FedInvent™ Patent Applications
Application Details for Thursday, June 20, 2024
This page was updated on Friday, June 21, 2024 at 05:20 PM GMT
Department of Health and Human Services (HHS)
| US 20240197166 | German et al. |
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| FUNDED BY |
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| APPLICANT(S) | CFD Research Corporation (Huntsville, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carrie Lynn German (Huntsville, Alabama); Balabhaskar Prabhakarpandian (Madison, Alabama); Ketan Harendrakumar Bhatt (Huntsville, Alabama) |
| ABSTRACT | The method involves computationally modeling a cornea by simulating physical cornea models with computational in silico models. The simulated data is compared with actual data from the physical models, and the simulation is iterated until a match is achieved. The method may also include calibrating diffusion parameters for testing substances, and configuring the models for analyzing instances of fluid-induced shear and substance transport. The simulated data may be used to obtain corneal pharmacokinetic models, and the method may be used to obtain predictions for time-dependent concentrations of molecules in the eye or systemic circulation. The computational models may consider instances of convective-diffusive transport and carrier-mediated transport in calculations and determinations of transport characteristics and values of different testing substances. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/542002 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 15/00 (20130101) G06T 2207/30024 (20130101) G06T 2207/30041 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197262 | Epstein et al. |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederick H. Epstein (Charlottesville, Virginia); Yu Wang (Charlottesville, Virginia); Changyu Sun (Columbia, Missouri) |
| ABSTRACT | An exemplary method and system are disclosed that employ deep learning neural-network(s) trained with displacement-encoded imaging data (i.e., DENSE data) to estimate intramyocardial motion from cine MRI images retrieved with balanced steady state free precession sequences (bFSSP) and other cardiac medical imaging modalities, including standard cardiac computer tomography (CT) images, magnetic resonance imaging (MRI) images, echocardiogram images, heart ultrasound images, among other medical imaging modalities described herein. The deep learning neural-network(s) can be trained using (i) contour motion data from displacement-encoded imaging magnitude data as inputs to the neural network and (ii) displacement maps derived from displacement-encoded imaging phase images for comparison to the outputs of the neural network for neural network adjustments during the training. The DENSE trained neural network can be used to calculate tissue displacement from bFSSP cine images. |
| FILED | Thursday, September 21, 2023 |
| APPL NO | 18/472215 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7267 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/44 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197640 | Hodgkinson et al. |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Conrad P. Hodgkinson (Durham, North Carolina); Hualing Sun (Durham, North Carolina); Victor J. Dzau (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes, in part, exosomes comprising miRNA for the reprogramming of fibroblasts and methods of using the same. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/474697 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5068 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) C12N 15/113 (20130101) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197643 | CHUNG YOO et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Eun Ji Paige CHUNG YOO (Los Angeles, California); Jonathan WANG (Los Angeles, California); Yi HUANG (Los Angeles, California); Alysia COX (Los Angeles, California) |
| ABSTRACT | A drug delivery system for oral administration is provided. The drug delivery system includes an oral delivery carrier and a plurality of micelles attached to or dispersed in the oral delivery carrier. Each of the micelles includes a hydrophobic core and a hydrophilic corona targeted to a subject's kidney. A pharmaceutical payload is carried by the plurality of micelles. Another drug delivery system includes a plurality of micelles and a payload within each micelle. Each micelle has a kidney targeting peptide conjugated thereto with a polyethylene glycol linking group having a molecular weight less than 1800 Daltons. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/998618 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 9/5161 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/66 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197678 | You et al. |
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| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); YEDA RESEARCH AND DEVLOPMENT CO. LTD. (Rehovot, Israel) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); YEDA RESEARCH AND DEVLOPMENT CO. LTD. (Rehovot, Israel) |
| INVENTOR(S) | Inchul You (Boston, Massachusetts); Nathanael S. Gray (Stanford, California); Tinghu Zhang (Brookline, Massachusetts); Sirano Dhe-Paganon (Holliston, Massachusetts); Nir London (Rehovot, Israel); Christian Dubiella (Rehovot, Israel) |
| ABSTRACT | Disclosed are compounds which inhibit Pin1 activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysregulated Pin1 activity. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 18/281861 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/519 (20130101) Heterocyclic Compounds C07D 333/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197681 | CLARK et al. |
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| FUNDED BY |
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| APPLICANT(S) | Terran Biosciences Inc. (New York, New York); University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sam CLARK (New York, New York); Scott THOMPSON (Baltimore, Maryland) |
| ABSTRACT | Provided herein are compositions relating to psychedelics and serotonin receptor modulators. Further provided herein are methods of treating a disease or disorder (e.g., depression or diseases or disorders related to depression) comprising administering psychedelics and serotonin receptor modulators. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 18/553170 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/20 (20130101) A61K 31/44 (20130101) A61K 31/137 (20130101) A61K 31/522 (20130101) A61K 31/675 (20130101) A61K 31/4045 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/24 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197682 | Prusiner et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Stanley B. Prusiner (San Francisco, California); Nick A. Paras (San Francisco, California); Jay Conrad (San Francisco, California); Ny Sin (San Francisco, California); Sandeep Raikar (San Francisco, California); Mark Vander Wal (San Francisco, California); Jean-Marc M. Grandjean (San Francisco, California); Shigeo Yamanoi (San Francisco, California); Masahiro Inoue (San Francisco, California); Shimpei Hirano (San Francisco, California); Masatoshi Honzumi (San Francisco, California); Osamu Iwamoto (San Francisco, California); Koji Sasaki (San Francisco, California); Yamato Suzuki (San Francisco, California); Atsushi Tengeiji (San Francisco, California); Daniel R. Southworth (San Francisco, California); Darren Hutt (San Francisco, California); Jacob I. Ayers (San Francisco, California); Steven H. Olson (San Francisco, California); Cuong Quoc Ly (San Francisco, California); John West (San Francisco, California); Gregory E. Merz (San Francisco, California); Helene Viart (San Francisco, California) |
| ABSTRACT | A method of inhibiting propagation of protein misfolding associated with a neurological disease, is carried out by contacting an environment populated with a propagating amyloid conformation of a protein (prion) associated with a neurological disease with molecules which binds multiple adjacent sites of the protein assemblies and allowing the molecules to bind multiple cites of the protein assemblies; and thereby impeding propagation of the disease-associated conformation of the protein in the environment. Drug/prion complexes are formed and uses of the drugs in detection and treatment of neurodegenerative diseases are disclosed. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468657 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/497 (20130101) A61K 31/499 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4162 (20130101) Original (OR) Class A61K 31/4245 (20130101) A61K 31/4375 (20130101) A61K 31/4725 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197711 | Nyati et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mukesh K. Nyati (Superior Township, Michigan); Ranjit Kumar Mehta (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are methods of treating a cancer comprising administering an EGFR degrader to a patient suffering therefrom and subjecting the patient to radiation. The cancer can express mutant, overexpressed or overly activated EGFR, mutant KRAS, or mutant BRAF. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 18/284892 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197712 | Martinelli |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elena Martinelli (Evanston, Illinois) |
| ABSTRACT | Disclosed are methods of treating immunodeficiency virus infection that include methods of treating latent immunodeficiency virus infection in immune cells using a TGF-β inhibitor with antiretroviral therapy. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/515196 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197725 | YANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wentian YANG (Pawtucket, Rhode Island); Lijun WANG (Providence, Rhode Island); Douglas C. MOORE (Barrington, Rhode Island) |
| ABSTRACT | Described herein are compositions and methods for the prevention or treatment of osteoarthritis by administrating a therapeutically effective amount of at least one SHP2 antagonistic agent to the subject. The SHP2 antagonistic agent can be a SHP2 inhibitor, a PROTAC degrader of SHP2 proteins, and/or a SHP2 RNA interference or a small interfering RNA, or a combination thereof. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 18/287701 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/497 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197736 | YEAGER et al. |
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| FUNDED BY |
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| APPLICANT(S) | MEZZION PHARMA CO., LTD. (Seoul, South Korea); THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JAMES L. YEAGER (LAKE FOREST, Illinois); DAVID J. GOLDBERG (PHILADELPHIA, Pennsylvania); STEPHEN M. PARIDON (STRAFFORD, Pennsylvania) |
| ABSTRACT | Various methods and compositions for treating single ventricle heart disease (SVHD) patients, including patients who have undergone Fontan surgery and who have Fontan circulation (Fontan patient), to improve exercise performance, single ventricular performance, cardiac output and myocardial performance index (MPI) in the SVHD patients, including the Fontan patients, using udenafil compositions. In one exemplary embodiment, the methods of the present invention include administering an effective amount of udenafil or a pharmaceutically acceptable salt thereof to a SVHD patient, including a Fontan, to improve the ventricular performance of the SVHD patient's, including the Fontan patient's, single functioning ventricle. In another exemplary embodiment, the methods of the present invention include administering an effective amount of udenafil or a pharmaceutically acceptable salt thereof to a SVHD patient, including a Fontan patient, to improve the SVHD patient's, including the Fontan patient's, MPI. In still another exemplary embodiment, the methods of the present invention include administering an effective amount of udenafil or a pharmaceutically acceptable salt thereof to a SVHD patient, including a Fontan patient, to improve the SVHD patient's, including the Fontan patient's, cardiac output. In yet another exemplary embodiment, the methods of the present invention include administering an effective amount of udenafil or a pharmaceutically acceptable salt thereof to a SVHD patient, including a Fontan patient, who is about 6 years of age or older, to improve at least one or more or all of the following in the SVHD patient, including the Fontan patient: (a) ventricular performance of the SVHD patient's, including a Fontan patient's, single functioning ventricle as measured by MPI; (b) exercise capacity as measured by oxygen consumption at anaerobic threshold (VAT); (c) exercise capacity as measured by oxygen consumption at maximal effort or max VO2; (d) work rate at VAT; (e) VE/VCO2 at VAT; diastolic blood pressure at rest; and (g) oxygen saturation (%) at rest. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 16/938642 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/284 (20130101) A61K 9/2009 (20130101) A61K 9/2013 (20130101) A61K 9/2018 (20130101) A61K 9/2054 (20130101) A61K 9/2059 (20130101) A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197738 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); Atomwise Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pengda Liu (Chapel Hill, North Carolina); Siyuan Su (Chapel Hill, North Carolina); Ian Jonathan Davis (Chapel Hill, North Carolina); Christian Laggner (San Franciso, California) |
| ABSTRACT | Disclosed are compositions for targeting 0TUD7A, the compositions having a component sufficient to block and/or reduce OTUD7A-mediated deubiquitination of EWS-FLI1 in a cell. The component can be 7Ai and variants thereof. The compositions can be used to treat Ewing sarcoma (EWS). Methods of using the disclosed compositions are also disclosed, including methods of treating EWS in a subject.t |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 18/284416 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197744 | SHARIFI |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nima SHARIFI (Cleveland, Ohio) |
| ABSTRACT | The present invention provides methods, kits, and compositions for treating sex steroid dependent cancer using BMX inhibitors. In certain embodiments, a sample from a subject having, or suspected of having, a sex steroid dependent disease cancer, is further assayed to determine: i) if the subject is heterozygous or homozygous for the HSD3B1(1245C) allele that encodes for the 3βSD1(367T) protein. In some embodiments, the BMX inhibitor comprises a monoclonal antibody or BMX binding portion thereof (e.g., zanubrutinib, acalabrutinib, abivertinib or ibrutinib). |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 18/557011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/4985 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2333/904 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197750 | Griffith et al. |
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| APPLICANT(S) | QPEX Biopharma, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David C. Griffith (San Diego, California); Olga Lomovskaya (San Diego, California); Elizabeth E. Morgan (San Diego, California); Jeffery S. Loutit (San Diego, California) |
| ABSTRACT | Disclosed herein are dosing regimens of ceftibuten in combination with a β-lactamase inhibitor. The dosing regimens include ceftibuten at a dose higher than 400 mg per day (for example, 400 mg BID, 600 mg QD or BID, or 800 mg QD or BID). |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 18/553769 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 31/546 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197775 | Liang et al. |
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| APPLICANT(S) | Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Olin Liang (Chestnut Hill, Massachusetts); Eui-Young So (East Greenwich, Rhode Island); Anthony Reginato (West Roxbury, Massachusetts) |
| ABSTRACT | Described herein are compositions and methods for the prevention or treatment of rheumatoid arthritis (RA). In some embodiments, RA is prevented or treated by (i) extracting peripheral blood mononuclear cells (PBMCs) and/or bone marrow mononuclear cells (BMMCs) from a subject at risk of, or afflicted with, RA; (ii) exposing the PBMCs/BMMCs to an effective amount of one or more SHIP-1 inhibitor and/or a pan-SHIP1/2 inhibitor to induce ex vivo expansion of the subject's myeloid derived suppressor cells (MDSCs); and (iii) administering intravenously to the subject a therapeutically effective number of MDSCs. |
| FILED | Monday, April 04, 2022 |
| APPL NO | 18/285649 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197790 | Payne et al. |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Payne (Pittsburgh, Pennsylvania); Ronald Jankowski (Pittsburgh, Pennsylvania); Ryan Pruchnic (Pittsburgh, Pennsylvania); Michael B. Chancellor (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction into a site of soft tissue. Also provided are methods of isolating MDCs. The invention further provides methods of using compositions comprising MDCs for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to uses of MDCs for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the novel use of MDCs for the increase of skeletal muscle. |
| FILED | Monday, July 10, 2023 |
| APPL NO | 18/349566 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/12 (20130101) A61K 35/34 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0658 (20130101) C12N 5/0659 (20130101) C12N 2500/84 (20130101) C12N 2501/70 (20130101) C12N 2510/00 (20130101) C12N 2510/02 (20130101) C12N 2533/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197795 | Kaddurah-Daouk et al. |
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| FUNDED BY |
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| APPLICANT(S) | Boadie DUNLOP (Atlanta, Georgia); Oliver FIEHN (Davis, California); Christopher Robert BRYDGES (Davis, California); DUKE UNIVERSITY (Durham, North Carolina); EMOORY UNIVERSITY (Atlanta, Georgia); UNIVERSITY OF CALIFORNIA, DAVIS (Davis, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rima F. Kaddurah-Daouk (Durham, North Carolina); Augustus John Rush, JR. (Durham, North Carolina); Boadie W. Dunlop (Atlanta, Georgia); Oliver Fiehn (Davis, California); Christopher R. Brydges (Davis, California); W. Edward Craighead (Atlanta, Georgia); Helen Mayberg (Atlanta, Georgia) |
| ABSTRACT | Described herein are methods of identifying, characterizing, and treating depression and anxiety in a subject by modulating indoles associated with tryptophan metabolism in the subject and subject's gut microbiome. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 18/006940 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/742 (20130101) Original (OR) Class A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) G01N 2800/52 (20130101) G01N 2800/304 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197823 | DESLOUCHES |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Berthony DESLOUCHES (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are compositions comprising an antimicrobial cationic amphipathic polypeptide (PAX) and methods of using the same for treatment of a microbial infection |
| FILED | Monday, February 14, 2022 |
| APPL NO | 18/276978 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1729 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197828 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (Manhasset, New York) |
| ASSIGNEE(S) | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (Manhasset, New York) |
| INVENTOR(S) | Ping Wang (Roslyn, New York); Colleen Nofi (Huntington, New York); Monowar Aziz (New Hyde Park, New York); Max Brenner (Briarwood, New York) |
| ABSTRACT | Milk fat globule-epidermal growth factor—factor VIII (MFG-E8) derived oligopeptides and pharmaceutical compositions containing the oligopeptides are provided for treating sepsis and inflammatory conditions. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538023 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1808 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 31/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197830 | Yates-Binder et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Tuskegee University (Tuskegee, Alabama); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The United Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Tuskegee University (Tuskegee, Alabama); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Cecelia C. Yates-Binder (Pittsburgh, Pennsylvania); Jesse Jaynes (Tuskegee, Alabama); Monte S. Willis (Indianapolis, Indiana); Richard J. Bodnar (Pittsburgh, Pennsylvania); Zariel I. Johnson (Pittsburgh, Pennsylvania) |
| ABSTRACT | Interferon-γ-inducible protein 10 (IP-10) peptides, IP-10 peptide variants and in silico designed C-X-C chemokine receptor 3 (CXCR3) peptide agonists are described. The small peptides can be used for inhibiting pathological tissue remodeling and treating fibrosis in a subject, such as a subject with fibrosis of the heart, lung, liver, kidney or skin. The peptide agonists can also be used to treat cardiovascular disease, including myocardial infarction and ischemia-reperfusion injury. Also described are in silico designed peptide antagonists that bind CXCR3 or ligands of CXCR3. These antagonist peptides block CXCR3 signaling by disrupting interaction of CXCR3 with its ligand. Antagonist peptides can be used, for example, to treat myocarditis and atherosclerosis. In additional embodiments agonists and antagonists of CXCR4 are disclosed. |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/419845 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/195 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 35/00 (20180101) Peptides C07K 7/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240197845 — IMMUNOTHERAPY COMPOSITIONS AND METHODS FOR TREATMENT OF TAUOPATHY AND TRANSGENIC MOUSE
| US 20240197845 | Bhaskar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kiran Bhaskar (Albuquerque, New Mexico); Nicole Maphis (Albuquerque, New Mexico); David S. Peabody (Albuquerque, New Mexico); Bryce Chackerian (Albuquerque, New Mexico); Julianne Peabody (Albuquerque, New Mexico); Erin Crossey (Albuquerque, New Mexico) |
| ABSTRACT | This disclosure describes, in one aspect, immunogens effective for treating and/or diagnosing tauopathy, and immunotherapeutic compositions and methods involving those immunogens. Generally, the immunogen includes an antigen presentation component and a microtubule-associated tau protein (MAPT) component linked to at least a portion of the antigen presentation component. This disclosure describes, in another aspect, a transgenic mouse. Generally, the transgenic mouse possesses brain cells that have a polynucleotide that encodes human microtubule-associated protein tau (MAPT). The polynucleotide further exhibits a deletion of at least a portion of endogenous mouse MAPT. The transgenic mouse also includes a forebrain neuron-specific deletion of a polynucleotide that encodes Myeloid Differentiation Primary Response Gene 88 (MyD88). In a further aspect, this disclosure describes a method of producing the transgenic mouse. |
| FILED | Wednesday, January 03, 2024 |
| APPL NO | 18/402899 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2217/15 (20130101) A01K 2217/056 (20130101) A01K 2217/072 (20130101) A01K 2217/075 (20130101) A01K 2227/105 (20130101) A01K 2267/0306 (20130101) A01K 2267/0312 (20130101) A01K 2267/0318 (20130101) A01K 2267/0368 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 39/0007 (20130101) Original (OR) Class A61K 2039/575 (20130101) A61K 2039/5258 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2795/18123 (20130101) C12N 2795/18134 (20130101) C12N 2795/18171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197849 | MURPHY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean C. MURPHY (Seattle, Washington); Bradley C. STONE (Seattle, Washington) |
| ABSTRACT | An immunogenic composition is provided herein. The immunogenic compositions are used to identify and select immunogenic antigens that elicit immune responses in a subject and may be subsequently used in multi-antigen vaccine compositions against one or more diseases or conditions. According to some embodiments, the immunogenic composition may include a plurality of nucleic acid fragments or minigenes derived from a nucleic acid library, wherein each nucleic acid fragment encodes a different antigen or functional portion thereof, and wherein the different antigens or functional portions thereof are associated with one or more disease or condition. The immunogenic composition may also include a delivery medium loaded with the plurality of nucleic acid fragments and in some embodiments, the delivery medium is loaded with nucleic acid fragments in such a way that individual antigen presenting cells receive only a subset of the nucleic acids within a vaccine in order to minimize antigenic competition. |
| FILED | Wednesday, July 26, 2023 |
| APPL NO | 18/359740 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/6921 (20170801) A61K 2039/53 (20130101) A61K 2039/545 (20130101) A61K 2039/5154 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) Peptides C07K 14/15 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197854 | Henderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rory Henderson (Durham, North Carolina); Barton F. Haynes (Durham, North Carolina) |
| ABSTRACT | This invention provides in general, a composition suitable for use in inducing anti-HIV-1 antibodies, such as immunogenic compositions comprising envelope proteins and nucleic acids to induce cross-reactive neutralizing antibodies and increase their breadth of coverage. The invention also provides methods of inducing such broadly neutralizing anti-HIV-1 antibodies using such compositions. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 18/274943 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/575 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197858 | Graham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A as represented by the Secretary, Department of Health and Human Service (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A as represented by the Secretary, Department of Health and Human Service (Bethesda, Maryland) |
| INVENTOR(S) | Barney Graham (Smyrna, Georgia); Rebecca Loomis (Philadelphia, Pennsylvania); Guillaume Stewart-Jones (Cambridge, Massachusetts); John Mascola (Rockville, Maryland) |
| ABSTRACT | Embodiments of immunogens comprising a multimer of NiV G ectodomains and protein nanoparticles comprising an NiV G ectodomain are provided. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/424606 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) Original (OR) Class A61K 2039/70 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197860 | MCGEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Joshua Edward MCGEE (Watertown, Massachusetts); Jack Rainier KIRSCH (Cambridge, Massachusetts); Eric BRESSLER (Boston, Massachusetts); Mark W. GRINSTAFF (Brookline, Massachusetts); Wilson WONG (Brookline, Massachusetts); Lidya Yidnekachew Sertse (Boston, Massachusetts); Kexin Li (Boston, Massachusetts) |
| ABSTRACT | The technology described herein is directed to compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA (saRNA). Also described herein are compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA that is substituted with chemically modified nucleotides. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/512730 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 39/4631 (20230501) A61K 2039/53 (20130101) A61K 2239/23 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Peptides C07K 14/005 (20130101) C07K 14/575 (20130101) C07K 16/32 (20130101) C07K 16/2803 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2770/20022 (20130101) C12N 2770/36143 (20130101) C12N 2830/002 (20130101) C12N 2830/50 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197861 | Buchholz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Ursula J. Buchholz (Silver Spring, Maryland); Shirin Munir (Potomac, Maryland); Cyril Le Nouen (Bethesda, Maryland); Xueqiao Liu (Bethesda, Maryland); Cindy Luongo (Bethesda, Maryland); Peter L. Collins (Silver Spring, Maryland) |
| ABSTRACT | Recombinant chimeric bovine/human parainfluenza virus 3 (rB/HPIV3) vectors expressing a recombinant Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) protein as well as methods of their use and manufacture, are provided. The rB/HPIV3 vector comprises a genome comprising a heterologous gene encoding the recombinant SARS-COV-2 S protein. Nucleic acid molecules comprising the sequence of the genome or antigenome of the disclosed rB/HPIV3 vectors are also provided. The disclosed rB/HPIV3 vectors can be used, for example, to induce an immune response to SARS-COV-2 and HPIV3 in a subject. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 18/555137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/55 (20130101) A61K 2039/543 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 37/04 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2760/18622 (20130101) C12N 2760/18634 (20130101) C12N 2760/18644 (20130101) C12N 2760/18671 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) C12N 2770/20071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197874 | Goronzy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joerg J. Goronzy (Palo Alto, California); Cornelia M. Weyand (Rochester, Minnesota); Jun Jin (Rochester, Minnesota) |
| ABSTRACT | Methods and materials for treating cancer (e.g., melanoma) in a subject and for improving efficacy of adoptive immune cell therapy are described. The methods can include administering immune cells (e.g., chimeric antigen receptor T cells or tumor-infiltrating lymphocytes) having reduced expression of a VPS39 polypeptide to the subject. |
| FILED | Wednesday, June 01, 2022 |
| APPL NO | 18/287909 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/4611 (20230501) A61K 39/4631 (20230501) Original (OR) Class A61K 2239/57 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197876 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaowei XU (Monmouth Junction, New Jersey); Huaishan WANG (Philadelphia, Pennsylvania); Hui CHEN (Beijing, China PRC); Lingling OU (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides methods for selecting donors for γδT cell-based immunotherapy. The disclosure also provides methods for expanding and activating γδ T cells with improved cytotoxicity toward tumor cells and reduced T cell exhaustion. Pharmaceutical compositions comprising the expanded γδ T cells and methods of treatment are also provided. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 18/555214 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/4611 (20230501) A61K 39/4631 (20230501) Original (OR) Class A61K 39/464412 (20230501) A61K 39/464449 (20230501) A61K 2239/31 (20230501) A61K 2239/38 (20230501) A61K 2239/57 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2809 (20130101) C07K 16/2818 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2501/2302 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197886 | Lyons et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York); SingletO2 Therapeutics LLC (New Providence, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan M. Lyons (New Providence, New Jersey); Alexander Greer (New York, New York); QianFeng Xu (Staten Island, New York) |
| ABSTRACT | A device for generating singlet oxygen is provided. The device has a sensitizer that converts triplet oxygen to singlet oxygen upon exposure to light. The device is configured to keep the sensitizer from contacting external fluids. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594359 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0057 (20130101) Original (OR) Class Separation B01D 69/02 (20130101) B01D 71/26 (20130101) B01D 2325/38 (20130101) B01D 2325/0283 (20220801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197904 | Nathanson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Nathanson (Los Angeles, California); Timothy F. Cloughesy (Calabasas, California); Elizabeth Fernandez (Los Angeles, California) |
| ABSTRACT | The present disclosure relates to a method of treating a glioblastoma by conjointly administering to a subject an antibody-drug conjugate comprising a BCL-xL inhibitor and a second therapy such as an alkylating agent, irradiation, or an MCL-1 inhibitor. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 18/288108 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) A61K 31/519 (20130101) A61K 47/6803 (20170801) A61K 47/6849 (20170801) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197914 | Yoon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oklahoma Medical Research Foundation (Oklahoma City, Oklahoma); Hadasit Medical Research Services and Development Ltd. (Jerusalem, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wan Hee Yoon (Edmond, Oklahoma); Tamar Harel (Nevo Beitar, Israel) |
| ABSTRACT | Provided herein are compositions and methods for introducing a genetic change in the genome of a cell with an exogenous DNA template-free Cas-based genome editing system comprising: (i) identifying a target genomic sequence of the genome comprising 88% or higher homology with one or more paralogs or pseudogenes that differ by one or more nucleotides; wherein the homologous region in the one or more paralogs or pseudogenes having a desired nucleotide sequence for transfer to the target genomic sequence after a double-strand break (DSB) by Cas-based genome editing; (ii) introducing into the cell a variant-specific sgRNA to cause a unidirectional transfer of genomic DNA from the homologous DNA sequences to the target genomic sequence, and (iii) contacting the genome of the cell with the variant-specific sgRNA and a Cas-based genome editing system, thereby introducing the genetic conversion without the exogenous DNA template. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390880 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0025 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197919 | Gradinaru et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viviana Gradinaru (Pasadena, California); Xinhong Chen (Pasadena, California) |
| ABSTRACT | Disclosed herein include compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms to the central nervous system with increased specificity and transduction efficiency, including endothelial cells of the neurovascular unit. Also described include methods of treating various diseases and conditions using the rAAVs. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 18/288910 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Original (OR) Class Peptides C07K 14/005 (20130101) C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197928 | SCAFOGLIO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Claudio SCAFOGLIO (LOS ANGELES, California); Steven M. DUBINETT (LOS ANGELES, California) |
| ABSTRACT | Methods, kits, and compositions are described for the detection and treatment of premalignant lesions. This early detection allows patients to avoid the risks associated with repetitive imaging often employed to seek differentiation between developing cancer and inflammation. The method comprises (a) administering to the subject a radiographic tracer for a sodium/glucose cotransporter (SGLT): (b) performing a radiographic detection scan of the subject; and (c) detecting signal emitted by the tracer taken up in the scanned subject, whereby detected signal in the subject is indicative of a pre-malignant lesion. In some embodiments, the method further comprises administering an inhibitor of sodium-glucose transporter 2 (SGLT2), such as gliflozin, to a subject in whom a pre-malignant lesion has been detected. In some embodiments, the pre-malignant lesion is in tissue that expresses SGLT2, such as a lung, prostate, bladder, breast, or pancreatic lesion. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/755429 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7034 (20130101) A61K 31/7042 (20130101) A61K 31/7048 (20130101) A61K 51/0491 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198080 | WU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zhongjun WU (Marriottsville, Maryland); Bartley P. GRIFFITH (Gibson Island, Maryland); Jiafeng ZHANG (Silver Spring, Maryland); Charles Luddy (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongjun WU (Marriottsville, Maryland); Bartley P. GRIFFITH (Gibson Island, Maryland); Jiafeng ZHANG (Silver Spring, Maryland); Charles Luddy (Alexandria, Virginia) |
| ABSTRACT | A blood flow pump device includes a centrifugal pump having a single ball-and-cup hybrid magnetic/blood immersed bearing-supported shrouded impeller driven by a magnetically coupled motor drive. The device further includes a housing, an impeller, and a shroud, thus forming a pump chamber. The impeller is a shrouded impeller having extended blades from a hub of the impeller and the shroud. The system and method employ a blood flow pump device having a housing with a blood inlet and a blood outlet, the housing defining a fluid pathway between the inlet and the outlet, and the housing containing an impeller comprising a base, a base lid, two blades, and a shroud, with the housing positioned on a motor. A controller communicates with the motor and controls rotational speed of the impeller in response to the blood flow through the blood outlet. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 18/554585 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/109 (20210101) A61M 60/232 (20210101) Original (OR) Class A61M 60/419 (20210101) A61M 60/422 (20210101) A61M 60/538 (20210101) A61M 60/825 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198127 | KURENOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Health Research, Inc. (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergei KURENOV (West Falls, New York); Gal SHAFIRSTEIN (Amherst, New York); Nathaniel IVANICK (Clarence, New York); David BELLNIER (Buffalo, New York); Lawrence TWOREK (West Seneca, New York) |
| ABSTRACT | A device includes a first fiber lock configured to be attached to a handle of an EUS-NA device and to selectively lock or unlock a fiber optic cable in position with respect to a sample needle. A second fiber lock is configured to be attached to abase of the EUS-NA device and to selectively lock or unlock a fiber optic cable in position. A method includes passing a fiber optic cable through a passage of the EUS-NA device such that an end of the fiber optic cable is at a tip of a sample needle of the EUS-NA device. The fiber optic cable is locked relative to the sample needle, and the sample need is advanced into the target tissue. The fiber optic cable is unlocked from the sample needle and locked relative to abase of the EUS-NA device. The sample needle is retracted such that the end of the fiber optic cable remains in the target tissue. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 18/557950 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 2005/063 (20130101) A61N 2005/0626 (20130101) A61N 2005/0632 (20130101) A61N 2005/0659 (20130101) A61N 2005/0663 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198128 | Jenkins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boston Scientific Neuromodulation Corporation (Valencia, California); Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Jenkins (Beachwood, Ohio); Junqi Zhuo (Cleveland Heights, Ohio); Michael A. Moffitt (Solon, Ohio); Joshua Dale Howard (Sacramento, California); Changfang Zhu (Valencia, California) |
| ABSTRACT | An optical lead can include a cuff body having an exterior surface and an interior surface, wherein the cuff body defines a nerve channel for receiving a portion of a nerve; a lead body coupled, or coupleable, to the cuff body; at least one light emitter disposed on or within the cuff body or the lead body; and at least one reflective element disposed on, within, or beneath the interior surface of the cuff body, wherein the at least one reflective element is configured to reflect light emitted from the at least one light emitter. Alternatively or additionally, the cuff lead can include a receptacle for removably receiving a distal end portion of the lead body. Another system includes a cuff body with at least one light emitter, an electronic subassembly for operation, and an antenna to receive power from an external source. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/381109 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0556 (20130101) A61N 5/0601 (20130101) A61N 5/0622 (20130101) Original (OR) Class A61N 2005/065 (20130101) A61N 2005/0665 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198136 | LARKIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RefleXion Medical, Inc. (Hayward, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David LARKIN (Menlo Park, California); William KNAPP (EI Granada, California); Eugene DUVAL (Menlo Park, California); Layton HALE (Castro Valley, California); David MEER (Sonora, California); Matthew DIGGS (Farmington, Michigan) |
| ABSTRACT | Described herein are multi-leaf collimators that comprise leaf drive mechanisms. The leaf drive mechanisms can be used in binary multi-leaf collimators used in emission-guided radiation therapy. One variation of a multi-leaf collimator comprises a pneumatics-based leaf drive mechanism. Another variation of a multi-leaf collimator comprises a spring-based leaf drive mechanism having a spring resonator. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/490732 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1045 (20130101) Original (OR) Class A61N 2005/1074 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198256 | IVANOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander IVANOV (Newton, Massachusetts); Alan Zimmerman (Boston, Massachusetts) |
| ABSTRACT | The present technology provides straightforward, reproducible, scalable, and efficient multimode chromatography-based methods for the effective isolation and/or purification of nanoparticulate biomaterials from mixtures of biomaterials. The methods can be used to isolate and purify extracellular vesicles and other nanoparticulate biomaterials from plasma and other sources to provide high purity products. The methods can be used to diagnose medical conditions and to prepare pharmaceutical products. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/540481 |
| CURRENT CPC | Separation B01D 15/3847 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198337 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weiqiang Chen (New York, New York); Chao Ma (New York, New York) |
| ABSTRACT | The present invention provides devices that replicate bone marrow niche in a microfluidic chip. The devices can be used to model certain disease states related to bone marrow, such as leukemic bone marrow niche remission and relapse under various treatment conditions. The devices can be adapted to replicate bone marrow niche from patient-specific cells such that treatment conditions can be modeled and tailored to individual patients. In some embodiments, the devices are suitable for evaluating leukemia therapies on a patient-specific basis. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/555363 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/16 (20130101) B01L 2300/0816 (20130101) B01L 2400/086 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198338 | Kapur et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravi Kapur (Sharon, Massachusetts); Kyle C. Smith (Cambridge, Massachusetts); Mehmet Toner (Charlestown, Massachusetts) |
| ABSTRACT | A microfluidic device includes a particle sorting region having a first, second and third microfluidic channels, a first array of islands separating the first microfluidic channel from the second microfluidic channel, and a second array of islands separating the first microfluidic channel from the third microfluidic channel, in which the island arrays and the microfluidic channels are arranged so that a first fluid is extracted from the first microfluidic channel into the second microfluidic channel and a second fluid is extracted from the third microfluidic channel into the first microfluidic channel, and so that particles are transferred from the first fluid sample into the second fluid sample within the first microfluidic channel. |
| FILED | Tuesday, March 05, 2024 |
| APPL NO | 18/595920 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 3/502776 (20130101) B01L 2200/12 (20130101) B01L 2200/0631 (20130101) B01L 2200/0647 (20130101) B01L 2200/0652 (20130101) B01L 2200/0668 (20130101) B01L 2200/0684 (20130101) B01L 2300/185 (20130101) B01L 2300/0681 (20130101) B01L 2300/0877 (20130101) B01L 2400/043 (20130101) B01L 2400/082 (20130101) B01L 2400/0409 (20130101) B01L 2400/0415 (20130101) B01L 2400/0436 (20130101) B01L 2400/0457 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4077 (20130101) G01N 15/01 (20240101) G01N 15/149 (20240101) G01N 15/0255 (20130101) G01N 15/0618 (20130101) G01N 15/1484 (20130101) G01N 2001/4088 (20130101) G01N 2015/0053 (20130101) G01N 2015/0288 (20130101) G01N 2015/1486 (20130101) G01N 2015/1493 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198339 | Kapur et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravi Kapur (Sharon, Massachusetts); Kyle C. Smith (Cambridge, Massachusetts); Mehmet Toner (Charlestown, Massachusetts) |
| ABSTRACT | A microfluidic device includes: a first microfluidic channel; a second microfluidic channel extending along the first microfluidic channel; and a first array of islands separating the first microfluidic channel from the second microfluidic channel, in which each island is separated from an adjacent island in the array by an opening that fluidly couples the first microfluidic channel to the second microfluidic channel, in which the first microfluidic channel, the second microfluidic channel, and the islands are arranged so that a fluidic resistance of the first microfluidic channel increases relative to a fluidic resistance of the second microfluidic channel along a longitudinal direction of the first microfluidic channel such that, during use of the microfluidic device, a portion of a fluid sample flowing through the first microfluidic channel passes through one or more of the openings between adjacent islands into the second microfluidic channel. |
| FILED | Tuesday, March 05, 2024 |
| APPL NO | 18/595927 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 3/502776 (20130101) B01L 2200/12 (20130101) B01L 2200/0631 (20130101) B01L 2200/0647 (20130101) B01L 2200/0652 (20130101) B01L 2200/0668 (20130101) B01L 2200/0684 (20130101) B01L 2300/185 (20130101) B01L 2300/0681 (20130101) B01L 2300/0877 (20130101) B01L 2400/043 (20130101) B01L 2400/082 (20130101) B01L 2400/0409 (20130101) B01L 2400/0415 (20130101) B01L 2400/0436 (20130101) B01L 2400/0457 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4077 (20130101) G01N 15/01 (20240101) G01N 15/149 (20240101) G01N 15/0255 (20130101) G01N 15/0618 (20130101) G01N 15/1484 (20130101) G01N 2001/4088 (20130101) G01N 2015/0053 (20130101) G01N 2015/0288 (20130101) G01N 2015/1486 (20130101) G01N 2015/1493 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199525 | Agazie |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yehenew Agazie (Morgantown, West Virginia) |
| ABSTRACT | The present invention provides a compound of the formula: wherein R1 is a hydrogen or a COOH, R2 is a hydrogen or a COOH, R3 is a hydrogen or a COOH, R4 is one selected from the group consisting of H, COOH, and CH2COOH, and R5 is one selected from the group consisting of H, COOH, and CH2COOH. The present invention provides a compound having the formula: wherein R is COOH or CH2COOH. Pharmaceutical compositions comprising one of these compounds and at least one of an acceptable pharmaceutical carrier, are provided. Methods of treating a patient having cancer are provided. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511496 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 59/64 (20130101) C07C 65/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199572 | THATCHER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Chcago, Illinois); ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory R. THATCHER (Tucson, Arizona); Cutler T. LEWANDOWSKI (Chicago, Illinois); Manel BEN AISSA (Chicago, Illinois); Brian LAYDEN (La Grange Park, Illinois); Yeng-Jeng SHAW (Tucson, Arizona); Ganga Reddy VELMA (Tucson, Arizona); Mary Jo LADU (, None) |
| ABSTRACT | Compounds that induce expression of ATP-binding cassette transporter A1 (ABCA1) without lipogenesis are provided, as are methods of using the same to treat or prevent type 2 diabetes or dementia. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 18/280531 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) A61K 31/69 (20130101) A61K 31/381 (20130101) A61K 31/397 (20130101) A61K 31/428 (20130101) A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/4025 (20130101) A61K 31/4245 (20130101) A61K 31/4436 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 333/40 (20130101) Original (OR) Class C07D 409/12 (20130101) C07D 413/04 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199591 | THAKUR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts); Indiana University Research and Technology Corporation (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ganeshsingh A. THAKUR (Cambridge, Massachusetts); Diomedes E. LOGOTHETIS (Brookline, Massachusetts); Lucas CANTWELL (Plymouth, Massachusetts); Yu XU (Malden, Massachusetts); Anantha SHEKHAR (Indianapolis, Indiana) |
| ABSTRACT | Selective small molecule regulators of GIRK potassium channels are provided, which are effective in treatment of post-traumatic stress disorder and other medical conditions. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392203 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/22 (20180101) Heterocyclic Compounds C07D 231/40 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 409/12 (20130101) Original (OR) Class C07D 413/12 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199604 | Prusiner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Stanley B. Prusiner (San Francisco, California); Nick A. Paras (San Francisco, California); Jay Conrad (San Francisco, California); Ny Sin (San Francisco, California); Sandeep Raikar (San Francisco, California); Mark Vander Wal (San Francisco, California); Jean-Marc M. Grandjean (San Francisco, California); Shigeo Yamanoi (San Francisco, California); Masahiro Inoue (San Francisco, California); Shimpei Hirano (San Francisco, California); Masatoshi Honzumi (San Francisco, California); Koji Sasaki (San Francisco, California); Yamato Suzuki (San Francisco, California); Atsushi Tengeiji (San Francisco, California); Daniel R. Southworth (San Francisco, California); Darren Hutt (San Francisco, California); Jacob I. Ayers (San Francisco, California); Steven H. Olson (San Francisco, California); Cuong Quoc Ly (San Francisco, California); John West (San Francisco, California); Gregory E. Merz (San Francisco, California); Helene Viart (San Francisco, California); Osamu Iwamoto (San Francisco, California) |
| ABSTRACT | The invention provides compounds, and methods of using those compounds to treat neurodegenerative diseases. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468633 |
| CURRENT CPC | Heterocyclic Compounds C07D 413/04 (20130101) C07D 413/14 (20130101) C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 491/048 (20130101) C07D 495/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199636 | Mazin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander V. Mazin (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention includes novel RAD52 inhibitors for preventing or treating cancers in a subject in need thereof. The present invention further includes a method of preventing or treating cancers in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In certain embodiments, the subject is further administered at least one additional therapeutic agent. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482143 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/55 (20130101) A61K 31/496 (20130101) A61K 31/517 (20130101) A61K 31/4188 (20130101) A61K 31/4525 (20130101) A61K 31/4741 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 215/38 (20130101) C07D 239/95 (20130101) C07D 307/82 (20130101) C07D 405/12 (20130101) C07D 471/04 (20130101) C07D 491/048 (20130101) C07D 491/056 (20130101) C07D 495/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199664 | Mirica et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); The Regents of the University of California (Oalkland, California) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire); The Regents of The University Of California (Oakland, California) |
| INVENTOR(S) | Katherine A. Mirica (Hanover, New Hampshire); Aylin Aykanat (Lyme, New Hampshire); Evan Cline (Lebanon, New Hampshire); Zheng Meng (West Lebanon, New Hampshire); Christopher G. Jones (Los Angeles, Canada); Hosea Nelson (Venice, California) |
| ABSTRACT | Embodiments of the present disclosure pertain to compositions that include a metal-organic framework. The metal-organic framework includes a plurality of metals and a plurality of ligands coordinated with the plurality of metals, where the plurality of metals include bismuth, and the plurality of ligands include a plurality of hydroxy moieties that are not part of carboxyl groups. At least some of the hydroxy moieties are coordinated with bismuth to form Bi—O bonds. The metal-organic framework is in the form of a conductive and interconnected network. Additional embodiments of the present disclosure pertain to methods of utilizing the compositions to detect analytes in a sample and shield various objects from radiation. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 18/286796 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/107 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/94 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 31/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199675 | Boons et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geert-Jan Boons (Athens, Georgia); Anthony Robert Prudden (Athens, Georgia); Lin Liu (Athens, Georgia) |
| ABSTRACT | Disclosed herein are oligosaccharides and intermediates useful for the production thereof. The compounds are useful as analytical standards and as intermediates for the preparation of more complex oligosaccharide and N-glycan products. The compounds may be prepared in high purity using the selective stop/go synthetic methods disclosed herein. |
| FILED | Thursday, August 31, 2023 |
| APPL NO | 18/240621 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 5/06 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/26 (20130101) C12P 19/305 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199677 | Clemons et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); UNIVERSITY OF TENNESSEE FRESEARCH FOUNDATION (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William M. Clemons (Colliervielle, California); Michio Kurosu (Memphis, Tennessee) |
| ABSTRACT | The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein. |
| FILED | Wednesday, February 01, 2023 |
| APPL NO | 18/104297 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 19/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199683 | MICALIZIO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Glenn C. MICALIZIO (Norwich, Vermont) |
| ABSTRACT | The present disclosure relates to polycyclic (e.g., tetracyclic) androgen receptor (AR) modulators, synthetic methods for preparing such AR modulators, and methods of using such AR modulators to treat an androgen-dependent condition, such as prostate cancer or BPH. Exemplary compounds have quaternary centers at C10 and C13 and a fused cyclic ring comprising C14 and C15. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 18/550624 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/568 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Steroids C07J 53/008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199687 | HONDAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert J. HONDAL (Burlington, Vermont); Kaelyn JENNY (Essex Junction, Vermont) |
| ABSTRACT | Presented is a method to incorporate 2-thiohistidine (2-thioHis) into a peptide. Also provided are peptides incorporating 2-thioHis, compositions, and methods of using the peptides incorporating 2-thioHis. The methods may be methods for scavenging metals and/or radicals or reducing oxidative stress. 2-thioHis has the following structure: |
| FILED | Friday, April 22, 2022 |
| APPL NO | 18/556587 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/64 (20130101) A61K 38/00 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/00 (20130101) Peptides C07K 1/14 (20130101) C07K 1/042 (20130101) C07K 1/063 (20130101) C07K 1/1075 (20130101) Original (OR) Class C07K 1/1077 (20130101) C07K 5/0815 (20130101) C07K 5/06086 (20130101) C07K 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199698 | JUN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UAB RESEARCH FOUNDATION (Birmingham, Alabama); Endomimetics LLC (BIRMINGHAM, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HO-WOOK JUN (Birmingham, Alabama); BRIGITTA BROTT (Birmingham, Alabama); XIXI ZHANG (Birmingham, Alabama); JUN CHEN (Birmingham, Alabama); JENNIFER SHERWOOD (Birmingham, Alabama); PATRICK HWANG (Birmingham, Alabama) |
| ABSTRACT | Disclosed are peptide amphiphiles comprising a hydrophilic peptide sequence and a hydrophobic tail, wherein the hydrophobic tail comprises a moiety having a substituted C5 alkyl chain, wherein the hydrophilic peptide sequence comprises a nitric oxide producing donor sequence. In some aspects, the hydrophilic peptide sequence comprises a degrading sequence (DS), wherein the degrading sequence (DS) comprises the amino acid sequence GTAGLIGQ (SEQ ID NO:1) wherein the DS comprises one or more amino acid substitutions. Also disclosed are compositions, liposomes, gels, and medical devices comprising the peptide amphiphiles and methods of use thereof. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482740 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 31/7036 (20130101) A61K 38/14 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 29/00 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199705 | GARCIA-SASTRE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| INVENTOR(S) | Adolfo GARCIA-SASTRE (New York, New York); Ignacio MENA (New York, New York); Peter PALESE (New York, New York); Florian KRAMMER (New York, New York); Weina SUN (New York, New York) |
| ABSTRACT | In one aspect, described herein are recombinant Newcastle disease virus (“NDV”) comprising a packaged genome, wherein the packaged genome comprises a nucleotide sequence of a Newcastle disease virus genome in which the nucleotide sequence encoding the NDV HN protein has been replaced with a nucleotide sequence encoding the HN protein of an avian paramyxovirus (APMV) other than NDV or a variant of the non-NDV-APMV HN protein, and the nucleotide sequence encoding the NDV F protein has been replaced with a nucleotide sequence encoding the F protein of an APMV other than NDV or a variant of the non-NDV-APMV F protein. In some embodiments, the packaged genome further comprises a transgene comprising a nucleotide sequence encoding an antigen. Also described herein are compositions comprising such recombinant NDV and the use of such recombinant NDV to induce an immune response in a subject. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 18/556458 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/17 (20130101) A61K 2039/525 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2760/18122 (20130101) C12N 2760/18134 (20130101) C12N 2760/18143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199735 | WONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Methodist Hospital (Houston, Texas); Board of Regents, The University of Texas System (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen T.C. WONG (Missouri City, Texas); Jianting SHENG (Pearland, Texas); Samuel C. MOK (Sugar Land, Texas); Cecilia S. LEUNG (Missouri City, Texas); Tsz-Lun YEUNG (Houston, Texas) |
| ABSTRACT | Disclosed are antibody compositions and methods for treatment mammalian cancers. Also disclosed are methods for use of the disclosed MFAP5-specific monoclonal antibodies and antigen-binding-fragments thereof, in the treatment, prophylaxis, and/or the amelioration of one or more symptoms of mammalian cancer, including human ovarian and pancreatic cancers, in particular. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 16/936421 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/28 (20130101) Original (OR) Class C07K 2317/56 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) G01N 33/582 (20130101) G01N 33/57449 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199757 | KOSSIAKOFF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| INVENTOR(S) | Anthony KOSSIAKOFF (Chicago, Illinois); Carla E. MEINTS (Chicago, Illinois); Somnath MUKHERJEE (Chicago, Illinois) |
| ABSTRACT | Aspects of the present disclosure are directed to NT5E (CD73)-targeting polypeptides, including antibodies, antibody-drug conjugates, antibody fragments, antibody-like molecules, and chimeric receptors. Also disclosed herein are nucleic acids encoding for such NT5E-targeting polypeptides and cells comprising such nucleic acids. Described are methods for treatment of cancer using NT5E-targeting polypeptides. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/590875 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199794 | Song et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Song (Shrewsbury, Massachusetts); Jing Zhang (Guangzhou, China PRC) |
| ABSTRACT | The invention provides novel compounds and polymers with pendant aspirin, and degradable and biocompatible compositions, medical devices and implants, and methods of making and use thereof. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 18/553600 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 2300/41 (20130101) A61L 2400/16 (20130101) Heterocyclic Compounds C07D 319/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) Original (OR) Class C08G 2230/00 (20130101) C08G 2280/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200029 | ZHANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (HANOVER, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tong ZHANG (Lebanon, New Hampshire); Charles L. SENTMAN (Grantham, New Hampshire) |
| ABSTRACT | The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using these chimeric NKp30 T cells to address diseases and disorders. In one aspect, the disclosure broadly relates to chimeric NKp30 T cells, isolated populations thereof, and compositions comprising the same. In another aspect, said chimeric NKp30 T cells are further designed to express a functional non-TCR receptor. The disclosure also pertains to methods of making said chimeric NKp30 T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said chimeric NKp30 T cells, populations thereof, or compositions comprising the same. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/513960 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Peptides C07K 14/70503 (20130101) C07K 14/70521 (20130101) C07K 14/70575 (20130101) C07K 14/70578 (20130101) C07K 14/70596 (20130101) C07K 16/2803 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/00 (20130101) C12N 15/62 (20130101) C12N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200031 | Hsu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katharine C Hsu (New York, New York); Mohammed Kazim Panjwani (New York, New York) |
| ABSTRACT | In some aspects, the present invention involves chimeric recombinant HLA proteins that are derived from HLA-E proteins and comprise a leader peptide from an HLA-A, HLA-B, HLA-C or HLA-G protein. In some aspects, the present invention also involves nucleic acid molecules encoding such recombinant HLA proteins, vectors comprising such nucleic acid molecules, host cells comprising such recombinant HLA proteins, and various related compositions. In some aspects, the present invention also involves methods of use of such recombinant HLA proteins, nucleic acid molecules, vectors, host cells and compositions. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 18/555079 |
| CURRENT CPC | Peptides C07K 14/70539 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 5/0646 (20130101) C12N 15/86 (20130101) C12N 2501/2302 (20130101) C12N 2502/99 (20130101) C12N 2510/00 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200036 | Wells et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James M. Wells (Cincinnati, Ohio); Carey Lane Watson (Cincinnati, Ohio); Jorge Orlando Munera (Cincinnati, Ohio); Maxime Mickael Mahe (Cincinnati, Ohio); Michael A. Helmrath (Cincinnati, Ohio); Michael J. Workman (Santa Monica, California) |
| ABSTRACT | Disclosed are methods for making a vascularized hollow organ derived from human intestinal organoid (HIOs). The HIOs may be obtained from human embryonic stem cells (ESC's) and/or induced pluripotent stem cells (iPSCs), such that the HIO forms mature intestinal tissue. Also disclosed are methods for making a human intestinal tissue containing a functional enteric nervous system (ENS). |
| FILED | Friday, March 08, 2024 |
| APPL NO | 18/156726 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) A01K 2227/30 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0679 (20130101) Original (OR) Class C12N 5/0697 (20130101) C12N 2501/10 (20130101) C12N 2501/11 (20130101) C12N 2501/16 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/345 (20130101) C12N 2501/385 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2502/08 (20130101) C12N 2502/23 (20130101) C12N 2503/00 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200050 | VAN DEVENTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts) |
| INVENTOR(S) | James A. VAN DEVENTER (Medford, Massachusetts); Jessica T. STIEGLITZ (Medford, Massachusetts) |
| ABSTRACT | The invention provides aminoacyl-tRNA synthetases, compositions thereof, and methods for use thereof. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/513092 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/66 (20130101) Enzymes C12Y 601/01001 (20130101) C12Y 601/01004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200134 | Love et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | J. Christopher Love (Somerville, Massachusetts); Todd Michael Gierahn (Brookline, Massachusetts); Alexander K. Shalek (Lexington, Massachusetts); Marc Havens Wadsworth (Somerville, Massachusetts); Travis K. Hughes (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure describes improvements to both hardware and enzymatic reactions used in single cell analyses such as but not limited to Seq-well that enable significant increases in the yield of transcripts per cell, improved portability and case of use, increased scalability of the assay, and linkage of transcript information to other measurements made in the picowell arrays. |
| FILED | Thursday, August 10, 2023 |
| APPL NO | 18/448121 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 2200/0647 (20130101) B01L 2300/0681 (20130101) B01L 2300/0819 (20130101) B01L 2300/0829 (20130101) B01L 2300/0851 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1068 (20130101) C12N 15/1093 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) Original (OR) Class Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/2014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200141 | Tseng et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Hsian-Rong Tseng (Los Angeles, California); Yazhen Zhu (Los Angeles, California); Na Sun (Los Angeles, California); Vatche G Agopian (Woodland Hills, California) |
| ABSTRACT | Methods for selectively capturing an extracellular vesicle (EV) from a sample. including the steps of: functionalizing a capture agent for the EV with a first molecule from a first bioorthogonal functional group such that the capture agent remains attachable to the EV and the first molecule is also able to bond to a second molecule from a second bioorthogonal functional group. the second molecule being complementary to the first molecule: mixing the functionalized capture agent with the sample such that the functionalized capture agent binds to the EV and such that an activated sample is formed: functionalizing a capture surface with the second molecule: and depositing at least a portion of the activated sample on at least a portion of the functionalized capture surface to thereby selectively capture the EV by binding of the second molecule with the first molecule. |
| FILED | Saturday, March 06, 2021 |
| APPL NO | 17/915071 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6844 (20130101) C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200147 | Guo |
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| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy Lan Guo (Morgantown, West Virginia) |
| ABSTRACT | This invention provides a method of treating a patient having non-small cell lung cancer comprising administering to said patient a therapeutically effective amount of a compound selected from the group consisting of PD-198306 or pharmaceutically acceptable salts thereof, U-0126 or pharmaceutically acceptable salts thereof, ZM-306416 or pharmaceutically acceptable salts thereof, and PQ-401 or pharmaceutically acceptable salts thereof, for treating non-small cell lung cancer in said patient. This invention provides a method for producing an immune response in a patient having non-small cell lung cancer comprising administering to said patient a therapeutically effective amount of a compound selected from the group consisting of PD-198306, U-0126, ZM-306416, and PQ-401, for producing an immune response in said patient. |
| FILED | Wednesday, November 22, 2023 |
| APPL NO | 18/517623 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/166 (20130101) A61K 31/277 (20130101) A61K 31/517 (20130101) A61K 31/4706 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201089 | Hariri et al. |
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| FUNDED BY |
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| APPLICANT(S) | CZ Biohub SF, LLC (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanfored, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amani Hariri (Stanford, California); Constantin Dory (Stanford, California); Alyssa Cartwright (Stanford, California); Jelena Vuckovic (Palo Alto, California); Hyongsok Tom Soh (Palo Alto, California) |
| ABSTRACT | The disclosure provides an optical probe comprising an optical waveguide attached to a molecular switch that produces an altered optical signal upon binding a target molecule. The disclosure also provides an optical sensor system comprising an optical probe, a light source configured to emit the excitation light to be coupled into the optical waveguide of the optical probe; and a detector. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/589897 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/1455 (20130101) A61B 5/6801 (20130101) A61B 5/6846 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/648 (20130101) G01N 21/6486 (20130101) Original (OR) Class G01N 2021/6441 (20130101) G01N 2021/6484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201134 | Gundlach et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jens H. Gundlach (Seattle, Washington); Ian M. Derrington (Seattle, Washington); Marcus D. Collins (Issaquah, Washington) |
| ABSTRACT | Provided herein are methods and systems pertaining to sequencing units of analytes using nanopores. In general, arresting constructs are used to modify an analyte such that the modified analyte pauses in the opening of a nanopore. During such a pause, an ion current level is obtained that corresponds to a unit of the analyte. After altering the modified analyte such that the modified analyte advances through the opening, another arresting construct again pauses the analyte, allowing for a second ion current level to be obtained that represents a second unit of the analyte. This process may be repeated until each unit of the analyte is sequenced. Systems for performing such methods are also disclosed. |
| FILED | Thursday, January 18, 2024 |
| APPL NO | 18/416797 |
| CURRENT CPC | Separation B01D 2325/02 (20130101) B01D 2325/24 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 15/00 (20130101) Peptides C07K 14/35 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/447 (20130101) G01N 27/44704 (20130101) G01N 27/44726 (20130101) G01N 27/44747 (20130101) G01N 27/44786 (20130101) G01N 27/44791 (20130101) Original (OR) Class G01N 33/48721 (20130101) Electric Digital Data Processing G06F 1/206 (20130101) G06F 3/061 (20130101) G06F 3/0604 (20130101) G06F 3/0614 (20130101) G06F 3/0616 (20130101) G06F 3/0625 (20130101) G06F 3/0629 (20130101) G06F 3/0647 (20130101) G06F 3/0653 (20130101) G06F 3/0659 (20130101) G06F 3/0673 (20130101) G06F 3/0679 (20130101) G06F 12/0238 (20130101) G06F 12/0246 (20130101) G06F 2212/1016 (20130101) G06F 2212/7206 (20130101) Static Stores G11C 7/04 (20130101) Climate Change Mitigation Technologies in Information and Communication Technologies [ICT] i.e Information and Communication Technologies Aiming at the Reduction of Their Own Energy Use Y02D 10/00 (20180101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/712 (20130101) Y10S 977/714 (20130101) Y10S 977/781 (20130101) Y10S 977/924 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201190 | IVRY et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Sam L. IVRY (San Francisco, California); Anthony J. O'DONOGHUE (La Jolla, California); Kimberly KIRKWOOD (San Francisco, California); Charles S. CRAIK (San Francisco, California) |
| ABSTRACT | The present disclosure relates generally to detection of molecular biomarkers in a sample or diagnosis of a subject based upon detection or quantification of molecular biomarkers in a sample, specifically to the identification and use of biomarkers for pancreatic cysts. |
| FILED | Tuesday, July 11, 2023 |
| APPL NO | 18/350009 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/57438 (20130101) Original (OR) Class G01N 2333/96416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201197 | IVANOV et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander IVANOV (Newton, Massachusetts); Anne-Lise MARIE (Brighton, Massachusetts); Yunfan GAO (Somerville, Massachusetts) |
| ABSTRACT | An integrated platform is provided for direct and unbiased label-free native analysis of N-glycans from single cells and biological samples as small as 1 nL or less. An in-capillary sample processing method is coupled with high-sensitivity label-free capillary electrophoresis and mass spectrometry. Direct, label-free characterization and quantification of single-cell surface N-glycomes can be performed with the detection of up to 100 N-glycans per single cell and up to 400 N-glycans per nL of blood. N-glycome alterations can be detected at the single-cell level for diagnosis of medical conditions. The platform also preserves cell integrity and therefore can be used for spatial glycomic and multiomic profiling at the single cell level. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/542532 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44743 (20130101) G01N 27/44791 (20130101) G01N 33/68 (20130101) Original (OR) Class G01N 2333/98 (20130101) G01N 2400/10 (20130101) G01N 2560/00 (20130101) G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201198 | MARCOTTE et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); ERISYON, INC. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward MARCOTTE (Austin, Texas); Eric V. ANSLYN (Austin, Texas); Jagannath SWAMINATHAN (Austin, Texas); Cecil J. HOWARD, II (Austin, Texas); Angela M. BARDO (Austin, Texas); Zachary Booth SIMPSON (Austin, Texas) |
| ABSTRACT | The present disclosure provides a range of methods for dense information storage in oligomeric constructs, such as peptides. Various methods of the present disclosure provide for information storage in oligomers and oligomer libraries, and information retrieval by subsequent oligomer sequencing or analysis. The present disclosure further provides methods for appending information to materials and molecules with analyzable oligomeric constructs. |
| FILED | Friday, November 24, 2023 |
| APPL NO | 18/518854 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6821 (20130101) G01N 33/6824 (20130101) Original (OR) Class G01N 33/6848 (20130101) G01N 2333/9015 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201199 | Havranek et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | James J. Havranek (Clayton, Missouri); Benjamin Borgo (St. Louis, Missouri) |
| ABSTRACT | Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the N-terminal amino acid or N-terminal phosphorylated amino acid of a polypeptide. Also, an enzyme for use in the cleavage step of the Edman degradation reaction and a method for using this enzyme are described. |
| FILED | Thursday, November 30, 2023 |
| APPL NO | 18/524884 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) C12N 9/93 (20130101) C12N 9/485 (20130101) C12N 9/641 (20130101) Enzymes C12Y 304/11018 (20130101) C12Y 601/0101 (20130101) C12Y 601/0102 (20130101) C12Y 601/01021 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6824 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201200 | Slavov et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts); Scienion GmbH (Berlin, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolai Slavov (Cambridge, Massachusetts); Andrew Leduc (Hingham, Massachusetts); Richard Huffman (Boston, Massachusetts); Aileen Murphy (Madison, Wisconsin); Joshua Cantlon-Bruce (Phoenix, Arizona) |
| ABSTRACT | The disclosure provides methods of forming one or more single-cell proteomic samples, such as by: dispensing n droplets of lysis buffer onto a substantially planar solid surface, wherein n>2: dispensing a single cell into each of the n droplets of lysis buffer to produce n droplets with a lysed single cell: dispensing digestion buffer into each of the n droplets to digest proteins from each lysed single cell to produce n droplets comprising peptides: dispensing a chemical tag into at least a subset of the n droplets comprising the peptides to produce labeled peptides, thereby enabling the labeled peptides in a given droplet to be distinguishable from labeled peptides in at least one other droplet: and applying a fluid to merge at least a subset of the droplets into a combined droplet on the substantially planar surface, thereby combining the labeled peptides to form a single-cell proteomic sample. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 18/556655 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/34 (20130101) G01N 33/6827 (20130101) Original (OR) Class G01N 33/6848 (20130101) G01N 2333/976 (20130101) G01N 2458/15 (20130101) G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201203 | Petrov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dmitri A. Petrov (San Francisco, California); Monte M. Winslow (Stanford, California); Gabor Boross (Redwood City, California); Maryam Yousefi (Redwood City, California) |
| ABSTRACT | Methods and compositions are provided for treating individuals who have an oncogene-negative cancer. In some cases, such individuals have an oncogene-negative tumor(s). In some cases, they have an oncogene-negative lung cancer. In some cases, they have an oncogene-negative lung adenocarcinoma. In some cases, treatment includes administering an inhibitor of the Ras/MAPK pathway. In some cases, treatment includes administering an inhibitor of the Ras/MAPK pathway and an inhibitor of the PI3K-AKT pathway. Methods and compositions are also provided for testing candidate cancer therapeutics. In some cases, such methods include contacting an oncogene-negative cell, in culture or in vivo, with a candidate agent, where the cell has increased Ras/MAPK pathway activity and/or increased PI3K-AKT pathway activity. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 18/288372 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2227/105 (20130101) A01K 2267/0331 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/501 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/5044 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/912 (20130101) G01N 2800/52 (20130101) G01N 2800/7057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201204 | Pieper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University Hospitals Cleveland Medical Center (Cleveland, Ohio) |
| ASSIGNEE(S) | University Hospitals Cleveland Medical Center (Cleveland, Ohio) |
| INVENTOR(S) | Andrew A. Pieper (Cleveland, Ohio); Min-Kyoo Shin (Cleveland, Ohio); Edwin Vazquez-Rosa (Cleveland, Ohio) |
| ABSTRACT | In one aspect, disclosed herein is a method of diagnosing and/or prognosing a neurodegenerative disease in a subject, the method comprising: obtaining a plasma or blood sample from a subject; and detecting a level of acetylated Tau in the plasma or blood sample, wherein a level of acetylated Tau that is at least 25% or 50% higher than a control level in a healthy subject indicates that the subject has a neurodegenerative disease such as traumatic brain injury. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/790480 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/335 (20130101) A61K 31/403 (20130101) A61K 31/603 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/4709 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201205 | Prusiner et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Stanley B. Prusiner (San Francisco, California); Nick A. Paras (San Francisco, California); Jay Conrad (San Francisco, California); Ny Sin (San Francisco, California); Sandeep Raikar (San Francisco, California); Mark Vander Wal (San Francisco, California); Jean-Marc M. Grandjean (San Francisco, California); Shigeo Yamanoi (San Francisco, California); Masahiro Inoue (San Francisco, California); Shimpei Hirano (San Francisco, California); Masatoshi Honzumi (San Francisco, California); Osamu Iwamoto (San Francisco, California); Koji Sasaki (San Francisco, California); Yamato Suzuki (San Francisco, California); Atsushi Tengeiji (San Francisco, California); Daniel R. Southworth (San Francisco, California); Darren Hutt (San Francisco, California); Jacob I. Ayers (San Francisco, California); Steven H. Olson (San Francisco, California); Cuong Quoc Ly (San Francisco, California); John West (San Francisco, California); Gregory E. Merz (San Francisco, California); Helene Viart (San Francisco, California) |
| ABSTRACT | A method for detecting a neurological disease the method comprising isolating brain tissue from its natural environment, contacting the brain tissue with a labeled molecule which binds to multiple sites of stacked proteins associated with neurodegenerative disease, determining the binding of the labeled molecule; and thereby determining a neurodegenerative disease associated with the brain tissue. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468639 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2800/2821 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201296 | SMALL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York); The Research Foundation for Mental Hygiene, Inc. (Menands, New York) |
| INVENTOR(S) | Scott A. SMALL (New York, New York); Jia GUO (New York, New York) |
| ABSTRACT | Methods for performing frequency and phase correction of magnetic resonance spectroscopy (MRS) data in quantifying one or more metabolites involved in the pathology of schizophrenia and related disorders. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/481551 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/485 (20130101) G01R 33/4625 (20130101) Original (OR) Class G01R 33/5608 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202914 | Dawant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benoit M. Dawant (Nashville, Tennessee); Jianing Wang (Nashville, Tennessee); Jack H. Noble (Nashville, Tennessee); Robert F. Labadie (Nashville, Tennessee) |
| ABSTRACT | Methods and systems for segmentation of structures of interest (SOI) in a CT image post-operatively acquired with an implant user in a region of interest in which an implant is implanted. The method includes inputting the post-operatively acquired CT (Post-CT) image to trained networks to generate a dense deformation field (DDF) from the input Post-CT image to an atlas image; and warping a segmentation mesh of the SOI in the atlas image to the input Post-CT image using the DDF so as to generate the segmentation mesh of the SOI in the input Post-CT image, wherein the segmentation mesh of the SOI in the atlas image is generated by applying an active shape model-based method to the atlas image. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 18/288058 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/02 (20240101) G06T 3/18 (20240101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/30 (20170101) G06T 17/20 (20130101) G06T 2207/10081 (20130101) G06T 2207/20132 (20130101) G06T 2207/30016 (20130101) G06T 2207/30048 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202915 | BUCKLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, January 17, 2024 |
| APPL NO | 18/415125 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240203290 | German et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CFD Research Corporation (Huntsville, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carrie Lynn German (Huntsville, Alabama); Balabhaskar Prabhakarpandian (Madison, Alabama); Ketan Harendrakumar Bhatt (Huntsville, Alabama) |
| ABSTRACT | A microfluidic in vitro cornea device is provided, which can include a tear flow chamber, stromal chamber, endothelial chamber, and aqueous humor chamber. The stromal chamber is adjacent to and porously coupled with the tear flow chamber. The endothelial chamber is adjacent to and porously coupled with the stromal chamber. The aqueous humor chamber adjacent to and porously coupled with the endothelial chamber. A first porous wall is positioned between the tear flow chamber and the stromal chamber. A second porous wall is positioned between the stromal chamber and the endothelial chamber. The third porous wall is positioned between the endothelial chamber and the aqueous humor chamber. The device is configured as a microfluidic in vitro model of a cornea. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541346 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/303 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240203440 | MESGARANI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Nima MESGARANI (New York, New York); Enea CEOLINI (New York, New York); Cong HAN (New York, New York) |
| ABSTRACT | Disclosed are methods, systems, device, and other implementations, including a method (performed by, for example, a hearing aid device) that includes obtaining a combined sound signal for signals combined from multiple sound sources in an area in which a person is located, and obtaining neural signals for the person, with the neural signals being indicative of one or more target sound sources, from the multiple sound sources, the person is attentive to. The method further includes determining a separation filter based, at least in part, on the neural signals obtained for the person, and applying the separation filter to a representation of the combined sound signal to derive a resultant separated signal representation associated with sound from the one or more target sound sources the person is attentive to. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530770 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 21/028 (20130101) Original (OR) Class G10L 21/0232 (20130101) G10L 2021/02087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240203540 | Lacey, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James V. Lacey, JR. (Monrovia, California); Jennifer Benbow (Monrovia, California); Emma Spielfogel (Monrovia, California); Kristen Savage (Monrovia, California); Sandeep Chandra (San Diego, California); Kai Lin (San Diego, California) |
| ABSTRACT | A method for self-service cohort selection may include receiving one or more user inputs specifying one or more cohort selection criteria. A script for accessing a first data store storing a first dataset may be generated based on the one or more cohort selection criteria. The script may be executed to retrieve, from the first dataset in the first data store, a subset of data. A second dataset corresponding to the first subset of data retrieved from the first data store may be generated for storage at the second data store. A visual representation of at least a portion of the second dataset may be generated for display at the client device. Related systems and computer program products are also provided. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/391041 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) Original (OR) Class G16H 10/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240197682 | Prusiner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Stanley B. Prusiner (San Francisco, California); Nick A. Paras (San Francisco, California); Jay Conrad (San Francisco, California); Ny Sin (San Francisco, California); Sandeep Raikar (San Francisco, California); Mark Vander Wal (San Francisco, California); Jean-Marc M. Grandjean (San Francisco, California); Shigeo Yamanoi (San Francisco, California); Masahiro Inoue (San Francisco, California); Shimpei Hirano (San Francisco, California); Masatoshi Honzumi (San Francisco, California); Osamu Iwamoto (San Francisco, California); Koji Sasaki (San Francisco, California); Yamato Suzuki (San Francisco, California); Atsushi Tengeiji (San Francisco, California); Daniel R. Southworth (San Francisco, California); Darren Hutt (San Francisco, California); Jacob I. Ayers (San Francisco, California); Steven H. Olson (San Francisco, California); Cuong Quoc Ly (San Francisco, California); John West (San Francisco, California); Gregory E. Merz (San Francisco, California); Helene Viart (San Francisco, California) |
| ABSTRACT | A method of inhibiting propagation of protein misfolding associated with a neurological disease, is carried out by contacting an environment populated with a propagating amyloid conformation of a protein (prion) associated with a neurological disease with molecules which binds multiple adjacent sites of the protein assemblies and allowing the molecules to bind multiple cites of the protein assemblies; and thereby impeding propagation of the disease-associated conformation of the protein in the environment. Drug/prion complexes are formed and uses of the drugs in detection and treatment of neurodegenerative diseases are disclosed. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468657 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/497 (20130101) A61K 31/499 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4162 (20130101) Original (OR) Class A61K 31/4245 (20130101) A61K 31/4375 (20130101) A61K 31/4725 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197744 | SHARIFI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nima SHARIFI (Cleveland, Ohio) |
| ABSTRACT | The present invention provides methods, kits, and compositions for treating sex steroid dependent cancer using BMX inhibitors. In certain embodiments, a sample from a subject having, or suspected of having, a sex steroid dependent disease cancer, is further assayed to determine: i) if the subject is heterozygous or homozygous for the HSD3B1(1245C) allele that encodes for the 3βSD1(367T) protein. In some embodiments, the BMX inhibitor comprises a monoclonal antibody or BMX binding portion thereof (e.g., zanubrutinib, acalabrutinib, abivertinib or ibrutinib). |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 18/557011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/4985 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2333/904 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197852 | Sanders et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina); UNITED STATES AS REPRESENTED BY SECRETARY OF NAVY (Silver Spring, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leigh Ann Sanders (Winston-Salem, North Carolina); John W. Sanders (Winston-Salem, North Carolina); Marlena Westcott (Winston-Salem, North Carolina); Kevin Porter (Silver Spring, Maryland) |
| ABSTRACT | The present invention relates to the fields of sexually transmitted disease and immunology. More specifically, but not exclusively, the invention provides a composition and methods to prepare and administer a vaccine for Neisseria gonorrhoede and/or other gram-negative bacteria such as by using psoralen-inactivated bacteria. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 18/556443 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/095 (20130101) Original (OR) Class A61K 39/105 (20130101) A61K 39/0258 (20130101) A61K 39/0283 (20130101) A61K 41/17 (20200101) A61K 2039/521 (20130101) A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240197977 — IMPROVED IMMUNE RESPONSE AND DECREASED IMMUNOPARALYSIS WITH IMMUNOMODULATING TREATMENT
| US 20240197977 | CHAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CYTOSORBENTS, INC. (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Phillip P CHAN (Princeton, New Jersey); Vincent J. CAPPONI (Princeton, New Jersey); Thomas D. Golobish (Princeton, New Jersey); Wei-Tai YOUNG (Princeton, New Jersey); Ophir ORTIZ (Princeton, New Jersey); Ritu TRIPATHI (Princeton, New Jersey) |
| ABSTRACT | The invention concerns methods of treating immunoparalysis by the attenuation via removal of inflammatory mediators and/or checkpoint inhibitor proteins in a subject, comprising treating a subject with a therapeutically effective amount of porous biocompatible polymer sorbent comprising a range of pore diameters between about 50 Å to about 3000 Å and a pore volume between about 0.5 cc/g to about 3.0 cc/g dry polymer; or comprising a range of pore diameters between about 50 Å to about 40,000 Å and a pore volume between about 0.5 cc/g to about 5.0 cc/g dry polymer. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/919053 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3679 (20130101) Original (OR) Class Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) B01J 20/28073 (20130101) B01J 20/28076 (20130101) B01J 20/28083 (20130101) B01J 20/28085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198417 | Darling et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristopher A. Darling (Havre de Grace, Maryland); Billy C. Hornbuckle (Bel Air, Maryland); Blake P. Fullenwider (Round Rock, Texas); Albert M. Ostlind (Aberdeen, Maryland); Anthony J. Roberts (Chesapeake City, Maryland); Anit K. Giri (Abingdon, Maryland) |
| ABSTRACT | A nano-structured alloy material includes a nanoparticle; a matrix phase surrounding the nanoparticle; and an alkali/alkali Earth metal to alter (i) a material property of the nanoparticle. (ii) a material property of the matrix phase, and (iii) an interaction of the nanoparticle with the matrix phase. |
| FILED | Wednesday, January 17, 2024 |
| APPL NO | 18/414714 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) Original (OR) Class B22F 1/065 (20220101) B22F 2301/10 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Alloys C22C 9/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198537 | Cardon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Lisa A. Cardon (Lake Tapps, Washington); Joshua A. Babst (Enumclaw, Washington); Alan S. Locke (Seattle, Washington); Michelle Crivella (Charleston, South Carolina); Eric Reid (Everett, Washington) |
| ABSTRACT | A system for processing a workpiece includes a robotic manipulator and an end effector coupled to a working end of the robotic manipulator. The end effector includes a machine tool and an end-effector vacuum clamp that is coupled to the machine tool. The end effector is releasably coupleable to a surface of the workpiece. A processing force is reacted through the end effector and to the workpiece. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068103 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/10 (20130101) B25J 9/0018 (20130101) B25J 9/0096 (20130101) B25J 9/1697 (20130101) B25J 11/005 (20130101) Original (OR) Class B25J 15/0019 (20130101) B25J 15/0057 (20130101) B25J 15/0616 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199468 | Gibson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. Gibson (Falls Church, Virginia); Daniel Rhonehouse (Chesapeake Beach, Maryland); Shyam S. Bayya (Ashburn, Virginia); L. Brandon Shaw (Woodbridge, Virginia); Rafael R. Gattass (Wahington, Delaware); Jesse A. Frantz (Washington, District of Columbia); Jason D. Myers (Alexandria, Virginia); Woohong Kim (Lorton, Virginia); Jasbinder S. Sanghera (Ashburn, Virginia) |
| ABSTRACT | This application relates generally to an optical fiber for the delivery of infrared light where the polarization state of the light entering the fiber is preserved upon exiting the fiber and the related methods for making thereof. The optical fiber has a wavelength between about 0.9 μm and 15 μm, comprises at least one infrared-transmitting glass, and has a polarization-maintaining (PM) transverse cross-sectional structure. The infrared-transmitting, polarization-maintaining (IR-PM) optical fiber has a birefringence greater than 10−5 and has applications in dual-use technologies including laser power delivery, sensing and imaging. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413911 |
| CURRENT CPC | Manufacture, Shaping, or Supplementary Processes C03B 37/023 (20130101) C03B 37/0122 (20130101) C03B 37/0279 (20130101) C03B 37/01217 (20130101) Original (OR) Class C03B 37/01222 (20130101) C03B 37/01225 (20130101) C03B 37/02709 (20130101) C03B 2201/86 (20130101) C03B 2203/34 (20130101) C03B 2203/302 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/005 (20130101) C03C 25/1063 (20180101) Optical Elements, Systems, or Apparatus G02B 6/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199508 | Ghiassi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kamran B. Ghiassi (Palmdale, California); Rusty L. Blanski (Santa Clarita, California); Nicolas Cena (Palmdale, California); Kellsie G. Knoerzer (Tehachapi, California) |
| ABSTRACT | The present invention relates to thruster propellants, processes of making thruster propellants and space vehicles comprising thrusters that employ such propellants. The disclosed thruster propellants are advantageous because do not readily uptake water and are conductive. Furthermore, when compared to previous thruster propellants they have a higher mass, a higher density and/or a lower surface tension. Thus, when used in a thruster, such propellants can generate equal or higher thrust than previous thruster propellants. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/077054 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/401 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 43/00 (20130101) Original (OR) Class Jet-propulsion Plants F02K 9/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199531 | Tan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loon-Seng Tan (Centerville, Ohio); Zhenning Yu (Beavercreek, Ohio) |
| ABSTRACT | A family of low-molecular-weight, main-chain thermotropic liquid-crystalline polyimides (TLC-PI) that are crosslinkable is disclosed. These all-aromatic TLC-PI are derived from (i) wholly aromatic and flexible diamine monomers, in which the linkage between the two aniline-ends contains a relatively high heat-tolerant but flexible chain constituted by two or more units of 1,4-phenoxy or 1,3-phenoxy or in combinations of both. Processes of making and using such all-aromatic TLC-PI is also provided. |
| FILED | Monday, February 12, 2024 |
| APPL NO | 18/438965 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 213/06 (20130101) C07C 217/90 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/1071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199604 | Prusiner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Stanley B. Prusiner (San Francisco, California); Nick A. Paras (San Francisco, California); Jay Conrad (San Francisco, California); Ny Sin (San Francisco, California); Sandeep Raikar (San Francisco, California); Mark Vander Wal (San Francisco, California); Jean-Marc M. Grandjean (San Francisco, California); Shigeo Yamanoi (San Francisco, California); Masahiro Inoue (San Francisco, California); Shimpei Hirano (San Francisco, California); Masatoshi Honzumi (San Francisco, California); Koji Sasaki (San Francisco, California); Yamato Suzuki (San Francisco, California); Atsushi Tengeiji (San Francisco, California); Daniel R. Southworth (San Francisco, California); Darren Hutt (San Francisco, California); Jacob I. Ayers (San Francisco, California); Steven H. Olson (San Francisco, California); Cuong Quoc Ly (San Francisco, California); John West (San Francisco, California); Gregory E. Merz (San Francisco, California); Helene Viart (San Francisco, California); Osamu Iwamoto (San Francisco, California) |
| ABSTRACT | The invention provides compounds, and methods of using those compounds to treat neurodegenerative diseases. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468633 |
| CURRENT CPC | Heterocyclic Compounds C07D 413/04 (20130101) C07D 413/14 (20130101) C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 491/048 (20130101) C07D 495/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199664 | Mirica et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); The Regents of the University of California (Oalkland, California) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire); The Regents of The University Of California (Oakland, California) |
| INVENTOR(S) | Katherine A. Mirica (Hanover, New Hampshire); Aylin Aykanat (Lyme, New Hampshire); Evan Cline (Lebanon, New Hampshire); Zheng Meng (West Lebanon, New Hampshire); Christopher G. Jones (Los Angeles, Canada); Hosea Nelson (Venice, California) |
| ABSTRACT | Embodiments of the present disclosure pertain to compositions that include a metal-organic framework. The metal-organic framework includes a plurality of metals and a plurality of ligands coordinated with the plurality of metals, where the plurality of metals include bismuth, and the plurality of ligands include a plurality of hydroxy moieties that are not part of carboxyl groups. At least some of the hydroxy moieties are coordinated with bismuth to form Bi—O bonds. The metal-organic framework is in the form of a conductive and interconnected network. Additional embodiments of the present disclosure pertain to methods of utilizing the compositions to detect analytes in a sample and shield various objects from radiation. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 18/286796 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/107 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/94 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 31/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199825 | Phillips et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boise State University (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Phillips (Boise, Idaho); Allison Christy (Nampa, Idaho) |
| ABSTRACT | The present disclosure relates to a nontoxic poly(ethyl cyanoacrylate) (PECA) plastic. The PECA-based plastic is sourced from non-petroleum feedstocks and can be thermally and/or mechanically converted back to the ethyl cyanoacrylate monomer in a closed-loop recycling system with high monomer recovery. The disclosure also provides for methods of making the PECA plastics and methods of recycling the PECA plastics. |
| FILED | Friday, August 18, 2023 |
| APPL NO | 18/452270 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 17/0404 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2049/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/247 (20130101) Original (OR) Class C08J 11/10 (20130101) C08J 2333/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199904 | Sullivan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick A. Sullivan (Cambridge, Massachusetts); Daniel J. Wilson (Medford, Massachusetts); Matthew Vallon (Boston, Massachusetts); Duncan Q. Bower (Winchester, Massachusetts); Leila F. Deravi (Cambridge, Massachusetts) |
| ABSTRACT | In some embodiments, an electrochromic pixel includes a first electrode having a first electrical lead facilitating a power supply connection and a second electrode having a second electrical lead facilitating the power supply connection. The electrochromic pixel further includes an electrolyte electrically connecting the first and second electrodes, and xanthommatin (Xa), or a derivative or precursor thereof, such that an electrical potential applied between the first electrode and the second electrode is configured to cause an oxidation or reduction of the xanthommatin (Xa), or a derivative or precursor thereof, thereby providing a change in reflected visible color of the Xa, or a derivative or precursor thereof. |
| FILED | Tuesday, June 06, 2023 |
| APPL NO | 18/330101 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/50 (20130101) C09D 11/52 (20130101) Original (OR) Class C09D 11/322 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/155 (20130101) G02F 1/157 (20130101) G02F 1/161 (20130101) G02F 1/163 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199973 | Collett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | METSS Corp. (Westerville, Ohio) |
| ASSIGNEE(S) | METSS Corp. (Westerville, Ohio) |
| INVENTOR(S) | Brian R. Collett (Columbus, Ohio); Angela Theys (Kansas City, Missouri); Michelle Docter (Columbus, Ohio); Joseph Sanders (Powell, Ohio); Kenneth J. Heater (Delaware, Ohio) |
| ABSTRACT | Lubricating compositions are described, the lubricating compositions comprising a base oil component and an additive component, wherein the additive component comprises a non-silicone anti-foaming agent. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/065878 |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 107/02 (20130101) C10M 129/76 (20130101) C10M 133/12 (20130101) C10M 133/42 (20130101) C10M 137/04 (20130101) C10M 141/10 (20130101) C10M 145/14 (20130101) C10M 161/00 (20130101) C10M 169/044 (20130101) Original (OR) Class Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2030/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200044 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Basil Hubbard (Cambridge, Massachusetts); Ahmed Hussein Badran (Cambridge, Massachusetts) |
| ABSTRACT | Engineered transcriptional activator-like effectors (TALEs) are versatile tools for genome manipulation with applications in research and clinical contexts. One current drawback of TALEs is that the 5′ nucleotide of the target is specific for thymine (T). TALE domains with alternative 5′ nucleotide specificities could expand the scope of DNA target sequences that can be bound by TALEs. Another drawback of TALEs is their tendency to bind and cleave off-target sequence, which hampers their clinical application and renders applications requiring high-fidelity binding unfeasible. This disclosure provides methods and strategies for the continuous evolution of proteins comprising DNA-binding domains, e.g., TALE domains. In some aspects, this disclosure provides methods and strategies for evolving such proteins under positive selection for a desired DNA-binding activity and/or under negative selection against one or more undesired (e.g., off-target) DNA-binding activities. Some aspects of this disclosure provide engineered TALE domains and TALEs comprising such engineered domains, e.g., TALE nucleases (TALENs), TALE transcriptional activators, TALE transcriptional repressors, and TALE epigenetic modification enzymes, with altered 5′ nucleotide specificities of target sequences. Engineered TALEs that target ATM with greater specificity are also provided. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/414114 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) A61K 48/0091 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/62 (20130101) C12N 15/90 (20130101) C12N 15/8509 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200049 | Isaacs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Farren Isaacs (Stamford, Connecticut); Miriam Amiram (Stamford, Connecticut); Adrian Haimovich (New Haven, Connecticut); Dieter Soll (Guilford, Connecticut) |
| ABSTRACT | Compositions, systems, and methods for preparation of polypeptides having multiple iterations of non-standard amino acids are provided. The compositions and method can be used to produce recombinant proteins at a greater yield than the same or similar polypeptides made using conventional compositions, systems, and methods. Accordingly, in some embodiments, the polypeptides are ones that could not be made using conventional methods and reagents, or could not be made a sufficient yield or purity to serve a practical purpose using conventional methods and reagents. Polypeptides made using the disclosed compositions, systems, and methods are also provided. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/194176 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/102 (20130101) C12N 15/1058 (20130101) Enzymes C12Y 601/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200050 | VAN DEVENTER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts) |
| INVENTOR(S) | James A. VAN DEVENTER (Medford, Massachusetts); Jessica T. STIEGLITZ (Medford, Massachusetts) |
| ABSTRACT | The invention provides aminoacyl-tRNA synthetases, compositions thereof, and methods for use thereof. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/513092 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/66 (20130101) Enzymes C12Y 601/01001 (20130101) C12Y 601/01004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200056 | Barbieri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Barbieri (Lindenhurst, New York); Farren Isaacs (Stamford, Connecticut) |
| ABSTRACT | Compositions and methods for gene editing are provided. The methods employ an oligo-based annealing mechanism that is rooted in the process of DNA replication rather than homologous recombination (HR). Oligo incorporation efficiencies are comparable and often exceed those of CRISPR/cas9 editing without the need for double strand breaks (DSBs). By relying on the multiplex annealing of oligos rather than DSBs the process is highly scalable across a genomic region of interest and can generate many scarless modifications of a chromosome simultaneously. Combinatorial genomic diversity can be generated across a population of cells in a single transformation event; genomic landscapes can be traversed through successive iterations of the process, and genome-wide changes can be massively parallelized and amplified through systematic strain mating. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/340687 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) C12N 15/1058 (20130101) Original (OR) Class C12N 15/1079 (20130101) C12N 15/1082 (20130101) C12N 15/1086 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2525/185 (20130101) C12Q 2543/10 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/06 (20130101) C40B 40/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200070 | Jewett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Joongoo Lee (Evanston, Illinois); Jeffrey S. Moore (Savoy, Illinois); Kenneth E. Schwieter (Champaign, Illinois); Kevin Jerome Schwarz (Champaign, Illinois) |
| ABSTRACT | Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/469530 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/351 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200130 | Joung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Vikram Pattanayak (Wellesley, Massachusetts); Karl Petri (Cambridge, Massachusetts) |
| ABSTRACT | Methods and compositions for performing highly sensitive in vitro assays to define substrate preferences and off-target sites of nucleic-acid binding, modifying, and cleaving agents. |
| FILED | Tuesday, January 02, 2024 |
| APPL NO | 18/402501 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1058 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200134 | Love et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | J. Christopher Love (Somerville, Massachusetts); Todd Michael Gierahn (Brookline, Massachusetts); Alexander K. Shalek (Lexington, Massachusetts); Marc Havens Wadsworth (Somerville, Massachusetts); Travis K. Hughes (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure describes improvements to both hardware and enzymatic reactions used in single cell analyses such as but not limited to Seq-well that enable significant increases in the yield of transcripts per cell, improved portability and case of use, increased scalability of the assay, and linkage of transcript information to other measurements made in the picowell arrays. |
| FILED | Thursday, August 10, 2023 |
| APPL NO | 18/448121 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 2200/0647 (20130101) B01L 2300/0681 (20130101) B01L 2300/0819 (20130101) B01L 2300/0829 (20130101) B01L 2300/0851 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1068 (20130101) C12N 15/1093 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) Original (OR) Class Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/2014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200894 | OPPENHEIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REBECCA T. OPPENHEIM (Huntsville, Alabama); Brian J. Smith (Huntsville, Alabama); Kevin D. Kennedy (Huntsville, Alabama) |
| ASSIGNEE(S) | the United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | REBECCA T. OPPENHEIM (Huntsville, Alabama); Brian J. Smith (Huntsville, Alabama); Kevin D. Kennedy (Huntsville, Alabama) |
| ABSTRACT | A firearm with a real-time cartridge counter display function, comprising a firearm body, a cartridge clip, a scope, and ammunition cartridge or cartridges loaded within the cartridge clip. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/082911 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 9/62 (20130101) Original (OR) Class Weapon Sights; Aiming F41G 1/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200997 | Simon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Nathaniel Simon (Princeton, New Jersey); Alexander Piqué (Princeton, New Jersey); David Snyder (Princeton, New Jersey); Kyle Ikuma (Norwood, New Jersey); Anirudha Majumdar (Hillsborough, New Jersey); Marcus Hultmark (Princeton, New Jersey) |
| ABSTRACT | Disclosed is a fast-response sensor system to measure a fluid vector in a plurality of dimensions. This system, known as ‘MAST’ (for MEMS Anemometry Sensing Tower), utilizes microelectromechanical (MEMS) hot-wire devices to produce a solid-state, lightweight, and robust flow sensor system suitable for, e.g., real-time wind estimation onboard a UAV. The MAST uses three through eighteen polygonally-arranged microscale flow sensors to determine the fluid's vector's direction and magnitude. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/367015 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/69 (20130101) G01F 1/696 (20130101) G01F 1/6845 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201205 | Prusiner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Stanley B. Prusiner (San Francisco, California); Nick A. Paras (San Francisco, California); Jay Conrad (San Francisco, California); Ny Sin (San Francisco, California); Sandeep Raikar (San Francisco, California); Mark Vander Wal (San Francisco, California); Jean-Marc M. Grandjean (San Francisco, California); Shigeo Yamanoi (San Francisco, California); Masahiro Inoue (San Francisco, California); Shimpei Hirano (San Francisco, California); Masatoshi Honzumi (San Francisco, California); Osamu Iwamoto (San Francisco, California); Koji Sasaki (San Francisco, California); Yamato Suzuki (San Francisco, California); Atsushi Tengeiji (San Francisco, California); Daniel R. Southworth (San Francisco, California); Darren Hutt (San Francisco, California); Jacob I. Ayers (San Francisco, California); Steven H. Olson (San Francisco, California); Cuong Quoc Ly (San Francisco, California); John West (San Francisco, California); Gregory E. Merz (San Francisco, California); Helene Viart (San Francisco, California) |
| ABSTRACT | A method for detecting a neurological disease the method comprising isolating brain tissue from its natural environment, contacting the brain tissue with a labeled molecule which binds to multiple sites of stacked proteins associated with neurodegenerative disease, determining the binding of the labeled molecule; and thereby determining a neurodegenerative disease associated with the brain tissue. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468639 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2800/2821 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240201257 — AUTOMATED TEST PATTERN GENERATION FOR TESTING DESIGN REDACTING RECONFIGURABLE HARDWARE
| US 20240201257 | Stitt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Greg M. Stitt (Gainesville, Florida); Swarup Bhunia (Gainesville, Florida); Naren Vikram Raj Masna (Gainesville, Florida); Aritra Dasgupta (Gainesville, Florida) |
| ABSTRACT | A method and system are directed to testing reconfigurable hardware designs, the method comprising inserting a scan chain into a reconfigurable hardware design associated with an integrated circuit comprising a redacted design; generating, using an automatic test pattern generation (ATPG) system, one or more test patterns and one or more bitstreams; receiving one or more primary outputs and contents of the scan chain from the reconfigurable hardware design by applying the one or more test patterns and the one or more bitstreams to the reconfigurable hardware design based on an ATPG test method of a plurality of ATPG test methods and a test architecture of a plurality of test architectures; comparing the one or more outputs and contents of the scan chain with one or more respective expected outcomes; and determining one or more faults associated with the reconfigurable hardware design based on the comparison. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/536973 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/318307 (20130101) Original (OR) Class G01R 31/318525 (20130101) G01R 31/318536 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240201397 — SYSTEM AND METHOD FOR SURVEYING A NON-STATIONARY PLATFORM SUBJECT TO THERMAL EXPANSION
| US 20240201397 | Keti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matt Keti (Alta Loma, California); Jason Burke (Placentia, California) |
| ABSTRACT | A method includes obtaining an initial survey of multiple receivers located on a dynamic platform. The method also includes obtaining sensor readings from the multiple receivers. The method further includes validating, using a differential calculator, the initial survey by (i) selecting a reference receiver and a target receiver from among the multiple receivers and (ii) calculating, based on the sensor readings and baselines between the reference receiver and one or more remaining receivers, a platform attitude, platform thermal expansion state, and survey error values corresponding to the target receiver. The method also includes, starting from a validated survey, adding a new receiver to the initial survey by (i) determining a baseline between the reference receiver and the new receiver and (ii) associating the baseline to a coordinate frame of the initial survey. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066395 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/15 (20130101) G01S 19/41 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201563 | Ledezma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Luis M. Ledezma (La Crescenta, California); Alireza Marandi (Pasadena, California); Robert M. Gray (Pasadena, California); Benjamin K. Gutierrez (Redondo Beach, California) |
| ABSTRACT | On-chip generation of coherent radiation, i.e. laser-like radiation, can be tuned over broad and/or hard-to-access wavelength regions in an integrated platform. Target spectral coverage is beyond what could be achieved with existing integrated laser systems. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/543950 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/39 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/50 (20130101) H01S 5/125 (20130101) H01S 5/141 (20130101) H01S 5/0265 (20130101) H01S 5/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202066 | Butts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Corey L. Butts (Warren, Ohio); Rashmi Jha (Cincinnati, Ohio); Temesgen Messay Kebede (Dayton, Ohio); David Anthony Kapp (Miamisburg, Ohio) |
| ABSTRACT | Systems and methods disclosed herein provide training an artificial neural network (ANN) on buffered input and output samples of an original component within a system such that the ANN is configured to produce a degenerate component, the degenerate component configured to generate the same outputs as the original component; comparing the outputs from the original component to outputs of the degenerate component during actual component operation; and in the event of a failure of the original component, replacing the original component with the degenerate component. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/539778 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/079 (20130101) G06F 11/0793 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202116 | Kotra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | Jagadish B. Kotra (Austin, Texas); John Kalamatianos (Arlington, Massachusetts); Paul James Moyer (Fort Collins, Colorado); Nicholas Dean Lance (Windsor, Colorado); Sriram Srinivasan (Cedar Park, Texas); Patrick James Shyvers (Fort Collins, Colorado); William Louie Walker (Fort Collins, Colorado) |
| ABSTRACT | An entry of a last level cache shadow tag array to track pending last level cache misses to private data in a previous level cache (e.g., an L2 cache), that also are misses to an exclusive last level cache (e.g., an L3 cache) and to the last level cache shadow tag array. Accordingly, last level cache miss status holding registers need not be expended to track cache misses to private data that are already being tracked by a previous level cache miss status holding register. Additionally or alternatively, up to a threshold number of last level cache pending misses to the same shared data from different processor cores are tracked in the last level cache shadow tag array, and any additional last level cache pending misses are tracked in a last level cache miss status holding register. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068930 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0802 (20130101) Original (OR) Class G06F 2212/1016 (20130101) G06F 2212/1028 (20130101) G06F 2212/1044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202234 | Kathol et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andreas Kathol (El Cerrito, California); Colleen Richey (Foster City, California); Victor Abrash (Montara, California); Homin Kwon (San Diego, California) |
| ABSTRACT | Techniques are disclosed for searching audio recordings in a second language with a key phrase in a first language. For example, a system as described herein receives a first key phrase in the first language and an audio recording in the second language. The system converts the first key phrase into a second key phrase in the second language. The system processes the second key phrase to produce a second key phrase variant. The system identifies, from a graph of words in the second language generated from the audio recording, instances of the second key phrase or the second key phrase variant within the audio recording. The system displays the identified instances of the second key phrase or the second key phrase variant within the audio recording to enhance searchability of the audio recording in the second language. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 18/555077 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/632 (20190101) Original (OR) Class G06F 16/683 (20190101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/005 (20130101) G10L 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202405 | LANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ObjectSecurity LLC (San Diego, California) |
| ASSIGNEE(S) | ObjectSecurity LLC (San Diego, California) |
| INVENTOR(S) | Ulrich LANG (San Diego, California); Reza FATAHI (Encino, California); Jason KRAMER (Studio City, California); Brendan WEIBEL (Bellevue, Washington) |
| ABSTRACT | Method and system for analyzing a computing system for properties of a machine learning model in the computing system include loading input data for the machine learning model; generating a surrogate model that simulates the behavior and/or characteristics, or an approximation of the behavior and/or the characteristics of the machine learning model, by using segments or an entirety of the loaded input data; adjusting the input data and/or the surrogate model to enable an analysis; loading and executing the analysis of a correlation between inputs and outputs of the surrogate model to identify a result pertaining to the input data and/or the machine learning model; generating an output data describing the result; storing the output data pertaining to the result in the memory; determining if the result satisfies a predetermined condition, and if so, executing an action corresponding to the result on the computing system. |
| FILED | Friday, May 12, 2023 |
| APPL NO | 18/196950 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/27 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202525 | Narain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Perspecta Labs Inc. (Basking Ridge, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanjai Narain (Basking Ridge, New Jersey); Emily Chun Mak (Basking Ridge, New Jersey) |
| ABSTRACT | In a computer-implemented method, computer program product, and computer system, program code executing on a processor(s) generates input-output pairs, to form a training set for machine learning and generates a machine learning model of a cyber physical system by utilizing a machine learning algorithm and the training set to train the machine learning model. The program code converts the trained machine learning model into an equivalent constraint and optimizes objective functions subject to the constraint by utilizing one or more constraint solvers to compute an input-output pair. The program code determines if the computed input-output pair, is within an error tolerance and based on determining that it is, either utilizes it as a solution or adds it to the training set (and continues training). If the pair is not within the tolerance, the program code utilizes it as a solution or adds it to the training set (and continues training). |
| FILED | Friday, December 13, 2019 |
| APPL NO | 16/713779 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202538 | NADAMUNI RAGHAVAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aswin NADAMUNI RAGHAVAN (Pennington, New Jersey); Indranil SUR (Plainsboro, New Jersey); Zachary DANIELS (Robbinsville, New Jersey); Jesse HOSTETLER (Boulder, Colorado); Abrar RAHMAN (Brooklyn, New York); Ajay DIVAKARAN (Monmouth Junction, New Jersey); Michael R. PIACENTINO (Southern Shores, North Carolina) |
| ABSTRACT | A method, apparatus and system for lifelong reinforcement learning include receiving features of a task, communicating the task features to a learning system, where the learning system learns or performs a task related to the features based on learning or performing similar previous tasks, determining from the features if the task has changed and if so, communicating the features of the changed task to the learning system, where the learning system learns or performs the changed task based on learning or performing similar previous tasks, automatically annotating feature characteristics of received features including differences between the features of the original task and the features of the changed task to enable the learning system to more efficiently learn or perform at least the changed task, and if the task has not changed, processing the task features of a current task by the learning system to learn or perform the current task. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535928 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/092 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202625 | Simeone et al. |
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| FUNDED BY |
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| APPLICANT(S) | Michael P. Simeone (Scottsdale, Arizona); David Little (Mesa, Arizona); George Boben (Fort Worth, Texas); Shashank Kapoor (New Delhi, India); Deepan Nedumaran (Tempe, Arizona); Aravind Sundaresan (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. Simeone (Scottsdale, Arizona); David Little (Mesa, Arizona); George Boben (Fort Worth, Texas); Shashank Kapoor (New Delhi, India); Deepan Nedumaran (Tempe, Arizona); Aravind Sundaresan (Tempe, Arizona) |
| ABSTRACT | A system for failure detection tools is disclosed. The system may include at least one user device, an application server, and a failure detection system, each of which may be in communication with one or more of the others via at least one network. The failure detection system may receive first data from a data source, process the first data to generate second data, apply a statistical modeling algorithm to make a prediction relating to the first data or the second data, and communicate data relating to the prediction and/or a trend related to the first data or the second data to the user device for displaying at least a portion of the data relating to the prediction and/or the trend on a display of the user device. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/423637 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/54 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0633 (20130101) G06Q 10/06312 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240203623 | WILBER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Metamagnetics, Inc. (Marlborough, Massachusetts) |
| ASSIGNEE(S) | Metamagnetics, Inc. (Marlborough, Massachusetts) |
| INVENTOR(S) | William D. WILBER (Killingworth, Connecticut); Taylor G. TROTTIER (Worcester, Massachusetts); Jacob G. REMZ (Marlborough, Massachusetts); Scott M. GILLETTE (Norfolk, Massachusetts) |
| ABSTRACT | Embodiments of the present disclosure relate to magnetostatic wave (MSW) radio frequency (RF) apparatuses, components thereof, and related techniques. In some embodiments, an MSW RF apparatus may be operated at a certain temperature. That temperature may be substantially stable over a range of ambient temperatures. In some embodiments, the substantially stable temperature may be provided by a temperature controllable enclosure, such as a mini-oven or thermoelectric cooler. In some embodiments, a MSW RF apparatus may include a ferrite through which electromagnetic energy is passed. In some embodiments, the ferrite may be doped to change its saturation magnetization. In some embodiments, a MSW RF apparatus may include a biasing magnet to apply a magnetic bias to the ferrite. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390353 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/344 (20130101) Original (OR) Class H01F 7/064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204090 | Sharma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GlobalFoundries U.S. Inc. (Malta, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Santosh Sharma (Austin, Texas); Mark D. Levy (Williston, Vermont) |
| ABSTRACT | A disclosed structure includes an enhancement mode high electron mobility transistor (HEMT). The HEMT includes a barrier layer with a thick portion positioned laterally between thin portions and a gate. The gate includes a semiconductor layer (e.g., a P-type III-V semiconductor layer) on the thick portion of the barrier layer and having a thick portion positioned laterally between thin portions. The gate also includes a gate conductor layer on and narrower than the thick portion of the semiconductor layer, so end walls of the gate are stepped. Thin portions of the barrier layer near these end walls minimize or eliminate charge build up in a channel layer below. To block current paths around the gate, isolation regions can be below the thin portions of the barrier layer offset from the semiconductor layer. The structure can further include alternating e-mode and d-mode HEMTs. Also disclosed are associated method embodiments. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/065674 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/32139 (20130101) H01L 29/0642 (20130101) H01L 29/0891 (20130101) H01L 29/1029 (20130101) H01L 29/2003 (20130101) H01L 29/7786 (20130101) Original (OR) Class H01L 29/66462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204538 | ZIMMERMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Albert ZIMMERMAN (El Segundo, California) |
| ABSTRACT | Monitoring self-discharge in operating battery cells (i.e., actively charging or discharging) is disclosed. Cell voltage data over time is used to detect cell-to-cell charge voltage imbalance in a battery while battery cells are at their peak charge voltage. Resistors across each cell are switched on or off according to the average charge voltage imbalance. Actual resistor on-times are used as input to train a neural network in real time. The neural network learns the resistor duty cycle needed by each battery cell to precisely balance its self-discharge losses. If the self-discharge changes, the neural network retrains itself as the new data arrives. The neural network may include a Long Short-Term Memory (LSTM) network for each cell in the battery, which can learn the relative self-discharge rate of the respective cell. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067424 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/367 (20190101) G01R 31/396 (20190101) G01R 31/3835 (20190101) Computer Systems Based on Specific Computational Models G06N 3/045 (20230101) G06N 3/0442 (20230101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0016 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204764 | Sharma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GlobalFoundries U.S. Inc. (Malta, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Santosh Sharma (Austin, Texas); Johnatan Avraham Kantarovsky (South Burlington, Vermont); Rajendran Krishnasamy (Essex Junction, Vermont) |
| ABSTRACT | An integrated circuit (IC) having a high voltage semiconductor device with a plurality of field plates between the gate and drain. The IC further includes a biasing circuit electrically coupled to each of the plurality of field plates, the biasing circuit including a plurality of high voltage depletion mode transistors, each having a pinch off voltage. The high voltage depletion mode transistors may have different pinch off voltages, and each of the field plates are each independently biased by a different one of the high voltage depletion mode transistors. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/065768 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/404 (20130101) H01L 29/7816 (20130101) Pulse Technique H03K 17/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204788 | UTTER |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Alexander Clifton UTTER (Hawthorne, California) |
| ABSTRACT | An apparatus that measures elapsed time in digital systems with multiple clocks includes a vernier reference (VREF) configured to generate a reference counter signal with a numeric output and two reference clock signals. The apparatus also includes a plurality of synchronizer VPLLs configured to receive the reference counter signal and the two reference clock signals and generate a plurality of synchronized counters, each synchronized counter being co-linear with the reference counter and operating in a respective target clock domain. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066542 |
| CURRENT CPC | Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/07 (20130101) H03L 7/087 (20130101) H03L 7/0992 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240205083 | Yeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edmund Meng Yeh (Newton, Massachusetts); Khashayar Kamran (Allston, Massachusetts) |
| ABSTRACT | A framework for joint computation, caching, and request forwarding in data-centric computing-based networks comprises a virtual control plane, which operates on request counters for computations and data, and an actual plane, which handles computation requests, data requests, data objects and computation results in the physical network. A throughput optimal policy, implemented in the virtual plane, provides a basis for adaptive and distributed computation, caching, and request forwarding in the actual plane. The framework provides superior performance in terms of request satisfaction delay as compared with several baseline policies over multiple network topologies. |
| FILED | Thursday, February 29, 2024 |
| APPL NO | 18/591973 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/547 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/082 (20130101) Original (OR) Class H04L 67/10 (20130101) H04L 67/568 (20220501) H04L 69/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240205095 | BERTIZZOLO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lorenzo BERTIZZOLO (Boston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts); Salvatore D'ORO (Allston, Massachusetts); Hai CHENG (Boston, Massachusetts) |
| ABSTRACT | Provided herein are systems for controlling a network of distributed non-terrestrial nodes including a control framework operative to train and control a plurality of the non-terrestrial nodes, the control framework including a control interface in communication with a network operator to receive one or more specified control objectives, and a learning engine operative to train a virtual non-terrestrial network, wherein the control framework is further operative to transfer knowledge gained through the training of the virtual non-terrestrial network to the network of distributed non-terrestrial nodes as data-driven logic unit configurations tailored for the specified control objectives. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846197 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/122 (20220501) Original (OR) Class Wireless Communication Networks H04W 84/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240205153 | Kunc et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MIMYR, LLC (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Kunc (Rancho Palos Verdes, California); Andrew Hung (Los Angeles, California); David Wang (Rancho Palos Verdes, California); Michael Mavraganis (Rancho Palos Verdes, California) |
| ABSTRACT | This application relates to a distributed software-defined network (“DSDN”) for dynamically configuring and managing a wireless communication network. A plurality of DSDN nodes are connected to each other via a plurality of communication paths. Each communication path directly connects two DSDN nodes. Each DSDN node can provide DSDN configurations across diverse and disparate networks by normalizing its data plane network traffic through translation and packet encapsulation. Furthermore, the DSDN node can provide an architecture tolerant of network interruptions and network system fluctuations. For example, in the case of any one of the DSDN node's network interruptions from other DSDN nodes, the DSDN can provide network reconfiguration using network configuration rules stored in a control plane of each DSDN node. Therefore, various embodiments can increase network reliability by the multiple nodes within a software-defined network independently managing its control plane in response to changed network conditions. |
| FILED | Friday, January 19, 2024 |
| APPL NO | 18/418000 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/02 (20130101) H04L 45/74 (20130101) H04L 45/76 (20220501) Original (OR) Class H04L 69/22 (20130101) Wireless Communication Networks H04W 24/02 (20130101) H04W 40/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240205171 | Ho |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thang Hoang Ho (San Diego, California) |
| ABSTRACT | A dynamically reconfigurable network presents external ports. The dynamically reconfigurable network includes a configuration register, a physical layer, and protocol stacks. The configuration register dynamically specifies a particular configuration selected from available configurations of the dynamically reconfigurable network. The physical layer interconnects ports with multiplexing controlled by the configuration register for realizing the available configurations capable of connecting from each of the ports to any one or more of the ports. The particular configuration from the configuration register specifies current connections to each of the ports from a respective one of the ports. The ports include the external ports of the dynamically reconfigurable network and internal ports. The protocol stacks each include at least a routing layer and a switching layer, with the switching layer connected to at least one of the internal ports. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/081841 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/084 (20130101) H04L 41/0893 (20130101) H04L 49/90 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240205563 | Beerel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Beerel (Los Angeles, California); Gourav Datta (Los Angeles, California); Ajey P. Jacob (Watervliet, New York); Akhilesh Jaiswal (Madison, Wisconsin); Zihan Yin (Los Angeles, California) |
| ABSTRACT | Provided is an integrated circuit comprising: a sensor structure; a set of weighting elements, each configured to weight an output of the sensor structure; and an output element, the output element configured to collect weighted outputs of the set of weighting elements. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545859 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 24/16 (20130101) H01L 27/14634 (20130101) H01L 2224/16145 (20130101) H01L 2224/16225 (20130101) Pictorial Communication, e.g Television H04N 25/77 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240198315 | TRIVELPIECE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CORY L. TRIVELPIECE (AIKEN, South Carolina); MADISON C. HSIEH, II (AIKEN, South Carolina); AUSTIN STANFIELD (AIKEN, South Carolina) |
| ABSTRACT | In one aspect, a functionalized porous material includes a synthetic porous material, the synthetic porous material comprising a surface, wherein at least a portion of the synthetic porous material surface is a substrate; and a mixed-metal hydroxide, wherein the mixed-metal hydroxide is affixed to the substrate. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/082006 |
| CURRENT CPC | Separation B01D 39/2003 (20130101) B01D 39/2027 (20130101) B01D 39/2068 (20130101) B01D 2239/0414 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/08 (20130101) B01J 20/3204 (20130101) B01J 20/3221 (20130101) B01J 20/3236 (20130101) B01J 20/3242 (20130101) B01J 20/28042 (20130101) Original (OR) Class B01J 47/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198317 | KANAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew W. KANAN (Palo Alto, California); Amy Delano FRANKHOUSER (Oakland, California); Chastity S. LEE (Palo Alto, California) |
| ABSTRACT | A catalyst for performing the reverse-water-gas-shift (RWGS) reaction is provided comprising an alkali carbonate dispersed on a porous support. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 18/555826 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/04 (20130101) Original (OR) Class B01J 35/80 (20240101) Non-metallic Elements; Compounds Thereof; C01B 32/40 (20170801) Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide C10K 3/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199455 | Custelcean et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radu Custelcean (Knoxville, Tennessee); Jeffrey Einkauf (Knoxville, Tennessee) |
| ABSTRACT | Method for removing toxic oxyanions (e.g., selenate) from an aqueous source as follows: (i) dissolving an oxyanion precipitating compound (OPC) in the aqueous source to result in precipitation of a salt containing sulfate, toxic oxyanion, and the OPC, wherein the sulfate in the aqueous source is in a molar concentration at least equal to the total molar concentration of the toxic oxyanion, and the OPC is included in the aqueous source in a molar concentration equal to or greater than the total molar concentration of sulfate and toxic oxyanion; and (ii) removing the precipitated salt from the aqueous source to result in a supernatant containing a substantially lower concentration of the toxic oxyanion compared to the aqueous source. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/371528 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/5272 (20130101) Original (OR) Class C02F 2101/106 (20130101) Acyclic or Carbocyclic Compounds C07C 279/00 (20130101) Heterocyclic Compounds C07D 213/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199456 | Sant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav Sant (Los Angeles, California); Xin Chen (Los Angeles, California); Dante Simonetti (Los Angeles, California); Steven Bustillos (Los Angeles, California); David Jassby (Los Angeles, California) |
| ABSTRACT | The present disclosure describes methods of deacidifying and dechlorinating an aqueous solution using a deacidifying and dechlorinating composition. The present methods advantageously produce a dechlorinated brine solution have a neutral to alkaline pH. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511368 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/66 (20130101) Original (OR) Class C02F 2101/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199512 | ACHINIVU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ezinne ACHINIVU (Alexandria, Virginia); Mood MOHAN (Emeryville, California); Hemant CHOUDHARY (Emeryville, California); Lalitendu DAS (Emeryville, California); Venkataramana R. PIDATALA (Emeryville, California); Harsha D. MAGURUDENIYA (Newport News, Virginia); Kaixuan HUANG (Albany, California); John M. GLADDEN (Alameda, California); Blake A. SIMMONS (San Francisco, California) |
| ABSTRACT | The present invention provides for a method to deconstruct a biomass: the method comprising: (a) introducing a solvent comprising a polyamine, or a mixture of polyamines, to a biomass to dissolve at least part of solid biomass in the solvent, wherein the polyamine is a Brønsted or Lewis base, and/or the polyamine is a hydrogen bond donor and/or acceptor; (b) optionally introducing an enzyme and/or a microbe to the solubilized biomass mixture such that the enzyme and/or microbe produces a sugar from the solubilized biomass mixture; (c) optionally separating the sugar from the solubilized biomass mixture; and (d) optionally separating the lignan from the solubilized biomass mixture. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/393900 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199566 | Huber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | George Huber (Middleton, Wisconsin); Raka Dastidar (Madison, Wisconsin); Sam Johnstone (Madison, Wisconsin); Daniel McClelland (Fitchburg, Wisconsin) |
| ABSTRACT | A method to make delta-valerolactone (“DVL”) by dehydrogenating 2-hydroxytetrahydropyran (“HTHP”). The HTHP is contacted with a supported-metal catalyst for a time, at a temperature, and at a pressure wherein at least a portion of the HTHP is converted to DVL via dehydrogenation of the HTHP. The HTHP may be derived from biomass. Thus, the method yields DVL without requiring a petroleum-based feedstock. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/510856 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 21/08 (20130101) B01J 21/10 (20130101) B01J 23/42 (20130101) B01J 23/44 (20130101) B01J 23/72 (20130101) B01J 23/755 (20130101) Heterocyclic Compounds C07D 309/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199663 | Attah-Poku et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Saskatchewan (Saskatoon, Canada); Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Attah-Poku (Saskatoon, Canada); George Mutwiri (Saskatoon, Canada); Sylvia Van Den Hurk (Saskatoon, Canada); Jan Van Den Hurk (Saskatoon, Canada); John Klaehn (Idaho Falls, Idaho); Volker Gerdts (Saskatoon, Canada) |
| ABSTRACT | Disclosed herein are cyclopolyphosphazenes of formula I: methods for the preparation thereof and uses thereof in adjuvant compositions. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 18/556667 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 2039/55511 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65815 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199807 | NASKAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit K. NASKAR (Knoxville, Tennessee); Jiho SEO (Buford, Georgia); Sargun Singh ROHEWAL (Knoxville, Tennessee); Michael TOOMEY (Oak Ridge, Tennessee); Logan T. KEARNEY (Knoxville, Tennessee); Joshua T. DAMRON (Knoxville, Tennessee) |
| ABSTRACT | A crosslinked polymeric composition comprising the following components: (i) a matrix comprising an epoxy-anhydride crosslinked polymer containing a multiplicity of ester linkages resulting from reaction between epoxy-containing and anhydride-containing molecules; and (ii) a hydroxy-containing solid filler component integrated into component (i) and engaged in dynamic reversible covalent crosslinking with component (i) by a reversible exchange reaction between the ester linkages and hydroxy groups in the hydroxy-containing solid filler; wherein the crosslinked polymeric composition behaves as a thermoset up to a temperature X and behaves as a processible thermoplastic at a temperature greater than X. Also described herein is a method for producing the above composition comprising combining and mixing the following components: (a) epoxy-containing molecules, (b) anhydride-containing molecules, (c) a hydroxy-containing solid filler, and (d) a catalyst that promotes curing between epoxy and anhydride groups, followed by heating of the resultant mixture to a temperature of least 100° C. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/532599 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/2615 (20130101) Original (OR) Class C08G 65/2642 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/00 (20130101) C08K 11/005 (20130101) C08K 2201/014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199937 | Kaur et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sumanjeet Kaur (Pinole, California); Ravi S. Prasher (Danville, California); Sean Lubner (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to thermal insulation. In one aspect, a composite includes a plurality of silica nanoparticles and a plurality of first nanoparticles. The plurality of silica nanoparticles comprise about 70 wt % to 98 wt % of the composite. The plurality of first nanoparticles comprising about 2 wt % to 30 wt % of the composite. |
| FILED | Monday, November 27, 2023 |
| APPL NO | 18/519315 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199966 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xianhui Zhao (Knoxville, Tennessee); Oluwafemi Oyedeji (Knoxville, Tennessee); Soydan Ozcan (Oak Ridge, Tennessee); Halil Tekinalp (Knoxville, Tennessee); Erin G. Webb (Luttrell, Tennessee) |
| ABSTRACT | A method for fractionating biomass material according to ash content, the method comprising: grinding the biomass material to produce a ground biomass and sieving the ground biomass through a first screen to yield: a) a first fraction of biomass particles that does not pass through the first screen and which has a first particle size, and b) a second fraction of biomass particles that passes through the first screen and which has a second particle size, wherein the second particle size is smaller than the first particle size, and wherein the second fraction of biomass particles has a higher ash content than the first fraction of biomass particles; and optionally further comprising: passing the second fraction of biomass particles through a second screen having a finer mesh size to produce a third fraction having a smaller particle size and a higher ash content than the second fraction of biomass particles. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/373400 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 97/02 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 5/445 (20130101) Original (OR) Class C10L 2200/024 (20130101) C10L 2200/0209 (20130101) C10L 2200/0213 (20130101) C10L 2200/0218 (20130101) C10L 2200/0236 (20130101) C10L 2200/0484 (20130101) C10L 2250/06 (20130101) C10L 2290/08 (20130101) C10L 2290/28 (20130101) C10L 2290/546 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200103 | ALEXANDER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Gerald ALEXANDER (Madison, Wisconsin); David Peris NAVARRO (Madison, Wisconsin); Christopher Todd HITTINGER (Madison, Wisconsin) |
| ABSTRACT | Methods of making synthetic yeast cells by mating together two diploid (or higher ploidy) yeast species or hybrids to generate multiploid yeast hybrids are provided herein. The synthetic yeast cells made by this process and kits for performing the process are also provided. |
| FILED | Friday, January 19, 2024 |
| APPL NO | 18/417305 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/18 (20130101) C12N 9/16 (20130101) C12N 15/65 (20130101) C12N 15/81 (20130101) C12N 15/905 (20130101) Original (OR) Class C12N 2800/80 (20130101) C12N 2840/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200162 | Das et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Phinix, LLC (Clayton, Missouri); Virginia Tech Intellectual Properties, Inc. (Blackburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Subodh Das (Clayton, Missouri); Wencai Zhang (Blackburg, Virginia) |
| ABSTRACT | The present disclosure concerns processes and the combinations thereof for the enrichment and/or isolation of valuable metals from municipal solid waste incineration (MSWI) ash. Included are processes of size separation, froth floatation, magnetic separation, specific gravity separation, chemical separation, as well as the removal of lime. BY utilizing two or more, circuits of treatment are also provided that allow for fractionation of enriched valuable metals(s) from which purification thereof can be readily achieved. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/514620 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 1/24 (20130101) C22B 7/007 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200173 | Muralidharan et al. |
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| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); Leggera Technologies LLC (Orion Township, Michigan); FCA US LLC (Auburn Hills, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Govindarajan Muralidharan (Knoxville, Tennessee); Bryan Macek (Auburn Hills, Michigan); Nathan Sanko (Orion Township, Michigan) |
| ABSTRACT | A magnesium alloy includes, in weight percent Al: 4.5-6.5; Zn: 0.05-3.0; Ca: 0-1.5; Sn: 0-4.0; Mn: 0.1-0.5; Si: 0-0.5; B+Sr: 0-0.5; less than 0.1 Fe; less than 0.1 Cu; less than 0.01 Ni; and Mg: Balance. A process for thixomolding, and a large dimension magnesium alloy article are also disclosed. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/375301 |
| CURRENT CPC | Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 21/007 (20130101) Alloys C22C 23/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200209 | ALLEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert David ALLEN (Golden, Colorado); Kenneth Charles NEYERLIN (Denver, Colorado); Michael McGRAW (Lakewood, Colorado) |
| ABSTRACT | Electrochemical CO2 reduction is a promising technology to capture and convert CO2 to valuable chemicals. Disclosed herein is the effect of anolyte on the effective morphology (i.e. ionic accessibility) of a CO2 reduction cathode using electrochemical techniques and cell configurations that avoid the complexities related to co-electrolysis (oxygen evolution reaction at anode). When KOH is utilized as the anolyte the effective morphology of the cathode is enhanced, facilitating the CO2 reduction kinetics via improved electrocatalyst accessibility |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/544107 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/26 (20210101) Original (OR) Class C25B 11/042 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200892 | Nawaz et al. |
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| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kashif Nawaz (Knoxville, Tennessee); Cheng-Min Yang (Oak Ridge, Tennessee) |
| ABSTRACT | A boiling heat exchange system includes a heat exchanger including a chamber configured to hold a heat exchange fluid including a heat exchange vapor and a pool of heat exchange liquid and an evaporator tube having an outer surface and a thermally conductive open-cell porous material disposed on the outer surface and comprising a plurality of pores. The evaporator tube can be immersed in the heat exchange liquid held in the chamber and the heat exchange liquid will enter the pores. The open-cells of the open-cell porous material will heat the heat exchange liquid to cause the heat exchange liquid to boil to a heat exchange vapor and exchange heat with a source fluid flowing through the evaporator tube or with a component in thermal contact with the evaporator. A method of performing heat exchange is also disclosed. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/375072 |
| CURRENT CPC | Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/003 (20130101) Original (OR) Class F28F 13/187 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201014 | Erskine |
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| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David J. Erskine (Oakland, California) |
| ABSTRACT | Methods, systems and devices are described that improve optical spectroscopic techniques and particularly those that involve externally dispersed interferometer (EDI) techniques that result in an output spectrum having improved stability characteristics. The output spectrum minimizes the unwanted shifts in wavelength when the spectrograph component of the EDI instrument is under stresses that would otherwise shift or distort the wavelength positions of the spectrum. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066899 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/45 (20130101) Original (OR) Class G01J 2003/283 (20130101) G01J 2003/451 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201074 | Alden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Caroline B. Alden (Boulder, Colorado); Sean C Coburn (Longmont, Colorado); Robert J. Wright (Boulder, Colorado); Gregory B. Rieker (Boulder, Colorado) |
| ABSTRACT | A dual-beam optomechanical steerer includes first and second rotators mounted to a two-axis gimbal system. Each rotator is adjustable to control the azimuthal and elevation angles at which an optical transmitter affixed to the rotator transmits a beam of light. Thus, the two-axis gimbal system orients two optical transmitters identically while the first and second rotators orient the two optical transmitters independently with respect to the two-axis gimbal system. Examples of each rotator include a tip-tilt stage, goniometer, and rotation stage. Alternatively, a deflector may be used instead of each rotator. Examples of the deflector include an acousto-optic deflector, translatable lens, and Risley prism. The dual-beam steerer may be used to perform remote gas detection with two separate optical beams. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/286101 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) Original (OR) Class G01N 33/0027 (20130101) G01N 2201/104 (20130101) Optical Elements, Systems, or Apparatus G02B 26/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201105 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EPIR, Inc. (Bolingbrook, Illinois) |
| ASSIGNEE(S) | EPIR, Inc. (Bolingbrook, Illinois) |
| INVENTOR(S) | Issac L. Chang (Naperville, Illinois); Sushant Sonde (Darien, Illinois); Silviu Velicu (Willowbrook, Illinois); Yong Chang (Naperville, Illinois) |
| ABSTRACT | A method of contactless, non-destructive contamination-free 2-dimensional mapping of the cutoff wavelength (or bandgap) and the minority carrier lifetime, which is measured through photo-excited excess free carrier absorption decay method, in semiconductor thin film materials and wafers, including typical semiconductor wafers such as Si, Ge, GaAs, and GaSb as well as narrow gap semiconductors such as InSb, type II superlattices (T2SLs) and HgCdTe, at variable temperatures from room temperature down to 2K, utilizing a three-chamber arrangement in which the external chamber and cold chamber are held at ultra-high vacuum and the innermost (sample) chamber is held at cryogenic temperature to cool wafer or thin film samples through gaseous thermal transfer media to cryogenic temperatures down to 1.9 K under pumping. To achieve full-range wafer mapping, the measurement and sensing components for transmitted and reflected light, including infrared probing beam sources, such as long-wavelength infrared lasers, fast HgCdTe detectors, or detector liner or 2-dimensional arrays mounted in liquid nitrogen dewars or thermoelectric (TE)-cooled detector housings, excitation lasers with a wavelength shorter than the bandgap of the sample to be measured, a broadband infrared source with focusing mirror, light grating with mirror and its other accessories including the motion execution and control components, and a linear LWIR array in a liquid nitrogen Dewar, are positioned outside all three chambers and can be moved through a carriage mounting to create the radial component of the mapping motion domain. The rotation of the sample holder is controlled through a drive gear located inside the sample chamber and creates the angular component of the mapping motion domain. |
| FILED | Thursday, May 04, 2023 |
| APPL NO | 18/143257 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/42 (20130101) G01N 21/9505 (20130101) Original (OR) Class G01N 2201/103 (20130101) G01N 2201/0636 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201151 | Di Benedetto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mission Support and Test Services, LLC (Las Vegas, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Di Benedetto (Santa Barbara, California); Ken Moy (Santa Barbara, California) |
| ABSTRACT | A sensor with a built in calibration gas source having an outer housing configured to contain one or more of the sensor elements. Within the housing is a controller configured to manage operation of the sensor and a user interface configured with one or more user input elements and one or more sensor output elements. A detector module has one or more detectors, configured to sense a calibration gas and, responsive to detection of the calibration gas, provide a detection signal to the controller. A calibration module configured to, responsive to a control signal from the controller, generate a calibration gas and present the calibration gas in proximity to one or more of the detectors. A power source is also provided and configured to provide power to the controller, the detector module, and the calibration module. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/595167 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201179 | Kuru et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Erkin Kuru (Cambridge, Massachusetts); George M. Church (Cambridge, Massachusetts); Janathan Rittichier (Cambridge, Massachusetts); Isaac Han (Cambridge, Massachusetts); Helena de Puig Guixe (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are fluorogenic sensors which can be used to detect targets (e.g., antigens). In general, the fluorogenic sensors provided herein comprise a protein (e.g., antibody, nanobody, mini-protein) and a fluorogenic small molecule conjugated to the target-binding domain (e.g., antigen-binding domain) of the protein. Upon binding of the protein to said target (e.g., antigen), the fluorogenic small molecule may increase or decrease in fluorescence or exhibit a change in fluorescence lifetime (i.e., “turn on”), thereby indicating the presence of the target (e.g., antigen). |
| FILED | Friday, March 25, 2022 |
| APPL NO | 18/282991 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 251/30 (20130101) Heterocyclic Compounds C07D 207/273 (20130101) C07D 207/337 (20130101) C07D 471/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6408 (20130101) G01N 21/6428 (20130101) G01N 33/58 (20130101) G01N 33/54373 (20130101) Original (OR) Class G01N 33/56911 (20130101) G01N 33/56983 (20130101) G01N 2021/6439 (20130101) G01N 2333/34 (20130101) G01N 2333/165 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201277 | Tong |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shijie Tong (San Diego, California) |
| ABSTRACT | A system, a method, and a computer program product for providing heterogeneous unifying battery storage. A state-of-health value of a battery is determined. The state-of-health value of the battery is less than an original capacity value of the battery. The battery is connected to an electrical power source for re-conditioning. A target state-of-health value for the battery and a number of cycles required to achieve the target state-of-health value of the battery are determined. Each cycle in the number of cycles includes at least one of: a charging the battery and a discharging the battery. The battery is re-conditioned by cycling the battery using the determined number of cycles. Cycling includes drawing electrical power from the electrical power source. |
| FILED | Tuesday, November 21, 2023 |
| APPL NO | 18/516886 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/392 (20190101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0069 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202899 | Yellowhair |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julius Yellowhair (Albuquerque, New Mexico) |
| ABSTRACT | A system or method for an imaging system is provided for inspecting a heliostat. The imaging system includes a platform and a camera mounted on the platform and a heliostat having one or more mirrored facets. The camera is positioned to acquire a first image that serves as a reference image and a second image that is a reflected image from at least one facet. The camera stores image data associated with the first image and the second image, and wirelessly transmits the stored image data to a computing apparatus. The computing apparatus compares the first image with the second image and determines a performance parameter associated with the heliostat. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/586839 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 11/02 (20130101) Image Data Processing or Generation, in General G06T 7/0002 (20130101) Original (OR) Class G06T 2207/10016 (20130101) G06T 2207/10032 (20130101) Pictorial Communication, e.g Television H04N 5/265 (20130101) H04N 7/183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240203636 | Kautz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Kautz (Shawnee, Kansas); Marcus Kautz (Arvada, Colorado); David Allendorfer (Olathe, Kansas); Jeremy Sims (Pleasant Hill, Missouri) |
| ABSTRACT | Systems, methods, and devices are provided for producing and using a low-value inductor which is stable at high frequencies, the inductor including a plurality of radial spokes extending between two concentric rings. The inductance of the inductor is controlled by the number and dimensions of the plurality of spokes, as well as the materials of the inductor. In some cases, the inductor is used as a low value inductance standard for directly measuring a low value electrical inductance. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/430942 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 5/00 (20130101) H01F 27/28 (20130101) Original (OR) Class H01F 27/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204128 | Shao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qinghui Shao (Fremont, California); Lars F. Voss (Livermore, California); Soroush Ghandiparsi (Pleasant Hill, California) |
| ABSTRACT | Devices, methods and techniques related to high voltage and high-power diamond transistors are disclosed. In one example aspect, a switch operable under high-voltage and high-power includes a P-type diamond layer doped with an acceptor material and an N-type diamond region doped with a donor material. The P-type diamond layer is at least partially embedded the N-type diamond region. The switch includes a layer comprising one or more apertures configured to allow illumination from a light source to pass through to reach the N-type diamond region, a source contact and a drain contact that are at least partially in contact with the P-type diamond layer; and a gate in contact with at least an area of the N-type diamond region. |
| FILED | Wednesday, January 31, 2024 |
| APPL NO | 18/428200 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/028 (20130101) H01L 31/1126 (20130101) Original (OR) Class H01L 31/02161 (20130101) H01L 31/02164 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204129 | LUTHER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Tandem PV, Inc. (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Matthew LUTHER (Boulder, Colorado); Kyle James REITER (Denver, Colorado); Rosemary Claire BRAMANTE (Lakewood, Colorado); Colin David BAILIE (Morgan Hill, California); Chris EBERSPACHER (Palo Alto, California); Timothy Sean GEHAN (Mountain View, California); David Cale MALONEY (Commerce City, Colorado); Marinus Franciscus Antonius Maria VAN HEST (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to a photovoltaic device that includes a first contact layer having a first thickness, a first charge transport layer (CTL) having a second thickness positioned over a surface of the first contact layer, an absorber layer having a third thickness positioned over a surface of the first CTL, a second CTL having a fourth thickness positioned over a surface of the absorber layer, a second contact layer having fifth thickness positioned over a surface of the second CTL, a barrier layer having a sixth thickness, an encapsulation layer, and a first scribe line defined by at least one surface. Further, at least a portion of the barrier layer is positioned between the encapsulation layer and the second CTL, the at least one surface of the scribe line comprises at least a portion of the third thickness, fourth thickness, fifth thickness, and/or at least a portion of the second thickness, and the barrier layer is disposed over at least a portion of the at least one surface formed by the first scribe line. |
| FILED | Wednesday, November 29, 2023 |
| APPL NO | 18/523000 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/05 (20130101) H01L 31/048 (20130101) H01L 31/1868 (20130101) Original (OR) Class Organic electric solid-state devices H10K 30/40 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204200 | Archer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lynden A. Archer (Ithaca, New York); Jingxu Zheng (Shenzhen, China PRC) |
| ABSTRACT | Anodes and anode materials, methods of making anodes and anode materials, and devices. The anode and anode materials comprise an electrically conducting three-dimensional (3-D) matrix, for example, an electrically conducting 3-D carbon matrix or a metal foam, comprising a plurality of chemical bonding groups disposed on a surface of the electrically conducting 3-D matrix or metal foam. The chemical bonding groups can form chemical bond(s) with an electrochemically-deposited electrochemically active metal. The electrochemically-deposited electrochemically active metal can have desirable propert(ies), such as, for example, no observable discontinuities, isolated (orphaned) deposits, or both. An anode or anode material may be formed by functionalizing an electrically conducting 3-D matrix, which may be functionalized. A functionalized electrically conducting 3-D matrix may be formed in a device. A device, such as, for example,. a battery, a supercapacitor, a fuel cell, an electrolyzer, or an electrolytic cell, comprises one or more anode(s) or anode material(s). |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 18/550622 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0404 (20130101) H01M 4/663 (20130101) Original (OR) Class H01M 10/05 (20130101) H01M 10/4207 (20130101) H01M 2004/021 (20130101) H01M 2004/027 (20130101) H01M 2010/4292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204242 | Gonzalez Malabet et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Hernando Gonzalez Malabet (Farmington Hills, Michigan); Thomas A. Yersak (Royal Oak, Michigan); Aaron Ketchum (Sterling Heights, Michigan) |
| ABSTRACT | A removable binder system to expand application of hot-pressed solid-state electrolyte separator technology is provided, specifically a solid-state electrolyte (SSE) for an electrochemical cell, a method for producing an electrochemical cell and an electrode composite film for an electrochemical cell in order to provide separators that work well with binders such that removing the binders does not affect the electro-molecular properties of the separators. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/080864 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2004/027 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204276 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianlin Li (Oak Ridge, Tennessee); Mengya Li (Oak Ridge, Tennessee); William B. Hawley (Oak Ridge, Tennessee) |
| ABSTRACT | A method of upcycling cathode active materials is provided. The method includes mixing two or more precursor materials at ambient temperature to form a first eutectic mixture. The method further includes mixing a cathode active material with the first eutectic mixture to form a second eutectic mixture. The method further includes subjecting the second eutectic mixture to a two-step calcination process. The two-step calcination process includes first calcining the second eutectic mixture at a first temperature for a first period of time to obtain an intermediate material and second, calcining the intermediate material at a second temperature for a second period of time to obtain an upcycled cathode active material. The second temperature is higher than the first temperature, and the upcycled cathode active material has a composition that is different than a composition of the cathode active material. A cathode active material formed by the method is also provided. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/536523 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/42 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204587 | Kuczek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HAMILTON SUNDSTRAND CORPORATION (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrzej E. Kuczek (Bristol, Connecticut); Jagadeesh K. Tangudu (South Windsor, Connecticut); Kimberly R. Saviers (Glastonbury, Connecticut); Joseph E. Turney (Amston, Connecticut); Abbas A. Alahyari (Glastonbury, Connecticut) |
| ABSTRACT | Stators for aircraft electric motors include a cantilever structure having a supported end and an unsupported end, wherein the cantilever structure includes an inlet support manifold and an outlet support manifold arranged at the supported end and a plurality of cooling plates extending from the inlet support manifold and the outlet support manifold to the unsupported end. A plurality of coils are arranged between and in thermal contact with the cooling plates and a core passes through the plurality of coils and the plurality of cooling plates. Each cooling plate defines a cooling channel that fluidly couples the inlet support manifold and the outlet support manifold, and the coils and the core are structurally supported by the plurality of cooling plates in a cantilevered manner at the supported end. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/081010 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 33/08 (20130101) B64D 2221/00 (20130101) Dynamo-electric Machines H02K 1/20 (20130101) Original (OR) Class H02K 9/19 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204783 | Tzimpragos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Georgios Tzimpragos (San Jose, California); Dilip Vasudevan (Emeryville, California); Nestan Tsiskaridze (Santa Barbara, California); Georgios Michelogiannakis (Berkeley, California); Advait Madhavan (Gaithersburg, Maryland); Jennifer Volk (Santa Barbara, California); John Shalf (Oakland, California); Timothy Sherwood (Goleta, California) |
| ABSTRACT | A primitive race-logic temporal operator is described, comprising superconducting logic single flux quantum (SFQ) cells. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/909932 |
| CURRENT CPC | Pulse Technique H03K 3/037 (20130101) H03K 19/20 (20130101) H03K 19/195 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240206221 | Horowitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. Horowitz (Ann Arbor, Michigan); Claire Arneson (Ann Arbor, Michigan); Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | In one aspect, an organic light emitting device (OLED) comprises a first electrode, a second electrode, an emissive layer between the first and second electrodes, and a blocking layer comprising metal oxide between the emissive layer and the first electrode. In some embodiments, the OLED is configured as a white OLED. In some embodiments, the emissive layer comprises a stack of a plurality of sub-layers. In some embodiments, the blocking layer is deposited via an atomic layer deposition (ALD) tool. In some embodiments, the blocking layer comprises HfO2, Al2O3, ZrO2, ZnO, or MgO. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/539591 |
| CURRENT CPC | Organic electric solid-state devices H10K 50/13 (20230201) H10K 50/18 (20230201) Original (OR) Class H10K 2102/351 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240197635 | Godfrin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VeraMorph LLC (Mansfield, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Douglas Godfrin (Quincy, Massachusetts) |
| ABSTRACT | The present disclosure relates to the composition and methods of manufacturing and use of dissociating polymeric matrix oral dosages (disintegrating pre-formed oral dosage hydrogels) loaded with fulvestrant as an orally delivered therapy for the treatment of diseases, particularly cancer and especially metastatic breast cancer. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/548816 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/146 (20130101) Original (OR) Class A61K 31/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197702 | WARNER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Lousiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isiah Manuel WARNER (Baton Rouge, Louisiana); Jeffrey Andre HOBDEN (Baton Rouge, Louisiana); Kelsey Marie LOPEZ (Baton Rouge, Louisiana) |
| ABSTRACT | Ion-pairs known as GUMBOS (group of uniform materials based on organic salts) from antiseptics (chlorhexidine and octenidine) and the beta-lactam antibiotic, ceftriaxone. The antimicrobial efficacy of these GUMBOS and unreacted stoichiometric equivalent mixtures were compared to ceftriaxone and azithromycin alone. On a molar basis, GUMBOS were equivalent to ceftriaxone and 10× more effective in killing N. gonorrhoeae than azithromycin. They were more than 100× more effective than either antibiotic in killing CRE. A strategy involving the electrostatic interaction between a common antiseptic and a discontinued antibiotic (octenidine and carbenicillin) was also evaluated as a treatment for gonorrhoea. Octenidine/carbenicillin is a novel group of uniform materials based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antiseptic and antibacterial ions, octenidine and carbenicillin, respectively. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/909869 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/43 (20130101) A61K 31/444 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197886 | Lyons et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York); SingletO2 Therapeutics LLC (New Providence, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan M. Lyons (New Providence, New Jersey); Alexander Greer (New York, New York); QianFeng Xu (Staten Island, New York) |
| ABSTRACT | A device for generating singlet oxygen is provided. The device has a sensitizer that converts triplet oxygen to singlet oxygen upon exposure to light. The device is configured to keep the sensitizer from contacting external fluids. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594359 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0057 (20130101) Original (OR) Class Separation B01D 69/02 (20130101) B01D 71/26 (20130101) B01D 2325/38 (20130101) B01D 2325/0283 (20220801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197934 | Xie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xing Xie (Atlanta, Georgia); Feifei Liu (Atlanta, Georgia); Ting Wang (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a system for microorganism and/or biofilm inactivation that can comprise an antimicrobial surface. The antimicrobial surface can comprise a plurality of electrodes arranged in a predetermined pattern. The antimicrobial surface can include an insulative material which can coat at least a portion of each of the plurality of electrodes. The antimicrobial surface can include an external power source that can be configured to supply electrical power to the plurality of electrodes to at least in part induce the electric field via the plurality of electrodes. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/540223 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/03 (20130101) Original (OR) Class A61L 2/24 (20130101) A61L 2/26 (20130101) A61L 2202/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198337 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weiqiang Chen (New York, New York); Chao Ma (New York, New York) |
| ABSTRACT | The present invention provides devices that replicate bone marrow niche in a microfluidic chip. The devices can be used to model certain disease states related to bone marrow, such as leukemic bone marrow niche remission and relapse under various treatment conditions. The devices can be adapted to replicate bone marrow niche from patient-specific cells such that treatment conditions can be modeled and tailored to individual patients. In some embodiments, the devices are suitable for evaluating leukemia therapies on a patient-specific basis. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/555363 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/16 (20130101) B01L 2300/0816 (20130101) B01L 2400/086 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198340 | Anand et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robbyn K. Anand (Ames, Iowa); Sungu Kim (Ames, Iowa); Baskar Ganapathysubramanian (Ames, Iowa) |
| ABSTRACT | Microfluidic devices and methods that utilize ion concentration polarization within nanoliter scale droplets for concentration enrichment, separation, and substitution of charges species are disclosed. Such devices and methods can be used for separation of multiple species by mobility of each species and for the alteration and manipulation of the droplet composition by ion exchange. |
| FILED | Wednesday, January 17, 2024 |
| APPL NO | 18/415200 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 3/502784 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/047 (20130101) B01L 2300/0645 (20130101) B01L 2300/0864 (20130101) B01L 2400/0421 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198363 | Sethi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sunny Sethi (Castro Valley, California); Nicholas James McKibben (Oakland, California); Grant Harrison Friesen (Concord, California); Sagar Bhatia (Fremont, California) |
| ASSIGNEE(S) | HEN NOZZLES INC. (Hayward, California) |
| INVENTOR(S) | Sunny Sethi (Castro Valley, California); Nicholas James McKibben (Oakland, California); Grant Harrison Friesen (Concord, California); Sagar Bhatia (Fremont, California) |
| ABSTRACT | A nozzle including a nozzle body having a flow path therein, the nozzle further including a face plate coupled to or positioned in the nozzle body and having an engagement surface. The nozzle includes an arm coupled to or positioned in the nozzle body, the arm including an engagement surface engaging the engagement surface of the face plate. At least one of the engagement surface of the face plate or the engagement surface of the arm has at least part of a spherical surface. The face plate and the arm are configured such that relative rotation between the face plate and the nozzle body causes at least part of the arm to move toward or away from a center of the flow path. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390659 |
| CURRENT CPC | Fire-fighting A62C 31/03 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/12 (20130101) Original (OR) Class B05B 1/044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199664 | Mirica et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); The Regents of the University of California (Oalkland, California) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire); The Regents of The University Of California (Oakland, California) |
| INVENTOR(S) | Katherine A. Mirica (Hanover, New Hampshire); Aylin Aykanat (Lyme, New Hampshire); Evan Cline (Lebanon, New Hampshire); Zheng Meng (West Lebanon, New Hampshire); Christopher G. Jones (Los Angeles, Canada); Hosea Nelson (Venice, California) |
| ABSTRACT | Embodiments of the present disclosure pertain to compositions that include a metal-organic framework. The metal-organic framework includes a plurality of metals and a plurality of ligands coordinated with the plurality of metals, where the plurality of metals include bismuth, and the plurality of ligands include a plurality of hydroxy moieties that are not part of carboxyl groups. At least some of the hydroxy moieties are coordinated with bismuth to form Bi—O bonds. The metal-organic framework is in the form of a conductive and interconnected network. Additional embodiments of the present disclosure pertain to methods of utilizing the compositions to detect analytes in a sample and shield various objects from radiation. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 18/286796 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/107 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/94 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 31/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199696 | Hudalla et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Gregory Allan Hudalla (Gainesville, Florida); Renjie Liu (Gainesville, Florida) |
| ABSTRACT | Provided herein are co-assembling peptides which may form particles (e.g., nanoparticles or granules) under stimulating conditions. Also provided herein are protein carrying particles (e.g., nanoparticles or granules). Further provided herein, are methods of making each of the co-assembling peptides and particles (e.g., nanoparticles or granules). |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 18/287368 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/42 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 7/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0069 (20130101) Enzymes C12Y 113/12007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199704 | FOX et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerome FOX (Boulder, Colorado); Ankur SARKAR (Boulder, Colorado); Akarawin HONGDUSIT (Boulder, Colorado); Edward KIM (Oakland, California) |
| ABSTRACT | This invention relates to the field of genetic engineering. Specifically, the invention relates to the construction of operons to produce biologically active agents. For example, operons may be constructed to produce agents that control the function of biochemical pathway proteins (e.g., protein phosphatases, kinases and/or proteases). Such agents may include inhibitors and modulators that may be used in studying or controlling phosphatase function associated with abnormalities in a phosphatase pathway or expression level. Fusion proteins, such as light activated protein phosphatases, may be genetically encoded and expressed as photoswitchable phosphatases. Systems are provided for use in controlling phosphatase function within living cells or in identifying small molecule inhibitors/activator/modulator molecules of protein phosphatases associated with cell signaling. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/443086 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/47 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Enzymes C12Y 205/0101 (20130101) C12Y 205/01001 (20130101) C12Y 207/01036 (20130101) C12Y 207/04002 (20130101) C12Y 301/01048 (20130101) C12Y 401/01033 (20130101) C12Y 402/03017 (20130101) C12Y 402/03018 (20130101) C12Y 402/03024 (20130101) C12Y 402/03056 (20130101) C12Y 503/03002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199882 | Scott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colleen N. Scott (Starkville, Mississippi); Chathuranga S. L. Rathnamalala (Frederick, Maryland) |
| ASSIGNEE(S) | Mississippi State University (Starkville, Mississippi) |
| INVENTOR(S) | Colleen N. Scott (Starkville, Mississippi); Chathuranga S. L. Rathnamalala (Frederick, Maryland) |
| ABSTRACT | A near infrared dye comprising a counterion and a structure of Formula I wherein the at least one of R1 and R2 are selected from dibenzazepinyl, thienyldibenzazepine, bithienyldibenzazepine, thienodibenzazepine, dihydrodibenzazepinyl, thienyldihydrodibenzazepine, bithienyldihydrodibenzazepine, and thienodihydrodibenzazepine, and X, R, R3-R4, R19, R20 and R22-R29 are as disclosed herein. Materials and compositions comprising the SWIR dye can absorb light at a wavelength of 800 nm to 1400 nm and release the energy in the form of light (fluorescence) or heat (non-radiative). The dyes can also convert the absorbed light to heat and ultrasound waves via the photoacoustic effect. The photoacoustic effect can be used in photoacoustic tomography to image biological materials or processes. Methods for synthesizing the SWIR dyes and materials comprising the same are also disclosed. |
| FILED | Thursday, November 30, 2023 |
| APPL NO | 18/524289 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 49/126 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 2001/302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200026 | Sozzani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosangela Sozzani (Raleigh, North Carolina); Timothy J. Horn (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides materials and methods relating to bioprinting. In particular, the present disclosure provides compositions, systems, and methods for 3D bioprinting plant cells according to pre-determined spatiotemporal patterns to facilitate the high-throughput regeneration of plants having reduced variability. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/907076 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/04 (20130101) Original (OR) Class C12N 2501/10 (20130101) C12N 2501/30 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200050 | VAN DEVENTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts) |
| INVENTOR(S) | James A. VAN DEVENTER (Medford, Massachusetts); Jessica T. STIEGLITZ (Medford, Massachusetts) |
| ABSTRACT | The invention provides aminoacyl-tRNA synthetases, compositions thereof, and methods for use thereof. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/513092 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/66 (20130101) Enzymes C12Y 601/01001 (20130101) C12Y 601/01004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200051 | Diviesti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COLORADO SCHOOL OF MINES (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karla Diviesti (Golden, Colorado); Richard C. Holz (Golden, Colorado) |
| ABSTRACT | Disclosed herein are compositions, methods, and systems useful in remediating contaminants, for example environmental contaminants. In many embodiments, the contaminant is selected from atrazine and chlorothalonil, and the remediation is accomplished with a biomaterial. In many embodiments, the biomaterial comprises an enzyme that catalyzes the contaminant remediation and a gel, for example a biogel or sol-gel. In some embodiments, the enzyme is triazine hydrolase (TrzN) for example TrzN from Arthrobacter aurescens TC1. The gel may be in the form of beads, for example alginate beads, and the beads may be coated, for example in chitosan. The disclosed sol-gel may be comprised of tetramethylorthosilicate (TMOS). The disclosed compositions, methods, and systems may increase enzymatic activity and/or protect the enzyme from activity degradation due to pH, temperature, proteolysis, dehydration, etc. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/544148 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/342 (20130101) C02F 2101/38 (20130101) C02F 2103/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) C12N 11/04 (20130101) Original (OR) Class C12N 11/10 (20130101) Enzymes C12Y 308/01008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200056 | Barbieri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Barbieri (Lindenhurst, New York); Farren Isaacs (Stamford, Connecticut) |
| ABSTRACT | Compositions and methods for gene editing are provided. The methods employ an oligo-based annealing mechanism that is rooted in the process of DNA replication rather than homologous recombination (HR). Oligo incorporation efficiencies are comparable and often exceed those of CRISPR/cas9 editing without the need for double strand breaks (DSBs). By relying on the multiplex annealing of oligos rather than DSBs the process is highly scalable across a genomic region of interest and can generate many scarless modifications of a chromosome simultaneously. Combinatorial genomic diversity can be generated across a population of cells in a single transformation event; genomic landscapes can be traversed through successive iterations of the process, and genome-wide changes can be massively parallelized and amplified through systematic strain mating. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/340687 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) C12N 15/1058 (20130101) Original (OR) Class C12N 15/1079 (20130101) C12N 15/1082 (20130101) C12N 15/1086 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2525/185 (20130101) C12Q 2543/10 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/06 (20130101) C40B 40/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200103 | ALEXANDER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Gerald ALEXANDER (Madison, Wisconsin); David Peris NAVARRO (Madison, Wisconsin); Christopher Todd HITTINGER (Madison, Wisconsin) |
| ABSTRACT | Methods of making synthetic yeast cells by mating together two diploid (or higher ploidy) yeast species or hybrids to generate multiploid yeast hybrids are provided herein. The synthetic yeast cells made by this process and kits for performing the process are also provided. |
| FILED | Friday, January 19, 2024 |
| APPL NO | 18/417305 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/18 (20130101) C12N 9/16 (20130101) C12N 15/65 (20130101) C12N 15/81 (20130101) C12N 15/905 (20130101) Original (OR) Class C12N 2800/80 (20130101) C12N 2840/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200203 | Choi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyoung-Shin Choi (Fitchburg, Wisconsin); Dohwan Nam (Madison, Wisconsin); Ryan Belson (Madison, Wisconsin) |
| ABSTRACT | Electrochemical systems and methods for removing and recovering phosphorus, in the form of phosphates, from aqueous solutions are provided. The removal of the phosphates takes place in an electrochemical cell having an electrode that includes bismuth (Bi), zinc (Zn), copper (Cu), iron (Fe), or an oxide thereof. During the removal of phosphates from aqueous solution, the metal (Bi, Zn, Cu, or Fe) and/or metal oxide of the electrode is converted into its corresponding metal phosphate within the electrode via a reversible conversion reaction. The phosphate stored in the electrode during the removal step is subsequently released into a recovery solution via electrochemical reduction of the metal phosphate back into a metal. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066474 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/01 (20210101) Original (OR) Class C25B 9/17 (20210101) C25B 11/042 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200234 | Flamini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rowan University (Glassboro, New Jersey) |
| ASSIGNEE(S) | Rowan University (Glassboro, New Jersey) |
| INVENTOR(S) | Matthew Flamini (Mullica Hill, New Jersey); Vince Beachley (Medford Lakes, New Jersey) |
| ABSTRACT | In one aspect, the present disclosure is related to system and method of manufacturing nanomaterials and particularly to system and method for zone-drawing and/or zone-annealing fibers. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 18/557099 |
| CURRENT CPC | Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/22 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200237 | Sarabia-Riquelme et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruben Sarabia-Riquelme (Lexington, Kentucky); Matthew C. Weisenberger (Lawrenceburg, Kentucky) |
| ABSTRACT | A method for making electrically-conductive yarn includes simultaneously drawing and axially twisting a starting material selected from a group consisting of intrinsically electrically-conducting fiber nonwovens and multifilament tows of intrinsically electrically-conducting fiber. The resulting yarn is a compacted, intrinsically electrically-conducting fiber material having an axial twist of between about 0.5 and about 60 degrees. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/540795 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/06 (20130101) Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/26 (20130101) D02G 3/045 (20130101) D02G 3/441 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2321/12 (20130101) D10B 2401/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201065 | Gamez |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | Texas Tech University System (Lubbock, Texas) |
| INVENTOR(S) | Gerardo Gamez (Lubbock, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of identifying one or more characteristics of particles by (1) placing the particles on a surface; (2) exposing the particles to an ion to result in emissions from the particles; (3) measuring the emissions from the particles; (4) generating an emission profile from the measured emissions; and (5) correlating the generated emission profile to one or more characteristics of the particles |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541426 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/02 (20130101) G01N 15/1429 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201084 | Ünlü et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Selim Ünlü (Newton, Massachusetts); Iris Celebi (Allston, Massachusetts); Mete Aslan (Brighton, Massachusetts) |
| ABSTRACT | Aspects of inventive concepts described herein relate to an interferometric reflectance imaging system. The system can include an imaging sensor including pixels that are preferentially sensitive to a plurality of light components; an illumination source configured to emit illumination light along an illumination path, the illumination light including the plurality of light components; and a target including a target substrate configured to support one or more nanoparticles on a surface of the target substrate. The system may be configured to, at a nominal focus position: generate an image at the imaging sensor based, at least in part, on the light reflected from the target interfering with light scattered from nanoparticles on the target substrate; and process the image to detect the nanoparticles on the target substrate. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/544361 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02011 (20130101) G01B 9/02041 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) G01N 21/45 (20130101) Original (OR) Class G01N 21/55 (20130101) G01N 2201/06153 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201280 | ABU QAHOUQ |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaber A. ABU QAHOUQ (Tuscaloosa, Albania) |
| ABSTRACT | Systems and method for determining State-of-Health (SOH) for energy storage devices are described herein. An example method includes measuring a complex impedance of an energy storage device for a range of frequency, and estimating a state of health (SOH) of the energy storage device based on an interrelationship between a magnitude and a phase of the complex impedance of the energy storage device. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 18/556769 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/389 (20190101) G01R 31/392 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201563 | Ledezma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Luis M. Ledezma (La Crescenta, California); Alireza Marandi (Pasadena, California); Robert M. Gray (Pasadena, California); Benjamin K. Gutierrez (Redondo Beach, California) |
| ABSTRACT | On-chip generation of coherent radiation, i.e. laser-like radiation, can be tuned over broad and/or hard-to-access wavelength regions in an integrated platform. Target spectral coverage is beyond what could be achieved with existing integrated laser systems. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/543950 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/39 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/50 (20130101) H01S 5/125 (20130101) H01S 5/141 (20130101) H01S 5/0265 (20130101) H01S 5/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202435 | BAJAJ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio); University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Goonmeet Kaur BAJAJ (Columbus, Ohio); Srinivasan Parthasarathy (Columbus, Ohio); Amit Sheth (Columbia, South Carolina); Ugur Kursuncu (Columbia, South Carolina) |
| ABSTRACT | In an embodiment, a set of related documents (105) is selected (305). Each document may include at least one table of data (107). The tables may not include semantic or structural data that can be used to understand the data in the tables. Each table is processed to determine a schema for the table that includes a name and type for each column of the table (320). A consolidated schema is received for a consolidated table (320). The consolidated schema includes a name and type for each column of the consolidated table. The data from each table is extracted from the table and added to the consolidated table based on the schema associated with the table and the schema associated with the consolidated table (325). Later, the data in the consolidated table can be visualized to help identify one or more trends (400). |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/555605 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/177 (20200101) Original (OR) Class G06F 40/194 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240203151 | CARNEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan M. CARNEY (Temple Terrace, Florida); Sriram CHELLAPPAN (Tampa, Florida) |
| ABSTRACT | Images of an insect larva are subjected to at least a first convolutional neural network to develop feature maps based on anatomical pixels at corresponding image locations in the respective feature maps. The anatomical pixels correspond to a body part of the insect larva. A computer uses a plurality of feature maps form an integrated feature map and bounding boxes on anatomical pixels corresponding to a head, thorax, abdomen, or terminal abdomen area of the insect larva. A classification network identifies the genus, the species, the sex, or the life stage of the insect larva. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/553688 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/82 (20220101) G06V 10/94 (20220101) G06V 10/225 (20220101) G06V 10/764 (20220101) G06V 10/7715 (20220101) G06V 40/10 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240203590 | KOTZ et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DAVID KOTZ (Lyme, New Hampshire); SHENGJIE BI (WHITE RIVER JUNCTION, Vermont) |
| ABSTRACT | A method of detecting health-related behaviors, comprising training a model with video of the mouths of one or more users, capturing video using a camera focused on a user's mouth; processing the video using the model; and outputting one or more health-related behaviors detected in the captured video by the model. A method of training the model includes preprocessing a video captured by a camera focused on a user's mouth by extracting raw video frames and optical flow features; classifying the video frame-by-frame; aggregating video frames in sections based on their classifications; and training the model using the classified and aggregated video frames. A wearable device for capturing video of a user's mouth is also described. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 18/287428 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/764 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240203669 | Nguyen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Clark T.-C. Nguyen (Oakland, California); Qiutong Jin (Albany, California); Kevin Zheng (Berkeley, California) |
| ABSTRACT | A micromechanical resoswitch design and operation mode harnesses stored mechanical resonance energy to reduce its required switching energy and improve achievable bit rate in the example to 8 kbps, which is at least 12 times faster than without pre-energization. The use of stored energy is instrumental to achieving switching times 8 times faster than previously demonstrated, breaking the Q-driven sensitivity-bit rate tradeoff often assumed for these devices and overcoming long-held (incorrect) assumptions. The resoswitch adapts to the required bit rate, adjusting its switching time to accommodate a fast or slow rate, greatly expanding the application space. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/531505 |
| CURRENT CPC | Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 1/0036 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240203720 | Laskin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julia Laskin (West Lafayette, Indiana); Pei Su (West Lafayette, Indiana); Carlos Larriba (Indianapolis, Indiana); Xi Chen (Indianapolis, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for systems and methods for multiplexed electrospray ionization. In certain embodiments, electrospray ionization sources orthogonally inject ions into an ion funnel with at least two of the sources injecting on the same side of the ion funnel. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/287357 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/066 (20130101) Original (OR) Class H01J 49/107 (20130101) H01J 49/165 (20130101) H01J 49/0468 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204385 | Friedman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Amherst College (Amherst, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan R. Friedman (Amherst, Massachusetts) |
| ABSTRACT | Improved loop-gap resonators applicable to Electron-Spin Resonance spectroscopy and to quantum computing employ interdigitated capacitor structures to dramatically increase the capacitance of the resonator, along with corresponding decreases in loop size to enable measurements of small-volume samples or individual quantum bits (qubits). The interdigitated-capacitor structures are designed to minimize parasitic inductance. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/590510 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/60 (20130101) G01R 33/343 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/06 (20130101) Original (OR) Class H01P 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204783 | Tzimpragos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Georgios Tzimpragos (San Jose, California); Dilip Vasudevan (Emeryville, California); Nestan Tsiskaridze (Santa Barbara, California); Georgios Michelogiannakis (Berkeley, California); Advait Madhavan (Gaithersburg, Maryland); Jennifer Volk (Santa Barbara, California); John Shalf (Oakland, California); Timothy Sherwood (Goleta, California) |
| ABSTRACT | A primitive race-logic temporal operator is described, comprising superconducting logic single flux quantum (SFQ) cells. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/909932 |
| CURRENT CPC | Pulse Technique H03K 3/037 (20130101) H03K 19/20 (20130101) H03K 19/195 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240205083 | Yeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edmund Meng Yeh (Newton, Massachusetts); Khashayar Kamran (Allston, Massachusetts) |
| ABSTRACT | A framework for joint computation, caching, and request forwarding in data-centric computing-based networks comprises a virtual control plane, which operates on request counters for computations and data, and an actual plane, which handles computation requests, data requests, data objects and computation results in the physical network. A throughput optimal policy, implemented in the virtual plane, provides a basis for adaptive and distributed computation, caching, and request forwarding in the actual plane. The framework provides superior performance in terms of request satisfaction delay as compared with several baseline policies over multiple network topologies. |
| FILED | Thursday, February 29, 2024 |
| APPL NO | 18/591973 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/547 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/082 (20130101) Original (OR) Class H04L 67/10 (20130101) H04L 67/568 (20220501) H04L 69/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240197702 | WARNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Lousiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isiah Manuel WARNER (Baton Rouge, Louisiana); Jeffrey Andre HOBDEN (Baton Rouge, Louisiana); Kelsey Marie LOPEZ (Baton Rouge, Louisiana) |
| ABSTRACT | Ion-pairs known as GUMBOS (group of uniform materials based on organic salts) from antiseptics (chlorhexidine and octenidine) and the beta-lactam antibiotic, ceftriaxone. The antimicrobial efficacy of these GUMBOS and unreacted stoichiometric equivalent mixtures were compared to ceftriaxone and azithromycin alone. On a molar basis, GUMBOS were equivalent to ceftriaxone and 10× more effective in killing N. gonorrhoeae than azithromycin. They were more than 100× more effective than either antibiotic in killing CRE. A strategy involving the electrostatic interaction between a common antiseptic and a discontinued antibiotic (octenidine and carbenicillin) was also evaluated as a treatment for gonorrhoea. Octenidine/carbenicillin is a novel group of uniform materials based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antiseptic and antibacterial ions, octenidine and carbenicillin, respectively. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/909869 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/43 (20130101) A61K 31/444 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240198317 | KANAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew W. KANAN (Palo Alto, California); Amy Delano FRANKHOUSER (Oakland, California); Chastity S. LEE (Palo Alto, California) |
| ABSTRACT | A catalyst for performing the reverse-water-gas-shift (RWGS) reaction is provided comprising an alkali carbonate dispersed on a porous support. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 18/555826 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/04 (20130101) Original (OR) Class B01J 35/80 (20240101) Non-metallic Elements; Compounds Thereof; C01B 32/40 (20170801) Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide C10K 3/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240200875 | Hobbs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Blue Origin, LLC (Kent, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gavin Bradley Hobbs (Maple Valley, Washington); Patrick James Daniels (Poulsbo, Washington); Kip Alan Carver (Mountlake Terrace, Washington); Wooyong Jung (Mukilteo, Washington) |
| ABSTRACT | A heat exchange system includes cooling tubes that carry coolant and are placed on an external surface of a storage tank, which may be spherical, cylindrical, or other shape. The storage tank may be a cryogenic rocket fuel tank. The cooling tubes are bent to particular radius of curvatures that correspond to the varying curvatures of the storage tank. A network of spacers and bridge brackets with adjustable setscrews are used to precisely place the cooling tubes in correct positions on the external surface of the storage tank. Once placed in the desired position, the setscrews are adjusted to maximize the surface area contact between the cooling tubes and the exterior surface of the storage tank, resulting in optimal heat transfer without overstressing the materials of the tubing or the storage tank. The precisely positioned tubes may then be permanently affixed to the exterior surface of the storage tank using a cryogenic adhesive. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/069080 |
| CURRENT CPC | Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 13/001 (20130101) F17C 13/008 (20130101) F17C 2201/0128 (20130101) F17C 2203/0362 (20130101) F17C 2221/011 (20130101) F17C 2221/012 (20130101) F17C 2260/031 (20130101) F17C 2270/0197 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 1/06 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2240/00 (20130101) F28F 2275/16 (20130101) F28F 2275/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201365 | MOGHADDAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Mahta MOGHADDAM (Rolling Hills Estates, California); Yuan FANG (Los Angeles, California); Kazem BAKIAN-DOGAHEH (Los Angeles, California) |
| ABSTRACT | A microwave imaging (MWI) system prototype to reconstruct three-dimensional (3D) complex dielectric images of various dielectric phantom models is provided. The imaging cavity of this system is filled with a newly compounded emulsion that provides a long-term stable and a controllable range of background-to-target dielectric contrasts. The system utilizes a tapered patch antenna array that enables multi-frequency operation. The the enhanced variational Born iterative method with bounding constraints (BC-VBIM) is applied as the inverse solver. Multiple experiments with various phantoms are conducted to evaluate the system's performance and imaging capabilities. Phantom models being used in this work for system evaluation include single, double, and multiple spherical targets filled with various water-isopropyl alcohol mixtures and submerged either directly in the background emulsion or within another water-alcohol mixture that is submerged in the emulsion. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545281 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/89 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 17/00 (20130101) Antennas, i.e Radio Aerials H01Q 9/0485 (20130101) H01Q 21/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201563 | Ledezma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Luis M. Ledezma (La Crescenta, California); Alireza Marandi (Pasadena, California); Robert M. Gray (Pasadena, California); Benjamin K. Gutierrez (Redondo Beach, California) |
| ABSTRACT | On-chip generation of coherent radiation, i.e. laser-like radiation, can be tuned over broad and/or hard-to-access wavelength regions in an integrated platform. Target spectral coverage is beyond what could be achieved with existing integrated laser systems. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/543950 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/39 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/50 (20130101) H01S 5/125 (20130101) H01S 5/141 (20130101) H01S 5/0265 (20130101) H01S 5/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240203629 | Ryland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BUILD BEYOND, LLC (Davis, California) |
| ASSIGNEE(S) | BUILD BEYOND, LLC (Davis, California) |
| INVENTOR(S) | Graham Ryland (West Sacramento, California); John Shepard (Davis, California) |
| ABSTRACT | A system and method for manipulating or heating conductive material. The system comprises: a first electromagnet; a second electromagnet; the first electromagnet and the second electromagnet each comprising: a body; a first pole, the first pole proximal to a working surface; a second pole, the second pole distal to a working surface; a coil at least partially disposed around the body; a modulating controller configured to selectively apply a current to the first or the second electromagnet; the current configured to produce a time-varying flux density at the first pole; and a working volume in communication with the first pole. Manipulation of the material may be contactless and may include, but is not limited to, rotating, levitating, moving, and/or shaping the conductive material. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413614 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/206 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240197250 | Majerus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steve JA Majerus (University Heights, Ohio); Jeremy Dunning (Cleveland Heights, Ohio); Katherine M. Bogie (Cleveland, Ohio); Joseph A. Potkay (Plymouth, Michigan) |
| ABSTRACT | A sensor apparatus includes at least one substrate layer of an elastically deformable material, the substrate layer extending longitudinally between spaced apart ends thereof. A conductive layer is attached to and extends longitudinally between the spaced apart ends of the at least one substrate layer. The conductive layer includes an electrically conductive material adapted to form a strain gauge having an electrical resistance that varies based on deformation of the conductive layer in at least one direction. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413120 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/026 (20130101) A61B 5/683 (20130101) Original (OR) Class A61B 5/02141 (20130101) A61B 5/02444 (20130101) A61B 5/6876 (20130101) A61B 2562/12 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 9/06 (20130101) G01L 9/0052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197830 | Yates-Binder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Tuskegee University (Tuskegee, Alabama); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The United Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Tuskegee University (Tuskegee, Alabama); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Cecelia C. Yates-Binder (Pittsburgh, Pennsylvania); Jesse Jaynes (Tuskegee, Alabama); Monte S. Willis (Indianapolis, Indiana); Richard J. Bodnar (Pittsburgh, Pennsylvania); Zariel I. Johnson (Pittsburgh, Pennsylvania) |
| ABSTRACT | Interferon-γ-inducible protein 10 (IP-10) peptides, IP-10 peptide variants and in silico designed C-X-C chemokine receptor 3 (CXCR3) peptide agonists are described. The small peptides can be used for inhibiting pathological tissue remodeling and treating fibrosis in a subject, such as a subject with fibrosis of the heart, lung, liver, kidney or skin. The peptide agonists can also be used to treat cardiovascular disease, including myocardial infarction and ischemia-reperfusion injury. Also described are in silico designed peptide antagonists that bind CXCR3 or ligands of CXCR3. These antagonist peptides block CXCR3 signaling by disrupting interaction of CXCR3 with its ligand. Antagonist peptides can be used, for example, to treat myocarditis and atherosclerosis. In additional embodiments agonists and antagonists of CXCR4 are disclosed. |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/419845 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/195 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 35/00 (20180101) Peptides C07K 7/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197832 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh – Of The Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoming Hu (Sewickley, Pennsylvania); Jun Chen (Wexford, Pennsylvania); Lawrence R. Wechsler (Pittsburgh, Pennsylvania); Yejie Shi (Pittsburgh, Pennsylvania) |
| ABSTRACT | This document relates to methods and materials involved in treating stroke. For example, nanoparticles (e.g., polymer-coated nanoparticles) designed to deliver two or more poly peptides that are normally secreted from mesenchymal stem cells (MSCs; e.g., MSCs of a human less than 33 years of age)) to the brain are provided as well as methods for using such nanoparticles to treat a mammal (e.g., a human) having or having had a stroke. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 18/288452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 38/30 (20130101) A61K 38/1709 (20130101) A61K 38/1841 (20130101) A61K 38/2026 (20130101) A61K 38/2066 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240201204 | Pieper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Hospitals Cleveland Medical Center (Cleveland, Ohio) |
| ASSIGNEE(S) | University Hospitals Cleveland Medical Center (Cleveland, Ohio) |
| INVENTOR(S) | Andrew A. Pieper (Cleveland, Ohio); Min-Kyoo Shin (Cleveland, Ohio); Edwin Vazquez-Rosa (Cleveland, Ohio) |
| ABSTRACT | In one aspect, disclosed herein is a method of diagnosing and/or prognosing a neurodegenerative disease in a subject, the method comprising: obtaining a plasma or blood sample from a subject; and detecting a level of acetylated Tau in the plasma or blood sample, wherein a level of acetylated Tau that is at least 25% or 50% higher than a control level in a healthy subject indicates that the subject has a neurodegenerative disease such as traumatic brain injury. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/790480 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/335 (20130101) A61K 31/403 (20130101) A61K 31/603 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/4709 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240197850 | BISWAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Debabrata BISWAS (Rockville, Maryland); Jungsoo JOO (Clarksburg, Maryland); Mengfei PENG (Montgomery Village, Maryland) |
| ABSTRACT | Provided are modified bacteria and methods of using the modified bacteria for prophylaxis or treatment of bacterial infections. The modified bacteria contain one or more genomic modifications such that the genomes of the bacteria are altered to encode and produce a holin protein and to encode and produce a lysozyme. The modified bacteria are illustrated using a type of Salmonella enterica (SE) in the form of autolytic SE serovar Typhimurium (S. typhimurium). |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 18/553686 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 39/0275 (20130101) Original (OR) Class A61K 2039/522 (20130101) A61K 2039/542 (20130101) A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/42 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240197855 | Dominowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zoetis Services LLC (Parsippany, New Jersey); United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Joseph Dominowski (Kalamazoo, Michigan); John Morgan Hardham (Kalamazoo, Michigan); James Alan Jackson (Kalamazoo, Michigan); Cyril Gerard Gay (Bethesda, Maryland); Luis Leandro Rodriguez (Niantic, Connecticut); Peter William Krug (East Setauket, New York); Aida Elizabeth Rieder (Westbrook, Connecticut) |
| ABSTRACT | Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 μg FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511123 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/135 (20130101) Original (OR) Class A61K 2039/552 (20130101) A61K 2039/555 (20130101) A61K 2039/5252 (20130101) A61K 2039/55505 (20130101) A61K 2039/55511 (20130101) A61K 2039/55561 (20130101) A61K 2039/55566 (20130101) A61K 2039/55583 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/32034 (20130101) C12N 2770/32134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240199786 | Cochran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric W. Cochran (Ames, Iowa); Xianglan Bai (Ames, Iowa); Wangda Qu (Ames, Iowa); Yuerui Huang (Ames, Iowa); Yixin LUO (Ames, Iowa) |
| ABSTRACT | One aspect of the present application relates to a method of synthesizing a thermoplastic polymer. This method includes providing a depolymerized lignin product comprising monomers and oligomers and producing lignin (meth)acrylate monomers and oligomers from the depolymerized lignin product. A thermoplastic lignin (meth)acrylate polymer is then formed by free radical polymerization of the lignin (meth)acrylate monomers and oligomers. The present application also relates to a branched chain thermoplastic lignin (meth)acrylate polymer which includes a chain transfer agent. The thermoplastic lignin based polymers of the present application can be used to prepare carbon fibers, and engineering thermoplastics. Mixtures of lignin (meth)acrylate monomers and oligomers are also disclosed. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413501 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 293/005 (20130101) Original (OR) Class C08F 2438/01 (20130101) C08F 2438/03 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/12 (20130101) C08J 2397/02 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/12 (20130101) D01F 11/122 (20130101) D01F 11/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240202568 | BURENKOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ivan Alexandrovish BURENKOV (Boyds, Maryland); Sergey Vladimirovich POLYAKOV (Gaithersburg, Maryland) |
| ABSTRACT | A system for quantum-enabled error correction includes a receiver configured to receive an optical signal and detect photons. The optical signal includes encoded information that includes communication alphabet symbols. The receiver includes a processor and a memory that instructions stored thereon, which, when executed by the processor, cause the system to: detect photons by the receiver; determine a set of a posteriori Bayesian probability values based on a period of time of a previous state of the LO and based upon the detected photons; update the LO from the previous state to the next state based on the highest a posteriori Bayesian probability; and determine a likelihood of each of the communication alphabet symbols being correct based on the set of probability values. The next state of the LO is a new input state having a highest probability value that the next state matches the state of the optical signal. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541159 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/01 (20230101) G06N 10/70 (20220101) Original (OR) Class Transmission H04B 10/70 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204783 | Tzimpragos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Georgios Tzimpragos (San Jose, California); Dilip Vasudevan (Emeryville, California); Nestan Tsiskaridze (Santa Barbara, California); Georgios Michelogiannakis (Berkeley, California); Advait Madhavan (Gaithersburg, Maryland); Jennifer Volk (Santa Barbara, California); John Shalf (Oakland, California); Timothy Sherwood (Goleta, California) |
| ABSTRACT | A primitive race-logic temporal operator is described, comprising superconducting logic single flux quantum (SFQ) cells. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/909932 |
| CURRENT CPC | Pulse Technique H03K 3/037 (20130101) H03K 19/20 (20130101) H03K 19/195 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240202915 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, January 17, 2024 |
| APPL NO | 18/415125 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240205000 | Modi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Movius Interactive Corporation (Alpharetta, Georgia) |
| ASSIGNEE(S) | Movius Interactive Corporation (Alpharetta, Georgia) |
| INVENTOR(S) | Amit Modi (Duluth, Georgia); Phil Lowman (Duluth, Georgia) |
| ABSTRACT | Decentralized blockchain enabled mobile communications on a secure, open and distributed network and that is network agnostic. Networks of future will be based on cellular, Wi-Fi, and/or satellite technology, may be private or public, will be decentralized and will provide a variable network capacity, latency and bandwidth. The endpoints for networks will vary but increasingly include several Internet-Of-Things (IOT) endpoints. Peer-to-peer connections traverse many of these networks. As of today, communications networks will continue to exist in secure and not secure embodiments. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/391390 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0866 (20130101) Original (OR) Class H04L 9/0894 (20130101) H04L 9/3073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20240201137 | Alabi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Jesutomi Alabi (Gainesville, Florida); Christopher Charles Ferraro (Gainesville, Florida); Joel B. Harley (Gainesville, Florida); Kyle A. Riding (Gainesville, Florida) |
| ABSTRACT | Various examples related to magnetic non-destructive analysis and testing of ultra-high performance concrete (UHPC). In one example, a method includes positioning a magnetic sensor on or adjacent to a surface of an ultra-high performance concrete (UHPC) structure; determining, using the magnetic sensor, inductance change of the UHPC structure in two directions that are substantially orthogonal to each other; and determining a fiber orientation within the UHPC structure based upon the determined inductance change in the two directions. In another example, a system includes a support structure that supports at least one magnetic sensor on or adjacent to a surface of a UHPC structure; at least one data analyzer that can determine inductance change of the UHPC structure using the at least one magnetic; and processing circuitry configured to determine a fiber orientation within the UHPC structure based upon the determined inductance change. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/566914 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/72 (20130101) Original (OR) Class G01N 33/383 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20240202116 | Kotra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | Jagadish B. Kotra (Austin, Texas); John Kalamatianos (Arlington, Massachusetts); Paul James Moyer (Fort Collins, Colorado); Nicholas Dean Lance (Windsor, Colorado); Sriram Srinivasan (Cedar Park, Texas); Patrick James Shyvers (Fort Collins, Colorado); William Louie Walker (Fort Collins, Colorado) |
| ABSTRACT | An entry of a last level cache shadow tag array to track pending last level cache misses to private data in a previous level cache (e.g., an L2 cache), that also are misses to an exclusive last level cache (e.g., an L3 cache) and to the last level cache shadow tag array. Accordingly, last level cache miss status holding registers need not be expended to track cache misses to private data that are already being tracked by a previous level cache miss status holding register. Additionally or alternatively, up to a threshold number of last level cache pending misses to the same shared data from different processor cores are tracked in the last level cache shadow tag array, and any additional last level cache pending misses are tracked in a last level cache miss status holding register. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068930 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0802 (20130101) Original (OR) Class G06F 2212/1016 (20130101) G06F 2212/1028 (20130101) G06F 2212/1044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20240197789 | SHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Yanhong SHI (Arcadia, California); Jianfei CHAO (Temple City, California); Wendong LI (Duarte, California) |
| ABSTRACT | Disclosed herein are methods of treating Canavan disease in a subject through restoring ASPA enzymatic activities in the subject by expressing exogenous wild type ASPA gene in the brain of the subject. Also disclosed are a process of producing neural precursor cells, including NPCs, glial progenitor cells and oligodendroglial progenitor cells, which express an exogenous wild type ASPA gene and the neural precursor cells produced by this process. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/488859 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2217/075 (20130101) A01K 2227/105 (20130101) A01K 2267/0318 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Original (OR) Class A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0623 (20130101) C12N 5/0696 (20130101) C12N 2501/602 (20130101) C12N 2501/603 (20130101) C12N 2501/604 (20130101) C12N 2501/606 (20130101) C12N 2501/608 (20130101) C12N 2506/45 (20130101) C12N 2506/1307 (20130101) C12N 2510/00 (20130101) C12N 2740/16043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20240201137 | Alabi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Jesutomi Alabi (Gainesville, Florida); Christopher Charles Ferraro (Gainesville, Florida); Joel B. Harley (Gainesville, Florida); Kyle A. Riding (Gainesville, Florida) |
| ABSTRACT | Various examples related to magnetic non-destructive analysis and testing of ultra-high performance concrete (UHPC). In one example, a method includes positioning a magnetic sensor on or adjacent to a surface of an ultra-high performance concrete (UHPC) structure; determining, using the magnetic sensor, inductance change of the UHPC structure in two directions that are substantially orthogonal to each other; and determining a fiber orientation within the UHPC structure based upon the determined inductance change in the two directions. In another example, a system includes a support structure that supports at least one magnetic sensor on or adjacent to a surface of a UHPC structure; at least one data analyzer that can determine inductance change of the UHPC structure using the at least one magnetic; and processing circuitry configured to determine a fiber orientation within the UHPC structure based upon the determined inductance change. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/566914 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/72 (20130101) Original (OR) Class G01N 33/383 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240197177 | Feeney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aptima, Inc. (Woburn, Massachusetts) |
| ASSIGNEE(S) | Aptima, Inc. (Woburn, Massachusetts) |
| INVENTOR(S) | John Feeney (Beavercreek, Ohio); Kevin Durkee (Carmel, Indiana); Zachary Kiehl (Tipp City, Ohio); William Depriest (Centerville, Ohio); Matthew Ewer (Dayton, Ohio); Jeremy Ward (Springboro, Ohio); Korey Arvin (Springfield, Ohio) |
| ABSTRACT | A contextualized sensor system (CSS) is provided comprising one or more sensors, one or more memory elements, an alerting library stored in the one or more memory elements, one or more processors, and the one or more memory elements including instructions that, when executed, cause the one or more processors to perform operations comprising: receiving from one of the one or more sensors one or more sensor data, comparing the first sensor data to the alerting library to determine whether an alert situation has occurred, and communicating an alert if the alert situation has occurred. In some embodiments, the CSS further comprises removable sensor modules and component blocks to provide multiple configurations of CSS components. In some embodiments, the component blocks comprise sensors or power sources. |
| FILED | Thursday, January 18, 2024 |
| APPL NO | 18/416761 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0002 (20130101) Original (OR) Class A61B 5/681 (20130101) A61B 5/746 (20130101) A61B 5/7264 (20130101) A61B 2560/0242 (20130101) A61B 2560/0443 (20130101) A61B 2560/0456 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202278 | Lomen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Brandt J Lomen (Bedford, New Hampshire); Michael C Caron (Merrimack, New Hampshire) |
| ABSTRACT | Systems and methods for sorting signals. One example of a method includes receiving a plurality of data vectors representing a plurality of signals, establishing a sparse primary grid including at least one primary cell in which at least one data vector has been received, based on a first number of data vectors received within the primary cell exceeding a first threshold value, establishing a sparse secondary grid within the primary cell, the sparse secondary grid including at least one secondary cell in which one or more data vectors have been received, based on a second number of data vectors received within the at least one secondary cell exceeding a second threshold value, establishing a first smart object corresponding to the at least one secondary cell, and associating the one or more data vectors received within the at least one secondary cell with the first smart object. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066390 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240202534 | Hershey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul C. Hershey (Ashburn, Virginia); Mu-Cheng Wang (Acton, Massachusetts); Jennifer N. Coston (Ashburn, Virginia); Jennifer L. Ryan (Ashburn, Virginia); Brian D. Scarpiniti (Lower Burrell, Pennsylvania); Darin G. Kabalkin (Ashburn, Virginia); Christopher R. Horner (Fairfax, Virginia) |
| ABSTRACT | A method includes obtaining, using at least one processing device, chat messages being sent to at least one user. The method also includes applying, using the at least one processing device, at least one machine learning model to (i) correct one or more corruptions or deviations contained in at least one of the chat messages and (ii) prioritize the chat messages. The method further includes initiating, using the at least one processing device, display of the prioritized chat messages to the at least one user in a graphical user interface. The at least one machine learning model may include (i) a first machine learning model trained to correct the one or more corruptions or deviations and (ii) a second machine learning model trained to prioritize the chat messages. The first machine learning model may be trained using supervised learning. The second machine learning model may be trained using reinforcement learning. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/066101 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/09 (20230101) Original (OR) Class G06N 3/092 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240204435 | ENGBRECHT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EDWARD R. ENGBRECHT (ODENTON, Maryland); JEFFREY DAVID HARTMAN (SEVERN, Maryland); JUSTIN C. HACKLEY (CATONSVILLE, Maryland) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | EDWARD R. ENGBRECHT (ODENTON, Maryland); JEFFREY DAVID HARTMAN (SEVERN, Maryland); JUSTIN C. HACKLEY (CATONSVILLE, Maryland) |
| ABSTRACT | An electrical connection device is provided that includes a first electrical connector having first electrical contacts formed therein and a second electrical connector having second electrical contacts formed therein. A flexible silicon connector section connects the first electrical connector and the second electrical connector. The connector section includes flexible strands separated by slots, where the flexible strands are flexible in directions orthogonal to a longitudinal direction of the connector section. The flexible strands include metal traces deposited therein to provide an electrical connection between the first electrical connector and the second electrical connector. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068550 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 12/77 (20130101) Original (OR) Class H01R 43/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, June 20, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240620.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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