) G01N 33/5091 (20130101) G01N 33/57407 (20130101) G01N 33/57434 (20130101) G01N 33/57449 (20130101) G01N 33/57484 (20130101) G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158865 | Pietenpol et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Pietenpol (Nashville, Tennessee); Brian Lehmann (Nashville, Tennessee); Josh Bauer (Nashville, Tennessee); Xi Chen (Nashville, Tennessee) |
| ABSTRACT | In one aspect provided herein are methods of determining a triple negative breast cancer (TNBC) subtype in an individual in need thereof comprising determining expression of one or more genes in one or more TNBC cells of the individual; and comparing the expression of the one or more genes in the TNBC cells with the expression of the one or more genes in a control. In another aspect, the methods are directed to determining a treatment protocol for the TNBC patient based on the TNBC subtype. In another aspect, the methods are directed to predicting whether an individual will benefit from a treatment for a particular TNBC subtype. In yet another aspect, the invention is directed to a method of determining whether an agent can be used to treat a TNBC subtype. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/381126 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159462 | Andrews et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| ASSIGNEE(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| INVENTOR(S) | Robert R. Andrews (Norfolk, Massachusetts); Herman E. Snyder (W. Lafayette, Indiana); William J. Merritt (Danvers, Massachusetts); Evan P. Ordway (Salem, Massachusetts); Clair Strohl (Emmaus, Pennsylvania) |
| ABSTRACT | The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted to from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/411799 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/16 (20130101) Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 3/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159668 | Vakoc et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Vakoc (Arlington, Massachusetts); Norman Lippok (Cambridge, Massachusetts) |
| ABSTRACT | An apparatus, including: an electromagnetic radiation source producing radiation for illuminating a sample located at an optical path depth, the electromagnetic radiation source providing the radiation to the sample to facilitate determining the optical path depth within the sample: an interferometer including: a reference arm a first portion of the radiation is delivered to, a sample arm to which a second portion of the radiation is delivered, a first optical subsystem coupled to the sample arm to interrogate the sample with the radiation delivered to the sample arm and to collect backscattered radiation from the sample, and a second optical subsystem coupled to the reference arm and the first optical subsystem to generate interference fringes between the collected backscattered radiation and the radiation delivered to the reference arm; and a data collection and processing system configured to compute the optical path depth of the sample from the received interference fringes. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/755452 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159734 | Lindsay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RECOGNITION ANALYTIX, INC. (PHOENIX, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart Lindsay (Phoenix, Arizona); Peiming ZHANG (Phoenix, Arizona) |
| ABSTRACT | The present disclosure relates to a device, system and method for sensing functional motions of a single protein molecule via direct attachment of one or more electrodes to the molecule. The present disclosure also relates to an array, a system comprising an array and method for sequencing a biopolymer using an array. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468210 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4146 (20130101) G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159749 | LIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AMBERGEN, INC. (Watertown, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | AMBERGEN, INC. (Watertown, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | MARK J. LIM (Reading, Massachusetts); HEATHER P. OSTENDORFF (Framingham, Massachusetts); KENNETH J. ROTHSCHILD (Newton, Massachusetts); DONALD B. BLOCH (Newton, Massachusetts) |
| ABSTRACT | Methods and compositions are described for the diagnosis of primary biliary cirrhosis. Novel autoantigens are described for use in assays which employ test samples from individuals. |
| FILED | Tuesday, November 28, 2023 |
| APPL NO | 18/522114 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 2333/47 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159750 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MARSHALL UNIVERSITY RESEARCH CORPORATION (Huntington, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei LI (Huntington, West Virginia); Hong YUE (Huntington, West Virginia) |
| ABSTRACT | Methods for diagnosis and treatment of COVID-19 acuity in a subject include the identification of a subject as having Nan increased expression level and/or activity of thymidine phosphorylase in a biological sample obtained from the subject. An effective amount of a therapeutic agent that reduces the expression level or activity of thymidine phosphorylase can the be administered to the subject. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 18/273158 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/48 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/165 (20130101) G01N 2333/91142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159776 | E. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (Fort Worth, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | O'Bryant Sid E. (Aledo, Texas) |
| ABSTRACT | The present invention includes methods for detecting neurodegeneration and treating a subject that is of Mexican American or non-Hispanic white origin, the method comprising: obtaining a blood, plasma or serum sample; determining ethnicity of the subject; measuring one or more biochemical biomarkers; or measuring one or more protein biomarkers, or measuring both biochemical biomarkers and protein biomarkers; comparing the level of expression from the sample with a statistical sample representative of the subject of Mexican American or of non-Hispanic white origin, suspected of having neurodegeneration; and treating the subject with a treatment that targets neurodegeneration or neuronal injury, wherein the neurodegeneration or neuronal injury is measured by [18F]-fluorodeoxyglucose-PET, structural MRI, or CSF total tau. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 18/549183 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 33/6869 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/62 (20130101) G01N 2333/525 (20130101) G01N 2333/605 (20130101) G01N 2333/745 (20130101) G01N 2333/5409 (20130101) G01N 2333/5412 (20130101) G01N 2333/5418 (20130101) G01N 2333/5428 (20130101) G01N 2800/56 (20130101) G01N 2800/2814 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159778 | Leung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Jewish Health (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald Y.M. Leung (Denver, Colorado); Elena Goleva (Denver, Colorado); Evgeny Berdyshev (Littleton, Colorado) |
| ABSTRACT | The present invention is related to novel methods for identifying a population of subjects that are at risk for developing of atopic allergic diseases, such as atopic dermatitis, and to the prevention and treatment of these allergic diseases. |
| FILED | Tuesday, June 06, 2023 |
| APPL NO | 18/329769 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 2405/04 (20130101) G01N 2405/08 (20130101) G01N 2800/24 (20130101) G01N 2800/202 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159942 | Gopinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Juliet T. Gopinath (Boulder, Colorado); Samuel D. Gilinsky (Boulder, Colorado); Mo Zohrabi (Longmont, Colorado); Victor M. Bright (Boulder, Colorado); Omkar D. Supekar (Painted Post, New York); Wei Yang Lim (Eden Prairie, Minnesota) |
| ABSTRACT | A microlens array includes a bottom electrode chip, a sidewall electrode chip, and a top glass chip configured to cooperate to define an array of cavities, each one of the array of cavities containing a fluid. The fluid is a mixture of a polar liquid and a non-polar liquid, in contact with one of the array of sidewalls at a contact angle. The bottom electrode chip includes a plurality of electrical contacts. The sidewall electrode chip includes an array of sidewalls, each including an electrode layer and an insulator layer. When a voltage is applied across the fluid contained a cavity via electrical contacts and the electrode layer of the cavity, the contact angle of the fluid with the sidewall is modified, in embodiments without affecting the contact angle of fluid contained in other ones of the plurality of array of cavities. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/508114 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/14 (20130101) G02B 3/0056 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/294 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160231 | Ismagilov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. Ismagilov (Chicago, Illinois); Bo Zheng (Chicago, Illinois); Cory John Gerdts (Chicago, Illinois) |
| ABSTRACT | The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/395300 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 25/314 (20220101) B01F 33/3021 (20220101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/0059 (20130101) B01J 2219/00522 (20130101) B01J 2219/00585 (20130101) B01J 2219/00599 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/0293 (20130101) B01L 3/502746 (20130101) B01L 3/502784 (20130101) B01L 2200/0673 (20130101) B01L 2300/0816 (20130101) B01L 2300/0838 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/38 (20130101) G01N 35/08 (20130101) G01N 2035/1034 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 7/0694 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161247 | LECOQ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ALLEN INSTITUTE (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerome Anthony-Jean LECOQ (Seattle, Washington); Michael David OLIVER (Seattle, Washington); Joshua Handman SIEGLE (Seattle, Washington); Christof KOCH (Seattle, Washington) |
| ABSTRACT | A facility for transforming a subject data item sequence is described. The facility accesses a trained relationship model. For each of a plurality of subject items of the subject data item sequence, the facility: selects a first contiguous series of items of the subject data item sequence immediately before the subject data item; selects a second contiguous series of items of the subject data item sequence immediately after the subject data item; and applies the trained relationship model to the selected first and second contiguous series of data items to obtain a denoised version of the subject data item. The facility then assembles the obtained denoised subject data items into a denoised data item sequence. |
| FILED | Wednesday, October 07, 2020 |
| APPL NO | 17/772971 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) G06T 5/70 (20240101) Original (OR) Class G06T 2200/04 (20130101) G06T 2207/10016 (20130101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161291 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of The Stevens Institute of Technology (Hoboken, New Jersey); The Trustees of the Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinho Kim (Jersey City, New Jersey); Seyed Mohammad Mir (Hoboken, New Jersey); Jiawen Chen (Hoboken, New Jersey); Gordana Vunjak-Novakovi (New York, New York); Meghan Pinezich (New York, New York); Maria Hudock (New York, New York) |
| ABSTRACT | A bioreactor is disclosed that can be used to study living tissues (e.g., lung tissues) in an environment that mimics the natural environment. Pressure, flow and force modules enable imitation of in vivo conditions. An integrated imaging module allows for the airway tissues and cells of interest to be visualized and monitored continuously and non-destructively at the single-cell level. A method of use of the created systems can be utilized to quantify mucociliary fluid movements across the luminal surface of in vitro-cultured human airway tissue via in situ particle tracking and analysis is also disclosed. Another method of use of systems created in accordance with an embodiment of the present invention is to generate in vitro-cultured human airway tissue with severely impaired mucociliary flow by depositing thick viscous mucus-mimetic fluid on to the airway lumen. Methods of de-epithelialization and replacement of living cells are also disclosed. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505986 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/30004 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161295 | BUCKLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545542 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161296 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545550 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161297 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545563 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161301 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Nathaniel Braman (Cleveland, Ohio); Vidya Sankar Viswanathan (Shaker Heights, Ohio) |
| ABSTRACT | The present disclosure relates to a method. The method includes accessing data having one or more segmented images identifying one or more lesions and/or a plurality of blood vessels associated with the lesions. Respective ones of the blood vessels correspond to one or more centerlines and one or more constituent branches associated with the one or more lesions. The one or more segmented images are derived from one or more radiological images of a patient having cancer. One or more vascular radiology features are extracted using the centerlines, the constituent branches, and the one or more lesions. The one or more vascular radiology features relate to a quantification of the plurality of blood vessels or a shape of the plurality of blood vessels. The one or more vascular radiology features are used to determine a medical prediction associated with an outcome of the patient to cyclin-dependent kinase (CDK) inhibitor therapy. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500473 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0016 (20130101) Original (OR) Class G06T 2207/10116 (20130101) G06T 2207/30056 (20130101) G06T 2207/30068 (20130101) G06T 2207/30096 (20130101) G06T 2207/30101 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161307 | Dao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NANYANG TECHNOLOGICAL UNIVERSITY (Singapore, Singapore); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (cAMBRIDGE, Massachusetts); BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ming Dao (Cambridge, Massachusetts); Subra Suresh (Singapore, Singapore); George Karniadakis (Providence,, Rhode Island); Shengze Cai (Providence, Rhode Island); He Li (Providence, Rhode Island) |
| ABSTRACT | Methods and systems for estimating fluid flow characteristics are provided. In one embodiment, a method is provided that includes receiving a plurality of images of fluid flow at a plurality of times. The images may be analyzed with a machine learning model to predict one or more physical characteristics of the fluid flow, such as a velocity field, a pressure field, and/or a stress field. A loss measure may be calculated for the physical characteristics based on physical fluid flow constraints, boundary condition constraints, and/or data mismatch constraints. The machine learning model may be updated based on the loss value. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 18/282679 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/20 (20130101) Original (OR) Class G06T 2207/10016 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161319 | Ingle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Atul Ingle (Madison, Wisconsin); Sacha Jungerman (Madison, Wisconsin); Yin Li (Madison, Wisconsin); Mohit Gupta (Madison, Wisconsin) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for estimating a depth and orientation of a portion of a scene using a single-photon detector and diffuse light source are provided. In some embodiments, a system comprises: a light source; an image sensor comprising a pixel having a field of view of at least one degree; a hardware processor programmed to: cause the light source to emit a sequence of n defocused pulses toward the scene; receive, from the pixel, information indicative of arrival times of light from the scene; generate a transient histogram using the information indicative of arrival times of light from the scene; and estimate one or more properties of a portion of the scene within the field of view of the pixel based on the transient histogram, wherein the one or more properties of the portion of the scene includes at least a depth. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/983925 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4865 (20130101) G01S 17/10 (20130101) Image Data Processing or Generation, in General G06T 7/13 (20170101) G06T 7/521 (20170101) Original (OR) Class G06T 2207/10028 (20130101) Pictorial Communication, e.g Television H04N 5/2256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161652 | VEDULA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Satyanarayana S. VEDULA (Baltimore, Maryland); Shameema SIKDER (Chevy Chase, Maryland); Gregory D. HAGER (Baltimore, Maryland); Tae Soo KIM (Baltimore, Maryland); Chien-Ming HUANG (Baltimore, Maryland); Anand MALPANI (Baltimore, Maryland); Kristen H. PARK (Baltimore, Maryland); Bohua WAN (Baltimore, Maryland) |
| ABSTRACT | A method includes determining one or more metrics of a surgical task being performed by a surgeon based at least partially upon a type of the surgical task being performed and a video of the surgical task being performed. The method also includes determining a surgical skill of the surgeon during the surgical task based at least partially upon the video, the one or more metrics, or a combination thereof. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 18/281337 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/02 (20130101) G09B 23/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161653 | German et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CFD Research Corporation (Huntsville, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carrie Lynn German (Huntsville, Alabama); Balabhaskar Prabhakarpandian (Madison, Alabama); Ketan Harendrakumar Bhatt (Huntsville, Alabama); Ashley Gilbert Helser (Huntsville, Alabama) |
| ABSTRACT | The method involves computationally modeling a placenta by simulating physical placenta models with computational in silico models. The simulated data is compared with actual data from the physical models, and the simulation is iterated until a match is achieved. The method may also include calibrating diffusion parameters for testing substances, and configuring the models for analyzing instances of fluid-induced shear and substance transport. The simulated data may be used to obtain maternal-fetal pharmacokinetic in silico placenta models, and the method may be used to obtain predictions for time-dependent concentrations of molecules in fetal circulation. The computational models may consider instances of fluid-diffusive transport and carrier-mediated transport in calculations and determinations of transport characteristics and values of different testing substances. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511347 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/281 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161733 | Tran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ngoc Minh Tran (Dublin, Ireland); Hessel Tuinhof (Dublin, Ireland); Beat Buesser (Dublin, Ireland) |
| ABSTRACT | A method, computer program product, and computer system for generation of training examples for training an automatic speech recognizer. Embodiments of the present invention can receive a training dataset of original audio signals and generate training examples for training an automatic speech recognizer based, at least in part, on a constructed imperceptible space for an original audio signal of the original audio signals and adversarial audio examples in the constructed imperceptible space. Embodiments of the present invention can then generate an imperceptible and adversarial audio example to an adversarial trainer for the automatic speech recognizer. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 18/054670 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/01 (20130101) G10L 15/063 (20130101) Original (OR) Class G10L 15/065 (20130101) G10L 25/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161868 | Diehn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leiand Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California); Mahya Mehrmohamadi (Moraga, California); Mohammad Shahrokh Esfahani (Mountain View, California) |
| ABSTRACT | Methods are provided for non-invasively determining the expression of genes of interest by inference and the use thereof in cancer classification and stratification for treatment. The methods are based on an integrated analytic method, where a single biomarker is derived from promoter fragment entropy (PFE) and analysis of nucleosome depleted regions (NDR) depth. In some embodiments the methods use only noninvasive blood draws, and robustly identify which patients will achieve durable clinical benefit from immune checkpoint inhibition, what the cancer subtype classification is and/or what the tumor burden is. In an embodiment, the methods further comprise selecting a treatment regimen for the individual based on the analysis. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980254 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6813 (20130101) C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161926 | Krebs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); Wisconsin Alumni Research Foundation (Madison, Wisconsin); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Olivia Krebs (Cleveland Heights, Ohio); Pallavi Tiwari (Waunakee, Wisconsin); Germán Corredor (Beachwood, Ohio) |
| ABSTRACT | The present disclosure relates to a method. The method includes accessing a segmented digitized pathology image corresponding to a high grade glioma (HGG) patient having a first biological sex. The segmented digitized pathology image identifies nuclei. The nuclei are classified as tumor infiltrating lymphocytes (TILs) or non-TILs. Sex specific features related to the nuclei identified as the TILs and the non-TILs are extracted. The sex specific features characterize a spatial organization of the TILs and the non-TILs. The sex specific features are operated on with a sex specific machine learning model corresponding to the first biological sex to generate a sex specific patient risk score. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/493862 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/00 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161933 | BAHARLOO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raheleh BAHARLOO (Gainesville, Florida); Patrick J. TIGHE (Gainesville, Florida); Parisa RASHIDI (Gainesville, Florida); Jose C. PRINCIPE (Gainesville, Florida); Arash ANDALIB (Gainesville, Florida) |
| ABSTRACT | Various embodiments of the present disclosure provide systems and methods for prediction of a risk for mild or severe persistent post-operative pain (POP) for an individual of interest. A risk prediction may be determined based at least in part on a cohort predictive model. The cohort predictive model is associated with a surgical type cohort and initialized with historical multivariate intra-operative vital sign data associated with binary classifications of mild or severe persistent post-operative pain. Using complex higher-order singular value decomposition, phase information for the historical multivariate intra-operative vital sign data is determined. A relationship between phase information and mild or severe persistent POP is then determined using discriminant analysis. Subsequently, phase information for multivariate intra operative vital sign data for an individual of interest is provided to a cohort predictive model, which uses the determined relationship to classify the individual of interest. The risk prediction then comprises the classification. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 18/552486 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162026 | Ouyang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zheng Ouyang (West Lafayette, Indiana); Yue Ren (West Lafayette, Indiana); Ziqing Lin (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/526244 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/167 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 436/24 (20150115) Y10T 436/255 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240156850 | Zahnow et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cynthia Zahnow (Bel Air, Maryland); Stephen B. Baylin (Baltimore, Maryland); Michael Topper (Baltimore, Maryland); Meredith Stone (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating solid tumors. In a specific embodiment, a method for treating a solid tumor in a patient having cancer comprises the step of administering to the patient a demethylating agent, a histone deacetylase (HDAC) inhibitor and a checkpoint inhibitor. |
| FILED | Wednesday, March 29, 2023 |
| APPL NO | 18/192226 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/706 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156929 | COOPER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laurence J.N. COOPER (Houston, Texas); Hiroki TORIKAI (Houston, Texas); Ling ZHANG (Houston, Texas); Helen HULS (Houston, Texas); Feng WANG-JOHANNING (Bastrop, Texas); Lenka HURTON (Houston, Texas); Simon OLIVARES (Houston, Texas); Janani KRISHNAMURTHY (Houston, Texas) |
| ABSTRACT | The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465547 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/00111 (20180801) A61K 39/00117 (20180801) A61K 39/00119 (20180801) A61K 39/001104 (20180801) A61K 39/001106 (20180801) A61K 39/001109 (20180801) A61K 39/001112 (20180801) A61K 39/001113 (20180801) A61K 39/001119 (20180801) A61K 39/001124 (20180801) A61K 39/001129 (20180801) A61K 39/001151 (20180801) A61K 39/001164 (20180801) A61K 39/001168 (20180801) A61K 39/001171 (20180801) A61K 39/001174 (20180801) A61K 39/001181 (20180801) A61K 39/001182 (20180801) A61K 39/001194 (20180801) A61K 2039/505 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) Peptides C07K 14/5443 (20130101) C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 16/30 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157022 | Kudela et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Damien Kudela (Santa Barbara, California); Galen D. Stucky (Santa Barbara, California); Anna May-Masnou (Barcelona, Spain); Gary Bernard Braun (San Diego, California); James H. Morrissey (Champaign, Illinois); Stephanie A. Smith (Urbana, Illinois) |
| ABSTRACT | A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting. |
| FILED | Wednesday, May 31, 2023 |
| APPL NO | 18/204233 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/595 (20170801) A61K 47/6923 (20170801) A61K 47/6935 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/02 (20130101) A61L 24/046 (20130101) Original (OR) Class A61L 2300/404 (20130101) A61L 2300/418 (20130101) A61L 2400/04 (20130101) A61L 2400/12 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2982 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157346 | MIRKIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. MIRKIN (Wilmette, Illinois); Yijin KANG (Naperville, Illinois); Liliang HUANG (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are trimetallic PtAu-based nanocatalysts for electrochemical hydrogen production and screening methods thereof. Nanocatalysts are produced through a polymer pen lithography (PPL) technique, which enables large-scale fabrication of nanoparticle arrays with programmable specifications such as size, shape, and composition, providing a route to the high-throughput screening and discovery of new catalysts. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/217127 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) B01J 23/8933 (20130101) Original (OR) Class B01J 35/393 (20240101) B01J 37/08 (20130101) B01J 37/0221 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) C25B 15/02 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157362 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arum Han (College Station, Texas); Adrian Guzman (College Station, Texas); Han Zhang (College Station, Texas); Jose Wippold (College Station, Texas); Jing Dai (College Station, Texas) |
| ABSTRACT | A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/382591 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2200/16 (20130101) B01L 2200/027 (20130101) B01L 2200/0647 (20130101) B01L 2400/086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157366 | SALOMON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MeMed Diagnostics Ltd. (Tirat HaCarmel, Israel) |
| ASSIGNEE(S) | MeMed Diagnostics Ltd. (Tirat HaCarmel, Israel) |
| INVENTOR(S) | Noga SALOMON (Haifa, Israel); Kfir OVED (Hof HaCarmel, Israel); Yana KHALFIN (Haifa, Israel); Omer Nahum KATZENELSON (Atlit, Israel); Amir GELMAN (Kibbutz Nir-David, Israel); Moran BROUK RUDICH (M.P. Misgav, Israel); Roy NAVON (Tel-Aviv, Israel); Assaf COHEN-DOTAN (Natania, Israel); Eran EDEN (Haifa, Israel); Salit TZABAN (Nofit, Israel); Arnon ZANGVIL (Tel Aviv-Yafo, Israel); Ofer HALBREICH (Tel-Aviv, Israel); Matthew FENWICK (Mount Waverley, Australia); Adrian Charles Ian SCOTT-MURPHY (Surrey Hills, Australia); Matthew Hou-Pou YEUNG (Nunawading, Australia); James William LUTHER (Milan, Italy); Barbara TORNAGHI (Monza, Italy); Andrea BESANA (Seveso, Italy); Thomas Sanelli CRUGNALE (Lysterfield, Australia) |
| ABSTRACT | In a cartridge device for analyzing a body liquid, a first member of the cartridge has two or more wells for performing assays, and a second member of the cartridge has a compartment for holding one or more disposable pipette tips. |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/419606 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/150022 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/50853 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/10 (20130101) G01N 35/0098 (20130101) G01N 35/0099 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157442 | Zachariah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Michael R. Zachariah (Riverside, California); Reza Abbaschian (Riverside, California); Pankaj Ghildiyal (Riverside, California); Steven Herrera (Riverside, California); Prithwish Biswas (Riverside, California) |
| ABSTRACT | A method and system are disclosed of assembling metal particles into nanoparticles. The method includes electromagnetically levitating the metal particles; inductively heating the electromagnetically levitated metal particles beyond their melting point into metal droplets; and wherein an evaporation flux achieved at a surface of the metal droplets result in a supersaturation of metal atoms around the metal droplets leading to nucleation and growth of the nanoparticles. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 18/549634 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 1/142 (20220101) B22F 9/12 (20130101) Original (OR) Class B22F 2202/01 (20130101) B22F 2202/05 (20130101) B22F 2202/07 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 25/00 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/0045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157634 | Arriaga et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rodrigo Telles Arriaga (San Francisco, California); Caitlyn Christian Krikorian (Livermore, California); Elaine Lee (Moraga, California); Jennifer Lewis (Boston, Massachusetts) |
| ABSTRACT | A product includes a three-dimensional structure having a plurality of sequentially-formed layers comprised of liquid crystal elastomers. The liquid crystal elastomers in at least a predefined portion of a first of the layers are substantially aligned in a first orientation, and the liquid crystal elastomers in at least a predefined portion of a second of the layers are substantially aligned in a second orientation. In addition, each of the portions of the three-dimensional structure is characterized as exhibiting a shape change in response to a stimulus, where the shape change is reversible. |
| FILED | Monday, June 19, 2023 |
| APPL NO | 18/211514 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/188 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2021/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158223 | Walton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John PK Walton (Troy, Ohio); LaVern A. Starman (Dayton, Ohio); David Torres Reyes (Springboro, Ohio) |
| ABSTRACT | An actuator element of a MEMS device on a substrate able to create large, out-of-plane deflection includes two separated metallic layers contacting the substrate. The second metallic layer has a first portion contacting the substrate and a second portion having cantilevered over the substrate and first metallic layer. A first insulating layer contacts the cantilevered metallic layer on a bottom contacting surface and a second insulating layer contacting the cantilevered metallic layer on a portion of a top contacting surface. The second, cantilevered portion of the metallic layer is prestressed causing the distal end to deform away from the substrate. Applying a voltage potential between the first and second metallic layers creates an electrostatic field drawing the distal end toward the substrate. |
| FILED | Wednesday, January 24, 2024 |
| APPL NO | 18/421596 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0043 (20130101) Original (OR) Class B81B 2201/032 (20130101) B81B 2201/042 (20130101) B81B 2203/053 (20130101) B81B 2203/058 (20130101) Optical Elements, Systems, or Apparatus G02B 26/0833 (20130101) G02B 26/0841 (20130101) G02B 26/0866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158449 | Flynn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Flynn (Pasadena, California); Michael B. Elowitz (Pasadena, California); Acacia Hori (Pasadena, California); Viviana Gradinaru (La Canada Flintridge, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for robust and tunable control of payload gene expression. Some embodiments provide rationally designed circuits, including miRNA-level and/or protein-level incoherent feed-forward loop circuits, that maintain the expression of a payload at an efficacious level. The circuit can comprise a promoter operably linked to a polynucleotide encoding a fusion protein comprising a payload protein, a protease, and one or more self-cleaving peptide sequences. The payload protein can comprise a degron and a cut site the protease is capable of cutting to expose the degron. The circuit can comprise a promoter operably linked to a polynucleotide comprising a payload gene, a silencer effector cassette, and one or more silencer effector binding sequences. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/480851 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158658 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinsong Huang (Chapel Hill, North Carolina); Shangshang Chen (Chapel Hill, North Carolina) |
| ABSTRACT | Described herein are oxidative-resistant ink solutions, comprising: a first composition of formula ABI3-yXy; one or more solvents; and a compound of Formula (II), or a salt thereof, wherein A, B, y, and X are described herein. Methods for preparing perovskite films using the oxidative-resistant ink solutions and the use of the films in solar cells and solar modules are additionally described. In certain embodiments, further described are methods of preparing perovskite films having reduced interfacial voids, comprising adding a compound of Formula (II), or a salt thereof, to the perovskite precursor solution used to prepare the film. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 18/270383 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/033 (20130101) C09D 11/037 (20130101) C09D 11/52 (20130101) Original (OR) Class Organic electric solid-state devices H10K 71/13 (20230201) H10K 85/50 (20230201) H10K 85/60 (20230201) H10K 85/655 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158743 | Amini |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trailhead Biosystems Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nooshin Amini (Cleveland, Ohio) |
| ABSTRACT | Methods for generating pre-oligodendrocyte progenitor cells (pre-OPCs) and oligodendrocyte progenitor cells (OPCs) from human pluripotent stem cells are provided using chemically-defined culture media that allow for generation of pre-OPCs and OPCs in as little as three days. Culture media, isolated cell populations and kits are also provided. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/422961 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 2501/41 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2533/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158744 | AMINI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trailhead Biosystems Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nooshin AMINI (Cleveland, Ohio) |
| ABSTRACT | Methods for generating pre-oligodendrocyte progenitor cells (pre-OPCs) and oligodendrocyte progenitor cells (OPCs) from human pluripotent stem cells are provided using chemically-defined culture media that allow for generation of pre-OPCs and OPCs in as little as three days. Culture media, isolated cell populations and kits are also provided. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/423155 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 2501/41 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2533/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158748 | Better et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kite Pharma, Inc. (Santa Monica, California); The United States of America, as represented by the Secretary, Department of Health and Human Serv (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc Better (Santa Monica, California); Steven A. Feldman (Bethesda, Maryland); Steven A. Rosenberg (Bethesda, Maryland) |
| ABSTRACT | Provided herein are methods for manufacturing T cells. In certain embodiments, methods for manufacturing T cells which express a cell surface receptor that recognizes a specific antigenic moiety on the surface of a target cell are provided. Also provided herein are populations of engineered T cells produced by the methods described herein and pharmaceutical compositions thereof. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/393414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/1774 (20130101) A61K 39/0011 (20130101) A61K 39/39558 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Peptides C07K 14/7051 (20130101) C07K 16/2896 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 2500/90 (20130101) C12N 2501/515 (20130101) C12N 2501/2302 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158774 | SIEGEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin Bloomfield SIEGEL (Seattle, Washington); David BAKER (Seattle, Washington); Ingrid Swanson PULTZ (Seattle, Washington) |
| ABSTRACT | The invention provides compositions and methods for treating celiac sprue. |
| FILED | Monday, July 24, 2023 |
| APPL NO | 18/357617 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Original (OR) Class C12N 9/64 (20130101) C12N 9/6489 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158776 | FU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinglin FU (Tempe, Arizona); Zhao ZHAO (Boston, Massachusetts); Neal WOODBURY (Tempe, Arizona); Hao YAN (Chandler, Arizona) |
| ABSTRACT | The present disclosure describes a nanoparticle comprising a three dimensional DNA nanocage and a payload biological macromolecule, and methods of assembly thereof. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/481955 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) Original (OR) Class C12N 11/06 (20130101) C12N 11/10 (20130101) C12N 15/11 (20130101) C12N 2310/532 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158807 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (CORK, Ireland) |
| ABSTRACT | Circular RNA and methods and constructs for engineering circular RNA are disclosed. In some embodiments, the circular RNA includes the following elements arranged in the following sequence: a) a 3′ Group I self-splicing intron fragment, b) an internal ribosome entry site (IRES), c) a protein coding region or noncoding region, and d) a 5′ Group I self-splicing intron fragment. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/544160 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158863 | KASSIS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Amin I. KASSIS (Chestnut Hill, Massachusetts) |
| ABSTRACT | Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having cancer are also provided. Methods and compositions for diagnosing the presence of an infectious agent in an individual and/or for identifying an infectious agent-specific signature in an infected individual are provided. Methods and compositions for diagnosing the presence of a disease in an individual are also provided. Methods and compositions for identifying a disease-specific signature in an individual having the disease are also provided. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/210213 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/569 (20130101) G01N 33/5023 (20130101) G01N 33/5047 (20130101) G01N 33/5052 (20130101) G01N 33/5055 (20130101) G01N 33/5091 (20130101) G01N 33/57407 (20130101) G01N 33/57434 (20130101) G01N 33/57449 (20130101) G01N 33/57484 (20130101) G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158864 | Berchuck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Berchuck (Brookline, Massachusetts); Matthew Freedman (Needham, Massachusetts); Sylvan Baca (Brookline, Massachusetts) |
| ABSTRACT | Methods and compositions are provided for detecting the presence of neuroendocrine prostate cancer in a subject by analyzing DNA methylomes. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/272184 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158899 | Beura et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); DEVCOM Army Research Laboratory (Aberdeen, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vikrant Beura (Tempe, Arizona); Kiran Solanki (Tempe, Arizona); Kris Darling (Aberdeen, Maryland) |
| ABSTRACT | The present invention relates to surface attrition treatment, compositions, and methods of use thereof. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/388317 |
| CURRENT CPC | Abrasive or Related Blasting With Particulate Material B24C 1/10 (20130101) Alloys C22C 21/00 (20130101) C22C 21/02 (20130101) C22C 21/14 (20130101) C22C 21/16 (20130101) C22C 30/02 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/04 (20130101) C22F 1/16 (20130101) C22F 1/043 (20130101) C22F 1/057 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159145 | Trivedi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deepak Trivedi (Halfmoon, New York); Yew Teck Tan (Schenectady, New York); Emad A. Andarawis (Ballston Lake, New York) |
| ABSTRACT | A system for use in navigating and/or forming a tunnel includes a tunneling device including a body assembly and a fluid line coupled to the body assembly. The body assembly includes a first section and a second section that are configured to selectively adjust their size and move the body assembly through an underground location when a pressurized fluid is delivered to the body assembly through the fluid line. The system further includes at least one sensor coupled to the body assembly and/or the fluid line. The at least one sensor is configured to provide information related to an operating parameter of at least one of the first section of the body assembly or the second section of the body assembly. The system also includes a controller configured to determine an environmental characteristic of the tunnel based on the information provided by the at least one sensor. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/981945 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 7/26 (20130101) E21B 7/30 (20130101) Original (OR) Class E21B 49/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159198 | ECKROTH |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | Cummins Inc. (Columbus, Indiana); Achates Power, Inc. (San Diego, California) |
| INVENTOR(S) | David J. ECKROTH (Columbus, Indiana) |
| ABSTRACT | An internal combustion engine with an engine block with at least one cylinder cavity housing a cylinder liner. The cylinder liner includes at least one aperture in a wall of the cylinder liner that is aligned with one of an intake port or an exhaust port in the engine block. |
| FILED | Wednesday, August 02, 2023 |
| APPL NO | 18/364001 |
| CURRENT CPC | Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 1/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159247 | JOLY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael M. JOLY (Hebron, Connecticut); Joseph KATZ (Farmington, Connecticut) |
| ABSTRACT | Compressor sections of gas turbine engines include a casing, a rotor arranged within with casing, the rotor having a plurality of blades that are rotatable relative to the casing, and a casing treatment applied to the casing. The casing treatment includes a plurality of covered channels each having an inlet and an outlet and a partially covered cavity defined between the inlet and the outlet in an axial direction and between a cover wall and a casing wall in a radial direction relative to an axis through the casing. A core flow through the casing is in a core flow direction and a recirculation flow through the plurality of covered channels is in a recirculation flow direction, the recirculation flow direction being counter to the core flow direction, and the inlet is at a position downstream relative to the outlet in the core flow direction. |
| FILED | Monday, May 15, 2023 |
| APPL NO | 18/197429 |
| CURRENT CPC | Non-positive-displacement Pumps F04D 27/0238 (20130101) F04D 29/526 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/14 (20130101) F05D 2250/75 (20130101) F05D 2260/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159592 | MORRIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Science Applicaions International Corporation (Reston, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David M. MORRIS (Bloomington, Indiana); John P. TIMLER (River ridge, Louisiana) |
| ABSTRACT | Infrared transparent constructs (e.g., infrared transparent windows) may be shaped as a dome (e.g., for an infrared detector system) and/or other desired geometries, such as portions of IR seeker domes. Electrically conductive tracing(s) may be printed in desired shapes and forms, e.g., in the form of EMI shielding, an FSS grid, an anti-static component, electrical connectors, etc., and integrated into the interior of the construct structure. The electrically conductive tracing(s) may be printed between layers of independent infrared transparent window components that are then engaged together to form a window preform. Additionally or alternatively, the electrically conductive tracing(s) may be printed between printed layers of infrared transparent ceramic or plastic material built up to form the window preform. Once formed, the window preform may be sintered, e.g., in an ultrafast high temperature sintering process (and optionally further treated) to produce the final infrared transparent construct. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/510897 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0875 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159676 | JACOB et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zubin JACOB (West Lafayette, Indiana); Hyunsoo CHOI (West Lafayette, Indiana); Fanglin BAO (West Lafayette, Indiana); Adrian Ezequiel RUBIO LOPEZ (Santiago, Chile) |
| ABSTRACT | Imaging systems and methods are disclosed for detecting objects in low photon environments. Embodiments modulate separate groups of photons from the same source, modulate the wavefronts of the separate groups of photons, recombine the modulated photons, utilize information of the recombined photons (such as by utilizing pre-trained reinforcement learning networks and/or by using the Fisher information), and iteratively adjust the manner in which the wavefronts are modulated to detect objects in the sub-Rayleigh region, and in dim regions with a small number of photons, for example, on the order of 10,000 per second or less. Further embodiments determine the iterative modulation patterns utilizing pre-trained reinforcement learning networks. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508835 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159765 | Walt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts) |
| INVENTOR(S) | David R. Walt (Boston, Massachusetts); David M. Rissin (Lexington, Massachusetts) |
| ABSTRACT | Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection and quantitation. |
| FILED | Wednesday, November 22, 2023 |
| APPL NO | 18/518117 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) G01N 33/581 (20130101) Original (OR) Class G01N 33/54346 (20130101) G01N 33/54366 (20130101) G01N 33/54386 (20130101) G01N 2333/938 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159766 | CLINTON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| ASSIGNEE(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| INVENTOR(S) | Charles M. CLINTON (Clarksburg, Maryland); Eli N. GLEZER (Chevy Chase, Maryland); Bandele JEFFREY-COKER (Darnestown, Maryland); Sandor L. KOVACS (Middletown, Maryland); Sudeep M. KUMAR (Gaithersburg, Maryland); George SIGAL (Rockville, Maryland); Carl STEVENS (Silver Spring, Maryland); Michael VOCK (Loveland, Ohio) |
| ABSTRACT | We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545200 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 3/50255 (20130101) Applying Closure Members to Bottles Jars, or Similar Containers; Opening Closed Containers B67B 7/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/66 (20130101) G01N 21/6452 (20130101) G01N 33/582 (20130101) Original (OR) Class G01N 33/5302 (20130101) G01N 35/028 (20130101) G01N 35/109 (20130101) G01N 35/1002 (20130101) G01N 35/1011 (20130101) G01N 35/1079 (20130101) G01N 35/1081 (20130101) G01N 2035/0405 (20130101) Technical Subjects Covered by Former US Classification Y10T 83/9314 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159784 | Collins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Nathan Collins (San Mateo, California); Jeremiah Malerich (San Jose, California); Jason D. White (San Jose, California); Kevin Luebke (Staunton, Virginia); Kristina Rucker (Menlo Park, California); Brian McCoy (San Jose, California) |
| ABSTRACT | Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/389930 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/00344 (20130101) B01J 2219/00351 (20130101) B01J 2219/00495 (20130101) B01J 2219/00689 (20130101) B01J 2219/00693 (20130101) B01J 2219/00695 (20130101) B01J 2219/00698 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/04 (20130101) G01N 35/00613 (20130101) Original (OR) Class G01N 35/00871 (20130101) G01N 35/1002 (20130101) G01N 2035/00346 (20130101) G01N 2035/0403 (20130101) G01N 2035/0496 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 10/00 (20190201) G16C 20/10 (20190201) G16C 20/70 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159942 | Gopinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Juliet T. Gopinath (Boulder, Colorado); Samuel D. Gilinsky (Boulder, Colorado); Mo Zohrabi (Longmont, Colorado); Victor M. Bright (Boulder, Colorado); Omkar D. Supekar (Painted Post, New York); Wei Yang Lim (Eden Prairie, Minnesota) |
| ABSTRACT | A microlens array includes a bottom electrode chip, a sidewall electrode chip, and a top glass chip configured to cooperate to define an array of cavities, each one of the array of cavities containing a fluid. The fluid is a mixture of a polar liquid and a non-polar liquid, in contact with one of the array of sidewalls at a contact angle. The bottom electrode chip includes a plurality of electrical contacts. The sidewall electrode chip includes an array of sidewalls, each including an electrode layer and an insulator layer. When a voltage is applied across the fluid contained a cavity via electrical contacts and the electrode layer of the cavity, the contact angle of the fluid with the sidewall is modified, in embodiments without affecting the contact angle of fluid contained in other ones of the plurality of array of cavities. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/508114 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/14 (20130101) G02B 3/0056 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/294 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160001 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Kwan Kit Lee (Tucson, Arizona); Michael Grace (Tucson, Arizona); Amit Ashok (Tucson, Arizona); Saikat Guha (Tucson, Arizona) |
| ABSTRACT | Imaging a distribution of one or more optical sources includes: receiving respective optical signals from a spatial mode sorter during each of two or more detection intervals of time; after each of the two or more detection intervals of time, processing information based at least in part on: (1) the respective optical signal received in the corresponding detection interval of time, and (2) a first set of models comprising a set of distributions related to one or more optical sources, each model corresponding to a different number of optical sources in the distribution, and configuring the spatial mode sorter based at least in part on the processing; and providing an estimated measurement characterizing the distribution of one or more optical sources based at least in part on the processed information. The processing after at least one of the two or more detection intervals of time includes computing an eigen-projection. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/289232 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/361 (20130101) Original (OR) Class G02B 27/58 (20130101) Computer Systems Based on Specific Computational Models G06N 7/01 (20230101) G06N 10/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160666 | EKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ADVANCED MICRO DEVICES, INC. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ALI ARDA EKER (BELLEVUE, Washington); ANTHONY T. GUTIERREZ (BELLEVUE, Washington) |
| ABSTRACT | A system includes a processor configured to iteratively, until values of a frontier vector indicate all nodes of a graph have been discovered, select a set of rows from a matrix representation of the graph based on values of the frontier vector. The set of rows includes fewer rows than the matrix representation. The processor is further configured to calculate an output vector for a current iteration as a dot product between each of the selected set of rows in the matrix representation and the frontier vector, with the output vector for the current iteration acting as the frontier vector for a next iteration and the output vector for the next iteration initialized to the frontier vector for the current iteration. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/985136 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/9024 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160903 | Fouse et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aptima, Inc. (Woburn, Massachusetts) |
| ASSIGNEE(S) | Aptima, Inc. (Woburn, Massachusetts) |
| INVENTOR(S) | Adam Fouse (Medford, Massachusetts); Ryan Mullins (Somerville, Massachusetts); Patrick Cummings (Reading, Massachusetts); Manuel Moquete (Methuen, Massachusetts); Nathan Schurr (Poway, California); John Feeney (Beavercreek, Ohio); Chad Weiss (Beavercreek, Ohio) |
| ABSTRACT | Disclosed are systems and methods of communicating an attribute of an artificial intelligence (AI) agent system through an interface. The methods comprise receiving input data, determining attribute values of attributes to the input data over temporal periods, determining interface attribute values representing the interface attributes and communicating the interface attribute values to a dynamic interface. Also disclosed is a contextualized system comprising a contextualizer module and a user interface configured to communicate a recommended data to a user. In some embodiments, the contextualizer module selects a most pertinent data as the recommended data based on an activity of the user. |
| FILED | Tuesday, August 15, 2023 |
| APPL NO | 18/450277 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0475 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160907 | Rietman et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Rietman (Boston, Massachusetts); Hava Siegelmann (Boston, Massachusetts) |
| ABSTRACT | Various examples are provided related to quantum reservoir neural network processing including machine learning with correlated quantum matter and use of correlated quantum matter as a physical unclonable function (PUF). In one example, a quantum reservoir neural network processor includes a structure including correlated quantum matter; input electrodes that can apply input signals; output electrodes that can provide an output signal generated in response to the input signals and a control signal applied to the structure; and processing circuitry that can receive the output signal and provide the control signal. The processing circuitry can identify an input corresponding to the input signals based upon the output signal. In another example, a PUF includes correlated quantum matter; at least one input electrode disposed on a first side of the correlated quantum matter; and an output electrode disposed on a second side of the correlated quantum matter opposite the first side. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200276 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Original (OR) Class G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160924 | Rackauckas et al. |
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| FUNDED BY |
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| APPLICANT(S) | JuliaHub, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Rackauckas (Cambridge, Massachusetts); Anas Abdelrehim (Toronto, Canada); Ranjan Anantharaman (Newton, Massachusetts) |
| ABSTRACT | Methods and computer systems for improving automated surrogate training performance on specific applications by incorporating simulator information into the learnable architecture are disclosed. They allow for a chosen architecture to more closely resemble the system being modeled, which allows the chosen architecture to do so more efficiently, in terms of computational efficiency as well as amount of training data required, and more accurately. A prior analysis of the system being modeled is performed, either before the training phase or during the training phase as modifications to the loss function, to determine one or more mathematical properties that have clear ways of being baked into the architecture, for example by scaling a reservoir of the surrogate to the proper time scale for the system being modeled. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/424281 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160944 | Masse et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolas Y. Masse (Cambridge, Massachusetts); David J. Freedman (Chicago, Illinois); Matthew C. Rosen (Chicago, Illinois) |
| ABSTRACT | A method includes selecting artificial neural network parameters; sampling the parameters; selecting connection weights; initializing the artificial neural networks; running the artificial neural networks on cognitive tasks; and determining whether activity is within an acceptable range. A computing system includes a processor; and a memory having stored thereon computer-executable instructions that, when executed by the one or more processors, cause the computing system to select artificial neural network parameters; sample the parameters; select connection weights; initialize the artificial neural networks; run the artificial neural networks on cognitive tasks; and determine whether activity is within an acceptable range. A non-transitory computer-readable medium containing program instructions that when executed, cause a computer to select artificial neural network parameters; sample the parameters; select connection weights; initialize the artificial neural networks; run the artificial neural networks on cognitive tasks; and determine whether activity is within an acceptable range. |
| FILED | Friday, April 21, 2023 |
| APPL NO | 18/138015 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/092 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161232 | AKBARPOUR et al. |
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| FUNDED BY |
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| APPLICANT(S) | Hadi Ali AKBARPOUR (Columbia, Missouri); Kannappan PALANIAPPAN (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hadi Ali AKBARPOUR (Columbia, Missouri); Kannappan PALANIAPPAN (Columbia, Missouri) |
| ABSTRACT | A method is provided for using Light-Field Dynamic Homography (DH) to generate a large virtual focal plane from a non-rigid camera array with narrow overlaps between their fields of view (FOV). The method incorporates the 3D geometry of the cameras and employs non-linear least square optimization to dynamically estimate the inter-view homography transformations. Remarkably, only two feature correspondences are required between adjacent views to stitch the images and generate a wide virtual focal plane array, eliminating the need for significant FOV overlaps between the multiple cameras. |
| FILED | Friday, June 09, 2023 |
| APPL NO | 18/332546 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4038 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 23/80 (20230101) H04N 23/90 (20230101) H04N 23/698 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161301 | Madabhushi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Nathaniel Braman (Cleveland, Ohio); Vidya Sankar Viswanathan (Shaker Heights, Ohio) |
| ABSTRACT | The present disclosure relates to a method. The method includes accessing data having one or more segmented images identifying one or more lesions and/or a plurality of blood vessels associated with the lesions. Respective ones of the blood vessels correspond to one or more centerlines and one or more constituent branches associated with the one or more lesions. The one or more segmented images are derived from one or more radiological images of a patient having cancer. One or more vascular radiology features are extracted using the centerlines, the constituent branches, and the one or more lesions. The one or more vascular radiology features relate to a quantification of the plurality of blood vessels or a shape of the plurality of blood vessels. The one or more vascular radiology features are used to determine a medical prediction associated with an outcome of the patient to cyclin-dependent kinase (CDK) inhibitor therapy. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500473 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0016 (20130101) Original (OR) Class G06T 2207/10116 (20130101) G06T 2207/30056 (20130101) G06T 2207/30068 (20130101) G06T 2207/30096 (20130101) G06T 2207/30101 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161733 | Tran et al. |
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| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ngoc Minh Tran (Dublin, Ireland); Hessel Tuinhof (Dublin, Ireland); Beat Buesser (Dublin, Ireland) |
| ABSTRACT | A method, computer program product, and computer system for generation of training examples for training an automatic speech recognizer. Embodiments of the present invention can receive a training dataset of original audio signals and generate training examples for training an automatic speech recognizer based, at least in part, on a constructed imperceptible space for an original audio signal of the original audio signals and adversarial audio examples in the constructed imperceptible space. Embodiments of the present invention can then generate an imperceptible and adversarial audio example to an adversarial trainer for the automatic speech recognizer. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 18/054670 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/01 (20130101) G10L 15/063 (20130101) Original (OR) Class G10L 15/065 (20130101) G10L 25/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161926 | Krebs et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); Wisconsin Alumni Research Foundation (Madison, Wisconsin); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Olivia Krebs (Cleveland Heights, Ohio); Pallavi Tiwari (Waunakee, Wisconsin); Germán Corredor (Beachwood, Ohio) |
| ABSTRACT | The present disclosure relates to a method. The method includes accessing a segmented digitized pathology image corresponding to a high grade glioma (HGG) patient having a first biological sex. The segmented digitized pathology image identifies nuclei. The nuclei are classified as tumor infiltrating lymphocytes (TILs) or non-TILs. Sex specific features related to the nuclei identified as the TILs and the non-TILs are extracted. The sex specific features characterize a spatial organization of the TILs and the non-TILs. The sex specific features are operated on with a sex specific machine learning model corresponding to the first biological sex to generate a sex specific patient risk score. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/493862 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/00 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162028 | KIM et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jungsang KIM (Chapel Hill, North Carolina); Kai HUDEK (Durham, North Carolina); Geert VRIJSEN (Durham, North Carolina); Robert SPIVEY (Durham, North Carolina); Peter MAUNZ (Durham, North Carolina) |
| ABSTRACT | A package-level, integrated high-vacuum ion-chip enclosure having improved thermal characteristics is disclosed. Enclosures in accordance with the present invention include first and second chambers that are located on opposite sides of a chip carrier, where the chambers are fluidically coupled via a conduit through the chip carrier. The ion trap is located in the first chamber and disposed on the chip carrier. A source for generating an atomic flux is located in the second chamber. The separation of the source and ion trap in different chambers affords thermal isolation between them, while the conduit between the chambers enables the ion trap to receive the atomic flux. |
| FILED | Tuesday, July 18, 2023 |
| APPL NO | 18/223246 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Electric Discharge Tubes or Discharge Lamps H01J 49/16 (20130101) H01J 49/24 (20130101) H01J 49/42 (20130101) H01J 49/422 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162112 | Venkatasubramanian et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Rama Venkatasubramanian (Cary, North Carolina); Jonathan M. Pierce (Eldersburg, Maryland); Dezsi Geza (Durham, North Carolina) |
| ABSTRACT | Example superlattice structures and methods for thermoelectric devices are provided. An example structure may include a plurality of superlattice periods. Each superlattice period may include a first material layer disposed adjacent to a second material layer. For each superlattice period, the first material layer may be formed of a first material and the second material layer may be formed of a second material. The plurality of superlattice periods may include a first superlattice period and a second superlattice period. A thickness of a first material layer of the first superlattice period may be different than a thickness of a first material layer of the second superlattice period. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/423362 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/38 (20130101) Original (OR) Class H01L 33/645 (20130101) Electric solid-state devices not otherwise provided for H10N 10/01 (20230201) H10N 10/13 (20230201) H10N 10/17 (20230201) H10N 10/81 (20230201) H10N 10/852 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162341 | Tahhan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Maher Bishara Tahhan (Tewksbury, Massachusetts); John Andrew Logan (Lawrence, Massachusetts) |
| ABSTRACT | A high electron mobility heterostructure and a method of fabricating the heterostructure, wherein the high electron mobility heterostructure comprises a substrate, a buffer on the substrate, a doped charge compensation layer on the buffer, a double continuous grade barrier on the doped charge compensation layer having increasing polarization charge and decreasing polarization charge, a channel on the double continuous grade barrier, and a charge generation layer on the channel. The method comprises forming a substrate, forming a buffer on the substrate, forming a doped charge compensation layer on the buffer, forming a double continuous grade barrier on the doped charge compensation layer, forming a channel on the double continuous grade barrier, and forming a charge generation layer on the channel. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 18/054990 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/0254 (20130101) H01L 21/02376 (20130101) H01L 21/02378 (20130101) H01L 21/02381 (20130101) H01L 21/02389 (20130101) H01L 21/02458 (20130101) H01L 21/02576 (20130101) H01L 21/02579 (20130101) H01L 29/205 (20130101) H01L 29/207 (20130101) H01L 29/2003 (20130101) H01L 29/7787 (20130101) Original (OR) Class H01L 29/66462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162374 | EFROS et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the Unites States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander L. EFROS (Annandale, Virginia); Michael SHUR (Troy, New York) |
| ABSTRACT | An optoelectronic device comprising at least one quantum wire and at least one quantum dot (QD) incorporated in the quantum wire with the band gap of the quantum wire being larger than the band gap of the quantum dot. The QDs and QD arrays are embedded in various quantum wires, thus providing higher yields in optoelectronic devices, such as light emitting diodes, lasers, and photodetectors. This is achieved by a nearly complete suppression of the nonradiative Auger recombination and enhancement of the light extraction efficiency. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535259 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) Original (OR) Class H01L 33/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162620 | Cavallo et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| INVENTOR(S) | Francesca Cavallo (Albuquerque, New Mexico); Divya Prakash (Albuquerque, New Mexico); Daniel W. van der Weide (Albuquerque, New Mexico); Max G. Lagally (Albuquerque, New Mexico); Shiva Hajitabarmarznaki (Albuquerque, New Mexico); Shelley S. Scott (Albuquerque, New Mexico) |
| ABSTRACT | An antenna comprising: input and output coaxial horn antennas coupled with a self-assembled helical slow-wave structure cradled in a groove in a silicon-on-insulator wafer. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/508172 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/38 (20130101) H01Q 11/08 (20130101) Original (OR) Class H01Q 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162759 | Davlantes et al. |
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| FUNDED BY |
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| APPLICANT(S) | Reach Power, Inc. (Redwood City, California) |
| ASSIGNEE(S) | Reach Power, Inc. (Redwood City, California) |
| INVENTOR(S) | Christopher Joseph Davlantes (Emeryville, California); Varun Ramaswamy (Emeryville, California) |
| ABSTRACT | A system for wireless power networking, preferably including one or more nodes, such as transmit nodes, receive nodes, relay nodes, and/or hybrid nodes. The system may function to form a power network (e.g., mesh network) configured to transfer power wirelessly between nodes of the system. A method for wireless power networking, preferably including transmitting power, controlling relay nodes, and/or receiving power, and optionally including optimizing power network operation. The method is preferably performed at (e.g., by one or more nodes of) the system, but can additionally or alternatively be performed by any other suitable system(s). |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/424294 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/005 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/23 (20160201) Original (OR) Class H02J 50/50 (20160201) Transmission H04B 7/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162942 | Zheng et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lehigh University (Bethlehem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yahong Rosa Zheng (Bethlehem, Pennsylvania); Xiyuan Zhu (Bethlehem, Pennsylvania) |
| ABSTRACT | An acoustic transmission device may communicate sensing data via one or more multiple-input multiple-output (MIMO) transmissions. The device may comprise a serial peripheral interface (SPI) and/or a phase shifting key (PSK) modulator. The device may be configured to provide a first SPI signal, perhaps including one or more coded information bits, to the PSK modulator. The device may provide a second SPI signal, perhaps including a synchronous clock signal, to the PSK modulator. The device may generate of one or more symbols on N transmit branches based on the first SPI signal. The device may generate of at least one carrier frequency with one or more phases to form one or more phased carriers based on the second SPI signal. The device may control a transmission of the sensing data (e.g., video) via the one or more symbols on the N transmit branches on the one or more phased carriers. |
| FILED | Friday, May 05, 2023 |
| APPL NO | 18/143839 |
| CURRENT CPC | Transmission H04B 7/0413 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 27/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162998 | Vogel et al. |
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| FUNDED BY |
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| APPLICANT(S) | Systems and Technology Research, LLC (Woburn, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Vogel (Lynnfield, Massachusetts); Evan D. Walsh (Billerica, Massachusetts) |
| ABSTRACT | A method of clock synchronization for a distributed, message-passing network includes the step of dissecting a graphical model of the distributed network into a sequence of time-varying directed sub-graphs, each sub-graph including a selection of closed loops. By comparing the sequence of sub-graphs, the influence of each closed loop is quantified. Using the loop influence information, a selection of edges in the graphical model is dynamically identified for deletion using a hierarchically semiseparable structure in order to yield an optimized graphical model. A sum-product message-passing algorithm is then applied to the optimized graphical model to calculate a clock synchronization solution. By maintaining an optimal subset of closed loops within the model, the algorithm converges to a synchronization solution, while, at the same time, limits susceptibility to faults as well as maintains a sufficient degree of algorithmic complexity that streamlines the number of steps required to achieve convergence. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/572936 |
| CURRENT CPC | Multiplex Communication H04J 3/0638 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162999 | Bedrosian |
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| FUNDED BY |
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| APPLICANT(S) | MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | P. Stephan Bedrosian (McLean, Virginia) |
| ABSTRACT | A range is determined between two unsynchronized communications terminals in which a first terminal transmits a range request to a second terminal. The first terminal stores a first timestamp in memory corresponding to a time at which the range request message was transmitted. A range response is later received by the first terminal from the second terminal. The range response includes a residence time that characterizes an amount of time the second terminal required to send the range response after receiving the range request. The first terminal later stores a second timestamp in memory corresponding to a time at which the range response was received. Based on the second timestamp minus the first timestamp and the residence time, a roundtrip time for the range request is calculated. This roundtrip time can be used to calculate a distance between the first terminal and the second terminal based on the roundtrip time. |
| FILED | Wednesday, January 24, 2024 |
| APPL NO | 18/421093 |
| CURRENT CPC | Multiplex Communication H04J 3/0661 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 43/0864 (20130101) Wireless Communication Networks H04W 56/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240163078 | Eldefrawy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karim Eldefrawy (Palo Alto, California); Nicholas James Genise (San Mateo, California) |
| ABSTRACT | An attribute based encryption system includes a key generator configured to generate a cyclic group (G) having a prime order q; generate an attribute key matrix (M); generate a master public key (MPK) based, at least in part, on the group (G) and (M); generate a master secret key (MSK) based on a first vector s and a second vector t that represent an encryption policy; generate a user secret key based, at least in part, on the MSK and on a set of one or more user attributes; and send the user secret key to a user device, wherein a ciphertext message can be successfully decrypted if a vector y associated with attributes of the user associated with the user secret key is orthogonal to each row of a set of rows of M selected according to a set of authorization attributes used to encrypt the ciphertext message. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 18/548776 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0618 (20130101) Original (OR) Class H04L 9/3066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240163155 | Abdellatif et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hussam Abdellatif (Boston, Massachusetts); Paboda Viduneth Ariyarathna Beruwawela Pathiranage (San Diego, California); Habarakada Liyanachchi Prabath Arjuna Madanayake (West Miami, Florida); Josep Miquel Jornet (Needham, Massachusetts) |
| ABSTRACT | A system and corresponding method may be employed for real-time ultrabroadband wireless communications. The system comprised a plurality of in-phase and quadrature (IQ) mixers that produce, in real-time on a per-channel basis, sub-channel signals from respective analog baseband IQ signals representing respective portions of user data. The system further comprises a power combiner. The power combiner produces a multi-channel output signal by frequency multiplexing, in real-time, the sub-channel signals produced. The multi-channel output signal represents the user data in its entirety and may be a real-time, multi-GHz wireless signal. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/412451 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 27/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240163565 | BYCROFT et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Benjamen P. BYCROFT (Los Angeles, California); Donald Wayne DENHAM (Arlington, Virginia) |
| ABSTRACT | Zoned anti-glint filtering includes identifying one or more pixels impacted or predicted to be impacted by glint in a captured image, and adjusting the one or more pixels to capture an image with those zones dimmed to mitigate impacts from glint. Knowledge of the applied anti-glint filter may be used in post-processing to reconstruct an image without adverse impacts from glint or the anti-glint filtering process. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 18/055328 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 5/2351 (20130101) H04N 5/2352 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240164006 | Raman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chandra Raman (Atlanta, Georgia); Yorick Andeweg (Atlanta, Georgia); Alexandra Crawford (Atlanta, Georgia); Chao Li (Atlanta, Georgia); Bochao Wei (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a collimated atomic beam generator. The generator can comprise an atomic vapor chamber, a collimator plate, and an insulative adhesive layer. The atomic vapor chamber can comprise an atomic vapor source. The collimator plate can comprise a first side facing the atomic vapor chamber, an opposing second side, and a plurality of channels extending between the first side and the second side. The insulative adhesive layer can be positioned between and coupling the atomic vapor chamber to the collimator plate. The collimator plate can be configured to collimate atomic vapors generated by the atomic vapor source in the atomic vapor chamber. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/162959 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 3/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240156743 | Scott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan A. Scott (Evanston, Illinois); Fanfan Du (Evanston, Illinois); Baofu Qiao (Evanston, Illinois); Monica Olvera de la Cruz (Evanston, Illinois) |
| ABSTRACT | The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472901 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) A61K 9/5146 (20130101) Original (OR) Class A61K 9/5192 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156964 | Zakrewsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Triad National Security, LLC (Los Alamos, New Mexico); The Arizona Board of Regents (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Zakrewsky (San Diego, California); Samir Mitragotri (Lexington, Massachusetts); David T. Fox (Los Alamos, New Mexico); Andrew Koppisch (Flagstaff, Arizona); Rico Del Sesto (Ivins, Utah); Katherine Lovejoy (Silver Spring, Maryland) |
| ABSTRACT | The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472966 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 33/12 (20130101) A01N 43/36 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/047 (20130101) A61K 31/66 (20130101) A61K 31/545 (20130101) A61K 47/12 (20130101) A61K 47/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156996 | Davern et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sandra M. Davern (Knoxville, Tennessee); Miguel Toro Gonzalez (Knoxville, Tennessee); Ilja Popovs (Knoxville, Tennessee); Santa Jansone-Popova (Knoxville, Tennessee) |
| ABSTRACT | A biocompatible radionuclide-containing composition comprising: (i) a radionuclide-containing core, which includes complexed or uncomplexed radionuclide atoms; and (ii) a carrier encapsulating the radionuclide-containing core, wherein the carrier may be attached to a targeting moiety that can selectively transport the composition to a specific cell type when introduced into an organism, or the carrier may be attached to a moiety that evades an immune system of an organism. Also described is a method of treating cancer in a subject by administering to the subject a pharmaceutically effective amount of the composition described above. Also described is a method of treating an infection in a subject by administering to the subject a pharmaceutically effective amount of the composition described above. Also described is a method of imaging biological tissue in a subject by administering the composition to the subject and imaging biological tissue in the subject by a nuclear medicine imaging technique. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/385428 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 51/0455 (20130101) Original (OR) Class A61K 2121/00 (20130101) A61K 2123/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157273 | Brown |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Michael Alexander Brown (Chicago, Illinois) |
| ABSTRACT | The invention provides a method for generating a daughter isotope, the method comprising contacting an ion exchange column with parent isotope; allowing the column to equilibrate between the parent and daughter isotopes; eluting the daughter isotope from the column; and repeating the equilibration and elution steps. Also provided is a system for repeatedly generating isotopes from the same support column over time with a single loading of parent isotope, the system comprising a radiation-resistant sorbent column; a parent isotope permanently contained within the column; and a fluid to elute daughter isotope from the column. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/987680 |
| CURRENT CPC | Separation B01D 15/22 (20130101) B01D 15/361 (20130101) Original (OR) Class B01D 15/426 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 13/00 (20130101) Conversion of Chemical Elements; Radioactive Sources G21G 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157338 | SADOW et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa); CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron D. SADOW (Ames, Iowa); Wenyu HUANG (Ames, Iowa); Frédéric A. PERRAS (Ames, Iowa); Marek PRUSKI (Ames, Iowa); Akalanka TENNAKOON (Ames, Iowa); Xun WU (Ames, Iowa); Anne M. LAPOINTE (Ithaca, New York) |
| ABSTRACT | Disclosed herein is a catalyst which comprises a silica core having an outer surface and a mesoporous silica shell having an outer surface and an inner surface with the inner surface being inside the outer surface of said mesoporous silica shell proximate to and surrounding the outer surface of said silica core. Wherein the outer surface of the mesoporous silica shell has openings leading to pores within the mesoporous silica shell which extend toward the outer surface of said silica core. The catalyst also includes catalytically active metal nanoparticles positioned within the pores proximate to said core, wherein the catalytic metal nanoparticles comprise about 0.0001 wt % to about 1.0 wt % of the catalyst. Also disclosed are methods of making the catalyst and using it to carry out a process for catalytically hydrogenolysizing a polyolefinic polymer. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/508055 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/08 (20130101) B01J 23/42 (20130101) Original (OR) Class B01J 35/40 (20240101) B01J 35/50 (20240101) B01J 35/647 (20240101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157353 | Bae et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chulsung Bae (Cohoes, New York); Eun Joo Park (Troy, New York); Sangtaik Noh (Troy, New York); Michael Pagels (Troy, New York) |
| ABSTRACT | The electrochemical energy conversion system of the present disclosure includes an anode, a cathode, and an ion exchange membrane including a polymer having an aromatic polymer chain and an alkylated substrate including an alkyl chain, and at least one ionic group. The alkylated substrate is bound to at least one aromatic group in the polymer chain via Friedel-Crafts alkylation of the at least one aromatic group. The alkylation reaction utilizes a haloalkylated tertiary alcohol or a haloalkylated alkene as a precursor. In the presence of an acid catalyst, a carbocation is generated in the precursor which reacts with the aromatic rings of the polymer chain. The at least one ionic group is then replaced with a desired cationic or anionic group using a substitution reaction. The membranes exhibit advantageous stability achieved through a simplified and scalable reaction scheme. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/381149 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 39/20 (20130101) B01J 41/14 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2287 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1032 (20130101) H01M 8/1072 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157598 | Holcomb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Grid Logic Incorporated (Lapeer, Michigan) |
| ASSIGNEE(S) | Grid Logic Incorporated (Lapeer, Michigan) |
| INVENTOR(S) | Matthew James Holcomb (Metamora, Michigan); Ira James Holcomb, Jr. (Oxford, Michigan) |
| ABSTRACT | Successive layers are printed, wherein each layer comprises at least a layer of the part and wherein the layer of the part is surrounded by a piece of a hot-isostatic press (HIP) can. The HIP can forms a sealed container with the part inside the HIP can is processed in a HIP. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495296 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Original (OR) Class B28B 11/04 (20130101) B28B 11/243 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 50/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157634 | Arriaga et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rodrigo Telles Arriaga (San Francisco, California); Caitlyn Christian Krikorian (Livermore, California); Elaine Lee (Moraga, California); Jennifer Lewis (Boston, Massachusetts) |
| ABSTRACT | A product includes a three-dimensional structure having a plurality of sequentially-formed layers comprised of liquid crystal elastomers. The liquid crystal elastomers in at least a predefined portion of a first of the layers are substantially aligned in a first orientation, and the liquid crystal elastomers in at least a predefined portion of a second of the layers are substantially aligned in a second orientation. In addition, each of the portions of the three-dimensional structure is characterized as exhibiting a shape change in response to a stimulus, where the shape change is reversible. |
| FILED | Monday, June 19, 2023 |
| APPL NO | 18/211514 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/188 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2021/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158235 | HU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianli HU (Morgantown, West Virginia); Sonit BALYAN (Morgantown, West Virginia); Changle JIANG (Morgantown, West Virginia) |
| ABSTRACT | In one aspect, the disclosure relates to compositions, processes, and devices for conversion of acetylene to hydrogen and carbon nanomaterials. In a further aspect, the disclosed methods comprise microwave irradiation of a feed stream comprising acetylene in the presence of a catalyst. Also disclosed are compositions produced by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/240325 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/26 (20130101) C01B 32/15 (20170801) Original (OR) Class C01B 2202/34 (20130101) C01B 2203/0277 (20130101) C01B 2203/1058 (20130101) C01B 2203/1082 (20130101) C01B 2203/1088 (20130101) C01B 2203/1235 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2002/88 (20130101) C01P 2004/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158324 | Huber et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | George Huber (Middleton, Wisconsin); Houqian Li (Middleton, Wisconsin); Jiayang Wu (Madison, Wisconsin); Clark Landis (Madison, Wisconsin) |
| ABSTRACT | A method to make primary alcohols, carboxylic acids, amines, and other value-added chemicals from plastic waste. The method includes the steps of pyrolyzing plastic waste to yield pyrolysis oil; hydroformylating the pyrolysis oil in the absence of any added co-reactants to yield a mixture comprising aldehydes; and hydrogenating, oxidizing, aminating, or aldolizing the mixture to yield a product comprising primary alcohols, carboxylic acids, amines, or larger (>C10) chemicals with carbonyl function groups. |
| FILED | Wednesday, June 14, 2023 |
| APPL NO | 18/334815 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/75 (20130101) B01J 23/464 (20130101) Acyclic or Carbocyclic Compounds C07C 27/08 (20130101) Original (OR) Class C07C 209/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158564 | Coates et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Wei You (Beijing, China PRC); Cheyenne Peltier (Ithaca, New York) |
| ABSTRACT | Hydrocarbonbackbone polymers with pendant quaternary ammonium groups and methods of making and using same. A polymer can be made by a ring-opening polymerization of quaternary ammonium bearing monomer(s), and, optionally, non-quaternary ammonium bearing monomer(s). A film including a polymer can be used as an anion exchange membrane in a device, such as, for example, a battery, a fuel cell, or the like. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/262677 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/05 (20170101) B01J 41/14 (20130101) B01J 47/12 (20130101) Heterocyclic Compounds C07D 295/037 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) Original (OR) Class C08G 2261/122 (20130101) C08G 2261/143 (20130101) C08G 2261/418 (20130101) C08G 2261/516 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/103 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158567 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene CHEN (Fort Collins, Colorado); Ethan QUINN (Fort Collins, Colorado); Zhen ZHANG (Fort Collins, Colorado) |
| ABSTRACT | Syndio-rich P3HB (sr-P3HB), readily synthesized from the eight-membered meso-dimethyl diolide, has a unique set of stereomicrostructures comprising enriched syndiotactic [rr] and no isotactic [mm] triads but abundant stereo-defects randomly distributed along the chain. This sr-P3HB material is characterized by high toughness (UT=96 MJ/m3), as a result of its high elongation at break (>400%) and tensile strength (34 MPa), crystallinity (Tm=114° C.), and optical clarity (due to its sub-micron spherulites), and good barrier properties, while it still biodegrades in freshwater and soil. On the other hand, iso-rich P3HB (ir-P3HB) can be synthesized from the eight-membered rac-dimethyl diolide. While sr-P3HB exhibits excellent adhesion strength toward a variety of substrates, both sr-P3HB and ir-P3HB can substantially toughen brittle stereoperfect biological or synthetic P3HB. Both sr-P3HB and ir-P3HB can also be obtained from the four-membered rac-beta-butyrolactone with appropriate catalysts. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/492554 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/06 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 67/04 (20130101) C08L 2205/025 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 167/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158601 | Hess et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. Hess (Louisville, Colorado); Ivan I. Smalyukh (Boulder, Colorado); Qingkun Liu (Boulder, Colorado); Joshua A. De La Cruz (Denver, Colorado); Blaise Fleury (Boulder, Colorado); Eldho Abraham (Boulder, Colorado); Vladyslav Cherpak (Westminster, Colorado); Bohdan Senyuk (Boulder, Colorado) |
| ABSTRACT | Disclosed are cellulose-based flexible gels containing cellulose nanorods, ribbons, fibers, and the like, and cellulose-enabled inorganic or polymeric composites, wherein the gels have tunable optical, heat transfer, and stiffness properties. The disclosed gels are in the form of hydrogels, organogels, liquid-crystal (LC) gels, and aerogels. Further disclosed are highly transparent and flexible cellulose nanofiber-polysiloxane composite aerogels featuring enhanced mechanical robustness, tunable optical anisotropy, and low thermal conductivity. Further disclosed are gels comprising cellulosic material derived from bacteria and processes for preparing bacterial cellulose gels and methods of use. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/530194 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 23/048 (20130101) B32B 2262/062 (20130101) B32B 2266/126 (20161101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/28 (20130101) Original (OR) Class C08J 9/0061 (20130101) C08J 2201/0504 (20130101) C08J 2201/0546 (20130101) C08J 2205/022 (20130101) C08J 2205/026 (20130101) C08J 2301/02 (20130101) C08J 2383/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158603 | DiPucchio et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca Claire DiPucchio (Wheat Ridge, Colorado); Katherine Rose Stevenson (Wheat Ridge, Colorado); Gregg Tyler Beckham (Golden, Colorado) |
| ABSTRACT | Methods, compositions of matter and processes for a base-mediated chemical deconstruction of varying amine-cured epoxy resins into constituent monomer alcohol products and amine materials are disclosed herein. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/383458 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 37/52 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/24 (20130101) Original (OR) Class C08J 2363/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158658 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinsong Huang (Chapel Hill, North Carolina); Shangshang Chen (Chapel Hill, North Carolina) |
| ABSTRACT | Described herein are oxidative-resistant ink solutions, comprising: a first composition of formula ABI3-yXy; one or more solvents; and a compound of Formula (II), or a salt thereof, wherein A, B, y, and X are described herein. Methods for preparing perovskite films using the oxidative-resistant ink solutions and the use of the films in solar cells and solar modules are additionally described. In certain embodiments, further described are methods of preparing perovskite films having reduced interfacial voids, comprising adding a compound of Formula (II), or a salt thereof, to the perovskite precursor solution used to prepare the film. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 18/270383 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/033 (20130101) C09D 11/037 (20130101) C09D 11/52 (20130101) Original (OR) Class Organic electric solid-state devices H10K 71/13 (20230201) H10K 85/50 (20230201) H10K 85/60 (20230201) H10K 85/655 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240158816 — METHODS AND COMPOSITIONS FOR THE PRODUCTION AND DEHYDRATION OF ISOPRENOL INTO ISOPRENE
| US 20240158816 | SUNDSTROM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric SUNDSTROM (San Mateo, California); Carolina ARAUJO BARCELOS (Emeryville, California); Taek Soon LEE (Berkeley, California) |
| ABSTRACT | The present invention provides for a method for producing isoprene and/or 1,4-dimethylcyclooctane (DMCO), the method comprising: (a) producing isoprenol (3-methyl-3-buten-1-ol) biologically; (b) recovering the isoprenol via gas stripping; (c) dehydrating the isoprenol into isoprene; and, (d) optionally converting the isoprene into DMCO. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/494656 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 1/24 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/04 (20130101) C10L 2200/043 (20130101) C10L 2200/0446 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/002 (20130101) Original (OR) Class C12P 5/007 (20130101) Enzymes C12Y 401/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158817 | Wahlen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley D. Wahlen (Rigby, Idaho); Asif Hasan Rony (Idaho Falls, Idaho); William A. Smith (Idaho Falls, Idaho); Lynn M. Wendt (Idaho Falls, Idaho) |
| ABSTRACT | Methods of separating plant matter are described herein. The methods may include contacting monocotyledonous plant matter with one or more enzymes or one or more organisms expressing one or more enzymes, where the monocotyledonous plant matter includes vascular bundles, pith, and rind. Following the enzymatic treatment, additional processing of the plant matter may be undertaken through mechanical means. The low-intensity mechanical processing may dislodge the pith, rind, and vascular bundles from one another while minimizing energy consumption and potential damage to the plant matter. Further processing may include sorting mechanisms such as mechanical screening or pneumatic air classification. The incorporation of enzymatic treatment prior to mechanical separation may enhance the efficiency and effectiveness of separating the rind, pith, and vascular bundles from one another compared to conventional mechanical separation methods. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511399 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) Original (OR) Class Enzymes C12Y 302/01015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158920 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Kuldeep Kumar (Pittsburgh, Pennsylvania); Rachel Dory Harris (Pittsburgh, Pennsylvania); Elizabeth Stephenie Brown-Tseng (Gibsonia, Pennsylvania); Kristi Maree Allen (Pittsburgh, Pennsylvania); Steven Edward Bowles (Pittsburgh, Pennsylvania); Silvia Bezer (Gibsonia, Pennsylvania); Steven Joseph Lemon (Lower Burrell, Pennsylvania); Mark William McMillen (Cabot, Pennsylvania) |
| ABSTRACT | Disclosed herein is a system for treating a magnesium or a magnesium alloy substrate comprising: a first pretreatment composition comprising a fluorometallic acid and free fluoride in an amount of 10 ppm to 500 ppm based on total weight of the first pretreatment composition and having a pH of 1.0 to 4.0; and a second pretreatment composition comprising a lanthanide series metal, the second pretreatment composition being substantially free of peroxide. Also disclosed are methods of treating a magnesium or magnesium alloy substrate. Treated magnesium and magnesium alloy substrates also are disclosed. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 18/551112 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) B33Y 80/00 (20141201) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 22/57 (20130101) Original (OR) Class Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 11/04 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 9/08 (20130101) C25D 11/00 (20130101) C25D 13/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158926 | Holewinski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Holewinski (Boulder, Colorado); Francisco Willian de Souza Lucas (Boulder, Colorado) |
| ABSTRACT | Disclosed herein are methods of electrochemical synthesis of hydroxyvaleric acid from levulinic acid. For example, disclosed herein are methods comprising electrochemical synthesis of hydroxyvaleric acid from levulinic acid, wherein the method is conducted in an electrochemical cell wherein a working electrode is in electrochemical contact with an aqueous electrolyte and levulinic acid, wherein the method comprises applying a potential to electrochemically reduce the levulinic acid to form hydroxyvaleric acid. Also disclosed herein are methods of synthesizing gamma-valerolactone from hydroxyvaleric acid, the method comprising acid-catalyzed esterification. Also disclosed herein are methods of use of the products produced by any of the methods herein. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501126 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/07 (20210101) Original (OR) Class C25B 3/25 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158935 | Akolkar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rohan Akolkar (Cleveland, Ohio); Benjamin P. Holcombe (Cleveland, Ohio); Nicholas Sinclair (Cleveland, Ohio); Ruwani Wasalathanthri (Cleveland, Ohio) |
| ABSTRACT | An anode for electrolytic chlorine evolution in a molten salt electrolyte includes a graphite substrate and a coating including a transition metal oxide disposed on at least a portion of the substrate. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363163 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/26 (20130101) C25B 9/09 (20210101) C25B 11/065 (20210101) C25B 11/077 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159211 | Pan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ocean Motion Technologies, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Boyang Pan (San Diego, California); Leverett Bezanson (Alpine, California); Paul Glick (Santa Cruz, California); Justin Walraven (San Diego, California); Mark Huang (Spring Valley, California); Nathaniel Bell (Tacoma, Washington); Alexander J. Orona (San Diego, California) |
| ABSTRACT | A wave energy capture system can include a plurality of arm assemblies. Each arm assembly includes a floatation device and an arm that is coupled to the floatation device and to a body via a pivot. The arm assemblies independently pivot around the pivots with respect to the body in response to movement of the floatation devices caused by waves in water. A mechanical energy capture system converts the independent pivoting of the plurality of arm assemblies around the pivots to electrical energy and provides the electrical energy to either an electronic device that is electrically coupled to the mechanical energy capture system to power the electronic device, or to a battery to recharge the battery. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468586 |
| CURRENT CPC | Machines or Engines for Liquids F03B 13/20 (20130101) Original (OR) Class Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2220/706 (20130101) F05B 2240/93 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159253 | Vacca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Vacca (West Lafayette, Indiana); Shaoyang Qu (West Lafayette, Indiana) |
| ABSTRACT | An electro-hydraulic actuator system includes a fixed-displacement hydraulic pump and a variable speed electric motor configured in combination to constitute an individual electro-hydraulic unit that is coupled to an actuator, and a bypass valve in parallel to the actuator. The system is configured to enable the actuator to be operated at actuation speeds that are higher than a maximum actuation capability of the pump at the maximum flow capability thereof, and at actuation speeds that are lower than a minimum actuation capability of the pump at the minimum flow capability thereof. The actuation velocity of the actuator may be controlled by controlling the speed of the electro-hydraulic unit and a size of an opening of the bypass valve. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545713 |
| CURRENT CPC | Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 11/024 (20130101) Original (OR) Class F15B 2211/615 (20130101) F15B 2211/3058 (20130101) F15B 2211/6651 (20130101) F15B 2211/6658 (20130101) F15B 2211/7053 (20130101) F15B 2211/20515 (20130101) F15B 2211/20538 (20130101) F15B 2211/20569 (20130101) F15B 2211/30525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159397 | Hong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seung-Hyuck Hong (Clifton Park, New York); Richard L. Hart (Broadalbin, New York); Honggang Wang (Clifton Park, New York); Anil Raj Duggal (Niskayuna, New York); Michael Anthony Benjamin (Cincinnati, Ohio) |
| ABSTRACT | A combustion section defines an axial direction, a radial direction, and a circumferential direction. The combustion section includes a casing that defines a diffusion chamber. A combustion liner is disposed within the diffusion chamber and defines a combustion chamber. The combustion liner is spaced apart from the casing such that a passageway is defined between the combustion liner and the casing. A fuel cell assembly is disposed in the passageway. The fuel cell assembly includes a fuel cell that extends between an inlet end and an outlet end. The inlet end receives a flow of air and fuel and the outlet end provides output products to the combustion chamber. The fuel cell extends at an angle between the inlet end and the outlet end relative to a radial projection line. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/984641 |
| CURRENT CPC | Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) Original (OR) Class F23R 3/28 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/2457 (20160201) H01M 8/04089 (20130101) H01M 2250/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159511 | Muir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Douglas Muir (Livermore, California); John E. Heebner (San Ramon, California); Daniel Ernest Mittelberger (Livermore, California) |
| ABSTRACT | Methods, systems and devices are described that enable measurement and characterization of complex laser pulses by relying on three interferograms that are measured simultaneously. The described three-phase spectral interferometry (3PSI) can meet the growing demand for optical recorders with long record and 1 ps or finer resolution. These techniques leverage various calibration and signal retrieval operations that allow improved system performance. An example method for determining characteristics of an input optical signal includes measuring the spectra associated with three interferograms produced at outputs of a three-by-three optical splitter, and determining an amplitude and a phase value of the input optical signal using those measurements and the results of a calibration procedure that characterizes point spread functions across multiple spectrometers and determines corrections factors for the spectrometers. |
| FILED | Thursday, November 30, 2023 |
| APPL NO | 18/525578 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02041 (20130101) Original (OR) Class Information Storage Based on Relative Movement Between Record Carrier and Transducer G11B 7/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159586 | SCHUCK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); Korea Research Institute of Chemical Technology (DaeJeon, South Korea); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | P. JAMES SCHUCK (New York, New York); CHANGHWAN LEE (New York, New York); EMMA XU (New York, New York); KAYUAN YAO (New York, New York); EMORY CHAN (Oakland, California); BRUCE COHEN (San Francisco, California); YUNG DOUG SUH (Seoul, South Korea); SANG HWAN NAM (Seoul, South Korea) |
| ABSTRACT | Exemplary nanoparticle and method for inducing photon avalanching using a nanoparticle can be provided. The nanoparticle can include, for example, at least 99% thulium doped nanocrystals of the nanoparticle. The nanoparticle can be composed of solely thulium. An atomic concentration of the thulium can be at least 8%. A near infrared excitation wavelength of the nanocrystals can be greater than about 1064 nm. The near infrared excitation wavelength can be between about 1400 nm to about 1490 nm. A passivated shell(s) can be included which can surround the nanocrystals. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/531271 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) Original (OR) Class G01J 2001/4466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159689 | Jones et al. |
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| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth M. C. Jones (Cedar Crest, New Mexico); Caroline Winters (Cedar Crest, New Mexico); Enrico C. Quintana (Albuquerque, New Mexico); Benjamin Roberts Halls (Albuquerque, New Mexico); Samuel Saiid Fayad (Urbana, Illinois); Dayna Glen Obenauf (Lancaster, California) |
| ABSTRACT | Digital image correlation is provided. The method comprises applying two or more unique X-ray attenuating patterns to a number of test samples and then applying physical deformation to the test samples. The test samples are irradiated concurrently with an X-ray source, and a path-integrated composite X-ray image is recorded that superimposes the unique X-ray attenuating patterns on each other. According to the path-integrated composite X-ray image, the method determines respective deformation of each of the unique X-ray attenuating patterns produced by the physical deformation of the test samples. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/229030 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/04 (20130101) Original (OR) Class G01N 23/083 (20130101) G01N 2223/401 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159918 | Porter et al. |
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| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Porter (Kansas City, Missouri); Amir Bahadori (Manhattan, Kansas); Walter McNeil (Manhattan, Kansas); Michael Pfeifer (Manhattan, Kansas); Nathanael Simerl (Manhattan, Kansas) |
| ABSTRACT | A dosimetry system for monitoring radiation exposure for a device under inspection comprises a support structure, a plurality of detectors, a signal processing unit, and a computing device. The support structure includes an upper surface on which the device under inspection is positioned. The detectors are positioned in proximity to the device under inspection. Each detector is configured to detect radiation and generate a radiation electronic signal whose level varies according to an amount of radiation to which the detector is exposed. The signal processing unit is configured to receive the radiation electronic signal from each detector and output data derived from the radiation electronic signals. The computing device is configured to receive the data from the signal processing unit and determine an accumulated radiation level for each detector. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508816 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/026 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159942 | Gopinath et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Juliet T. Gopinath (Boulder, Colorado); Samuel D. Gilinsky (Boulder, Colorado); Mo Zohrabi (Longmont, Colorado); Victor M. Bright (Boulder, Colorado); Omkar D. Supekar (Painted Post, New York); Wei Yang Lim (Eden Prairie, Minnesota) |
| ABSTRACT | A microlens array includes a bottom electrode chip, a sidewall electrode chip, and a top glass chip configured to cooperate to define an array of cavities, each one of the array of cavities containing a fluid. The fluid is a mixture of a polar liquid and a non-polar liquid, in contact with one of the array of sidewalls at a contact angle. The bottom electrode chip includes a plurality of electrical contacts. The sidewall electrode chip includes an array of sidewalls, each including an electrode layer and an insulator layer. When a voltage is applied across the fluid contained a cavity via electrical contacts and the electrode layer of the cavity, the contact angle of the fluid with the sidewall is modified, in embodiments without affecting the contact angle of fluid contained in other ones of the plurality of array of cavities. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/508114 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/14 (20130101) G02B 3/0056 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/294 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159959 | Chorpening et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin T. Chorpening (Pittsburgh, Pennsylvania); Michael P. Buric (Pittsburgh, Pennsylvania); Juddha Thapa (Pittsburgh, Pennsylvania) |
| ABSTRACT | One or more embodiments relates to a system for producing a waveguide, a method of making a waveguide and a waveguide having low surface roughness, adapted to minimize loss and noise while producing a circular beam that can be used in the visible or short-wave spectral regime. The waveguide includes a glass capillary tube having an outer surface and an inner surface defining a hollow core; a metal layer deposited on at least the inner surface; and a polymer layer overcoat deposited on at least the metal layer and in fluid communication with the hollow core. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/510819 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/1063 (20180101) C03C 2217/256 (20130101) C03C 2218/11 (20130101) Optical Elements, Systems, or Apparatus G02B 6/032 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160003 | Ravizza et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank Ravizza (Livermore, California); Brian J. Bauman (Livermore, California); Tiffany Yslas (San Lorenzo, California); Lisle B. Hagler (Livermore, California); Amy Wat (Oakland, California); Jonathan Michael Gordon (Elk Grove, California); Michael Yiu-Ming Wong (Livermore, California); Alexander J. Pertica (Livermore, California); Hilary Johnson (Livermore, California); Jordan Smilo (Livermore, California) |
| ABSTRACT | Disclosed are methods and devices related to a radial mounting interface holding a compact monolithic telescope, or generally an optical component, with robust optical alignment. An example optical mounting apparatus includes a mounting structure including a plurality of segments that are configured to surround a circumferential area of a monolithic optical device and to hold the monolithic optical device in place, wherein each of the plurality of segments includes a ridged or a grooved interface surface to couple the mounting structure to corresponding grooves or ridges in a surface of the monolithic optical device. The apparatus further includes an elastomeric material confined between the ridged or grooved interface surface of the mounting structure and the one or more corresponding grooves or ridges in the surface of the monolithic optical device. Also disclosed are thermal management features that passively enable diffraction-limited performance of large aperture monolithic optics. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506920 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 23/02 (20130101) G02B 23/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160084 | Muir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| INVENTOR(S) | Ryan D. Muir (Livermore, California); Vincent J. Hernandez (Brisbane, California); Brandon W. Buckley (Walnut Creek, California); Daniel E. Mittelberger (Livermore, California); John E. Heebner (San Ramon, California) |
| ABSTRACT | The nonlinearities of cascaded and series configurations of Mach-Zehnder electrooptic modulators are utilized to increase signal bandwidth and boost signal fidelity in electronic digital to analog converters. |
| FILED | Tuesday, November 28, 2023 |
| APPL NO | 18/521839 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/212 (20210101) G02F 1/2255 (20130101) G02F 1/2257 (20130101) G02F 7/00 (20130101) Original (OR) Class Transmission H04B 10/556 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160971 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IonQ, Inc. (College Park, Maryland); University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingfeng WANG (College Park, Maryland); Ming LI (College Park, Maryland); Yunseong NAM (College Park, Maryland) |
| ABSTRACT | Aspects of the present disclosure describe a method including predicting a first set of ansatz terms and a first plurality of amplitudes associated with the first set of ansatz terms; minimizing energy of the system based on the first set of ansatz terms and the first plurality of amplitudes; computing perturbative corrections using one or more ansatz wavefunctions; determining whether energy of the system converges; and predicting, in response to determining that the energy of the system does not converge, a second set of ansatz terms and a second plurality of amplitudes associated with the second set of ansatz terms. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/411709 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5094 (20130101) G06F 30/20 (20200101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161307 | Dao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NANYANG TECHNOLOGICAL UNIVERSITY (Singapore, Singapore); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (cAMBRIDGE, Massachusetts); BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ming Dao (Cambridge, Massachusetts); Subra Suresh (Singapore, Singapore); George Karniadakis (Providence,, Rhode Island); Shengze Cai (Providence, Rhode Island); He Li (Providence, Rhode Island) |
| ABSTRACT | Methods and systems for estimating fluid flow characteristics are provided. In one embodiment, a method is provided that includes receiving a plurality of images of fluid flow at a plurality of times. The images may be analyzed with a machine learning model to predict one or more physical characteristics of the fluid flow, such as a velocity field, a pressure field, and/or a stress field. A loss measure may be calculated for the physical characteristics based on physical fluid flow constraints, boundary condition constraints, and/or data mismatch constraints. The machine learning model may be updated based on the loss value. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 18/282679 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/20 (20130101) Original (OR) Class G06T 2207/10016 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161938 | SHUMLAK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uri SHUMLAK (Seattle, Washington); Brian A. NELSON (Seattle, Washington); Raymond GOLINGO (Seattle, Washington) |
| ABSTRACT | An example method includes directing gas, via one or more first valves, from within an inner electrode to an acceleration region between the inner electrode and an outer electrode that substantially surrounds the inner electrode, directing gas, via two or more second valves, from outside the outer electrode to the acceleration region, and applying, via a power supply, a voltage between the inner electrode and the outer electrode, thereby converting at least a portion of the directed gas into a plasma having a substantially annular cross section, the plasma flowing axially within the acceleration region toward a first end of the inner electrode and a first end of the outer electrode and, thereafter, establishing a Z-pinch plasma that flows between the first end of the outer electrode and the first end of the inner electrode. Related plasma confinement systems and methods are also disclosed herein. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/391847 |
| CURRENT CPC | Fusion Reactors G21B 1/05 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/04 (20130101) H05H 1/06 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161963 | Campbell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Helion Energy, Inc. (Everett, Washington) |
| ASSIGNEE(S) | Helion Energy, Inc. (Everett, Washington) |
| INVENTOR(S) | Brian Campbell (Shoreline, Washington); David Kirtley (Seattle, Washington); Christopher James Pihl (Woodinville, Washington); Akihisa Shimazu (Seattle, Washington) |
| ABSTRACT | A single-turn coil and supporting structure for producing intense magnetic fields are described. Magnetic field and mechanical stress analyses aid in designing a magnetic coil assembly that can produce peak magnetic fields in excess of 10 Tesla in large cavities for more than 1,000 pulses. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/526574 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 5/04 (20130101) H01F 5/06 (20130101) H01F 27/263 (20130101) H01F 27/266 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162441 | JONSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert JONSON (Berkeley, California); Michael TUCKER (Piedmont, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to batteries with an organic cathode and a solid electrolyte. In one aspect, a device includes an anode, a cathode, and a separator disposed between the anode and the cathode. The anode comprises lithium. The cathode comprises a catholyte and an organic active material disposed therein. The separator comprises a solid-state electrolyte. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504478 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/60 (20130101) Original (OR) Class H01M 4/382 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) H01M 12/02 (20130101) H01M 2004/027 (20130101) H01M 2004/028 (20130101) H01M 2300/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162674 | DANTUS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Marcos DANTUS (Okemos, Michigan); Jacob Anthony STAMM (Howell, Michigan); Jorge Guillermo BENEL MOGROVEJO (Lima, Peru) |
| ABSTRACT | A laser system employs a laser, a pulse shaper, and a controller configured to measure phase variations on pre-compressed laser pulses. In another aspect, a laser apparatus and method include programmed software instructions which measure phase variations of ultrafast laser pulses. A further aspect of the present system and method includes a laser, an active pulse shaper, and a controller which measure and/or correct distortions of laser pulses with π/2 scanning. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/278910 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0014 (20130101) H01S 3/0057 (20130101) Original (OR) Class H01S 3/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162859 | TABRIZIAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (ALBUQUERQUE, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roozbeh TABRIZIAN (Gainesville, Florida); Kevin S. JONES (Gainesville, Florida); George T. WANG (Albuquerque, New Mexico) |
| ABSTRACT | In one aspect, the disclosure relates to a super high frequency (SHF) or extremely high frequency (EHF) bulk acoustic resonator that includes a nanostructure, wherein the nanostructure includes a substrate, a three-dimensional structure disposed on the substrate, wherein the three-dimensional structure includes a planar structure including at least one nanocomponent and a matrix material contacting the nanocomponent on at least one side, the matrix material including an SiGe alloy or Ge. The disclosed bulk acoustic resonator operates at frequencies of from about 100 MHz to about 100 GHz, is capable of self-amplification upon application of direct current or voltage, and has a Q factor amplification exceeding 1. Also disclosed are methods for amplification of mechanical resonance in the disclosed bulk acoustic resonators and devices incorporating the bulk acoustic resonators. |
| FILED | Monday, November 27, 2023 |
| APPL NO | 18/519503 |
| CURRENT CPC | Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 5/326 (20130101) Original (OR) Class Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/173 (20130101) H03H 9/703 (20130101) H03H 9/02015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240156370 | Vipperman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | Jeffrey Vipperman (Pittsburgh, Pennsylvania); Catherine Palmer (Pittsburgh, Pennsylvania); Erik Rauterkus (Pittsburgh, Pennsylvania); Jacalynn Ona Sharp (Silver Spring, Maryland); Christopher Dumm (Verona, Pennsylvania); Joseph Lyle Koch (Ventura, California) |
| ABSTRACT | A portable hearing screening and amplification device structured to be coupled to a headset includes: a housing, a plurality of buttons, a plurality of indicators, a microphone circuit, an output circuit, a power source, and a controller. Upon passing a background noise test, the portable hearing screening and amplification device is structured to transmit a plurality of hearing screening tones to the headset for a user for testing of the plurality of hearing screening tones and complete the hearing screening based on responses of the user related to the plurality of hearing screening tones, the responses including a number of hearing screening tones that the user has perceived during the hearing screening. Based on a determination that the number of hearing screening tones perceived is less than a prerequisite number, the portable hearing screening and amplification device is further structured to switch to amplification mode and provide amplification. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 18/550154 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/123 (20130101) Original (OR) Class A61B 5/742 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156963 | Thomson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Thomson (Madison, Wisconsin); Jue Zhang (Madison, Wisconsin); Igor Slukvin (Verona, Wisconsin); Aditi Majumder (Madison, Wisconsin); Ho Sun Jung (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides genetically engineered immune cells that express an anti-GD2 chimeric antigen receptor, methods of generating these cells, and methods of treating tumors using the genetically engineered cells. |
| FILED | Tuesday, April 18, 2023 |
| APPL NO | 18/302636 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/461 (20230501) A61K 39/4613 (20230501) A61K 39/4614 (20230501) A61K 39/4631 (20230501) A61K 39/464471 (20230501) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/3084 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0642 (20130101) C12N 5/0645 (20130101) C12N 5/0646 (20130101) C12N 2506/45 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156989 | Pyle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | April D. Pyle (Los Angeles, California); Courtney S. Young (Los Angeles, California); Melissa J. Spencer (Los Angeles, California) |
| ABSTRACT | The present disclosure provides a method of modifying a mutant dystrophin gene in the genome of a cell. The present disclosure further provides compositions and kits for modifying a mutant dystrophin gene in the genome of a cell. |
| FILED | Monday, April 24, 2023 |
| APPL NO | 18/305863 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2217/075 (20130101) A01K 2227/105 (20130101) A01K 2267/0306 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Original (OR) Class A61K 48/0091 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Peptides C07K 14/4708 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) C12N 15/113 (20130101) C12N 15/861 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157288 | PAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Bin PAN (Los Angeles, California); Noah MALMSTADT (Altadena, California) |
| ABSTRACT | A purification system for ionic liquid solvents includes an ionic liquid source that includes a first flow controller configured to provide a first flow stream at a first flow rate where the first flow stream including an ionic liquid requiring purification. An extraction liquid source provides a second flow stream including an extraction liquid that is immiscible with the ionic liquid. A mixing component is configured to mix the first flow stream and the second flow stream and output a mixed flow stream that includes a retentate phase and a permeate phase. A separator assembly includes a separation membrane interposed between a first flow channel assembly and a second channel assembly. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/389017 |
| CURRENT CPC | Separation B01D 53/228 (20130101) Original (OR) Class B01D 71/022 (20130101) B01D 2256/16 (20130101) B01D 2313/06 (20130101) B01D 2313/10 (20130101) B01D 2313/12 (20130101) B01D 2313/13 (20130101) B01D 2319/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157295 | Fan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Wyoming (Laramie, Wyoming) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming); Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Maohong Fan (Ames, Iowa); Xiaowen Zhang (Laramie, Wyoming); Yangyan Gao (Laramie, Wyoming); Armistead G. Russell (Atlanta, Georgia); Xin He (Laramie, Wyoming) |
| ABSTRACT | A transformational energy efficient technology using ionic liquid (IL) to couple with monoethanolamine (MEA) for catalytic CO2 capture is disclosed. [EMmim+][NTF2−] based catalysts are rationally synthesized and used for CO2 capture with MEA. A catalytic CO2 capture mechanism is disclosed according to experimental and computational studies on the [EMmim+][NTF2−] for the reversible CO2 sorption and desorption. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/049226 |
| CURRENT CPC | Separation B01D 53/8671 (20130101) Original (OR) Class B01D 53/8693 (20130101) B01D 2257/504 (20130101) B01D 2259/816 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0278 (20130101) B01J 37/343 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157346 | MIRKIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. MIRKIN (Wilmette, Illinois); Yijin KANG (Naperville, Illinois); Liliang HUANG (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are trimetallic PtAu-based nanocatalysts for electrochemical hydrogen production and screening methods thereof. Nanocatalysts are produced through a polymer pen lithography (PPL) technique, which enables large-scale fabrication of nanoparticle arrays with programmable specifications such as size, shape, and composition, providing a route to the high-throughput screening and discovery of new catalysts. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/217127 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) B01J 23/8933 (20130101) Original (OR) Class B01J 35/393 (20240101) B01J 37/08 (20130101) B01J 37/0221 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) C25B 15/02 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157353 | Bae et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chulsung Bae (Cohoes, New York); Eun Joo Park (Troy, New York); Sangtaik Noh (Troy, New York); Michael Pagels (Troy, New York) |
| ABSTRACT | The electrochemical energy conversion system of the present disclosure includes an anode, a cathode, and an ion exchange membrane including a polymer having an aromatic polymer chain and an alkylated substrate including an alkyl chain, and at least one ionic group. The alkylated substrate is bound to at least one aromatic group in the polymer chain via Friedel-Crafts alkylation of the at least one aromatic group. The alkylation reaction utilizes a haloalkylated tertiary alcohol or a haloalkylated alkene as a precursor. In the presence of an acid catalyst, a carbocation is generated in the precursor which reacts with the aromatic rings of the polymer chain. The at least one ionic group is then replaced with a desired cationic or anionic group using a substitution reaction. The membranes exhibit advantageous stability achieved through a simplified and scalable reaction scheme. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/381149 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 39/20 (20130101) B01J 41/14 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2287 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1032 (20130101) H01M 8/1072 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240157634 | Arriaga et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rodrigo Telles Arriaga (San Francisco, California); Caitlyn Christian Krikorian (Livermore, California); Elaine Lee (Moraga, California); Jennifer Lewis (Boston, Massachusetts) |
| ABSTRACT | A product includes a three-dimensional structure having a plurality of sequentially-formed layers comprised of liquid crystal elastomers. The liquid crystal elastomers in at least a predefined portion of a first of the layers are substantially aligned in a first orientation, and the liquid crystal elastomers in at least a predefined portion of a second of the layers are substantially aligned in a second orientation. In addition, each of the portions of the three-dimensional structure is characterized as exhibiting a shape change in response to a stimulus, where the shape change is reversible. |
| FILED | Monday, June 19, 2023 |
| APPL NO | 18/211514 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/188 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2021/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158441 | HE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRANDEIS UNIVERSITY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongjian HE (Waltham, Massachusetts); Bing XU (Newton, Massachusetts) |
| ABSTRACT | The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/498452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 35/00 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) C07K 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158448 | Discher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis Discher (Philadelphia, Pennsylvania); Abdelaziz Jalil (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure includes methods and compositions that can efficiently enhance macrophage-mediated phagocytosis of target cells by inhibiting the SIRPα/CD47 interaction in a way that minimizes off-target toxicity. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/546695 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 14/001 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158601 | Hess et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. Hess (Louisville, Colorado); Ivan I. Smalyukh (Boulder, Colorado); Qingkun Liu (Boulder, Colorado); Joshua A. De La Cruz (Denver, Colorado); Blaise Fleury (Boulder, Colorado); Eldho Abraham (Boulder, Colorado); Vladyslav Cherpak (Westminster, Colorado); Bohdan Senyuk (Boulder, Colorado) |
| ABSTRACT | Disclosed are cellulose-based flexible gels containing cellulose nanorods, ribbons, fibers, and the like, and cellulose-enabled inorganic or polymeric composites, wherein the gels have tunable optical, heat transfer, and stiffness properties. The disclosed gels are in the form of hydrogels, organogels, liquid-crystal (LC) gels, and aerogels. Further disclosed are highly transparent and flexible cellulose nanofiber-polysiloxane composite aerogels featuring enhanced mechanical robustness, tunable optical anisotropy, and low thermal conductivity. Further disclosed are gels comprising cellulosic material derived from bacteria and processes for preparing bacterial cellulose gels and methods of use. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/530194 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 23/048 (20130101) B32B 2262/062 (20130101) B32B 2266/126 (20161101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/28 (20130101) Original (OR) Class C08J 9/0061 (20130101) C08J 2201/0504 (20130101) C08J 2201/0546 (20130101) C08J 2205/022 (20130101) C08J 2205/026 (20130101) C08J 2301/02 (20130101) C08J 2383/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158733 | Kotecha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | O2M Technologies, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mrignayani Kotecha (Chicago, Illinois); Boris Meerovich Epel (Chicago, Illinois); Eliyas Siddiqui (Chicago, Illinois); Safa Hameed (Chicago, Illinois) |
| ABSTRACT | A method includes placing a sample of cells, tissue, or an organ into an oxygen imaging system, circulating a humidified gas mixture around the tissue or organ, circulating conditioned air through the oxygen imaging system to maintain a temperature around the sample, and acquiring a three-dimensional oxygen map of the sample. The oxygen map provides a quantitative measure of cell viability and functionality. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506801 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 29/24 (20130101) C12M 41/12 (20130101) C12M 41/46 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158814 | Scott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan Alexander Scott (Evanston, Illinois); Sijia Yi (Evanston, Illinois) |
| ABSTRACT | The present invention provides nanocarriers for delivering polynucleotide sequences to cells, specifically immune cells, including dendritic cells and methods of use. The methods provide improved delivery and reduced toxicity over prior methods. The method of the present disclosure provide a system for delivering nucleic acids to a cell, consisting of a synthetic PEG-b-PPS-linker-DP polymer for producing nanostructures comprising a poly(ethylene glycol)-blockpoly (propylene sulfide) copolymer (PEG-b-PPS) conjugated with a dendritic-specific branched cationic peptide (DP). The system provides a non-toxic in-vitro method of delivering a polynucleotide to immune cells, including dendritic cells, comprising of contacting the cell in cell culture medium with a nanocarrier wherein the method is non-toxic to the cells. The methods described in the invention can be used for treating a subject in need of gene therapy, comprising administering to the subject an effective amount of the system comprising of a polynucleotide, wherein the polynucleotide contains a gen of interest for gene therapy. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 18/551095 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6455 (20170801) A61K 47/6935 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0639 (20130101) C12N 15/88 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158925 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenzhen LI (Ames, Iowa); Yifu CHEN (Ames, Iowa); Hengzhou LIU (Ames, Iowa) |
| ABSTRACT | The present disclosure relates to a membrane-free alkaline electrolyzer (MFAEL) system for converting nitrogen (N)-containing waste into ammonia (NH3). The system includes a reaction medium comprising H2O—NaOH—KOH; a pair of electrodes, wherein the electrodes are in contact with the reaction medium; and a power supply operably connected to the electrodes. Also disclosed is a method for converting nitrogen (N)-containing waste into ammonia (NH3). This method involves introducing nitrogen (N)-containing waste into a membrane-free alkaline electrolyzer (MFAEL) system and applying current between the electrodes to perform oxidative and reductive transformation of the nitrogen (N)-containing waste into ammonia (NH3). |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/485096 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/27 (20210101) Original (OR) Class C25B 9/17 (20210101) C25B 9/60 (20210101) C25B 11/046 (20210101) C25B 15/08 (20130101) C25B 15/021 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158926 | Holewinski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Holewinski (Boulder, Colorado); Francisco Willian de Souza Lucas (Boulder, Colorado) |
| ABSTRACT | Disclosed herein are methods of electrochemical synthesis of hydroxyvaleric acid from levulinic acid. For example, disclosed herein are methods comprising electrochemical synthesis of hydroxyvaleric acid from levulinic acid, wherein the method is conducted in an electrochemical cell wherein a working electrode is in electrochemical contact with an aqueous electrolyte and levulinic acid, wherein the method comprises applying a potential to electrochemically reduce the levulinic acid to form hydroxyvaleric acid. Also disclosed herein are methods of synthesizing gamma-valerolactone from hydroxyvaleric acid, the method comprising acid-catalyzed esterification. Also disclosed herein are methods of use of the products produced by any of the methods herein. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501126 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/07 (20210101) Original (OR) Class C25B 3/25 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158939 | PHAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELECTRASTEEL, INC. (Boulder, Colorado) |
| ASSIGNEE(S) | ELECTRASTEEL, INC. (Boulder, Colorado) |
| INVENTOR(S) | Ai Quoc PHAM (Boulder, Colorado); Sandeep NIJHAWAN (Boulder, Colorado); Adolfredo ALVAREZ (Boulder, Colorado); Steven FATUR (Boulder, Colorado) |
| ABSTRACT | Methods and systems for producing iron from an iron-containing ore and removing impurities found in the iron-containing ore are disclosed. For example, a method for producing iron comprises providing a feedstock having an iron-containing ore and one or more impurities to a dissolution subsystem comprising a first electrochemical cell; producing an iron-rich solution, in the dissolution subsystem; treating the iron-rich solution to remove at least a portion of one or more impurities by raising a pH of the iron-rich solution from an initial pH to an adjusted pH thereby precipitating at least a portion of the one or more impurities in the treated iron-rich solution; delivering the treated iron-rich solution to an iron-plating subsystem having a second electrochemical cell; second electrochemically reducing at least a first portion of the transferred formed Fe2+ ions to Fe metal; and removing the Fe metal from the second electrochemical cell thereby producing iron. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/550189 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/06 (20130101) Original (OR) Class C25C 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159211 | Pan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ocean Motion Technologies, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Boyang Pan (San Diego, California); Leverett Bezanson (Alpine, California); Paul Glick (Santa Cruz, California); Justin Walraven (San Diego, California); Mark Huang (Spring Valley, California); Nathaniel Bell (Tacoma, Washington); Alexander J. Orona (San Diego, California) |
| ABSTRACT | A wave energy capture system can include a plurality of arm assemblies. Each arm assembly includes a floatation device and an arm that is coupled to the floatation device and to a body via a pivot. The arm assemblies independently pivot around the pivots with respect to the body in response to movement of the floatation devices caused by waves in water. A mechanical energy capture system converts the independent pivoting of the plurality of arm assemblies around the pivots to electrical energy and provides the electrical energy to either an electronic device that is electrically coupled to the mechanical energy capture system to power the electronic device, or to a battery to recharge the battery. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468586 |
| CURRENT CPC | Machines or Engines for Liquids F03B 13/20 (20130101) Original (OR) Class Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2220/706 (20130101) F05B 2240/93 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159669 | BRUECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven R.J. BRUECK (Albuquerque, New Mexico); Alexander NEUMANN (Albuquerque, New Mexico); Juan Jose FARIA BRICENO (Albuquerque, New Mexico) |
| ABSTRACT | A method and system for high-speed 2Θ multi-point scatterometry is disclosed. The method includes directing a laser beam from a laser light source to a collimation optical system that collimates the laser beam to a collimated laser beam; adjusting a polarization of the collimated laser beam using a polarization control optics; directing the collimated laser beam that is polarized by a first optical system to illuminate a focal area on a sample surface; receiving reflected light from the focus of the laser light source at the sample surface by a second optical system; detecting the reflected light by a detector system to produce detection signals; and processing the detection signals to measure parameters of the sample surface. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/773115 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/47 (20130101) Original (OR) Class G01N 2021/4735 (20130101) G01N 2021/4792 (20130101) G01N 2201/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159676 | JACOB et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zubin JACOB (West Lafayette, Indiana); Hyunsoo CHOI (West Lafayette, Indiana); Fanglin BAO (West Lafayette, Indiana); Adrian Ezequiel RUBIO LOPEZ (Santiago, Chile) |
| ABSTRACT | Imaging systems and methods are disclosed for detecting objects in low photon environments. Embodiments modulate separate groups of photons from the same source, modulate the wavefronts of the separate groups of photons, recombine the modulated photons, utilize information of the recombined photons (such as by utilizing pre-trained reinforcement learning networks and/or by using the Fisher information), and iteratively adjust the manner in which the wavefronts are modulated to detect objects in the sub-Rayleigh region, and in dim regions with a small number of photons, for example, on the order of 10,000 per second or less. Further embodiments determine the iterative modulation patterns utilizing pre-trained reinforcement learning networks. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508835 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159942 | Gopinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Juliet T. Gopinath (Boulder, Colorado); Samuel D. Gilinsky (Boulder, Colorado); Mo Zohrabi (Longmont, Colorado); Victor M. Bright (Boulder, Colorado); Omkar D. Supekar (Painted Post, New York); Wei Yang Lim (Eden Prairie, Minnesota) |
| ABSTRACT | A microlens array includes a bottom electrode chip, a sidewall electrode chip, and a top glass chip configured to cooperate to define an array of cavities, each one of the array of cavities containing a fluid. The fluid is a mixture of a polar liquid and a non-polar liquid, in contact with one of the array of sidewalls at a contact angle. The bottom electrode chip includes a plurality of electrical contacts. The sidewall electrode chip includes an array of sidewalls, each including an electrode layer and an insulator layer. When a voltage is applied across the fluid contained a cavity via electrical contacts and the electrode layer of the cavity, the contact angle of the fluid with the sidewall is modified, in embodiments without affecting the contact angle of fluid contained in other ones of the plurality of array of cavities. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/508114 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/14 (20130101) G02B 3/0056 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/294 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240160231 | Ismagilov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. Ismagilov (Chicago, Illinois); Bo Zheng (Chicago, Illinois); Cory John Gerdts (Chicago, Illinois) |
| ABSTRACT | The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/395300 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 25/314 (20220101) B01F 33/3021 (20220101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/0059 (20130101) B01J 2219/00522 (20130101) B01J 2219/00585 (20130101) B01J 2219/00599 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/0293 (20130101) B01L 3/502746 (20130101) B01L 3/502784 (20130101) B01L 2200/0673 (20130101) B01L 2300/0816 (20130101) B01L 2300/0838 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/38 (20130101) G01N 35/08 (20130101) G01N 2035/1034 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 7/0694 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161014 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongfei Zhang (Vestal, New York); Shuangfei Zhai (Binghamton, New York) |
| ABSTRACT | A method of modelling data, comprising training an objective function of a linear classifier, based on a set of labeled data, to derive a set of classifier weights; defining a posterior probability distribution on the set of classifier weights of the linear classifier; approximating a marginalized loss function for an autoencoder as a Bregman divergence, based on the posterior probability distribution on the set of classifier weights learned from the linear classifier; and classifying unlabeled data using the autoencoder according to the marginalized loss function. |
| FILED | Sunday, January 07, 2024 |
| APPL NO | 18/406198 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/214 (20230101) G06F 18/2411 (20230101) Computer Systems Based on Specific Computational Models G06N 3/045 (20230101) G06N 3/047 (20230101) G06N 3/084 (20130101) G06N 7/01 (20230101) G06N 20/10 (20190101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 10/774 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161291 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of The Stevens Institute of Technology (Hoboken, New Jersey); The Trustees of the Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinho Kim (Jersey City, New Jersey); Seyed Mohammad Mir (Hoboken, New Jersey); Jiawen Chen (Hoboken, New Jersey); Gordana Vunjak-Novakovi (New York, New York); Meghan Pinezich (New York, New York); Maria Hudock (New York, New York) |
| ABSTRACT | A bioreactor is disclosed that can be used to study living tissues (e.g., lung tissues) in an environment that mimics the natural environment. Pressure, flow and force modules enable imitation of in vivo conditions. An integrated imaging module allows for the airway tissues and cells of interest to be visualized and monitored continuously and non-destructively at the single-cell level. A method of use of the created systems can be utilized to quantify mucociliary fluid movements across the luminal surface of in vitro-cultured human airway tissue via in situ particle tracking and analysis is also disclosed. Another method of use of systems created in accordance with an embodiment of the present invention is to generate in vitro-cultured human airway tissue with severely impaired mucociliary flow by depositing thick viscous mucus-mimetic fluid on to the airway lumen. Methods of de-epithelialization and replacement of living cells are also disclosed. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505986 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/30004 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161319 | Ingle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Atul Ingle (Madison, Wisconsin); Sacha Jungerman (Madison, Wisconsin); Yin Li (Madison, Wisconsin); Mohit Gupta (Madison, Wisconsin) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for estimating a depth and orientation of a portion of a scene using a single-photon detector and diffuse light source are provided. In some embodiments, a system comprises: a light source; an image sensor comprising a pixel having a field of view of at least one degree; a hardware processor programmed to: cause the light source to emit a sequence of n defocused pulses toward the scene; receive, from the pixel, information indicative of arrival times of light from the scene; generate a transient histogram using the information indicative of arrival times of light from the scene; and estimate one or more properties of a portion of the scene within the field of view of the pixel based on the transient histogram, wherein the one or more properties of the portion of the scene includes at least a depth. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/983925 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4865 (20130101) G01S 17/10 (20130101) Image Data Processing or Generation, in General G06T 7/13 (20170101) G06T 7/521 (20170101) Original (OR) Class G06T 2207/10028 (20130101) Pictorial Communication, e.g Television H04N 5/2256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161926 | Krebs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); Wisconsin Alumni Research Foundation (Madison, Wisconsin); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Olivia Krebs (Cleveland Heights, Ohio); Pallavi Tiwari (Waunakee, Wisconsin); Germán Corredor (Beachwood, Ohio) |
| ABSTRACT | The present disclosure relates to a method. The method includes accessing a segmented digitized pathology image corresponding to a high grade glioma (HGG) patient having a first biological sex. The segmented digitized pathology image identifies nuclei. The nuclei are classified as tumor infiltrating lymphocytes (TILs) or non-TILs. Sex specific features related to the nuclei identified as the TILs and the non-TILs are extracted. The sex specific features characterize a spatial organization of the TILs and the non-TILs. The sex specific features are operated on with a sex specific machine learning model corresponding to the first biological sex to generate a sex specific patient risk score. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/493862 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/00 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162342 | Dhingra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NUTech Ventures, Inc. (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Archit Dhingra (Lincoln, Nebraska); Peter A. Dowben (Lincoln, Nebraska); Alexey Lipatov (Lincoln, Nebraska); Alexander Sinitskii (Lincoln, Nebraska) |
| ABSTRACT | HfS3-based semiconductor devices that include a substrate layer, a substrate dielectric layer formed on the substrate layer, a bulk layer formed on the substrate dielectric layer, the bulk layer comprising as-synthesized n-type HfS3, and a p-type HfS3 layer formed on the bulk layer, wherein the p-type HfS3 comprises the two-dimensional hole gas (2DHG) layer. FET devices further include first and second electrodes located on the substrate dielectric layer and forming a semiconductor channel between the first and second electrodes. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/490151 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 29/7787 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162674 | DANTUS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Marcos DANTUS (Okemos, Michigan); Jacob Anthony STAMM (Howell, Michigan); Jorge Guillermo BENEL MOGROVEJO (Lima, Peru) |
| ABSTRACT | A laser system employs a laser, a pulse shaper, and a controller configured to measure phase variations on pre-compressed laser pulses. In another aspect, a laser apparatus and method include programmed software instructions which measure phase variations of ultrafast laser pulses. A further aspect of the present system and method includes a laser, an active pulse shaper, and a controller which measure and/or correct distortions of laser pulses with π/2 scanning. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/278910 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0014 (20130101) H01S 3/0057 (20130101) Original (OR) Class H01S 3/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240162942 | Zheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lehigh University (Bethlehem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yahong Rosa Zheng (Bethlehem, Pennsylvania); Xiyuan Zhu (Bethlehem, Pennsylvania) |
| ABSTRACT | An acoustic transmission device may communicate sensing data via one or more multiple-input multiple-output (MIMO) transmissions. The device may comprise a serial peripheral interface (SPI) and/or a phase shifting key (PSK) modulator. The device may be configured to provide a first SPI signal, perhaps including one or more coded information bits, to the PSK modulator. The device may provide a second SPI signal, perhaps including a synchronous clock signal, to the PSK modulator. The device may generate of one or more symbols on N transmit branches based on the first SPI signal. The device may generate of at least one carrier frequency with one or more phases to form one or more phased carriers based on the second SPI signal. The device may control a transmission of the sensing data (e.g., video) via the one or more symbols on the N transmit branches on the one or more phased carriers. |
| FILED | Friday, May 05, 2023 |
| APPL NO | 18/143839 |
| CURRENT CPC | Transmission H04B 7/0413 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 27/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240163155 | Abdellatif et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hussam Abdellatif (Boston, Massachusetts); Paboda Viduneth Ariyarathna Beruwawela Pathiranage (San Diego, California); Habarakada Liyanachchi Prabath Arjuna Madanayake (West Miami, Florida); Josep Miquel Jornet (Needham, Massachusetts) |
| ABSTRACT | A system and corresponding method may be employed for real-time ultrabroadband wireless communications. The system comprised a plurality of in-phase and quadrature (IQ) mixers that produce, in real-time on a per-channel basis, sub-channel signals from respective analog baseband IQ signals representing respective portions of user data. The system further comprises a power combiner. The power combiner produces a multi-channel output signal by frequency multiplexing, in real-time, the sub-channel signals produced. The multi-channel output signal represents the user data in its entirety and may be a real-time, multi-GHz wireless signal. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/412451 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 27/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240164006 | Raman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chandra Raman (Atlanta, Georgia); Yorick Andeweg (Atlanta, Georgia); Alexandra Crawford (Atlanta, Georgia); Chao Li (Atlanta, Georgia); Bochao Wei (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a collimated atomic beam generator. The generator can comprise an atomic vapor chamber, a collimator plate, and an insulative adhesive layer. The atomic vapor chamber can comprise an atomic vapor source. The collimator plate can comprise a first side facing the atomic vapor chamber, an opposing second side, and a plurality of channels extending between the first side and the second side. The insulative adhesive layer can be positioned between and coupling the atomic vapor chamber to the collimator plate. The collimator plate can be configured to collimate atomic vapors generated by the atomic vapor source in the atomic vapor chamber. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/162959 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 3/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240157720 | Zlotnick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Joel Zlotnick (Arlington, Virginia); Jordan Brough (Leesburg, Virginia); Troy Eberhardt (Centreville, Virginia); Tyra McConnell (Knoxville, Maryland); Elizabeth Gil (Bristow, Virginia); Traci Moran (Rockville, Maryland) |
| ABSTRACT | A substrate is printed with front side and back side markings. The front side when viewed with reflected light includes: a first marking printed with a first gradient of two colors; a second marking printed with a second gradient of two colors; a first symbol printed with a third gradient of two colors; a second symbol printed with a fourth gradient of two colors; a third symbol printed with a fifth gradient of two colors; and a fourth symbol printed with a sixth gradient of two colors. The back side when viewed with reflected light includes: a third marking printed with the fourth gradient; a fourth marking printed with the third gradient; a fifth symbol printed with the second gradient; a sixth symbol printed with the first gradient; a seventh symbol printed with the sixth gradient; and an eighth symbol printed with the fifth gradient. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/389913 |
| CURRENT CPC | Printing Machines or Presses B41F 1/16 (20130101) B41F 7/025 (20130101) B41F 31/008 (20130101) B41F 33/0036 (20130101) Printing, Duplicating, Marking, or Copying Processes; Colour Printing, B41M 1/10 (20130101) B41M 1/14 (20130101) B41M 3/14 (20130101) B41M 3/148 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/29 (20141001) Original (OR) Class B42D 25/333 (20141001) B42D 25/342 (20141001) B42D 25/351 (20141001) B42D 25/378 (20141001) B42D 25/405 (20141001) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240163094 | Karas |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Michael Karas (Fairfax Station, Virginia) |
| ABSTRACT | A system and method for securely exchanging information between a server and an endpoint. A firewall and switch may administer connections between the endpoint and the server. The network interface of the server may send and receive information through the firewall and switch. A program task in the sever may set the network interface to be in an “on state” for a predetermined amount of time on a specific date thereby creating an active time transfer window that the network interface can receive communications from the endpoint. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/383395 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101) H04L 9/088 (20130101) Original (OR) Class H04L 9/3247 (20130101) H04L 63/029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240163251 | Karas |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Michael Karas (Fairfax Station, Virginia) |
| ABSTRACT | A system and method for securely exchanging information between a server and an endpoint. A firewall and switch may administer connections between the endpoint and the server. The network interface of the server may send and receive information through the firewall and switch. A program task in the sever may set the network interface to be in an “on state” for a predetermined amount of time on a specific date thereby creating an active time transfer window that the network interface can receive communications from the endpoint. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/383376 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/102 (20130101) H04L 63/0236 (20130101) Original (OR) Class H04L 63/1425 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240163257 | Karas |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Michael Karas (Fairfax Station, Virginia) |
| ABSTRACT | A system and method for securely exchanging information between a server and an endpoint. A firewall and switch may administer connections between the endpoint and the server. The network interface of the server may send and receive information through the firewall and switch. A program task in the sever may set the network interface to be in an “on state” for a predetermined amount of time on a specific date thereby creating an active time transfer window that the network interface can receive communications from the endpoint. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/383352 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/101 (20130101) H04L 63/0272 (20130101) Original (OR) Class H04L 63/1433 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240156783 | Mohan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | The Curators of the University of Missouri (Columbia, Missouri); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Rajiv R. Mohan (Columbia, Missouri) |
| ABSTRACT | Provided herein are compositions suitable for treating chemically induced eye damage comprising (a) a nonsteroidal anti-inflammatory drug (NSAID), (b) a histone deacetylase (HDAC) inhibitor and (c) an angiotensin converting enzyme (ACE) inhibitor and, optionally, (d) a water-soluble vitamin. Methods of using provided compositions to treat ocular toxicity and corneal damage following exposure to chemical agents (e.g., mustard gas) are also provided. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390829 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/167 (20130101) A61K 31/375 (20130101) A61K 31/401 (20130101) A61K 31/407 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240156973 | Low et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip Stewart Low (West Lafayette, Indiana); Jeffery Nielsen (Lafayette, Indiana); Melissa Ann Kacena (Zionsville, Indiana) |
| ABSTRACT | Bone-targeting therapeutic compounds and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising a bone-targeting therapeutic compound; processes for preparing bone-targeting therapeutic compounds; and therapeutic methods to treat bone defects. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 18/547837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 47/645 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158386 | DEVITA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | Robert DEVITA (New York, New York); Giulio M. PASINETTI (New York, New York); Maria SEBASTIAN-VALVERDE (New York, New York); Francis HERMAN (New York, New York); Kunal KUMAR (New York, New York) |
| ABSTRACT | Compounds which are benzoxazolone derivatives are disclosed, including compounds of the following genus: The compounds possess anti-inflammasome properties and exhibit anti-fibrotic and anti-proliferative effects. They are useful in inhibiting the activation of NLRP3 or NLRC4 receptors, and in the treatment of a variety of neuroinflammatory disorders such as autoimmune diseases, type-2 diabetes, Cryopyrin-Associated Autoinflammatory Syndromes, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and rheumatoid arthritis. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 18/548348 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Heterocyclic Compounds C07D 413/12 (20130101) C07D 413/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161301 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Nathaniel Braman (Cleveland, Ohio); Vidya Sankar Viswanathan (Shaker Heights, Ohio) |
| ABSTRACT | The present disclosure relates to a method. The method includes accessing data having one or more segmented images identifying one or more lesions and/or a plurality of blood vessels associated with the lesions. Respective ones of the blood vessels correspond to one or more centerlines and one or more constituent branches associated with the one or more lesions. The one or more segmented images are derived from one or more radiological images of a patient having cancer. One or more vascular radiology features are extracted using the centerlines, the constituent branches, and the one or more lesions. The one or more vascular radiology features relate to a quantification of the plurality of blood vessels or a shape of the plurality of blood vessels. The one or more vascular radiology features are used to determine a medical prediction associated with an outcome of the patient to cyclin-dependent kinase (CDK) inhibitor therapy. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/500473 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0016 (20130101) Original (OR) Class G06T 2207/10116 (20130101) G06T 2207/30056 (20130101) G06T 2207/30068 (20130101) G06T 2207/30096 (20130101) G06T 2207/30101 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240158104 | Dor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mehregan Dor (Atlanta, Georgia); Travis Driver (Atlanta, Georgia); Panagiotis Tsiotras (Atlanta, Georgia) |
| ABSTRACT | An exemplary system and method are disclosed for a standalone vision-based system for autonomous online navigation, e.g., around an unknown target small body. The exemplary system (also referred to as AstroSLAM) is predicated on the formulation of the SLAM problem as an incrementally growing factor graph. Using the GTSAM library and the iSAM2 engine, the exemplary system and method combine sensor fusion with the prior orbital motion to provide navigation and parameter estimation that improves the performance over a baseline SLAM implementation. The exemplary system and method can incorporate orbital motion constraints into the factor graph by devising a relative dynamics factor that can link the relative pose of the spacecraft to the problem of predicting trajectories stemming from the motion of the spacecraft in the vicinity of the small body. |
| FILED | Wednesday, November 01, 2023 |
| APPL NO | 18/499567 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/247 (20230801) Original (OR) Class B64G 3/00 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/24 (20130101) Image Data Processing or Generation, in General G06T 7/73 (20170101) G06T 2200/04 (20130101) G06T 2207/10032 (20130101) G06T 2207/30252 (20130101) Image or Video Recognition or Understanding G06V 20/56 (20220101) G06V 20/64 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240159688 | Oudrhiri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Kamal Oudrhiri (Pasadena, California); Javier Bosch-Lluis (Pasadena, California); Nereida Rodriguez Alvarez (Pasadena, California); Joan F. Munoz (Pasadena, California) |
| ABSTRACT | One embodiment includes a system for moisture content detection and surface evaluation, including a set of one or more antennas, a radiometer, a reflectometer, a set of one or more cameras, a Global Navigation Satellite System receiver, a memory containing an evaluation application, and a processor including a set of one or more processors, wherein the evaluation application configures the processors to evaluate a surface underneath the system by performing the steps of obtaining a plurality of measurements using the radiometer, the reflectometer, and the set of one or more cameras, obtaining a set of one or more observables based on the plurality of measurements; at a high spatial resolution, generating a set of one or more environmental products based on at least one observable from the set of one or more observables, and displaying the set of one or more environmental products on a graphical user interface. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508996 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240163691 | Barsoum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Constellation Designs, LLC (Wayne, Pennsylvania) |
| ASSIGNEE(S) | Constellation Designs, LLC (Wayne, Pennsylvania) |
| INVENTOR(S) | Maged F. Barsoum (San Jose, California); Christopher R. Jones (Pacific Palisades, California) |
| ABSTRACT | Communication systems are described that use signal constellations, which have unequally spaced (i.e. ‘geometrically’ shaped) points. In many embodiments, the communication systems use specific geometric constellations that are capacity optimized at a specific SNR, over the Rayleigh fading channel. In addition, ranges within which the constellation points of a capacity optimized constellation can be perturbed and are still likely to achieve a given percentage of the optimal capacity increase compared to a constellation that maximizes dmin, are also described. Capacity measures that are used in the selection of the location of constellation points include, but are not limited to, parallel decode (PD) capacity and joint capacity. |
| FILED | Wednesday, May 31, 2023 |
| APPL NO | 18/326967 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) H04L 1/0009 (20130101) H04L 5/006 (20130101) H04L 27/3405 (20130101) Wireless Communication Networks H04W 24/02 (20130101) Original (OR) Class H04W 72/0453 (20130101) H04W 72/0473 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240161295 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545542 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161296 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545550 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240161297 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545563 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240158584 | Aksoy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AUBURN UNIVERSITY (Auburn, Alabama) |
| ASSIGNEE(S) | AUBURN UNIVERSITY (Auburn, Alabama) |
| INVENTOR(S) | Burak Aksoy (Auburn, Alabama); Zhihua Jiang (Auburn, Alabama); Navid E. Alamdari (Auburn, Alabama) |
| ABSTRACT | A method of making a hydrogel by treating a cellulosic biomass containing pectin and protein with an aqueous acidic solution at a pH, at a temperature, and for a time sufficient to cause formation of at least a gel fraction containing the hydrogel. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508979 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) Original (OR) Class C08J 2305/06 (20130101) C08J 2389/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240158823 | Barney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett Barney (Minneapolis, Minnesota); Alexander James Steiner (Saint Paul, Minnesota) |
| ABSTRACT | A genetically modified diazotrophic microbe is genetically modified to produce γ-polyglutamic acid (γ-PGA). In one or more embodiments, the diazotrophic microbe is Azotobacter vinelandii. In one or more embodiments, the diazotrophic microbe is genetically modified to use a non-sugar carbon source. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506263 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 9/90 (20130101) C12N 9/93 (20130101) C12N 15/74 (20130101) C12N 2800/90 (20130101) C12N 2800/101 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/02 (20130101) Original (OR) Class Enzymes C12Y 402/01011 (20130101) C12Y 501/01003 (20130101) C12Y 603/02 (20130101) C12Y 603/02017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240156146 | Logunov |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sergey Logunov (Tver, Russian Federation) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergey Logunov (Tver, Russian Federation) |
| ABSTRACT | Invention is a patty-forming apparatus with an innovative mold. The mold is a plate which has cavities for molding products in shape of cylindrical holes with base of arbitrary shape, and it also has a distinctive feature that there is a cut in the plate which goes through these holes and which allows to move plate parts apart in the directions parallel to the plate surface. The two parts of the plate are separated when the mold is being filled with mince, and then are connected for molding the product. The technical results are: possibility to mold well shaped products from minces with very poor fluidity and reduced energy cost of molding. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 18/055704 |
| CURRENT CPC | Shaping or Working of Foodstuffs, Not Fully Covered by a Single Other Subclass A23P 30/10 (20160801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 20240158421 | Schoenfisch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark H. Schoenfisch (Chapel Hill, North Carolina); Jae Ho Shin (Chapel Hill, North Carolina); Nathan Stasko (Chapel Hill, North Carolina) |
| ABSTRACT | The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications. |
| FILED | Monday, June 05, 2023 |
| APPL NO | 18/328983 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/167 (20130101) A61K 9/5115 (20130101) A61K 31/695 (20130101) A61K 41/0042 (20130101) A61K 47/59 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 10/00 (20130101) B82Y 30/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/10 (20130101) Original (OR) Class C07F 7/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20240160666 | EKER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ADVANCED MICRO DEVICES, INC. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ALI ARDA EKER (BELLEVUE, Washington); ANTHONY T. GUTIERREZ (BELLEVUE, Washington) |
| ABSTRACT | A system includes a processor configured to iteratively, until values of a frontier vector indicate all nodes of a graph have been discovered, select a set of rows from a matrix representation of the graph based on values of the frontier vector. The set of rows includes fewer rows than the matrix representation. The processor is further configured to calculate an output vector for a current iteration as a dot product between each of the selected set of rows in the matrix representation and the frontier vector, with the output vector for the current iteration acting as the frontier vector for a next iteration and the output vector for the next iteration initialized to the frontier vector for the current iteration. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/985136 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/9024 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240158123 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | This application relates to a method and a system for building machine learning or deep learning data sets for automatically recognizing labels on items. The system may include an optical scanner configured to capture an item including one or more labels provided thereon, the item captured a plurality of times at different positions with respect to the optical scanner. The system may further include a robotic arm on which the item is disposed, the robotic arm configured to rotate the item horizontally and/or vertically such that the one or more labels of the item are captured by the optical scanner at different positions with respect to the optical scanner. The system may include a database configured to store the captured images. |
| FILED | Wednesday, January 24, 2024 |
| APPL NO | 18/421603 |
| CURRENT CPC | Labelling or Tagging Machines, Apparatus, or Processes B65C 1/02 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/00 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/26 (20130101) Displaying; Advertising; Signs; Labels or Name-plates; Seals G09F 3/0288 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240158860 | CHAKRABORTY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE AR (Fort Detrick, Maryland); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HE (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nabarun M. CHAKRABORTY (Rockville, Maryland); Sanchita P. Ghosh (North Potomac, Maryland); Aarti Gautam (North Potomac, Maryland); Raina Kumar (Ashburn, Virginia); Rasha Hammamieh (Germanton, Maryland) |
| ABSTRACT | Early diagnosis of lethal radiation is imperative, since the intervention time windows for lethally irradiated subjects are considerably short. Hence, ideal diagnostic candidates of radiation should be easily accessible, enable to inform the stress history and triage subjects unbiasedly in a time-efficient manner. Taken together, small molecules such as metabolites and microRNAs (miRNAs) from plasma are legitimate biomarker candidate for lethal radiation. Herein is described a TBI (total body irradiation) model involving minipigs exposed to radiation. Markers were observed at early, intermediate and late time periods post-radiation, and were compared to non-exposed, non-radiated miRNA's. A method and a kit for detecting time-dependent ionizing radiation exposure is described in embodiments herein. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507575 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, May 16, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240516.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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