FedInvent™ Patent Applications
Application Details for Thursday, June 27, 2024
This page was updated on Thursday, July 18, 2024 at 06:17 PM GMT
Department of Health and Human Services (HHS)
| US 20240206439 | SODERLING et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Scott SODERLING (Durham, North Carolina); Akiyoshi UEZU (Durham, North Carolina) |
| ABSTRACT | Provided herein are methods for generating modifiable, stable cell lines. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 18/288505 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) Original (OR) Class A01K 2217/07 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0696 (20130101) C12N 9/22 (20130101) C12N 15/85 (20130101) C12N 15/907 (20130101) C12N 2800/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240206848 | XU et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sheng XU (La Jolla, California); Hongjie HU (La Jolla, California); Hao HUANG (La Jolla, California); Mohan LI (La Jolla, California) |
| ABSTRACT | A stretchable and flexible imaging device that conforms to a shape of patient tissue to which it is attached includes a stretchable and flexible encapsulation substrate and superstrate that is removably attachable to patient tissue. An ultrasound transducer array is disposed between the substrate and superstrate for transmitting and receiving ultrasound waves. The transducer elements are arranged so that data from the received ultrasound waves is processable into an ultrasound image of specified patient tissue. A stretchable and flexible electrical interconnect layered structure is disposed between the superstrate or substrate and the transducer array and is operatively coupled to the transducer elements such that the electrical interconnect layered structure is configured to address the transducer elements. A controller is configured to implement a beamforming algorithm. The controller is in operative communication with the electrical interconnect layered structure for generating the ultrasound images of the specified patient tissue. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 18/288364 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/483 (20130101) A61B 8/0883 (20130101) A61B 8/4236 (20130101) A61B 8/4281 (20130101) Original (OR) Class A61B 8/4427 (20130101) A61B 8/4494 (20130101) A61B 8/5207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207172 | Saltzman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | W. Mark Saltzman (New Haven, Connecticut); Adele S. Ricciardi (New Haven, Connecticut); David H. Stitelman (Branford, Connecticut); James Stephen Farrelly (Milford, Connecticut); Anthony Bianchi (Liverpool, New York) |
| ABSTRACT | Compositions and methods for fetal or in utero delivery of active agents are provided. The compositions are most typically administered intravenously via the vitelline vein, umbilical vein, or directly into the amniotic cavity of a pregnant mother. Fibroblast growth factor is to correct structural defects of neural tissue. |
| FILED | Wednesday, December 27, 2023 |
| APPL NO | 18/397091 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0034 (20130101) Original (OR) Class A61K 9/1647 (20130101) A61K 9/1652 (20130101) A61K 9/5153 (20130101) A61K 38/1825 (20130101) A61K 47/60 (20170801) A61K 48/0041 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207202 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gao Zhang (Philadelphia, Pennsylvania); Qin Liu (Narberth, Pennsylvania); Dario Carlo Altieri (Philadelphia, Pennsylvania); Meenhard Herlyn (Wynnewood, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions for the treatment of cancer are provided. In one embodiment the composition comprises Gamitrinib and a MAPK inhibitor selected from the MAPK inhibitor is selected from RAF265, AZD6244, PLX4720, PD0325901, LGX818, MEK162, vemurafenib, trametinib and dabrafenib. Methods of treating cancer are also provided. |
| FILED | Friday, December 08, 2023 |
| APPL NO | 18/534114 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/06 (20130101) Original (OR) Class A61K 31/155 (20130101) A61K 31/245 (20130101) A61K 31/437 (20130101) A61K 31/713 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5743 (20130101) G01N 2800/44 (20130101) G01N 2800/60 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207207 | GLEMBOTSKI et al. |
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| FUNDED BY |
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| APPLICANT(S) | San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation (San Diego, California); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher C. GLEMBOTSKI (San Diego, California); Erik Alexander BLACKWOOD (San Diego, California); Jeff KELLY (San Diego, California); Rockland WISEMAN (San Diego, California) |
| ABSTRACT | Provided are pharmaceutical compositions, formulations, products of manufacture and kits, and methods, for: mitigating, ameliorating, treating or preventing a proteostasis-based injury; selectively inducing only the ATF6 arm of the unfolded protein response in a cell, a tissue or in a mammal, wherein optionally the mammal is a human; protecting a mammalian heart or a mammalian tissue from an acute or a long term ischemia/reperfusion injury or damage; pharmacologically activating ATF6 or the ATF6 arm of the unfolded protein response in a cell or in vivo; comprising: administering to the cell, the tissue, the mammal or the individual in need thereof: (a) a compound as provided herein, for example, the exemplary compound 147. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/388023 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207212 | Mrsny et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts); UNIVERSITY OF BATH (Bath, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randall Mrsny (Los Altos Hills, California); Beth McCormick (Haverhill, Massachusetts); Roland Ellwood Dolle (Ashland, Massachusetts) |
| ABSTRACT | Disclosed herein are methods and compositions for treating neutrophil-mediated inflammation by targeting, in any combination, the pro-inflammatory MRP2/HXA3 pathway and/or the anti-inflammatory P-gp/endocannabinoid pathway and/or the anti-inflammatory MRP 1/L-AMEND pathway, comprising administering to the subject a therapeutically effective amount of (a) one or more first compound that inhibits the activity and/or level of one or more of multidrug resistance protein 2 (MRP2) and hepoxilin A3 (HXA3) synthase, and/or (b) one or more second compound that increases the level and/or activity of one or more N-acylethanolamines (NAEs), and/or (c) one or more third compound that increases the level and/or activity of multidrug resistance protein 1 (MRP1), wherein the therapeutic amount of the first, second, and third compounds reduces migration of neutrophils into the target tissue. |
| FILED | Wednesday, November 22, 2023 |
| APPL NO | 18/517596 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/195 (20130101) Original (OR) Class A61K 47/60 (20170801) A61K 47/61 (20170801) A61K 47/593 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207219 | Shell et al. |
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| FUNDED BY |
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| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts); The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scarlet S. Shell (Shrewsbury, Massachusetts); Pamela Weathers (Stow, Massachusetts); Joshua J. Kellogg (University Park, Pennsylvania) |
| ABSTRACT | Artemisia annua and A. afra dichloromethane extracts contain bactericidal activity against Mycobacterium tuberculosis (Mtb) strain mc26230 under natural infection stress conditions: carbon source metabolism (glycerol, dextrose, and cholesterol) and hypoxia. Significant bactericidal activity against Mtb was observed regardless of carbon source. Extracts from A. afra showed the highest bactericidal activity against Mtb for tested carbon sources, and A. annua bactericidal activity was greatest against Mtb in minimal media with glycerol. A. annua and A. afra. extracts were bactericidal against Mtb under hypoxic conditions. Growth was halted and viability diminished several logs-fold under hypoxic conditions in the presence of each extract. Transcriptomic analysis revealed that A. afra exerts different effects on Mtb than artemisinin, indicative of phytochemicals in A. afra with unique modes of action. Biochemometric analysis of A. afra resulted in isolation of a methoxylated flavone (compound 1), with considerable activity against Mtb strain mc26230. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392419 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class A61K 36/282 (20130101) A61K 45/06 (20130101) A61K 49/0008 (20130101) A61K 2236/15 (20130101) A61K 2236/39 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207248 | PESTELL et al. |
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| FUNDED BY |
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| APPLICANT(S) | BARUCH S. BLUMBERG INSTITUTE (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard G. PESTELL (Fort Lauderdale, Florida); Yanming DU (Cheshire, Connecticut) |
| ABSTRACT | Described herein are methods for administering a chemotherapeutic agent to a patient in need thereof. Such methods may treat, prevent, or ameliorate tumor CIN associated with administration of a chemotherapeutic agent, resulting in therapeutic resistance, tumor progression and death also described are kits and compositions useful to implement the methods. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 18/287988 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/4741 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207249 | SEDIVY et al. |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M. SEDIVY (Barrington, Rhode Island); Gerwald JOGL (Pawtucket, Rhode Island); Alexandra D'ORDINE (Lakeville, Massachusetts) |
| ABSTRACT | Disclosed are methods for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one long interspersed nuclear element 1 (LINE-1, L1) endonuclease inhibitor (L1 EN inhibitor), either alone or in combination with at least one additional therapeutic agent. Effectiveness of the methods can be measured via biomarkers and/or by a decrease in symptoms compared to those symptoms before administration of the L1 EN inhibitor. Specific chemical structures of the L1 EN inhibitors are identified and shown herein. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537765 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/19 (20130101) A61K 31/50 (20130101) A61K 31/53 (20130101) A61K 31/136 (20130101) A61K 31/145 (20130101) A61K 31/166 (20130101) A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 31/194 (20130101) A61K 31/195 (20130101) A61K 31/196 (20130101) A61K 31/366 (20130101) A61K 31/381 (20130101) A61K 31/423 (20130101) A61K 31/433 (20130101) A61K 31/437 (20130101) A61K 31/445 (20130101) A61K 31/501 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/554 (20130101) A61K 31/4015 (20130101) A61K 31/4035 (20130101) A61K 31/4192 (20130101) A61K 31/4704 (20130101) A61K 31/4741 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207253 | Sklar et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico); THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larry A. Sklar (Albuquerque, New Mexico); Stella Jubay (Albuquerque, New Mexico); Clemencia Panilla (Cardiff, California); Marcello Giulianotti (Vero Beach, Florida); Richard Allen Houghten (Port St. Lucie, Florida); Samuel Lee (Washington, District of Columbia) |
| ABSTRACT | The present invention is directed to compounds which have been identified, as inhibitors of the expression of CDR1 (Cdr1p) and/or CDR2 (Cdr2p), both ABC-type plasma, membrane transporters, which are major contributor to antifungal therapy resistance. These compounds may be used in the treatment of fungal infections, especially Candida infections, either alone or in combination with azole antifungal agents such as fluconazole, itraconazole, miconazole, clotrimazole and the like. Often the inhibitor compounds described herein are useful for reversing the antifungal therapy resistance exhibited by the overexpression of CDR1 and/or CDR2 in strains of fungi, especially including Candida spp. Combination therapy and compositions for treating fungal infections, especially including azole resistant fungal infections represent important embodiments of the present invention. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 18/283035 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/13 (20130101) A61K 31/44 (20130101) A61K 31/137 (20130101) A61K 31/155 (20130101) A61K 31/381 (20130101) A61K 31/495 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/4015 (20130101) A61K 31/4196 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207322 | WOODS et al. |
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| APPLICANT(S) | OSSIUM HEALTH, INC. (San Francisco, California) |
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| INVENTOR(S) | Erik J. WOODS (Carmel, Indiana); Brian H. JOHNSTONE (Fishers, Indiana); Dongsheng GU (Indianapolis, Indiana); Aubrey Marie SHERRY (Carmel, Indiana); Kelsey Gwen MUSALL (Avon, Indiana); Megan SYKES (New York, New York); Tomoaki KATO (New York, New York); Jianing FU (New York, New York) |
| ABSTRACT | Described herein are methods of cell therapies. Also described herein are methods of generating donor derived T cells in an organ transplant recipient, by administering bone marrow stem cells to the organ transplant recipient about 1 to about 30 days after the organ transplant recipient receives one or more organ transplants. |
| FILED | Friday, August 25, 2023 |
| APPL NO | 18/456422 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 35/17 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 35/38 (20130101) A61K 38/1774 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0647 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207329 | Cohen et al. |
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| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York); ROCKEFELLER UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louis J. Cohen (New York, New York); Sean Brady (New York, New York); Scott L. Freidman (New York, New York) |
| ABSTRACT | The presently claimed and described technology provides methods of treating adenocarcinoma in a subject by administering a genetically engineered cell expressing a human microbial N-acyl synthase (hm-NAS) gene, an hm-NAS gene, an N-acyl amide, or compositions thereof. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 18/556218 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/164 (20130101) A61K 35/74 (20130101) Original (OR) Class A61K 38/45 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Enzymes C12Y 203/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207358 | XIAO et al. |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LIPING XIAO (Farmington, Connecticut); Marja HURLEY (Farmington, Connecticut); Tannin SCHMIDT (Farmington, Connecticut) |
| ABSTRACT | The present disclosure is directed to administration of native or recombinant human PRG4 (rhPRG4) as a means to treat sickle cell disease or other disorders in subjects in need of treatment thereof. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 18/288244 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207359 | WOO et al. |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jung A. WOO (Wesley Chapel, Florida); Stephen Bryant LIGGETT (Treasure Island, Florida); David E. KANG (Wesley Chapel, Florida); Yu CHEN (Tampa, Florida); Eric LEWANDOWSKI (Tampa, Florida) |
| ABSTRACT | As disclosed herein, β-arrestin1 and β-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both β-arrestin1 and β-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when β-arrestin2 is overexpressed, tau levels become elevated. The data indicate that β-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of β-arrestin2. Therefore, disclosed herein are β-arrestin oligomerization inhibitors that can be used to prevent β-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a β-arrestin oligomerization inhibitor disclosed herein. |
| FILED | Wednesday, January 24, 2024 |
| APPL NO | 18/421775 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/437 (20130101) A61K 31/496 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207361 | Dowling et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter C. Dowling (Sea Girt, New Jersey); Wei Lu (Sea Girt, New Jersey) |
| ABSTRACT | Described herein are dosing regimens and methods of treating multiple sclerosis with an effective amount of an erythropoietin (EPO)-derived peptide to provide sustained therapeutic effects after withdrawal of the EPO-derived peptide. The dosing regimens and methods include a treatment cycle followed by a rest phase, wherein the EPO-derived peptide is not administered during the rest phase. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 18/555169 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1816 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207378 | Russell et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. Russell (Seattle, Washington); Roli K. Hirata (Seattle, Washington) |
| ABSTRACT | The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in deficiency in MHC class I expression and function. Also provided are the method of using the cells for transplantation and treating a disease condition. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485536 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/28 (20130101) A61K 39/0005 (20130101) Original (OR) Class A61K 2039/515 (20130101) Peptides C07K 14/70539 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/17043 (20130101) C12N 2750/14143 (20130101) C12N 2800/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207383 | Knoot et al. |
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| FUNDED BY |
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| APPLICANT(S) | VaxNewMo LLC (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cory Knoot (St. Louis, Missouri); Christian Harding (St. Louis, Missouri) |
| ABSTRACT | Provided herein are short ComP glycosylation fragments (sequons) and glycoconjugates containing ComP glycosylation fragments, and methods of making and using, for example, for use in the production of glycoconjugate vaccines. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 18/556987 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/092 (20130101) Original (OR) Class A61K 47/549 (20170801) A61K 47/646 (20170801) A61K 2039/6037 (20130101) A61K 2039/6075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207385 | KULP et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel W. KULP (Moorestown, New Jersey); David B. WEINER (Merion, Pennsylvania); Ziyang XU (Philadelphia, Pennsylvania); Kar MUTHUMANI (Cherry Hill, New Jersey) |
| ABSTRACT | The disclosure generally relates to compositions comprising self-assembling vaccines and methods of using the same. The disclosure provides compositions comprising an expressible nucleic acid sequence comprising a first nucleic acid sequence encoding a self-assembling polypeptide or a pharmaceutically acceptable salt thereof and a second nucleic acid sequence encoding a viral antigen or a pharmaceutically acceptable salt thereof. The disclosure further provides compositions comprising an expressible nucleic acid sequence comprising a first nucleic acid sequence encoding a self-assembling polypeptide or a pharmaceutically acceptable salt thereof and a second nucleic acid sequence encoding a CD40 ligand polypeptide. Methods of using any of the disclosed compositions are also provided. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802936 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/545 (20130101) A61K 2039/55516 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207389 | Penaloza-MacMaster |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pablo Penaloza-MacMaster (Evanston, Illinois) |
| ABSTRACT | The present disclosure provides an improved vaccine compositions and methods for eliciting an immune response against SARS-COV-2 and providing broader protection against SARS-COV-2 variants. |
| FILED | Thursday, April 27, 2023 |
| APPL NO | 18/308349 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/545 (20130101) A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207391 | Heaton et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Heaton (Durham, North Carolina); Alfred Harding (Durham, North Carolina); Brook Heaton (Durham, North Carolina); Ryan Chaparian (Durham, North Carolina) |
| ABSTRACT | The present invention provides engineered polynucleotides encoding both the receptor binding domain (RBD) of a SARS-CoV-2 spike protein and an influenza hemagglutinin (HA) protein. Also provided are influenza viruses that comprise the engineered polynucleotides and express both the RBD and HA protein on their surface and methods for using these influenza viruses to generate an immune response to both influenza and SARS-CoV-2 in a subject. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 18/557787 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/5252 (20130101) A61K 2039/5254 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Peptides C07K 14/005 (20130101) C07K 2319/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/2402 (20130101) C12N 2760/16122 (20130101) C12N 2760/16134 (20130101) C12N 2760/16151 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207416 | Kwon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Glen Kwon (Madison, Wisconsin); Yu Tong Tam (Madison, Wisconsin) |
| ABSTRACT | The present technology relates generally to oligolactic acid conjugates and stereocomplexes of conjugates of gemcitabine and gemcitabine derivatives, micelle compositions containing such conjugates or stereocomplexes of conjugates, and methods of preparing and using such compositions to treat various cancers. The oligolactic acid conjugates and stereocomplexes of conjugates may include oligolactic acid comprising 2 to 20 lactic acid subunits and may be attached through an amide linkage to the nitrogen of the 4(N) of the gemcitabine or gemcitabine derivative. Compositions comprising water and a micelle comprising a polylactic acid-containing polymer and the oligolactic acid conjugate or stereocomplex of conjugates may be readily prepared. Methods of inhibiting or killing cancer cells and treating gemcitabine sensitive cancers are also provided. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/424697 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7068 (20130101) A61K 47/593 (20170801) Original (OR) Class A61K 47/6907 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207442 | SIEGWART et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Daniel J. SIEGWART (Dallas, Texas); Lukas FARBIAK (Dallas, Texas) |
| ABSTRACT | In some aspects, the present disclosure provides compositions comprising one or more of each of the following nucleic acids: (1) a mRNA; (2) a sgRNA; and (3) a DNA; and a lipid nanoparticle comprising at least one ionizable lipid; wherein the each of the nucleic acids are encapsulated within the lipid nanoparticle, and pharmaceutical compositions thereof. The present disclosure also provides methods employing said compositions and/or pharmaceutical compositions, such as methods of repairing genes, methods of performing homology directed repair on the genome, and methods of treating diseases or disorders. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 18/556614 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 48/005 (20130101) A61K 48/0041 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/88 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207443 | PAULK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHAN ZUCKERBERG BIOHUB, INC. (SAN FRANCISCO, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | CHAN ZUCKERBERG BIOHUB, INC. (SAN FRANCISCO, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | NICOLE K. PAULK (SAN FRANCISCO, California); JOSEPH L DERISI (SAN FRANCISCO, California); DAVID R. RALEIGH (SAN FRANCISCO, California) |
| ABSTRACT | The invention provides compositions and methods for treatment of glioblastoma and other conditions. In particular, the invention provides a recombinant adeno-associated virus (AAV) vector comprising a transgene encoding one or more interferon polypeptides and a CAG promoter which directs the expression of the transgene. The compositions are particularly suitable for intratumoral administration in gene therapy applications. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 18/012164 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 38/212 (20130101) A61K 38/215 (20130101) A61K 38/217 (20130101) A61K 48/005 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207446 | Meyer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Kathryn Meyer (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides systems and methods for m6A-dependent delivery and m6A-dependent delivery targeted of a polypeptide to a cell. In certain embodiments, compositions, systems, and methods are provided that provide for m6A-dependent delivery of effector proteins, for example, effector proteins, such as a tumor suppression proteins and m6a regulation systems, mediated by CRISPRi in embodiments. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/486146 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/003 (20130101) C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 15/62 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207449 | CHEN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shiming CHEN (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of compositions and methods of making regulatable, adeno-associated viral vectors for the therapeutic expression of CRX and methods of use thereof. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 18/286205 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) C12N 2750/14171 (20130101) C12N 2830/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207458 | MORSE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David MORSE (Valrico, Florida); Haitao JI (Tampa, Florida); Thaddeus WADAS (Iowa City, Iowa); Darpan PANDYA (Coralville, Iowa) |
| ABSTRACT | Disclosed are TATE derivatives having a linker between the TATE moiety and a macrocyclic radionuclide chelating moiety. Methods of synthesis and use are also disclosed. The compounds preferably exhibit a ratio of kidney: liver uptake by a subject within 24 hours of 5 or less, 3 or less, 1 or less, 0.5 or less, preferably from 2:1 to 1:2. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 18/556938 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/083 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207486 | MA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Minglin MA (Ithaca, New York); Longhai WANG (Ithaca, New York); Alexander ERNST (Ithaca, New York) |
| ABSTRACT | Disclosure herein are an implantable cell containing device, its subcomponent scaffold, methods of making the same and their methods of use. The implantable cell containing device includes a scaffold and a cell-containing hydrogel encapsulating the scaffold. The scaffold has a tracheal-like internal system of continuous air-filled, hydrophobic micro-channels that traverse the scaffold's dimensions and a hydrophilic external surface. The implantable cell containing device, when implanted in a subject, can be used for delivering a therapeutic agent to a subject in need thereof for the treatment of various conditions and diseases. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 18/555184 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/34 (20130101) A61L 27/52 (20130101) A61L 27/3804 (20130101) Original (OR) Class A61L 27/3834 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207547 | KACZKA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David KACZKA (Iowa City, Iowa); Jacob HERRMANN (Coralville, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David KACZKA (Iowa City, Iowa); Jacob HERRMANN (Coralville, Iowa) |
| ABSTRACT | The present invention relates to systems and methods for multi-frequency oscillatory ventilation (MFOV). The system uses a broadband flow waveform more suitable for the heterogeneous mechanics of the lung. The system provides more efficient gas exchange and enhanced lung recruitment at lower airway pressures. |
| FILED | Thursday, March 07, 2024 |
| APPL NO | 18/598784 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0006 (20140204) A61M 16/0057 (20130101) Original (OR) Class A61M 16/0096 (20130101) A61M 16/203 (20140204) A61M 2016/0027 (20130101) A61M 2016/0036 (20130101) A61M 2016/102 (20130101) A61M 2230/005 (20130101) A61M 2230/40 (20130101) A61M 2230/46 (20130101) A61M 2230/202 (20130101) A61M 2230/205 (20130101) A61M 2230/208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207617 | Brunner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri); The Regents of the University of Michigan (Ann Arbor, Michigan); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri); The Regents of the University of Michigan (Ann Arbor, Michigan); Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Peter Brunner (St. Louis, Missouri); Markus Adamek (St. Louis, Missouri); Jon Willie (St. Louis, Missouri); Eric Leuthardt (St. Louis, Missouri); Enrico Opri (Ann Arbor, Michigan); Svjetlana Miocinovic (Atlanta, Georgia) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision for systems and methods for individualized targeting of deep brain stimulation (DBS). In addition, methods for monitoring the treatment of a subject using a DBS system are described. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/526386 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36067 (20130101) A61N 1/36139 (20130101) Original (OR) Class A61N 1/36157 (20130101) A61N 1/36171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207637 | Green |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hadiyah-Nicole Green (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hadiyah-Nicole Green (Atlanta, Georgia) |
| ABSTRACT | Methods, structures, devices and systems are disclosed for implementing a photothermal therapy using nanostructures. In one aspect, a device to produce a photothermal effect includes a particle having a molecular layer functionalized onto the external surface of the particle and structured to attach to one or more targeting molecules capable of binding to a receptor site of a cell, in which the particle is configured to absorb light energy at a particular wavelength to produce a plasmon resonance effect that causes the particle to emit heat energy. In some implementations, the device is deployed in an organism having a tumor that includes a plurality of the cell and binds to the receptor site of the tumor by the targeting molecules, in which the light energy is emitted at a region of the organism that contains the tumor and the heat energy causes cellular death of the tumor cell. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594053 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 2005/063 (20130101) A61N 2005/0644 (20130101) A61N 2005/0659 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 3/108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207853 | Beebe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Beebe (Monona, Wisconsin); Duane Juang (Madison, Wisconsin); Terry Juang (Madison, Wisconsin) |
| ABSTRACT | A sample extraction cassette and method are provided to test for a target in a sample. The sample is obtained on a swab. The swab is inserted into a chamber in a case and into contact with a contact portion of a membrane. The contact portion of the membrane is axially moved into sequential communication with a wash fluid and a reaction fluid. The reaction fluid reacts with the target to provide a visual display corresponding to the presence of the target. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/422815 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5029 (20130101) Original (OR) Class B01L 2200/16 (20130101) B01L 2200/141 (20130101) B01L 2200/0636 (20130101) B01L 2300/069 (20130101) B01L 2300/161 (20130101) B01L 2300/0829 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208070 | YIM |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (Seoul, South Korea) |
| ASSIGNEE(S) | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (Seoul, South Korea) |
| INVENTOR(S) | Sehyuk YIM (Seoul, South Korea) |
| ABSTRACT | An intelligent robot according to an embodiment is disclosed. The intelligent robot according to an embodiment includes at least one processor and a memory configured to store instructions for executing the at least one processor, wherein the intelligent robot includes a plurality of members stacked with gaps to form a shape of a face, and at least one flexible structure disposed in at least one of the gaps, and wherein when the instructions are executed by the at least one processor, the instructions cause the at least one processor to control a motion of the face by applying a force to a power transmission element connected to at least one of the plurality of members based on an audio input. |
| FILED | Thursday, April 20, 2023 |
| APPL NO | 18/303650 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/161 (20130101) B25J 11/0015 (20130101) Original (OR) Class B25J 13/003 (20130101) B25J 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208898 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Justin Kim (Jamaica Plain, Massachusetts); Dahye Kang (Brookline, Massachusetts); Sheldon T. Cheung (Spring House, Pennsylvania) |
| ABSTRACT | Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/283264 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/04 (20130101) A61K 31/553 (20130101) A61K 31/695 (20130101) A61K 31/5375 (20130101) Acyclic or Carbocyclic Compounds C07C 215/24 (20130101) C07C 291/04 (20130101) Original (OR) Class Heterocyclic Compounds C07D 498/22 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208936 | HODGETTS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin HODGETTS (Boston, Massachusetts); Chien-Liang Glenn LIN (Columbus, Ohio) |
| ABSTRACT | Disclosed are compounds that activate excitatory amino acid transporter 2 (EAAT2), as well as methods of using these compounds to treat or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity. |
| FILED | Tuesday, July 18, 2023 |
| APPL NO | 18/354330 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/22 (20180101) A61P 25/24 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 237/14 (20130101) C07D 401/04 (20130101) C07D 401/14 (20130101) Original (OR) Class C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208944 | Ganesh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thota Ganesh (Cumming, Georgia); Radhika Amaradhi (Decatur, Georgia); Jacek Zielonka (Wauwatosa, Wisconsin) |
| ABSTRACT | The disclosure relates to quinazoline derivatives, pharmaceutical compositions, and therapeutic methods related thereto. In certain embodiments, this disclosure relates to compounds and methods of treating or preventing a Nox-related disease comprising administering to a subject a pharmaceutical composition comprising a Nox inhibitor or derivative reported herein. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 18/287632 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Heterocyclic Compounds C07D 235/28 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208973 | OLSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David E. OLSON (Oakland, California); Jeremy R. TUCK (Oakland, California); Lee E. DUNLAP (Oakland, California) |
| ABSTRACT | Provided herein are tetracyclic heterocyclic compounds which can be useful for methods of treating a disease or for increasing neural plasticity. The compounds can also be useful for increasing dendritic spine density. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 18/554762 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Heterocyclic Compounds C07D 471/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208984 | ZHANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan ZHANG (Glen Allen, Virginia) |
| ABSTRACT | Bivalent ligands which bind to MOR-CCR5 heterodimers are provided. The bivalent ligands comprise two discrete pharmacophores, naltrexone and maraviroc, linked by a spacer and bind to MOR-CCR5 heterodimers, e.g. at the surface of a cell. The bivalent ligands are useful in assays to detect MOR-CCR5 heterodimers, as therapeutic agents to prevent and/or treat diseases characterized by the presence of MOR-CCR5 heterodimers. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 18/552761 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 31/485 (20130101) A61K 47/55 (20170801) Heterocyclic Compounds C07D 489/08 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209031 | Asokan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravind Asokan (Chapel Hill, North Carolina); Giridhar Murlidharan (Quincy, Massachusetts); Blake Albright (Carrboro, North Carolina) |
| ABSTRACT | The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/409304 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209032 | Kwong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United State of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United State of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Peter Kwong (Washington, District of Columbia); Barney Graham (Smyrna, Georgia); John Mascola (Rockville, Maryland); Li Ou (Potomac, Maryland); Aliaksandr Druz (Germantown, Maryland); Man Chen (Clarksburg, Maryland); Wing-Pui Kong (Germantown, Maryland); Ivelin Stefanov Georgiev (Nashville, Tennessee); Emily Rundlet (New York, New York); Michael Gordon Joyce (Washington, District of Columbia); Yaroslav Tsybovsky (Brunswick, Maryland); Paul Thomas (Washington, District of Columbia); Marie Pancera (Seattle, Washington); Mallika Sastry (Rockville, Maryland); Cinque Soto (Nashville, Tennessee); Joseph Van Galen (North Wales, Pennsylvania); Guillaume Stewart-Jones (Cambridge, Massachusetts); Yongping Yang (Potomac, Maryland); Baoshan Zhang (Bethesda, Maryland); Ulrich Baxa (Frederick, Maryland) |
| ABSTRACT | Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/409645 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/12 (20130101) A61K 2039/53 (20130101) A61K 2039/543 (20130101) A61K 2039/5252 (20130101) A61K 2039/5254 (20130101) A61K 2039/55505 (20130101) A61K 2039/55561 (20130101) A61K 2039/55566 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 37/04 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/21 (20130101) C07K 2319/22 (20130101) C07K 2319/50 (20130101) C07K 2319/70 (20130101) C07K 2319/735 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/10343 (20130101) C12N 2760/18522 (20130101) C12N 2760/18523 (20130101) C12N 2760/18534 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209034 | SELLERS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington); Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Drew SELLERS (Seattle, Washington); Ian CARDLE (Seattle, Washington); Suzie Hwang PUN (Seattle, Washington) |
| ABSTRACT | Embodiments of the claimed invention are directed to synthetic peptides comprising an amino acid sequence of X1X2VX3NLRGDLQVLX4QKVCX5T (SEQ ID NO:18), wherein at least one of X1 and X2 is a cysteine, and wherein one or more of X3, X4, and X5 is a non-natural amino acid. Also described are methods of using the claimed embodiments for inhibiting growth of a cancer cell overexpressing integrin αvβ6. Additionally, also described are methods of using the claimed embodiments for detecting a cancer cell overexpressing integrin αvβ6. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/554737 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/32122 (20130101) C12N 2770/32133 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209047 | Raghunathan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vijay Krishna Raghunathan (Houston, Texas); Christopher J. Murphy (Madison, Wisconsin); Nicholas L. Abbott (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vijay Krishna Raghunathan (Houston, Texas); Christopher J. Murphy (Madison, Wisconsin); Nicholas L. Abbott (Madison, Wisconsin) |
| ABSTRACT | The present invention relates to the treatment of chronic wounds, and in particular to treatment of chronic wounds by via the use of growth factors conjugates that are immobilized in the wound. Specifically, the growth factor (GF) conjugates comprising a GF molecule covalently modified with a chemical moiety comprising a reactive functionality. Further disclosed arm GF molecules that are used for the conjugates and the chronic wounds can be treated using the GF conjugates. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/287249 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/54 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Peptides C07K 14/475 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209058 | Stromnes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); FRED HUTCHINSON CANCER CENTER (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ingunn Stromnes (Minneapolis, Minnesota); Philip D. Greenberg (Seattle, Washington); Thomas M. Schmitt (Seattle, Washington) |
| ABSTRACT | Mesothelin-specific binding proteins including mesothelin-specific T cell receptor (TCR) that specifically binds to mesothelin including. for example. in a complex with an MHC. Methods of making and using the mesothelin-specific binding proteins are also described, including the use of the mesothelin-specific binding protein in adoptive cell therapy. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 18/288420 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/4632 (20230501) A61K 39/464468 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209059 | Tran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Eric Tran (Portland, Oregon); Yong-Chen Lu (Little Rock, Arkansas); Anna Pasetto (Asker, Norway); Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland); Zhili Zheng (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/423020 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/82 (20130101) C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) G01N 2333/7051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209070 | IBRAHIM |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashraf S. IBRAHIM (Irvine, California) |
| ABSTRACT | Presented herein, in certain embodiments, are binding agents that specifically bind to CotH3 and uses thereof. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/558138 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/7048 (20130101) A61K 39/39575 (20130101) Peptides C07K 16/14 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209072 | Hotamisligil et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Gokhan S. Hotamisligil (Wellesley, Massachusetts); Haiming Cao (Bethesda, Maryland) |
| ABSTRACT | A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an inhibitor of secreted aP2, secretion of aP2, or a serum aP2 blocking agent. For example, glucose intolerance is reduced following administration of such an inhibitor or agent. Exemplary compositions inhibit cellular secretion of aP2 or bind to circulating aP2, thereby reducing the level or activity of aP2 in blood or serum. |
| FILED | Monday, June 26, 2023 |
| APPL NO | 18/341404 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209302 | Hernandez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Jonathan Matthew Hernandez (Bethesda, Maryland); Thomas J. Pohida (Bethesda, Maryland); Marcial Antonio Garmendia (Bethesda, Maryland); Samantha Marilyn Ruff (Bethesda, Maryland); Michael Martin Wach (Bethesda, Maryland); Shreya Gupta (Bethesda, Maryland); James McDonald (Bethesda, Maryland); Kirsten Remmert (Bethesda, Maryland); Alexander Joseph Rossi (Bethesda, Maryland) |
| ABSTRACT | Ex vivo analysis can be performed by mounting a portion of live tissue resected from a patient on a sample platform. Using the sample platform, the resected tissue portion can be positioned within a perfusion chamber. Perfusate is flowed through the perfusion chamber and into contact with the resected tissue portion such that diffusion of oxygen occurs between the perfusate and the resected tissue portion. During the flowing, the resected tissue portion maintains a competent immune system. Drugs can be added to the perfusate flow to ascertain the effect on the tissue. The sample platform is designed to be removable from the perfusion chamber for analysis of the tissue by imaging or other investigation techniques, for experimental treatment, or for any other purpose. After removal, the sample platform can be returned to the perfusion chamber for continued viability of the tissue. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/910911 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 29/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209313 | Lee-Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Catalina Lee-Chang (Skokie, Illinois); Maciej S. Lesniak (Evanston, Illinois) |
| ABSTRACT | The present invention provides methods of making anti-cancer compositions by activating 4-1BBL+ B cells using a CD40 agonist and IFNγ. The anti-cancer compositions produced by these methods may be used as an immunotherapy for the treatment of cancer. either alone or in combination with radiation, chemotherapeutics and/or checkpoint blockade. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 18/021687 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) Original (OR) Class C12N 2501/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209318 | Chancellor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael B. Chancellor (Pittsburgh, Pennsylvania); Ronald Jankowski (Pittsburgh, Pennsylvania); Ryan Pruchnic (Pittsburgh, Pennsylvania); Johnny Huard (Wexford, Pennsylvania) |
| ABSTRACT | The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for urinary incontinence and other urinary tract pathologies. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/358465 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/34 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0658 (20130101) Original (OR) Class C12N 2500/38 (20130101) C12N 2501/11 (20130101) C12N 2501/39 (20130101) C12N 2501/91 (20130101) C12N 2501/105 (20130101) C12N 2501/115 (20130101) C12N 2501/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209321 | Ng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Hon Man Alex Ng (Cambridge, Massachusetts); George M. Church (Cambridge, Massachusetts); Volker Busskamp (Cambridge, Massachusetts) |
| ABSTRACT | Forced expression of a handful of transcription factors (TFs) can induce conversions between cell identities; however, the extent to which TFs can alter cell identity has not been systematically assessed. Here, we assembled a human TFome, a comprehensive expression library of 1,578 human TF clones with full coverage of the major TF families. By systematically screening the human TFome, we identified 77 individual TFs that induce loss of human-induced-pluripotent-stem-cell (hiPSC) identity, suggesting a pervasive ability for TFs to alter cell identity. Using large-scale computational cell type classification trained on thousands of tissue expression profiles, we identified cell types generated by these TFs with high efficiency and speed, without additional selections or mechanical perturbations. TF expression in adult human tissues only correlated with some of the cell lineage generated, suggesting more complexity than observation studies can explain. |
| FILED | Friday, October 27, 2023 |
| APPL NO | 18/496419 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Original (OR) Class C12N 5/0605 (20130101) C12N 5/0623 (20130101) C12N 5/0626 (20130101) C12N 5/0658 (20130101) C12N 5/0662 (20130101) C12N 5/0686 (20130101) C12N 5/0696 (20130101) C12N 2501/60 (20130101) C12N 2503/02 (20130101) C12N 2506/45 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209325 | Steinmetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Steinmetz (La Jolla, California); Jooneon Park (La Jolla, California); Young Hun Chung (La Jolla, California) |
| ABSTRACT | Methods and compositions for the treatment of cancer provided herein. The compositions and methods contain a nanoparticle and a peptide that targets S100A9. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/554979 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 39/12 (20130101) A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2770/14023 (20130101) C12N 2770/14034 (20130101) C12N 2770/18023 (20130101) C12N 2770/18034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209329 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Brian Chaikind (Cambridge, Massachusetts); Jeffrey L. Bessen (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide a fusion protein comprising a guide nucleotide sequence-programmable DNA binding protein domain (e.g., a nuclease-inactive variant of Cas9 such as dCas9), an optional linker, and a recombinase catalytic domain (e.g., a tyrosine recombinase catalytic domain or a serine recombinase catalytic domain such as a Gin recombinase catalytic domain). This fusion protein can recombine DNA sites containing a minimal recombinase core site flanked by guide RNA-specified sequences. The instant disclosure represents a step toward programmable, scarless genome editing in unmodified cells that is independent of endogenous cellular machinery or cell state. |
| FILED | Friday, May 26, 2023 |
| APPL NO | 18/324394 |
| CURRENT CPC | Peptides C07K 4/00 (20130101) C07K 2319/09 (20130101) C07K 2319/21 (20130101) C07K 2319/43 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1241 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2320/11 (20130101) Enzymes C12Y 207/07 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209334 | Woo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Christina M. Woo (Cambridge, Massachusetts); Yun Ge (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides glycosyl hydrolases (e.g., OGA) comprising a ligand-dependent intein. The present disclosure also provides pharmaceutical compositions comprising the glycosyl hydrolases disclosed herein, as well as polynucleotides, vectors, cells, and kits. Methods of using the disclosed intein-containing glycosyl hydrolases are also provided herein, including methods of deglycosylating a target protein. Methods of treating a glycosylation-associated disease in a subject, as well as methods of sensitizing a cell to a desirable therapeutic outcome, are also provided herein. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/394724 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 2319/09 (20130101) C07K 2319/095 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Enzymes C12Y 302/01169 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/502 (20130101) G01N 2333/924 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209338 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Tina Wang (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure relate to strategies, systems, methods, compositions, and kits that are useful for production (e.g., evolution) of cytidine deaminase protein variants that are characterized by increased soluble expression and/or stability relative to the wild-type cytidine deaminase protein from which they are evolved. In some embodiments, evolved cytidine deaminase variants described by the disclosure are useful for incorporation into targeted nucleic acid editing proteins, for example in fusion proteins with a Cas9 domain or variant thereof. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/419414 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) Original (OR) Class Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209341 | MILLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yury MILLER (San Diego, California); Soo-Ho CHOI (San Diego, California) |
| ABSTRACT | Provided are methods for modification of amino acid sequence and increasing levels of expression of ApoA-I Binding Protein to treat: a neuropathic pain, a CNS inflammation, an allodynia, a post nerve injury pain, a post-surgical pain, a chemotherapeutic-induced peripheral neuropathy, a neurodegeneration, including for example, a neurodegenerative disease or condition such as Alzheimer's disease, a hyperalgesia, primary headaches such as migraines and cluster headaches, glaucoma or other inflammatory diseases of the eye, lung inflammation, asthma, HIV infection, vascular inflammation, atherosclerosis and cardiovascular disease. Provided are methods comprising administering pharmaceutical compositions comprising a recombinantly modified APOA1BP polypeptide to treat a neuropathic pain, an allodynia, a hyperalgesia, a neurodegenerative disease, a primary headache such as a migraine, glaucoma, lung inflammation and asthma, acute respiratory distress syndrome (ARDS), sepsis, viral infection, including influenza, coronavirus (for example, COVID-19) or HIV infection, or its comorbidities, and/or vascular inflammation, atherosclerosis and cardiovascular disease. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 18/282749 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/52 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) A61P 25/00 (20180101) A61P 27/06 (20180101) Peptides C07K 2319/02 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) Original (OR) Class Enzymes C12Y 501/99006 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209345 | Nicchitta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Nicchitta (Durham, North Carolina); Johncarlo Kristoflch (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods related to the isolation of nucleic acids from a sample. In particular, the disclosure provides compositions comprising an alcohol and a monovalent salt and methods of us thereof for isolation of nucleic acids, including RNA-protein complexes (RNPs), from a biological sample. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/510007 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209353 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); Memorial Hospital for Cancer and Allied Diseases (New York, New York); Sloan-Kettering Institute for Cancer Research (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); Memorial Hospital for Cancer and Allied Diseases (New York, New York); Sloan-Kettering Institute for Cancer Research (New York, New York) |
| INVENTOR(S) | Craig B. Thompson (New York, New York); Simon Schwoerer (New York, New York); Jiajun Zhu (New York, New York) |
| ABSTRACT | Aspects of the disclosure provide methods for inhibiting cell proliferation and protein synthesis utilizing an antagonist of nicotinamide adenine dinucleotide kinase 2 (NADK2). In some aspects, these methods are used to treat a disease such as cancer or a disorder such as a fibrotic disorder. Further provided herein are compositions comprising a nutrient-deficient cell culture medium and an antagonist of NADK2. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 18/285925 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209359 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng ZHANG (Cambridge, Massachusetts); Naomi HABIB (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed are locational or positional methods concerning CRISPR-Cas systems, and apparatus therefor. |
| FILED | Monday, July 24, 2023 |
| APPL NO | 18/225531 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/79 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 15/1082 (20130101) C12N 2310/10 (20130101) C12N 2310/20 (20170501) C12N 2320/11 (20130101) C12N 2320/30 (20130101) C12N 2750/14143 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 20/30 (20190201) G16B 20/50 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209360 | Flanigan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Flanigan (Columbus, Ohio); Nicolas Sebastien Wein (Columbus, Ohio); Tabatha Simmons (Columbus, Ohio); Adeline Vulin-Chaffiol (Columbus, Ohio) |
| ABSTRACT | Products and methods for treating or preventing muscular dystrophies in patients with mutations in the 5′ end of their DMD gene are provided. In some aspects, oligonucleotides, antisense phosphorodiamidate morpholino oligomers (PMO), and antisense cell penetrating peptide-conjugated PMOs (PPMOs) are provided for skipping exon 2 of the DMD gene. These oligonucleotides and oligomers can selectively suppress mutant forms of the dystrophin protein while allowing a functional form of the dystrophin protein to be expressed in sufficient quantity to retain its function in the cell. The oligonucleotides or oligomers can regulate or restore expression of transcripts of the DMD gene and a functional form of the dystrophin protein. Methods comprising administering the oligonucleotides. PMO, and PPMO targeting the DMD gene are provided. The products and methods are used for treating, ameliorating and/or preventing muscular dystrophies, such as Duchenne Muscular Dystrophy or Becker Muscular Dystrophy. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 18/287682 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/3233 (20130101) C12N 2310/3513 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209376 | Susorov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Denis Susorov (Worcester, Massachusetts); Andrei Korostelev (Shrewsbury, Massachusetts); Seraj Zahra (Worcester, Massachusetts) |
| ABSTRACT | This invention is related to the field of genetic engineering. In particular, it is related to compositions and methods to treat genetically-based diseases and disorders. For example, nucleic acid oligomers are contemplated that promote translation readthrough of premature stop codons that produce non-functional proteins. DNA and modified nucleic acid oligos that bind at the +4 through +8 (+4, +5, +6, +7 and +8) nucleotide position downstream of a premature stop codon successfully promoted readthrough of a premature stop codon in a cystic fibrosis gene. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 18/553357 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209394 | Musolino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patricia L. Musolino (Boston, Massachusetts); Casey A. Maguire (Arlington, Massachusetts); Eloise Hudry (Roxbury Crossing, Massachusetts); Killian S. Hanlon (Boston, Massachusetts) |
| ABSTRACT | Described herein are capsid peptides that mediated efficient AAV transduction of the brain vasculature, mainly endothelial cells and pericytes, as well as smooth muscle cells, compositions (including AAV), and methods of using the same. Embodiments of the invention encompass AAV capsid proteins comprising an amino acid sequence that comprises at least four, at least five, or at least six contiguous amino acids from the sequence PRPPSTH (SEQ ID NO: 1); MAEPGAR (SEQ ID NO: 2); SQDPSTL (SEQ ID NO: 3); or MLYADNT (SEQ ID NO: 4). |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 18/288460 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209399 | Sternberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Henry Sternberg (New York, New York); George Davis Lampe (New York, New York); Rebeca Teresa King Davidson (New York, New York) |
| ABSTRACT | The present disclosure provides systems, kits, and methods provide systems and methods for recruiting one or more effector domains to a target nucleic acid and or modulating expression of a target gene in a cell utilizing an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated (Cas) system. More particularly, the present disclosure provides systems comprising: an engineered CRISPR-Cas system or one or more nucleic acids encoding the engineered CRISPR-Cas system, wherein the CRISPR-Cas system comprises: at least one Cas protein (e.g., Cas6, Cas7, Cas5, Cas8 and/or Cas12k); a guide RNA (gRNA) complementary to at least a portion of the target nucleic acid sequence; and, optionally, at least one transposon-associated protein (e.g., TniQ, TnsC, TnsA, and/or TnsB). |
| FILED | Friday, June 17, 2022 |
| APPL NO | 18/570914 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) C12N 2800/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209424 | Salaita et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Khalid Salaita (Atlanta, Georgia); Brendan Deal (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to spherical nucleic acids comprising a group of nucleic acids that hybridize separate segments of a target nucleic acid for therapeutic and diagnostic applications. In certain embodiments, this disclosure relates to patterning spherical nucleic acids in tandem for hetero-multivalent hybridization to segments of a target nucleic acid. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/909844 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/146 (20130101) A61K 45/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6834 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209430 | HE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Chuan HE (Chicago, Illinois); Ji NIE (Chicago, Illinois); Xiao-Long CUI (Chicago, Illinois) |
| ABSTRACT | The methods, compositions, and kits of the disclosure provide a novel approach for a whole genome, unbiased DNA analysis method that can be performed on limited amounts of DNA can be used to analyze DNA to determine its modification status. Aspects of the disclosure relate to a method for amplifying bisulfite-treated deoxyribonucleic acid (DNA) molecules comprising: (a) ligating an adaptor to the DNA molecules, wherein the adaptor comprises a RNA polymerase promoter comprising bisulfite-protected cytosines; (b) treating the ligated DNA molecules with bisulfite; (c) hybridizing the bisulfite-treated DNA molecules with a primer; (d) extending the hybridized primer to make double stranded DNA; and (e) in vitro transcribing the double-stranded DNA to make RNA. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410490 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6865 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240209445 — A CONTINUOUS METRIC TO MEASURE ENDOTYPE AND CORTICOSTEROID INTERACTION IN SEPTIC SHOCK
| US 20240209445 | WONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio); VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio); VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Hector WONG (Cincinnati, Ohio); Christopher LINDSELL (Nashville, Tennessee) |
| ABSTRACT | Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood, vascular, cardiac, and respiratory tract dysfunction, particularly as those responses relate to septic shock in patients, such as pediatric. In particular, the invention relates to analyzing biomarkers associated with septic shock in pediatric patients, obtaining a sample from a patient having at least one indication of septic shock, then determining the gene expression mosaic for the patient, wherein the gene expression mosaic can correlate with a predicted outcome and can inform treatment strategy. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/264741 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209447 | Cong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Le Cong (Stanford, California); Nicholas W. Hughes (Stanford, California) |
| ABSTRACT | The present disclosure provides systems, methods, nucleic acids, and kits for barcoding and tracking cells based on CRISPR editing technologies. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/287619 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) C12Q 1/6813 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/922 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/50 (20190201) G16B 25/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209452 | Vrba et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lukas Vrba (Tucson, Arizona); Bernard W. Futscher (Tucson, Arizona) |
| ABSTRACT | Cancer specific DNA methylation regions have been studied to find cancer specific DNA methylation markers for most common cancers. Differentially methylated regions for individual cancer types were identified and those were further filtered against data from normal tissues to obtain marker regions with cancer specific methylation, resulting in total of 1,250 hypermethylated and 584 hypomethylated marker CpGs. Optimal sets of six markers for each TCGA cancer type that could identify most tumors with high specificity and sensitivity (AUC 0.969-1.00) were chosen from hypermethylated markers and a universal 12 marker set that can detect tumors of all 33 TCGA cancer types (AUC>0.84) was also chosen from hypermethylated markers. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/542277 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209456 | TENEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BETH ISRAEL DEACONESS MEDICAL CENTER (Boston, Massachusetts); UNIVERSITY OF PORTSMOUTH (Portsmouth, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Geoffrey TENEN (Boston, Massachusetts); Annalisa DI RUSCIO (Boston, Massachusetts); Alexander K. EBRALIDZE (Boston, Massachusetts); Colyn CRANE-ROBINSON (Portmouth, United Kingdom); Simone UMMARINO (Boston, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods of treating cancer in a subject in need thereof, relating to a specific non-coding RNA (ncRNA)-S Phase Early RNAs (SPEARs) or inhibitors thereof. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 18/557277 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6851 (20130101) C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210384 | SCHNEIDER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia); EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca S. SCHNEIDER (Atlanta, Georgia); Andres J. GARCIA (Atlanta, Georgia); Wilbur A. LAM (Atlanta, Georgia); Evelyn Kendall WILLIAMS (Atlanta, Georgia); Karen E. MARTIN (Atlanta, Georgia) |
| ABSTRACT | A high-throughput, scalable, low-cost, on-chip microfluidic potency assay for nondifferentiated cells such as human mesenchymal stromal cells (hMSCs) with improved functional predictive power and recapitulation of in vivo secretory responses compared to traditional approaches. By comparison of hMSC secretory responses to functional hMSC-medicated immune cell suppression, on-chip microfluidic potency markers are identified with improved functional predictive power compared to traditional planar methods. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 18/558026 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) Original (OR) Class G01N 2333/57 (20130101) G01N 2333/96494 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210393 | Mozaffarian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seattle Children's Hospital (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital (Seattle, Washington) |
| INVENTOR(S) | Neelufar Mozaffarian (Mercer Island, Washington); Anne M. Stevens (Seattle, Washington) |
| ABSTRACT | Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand. |
| FILED | Friday, December 29, 2023 |
| APPL NO | 18/400666 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0082 (20130101) A61B 5/4842 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 38/06 (20130101) A61K 38/07 (20130101) A61K 39/3955 (20130101) Peptides C07K 16/2803 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 2333/70503 (20130101) G01N 2800/56 (20130101) G01N 2800/102 (20130101) G01N 2800/104 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 436/811 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210395 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Melody Smith (New York, New York); Marcel Van den Brink (New York, New York); Eric Pamer (Montclair, New Jersey); Eric Littmann (New York, New York) |
| ABSTRACT | The present invention relates to compositions, methods, and kits for predicting a subject's response to a CAR T cell therapy, by analyzing the intestinal microbiome of the subject. The present disclosure also provides a method of detecting patients at risk for a poor response to CAR T cell therapy by measuring the level of the presently disclosed bacteria or bacterial genes in the microflora or microbiome of a patient receiving or considered for CAR T cell therapy. The present disclosure further provides therapeutic compositions and methods for treating a subject having a cancer, by improving the subject's response to a CAR T cell therapy. |
| FILED | Friday, December 29, 2023 |
| APPL NO | 18/400766 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/74 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) Original (OR) Class G01N 2496/00 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210412 | Hsu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Ku-Lung Hsu (Charlottesville, Virginia); Anthony Michael Ciancone (Bethesda, Maryland); Robert Justin Grams (Waynesboro, Virginia) |
| ABSTRACT | Sulfonyl-triazole compounds and related sulfonyl-heterocycle compounds are described. Exemplary compounds can form covalent adducts with reactive nucleophilic amino acid residues in proteins, such as reactive tyrosines, to form modified proteins and/or to alter the biological activity of the proteins. Pharmaceutical compositions comprising the compounds and methods of inhibiting prostaglandin reductase 2 (PTGR2) are also described. In addition, methods are described for screening proteins to identify druggable amino acid residues, e.g., druggable tyrosine and/or lysine residues. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 18/286978 |
| CURRENT CPC | Heterocyclic Compounds C07D 249/08 (20130101) C07D 401/04 (20130101) C07D 401/12 (20130101) C07D 405/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/6848 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210415 | KRAMMER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| INVENTOR(S) | Florian KRAMMER (New York, New York); Adolfo FIRPO-BETANCOURT (New York, New York); Carlos CORDON-CARDO (New York, New York); Damodara Rao MENDU (Ellicott City, Maryland); Viviana SIMON (New York, New York); Fatima AMANAT (Jamaica, New York); Daniel STADLBAUER (New York, New York) |
| ABSTRACT | Provided herein are recombinant SARS-CoV-2 spike proteins, cells producing such proteins, and kits comprising such proteins. Also provided herein are compositions comprising recombinant SARS-CoV-2 spike proteins and methods of detecting antibodies using such SARS-CoV-2 spike proteins. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/913783 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/34 (20130101) G01N 1/44 (20130101) G01N 21/59 (20130101) G01N 33/6854 (20130101) Original (OR) Class G01N 33/54366 (20130101) G01N 33/56983 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210671 | Lew et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Lew (St. Louis, Missouri); Oumeng Zhang (St. Louis, Missouri) |
| ABSTRACT | An imaging system uses a multi-view reflector (MVR) to simultaneously measure the three-dimensional (3D) position and orientation of a light emitter. The MVR is positioned at a back focal plane (BFP) of a light collecting optical system, and uses pyramid reflectors and/or conical reflectors to reflect light in at least two regions of the BFP to at least two detection channels of a detector. The at least two detection channels produce images that are used to determine the 3D position and orientation of a light emitter. The system may be used, for example, to image the structure of molecules or organelles in a cell, track the movement of molecules in a cell, or to study the interaction of molecules within a cell. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 18/254448 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/18 (20130101) G02B 21/361 (20130101) Original (OR) Class G02B 27/14 (20130101) G02B 27/283 (20130101) G02B 27/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210878 | VARSHNEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amitabh VARSHNEY (Potomac, Maryland); Susmija JABBIREDDY (Berwyn Heights, Maryland); Mario DAGENAIS (Chevy Chase, Maryland); Martin C. PECKERAR (Silver Spring, Maryland); Yang ZHANG (Silver Spring, Maryland) |
| ABSTRACT | Sparse nanophotonic arrays (NPAs) and holographic displays comprise a rectangular footprint including an active pixel area, wherein the active pixel area includes a plurality of light-emitting elements arranged in a starburst shape, and wherein a total number of the plurality of light-emitting elements in the active pixel area is equal to a predetermined fraction of a total resolution of a dense nanophotonic array having the rectangular footprint. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/542174 |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/265 (20130101) Original (OR) Class G03H 2001/2655 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212138 | Potter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BioSensics LLC (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilkay Yildiz Potter (Boston, Massachusetts); Ashkan Vaziri (Newton, Massachusetts) |
| ABSTRACT | Systems and methods for automated and rapid detection of free fluid. An example method includes obtaining medical images associated with a patient, the medical images being ultrasound images depicting different portions of the patient, and the ultrasound images forming video of the different portions; providing the medical images to a machine learning model, wherein a forward pass through the machine learning model is computed, and wherein the machine learning model is trained to output for each input medical image, a bounding box about free fluid depicted in the input medical image and a confidence score associated with detection of the free fluid in the bounding box; and determining that the patient has free fluid based on analyzing output from the machine learning model. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/391383 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2200/24 (20130101) G06T 2207/10016 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30048 (20130101) G06T 2210/12 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212143 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, January 17, 2024 |
| APPL NO | 18/415137 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212994 | Stoltz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter H. Stoltz (Denver, Colorado); Eric T. Meier (Seattle, Washington); Uri Shumlak (Seattle, Washington); Brian A. Nelson (Edmonds, Washington) |
| ABSTRACT | Methods and systems are provided for increasing energy output from Z-pinch and other plasma confinement systems. In one example, a system may include memory storing instructions that, if executed by one or more processors, cause the system to adjust one or more parameters to generate a magnetic field which is sufficiently strong to axially compress a fuel gas to induce thermonuclear fusion and increase a fusion energy gain factor greater than a fusion energy gain factor limit attainable by the thermonuclear fusion. In certain examples, adjusting the one or more parameters may include adjusting a duty cycle of a discharge current applied to the fuel gas based, at least in part, on an amount of thermal collisions between fusion byproducts and the fuel gas. In certain examples, by adjusting the duty cycle, the magnetic field may be adjusted to induce or increase the thermal collisions. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/510456 |
| CURRENT CPC | Fusion Reactors G21B 1/05 (20130101) G21B 1/21 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/3266 (20130101) Original (OR) Class H01J 37/32064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240206790 | Lubold |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| INVENTOR(S) | Nichola Lubold (Phoenix, Arizona) |
| ABSTRACT | Systems and methods are provided for detecting physiological episodes (PE). Raw physiological data including raw respiration data is received from at least one sensor of a biosensing garment of a pilot. Individual breaths are extracted from the raw physiological data. Each individual breath has an associated breath pattern. Aircraft environment data associated with an aircraft is received. The individual breaths are aligned with the aircraft environment data in accordance with a breath timeline associated with the individual breaths is and an aircraft environment timeline associated with the aircraft environment data. Each individual breath is classified as one of a plurality of different breath types based on the associated breath pattern. A determination is made regarding whether the breath types associated with the individual breaths are associated with a PE profile based at least in part on the aircraft environment data. A PE alert is issued based on the determination. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/145544 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) Original (OR) Class A61B 5/02405 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207248 | PESTELL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BARUCH S. BLUMBERG INSTITUTE (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard G. PESTELL (Fort Lauderdale, Florida); Yanming DU (Cheshire, Connecticut) |
| ABSTRACT | Described herein are methods for administering a chemotherapeutic agent to a patient in need thereof. Such methods may treat, prevent, or ameliorate tumor CIN associated with administration of a chemotherapeutic agent, resulting in therapeutic resistance, tumor progression and death also described are kits and compositions useful to implement the methods. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 18/287988 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/4741 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207376 | SIEGEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin SIEGEL (Seattle, Washington); David BAKER (Seattle, Washington); Sydney Rin Anna GORDON (Seattle, Washington); Ingrid Swanson PULTZ (Seattle, Washington); Elizabeth Joy STANLEY (Bothell, Washington); Sarah Jane WOLF (Camas, Washington) |
| ABSTRACT | The invention provides compositions and methods for treating celiac sprue. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/513879 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/48 (20130101) A61K 38/482 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Enzymes C12Y 304/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207386 | RICKE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell O. RICKE (Winchester, Massachusetts) |
| ABSTRACT | Provided herein are universal prophylactic compositions for preventing infection with influenza viruses by directing the immune response to highly conserved regions of the virus. Also provided are universal therapeutic compositions for treating influenza infection by targeting the highly conserved regions. Methods for using the prophylactic and therapeutic compositions are also provided. |
| FILED | Tuesday, March 21, 2023 |
| APPL NO | 18/187133 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/16 (20130101) A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207508 | Rivnay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois); WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Rivnay (Chicago, Illinois); Omid Veiseh (Bellaire, Texas); Jacob Robinson (Houston, Texas); Samantha T. Fleury (Houston, Texas); Matthew C. Parker (Houston, Texas); Fatima T. Alrashdan (Houston, Texas) |
| ABSTRACT | A bioelectronic implantable device includes engineered cells and an electronically controlled stimulator that regulates a quantity and timing of therapeutic agent produced by the engineered cells. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 18/287671 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) A61M 5/14276 (20130101) Original (OR) Class A61M 2205/3306 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207820 | Strathmann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLORADO SCHOOL OF MINES (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy J. Strathmann (Golden, Colorado); Christopher P. Higgins (Golden, Colorado); Ori Soker (Lakewood, Colorado); Shilai Hao (Lakewood, Colorado) |
| ABSTRACT | Herein disclosed are compositions, methods, and systems useful for treating PFAS- contaminated adsorbents to simultaneously achieve mineralization of adsorbed per- and polyfluoroalkyl substances and regenerate the adsorbent materials to enable re-use of the materials. This is accomplished by applying subcritical hydrothermal reaction conditions together with solution amendments to promote PFAS destruction while minimizing alterations of the adsorbent materials. The process requires much lower energy input than existing thermal disposal or regeneration technologies. The milder liquid phase treatment conditions allow for treatment and regeneration of a wider range of adsorbent materials being deployed for PFAS treatment. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479419 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/20 (20130101) B01J 20/3416 (20130101) B01J 20/3475 (20130101) Original (OR) Class B01J 20/3483 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/283 (20130101) C02F 2101/36 (20130101) C02F 2303/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207923 | Boyle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Bret M. Boyle (Pittsburgh, Pennsylvania); Cynthia Kutchko (Pittsburgh, Pennsylvania); Bryan W. Wilkinson (Pittsburgh, Pennsylvania); Jacob M. Kupas (Pittsburgh, Pennsylvania); Kerianne M. Dobosz (Pittsburgh, Pennsylvania) |
| ABSTRACT | Reactive additive manufacturing compositions with low amounts of noncombustible materials are provided, as well as methods of making and using the compositions. The compositions comprise two or more reactive components and a filler. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 18/556905 |
| CURRENT CPC | Foundry Moulding B22C 7/02 (20130101) Original (OR) Class B22C 9/04 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/314 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2001/12 (20130101) B29K 2005/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208436 | Gutenberger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oshkosh Corporation (Oshkosh, Wisconsin) |
| ASSIGNEE(S) | Oshkosh Corporation (Oshkosh, Wisconsin) |
| INVENTOR(S) | Ryan Gutenberger (Rochester, Minnesota); Ryan Rowe (Oshkosh, Wisconsin) |
| ABSTRACT | A cable holder for a vehicle comprising a body portion defining an engagement surface and a plurality of holes, and a first hook, a second hook, and a third hook, wherein the first hook, the second hook, and the third hook each define a curved engagement surface. The first hook, the second hook, and the third hook are configured to receive a cable to removably couple the cable with the cable holder by engaging an exterior surface of the cable at the curved engagement surface, where the first hook, the second hook, and the third hook are manufactured from a flexible material such that the cable breaks away from the cable holder when a first force is exerted on the cable to pull the cable away from the cable holder without transferring a second force to a component of the vehicle that the cable holder is coupled to. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541717 |
| CURRENT CPC | Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 16/0215 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208876 | Downs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| INVENTOR(S) | John Downs (Morris Plains, New Jersey); Kevin S. Blinn (Morris Plains, New Jersey); Bahram Jadidian (Morris Plains, New Jersey); Mehrad Mehr (Morris Plains, New Jersey) |
| ABSTRACT | Components and methods for producing such components are provided. The component comprises a substrate having a ceramic material, and a coating system on a surface of the substrate. The coating system includes one or more layers defining a composition gradient. A first portion of the coating system closest to the surface of the substrate has a composition comprising at least 95 wt. % of a rare earth disilicate, a second portion of the coating system furthest from the surface of the substrate has a composition comprising at least 50 wt. % of a rare earth monosilicate, and a third portion between the first portion and the second portion has a composition comprising both the rare earth disilicate and the rare earth monosilicate. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/146545 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 41/009 (20130101) C04B 41/52 (20130101) C04B 41/0072 (20130101) C04B 41/89 (20130101) C04B 41/4539 (20130101) C04B 41/5024 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208940 | JI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haitao JI (Tampa, Florida) |
| ABSTRACT | Described herein are small molecule inhibitors of the β-catenin/B-cell lymphoma 9 interaction and pharmaceutical compositions including a therapeutically effective amount of the small molecule inhibitors described herein. Described are also methods of treating oncological disorders, for example cancer by administering the small molecule inhibitors of the β-catenin/B-cell lymphoma interaction described herein. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 18/556241 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/4545 (20130101) A61K 47/55 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 409/14 (20130101) C07D 471/10 (20130101) C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208946 | Glover et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Alabama (Mobile, Alabama) |
| ASSIGNEE(S) | University of South Alabama (Mobile, Alabama) |
| INVENTOR(S) | Thomas Grant Glover (Spanish Fort, Alabama); Kevin N. West (Mobile, Alabama) |
| ABSTRACT | Processes for chemical functionalization of materials are described. The processes generally include chemical reaction between a thiol group of a first compound or material and an alkene group or alkyne group of a second compound or material. Also disclosed are functionalized materials and compounds suitable for functionalizing a material. |
| FILED | Thursday, March 07, 2024 |
| APPL NO | 18/599048 |
| CURRENT CPC | Heterocyclic Compounds C07D 233/74 (20130101) C07D 251/40 (20130101) C07D 403/12 (20130101) Original (OR) Class Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 13/165 (20130101) D06M 13/348 (20130101) D06M 2101/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209059 | Tran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Eric Tran (Portland, Oregon); Yong-Chen Lu (Little Rock, Arkansas); Anna Pasetto (Asker, Norway); Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland); Zhili Zheng (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/423020 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/82 (20130101) C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) G01N 2333/7051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209235 | Glass et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Setex Technologies, Inc. (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Setex Technologies, Inc. (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Paul Samuel Glass (Pittsburgh, Pennsylvania); Aimee L. DeLuca (Pittsburgh, Pennsylvania); Burak Aksak (Pittsburgh, Pennsylvania) |
| ABSTRACT | An adhesive material providing permeation-resistant characteristics, wherein the material comprises a surface having a plurality of microstructures interspersed with at least one ridge. The ridge is adapted to make continuous contact with a mating surface. In one embodiment, the ridge is linear. In an alternative embodiment, the ridge has a square pattern forming a mesh on the surface. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/909798 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/00 (20130101) Original (OR) Class C09J 2301/31 (20200801) C09J 2301/206 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209302 | Hernandez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Jonathan Matthew Hernandez (Bethesda, Maryland); Thomas J. Pohida (Bethesda, Maryland); Marcial Antonio Garmendia (Bethesda, Maryland); Samantha Marilyn Ruff (Bethesda, Maryland); Michael Martin Wach (Bethesda, Maryland); Shreya Gupta (Bethesda, Maryland); James McDonald (Bethesda, Maryland); Kirsten Remmert (Bethesda, Maryland); Alexander Joseph Rossi (Bethesda, Maryland) |
| ABSTRACT | Ex vivo analysis can be performed by mounting a portion of live tissue resected from a patient on a sample platform. Using the sample platform, the resected tissue portion can be positioned within a perfusion chamber. Perfusate is flowed through the perfusion chamber and into contact with the resected tissue portion such that diffusion of oxygen occurs between the perfusate and the resected tissue portion. During the flowing, the resected tissue portion maintains a competent immune system. Drugs can be added to the perfusate flow to ascertain the effect on the tissue. The sample platform is designed to be removable from the perfusion chamber for analysis of the tissue by imaging or other investigation techniques, for experimental treatment, or for any other purpose. After removal, the sample platform can be returned to the perfusion chamber for continued viability of the tissue. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/910911 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 29/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209421 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mammoth Biosciences, Inc. (Brisbane, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janice Sha CHEN (San Francisco, California); Carley Gelenter HENDRIKS (Burlingame, California); Clare Louise FASCHING (Redwood City, California); Xin MIAO (Mountain View, California); Nazmiye Emel ALPAY (Mountain View, California); James Paul BROUGHTON (South San Francisco, California); Elizabeth M. HAWKINS (Redwood City, California); Matthew S. VEROSLOFF (South San Francisco, California); Sophia HUBBELL (San Francisco, California); Sarah Jane SHAPIRO (Pacifica, California); Lior KREINDLER (Foster City, California); Jesus CHING (Saratoga, California) |
| ABSTRACT | The present disclosure provides single-buffer systems that enable efficient and rapid amplification and programmable nuclease enzyme mediated reactions. The single-buffer systems and reagent compositions therein may be used for assaying for a nucleic acid sequence from a sample. |
| FILED | Tuesday, June 13, 2023 |
| APPL NO | 18/334320 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) C12Q 1/485 (20130101) C12Q 1/6823 (20130101) Original (OR) Class C12Q 1/6844 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/922 (20130101) G01N 2333/9126 (20130101) G01N 2333/9128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209492 | Ehrenberg |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isaac Mayer Ehrenberg (Brookline, Massachusetts) |
| ABSTRACT | Systems and methods for producing electromagnetic devices are provided. The systems and methods allow for an electromagnetic device having both a substrate (e.g., polymer) and conductive material (e.g., metal) to be manufactured without using masks or other outside objects disposed over a surface (e.g., the substrate) onto which the conductive material is deposited. In one exemplary embodiment, the method includes performing additive manufacturing using a polymer to produce a device having a plurality of interconnected walls and a plurality of frequency selective surface elements, and then coating portions of the device with a conductive material. A plurality of shadowing features are formed as part of one or more of the walls to protect the frequency selective surface elements from being coated by the conductive material. Other methods, and a variety of systems that can result from the disclosed methods, are also provided. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/382926 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/20 (20130101) Original (OR) Class C23C 14/044 (20130101) Antennas, i.e Radio Aerials H01Q 15/0013 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 3/146 (20130101) H05K 3/1258 (20130101) H05K 2201/09036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209498 | Quayle |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Great Lakes Crystal Technologies, Inc. (East Lansing, Michigan) |
| ASSIGNEE(S) | Great Lakes Crystal Technologies, Inc. (East Lansing, Michigan) |
| INVENTOR(S) | Paul Connolly Quayle (East Lansing, Michigan) |
| ABSTRACT | A method of growing a single crystal diamond material synthesized using a homoepitaxial chemical vapor deposition process. The method includes the steps of placing a free-standing diamond starting seed substrate on a substrate holder within a reaction chamber for chemical vapor deposition; feeding a process gas into the reaction chamber, the process gas including hydrogen gas; igniting a plasma within the reaction chamber to activate the process gas by adjusting the substrate temperature to increase to a first target substrate temperature; adding a carbon-containing gas to the process gas once the substrate temperature is at or near the first target substrate temperature to initiate diamond growth; and adjusting the substrate temperature to a second target substrate temperature that is different from the first target substrate temperature during the diamond growth. |
| FILED | Tuesday, December 26, 2023 |
| APPL NO | 18/396504 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/52 (20130101) C23C 16/276 (20130101) Original (OR) Class C23C 16/277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209552 | King et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Propel, LLC (Pawtucket, Rhode Island) |
| ASSIGNEE(S) | Propel, LLC (Pawtucket, Rhode Island) |
| INVENTOR(S) | Clare King (Providence, Rhode Island); Anjali Khemani (Providence, Rhode Island); Birgit Leitner (Providence, Rhode Island) |
| ABSTRACT | A machine knittable hybrid yarn is disclosed. The hybrid yarn includes one or more electrically non-conductive yarns and two or more electrically conductive wires wrapped around the electrically non-conductive yarns. The electrically conductive wires have an exterior layer of an insulated material. The electrically non-conductive yarns include a majority fraction of an overall cross-section of the hybrid yarn. The two or more electrically conductive wires are wrapped around the one or more electrically non-conductive yarns at between 1 and 15 twists per inch. The one or more electrically non-conductive yarns are 1500 denier or finer. |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/419869 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/25 (20210101) A61B 5/27 (20210101) A61B 5/6804 (20130101) A61B 2562/14 (20130101) Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/12 (20130101) D02G 3/36 (20130101) Original (OR) Class D02G 3/045 (20130101) D02G 3/047 (20130101) D02G 3/441 (20130101) D02G 3/443 (20130101) Woven Fabrics; Methods of Weaving; Looms D03D 1/0088 (20130101) Knitting D04B 1/12 (20130101) D04B 1/126 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2211/02 (20130101) D10B 2401/16 (20130101) D10B 2403/02431 (20130101) D10B 2501/00 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/038 (20130101) H05K 2201/0281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209759 | SCHOCK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); Mid Michigan Research, LLC (Brighton, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); Mid Michigan Research, LLC (Brighton, Michigan) |
| INVENTOR(S) | Harold J. SCHOCK (Brighton, Michigan); Thomas R. STUECKEN (Eagle, Michigan); Jennifer HIGEL (Hayesville, North Carolina); Gary HUNTER (Dexter, Michigan) |
| ABSTRACT | An internal combustion engine includes a camshaft operably adjusted by a phaser. Another aspect includes an internal combustion engine having an actuation system for an air valve. A further aspect provides a camshaft-in-camshaft system with a cam phaser located adjacent opposite ends. In another aspect, an internal combustion engine apparatus includes multiple nested camshafts with one of the camshafts having a cam configured to actuate an air intake valve associated with a turbulent jet ignition prechamber, and another of the camshafts having a cam configured to actuate an air valve of a main piston combustion chamber, the nested camshafts being independently rotatable by separate electromagnetic actuators. |
| FILED | Wednesday, January 24, 2024 |
| APPL NO | 18/420997 |
| CURRENT CPC | Cyclically Operating Valves for Machines or Engines F01L 1/022 (20130101) F01L 13/0036 (20130101) Original (OR) Class F01L 2001/0537 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209795 | Heeter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Heeter (Indianapolis, Indiana); Daniel E. Molnar, JR. (Indianapolis, Indiana); Kathryn A. Sontag (Indianapolis, Indiana); Michael G. Meyer (Indianapolis, Indiana) |
| ABSTRACT | A gas turbine engine comprises a primary fan and an engine core. The primary fan is mounted for rotation about an axis of the gas turbine engine to provide thrust. The engine core is coupled to the primary fan and configured to drive the primary fan about the axis to cause the fan to push air to provide thrust for the gas turbine engine. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/088974 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 31/06 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/06 (20130101) F02C 9/20 (20130101) Original (OR) Class Jet-propulsion Plants F02K 3/04 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2260/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209796 | Heeter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Heeter (Indianapolis, Indiana); Daniel E. Molnar, Jr. (Indianapolis, Indiana); Kathryn A. Sontag (Indianapolis, Indiana); Michael G. Meyer (Indianapolis, Indiana) |
| ABSTRACT | A gas turbine engine comprises a primary fan and an engine core. The primary fan is mounted for rotation about an axis of the gas turbine engine to provide thrust. The engine core is coupled to the primary fan and configured to drive the primary fan about the axis to cause the fan to push air to provide thrust for the gas turbine engine. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/088994 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) F02C 6/00 (20130101) F02C 9/20 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2220/70 (20130101) F05D 2270/05 (20130101) F05D 2270/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210350 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Steve S Kim (DAyton, Ohio); Rajesh Naik (Centerville, Ohio); Claude C Grigsby (Beavercreek, Ohio); Jennifer A. Martin (Beavercreek, Ohio); Michael Brothers (Lebanon, Ohio); Yen H Ngo (Springfield, Ohio) |
| ABSTRACT | Disclosed is a selective chemical sensor, methods of production, and methods of use, where the sensor utilizes an electrochemical sensor element protected by a semi-selective polymeric matrix in conjunction with a selecting compound doped into the matrix along with an acid or base. The polymeric matrix serves as an analyte capture matrix, while the selecting compound reacts with the analyte, further improving the selectivity of the sensor. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/423977 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4141 (20130101) Original (OR) Class G01N 27/4146 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210576 | Joannopoulos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Technion-Israel Institute Of Technology (Haifa, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Joannopoulos (Belmont, Massachusetts); Steven Johnson (Arlington, Massachusetts); Marin Soljacic (Belmont, Massachusetts); Steven Kooi (Lexington, Massachusetts); Justin Beroz (Cambridge, Massachusetts); Ido Kaminer (Haifa, Israel); Nicholas Rivera (Somerville, Massachusetts); Yi Yang (Cambridge, Massachusetts); Charles Roques-Carmes (Cambridge, Massachusetts); Ali Ghorashi (Boston, Massachusetts); Zin Lin (Boston, Massachusetts); Nicolas Romeo (Somerville, Massachusetts) |
| ABSTRACT | Methods and systems are disclosed that enhance the yield and speed of emission and control the spectral and angular emission of light emitted by materials under irradiation by high-energy particles through a process known as scintillation. In each case, a photonic structure (of nano- or micron-scale feature sizes) is integrated with a scintillating material, and the photonic structure enhances the yield or controls the spectrum of the material. Various embodiments of this technology and practical demonstrations are disclosed. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 18/286808 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/04 (20130101) G01N 23/083 (20130101) G01N 23/2251 (20130101) Measurement of Nuclear or X-radiation G01T 1/2018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210625 | Bose et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Debapam Bose (Oakland, California); Jiawei Wang (Goleta, California); Daniel J. Blumenthal (Santa Barbara, California) |
| ABSTRACT | Disclosed herein is methods for fabricating ultra-low loss waveguides. One particular method may include: preparing a substrate including a lower cladding layer in a deposition chamber; flowing precursors including deuterated silane and nitrogen onto the lower cladding layer in the deposition chamber; subjecting the precursors to an inductively coupled plasma-plasma enhanced chemical vapor deposition (ICP-PECVD) process which disassociates the deuterated silane and nitrogen and deposits waveguide material of silicon nitride or silicon oxynitride onto the lower cladding layer; patterning the waveguide material into a patterned waveguide material; and depositing a top cladding layer on the patterned waveguide material, wherein the ICP-PECVD process occurs at a temperature less than or equal to 250° C. Advantageously, the ICP-PECVD process allows for deposition of low hydrogenated deposition of material layers which may allow for low temperature fabrication of ultra-low loss waveguides. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/395038 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/401 (20130101) Optical Elements, Systems, or Apparatus G02B 6/136 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210786 | Gausmann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| INVENTOR(S) | Stefan Gausmann (Orlando, Florida); Axel Schulzgen (Orlando, Florida) |
| ABSTRACT | The discovery of a clear correlation between the Anderson localization length and the dispersion properties of highly localized TALOF modes allowed us to demonstrate that the zero dispersion wavelength can be tuned over more than 300 nm within the same fiber by selected excitation of specific modes. This enabled apparatus and methods for generating tunable, multi-octave-spanning supercontinuum (SC) spectra in a bandwidth from 460 nm to 1750 nm. Associated applications are also presented. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 18/556963 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/3528 (20210101) Original (OR) Class G02F 1/3551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240211134 | Kalamatianos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | John Kalamatianos (Arlington, Massachusetts); Karthik Ramu Sangaiah (Seattle, Washington); Anthony Thomas Gutierrez (Seattle, Washington) |
| ABSTRACT | A memory controller includes an arbiter, a vector arithmetic logic unit (VALU), a read buffer and a write buffer both coupled to the VALU, and an atomic memory operation scheduler. The VALU performs scattered atomic memory operations on arrays of data elements responsive to selected memory access commands. The atomic memory operation scheduler is for scheduling atomic memory operations at the VALU; identifying a plurality of scattered atomic memory operations with commutative and associative properties, the plurality of scattered atomic memory operations on at least one element of an array of data elements associated with an address; and commanding the VALU to perform the plurality of scattered atomic memory operations. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/087964 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/061 (20130101) Original (OR) Class G06F 3/0656 (20130101) G06F 3/0659 (20130101) G06F 3/0673 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240211407 | Kalamatianos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | John Kalamatianos (Arlington, Massachusetts); Jagadish B. Kotra (Austin, Texas); Asmita Pal (Madison, Wisconsin) |
| ABSTRACT | A memory request issue counter (MRIC) is maintained that is incremented for every memory access a central processing unit core makes. A region reuse distance table is also maintained that includes multiple entries each of which stores the region reuse distance for a corresponding region. When a memory access request for a physical address is received, a reuse distance for the physical address is calculated. This reuse distance is the difference between the current MRIC value and a previous MRIC value for the physical address. The previous MRIC value for the physical address is the MRIC value the MRIC had when a memory access request for the physical address was last received. A region reuse distance for a region that includes the physical address is generated based on the reuse distance for the physical address and used to manage the cache. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/146883 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0888 (20130101) Original (OR) Class G06F 2212/1016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240211536 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Shuo-Wei CHEN (Los Angeles, California); Rezwan RASUL (Los Angeles, California) |
| ABSTRACT | A compute in-memory architecture comprising multiple neurons is provided. Each neuron includes one or more storage compute cells, each of which includes a logic circuit configured to receive a multi-bit input and a weight. The weight is defined by one or more weight bits. The logic circuit is further configured to output a control voltage corresponding to logic ‘HIGH’ when XNOR operation between an input sign bit and a corresponding weight bit is 1 and a corresponding input magnitude bit is also 1. A first digital-to-analog converter is formed from a first MOSCAP group in electrical communication with the logic circuit. The first MOSCAP group includes a total number of MOSCAPs equal to input magnitude bit resolution times weight bit resolution. Characteristically, each MOSCAP in the first MOSCAP group has a first end that receives the control voltage, and a second end in electrical communication with a first summation line. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 18/288168 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240211618 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adrian Tang (New York, New York); Salvatore Stolfo (New York, New York); Lakshminarasimhan Sethumadhavan (New York, New York) |
| ABSTRACT | Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method that includes determining whether an operation to access a memory location containing executable code comprises a general-purpose memory access operation, and changing content of the memory location in response to a determination that the operation to access the memory location containing the executable code comprises the general-purpose memory access operation to the memory location. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/386504 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) G06F 12/1009 (20130101) G06F 12/1475 (20130101) G06F 21/52 (20130101) G06F 21/604 (20130101) G06F 21/6218 (20130101) Original (OR) Class G06F 2009/45583 (20130101) G06F 2009/45595 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240211771 | Bathe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Bathe (Cambridge, Massachusetts); Sakul Ratanalert (Baltimore, Maryland); Remi Veneziano (Manassas, Virginia); James Banal (Cambridge, Massachusetts); Tyson Shepherd (Louisville, Colorado) |
| ABSTRACT | Methods for controlled segregation of blocks of information encoded in the sequence of a biopolymer, such as nucleic acids and polypeptides, with rapid retrieval based on multiply addressing nanostructured data have been developed. In some embodiments, sequence controlled polymer memory objects include data-encoded biopolymers of any length or form encapsulated by natural or synthetic polymers and including one or more address tags. The sequence address labels are used to associate or select memory objects for sequencing read-out, enabling organization and access of distinct memory objects or subsets of memory objects using Boolean logic. In some embodiments, a memory object is a single-stranded nucleic acid scaffold strand encoding bit stream information that is folded into a nucleic acid nanostructure of arbitrary geometry, including one or more sequence address labels. Methods for controlled degradation of biopolymer-encoded blocks of information in the memory objects are also developed. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/589141 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2563/149 (20130101) C12Q 2563/185 (20130101) Electric Digital Data Processing G06F 12/0646 (20130101) G06F 2212/251 (20130101) Computer Systems Based on Specific Computational Models G06N 3/123 (20130101) Original (OR) Class Static Stores G11C 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212328 | Loo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Noel Loo (Cambridge, Massachusetts); Ramin Hasani (New York, New York); Alexander A. Amini (Brookline, Massachusetts); Daniela Rus (Weston, Massachusetts) |
| ABSTRACT | Dataset distillation compresses large datasets into smaller synthetic coresets that retain performance with the aim of reducing storage and computational burdens of processing an original, entire dataset. The present disclosure provides an improved algorithm that uses a non-deterministic feature approximation of neural network Gaussian process (NNGP) kernels, or other trained kernels, that reduces a kernel matrix computation to O(|S|). When combined with a modified Platt scaling loss, the disclosed algorithm can provide at least a 100-fold speedup over a Kernel-Inducing Points (KIP) algorithm and can run on a single graphics processing unit. The disclosed Random Feature Approximation Distillation (RFAD) algorithm can perform competitively with other dataset condensation algorithms in accuracy over a range of large-scale datasets, both in kernel regression and finite-width network training. The disclosed techniques can be effective on tasks such as model interpretability and data privacy preservation. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/199825 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/774 (20220101) Original (OR) Class G06V 10/776 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212514 | Drexler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Robert Drexler (San Diego, California); Stephen Hammel (Lakeside, California); John Stephen deGrassie (San Diego, California); Benjamin Joel Laxton (San Diego, California) |
| ABSTRACT | A light-guided vehicle comprising: a platform; an optical sensor mounted to the platform, wherein the optical sensor is configured to image off-axis scatter of a photon beam; a processing unit mounted to the platform, wherein the processing unit is communicatively coupled to the platform and to the optical sensor, and wherein the processing unit is configured to monitor intensities of off-axis photons that are scattered by aerosol particles in a beam propagation path as measured by the optical sensor, and wherein the processing unit is further configured to maintain the platform within a vehicle path based on the monitored off-axis-photon intensities, wherein the vehicle path is offset from, and parallel to, the propagation path. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/087503 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 20/17 (20220101) Traffic Control Systems G08G 5/0069 (20130101) Original (OR) Class G08G 5/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212542 | MOULTON, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | JRM Enterprises, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Russ MOULTON, Jr. (Orlando, Florida); Steve BUTRIMAS (Orlando, Florida); Christopher FINK (Orlando, Florida); Dan BYBEE (Orlando, Florida); Isaac EHLERS (Orlando, Florida); William HILTON (Orlando, Florida) |
| ABSTRACT | A dynamic infrared (IR) scene generation system comprising a thin-film screen configured to react to contact by an IR laser; a laser scanning system configured to contact the thin-film screen with laser beam, the laser scanning system comprising a laser scanner, one or more modulators, and an IR laser source; and an image processing system operably connected to a controller configured to control the laser scanning system based on data from the image processing system, wherein the laser scanning system can be configured to contact the thin-film screen with the IR laser based on an IR scene input. |
| FILED | Wednesday, August 09, 2023 |
| APPL NO | 18/447106 |
| CURRENT CPC | Weapon Sights; Aiming F41G 3/165 (20130101) Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213008 | Campbell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Spark Thermionics, Inc. (Berkeley, California); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Campbell (Philadelphia, Pennsylvania); Mohsen Azadi (Philadelphia, Pennsylvania); Kyana Van Houten (Berkeley, California); Jared William Schwede (Berkeley, California); Samuel M. Nicaise (Philadelphia, Pennsylvania); Igor Bargatin (Wynnewood, Pennsylvania) |
| ABSTRACT | A small-gap device system, preferably including two or more electrodes and one or more spacers maintaining a gap between two or more of the electrodes. A spacer for a small-gap device system, preferably including a plurality of legs defining a mesh structure. A method of spacer and/or small-gap device fabrication, preferably including: defining lateral features, depositing spacer material, selectively removing spacer material, separating the spacer from a fabrication substrate, and/or assembling the small-gap device. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/244034 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 9/185 (20130101) H01J 45/00 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/6653 (20130101) H01L 29/6656 (20130101) Electric solid-state devices not otherwise provided for H10N 10/00 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213392 | NAVEH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bar-Ilan University (Ramat Gan, Israel); Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Doron NAVEH (Petah-Tikva, Israel); Fengnian XIA (Orange, Connecticut); Shaofan YUAN (New Haven, Connecticut) |
| ABSTRACT | Apparatuses and methods are provided for reconstructing a spectrum of an incident source. An example apparatus includes a photodetection layer, a voltage source, and a voltage drain. In some embodiments, the example apparatus further includes one or more gate electrodes. The photodetection layer includes one or more photodetection materials and is configured to generate a photoresponse vector in response to an incident source and/or gate electrodes. The voltage source and voltage drain are electrically connected to the photodetection layer and are configured to measure the photoresponse vector generated by the photodetection layer. The spectrum of the unknown incidence light can be reconstructed by using the photoresponse vector and the pre-measured response matrix. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 18/557008 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/28 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1136 (20130101) Original (OR) Class H01L 31/02327 (20130101) H01L 31/035236 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213593 | Evans et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aspen Aerogels, Inc. (Northborough, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Owen Evans (Chelmsford, Massachusetts); Nicholas Zafiropoulos (Wayland, Massachusetts); Shannon White (Hudson, Massachusetts); Wenting Dong (Marlborough, Massachusetts); Wendell Rhine (Belmont, Massachusetts) |
| ABSTRACT | The present invention provides a fiber-reinforced aerogel material which can be used as insulation. The fiber-reinforced aerogel material is highly durable, flexible, and has a thermal performance that exceeds the insulation materials currently used. The fiber-reinforced aerogel insulation material can be as thin as 1 mm or less, and can have a thickness variation as low as 2% or less. Also provided is a method for improving the performance of a battery by incorporating a reinforced aerogel material into the battery. Further provided is a casting method for producing thin fiber-reinforced aerogel materials. |
| FILED | Monday, December 04, 2023 |
| APPL NO | 18/528371 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0091 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 6/36 (20130101) H01M 6/5072 (20130101) H01M 50/116 (20210101) H01M 50/117 (20210101) H01M 50/121 (20210101) H01M 50/122 (20210101) H01M 50/124 (20210101) H01M 50/131 (20210101) H01M 50/133 (20210101) H01M 50/138 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213682 | Zekios et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Constantinos L. Zekios (Miami, Florida); Stavros Georgakopoulos (Miami, Florida); Nicholas E. Russo (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Constantinos L. Zekios (Miami, Florida); Stavros Georgakopoulos (Miami, Florida); Nicholas E. Russo (Miami, Florida) |
| ABSTRACT | Multi-band, microstrip patch antennas, as well as methods of fabricating the same and methods of using the same, are provided. A decoupling technique can be used where strategically etched slots are provided between the tightly coupled microstrip patch antennas, and the appropriate mode excitation of the corresponding patch antennas can be used. The antennas have high isolation between the frequency bands of operation. Multi-band operation can be achieved by exciting a different mode on each contiguous portion of the patch antenna. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/810889 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 5/378 (20150115) H01Q 9/0421 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213688 | Hamza et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Muhammad Hamza (Miami, Florida); Stavros Georgakopoulos (Miami, Florida); Constantinos L. Zekios (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Muhammad Hamza (Miami, Florida); Stavros Georgakopoulos (Miami, Florida); Constantinos L. Zekios (Miami, Florida) |
| ABSTRACT | Ultra-wideband (UWB) arrays that are fully planar are provided. Fully-planar inverted-L element (FILE) arrays that are tightly coupled arrays (TCAs) can realize UWB tightly coupled apertures in the W and higher millimeter wave (mmWave) bands. The unit cell architecture of the FILE array, (which can have any desired size, can be comprised of an inverted-L shaped antenna and a capacitively coupled via-fence. |
| FILED | Wednesday, May 10, 2023 |
| APPL NO | 18/315006 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 9/30 (20130101) Original (OR) Class H01Q 9/285 (20130101) H01Q 21/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
20240207186 — NANOLIPOPROTEIN PARTICLES AND RELATED COMPOSITIONS METHODS AND SYSTEMS FOR LOADING RNA
| US 20240207186 | KAMRUD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kurt I. KAMRUD (San Diego, California); Nathaniel S. WANG (San Diego, California); Martina FELDERMAN (La Jolla, California); Bolyn HUBBY (Redwood City, California); Heather D, GOUVIS (San Diego, California); Nicholas O. FISCHER (Livermore, California); Matthew A. COLEMAN (Oakland, California); Angela Clare EVANS (Livermore, California); Wei HE (Davis, California); Amy RASLEY (Livermore, California); Craig D. BLANCHETTE (San Leandro, California) |
| ABSTRACT | Nanolipoprotein particles comprising at least a scaffold protein component and a membrane lipid component and related complexes, compositions, methods and systems are described, in which the membrane lipid component comprises at least one or more membrane forming lipids and one or more cationic lipids. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/422810 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 9/1274 (20130101) A61K 47/6917 (20170801) A61K 48/0008 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207780 | Warsinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Elan Martin Warsinger (Carmel, Indiana); James Edward Braun (West Lafayette, Indiana); Davide Ziviani (West Lafayette, Indiana); Andrew Fix (Ballwin, Missouri); Jinwoo Oh (West Lafayette, Indiana) |
| ABSTRACT | A method of drying, including the steps of loading a mass to be dried into a drying volume, circulating air from the drying volume into a first membrane module, circulating moist air from the first membrane module to a second membrane module and circulating dried air from the first membrane module to a condenser, circulating moist air from the second membrane module to an evaporator, draining condensate from the evaporator, circulating moist air from the condenser to the evaporator, circulating heated dry air from the evaporator to the condenser, and circulating heated dry air from the condenser to the drying volume. Each respective membrane module defines an enclosure bisected by water permeable membrane for extracting water from moist air circulated therethrough. A method of passive dehumidification using hollow fiber membranes, including a quasi-counter flow effectiveness model, a partial pressure-driven ε-NTU method for mass transfer, sensitivity analysis comparing module geometries and membrane properties, optimized form factors, and scalability design guidelines. A method of active dehumidification in the form of dual-module humidity pump, including two membranes to restrict pressure ratio, a variable-speed water vapor compressor, a variable-speed vacuum pump, three-way valves for reversed air flow, and a backwash mode operation for membrane fouling prevention. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/542055 |
| CURRENT CPC | Separation B01D 53/226 (20130101) B01D 53/265 (20130101) B01D 53/268 (20130101) Original (OR) Class B01D 2053/224 (20130101) B01D 2257/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207807 | Locke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce R. Locke (Tallahassee, Tennessee); Robert J. Wandell (Tallahassee, Florida); Radha Krishna Bulusu Raja (Tallahassee, Florida) |
| ABSTRACT | A method of conducting reactions utilizing a gas/liquid/plasma reactor includes the steps of providing a gas/liquid/plasma reactor, providing a liquid and a gas defining a gas/liquid interface within the gas/liquid/plasma reactor, and charging the liquid and gas inside the gas/liquid/plasma reactor. The charging includes the application of a voltage to electrodes and thereby to the liquid and gas which includes a series of voltage bursts having an outer burst pulse frequency. The bursts each include a series of voltage pulses having an inner burst pulse frequency. The electrodes can be oriented such that a plasma is propagated across the gas/liquid interface when the voltage pulses are applied. A system for conducting reactions utilizing a gas/liquid/plasma reactor is also disclosed. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506745 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/088 (20130101) Original (OR) Class B01J 2219/0869 (20130101) Non-metallic Elements; Compounds Thereof; C01B 15/0295 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207899 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sortera Technologies, Inc. (Markle, Indiana) |
| ASSIGNEE(S) | Sortera Technologies, Inc. (Markle, Indiana) |
| INVENTOR(S) | Nalin Kumar (Fort Wayne, Indiana); Manuel Gerardo Garcia, Jr. (Austin, Texas); Isha Kamleshbhai Maun (Arlington, Texas) |
| ABSTRACT | A material sorting system sorts materials utilizing an x-ray fluorescence and/or a vision system that implements a machine learning system in order to identify or classify each of the materials, which are then sorted into separate groups based on such an identification or classification determining that the materials are composed of either wrought aluminum, extruded aluminum, or cast aluminum. The system is capable of sorting between cast aluminum alloys and also between wrought aluminum alloys. |
| FILED | Monday, January 15, 2024 |
| APPL NO | 18/412978 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207914 | ERICKSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); UNIVERSITY OF PORTSMOUTH (Portsmouth, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erika Marie ERICKSON (Golden, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); Japheth Emi GADO (Golden, Colorado); John E. MCGEEHAN (Portsmouth, United Kingdom); Christina Marie PAYNE (Arlington, Virginia) |
| ABSTRACT | Disclosed herein are PET hydrolase enzymes, and their nucleic acid and amino acid sequences. A number of candidates have been identified with detectable, quantifiable activity on PET and these enzymes possess desirable traits that are leveraged in the design and engineering of enzyme formulations targeted to degrade specific polymers. These enzymes have measurable PET degrading activity and, in an embodiment, may be active polyester polyurethanes. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/556064 |
| CURRENT CPC | Disposal of Solid Waste B09B 3/60 (20220101) Original (OR) Class B09B 2101/75 (20220101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/18 (20130101) C12N 15/70 (20130101) Enzymes C12Y 301/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208661 | Alahyari |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abbas A. Alahyari (Glastonbury, Connecticut) |
| ABSTRACT | A system for cooling a superconducting motor includes a combustor and fuel tank that contains a fuel. The system further includes a cooling system that provides the fuel to the superconducting motor or a cryocooler to cool the superconducting motor, resulting in at least partially vaporized fuel coming out of the superconducting motor or cryocooler. The cooling system also a cryocooler and a two-phase ejector that mixes the fuel from the tank and the at least partially vaporized fuel to produce a mixed fuel. The combustor receives the mixed fuel and generates electric power due its combustion. The power can be provided to the superconducting motor. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/146001 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 33/08 (20130101) Original (OR) Class B64D 41/00 (20130101) Dynamo-electric Machines H02K 55/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208870 | Klett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James W. Klett (Oak Ridge, Tennessee); Amelia M. Elliott (Oak Ridge, Tennessee) |
| ABSTRACT | A slurry composition for forming an article using additive manufacturing is provided. The slurry composition comprises a carrier having a viscosity of at least 0.001 cP at normal temperature and pressure. The carrier is adapted to be flowable through a nozzle. The slurry composition further comprises a material selected from the group of a metal-containing material, a ceramic-containing material, an inorganic carbon-containing material, a silica-containing material, and combinations thereof. |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/420010 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/10 (20220101) B22F 1/107 (20220101) B22F 10/16 (20210101) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2001/08 (20130101) B29K 2007/00 (20130101) B29K 2033/04 (20130101) B29K 2083/00 (20130101) B29K 2505/12 (20130101) B29K 2507/04 (20130101) B29K 2509/02 (20130101) B29K 2509/04 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) B33Y 70/10 (20200101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/48 (20130101) C04B 35/52 (20130101) Original (OR) Class C04B 35/522 (20130101) C04B 35/584 (20130101) Compositions of Macromolecular Compounds C08L 33/00 (20130101) C08L 71/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208884 | Stone et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Edward Stone (Evanston, Illinois); Francesca Arcudi (Evanston, Illinois); Luka Dordevic (Evanston, Illinois); Emily Allyn Weiss (Evanston, Illinois); Joseph T. Hupp (Northfield, Illinois); Samuel Isaac Stupp (Evanston, Illinois) |
| ABSTRACT | Methods for the photocatalytic reduction of alkynes to alkenes with high conversion yields and selectivities using a heterogeneous system that incorporates a cobalt-porphyrin into a metal-organic framework (MOF) are provided. The cobalt-porphyrin-based MOFs carry out the photocatalytic reductions in the presence of a visible-light activated photosensitizer molecule and a sacrificial electron donor. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/391358 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/183 (20130101) B01J 31/1691 (20130101) B01J 35/39 (20240101) B01J 2231/645 (20130101) B01J 2531/48 (20130101) B01J 2531/0216 (20130101) B01J 2531/821 (20130101) B01J 2531/845 (20130101) Acyclic or Carbocyclic Compounds C07C 5/09 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208885 | Arcudi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francesca Arcudi (Evanston, Illinois); Luka Dordevic (Evanston, Illinois); Emily A. Weiss (Evanston, Illinois); Samuel I. Stupp (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are compositions and methods for the selective photocatalytic reduction of an alkyne compound to an alkene compound (e.g., acetylene to ethylene). |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 18/556949 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/183 (20130101) B01J 35/39 (20240101) B01J 2231/645 (20130101) B01J 2531/845 (20130101) Acyclic or Carbocyclic Compounds C07C 5/09 (20130101) Original (OR) Class C07C 2531/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209224 | Fenn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David R. Fenn (Allison Park, Pennsylvania); Kurt G. Olson (Gibsonia, Pennsylvania); Reza M. Rock (Pittsburgh, Pennsylvania); Cynthia Kutchko (Pittsburgh, Pennsylvania); Susan F. Donaldson (Allison Park, Pennsylvania); Hao Sun (Allison Park, Pennsylvania) |
| ABSTRACT | Methods of printing a three-dimensional object using co-reactive components are disclosed. Thermosetting compositions for three-dimensional printing are also disclosed. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/423798 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/02 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/73 (20130101) C08G 18/325 (20130101) C08G 18/755 (20130101) C08G 18/792 (20130101) C08G 18/3225 (20130101) C08G 18/3228 (20130101) C08G 18/3234 (20130101) C08G 18/3821 (20130101) C08G 18/4854 (20130101) C08G 18/5024 (20130101) C08G 18/7893 (20130101) C08G 2150/50 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/03 (20130101) C09D 11/30 (20130101) C09D 11/38 (20130101) C09D 11/102 (20130101) Original (OR) Class C09D 175/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209253 | SMALLS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eden GeoPower, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | Eden GeoPower, Inc. (Somerville, Massachusetts) |
| INVENTOR(S) | Paris SMALLS (Boston, Massachusetts); Mehrdad MEHRVAND (Somerville, Massachusetts); Ammar ALALI (Cambridge, Massachusetts); Marybeth LUNDQUIST (The Woodlands, Texas) |
| ABSTRACT | The present disclosure describes electro-hydrofracturing (E-HF) using electrically conductive proppants and methods for hydraulic fracturing using electrically conductive proppants. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/509897 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/64 (20130101) C09K 8/70 (20130101) C09K 8/665 (20130101) C09K 8/805 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 36/001 (20130101) E21B 43/267 (20130101) E21B 49/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209472 | BANTA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| INVENTOR(S) | Scott BANTA (Fairfield, Connecticut); Farid KHOURY (Westlake, Ohio) |
| ABSTRACT | Rare earth elements (REEs) are recovered by dissolving an REE-containing source in one or more solvents. The resulting solution is contacted with block V repeats-in-toxin (RTX) domains of adenylate cyclase from Bordetella pertussis. These polypeptides are generally intrinsically disordered. However, upon binding an amount of the REEs and/or REE-containing compounds, the polypeptide folds to form a beta roll (BR) secondary structure. The polypeptides also adopt the BR structure at very low pH, e.g., below about 1.5, yet are still capable of effectively binding REEs. The metal-peptide constructs can then be isolated for recovery of REE products. Native and synthetic RTX/BR domains can be used to bind and recover REEs with higher binding capacity than lanmodulin and enhanced REE selectivity. For example, embodiments of the present disclosure can be used to extract REEs from electronic wastes such as NdFeB magnets, seaweed ashes, used during biomining and bioleaching operations, etc. |
| FILED | Wednesday, March 22, 2023 |
| APPL NO | 18/124822 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/18 (20130101) Original (OR) Class C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209476 | Kalsar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajib Kalsar (Richland, Washington); Vineet V. Joshi (Richland, Washington); Darrell R. Herling (Kennewick, Washington); Xiaolong Ma (Kowloon, China PRC); Jens T. Darsell (Richland, Washington); Benjamin J. Schuessler (Kennewick, Washington); Curt A. Lavender (Richland, Washington) |
| ABSTRACT | A metal matrix composite material and associated methods are disclosed. In one example, the metal matrix composite material includes ceramic particles distributed in multiple phases. In selected examples, the metal matrix composite material is formed by a process including applying a rotational force and an axial force to a feedstock at an interface and plasticizing a portion of the feedstock at the interface. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/484706 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/04 (20130101) Alloys C22C 1/10 (20130101) Original (OR) Class C22C 32/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209503 | Martinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Alex B. F. Martinson (Naperville, Illinois); Lei Cheng (Naperville, Illinois); Adam S. Hock (Chicago, Illinois); Jessica Catharine Jones (Aurora, Illinois); Ethan Phillip Kamphaus (Chicago, Illinois); Nannan Shan (Clarendon Hills, Illinois); Chunxin Luo (Chicago, Illinois) |
| ABSTRACT | A site-selective hydration strategy that enables site-selective atomic layer deposition (ALD). ALD is utilized to target specific locations on a crystalline material for deposition. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/088408 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/403 (20130101) C23C 16/4408 (20130101) C23C 16/45553 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209523 | Arges et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher George Arges (Baton Rouge, Louisiana); Gokul Venugopalan (Baton Rouge, Louisiana) |
| ABSTRACT | The present disclosure provides for electrochemical hydrogen pumps and methods of producing hydrogen. Embodiments provide for efficient and high yielding electrochemical hydrogen pumps that can operate at high temperatures here other pumps cannot operate effectively and an electrochemical hydrogen pump that can purify hydrogen from gas mixtures with large carbon monoxide compositions as other electrochemical hydrogen pumps technology cannot operate effectively with carbon monoxide in the gas mixture. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 18/557613 |
| CURRENT CPC | Separation B01D 53/326 (20130101) B01D 2257/102 (20130101) B01D 2257/108 (20130101) B01D 2257/502 (20130101) B01D 2257/504 (20130101) B01D 2257/7025 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) C25B 9/23 (20210101) Original (OR) Class C25B 11/032 (20210101) C25B 11/052 (20210101) C25B 11/054 (20210101) C25B 11/065 (20210101) C25B 11/081 (20210101) C25B 13/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209810 | Hoye et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Earl Hoye (Columbus, Indiana); Jeffrey D. Jones (Columbus, Indiana); Daniel J. Mohr (Columbus, Indiana); David M. Barnes (Columbus, Indiana); Timothy Shipp (Seynour, Indiana) |
| ABSTRACT | A cylinder head includes novel designs for undercuts, contours of the outer enclosure, coolant jackets, and other cavities within an outer enclosure of the cylinder head. The cylinder head design enables the reduction of weight of the head while maintaining structural integrity of the head, and improves control of temperatures in intake side and exhaust side zones of the heads to improve operational efficiency of the engine. A method is provided for additive manufacturing of the cylinder head including the disclosed designs. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/596931 |
| CURRENT CPC | Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 1/38 (20130101) Original (OR) Class F02F 1/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209825 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Chen (West Lafayette, Indiana); Haiyan H. Zhang (West Lafayette, Indiana); Charles Greg Jensen (West Lafayette, Indiana) |
| ABSTRACT | A hydrokinetic turbine system for harvesting energy from riverine and tidal sources, including a first floating dock, a marine hydrokinetic turbine mounted on the first floating dock, and a second floating dock. The system further includes a winch assembly mounted on the second floating dock and operationally connected to the first floating dock and a linkage assembly operationally connected to the first floating dock and to the second floating dock. The linkage assembly may be actuated to pull the first floating dock into contact with the second floating dock. The linkage assembly may be actuated to distance the first floating dock from the second floating dock, and the winch assembly may be energized to orient the first floating dock into a position wherein the marine hydrokinetic turbine is above the first floating dock and wherein the winch assembly may be energized to orient the first floating dock into a position wherein the marine hydrokinetic turbine is below the first floating dock. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584073 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 1/28 (20130101) B63B 21/16 (20130101) B63B 35/44 (20130101) B63B 2035/4466 (20130101) Machines or Engines for Liquids F03B 3/145 (20130101) Original (OR) Class Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2220/32 (20130101) F05B 2240/93 (20130101) F05B 2240/95 (20130101) F05B 2260/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210130 | Roehling et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Roehling (Livermore, California); Michael Bagge-Hansen (San Leandro, California); Hannah V. Eshelman (Dublin, California); Mariana Desireé Reale Batista (Livermore, California); Tien T. Roehling (Tracy, California); Alyssa L. Troksa (Livermore, California) |
| ABSTRACT | An apparatus for cooling a surface includes a composite that includes a porous infrared (IR) transparent material having at least one substance that is transparent to infrared radiation having a wavelength in a range of 8 to 13 μm. In addition, the composite includes a support frame having an opening for exposing a sky-facing surface of the porous IR transparent material and an encapsulant. The encapsulant is positioned on the sky-facing surface of the porous IR transparent material. The composite is configured to be optically reflective to sunlight and is thermally insulating for reducing heating of a surface from surrounding air. |
| FILED | Friday, March 08, 2024 |
| APPL NO | 18/600120 |
| CURRENT CPC | Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/003 (20130101) Original (OR) Class F28F 21/04 (20130101) F28F 2255/06 (20130101) F28F 2270/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210133 | Carlson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Vacuum Process Engineering, Inc. (Sacramento, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew David Carlson (Highlands Ranch, Colorado); Blake Lance (Albuquerque, New Mexico); Parker Riley Lyons (Herriman, Utah); Dereje Amogne (Rocklin, California); Aaron Wildberger (El Dorado Hills, California) |
| ABSTRACT | A header for a heat exchanger and method for cleaning a heat exchanger in a loop without disconnecting loop components is provided. The header is in flow communication with the heat exchanger for distributing fluid through a plurality of adjacent channels. The header is connected between a main heat exchanger inlet nozzle and a channel flow distributor. A filter element is disposed within the header between the nozzle and channel flow distributor. Under normal operation, the filter element removes particulates and fouling material from the main flow stream before it enters the heat exchanger channels. During the cleaning process, fluid is injected on or through the filter element to remove particulates and fouling material through at least one outlet port. The header arrangement allows the filter element to be ‘cleaned in place’ without draining the system and disconnecting the heat exchanger or other components from the flow loop. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/509985 |
| CURRENT CPC | Separation B01D 29/01 (20130101) B01D 29/66 (20130101) B01D 2201/086 (20130101) B01D 2201/184 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 9/0265 (20130101) F28F 19/01 (20130101) Original (OR) Class F28F 2250/00 (20130101) F28F 2265/02 (20130101) F28F 2265/22 (20130101) Cleaning of Internal or External Surfaces of Heat-exchange or Heat-transfer Conduits, e.g Water Tubes or Boilers F28G 9/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210356 | Zang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoqin Zang (Richland, Washington); Zhiqun Deng (Richland, Washington); Wei Wang (West Richland, Washington); Litao Yan (Richland, Washington); Zimin Nie (Edmonds, Washington) |
| ABSTRACT | This document describes techniques and systems for in operando, non-invasive monitoring of byproducts that commonly arise within redox flow batteries. The described techniques and systems allow for accurate, inexpensive, portable, and real-time methods to measure evolution of gas bubbles and precipitates within the electrolyte solutions of redox flow batteries. System operators can monitor and maintain the amount of byproducts within the electrolyte solution by measuring an acoustic attenuation coefficient of the electrolyte solution and changes in the speed at which ultrasonic echoes propagate through the solution. The acoustic attenuation coefficient is measured using an ultrasonic transducer attached to a probing cell, which is connected to an electrolyte flow of a redox flow battery. The acoustic attenuation coefficient provides an accurate, real-time identification of byproducts that is generally insensitive to varying operational temperatures of the electrolyte solution. The probing cell also allows examination of the sound speed as it detects echoes of the transmitted frequencies. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541396 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/024 (20130101) G01N 29/032 (20130101) Original (OR) Class G01N 29/2475 (20130101) G01N 2291/02416 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) H01M 8/04313 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210491 | Piesciorovsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emilio Charles Piesciorovsky (Oak Ridge, Tennessee); Raymond Charles Borges Hink (Knoxville, Tennessee); Aaron William Werth (Knoxville, Tennessee); Gary Hahn (Loudon, Tennessee); Maximiliano Flavio Ferrari Maglia (Knoxville, Tennessee); Marissa Enid Morales Rodriguez (West Palm Beach, Florida) |
| ABSTRACT | A phase to ground fault apparent (PGFA) admittance system and method with phase/ground boundaries for detecting electrical power line faults. The PGFA admittance method with phase/ground boundaries is based on measuring the A, B and C phase admittance magnitudes for faulted and non-faulted phases, resulting in greater than zero and near zero, respectively, and using the phase/ground boundaries to distinguish between the LL and LLG electrical faults. The PGFA admittance method with phase/ground boundaries is based on a pre-setting of values by using the zero, positive and negative sequences of power line sections, to determine phase and ground boundaries. The PGFA admittance algorithm with phase/ground boundaries was built with MATLAB/Simulink software and tested and evaluated with a confusion matrix. The measured and predicted values matched in more than 90% of the tests, and the PGFA admittance method presented an accuracy of 94.3% and a precision of 100%. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/375147 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/52 (20200101) Original (OR) Class G01R 31/086 (20130101) G01R 31/088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240211646 | HUN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Diana HUN (Lenoir City, Tennessee); Peter Lee-Shein WANG (Oak Ridge, Tennessee); Nolan W. HAYES (Jefferson City, Tennessee); Bryan Maldonado PUENTE (Knoxville, Tennessee); Philip R. BOUDREAUX (Knoxville, Tennessee); Stephen M. KILLOUGH (Knoxville, Tennessee) |
| ABSTRACT | A real-time evaluator decreases the cost of building envelope construction and retrofits by reducing the installation time for overclad panels and enhancing performance of the panels through higher installation quality. The real-time evaluator includes a machine vision subsystem to measure real-time locations of the panels as their being installed, a digital twin manager device to manage a current panel position digital twin based on the real-time measurements and make comparisons to a target panel position digital twin. The comparisons can be used to provide installation guidance to panel installers that can improve both the speed and accuracy of installation. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/509721 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/13 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240211791 | Chong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederic T. Chong (Chicago, Illinois); Jason Chadwick (Chicago, Illinois) |
| ABSTRACT | A quantum computing system for optimizing instructions of a quantum circuit is configured to: select reference points in a parameter space of a family of gates that are executable by the quantum processor; identify edges in the parameter space connecting two reference points; compute a pulse vector for each reference point of the plurality of reference points; optimize the pulse vector for each reference point of the plurality of reference points based on the first pulse vector of each neighboring reference point connected to that reference point by an edge; receive a target operation from the quantum circuit for optimization; compute a second pulse vector for the target operation based on interpolating between a subset of reference points of the plurality of reference points; and executed the target operation on a quantum processor using the pulse vector for the target operation. |
| FILED | Thursday, March 23, 2023 |
| APPL NO | 18/188731 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30036 (20130101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) G06N 10/60 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212340 | Roberts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randy S. Roberts (Livermore, California); John Goforth (Carlsbad, California) |
| ABSTRACT | A system is provided for identifying and quantizing a change in a scene having objects based on comparison of features representing a target object derived from a first image and a second image that includes the target object. The system segments, based on a scene model of the scene, a second image that includes the target object to identify a second area representing the target object within the second image. The system extracts, from the second image, second features for the target object based on the second area. The system determines determine a second effectiveness of the second features indicating effectiveness of the second features in representing the target object. The system detects a change based on a difference between first features and the second features factoring in a first effectiveness and the second effectiveness. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/460057 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/214 (20230101) G06F 18/217 (20230101) Image Data Processing or Generation, in General G06T 7/174 (20170101) Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 10/60 (20220101) G06V 10/462 (20220101) G06V 10/774 (20220101) G06V 10/776 (20220101) G06V 20/13 (20220101) Original (OR) Class G06V 2201/07 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240212870 — EFFECTIVE COATING MORPHOLOGY TO PROTECT ZR ALLOY CLADDING FROM OXIDATION AND HYDRIDING
| US 20240212870 | LAHODA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Edward J. LAHODA (Edgewood, Pennsylvania); Elwyn ROBERTS (Lugoff, South Carolina); Benjamin R. MAIER (Pittsburgh, Pennsylvania); Allan Wayne JAWORSKI, JR. (Canonsburg, Pennsylvania); Arash PARSI (Sarver, Pennsylvania); Guoqiang WANG (Murrysville, Pennsylvania); William A. BYERS (Murrysville, Pennsylvania); Jorie WALTERS (Columbia, South Carolina); Chona P. VALLENCOUR (Indian Land, South Carolina); John Leo LYONS (Pittsburgh, Pennsylvania); Luke CZERNIAK (North Huntingdon, Pennsylvania); Roy J. MATWAY (Pittsburgh, Pennsylvania); Gregory E. ROBERTS (Heron, Montana); Kathryn E. METZGER (Columbia, South Carolina); Jonathan WRIGHT (Västerås, Sweden); Luke C. OLSON (Columbia, South Carolina); Denise ADORNO-LOPES (Västerås, Sweden) |
| ABSTRACT | A coating for protecting a Zirconium alloy based layer of a nuclear fuel rod cladding is provided. The coating comprises a primary layer. A microstructure of the primary layer is comprised of a number of grains and is randomized. The primary layer is configured with a density of about 94.5% or greater. A cladding for a nuclear fuel rod and a method for producing a cladding for a nuclear fuel rod are also provided. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/069864 |
| CURRENT CPC | Nuclear Reactors G21C 3/07 (20130101) Original (OR) Class G21C 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212994 | Stoltz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter H. Stoltz (Denver, Colorado); Eric T. Meier (Seattle, Washington); Uri Shumlak (Seattle, Washington); Brian A. Nelson (Edmonds, Washington) |
| ABSTRACT | Methods and systems are provided for increasing energy output from Z-pinch and other plasma confinement systems. In one example, a system may include memory storing instructions that, if executed by one or more processors, cause the system to adjust one or more parameters to generate a magnetic field which is sufficiently strong to axially compress a fuel gas to induce thermonuclear fusion and increase a fusion energy gain factor greater than a fusion energy gain factor limit attainable by the thermonuclear fusion. In certain examples, adjusting the one or more parameters may include adjusting a duty cycle of a discharge current applied to the fuel gas based, at least in part, on an amount of thermal collisions between fusion byproducts and the fuel gas. In certain examples, by adjusting the duty cycle, the magnetic field may be adjusted to induce or increase the thermal collisions. |
| FILED | Wednesday, November 15, 2023 |
| APPL NO | 18/510456 |
| CURRENT CPC | Fusion Reactors G21B 1/05 (20130101) G21B 1/21 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/3266 (20130101) Original (OR) Class H01J 37/32064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213437 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongli Zhu (Arlington, Massachusetts); Ying Wang (Boston, Massachusetts) |
| ABSTRACT | A screen-printable electrode battery ink is described comprising a slurry of an active ingredient, conductive additive, a binder, and a solvent, the slurry having a solids content from about 40% by weight to about 70% by weight that is uniformly distributed in the solvent, wherein the ink has a thixotropic recovery rate from about 30 seconds to about 90 seconds, and wherein the binder has untwisted molecular chains. Methods for making the screen-printable electrode battery ink are also described. The screen-printable electrode battery inks can be used to screen print electrodes, for use in fast-charging battery. Fast-charging batteries can be incorporated into electronic devices, such as electric vehicles. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545285 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0414 (20130101) Original (OR) Class H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 2220/20 (20130101) H01M 2220/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213438 | CAIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Jeffrey David CAIN (Royal Oak, Michigan); Thomas E. MOYLAN (Dearborn Heights, Michigan); Sayed Youssef Sayed NAGY (Troy, Michigan); Nicholas Paul William PIECZONKA (Windsor, Canada); Yuntao GU (Farmington Hills, Michigan) |
| ABSTRACT | A method for forming an electroactive material includes sourcing a current or voltage to an electrochemical reactor that includes a cation source, an electrolyte mixture, and an electroactive material precursor in contact with one another, where the current or voltage serves to ionize and form cations at the cation source that react with the electroactive material precursor in the electrolyte mixture to form the electroactive material. The method may include one or more filtering steps, one or more rinsing steps, or a combination of one or more filtering steps and one or more rinsing steps to collect the electroactive material from the electrolyte. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/087421 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0459 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213521 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Yuepeng ZHANG (Naperville, Illinois); Sanja TEPAVCEVIC (Chicago, Illinois); Devon J. POWERS (Lemont, Illinois); Peter ZAPOL (Hinsdale, Illinois); John N. HRYN (Hawthorn Woods, Illinois); Gregory K. KRUMDICK (Homer Glen, Illinois); Ozgenur KAHVECIOGLU (Naperville, Illinois); Krzystof Z. PUPEK (Plainfield, Illinois); Michael John COUNIHAN (Downers Grove, Illinois) |
| ABSTRACT | A cathode for a multilayer solid-state electrochemical cell is described herein. The cathode comprises nanofibers of a cathode active material; particles of the cathode active material; and nanofibers of a cubic phase lithium lanthanum zirconium oxide (c-LLZO); all of which are dispersed in a polymeric matrix. Electrochemical cells comprising a solid-state electrolyte and the cathodes comprising the nanofibers of c-LLZO are also described herein. |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/420356 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/056 (20130101) Original (OR) Class H01M 2004/021 (20130101) H01M 2004/028 (20130101) H01M 2300/0077 (20130101) H01M 2300/0082 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213773 | Elio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Joseph Elio (Mesa, Arizona); Ryan Milcarek (Gilbert, Arizona); Miguel Peinado-Guerrero (Phoenix, Arizona); Jesus Villalobos (Mesa, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Joseph Elio (Mesa, Arizona); Ryan Milcarek (Gilbert, Arizona); Miguel Peinado-Guerrero (Phoenix, Arizona); Jesus Villalobos (Mesa, Arizona) |
| ABSTRACT | A system applies optimal peak-clipping (PC) and load-shifting (LS) control strategies of a Li-ion BESS at a large industrial facility with and without enrollment in the electrical utility company's event-based DR program. The optimally sized BESSs and discounted payback periods are determined for both control strategies with and without event-based DR enrollment. Additional optimization can be performed to reduce an environmental impact of using the BESS. Comparisons between the PC and LS control strategies' operations show that for the same sized Li-ion BESS with DR enrollment, the LS control strategy achieves more revenue in DR events and by leveraging the energy-price arbitrage. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545807 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/003 (20200101) Original (OR) Class H02J 3/32 (20130101) H02J 2203/10 (20200101) H02J 2203/20 (20200101) H02J 2310/60 (20200101) H02J 2310/64 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213778 | Montaño Martinez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Karen Montaño Martinez (Tempe, Arizona); Vijay Vittal (Scottsdale, Arizona); Shanshan Ma (Las Vegas, Nevada) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Karen Montaño Martinez (Tempe, Arizona); Vijay Vittal (Scottsdale, Arizona); Shanshan Ma (Las Vegas, Nevada) |
| ABSTRACT | A system for accurate secondary network topology geographic information system (GIS) coordinates correction provides a more accurate feeder topology for utilities to estimate and operate distribution systems by assigning the load and distributed energy resources (DER) nodes to their corresponding customer location. To simplify the complexity of the system, only two commonly available inputs are being used as input data: municipal parcel GIS delimitation data, and utility secondary feeder topology database. The system includes a three-stage framework: the first stage reads and processes the raw input data; the second stage works automatically with no human intervention to assign the load and DER nodes to their associated location; the third stage provides the load and DER coordinates and physical address. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/393040 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/144 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213974 | Sampayan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Stephen E. Sampayan (Manteca, California); Kristin C. Sampayan (Manteca, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen E. Sampayan (Manteca, California); Kristin C. Sampayan (Manteca, California) |
| ABSTRACT | Devices, methods and techniques related to ultrafast latching switches are disclosed. In one example aspect, a device includes a photoconductive switch and a non-mechanical latching switch configured to maintain a state after the state is activated. The non-mechanical latching switch is coupled to the photoconductive switch. The non-mechanical latching switch is configured to be triggered to switch to an opposite state upon an activation of the photoconductive switch. |
| FILED | Wednesday, December 27, 2023 |
| APPL NO | 18/398068 |
| CURRENT CPC | Pulse Technique H03K 17/94 (20130101) H03K 17/0403 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240206996 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Agrim Gupta (La Jolla, California); Cedric Girerd (La Jolla, California); Manideep Dunna (La Jolla, California); Tania Morimoto (La Jolla, California); Dinesh Bharadia (La Jolla, California); Raghav Subbaraman (La Jolla, California); Qiming Zhang (La Jolla, California) |
| ABSTRACT | A wireless force sensor includes a flexible structure supported opposing a rigid structure with a gap between the flexible structure and the rigid structure. Contact traces on opposing surfaces of the flexible structure and the rigid structure form transmission lines. The contract traces are aligned to contact when a force is applied the flexible structure to cause contact between the traces on the opposing surfaces. Radio-frequency switches modulate a reflected signal from the transmission lines. An antenna receives an interrogation signal transmits the reflected signal. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/554726 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/30 (20160201) Original (OR) Class A61B 2090/064 (20160201) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/106 (20130101) G01L 5/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207454 | Zupanc et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gunther Zupanc (Auburndale, Massachusetts); David Lehotzky (Boston, Massachusetts) |
| ABSTRACT | Disclosed are a system and an in vivo assay for the physiological evaluation of water-soluble general anesthetics. The assay is based on the effects of anesthetics on the frequency of the pacemaker nucleus, an endogenous neural oscillator in the brainstem, of the weakly electric fish Apteronotus leptorhynchus. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538612 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207486 | MA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Minglin MA (Ithaca, New York); Longhai WANG (Ithaca, New York); Alexander ERNST (Ithaca, New York) |
| ABSTRACT | Disclosure herein are an implantable cell containing device, its subcomponent scaffold, methods of making the same and their methods of use. The implantable cell containing device includes a scaffold and a cell-containing hydrogel encapsulating the scaffold. The scaffold has a tracheal-like internal system of continuous air-filled, hydrophobic micro-channels that traverse the scaffold's dimensions and a hydrophilic external surface. The implantable cell containing device, when implanted in a subject, can be used for delivering a therapeutic agent to a subject in need thereof for the treatment of various conditions and diseases. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 18/555184 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/34 (20130101) A61L 27/52 (20130101) A61L 27/3804 (20130101) Original (OR) Class A61L 27/3834 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207491 | Boire et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy C. Boire (Nashville, Tennessee); Hak-Joon Sung (Nashville, Tennessee); Colleen Brophy (Nashville, Tennessee) |
| ABSTRACT | The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photo crosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/380135 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/07 (20130101) A61F 2/90 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) Original (OR) Class A61L 31/16 (20130101) A61L 31/041 (20130101) A61L 2400/16 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207637 | Green |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hadiyah-Nicole Green (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hadiyah-Nicole Green (Atlanta, Georgia) |
| ABSTRACT | Methods, structures, devices and systems are disclosed for implementing a photothermal therapy using nanostructures. In one aspect, a device to produce a photothermal effect includes a particle having a molecular layer functionalized onto the external surface of the particle and structured to attach to one or more targeting molecules capable of binding to a receptor site of a cell, in which the particle is configured to absorb light energy at a particular wavelength to produce a plasmon resonance effect that causes the particle to emit heat energy. In some implementations, the device is deployed in an organism having a tumor that includes a plurality of the cell and binds to the receptor site of the tumor by the targeting molecules, in which the light energy is emitted at a region of the organism that contains the tumor and the heat energy causes cellular death of the tumor cell. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594053 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 2005/063 (20130101) A61N 2005/0644 (20130101) A61N 2005/0659 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 3/108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208044 | Saintyves et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); Illinois Institute of Technology (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baudouin Saintyves (Chicago, Illinois); Heinrich M. Jaeger (Chicago, Illinois); Matthew J. Spenko (Chicago, Illinois) |
| ABSTRACT | A robotic system includes a first robotic unit, where the first robotic unit includes a wheel and an actuator that is mounted to the wheel. The actuator is configured to rotate an active rotor that is mounted within the wheel. The first robotic unit also includes an actuated magnet that is mounted to the active rotor such that the actuator controls rotation of the actuated magnet within the wheel. The first robotic unit also includes a free magnet mounted to a passive rotor that rotates within the wheel. Movement of the actuated magnet by the actuator causes rotation of the wheel, and wherein the free magnet is configured to attach to a second actuated magnet of a second robotic unit to facilitate movement of the first robotic unit, and allow for continuous, material-like, deformation in a multi-units aggregate. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392132 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/065 (20130101) Original (OR) Class B25J 9/126 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208137 | HUANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong HUANG (Gainesville, Florida); Marc SOLE GRAS (Gainesville, Florida); Bing REN (Gainesville, Florida) |
| ABSTRACT | A polymer three-dimensional (3D) printing methodology is disclosed for freeform fabrication of polymeric structures under ambient conditions without the use of printed support structures, without use of a support bath, and the like. The build material can be dissolved in a suitable solvent for 3D printing. The polymer solution can be printed (e.g., continuously printed using a moving dispensing nozzle) in air without the use of supports (e.g., without the use of a support bath, a concurrently printed support posts, or the like) while a nebulized coagulation agent is dispersed alongside the printed polymer solution to at least partially coagulate the polymer solution and form an intermediate article. The self-supporting intermediate article may then be immersed in a post-printing coagulation solution to remove some or all of the remaining solvent, causing the build material to fully solidify to form a finished article from the intermediate article. |
| FILED | Thursday, August 10, 2023 |
| APPL NO | 18/232569 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/30 (20170801) B29C 64/112 (20170801) Original (OR) Class B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240208815 | Groves et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| INVENTOR(S) | John T. Groves (Princeton, New Jersey); Roy Xiao (Princeton, New Jersey) |
| ABSTRACT | Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2− to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405407 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/18 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/26 (20130101) B01J 31/183 (20130101) B01J 31/1815 (20130101) B01J 31/2295 (20130101) B01J 2531/025 (20130101) B01J 2531/842 (20130101) Non-metallic Elements; Compounds Thereof; C01B 11/024 (20130101) Original (OR) Class Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/76 (20130101) C02F 2103/023 (20130101) C02F 2303/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor D21C 9/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209034 | SELLERS et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Drew SELLERS (Seattle, Washington); Ian CARDLE (Seattle, Washington); Suzie Hwang PUN (Seattle, Washington) |
| ABSTRACT | Embodiments of the claimed invention are directed to synthetic peptides comprising an amino acid sequence of X1X2VX3NLRGDLQVLX4QKVCX5T (SEQ ID NO:18), wherein at least one of X1 and X2 is a cysteine, and wherein one or more of X3, X4, and X5 is a non-natural amino acid. Also described are methods of using the claimed embodiments for inhibiting growth of a cancer cell overexpressing integrin αvβ6. Additionally, also described are methods of using the claimed embodiments for detecting a cancer cell overexpressing integrin αvβ6. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/554737 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/32122 (20130101) C12N 2770/32133 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209274 | Berman et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of North Texas (Denton, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Diana Berman (Denton, Texas); Asghar Shirani (Denton, Texas) |
| ABSTRACT | The present disclosure provide for coatings, coated structures, methods of coating, methods of coating a structure, and the like. In an aspect, the coating is a tribocatalytically-active coating, where the tribocatalytically-active coating interacts with the hydrocarbon environment forming a protective carbon-based tribofilm on the surface of the coating, which can be actively formed (reformed) during use of the coated structure within the hydrocarbon environment. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545198 |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 103/06 (20130101) Original (OR) Class C10M 105/04 (20130101) C10M 105/12 (20130101) C10M 111/02 (20130101) C10M 177/00 (20130101) C10M 2201/0603 (20130101) C10M 2203/022 (20130101) C10M 2207/0215 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2050/023 (20200501) C10N 2070/00 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 9/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209447 | Cong et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Le Cong (Stanford, California); Nicholas W. Hughes (Stanford, California) |
| ABSTRACT | The present disclosure provides systems, methods, nucleic acids, and kits for barcoding and tracking cells based on CRISPR editing technologies. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/287619 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) C12Q 1/6813 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/922 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/50 (20190201) G16B 25/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240209472 | BANTA et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| INVENTOR(S) | Scott BANTA (Fairfield, Connecticut); Farid KHOURY (Westlake, Ohio) |
| ABSTRACT | Rare earth elements (REEs) are recovered by dissolving an REE-containing source in one or more solvents. The resulting solution is contacted with block V repeats-in-toxin (RTX) domains of adenylate cyclase from Bordetella pertussis. These polypeptides are generally intrinsically disordered. However, upon binding an amount of the REEs and/or REE-containing compounds, the polypeptide folds to form a beta roll (BR) secondary structure. The polypeptides also adopt the BR structure at very low pH, e.g., below about 1.5, yet are still capable of effectively binding REEs. The metal-peptide constructs can then be isolated for recovery of REE products. Native and synthetic RTX/BR domains can be used to bind and recover REEs with higher binding capacity than lanmodulin and enhanced REE selectivity. For example, embodiments of the present disclosure can be used to extract REEs from electronic wastes such as NdFeB magnets, seaweed ashes, used during biomining and bioleaching operations, etc. |
| FILED | Wednesday, March 22, 2023 |
| APPL NO | 18/124822 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/18 (20130101) Original (OR) Class C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210158 | Liang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rongguang Liang (Tucson, Arizona) |
| ABSTRACT | Methods, devices and systems for measuring surface roughness and surface shape of an object are described. An example interferometric system includes a collimator and a first and a second light sources with different spectral ranges and different coherence lengths. The system selectively allows light from one of the light sources to reach the collimator, and also includes a beamsplitter, and a Mirau type microscope having an objective lens, a plate with a central reflective spot and a beamsplitter plate to produce a reference beam and a test beam. An imaging lens receives the test and reference beams that form a plurality of interferograms. A neural network receives two of the interferograms for measuring the surface shape and another two interferograms for measuring the surface roughness of the object. The interferometric systems have a compact form, making them suitable for on-machine measurements and other applications. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 18/555423 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/04 (20130101) G01B 9/02007 (20130101) G01B 9/02087 (20130101) Original (OR) Class G01B 11/30 (20130101) G01B 11/2441 (20130101) G01B 2290/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210314 | Martin et al. |
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| FUNDED BY |
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| APPLICANT(S) | MONSTR Sense Technologies, LLC (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric W. Martin (Ann Arbor, Michigan); Torben L. Purz (Nordhorn, Germany); Steven T. Cundiff (Ann Arbor, Michigan) |
| ABSTRACT | An electronic circuit includes signal processing electronics. The electronic circuit receives an electrical signal generated by a photodetector based on a light beam from a location on a material including a signal of interest and one or more modulation frequencies. The electronic circuit discriminates a portion of the electrical signal proportional to a characteristic of the signal of interest from other components of the electrical signal using a low pass filter with a transfer function including a notch at a notch frequency corresponding to one of the modulation frequencies. The electronic circuit determines a value for the characteristic of the signal of interest from the discriminated portion of the electrical signal. The signal processing electronics further outputs the value of the characteristic of the signal of interest. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/554654 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3563 (20130101) Original (OR) Class G01N 21/9501 (20130101) G01N 2021/3568 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210384 | SCHNEIDER et al. |
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| FUNDED BY |
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| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia); EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca S. SCHNEIDER (Atlanta, Georgia); Andres J. GARCIA (Atlanta, Georgia); Wilbur A. LAM (Atlanta, Georgia); Evelyn Kendall WILLIAMS (Atlanta, Georgia); Karen E. MARTIN (Atlanta, Georgia) |
| ABSTRACT | A high-throughput, scalable, low-cost, on-chip microfluidic potency assay for nondifferentiated cells such as human mesenchymal stromal cells (hMSCs) with improved functional predictive power and recapitulation of in vivo secretory responses compared to traditional approaches. By comparison of hMSC secretory responses to functional hMSC-medicated immune cell suppression, on-chip microfluidic potency markers are identified with improved functional predictive power compared to traditional planar methods. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 18/558026 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) Original (OR) Class G01N 2333/57 (20130101) G01N 2333/96494 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210671 | Lew et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Lew (St. Louis, Missouri); Oumeng Zhang (St. Louis, Missouri) |
| ABSTRACT | An imaging system uses a multi-view reflector (MVR) to simultaneously measure the three-dimensional (3D) position and orientation of a light emitter. The MVR is positioned at a back focal plane (BFP) of a light collecting optical system, and uses pyramid reflectors and/or conical reflectors to reflect light in at least two regions of the BFP to at least two detection channels of a detector. The at least two detection channels produce images that are used to determine the 3D position and orientation of a light emitter. The system may be used, for example, to image the structure of molecules or organelles in a cell, track the movement of molecules in a cell, or to study the interaction of molecules within a cell. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 18/254448 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/18 (20130101) G02B 21/361 (20130101) Original (OR) Class G02B 27/14 (20130101) G02B 27/283 (20130101) G02B 27/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210786 | Gausmann et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| INVENTOR(S) | Stefan Gausmann (Orlando, Florida); Axel Schulzgen (Orlando, Florida) |
| ABSTRACT | The discovery of a clear correlation between the Anderson localization length and the dispersion properties of highly localized TALOF modes allowed us to demonstrate that the zero dispersion wavelength can be tuned over more than 300 nm within the same fiber by selected excitation of specific modes. This enabled apparatus and methods for generating tunable, multi-octave-spanning supercontinuum (SC) spectra in a bandwidth from 460 nm to 1750 nm. Associated applications are also presented. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 18/556963 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/3528 (20210101) Original (OR) Class G02F 1/3551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210878 | VARSHNEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amitabh VARSHNEY (Potomac, Maryland); Susmija JABBIREDDY (Berwyn Heights, Maryland); Mario DAGENAIS (Chevy Chase, Maryland); Martin C. PECKERAR (Silver Spring, Maryland); Yang ZHANG (Silver Spring, Maryland) |
| ABSTRACT | Sparse nanophotonic arrays (NPAs) and holographic displays comprise a rectangular footprint including an active pixel area, wherein the active pixel area includes a plurality of light-emitting elements arranged in a starburst shape, and wherein a total number of the plurality of light-emitting elements in the active pixel area is equal to a predetermined fraction of a total resolution of a dense nanophotonic array having the rectangular footprint. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/542174 |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/265 (20130101) Original (OR) Class G03H 2001/2655 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210913 | Nemani et al. |
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| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa); Percev LLC (Davenport, Iowa) |
| ASSIGNEE(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa); Percev LLC (Davenport, Iowa) |
| INVENTOR(S) | Venkat Pavan Nemani (Ames, Iowa); Chao Hu (Sudbury, Massachusetts); Hao Lu (Qingdao, China PRC); Andrew T. Zimmerman (Bettendorf, Iowa) |
| ABSTRACT | A method for predicting remaining useful life for industrial equipment and associated sensor modules are provided. The method includes monitoring machine sensor data for the industrial equipment in an industrial environment using at least one sensor and applying a two-tier model implemented by a computing device by executing a set of instructions from a non-transitory machine readable memory using a processor of the computing device. The two-tier model receives as input sensor data comprising the machine sensor data and applies physics of failure of the industrial equipment to determine a prediction for remaining useful life for the industrial equipment, uncertainty in the prediction for the remaining useful life for the industrial equipment, and an explanation to the prediction for the remaining useful life for the industrial equipment. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/540455 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4065 (20130101) Original (OR) Class G05B 2219/50185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210956 | Barawkar et al. |
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| FUNDED BY |
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| APPLICANT(S) | Shraddha Barawkar (Cincinnati, Ohio); Manish Kumar (Cincinnati, Ohio); Kelly Cohen (Mason, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shraddha Barawkar (Cincinnati, Ohio); Manish Kumar (Cincinnati, Ohio); Kelly Cohen (Mason, Ohio) |
| ABSTRACT | Systems, methods, and computer program products for controlling a drone using a tether. A drone is coupled to a distal end of the tether, and a force sensor measures one or more force parameters exerted on the drone by the tether. The force parameters are in turn used to generate control parameters, and the control parameters provided to a flight controller. The flight controller generates one or more propulsion parameters based on the control parameters, and provides the propulsion parameters to respective propulsion units of the drone. The drone can thereby be controlled by manipulating a proximate end of the tether, which changes the force parameters measured by the force sensor. |
| FILED | Monday, January 29, 2024 |
| APPL NO | 18/425574 |
| CURRENT CPC | Unmanned aerial vehicles [UAV]; equipment therefor B64U 10/60 (20230101) B64U 2201/202 (20230101) Systems for Controlling or Regulating Non-electric Variables G05D 1/49 (20240101) Original (OR) Class G05D 2109/20 (20240101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240211618 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adrian Tang (New York, New York); Salvatore Stolfo (New York, New York); Lakshminarasimhan Sethumadhavan (New York, New York) |
| ABSTRACT | Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method that includes determining whether an operation to access a memory location containing executable code comprises a general-purpose memory access operation, and changing content of the memory location in response to a determination that the operation to access the memory location containing the executable code comprises the general-purpose memory access operation to the memory location. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/386504 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) G06F 12/1009 (20130101) G06F 12/1475 (20130101) G06F 21/52 (20130101) G06F 21/604 (20130101) G06F 21/6218 (20130101) Original (OR) Class G06F 2009/45583 (20130101) G06F 2009/45595 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240211791 | Chong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederic T. Chong (Chicago, Illinois); Jason Chadwick (Chicago, Illinois) |
| ABSTRACT | A quantum computing system for optimizing instructions of a quantum circuit is configured to: select reference points in a parameter space of a family of gates that are executable by the quantum processor; identify edges in the parameter space connecting two reference points; compute a pulse vector for each reference point of the plurality of reference points; optimize the pulse vector for each reference point of the plurality of reference points based on the first pulse vector of each neighboring reference point connected to that reference point by an edge; receive a target operation from the quantum circuit for optimization; compute a second pulse vector for the target operation based on interpolating between a subset of reference points of the plurality of reference points; and executed the target operation on a quantum processor using the pulse vector for the target operation. |
| FILED | Thursday, March 23, 2023 |
| APPL NO | 18/188731 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30036 (20130101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) G06N 10/60 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212080 | Dorodchi et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina Charlotte (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohsen Dorodchi (Charlotte, North Carolina); Elise Demeter (Huntersville, North Carolina) |
| ABSTRACT | A model trained with student-specific academic data, student-specific financial data, institutional policy data, and student-specific outcomes is provided. Subject student-related academic data and subject student-related financial data are applied to the model to generate advisor-facing metrics and/or student-facing metrics relating to student progress, such as a financial estimate pertaining to completion of a degree, a predicted student success indicator, and/or the like. A student-facing user interface and advisor-facing user interface facilitates configuration and collaboration of a student-specific academic plan, and intervention by advisor-users. The model is routinely updated and trained online, and an administrator-facing interface enables configuration per institution. Users are notified of alerts or changes in predicted outcomes. The model may include a large language model to facilitate natural language interaction and/or feedback. The system addresses security, privacy, system integration, and customization needs of higher education institutional systems. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541434 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/2053 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212341 | Fathi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Pointivo, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Habib Fathi (Atlanta, Georgia); Jacob B. Garland (Peachtree Corners, Georgia); William Wilkins (Suwanee, Georgia); Daniel Ciprari (Atlanta, Georgia) |
| ABSTRACT | Various examples are provided for data acquisition, processing, and output generation for use in analysis of a physical asset or a collection of physical assets of interest. In one example, a method includes providing a user information goal including user information for acquisition, processing, or output of data associated with a physical asset or collection of physical assets; and evaluating existing database information to determine whether all or part of the first user information goal can be substantially completed by retrieval and processing of an information set obtainable from existing database information. If the user information goal cannot substantially be completed using the information set, then a data acquisition plan configured to acquire data needed to substantially complete first user information goal can be generated. If the user information goal can be substantially completed using the information set, then the formation set can be processed to provide an output. |
| FILED | Monday, July 03, 2023 |
| APPL NO | 18/217823 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 2101/20 (20230101) B64U 2101/30 (20230101) Image Data Processing or Generation, in General G06T 7/521 (20170101) G06T 2207/30184 (20130101) Image or Video Recognition or Understanding G06V 20/10 (20220101) G06V 20/176 (20220101) Original (OR) Class G06V 20/194 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213182 | Kozicki |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Michael Kozicki (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Kozicki (Phoenix, Arizona) |
| ABSTRACT | Systems for physical unclonable function (“PUF”) generation, PUF devices, and methods for manufacturing PUF devices. In one implementation, the system includes a plurality of PUF devices and an electronic controller. Each of the plurality of PUF devices include a first electrochemically-inactive electrode, a second electrochemically-inactive electrode, and a layer of silicon suboxide. The layer of silicon suboxide is positioned directly between the first electrochemically-inactive electrode and the second electrochemically-inactive electrode. The electronic controller is communicably coupled to the plurality of PUF devices. The electronic controller is configured to read binary values associated with the plurality of PUF devices. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431219 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/482 (20130101) H01L 23/573 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213892 | Diller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ESTAT Actuation, Inc. (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | ESTAT Actuation, Inc. (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Stuart B. Diller (Pittsburgh, Pennsylvania); Kirby A. Witte (Pittsburgh, Pennsylvania); John D. Watkins (Pittsburgh, Pennsylvania); Carmel Majidi (Pittsburgh, Pennsylvania); Brock Zekany (Pittsburgh, Pennsylvania) |
| ABSTRACT | An electroadhesive clutch using a ceramic-based dielectric layer separating opposing clutch plates, which function as electrodes. At least one of the clutch plates can be a flexible material, such as a thin film. A voltage applied across the electrodes creates an electrostatic attraction between the electrodes. The ceramic-based dielectric layer can be applied to one or both electrodes or, alternatively, placed between opposing electrodes. The ceramic-based dielectric reduces the voltage required to adhere adjacent plates, while also improving the force of adhesion. A rotary electroadhesive clutch using the ceramic-based dielectric provides improved force of adhesion and can be used to control the amount of torque transferred from an input to an output. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 18/288960 |
| CURRENT CPC | Couplings for Transmitting Rotation; Clutches; Brakes F16D 28/00 (20130101) Electric Machines Not Otherwise Provided for H02N 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240214408 | Crimmins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Braden L. Crimmins (Ann Arbor, Michigan); John Alexander Halderman (Ann Arbor, Michigan); Bradley Sturt (Urbana, Illinois) |
| ABSTRACT | A transposition error may occur in a voting machine when the voting machine switches candidates so that votes are counted for a different candidates than a voter intended. Such transposition errors may occur due to either intentional manipulation (e.g., a bad actor hacking the voting system, etc.), or unintentional human error (e.g., an unintentional human error in computer programming, etc.). In some embodiments, a “minimum test deck” is created that includes the minimum number of filled out ballots that will effectively test a voting machine to ensure that no transposition error occurred. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/394391 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 2230/00 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 13/00 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1433 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240214803 | Dandekar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Kapil R. Dandekar (Philadelphia, Pennsylvania); James J. Chacko (Huntingdon Valley, Pennsylvania); Kyle Joseph Juretus (Quakertown, Pennsylvania); Marko Jacovic (Philadelphia, Pennsylvania); Cem Sahin (Peoria, Arizona); Nagarajan Kandasamy (Philadelphia, Pennsylvania); Ioannis Savidis (Wallingford, Pennsylvania) |
| ABSTRACT | A key-based interleaver for enhancement the security of wireless communication includes a physical layer communication channel key to provide security even when the software encryption key is compromised. A method of creating a secure communication link using a physical layer interleaving system includes implementing a key policy implementation that utilizes temporal dependency and interleaving bits using a flexible inter and intra-block data interleaver. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/146145 |
| CURRENT CPC | Wireless Communication Networks H04W 12/041 (20210101) H04W 12/0431 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240215142 | Vaddi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Ravi Sankar Vaddi (Seattle, Washington); Igor V. Novosselov (Seattle, Washington); Alexander V. Mamishev (Seattle, Washington) |
| ABSTRACT | Dielectric barrier discharge plasma actuators are described. In one embodiment, a fluid flow actuator includes: a dielectric sheet; and a first electrode of a dielectric barrier discharge-direct current augmented (DBD-DCA) actuator disposed on a first face of the dielectric sheet. The first electrode is exposed to a surrounding fluid. The fluid actuator also includes a second electrode of the DBD-DCA actuator disposed on a second face of the dielectric sheet. The second face of the dielectric sheet is opposite from the first face of the dielectric sheet. The first electrode and the second electrode are configured for receiving an alternating current (AC) voltage configured to locally ionize the fluid and to generate ions. A third electrode located downstream from the first electrode and the second electrode. The third electrode is configured for receiving a direct current (DC) voltage configured to accelerate the ions. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 18/553839 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 23/005 (20130101) Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/12 (20130101) F15D 1/0075 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/2439 (20210501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240206816 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Johnson (Cincinnati, Ohio); Gregory O. Voss (Apple Valley, Minnesota); Colin G. Kenow (Saint Paul, Minnesota) |
| ABSTRACT | An apparatus having a longitudinal axis and an upper surface for supporting an individual at least partially positioned on a bed or other support structure, such as, for example, a bed within a magnetic resonance imaging (MRI) machine, is disclosed. The individual can have hips, legs and an upper back. The apparatus comprises a bladder that is configured to be positioned beneath the hips of the individual. The bladder has a first end and an opposed second end that is spaced from the first end along the longitudinal axis. The bladder is configured to expand upon receiving air from an air supply in order to elevate the hips of the individual relative to the upper back of the individual. A valve is in fluid communication with the bladder. The valve is configured to selectively allow air from the air supply into the bladder. The apparatus can be nonferrous. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 18/288482 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/702 (20130101) Original (OR) Class A61B 5/704 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207188 | Ge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); U.S. Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); U.S. Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Tianjia Jessie Ge (Sunnyvale, California); Simon Conti (Stanford, California); Joseph C. Liao (Redwood City, California); Kunj Raju Sheth (San Francisco, California); Shan X. Wang (Portola Valley, California) |
| ABSTRACT | A medical device for retrieval of kidney stone fragments from a urinary tract is provided. The medical device has a plurality of magnets arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. A removable inner stylet is situated within the flexible sheath allowing for modifiable flexibility of the wire. The medical device is dimensioned to be introduced into the urinary tract and standard endoscopic devices. The medical device is further dimensioned to allow for the wire with magnetically attached stone fragments to be retrieved from the urinary tract. The magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which have bound themselves to kidney stone fragments. |
| FILED | Wednesday, December 27, 2023 |
| APPL NO | 18/397947 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/221 (20130101) A61B 2017/0034 (20130101) A61B 2017/00876 (20130101) A61B 2017/22082 (20130101) A61B 2034/731 (20160201) Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) Original (OR) Class A61K 9/0034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207216 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Henry C. Lin (Albuquerque, New Mexico); Sudha B. Singh (Albuquerque, New Mexico); Cristina N. Coffman (Albuquerque, New Mexico) |
| ABSTRACT | A method of treating a subject having, or at risk of having, leaky gut caused by sulfate reducing bacteria generally includes administering to the subject an amount of a Snail inhibitor or an inhibitor of sulfate reducing bacteria effective to reduce ameliorate at least one symptom or clinical sign of leaky gut caused by sulfate reducing bacteria. A method of inhibiting deterioration of cellular junctions in cells contacted with sulfate reducing bacteria generally includes contacting the cells with an amount of Snail inhibitor or an inhibitor of sulfate reducing bacteria effective to reduce the extent to which the sulfate reducing bacteria deteriorate cellular junctions compared to untreated cells. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/29 (20130101) Original (OR) Class A61K 33/06 (20130101) A61K 33/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207253 | Sklar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico); THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larry A. Sklar (Albuquerque, New Mexico); Stella Jubay (Albuquerque, New Mexico); Clemencia Panilla (Cardiff, California); Marcello Giulianotti (Vero Beach, Florida); Richard Allen Houghten (Port St. Lucie, Florida); Samuel Lee (Washington, District of Columbia) |
| ABSTRACT | The present invention is directed to compounds which have been identified, as inhibitors of the expression of CDR1 (Cdr1p) and/or CDR2 (Cdr2p), both ABC-type plasma, membrane transporters, which are major contributor to antifungal therapy resistance. These compounds may be used in the treatment of fungal infections, especially Candida infections, either alone or in combination with azole antifungal agents such as fluconazole, itraconazole, miconazole, clotrimazole and the like. Often the inhibitor compounds described herein are useful for reversing the antifungal therapy resistance exhibited by the overexpression of CDR1 and/or CDR2 in strains of fungi, especially including Candida spp. Combination therapy and compositions for treating fungal infections, especially including azole resistant fungal infections represent important embodiments of the present invention. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 18/283035 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/13 (20130101) A61K 31/44 (20130101) A61K 31/137 (20130101) A61K 31/155 (20130101) A61K 31/381 (20130101) A61K 31/495 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/4015 (20130101) A61K 31/4196 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207361 | Dowling et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter C. Dowling (Sea Girt, New Jersey); Wei Lu (Sea Girt, New Jersey) |
| ABSTRACT | Described herein are dosing regimens and methods of treating multiple sclerosis with an effective amount of an erythropoietin (EPO)-derived peptide to provide sustained therapeutic effects after withdrawal of the EPO-derived peptide. The dosing regimens and methods include a treatment cycle followed by a rest phase, wherein the EPO-derived peptide is not administered during the rest phase. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 18/555169 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1816 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240207491 | Boire et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy C. Boire (Nashville, Tennessee); Hak-Joon Sung (Nashville, Tennessee); Colleen Brophy (Nashville, Tennessee) |
| ABSTRACT | The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photo crosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/380135 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/07 (20130101) A61F 2/90 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) Original (OR) Class A61L 31/16 (20130101) A61L 31/041 (20130101) A61L 2400/16 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240209775 | O'Connor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ethan Patrick O'Connor (Hamilton, Ohio); Gert Johannes van der Merwe (Lebanon, Ohio); Alexander Thomas Hills (Cincinnati, Ohio) |
| ABSTRACT | A hybrid electric gas turbine engine is provided. The hybrid electric gas turbine engine includes: a turbomachine having a compressor section and a turbine section arranged in serial flow order, the compressor section and turbine section together defining a core air flowpath, the turbomachine defining a core air flowpath exhaust; and an electric machine assembly having an electric machine disposed aft of the core air flowpath exhaust and mechanically connected to the turbine section. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/085728 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 6/00 (20130101) Original (OR) Class F02C 7/36 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210246 | RUBIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Noah A. RUBIN (Cambridge, Massachusetts); Paul CHEVALIER (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | An attachment for an intensity-only sensor in an imaging device includes a polarization-sensitive diffraction grating. The polarization-sensitive diffraction grating is configured to receive incident light from a scene, and to modify the incident light to simultaneously produce a plurality of non-overlapping images of the scene. each of a different diffraction order, on the intensity-only sensor to facilitate full-Stokes imaging polarimetry. The attachment includes a first adjustment mechanism configured to control at least one of: vignetting of the plurality of non-overlapping images on the intensity-only sensor, or an object distance of the imaging device. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 18/291204 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 4/04 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/1842 (20130101) G02B 26/0808 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210257 | Pilant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sporian Microsystems, Inc. (Lafayette, Colorado) |
| ASSIGNEE(S) | Sporian Microsystems, Inc. (Lafayette, Colorado) |
| INVENTOR(S) | Evan Pilant (Longmont, Colorado); Dale Schoonover (Louisville, Colorado); Jakob Oreskovich (Boulder, Colorado); Brittany McGrogan (Denver, Colorado); William VanHoose (Aurora, Colorado) |
| ABSTRACT | A method of shielding a capacitive pressure transducer by positioning an insulated shield spacer between the capacitor electrodes, covering the two electrodes with an electrically conductive shield box, applying a sensor voltage from a first voltage source across the two electrodes, and applying a shield voltage from a second voltage source to the insulated shield spacer and to the shield box. |
| FILED | Friday, February 09, 2024 |
| APPL NO | 18/437970 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213649 | Ahmed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Razi U. Ahmed (Pasadena, California); Vladimir S. IItchenko (La Canada, California); Ninoslav Majurec (Pasadena, California); Dmitry V. Strekalov (Arcadia, California); Andrey B. Matsko (Arcadia, California) |
| ABSTRACT | A device useful as a receiver including a waveguide interface to an antenna guiding a radio frequency (RF) signal to an RF waveguide cavity coupling the RF signal to a crystal resonator. The crystal resonator comprises a nonlinear material generating an optical output in response to a nonlinear interaction between the RF signal and an optical pump in the resonator. An optical port coupled to the crystal resonator for outputting the optical output from which the RF signal received on the antenna can be determined. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/539877 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/1225 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/213 (20130101) H01P 7/105 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240214904 | Mody et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | A10 SYSTEMS INC DBA AIRANACULUS (LOWELL, Massachusetts) |
| ASSIGNEE(S) | A10 SYSTEMS INC DBA AIRANACULUS (LOWELL, Massachusetts) |
| INVENTOR(S) | Apurva N. Mody (Chelmsford, Massachusetts); Bryan Crompton (Lowell, Massachusetts); Junaid Islam (San Jose, California); David Simpson (Springfield, Virginia); Dap Minh Tran (Lowell, Massachusetts) |
| ABSTRACT | One or more aspects of the present disclosure are directed to network optimization solutions provided as software agents (applications) executed on network nodes in a heterogenous multi-vendor environment to provide cross-layer network optimization and ensure availability of network resources to meet associated Quality of Experience (QoE) and Quality of Service (QoS). In one aspect, a network slicing engine is configured to receive at least one request from at least one network endpoint for access to the heterogeneous multi-vendor network for data transmission; receive information on state of operation of a plurality of communication links between the plurality of nodes; determine a set of data transmission routes for the request; assign a network slice for serving the request; determine, from the set of data transmission routes, an end-to-end route for the network slice; and send network traffic associated with the request using the network slice and over the end-to-end route. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/383680 |
| CURRENT CPC | Wireless Communication Networks H04W 16/02 (20130101) H04W 40/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240209235 | Glass et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Setex Technologies, Inc. (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Setex Technologies, Inc. (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Paul Samuel Glass (Pittsburgh, Pennsylvania); Aimee L. DeLuca (Pittsburgh, Pennsylvania); Burak Aksak (Pittsburgh, Pennsylvania) |
| ABSTRACT | An adhesive material providing permeation-resistant characteristics, wherein the material comprises a surface having a plurality of microstructures interspersed with at least one ridge. The ridge is adapted to make continuous contact with a mating surface. In one embodiment, the ridge is linear. In an alternative embodiment, the ridge has a square pattern forming a mesh on the surface. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/909798 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/00 (20130101) Original (OR) Class C09J 2301/31 (20200801) C09J 2301/206 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212143 | BUCKLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Kjell JOHNSON (Ann Arbor, Michigan); Xiaonan MA (South Hamilton, Massachusetts); Keith A. MOULTON (Amesbury, Massachusetts); David S. PAIK (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data. |
| FILED | Wednesday, January 17, 2024 |
| APPL NO | 18/415137 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) G06F 18/211 (20230101) G06F 18/2148 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 5/73 (20240101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10048 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10101 (20130101) G06T 2207/10104 (20130101) G06T 2207/10108 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240212542 | MOULTON, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | JRM Enterprises, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Russ MOULTON, Jr. (Orlando, Florida); Steve BUTRIMAS (Orlando, Florida); Christopher FINK (Orlando, Florida); Dan BYBEE (Orlando, Florida); Isaac EHLERS (Orlando, Florida); William HILTON (Orlando, Florida) |
| ABSTRACT | A dynamic infrared (IR) scene generation system comprising a thin-film screen configured to react to contact by an IR laser; a laser scanning system configured to contact the thin-film screen with laser beam, the laser scanning system comprising a laser scanner, one or more modulators, and an IR laser source; and an image processing system operably connected to a controller configured to control the laser scanning system based on data from the image processing system, wherein the laser scanning system can be configured to contact the thin-film screen with the IR laser based on an IR scene input. |
| FILED | Wednesday, August 09, 2023 |
| APPL NO | 18/447106 |
| CURRENT CPC | Weapon Sights; Aiming F41G 3/165 (20130101) Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240213892 | Diller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ESTAT Actuation, Inc. (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | ESTAT Actuation, Inc. (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Stuart B. Diller (Pittsburgh, Pennsylvania); Kirby A. Witte (Pittsburgh, Pennsylvania); John D. Watkins (Pittsburgh, Pennsylvania); Carmel Majidi (Pittsburgh, Pennsylvania); Brock Zekany (Pittsburgh, Pennsylvania) |
| ABSTRACT | An electroadhesive clutch using a ceramic-based dielectric layer separating opposing clutch plates, which function as electrodes. At least one of the clutch plates can be a flexible material, such as a thin film. A voltage applied across the electrodes creates an electrostatic attraction between the electrodes. The ceramic-based dielectric layer can be applied to one or both electrodes or, alternatively, placed between opposing electrodes. The ceramic-based dielectric reduces the voltage required to adhere adjacent plates, while also improving the force of adhesion. A rotary electroadhesive clutch using the ceramic-based dielectric provides improved force of adhesion and can be used to control the amount of torque transferred from an input to an output. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 18/288960 |
| CURRENT CPC | Couplings for Transmitting Rotation; Clutches; Brakes F16D 28/00 (20130101) Electric Machines Not Otherwise Provided for H02N 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240214904 | Mody et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | A10 SYSTEMS INC DBA AIRANACULUS (LOWELL, Massachusetts) |
| ASSIGNEE(S) | A10 SYSTEMS INC DBA AIRANACULUS (LOWELL, Massachusetts) |
| INVENTOR(S) | Apurva N. Mody (Chelmsford, Massachusetts); Bryan Crompton (Lowell, Massachusetts); Junaid Islam (San Jose, California); David Simpson (Springfield, Virginia); Dap Minh Tran (Lowell, Massachusetts) |
| ABSTRACT | One or more aspects of the present disclosure are directed to network optimization solutions provided as software agents (applications) executed on network nodes in a heterogenous multi-vendor environment to provide cross-layer network optimization and ensure availability of network resources to meet associated Quality of Experience (QoE) and Quality of Service (QoS). In one aspect, a network slicing engine is configured to receive at least one request from at least one network endpoint for access to the heterogeneous multi-vendor network for data transmission; receive information on state of operation of a plurality of communication links between the plurality of nodes; determine a set of data transmission routes for the request; assign a network slice for serving the request; determine, from the set of data transmission routes, an end-to-end route for the network slice; and send network traffic associated with the request using the network slice and over the end-to-end route. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/383680 |
| CURRENT CPC | Wireless Communication Networks H04W 16/02 (20130101) H04W 40/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240207219 | Shell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts); The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scarlet S. Shell (Shrewsbury, Massachusetts); Pamela Weathers (Stow, Massachusetts); Joshua J. Kellogg (University Park, Pennsylvania) |
| ABSTRACT | Artemisia annua and A. afra dichloromethane extracts contain bactericidal activity against Mycobacterium tuberculosis (Mtb) strain mc26230 under natural infection stress conditions: carbon source metabolism (glycerol, dextrose, and cholesterol) and hypoxia. Significant bactericidal activity against Mtb was observed regardless of carbon source. Extracts from A. afra showed the highest bactericidal activity against Mtb for tested carbon sources, and A. annua bactericidal activity was greatest against Mtb in minimal media with glycerol. A. annua and A. afra. extracts were bactericidal against Mtb under hypoxic conditions. Growth was halted and viability diminished several logs-fold under hypoxic conditions in the presence of each extract. Transcriptomic analysis revealed that A. afra exerts different effects on Mtb than artemisinin, indicative of phytochemicals in A. afra with unique modes of action. Biochemometric analysis of A. afra resulted in isolation of a methoxylated flavone (compound 1), with considerable activity against Mtb strain mc26230. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392419 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class A61K 36/282 (20130101) A61K 45/06 (20130101) A61K 49/0008 (20130101) A61K 2236/15 (20130101) A61K 2236/39 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240210426 | KIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); NATIONAL AGRICULTURAL PRODUCTS QUALITY MANAGEMENT SERVICE (GYEONGSANGBUK-DO, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MOON S. KIM (ASHTON, Maryland); JIANWEI QIN (ELLICOTT CITY, Maryland); JO ANN S. VAN KESSEL (ELLICOTT CITY, Maryland); JEEHWA HONG (GIMCHEON-SI, South Korea); HYUNJEONG CHO (SEOUL, South Korea) |
| ABSTRACT | The portable multimodal optical sensing system is an integrated system/tool for intelligent food safety inspection. The system includes a pair of lasers and corresponding spectrometers working at different wavelengths to enable an operator to obtain high-quality Raman scattering data from both low- and high-fluorescence food samples. By utilizing machine vision and motion control techniques, the system can conduct fully automated spectral data acquisition for randomly scattered samples that are deposited in Petri dishes or placed in customized well plates. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/087391 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/27 (20130101) G01N 21/65 (20130101) G01N 35/00029 (20130101) Original (OR) Class G01N 2201/0484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20240211134 | Kalamatianos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | John Kalamatianos (Arlington, Massachusetts); Karthik Ramu Sangaiah (Seattle, Washington); Anthony Thomas Gutierrez (Seattle, Washington) |
| ABSTRACT | A memory controller includes an arbiter, a vector arithmetic logic unit (VALU), a read buffer and a write buffer both coupled to the VALU, and an atomic memory operation scheduler. The VALU performs scattered atomic memory operations on arrays of data elements responsive to selected memory access commands. The atomic memory operation scheduler is for scheduling atomic memory operations at the VALU; identifying a plurality of scattered atomic memory operations with commutative and associative properties, the plurality of scattered atomic memory operations on at least one element of an array of data elements associated with an address; and commanding the VALU to perform the plurality of scattered atomic memory operations. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/087964 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/061 (20130101) Original (OR) Class G06F 3/0656 (20130101) G06F 3/0659 (20130101) G06F 3/0673 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240211407 | Kalamatianos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | John Kalamatianos (Arlington, Massachusetts); Jagadish B. Kotra (Austin, Texas); Asmita Pal (Madison, Wisconsin) |
| ABSTRACT | A memory request issue counter (MRIC) is maintained that is incremented for every memory access a central processing unit core makes. A region reuse distance table is also maintained that includes multiple entries each of which stores the region reuse distance for a corresponding region. When a memory access request for a physical address is received, a reuse distance for the physical address is calculated. This reuse distance is the difference between the current MRIC value and a previous MRIC value for the physical address. The previous MRIC value for the physical address is the MRIC value the MRIC had when a memory access request for the physical address was last received. A region reuse distance for a region that includes the physical address is generated based on the reuse distance for the physical address and used to manage the cache. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/146883 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0888 (20130101) Original (OR) Class G06F 2212/1016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Geospatial Intelligence Agency (NGA)
| US 20240212203 | Warnaar |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Applied Research Associates, Inc. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dirk B. Warnaar (Raleigh, North Carolina) |
| ABSTRACT | Systems and techniques for determining a list of geographic location candidates from an image of an environment are described. Open source data indicative of the earth's surface may be obtained and combined into grids to create region data to gain a representation of the earth's surface within each grid cell. An image of an environment may be obtained from an unknown camera. Image characteristics may be compared to the region data to determine error between the image characteristics and projections of the region data. A list of lowest error geographic location candidates may be determined and provided to the user. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/432724 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/04 (20130101) Image Data Processing or Generation, in General G06T 7/73 (20170101) Original (OR) Class G06T 7/80 (20170101) G06T 2207/30244 (20130101) Pictorial Communication, e.g Television H04N 13/111 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20240215142 | Vaddi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Ravi Sankar Vaddi (Seattle, Washington); Igor V. Novosselov (Seattle, Washington); Alexander V. Mamishev (Seattle, Washington) |
| ABSTRACT | Dielectric barrier discharge plasma actuators are described. In one embodiment, a fluid flow actuator includes: a dielectric sheet; and a first electrode of a dielectric barrier discharge-direct current augmented (DBD-DCA) actuator disposed on a first face of the dielectric sheet. The first electrode is exposed to a surrounding fluid. The fluid actuator also includes a second electrode of the DBD-DCA actuator disposed on a second face of the dielectric sheet. The second face of the dielectric sheet is opposite from the first face of the dielectric sheet. The first electrode and the second electrode are configured for receiving an alternating current (AC) voltage configured to locally ionize the fluid and to generate ions. A third electrode located downstream from the first electrode and the second electrode. The third electrode is configured for receiving a direct current (DC) voltage configured to accelerate the ions. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 18/553839 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 23/005 (20130101) Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/12 (20130101) F15D 1/0075 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/2439 (20210501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240211869 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | The present disclosure relates to a system and method for improving scan rates of an item in a distribution network. The system may include an item scan database storing item scan datasets containing barcodes, item datasets and optical character recognition (OCR) labels datasets and a processor in data communication with the item scan database. The processor may detect an item barcode with an item orientation so as to output correct orientation information of the item. The processor may also extract available barcode information from the detected item barcode based on the correct orientation information of the item. The processor may further reconstruct a correct barcode from the extracted available barcode information and one or more of the item scan datasets. |
| FILED | Monday, March 11, 2024 |
| APPL NO | 18/601324 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/1456 (20130101) Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) G06Q 10/0838 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/40 (20220101) G06V 30/10 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240210164 | Garg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| INVENTOR(S) | Piyush Garg (Albuquerque, New Mexico); Mahmoud Reda Taha (Albuquerque, New Mexico); Fernando Moreu (Albuquerque, New Mexico) |
| ABSTRACT | A system for measuring the dynamic displacement of a structure reference free comprising: a laser Doppler vibrometer (LDV); an unmanned aerial system (UAS), said LDV mounted on said UAS; and a processor in communication with said LDV adapted to compensate error in the LDV output due to the UAS movement. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/544117 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02045 (20130101) G01B 11/14 (20130101) Original (OR) Class Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, June 27, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240627.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page