FedInvent™ Patent Applications
Application Details for Thursday, June 13, 2024
This page was updated on Tuesday, June 18, 2024 at 02:24 PM GMT
Department of Health and Human Services (HHS)
| US 20240188843 | Huddleston et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Huddleston (Marietta, Georgia); Babak Mahmoudi (Alpharetta, Georgia) |
| ABSTRACT | In some embodiments, the systems and methods of the disclosure can efficiently and accurately classify neurodegenerative disorder(s) and/or movement disorder(s) of a subject (e.g., a patient) using at least quantitative features associated with one or more regions of interest determined from one or more sets of image data of the subject's brain. The method may include processing one or more sets of MRI image data of the subject's brain to extract one or more quantitative features for one or more regions. The one or more quantitative features may include a first quantitative and a second quantitative feature. The method may further include classifying at least the one or more quantitative features into one or more classes associated with neurodegenerative dementia disorder, neurodegenerative movement disorder, non-neurodegenerative movement disorder and/or heathy control. The method may include generating a report including a classification of at least the one or more quantitative features. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/583373 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) Original (OR) Class A61B 5/4082 (20130101) A61B 5/7264 (20130101) A61B 5/7267 (20130101) A61B 2576/026 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) Electric Digital Data Processing G06F 18/2431 (20230101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10088 (20130101) G06T 2207/30016 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 15/00 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240188886 | Rosen et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Gary Rosen (Los Angeles, California); Susan Luczak (Los Angeles, California); Chunming Wang (Los Angeles, California); Jay Bartroff (Los Angeles, California); Larry Goldstein (Los Angeles, California) |
| ABSTRACT | System, method and application that obtains, consolidates, and integrates multiple sources of data including Transdermal Alcohol Concentration (TAC) along with drinking diary, photo/video, breath analyzer, other biological data (e.g., heart rate, skin conductance. blood flow, person-level biometrics), and environmental data (e.g., ambient temperature, humidity, GPS) and uses models described herein to convert TAC obtained from a wearable biosensor into estimated Blood Alcohol Concentration (BAC) or Breath Alcohol Concentration (BrAC). |
| FILED | Friday, February 04, 2022 |
| APPL NO | 18/275108 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4845 (20130101) Original (OR) Class A61B 5/6801 (20130101) A61B 5/7264 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240188927 | Yarmush et al. |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
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| INVENTOR(S) | Martin L. Yarmush (Newton, Massachusetts); Alvin Chen (Cambridge, Massachusetts); Max Balter (Boston, Massachusetts); Joshua Leipheimer (Highland Park, New Jersey) |
| ABSTRACT | A device and method for directing a cannula toward a target location under a patient's skin. The device is handheld and the device operations may be automated. The device includes an imaging probe for imaging the target location, a positioning unit for manipulating a cannula towards the target location, and a processor. The processor receives imaging data from the imaging probe, cannula pose data from at least one cannula position sensor, and device pose data from at least one device position sensor. The target location is identified from the imaging data, and a trajectory for manipulating the cannula towards the target location is determined based on the imaging data, the cannula pose data, and the device pose data. The processor may determine that the trajectory becomes misaligned with the target position, and may update to a corrected trajectory based on the imaging data, cannula pose data, and device pose data. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/586675 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/12 (20130101) A61B 8/466 (20130101) A61B 8/0841 (20130101) Original (OR) Class A61B 8/4218 (20130101) A61B 2034/2065 (20160201) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189090 | SICOTTE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Zenflow, Inc. (Palo Alto, California) |
| ASSIGNEE(S) | Zenflow, Inc. (Palo Alto, California) |
| INVENTOR(S) | Marcel Song SICOTTE (San Francisco, California); Austin Michael BLY (San Clemente, California); Ben COLLETT-NYE (Kumeu, New Zealand); Shreya MEHTA (San Francisco, California) |
| ABSTRACT | Systems, devices, and methods are provided for the delivery of an implant into the prostatic urethra. Embodiments of delivery systems can include a delivery device for insertion into the patient and a proximal control device for use in controlling release of the implant from the delivery device. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/444381 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3468 (20130101) A61B 2017/00274 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/042 (20130101) Original (OR) Class A61F 2/885 (20130101) A61F 2/966 (20130101) A61F 2002/047 (20130101) A61F 2250/001 (20130101) Gearing F16H 1/06 (20130101) F16H 1/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189220 | VARMA et al. |
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| APPLICANT(S) | PHI THERAPEUTICS, INC. (San Francisco, California) |
| ASSIGNEE(S) | PHI THERAPEUTICS, INC. (San Francisco, California) |
| INVENTOR(S) | Yug VARMA (San Francisco, California); Nancy VAN PROOYEN (San Francisco, California) |
| ABSTRACT | Provided herein are, inter alia, compositions, systems, and methods for preventing or treating acne. Included are compositions, combinations, systems, and methods comprising at least one Propionibacterium acnes bacteriophage, at least one anti-acne compound, and a pharmaceutically acceptable carrier. Also included are compositions, combinations, and systems comprising a Propionibacterium acnes bacteriophage and an enzyme. Methods for preventing or treating acne are also provided. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413988 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/05 (20130101) A61K 31/60 (20130101) A61K 31/327 (20130101) A61K 33/04 (20130101) A61K 35/76 (20130101) Original (OR) Class A61K 35/741 (20130101) A61K 38/47 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/10 (20180101) Enzymes C12Y 302/01052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189247 | Joung et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
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| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Peter Cabeceiras (Boston, Massachusetts) |
| ABSTRACT | Described herein are virus-like particles (VLPs) and minimal human-derived virus-like particles (mhVLPs), comprising a membrane comprising a phospholipid bilayer with one or more human-derived envelope glycoproteins (env) on the external side. Optionally, a biomolecule cargo is disposed in the core of the VLP or mhVLP on the inside of the membrane. Preferably, the mhVLPs do not comprise any exogenous virally derived proteins, e.g., proteins from viral gag, pro, or pol, or other viral proteins that reside inside of enveloped particles (unless the cargo comprises the viral protein(s)). In some embodiments, the mhVLPs do not comprise any human endogenous retroviral (HERV) proteins other than the env (hENV), e.g., do not comprise gag, pol, or pro that was exogenously introduced into producer cells. In some embodiments, the VLPs include a targeting domain, either fused at the N or C terminus or internally into the hENV, or as a separate membrane-anchored targeting domain. Also described are methods of use of the VLPs or mhVLPs for delivery of the biomolecule cargo to cells. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511486 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5184 (20130101) Original (OR) Class A61K 9/5192 (20130101) A61K 48/0033 (20130101) Peptides C07K 14/005 (20130101) C07K 14/47 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2740/10022 (20130101) C12N 2740/10023 (20130101) C12N 2740/10043 (20130101) C12N 2740/10052 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189261 | Wellman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
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| INVENTOR(S) | D. Andrew Wellman (Wayland, Massachusetts); Luigi Taranto-Monternurro (Chestnut Hill, Massachusetts) |
| ABSTRACT | Methods and compositions for the treatment of conditions associated with pharyngeal airway muscle collapse while the subject is in a non-fully conscious state, e.g., sleep apnea and snoring, comprising administration of a norepinephrine reuptake inhibitor (NRI) and a muscarinic receptor antagonist. |
| FILED | Wednesday, July 19, 2023 |
| APPL NO | 18/355178 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 31/216 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189276 | Sharma et al. |
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| APPLICANT(S) | Southwestern Oklahoma State University (Weatherford, Oklahoma) |
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| INVENTOR(S) | Horrick Sharma (Weatherford, Oklahoma); Pragya Sharma (Weatherford, Oklahoma) |
| ABSTRACT | Compounds that incorporate a succinic acid scaffold are disclosed that inhibit Lactate dehydrogenase-A (LDHA). Also disclosed are pharmaceutical compositions containing these compounds. In addition, methods of using these compounds in methods of inhibiting LDHA expression and/or enzymatic activity in cells and methods of reducing viability of cancer cells are disclosed. Also disclosed are methods of treating a subject in need thereof with the pharmaceutical compositions containing one or more LDHA-inhibiting compounds. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/060323 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4025 (20130101) Original (OR) Class A61K 31/4155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189277 | Ensign et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
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| INVENTOR(S) | Laura Ensign (Baltimore, Maryland); Justin Hanes (Baltimore, Maryland); Yoo Chun Kim (Baltimore, Maryland); Tung Heng Hsueh (Baltimore, Maryland) |
| ABSTRACT | Administration of therapeutic, prophylactic, or diagnostic agents that bind to a receptor or ligand in the eye or to the skin in microcrystalline form leads to increased delivery and long-lasting activity within the eye as compared with administration of the agent in non-crystalline form. Compositions and methods for delivery of active agents in microcrystalline form to the eye for the treatment, prevention and diagnosis of eye diseases and disorders are provided. In preferred embodiments, microcrystals include sunitinib malate in complex with pamoic acid. Administration of microcrystals of sunitinib malate/pamoic acid to the eye provides protection from glaucoma for up to 6 months or longer without retinal toxicity, following a single injection into the eye. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 18/554928 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 31/192 (20130101) A61K 31/404 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189278 | Plante et al. |
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| APPLICANT(S) | Klotho Therapeutics, Inc. (Las Vegas, Nevada) |
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| INVENTOR(S) | James Plante (Las Vegas, Nevada); William Ramage (Del Mar, California); Michael Bishop (San Diego, California) |
| ABSTRACT | Compositions and methods for the treatment and amelioration of arterial stiffness, hypertension, and/or arterial aging in a subject. In embodiments, the active agents of the compositions provide anti-aging treatments by causing arterial remodeling by decreasing collagen production and increasing elastin production in a subject. In certain embodiments, the active agents can be used to treat a subject having diabetes or a diabetes-related disease or condition, such as but not limited to, Type 1 diabetes mellitus (T1DM), Type 2 diabetes mellitus (T2DM), and hyperinsulenima (pre-diabetes). In certain embodiments, the active agents can be used to treat subjects having hypertension, aortic disease, cardiovascular disease, including heart failure (such as congestive heart failure), kidney disease, osteoporosis, Alzheimer's disease, infertility, and emphysema. |
| FILED | Monday, June 05, 2023 |
| APPL NO | 18/206076 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4045 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189291 | Murray et al. |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
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| INVENTOR(S) | Katherine T. Murray (Nashville, Tennessee); L Jackson Roberts, II (Nashville, Tennessee); Venkataraman Amarnath (Nashville, Tennessee) |
| ABSTRACT | Methods and compositions for use in treating atrial fibrillation in a subject. The compounds of the present invention are gamma-ketoaldehyde scavengers. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/414316 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) Original (OR) Class A61K 31/135 (20130101) A61K 31/137 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/4415 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189303 | Stokes |
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| APPLICANT(S) | University of Hawaii (Honolulu, Hawaii) |
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| INVENTOR(S) | Alexander Stokes (Honolulu, Hawaii) |
| ABSTRACT | Methods are provided of treating cardiac hypertrophy in a mammalian subject comprising administering to the subject an anti-hypertrophic effective amount of an ion channel TR-PV1 inhibitor. The methods include treatment of a symptom of cardiac hypertrophy in the subject comprises cardiac remodeling, cardiac fibrosis, apoptosis, hypertension, or heart failure |
| FILED | Thursday, September 07, 2023 |
| APPL NO | 18/243572 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/497 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189304 | Gao et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Ohio State Innovation Foundation (Columbus, Ohio); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Allen C. Gao (Davis, California); Pui-Kai Li (Columbus, Ohio); Mark Foster (Columbus, Ohio); Ross Larue (Columbus, Ohio); Cameron M. Armstrong (Davis, California); Wei Lou (Davis, California); Shu Ning (Davis, California); Enming Xing (Columbus, Ohio) |
| ABSTRACT | Methods for the treatment of condition associated with bromodomain and extraterminal domain (BET) protein activity are disclosed. The methods include administering a therapeutically effective amount of a piperazine BET protein inhibitor or a piperidine BET protein inhibitor to a subject in need thereof. Piperazine BET protein inhibitors, piperidine BET protein inhibitors, and pharmaceutical compositions comprising the BET proteins inhibitors are also described. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 18/548844 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4166 (20130101) A61K 31/4439 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/12 (20130101) C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189335 | PAINTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
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| INVENTOR(S) | George R. PAINTER (Atlanta, Georgia); Gregory R. BLUEMLING (Decatur, Georgia); Michael G. NATCHUS (Alpharetta, Georgia); David GUTHRIE (Avondale Estates, Georgia) |
| ABSTRACT | This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390347 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7068 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189347 | Liechty et al. |
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| APPLICANT(S) | The Regents of the University of Colorado, A Body Corporate (Denver, Colorado); University of Central Florida Research Foundation, Inc. (Orlando, Florida); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Liechty (Aurora, Colorado); Sudipta Seal (Orlando, Florida); Robert Gorman (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following injury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, preventing adverse ventricular remodeling following myocardial infarction. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/503969 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/14 (20130101) A61K 9/0019 (20130101) A61K 31/728 (20130101) A61K 33/24 (20130101) Original (OR) Class A61K 47/55 (20170801) A61K 47/549 (20170801) A61K 47/6923 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/235 (20200101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2310/351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189351 | Puri et al. |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept.of Health and Human Services (Silver Spring, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Silver Spring, Maryland) |
| INVENTOR(S) | Raj K. Puri (Urbana, Maryland); Bharatkumar H. Joshi (Rockville, Maryland) |
| ABSTRACT | Immunotherapies, particularly chimeric antigen receptors targeting IL-13Rα2 and their use for treating cancer are provided. A single chain fragment variable (scFv) that specifically binds IL-13Rα2, chimeric antigen receptors (CARs) including the IL-13Rα2 scFv, nucleic acids encoding the CARs, vectors including the nucleic acids encoding the CARs, and immune cells expressing the CARs are provided. Also provided are methods of treating a subject with cancer, including administering to the subject an immune cell expressing an IL-13Rα2 scFv-CAR alone or in combination with other cancer therapies. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 18/285218 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464419 (20230501) A61K 45/06 (20130101) A61K 2239/13 (20230501) A61K 2239/17 (20230501) A61K 2239/21 (20230501) A61K 2239/22 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2866 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189363 | Lee et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard T. Lee (Cambridge, Massachusetts); Jessica Garbern (Brookline, Massachusetts); Douglas A. Melton (Cambridge, Massachusetts); Aharon Helman (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are methods for generating mature cardiomyocytes and compositions including mature cardiomyocytes. Also disclosed herein are methods for enhancing maturation of quiescent cardiomyocytes and compositions including mature quiescent cardiomyocytes. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/508057 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Original (OR) Class A61K 38/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189384 | Urish et al. |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Urish (Sewickley, Pennsylvania); Jonathan Brendan Mandell (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of treating or preventing a microbial infection in a patient is provided, along with a wound irrigation system and a composition in the form of an irrigation liquid for reducing microbial load or preventing microbial infection in a wound. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/587268 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/546 (20130101) A61K 38/10 (20130101) Original (OR) Class A61K 38/1729 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189395 | Fan et al. |
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| APPLICANT(S) | UNIVERSITY OF MISSISSIPPI MEDICAL CENTER (Jackson, Mississippi) |
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| INVENTOR(S) | Lir-Wan Fan (Brandon, Mississippi); Abhay Jyotindrabhai Bhatt (Ridgeland, Mississippi) |
| ABSTRACT | A method for treating or reducing a likelihood of hypoxia-ischemia induced brain damage and neurobehavioral dysfunction in neonates utilizes a relative high dose of nasally administered insulin. In one aspect, the method includes intranasally administering, to a neonate in need thereof, an effective dose of insulin comprising between 350 U to 2000 U insulin. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584727 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 38/28 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189414 | KIM et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vernagen, LLC (Tucker, Georgia); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | Vernagen, LLC (Tucker, Georgia); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Baek KIM (Atlanta, Georgia); Jack Yoon (Suwanee, Georgia); David Pak (Suwanee, Georgia); Claire Yuhui Huang Kinney (Fort Collins, Colorado) |
| ABSTRACT | Provided herein are a Heartland virus vaccine composition including a messenger ribonucleic acid (mRNA) including an open reading frame (ORF) encoding Gn or Gc of Heartland virus, a Heartland virus vaccine composition comprising a messenger ribonucleic acid (mRNA) comprising an open reading frame (ORF) encoding Gn or Gc of Heartland virus fused with human collagen type I alpha 1 (COL1A1) signal peptide, and a method of inducing immune response against Heartland virus by administering an effective amount of the Heartland virus vaccine composition to a subject in need thereof. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530861 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 39/12 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189415 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baozhong Wang (Duluth, Georgia); Chunhong Dong (Atlanta, Georgia) |
| ABSTRACT | Disclosed are functionalized graphene oxide nanoparticles and methods their use in inhibiting and treating microbial infection. The disclosure herein further provides for methods of making functionalized graphene oxide nanoparticles and said nanoparticles further incorporating microbial antigens for inducing antigen specific immune responses. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/286191 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/575 (20130101) A61K 2039/55555 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16134 (20130101) C12N 2760/16171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189423 | WELLS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. WELLS (San Francisco, California); Katarina PANCE (San Francisco, California); Josef A. GRAMESPACHER (San Francisco, California); Kaan Kumru (San Francisco, California) |
| ABSTRACT | The present disclosure relates to targeted degradation platform technology. For example, the present disclosure relates to bispecific binding agents for degrading endogenous proteins, whether membrane-associated or soluble, using the lysosome pathway. The disclosure also provides methods useful for producing such agents, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various disorders. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 18/553447 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4612 (20230501) A61K 39/4633 (20230501) A61K 39/4644 (20230501) Original (OR) Class A61K 47/6851 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/48 (20130101) C07K 14/49 (20130101) C07K 14/50 (20130101) C07K 14/51 (20130101) C07K 14/53 (20130101) C07K 14/55 (20130101) C07K 14/56 (20130101) C07K 14/57 (20130101) C07K 14/61 (20130101) C07K 14/65 (20130101) C07K 14/475 (20130101) C07K 14/495 (20130101) C07K 14/505 (20130101) C07K 14/521 (20130101) C07K 14/525 (20130101) C07K 14/565 (20130101) C07K 14/575 (20130101) C07K 14/5403 (20130101) C07K 14/5406 (20130101) C07K 14/5409 (20130101) C07K 14/5412 (20130101) C07K 14/5418 (20130101) C07K 14/5425 (20130101) C07K 14/5431 (20130101) C07K 14/5434 (20130101) C07K 14/5437 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) C07K 2317/31 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189440 | TUMEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| INVENTOR(S) | Lawrence Nathan TUMEY (Vestal, New York); Emmanuel OLAWODE (El Mirage, Arizona) |
| ABSTRACT | Disclosed herein are compounds of the Formula (I) or (II) or (III): Also disclosed are methods for stimulating an immune response, inducing an anti-tumor immune response, and treating an infectious disease in a subject by administering a therapeutically effective amount of a compound disclosed herein. Also disclosed are methods of treating a tumor or abnormal cell proliferation by administering a therapeutically effective amount of a compound disclosed herein under conditions effective to treat a tumor or abnormal cell proliferation. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 18/547594 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) Original (OR) Class A61K 47/6855 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189445 | Marcos Contreras et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drew WEISSMAN (Wynnewood, Pennsylvania); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oscar Marcos Contreras (Wynnewood, Pennsylvania); Patrick Glassman (Lafayette Hill, Pennsylvania); Jia Nong (Philadelphia, Pennsylvania); Jacob Brenner (Philadelphia, Pennsylvania); Vladimir Muzykantov (Bryn Athyn, Pennsylvania); Drew Weissman (Wynnewood, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions comprising a delivery vehicle for delivery of a therapeutic agent for the treatment of a neurological disorder conjugated to a targeting domain, wherein the targeting domain specifically binds to an endothelial marker. The invention also relates to methods of treating or preventing neurological conditions using the described compositions. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 18/550000 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5192 (20130101) A61K 31/137 (20130101) A61K 31/145 (20130101) A61K 31/222 (20130101) A61K 31/366 (20130101) A61K 31/506 (20130101) A61K 31/573 (20130101) A61K 31/4422 (20130101) A61K 45/06 (20130101) A61K 47/6913 (20170801) Original (OR) Class A61K 47/6935 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 29/00 (20180101) Peptides C07K 16/2821 (20130101) C07K 16/2836 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189451 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Grainesville, Florida) |
| INVENTOR(S) | Mei He (Gainesville, Florida); Xiaoshu Pan (Gainesville, Florida) |
| ABSTRACT | Provided herein are compositions and methods useful in the treatment of hearing loss diseases, such as by correction of mutations in genes associated with hearing. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 18/286450 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5063 (20130101) A61K 47/26 (20130101) A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/88 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189455 | Choudhary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav Choudhary (Providence, Rhode Island); Peng Zhang (Providence, Rhode Island) |
| ABSTRACT | Disclosed are nucleic acid sequences comprising a cardiomyocyte-specific, cardiac stress-induced promoter operably linked to a mitochondrial targeting sequence (MTS) and/or a gene of interest. Disclosed are vectors comprising one or more of the disclosed nucleic acids. Disclosed are methods of using the disclosed nucleic acid sequences or vectors for treating a subject in need thereof. Disclosed are methods of treating pulmonary hypertension (PH) in a subject comprising administering a therapeutically effective amount of a vector to the subject, wherein the vector comprises a nucleic acid sequence comprising a cardiomyocyte-specific, cardiac stress-induced promoter operably linked to a mitochondrial targeting sequence (MTS) and/or a gene that encodes a PH therapeutic, wherein the PH therapeutic is expressed in cardiomyocytes undergoing cardiac stress. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/533784 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 9/1029 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2840/007 (20130101) Enzymes C12Y 203/01016 (20130101) C12Y 207/10002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189458 | TABOR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas); Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas); Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Jeffrey TABOR (Houston, Texas); Omid VEISEH (Houston, Texas); Robert BRITTON (Houston, Texas); Moshe BARUCH (Houston, Texas); Annie GOODWIN (Houston, Texas); Elena MUSTEATA (Houston, Texas); Michael DOERFERT (Houston, Texas); Samira AGHLARA-FOTOVAT (Houston, Texas); Maxwell HUNT (Houston, Texas) |
| ABSTRACT | The present disclosure provides compositions comprising encapsulated engineered bacteria. The bacteria may be engineered to act as sensors of biomarkers, such as inflammation, as well as to produce diagnostic or therapeutic agents. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 18/570949 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/4808 (20130101) A61K 9/5015 (20130101) A61K 9/5036 (20130101) A61K 9/5094 (20130101) A61K 9/5115 (20130101) A61K 35/74 (20130101) A61K 49/0008 (20130101) Original (OR) Class A61K 49/0091 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) C12N 11/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189481 | MURRY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Charles E. MURRY (Seattle, Washington); Michael REGNIER (Seattle, Washington); Hans REINECKE (Seattle, Washington); Xiulan YANG (Seattle, Washington); Dasom YOO (Seattle, Washington) |
| ABSTRACT | Described herein are compositions and methods relating to the improvement of cardiac function. Various embodiments relate to transplant compositions comprising cardiomyocytes which are engineered to be non-contractile, and to methods of using such cardiomyocytes or transplant compositions to improve cardiac function, e.g., by administering them to cardiac tissue. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 18/553941 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/3826 (20130101) Original (OR) Class A61L 2400/06 (20130101) A61L 2430/20 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189624 | OLCOTT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RefleXion Medical, Inc. (Hayward, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Demetri OLCOTT (Los Gatos, California); Angela Jane DA SILVA (Danville, California); Shiyu XU (San Ramon, California); Lingxiong SHAO (Saratoga, California) |
| ABSTRACT | Disclosed herein are methods and dose metrics for evaluating the performance and/or quality of a radiotherapy treatment plan and/or radiotherapy system. Dose metrics may be used in a quality assurance (QA) procedure to evaluate (e.g., test, confirm, validate, etc.) the quality of a treatment plan and/or radiotherapy system before radiation is delivered to a patient. One example of a dose metric is a coverage margin metric. The coverage margin metric may provide a way to quantify how tumor motion affects dose coverage and facilitate the determination of whether the tumor contour defined in the treatment plan has a margin that is sufficient to compensate for tumor motion and/or positional changes during radiation therapy. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/424533 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1039 (20130101) A61N 5/1071 (20130101) A61N 5/1075 (20130101) Original (OR) Class A61N 2005/1041 (20130101) A61N 2005/1076 (20130101) A61N 2005/1095 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189797 | Zhou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Donaldson Company, Inc. (Bloomington, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinxiang Zhou (Greenville, South Carolina); Graham Temples (Greenville, South Carolina); Daniel Henn (Wilmington, Delaware) |
| ABSTRACT | Separation media includes a support substrate and a plurality of separation ligands immobilized on the support substrate. The plurality of separation ligands include an affinity capable of recognizing and binding to a carbohydrate recognizing domain. Methods of making the separation media and methods of using the separation media are disclosed. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/383453 |
| CURRENT CPC | Separation B01D 15/3828 (20130101) B01D 2221/10 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/24 (20130101) B01J 20/223 (20130101) B01J 20/289 (20130101) B01J 20/3206 (20130101) B01J 20/3265 (20130101) Original (OR) Class B01J 2220/44 (20130101) B01J 2220/52 (20130101) Peptides C07K 1/22 (20130101) C07K 14/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189820 | Robles Guerrero et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cellia Science, Inc. (Fayetteville, Arkansas); Gener8 LLC (San Jose, California); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francisco E. Robles Guerrero (Atlanta, Georgia); Jiyang Mei (San Diego, California); Kelly Marie Pollock Mabry (Redwood City, California) |
| ABSTRACT | The present invention is directed to systems, methods, and apparatus for an improved microfluidic cell imaging system that allows for the simultaneous application of a compression force to a biological specimen forming a consistent cell monolayer while imaging the cells. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/533935 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/025 (20130101) B01L 2200/0663 (20130101) B01L 2300/0654 (20130101) B01L 2300/0816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189822 | Crist et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Crist (Wayzata, Minnesota); David Wood (Minneapolis, Minnesota); Michael C. McAlpine (Minneapolis, Minnesota); Ruitao Su (Allston, Massachusetts) |
| ABSTRACT | The describes example systems, devices, and techniques. In one example, a device includes a body extending away from a substrate, which includes a first end with an open-facing port configured to allow introduction of a tissue sample, and a second end that forms an open outlet proximal the major surface of the substrate. At least a portion of the body includes therein a tissue chamber for the tissue sample. At least one microfluidic channel on the major surface of the substrate is fluidly connected to the tissue chamber, and includes an inlet upstream of the tissue chamber and an outlet downstream of the tissue chamber. A separation element is between the tissue chamber and the at least one microfluidic channel. The tissue chamber, the separation element and the microfluidic channel occupy a single layer on the substrate. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 18/556529 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/16 (20130101) B01L 2300/087 (20130101) B01L 2300/0654 (20130101) B01L 2300/0874 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) C12M 25/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190735 | Jaffé et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter R. Jaffé (Princeton, New Jersey); Bruce E. Koel (Princeton, New Jersey) |
| ABSTRACT | Media are described herein for the degradation and/or remediation of ammonium, ammonium containing contaminants and/or fluorochemicals. A medium, in some embodiments, comprises an electron donor, an electron acceptor comprising iron particles having a polymeric coating, and a Feammox bacterium and/or one or more enzymes capable of oxidizing the electron donor coupled with reduction of Fe(III) of the iron particles to Fe(II). The electron donor, in some embodiments, comprises ammonium, an ammonium containing compound, and/or molecular hydrogen. The medium, in some embodiments, further comprises a fluorochemical component, and the Feammox bacterium and/or one or more enzymes exhibit reductive dehalogenase activity capable of fluorochemical degradation in conjunction with oxidation of the electron donor and electron transfer to the electron acceptor. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/533781 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/72 (20130101) Original (OR) Class C02F 2101/16 (20130101) C02F 2305/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190817 | Bellacosa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Institute For Cancer Research D/B/A The Research Institute of Fox Chase Cancer Center (PHILADELPHIA, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfonso Bellacosa (Philadephia, Pennsylvania); John Karanicolas (Philadephia, Pennsylvania); Timothy J. Yen (Philadephia, Pennsylvania); Michael Cory (Philadephia, Pennsylvania); Chris Parry (Philadephia, Pennsylvania); Rahul Prasad (Philadephia, Pennsylvania) |
| ABSTRACT | Phenylsulfonamido compounds that inhibit genome-wide hypomethylation and can be used to treat cancer, including melanoma, prostate cancer, pancreatic cancer, breast cancer, colon cancer, lung cancer, ovarian cancer, and glioblastoma, are provided. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 18/043548 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/4439 (20130101) Acyclic or Carbocyclic Compounds C07C 311/21 (20130101) Original (OR) Class Heterocyclic Compounds C07D 401/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190828 | Shishodia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shifali Shishodia (Milwaukee, Wisconsin); Christopher J. Goetz (Wauwatosa, Wisconsin); Michael D. Olp (Milwaukee, Wisconsin); Brian Christopher Smith (Elm Grove, Wisconsin) |
| ABSTRACT | The present disclosure provides novel inhibitors of PBRM1, specifically the 2nd bromodomain of PBRM1 (PBRM1-BD2), pharmaceutical compositions and methods of use thereof. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/546143 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 229/58 (20130101) C07C 251/24 (20130101) Heterocyclic Compounds C07D 219/06 (20130101) C07D 239/91 (20130101) Original (OR) Class C07D 265/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190838 | Brognard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | John F. Brognard (Middletown, Maryland); Rolf E. Swenson (Silver Spring, Maryland); Amy L. Funk (Frederick, Maryland); Carolyn W. Hitko (Olney, Maryland); Katherine M. Nyswaner (Keedysville, Maryland); Eric Lindberg (Rockville, Maryland); Venkatareddy Sabbasani (Monrovia, Maryland); Knickole L. Bergman (Jefferson, Maryland) |
| ABSTRACT | Leucine zipper-bearing kinase (LZK) targeted degraders are disclosed. The compounds have a general formula Q-L-Z where Q is an LZK binding moiety, L is a linker, and Z is an E3-ligase binding moiety. The compounds inhibit LZK activity and/or degrade LZK. The compounds may be used to treat diseases or conditions characterized at least in part by LZK overexpression. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176849 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4439 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190872 | HERGENROTHER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | Paul J. HERGENROTHER (Champaign, Illinois); Erica Nicole PARKER (Urbana, Illinois); Deborah HUNG (Cambridge, Massachusetts); Michael SERRANO-WU (Belmont, Massachusetts); Katie Kyungae LEE (Boston, Massachusetts) |
| ABSTRACT | A FabI inhibitor called fabimycin that has impressive activity against >200 clinical isolates of E. coli, K. pneumoniae, and A. baumannii. Fabimycin has activity in multiple mouse models of infection caused by Gram-negative bacteria, including a model of urinary tract infection. Fabimycin has translational promise, and its discovery provides data indicating that antibiotics whose spectrum of activity is restricted to Gram-positive bacteria can be systematically modified to accumulate in Gram-negative bacteria and be effective against these problematic pathogens. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 18/548580 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0073 (20130101) A61K 9/2013 (20130101) A61K 9/2018 (20130101) A61K 9/2027 (20130101) A61K 9/2054 (20130101) A61K 9/2059 (20130101) A61K 9/4858 (20130101) A61K 9/4866 (20130101) A61K 47/02 (20130101) A61K 47/06 (20130101) A61K 47/10 (20130101) A61K 47/12 (20130101) A61K 47/14 (20130101) A61K 47/18 (20130101) A61K 47/26 (20130101) A61K 47/32 (20130101) A61K 47/38 (20130101) A61K 47/44 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 471/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190874 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shaomeng Wang (Superior Township, Michigan); Lijie Zhao (Ann Arbor, Michigan); Xin Han (Ann Arbor, Michigan); Weiguo Xiang (Ypsilanti, Michigan) |
| ABSTRACT | The present disclosure provides compounds of Formula (I): and the salts or solvates thereof, wherein A1, B1, L, and X2 are as defined in the specification. The present disclosure also relates to uses of the compounds, e.g., as androgen receptor degraders useful for the treatment of diseases (e.g., cancer). |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/279229 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/438 (20130101) Heterocyclic Compounds C07D 471/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190877 | JANDA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kim D. JANDA (La Jolla, California); Nicholas T. JACOB (San Diego, California); Jonathan W. LOCKNER (San Diego, California) |
| ABSTRACT | There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of Formula I herein. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/391420 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Heterocyclic Compounds C07D 471/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190912 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Donaldson Company, Inc. (Bloomington, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinxiang Zhou (Greenville, South Carolina); Graham Temples (Greenville, South Carolina); Daniel Henn (Wilmington, Delaware) |
| ABSTRACT | Separation media includes a support substrate and a plurality of separation ligands immobilized on the support substrate. The plurality of separation ligands include an affinity group capable of binding to a carbohydrate. Methods of making the separation media and methods of using the separation media are disclosed. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/383444 |
| CURRENT CPC | Separation B01D 15/3809 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/289 (20130101) B01J 20/3265 (20130101) Peptides C07K 1/22 (20130101) Original (OR) Class C07K 14/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190927 | SCHNEEWIND et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| INVENTOR(S) | Olaf SCHNEEWIND (Chicago, Illinois); Alice G. CHENG (Boston, Massachusetts); Dominique M. MISSIAKAS (Chicago, Illinois); Hwan Keun Kim (Chicago, Illinois) |
| ABSTRACT | The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/583180 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/085 (20130101) A61K 2039/57 (20130101) Peptides C07K 14/31 (20130101) Original (OR) Class C07K 16/1271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190930 | ARORA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paramjit S. ARORA (Cold Spring Harbor, New York); Michael G. WUO (Brooklyn, New York) |
| ABSTRACT | This invention relates to macrostructures (and pharmaceutical formulations containing them) that include a parallel coiled-coil structure, wherein the parallel coiled-coil comprises a first coil of Formula I and a second coil of Formula II: T1-f0-g0-a1-b1-c1-d1-e1-f1-g1-a2-b2-C2-d2-e2-f2-g2-a3-b3-c3-d3-e3-T2 (I) T3-g′0-a′1-b′1-c′1-d′1-e′1-f′1-g′1-a′2-b′2-c′2-d′2-f′2-g′2-a′3-b′3-c′3-d′3-f′3-T4 (II), as described in the present application. Methods of using these macrostructures are also disclosed. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541907 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) A61K 47/65 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 49/04 (20130101) Heterocyclic Compounds C07D 227/02 (20130101) C07D 255/02 (20130101) C07D 333/02 (20130101) Peptides C07K 7/02 (20130101) C07K 7/08 (20130101) C07K 14/4702 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190937 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Qing-Rong Liu (Perry Hall, Maryland); Min Zhu (Phoenix, Maryland); Pingbo Zhang (Columbia, Maryland); Josephine M. Egan (Bethesda, Maryland) |
| ABSTRACT | Methods of treating a subject with diabetes or Alzheimer's disease with a disclosed insulin isoform or Cα polypeptide are provided. Methods of detecting insulin isoforms or Cα polypeptides are also provided. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 18/287630 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 25/28 (20180101) Peptides C07K 14/62 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/62 (20130101) G01N 2800/044 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190940 | Robbins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Serice (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Serice (Bethesda, Maryland) |
| INVENTOR(S) | Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland); Gabriel D. Ivey (Washington, District of Columbia); Almin Lalani (North Bethesda, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glutamine at position 61 with lysine. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 18/286911 |
| CURRENT CPC | Peptides C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/10043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190965 | Kim |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tae Kon Kim (Nashville, Tennessee) |
| ABSTRACT | As disclosed herein, (1) PD-1H is significantly up-regulated in human AML BM while PD-L1 expression is relatively low; (2) PD-1H is highly expressed on human AML blasts but not on normal CD34+ progenitors; (3) PD-1H expressed on AML blasts contributes to the induction of immune evasion in murine AML models; (4) genetic ablation or antibody blockade of PD-1H reverses immune evasion, leading to anti-leukemia effects in murine AML models and humanized AML models; (5) the effect of anti-PD-1H mAb could be maximized by blocking the PD pathway in murine AML models and humanized AML models. Therefore, disclosed herein is a method for treating a leukemia in a subject that involves co-administering to the subject a therapeutically effective amount of a checkpoint inhibitor and a therapeutically effective amount of an antibody that specifically binds PD-1H. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/531168 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 16/2818 (20130101) Original (OR) Class C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190985 | KOIDE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shohei KOIDE (New York, New York); Christopher P. PARK (New York, New York); Larizbeth A. ROMERO (Yonkers, New York); Takamitsu HATTORI (West New York, New Jersey) |
| ABSTRACT | The present disclosure relates to an antibody-based molecule that binds CD99. This antibody-based molecule comprises a heavy chain variable region having: (i) a complementarity—determining region 1 (CDR-H1) comprising an amino acid sequence of any one of SEQ ID NOs: 1-3, or a modified amino acid sequence of any one of SEQ ID NOs: 1-3; (ii) a complementarity—determining region 2 (CDR-H2) comprising an amino acid sequence of any one of SEQ ID NOs: 4-10, or a modified amino acid sequence of any one of SEQ ID NOs: 4-10; and/or (iii) a complementarity—determining region 3 (CDR-H3) comprising an amino acid sequence of any one of SEQ ID NOs: 11-14, or a modified amino acid sequence of any one of SEQ ID NO: 11-14. Also disclosed are isolated polynucleotides encoding the antibody-based molecules, vectors comprising said isolated polynucleotides, as well as pharmaceutical compositions comprising the same and methods of use thereof. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/555353 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/52 (20130101) C07K 2317/73 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190988 | Birnbaum et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael Birnbaum (Arlington, Massachusetts); Taeyoon Kyung (Chelsea, Massachusetts) |
| ABSTRACT | Provided herein are chimeric antigen receptor (CAR) viral libraries and methods of making the same. In some embodiments, the CAR comprises an intracellular domain (ICD) with at least one immune activation signaling domain, one co-stimulatory domain, and one or more inhibitory signaling domain or signaling domain from non-T cell lineages. In some embodiments, the signaling domains of the ICD are joined by distinct linkers of 10 amino acids. In some embodiments, the CARs contain a 18-nucleotide barcode in the 3′ untranslated region. Also provided herein, are CAR cell libraries and methods of making the same. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505606 |
| CURRENT CPC | Peptides C07K 16/30 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) C07K 2319/033 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/1093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190998 | Quijano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut); GENNAO BIO, INC. (Pennington, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elias Quijano (New Haven, Connecticut); Peter Glazer (New Haven, Connecticut); Bruce Turner (Bryn Mawr, Pennsylvania); Stephen Squinto (New York, New York) |
| ABSTRACT | Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 18/255753 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 47/6807 (20170801) A61K 47/6879 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191189 | Slukvin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor Slukvin (Verona, Wisconsin); Akhilesh Kumar (Middleton, Wisconsin); Saritha Sandra D'Souza (Middleton, Wisconsin) |
| ABSTRACT | The present disclosure provides reagents and methods for producing arterial hemogenic endothelium, hematopoietic progenitor, and lymphoid cell cultures. Pharmaceutical compositions comprising arterial hemogenic endothelium cells, hematopoietic progenitor cells, and lymphoid cells produced by the reagents and methods of the invention and therapeutic methods using these pharmaceutical compositions are also provided. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537479 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) C12N 5/0636 (20130101) Original (OR) Class C12N 2506/45 (20130101) C12N 2510/00 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191208 | Joung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Peter Cabeceiras (Boston, Massachusetts) |
| ABSTRACT | Described herein are minimal virus-like particles (mVLPs), comprising a membrane comprising a phospholipid bilayer with one or more ectodomain-truncated VSV envelope glycoproteins on the external side; and a biomolecule cargo disposed in the core of the mVLP on the inside of the membrane. Preferably, the mVLPs do not comprise a protein from viral gag, pro, pol, or other viral proteins that reside inside of enveloped particles. Also described are methods of use of the mVLPs for delivery of the biomolecule cargo to cells. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511459 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0686 (20130101) C12N 7/00 (20130101) Original (OR) Class C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2760/20222 (20130101) C12N 2760/20223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191212 | Prendergast et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (WYNNEWOOD, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George C. Prendergast (Penn Valley, Pennsylvania); Richard Metz (Pennington, New Jersey) |
| ABSTRACT | The nucleotide and amino acid sequences of indoleamine 2,3-dioxygenase-2 (IDO2) and methods of use thereof are provided. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491078 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Peptides C07K 2319/21 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0069 (20130101) Original (OR) Class C12N 2830/006 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191223 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Omar O. Abudayyeh (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Eric S. Lander (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. |
| FILED | Tuesday, June 13, 2023 |
| APPL NO | 18/334074 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/8213 (20130101) C12N 15/8509 (20130101) C12N 2310/20 (20170501) C12N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191226 | Gittes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | George Gittes (Gibsonia, Pennsylvania); Krishna Prasadan (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods are disclosed herein for treating a subject with type 2 diabetes. These methods include administering to the subject a therapeutically effective amount of an inhibitor that decreases expression of smad2. In some embodiments, the inhibitor is an inhibitory RNA, a small molecule, or a CRISPR-Cas9 system. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/287791 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/16 (20130101) A61K 31/7088 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2750/14143 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191230 | Watts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Watts (Worcester, Massachusetts); Io Long Chan (Worcester, Massachusetts); Feng Wang (Worcester, Massachusetts); Minwook Shin (Boston, Massachusetts) |
| ABSTRACT | This disclosure relates to compounds (“siRNASO”) comprising a double stranded RNA (dsRNA) attached to antisense oligonucleotides (ASO) and heteroduplex oligonucleotides (HDO). Also provided are methods of inhibiting gene expression with the same. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/380871 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/344 (20130101) C12N 2310/3519 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191231 | Singh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravindra N. Singh (Shrewsbury, Massachusetts); Natalia N. Singh (Shrewsbury, Massachusetts); Nirmal K. Singh (Temple, Texas); Elliot J. Androphy (Natick, Massachusetts) |
| ABSTRACT | The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA). |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/487338 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/322 (20130101) C12N 2320/30 (20130101) C12N 2320/33 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2500/04 (20130101) G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191238 | Wyss-Coray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government As Represented By the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton Wyss-Coray (Palo Alto, California); Thomas A. Rando (Stanford, California); Markus Britschgi (Allscwil, Switzerland); Kaspar Rufibach (Basel, Switzerland); Saul A. Villeda (Lancaster, California) |
| ABSTRACT | Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/587147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/7088 (20130101) A61K 38/19 (20130101) A61K 38/45 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/24 (20130101) C07K 16/28 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2799/06 (20130101) C12N 2799/022 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) Enzymes C12Y 207/10001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191256 | Joung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Peter Cabeceiras (Boston, Massachusetts) |
| ABSTRACT | Described herein are programmable tropism virus-like particles (ptVLPs), comprising a membrane comprising a phospholipid bilayer with one or more wild-type or mutant/truncated virus-derived glycoproteins on the external side. The virus-derived envelope glycoprotein(s) can optionally be fused directly to a targeting domain (e.g., peptide, single chain variable fragment (scFv), nanobody, fibronectin type 3 domain (FN3), arginylglycylaspartic acid motif (RGD), single variable domain on a heavy chain/nanobody (VHH), variable domain of new antigen receptor (VNAR), darpin, or other targeting ligand), and/or can be present in combination with a membrane-anchored targeting domain. A biomolecule cargo (preferably fused to a membrane recruitment domain, such as a Pleckstrin homology domain) can be disposed in the core of the ptVLP. Preferably, the ptVLP does not comprise a protein from any human endogenous or exogenous viral gag, pro, pol, or other viral proteins that reside inside of enveloped particles. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511416 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 16/2803 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2760/20222 (20130101) C12N 2760/20223 (20130101) C12N 2760/20252 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191267 | Smolke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Standford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christina D. Smolke (Stanford, California); Prashanth Srinivasan (Stanford, California) |
| ABSTRACT | Provided herein, among other things, is an engineered non-plant cell that produces a tropane alkaloid product, a precursor of a tropane alkaloid product, or a derivative of a tropane alkaloid product by means of a complement of biosynthetic enzymes and a complement of transporter proteins. A method for producing a tropane alkaloid, a precursor of a tropane alkaloid product, or a derivative of a tropane alkaloid product that makes use of the cell is also described. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 18/278735 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/0032 (20130101) C12N 9/0071 (20130101) C12N 9/0073 (20130101) C12N 9/78 (20130101) C12N 9/88 (20130101) C12N 9/93 (20130101) C12N 9/1029 (20130101) C12N 9/1085 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/182 (20130101) Original (OR) Class Enzymes C12Y 101/01001 (20130101) C12Y 101/01206 (20130101) C12Y 101/01237 (20130101) C12Y 105/03011 (20130101) C12Y 114/11011 (20130101) C12Y 114/13101 (20130101) C12Y 114/14001 (20130101) C12Y 203/01035 (20130101) C12Y 205/01016 (20130101) C12Y 205/01022 (20130101) C12Y 305/03001 (20130101) C12Y 305/03011 (20130101) C12Y 401/01017 (20130101) C12Y 401/01019 (20130101) C12Y 403/01023 (20130101) C12Y 403/01024 (20130101) C12Y 602/01012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191279 | CHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hsueh-Chia CHANG (South Bend, Indiana); Pinar ZORLUTUNA (South Bend, Indiana); Satyajyoti SENAPATI (South Bend, Indiana); Xiang REN (South Bend, Indiana) |
| ABSTRACT | Described herein are methods and devices for rapid detection of miRNA and protein biomarkers for diagnosing myocardial infarction and reperfusion injury. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 18/556228 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191284 | Rao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Anjana Rao (La Jolla, California); Mamta Tahiliani (New York, New York); Kian Peng Koh (Jamaica Plain, Massachusetts); Suneet Agarwal (Belmont, Massachusetts); Aravind Iyer (Bethesda, Maryland) |
| ABSTRACT | The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/588956 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1007 (20130101) C12N 2501/70 (20130101) C12N 2501/71 (20130101) C12N 2501/724 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/26 (20130101) C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 2521/531 (20130101) C12Q 2522/10 (20130101) C12Q 2537/164 (20130101) C12Q 2600/154 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191298 | JIANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Ning JIANG (Austin, Texas); Shuqi ZHANG (Austin, Texas); Keyue MA (Austin, Texas); Chenfeng HE (Austin, Texas); Alexandra A. SCHONNESEN (Austin, Texas) |
| ABSTRACT | Provided herein are methods compositions and methods to generate pMHC libraries, and methods of using the pMHC libraries to determine the sequences of T cell receptors, and T cell developmental and activation status. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/534150 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) Original (OR) Class C12Q 2531/113 (20130101) C12Q 2563/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191304 | Testa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph R. Testa (Philadelphia, Pennsylvania); Mitchell Cheung (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides methods of treating a subject having malignant mesothelioma, methods of identifying subjects having an increased risk of developing malignant mesothelioma, methods of detecting human Leucine-Rich Repeat Kinase 2 (LRRK2) variant nucleic acid molecules, and LRRK2 variant nucleic acid molecules. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/287508 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 15/66 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Enzymes C12Y 207/11001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191306 | Markowitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford D. Markowitz (Pepper Pike, Ohio); Helen Moinova (Beachwood, Ohio); Amitabh Chak (University Heights, Ohio); Joseph Willis (Shaker Heights, Ohio); Thomas LaFramboise (Shaker Heights, Ohio) |
| ABSTRACT | The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias. |
| FILED | Thursday, February 01, 2024 |
| APPL NO | 18/430156 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6853 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191943 | Andrews et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| ASSIGNEE(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| INVENTOR(S) | Robert R. Andrews (Norfolk, Massachusetts); Herman E. Snyder (W. Lafayette, Indiana); William J. Merritt (Danvers, Massachusetts); Evan P. Ordway (Salem, Massachusetts); Clair Strohl (Emmaus, Pennsylvania) |
| ABSTRACT | The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port. |
| FILED | Saturday, January 13, 2024 |
| APPL NO | 18/412479 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/16 (20130101) Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 3/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192030 | Kant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Krishan Kant (Cambridge, Massachusetts); David L. Trumper (Plaistow, New Hampshire) |
| ABSTRACT | A position sensor with six degrees of freedom (DoF) measurement capability may be used for position sensing of the rotor in a bearingless slice motor to enable active control. The sensor is designed to fit entirely under the rotor and operates by accessing the rotor bottom surface only, enabling packaging of the pump on the top of the rotor. The sensor has two parts; both operate using eddy currents. One of these parts measures the two radial DoF of the rotor. The other part measures the axial, angular rotation and tip/tilt DoF. The sensor utilizes a conductive target fixed to the underside of the rotor. The design and fabrication of the sensor along with the signal processing methods are described. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/532118 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 7/30 (20130101) Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192194 | Skardal et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aleksander Skardal (Dublin, Ohio); Konstantinos Votanopoulos (Winston-Salem, North Carolina) |
| ABSTRACT | Described herein are devices useful for evaluating tumor cells in vitro, comprising: (a) a device having a chamber, and a channel in fluid communication with the chamber; (b) a live tumor cell construct in the chamber; (c) a growth media in the chamber and the channel; (d) a pump operatively associated with the chamber and channel and configured for circulating the media from the chamber through the channel and back to the chamber; (e) a microporous membrane in the channel and positioned so that the media flows therethrough. Methods of using such devices are also described. |
| FILED | Monday, February 19, 2024 |
| APPL NO | 18/444941 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) C12M 25/16 (20130101) C12M 33/14 (20130101) C12M 35/08 (20130101) C12M 41/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/0679 (20130101) C12N 5/0693 (20130101) C12N 2503/02 (20130101) C12N 2503/04 (20130101) C12N 2513/00 (20130101) C12N 2533/30 (20130101) C12N 2533/80 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192195 | SILVA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ariosto S. SILVA (Tampa, Florida); Praneeth SUDALAGUNTA (Tampa, Florida); Kenneth SHAIN (St. Petersburg, Florida); Rafael Renatino CANEVAROLO (Tampa, Florida); Mark B. MEADS (Tampa, Florida) |
| ABSTRACT | Disclosed are methods for identifying a gene regulatory network and treatment regimens combined with MM standard of care drugs to either delay, or reverse resistance to the standard of care therapy. Also disclosed is a synergy between Selinexor (SELI) and dexamethasone (DEX), pomalidomide (POM), elotuzumab (ELO), and daratumumab (DARA), and expression signatures and mutations associated with response to these agents. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 18/554500 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 20/10 (20180101) G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192223 | Murray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Murray (Rochester, Minnesota); Anand Padmanabhan (Rochester, Minnesota) |
| ABSTRACT | This document relates to methods and materials for assessing and/or treating mammals (e.g., humans) having a monoclonal or oligoclonal gammopathy of thrombotic/thrombocytopenia significance (MGTS). For example, the presence of a population of monoclonal antibodies having binding specificity for a platelet factor 4 (PF4) polypeptide in a sample obtained from a mammal (e.g., a human) can be used to identify the mammal as having MGTS. In some cases, materials and methods for treating a mammal (e.g., a human) identified as having MGTS are provided. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 18/285691 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 2333/522 (20130101) G01N 2800/226 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192226 | Tarca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | Wayne State University (Detroit, Michigan); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Adi L. Tarca (South Lyon, Michigan); Piya Chaemsaithong (Shatin, China Hong Kong); Tinnakorn Chaiworapongsa (Grosse Pointe Park, Michigan); Sonia S. Hassan (Novi, Michigan); Roberto Romero (Grosse Pointe, Michigan) |
| ABSTRACT | Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/414339 |
| CURRENT CPC | Enzymes C12Y 101/01205 (20130101) C12Y 504/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) G01N 33/689 (20130101) Original (OR) Class G01N 2333/4727 (20130101) G01N 2800/368 (20130101) Electric Digital Data Processing G06F 17/18 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192227 | Krolewski |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Joslin Diabetes Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrzej Krolewski (Needham, Massachusetts) |
| ABSTRACT | The present disclosure provides methods for identifying a human subject at risk of developing progressive renal decline by examining a level(s) of a protective protein(s) in a sample from the subject. Level(s) of protein(s) identified in the disclosure are associated with protection against progressive renal failure and end-stage kidney disease (ESKD). Examples of such protective proteins include FGF20, ANGPT1, and TNFSF12. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482419 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/191 (20130101) A61K 38/1825 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/50 (20130101) G01N 2333/525 (20130101) G01N 2333/4709 (20130101) G01N 2333/4722 (20130101) G01N 2800/50 (20130101) G01N 2800/347 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192235 | Kaddurah-Daouk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); METABOLOMICS LABORATORY, BAKER HEART and DIABETE INSTITUTE (Melbourne, Vitoria, Australia); UNIVERSITY OF TEXAS HEALTH CENTER AT SAN ANTONIO (San Antonio, Texas); INDIANA ALZHEIMER DISEASE CENTER AND DEPT. OF RADIOLOGY AND IMAGINING SCIENCES (Indianapolis, Indiana); SUNY DOWNSTATE MEDICAL CENTER (Brooklyn, New York); INTITUTE FOR SYSTEMS BIOLOGY (Seattle, Washington); HELMHOLTZ ZENTRUM MUNCHEN-GERMAN RESEARCH CENTER FOR ENVIRONMENTAL HEALTH (Neuherberg, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rima F. Kaddurah-Daouk (Belmont, Massachusetts); Gregory Louie (Durham, North Carolina); Matthias Arnold (Neuherberg, Germany); Rebecca A. Baillie (Durham, North Carolina); Xianlin Han (San Antonio, Texas); Andrew J. Saykin (Bloomington, Indiana); Kwangsik Nho (Bloomington, Indiana); Herman W. Moreno (Brooklyn, New York); Cory Funk (Seattle, Washington); Priyanka Baloni (Seattle, Washington); Gabriele Kastenmueller (Neuherberg, Germany); Peter Meikle (Melbourne, Australia) |
| ABSTRACT | Described herein are compositions and methods for assessing and modulating ceramide and sphingomyelin in neurological disorders. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 18/554852 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 6/501 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 33/573 (20130101) G01N 2405/08 (20130101) G01N 2800/28 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192707 | Ismagilov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. Ismagilov (Chicago, Illinois); Bo Zheng (Chicago, Illinois); Cory John Gerdts (Chicago, Illinois) |
| ABSTRACT | The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/412395 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 25/314 (20220101) B01F 33/3021 (20220101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/0059 (20130101) B01J 2219/00522 (20130101) B01J 2219/00585 (20130101) B01J 2219/00599 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/0293 (20130101) B01L 3/502746 (20130101) B01L 3/502784 (20130101) B01L 2200/0673 (20130101) B01L 2300/0816 (20130101) B01L 2300/0838 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/38 (20130101) G01N 35/08 (20130101) G01N 2035/1034 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 7/0694 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192776 | Griggs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Whitney S Griggs (Pasadena, California); Sumner L Norman (Pasadena, California); Richard A Andersen (Pasadena, California); Mikhail G Shapiro (Pasadena, California) |
| ABSTRACT | An apparatus and method for a pre-trained brain machine interface based on brain state data is disclosed. An initial session of determining brain state data during performance of a task by a subject at a first time is conducted. The brain state data correlated with task performance are recorded. A pre-training set of the brain state data is assembled. A decoder module of the brain machine interface system is pre-trained via the pre-training set of the recorded brain state data to decode intentions of the subject correlated with brain state. A current session is conducted at a second time subsequent to the first time. The current session includes the decoder module accepting a brain state data input of the brain of the subject, decoding a brain state output from the brain state data input, and generating a control signal to perform the task based on the determined brain state output. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505827 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/015 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/30 (20170101) G06T 2207/10088 (20130101) G06T 2207/30016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193729 | Carrillo-Perez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Francisco Carrillo-Perez (Stanford, California); Marija Pizurica (Stanford, California); Olivier Gevaert (Stanford, California) |
| ABSTRACT | Systems and methods for synthetic image generation include a method of generating synthetic histological slide images that includes translating each of several RNA-Seq records into a latent space, training a first diffusion model to produce a first synthetic histological slide image at a lower resolution using the translated RNA-Seq records and associated histological slides, training a second diffusion model to upscale lower resolution synthetic histological slide images produced by the first diffusion model to higher resolution synthetic histological slide images, obtaining a given RNA-Seq record, translating the given RNA-Seq record into the latent space, providing the latent representation of the given RNA-Seq record to the trained first diffusion model to generate a given lower resolution synthetic histological slide image, and providing the given lower resolution synthetic histological slide image to the trained second diffusion model to generate a given higher resolution synthetic histological slide image. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538743 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4046 (20130101) G06T 3/4053 (20130101) Original (OR) Class G06T 5/50 (20130101) G06T 2207/10056 (20130101) G06T 2207/20016 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 35/20 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193768 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Jason Tyler Smith (Troy, New York); Ruoyang Yao (Elmhurst, New York); Xavier Intes (Schenectady, New York); Pingkun Yan (Clifton Park, New York); Marien Ochoa-Mendoza (Troy, New York) |
| ABSTRACT | One embodiment provides an apparatus for fluorescence lifetime imaging (FLI). The apparatus includes a deep neural network (DNN). The DNN includes a first convolutional layer, a plurality of intermediate layers and an output layer. The first convolutional layer is configured to receive FLI input data. Each intermediate layer is configured to receive a respective intermediate input corresponding to an output of a respective prior layer. Each intermediate layer is further configured to provide a respective intermediate output related to the received respective intermediate input. The output layer is configured to provide estimated FLI output data corresponding to the received FLI input data. The DNN is trained using synthetic data. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/423472 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/045 (20230101) G06N 3/088 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10064 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193772 | ANDERSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander R. A. ANDERSON (Tampa, Florida); Mark ROBERTSON-TESSI (Lutz, Florida); Chandler D. GATENBEE (Tampa, Florida); Sandhya PRABHAKARAN (Tampa, Florida) |
| ABSTRACT | A method of processing medical image data to predict disease progression in non-small cell lung cancer (NSCLC) patients includes receiving a multiplexed tissue image comprising a plurality of cells stained for one or more markers, evaluating the multiplexed tissue image using a machine learning model, and predicting whether a patient's NSCLC will progress based on the evaluation of the multiplexed tissue image using the machine learning model. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 18/556405 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/70 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/136 (20170101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 20/695 (20220101) G06V 20/698 (20220101) G06V 2201/03 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193782 | TRAYANOVA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natalia A. TRAYANOVA (Baltimore, Maryland); Rheeda ALI (Baltimore, Maryland); Julie SHADE (Baltimore, Maryland) |
| ABSTRACT | A device may receive images of a patient, and may perform segmentation of surfaces on the images to create a 3D model. The device may identify normal tissue regions and atrial fibrosis (AF) regions in the 3D model, and may divide the 3D model into the normal tissue regions and the AF regions. The device may assign first cell and tissue properties to the normal tissue regions, and may assign second cell and tissue properties to the AF regions. The device may perform simulations on the normal tissue regions and the AD regions, based on the first and second cell and tissue properties, to generate simulation results, and may extract first features from the simulation results. The device may extract second features from the images, and may process the first and second features, with a model, to select a feature that is predictive of atrial fibrillation recurrence. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/433704 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) Original (OR) Class G06T 2207/10088 (20130101) G06T 2207/20021 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30048 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194290 | CRESCENZI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Orlando CRESCENZI (Apice, Italy); Eugenio NOTOMISTA (Napoli, Italy); César DE LA FUENTA-NUNEZ (Philadelphia, Pennsylvania); Marcelo DER TOROSSIAN TORRES (Philadelphia, Pennsylvania); Marcelo CARDOSO DOS REIS MELO (Philadelphia, Pennsylvania) |
| ABSTRACT | Disclosed are methods for computationally identifying candidate antimicrobial peptides by scanning the human protcome, ranking identified sequences according to a scoring system in order to identify the candidate sequences. Also provided are novel candidate antimicrobial peptides, as well as combinations of peptides that exhibit synergistic antimicrobial properties. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/554531 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/47 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195276 | Kant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Krishan Kant (Cambridge, Massachusetts); David L. Trumper (Plaistow, New Hampshire) |
| ABSTRACT | A bearingless split tooth flux-reversal motor (FRM) for use with a pump, such as a centrifugal blood pump. In some embodiments, the motor has a magnet-free rotor and a magnetic configuration wherein the force generation is independent of the rotor angle, allowing for simple radial force generation using stator-fixed currents. The motor torque can be generated using commutated two-phase currents. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530495 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/109 (20210101) A61M 60/216 (20210101) A61M 60/422 (20210101) Non-positive-displacement Pumps F04D 7/00 (20130101) F04D 13/06 (20130101) Dynamo-electric Machines H02K 1/17 (20130101) H02K 1/246 (20130101) H02K 21/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240188815 | Browne et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vision Products, LLC (Campbell, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. Browne (San Mateo, California); Andrew J. Olson (San Jose, California); Nathan J. Fo (Fremont, California) |
| ABSTRACT | A handheld ophthalmic device configured to perform various optical diagnostic tests to determine the health of a subject's eye. The handheld ophthalmic device is configured to be attached to a smartphone, a cell phone or an electronic tablet. The smartphone, a cell phone or an electronic tablet can be used to view images obtained by the handheld ophthalmic device and to transmit data and images obtained by the handheld ophthalmic device to an ophthalmologist located remotely. |
| FILED | Tuesday, July 18, 2023 |
| APPL NO | 18/354527 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/005 (20130101) Original (OR) Class A61B 3/0008 (20130101) A61B 3/14 (20130101) A61B 3/18 (20130101) A61B 3/0083 (20130101) A61B 3/112 (20130101) A61B 3/117 (20130101) A61B 3/135 (20130101) A61B 3/145 (20130101) A61B 5/0013 (20130101) A61B 5/0077 (20130101) A61B 5/6898 (20130101) A61B 2560/0431 (20130101) A61B 2560/0456 (20130101) A61B 2560/0475 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240188829 | ALLEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NIRSense LLC (Richmond, Virginia) |
| ASSIGNEE(S) | NIRSense LLC (Richmond, Virginia) |
| INVENTOR(S) | Jared Dale ALLEN (Richmond, Virginia); Bretton Robert GOLDBACH (Richmond, Virginia); Areej HABIB (Richmond, Virginia); Jason Michael STROHMAIER (Richmond, Virginia); Ryan Casey BOUTWELL (Richmond, Virginia) |
| ABSTRACT | A near-infrared spectroscopy system for monitoring human physiology in activities related to aircraft comprises a substrate, a light source emitting a set of wavelengths, an optical detector detecting the set of wavelengths, a processor in electronic communication with the light source bank and/or the optical detector, and a memory device in electronic communication with the processor. The light source bank, optical detector, processor, and memory device are mounted on the substrate, and a battery is in electronic communication with at least one of these components. Program instructions direct the processor to calculate an oxygenation level, compare that oxygenation level to a predetermined threshold, and optionally, activate a feedback device. A method of detecting an oxygenation level comprises mounting the system in a wearable article, calculating a baseline oxygenation level, regularly executing the program instructions to calculate the oxygenation level, and activating the feedback device. |
| FILED | Monday, April 04, 2022 |
| APPL NO | 18/553546 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) Original (OR) Class A61B 5/14552 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/359 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189118 | PELZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Joshua PELZ (San Diego, California); Luca DE VIVO (San Diego, California); Falko KUESTER (La Jolla, California); Herbert J. BARRACK (San Diego, California) |
| ABSTRACT | A transtibial prosthetic device comprises a pylon configured as a unitary truss structure formed of a plurality of elongated supports interconnected at nodes and having open spaces between supports of the plurality of elongated supports. The unitary truss structure comprises a polymer. A foot-ankle complex extends from a base of the pylon. The foot-ankle complex comprises an s-shaped posterior portion, an s-shaped anterior portion, and a sole portion. The s-shaped posterior portion and the s-shaped anterior portion both extend from the sole portion, have upper portions with curvatures that are concentric with each other, and are separated from each other by a gap. |
| FILED | Monday, February 19, 2024 |
| APPL NO | 18/581180 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) Original (OR) Class A61F 2/80 (20130101) A61F 2/5046 (20130101) A61F 2/6607 (20130101) A61F 2002/505 (20130101) A61F 2002/607 (20130101) A61F 2002/6621 (20130101) A61F 2002/6642 (20130101) A61F 2002/6685 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189321 | DeBenedetti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Arrigo DeBenedetti (Bossier City, Louisiana); Siddhant Bhoir (Gujarat, India); Vibha Singh (Shreveport, Louisiana); Javeena Hussain (Gujarat, India); Rupesh Chikhale (Manchester, United Kingdom); Richard Bryce (Manchester, United Kingdom); Sivapriya Kirubakaran (Gujarat, India) |
| ABSTRACT | A method of treating prostate cancer in a patient comprising administering to the patient a pharmaceutical composition including a first therapeutic including a TLK1B inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, and a second therapeutic including an antiandrogen or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/509586 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/5415 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189335 | PAINTER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George R. PAINTER (Atlanta, Georgia); Gregory R. BLUEMLING (Decatur, Georgia); Michael G. NATCHUS (Alpharetta, Georgia); David GUTHRIE (Avondale Estates, Georgia) |
| ABSTRACT | This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390347 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7068 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189505 | Rivnay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Israel); WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Rivnay (Chicago, Illinois); Omid Veiseh (Bellaire, Texas); Jacob Robinson (Houston, Texas) |
| ABSTRACT | A bioelectronic wearable device includes engineered cells and an electronically controlled stimulator that regulates a quantity and timing of therapeutic agent produced by the engineered cells. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 18/287684 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) A61M 5/14276 (20130101) Original (OR) Class A61M 2205/3306 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/17 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189549 | Shah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | InnoVital, LLC (Beltsville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Navin Shah (North Potomac, Maryland); Curt Steven Kothera (Rockville, Maryland); Pablo Javier Sztein (Silver Spring, Maryland); Gregory John Hiemenz (Silver Spring, Maryland) |
| ABSTRACT | The present invention is a simple-to-use access device with a safety feature. A catheter advancer (30) is slidably and rotatably integrated with a base (10) to guide advancement of a catheter (50) linearly along the insertion path of a needle (60) and catheter (50). The catheter advancer (30) engages the base (10), catheter (50) and needle (60) and both sequences and delimits relative movement between the base (10), catheter advancer (30), catheter assembly (50) and needle (60). The access device stabilizes and guides the critical needle insertion and catheter advancement steps of a complication-prone and very common procedure. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/388194 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0113 (20130101) A61M 25/0606 (20130101) Original (OR) Class A61M 25/0625 (20130101) A61M 25/0631 (20130101) A61M 2202/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190560 | Speller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Charles Hubert Speller (Flower Mound, Texas); Alan Wayne Falls (Arlington, Texas); Nathan D. Sudek (Fort Worth, Texas) |
| ABSTRACT | A propulsion assembly for a rotorcraft. The propulsion assembly includes a mast having an internal ledge, a raceway station and an external ridge with at least a portion of the raceway station positioned axially between the internal ledge and the external ridge. A nonintegral raceway is receivable by the raceway station to form a press fit joint between the mast and the nonintegral raceway. A mast bearing assembly includes a plurality of bearings configured to engage an outer surface of the nonintegral raceway. The internal ledge is configured to generate a nonuniform normal force between the mast and the nonintegral raceway along the raceway station that axially biases the nonintegral raceway toward the external ridge, thereby securing the nonintegral raceway at the raceway station. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080187 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/14 (20130101) Original (OR) Class Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/10 (20170101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 19/18 (20130101) F16C 2326/43 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190588 | Cristi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roberto Cristi (Pebble Beach, California); Joshua Levitas (Monterey, California); Mark Karpenko (Salinas, California) |
| ABSTRACT | A method, apparatus and system for controlling an attitude of a spacecraft, the spacecraft including an attitude control system operatively associated with a ground-based spacecraft control system. According to an exemplary embodiment, the spacecraft attitude control system uses a B-spline interpolator for commanding the spacecraft and a Kalman filtering process is used to estimate B-spline interpolator coefficients. The methods and systems disclosed herein can be implemented in, for example, executable machine code and/or integrated circuit hardware. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537554 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/245 (20230801) Original (OR) Class B64G 1/2422 (20230801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190789 | Zachariah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); University of Maryland (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael R. Zachariah (Riverside, California); Reza Abbaschian (Riverside, California); Pankaj Ghildiyal (College Park, Maryland); Steven Herrera (Riverside, California) |
| ABSTRACT | Compositions comprising magnesium nanoparticles, a nanoscale metal or metalloid, and an oxidizer and methods of fabrication the compositions are described. One example use of such compositions is in high energy fuel applications. One example method includes fabricating a composite by adding magnesium nanoparticles to a composition of a nanoscale metal or metalloid and an oxidant. Examples of the composition resulting from the described processes provides shorter burn times and a multi-fold increase in reactivity compared to the corresponding composition comprising the same amount of nanoscale metal or metalloid and oxidizer but without the magnesium nanoparticles. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/534467 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0091 (20130101) C06B 33/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190817 | Bellacosa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Institute For Cancer Research D/B/A The Research Institute of Fox Chase Cancer Center (PHILADELPHIA, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfonso Bellacosa (Philadephia, Pennsylvania); John Karanicolas (Philadephia, Pennsylvania); Timothy J. Yen (Philadephia, Pennsylvania); Michael Cory (Philadephia, Pennsylvania); Chris Parry (Philadephia, Pennsylvania); Rahul Prasad (Philadephia, Pennsylvania) |
| ABSTRACT | Phenylsulfonamido compounds that inhibit genome-wide hypomethylation and can be used to treat cancer, including melanoma, prostate cancer, pancreatic cancer, breast cancer, colon cancer, lung cancer, ovarian cancer, and glioblastoma, are provided. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 18/043548 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/4439 (20130101) Acyclic or Carbocyclic Compounds C07C 311/21 (20130101) Original (OR) Class Heterocyclic Compounds C07D 401/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190940 | Robbins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Serice (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Serice (Bethesda, Maryland) |
| INVENTOR(S) | Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland); Gabriel D. Ivey (Washington, District of Columbia); Almin Lalani (North Bethesda, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glutamine at position 61 with lysine. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 18/286911 |
| CURRENT CPC | Peptides C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/10043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191032 | BECKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew BECKER (Chapel Hill, North Carolina); Virginia RITTER (Chappaqua,, New York); Stephen CRAIG (Chapel Hill, North Carolina) |
| ABSTRACT | In various embodiments. the present invention relates to a recyclable, semi-crystalline, mechanochromic elastomeric composition for use in sensor, strain-sensing and shape-memory applications having mechanochromism, SH, and SIC properties that are each strain rate-dependent. In various embodiments, the present invention is directed to a dipropiolate-derivatized spiropyran (SP) mechanophore and thiol-yne-derived stereoelastomers doped with these SP mechanophores. These SP doped, thiol-yne-derived stereoelastomers may be synthesized via a base-directed Michael addition polymerization reaction. These linear polymers have been found to be semi-crystalline, recyclable, and mechanochromic under several methods of mechanical activation. |
| FILED | Friday, May 26, 2023 |
| APPL NO | 18/324739 |
| CURRENT CPC | Heterocyclic Compounds C07D 491/107 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191269 | Terrell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Labortary (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessica L. Terrell (Philadelphia, Pennsylvania); Justin P. Jahnke (Bethesda, Maryland) |
| ABSTRACT | A biofabrication method for producing cellulose-based materials. The method includes providing active cellulose-producing bacteria such as Gluconacetobacter and culturing media in a container; combining organic additives or inorganic additives with the active cellulose-producing bacteria in the container to produce a cellulose hydrogel matrix composed of entangled bacteria-produced cellulose nanofibers; controlling a concentration of the additives in the cellulose hydrogel matrix; and exposing the cellulose hydrogel matrix in selected thermal environment to create a biofabricated functional material. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584254 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 35/33 (20240101) Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Compositions of Macromolecular Compounds C08L 1/02 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191285 | KOELLE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GENECAPTURE, INC. (Huntsville, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paula M. KOELLE (Huntsville, Alabama); Krishnan CHITTUR (Huntsville, Alabama); Valentin KORMAN (Huntsville, Alabama); Zachary McGEE (Huntsville, Alabama) |
| ABSTRACT | Disclosed herein are methods, devices and compositions comprising nucleic acid captor molecules with a stem region and a loop region for detecting target nucleic acids. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/358551 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6837 (20130101) Original (OR) Class C12Q 2525/197 (20130101) C12Q 2525/301 (20130101) C12Q 2565/513 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191368 | DiMascio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Felice DiMascio (Simsburg, Connecticut); Heather D. Willauer (Fairfax Station, Virginia); Jeff Baldwin (Fairfax Station, Virginia); Dennis R. Hardy (California, Maryland) |
| ABSTRACT | The present invention provides a device for carbon dioxide recovery from alkaline water using a module having at least three compartments where each compartment is separated by an electrode pair (anode and cathode) with electrochemical reactions occurring at the electrodes. The electrodes can be in a unipolar or bipolar configuration. Multiple electrochemical modules can be electrically connected in series, in parallel, or in a combination of both series and parallel. Also disclosed it the related process for recovering carbon dioxide from alkaline water. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/536576 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/66 (20130101) C02F 1/46104 (20130101) C02F 2001/46128 (20130101) C02F 2101/10 (20130101) C02F 2103/08 (20130101) C02F 2201/008 (20130101) C02F 2201/4613 (20130101) C02F 2201/4617 (20130101) C02F 2201/46115 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 9/23 (20210101) Original (OR) Class C25B 9/70 (20210101) C25B 11/036 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191653 | Thomas |
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| FUNDED BY |
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| APPLICANT(S) | Achates Power, Inc. (San Diego, California) |
| ASSIGNEE(S) | Achates Power, Inc. (San Diego, California) |
| INVENTOR(S) | Isaac B. Thomas (Carson City, Nevada) |
| ABSTRACT | A piston is configured to be used in a cylinder bore of an opposed-piston. The piston includes a biaxial bearing. The biaxial bearing includes a biaxial wrist pin with a diameter configured to be less than half the diameter of the cylinder bore. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530723 |
| CURRENT CPC | Internal-combustion Piston Engines; Combustion Engines in General F02B 75/282 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191912 | Fackrell et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Joseph Fackrell (Monterey, California); Frank Chase Smeeks, IV (Marina, California); Denntrick Akeem Horton (New Orleans, Louisiana); Steven Wayne Arnold (Monterey, California); Jasmine Tequila Sweet (Monterey, California); Anthony Gerard Pollman (Monterey, California) |
| ABSTRACT | An automated stirling-pelitier liquid air battery includes: a cryocooler to cool a tip of a cold head to cryogenic temperatures, the cryocooler resting in a cryocooler support; the cryocooler support to change a level of the cryocooler in a dewar to maximize liquid air production, the dewar to hold the liquified air at low temperatures, the dewar having the cryocooler support, wherein the dewar further comprises: a polytetrafluoroethylene or glass inner shell that reduces conductive heat loss, and a polytetrafluoroethylene or glass threaded pipe connected to a liquid air transport subsystem; and the liquid air transport subsystem having a thermoelectric generator to generate output electricity from the liquid air received from the dewar. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535896 |
| CURRENT CPC | Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 13/001 (20130101) F17C 2203/0391 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 9/14 (20130101) Original (OR) Class F25B 2309/1428 (20130101) Liquefaction, Solidification or Separation of Gases or Gaseous Mixtures by Pressure and Cold Treatment F25J 2270/91 (20130101) F25J 2270/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191944 | Hlavinka et al. |
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| FUNDED BY |
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| APPLICANT(S) | Terumo BCT, Inc. (Lakewood, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis J. Hlavinka (Arvada, Colorado); Frank Corbin, III (Lakewood, Colorado); Daniel Clement (Lakewood, Colorado) |
| ABSTRACT | A lyophilizer includes a shelf and a container, at least one of the shelf and the container including a material having an emissivity greater than or equal to about 0.6 to less than or equal to about 1.0. A shelf plate includes a plate body and a material layer disposed on or defining one or more surfaces of the plate body, the material layer having an emissivity greater than or equal to about 0.6 to less than or equal to about 1.0. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/526125 |
| CURRENT CPC | Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 5/06 (20130101) Original (OR) Class F26B 25/003 (20130101) F26B 25/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191995 | Sabater |
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| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Andrew B. Sabater (San Diego, California) |
| ABSTRACT | A nonlinear frequency modulated gyroscope includes a degenerate-mode mechanical resonator, positive feedback circuits, a temperature control component, and a gyroscope controller. The degenerate-mode mechanical resonator with two or more modes are coupled via a Coriolis effect. The positive feedback circuits for each mode of the degenerate-mode mechanical resonator include an analog or digital automatic gain control that maintains oscillations of each mode at a constant amplitude. The temperature control component includes a sensor and heating elements. The gyroscope controller is an application-specific integrated circuit, a field programmable gate array, or microcontroller. The degenerate-mode mechanical resonator, the positive feedback circuits, and the temperature control component are subsystems of the nonlinear frequency modulated gyroscope. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063124 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/5776 (20130101) Original (OR) Class G01C 25/005 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/18 (20130101) G01K 7/22 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 23/24 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 1/023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192156 | McClain et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Collin C. McClain (Columbia, Maryland); Michael P. Hunt (Columbia, Maryland) |
| ABSTRACT | A process for selecting an additive and/or solvent for a colloidal ceramic suspension includes measuring spin lattice T1 relaxation times by nuclear magnetic resonance for a ceramic-solvent pair and an additive-solvent pair, wherein the solvent is selected from a plurality of different solvents, and wherein the additive is selected from a plurality of different additives. The process includes determining a relaxation number for each of the ceramic-solvent pairs and the additive-solvent pairs from the spin lattice T1 relaxation times, wherein a higher relaxation number is indicative of strong affinity between the additive and solvent and between the ceramic and solvent. Additionally, the process includes selecting the additive and the solvent based on the relaxation number having the highest relaxation number for the colloidal ceramic suspension. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/477718 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/085 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193097 | Kotra et al. |
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| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | Jagadish B. Kotra (Austin, Texas); John Kalamatianos (Arlington, Massachusetts) |
| ABSTRACT | Address translation is performed to translate a virtual address targeted by a memory request (e.g., a load or memory request for data or an instruction) to a physical address. This translation is performed using an address translation buffer, e.g., a translation lookaside buffer (TLB). One or more actions are taken to reduce data access latencies for memory requests in the event of a TLB miss where the virtual address to physical address translation is not in the TLB. Examples of actions that are performed in various implementations in response to a TLB miss include bypassing level 1 (L1) and level 2 (L2) caches in the memory system, and speculatively sending the memory request to the L2 cache while checking whether the memory request is satisfied by the L1 cache. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/064155 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0897 (20130101) G06F 12/1045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193448 | Akhalwaya et al. |
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| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ismail Yunus Akhalwaya (Emmarentia, South Africa); Kenneth Clarkson (Madison, New Jersey); Lior Horesh (North Salem, New York); Mark Squillante (Greenwich, Connecticut); Shashanka Ubaru (Ossining, New York); Vasileios Kalantzis (White Plains, New York) |
| ABSTRACT | Techniques and a system to facilitate estimation of a quantum phase, and more specifically, to facilitate estimation of an expectation value of a quantum state, by utilizing a hybrid of quantum and classical methods are provided. In one example, a system is provided. The system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can include an encoding component and a learning component. The encoding component can encode an expectation value associated with a quantum state. The learning component can utilize stochastic inference to determine the expectation value based on an uncollapsed eigenvalue pair. |
| FILED | Thursday, March 30, 2023 |
| APPL NO | 18/193082 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/11 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194290 | CRESCENZI et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Orlando CRESCENZI (Apice, Italy); Eugenio NOTOMISTA (Napoli, Italy); César DE LA FUENTA-NUNEZ (Philadelphia, Pennsylvania); Marcelo DER TOROSSIAN TORRES (Philadelphia, Pennsylvania); Marcelo CARDOSO DOS REIS MELO (Philadelphia, Pennsylvania) |
| ABSTRACT | Disclosed are methods for computationally identifying candidate antimicrobial peptides by scanning the human protcome, ranking identified sequences according to a scoring system in order to identify the candidate sequences. Also provided are novel candidate antimicrobial peptides, as well as combinations of peptides that exhibit synergistic antimicrobial properties. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/554531 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/47 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194823 | Torres, JR. et al. |
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| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Carlos M. Torres, JR. (San Diego, California); James R. Adleman (San Diego, California); Sanja Zlatanovic (San Diego, California) |
| ABSTRACT | A two-dimensional quantum light emitting device includes a substrate, two or more monolayers, one or more positive electrodes, and one or more negative electrodes. The substrate grows two or more monolayers on a surface of the substrate. The two or more monolayers have a tunable bandgap ranging from about 477 nm to about 620 nm and have a tunable twist angle. The one or more positive electrodes and the one or more negative electrodes provide a current to an active region of the two or more monolayers and are interdigitated electrodes, non-interdigitated electrodes, piezoelectric electrodes, or a combination thereof that tune the twist angle of the two or more monolayers in-situ. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/063751 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) Original (OR) Class H01L 33/42 (20130101) H01L 33/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194940 | Yersak et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the Univerity of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. Yersak (San Diego, California); Se-Hee LEE (Louisville, Colorado); Conrad STOLDT (Golden, Colorado) |
| ABSTRACT | An all-solid-state lithium battery, thermo-electromechanical activation of Li2S in sulfide based solid state electrolyte with transition metal sulfides, and electromechanical evolution of a bulk-type all-solid-state iron sulfur cathode, are disclosed. An example all-solid-state lithium battery includes a cathode having a transition metal sulfide mixed with elemental sulfur to increase electrical conductivity. In one example method of in-situ electromechanically synthesis of Pyrite (FeS2) from Sulfide (FeS) and elemental sulfur (S) precursors for operation of a solid-state lithium battery, FeS+S composite electrodes are cycled at moderately elevated temperatures. |
| FILED | Wednesday, November 22, 2023 |
| APPL NO | 18/517882 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) H01M 4/382 (20130101) H01M 4/386 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194955 | Laicer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Castro Laicer (Action, Massachusetts); Pavithra Murugavel Shanthi (Natick, Massachusetts); Katherine Harrison (Arlington, Massachusetts) |
| ABSTRACT | An electrolyte includes a lithium (Li) salt, a fluorinated solvent, a 1,3-dioxaolane (DOL) solvent, a 1,2-dimethyoxyethane (DME) solvent, a lithium polysulfide (LiPS), and a lithium nitrate (LiNO3). Lithium sulfur electrochemical devices, such as lithium electrochemical cells and lithium-sulfur batteries, such as lithium-sulfur rechargeable (secondary) batteries include an electrolyte that includes a lithium (Li) salt, a fluorinated solvent, a 1,3-dioxaolane (DOL) solvent, a 1,2-dimethyoxyethane (DME) solvent, a lithium polysulfide (LiPS), and a lithium nitrate (LiNO3). |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/286863 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0565 (20130101) H01M 10/0567 (20130101) H01M 10/0569 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 2300/0037 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195068 | Camp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | James Thomas Camp (Colonial Beach, Virginia); Douglas Mark Wilson (King George, Virginia); Joseph Adam Gibson (Montross, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | James Thomas Camp (Colonial Beach, Virginia); Douglas Mark Wilson (King George, Virginia); Joseph Adam Gibson (Montross, Virginia) |
| ABSTRACT | A capacitively or inductively driven spiral antenna creates an electric current distribution of a dipole, which generates a sensible magnetic field for various military applications including detecting and pre-detonating improvised explosive devices (IEDs). The antenna includes a dielectric substrate, a spiral antenna, driving elements such as tuning forks or loop, and a coaxial cable that connects to a source terminal. The substrate is a low dielectric loss insulating material to provide support for the antenna. The spiral antenna is tuned to a natural frequency is disposed on the substrate. The coaxial cable extends from the substrate to the source terminal. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/079559 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/36 (20130101) H01Q 7/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195140 | Soljacic et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marin Soljacic (Belmont, Massachusetts); Nicholas Rivera (Somerville, Massachusetts); Jamison Sloan (Somerville, Massachusetts); Yannick Salamin (Arlington, Massachusetts) |
| ABSTRACT | A principle which enables the generation of macroscopic Fock and sub-Poissonian states is disclosed. Generic components of the system include: an electromagnetic structure (possessing one or more electromagnetic resonances), a nonlinear electromagnetic element (such as a nonlinear crystal near or inside the structure), and a source of light. In one embodiment, stimulated gain is used to create large numbers of photons in a cavity, but with very low photon number noise (uncertainty) in the cavity, and thus acts as a Fock laser. This Fock laser is capable of producing these states due to a very sharp intensity-dependent gain (or loss) that selects a particular photon number. The disclosed system and method are robust against both atomic and optical decoherence. Various examples of the new Fock laser design are also described. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 18/286790 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/354 (20210101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/109 (20130101) Original (OR) Class H01S 3/1611 (20130101) H01S 3/1643 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195299 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ryan S. Johnson (Santa Cruz, California); Berk Altin (Santa Cruz, California); Ricardo G. Sanfelice (Santa Cruz, California) |
| ABSTRACT | A hybrid active controller for practically asymptotically stabilizing the DC-DC boost converter under parameter uncertainty. The controller uses an estimation algorithm that identifies the input voltage and output load of the converter in finite time. Using these estimates, the control algorithm “unites” global and local control schemes. The global control scheme induces practical asymptotic stability of a desired output voltage and corresponding current, and the local control scheme maintains industry-standard PWM behavior during steady state. Stability properties for the resulting hybrid closed-loop system are established and simulation results illustrating the main results are provided. |
| FILED | Thursday, June 22, 2023 |
| APPL NO | 18/339712 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/158 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195361 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Shuo-Wei CHEN (Los Angeles, California); Aoyang ZHANG (Los Angeles, California) |
| ABSTRACT | A subharmonic switching power amplifier architecture includes a power amplifier core that includes at least one power amplifier that receives an input signal and is operable in a power back-off region. Characteristically, the at least one power amplifier is configured to be toggled at a carrier frequency (Fc) when the power level of the input signal is equal to or higher than a predetermined power level and at a subharmonic component of the carrier frequency when the power level of the input signal is less than the predetermined power level. Concurrent harmonic tuning and subharmonic tuning is implemented to enhance the efficiency at both peak power mode and power back-off mode. Characteristically, the power amplifier being configured to be operated by a voltage mode or current mode driver and in the current mode with zero-voltage-switching. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 18/288021 |
| CURRENT CPC | Amplifiers H03F 1/0244 (20130101) Original (OR) Class H03F 1/565 (20130101) H03F 3/2176 (20130101) H03F 2200/451 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195626 | Hale et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Britta Hale (Monterey, California); Douglas Lee Van Bossuyt (Monterey, California) |
| ABSTRACT | A method and system including, using an authenticated encryption with associated data (AEAD) process, encrypting and authenticating a non-fungible token (NFT) and authenticating a NFT descriptor without encryption to generate a limited access non fungible tokens (LANFT), the LANFT including an authenticated and encrypted NFT portion and an authenticated and nonencrypted NFT descriptor portion which is viewable by a user prior to obtaining ownership of the NFT; and in response to receiving a confirmation that the user has obtained ownership of the NFT, providing a private key to the user, wherein the private key is used to decrypt the NFT. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537426 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101) H04L 9/3213 (20130101) Original (OR) Class H04L 9/3218 (20130101) H04L 2209/603 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195726 | Fouad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hesham Fouad (Arlington, Virginia); Stephen Russell (Laurel, Maryland); Antonio Gilliam (Hopewell, Virginia) |
| ABSTRACT | Systems and methods are provided for addressing the complexity inherent in evaluating Service Oriented Architecture (SOA) systems by using meta-agent based adaptation in multi-agent systems. Embodiments of the present disclosure provide a multi-agent based automated evaluation capability for distributed, SOA systems that can dynamically adapt to the non-deterministic nature of such systems to enable a continuous monitoring capability for detecting and circumventing operational errors as they arise. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/382036 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/046 (20130101) H04L 43/10 (20130101) H04L 43/50 (20130101) Original (OR) Class H04L 67/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240196718 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuze Lin (Chapel Hill, North Carolina); Ye Liu (Chapel Hill, North Carolina); Shangshang Chen (Chapel Hill, North Carolina); Jinsong Huang (Chapel Hill, North Carolina) |
| ABSTRACT | Described herein are surface treatment methods for removing one or more surface defect layers from polycrystalline films, polycrystalline films that are free of one or more defect surface layers, and use of the films in solar cells. In certain embodiments, the method is conducted by means of an adhesive tape or mechanical polishing. As described herein, solar cells containing the surface treated perovskite films show enhanced efficiency and stability. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 18/245387 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/24 (20130101) C07F 19/00 (20130101) Organic electric solid-state devices H10K 30/40 (20230201) H10K 30/50 (20230201) H10K 71/20 (20230201) Original (OR) Class H10K 85/50 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240188927 | Yarmush et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin L. Yarmush (Newton, Massachusetts); Alvin Chen (Cambridge, Massachusetts); Max Balter (Boston, Massachusetts); Joshua Leipheimer (Highland Park, New Jersey) |
| ABSTRACT | A device and method for directing a cannula toward a target location under a patient's skin. The device is handheld and the device operations may be automated. The device includes an imaging probe for imaging the target location, a positioning unit for manipulating a cannula towards the target location, and a processor. The processor receives imaging data from the imaging probe, cannula pose data from at least one cannula position sensor, and device pose data from at least one device position sensor. The target location is identified from the imaging data, and a trajectory for manipulating the cannula towards the target location is determined based on the imaging data, the cannula pose data, and the device pose data. The processor may determine that the trajectory becomes misaligned with the target position, and may update to a corrected trajectory based on the imaging data, cannula pose data, and device pose data. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/586675 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/12 (20130101) A61B 8/466 (20130101) A61B 8/0841 (20130101) Original (OR) Class A61B 8/4218 (20130101) A61B 2034/2065 (20160201) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189118 | PELZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Joshua PELZ (San Diego, California); Luca DE VIVO (San Diego, California); Falko KUESTER (La Jolla, California); Herbert J. BARRACK (San Diego, California) |
| ABSTRACT | A transtibial prosthetic device comprises a pylon configured as a unitary truss structure formed of a plurality of elongated supports interconnected at nodes and having open spaces between supports of the plurality of elongated supports. The unitary truss structure comprises a polymer. A foot-ankle complex extends from a base of the pylon. The foot-ankle complex comprises an s-shaped posterior portion, an s-shaped anterior portion, and a sole portion. The s-shaped posterior portion and the s-shaped anterior portion both extend from the sole portion, have upper portions with curvatures that are concentric with each other, and are separated from each other by a gap. |
| FILED | Monday, February 19, 2024 |
| APPL NO | 18/581180 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) Original (OR) Class A61F 2/80 (20130101) A61F 2/5046 (20130101) A61F 2/6607 (20130101) A61F 2002/505 (20130101) A61F 2002/607 (20130101) A61F 2002/6621 (20130101) A61F 2002/6642 (20130101) A61F 2002/6685 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189458 | TABOR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William Marsh Rice University (Houston, Texas); Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas); Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Jeffrey TABOR (Houston, Texas); Omid VEISEH (Houston, Texas); Robert BRITTON (Houston, Texas); Moshe BARUCH (Houston, Texas); Annie GOODWIN (Houston, Texas); Elena MUSTEATA (Houston, Texas); Michael DOERFERT (Houston, Texas); Samira AGHLARA-FOTOVAT (Houston, Texas); Maxwell HUNT (Houston, Texas) |
| ABSTRACT | The present disclosure provides compositions comprising encapsulated engineered bacteria. The bacteria may be engineered to act as sensors of biomarkers, such as inflammation, as well as to produce diagnostic or therapeutic agents. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 18/570949 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/4808 (20130101) A61K 9/5015 (20130101) A61K 9/5036 (20130101) A61K 9/5094 (20130101) A61K 9/5115 (20130101) A61K 35/74 (20130101) A61K 49/0008 (20130101) Original (OR) Class A61K 49/0091 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) C12N 11/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189490 | GOTTARDI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (, None) |
| INVENTOR(S) | Riccardo L. GOTTARDI (Philadelphia, Pennsylvania); Matthew R. ARONSON (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides improved airway intervention devices that are coated with a material and contain an antimicrobial peptide. The devices are useful in controlling the microbial flora of the airway and preventing infections and conditions such as subglottic stenosis, pneumonia (VAP), laryngeal infection, post-operative dressing/packing-induced infection, upper airway infection, rhinosinusitis, choanal atresia, vocal fold injury and paralysis. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/553893 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) A61L 31/16 (20130101) Original (OR) Class A61L 31/048 (20130101) A61L 2300/252 (20130101) A61L 2300/404 (20130101) A61L 2420/02 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0402 (20140204) A61M 2205/0205 (20130101) A61M 2205/0238 (20130101) A61M 2207/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189820 | Robles Guerrero et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cellia Science, Inc. (Fayetteville, Arkansas); Gener8 LLC (San Jose, California); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francisco E. Robles Guerrero (Atlanta, Georgia); Jiyang Mei (San Diego, California); Kelly Marie Pollock Mabry (Redwood City, California) |
| ABSTRACT | The present invention is directed to systems, methods, and apparatus for an improved microfluidic cell imaging system that allows for the simultaneous application of a compression force to a biological specimen forming a consistent cell monolayer while imaging the cells. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/533935 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/025 (20130101) B01L 2200/0663 (20130101) B01L 2300/0654 (20130101) B01L 2300/0816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189980 | Fey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Fey (Jonestown, Texas); Ross Neuman (Austin, Texas) |
| ABSTRACT | Aspects of the present invention relate to methods for informing the design of exosuits using modeling and optimization methods, and a soft exosuit device including a belt having a plurality of loops attached thereto, and a plurality of attachment regions between each loop on the belt, configured to be positioned around a subject, one or more brackets slidably attached to the belt and positionable within the one or more attachment regions, each bracket having one or more belt attachment points, at least one brace having one or more brace attachment points configured to be positioned around a body part of the subject, at least one element having a first fastener at a proximal end removably attached to a belt attachment point and a second fastener at a distal end, removably attached to a brace attachment point. |
| FILED | Wednesday, July 26, 2023 |
| APPL NO | 18/359521 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) Original (OR) Class B25J 9/1045 (20130101) B25J 9/1694 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190799 | Knowles et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey); CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert R. Knowles (Princeton, New Jersey); Suong T. Nguyen (Princeton, New Jersey); Elizabeth A. Mcloughlin (Plainsboro, New Jersey); James H. Cox (Princeton, New Jersey); Brett P. Fors (Ithaca, New York) |
| ABSTRACT | In one aspect, methods of depolymerization are described herein comprising providing a synthetic polymer including a hydroxylated aliphatic backbone or hydroxylated backbone segments, and homolytically activing O—H bonds of the hydroxyl groups. Homolytic activation induces the formation of alkoxy radical intermediates followed by C—C bond β-scission events breaking the polymer backbone into depolymerization products. In some embodiments, depolymerization products comprise alkyl radical intermediates reduced by hydrogen atom transfer. Moreover, in some embodiments, the depolymerization products are further reacted into difunctionalized products or comprise functionalities derived from the polymer structure. The difunctionalized products can subsequently be employed in polymerization processes for the production of additional synthetic polymers. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 18/285087 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 1/22 (20130101) C07C 29/00 (20130101) C07C 37/055 (20130101) C07C 41/18 (20130101) Original (OR) Class C07C 45/55 (20130101) C07C 51/00 (20130101) C07C 253/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/16 (20130101) C08G 69/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190804 | Davies et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huw M. L. Davies (Suwanee, Georgia); Joshua Sailer (Lewisville, North Carolina); Jack C. Sharland (Mendham, New Jersey); Bo Wei (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to compositions comprising diruthenium catalysts and uses related thereto. In certain embodiments, the diruthenium catalyst comprises a cyclopropyl ring substituted with a carboxylic acid ligand. In certain embodiments, the diruthenium catalyst comprises an N-(sulfonyl)pyrrolidine ring substituted with a carboxylic acid ligand. In certain embodiments, the diruthenium catalyst comprises a 2-(1,3-dioxoisoindolin-2-yl)acetic acid ligand. In certain embodiments, this disclosure relates to methods of using catalysts in chemical transformations disclosed herein. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 18/276736 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/223 (20130101) B01J 2231/4283 (20130101) B01J 2531/0219 (20130101) B01J 2531/821 (20130101) Acyclic or Carbocyclic Compounds C07C 67/343 (20130101) Original (OR) Class C07C 2531/22 (20130101) C07C 2601/02 (20170501) C07C 2601/14 (20170501) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191004 | Pan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Liang Pan (West Lafayette, Indiana); Xianfan Xu (West Lafayette, Indiana); Bryan William Boudouris (West Lafayette, Indiana) |
| ABSTRACT | A three-dimensional nanolithography system includes forming a photocurable resin including one or more organic monomers, a photoinitiator, and an inhibitor, defining a lithographical patterning region, directing a light beam toward the lithographical patterning region to initiate polymerization, and controlling an initiator depletion technique to reduce an undesired portion of the polymerization. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/539218 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/20 (20170801) B29C 64/135 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0005 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/50 (20130101) Original (OR) Class C08F 222/102 (20200201) C08F 222/103 (20200201) C08F 222/105 (20200201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191181 | ALBERT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin J. ALBERT (Ithaca, New York); Jonathan BUTCHER (Ithaca, New York) |
| ABSTRACT | The present disclosure relates to a method of fabricating an article. This method involves obtaining a non-planar surface model of an article to be fabricated; creating X and Y coordinates of the surface to create an X-Y plane; creating planes orthogonal to the X-Y plane to obtain lines of intersection between the surface and said planes; correlating coordinates of intersecting lines to create non-planar print paths; and printing along the print paths to fabricate the article. Also disclosed are a system and a computer program product that functions to control a system to carry out the methods of the present disclosure. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/554578 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/336 (20170801) B29C 64/386 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2005/00 (20130101) B29K 2105/0061 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7532 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/00 (20141201) B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2533/54 (20130101) C12N 2533/74 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191327 | KANER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Richard B. KANER (Pacific Palisades, California); Sarah H. TOBERT (Encino, California); Reza MOHAMMADI (Los Angeles, California); Andrew T. LECH (Los Angeles, California); Miao XIE (Los Angeles, California) |
| ABSTRACT | A composition includes tungsten (W); at least one element selected form the group of elements consisting of boron (B), beryllium (Be) and silicon (Si); and at least one element selected from the group of elements consisting of titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), zirconium (Zr), niobium (Nb), molybdenum (Mo), ruthenium (Ru), hafnium (fi), tantalum (Ta), rhenium (Re), osmium (Os), iridium (Ir), lithium (Li) and aluminum (Al). The composition satisfies the formula W1-xMxXy wherein X is one of B, Be and Si; M is at least one of Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Zr, Nb, Mo, Ru, Hf, Ta, Re, Os, Ir, Li and Al; x is at least 0.001 and less than 0.999; and y is at least 4.0. A tool is made from or coated with this composition. |
| FILED | Thursday, November 30, 2023 |
| APPL NO | 18/525418 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/04 (20130101) B22F 2005/001 (20130101) B22F 2009/041 (20130101) Alloys C22C 1/02 (20130101) C22C 1/045 (20130101) C22C 1/1084 (20130101) C22C 27/04 (20130101) Original (OR) Class C22C 29/14 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 30/00 (20130101) C23C 30/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191365 | Jin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Song Jin (Madison, Wisconsin); Jordan Schmidt (Fitchburg, Wisconsin); Hongyuan Sheng (Los Angeles, California); Kwanpyung Lee (Madison, Wisconsin); Richard Ross (Madison, Wisconsin); Aurora Janes (Philadelphia, Pennsylvania) |
| ABSTRACT | Disclosed herein is an electrochemical cell comprising an electrolyte and a cathode immersed in the electrolyte, wherein the cathode comprises a two-electron oxygen reduction reaction (2e− ORR) electrocatalyst composed of a metal chalcogenide. Also disclosed are methods for production of hydrogen peroxide or preparing oxidation products of a biomass-derived feedstock with the electrochemical cells described herein. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/532418 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/30 (20130101) Original (OR) Class C25B 11/053 (20210101) C25B 11/081 (20210101) C25B 15/087 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192162 | Das et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundatno (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suprem R. Das (Manhattan, Kansas); Rajavel Krishnamoorthy (Manhattan, Kansas); Thiba Nagaraja (Manhattan, Kansas) |
| ABSTRACT | Graphene-based electrochemical sensors and uses thereof in detecting and measuring the concentration of a target substance with a sample are provided. In particular, the sensors, comprising electrodes printed from a graphene ink, can be configured to monitor phosphate ion concentration in the environment, including within soil and/or surface water. |
| FILED | Thursday, December 28, 2023 |
| APPL NO | 18/399402 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/49 (20130101) G01N 27/301 (20130101) G01N 27/308 (20130101) G01N 27/413 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192528 | Marino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emanuele Marino (Palermo, Italy); Steven J. Neuhaus (San Jose, California); Christopher B. Murray (Bala Cynwyd, Pennsylvania); Cherie R. Kagan (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | A method for stabilizing a quantum dot's emission spectrum, comprising: illuminating the quantum dot with an illumination fluence sufficient to effect a persistent reduction in blue-shift over time in the quantum dot's spectrum. A method, comprising discriminating between a first quantum dot and a second quantum dot on the basis of spectral stabilities of the first quantum dot and the second quantum dot. A method, comprising: illuminating a quantum dot with a first fluence so as to effect a first emission color from the quantum dot; and illuminating the quantum dot with a second fluence so as to effect a second emission color from the quantum dot, the first fluence and the second fluence differing in intensity. A spectrally-stabilized quantum dot, the spectrally-stabilized quantum dot exhibiting a spectral shift of less than about 2.5 meV over about 15 minutes of continuous operation. |
| FILED | Thursday, January 04, 2024 |
| APPL NO | 18/404733 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0158 (20210101) G02F 1/01791 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192707 | Ismagilov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. Ismagilov (Chicago, Illinois); Bo Zheng (Chicago, Illinois); Cory John Gerdts (Chicago, Illinois) |
| ABSTRACT | The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/412395 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 25/314 (20220101) B01F 33/3021 (20220101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/0059 (20130101) B01J 2219/00522 (20130101) B01J 2219/00585 (20130101) B01J 2219/00599 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/0293 (20130101) B01L 3/502746 (20130101) B01L 3/502784 (20130101) B01L 2200/0673 (20130101) B01L 2300/0816 (20130101) B01L 2300/0838 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/38 (20130101) G01N 35/08 (20130101) G01N 2035/1034 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 7/0694 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192837 | Chiou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Chiou (Los Angeles, California); Ali Alotaibi (Los Angeles, California); William Halfond (Los Angeles, California) |
| ABSTRACT | A method for detecting and/or localizing keyboard accessibility failures (KAFs) in a web page is disclosed. A document object model of a web page is read. A keyboard navigation flow model is generated from the document object model of the web page based on interactions of a user with the web page. The model includes states representing user interfaces displayed by the web page, nodes representing keyboard inputs in the states, and edges representing transitions that occur in the web page between the nodes. KAFs are detected based on an analysis of the keyboard navigation flow model. A report of the detected one or more KAFs on the web page is produced. The KAFs include unintuitive navigation failures, reflow related failures, and dialog related failures. |
| FILED | Monday, January 29, 2024 |
| APPL NO | 18/425743 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/023 (20130101) G06F 3/0484 (20130101) Original (OR) Class G06F 16/9577 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193452 | LESTER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Atom Computing Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian LESTER (Berkeley, California); Benjamin BLOOM (Boulder, Colorado); Krish KOTRU (Berkeley, California); Jonathan KING (Berkeley, California); Mickey MCDONALD (Boulder, Colorado); Mark STONE (Berkeley, California) |
| ABSTRACT | In an aspect, the present disclosure provides a method comprising providing a plurality of atoms. At least one atom of the plurality of atoms may have a different state than one or more other atoms of the plurality of atoms. The at least one atom may be excited to an excited state. The exciting may be performed using a non-site selective excitation beam over the plurality of atoms that only interacts with the at least one atom. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508585 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194237 | Barve et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Universty of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siddharth Barve (Mason, Ohio); Rashmi Jha (Wyoming, Ohio) |
| ABSTRACT | An apparatus may comprise a synapse comprising a first reconfigurable field-effect transistor; a second reconfigurable field-effect transistor connected in parallel to the first reconfigurable field-effect transistor; an input voltage applied to each of the first reconfigurable field-effect transistor and the second reconfigurable field-effect transistor corresponding to an input attribute associated with an error computation; and a current sensor measures a saturation drain current of the first reconfigurable field-effect transistor and the second reconfigurable field-effect transistor and determines a Euclidean error based on the saturation drain current of the FETs |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/534269 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/063 (20130101) Static Stores G11C 11/54 (20130101) G11C 11/223 (20130101) Original (OR) Class G11C 11/2275 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/78391 (20140902) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194305 | Ong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shyue Ping Ong (San Diego, California); Jian Luo (San Diego, California); Yunxing Zuo (San Diego, California); Mingde Qin (San Diego, California); Chi Chen (San Diego, California) |
| ABSTRACT | A method for machine learning enabled material design may include applying a first machine learning model trained to generate an equilibrium crystal structure corresponding a crystal structure generated, for example, by performing an elemental substation. The first machine learning model may generate the equilibrium crystal structure by iteratively searching a solution space including possible variations of the crystal structure for a variation having a minimum formation energy. The searching may be constrained to variations having a same symmetry as the crystal structure. Properties of the crystal structure may be determined, for example, by applying a second machine learning to the equilibrium crystal structure. The crystal structure may be identified as a candidate for synthesis based the properties of the crystal structure, such as an above-threshold elastic modulus corresponding to an ultra-incompressibility. Various materials identified using this method and related systems and computer program products are also provided. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/555664 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/70 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194802 | YU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward T. YU (Austin, Texas); Soonil LEE (Austin, Texas); Li JI (Austin, Texas) |
| ABSTRACT | Disclosed herein are photoelectrodes and methods of making and use thereof. For example, disclosed herein are photo-electrodes comprising: a light absorbing layer; an insulator layer disposed on the light absorbing layer, wherein the insulator layer has an average thickness of 20 nanometers (nm) or more; and a set of protrusions, wherein each protrusion penetrates through the insulator layer to the light absorbing layer, such that each protrusion is in physical and electrical contact with the light absorbing layer; and a plurality of particles disposed on the insulator layer, wherein a least a portion of the plurality of particles are in physical and electrical contact with at least a portion of the set of protrusions; and wherein the plurality of particles and optionally the set of protrusions comprise a catalyst material. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 18/286175 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1864 (20130101) H01L 31/022408 (20130101) Original (OR) Class Organic electric solid-state devices H10K 30/40 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194808 | Bradley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PixelEXX Systems, Inc. (Hinsdale, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Forbes Bradley (Hinsdale, Illinois); Marco Nardone (Bowling Green, Illinois); Renee Kathryn Carder (Hinsdale, Illinois) |
| ABSTRACT | A Mie photo sensor is described. A Mie photo sensor is configured to leverage Mie scattering to implement a photo sensor having a resonance. The resonance is based on various physical and material properties of the Mie photo sensor. In an example, a Mie photo sensor includes a layer of semiconductor material with one or more mesas. Each mesa of semiconductor material may include a scattering center. The scattering center is formed by the semiconductor material of the mesa being at least partially surround by a material with a different refractive index than the semiconductor material. The abutting refractive index materials create an interface that forms a scattering center and localizes the generation of free carriers during Mie resonance. One or more electrical contacts may be made to the mesa to measure the electrical properties of the mesa. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/502834 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/02327 (20130101) H01L 31/035281 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194854 | BAI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng BAI (St. Louis, Missouri); Bingyuan MA (St. Louis, Missouri); Youngju LEE (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to a rechargeable anode-free sodium metal battery including: a cathode substrate; a cathode nanomaterial deposited onto the cathode substrate; a nonaqueous electrolyte, wherein a total water content of the non-aqueous electrolyte is about 10 ppm or less; and an anode substrate, wherein the anode substrate has no deposited material prior to battery recharge, and wherein the anode substrate comprises an ingot-type, non-porous sodium metal surface formed during battery recharge. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 18/552936 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/136 (20130101) Original (OR) Class H01M 4/0438 (20130101) H01M 10/054 (20130101) H01M 10/058 (20130101) H01M 10/0568 (20130101) H01M 50/411 (20210101) H01M 50/457 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194895 | SONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WEST VIRGINIA UNIVERSITY BOARD OF GOVERNORS ON BEHALF OF WEST VIRGINIA UNIVERSITY (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xueyan SONG (Pittsburgh, Pennsylvania); Yun CHEN (Pittsburgh, Pennsylvania) |
| ABSTRACT | In one aspect, the disclosure relates to ALD-coated cells comprising a conformal ultra-thin nanocomposite comprising Pt and CoOx on a LSCF/SDC cathode backbone. In a further aspect, the ALD-coated cells comprising an ultra-thin nanocomposite comprising Pt and CoOx on a LSCF/SDC cathode backbone are prepared using a disclosed Atomic Layer Deposition (ALD) coating method. In a still further aspect, the disclosed ALD-coated cells comprise a heterogeneous coating layer comprising subjacent discrete Pt nanoparticles capped with superjacent fully dense conformal CoOx layer. In a yet further aspect, the performance of the disclosed ALD-coated cells is improved compared to baseline cells lacking the disclosed ALD coating on a LSCF/SDC cathod backbone. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 18/287636 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/925 (20130101) H01M 4/8657 (20130101) Original (OR) Class H01M 4/8867 (20130101) H01M 4/9033 (20130101) H01M 2004/8689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194918 | Van Nguyen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trung Van Nguyen (Lawrence, Kansas); Yuanchao Li (Lawrence, Kansas) |
| ABSTRACT | Provided are forward osmosis processes to increase the concentration of a dilute metal salt solution, e.g., a vanadium electrolyte solution. In embodiments, such a process comprises: (a) delivering a draw solution to a draw chamber of a forward osmosis module, the draw solution comprising water and sulfuric acid at a draw acid concentration, wherein the draw solution is free of vanadium cations; and (b) delivering a feed solution to a feed chamber of the forward osmosis module, the draw and feed chambers separated by a membrane, the feed solution comprising water, vanadium cations, and sulfuric acid at a feed acid concentration that is lower than the draw acid concentration, wherein water passes across the membrane from the feed solution to the draw solution, thereby providing a concentrated vanadium electrolyte solution as a feed chamber output and a diluted acid solution as a draw chamber output. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537021 |
| CURRENT CPC | Separation B01D 61/005 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 31/00 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/08 (20130101) Original (OR) Class H01M 8/188 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195299 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ryan S. Johnson (Santa Cruz, California); Berk Altin (Santa Cruz, California); Ricardo G. Sanfelice (Santa Cruz, California) |
| ABSTRACT | A hybrid active controller for practically asymptotically stabilizing the DC-DC boost converter under parameter uncertainty. The controller uses an estimation algorithm that identifies the input voltage and output load of the converter in finite time. Using these estimates, the control algorithm “unites” global and local control schemes. The global control scheme induces practical asymptotic stability of a desired output voltage and corresponding current, and the local control scheme maintains industry-standard PWM behavior during steady state. Stability properties for the resulting hybrid closed-loop system are established and simulation results illustrating the main results are provided. |
| FILED | Thursday, June 22, 2023 |
| APPL NO | 18/339712 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/158 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240190706 | Hoff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl Hoff (Miami, Florida); Oswaldo Guio (Miami, Florida) |
| ABSTRACT | Provided herein is a process for preparing a nitrate comprising contacting a nitrogen oxide with a metal oxide under milling conditions to form a nitrate. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/286788 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 21/48 (20130101) Original (OR) Class C01B 21/50 (20130101) Nitrogenous Fertilisers C05C 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190768 | Srubar, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Wilfred V. Srubar, III (Boulder, Colorado); Xu Chen (Lafayette, Colorado) |
| ABSTRACT | Cement mixtures comprising a hydration retarder comprising algae, cement additives comprising algae and/or derivatives thereof, and methods of forming and using the mixtures and additives are disclosed. The algae can be treated to form desired functional groups to tune retardation properties of the hydration retarder. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 18/285246 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 18/24 (20130101) Original (OR) Class C04B 20/023 (20130101) C04B 28/04 (20130101) C04B 2103/0001 (20130101) C04B 2103/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190799 | Knowles et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey); CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert R. Knowles (Princeton, New Jersey); Suong T. Nguyen (Princeton, New Jersey); Elizabeth A. Mcloughlin (Plainsboro, New Jersey); James H. Cox (Princeton, New Jersey); Brett P. Fors (Ithaca, New York) |
| ABSTRACT | In one aspect, methods of depolymerization are described herein comprising providing a synthetic polymer including a hydroxylated aliphatic backbone or hydroxylated backbone segments, and homolytically activing O—H bonds of the hydroxyl groups. Homolytic activation induces the formation of alkoxy radical intermediates followed by C—C bond β-scission events breaking the polymer backbone into depolymerization products. In some embodiments, depolymerization products comprise alkyl radical intermediates reduced by hydrogen atom transfer. Moreover, in some embodiments, the depolymerization products are further reacted into difunctionalized products or comprise functionalities derived from the polymer structure. The difunctionalized products can subsequently be employed in polymerization processes for the production of additional synthetic polymers. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 18/285087 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 1/22 (20130101) C07C 29/00 (20130101) C07C 37/055 (20130101) C07C 41/18 (20130101) Original (OR) Class C07C 45/55 (20130101) C07C 51/00 (20130101) C07C 253/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/16 (20130101) C08G 69/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191053 | Moon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WASHINGTON UNIVERSITY (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Tae Seok Moon (St. Louis, Missouri); Jinjin Diao (St. Louis, Missouri); Yifeng Hu (St. Louis, Missouri); Kirsten Davis (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of methods, systems, and Rhodococcus sp. strains for the upcycling of polyethylene terephthalate) (PET). An aspect of the present disclosure provides for a system for waste PET valorization comprising: a microorganism capable of growing on PET hydrolysis products, such as PET hydrolysate. PET products from chemical hydrolysis, or alkaline hydrolysis products of PET as a carbon source. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 18/555230 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/105 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 9/90 (20130101) C12N 9/1022 (20130101) C12N 15/52 (20130101) Enzymes C12Y 202/01007 (20130101) C12Y 401/01063 (20130101) C12Y 503/03002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191132 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Li (Tempe, Arizona); Jiang Wu (Chandler, Arizona) |
| ABSTRACT | Compounds of General Formula I may harvest electrogenerated excitons via metal-assisted delayed fluorescence (MADF). The compounds have utility in light emitting diodes and light emitting devices. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/419007 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/006 (20130101) C07F 15/0086 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 2211/1007 (20130101) C09K 2211/1014 (20130101) C09K 2211/1022 (20130101) C09K 2211/1029 (20130101) C09K 2211/1044 (20130101) C09K 2211/1051 (20130101) C09K 2211/1059 (20130101) C09K 2211/1074 (20130101) Organic electric solid-state devices H10K 50/11 (20230201) H10K 85/341 (20230201) H10K 85/346 (20230201) H10K 2101/10 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191216 | Dietrich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LYGOS, INC. (BERKELEY, California) |
| ASSIGNEE(S) | LYGOS, INC. (BERKELEY, California) |
| INVENTOR(S) | Jeffrey A. Dietrich (Berkeley, California); Jeffrey L. Fortman (Berkeley, California); Eric J. Steen (Berkeley, California) |
| ABSTRACT | Systems and methods for the production of malonate in recombinant host cells. |
| FILED | Monday, March 20, 2023 |
| APPL NO | 18/123840 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 51/38 (20130101) C07C 67/08 (20130101) C07C 67/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/46 (20130101) Enzymes C12Y 301/02004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191366 | HU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leiming HU (Wheat Ridge, Colorado); Kenneth Charles NEYERLIN (Arvada, Colorado) |
| ABSTRACT | Described herein are devices and methods for the facile, efficient electrocatalytic conversion of carbon monoxide to high purity formic acid and other organic compounds. The described devices utilize perforated membranes to reduce energy requirements and extend electrochemical cell life by reducing damage caused by fluids being formed between internal ion exchange membranes. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/460186 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/07 (20210101) Original (OR) Class C25B 3/26 (20210101) C25B 9/23 (20210101) C25B 11/031 (20210101) C25B 11/052 (20210101) C25B 11/065 (20210101) C25B 11/081 (20210101) C25B 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191686 | MARTINEZ TOSSAS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis Antonio MARTINEZ TOSSAS (Boulder, Colorado) |
| ABSTRACT | A design for wind turbine rotor blades, aircraft wings, and/or other aerodynamic applications which may reduce the vorticity downstream and thus improve lift is described. The blade designs may include an increase in the blade chord towards the tip of the blade, a change in the twist angle at least once along the length of the blade, and/or a change in the thickness of the blade at least once along the length of the blade. These changes individually or in combination may allow for the creation of a counter-rotating vortex behind the blade, increasing power generation and/or lift. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/533401 |
| CURRENT CPC | Wind Motors F03D 1/0633 (20130101) Original (OR) Class Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/307 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191786 | Raymond et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William T. Radigan (Albuquerque, New Mexico); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. Raymond (Edgewood, New Mexico); William T. Radigan (Albuquerque, New Mexico) |
| ABSTRACT | A harmonic drive assembly and fluid-powered linear motors with both axial pistons are rotary piston arrangements incorporating the harmonic drive assembly are disclosed. The motors may be used in downhole drilling applications, but the drive assembly and/or motors may be used in other applications. The assembly, motors and methods use advanced harmonic drives, advanced helical drives, and combinations thereof with 1) motors with axial pistons and reciprocating linear rings to convert reciprocative axial motion to continuous rotary motion, and 2) motors with rotary pistons and reciprocating linear rings to rectify reciprocative rotary motion to continual rotary motion to improve performance over prior configurations. Axial pistons provide a robust simple solution for generating rotation; Rotational pistons provide increased torque generation as the torque generated is proportional to motor length. Since downhole drills are long, a high-torque motor can be produced using this method. |
| FILED | Monday, February 19, 2024 |
| APPL NO | 18/581178 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 4/02 (20130101) E21B 4/006 (20130101) Gearing F16H 25/06 (20130101) F16H 25/122 (20130101) Original (OR) Class F16H 49/001 (20130101) F16H 2025/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193116 | Gorni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brookhaven Science Associates, LLC (Upton, New York) |
| ASSIGNEE(S) | Brookhaven Science Associates, LLC (Upton, New York) |
| INVENTOR(S) | Dominik Stanislaw Gorni (Upton, New York); Grzegorz W. Deptuch (Upton, New York); Sandeep Miryala (Upton, New York) |
| ABSTRACT | An event-driven readout management system includes non-priority access arbitration of a plurality of channels. The system includes an arbitration tree circuit, response circuit, in-channel logic circuit, and output periphery circuit. The arbitration tree circuit determines to which of the plurality of channels to grant access to a common signal transfer resource shared by the plurality of channels based on a readout access request provided by at least one of the plurality of channels. The arbitration tree circuit terminates a prior readout transaction and commences a subsequent readout transaction in response to a single edge of a clock signal. The in-channel logic circuit terminates the prior readout transaction and commences the subsequent readout transaction in response to receiving an acknowledge token. The output periphery circuit converts information received from the plurality of channels into an output format on the common signal transfer resource. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 18/286829 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/4031 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194305 | Ong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shyue Ping Ong (San Diego, California); Jian Luo (San Diego, California); Yunxing Zuo (San Diego, California); Mingde Qin (San Diego, California); Chi Chen (San Diego, California) |
| ABSTRACT | A method for machine learning enabled material design may include applying a first machine learning model trained to generate an equilibrium crystal structure corresponding a crystal structure generated, for example, by performing an elemental substation. The first machine learning model may generate the equilibrium crystal structure by iteratively searching a solution space including possible variations of the crystal structure for a variation having a minimum formation energy. The searching may be constrained to variations having a same symmetry as the crystal structure. Properties of the crystal structure may be determined, for example, by applying a second machine learning to the equilibrium crystal structure. The crystal structure may be identified as a candidate for synthesis based the properties of the crystal structure, such as an above-threshold elastic modulus corresponding to an ultra-incompressibility. Various materials identified using this method and related systems and computer program products are also provided. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/555664 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/70 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194859 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies, Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Bogdan ZDYRKO (Atlanta, Georgia); Addison SHELTON (Atlanta, Georgia); Eugene BERDICHEVSKY (Alameda, California); Igor LUZINOV (Clemson, South Carolina); Alexander JACOBS (Oakland, California); Eerik HANTSOO (Oakland, California); George GOMES (Alameda, California) |
| ABSTRACT | A battery electrode composition is provided comprising composite particles, with each composite particle comprising active material and a scaffolding matrix. The active material is provided to store and release ions during battery operation. For certain active materials of interest, the storing and releasing of the ions causes a substantial change in volume of the active material. The scaffolding matrix is provided as a porous, electrically-conductive scaffolding matrix within which the active material is disposed. In this way, the scaffolding matrix structurally supports the active material, electrically interconnects the active material, and accommodates the changes in volume of the active material. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584334 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/38 (20130101) H01M 4/48 (20130101) H01M 4/139 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/366 (20130101) H01M 4/0402 (20130101) H01M 4/624 (20130101) H01M 4/625 (20130101) H01M 10/052 (20130101) H01M 10/054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194895 | SONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WEST VIRGINIA UNIVERSITY BOARD OF GOVERNORS ON BEHALF OF WEST VIRGINIA UNIVERSITY (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xueyan SONG (Pittsburgh, Pennsylvania); Yun CHEN (Pittsburgh, Pennsylvania) |
| ABSTRACT | In one aspect, the disclosure relates to ALD-coated cells comprising a conformal ultra-thin nanocomposite comprising Pt and CoOx on a LSCF/SDC cathode backbone. In a further aspect, the ALD-coated cells comprising an ultra-thin nanocomposite comprising Pt and CoOx on a LSCF/SDC cathode backbone are prepared using a disclosed Atomic Layer Deposition (ALD) coating method. In a still further aspect, the disclosed ALD-coated cells comprise a heterogeneous coating layer comprising subjacent discrete Pt nanoparticles capped with superjacent fully dense conformal CoOx layer. In a yet further aspect, the performance of the disclosed ALD-coated cells is improved compared to baseline cells lacking the disclosed ALD coating on a LSCF/SDC cathod backbone. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 18/287636 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/925 (20130101) H01M 4/8657 (20130101) Original (OR) Class H01M 4/8867 (20130101) H01M 4/9033 (20130101) H01M 2004/8689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194929 | Pozin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael Pozin (Brookfield, Connecticut); Walter Fred Paxton (Albuquerque, New Mexico); Bryan James Kaehr (Albuquerque, New Mexico) |
| ASSIGNEE(S) | DURACELL U.S. OPERATIONS, INC. (Wilmington, Delaware); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Michael Pozin (Brookfield, Connecticut); Walter Fred Paxton (Albuquerque, New Mexico); Bryan James Kaehr (Albuquerque, New Mexico) |
| ABSTRACT | A battery cell comprising a composite water-responsive safety layer and/or composite water- and pH-responsive safety layer to protect against tissue damage and/or electrolysis, when the battery cell is exposed to aqueous solution or tissue, is provided. The composite water-responsive safety layer and/or composite water- and pH-responsive safety layer is adapted to change from a non-electronically conducting state to an electronically conducting state. |
| FILED | Monday, January 15, 2024 |
| APPL NO | 18/412979 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0427 (20130101) Original (OR) Class H01M 50/103 (20210101) H01M 50/107 (20210101) H01M 50/109 (20210101) H01M 50/121 (20210101) H01M 50/124 (20210101) H01M 50/1245 (20210101) H01M 2200/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195166 | Mitra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Bhaskar Mitra (Cambridge, Massachusetts); Nimat Shamim (Tumwater, Washington); Sheik Mohammad Mohiuddin (Richland, Washington); Manisha Maharjan (Princeton, New Jersey); Ahmad Tbaileh (Seattle, Washington); Quan H. Nguyen (Richland, Washington); Jinho Kim (Auburn, Alabama); Nader A. Samaan (Richland, Washington) |
| ABSTRACT | Circuit breakers and associated methods are described. According to one aspect, a circuit breaker includes an input node configured to receive an AC waveform of electrical energy, an output node configured to output the AC waveform, mechanical breaker circuitry configured to selectively operate in a conductive state to conduct the AC waveform from the input node to the output node, switching circuitry configured to selectively operate in a conductive state to conduct the AC waveform from the input node to the output node, energy absorption circuitry coupled with the input node and the output node, wherein the mechanical breaker circuitry and the switching circuitry are changed from the conductive state to a non-conductive state after detection of a fault, and wherein the energy absorption circuitry is configured to dissipate electrical energy of the fault after the mechanical breaker circuitry and the switching circuitry are changed to the non-conductive state. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537542 |
| CURRENT CPC | Emergency Protective Circuit Arrangements H02H 3/021 (20130101) Original (OR) Class H02H 3/025 (20130101) H02H 3/083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195233 | Tangudu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina); Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jagadeesh K. Tangudu (South Windsor, Connecticut); Jun Cui (Ames, Iowa) |
| ABSTRACT | Aircraft electric motors include a rotor having a plurality of magnet segments arranged on a frame of the rotor, the rotor defining an internal cavity radially inward from the plurality of magnet segments, an output shaft operably coupled to the rotor, and a stator having a support structure and at least one winding wrapped about a plurality of stator teeth. The stator teeth include inner teeth arranged on a radially inward side of the support structure and outer teeth arranged on a radially outward side of the support structure and the stator is arranged within the internal cavity of the rotor. At least one of the inner teeth, the outer teeth, or the support structure is formed from a non-magnetic material with embedded magnetic wires. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/486912 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) Dynamo-electric Machines H02K 1/02 (20130101) Original (OR) Class H02K 1/16 (20130101) H02K 1/2786 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195352 | STRADINS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pauls STRADINS (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to a photovoltaic (PV) system that includes a plurality of interconnected sections, where each section includes a PV element and a reflective surface, where at least two sections have a folded state and an unfolded state, and each section is configured to be switched between the folded state and the unfolded state. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/532567 |
| CURRENT CPC | Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 30/20 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195402 | Kanale et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ajit Kanale (Raleigh, North Carolina); Suyash Sushilkumar Shah (Raleigh, North Carolina); Bantval Jayant Baliga (Raleigh, North Carolina); Subhashish Bhattacharya (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to overcurrent protection for composite power semiconductor switches comprising a high voltage power switch in series with a low voltage non-linear element. In one example, a system includes a blocking diode connected to a sensing node of a composite switching device; a resistor connected in series with the blocking diode and to a desaturation detection input of a gate driver circuit; and a blanking capacitor connected between the desaturation detection input and a common voltage reference of the gate driver circuit. The gate driver circuit can detect a short circuit condition based upon a sensed voltage at the desaturation detection input. In another example, a method includes sensing a voltage on a blanking capacitor, the voltage provided from a sensing node of a composite switching device via a blocking diode and a resistor, and detecting a short circuit condition based upon the sensed voltage. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535753 |
| CURRENT CPC | Pulse Technique H03K 17/0828 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240189263 | Krishnan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota); AGNI Medical LLC (Jacksonville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunil Krishnan (Ponte Vedra Beach, Florida); Yuri Mackeyev (Jacksonville, Florida); Elena Vishnyakova (Pompano Beach, Florida) |
| ABSTRACT | This document provides derivatized C60 molecules (e.g., C60-serinol) and methods and materials for using derivatized C60 molecules (e.g., C60-serinol) to reduce radiation injury. For example, methods and materials for using derivatized C60 molecules (e.g., C60-serinol) to reduce, prevent, and/or mitigate radiation injury (e.g., radiation induced oxidative stress and/or DNA damage) to cells (e.g., human cells) or to a mammal (e.g., a human) during, for example, outer space missions are provided. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 18/286297 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240190066 | Gandhiraman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITIES SPACE RESEARCH ASSOCIATION (Columbia, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramprasad Gandhiraman (Sunnyvale, California); Meyya Meyyappan (Pacifica, California); Jessica E. Koehne (Portola Valley, California) |
| ABSTRACT | A device and method for printing 3D articles including electronic and functional elements including 3D printer and a plasma jet printer based on a dielectric barrier atmospheric pressure plasma jet system in which both printing and in-situ treatment and post-deposition treatment can be carried out to tailor the materials characteristics. Plasma jet printer comprising of electrodes in the nozzle/print head for applying electric field and generating atmospheric plasma that could be used for non-gravity based highly directional printing in any direction. Integration of dielectric barrier plasma printer and plasma treatment jets with the 3D printer increases the capability of embedding high performance electronics in a 3D printed structure aiding in additive manufacturing of functional devices. Ability to use a range of materials for print head assembly including micro machined silicon increases the resolution of the plasma jet printer to sub-micron level. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/544634 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/25 (20210101) B22F 10/50 (20210101) B22F 10/60 (20210101) B22F 12/22 (20210101) B22F 12/53 (20210101) B22F 12/55 (20210101) B22F 12/70 (20210101) B22F 12/82 (20210101) B22F 2202/13 (20130101) B22F 2999/00 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Original (OR) Class B29C 64/188 (20170801) B29C 64/205 (20170801) B29C 64/209 (20170801) B29C 64/321 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191817 | Ross et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Ross (Edwards, California); Eric J. Miller (Lancaster, California); Shideh Naderi (Palmdale, California); Paul Bean (Lancaster, California); Jonathan Lopez-Zepeda (Edwards, California); Francisco Pena (Edwards, California) |
| ABSTRACT | A magnetic coupling system that includes a first housing disposed about an end of a first conduit. The first housing includes an axially-extending annular flange. A first annular magnetic element, coupled to the first housing and concentric with the annular flange, has a first plurality of magnetic polarities disbursed thereabout. A second housing, disposed about an end of a second conduit, includes an axially-extending annular channel for engagement with the annular flange. A second annular magnetic element is coupled to the second housing and is concentric with the annular channel. An air gap is disposed between the first annular magnetic element and the second annular magnetic element when the annular flange is engaged in the annular channel. The second annular magnetic element has a second plurality of magnetic polarities disbursed thereabout. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/387929 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 37/004 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192081 | SUNG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland); NATIONAL AERONAUTICS AND SPACE ADMINISTRATION LANGLEY RESEARCH CENTER (Hampton, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Myung K. SUNG (Baltimore, Maryland); Soobum Lee (Baltimore, Maryland); Jude Persia (Baltimore, Maryland); Devin E. Burns (Hampton, Virginia) |
| ABSTRACT | This present disclosure is about a wind tunnel balance axial section. A wind tunnel balance is a sensor that measures six force/moment components from a test model in a wind tunnel. An axial section, one of the six measurement sections in the balance, is the hardest section to design because it is often required to measure an axial force which is much smaller than other force components. Therefore, there is a specific design requirement for the axial section to selectively amplify the axial force response and suppress the non-axial responses. This disclosure presents a sensor mechanism composed of elastic linkages to achieve this design requirements for the axial section. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/539064 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/2262 (20130101) G01L 1/2287 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 9/062 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193116 | Gorni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brookhaven Science Associates, LLC (Upton, New York) |
| ASSIGNEE(S) | Brookhaven Science Associates, LLC (Upton, New York) |
| INVENTOR(S) | Dominik Stanislaw Gorni (Upton, New York); Grzegorz W. Deptuch (Upton, New York); Sandeep Miryala (Upton, New York) |
| ABSTRACT | An event-driven readout management system includes non-priority access arbitration of a plurality of channels. The system includes an arbitration tree circuit, response circuit, in-channel logic circuit, and output periphery circuit. The arbitration tree circuit determines to which of the plurality of channels to grant access to a common signal transfer resource shared by the plurality of channels based on a readout access request provided by at least one of the plurality of channels. The arbitration tree circuit terminates a prior readout transaction and commences a subsequent readout transaction in response to a single edge of a clock signal. The in-channel logic circuit terminates the prior readout transaction and commences the subsequent readout transaction in response to receiving an acknowledge token. The output periphery circuit converts information received from the plurality of channels into an output format on the common signal transfer resource. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 18/286829 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/4031 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194888 | Laicer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Castro Laicer (Acton, Massachusetts); Mario Moreira (Hudson, Massachusetts); Katherine Harrison (Arlington, Massachusetts) |
| ABSTRACT | An electrochemical device includes a cathode, an anode, a separator, and an electrolyte in fluid communication with the cathode, the anode, and the separator, wherein at least one of the cathode, the anode, and the separator is coated with at least one of a blend and a multilayer film of an MXene-polymer composite material. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/286819 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/48 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/366 (20130101) H01M 4/382 (20130101) H01M 4/624 (20130101) H01M 4/628 (20130101) Original (OR) Class H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 50/414 (20210101) H01M 50/431 (20210101) H01M 50/446 (20210101) H01M 50/449 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194955 | Laicer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Castro Laicer (Action, Massachusetts); Pavithra Murugavel Shanthi (Natick, Massachusetts); Katherine Harrison (Arlington, Massachusetts) |
| ABSTRACT | An electrolyte includes a lithium (Li) salt, a fluorinated solvent, a 1,3-dioxaolane (DOL) solvent, a 1,2-dimethyoxyethane (DME) solvent, a lithium polysulfide (LiPS), and a lithium nitrate (LiNO3). Lithium sulfur electrochemical devices, such as lithium electrochemical cells and lithium-sulfur batteries, such as lithium-sulfur rechargeable (secondary) batteries include an electrolyte that includes a lithium (Li) salt, a fluorinated solvent, a 1,3-dioxaolane (DOL) solvent, a 1,2-dimethyoxyethane (DME) solvent, a lithium polysulfide (LiPS), and a lithium nitrate (LiNO3). |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/286863 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0565 (20130101) H01M 10/0567 (20130101) H01M 10/0569 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 2300/0037 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240189293 | Citron |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce Citron (East Orange, New Jersey) |
| ABSTRACT | The disclosure relates to compositions and methods of treating Gulf War illness or syndrome in a subject. The method comprises administering to a subject in need of treatment an effective amount of a nuclear receptor peroxisome proliferator-activated receptor gamma agonist and a nuclear factor erythroid 2-related factor 2 agonist. |
| FILED | Thursday, July 06, 2023 |
| APPL NO | 18/347811 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/4439 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189304 | Gao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Ohio State Innovation Foundation (Columbus, Ohio); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Allen C. Gao (Davis, California); Pui-Kai Li (Columbus, Ohio); Mark Foster (Columbus, Ohio); Ross Larue (Columbus, Ohio); Cameron M. Armstrong (Davis, California); Wei Lou (Davis, California); Shu Ning (Davis, California); Enming Xing (Columbus, Ohio) |
| ABSTRACT | Methods for the treatment of condition associated with bromodomain and extraterminal domain (BET) protein activity are disclosed. The methods include administering a therapeutically effective amount of a piperazine BET protein inhibitor or a piperidine BET protein inhibitor to a subject in need thereof. Piperazine BET protein inhibitors, piperidine BET protein inhibitors, and pharmaceutical compositions comprising the BET proteins inhibitors are also described. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 18/548844 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4166 (20130101) A61K 31/4439 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/12 (20130101) C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240189455 | Choudhary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav Choudhary (Providence, Rhode Island); Peng Zhang (Providence, Rhode Island) |
| ABSTRACT | Disclosed are nucleic acid sequences comprising a cardiomyocyte-specific, cardiac stress-induced promoter operably linked to a mitochondrial targeting sequence (MTS) and/or a gene of interest. Disclosed are vectors comprising one or more of the disclosed nucleic acids. Disclosed are methods of using the disclosed nucleic acid sequences or vectors for treating a subject in need thereof. Disclosed are methods of treating pulmonary hypertension (PH) in a subject comprising administering a therapeutically effective amount of a vector to the subject, wherein the vector comprises a nucleic acid sequence comprising a cardiomyocyte-specific, cardiac stress-induced promoter operably linked to a mitochondrial targeting sequence (MTS) and/or a gene that encodes a PH therapeutic, wherein the PH therapeutic is expressed in cardiomyocytes undergoing cardiac stress. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/533784 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 9/1029 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2840/007 (20130101) Enzymes C12Y 203/01016 (20130101) C12Y 207/10002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240191238 | Wyss-Coray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government As Represented By the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton Wyss-Coray (Palo Alto, California); Thomas A. Rando (Stanford, California); Markus Britschgi (Allscwil, Switzerland); Kaspar Rufibach (Basel, Switzerland); Saul A. Villeda (Lancaster, California) |
| ABSTRACT | Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/587147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/7088 (20130101) A61K 38/19 (20130101) A61K 38/45 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/24 (20130101) C07K 16/28 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2799/06 (20130101) C12N 2799/022 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) Enzymes C12Y 207/10001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240189090 | SICOTTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zenflow, Inc. (Palo Alto, California) |
| ASSIGNEE(S) | Zenflow, Inc. (Palo Alto, California) |
| INVENTOR(S) | Marcel Song SICOTTE (San Francisco, California); Austin Michael BLY (San Clemente, California); Ben COLLETT-NYE (Kumeu, New Zealand); Shreya MEHTA (San Francisco, California) |
| ABSTRACT | Systems, devices, and methods are provided for the delivery of an implant into the prostatic urethra. Embodiments of delivery systems can include a delivery device for insertion into the patient and a proximal control device for use in controlling release of the implant from the delivery device. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/444381 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3468 (20130101) A61B 2017/00274 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/042 (20130101) Original (OR) Class A61F 2/885 (20130101) A61F 2/966 (20130101) A61F 2002/047 (20130101) A61F 2250/001 (20130101) Gearing F16H 1/06 (20130101) F16H 1/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193452 | LESTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Atom Computing Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian LESTER (Berkeley, California); Benjamin BLOOM (Boulder, Colorado); Krish KOTRU (Berkeley, California); Jonathan KING (Berkeley, California); Mickey MCDONALD (Boulder, Colorado); Mark STONE (Berkeley, California) |
| ABSTRACT | In an aspect, the present disclosure provides a method comprising providing a plurality of atoms. At least one atom of the plurality of atoms may have a different state than one or more other atoms of the plurality of atoms. The at least one atom may be excited to an excited state. The exciting may be performed using a non-site selective excitation beam over the plurality of atoms that only interacts with the at least one atom. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508585 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194888 | Laicer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Castro Laicer (Acton, Massachusetts); Mario Moreira (Hudson, Massachusetts); Katherine Harrison (Arlington, Massachusetts) |
| ABSTRACT | An electrochemical device includes a cathode, an anode, a separator, and an electrolyte in fluid communication with the cathode, the anode, and the separator, wherein at least one of the cathode, the anode, and the separator is coated with at least one of a blend and a multilayer film of an MXene-polymer composite material. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/286819 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/48 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/366 (20130101) H01M 4/382 (20130101) H01M 4/624 (20130101) H01M 4/628 (20130101) Original (OR) Class H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 50/414 (20210101) H01M 50/431 (20210101) H01M 50/446 (20210101) H01M 50/449 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240194955 | Laicer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Castro Laicer (Action, Massachusetts); Pavithra Murugavel Shanthi (Natick, Massachusetts); Katherine Harrison (Arlington, Massachusetts) |
| ABSTRACT | An electrolyte includes a lithium (Li) salt, a fluorinated solvent, a 1,3-dioxaolane (DOL) solvent, a 1,2-dimethyoxyethane (DME) solvent, a lithium polysulfide (LiPS), and a lithium nitrate (LiNO3). Lithium sulfur electrochemical devices, such as lithium electrochemical cells and lithium-sulfur batteries, such as lithium-sulfur rechargeable (secondary) batteries include an electrolyte that includes a lithium (Li) salt, a fluorinated solvent, a 1,3-dioxaolane (DOL) solvent, a 1,2-dimethyoxyethane (DME) solvent, a lithium polysulfide (LiPS), and a lithium nitrate (LiNO3). |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/286863 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0565 (20130101) H01M 10/0567 (20130101) H01M 10/0569 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 2300/0037 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240189118 | PELZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Joshua PELZ (San Diego, California); Luca DE VIVO (San Diego, California); Falko KUESTER (La Jolla, California); Herbert J. BARRACK (San Diego, California) |
| ABSTRACT | A transtibial prosthetic device comprises a pylon configured as a unitary truss structure formed of a plurality of elongated supports interconnected at nodes and having open spaces between supports of the plurality of elongated supports. The unitary truss structure comprises a polymer. A foot-ankle complex extends from a base of the pylon. The foot-ankle complex comprises an s-shaped posterior portion, an s-shaped anterior portion, and a sole portion. The s-shaped posterior portion and the s-shaped anterior portion both extend from the sole portion, have upper portions with curvatures that are concentric with each other, and are separated from each other by a gap. |
| FILED | Monday, February 19, 2024 |
| APPL NO | 18/581180 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) Original (OR) Class A61F 2/80 (20130101) A61F 2/5046 (20130101) A61F 2/6607 (20130101) A61F 2002/505 (20130101) A61F 2002/607 (20130101) A61F 2002/6621 (20130101) A61F 2002/6642 (20130101) A61F 2002/6685 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195727 | Yuksel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Murat Yuksel (Orlando, Florida); Ammar Farooq (Orlando, Florida) |
| ABSTRACT | A system and method for disconnection tolerant network routing, termed Binary State Distance Vector Routing (BSDVR). BSDVR provides for unicast routing on partitioned networks by introducing binary state information for distance vector (DV) entries to compute unicast paths. In the presence of network partitions, BSDVR effectively avoids the count-to-infinity problem and operates with control overhead less than traditional DV routing by an order of magnitude, leading to much better convergence times for failures. |
| FILED | Friday, May 05, 2023 |
| APPL NO | 18/312975 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/22 (20130101) H04L 45/28 (20130101) H04L 45/123 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240192671 | Shiu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leung Man Shiu (Gaithersburg, Maryland); Erich Joseph Petre (Gainesville, Virginia) |
| ABSTRACT | Systems and methods for commanding, controlling, and guiding automated guided vehicles (“AGVs”). Automated systems translate AGV commands according to AGV manufacturers. AGVs can be summoned and destinations be determined automatically. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/587554 |
| CURRENT CPC | Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 1/1371 (20130101) B65G 1/1378 (20130101) B65G 2203/041 (20130101) B65G 2203/042 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/04 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/41895 (20130101) Original (OR) Class G05B 2219/40298 (20130101) G05B 2219/45063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240193535 | Turner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alison Frankowski Turner (Arlington, Virginia); Marc D. McCrery (Arlington, Virginia); James J. Boldt (Leesburg, Virginia) |
| ABSTRACT | Methods and systems for coordinating item delivery are disclosed. In one aspect, a method comprises receiving delivery route data from a carrier device, generating, based on the delivery route data, a digital route for a delivery resource, the digital route comprising a street portion and an office portion, wherein the street portion comprises: a plurality of delivery points at which the carrier is to perform a service, and a segmented travel course for the carrier to travel to each of the plurality of delivery points in a determined sequence, and wherein the office portion comprises details regarding one or more office activities performed by the carrier to prepare for or conclude the street portion of a delivery route. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/424568 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0838 (20130101) G06Q 10/08355 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 20240188927 | Yarmush et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin L. Yarmush (Newton, Massachusetts); Alvin Chen (Cambridge, Massachusetts); Max Balter (Boston, Massachusetts); Joshua Leipheimer (Highland Park, New Jersey) |
| ABSTRACT | A device and method for directing a cannula toward a target location under a patient's skin. The device is handheld and the device operations may be automated. The device includes an imaging probe for imaging the target location, a positioning unit for manipulating a cannula towards the target location, and a processor. The processor receives imaging data from the imaging probe, cannula pose data from at least one cannula position sensor, and device pose data from at least one device position sensor. The target location is identified from the imaging data, and a trajectory for manipulating the cannula towards the target location is determined based on the imaging data, the cannula pose data, and the device pose data. The processor may determine that the trajectory becomes misaligned with the target position, and may update to a corrected trajectory based on the imaging data, cannula pose data, and device pose data. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/586675 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/12 (20130101) A61B 8/466 (20130101) A61B 8/0841 (20130101) Original (OR) Class A61B 8/4218 (20130101) A61B 2034/2065 (20160201) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240193916 | Fry |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark Fry (Marco Island, Florida) |
| ABSTRACT | Systems and methods of detecting a vortex made by a travelling object is disclosed. Techniques include positioning a media collector to capture a visual media file of the vortex. In some configurations, a graphic recognition algorithm and vortex similarity engine are used to determine whether a visual media file captured by a media collector contains a vortex. In some configurations, a computer may trigger an alert if a travelling object vortex is not expected to be in the visual media file. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/422997 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/761 (20220101) G06V 10/764 (20220101) Original (OR) Class G06V 20/52 (20220101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/182 (20130101) Traffic Control Systems G08G 5/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20240191311 | Lu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | USA, represented by Administrator of the U.S. EPA (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States Government, as represented by the Administrator of the U.S. EPA (Washington, District of Columbia) |
| INVENTOR(S) | Jingrang Lu (Mason, Ohio) |
| ABSTRACT | This invention is at least one panel of qPCR/RT-qPCR assays which enables simultaneous testing for the presence of multiple species and subgroups of cyanobacteria that produce microcystin, anatoxin, saxitoxin, and cylindrospermopsin cyanotoxins. The method takes into account that some cyanobacteria species may carry genes associated with multiple toxin types. Testing for each toxin type is conducted under standardized test conditions which allow quantification of the number of gene copies present for cyanotoxins which may contribute to the overall toxin level. |
| FILED | Wednesday, September 26, 2018 |
| APPL NO | 16/142319 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20240193097 | Kotra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | Jagadish B. Kotra (Austin, Texas); John Kalamatianos (Arlington, Massachusetts) |
| ABSTRACT | Address translation is performed to translate a virtual address targeted by a memory request (e.g., a load or memory request for data or an instruction) to a physical address. This translation is performed using an address translation buffer, e.g., a translation lookaside buffer (TLB). One or more actions are taken to reduce data access latencies for memory requests in the event of a TLB miss where the virtual address to physical address translation is not in the TLB. Examples of actions that are performed in various implementations in response to a TLB miss include bypassing level 1 (L1) and level 2 (L2) caches in the memory system, and speculatively sending the memory request to the L2 cache while checking whether the memory request is satisfied by the L1 cache. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/064155 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0897 (20130101) G06F 12/1045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240191321 | Sherman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Terves, LLC (Euclid, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Sherman (Mentor, Ohio); Nicholas Farkas (Euclid, Ohio) |
| ABSTRACT | The present disclosure relates to a low temperature, semi-continuous process for producing high purity rare earth metals and alloys in molten salts. Rare earth metals and alloys are reduced from the corresponding rare earth halide in molten salts in a semi-continuous process. An air stable pellet or ingot can be fed into molten salts and reduced through metallothermic reduction or electrolysis. The formation of an air stable feedstock minimizes handling concerns of the hygroscopic rare earth salts, allowing the reduction process to be run in a semi-continuous process. The process can optionally include the addition of alloying elements such as magnesium, iron and zinc reduce the required processing temperature. |
| FILED | Friday, July 07, 2023 |
| APPL NO | 18/219322 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 5/02 (20130101) Original (OR) Class C22B 59/00 (20130101) Alloys C22C 28/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240192574 | Puckett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Matthew Wade Puckett (Phoenix, Arizona); Chad Fertig (Roseville, Minnesota); Matthew Robbins (Minneapolis, Minnesota); Jad Salman (Wayzata, Minnesota) |
| ABSTRACT | A nonlinear wave mixing system with grating assisted phase matching is provided. The system includes a pump laser and a nonlinear waveguide. The pump laser is used to generate pump light at a select wavelength. The nonlinear waveguide is configured to generate produced light from the pump light that is directed into the nonlinear waveguide. The nonlinear waveguide includes at least one backward grating that is configured to diffract the produced light in a backward direction relative to a direction the produced light travels in the nonlinear waveguide to reach the backward grating. The backward grating having a grating momentum that generates counter-propagating phase matching in the produced light. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584710 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3548 (20210101) Original (OR) Class G02F 1/3775 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0092 (20130101) H01S 3/109 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240195414 | BALLARD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CODY JAMES BALLARD (Catonsville, Maryland); JOEL D. STRAND (Ellicott City, Maryland); THOMAS BERNHARD CHAMBERLIN (Baltimore, Maryland) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | CODY JAMES BALLARD (Catonsville, Maryland); JOEL D. STRAND (Ellicott City, Maryland); THOMAS BERNHARD CHAMBERLIN (Baltimore, Maryland) |
| ABSTRACT | One example includes a superconducting current control system. The system includes an inductive coupler comprising a load inductor and a control inductor. The inductive coupler can be configured to inductively provide a control current from the control inductor to a superconducting circuit device based on a load current being provided through the load inductor. The system also includes a current control element comprising a superconducting quantum interference device (SQUID) array comprising a plurality of SQUIDs. The current control element can be coupled to the inductive coupler to control an amplitude of the load current through the load inductor, and thus to control an amplitude of the control current to the superconducting circuit device. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063518 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/04 (20130101) Pulse Technique H03K 17/92 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, June 13, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240613.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page